Sample records for 16-cell stage transition

  1. From oocyte to 16-cell stage: cytoplasmic and cortical reorganizations that pattern the ascidian embryo. (United States)

    Sardet, Christian; Paix, Alexandre; Prodon, François; Dru, Philippe; Chenevert, Janet


    The dorsoventral and anteroposterior axes of the ascidian embryo are defined before first cleavage by means of a series of reorganizations that reposition cytoplasmic and cortical domains established during oogenesis. These domains situated in the periphery of the oocyte contain developmental determinants and a population of maternal postplasmic/PEM RNAs. One of these RNAs (macho-1) is a determinant for the muscle cells of the tadpole embryo. Oocytes acquire a primary animal-vegetal (a-v) axis during meiotic maturation, when a subcortical mitochondria-rich domain (myoplasm) and a domain rich in cortical endoplasmic reticulum (cER) and maternal postplasmic/PEM RNAs (cER-mRNA domain) become polarized and asymmetrically enriched in the vegetal hemisphere. Fertilization at metaphase of meiosis I initiates a series of dramatic cytoplasmic and cortical reorganizations of the zygote, which occur in two major phases. The first major phase depends on sperm entry which triggers a calcium wave leading in turn to an actomyosin-driven contraction wave. The contraction concentrates the cER-mRNA domain and myoplasm in and around a vegetal/contraction pole. The precise localization of the vegetal/contraction pole depends on both the a-v axis and the location of sperm entry and prefigures the future site of gastrulation and dorsal side of the embryo. The second major phase of reorganization occurs between meiosis completion and first cleavage. Sperm aster microtubules and then cortical microfilaments cause the cER-mRNA domain and myoplasm to reposition toward the posterior of the zygote. The location of the posterior pole depends on the localization of the sperm centrosome/aster attained during the first major phase of reorganization. Both cER-mRNA and myoplasm domains localized in the posterior region are partitioned equally between the first two blastomeres and then asymmetrically over the next two cleavages. At the eight-cell stage the cER-mRNA domain compacts and gives rise to

  2. Determinants of forward stage transitions : a Delphi study

    NARCIS (Netherlands)

    De Vet, E; Brug, J; De Nooijer, J; Dijkstra, A; De Vries, NK


    Insight into stage transition determinants is necessary to develop and evaluate stage-tailored health-promoting interventions. A three-round Delphi study among stages of change researchers was conducted to make an inventory of opinions and examine agreement on determinants of forward transitions bet

  3. Stage-specific psychological determinants of stage transition

    NARCIS (Netherlands)

    Dijkstra, A.; Tromp, D; Conijn, B


    Objectives. The stages of change construct refers to the different psychological states people move through when they change their behaviour. However, the prediction that people in different stages of change need different sorts of interventions to stimulate the change process has scarcely been test

  4. Asymmetry and basic pathways in sleep-stage transitions (United States)

    Lo, Chung-Chuan; Bartsch, Ronny P.; Ivanov, Plamen Ch.


    We study dynamical aspects of sleep micro-architecture. We find that sleep dynamics exhibits a high degree of asymmetry, and that the entire class of sleep-stage transition pathways underlying the complexity of sleep dynamics throughout the night can be characterized by two independent asymmetric transition paths. These basic pathways remain stable under sleep disorders, even though the degree of asymmetry is significantly reduced. Our findings demonstrate an intriguing temporal organization in sleep micro-architecture at short time scales that is typical for physical systems exhibiting self-organized criticality (SOC), and indicates nonequilibrium critical dynamics in brain activity during sleep.

  5. Obstructive sleep apnea alters sleep stage transition dynamics.

    Directory of Open Access Journals (Sweden)

    Matt T Bianchi

    Full Text Available INTRODUCTION: Enhanced characterization of sleep architecture, compared with routine polysomnographic metrics such as stage percentages and sleep efficiency, may improve the predictive phenotyping of fragmented sleep. One approach involves using stage transition analysis to characterize sleep continuity. METHODS AND PRINCIPAL FINDINGS: We analyzed hypnograms from Sleep Heart Health Study (SHHS participants using the following stage designations: wake after sleep onset (WASO, non-rapid eye movement (NREM sleep, and REM sleep. We show that individual patient hypnograms contain insufficient number of bouts to adequately describe the transition kinetics, necessitating pooling of data. We compared a control group of individuals free of medications, obstructive sleep apnea (OSA, medical co-morbidities, or sleepiness (n = 374 with mild (n = 496 or severe OSA (n = 338. WASO, REM sleep, and NREM sleep bout durations exhibited multi-exponential temporal dynamics. The presence of OSA accelerated the "decay" rate of NREM and REM sleep bouts, resulting in instability manifesting as shorter bouts and increased number of stage transitions. For WASO bouts, previously attributed to a power law process, a multi-exponential decay described the data well. Simulations demonstrated that a multi-exponential process can mimic a power law distribution. CONCLUSION AND SIGNIFICANCE: OSA alters sleep architecture dynamics by decreasing the temporal stability of NREM and REM sleep bouts. Multi-exponential fitting is superior to routine mono-exponential fitting, and may thus provide improved predictive metrics of sleep continuity. However, because a single night of sleep contains insufficient transitions to characterize these dynamics, extended monitoring of sleep, probably at home, would be necessary for individualized clinical application.

  6. Following analytically stages of transition in Couette flow (United States)

    Karp, Michael; Cohen, Jacob


    A possible explanation for transition in Couette flow is the mechanism of transient growth (TG). Accordingly, a small disturbance can achieve a significant non-modal TG and trigger nonlinear mechanisms before its eventual decay owing to viscosity. The linear optimal disturbance achieving the maximal growth consists of a pair of streamwise independent counter-rotating vortices (CVPs) which create spanwise-varying streamwise streaks. These may become unstable with respect to infinitesimal disturbances. It is shown that four decaying normal modes, obtained analytically, are sufficient to follow the linear TG mechanism. A secondary linear stability analysis of the modified base-flow (Couette flow with streaks) is conducted using Floquet theory for the spanwise periodic base-flow. The predictions of the stability analysis are compared with direct numerical simulations using the ``Channelflow'' code. It is shown analytically that the inclusion of nonlinear interactions between the base-flow and the CVPs is required in order to predict instability. Furthermore, it is demonstrated that the generation of a `strong' inflectional point is more important than obtaining maximal growth. The minimal number of modes enables us to follow analytically several key stages of the transition process.

  7. Staging transition: the Oresteia in post-apartheid South Africa

    NARCIS (Netherlands)

    van Weyenberg, A.; Bal, M.; Hernández-Navarro, M.Á.


    Aeschylus' Oresteia dramatizes the meaning and political deployment of justice, concluding with the transformation of justice as vengeance into the legal justice of Athens's new democracy. In this essay, I examine two dramatic texts that draw on the Oresteia within another context of transitional ju

  8. Modeling river dune development and dune transition to upper stage plane bed


    Naqshband, S.; Duin, van, W.E.; Ribberink, J.S.; Hulscher, S.J.M.H.


    Large asymmetric bedforms known as dunes commonly dominate the bed of sand rivers. Due to the turbulence generation over their stoss and lee sides, dunes are of central importance in predicting hydraulic roughness and water levels. During floods in steep alluvial rivers, dunes are observed to grow rapidly as flow strength increases, undergoing an unstable transition regime, after which they are washed out in what is called upper stage plane bed. This transition of dunes to upper stage plane b...

  9. Emotional and Motivational Engagement at School Transition: A Qualitative Stage-Environment Fit Study (United States)

    Symonds, Jennifer; Hargreaves, Linda


    Adolescents typically like school less after making age-graded school transitions. Stage-environment fit theory (Eccles & Midgley, 1989) attributes this to a mismatch between developmental needs and new school environments. Our in vivo study provides a basis for future quantitative designs by uncovering the most prevalent stage-environment…

  10. The Transtheoretical model for fruit, vegetable and fish consumption: associations between intakes, stages of change and stage transition determinants

    Directory of Open Access Journals (Sweden)

    de Vries Nanne K


    Full Text Available Abstract Background Cardiovascular diseases are caused by multiple behavioral factors, including different dietary factors. We examined to what extent fruit, vegetable and fish consumption are related, and whether behavioral determinants vary across these dietary behaviors from a Transtheoretical model perspective. Methods Data were collected among 1142 participants (T0; response rate 46% selected from an Internet panel, who were followed-up one-week later (T1; N = 1055, response rate 92%. Mean age was 35.4 (SD = 11.9 years, 35% was male, and most respondents were of Dutch origin (90%. Of the respondents, 13%, 44% and 43% had a low, medium or high level of education, respectively. Electronic questionnaires assessed fruit, vegetable and fish intake (food frequency questionnaires, stages of change, decisional balance and self-efficacy, for each of these three behaviors. Results Stages of change and (changes in fruit, vegetable and fish intake were only weakly associated; decisional balance and self-efficacy were more strongly associated. Some presumed predictors of stage transitions were similar for fruit, vegetable, and fish intake, i.e., strong pros predicted progress out of precontemplators and low self-efficacy predicted relapse from action/maintenance for all behaviors. However, progress out of contemplation and out of preparation showed different patterns for fruit, vegetable and fish intake. Conclusion The weak associations between intakes and potential determinants for fruit, vegetable, and fish consumption do not warrant an integrated dietary change approach targeting the same determinants for each behavior.

  11. Sleep-stage transitions during polysomnographic recordings as diagnostic features of type 1 narcolepsy

    DEFF Research Database (Denmark)

    Christensen, Julie Anja Engelhard; Carrillo, Oscar; Leary, Eileen B.;


    Objective: Type 1 narcolepsy/hypocretin deficiency is characterized by excessive daytime sleepiness, sleep fragmentation, and cataplexy. Short rapid eye movement (REM) latency (≤15 min) during nocturnal polysomnography (PSG) or during naps of the multiple sleep latency test (MSLT) defines a sleep......-onset REM sleep period (SOREMP), a diagnostic hallmark. We hypothesized that abnormal sleep transitions other than SOREMPs can be identified in type 1 narcolepsy. Methods: Sleep-stage transitions (one to 10 epochs to one to five epochs of any other stage) and bout length features (one to 10 epochs) were...... ≥2.5 min of W/N1 into REM are specifically diagnostic for narcolepsy independent of a nocturnal SOREMP....

  12. Numerical simulation of dune-flat bed transition and stage-discharge relationship with hysteresis effect (United States)

    Shimizu, Y.; Giri, S.; Yamaguchi, S.; Nelson, Jack L.


    This work presents recent advances on morphodynamic modeling of bed forms under unsteady discharge. This paper includes further development of a morphodynamic model proposed earlier by Giri and Shimizu (2006a). This model reproduces the temporal development of river dunes and accurately replicates the physical properties associated with bed form evolution. Model results appear to provide accurate predictions of bed form geometry and form drag over bed forms for arbitrary steady flows. However, accurate predictions of temporal changes of form drag are key to the prediction of stage-discharge relation during flood events. Herein, the model capability is extended to replicate the dune-flat bed transition, and in turn, the variation of form drag produced by the temporal growth or decay of bed forms under unsteady flow conditions. Some numerical experiments are performed to analyze hysteresis of the stage-discharge relationship caused by the transition between dune and flat bed regimes during rising and falling stages of varying flows. The numerical model successfully simulates dune-flat bed transition and the associated hysteresis of the stage-discharge relationship; this is in good agreement with physical observations but has been treated in the past only using empirical methods. A hypothetical relationship for a sediment parameter (the mean step length) is proposed to a first level of approximation that enables reproduction of the dune-flat bed transition. The proposed numerical model demonstrates its ability to address an important practical problem associated with bed form evolution and flow resistance in varying flows. Copyright 2009 by the American Geophysical Union.

  13. Environmental correlates of peatland carbon fluxes in a thawing landscape: do transitional thaw stages matter?

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    A. Malhotra


    Full Text Available Peatlands in discontinuous permafrost regions occur as a mosaic of wetland types, each with variable sensitivity to climate change. Permafrost thaw further increases the spatial heterogeneity in ecosystem structure and function in peatlands. Carbon (C fluxes are well characterized in end-member thaw stages such as fully intact or fully thawed permafrost but remain unconstrained for transitional stages that cover a significant area of thawing peatlands. Furthermore, changes in the environmental correlates of C fluxes, due to thaw are not well described: a requirement for modeling future changes to C storage of permafrost peatlands. We investigated C fluxes and their correlates in end-member and a number of transitional thaw stages in a sub-arctic peatland. Across peatland lumped CH4 and CO2 flux data had significant correlations with expected correlates such as water table depth, thaw depth, temperature, photosynthetically active radiation and vascular green area. Within individual thaw states, bivariate correlations as well as multiple regressions between C flux and environmental factors changed variably with increasing thaw. The variability in directions and magnitudes of correlates reflects the range of structural conditions that could be present along a thaw gradient. These structural changes correspond to changes in C flux controls, such as temperature and moisture, and their interactions. Temperature sensitivity of CH4 increased with increasing thaw in bivariate analyses, but lack of this trend in multiple regression analyses suggested cofounding effects of substrate or water limitation on the apparent temperature sensitivity. Our results emphasize the importance of incorporating transitional stages of thaw in landscape level C budgets and highlight that end-member or adjacent thaw stages do not adequately describe the variability in structure-function relationships present along a thaw gradient.

  14. 76 FR 18930 - Medicare Programs: Changes to the End-Stage Renal Disease Prospective Payment System Transition... (United States)


    ...: Changes to the End-Stage Renal Disease Prospective Payment System Transition Budget-Neutrality Adjustment... period. SUMMARY: This interim final rule with comment will revise the end-stage renal disease (ESRD...-Stage Renal Disease Prospective Payment System'', hereinafter, referred to as the CY 2011 ESRD PPS...

  15. Increased Hemodynamic Load in Early Embryonic Stages Alters Endocardial to Mesenchymal Transition (United States)

    Midgett, Madeline; López, Claudia S.; David, Larry; Maloyan, Alina; Rugonyi, Sandra


    Normal blood flow is essential for proper heart formation during embryonic development, as abnormal hemodynamic load (blood pressure and shear stress) results in cardiac defects seen in congenital heart disease. However, the progressive detrimental remodeling processes that relate altered blood flow to cardiac defects remain unclear. Endothelial–mesenchymal cell transition is one of the many complex developmental events involved in transforming the early embryonic outflow tract into the aorta, pulmonary trunk, interventricular septum, and semilunar valves. This study elucidated the effects of increased hemodynamic load on endothelial–mesenchymal transition remodeling of the outflow tract cushions in vivo. Outflow tract banding was used to increase hemodynamic load in the chicken embryo heart between Hamburger and Hamilton stages 18 and 24. Increased hemodynamic load induced increased cell density in outflow tract cushions, fewer cells along the endocardial lining, endocardium junction disruption, and altered periostin expression as measured by confocal microscopy analysis. In addition, 3D focused ion beam scanning electron microscopy analysis determined that a portion of endocardial cells adopted a migratory shape after outflow tract banding that is more irregular, elongated, and with extensive cellular projections compared to normal cells. Proteomic mass-spectrometry analysis quantified altered protein composition after banding that is consistent with a more active stage of endothelial–mesenchymal transition. Outflow tract banding enhances the endothelial–mesenchymal transition phenotype during formation of the outflow tract cushions, suggesting that endothelial–mesenchymal transition is a critical developmental process that when disturbed by altered blood flow gives rise to cardiac malformation and defects. PMID:28228731

  16. Disruption of transitional stages in 24-h blood pressure in renal transplant recipients

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    Marcelo E Katz


    Full Text Available Patients with kidney replacement exhibit disrupted circadian rhythms. Most studies measuring blood pressure use the dipper/non-dipper classification, which does not consider analysis of transitional stages between low and high blood pressure, confidence intervals nor shifts in the time of peak, while assuming subjective onsets of night and day phases. In order to better understand the nature of daily variation of blood pressure in these patients, we analyzed 24h recordings from 41 renal transplant recipients using the non-symmetrical double-logistic fitting assessment which does not assume abruptness nor symmetry in ascending and descending stages of the blood pressure profile, and a cosine best-fitting regression method (Cosinor. Compared with matched controls, double-logistic fitting showed that the times for most of transitional stages (ascending systolic and descending systolic, diastolic and mean arterial pressure had a wider distribution along the 24 h. The proportion of individuals without daily blood pressure rhythm in the transplanted group was larger only for systolic arterial pressure, and the amplitude showed no significant difference. Furthermore, the transplant recipient group had a less pronounced slope in descending systolic and ascending mean blood pressure. Cosinor analysis confirmed the phase related changes, showing a wider distribution of times of peak (acrophases. We conclude that daily disruptions in renal transplant recipients can be explained not only by absence in diurnal variation, but also in changes in waveform-related parameters of the rhythm, and that distortions in the phase of the rhythm are the most consistent finding for the patients.

  17. America's Next Great Ship: Space Launch System Core Stage Transitioning from Design to Manufacturing (United States)

    Birkenstock, Benjamin; Kauer, Roy


    The Space Launch System (SLS) Program is essential to achieving the Nation's and NASA's goal of human exploration and scientific investigation of the solar system. As a multi-element program with emphasis on safety, affordability, and sustainability, SLS is becoming America's next great ship of exploration. The SLS Core Stage includes avionics, main propulsion system, pressure vessels, thrust vector control, and structures. Boeing manufactures and assembles the SLS core stage at the Michoud Assembly Facility (MAF) in New Orleans, LA, a historical production center for Saturn V and Space Shuttle programs. As the transition from design to manufacturing progresses, the importance of a well-executed manufacturing, assembly, and operation (MA&O) plan is crucial to meeting performance objectives. Boeing employs classic techniques such as critical path analysis and facility requirements definition as well as innovative approaches such as Constraint Based Scheduling (CBS) and Cirtical Chain Project Management (CCPM) theory to provide a comprehensive suite of project management tools to manage the health of the baseline plan on both a macro (overall project) and micro level (factory areas). These tools coordinate data from multiple business systems and provide a robust network to support Material & Capacity Requirements Planning (MRP/CRP) and priorities. Coupled with these tools and a highly skilled workforce, Boeing is orchestrating the parallel buildup of five major sub assemblies throughout the factory. Boeing and NASA are transforming MAF to host state of the art processes, equipment and tooling, the most prominent of which is the Vertical Assembly Center (VAC), the largest weld tool in the world. In concert, a global supply chain is delivering a range of structural elements and component parts necessary to enable an on-time delivery of the integrated Core Stage. SLS is on plan to launch humanity into the next phase of space exploration.

  18. Stage-specific histone modification profiles reveal global transitions in the Xenopus embryonic epigenome.

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    Tobias D Schneider

    Full Text Available Vertebrate embryos are derived from a transitory pool of pluripotent cells. By the process of embryonic induction, these precursor cells are assigned to specific fates and differentiation programs. Histone post-translational modifications are thought to play a key role in the establishment and maintenance of stable gene expression patterns underlying these processes. While on gene level histone modifications are known to change during differentiation, very little is known about the quantitative fluctuations in bulk histone modifications during development. To investigate this issue we analysed histones isolated from four different developmental stages of Xenopus laevis by mass spectrometry. In toto, we quantified 59 modification states on core histones H3 and H4 from blastula to tadpole stages. During this developmental period, we observed in general an increase in the unmodified states, and a shift from histone modifications associated with transcriptional activity to transcriptionally repressive histone marks. We also compared these naturally occurring patterns with the histone modifications of murine ES cells, detecting large differences in the methylation patterns of histone H3 lysines 27 and 36 between pluripotent ES cells and pluripotent cells from Xenopus blastulae. By combining all detected modification transitions we could cluster their patterns according to their embryonic origin, defining specific histone modification profiles (HMPs for each developmental stage. To our knowledge, this data set represents the first compendium of covalent histone modifications and their quantitative flux during normogenesis in a vertebrate model organism. The HMPs indicate a stepwise maturation of the embryonic epigenome, which may be causal to the progressing restriction of cellular potency during development.

  19. Role of Detuning in the Final Stage of Subharmonic Mode Transition in Boundary Layers (United States)

    Corke, Thomas C.


    This work involves mechanisms for transition to turbulence in a Blasius boundary layer through resonant interactions between a plane Tollmien-Schlichting Wave and pairs of oblique waves with equal-but-opposite wave angles. When the frequency of the TS wave is exactly twice that of the oblique waves, we have a "tuned" subharmonic resonance. This leads to the enhanced growth of the oblique modes. Following this, other nonlinear interactions lead to the growth of other 3-D modes which are harmonically based, along with a 3-D mean flow distortion. In the final stage of this process, a gradual spectral filling occurs which we have traced to the growth of fundamental and subharmonic side-band modes. To simulate this with controlled inputs, we introduced the oblique wave pairs at the same conditions, but shifted the frequency of the plane TS mode (by as much as 12 percent) so that it was not exactly twice that of the 3-D modes. These "detuned" conditions also lead to the enhanced growth of the oblique modes, as well as discrete side-band modes which come about through sum and difference interactions. Other interactions quickly lead to a broad band of discrete modes. Of particular importance is the lowest difference frequency which produces a low frequency modulation similar to what has been seen in past experiments with natural 3-D mode input. Cross-bispectral analysis of time series allows us to trace the origin and development of the different modes. Following these leads to a scenario which we believe is more relevant to conditions of "natural" transitions, where low amplitude background disturbances either lead to the gradual detuning of exact fundamental/subharmonic resonance, or in which 3-D mode resonance is detuned from the onset. The results contrast the two conditions, and document the propensity of the 2-D/3-D mode interactions to become detuned.

  20. Comparative Glycoproteome Analysis: Dynamics of Protein Glycosylation during Metamorphic Transition from Pelagic to Benthic Life Stages in Three Invertebrates

    KAUST Repository

    Chandramouli, Kondethimmanahalli


    The life cycle of most benthic marine invertebrates has two distinct stages: the pelagic larval stage and the sessile juvenile stage. The transition between the larval stage and the juvenile stage is often abrupt and may be triggered by post-translational modification of proteins. Glycosylation, a very important post-translational modification, influences the biological activity of proteins. We used two-dimensional gel electrophoresis (2-DE) followed by glycoprotein-specific fluorescence staining and mass spectrometry with the goal of identifying glycosylation pattern changes during larval settlement and metamorphosis in barnacles, bryozoans, and polychaetes. Our results revealed substantial changes in the protein glycosylation patterns from larval to juvenile stages. Before metamorphosis, the degree of protein glycosylation was high in the barnacle Balanus (=Amphibalanus) amphitrite and the spionid polychaete Pseudopolydora vexillosa, whereas it increased after metamorphosis in the bryozoan Bugula neritina. We identified 19 abundant and differentially glycosylated proteins in these three species. Among the proteins, cellular stress- and metabolism-related proteins exhibited distinct glycosylation in B. amphitrite and B. neritina, whereas fatty acid metabolism-related proteins were abundantly glycosylated in P. vexillosa. Furthermore, the protein and gene expression analysis of some selected glycoproteins revealed that the degree of protein glycosylation did not always complement with transcriptional and translational changes associated with the larval-juvenile transition. The current study provides preliminary information on protein glycosylation in marine invertebrates that will serve as a solid basis for future comprehensive analysis of glycobiology during larval settlement and metamorphosis. © 2011 American Chemical Society.

  1. Evidence of Auger-like transitions in the repair stage of ultraviolet mutated DNA (United States)

    Bohr, Henrik G.; Malik, F. Bary


    It is proposed that an Auger-like transition is involved in repairing damaged di-thyamine when coming in contact with optically exposed cofactor (FADH-)*. The calculated rate is in agreement with the observed rate of 10 s.

  2. Evidence of Auger-like transitions in the repair stage of ultraviolet mutated DNA

    Energy Technology Data Exchange (ETDEWEB)

    Bohr, Henrik G. [Quantum Protein Contre, Department of Physics, Technical University of Denmark, DK-2800 Kgs. Lyngby (Denmark)]. E-mail:; Malik, F. Bary [Physics Department, Southern Illinois University, Carbondale, IL 62901 (United States); Physics Department, Washington University, St. Louis, MS (United States)


    It is proposed that an Auger-like transition is involved in repairing damaged di-thyamine when coming in contact with optically exposed cofactor (FADH{sup -}){sup *}. The calculated rate is in agreement with the observed rate of 10{sup -10} s.

  3. Practical Considerations Concerning the Interleaved Transition Mode Single-stage Ballast

    DEFF Research Database (Denmark)

    Teodorescu, Remus; Kjær, Søren Bækhøj; Munk-Nielsen, Stig;


    The aim of this paper is to present a novel single-stage interleaved ballast focusing on practical design aspects like: key current expression, overall losses, harmonic analysis of the differential-mode EMI current and preheating ballast function. A new preheating method is also presented. A PSPICE...... model is used to perform the analysis....

  4. Transcriptomic analysis reveals metabolic switches and surface remodeling as key processes for stage transition in Trypanosoma cruzi (United States)

    Greif, Gonzalo; Rodriguez, Matias; Alvarez-Valin, Fernando


    American trypanosomiasis is a chronic and endemic disease which affects millions of people. Trypanosoma cruzi, its causative agent, has a life cycle that involves complex morphological and functional transitions, as well as a variety of environmental conditions. This requires a tight regulation of gene expression, which is achieved mainly by post-transcriptional regulation. In this work we conducted an RNAseq analysis of the three major life cycle stages of T. cruzi: amastigotes, epimastigotes and trypomastigotes. This analysis allowed us to delineate specific transcriptomic profiling for each stage, and also to identify those biological processes of major relevance in each state. Stage specific expression profiling evidenced the plasticity of T. cruzi to adapt quickly to different conditions, with particular focus on membrane remodeling and metabolic shifts along the life cycle. Epimastigotes, which replicate in the gut of insect vectors, showed higher expression of genes related to energy metabolism, mainly Krebs cycle, respiratory chain and oxidative phosphorylation related genes, and anabolism related genes associated to nucleotide and steroid biosynthesis; also, a general down-regulation of surface glycoprotein coding genes was seen at this stage. Trypomastigotes, living extracellularly in the bloodstream of mammals, express a plethora of surface proteins and signaling genes involved in invasion and evasion of immune response. Amastigotes mostly express membrane transporters and genes involved in regulation of cell cycle, and also express a specific subset of surface glycoprotein coding genes. In addition, these results allowed us to improve the annotation of the Dm28c genome, identifying new ORFs and set the stage for construction of networks of co-expression, which can give clues about coded proteins of unknown functions. PMID:28286708

  5. Transcriptomic analysis reveals metabolic switches and surface remodeling as key processes for stage transition in Trypanosoma cruzi

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    Luisa Berná


    Full Text Available American trypanosomiasis is a chronic and endemic disease which affects millions of people. Trypanosoma cruzi, its causative agent, has a life cycle that involves complex morphological and functional transitions, as well as a variety of environmental conditions. This requires a tight regulation of gene expression, which is achieved mainly by post-transcriptional regulation. In this work we conducted an RNAseq analysis of the three major life cycle stages of T. cruzi: amastigotes, epimastigotes and trypomastigotes. This analysis allowed us to delineate specific transcriptomic profiling for each stage, and also to identify those biological processes of major relevance in each state. Stage specific expression profiling evidenced the plasticity of T. cruzi to adapt quickly to different conditions, with particular focus on membrane remodeling and metabolic shifts along the life cycle. Epimastigotes, which replicate in the gut of insect vectors, showed higher expression of genes related to energy metabolism, mainly Krebs cycle, respiratory chain and oxidative phosphorylation related genes, and anabolism related genes associated to nucleotide and steroid biosynthesis; also, a general down-regulation of surface glycoprotein coding genes was seen at this stage. Trypomastigotes, living extracellularly in the bloodstream of mammals, express a plethora of surface proteins and signaling genes involved in invasion and evasion of immune response. Amastigotes mostly express membrane transporters and genes involved in regulation of cell cycle, and also express a specific subset of surface glycoprotein coding genes. In addition, these results allowed us to improve the annotation of the Dm28c genome, identifying new ORFs and set the stage for construction of networks of co-expression, which can give clues about coded proteins of unknown functions.

  6. Dispersed cells represent a distinct stage in the transition from bacterial biofilm to planktonic lifestyles

    DEFF Research Database (Denmark)

    Chua, Song Lin; Liu, Yang; Yam, Joey Kuok Hoong


    Bacteria assume distinct lifestyles during the planktonic and biofilm modes of growth. Increased levels of the intracellular messenger c-di-GMP determine the transition from planktonic to biofilm growth, while a reduction causes biofilm dispersal. It is generally assumed that cells dispersed from...... biofilms immediately go into the planktonic growth phase. Here we use single-nucleotide resolution transcriptomic analysis to show that the physiology of dispersed cells from Pseudomonas aeruginosa biofilms is highly different from those of planktonic and biofilm cells. In dispersed cells, the expression...... of the small regulatory RNAs RsmY and RsmZ is downregulated, whereas secretion genes are induced. Dispersed cells are highly virulent against macrophages and Caenorhabditis elegans compared with planktonic cells. In addition, they are highly sensitive towards iron stress, and the combination of a biofilm...

  7. N-glycan transition of the early developmental stage in Oryza sativa. (United States)

    Horiuchi, Risa; Hirotsu, Naoki; Miyanishi, Nobumitsu


    N-Glycosylation is one of the post-translational modifications. In animals, N-glycans linked to proteins function in cell-cell recognition, sorting, transport, and other biological phenomena. However, in plants, N-glycan-mediated biological functions remain obscure. In a previous study, we showed that the main type of N-glycan transition is from the paucimannosidic to complex type before and after germination in Oryza sativa, suggesting that transitions of N-glycan, including those of glycoproteins and glycosyltransferases, are closely associated with plant growth. To further elucidate the relationship between N-glycan structure and plant growth, we analyzed the structures of N-glycans expressed in O. sativa seedlings grown under light conditions and performed comparative analyses of the structures in the shoot and root. The analyses show that fundamental N-glycan structures are common to the shoot and root, whereas paucimannosidic-type N-glycans dramatically decreased in the root grown under light conditions. Further, to investigate the effects of light on N-glycan structures in O. sativa seedlings, we analyzed N-glycan structures in O. sativa seedlings grown in the dark. Understandably, N-glycan expression in the root was almost unaffected by light. However, despite a marked difference in phenotype, N-glycan expression in the shoot was also unaffected by light. This result suggests that the shoot and root of O. sativa have different glycoproteins and distinct N-glycan synthetic systems. Thus, we propose that the N-glycan synthetic system of the O. sativa shoot is almost unaffected by light conditions and that many photosynthesis-related proteins are not modified by N-glycans.

  8. Phase equilibrium in argon films stabilized by homogeneous surfaces and thermodynamics of two-stage melting transition

    Energy Technology Data Exchange (ETDEWEB)

    Ustinov, E. A., E-mail: [Ioffe Physical Technical Institute, 26 Polytechnicheskaya, St. Petersburg 194021 (Russian Federation)


    Freezing of gases adsorbed on open surfaces (e.g., graphite) and in narrow pores is a widespread phenomenon which is a subject of a large number of publications. Modeling of the gas/liquid–solid transition is usually accomplished with a molecular simulation technique. However, quantitative analysis of the gas/liquid–solid coexistence and thermodynamic properties of the solid layer still encounters serious difficulties. This is mainly due to the effect of simulation box size on the lattice constant. Since the lattice constant is a function of loading and temperature, once the ordering transition has occurred, the simulation box size must be corrected in the course of simulation according to the Gibbs–Duhem equation. A significant problem is also associated with accurate prediction of the two-dimensional liquid–solid coexistence because of a small difference in densities of coexisting phases. The aim of this study is thermodynamic analysis of the two-dimensional phase coexistence in systems involving crystal-like free of defects layers in narrow slit pores. A special attention was paid to the determination of triple point temperatures. It is shown that intrinsic properties of argon monolayer adsorbed on the graphite surface are similar to those of isolated monolayer accommodated in the slit pore having width of two argon collision diameters. Analysis of the latter system is shown to be clearer and less time-consuming than the former one, which has allowed for explanation of the experimentally observed two-stage melting transition of argon monolayer on graphite without invoking the periodic surface potential modulation and orientational transition.

  9. The influence of the level of lamina propria invasion and the prevalence of p53 nuclear accumulation on survival in stage T1 transitional cell bladder cancer

    DEFF Research Database (Denmark)

    Hermann, G G; Horn, T; Steven, K


    related to age, level of lamina propria invasion and presence of p53 nuclear accumulation. For this subpopulation overall survival was 67%, and 79% for stage T1a, 70% for stage T1b and 57% for stage T1c (p positive (61......PURPOSE: We assessed the influence of the level of lamina propria invasion and the prevalence of p53 nuclear immunoreactivity on the survival of patients with stage T1 transitional cell bladder cancer. MATERIALS AND METHODS: All patients presenting with stage T1 bladder cancer were prospectively...... and routinely grouped according to the level of lamina propria invasion. Invasion of the tumor stalk was defined as stage T1a, invasion of the lamina propria proper superficial to the level of muscularis mucosa as stage T1b and into or deeper than the muscularis mucosa as stage T1c. The p53 nuclear...

  10. Prognostic factors of melanoma patients with satellite or in-transit metastasis at the time of stage III diagnosis.

    Directory of Open Access Journals (Sweden)

    Benjamin Weide

    Full Text Available BACKGROUND: Prognosis of patients with loco-regional skin metastases has not been analyzed in detail and the presence or absence of concurrent lymph node metastasis represents the only established prognostic factor thus far. Most studies were limited to patients already presenting with skin lesions at the time of initial diagnosis. We aimed to analyze the impact of a broad penal of prognostic factors in patients with skin metastases at the time of first metastatic spread, including patients with synchronous lesions already present at the time of initial diagnosis, stage I/II patients with loco-regional recurrence and patients initially presenting with skin metastasis but unknown primary melanoma. PATIENTS AND METHODS: We investigated disease-specific survival of 380 patients treated at our department between 1996 and 2010 using Kaplan Meier survival probabilities and Cox-proportional hazard analysis. RESULTS: Five-year survival probability was 60.1% for patients with skin metastases only and 36.3% for those with synchronous nodal metastases. The number of involved nodes and a tumor thickness of at least 3 mm had independent negative impact on prognosis. A strong relationship was identified between the risk of death and the number of involved nodes. Neither ulceration nor the timing of the first occurrence of metastases as either in stage I/II patients, at the time of excision of the primary melanoma or initially in patients with unknown primary tumor, had additional effects on survival. CONCLUSION: Lymph node involvement was confirmed as the most important prognostic factor for melanoma patients with loco-regional skin metastasis including those with unknown primary tumor and stage I/II patients with skin recurrence. Consideration of the tumor thickness and of the number of involved lymph nodes instead of the exclusive differentiation into presence vs. absence of nodal disease may allow a more accurate prediction of prognosis for patients with

  11. Steered molecular dynamics simulations of a type IV pilus probe initial stages of a force-induced conformational transition.

    Directory of Open Access Journals (Sweden)

    Joseph L Baker


    Full Text Available Type IV pili are long, protein filaments built from a repeating subunit that protrudes from the surface of a wide variety of infectious bacteria. They are implicated in a vast array of functions, ranging from bacterial motility to microcolony formation to infection. One of the most well-studied type IV filaments is the gonococcal type IV pilus (GC-T4P from Neisseria gonorrhoeae, the causative agent of gonorrhea. Cryo-electron microscopy has been used to construct a model of this filament, offering insights into the structure of type IV pili. In addition, experiments have demonstrated that GC-T4P can withstand very large tension forces, and transition to a force-induced conformation. However, the details of force-generation, and the atomic-level characteristics of the force-induced conformation, are unknown. Here, steered molecular dynamics (SMD simulation was used to exert a force in silico on an 18 subunit segment of GC-T4P to address questions regarding the nature of the interactions that lead to the extraordinary strength of bacterial pili. SMD simulations revealed that the buried pilin α1 domains maintain hydrophobic contacts with one another within the core of the filament, leading to GC-T4P's structural stability. At the filament surface, gaps between pilin globular head domains in both the native and pulled states provide water accessible routes between the external environment and the interior of the filament, allowing water to access the pilin α1 domains as reported for VC-T4P in deuterium exchange experiments. Results were also compared to the experimentally observed force-induced conformation. In particular, an exposed amino acid sequence in the experimentally stretched filament was also found to become exposed during the SMD simulations, suggesting that initial stages of the force induced transition are well captured. Furthermore, a second sequence was shown to be initially hidden in the native filament and became exposed upon

  12. River stage influences on uranium transport in a hydrologically dynamic groundwater-surface water transition zone: U TRANSPORT IN A GROUNDWATER-SURFACE WATER TRANSITION ZONE

    Energy Technology Data Exchange (ETDEWEB)

    Zachara, John M. [Pacific Northwest National Laboratory, Richland Washington USA; Chen, Xingyuan [Pacific Northwest National Laboratory, Richland Washington USA; Murray, Chris [Pacific Northwest National Laboratory, Richland Washington USA; Hammond, Glenn [Sandia National Laboratories, Albuquerque New Mexico USA


    A tightly spaced well-field within a groundwater uranium (U) plume in the groundwater-surface water transition zone was monitored for a three year period for groundwater elevation and dissolved solutes. The plume discharges to the Columbia River, which displays a dramatic spring stage surge resulting from mountain snowmelt. Groundwater exhibits a low hydrologic gradient and chemical differences with river water. River water intrudes the site in spring. Specific aims were to assess the impacts of river intrusion on dissolved uranium (Uaq), specific conductance (SpC), and other solutes, and to discriminate between transport, geochemical, and source term heterogeneity effects. Time series trends for Uaq and SpC were complex and displayed large temporal well-to well variability as a result of water table elevation fluctuations, river water intrusion, and changes in groundwater flow directions. The wells were clustered into subsets exhibiting common temporal behaviors resulting from the intrusion dynamics of river water and the location of source terms. Concentration hot spots were observed in groundwater that varied in location with increasing water table elevation. Heuristic reactive transport modeling with PFLOTRAN demonstrated that mobilized U was transported between wells and source terms in complex trajectories, and was diluted as river water entered and exited the groundwater system. While uranium time-series concentration trends varied significantly from year to year as a result of climate-caused differences in the spring hydrograph, common and partly predictable response patterns were observed that were driven by water table elevation, and the extent and duration of the river water intrusion event.

  13. Beyond the adoption/ non-adoption dichotomy: the impact of innovation characteristics on potential adopters' transition through adoption process stages

    NARCIS (Netherlands)

    Agarwal, M.K.; Frambach, R.T.


    Research on innovation adoption has suffered from a bias towards understanding the factors that affect the dichotomous adoption/non-adoption decision.Much less attention is devoted to the question why potential adopters fail to progress to the adoption stage from earlier stages in the decision makin

  14. Implied Reader Response and the Evolution of Genres: Transitional Stages Between the Ancient Novels and the Apocryphal Acts

    Directory of Open Access Journals (Sweden)

    Robert M. Price


    Full Text Available This article aims at elaborating on the commonly held judgment that the Apocryphal Acts of the Apostles have somehow been influenced by the Hellenistic novels. It is argued that the one evolved from the other. Three stages can be traced. A first stage consists of Christian allegorizing of the novels based on the many striking crucifixion and empty tomb passages, followed by a second stage of writing Christian allegories based on the Old Testament heritage of Christianity. Joseph and Asenath being the sole surviving example. Finally, the third stage is the explicit composing of Christian versions of the picaresque romantic adventure novels, namely the Apocryphal Acts.

  15. Comprehensive Research on Essential Oil and Phenolic Variation in Different Foeniculum vulgare Populations During Transition from Vegetative to Reproductive Stage. (United States)

    Salami, Maryam; Rahimmalek, Mehdi; Ehtemam, Mohammad Hossein


    Chemical composition and antioxidant activity of four fennel populations (England, Spain, Poland and Iran) were investigated during six developmental stages including two vegetative and four reproductive phases. In reproductive phase, the essential oil content of fruits decreased and the maximum content (5.9%) was obtained in immediate fruits. The essential oils were analyzed using GC/MS. trans-Anethole was the main component of the leaves and the fruits oil. In leaves, it ranged from 41.28% in England at late vegetative stage to 56.6% in Poland population at early vegetative stage. Other major compounds of leaves were limonene, α-pinene and (Z)-β-ocimene. In reproductive phases the trans-anethole increased dramatically. It varied from 85.25% in immature fruits from Poland to 90.7% in pre-mature stage from Spain. The highest phenolic content in the extracts at different growth stages obtained 189 mg TAE/g DW at full mature stage of seed in Iran population. The flavonoid of leaves extract ranged from 3 to 7.5 mg QUE/g DW, while in fruits extract varied from 3 to 10.3 mg QUE/g DW. Antioxidant activity of the extracts was evaluated using 1,1-diphenyl-2-picrylhydrazy (DPPH) and β-carotene model systems. Immature and full mature growth stages of fennel population from Spain indicated the highest activity in quenching of DPPH radical (74.2% and 74.5, respectively). Antioxidant activities of the extracts had high positive correlation with their phenolic contents in all fruit maturity stages. Finally, it might probably be suggested that in fennel the hot and humid condition can lead to increase trans-anethole, while the hot and dry one can produce higher amount of phenolics and flavonoids.

  16. Transition from hopeless dentition to full-arch fixed-implant-supported rehabilitation by a staged extraction approach: rationale and technique. (United States)

    Mijiritsky, Eitan; Mazor, Ziv; Lorean, Adi; Mortellaro, Carmen; Mardinger, Ofer; Levin, Liran


    Transition from a hopeless dentition to a fixed-implant-supported full-arch reconstruction can be difficult for patients if wearing a transitional removable denture is involved. In addition, an increased risk for trauma to bone augmentation areas and to the implant-bone interface exists when using a removable transitional complete denture during the implant healing period; such risk can compromise implant success or increase crestal bone loss around implants before the final restoration. This article describes a treatment approach that allows replacement of the hopeless dentition with an osseointegrated fixed prosthesis, without rendering the patient totally edentulous before the delivery of the final implant-supported prosthesis. A staged approach using a few hopeless teeth to support a provisional fixed restoration during the healing process can help avoid discomfort and improve implants' outcome. A treatment plan for a maxillary arch reconstruction is used to illustrate the staged approach protocol. This protocol addresses patients' psychologic need to remain dentate during partial or full-mouth rehabilitation, while providing good esthetics and function during restoration of a dental arch.

  17. Transformation of Zaporozhian Cossack Elites: Reasons and Stages of Sich and Cossack Army Transition to the Autonomous Elective Administration in Early XVII Century

    Directory of Open Access Journals (Sweden)

    Igor A. Melnichuk


    Full Text Available The article presents brief historic and political analysis of reasons and stages of transition of political positions of Zaporozhian Sich Cossack starshyna towards elective administration, independent of Poland in the first decades of the XVII century. The conclusion was made that the detailed hierarchy of Cossack authorities in terms of periodic rotation and reporting of all its levels, formation of personal foreign-policy priorities and autonomous aspirations, independent of Polish official position in starshynskaya elite were formed in this period

  18. A novel two-stage Lagrangian decomposition approach for refinery production scheduling with operational transitions in mode switching☆

    Institute of Scientific and Technical Information of China (English)

    Lei Shi; Yongheng Jiang; Ling Wang; Dexian Huang


    To address large scale industrial processes, a novel Lagrangian scheme is proposed to decompose a refinery scheduling problem with operational transitions in mode switching into a production subproblem and a blending and delivery subproblem. To accelerate the convergence of Lagrange multipliers, some auxiliary constraints are added in the blending and delivery subproblem. A speed-up scheme is presented to increase the efficiency for solving the production subproblem. An initialization scheme of Lagrange multipliers and a heuristic algorithm to find feasible solutions are designed. Computational results on three cases with different lengths of time hori-zons and different numbers of orders show that the proposed Lagrangian scheme is effective and efficient.

  19. Msx1 and Tbx2 antagonistically regulate Bmp4 expression during the bud-to-cap stage transition in tooth development. (United States)

    Saadi, Irfan; Das, Pragnya; Zhao, Minglian; Raj, Lakshmi; Ruspita, Intan; Xia, Yan; Papaioannou, Virginia E; Bei, Marianna


    Bmp4 expression is tightly regulated during embryonic tooth development, with early expression in the dental epithelial placode leading to later expression in the dental mesenchyme. Msx1 is among several transcription factors that are induced by epithelial Bmp4 and that, in turn, are necessary for the induction and maintenance of dental mesenchymal Bmp4 expression. Thus, Msx1(-/-) teeth arrest at early bud stage and show loss of Bmp4 expression in the mesenchyme. Ectopic expression of Bmp4 rescues this bud stage arrest. We have identified Tbx2 expression in the dental mesenchyme at bud stage and show that this can be induced by epithelial Bmp4. We also show that endogenous Tbx2 and Msx1 can physically interact in mouse C3H10T1/2 cells. In order to ascertain a functional relationship between Msx1 and Tbx2 in tooth development, we crossed Tbx2 and Msx1 mutant mice. Our data show that the bud stage tooth arrest in Msx1(-/-) mice is partially rescued in Msx1(-/-);Tbx2(+/-) compound mutants. This rescue is accompanied by formation of the enamel knot (EK) and by restoration of mesenchymal Bmp4 expression. Finally, knockdown of Tbx2 in C3H10T1/2 cells results in an increase in Bmp4 expression. Together, these data identify a novel role for Tbx2 in tooth development and suggest that, following their induction by epithelial Bmp4, Msx1 and Tbx2 in turn antagonistically regulate odontogenic activity that leads to EK formation and to mesenchymal Bmp4 expression at the key bud-to-cap stage transition.

  20. Molecular changes in Opisthorchis viverrini (Southeast Asian liver fluke during the transition from the juvenile to the adult stage.

    Directory of Open Access Journals (Sweden)

    Aaron R Jex

    Full Text Available BACKGROUND: The Southeast Asian liver fluke (Opisthorchis viverrini chronically infects and affects tens of millions of people in regions of Asia, leading to chronic illness and, importantly, inducing malignant cancer (= cholangiocarcinoma. In spite of this, little is known, at the molecular level, about the parasite itself, its interplay with its hosts or the mechanisms of disease and/or carcinogenesis. METHODOLOGY/PRINCIPAL FINDINGS: Here, we generated extensive RNA-Seq data (Illumina representing adult and juvenile stages of O. viverrini, and combined these sequences with previously published transcriptomic data (454 technology for this species, yielding a combined assembly of significantly increased quality and allowing quantitative assessment of transcription in the juvenile and adult stage. CONCLUSIONS: This enhanced assembly reveals that, despite the substantial biological similarities between the human liver flukes, O. viverinni and Clonorchis sinensis, there are previously unrecognized differences in major aspects of their molecular biology. Most notable are differences among the C13 and cathepsin L-like cysteine peptidases, which play key roles in tissue migration, immune evasion and feeding, and, thus, represent potential drug and/or vaccine targets. Furthermore, these data indicate that major lineages of cysteine peptidases of socioeconomically important trematodes have evolved through a process of gene loss rather than independent radiation, contrasting previous proposals.

  1. Transition of Plasmodium sporozoites into liver stage-like forms is regulated by the RNA binding protein Pumilio

    KAUST Repository

    Gomes-Santos, Carina S. S.


    Many eukaryotic developmental and cell fate decisions that are effected post-transcriptionally involve RNA binding proteins as regulators of translation of key mRNAs. In malaria parasites (Plasmodium spp.), the development of round, non-motile and replicating exo-erythrocytic liver stage forms from slender, motile and cell-cycle arrested sporozoites is believed to depend on environmental changes experienced during the transmission of the parasite from the mosquito vector to the vertebrate host. Here we identify a Plasmodium member of the RNA binding protein family PUF as a key regulator of this transformation. In the absence of Pumilio-2 (Puf2) sporozoites initiate EEF development inside mosquito salivary glands independently of the normal transmission-associated environmental cues. Puf2- sporozoites exhibit genome-wide transcriptional changes that result in loss of gliding motility, cell traversal ability and reduction in infectivity, and, moreover, trigger metamorphosis typical of early Plasmodium intra-hepatic development. These data demonstrate that Puf2 is a key player in regulating sporozoite developmental control, and imply that transformation of salivary gland-resident sporozoites into liver stage-like parasites is regulated by a post-transcriptional mechanism. 2011 Gomes-Santos et al.

  2. Transition of Plasmodium sporozoites into liver stage-like forms is regulated by the RNA binding protein Pumilio.

    Directory of Open Access Journals (Sweden)

    Carina S S Gomes-Santos


    Full Text Available Many eukaryotic developmental and cell fate decisions that are effected post-transcriptionally involve RNA binding proteins as regulators of translation of key mRNAs. In malaria parasites (Plasmodium spp., the development of round, non-motile and replicating exo-erythrocytic liver stage forms from slender, motile and cell-cycle arrested sporozoites is believed to depend on environmental changes experienced during the transmission of the parasite from the mosquito vector to the vertebrate host. Here we identify a Plasmodium member of the RNA binding protein family PUF as a key regulator of this transformation. In the absence of Pumilio-2 (Puf2 sporozoites initiate EEF development inside mosquito salivary glands independently of the normal transmission-associated environmental cues. Puf2- sporozoites exhibit genome-wide transcriptional changes that result in loss of gliding motility, cell traversal ability and reduction in infectivity, and, moreover, trigger metamorphosis typical of early Plasmodium intra-hepatic development. These data demonstrate that Puf2 is a key player in regulating sporozoite developmental control, and imply that transformation of salivary gland-resident sporozoites into liver stage-like parasites is regulated by a post-transcriptional mechanism.

  3. Transitional change in rat fetal cell proliferation in response to ghrelin and des-acyl ghrelin during the last stage of pregnancy

    Energy Technology Data Exchange (ETDEWEB)

    Inoue, Yoshiyuki; Nakahara, Keiko [Department of Veterinary Physiology, Faculty of Agriculture, University of Miyazaki, Miyazaki 889-2192 (Japan); Kangawa, Kenji [Department of Biochemistry, National Cardiovascular Center Research Institute, Fujishirodai 5-7-1, Suita, Osaka 565-8565 (Japan); Murakami, Noboru, E-mail: [Department of Veterinary Physiology, Faculty of Agriculture, University of Miyazaki, Miyazaki 889-2192 (Japan)


    Expression of mRNA for the ghrelin receptor, GHS-R1a, was detected in various peripheral and central tissues of fetal rats, including skin, bone, heart, liver, gut, brain and spinal cord, on embryonic day (ED)15 and ED17. However, its expression in skin, bone, heart and liver, but not in gut, brain and spinal cord, became relatively weak on ED19 and disappeared after birth (ND2). Ghrelin and des-acyl ghrelin facilitated the proliferation of cultured fetal (ED17, 19), but not neonatal (ND2), skin cells. On the other hand, with regard to cells from the spinal cord and hypothalamus, the proliferative effect of ghrelin continued after birth, whereas the effect of des-acyl ghrelin on neurogenesis in these tissues was lost at the ED19 fetal and ND2 neonatal stages. Immunohistochemistry revealed that the cells in the hypothalamus induced to proliferate by ghrelin at the ND2 stage were positive for nestin and glial fibrillary acidic protein. These results suggest that in the period immediately prior to, and after birth, rat fetal cells showing proliferation in response to ghrelin and des-acyl ghrelin are at a transitional stage characterized by alteration of the expression of GHS-R1a and an undefined des-acyl ghrelin receptor, their responsiveness varying among different tissues.

  4. Structural characteristics of transition-iron-carbide precipitates formed during the first stage of tempering in 4340 steel

    Energy Technology Data Exchange (ETDEWEB)

    Thompson, S.W.


    Microstructural and crystallographic characteristics of fine-scale transition-iron-carbide precipitates formed in martensite during tempering of 4340 steel at 200 °C for 3.6 ks were studied via transmission electron microscopy. Precipitates of near-equiaxed shapes and about 10 nm in size were observed, and rows of closely spaced precipitates were aligned predominantly along < 100 > martensite directions. Aggregates of aligned precipitates were up to 150 nm in length, although occasional kinks were present that disrupted the alignment, and some of the adjacent precipitates possessed somewhat different crystallographic orientations. Electron-diffraction results were analyzed in detail and found to be consistent with both epsilon-carbide and eta-carbide phases. Similarities between these two phases were highlighted and discussed. Experimental electron-diffraction data were compared with data from five different unit cells, and each was found to be consistent within uncertainty ranges of ± 0.003 nm for interplanar spacings, ± 2° for angles between plane normals, and a few degrees for the orientation relationship between precipitates and the matrix.

  5. 隐忍以行,厚积薄发--阿赫玛托娃创作转折期探究%Profound Accumulation, Great Transition---On the Transitional Stage of Akhmatova’s Creation

    Institute of Scientific and Technical Information of China (English)



    The period from 1920 s to 1930 s is an important transitional stage for Akhmatova’s poetry creation, which serves as a turning point for the change of themes and maturity of thought.In detail, they are embodied in the gradual deepening of poetry themes, the influence from Pushkin and the innovations of Akhmatova.%20世纪二三十年代是阿赫玛托娃创作的重要转折期,这段时间对其整个文风的转变、思想的成熟具有承前启后、不断开拓的作用。主要体现在诗歌题材的逐步深化和对普希金的继承与突破等方面。

  6. Inhibitory Effect of Recombinant Fibronectin Polypeptide CH50 on Invasion and Metastasis of Melanoma B16 Cells

    Institute of Scientific and Technical Information of China (English)

    WEI Jia; XIONG Yiquan


    In order to investigate the inhibitory effect and mechanism of recombinant polypeptide CH50 on invasion and metastasis of melanoma B16 cells, the recombinant polypeptide CH50 was separated and purified by ion exchange chromatographic technique. The melanoma B 16 cells treated with purified CH50 were cultured in vitro, the number was counted at 4, 24, 48 and 72 h and their morphological changes were observed in order to detect their adhesion and spreading abilities. In in vivo study, the melanoma B16 cells were labeled with CFSE and treated with CH50 and then they were injected into mice via mouse-tail veins. After 5 h, the lung tissues were fixed by frozen section. Accumulation and invasion abilities of B 16 cells on lung tissues were observed under the fluorescent microscopy. The results showed that the morphological character of B 16 cells treated with CH50 changed greatly and the number of B16 cells treated with CH50 decreased significantly (P<0.05). The adhesion and spreading abilities of B16 cells treated with CH50 were weakened obviously and the metastasis foci on lung tissues reduced. It was concluded that the recombinant polypeptide CH50 inhibited invasion and metastasis of melanoma B16 cells on tissues and could be a prospective bio-product in tumor general therapy.

  7. Single-cell mass spectrometry reveals small molecules that affect cell fates in the 16-cell embryo. (United States)

    Onjiko, Rosemary M; Moody, Sally A; Nemes, Peter


    Spatial and temporal changes in molecular expression are essential to embryonic development, and their characterization is critical to understand mechanisms by which cells acquire different phenotypes. Although technological advances have made it possible to quantify expression of large molecules during embryogenesis, little information is available on metabolites, the ultimate indicator of physiological activity of the cell. Here, we demonstrate that single-cell capillary electrophoresis-electrospray ionization mass spectrometry is able to test whether differential expression of the genome translates to the domain of metabolites between single embryonic cells. Dissection of three different cell types with distinct tissue fates from 16-cell embryos of the South African clawed frog (Xenopus laevis) and microextraction of their metabolomes enabled the identification of 40 metabolites that anchored interconnected central metabolic networks. Relative quantitation revealed that several metabolites were differentially active between the cell types in the wild-type, unperturbed embryos. Altering postfertilization cytoplasmic movements that perturb dorsal development confirmed that these three cells have characteristic small-molecular activity already at cleavage stages as a result of cell type and not differences in pigmentation, yolk content, cell size, or position in the embryo. Changing the metabolite concentration caused changes in cell movements at gastrulation that also altered the tissue fates of these cells, demonstrating that the metabolome affects cell phenotypes in the embryo.

  8. Non-linear recurrence analysis of NREM human sleep microstructure discloses deterministic oscillation patterns related to sleep stage transitions and sleep maintenance. (United States)

    Priano, L; Saccomandi, F; Mauro, A; Guiot, C


    Sleep is a dynamic process aimed at obtaining the required neurophysiological states at certain times, according to circadian and homeostatic needs and despite external or internal interfering stimuli. In this context, peculiar transient synchronized EEG patterns (TSEP) are supposed to play the main role in the building up of EEG synchronization and in the flexible adaptation against perturbations Our study aimed at disclosing and quantifying attractor driven, hidden periodicity or, conversely, chaotic oscillation patterns in the series of these TSEP related to sleep stage transitions and sleep maintenance. At first we devised a multistep algorithm, able to capture TSEP from EEG during sleep in 10 healthy volunteers. The time series of TSEP were then analyzed according to the Recurrence Plot (RP). TSEP series showed to form a pseudo-periodic series which becomes progressively denser and more stable until steady slow wave NREM sleep is reached, but looses stability just before REM sleep starts. This suggests that deterministic oscillatory patterns maybe adequate descriptors of the balance between homeostatic needs for NREM sleep and REM sleep pressure, supported by different cortical neuronal populations interactions.

  9. A homologue of the yeast SHE4 gene is essential for the transition between the syncytial and cellular stages during sexual reproduction of the fungus Podospora anserina. (United States)

    Berteaux-Lecellier, V; Zickler, D; Debuchy, R; Panvier-Adoutte, A; Thompson-Coffe, C; Picard, M


    The Podospora anserina cro1 gene was identified as a gene required for sexual sporulation. Crosses homozygous for the cro1-1 mutation yield fruiting bodies which produce few asci due to the formation of giant plurinucleate cells instead of dikaryotic cells after fertilization. This defect does not impair karyogamy, but meioses of the resultant polyploid nuclei are most often abortive. Cytological studies suggest that the primary defect of the mutant is its inability to form septa between the daughter nuclei after each mitosis, a step specific for normal dikaryotic cell divisions. The cro1-1 mutant would thus be unable to leave the syncytial vegetative state while abiding by the meiotic programme. cro1-1 also shows defects in ascospore germination and growth rate. GFP-tagging of the CRO1 protein reveals that it is a cytosolic protein mainly expressed at the beginning of the dikaryotic stage and at the time of ascospore maturation. The CRO1 protein exhibits significant similarity to the SHE4 protein, which is required for asymmetric mating-type switching in budding yeast cells. Thus, a gene involved in asymmetric cell divisions in a unicellular organism plays a key role at the transition between the syncytial (vegetative) state and the cellular (sexual) state in a filamentous fungus. PMID:9482722

  10. 可变线路式公交的两阶段车辆调度模型%Two-stage model for flex-route transit scheduling

    Institute of Scientific and Technical Information of China (English)

    邱丰; 李文权; 沈金星


    A two-stage scheduling model is designed for the flex-route transit to deal with predeter-mined requests and real-time requests.An optimal model for the vehicle routing problem,which minimizes passenger travel costs and vehicle operating costs,is built as the first-stage scheduling model to serve predetermined requests.The simulated annealing algorithm is developed to solve the first-stage model and an initial vehicle routing plan can be obtained.The second-stage scheduling model is established for real-time requests,and four types of passengers are arranged into the vehicle routing plan through the heuristic insertion algorithm.The simulation experiments based on a realistic case demonstrate the feasibility of this two-stage scheduling model,and the results indicate that there would be a better system performance if more passengers choose to make appointments for flex-route service.There is approximately a 10%improvement in system performance when demand reaches 25 passenger/h and 70%of passengers make appointments,compared with the scenario under pure real-time passenger demand.%针对可变线路式公交设计了一种可同时处理预约需求和实时需求的两阶段车辆调度模型。第1阶段模型以预约需求为服务对象,建立了以乘客出行成本和车辆运营成本最小为目标的路径优化模型,采用模拟退火算法对模型进行求解,获得车辆初始行驶路径方案。第2阶段模型以实时需求为服务目标,在原定行驶路径方案上利用启发式插入算法将4类乘客排入车辆行车计划中。基于实例的仿真试验验证了两阶段车辆调度模型的可行性,结果表明:通过提高乘客预约出行比例的方式可提升系统性能,本例中当乘客需求量达到25人/h、预约出行比例达到70%时,系统整体性能相较于纯动态需求条件下提升近10%。


    Energy Technology Data Exchange (ETDEWEB)



    In this paper we use London Langevin molecular dynamics simulations to investigate the vortex matter melting transition in the highly anisotropic high-temperature superconductor material Bi{sub 2}Sr{sub 2}CaCu{sub 2}O{sub 8+{delta}} in the presence of low concentration of columnar defects (CDs). We reproduce with further details our previous results obtained by using Multilevel Monte Carlo simulations that showed that the melting of the nanocrystalline vortex matter occurs in two stages: a first stage melting into nanoliquid vortex matter and a second stage delocalization transition into a homogeneous liquid. Furthermore, we report on new dynamical measurements in the presence of a current that identifies clearly the irreversibility line and the second stage delocalization transition. In addition to CDs aligned along the c-axis we also simulate the case of tilted CDs which are aligned at an angle with respect to the applied magnetic field. Results for CDs tilted by 45{degree} with respect to c-axis show that the locations of the melting and delocalization transitions are not affected by the tilt when the ratio of flux lines to CDs remains constant. On the other hand we argue that some dynamical properties and in particular the position of the irreversibility line should be affected.

  12. Altered snowfall and soil disturbance influence the early life stage transitions and recruitment of a native and invasive grass in a cold desert. (United States)

    Gornish, Elise S; Aanderud, Zachary T; Sheley, Roger L; Rinella, Mathew J; Svejcar, Tony; Englund, Suzanne D; James, Jeremy J


    Climate change effects on plants are expected to be primarily mediated through early life stage transitions. Snowfall variability, in particular, may have profound impacts on seedling recruitment, structuring plant populations and communities, especially in mid-latitude systems. These water-limited and frequently invaded environments experience tremendous variation in snowfall, and species in these systems must contend with harsh winter conditions and frequent disturbance. In this study, we examined the mechanisms driving the effects of snowpack depth and soil disturbance on the germination, emergence, and establishment of the native Pseudoroegnaria spicata and the invasive Bromus tectorum, two grass species that are widely distributed across the cold deserts of North America. The absence of snow in winter exposed seeds to an increased frequency and intensity of freeze-thaw cycles and greater fungal pathogen infection. A shallower snowpack promoted the formation of a frozen surface crust, reducing the emergence of both species (more so for P. spicata). Conversely, a deeper snowpack recharged the soil and improved seedling establishment of both species by creating higher and more stable levels of soil moisture availability following spring thaw. Across several snow treatments, experimental disturbance served to decrease the cumulative survival of both species. Furthermore, we observed that, regardless of snowpack treatment, most seed mortality (70-80%) occurred between seed germination and seedling emergence (November-March), suggesting that other wintertime factors or just winter conditions in general limited survival. Our results suggest that snowpack variation and legacy effects of the snowpack influence emergence and establishment but might not facilitate invasion of cold deserts.

  13. Petrogenesis of Neoarchean metavolcanic rocks in Changyukou, Northwestern Hebei: Implications for the transition stage from a compressional to an extensional regime for the North China Craton (United States)

    Liou, Peng; Shan, Houxiang; Liu, Fu; Guo, Jinghui


    fractional crystallization of basaltic andesites (high-Al basalts) and andesites. Mixing of magmas at various stages along the fractionation course of basaltic andesites (high-Al basalts) toward rhyolites promotes the trend of the calc-alkaline series. To reconcile the 2.55 to 2.5 Ga TTGs derived from overthickened crust, the 2.51 to 2.50 Ga calc-alkaline volcanic rocks derived from thickened crust, tholeiitic basalts representing low pressure and an extensional tectonic setting, 2493 Ma leucosyenogranites derived from overthickened crust, 2437 Ma biotite-monzogranites derived from slightly thinner crust than leucosyenogranites but still thickened, as well as the clockwise hybrid ITD and IBC P-T paths of the HP granulites and widespread extension and rifting setting within the NCC from 2300 Ma, we propose a model of an evolving subduction process. Among them, the composition of the 2.5 Ga Changyukou volcanic rocks and potassic granites as well as the clockwise hybrid ITD and IBC P-T paths of the HP granulites may reveal that the tectonic setting in Northwest Hebei was in a transition stage from a subduction-related compressional regime to an extensional regime related to plate rollback.

  14. AFSC/RACE/SAP/Long: Data from: A novel quantitative model of multiple discrete stage transitions applied to crustacean larval development (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set describes the holding temperatures and developmental stages of larvae of red and blue king crab (Paralithodes camtschaticus and P. platypus) reared to...

  15. Observed degradation stages of ring-mold craters (RMC): Geomorphic evidence for modification of ice-rich deposits in the transitions zone between Elysium and Utopia Basin, Mars

    DEFF Research Database (Denmark)

    Pedersen, Gro Birkefeldt Møller

    Deposits with pits, depressions and RMCs observed north of Elysium rise are interpreted as degraded mixtures of ice and clastic material (CCF, LVF and LDA). Degradation stages of RMCs are an important tool for mapping dusty, deflated ice-rich units....

  16. Enamel pits in hamster molars, formed by a single high fluoride dose, are associated with a perturbation of transitional stage ameloblasts

    NARCIS (Netherlands)

    Lyaruu, D.M.; Vermeulen, L.; Stienen, N.; Bervoets, T.J.M.; Denbesten, P.K.; Bronckers, A.L.J.J.


    Excessive intake of fluoride (F) by young children results in the formation of enamel subsurface porosities and pits, called enamel fluorosis. In this study, we used a single high dose of F administered to hamster pups to determine the stage of ameloblasts most affected by F and whether pit formatio

  17. Role of histamine H3 receptor in glucagon-secreting αTC1.6 cells. (United States)

    Nakamura, Tadaho; Yoshikawa, Takeo; Naganuma, Fumito; Mohsen, Attayeb; Iida, Tomomitsu; Miura, Yamato; Sugawara, Akira; Yanai, Kazuhiko


    Pancreatic α-cells secrete glucagon to maintain energy homeostasis. Although histamine has an important role in energy homeostasis, the expression and function of histamine receptors in pancreatic α-cells remains unknown. We found that the histamine H3 receptor (H3R) was expressed in mouse pancreatic α-cells and αTC1.6 cells, a mouse pancreatic α-cell line. H3R inhibited glucagon secretion from αTC1.6 cells by inhibiting an increase in intracellular Ca(2+) concentration. We also found that immepip, a selective H3R agonist, decreased serum glucagon concentration in rats. These results suggest that H3R modulates glucagon secretion from pancreatic α-cells.

  18. Transition of historial tube flaps to free flap for 2-stage total knee arthroplasty in a patient with a history of Gustilo grade IIIB tibia fracture. (United States)

    Spence, Sean A; Doren, Erin L; Dayicioglu, Deniz; Bernasek, Thomas


    We report the case of a 56-year-old patient who had posttraumatic bilateral knee arthritis and underwent sequential bilateral total knee arthroplasty (TKA). The left knee joint required 2-stage reconstruction: a free flap for enhanced soft-tissue coverage and then left knee TKA. Uniquely, at age 16 years this patient sustained a left tibia grade IIIB high-energy crush injury in a car crash and underwent reconstruction with multiple pedicle tube flaps and transfer of soft tissues. Most of that reconstruction was done between the ages of 16 and 19. At age 56 years, staged TKA was performed. To our knowledge, this is the first report of a knee reconstructed with pedicle tube flaps for a grade IIIB tibial fracture, followed years later by free-flap coverage before TKA. This report offers insights and treatment recommendations through long-term follow-up of a unique case and a historical perspective on how reconstructive options have evolved.

  19. Structurally functional model of socially valuable behavior of children at the stage of transition from the senior preschool age to primary school age

    Directory of Open Access Journals (Sweden)

    Elvira Bakhteeva


    Full Text Available The author analyses the transition period from the senior preschool age to primary school age as optimum for development of preconditions of stable social behavior of the child. Special attention is given to the background of leading value of children's subculture in formation of experience of social behavior of 5–7 year old children. On the basis of the research, carried out by the author, the essence of the concept “socially-valuable behavior” is revealed. The components and structurally functional model of socially-valuable behavior are presented.

  20. Transition from failing dentition to full-arch fixed implant-supported prosthesis with a staged approach using removable partial dentures: a case series. (United States)

    Cortes, Arthur Rodriguez Gonzalez; Cortes, Djalma Nogueira; No-Cortes, Juliana; Arita, Emiko Saito


    The present retrospective case series is aimed at evaluating a staged approach using a removable partial denture (RPD) as an interim prosthesis in treatment to correct a failing dentition until such time as a full-arch fixed implant-supported prosthesis may be inserted. Eight patients, who had undergone maxillary full-arch rehabilitation with dental implants due to poor prognosis of their dentitions, were analyzed. All treatment included initial periodontal therapy and a strategic order of extraction of hopeless teeth. An RPD supported by selected teeth rehabilitated the compromised arch during implant osseointegration. These remaining teeth were extracted prior to definitive prosthesis delivery. Advantages and drawbacks of this technique were also recorded for the cases presented. Among the advantages provided by the staged approach are simplicity of fabrication, low cost, and ease of insertion. Additionally, RPD tooth support prevented contact between the interim prosthesis and healing abutments, promoting implant osseointegration. The main drawbacks were interference with speech and limited esthetic results. Implant survival rate was 100% within a follow-up of at least 1 year. The use of RPDs as interim prostheses allowed for the accomplishment of the analyzed rehabilitation treatments. It is a simple treatment alternative for patients with a low smile line.

  1. A Three-section Algorithm of Dynamic Programming Based on Three-stage Decomposition System Model for Grade Transition Trajectory Optimization Problems

    Institute of Scientific and Technical Information of China (English)

    Yujie Wei; Yongheng Jiang; Dexian Huang⁎


    This paper introduces a practical solving scheme of gradetransition trajectory optimization (GTTO) problems under typical certificate-checking–updating framework. Due to complicated kinetics of polymerization, differential/algebraic equations (DAEs) always cause great computational burden and system non-linearity usual y makes GTTO non-convex bearing multiple optima. Therefore, coupled with the three-stage decomposi-tion model, a three-section algorithm of dynamic programming (TSDP) is proposed based on the general iteration mechanism of iterative programming (IDP) and incorporated with adaptivegrid allocation scheme and heuristic modifications. The algorithm iteratively performs dynamic programming with heuristic modifications under constant calculation loads and adaptively allocates the valued computational resources to the regions that can further improve the optimality under the guidance of local error estimates. TSDP is finally compared with IDP and interior point method (IP) to verify its efficiency of computation.


    Directory of Open Access Journals (Sweden)

    Olga E. Bashina


    Full Text Available The article is dedicated to the actual economic problem of decision-making for management. Decision support systems (DSS belong to a class of information systems which are set of toolkits for supporting such processes as creating choices and making (selecting a decision. These systems contain tools for combining management both on strategic and operative levels with advanced analytics. Such information systems based on different tools for supporting all stages of decision making and implementation are of current importance and in demand. In the article there is a result of analyses of current methods and computer tools used for decision support. DSS are of particular importance in the network economy as an integral part of information society development where the speed of decision making is a key success factor.

  3. Appreciable Problems in Construction Stage of Urban Rail Transit from the Operation Angle%从运营角度分析城市轨道交通建设阶段需重视的问题

    Institute of Scientific and Technical Information of China (English)



    分析了城市轨道交通网络化运营面临的主要问题,从运营角度提出了建设阶段必须关注的总体设计、标准化设计、国产化和信息化等问题.分析了忽视这些问题对网络化运营的安全性、可靠性和效率的影响,阐述了总体设计、标准化设计、国产化设计和信息化设计在建设阶段应关注的重点.%The main problems facing urban rail transit network operation are analyzed, an overall design, the standard design, localization and information technology are emphasized in the construction stage from the operation angle. Since the effect of these problems to the security, reliability and efficiency of networking operation are often neglected, more attention should be given to them in the whole construction stage, including the overall design, standard design, localization design and information design.

  4. Well staged

    Energy Technology Data Exchange (ETDEWEB)

    Budd, Godfrey


    Packers Plus Energy Services Inc. has commercially launched QuickFRAC, a multi-stage completition system which can fracture four to five isolated stages in one treatment and set up a record of 23-stage slickwater frac in less than 10 hours. It could take up to 40 days to do 100 fracture treatments with other systems. This technology makes it possible to distribute fluid at each port thanks to the limited entry system. In order to make multiple isolated stages within one treatment zone, each zone includes multiple QuickPORT sleeves with packers on either side. The other technology which made this possible is the repeater port system, it allows them to perform more frac stages. This technology could be useful in the future since the need for stages will be doubling soon with microdarcy shale oil extraction which is more difficult than gas.

  5. Trading stages

    DEFF Research Database (Denmark)

    Steiner, Uli; Tuljapurkar, Shripad; Coulson, Tim


    Interest in stage-and age structured models has recently increased because they can describe quantitative traits such as size that are left out of age-only demography. Available methods for the analysis of effects of vital rates on lifespan in stage-structured models have not been widely applied ...... examples. Much of our approach relies on trading of time and mortality risk in one stage for time and risk in others. Our approach contributes to the new framework of the study of age- and stage-structured biodemography....

  6. Staging atmospheres

    DEFF Research Database (Denmark)

    Bille, Mikkel; Bjerregaard, Peter; Sørensen, Tim Flohr


    The article introduces the special issue on staging atmospheres by surveying the philosophical, political and anthropological literature on atmosphere, and explores the relationship between atmosphere, material culture, subjectivity and affect. Atmosphere seems to occupy one of the classic...... localities of tensions between matter and the immaterial, the practical and the ideal, and subject and object. In the colloquial language there can, moreover, often seem to be something authentic or genuine about atmosphere, juxtaposing it to staging, which is implied to be something simulated or artificial....... This introduction seeks to outline how a number of scholars have addressed the relationship between staged atmospheres and experience, and thus highlight both the philosophical, social and political aspects of atmospheres...

  7. Staging Mobilities

    DEFF Research Database (Denmark)

    Jensen, Ole B.

    In recent years, the social sciences have taken a “mobilities turn.” There has been a developing realisation that mobilities do not “just happen.” Mobilities are carefully and meticulously designed, planned and staged (from above). However, they are equally importantly acted out, performed...... that mobility is more than movement between point A and B. It explores how the movement of people, goods, information, and signs influences human understandings of self, other and the built environment. Moving towards a new understanding of the relationship between movement, interaction and environments......, the book asks: what are the physical, social, technical, and cultural conditions to the staging of contemporary urban mobilities?...

  8. Outplacement as Transition Counseling. (United States)

    Mirabile, Richard J.


    Describes outplacement counseling as a process that enables management to deal with the problem of the employee who must be released or the staff that must be reduced. Discusses the process of outplacement counseling, the stages of transition counseling, and techniques to be implemented. (BH)

  9. Microwave measurements and beam dynamics simulations of the BNL/SLAC/UCLA emittance-compensated 1.6-cell photocathode rf gun (United States)

    Palmer, Dennis T.; Miller, Roger H.; Winick, Herman; Wang, Xi J.; Batchelor, Kenneth; Woodle, Martin H.; Ben-Zvi, Ilan


    A dedicated low energy (2 to 10 MeV) experimental beam line is now under construction at Brookhaven National Laboratory/Accelerator Test Facility (BNL/ATF) for photocathode RF gun testing and photoemission experiments. Microwave measurements of the 1.6 cell photocathode RF gun have been conducted along with beam dynamics simulations of the emittance compensated low energy beam. These simulations indicate that the 1.6 cell photocathode RF gun in combination with solenoidal emittance compensation will be capable of producing a high brightness beam with a normalization rms emittance of (epsilon) n,rms approximately equals 1 (pi) mm mrad. The longitudinal accelerating field Ez has been measured as a function of azimuthal angle in the full cell of the cold test model for the 1.6 cell BNL/SLAC/UCLA #3 S-band RF Gun using a needle rotation/frequency perturbation technique. These measurements were conducted before and after symmetrizing the full cell with a vacuum pump out port and an adjustable short. Two different waveguide to full cell coupling schemes were studied. Experimental and theoretical studies of the field balance versus mode separation were conducted. The dipole mode of the full cell using the (theta) - coupling scheme is an order of magnitude less severe before symmetrization than the Z- coupling scheme. The multi-pole contribution to the longitudinal field asymmetry are calculated using standard Fourier series techniques for both coupling schemes. The Panofsky- Wenzel theorem is used in estimating the transverse emittance due to the multipole components of Ez. Detailed beam dynamics simulations were performed for the 1.6 cell photocathode RF gun injector using a solenoidal emittance compensation technique. The design of the experimental line along with a proposed experimental program using the 1.6 cell photocathode RF gun developed by the BNL/SLAC/UCLA RF gun collaboration is presented. This experimental program includes measurements of beam loading caused by dark current, higher order mode field measurements, integrated and slice emittance measurements using a pepper-pot and RF kicker cavity.

  10. Single-Cell Mass Spectrometry for Discovery Proteomics: Quantifying Translational Cell Heterogeneity in the 16-Cell Frog (Xenopus) Embryo. (United States)

    Lombard-Banek, Camille; Moody, Sally A; Nemes, Peter


    We advance mass spectrometry from a cell population-averaging tool to one capable of quantifying the expression of diverse proteins in single embryonic cells. Our instrument combines capillary electrophoresis (CE), electrospray ionization, and a tribrid ultrahigh-resolution mass spectrometer (HRMS) to enable untargeted (discovery) proteomics with ca. 25 amol lower limit of detection. CE-μESI-HRMS enabled the identification of 500-800 nonredundant protein groups by measuring 20 ng, or frog (Xenopus laevis) embryo, amounting to a total of 1709 protein groups identified between n=3 biological replicates. By quantifying ≈150 nonredundant protein groups between all blastomeres and replicate measurements, we found significant translational cell heterogeneity along multiple axes of the embryo at this very early stage of development when the transcriptional program of the embryo has yet to begin.

  11. 产业结构转型期珠三角体育用品出口PEST分析%A PEST Analysis of Sports Goods Export of the Pearl River Delta in the Transition Stage of Industrial Structure

    Institute of Scientific and Technical Information of China (English)



    Using the methods of literature search and market surveys,and taking the PEST model as the basis,this paper analyzed the macro environment that sports goods export of the Pearl River Delta faces in the transition stage of industrial structure from political,economic,social and technical dimensions. Politically,the macro environment is characterized by,(1)the provision of national laws and policies;(2)favorable foreign trade policies in Guangdong;and(3)a lack of industry standardization. Economically,by(1)instability in international trade relations,with an co-existence of both risks and opportunities;(2)obvious negative influence of the RMB exchange rate(appreciation);(3)huge technological barriers and a high incidence of trade friction. Socially,by(1) rising labor costs and a re-versed social mobility;( 2 ) social trends and fashions favorable to domestic sports goods market;( 3 ) a domestic brand-friendly sports event marketing. Technologically,by(1) the initial formation of government policies and plat-forms for the R&D;(2)a shortage of the R&D of sports activities in small and medium-sized enterprises,and in-sufficient patent consciousness;(3)enterprise marketing reform given rise to by the“cloud” technology and network platform. Finally the article put forward five countermeasures:(1)taking advantage of the good policy environment, strengthening the industry standardization and internationalization of construction;( 2 ) proactively coping with trade barriers and trade friction;(3)being flexible when dealing with the problem of RMB exchange rate(appreciation);(4) building industry clusters with competitive enterprise R & D;( 5 ) promoting, standardizing and perfecting network marketing.%运用文献法与市场调研法,以PEST模型为依据,从政治、经济、社会以及技术4个维度分析产业结构转型期珠三角体育用品出口所面临的宏观环境。研究结果:(1)政治环境表现为:①国家法律与政策积极保障;

  12. Family Caregiver Palliative Care Intervention in Supporting Caregivers of Patients With Stage II-IV Gastrointestinal, Gynecologic, and Urologic Cancers (United States)


    Healthy, no Evidence of Disease; Localized Transitional Cell Cancer of the Renal Pelvis and Ureter; Metastatic Transitional Cell Cancer of the Renal Pelvis and Ureter; Psychosocial Effects of Cancer and Its Treatment; Recurrent Bladder Cancer; Recurrent Cervical Cancer; Recurrent Colon Cancer; Recurrent Gastric Cancer; Recurrent Ovarian Epithelial Cancer; Recurrent Ovarian Germ Cell Tumor; Recurrent Pancreatic Cancer; Recurrent Rectal Cancer; Recurrent Renal Cell Cancer; Recurrent Transitional Cell Cancer of the Renal Pelvis and Ureter; Recurrent Urethral Cancer; Recurrent Uterine Sarcoma; Regional Transitional Cell Cancer of the Renal Pelvis and Ureter; Stage II Bladder Cancer; Stage II Renal Cell Cancer; Stage II Urethral Cancer; Stage IIA Cervical Cancer; Stage IIA Colon Cancer; Stage IIA Gastric Cancer; Stage IIA Ovarian Epithelial Cancer; Stage IIA Ovarian Germ Cell Tumor; Stage IIA Pancreatic Cancer; Stage IIA Rectal Cancer; Stage IIA Uterine Sarcoma; Stage IIB Cervical Cancer; Stage IIB Colon Cancer; Stage IIB Gastric Cancer; Stage IIB Ovarian Epithelial Cancer; Stage IIB Ovarian Germ Cell Tumor; Stage IIB Pancreatic Cancer; Stage IIB Rectal Cancer; Stage IIB Uterine Sarcoma; Stage IIC Colon Cancer; Stage IIC Ovarian Epithelial Cancer; Stage IIC Ovarian Germ Cell Tumor; Stage IIC Rectal Cancer; Stage III Bladder Cancer; Stage III Pancreatic Cancer; Stage III Renal Cell Cancer; Stage III Urethral Cancer; Stage IIIA Cervical Cancer; Stage IIIA Colon Cancer; Stage IIIA Gastric Cancer; Stage IIIA Ovarian Epithelial Cancer; Stage IIIA Ovarian Germ Cell Tumor; Stage IIIA Rectal Cancer; Stage IIIA Uterine Sarcoma; Stage IIIB Cervical Cancer; Stage IIIB Colon Cancer; Stage IIIB Gastric Cancer; Stage IIIB Ovarian Epithelial Cancer; Stage IIIB Ovarian Germ Cell Tumor; Stage IIIB Rectal Cancer; Stage IIIB Uterine Sarcoma; Stage IIIC Colon Cancer; Stage IIIC Gastric Cancer; Stage IIIC Ovarian Epithelial Cancer; Stage IIIC Ovarian Germ Cell Tumor; Stage IIIC Rectal

  13. Sustainable Transition

    DEFF Research Database (Denmark)

    Hansen, Ole Erik; Søndergård, Bent


    transition processes. Where. Addresses design processes aimed at sustainable transition enacted in complex social settings, socio-technical systems involving many different actors and agendas. How. The chapter outlines a conceptual and analytic framework for a reflexive design practice for sustainability...... including the perspective of structural changes (transition of socio-technical systems and social practices) and Design as metadesign; an reflexivity on contextual framework of the design practice (regimes/design spaces)....

  14. Cervical Cancer Stage IVA (United States)

    ... historical Searches are case-insensitive Cervical Cancer Stage IVA Add to My Pictures View /Download : Small: 756x576 ... Large: 3150x2400 View Download Title: Cervical Cancer Stage IVA Description: Stage IVA cervical cancer; drawing and inset ...

  15. Study on the Strategic Transformation of Jinjiang's Private Firms in the Transitional Period:A Stage Model of Strategic Choice%转型期晋江私营企业的战略演变过程——一个战略选择的阶段模型

    Institute of Scientific and Technical Information of China (English)



    This paper analyzes the track of the development of Jinjiang private firms in the transitional period. The results show that there are two kinds of logic in their strategic choices, one is the pursuit of efficiency, the other is the pursuit of obeying the legitimacy. Their competitive strategies based on the pursuit of efficiency go through three stages, these are social capital strategy, overall cost leadership strategy and differentiation strategy. Their adaptation strategies based on the pursuit of obeying the legitimacy also go through three stages,these are social capital strategy, imitation strategy and quality strategies. Integrating task environment and institutional environment perspective, and combining with the basic theory of resources, this paper puts forward a stage model of strategic choice of private enterprise during the transitional period.%通过分析晋江私营企业在转型时期的战略演变过程,发现其战略选择存在着两种逻辑,即追求效率逻辑和服从合法性逻辑。追求效率的竞争战略经历了社会资本战略、低成本战略和差异化战略三个阶段的演变,服从合法性机制的适应战略经历了社会资本战略、模仿战略和质量战略三个阶段的演变。整合任务环境和制度环境观点,并结合资源基础理论提出一个转型时期私营企业战略选择的阶段模型。

  16. Between Stage and Screen

    NARCIS (Netherlands)

    Tornqvist, Egil


    Ingmar Bergman is worldwide known as a film and stage director. Yet no-one has attempted to compare his stage and screen activities. In Between stage and screen Egil Tornqvist examines formal and thematical correspondences and differences between a number of Bergman's stage, screen, and radio produc

  17. Phase transitions

    CERN Document Server

    Solé, Ricard V


    Phase transitions--changes between different states of organization in a complex system--have long helped to explain physics concepts, such as why water freezes into a solid or boils to become a gas. How might phase transitions shed light on important problems in biological and ecological complex systems? Exploring the origins and implications of sudden changes in nature and society, Phase Transitions examines different dynamical behaviors in a broad range of complex systems. Using a compelling set of examples, from gene networks and ant colonies to human language and the degradation o

  18. Developmental transitions: So what's new?

    NARCIS (Netherlands)

    van der Maas, H.L.J.; Hopkins, B.


    Structural approaches to development, such as Piaget's stage theory, have proved to be problematic in dealing with developmental transitions. More promising in this respect are models of qualitative change that address macroscopical phase shifts in non-linear dynamicalsystems that arise from quantit

  19. [16S rDNA diversity analysis of 30 Streptomycetes isolates displaying significant cytotoxic activity against B16 cell from near-shore sediments of Hainan Island]. (United States)

    Yan, Li-Ping; Hong, Kui; Hu, Shen-cai; Liu, Li-hua


    A total of 354 isolates of actinomycetes, of which 76 were detected cytotoxic activity was isolated from near-shore marine samples collected at Wenchang mangrove, DanZhou harbor and YanPu harbor. Four isolation methods were employed, which are SDS pretreatment, phenol pretreatment, heating pretreatment and potassium dichromate selection culture, and media such as'Yeast extract-Malt extract (YE), Glucose-Asprine (GA), Starch-Casin (SC), Starch-KNO3 (Gause) were used. It was showed that heating pretreatment and potassium dichromate selection culture were more considerable methods for extensive isolation of actinomycetes. Medium YE and Gause showed best results in both the total number of actinomycetes and the number of active isolates against tumor cell B16. The genotypic diversity of 30 strains of Streptomycetes possessing strong cytotoxic activity against B16 cell (ID50 > or =200) was analyzed by 16S ARDRA, which resulted in 17 RFLP types, and indicated relatively rich genotypic diversity among these Streptomycetes. 16S rDNA sequence analysis of three strains, 050642, 060386 and 060524 (ID50 > or = 1200) further confirmed that they all belong to Streptomyces genus and strain 050642 was suggested a novel Streptomyces. Spp with the highest similarity of 95% to Streptomyces cattleya.

  20. Cervical Cancer Stage IVB (United States)

    ... of the body, such as the lymph nodes, lung, liver, intestine, or bone. Stage IVB cervical cancer. Topics/Categories: Anatomy -- Gynecologic Cancer Types -- Cervical Cancer Staging Type: Color, ...

  1. Stages of Adolescence (United States)

    ... Español Text Size Email Print Share Stages of Adolescence Page Content Article Body Adolescence, these years from puberty to adulthood, may be roughly divided into three stages: early adolescence, generally ages eleven to fourteen; middle adolescence, ages ...

  2. Stages of Esophageal Cancer (United States)

    ... stage 0 , abnormal cells are found in the mucosa or submucosa layer of the esophagus wall. These ... found. Stage IA : Cancer has formed in the mucosa or submucosa layer of the esophagus wall. The ...

  3. Dynamic Stage Design

    Institute of Scientific and Technical Information of China (English)

    Florian von Hofen[GER


    Concepts and methods for dynamic stage designs were introduced ranging from different ifelds of TV live shows, exhibitions and theatre performances, and a special emphasis was put on solution to the theatre stage design.

  4. Ages and Stages: Teen (United States)

    ... Spread the Word Shop AAP Find a Pediatrician Ages & Stages Prenatal Baby Toddler Preschool Gradeschool Teen Dating & ... Safety School Substance Abuse Young Adult Healthy Children > Ages & Stages > Teen Teen Article Body Adolescence can be ...

  5. Breast cancer staging (United States)

    ... this page: // Breast cancer staging To use the sharing features on this ... Once your health care team knows you have breast cancer , they will do more tests to stage it. ...

  6. Beyond Erikson's Eight Stages. (United States)

    Whitney, Ruth


    Erik Erikson has described eight stages of the healthy personality. This essay offers a revised version of the eight stages. Although most individuals develop through the eight stages, each is personally unique because patterns of fluctuation between safety and growth differ from one individual to another. (Author)

  7. Ovarian Cancer Stage II (United States)

    ... hyphen, e.g. -historical Searches are case-insensitive Ovarian Cancer Stage II Add to My Pictures View /Download : ... 1650x675 View Download Large: 3300x1350 View Download Title: Ovarian Cancer Stage II Description: Three-panel drawing of stage ...

  8. Ovarian Cancer Stage IIIC (United States)

    ... hyphen, e.g. -historical Searches are case-insensitive Ovarian Cancer Stage IIIC Add to My Pictures View /Download : ... 1530x1350 View Download Large: 3060x2700 View Download Title: Ovarian Cancer Stage IIIC Description: Drawing of stage IIIC shows ...

  9. Ovarian Cancer Stage I (United States)

    ... hyphen, e.g. -historical Searches are case-insensitive Ovarian Cancer Stage I Add to My Pictures View /Download : ... 1650x675 View Download Large: 3300x1350 View Download Title: Ovarian Cancer Stage I Description: Three-panel drawing of stage ...

  10. Unsteady Interaction Between a Transonic Turbine Stage and Downstream Components


    Davis Roger; Yao Jixian; Clark John; Stetson Gary; Alonso Juan; Jameson Antony; Haldeman Charles; Dunn Michael


    Results from a numerical simulation of the unsteady flow through one quarter of the circumference of a transonic high-pressure turbine stage, transition duct, and low-pressure turbine first vane are presented and compared with experimental data. Analysis of the unsteady pressure field resulting from the simulation shows the effects of not only the rotor/stator interaction of the high-pressure turbine stage but also new details of the interaction between the blade and the downstream transition...

  11. Cosmological phase transitions from lattice field theory

    Energy Technology Data Exchange (ETDEWEB)

    Jansen, Karl [Deutsches Elektronen-Synchrotron (DESY), Zeuthen (Germany). John von Neumann-Inst. fuer Computing NIC


    In this proceedings contribution we discuss the fate of the electroweak and the quantum chromodynamics phase transitions relevant for the early stage of the universe at non-zero temperature. These phase transitions are related to the Higgs mechanism and the breaking of chiral symmetry, respectively. We will review that non-perturbative lattice field theory simulations show that these phase transitions actually do not occur in nature and that physical observables show a completely smooth behaviour as a function of the temperature.

  12. Second stage of labor. (United States)

    Cheng, Yvonne W; Caughey, Aaron B


    Current American College of Obstetricians and Gynecologists' definition of prolonged second stage diagnoses 10% to 14% of nulliparous and 3% to 3.5% of multiparous women as having a prolonged second stage. The progression of labor in modern obstetrics may have deviated from the current labor norms established in the 1950s, likely due to differences in obstetric population characteristics and variation in clinical practice. Optimal management of the second stage in women with and without epidural remains debatable. Although prolonged second stage is associated with increased risk of maternal morbidity, conflicting data exist regarding the duration of second stage and associated neonatal morbidity and mortality.

  13. Observing river stages using unmanned aerial vehicles (United States)

    Niedzielski, Tomasz; Witek, Matylda; Spallek, Waldemar


    We elaborated a new method for observing water surface areas and river stages using unmanned aerial vehicles (UAVs). It is based on processing multitemporal five orthophotomaps produced from the UAV-taken visible light images of nine sites of the river, acquired with a sufficient overlap in each part. Water surface areas are calculated in the first place, and subsequently expressed as fractions of total areas of water-covered terrain at a given site of the river recorded on five dates. The logarithms of the fractions are later calculated, producing five samples, each consisted of nine elements. In order to detect statistically significant increments of water surface areas between two orthophotomaps, we apply the asymptotic and bootstrapped versions of the Student's t test, preceded by other tests that aim to check model assumptions. The procedure is applied to five orthophotomaps covering nine sites of the Ścinawka river (south-western (SW) Poland). The data have been acquired during the experimental campaign, at which flight settings were kept unchanged over nearly 3 years (2012-2014). We have found that it is possible to detect transitions between water surface areas associated with all characteristic water levels (low, mean, intermediate and high stages). In addition, we infer that the identified transitions hold for characteristic river stages as well. In the experiment we detected all increments of water level: (1) from low stages to mean, intermediate and high stages; (2) from mean stages to intermediate and high stages; and (3) from intermediate stages to high stages. Potential applications of the elaborated method include verification of hydrodynamic models and the associated predictions of high flows as well as monitoring water levels of rivers in ungauged basins.

  14. Tessellations & Transitions. (United States)

    Cassidy, Joan


    Describes two sixth-grade lessons on the work of M. C. Escher: (1) the first lesson instructs students on tessellations, or tiles that interlock in a repeated pattern; (2) the second lesson explores Escher's drawings of transitions from two- to three-dimensional space. (DSK)

  15. Cetuximab, Cisplatin, and Radiation Therapy in Treating Patients With Stage IB, Stage II, Stage III, or Stage IVA Cervical Cancer (United States)


    Cervical Adenocarcinoma; Cervical Adenosquamous Carcinoma; Cervical Small Cell Carcinoma; Cervical Squamous Cell Carcinoma; Stage IB Cervical Cancer; Stage IIA Cervical Cancer; Stage IIB Cervical Cancer; Stage III Cervical Cancer; Stage IVA Cervical Cancer

  16. Staged electrostatic precipitator (United States)

    Miller, Stanley J.; Almlie, Jay C.; Zhuang, Ye


    A device includes a chamber having an air inlet and an air outlet. The device includes a plurality of stages including at least a first stage adjacent a second stage. The plurality of stages are disposed in the chamber and each stage has a plurality of discharge electrodes disposed in an interior region and is bounded by an upstream baffle on an end proximate the air inlet and bounded by a downstream baffle on an end proximate the air outlet. Each stage has at least one sidewall between the upstream baffle and the downstream baffle. The sidewall is configured as a collection electrode and has a plurality of apertures disposed along a length between the upstream baffle and the downstream baffle. The upstream baffle of the first stage is positioned in staggered alignment relative to the upstream baffle of the second stage and the downstream baffle of the first stage are positioned in staggered alignment relative to the downstream baffle of the second stage.

  17. Staging Mobilities / Designing Mobilities

    DEFF Research Database (Denmark)

    Jensen, Ole B.


    In recent years, urban research has taken a ‘mobilities turn’. There has been a developing realisation that mobilities do not ‘just happen.’ Mobilities are carefully and meticulously designed, planned and staged (from above). However, they are equally importantly acted out, performed and lived...... as people are ‘staging themselves’ (from below). Staging mobilities is a dynamic process between ‘being staged’ (for example, being stopped at traffic lights) and the ‘mobile staging’ of interacting individuals (negotiating a passage on the pavement). Staging mobilities is about the fact that mobility...... asks: what are the physical, social, technical, and cultural conditions to the staging of contemporary urban mobilities? The theoretical framing in the Staging mobilities book is applied to four in-depth cases in the accompanying volume Designing mobilities.This book explore how places, sites...

  18. Transition Operators

    CERN Document Server

    Alcock-Zeilinger, Judith


    In this paper, we give a generic algorithm of the transition operators between Hermitian Young projection operators corresponding to equivalent irreducible representations of SU(N), using the compact expressions of Hermitian Young projection operators derived in a companion paper. We show that the Hermitian Young projection operators together with their transition operators constitute a fully orthogonal basis for the algebra of invariants of $V^{\\otimes m}$ that exhibits a systematically simplified multiplication table. We discuss the full algebra of invariants over $V^{\\otimes 3}$ and $V^{\\otimes 4}$ as explicit examples. In our presentation we make use of various standard concepts such as Young projection operators, Clebsch-Gordan operators, and invariants (in birdtrack notation). We tie these perspectives together and use them to shed light on each other.

  19. Epidemiological Transition of End-Stage Kidney Disease in Oman

    Directory of Open Access Journals (Sweden)

    Faisal Al Ismaili


    Discussion: The incidence and prevalence of ESKD has increased progressively over last 30 years. This is anticipated to continue at an even higher rate in view of the progressive rise in noncommunicable diseases. Continuous improvement in registries is required to improve capturing of ESKD patients for providing accurate data to health authorities, and enhancing public awareness of the magnitude, future trends, treatments, and outcomes regarding ESKD.

  20. Exploring the transition from registered nurse to family nurse practitioner. (United States)

    Poronsky, Cathlin Buckingham


    There is limited information available regarding the transition from registered nurse (RN) to family nurse practitioner (FNP). Several authors described this transition as taking place in 4 stages, and others described it as a 2-phase process. However, there is a lack of consensus about the definition of these stages and phases and at what point they occur for nurses who are making the transition from an RN to an FNP. From what is known, this multistage/2-phase transition is accompanied by feelings of anxiety, stress, role confusion, and emotional turmoil. As a nurse faculty member, the author theorized that nurse faculty might be in a position to provide support for graduate students making this transition in role. However, there was little information available about the transition phases, stages, and needs of students during graduate school. The search for a framework to explore transition yielded transition theory, which is described and applied to FNP transition in this article. Transition theory may be useful for examining more fully the phases and stages of RN-to-FNP transition. In this time of increased need for qualified primary care providers, it is essential that graduates of FNP programs transition into practice following graduation.

  1. Multiple Stages 2

    DEFF Research Database (Denmark)

    Andreasen, John

    Multiple stages 2: theatrical futures, set design, community plays, cultural capitals, democracy & drama, WWII dramas, performance on adoption, promenade about emigration, qualities in political theatre, performance analysis, dramaturgical education, Toulmin Variations......Multiple stages 2: theatrical futures, set design, community plays, cultural capitals, democracy & drama, WWII dramas, performance on adoption, promenade about emigration, qualities in political theatre, performance analysis, dramaturgical education, Toulmin Variations...

  2. Neutron interferometry with cold stage (United States)

    Mineeva, Taisiya; Arif, M.; Huber, M. G.; Shahi, C. B.; Clark, C. W.; Cory, D. G.; Nsofini, J.; Sarenac, D.; Pushin, D. A.

    Neutron interferometry (NI) is amongst the most precise methods for characterizing neutron interactions by measuring the relative difference between two neutron paths, one of which contains a sample-of-interest. Because neutrons carry magnetic moment and are deeply penetrating, they are excellent probes to investigate properties of magnetic materials. The advantage of NI is its unique sensitivity which allows to directly measure magnetic and structural transitions in materials. Up to now NI has been sparingly used in material research due to its sensitivity to environmental noise. However, recent successes in implementing Quantum Error Correction principles lead to an improved NI design making it robust against mechanical vibrations. Following these advances, a new user facility at the National Institute for Standards and Technology was built to study condensed matter applications, biology and quantum physics. Incorporating cold sample stage inside NI is the first of its kind experiment which can be carried out on large range of temperatures down to 4K. Upon successful realization, it will open new frontiers to characterize magnetic domains, phase transitions and spin properties in a variety of materials such as, for example, iron-based superconductors and spintronic materials. Supported in part by CERC, CIFAR, NSERC and CREATE.

  3. Transit space

    DEFF Research Database (Denmark)

    Raahauge, Kirsten Marie


    This article deals with representations of one specific city, Århus, Denmark, especially its central district. The analysis is based on anthropological fieldwork conducted in Skåde Bakker and Fedet, two well-off neighborhoods. The overall purpose of the project is to study perceptions of space...... and the interaction of cultural, social, and spatial organizations, as seen from the point of view of people living in Skåde Bakker and Fedet. The focus is on the city dwellers’ representations of the central district of Århus with specific reference to the concept of transit space. When applied to various Århusian...

  4. Conformational Transitions (United States)

    Czerminski, Ryszard; Roitberg, Adrian; Choi, Chyung; Ulitsky, Alexander; Elber, Ron


    Two computational approaches to study plausible conformations of biological molecules and the transitions between them are presented and discussed. The first approach is a new search algorithm which enhances the sampling of alternative conformers using a mean field approximation. It is argued and demonstrated that the mean field approximation has a small effect on the location of the minima. The method is a combination of the LES protocol (Locally Enhanced Sampling) and simulated annealing. The LES method was used in the past to study the diffusion pathways of ligands from buried active sites in myoglobin and leghemoglobin to the exterior of the protein. The present formulation of LES and its implementation in a Molecular Dynamics program is described. An application for side chain placement in a tetrapeptide is presented. The computational effort associated with conformational searches using LES grows only linearly with the number of degrees of freedom, whereas in the exact case the computational effort grows exponentially. Such saving is of course associated with a mean field approximation. The second branch of studies pertains to the calculation of reaction paths in large and flexible biological systems. An extensive mapping of minima and barriers for two different tetrapeptides is calculated from the known minima and barriers of alanine tetrapeptide which we calculated recently.1 The tetrapeptides are useful models for the formation of secondary structure elements since they are the shortest possible polymers of this type which can still form a complete helical turn. The tetrapeptides are isobutyryl-val(χ1=60)-ala-ala and isobutyryl-val(χ1=-60)-ala-ala. Properties of the hundreds of minima and of the hundreds intervening barriers are discussed. Estimates for thermal transition times between the many conformers (and times to explore the complete phase space) are calculated and compared. It is suggested that the most significant effect of the side chain size is

  5. Long-transition analysis for post shot-boundary detection (United States)

    Heng, Wei J.; Ngan, King N.


    With the introduction of the standard in video indexing, research in shot boundary detection has recently become popular. While new solutions for long transition detection have recently emerged, there is not much literature that focuses on what to do with the frames within the transition when they are detected. After the approximate position of the long transition is detected, the raw sequence cannot be used for segmentation and indexing due to the special effects incorporated. Here, a technique aims at extracting extra information from the transition after the existence of a long transition is confirmed. This technique consists of four stages, namely, shot boundary refinement, shot type determination, frame reconstruction for soft transition and pixel classification for hard transition. This paper gives the overview as well as performance of each stage. This technique allows detected transitions to be analyzed without human intervention.

  6. Stages of Gallbladder Cancer (United States)

    ... cancer. Tests that examine the gallbladder and nearby organs are used to detect (find), diagnose, and stage ... cancer cells or to make cancer cells more sensitive to the effects of radiation therapy and certain ...

  7. Thyroid Cancer Staging

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Ja Young; Kim, Soo Jin; Kim, Eun Kyung; Kwak, Jin Young [Yonsei University College of Medicine, Seoul (Korea, Republic of)


    The current prevalence of thyroid cancer in women is high. Likewise, other cancers and thyroid cancer have been based on the TNM classification system. Staging of thyroid cancer has an important role in determining the extent of surgical excision and lymph node dissection, planning the adjuvant therapy after surgery and predicting the recurrence rate and the prognosis of patients. Ultrasonography is the basic imaging modality to identify the tumor size and the extent of lymph node metastasis. More recently, computed tomography, magnetic resonance imaging and positron emission tomography provide additional help for the staging of thyroid cancer. So, this article describes the 7th edition of the TNM staging of thyroid cancer, as proposed by the American Joint Committee on Cancer, and the details of radiologic evaluation of the T, N and M stages

  8. Late-Stage Caregiving (United States)

    ... resources, care and ways to engage in meaningful connections. During the late stages, your role as a ... drinks. This will help you track the person's natural routine, and then you can plan a schedule. ...

  9. Understanding cancer staging (United States)

    ... Manual and Handbook . 2nd ed. New York, NY: Springer; 2012. National Cancer Institute. Staging. Updated March 9, ... medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only -- ...

  10. Staged bilateral carotid endarterectomy

    DEFF Research Database (Denmark)

    Schroeder, T; Sillesen, H; Engell, Hans Christian


    In a series of 56 staged bilateral carotid endarterectomies, new neurologic symptoms developed in 5% and 20% following the first and second procedure, respectively. All complications were transient or minor. The incidence of postendarterectomy hypertension was significantly higher following...

  11. The Transition to Secondary Progressive Multiple Sclerosis (United States)

    Wood, Fiona; Brain, Katherine E.; Edwards, Michelle; Jones, Rhiannon; Wallbank, Rachel; Robertson, Neil P.; Edwards, Adrian


    Background: Identifying the transition from relapsing-remitting to secondary progressive multiple sclerosis (SPMS) can be challenging for clinicians. Little previous research has explored how professionals experience working with patients during this specific stage of the disease. We explored the experiences of a group of multidisciplinary professionals who support patients in the transition to SPMS to describe this stage from a professional perspective. Methods: This qualitative semistructured interview study included 11 professionals (medical, nursing, and allied health professionals; specialists and generalists) working with patients with MS in South Wales, United Kingdom. Thematic analysis of the interview data was performed. Results: Two overarching themes were identified: the transition and providing support. The transition theme comprised issues related to recognizing and communicating about SPMS. Uncertainty influenced recognizing the transition and knowing how to discuss it with patients. The providing support theme included descriptions of challenging aspects of patient care, providing support for caregivers, using the multidisciplinary team, and working within service constraints. Providing adequate psychological support and engaging patients with self-management approaches were seen as particularly challenging. Conclusions: Caring for patients in the transition to SPMS generates specific challenges for professionals. Further research on health-care interactions and patients'/professionals' experiences regarding the transition phase may help identify strategies for professional development and learning and how to optimize the patient experience at this difficult stage of disease. PMID:27803641

  12. Optical control of multi-stage thin film solar cell production

    Energy Technology Data Exchange (ETDEWEB)

    Li, Jian; Levi, Dean H.; Contreras, Miguel A.; Scharf, John


    Embodiments include methods of depositing and controlling the deposition of a film in multiple stages. The disclosed deposition and deposition control methods include the optical monitoring of a deposition matrix to determine a time when at least one transition point occurs. In certain embodiments, the transition point or transition points are a stoichiometry point. Methods may also include controlling the length of time in which material is deposited during a deposition stage or controlling the amount of the first, second or subsequent materials deposited during any deposition stage in response to a determination of the time when a selected transition point occurs.

  13. Normalization: A Preprocessing Stage


    Patro, S. Gopal Krishna; Sahu, Kishore Kumar


    As we know that the normalization is a pre-processing stage of any type problem statement. Especially normalization takes important role in the field of soft computing, cloud computing etc. for manipulation of data like scale down or scale up the range of data before it becomes used for further stage. There are so many normalization techniques are there namely Min-Max normalization, Z-score normalization and Decimal scaling normalization. So by referring these normalization techniques we are ...

  14. Bioimpedance Spectroscopy in Detecting Lower-Extremity Lymphedema in Patients With Stage I, Stage II, Stage III, or Stage IV Vulvar Cancer Undergoing Surgery and Lymphadenectomy (United States)


    Lymphedema; Perioperative/Postoperative Complications; Stage IA Vulvar Cancer; Stage IB Vulvar Cancer; Stage II Vulvar Cancer; Stage IIIA Vulvar Cancer; Stage IIIB Vulvar Cancer; Stage IIIC Vulvar Cancer; Stage IVA Vulvar Cancer; Stage IVB Vulvar Cancer

  15. Political symbols and political transitions

    Directory of Open Access Journals (Sweden)

    Herrero de Miñón, Miguel


    Full Text Available Politics, Law and Psychology are fields that come together in the symbolic. This text takes evidence from those three areas to develop an analysis of political symbols and political transitions. The development of the analysis goes through three stages. The first succinctly describes the concept of transition and its meaning. The second closely examines the notion of the symbol, in terms of its definition, to explain aspects that allow us to understand it, characterise it and make its functions clear. Finally, from the author's experience as a witness and as an actor, I suggest three ways of understanding symbols in the processes of political transition: as symbols of change, as symbols of acknowledgment, and as symbols of support.

  16. Chemotherapy Toxicity On Quality of Life in Older Patients With Stage I, Stage II, Stage III, or Stage IV Ovarian Epithelial, Primary Peritoneal Cavity, or Fallopian Tube Cancer (United States)


    Stage I Ovarian Cancer; Stage IA Fallopian Tube Cancer; Stage IB Fallopian Tube Cancer; Stage IC Fallopian Tube Cancer; Stage II Ovarian Cancer; Stage IIA Fallopian Tube Cancer; Stage IIB Fallopian Tube Cancer; Stage IIC Fallopian Tube Cancer; Stage III Ovarian Cancer; Stage III Primary Peritoneal Cancer; Stage IIIA Fallopian Tube Cancer; Stage IIIB Fallopian Tube Cancer; Stage IIIC Fallopian Tube Cancer; Stage IV Fallopian Tube Cancer; Stage IV Ovarian Cancer; Stage IV Primary Peritoneal Cancer

  17. Composers on stage

    DEFF Research Database (Denmark)

    Groth, Sanne Krogh

    A trend on the scene of contemporary music is composers going on stage, performing their pieces themselves. Within a discourse of popular music, this is more the rule than exception, but when it comes to the context of contemporary scored music, the historical and aesthetic context differs......, and something quite different is undergoing. This paper intends to discuss three examples of performances in which the composer’s appearance on stage was an important part of the piece, - both when it came to the role as a performer and as an individual person – as representer and presenter. The paper intends...... 2011 and Fischer-Lichte 2008) Hereby, the role of the composer appearing on stage is discussed from an aesthetic point of view; meanwhile social and political aspects of the phenomenon are also addressed. The three artistic works discussed are Simon Steen-Andersen’s Run Time Error (2009-), Niels...

  18. Transition towards Circular Economy in the Food System

    Directory of Open Access Journals (Sweden)

    Alexandra Jurgilevich


    Full Text Available Growing population and increased demand for food, inefficient resource use and food distribution, environmental impacts, and high rates of food wasted at all stages of the food system are all calling for transition towards more sustainable practices. In this article we apply the concept of circular economy to the case of a sustainable food system. Furthermore, we explore the transition towards a circular food system through the lens of socio-technical transition theory towards sustainability. We discuss challenges and potential solutions for the production stage (focusing on nutrient flow, the consumption stage (focusing on meat consumption, and food waste and surplus management and prevention.

  19. Flow transition within an evaporating binary mixture sessile drop. (United States)

    Christy, John R E; Hamamoto, Yoshinori; Sefiane, Khellil


    The flow field along the base of an evaporating ethanol-water droplet and its evolution time was measured by particle image velocimetry. Three stages are revealed, a first stage dominated by multiple vortices, a second transition stage characterized by a remarkable spike in outward flow not previously identified, and a third stage dominated by outward flow identical to that found for pure water. Stage I is thought to be driven by surface tension gradients arising from local concentration variation. The spike in outward flow is explained in terms of a transition corresponding to almost total depletion of ethanol. An exponential decay in vorticity during the transition stage is explained in terms of ethanol diffusion from the bulk to the interface. We speculate on the existence of a zero-concentration wave propagating from the apex to the contact line corresponding to the final total depletion of ethanol.

  20. Staging of prostate cancer. (United States)

    Cheng, Liang; Montironi, Rodolfo; Bostwick, David G; Lopez-Beltran, Antonio; Berney, Daniel M


    Prostatic carcinoma (PCa) is a significant cause of cancer morbidity and mortality worldwide. Accurate staging is critical for prognosis assessment and treatment planning for PCa. Despite the large volume of clinical activity and research, the challenge to define the most appropriate and clinically relevant staging system remains. The pathologically complex and uncertain clinical course of prostate cancer further complicates the design of staging classification and a substaging system suitable for individualized care. This review will focus on recent progress and controversial issues related to prostate cancer staging. The 2010 revision of the American Joint Committee on Cancer/Union Internationale Contre le Cancer (AJCC/UICC) tumour, node and metastasis (TNM) system is the most widely used staging system at this time. Despite general acceptance of the system as a whole, there is controversy and uncertainty about its application, particularly for T2 subclassification. The three-tiered T2 classification system for organ-confined prostate cancer is superfluous, considering the biology and anatomy of PCa. A tumour size-based substaging system may be considered in the future TNM subclassification of pT2 cancer. Lymph node status is one of the most important prognostic factors for prostate cancer. Nevertheless, clinical outcomes in patients with positive lymph nodes are variable. Identification of patients at the greatest risk of systemic progression helps in the selection of appropriate therapy. The data suggest that the inherent aggressiveness of metastatic prostate cancer is closely linked to the tumour volume of lymph node metastasis. We recommend that a future TNM staging system should consider subclassification of node-positive cancer on the basis of nodal cancer volume, using the diameter of the largest nodal metastasis and/or the number of positive nodes.

  1. Biological differences that distinguish the two major stages of wound healing in potato tubers (United States)

    The two stages of wound healing have critical biological differences. The first stage, closing layer formation (CLF), involves early induction of DNA synthesis and nuclear division in the absence of cell division. The transition phase from CLF to the second stage is marked by a transient decrease in...

  2. How Is Ovarian Cancer Staged? (United States)

    ... Cancer Early Detection, Diagnosis, and Staging How Is Ovarian Cancer Staged? Staging is the process of finding out ... Ask Your Doctor About Ovarian Cancer? More In Ovarian Cancer About Ovarian Cancer Causes, Risk Factors, and Prevention ...

  3. Immunopathological patterns from EAE and Theiler's virus infection: Is multiple sclerosis a homogenous 1-stage or heterogenous 2-stage disease? (United States)

    Martinez, Nicholas E; Sato, Fumitaka; Omura, Seiichi; Minagar, Alireza; Alexander, J Steven; Tsunoda, Ikuo


    Multiple sclerosis (MS) is a disease which can presents in different clinical courses. The most common form of MS is the relapsing-remitting (RR) course, which in many cases evolves into secondary progressive (SP) disease. Autoimmune models such as experimental autoimmune encephalomyelitis (EAE) have been developed to represent the various clinical forms of MS. These models along with clinico-pathological evidence obtained from MS patients have allowed us to propose '1-stage' and '2-stage' disease theories to explain the transition in the clinical course of MS from RR to SP. Relapses in MS are associated with pro-inflammatory T helper (Th) 1/Th17 immune responses, while remissions are associated with anti-inflammatory Th2/regulatory T (Treg) immune responses. Based on the '1-stage disease' theory, the transition from RR to SP disease occurs when the inflammatory immune response overwhelms the anti-inflammatory immune response. The '2-stage disease' theory proposes that the transition from RR to SP-MS occurs when the Th2 response or some other responses overwhelm the inflammatory response resulting in the sustained production of anti-myelin antibodies, which cause continuing demyelination, neurodegeneration, and axonal loss. The Theiler's virus model is also a 2-stage disease, where axonal degeneration precedes demyelination during the first stage, followed by inflammatory demyelination during the second stage.

  4. Staging of Lung Cancer (United States)

    ... is important for two reasons. First, staging your lung cancer helps decide which therapy (or therapies) should be used. Second, lung cancer ... 422-6237 small-cell-lung/Patient/page2 National Lung ...

  5. Stages of Hypopharyngeal Cancer (United States)

    ... not spread to the larynx (voice box); or cancer has spread to the larynx or esophagus and is more than 4 centimeters; ... a common treatment for all stages of hypopharyngeal cancer. The following surgical ... to remove the larynx (voice box) and part of the pharynx (throat). ...

  6. World Stage Design

    Index Scriptorium Estoniae


    12-19. III Torontos rahvusvaheline lavakujunduse, kostüümi ning valgus- ja helikujunduse näitus, mis toimub samaaegselt OISTATi (International Organization of Scenographers, Theatre Architects and Technicians) maailmakongressiga ja USITT (United States Institute for Theatre Technology) üritustega (konverents, Stage Expo). Eestit esindab lavakujunduse kategoorias Lilja Blumenfeld-Luhse

  7. Implicit stage topics

    Directory of Open Access Journals (Sweden)

    Karen Lahousse


    Full Text Available Il a souvent été proposé que les éléments spatio-temporels en position initiale de phrase spécifient le cadre de l’événement dénoté par la proposition et ont une interprétation thématique ou topicale. Alors que les topiques spatio-temporels explicites ont souvent été étudiés, Erteschik-Schir (1997, 1999 propose l’idée que les topiques spatio-temporels, ou topiques scéniques (stage topics peuvent aussi être implicites.Dans cet article, nous offrons des arguments en faveur de la notion de topique scénique implicite. Nous montrons qu’un certain nombre de cas d’inversion nominale en français, une configuration syntaxique qui est favorisée par la présence d’un topique scénique explicite, s’expliquent par la présence d’un topique scénique implicite. Le fait que les topiques scéniques implicites interagissent avec la structure syntaxique de la même façon que les topiques scéniques explicites constitue un argument empirique en faveur de leur existence.It has often been proposed that sentence-initial spatio-temporal elements specify the frame in which the whole proposition takes place and are topical (i.e. thematic. Whereas considerable attention has been paid to explicit spatio-temporal topics, Erteschik-Shir (1997, 1999 argues that spatio-temporal topics, or stage topics, can also be implicit.In this article we provide evidence in favour of the notion of implicit stage topic. We show that a certain number of nominal inversion cases in French, a syntactic configuration which is triggered by the presence of an explicit stage topic, are explained by the presence of an implicit stage topic. The fact that implicit stage topics interact with syntactic structure the same way explicit stage topics do constitutes a strong empirical argument in favour of their existence.

  8. Multi-stage cleaning plant

    Energy Technology Data Exchange (ETDEWEB)

    Kullendorff, A.; Wikner, J.


    A cleaning plant positioned within an annular fluidized bed combustion chamber is divided into a plurality of separate cleaning stages, wherein a first stage is located adjacent the fluidized bed and additional stages are arranged within the first stage. Each stage comprises a plurality of separate cleaning devices which act in parallel, while cleaning devices of different stages act in series to remove debris from the combustion gases that exit from the fluidized bed combustion chamber.

  9. Metropolitanization:China’s Transitioning Urbanization Patterns

    Institute of Scientific and Technical Information of China (English)


    Amid larger institutional transitions,China has seen rapid urbanization stimulated by the marketization and new industrialization in the country.Now facing a series of new challenges,the traditional mode of urbanization needs to be changed.History has proven that metropolitanization is a necessary stage of urban development;under the circumstances of China’s current industrialization,metropolitanization emerges as the primary direction in China’s transitioning urbanization.This paper suggests certain measures for boosting metropolitanization and urbanization transition in China.

  10. Habitat Fragmentation Drives Plant Community Assembly Processes across Life Stages (United States)

    Hu, Guang; Feeley, Kenneth J.; Yu, Mingjian


    Habitat fragmentation is one of the principal causes of biodiversity loss and hence understanding its impacts on community assembly and disassembly is an important topic in ecology. We studied the relationships between fragmentation and community assembly processes in the land-bridge island system of Thousand Island Lake in East China. We focused on the changes in species diversity and phylogenetic diversity that occurred between life stages of woody plants growing on these islands. The observed diversities were compared with the expected diversities from random null models to characterize assembly processes. Regression tree analysis was used to illustrate the relationships between island attributes and community assembly processes. We found that different assembly processes predominate in the seedlings-to-saplings life-stage transition (SS) vs. the saplings-to-trees transition (ST). Island area was the main attribute driving the assembly process in SS. In ST, island isolation was more important. Within a fragmented landscape, the factors driving community assembly processes were found to differ between life stage transitions. Environmental filtering had a strong effect on the seedlings-to-saplings life-stage transition. Habitat isolation and dispersal limitation influenced all plant life stages, but had a weaker effect on communities than area. These findings add to our understanding of the processes driving community assembly and species coexistence in the context of pervasive and widespread habitat loss and fragmentation. PMID:27427960

  11. Stages: A system for generating strategic alternaties for forest management.


    Bos, J.


    Strategic planning is important in forest management. However, it has never been described clearly in literature. In this study a framework for strategic planning was developed and based on this a STrategic Alternatives Generating System (STAGES) to support decision making in strategic planning for forest management. This strategic planning consists of deciding on zoning, future forest and transition management. STAGES consists of a zoning model (which addresses the zoning decision problem th...

  12. Staging Sociotechnical Spaces

    DEFF Research Database (Denmark)

    Clausen, Christian; Yoshinaka, Yutaka


    The management of innovation and product development is increasingly facing complex challenges of staging design processes across heterogeneous organisational spaces, with multiple actor-concerns and sources of knowledge. This paper addresses how insights from the Actor-Network Theory and political...... process theory may contribute to a reflexive understanding of design as the staging of socio-technical relations and processes cutting across boundaries of diverse organisational, political and knowledge domains. This idea is pursued through the notion of ‘socio-technical spaces’. Socio-technical space...... of product development. The concept of socio-technical spaces is further illustrated through actual examples from industry dealing with early conceptualisation in product development and the role played by management concepts in the configuration of spaces....

  13. Calibration of Nanopositioning Stages

    Directory of Open Access Journals (Sweden)

    Ning Tan


    Full Text Available Accuracy is one of the most important criteria for the performance evaluation of micro- and nanorobots or systems. Nanopositioning stages are used to achieve the high positioning resolution and accuracy for a wide and growing scope of applications. However, their positioning accuracy and repeatability are not well known and difficult to guarantee, which induces many drawbacks for many applications. For example, in the mechanical characterisation of biological samples, it is difficult to perform several cycles in a repeatable way so as not to induce negative influences on the study. It also prevents one from controlling accurately a tool with respect to a sample without adding additional sensors for closed loop control. This paper aims at quantifying the positioning repeatability and accuracy based on the ISO 9283:1998 standard, and analyzing factors influencing positioning accuracy onto a case study of 1-DoF (Degree-of-Freedom nanopositioning stage. The influence of thermal drift is notably quantified. Performances improvement of the nanopositioning stage are then investigated through robot calibration (i.e., open-loop approach. Two models (static and adaptive models are proposed to compensate for both geometric errors and thermal drift. Validation experiments are conducted over a long period (several days showing that the accuracy of the stage is improved from typical micrometer range to 400 nm using the static model and even down to 100 nm using the adaptive model. In addition, we extend the 1-DoF calibration to multi-DoF with a case study of a 2-DoF nanopositioning robot. Results demonstrate that the model efficiently improved the 2D accuracy from 1400 nm to 200 nm.

  14. PyTransit: Transit light curve modeling (United States)

    Parviainen, Hannu


    PyTransit implements optimized versions of the Giménez and Mandel & Agol transit models for exoplanet transit light-curves. The two models are implemented natively in Fortran with OpenMP parallelization, and are accessed by an object-oriented python interface. PyTransit facilitates the analysis of photometric time series of exoplanet transits consisting of hundreds of thousands of data points, and of multipassband transit light curves from spectrophotometric observations. It offers efficient model evaluation for multicolour observations and transmission spectroscopy, built-in supersampling to account for extended exposure times, and routines to calculate the projected planet-to-star distance for circular and eccentric orbits, transit durations, and more.

  15. Characterization and endocytic internalization of Epith-2 cell surface glycoprotein during the epithelial-to-mesenchymal transition in sea urchin embryos

    Directory of Open Access Journals (Sweden)

    Norio eWakayama


    Full Text Available The epithelial cells of the sea urchin Hemicentrotus pulcherrimus embryo express an Epith-2, uncharacterized glycoprotein, on the lateral surface. Here, we describe internalization of Epith-2 during mesenchyme formation through the epithelial-to-mesenchymal transition (EMT. Epith-2 was first expressed on the entire egg surface soon after fertilization and on the blastomeres until the 4-cell stage, but was localized to the lateral surface of epithelial cells at and after the 16-cell stage throughout the later developmental period. However, primary (PMC and secondary mesenchyme cells (SMC that ingress by EMT lost Epith-2 from their cell surface by endocytosis during dissociation from the epithelium, which was associated with the appearance of cytoplasmic Epith-2 dots. The cytoplasmic Epith-2 retained a similar relative molecular mass to that of the cell surface immediately after ingression through the early period of the spreading to single cells. Then, Epith-2 was completely lost from the cytoplasm. Tyrosine residues of Epith-2 were phosphorylated. The endocytic retraction of Epith-2 was inhibited by herbimycin A (HA, a protein tyrosine kinase (PTK inhibitor, and suramin, a growth factor receptor (GFR inhibitor, suggesting the involvement of the GFR/PTK (GP signaling pathway. These two GP inhibitors also inhibited PMC and SMC spreading to individual cells after ingression, but the dissociation of PMC and SMC from the epithelium was not inhibited. In suramin-treated embryos, dissociated mesenchyme cells migrated partially by retaining their epithelial morphology. In HA-treated embryos, no mesenchyme cells migrated. Thus, the EMT occurs in relation to internalization of Epith-2 from presumptive PMC and SMC.

  16. Primary staging of prostate cancer

    Energy Technology Data Exchange (ETDEWEB)

    Jager, G.J. [Dept. of Radiology, Univ. Hospital, Nijmegen (Netherlands); Barentz, J.O. [Dept. of Radiology, Univ. Hospital, Nijmegen (Netherlands); Ruijter, E.T.G. [Dept. of Urology, Univ. Hospital, Nijmegen (Netherlands)]|[Dept. of Pathology, Univ. Hospital, Nijmegen (Netherlands); Rosette, J.J.M.C.H. de la [Dept. of Urology, Univ. Hospital, Nijmegen (Netherlands); Oosterhof, G.O.N. [Dept. of Urology, Univ. Hospital, Nijmegen (Netherlands)


    Staging prostate cancer is a systematic classification of the extent of disease based on clinical and pathological criteria. Despite general acceptance of the TNM staging system, a lot of controversy and uncertainty with respect to staging still exists. This paper gives an overview of differnt staging modalities and emphasizes the need for incorporation of prognostic factors, such as tumour grade and volume, in the staging system. (orig.)

  17. A New Model for the Genesis of Natural Gases——Multi-source Overlap, Multi-stage Continuity, TypeControlled by Main Source and Nomenclature by Main Stage (Ⅱ)——Multi-stage Continuity and Nomenclature by Main Stage

    Institute of Scientific and Technical Information of China (English)

    徐永昌; 沈平


    The generation of natural gases involves several stages and the various stages are of continuous transition. This is another feature of natural gas generation. The term "multi-stage" is relative mainly to oil-generating threshold value and liquid window. The evolution of organic matter is affected by different epigene agencies and natural gases differing in geochemical properties such as biogenic gas (bacterial gas), thermocatalytic gas and pyrolytic gas could be produced at different stages of the evolution of organic matter. The proposal of bio-thermocatalytic transitional-zone gas presents a pattern of mutual linking and continuous transition of natural gases originated at different stages.In the genetic classification of natural gases, the nomenclature of a certain gas is based mainly on the epigene agency which is responsible for its formation, for example, biogenic gas, pyrolytic gas. That is the "nomenclature by the main stage" described in this study. On account of the continuity of gas generati

  18. Corporate governance cycles during transition

    DEFF Research Database (Denmark)

    Jones, Derek C.; Mygind, Niels


    is faster in Estonia and this can be explained by the relatively fast pace of institutional change and evolution of important gov-ernance institutions, including tough bankruptcy legislation and advances in the financial system. JEL-codes: G3, J5, P2, P3 Keywords: corporate governance, life......We begin by identifying a typical governance life-cycle, defined as changes in ownership structure, and including both the identity of the major owner and ownership concentration. The cycle is marked by key events and phases including start-up, initial growth, mature growth, and possibly a crisis...... and restructuring stage or exit stage. The governance cycle for transitional countries reflects some specific characteristics -e.g. often privatization produces specific initial ownership structures, with an unusually high proportion of insider, especially, employee ownership. Subsequently pres...

  19. Deconfinement Phase Transition Heating and Thermal Evolution of Neutron Stars

    CERN Document Server

    Kang, Miao; Wang, Xiaodong


    The deconfinement phase transition will lead to the release of latent heat during spins down of neutron stars if the transition is the first-order one.We have investigated the thermal evolution of neutron stars undergoing such deconfinement phase transition. The results show that neutron stars may be heated to higher temperature.This feature could be particularly interesting for high temperature of low-magnetic field millisecond pulsar at late stage.

  20. Staging interrail mobilities

    DEFF Research Database (Denmark)

    Jensen, Martin Trandberg; Gyimóthy, Szilvia; Jensen, Ole B.


    studies of rail travel, by exploring how interrail travel is embedded in, and (im)mobilised by socio-material environments and institutional design decisions. More precisely, it explores the affordances of three objects that shape interrail mobility: the interrail pass, the RailPlanner application......This article applies the multiscalar ‘staging mobilities’ framework from the emergent subfield of mobilities design to analyse an enduring European rail travel phenomenon, interrail. This discussion extends and contributes to tourism mobilities research. Second, the article enriches previous...... and seat reservations. To reach these aims, the research design intertwines multi-sited ethnography, netnography, survey and interviews. The conclusion offers theoretical reflections pertaining to the role of mobilities designs and methodical hybrids in tourism mobilities research....

  1. CalCOFI Egg Stages (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Egg morphological developmental stage for eggs of selected species captured in CalCOFI icthyoplankton nets. Sequential developmental stages are described by Moser...

  2. On primordial equation of state transitions

    CERN Document Server

    Aravind, Aditya; Paban, Sonia


    We revisit the physics of transitions from a general equation of state parameter to the final stage of slow-roll inflation. We show that it is unlikely for the modes comprising the cosmic microwave background to contain imprints from a pre-inflationary equation of state transition and still be consistent with observations. We accomplish this by considering observational consistency bounds on the amplitude of excitations resulting from such a transition. As a result, the physics which initially led to inflation likely cannot be probed with observations of the cosmic microwave background. Furthermore, we show that it is unlikely that equation of state transitions may explain the observed low multipole power suppression anomaly.

  3. Staged urethroplasty: indications and techniques. (United States)

    Secrest, Charles L


    There is still a place for staged urethroplasty. There are some indications for staged urethral reconstruction such as strictures associated with chronic inflammation, fistula, false passage, urethral stones, urethral diverticula, abscess, failed prior repair, complicated hypospadias, severe trauma, neurologic diseases, extensive BXO strictures and long strictures. Staging a urethroplasty should not be considered a step backwards rather instead we should learn from experience and realize there are some patients who are too complex to reconstruct in a single stage.

  4. Large Eddy Simulation of Transitional Boundary Layer (United States)

    Sayadi, Taraneh; Moin, Parviz


    A sixth order compact finite difference code is employed to investigate compressible Large Eddy Simulation (LES) of subharmonic transition of a spatially developing zero pressure gradient boundary layer, at Ma = 0.2. The computational domain extends from Rex= 10^5, where laminar blowing and suction excites the most unstable fundamental and sub-harmonic modes, to fully turbulent stage at Rex= 10.1x10^5. Numerical sponges are used in the neighborhood of external boundaries to provide non-reflective conditions. Our interest lies in the performance of the dynamic subgrid scale (SGS) model [1] in the transition process. It is observed that in early stages of transition the eddy viscosity is much smaller than the physical viscosity. As a result the amplitudes of selected harmonics are in very good agreement with the experimental data [2]. The model's contribution gradually increases during the last stages of transition process and the dynamic eddy viscosity becomes fully active and dominant in the turbulent region. Consistent with this trend the skin friction coefficient versus Rex diverges from its laminar profile and converges to the turbulent profile after an overshoot. 1. Moin P. et. al. Phys Fluids A, 3(11), 2746-2757, 1991. 2. Kachanov Yu. S. et. al. JFM, 138, 209-247, 1983.

  5. Numerical Study of Transition of an Annular Lift Fan Aircraft

    Directory of Open Access Journals (Sweden)

    Yun Jiang


    Full Text Available The present study aimed at studying the transition of annular lift fan aircraft through computational fluid dynamics (CFD simulations. The oscillations of lift and drag, the optimization for the figure of merit, and the characteristics of drag, yawing, rolling and pitching moments in transition are studied. The results show that a two-stage upper and lower fan lift system can generate oscillations of lift and drag in transition, while a single-stage inner and outer fan lift system can eliminate the oscillations. The characteristics of momentum drag of the single-stage fans in transition are similar to that of the two-stage fans, but with the peak of drag lowered from 0.63 to 0.4 of the aircraft weight. The strategy to start transition from a negative angle of attack −21° further reduces the peak of drag to 0.29 of the weight. The strategy also reduces the peak of pitching torque, which needs upward extra thrusts of 0.39 of the weight to eliminate. The peak of rolling moment in transition needs differential upward thrusts of 0.04 of the weight to eliminate. The requirements for extra thrusts in transition lead to a total thrust–weight ratio of 0.7, which makes the aircraft more efficient for high speed cruise flight (higher than 0.7 Ma.

  6. The Managerial Transition. (United States)

    Kneeland, Steven J.


    Having identified the problem of managerial transition in a previous article (CE 510 277), the author outlines a strategy for change which includes performance appraisal, definition of the management structure, and counselling for the individual in transition. (SK)

  7. Marital transitions. A child's perspective. (United States)

    Hetherington, E M; Stanley-Hagan, M; Anderson, E R


    Despite a recent leveling off of the divorce rate, almost half of the children born in the last decade will experience the divorce of their parents, and most of these children will also experience the remarriage of their parents. Most children initially experience their parents' marital rearrangements as stressful; however, children's responses to their parents marital transitions are diverse. Whereas some exhibit remarkable resiliency and in the long term may actually be enhanced by coping with these transitions, others suffer sustained developmental delays or disruptions. Others appear to adapt well in the early stages of family reorganizations but show delayed effects that emerge at a later time, especially in adolescence. The long-term effects are related more to the child's developmental status, sex, and temperament; the qualities of the home and parenting environments; and to the resources and support systems available to the parents and child than they are to divorce or remarriage per se. In recent years, researchers have begun to move away from the view that single-parent and remarried families are atypical or pathogenic families and are focusing on the diversity of children's responses and to the factors that facilitate or disrupt the development and adjustment of children experiencing their parents' marital transitions.

  8. Science on stage

    CERN Multimedia


    During the opening ceremony, the audience was dazzled by a juggling show involving dramatic light effects. They also took away with them a teacher's sheet explaining some of the scientific concepts involved in juggling. Science teachers can sometimes be quite humorous when it comes to explaining serious matters, as those who took part in the 'Science on Stage' festival held at CERN from 21 to 25 November were able to see for themselves. The 500 or so participants from 27 different countries, mostly science teachers but also some university lecturers, science outreach specialists and students, had the opportunity to share their experience of the teaching of science. They also attended presentations and shows, took part in workshops and visited a fair with stands offering ideas on how to make school science lessons more appealing. The festival, organised by the EIROforum (a partnership between CERN, EFDA, ESA, ESO, EMBL, ESRF and ILL), marked the end of two years of projects for the promotion of science in vir...

  9. Space Launch System Upper Stage Technology Assessment (United States)

    Holladay, Jon; Hampton, Bryan; Monk, Timothy


    discussed in light of the various missions. For each mission there are several trajectory options and each will be discussed in terms of delta-v required and transit duration. Each propulsion system will be modeled, sized, and judged based on their applicability to the whole range of beyond LEO missions. Criteria for scoring will include the resulting dry mass of the stage, resulting propellant required, time to destination, and an assessment of key enabling technologies. In addition to the larger metrics, this paper will present the results of several coupled sensitivity studies. The ultimate goals of these tools and studies are to provide NASA with the most mass-, technology-, and cost-effective in-space stage for its future exploration missions.

  10. Bevacizumab, Cisplatin, Radiation Therapy, and Fluorouracil in Treating Patients With Stage IIB, Stage III, Stage IVA, or Stage IVB Nasopharyngeal Cancer (United States)


    Stage II Squamous Cell Carcinoma of the Nasopharynx; Stage III Lymphoepithelioma of the Nasopharynx; Stage III Squamous Cell Carcinoma of the Nasopharynx; Stage IV Lymphoepithelioma of the Nasopharynx; Stage IV Squamous Cell Carcinoma of the Nasopharynx

  11. Transitivity of Preferences (United States)

    Regenwetter, Michel; Dana, Jason; Davis-Stober, Clintin P.


    Transitivity of preferences is a fundamental principle shared by most major contemporary rational, prescriptive, and descriptive models of decision making. To have transitive preferences, a person, group, or society that prefers choice option "x" to "y" and "y" to "z" must prefer "x" to "z". Any claim of empirical violations of transitivity by…


    Institute of Scientific and Technical Information of China (English)

    朱佩君; 郑永光; 陶祖钰


    Typhoon Winnie (1997) experienced three stages after landfall on China: weakening, transition, and re-intensification. The transition is similar to the "complex transition" model proposed by Matano and Sekioka. During the re-intensification stage, the transformed cyclone developed into a pattern of Shapiro-Keyser Cyclone model. From the diagnosis we can find that the cause of Winnie's transition is the intrusion of cold air from the mid- and upper- troposphere and the warm temperature advection in the lower. Winnie redeveloped after transition,which is the result of three vital factors: the warm temperature advection in the lower troposphere, the divergence on the right side of the upper jet entry and the cyclonic vorticity advection in the upper.

  13. Transitive spaces of operators

    CERN Document Server

    Davidson, K R; Radjavi, H


    We investigate algebraic and topological transitivity and, more generally, k-transitivity for linear spaces of operators. In finite dimensions, we determine minimal dimensions of k-transitive spaces for every k, and find relations between the degree of transitivity of a product or tensor product on the one hand and those of the factors on the other. We present counterexamples to some natural conjectures. Some infinite dimensional analogues are discussed. A simple proof is given of Arveson's result on the weak-operator density of transitive spaces that are masa bimodules.

  14. Transition Theory – Sustainable Transition of Socio-Technical Systems

    DEFF Research Database (Denmark)

    Søndergård, Bent; Holm, Jesper; Stauning, Inger


    Theories of transition management, transition studies and social practise theory Applied to studies of hosuing and construction......Theories of transition management, transition studies and social practise theory Applied to studies of hosuing and construction...

  15. Analysis of stage specific protein expression during babesia bovis development within rhipicephalus microplus female ticks (United States)

    Arthropod borne pathogens have a complex life cycle that includes asexual reproduction of haploid stages in mammalian erythrocytes and development of diploid stages in the vector. Transition of Apicomplexan pathogens between the mammalian host and the arthropod vector is critical for ongoing transmi...

  16. Staged membrane oxidation reactor system (United States)

    Repasky, John Michael; Carolan, Michael Francis; Stein, VanEric Edward; Chen, Christopher Ming-Poh


    Ion transport membrane oxidation system comprising (a) two or more membrane oxidation stages, each stage comprising a reactant zone, an oxidant zone, one or more ion transport membranes separating the reactant zone from the oxidant zone, a reactant gas inlet region, a reactant gas outlet region, an oxidant gas inlet region, and an oxidant gas outlet region; (b) an interstage reactant gas flow path disposed between each pair of membrane oxidation stages and adapted to place the reactant gas outlet region of a first stage of the pair in flow communication with the reactant gas inlet region of a second stage of the pair; and (c) one or more reactant interstage feed gas lines, each line being in flow communication with any interstage reactant gas flow path or with the reactant zone of any membrane oxidation stage receiving interstage reactant gas.

  17. Staged Repository Development Programmes

    Energy Technology Data Exchange (ETDEWEB)

    Isaacs, T


    Programs to manage and ultimately dispose of high-level radioactive wastes are unique from scientific and technological as well as socio-political aspects. From a scientific and technological perspective, high-level radioactive wastes remain potentially hazardous for geological time periods-many millennia-and scientific and technological programs must be put in place that result in a system that provides high confidence that the wastes will be isolated from the accessible environment for these many thousands of years. Of course, ''proof'' in the classical sense is not possible at the outset, since the performance of the system can only be known with assurance, if ever, after the waste has been emplaced for those geological time periods. Adding to this challenge, many uncertainties exist in both the natural and engineered systems that are intended to isolate the wastes, and some of the uncertainties will remain regardless of the time and expense in attempting to characterize the system and assess its performance. What was perhaps underappreciated in the early days of waste management and repository program development were the unique and intense reactions that the institutional, political, and public bodies would have to repository program development, particularly in programs attempting to identify and then select sites for characterization, design, licensing, and ultimate development. Reactions in most nations were strong, focused, unrelenting, and often successful in hindering, derailing, and even stopping national repository programs. The reasons for such reactions and the measures to successfully respond to them are still evolving and continue to be the focus of many national program and political leaders. Adaptive Staging suggests an approach to repository program development that reflects the unique challenges associated with the disposal of high-level radioactive waste. The step-wise, incremental, learn-as-you-go approach is intended to

  18. Objective malignancy grading of squamous cell carcinoma of the lung. Stereologic estimates of mean nuclear size are of prognostic value, independent of clinical stage of disease

    DEFF Research Database (Denmark)

    Ladekarl, M; Bæk-Hansen, T; Henrik-Nielsen, R


    BACKGROUND: The prognostic value of quantitative histopathologic parameters was evaluated in 55 consecutively treated patients with operable lung carcinoma of squamous (N = 39) and mixed, adenosquamous (N = 16) cell type. Patients alive were followed for at least 12 years. METHODS: Using a projec......BACKGROUND: The prognostic value of quantitative histopathologic parameters was evaluated in 55 consecutively treated patients with operable lung carcinoma of squamous (N = 39) and mixed, adenosquamous (N = 16) cell type. Patients alive were followed for at least 12 years. METHODS: Using...... of nuclei to tissue, and the number of mitotic profiles per 10(3) nuclear profiles. For each patient, information was recorded regarding sex, age at diagnosis, and clinical stage of disease. RESULTS: Single-factor analyses showed that a favorable prognosis was associated with early clinical stages (Stages I...... volume were found to be parameters of significant, independent prognostic value. CONCLUSIONS: The present feasibility study indicates that estimates of the mean nuclear volume are of prognostic value, independent of the clinical stage of disease. This quantitative histopathologic variable is highly...

  19. Carboplatin and Paclitaxel With or Without Cisplatin and Radiation Therapy in Treating Patients With Stage I, Stage II, Stage III, or Stage IVA Endometrial Cancer (United States)


    Endometrial Clear Cell Adenocarcinoma; Endometrial Serous Adenocarcinoma; Stage IA Uterine Corpus Cancer; Stage IB Uterine Corpus Cancer; Stage II Uterine Corpus Cancer; Stage IIIA Uterine Corpus Cancer; Stage IIIB Uterine Corpus Cancer; Stage IIIC Uterine Corpus Cancer; Stage IVA Uterine Corpus Cancer

  20. Significant change of sensitivity index d' in sensory processing of human brain during wake-sleep transition

    Institute of Scientific and Technical Information of China (English)

    Chuang Gao; Fengjuan Zhang; Wei Wei; Yang Zhang; Shanyu Ke


    The sensor area in the brain remains active during the wake-sleep transition. However, the behavioral mechanisms of sensor sensitivity involved in the transition from a state of wakefulness to a sleep state remain poorly understood. To detect sensitivity index (d') changes during the wake-sleep transition, the present study recorded response times of wakefulness versus wake-sleep transition in 14 healthy undergraduate volunteers. During wake-sleep transition testing, morphological changes in the time courses of behavior response revealed 2 typical phases (stages A and B). In stage A, subject behavior responses exhibited temporal fluctuations, and all subjects displayed a high accuracy rate. In stage B, subjects did not exhibit behavioral responses. The sensitivity index d' during the wake-sleep transition (stage A) was significantly weaker than during wakefulness. Results demonstrated that at the behavioral level, sensation capacity for transfer information from the external world into the internal system significantly decreased during the transition to sleep.

  1. Safety models incorporating graph theory based transit indicators. (United States)

    Quintero, Liliana; Sayed, Tarek; Wahba, Mohamed M


    There is a considerable need for tools to enable the evaluation of the safety of transit networks at the planning stage. One interesting approach for the planning of public transportation systems is the study of networks. Network techniques involve the analysis of systems by viewing them as a graph composed of a set of vertices (nodes) and edges (links). Once the transport system is visualized as a graph, various network properties can be evaluated based on the relationships between the network elements. Several indicators can be calculated including connectivity, coverage, directness and complexity, among others. The main objective of this study is to investigate the relationship between network-based transit indicators and safety. The study develops macro-level collision prediction models that explicitly incorporate transit physical and operational elements and transit network indicators as explanatory variables. Several macro-level (zonal) collision prediction models were developed using a generalized linear regression technique, assuming a negative binomial error structure. The models were grouped into four main themes: transit infrastructure, transit network topology, transit route design, and transit performance and operations. The safety models showed that collisions were significantly associated with transit network properties such as: connectivity, coverage, overlapping degree and the Local Index of Transit Availability. As well, the models showed a significant relationship between collisions and some transit physical and operational attributes such as the number of routes, frequency of routes, bus density, length of bus and 3+ priority lanes.

  2. Predictability of Critical Transitions

    CERN Document Server

    Zhang, Xiaozhu; Hallerberg, Sarah


    Critical transitions in multistable systems have been discussed as models for a variety of phenomena ranging from the extinctions of species to socio-economic changes and climate transitions between ice-ages and warm-ages. From bifurcation theory we can expect certain critical transitions to be preceded by a decreased recovery from external perturbations. The consequences of this critical slowing down have been observed as an increase in variance and autocorrelation prior to the transition. However especially in the presence of noise it is not clear, whether these changes in observation variables are statistically relevant such that they could be used as indicators for critical transitions. In this contribution we investigate the predictability of critical transitions in conceptual models. We study the the quadratic integrate-and-fire model and the van der Pol model, under the influence of external noise. We focus especially on the statistical analysis of the success of predictions and the overall predictabil...

  3. Gravitationally induced quantum transitions (United States)

    Landry, A.; Paranjape, M. B.


    In this paper, we calculate the probability for resonantly inducing transitions in quantum states due to time-dependent gravitational perturbations. Contrary to common wisdom, the probability of inducing transitions is not infinitesimally small. We consider a system of ultracold neutrons, which are organized according to the energy levels of the Schrödinger equation in the presence of the Earth's gravitational field. Transitions between energy levels are induced by an oscillating driving force of frequency ω . The driving force is created by oscillating a macroscopic mass in the neighborhood of the system of neutrons. The neutron lifetime is approximately 880 sec while the probability of transitions increases as t2. Hence, the optimal strategy is to drive the system for two lifetimes. The transition amplitude then is of the order of 1.06 ×10-5, and hence with a million ultracold neutrons, one should be able to observe transitions.

  4. Gravitationally induced quantum transitions

    CERN Document Server

    Landry, A


    In this letter, we calculate the probability for resonantly induced transitions in quantum states due to time dependent gravitational perturbations. Contrary to common wisdom, the probability of inducing transitions is not infinitesimally small. We consider a system of ultra cold neutrons (UCN), which are organized according to the energy levels of the Schr\\"odinger equation in the presence of the earth's gravitational field. Transitions between energy levels are induced by an oscillating driving force of frequency $\\omega$. The driving force is created by oscillating a macroscopic mass in the neighbourhood of the system of neutrons. The neutrons decay in 880 seconds while the probability of transitions increase as $t^2$. Hence the optimal strategy is to drive the system for 2 lifetimes. The transition amplitude then is of the order of $1.06\\times 10^{-5}$ hence with a million ultra cold neutrons, one should be able to observe transitions.

  5. Stage movement following a 5A's intervention in tobacco dependent individuals with serious mental illness (SMI). (United States)

    DiClemente, Carlo C; Delahanty, Janine C; Kofeldt, Miranda G; Dixon, Lisa; Goldberg, Richard; Lucksted, Alicia


    Smoking among individuals with serious mental illness (SMI) creates significant health problems. This study explored stage of change transitions over time among smokers with serious mental illness (SMI) and how dose of a brief intervention and other psychosocial variables were related to stage transitions. Participants were a subsample of 110 patients who participated in a larger controlled trial (Dixon, et al., 2009) examining whether psychiatrists in mental health clinics implementing the "5A's" (Ask, Advise, Assess, Assist, and Arrange) significantly reduced smoking among persons with SMI. Participants were classified into one of the Transtheoretical Model (TTM) Stages of Change for Smoking Cessation as well as classified into groups based upon the pattern of stage status transitions over time (i.e., Regressors, Stable, Inconsistent, Progressors with and without a successful quit). Modest quit rates for this brief intervention were found at one-year (6.4%) and the dose of the intervention was meaningfully related to positive stage transitions. Cessation outcomes from the controlled trial (Dixon, et al., 2009) indicated a small effect on smoking cessation, which is confirmed in this stage transition secondary analysis with a subset of these smokers. However, these results suggest that a brief intervention delivered by psychiatrists in a mental health treatment setting does seem to make an impact on these smokers.

  6. Lernpunkt Deutsch--Stage 1. (United States)

    Theil, Elvira


    Evaluates the first stage of "Lernpunkt Deutsch," a new three-stage German course designed for upper elementary and early secondary school. Describes the publisher's package of materials and the appropriateness of the course, utility of the different package elements, format of the materials, and assesses whether the course provides pedagogically…

  7. Writing Stages: A Developmental Hierarchy. (United States)

    Milner, Joseph O.

    The developmental stages of writing can be related to Jean Piaget's final three stages of development (preoperational, concrete operational, and formal operational) and to the narrative, descriptive, explanative, analytical, and artistic rhetorical modes. As the child enters kindergarten or the first grade, narrative blooms. By this age most young…

  8. Turning Forbidden Transitions into Dominant Transitions

    CERN Document Server

    Rivera, Nicholas; Soljacic, Marin


    Surface phonon polaritons are hybrid modes of photons and optical phonons that can propagate on the surface of a polar dielectric. In this work, we show that the precise combination of confinement and bandwidth offered by surface phonon polaritons allows for the ability to take forbidden transitions and turn them into the primary means by which an electron emits light. We show that high-order multipolar transitions and two-photon emission processes can be over an order of magnitude faster than competing dipole transitions, as opposed to being as much as eight to ten orders of magnitude slower in free space. Our results have direct implications for the design of fundamentally new types of emitters in the mid and far IR: ones which prefer to change their angular momentum by large amounts and also ones that prefer to emit a relatively broad spectrum of entangled photons - potentially allowing for new sources of both single and multiple photons.

  9. Multi-stage complex contagions (United States)

    Melnik, Sergey; Ward, Jonathan A.; Gleeson, James P.; Porter, Mason A.


    The spread of ideas across a social network can be studied using complex contagion models, in which agents are activated by contact with multiple activated neighbors. The investigation of complex contagions can provide crucial insights into social influence and behavior-adoption cascades on networks. In this paper, we introduce a model of a multi-stage complex contagion on networks. Agents at different stages—which could, for example, represent differing levels of support for a social movement or differing levels of commitment to a certain product or idea—exert different amounts of influence on their neighbors. We demonstrate that the presence of even one additional stage introduces novel dynamical behavior, including interplay between multiple cascades, which cannot occur in single-stage contagion models. We find that cascades—and hence collective action—can be driven not only by high-stage influencers but also by low-stage influencers.

  10. Hemodialysis as a rite of transition

    Directory of Open Access Journals (Sweden)

    Esperanza Vélez Vélez


    Full Text Available This article intends to explore the conceptual and practical application of the rites of transition model in the care of renal patients on hemodialysis treatment in our cultural environment. An ethnographic approach and narrative qualitative methodology were used, with an interpretation grounded in the constructivist paradigm. By convenient sampling, twelve patients on hemodialysis treatment were selected The immersion in hemodialysis culture and the observation process were done in the hemodialysis unit and also at patients’ home , where the in-depth interviews were carried out. The analysis of patients’ narratives shows the three stages of the rites of transition: separation, transition and reincorporation. The metaphoric usefulness of this model’s application and its possible influence on the quality of care offered to these patients is argued.

  11. Transit Benefit Program Data - (United States)

    Department of Transportation — This data set contains information about any US government agency participating in the transit benefits program, funding agreements, individual participating Federal...

  12. Staging of unipolar affective illness

    Directory of Open Access Journals (Sweden)

    Ewa Ferensztajn


    Full Text Available In this article, a concept of staging of unipolar affective illness (recurrent depression is presented. In respective subchapters, three most important aspects of this issue have been discussed: 1 staging of unipolar affective illness; 2 staging of treatment-resistant depression; and 3 conversion of unipolar into bipolar affective illness. The evidence for so called neuroprogression of the illness, accumulated in recent years, has allowed for a classification of staging based on a concept of allostasis and allostatic load. In the course of illness, changes in neuroendocrine system (mainly hypothalamic pituitary-adrenal (HPA axis, immunological system, mechanisms of oxidative stress, neurotransmitters, neurotrophic factors as well as structural and functional changes of the brain occur. In their paper of 2007, Fava and Tossani elaborated a concept of staging of unipolar affective illness presenting a continuum model of five consecutive stages with specific clinical features. In the present paper, a concept of treatment-resistant depression and staging of treatment resistance is presented in the context of several models. An important determinant of treatment-resistant depression is so called subthreshold bipolarity which is connected with worse efficacy of antidepressant drugs. In the course of illness, there is a possibility of changing diagnosis from recurrent depression into bipolar affective illness. The studies on this issue show that frequency of such diagnostic conversion is 1,5% of depressed patients per year.

  13. Single Cell Proteomics Using Frog (Xenopus laevis) Blastomeres Isolated from Early Stage Embryos, Which Form a Geometric Progression in Protein Content. (United States)

    Sun, Liangliang; Dubiak, Kyle M; Peuchen, Elizabeth H; Zhang, Zhenbin; Zhu, Guijie; Huber, Paul W; Dovichi, Norman J


    Single cell analysis is required to understand cellular heterogeneity in biological systems. We propose that single cells (blastomeres) isolated from early stage invertebrate, amphibian, or fish embryos are ideal model systems for the development of technologies for single cell analysis. For these embryos, although cell cleavage is not exactly symmetric, the content per blastomere decreases roughly by half with each cell division, creating a geometric progression in cellular content. This progression forms a ladder of single-cell targets for the development of successively higher sensitivity instruments. In this manuscript, we performed bottom-up proteomics on single blastomeres isolated by microdissection from 2-, 4-, 8-, 16-, 32-, and 50-cell Xenopus laevis (African clawed frog) embryos. Over 1 400 protein groups were identified in single-run reversed-phase liquid chromatography-electrospray ionization-tandem mass spectrometry from single balstomeres isolated from a 16-cell embryo. When the mass of yolk-free proteins in single blastomeres decreased from ∼0.8 μg (16-cell embryo) to ∼0.2 μg (50-cell embryo), the number of protein group identifications declined from 1 466 to 644. Around 800 protein groups were quantified across four blastomeres isolated from a 16-cell embryo. By comparing the protein expression among different blastomeres, we observed that the blastomere-to-blastomere heterogeneity in 8-, 16-, 32-, and 50-cell embryos increases with development stage, presumably due to cellular differentiation. These results suggest that comprehensive quantitative proteomics on single blastomeres isolated from these early stage embryos can provide valuable insights into cellular differentiation and organ development.

  14. Staging procedures in mycosis fungoides

    Energy Technology Data Exchange (ETDEWEB)

    Griem, M.L.; Moran, E.M.; Ferguson, D.J.; Mettler, F.A.; Griem, S.F.


    Mycosis fungoides (MF) in deep-seated lymph nodes, spleen or liver appears to be associated with a lack of response of the disease to topical external therapy. Fourteen patients with mycosis fungoides were clinically staged and had a staging laparotomy. Myosis fungoides was found in the lymph nodes of 3 of these patients, in the spleen in 4 and in the liver of 2 cases. Patients with adenopathy, or with splenomegaly or abnormal spleen scans, should be considered for surgical staging to determine the extent of extracutaneous disease. The documentation of extracutaneous MF becomes necessary in the development of new therapeutic approaches. (auth)

  15. Origins of evolutionary transitions

    Indian Academy of Sciences (India)

    Ellen Clarke


    An `evolutionary transition in individuality’ or `major transition’ is a transformation in the hierarchical level at which natural selection operates on a population. In this article I give an abstract (i.e. level-neutral and substrate-neutral) articulation of the transition process in order to precisely understand how such processes can happen, especially how they can get started.

  16. Matter in transition (United States)

    Anderson, Lara B.; Gray, James; Raghuram, Nikhil; Taylor, Washington


    We explore a novel type of transition in certain 6D and 4D quantum field theories, in which the matter content of the theory changes while the gauge group and other parts of the spectrum remain invariant. Such transitions can occur, for example, for SU(6) and SU(7) gauge groups, where matter fields in a three-index antisymmetric representation and the fundamental representation are exchanged in the transition for matter in the two-index antisymmetric representation. These matter transitions are realized by passing through superconformal theories at the transition point. We explore these transitions in dual F-theory and heterotic descriptions, where a number of novel features arise. For example, in the heterotic description the relevant 6D SU(7) theories are described by bundles on K3 surfaces where the geometry of the K3 is constrained in addition to the bundle structure. On the F-theory side, non-standard representations such as the three-index antisymmetric representation of SU( N) require Weierstrass models that cannot be realized from the standard SU( N) Tate form. We also briefly describe some other situations, with groups such as Sp(3), SO(12), and SU(3), where analogous matter transitions can occur between different representations. For SU(3), in particular, we find a matter transition between adjoint matter and matter in the symmetric representation, giving an explicit Weierstrass model for the F-theory description of the symmetric representation that complements another recent analogous construction.

  17. Transition Texture Synthesis

    Institute of Scientific and Technical Information of China (English)

    Yueh-Yi Lai; Wen-Kai Tai


    Synthesis of transition textures is essential for displaying visually acceptable appearances on a terrain. This investigation presents a modified method for synthesizing the transition texture to be tiled on a terrain. All transition pattern types are recognized for a number of input textures. The proposed modified patch-based sampling texture synthesis approach, using the extra feature map of the input source and target textures for patch matching, can synthesize any transition texture on a succession pattern by initializing the output texture using a portion of the source texture enclosed in a transition cut. The transition boundary is further enhanced to improve the visual effect by tracing out the integral texture elements. Either the Game of Life model or Wang tiles method are exploited to present a good-looking profile of successions on a terrain for tiling transition textures. Experimental results indicate that the proposed method requires few input textures, yet synthesizes numerous tileable transition textures, which are useful for obtaining a vivid appearance of a terrain.

  18. Transition radiation by neutrinos

    Energy Technology Data Exchange (ETDEWEB)

    Ioannisian, A.N., E-mail: [Yerevan Physics Institute, Alikhanian Br. 2, 375036 Yerevan (Armenia); CERN, Theory Division, CH-1211 Geneva 23 (Switzerland); Institute for Theoretical Physics and Modeling, 375036 Yerevan (Armenia); Ioannisian, D.A. [Yerevan Physics Institute, Alikhanian Br. 2, 375036 Yerevan (Armenia); Institute for Theoretical Physics and Modeling, 375036 Yerevan (Armenia); Physics Department, Yerevan State University, 1 Alex Manoogian (Armenia); Kazarian, N.A. [Institute for Theoretical Physics and Modeling, 375036 Yerevan (Armenia)


    We calculate the transition radiation process {nu}{yields}{nu}{gamma} at an interface of two media. The neutrinos are taken to be with only standard-model couplings. The medium fulfills the dual purpose of inducing an effective neutrino-photon vertex and of modifying the photon dispersion relation. The transition radiation occurs when at least one of those quantities have different values in different media. The neutrino mass is ignored due to its negligible contribution. We present a result for the probability of the transition radiation which is both accurate and analytic. For E{sub {nu}=}1 MeV neutrino crossing polyethylene-vacuum interface the transition radiation probability is about 10{sup -39} and the energy intensity is about 10{sup -34} eV. At the surface of the neutron stars the transition radiation probability may be {approx}10{sup -20}. Our result is by the three orders of magnitude larger than those of previous calculations.

  19. Transition radiation by neutrinos (United States)

    Ioannisian, A. N.; Ioannisian, D. A.; Kazarian, N. A.


    We calculate the transition radiation process ν→νγ at an interface of two media. The neutrinos are taken to be with only standard-model couplings. The medium fulfills the dual purpose of inducing an effective neutrino-photon vertex and of modifying the photon dispersion relation. The transition radiation occurs when at least one of those quantities have different values in different media. The neutrino mass is ignored due to its negligible contribution. We present a result for the probability of the transition radiation which is both accurate and analytic. For Eν=1 MeV neutrino crossing polyethylene-vacuum interface the transition radiation probability is about 10 and the energy intensity is about 10 eV. At the surface of the neutron stars the transition radiation probability may be ˜10. Our result is by the three orders of magnitude larger than those of previous calculations.

  20. Life stage, not climate change, explains observed tree range shifts. (United States)

    Máliš, František; Kopecký, Martin; Petřík, Petr; Vladovič, Jozef; Merganič, Ján; Vida, Tomáš


    Ongoing climate change is expected to shift tree species distribution and therefore affect forest biodiversity and ecosystem services. To assess and project tree distributional shifts, researchers may compare the distribution of juvenile and adult trees under the assumption that differences between tree life stages reflect distributional shifts triggered by climate change. However, the distribution of tree life stages could differ within the lifespan of trees, therefore, we hypothesize that currently observed distributional differences could represent shifts over ontogeny as opposed to climatically driven changes. Here, we test this hypothesis with data from 1435 plots resurveyed after more than three decades across the Western Carpathians. We compared seedling, sapling and adult distribution of 12 tree species along elevation, temperature and precipitation gradients. We analyzed (i) temporal shifts between the surveys and (ii) distributional differences between tree life stages within both surveys. Despite climate warming, tree species distribution of any life stage did not shift directionally upward along elevation between the surveys. Temporal elevational shifts were species specific and an order of magnitude lower than differences among tree life stages within the surveys. Our results show that the observed range shifts among tree life stages are more consistent with ontogenetic differences in the species' environmental requirements than with responses to recent climate change. The distribution of seedlings substantially differed from saplings and adults, while the distribution of saplings did not differ from adults, indicating a critical transition between seedling and sapling tree life stages. Future research has to take ontogenetic differences among life stages into account as we found that distributional differences recently observed worldwide may not reflect climate change but rather the different environmental requirements of tree life stages.

  1. CalCOFI Larvae Stages (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Developmental stages (yolk sac, preflexion, flexion, postflexion, or transformation) of selected fish larvae captured in CalCOFI icthyoplankton nets.

  2. Stage-dependent remodeling of the nuclear envelope and lamina during rabbit early embryonic development. (United States)

    Popken, Jens; Schmid, Volker J; Strauss, Axel; Guengoer, Tuna; Wolf, Eckhard; Zakhartchenko, Valeri


    Utilizing 3D structured illumination microscopy, we investigated the quality and quantity of nuclear invaginations and the distribution of nuclear pores during rabbit early embryonic development and identified the exact time point of nucleoporin 153 (NUP153) association with chromatin during mitosis. Contrary to bovine early embryonic nuclei, featuring almost exclusively nuclear invaginations containing a small volume of cytoplasm, nuclei in rabbit early embryonic stages show additionally numerous invaginations containing a large volume of cytoplasm. Small-volume invaginations frequently emanated from large-volume nuclear invaginations but not vice versa, indicating a different underlying mechanism. Large- and small-volume nuclear envelope invaginations required the presence of chromatin, as they were restricted to chromatin-positive areas. The chromatin-free contact areas between nucleolar precursor bodies (NPBs) and large-volume invaginations were free of nuclear pores. Small-volume invaginations were not in contact with NPBs. The number of invaginations and isolated intranuclear vesicles per nucleus peaked at the 4-cell stage. At this stage, the nuclear surface showed highly concentrated clusters of nuclear pores surrounded by areas free of nuclear pores. Isolated intranuclear lamina vesicles were usually NUP153 negative. Cytoplasmic, randomly distributed NUP153-positive clusters were highly abundant at the zygote stage and decreased in number until they were almost absent at the 8-cell stage and later. These large NUP153 clusters may represent a maternally provided NUP153 deposit, but they were not visible as clusters during mitosis. Major genome activation at the 8- to 16-cell stage may mark the switch from a necessity for a deposit to on-demand production. NUP153 association with chromatin is initiated during metaphase before the initiation of the regeneration of the lamina. To our knowledge, the present study demonstrates for the first time major remodeling

  3. The multipolar stage and disruptions in neuronal migration. (United States)

    LoTurco, Joseph J; Bai, Jilin


    The genetic basis is now known for several disorders of neuronal migration in the developing cerebral cortex. Identification of the cellular processes mediated by the implicated genes is revealing crucial stages of neuronal migration and has the potential to reveal common cellular causes of neuronal migration disorders. We hypothesize that a newly recognized morphological stage of neuronal migration, the multipolar stage, is vulnerable and is disrupted in several disorders of neocortical development. The multipolar stage occurs as bipolar progenitor cells become radially migrating neurons. Several studies using in utero electroporation and RNAi have revealed that transition out of the multipolar stage depends on the function of filamin A, LIS1 and DCX. Mutations in the genes encoding these proteins in humans cause distinct neuronal migration disorders, including periventricular nodular heterotopia, subcortical band heterotopia and lissencephaly. The multipolar stage therefore seems to be a critical point of migration control and a vulnerable target for disruption of neocortical development. This review is part of the INMED/TINS special issue "Nature and nurture in brain development and neurological disorders", based on presentations at the annual INMED/TINS symposium (

  4. Staged regenerative sorption heat pump (United States)

    Jones, Jack A. (Inventor)


    A regenerative adsorbent heat pump process and system for cooling and heating a space. A sorbent is confined in a plurality of compressors of which at least four are first stage and at least four are second stage. The first stage operates over a first pressure region and the second stage over a second pressure region which is higher than the first. Sorbate from the first stage enters the second stage. The sorbate loop includes a condenser, expansion valve, evaporator and the compressors. A single sorbate loop can be employed for single-temperature-control such as air conditioning and heating. Two sorbate loops can be used for two-temperature-control as in a refrigerator and freezer. The evaporator temperatures control the freezer and refrigerator temperatures. Alternatively the refrigerator temperature can be cooled by the freezer with one sorbate loop. A heat transfer fluid is circulated in a closed loop which includes a radiator and the compressors. Low temperature heat is exhausted by the radiator. High temperature heat is added to the heat transfer fluid entering the compressors which are desorbing vapor. Heat is transferred from compressors which are sorbing vapor to the heat transfer fluid, and from the heat transfer fluid to the compressors which are desorbing vapor. Each compressor is subjected to the following phases, heating to its highest temperature, cooling down from its highest temperature, cooling to its lowest temperature, and warming up from its lowest temperature. The phases are repeated to complete a cycle and regenerate heat.

  5. Bipolar disorder: staging and neuroprogression

    Directory of Open Access Journals (Sweden)

    Rodrigues, Aline André


    Full Text Available In bipolar disorder illness progression has been associated with a higher number of mood episodes and hospitalizations, poorer response to treatment, and more severe cognitive and functional impairment. This supports the notion of the use of staging models in this illness. The value of staging models has long been recognized in many medical and malignant conditions. Staging models rely on the fact that different interventions may suit different stages of the disorder, and that better outcomes can be obtained if interventions are implemented earlier in the course of illness. Thus, treatment planning would benefit from the assessment of cognition, functioning and comorbidities. Staging may offer a means to refine treatment options, and most importantly, to establish a more precise diagnosis. Moreover, staging could have utility as course specifier and may guide treatment planning and better information to patients and their family members of what could be expected in terms of prognosis. The present study reviews the clinical and biological basis of the concept of illness progression in bipolar disorder.

  6. Development of a cost effective microscope heater stage (United States)

    Dugre, Joshua; Prayaga, Chandra; Wade, Aaron

    Utilizing 3D printing technology, a heater stage has been developed and implemented for microscopic systems. Due to the flexibility of 3D printing,the heater stage can be easily modified to fit any sample size with only slight modifications to the heating element being required. The sample in contact with the heating element can also easily be secured in a thermal insulator, such as aluminum foil. The thermal gradient of the heater stage has been recorded to be less than 1°C and has been compared to more expensive designs, and the cost effectiveness of the system has been determined. The system has been tested with a sample of the liquid crystal 8CB in order to determine the exact temperatures of the phase transitions of the crystal to verify that the system is applicable to a wide range of experimental physics. UWF Quality Enhancement Plan Award.

  7. Predictability of critical transitions (United States)

    Zhang, Xiaozhu; Kuehn, Christian; Hallerberg, Sarah


    Critical transitions in multistable systems have been discussed as models for a variety of phenomena ranging from the extinctions of species to socioeconomic changes and climate transitions between ice ages and warm ages. From bifurcation theory we can expect certain critical transitions to be preceded by a decreased recovery from external perturbations. The consequences of this critical slowing down have been observed as an increase in variance and autocorrelation prior to the transition. However, especially in the presence of noise, it is not clear whether these changes in observation variables are statistically relevant such that they could be used as indicators for critical transitions. In this contribution we investigate the predictability of critical transitions in conceptual models. We study the quadratic integrate-and-fire model and the van der Pol model under the influence of external noise. We focus especially on the statistical analysis of the success of predictions and the overall predictability of the system. The performance of different indicator variables turns out to be dependent on the specific model under study and the conditions of accessing it. Furthermore, we study the influence of the magnitude of transitions on the predictive performance.

  8. Martensitic phase transitions

    Energy Technology Data Exchange (ETDEWEB)

    Petry, W.; Neuhaus, J. [Techn. Universitaet Muenchen, Physik Department E13, Munich (Germany)


    Many elements transform from a high temperature bcc phase to a more dense packed temperature phase. The great majority of these transitions are of 1st order, displacive and reconstructive. The lattice potentials which govern these martensitic transitions can be probed by inelastic neutron scattering, thereby answering fundamental questions like : Will the transition be announced by dynamical or static fluctuations? What are the trajectories for the displacements needed for the transformation? Does the vibrational entropy stabilize the high temperature phase? Are the unusual transport properties in these materials related to their ability to transform? (author) 17 figs., 1 tab., 46 refs.

  9. Anomalous radiative transitions

    CERN Document Server

    Ishikawa, Kenzo; Tobita, Yutaka


    Anomalous transitions involving photons derived by many-body interaction of the form, $\\partial_{\\mu} G^{\\mu}$, in the standard model are studied. This does not affect the equation of motion in the bulk, but makes wave functions modified, and causes the unusual transition characterized by the time-independent probability. In the transition probability at a time-interval T expressed generally in the form $P=T \\Gamma_0 +P^{(d)}$, now with $\\Gamma_0=0, P^{(d)} \

  10. Transition nozzle combustion system

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Won-Wook; McMahan, Kevin Weston; Maldonado, Jaime Javier


    The present application provides a combustion system for use with a cooling flow. The combustion system may include a head end, an aft end, a transition nozzle extending from the head end to the aft end, and an impingement sleeve surrounding the transition nozzle. The impingement sleeve may define a first cavity in communication with the head end for a first portion of the cooling flow and a second cavity in communication with the aft end for a second portion of the cooling flow. The transition nozzle may include a number of cooling holes thereon in communication with the second portion of the cooling flow.

  11. Variational Transition State Theory

    Energy Technology Data Exchange (ETDEWEB)

    Truhlar, Donald G. [Univ. of Minnesota, Minneapolis, MN (United States)


    This is the final report on a project involving the development and applications of variational transition state theory. This project involved the development of variational transition state theory for gas-phase reactions, including optimized multidimensional tunneling contributions and the application of this theory to gas-phase reactions with a special emphasis on developing reaction rate theory in directions that are important for applications to combustion. The development of variational transition state theory with optimized multidimensional tunneling as a useful computational tool for combustion kinetics involved eight objectives.

  12. Transition feeding of sows

    DEFF Research Database (Denmark)

    Theil, Peter Kappel


    becomes catabolic due to the high priority of milk production and to current feeding practices. Indeed, feed is changed from a gestation to a lactation diet for most sows and the feed supply typically goes from a restricted supply to an ad libitum allowance. In addition, transition sows are often exposed...... the first few days of lactation, and milk yield increases throughout the transition period and becomes the most important determinant of nutrient requirements. Thus, nutrient requirements of transition sows are affected by many intrinsic factors and these requirements change rapidly, yet, sow feeding...... practices do not acknowledge these changes. Development of new feeding strategies specifically adapted for the transition sow is likely of importance to match the rapid changes in nutrient requirements....

  13. Melting of Transition Metals

    Energy Technology Data Exchange (ETDEWEB)

    Ross, M; Japel, S; Boehler, R


    We review the transition melting studies carried out at Mainz, and describe a recently developed model used to explain that the relatively low melting slopes are due to the partially filled d-bands, and the persistence of the pressure induced s-d transition. The basic tenets of the model have now been reconfirmed by new measurements for Cu and Ni. The measurements show that Cu which has a filled 3d-band, has a melt slope that is about 2.5 greater than its neighbor Ni. In the case of Mo, the apparent discrepancy of DAC melting measurements with shock melting can be explained by accounting for the change in melt slope due to the bcc-cp transition observed in the shock studies. The Fe melt curve is revisited. The possible relevance of the Jahn-Teller effect and recently observed transition metal melts with Icosahedral Short-Range Order (ISRO) is discussed.

  14. Transitivity on Weierstrass points

    CERN Document Server

    Laing, Zoe


    We look for Riemann surfaces whose automorphism group acts transitively on the Weierstrass points. We concentrate on hyperelliptic surfaces, surfaces with PSL(2, q) as automorphism group, Platonic surfaces and Fermat curves.

  15. Transiting Exoplanets with JWST

    CERN Document Server

    Seager, S; Valenti, J A


    The era of exoplanet characterization is upon us. For a subset of exoplanets -- the transiting planets -- physical properties can be measured, including mass, radius, and atmosphere characteristics. Indeed, measuring the atmospheres of a further subset of transiting planets, the hot Jupiters, is now routine with the Spitzer Space Telescope. The James Webb Space Telescope (JWST) will continue Spitzer's legacy with its large mirror size and precise thermal stability. JWST is poised for the significant achievement of identifying habitable planets around bright M through G stars--rocky planets lacking extensive gas envelopes, with water vapor and signs of chemical disequilibrium in their atmospheres. Favorable transiting planet systems, are, however, anticipated to be rare and their atmosphere observations will require tens to hundreds of hours of JWST time per planet. We review what is known about the physical characteristics of transiting planets, summarize lessons learned from Spitzer high-contrast exoplanet m...

  16. Phase transitions modern applications

    CERN Document Server

    Gitterman, Moshe


    This book provides a comprehensive review of the theory of phase transitions and its modern applications, based on the five pillars of the modern theory of phase transitions i.e. the Ising model, mean field, scaling, renormalization group and universality. This expanded second edition includes, along with a description of vortices and high temperature superconductivity, a discussion of phase transitions in chemical reaction and moving systems. The book covers a close connection between phase transitions and small world phenomena as well as scale-free systems such as the stock market and the Internet. Readership: Scientists working in different fields of physics, chemistry, biology and economics as well as teaching material for undergraduate and graduate courses.

  17. Oligocyclopentadienyl transition metal complexes

    Energy Technology Data Exchange (ETDEWEB)

    de Azevedo, Cristina G.; Vollhardt, K. Peter C.


    Synthesis, characterization, and reactivity studies of oligocyclopentadienyl transition metal complexes, namely those of fulvalene, tercyclopentadienyl, quatercyclopentadienyl, and pentacyclopentadienyl(cyclopentadienyl) are the subject of this account. Thermal-, photo-, and redox chemistries of homo- and heteropolynuclear complexes are described.

  18. Superconductivity in transition metals. (United States)

    Slocombe, Daniel R; Kuznetsov, Vladimir L; Grochala, Wojciech; Williams, Robert J P; Edwards, Peter P


    A qualitative account of the occurrence and magnitude of superconductivity in the transition metals is presented, with a primary emphasis on elements of the first row. Correlations of the important parameters of the Bardeen-Cooper-Schrieffer theory of superconductivity are highlighted with respect to the number of d-shell electrons per atom of the transition elements. The relation between the systematics of superconductivity in the transition metals and the periodic table high-lights the importance of short-range or chemical bonding on the remarkable natural phenomenon of superconductivity in the chemical elements. A relationship between superconductivity and lattice instability appears naturally as a balance and competition between localized covalent bonding and so-called broken covalency, which favours d-electron delocalization and superconductivity. In this manner, the systematics of superconductivity and various other physical properties of the transition elements are related and unified.

  19. Transitions in Energy Use


    Grubler, A.


    Patterns of energy use have changed dramatically since the onset of the industrial revolution in terms of both energy quantities and energy quality. These changing patterns of energy use, where energy quantities and quality interact in numerous important ways, are referred to in this article as energy transitions and are described from a historical perspective as well as through future scenarios. Far from being completed, many of these transitions are continuing to unfold in industrial and de...

  20. The SAT phase transition

    Institute of Scientific and Technical Information of China (English)

    许可; 李未


    Phase transition is an important feature of SAT problem. For random k-SAT model, it is proved that as r(ratio of clauses to variables) increases, the structure of solutions will undergo a sudden change like satisfiability phase transition when r reaches a threshold point (r=rcr). This phenomenon shows that the satisfying truth assignments suddenly shift from being relatively different from each other to being very similar to each other.##属性不符

  1. The WFCAM Transit Survey

    Directory of Open Access Journals (Sweden)

    Hodgkin S.


    Full Text Available The WFCAM Transit Survey (WTS has been obtaining data on the United Kingdom Infrared Telescope since 2007. The WTS targets about 8,000 M dwarfs over several square degrees of sky, and aims to find low-mass eclipsing binaries and planets, down to the size of the Earth, transiting M dwarf stars with periods up to a few days.

  2. Stateless Transitive Signature Schemes

    Institute of Scientific and Technical Information of China (English)

    MA Chun-guang; CAI Man-chun; YANG Yi-xian


    A new practical method is introduced to transform the stateful transitive signature scheme to stateless one without the loss of security. According to the approach, two concrete stateless transitive signature schemes based on Factoring and RSA are presented respectively. Under the assumption of the hardness of factoring and one-more- RSA-inversion problem, both two schemes are secure under the adaptive chosen-message attacks in random oracle model.

  3. Matter in transition

    CERN Document Server

    Anderson, Lara B; Raghuram, Nikhil; Taylor, Washington


    We explore a novel type of transition in certain 6D and 4D quantum field theories, in which the matter content of the theory changes while the gauge group and other parts of the spectrum remain invariant. Such transitions can occur, for example, for SU(6) and SU(7) gauge groups, where matter fields in a three-index antisymmetric representation and the fundamental representation are exchanged in the transition for matter in the two-index antisymmetric representation. These matter transitions are realized by passing through superconformal theories at the transition point. We explore these transitions in dual F-theory and heterotic descriptions, where a number of novel features arise. For example, in the heterotic description the relevant 6D SU(7) theories are described by bundles on K3 surfaces where the geometry of the K3 is constrained in addition to the bundle structure. On the F-theory side, non-standard representations such as the three-index antisymmetric representation of SU(N) require Weierstrass models...

  4. Staging N0 oral cancer

    DEFF Research Database (Denmark)

    Thomsen, Jørn Bo; Sørensen, Jens Ahm; Grupe, Peter


    PURPOSE: To compare sentinel lymph node biopsy, magnetic resonance imaging (MRI), Doppler ultrasonography, and palpation as staging tools in patients with T1/T2 N0 cancer of the oral cavity. MATERIAL AND METHODS: Forty consecutive patients were enrolled (17 F and 23 M, aged 32-90 years), 24 T1......%, but the sensitivity of MRI 36% was low. The specificities were 100%, 85%, and 93%, respectively. By combined sentinel lymph node biopsy and ultrasonography the overall sensitivity could have been 100%. CONCLUSION: Sentinel lymph node biopsy improved staging of patients with small N0 oral cancers. Combined sentinel...

  5. Mixing and Transition Control Studied (United States)


    Considerable progress in understanding nonlinear phenomena in both unbounded and wallbounded shear flow transition has been made through the use of a combination of high- Reynolds-number asymptotic and numerical methods. The objective of this continuing work is to fully understand the nonlinear dynamics so that ultimately (1) an effective means of mixing and transition control can be developed and (2) the source terms in the aeroacoustic noise problem can be modeled more accurately. Two important aspects of the work are that (1) the disturbances evolve from strictly linear instability waves on weakly nonparallel mean flows so that the proper upstream conditions are applied in the nonlinear or wave-interaction streamwise region and (2) the asymptotic formulations lead to parabolic problems so that the question of proper out-flow boundary conditions--still a research issue for direct numerical simulations of convectively unstable shear flows--does not arise. Composite expansion techniques are used to obtain solutions that account for both mean-flow-evolution and nonlinear effects. A previously derived theory for the amplitude evolution of a two-dimensional instability wave in an incompressible mixing layer (which is in quantitative agreement with available experimental data for the first nonlinear saturation stage for a plane-jet shear layer, a circular-jet shear layer, and a mixing layer behind a splitter plate) have been extended to include a wave-interaction stage with a three-dimensional subharmonic. The ultimate wave interaction effects can either give rise to explosive growth or an equilibrium solution, both of which are intimately associated with the nonlinear self-interaction of the three dimensional component. The extended theory is being evaluated numerically. In contrast to the mixing-layer situation, earlier comparisons of theoretical predictions based on asymptotic methods and experiments in wall-bounded shear-flow transition have been somewhat lacking

  6. The Staging of the Turk

    DEFF Research Database (Denmark)

    Holm, Bent


    An analytical and contextualized presentation of the figure of the Turk on the Danish stage in the 18. century with a specific focus on the interaction between the actual commercial and military circumstances on the one hand and the performative representations on the other hand. How far did the ...

  7. When science takes centre stage

    CERN Multimedia


    The teachers at 'Science on stage' are not emotionally attached to their chalk. Neither are they are weary old men who sport tweed jackets with elbow-patches and enter into conversation with their blackboards. Actually, 'Science on stage' teachers are far from the cliché of the boring physics teacher who can only inspire yawns from his pupils. Some present the basic principles of mechanics using a bicycle, others explain chemistry with examples from everyday life. The most audacious of them go so far as to explain the Doppler effect by means of a play in which Einstein dreams about jumping cows... These are but a few of the activities and plays that will be shown during the EIROforum1 Science on Stage Festival (organised by 7 European scientific organisations including CERN), to be held from 21 to 25 November at CERN, Geneva. This festival is dedicated to the teaching science in order to make it more attractive. After the first edition 'Physics on Stage' which was held in 2000 at CERN, the laboratory agai...

  8. Drama for Classroom and Stage. (United States)

    Johnson, Albert and Bertha

    This book with a three-part format contains information which the would-be thespian needs to know for maximum enjoyment and success in stage activities. The first part, "Heritage," traces the history and development of the theater from primitive ritual through the drama of classical Greece and Rome, the Renaissance, and modern Europe and America,…

  9. Conflict Frequency and Relationship Quality across the Transition to Parenthood (United States)

    Kluwer, Esther S.; Johnson, Matthew D.


    Longitudinal data from 293 Dutch couples were used to examine the association between conflict frequency and relationship quality across the transition to parenthood, which is known as one of the most challenging events in the early stages of marriage. More frequent conflict during pregnancy was related to lower levels of relationship quality…

  10. Applications of Motivational Interviewing in Career Counseling: Facilitating Career Transition (United States)

    Stoltz, Kevin B.; Young, Tabitha L.


    The Protean and Boundaryless career paradigms are calling for new ways to provide career counseling to clients. Career counselors need methods for facilitating client's career transition across all stages of career development. This facilitation requires career counselors to be armed with methods for promoting client's autonomy,…

  11. Еconomic situation of the Ukrainian gas transit

    Directory of Open Access Journals (Sweden)

    Schegolkova A. A.


    Full Text Available The economic and geopolitical features of the present stage of development of the Ukrainian gas transit to the Western Europe have been studied. The directions of modernization of the transport system of Arctic natural gas in terms of the development of new routes and means of delivery have been substantiated

  12. Social connectedness and the transition from work to retirement

    NARCIS (Netherlands)

    Lancee, B.; Radl, J.


    Objectives. Although there are numerous studies on the role of social connections in early working life, research that examines how social connectedness matters in the later stages of a career is scarce. The present study analyzes to what extent social connectedness affects the timing of the transit

  13. The periodontal prosthesis mode of transition to an implant-supported dentition. (United States)

    Hunt, Peter; Norkin, Frederic; Serrano, Julian


    In recent years, implant-supported reconstructions have become a welcome alternative to dentures for those who have lost their natural dentition. While the benefits of the final implant-supported reconstruction may be obvious, the planning and execution of therapy to achieve this result may be bewildering to many dentists. Four main modes of transfer have evolved: an uncontrolled or "haphazard" transition; the traditional "dentures first" mode, an immediate transition, and a staged transition. This article proposes an additional mode of transition called periodontal prosthesis, which has the potential to make the transition process smoother and more predictable while providing optimal retention of alveolar supporting structures and generating optimal esthetics.

  14. Gradual meiosis-to-mitosis transition in the early mouse embryo. (United States)

    Courtois, Aurélien; Hiiragi, Takashi


    The transition from meiosis to mitosis is a fundamental process to guarantee the successful development of the embryo. In the mouse, the transition includes extensive reorganisation of the division machinery, centrosome establishment and changes in spindle proprieties and characteristic. Recent findings indicate that this transition is gradual and lasts until the late blastocyst stage. In-depth knowledge of the mechanisms underlying the transition would provide new insight into de novo centrosome formation and regulation of spindle size and proprieties. Here, we review recent advances in the understanding of acentrosomal spindle formation, centriole establishment and the meiosis-to-mitosis transition in the mouse pre-implantation embryo.

  15. Examining hydrogen transitions.

    Energy Technology Data Exchange (ETDEWEB)

    Plotkin, S. E.; Energy Systems


    This report describes the results of an effort to identify key analytic issues associated with modeling a transition to hydrogen as a fuel for light duty vehicles, and using insights gained from this effort to suggest ways to improve ongoing modeling efforts. The study reported on here examined multiple hydrogen scenarios reported in the literature, identified modeling issues associated with those scenario analyses, and examined three DOE-sponsored hydrogen transition models in the context of those modeling issues. The three hydrogen transition models are HyTrans (contractor: Oak Ridge National Laboratory), MARKAL/DOE* (Brookhaven National Laboratory), and NEMS-H2 (OnLocation, Inc). The goals of these models are (1) to help DOE improve its R&D effort by identifying key technology and other roadblocks to a transition and testing its technical program goals to determine whether they are likely to lead to the market success of hydrogen technologies, (2) to evaluate alternative policies to promote a transition, and (3) to estimate the costs and benefits of alternative pathways to hydrogen development.

  16. Scaling ansatz for the jamming transition. (United States)

    Goodrich, Carl P; Liu, Andrea J; Sethna, James P


    We propose a Widom-like scaling ansatz for the critical jamming transition. Our ansatz for the elastic energy shows that the scaling of the energy, compressive strain, shear strain, system size, pressure, shear stress, bulk modulus, and shear modulus are all related to each other via scaling relations, with only three independent scaling exponents. We extract the values of these exponents from already known numerical or theoretical results, and we numerically verify the resulting predictions of the scaling theory for the energy and residual shear stress. We also derive a scaling relation between pressure and residual shear stress that yields insight into why the shear and bulk moduli scale differently. Our theory shows that the jamming transition exhibits an emergent scale invariance, setting the stage for the potential development of a renormalization group theory for jamming.

  17. Scaling ansatz for the jamming transition (United States)

    Goodrich, Carl P.; Liu, Andrea J.; Sethna, James P.


    We propose a Widom-like scaling ansatz for the critical jamming transition. Our ansatz for the elastic energy shows that the scaling of the energy, compressive strain, shear strain, system size, pressure, shear stress, bulk modulus, and shear modulus are all related to each other via scaling relations, with only three independent scaling exponents. We extract the values of these exponents from already known numerical or theoretical results, and we numerically verify the resulting predictions of the scaling theory for the energy and residual shear stress. We also derive a scaling relation between pressure and residual shear stress that yields insight into why the shear and bulk moduli scale differently. Our theory shows that the jamming transition exhibits an emergent scale invariance, setting the stage for the potential development of a renormalization group theory for jamming.

  18. Numerical Simulation of Multi-Stage Turbomachinery Flows (United States)

    Adamczyk, John J.; Hathaway, Michael D.; Shabbir, Aamir; Wellborn, Steven R.


    A comprehensive assessment is made of the predictive capability of the average passage flow model as applied to multi-stage axial flow compressors. The average passage flow model describes the time average flow field within a typical passage of a blade row embedded in a multi-stage configuration. In this work data taken within a four and one-half stage large low speed compressor will be used to assess the weakness and strengths of the predictive capabilities of the average passage flow model. The low speed compressor blading is of modern design and employs stators with end-bends. Measurements were made with slow and high response instrumentation. The high response measurements revealed the velocity components of both the rotor and stator wakes. Based on the measured wake profiles it will be argued that blade boundary layer transition is playing an important role in setting compressor performance. A model which mimics the effects of blade boundary layer transition within the frame work of the average passage model will be presented. Simulations which incorporated this model showed a dramatic improvement in agreement with data.

  19. Parametric modal transition systems

    DEFF Research Database (Denmark)

    Beneš, Nikola; Křetínský, Jan; Larsen, Kim Guldstrand;


    Modal transition systems (MTS) is a well-studied specification formalism of reactive systems supporting a step-wise refinement methodology. Despite its many advantages, the formalism as well as its currently known extensions are incapable of expressing some practically needed aspects in the refin......Modal transition systems (MTS) is a well-studied specification formalism of reactive systems supporting a step-wise refinement methodology. Despite its many advantages, the formalism as well as its currently known extensions are incapable of expressing some practically needed aspects...... in the refinement process like exclusive, conditional and persistent choices. We introduce a new model called parametric modal transition systems (PMTS) together with a general modal refinement notion that overcome many of the limitations and we investigate the computational complexity of modal refinement checking....

  20. Citizens in sustainable transitions

    DEFF Research Database (Denmark)

    Hoffmann, Birgitte; Agger, Annika


    The paper explores how local public authorities can support and facilitate citizens’ participa-tion and learning in sustainable transition in urban neighbourhoods, by supporting local in-termediaries. The role of intermediaries can be performed by a variety of actors such as public housing...... associations; NGO´s, or semi public institutions. Our claim is that intermediary actors have the potential to facilitate new platforms for citizens’ participation in urban sustainable transition due to their particular role in between public authorities and civil society. The key question of the paper is how...... the intermediary actors facilitate citizens' participatory processes in sustainable urban transitions, and the paper explores the concept of institutional capacity building as a way to develop learning processes and new practises? The aim is to analyse approaches of creating platforms for involving citizens...

  1. Responses to Change Helping People Make Transitions

    CERN Document Server

    (CCL), Center for Creative Leadership


    The ongoing state of many organizations is one of change. People who experience major change tend to exhibit one of four patterns of response: entrenched, overwhelmed, poser, or learner. As a leader, you need to understand the patterns of response that people express and to customize intervention strategies to help them make the transition. People can pass through a given response stage and move to one that is more effective--especially if you provide timely intervention and support. This guidebook will help you understand how people, including yourself, are responding to change and what you c

  2. China's urban transition. (United States)

    Pannell, C


    This article describes recent changes in urban patterns in Shanghai-Nanjing, Beijing-Tianjin-Tangshan, Canton-Hong Kong, and Dalian-Shenyang. The urban patterns in these metropolitan areas are viewed as part of an urban transition that is responding to population growth, a structural shift in employment, relaxed rules on migration and household registration, and foreign investment and trade. It is argued that these metropolitan coastal areas will form the key growth centers and will lead China's economic development. Urban transition is defined as the shift from rural to urban and from agricultural employment to industrial, commercial, or service employment. China's large cities always dominated as important centers of politics and trade. The recent shift is from interior to coastal cities due to a new world view and a movement away from the isolationism of prior centuries. It is assumed that cities are formed to take advantage of economies of scale in production, consumption, and distribution and to conform to regional specialization. Governments can intervene in growth processes. China's development of cities reflects state controls and market forces. The size and scale of China's population influenced the development process, which resulted in differences in the shape and process of the urban transition. It was under Chinese communism that cities became more than a set of discrete regional urban systems. Reference is made to Oshima's model of change that is specific to monsoon countries. Oshima argues that monsoon agricultural conditions require a distinct strategy based on full employment in order to achieve industrial transition. Rice cultivation requires a large and disciplined labor force. The discussion focuses on other models as well, such as the McGee's model of the extended metropolis and its extension by Zhou Yixing to China. China's changes may not follow Skeldon's models of urbanization in developing countries, because of state control of migration

  3. Transition Satisfaction and Family Well Being among Parents of Young Adults with Severe Intellectual Disability (United States)

    Neece, Cameron L.; Kraemer, Bonnie R.; Blacher, Jan


    The transition from high school to adulthood is a critical life stage that entails many changes, especially for youth with severe intellectual disability. The transition period may be especially stressful for the families of these young adults, who often experience a sudden change, or decrease, in services. However, little research has examined…

  4. Improving transition between power optimization and power limitation of variable speed/variable pitch wind turbines

    Energy Technology Data Exchange (ETDEWEB)

    Hansen, A.D.; Bindner, H. [Risoe National Lab., Wind Energy and Atmospheric Physics Dept., Roskilde (Denmark); Rebsdorf, A. [Vestas Wind Systems A/S, Lem (Denmark)


    The paper summarises and describes the main results of a recently performed study of improving the transition between power optimization and power limitation for variable speed/variable pitch wind turbines. The results show that the capability of varying the generator speed also can be exploited in the transition stage to improve the quality of the generated power. (au)

  5. Electronic phase transitions

    CERN Document Server

    Kopaev, YuV


    Electronic Phase Transitions deals with topics, which are presently at the forefront of scientific research in modern solid-state theory. Anderson localization, which has fundamental implications in many areas of solid-state physics as well as spin glasses, with its influence on quite different research activities such as neural networks, are two examples that are reviewed in this book. The ab initio statistical mechanics of structural phase transitions is another prime example, where the interplay and connection of two unrelated disciplines of solid-state theory - first principle ele

  6. Spin transition in [Fe (United States)

    Garcia, Y.; Ksenofontov, V.; Campbell, S. J.; Lord, J. S.; Boland, Y.; Gütlich, P.


    The reversible thermal spin transition which occurs in [Fe(phen)2(NCS)2] around T1/2 177 K has been investigated by muon spin relaxation (μSR) (10-280 K). The depolarisation curves are well described by two Lorentzian lines represent fast and slow components in the decay curves, with the initial asymmetry parameter of the fast component found to track the spin transition in [Fe(phen)2(NCS)2]. Comparison of zero-field and transverse field (20 Oe) μSR measurements shows that diamagnetic muonic species occur over the entire temperature range.

  7. Lost in Transit

    DEFF Research Database (Denmark)

    Lange, Ida Sofie Gøtzsche; Laursen, Lea Louise Holst; Lassen, Claus

    Thinking of Transit Places, the first sites that comes to mind will probably be airports, train stations and motorways. Such places are overall mono-functional with the embedded rationales of people's desires to move (themselves or goods) from one place to another. Often different service functions...... how a town primarily characterized by ferry transit is being challenged on its capacity to be a 'place' of meaning and social importance to its inhabitants. The paper raises the key question: Can a place become too well connected and this in such a manner that its identity and key character becomes...

  8. Pinocchio: Geppetto's transitional object

    Directory of Open Access Journals (Sweden)

    Gabriele Zeloni


    Full Text Available The literature has been considered by Freud and others after him, a form of unaware exploration of mind that can leads to discoveries similar to psychoanalysis’s discoveries. From this perspective, the author puts forward the following hypothesis: Pinocchio is a puppet who comes to life and is therefore, from a child's perception, a transitional object according to Winnicott. Consequently Geppetto is nothing more than the involuntary representation of any child interacting with the transitional object. The author explains the results of the analysis of the text in support of the hypothesis and reflects on the impact of The adventure of Pinocchio on the reader.

  9. Transition to the Cloud

    DEFF Research Database (Denmark)

    Hedman, Jonas; Xiao, Xiao


    companies operate. In this paper, we present a case study of an ERP vendor for SMB (small and mediumsize business) in making a transition towards a cloud-based business model. Through the theoretical lens of ecosystem, we are able to analyze the evolution of the vendor and its business network as a whole......The rising of cloud computing has dramatically changed the way software companies provide and distribute their IT product and related services over the last decades. Today, most software is bought offthe-shelf and distributed over the Internet. This transition is greatly influencing how software...

  10. Sleep stages, memory and learning. (United States)

    Dotto, L


    Learning and memory can be impaired by sleep loss during specific vulnerable "windows" for several days after new tasks have been learned. Different types of tasks are differentially vulnerable to the loss of different stages of sleep. Memory required to perform cognitive procedural tasks is affected by the loss of rapid-eye-movement (REM) sleep on the first night after learning occurs and again on the third night after learning. REM-sleep deprivation on the second night after learning does not produce memory deficits. Declarative memory, which is used for the recall of specific facts, is not similarly affected by REM-sleep loss. The learning of procedural motor tasks, including those required in many sports, is impaired by the loss of stage 2 sleep, which occurs primarily in the early hours of the morning. These findings have implications for the academic and athletic performance of students and for anyone whose work involves ongoing learning and demands high standards of performance.

  11. Patch stage of mycosis fungoides

    Directory of Open Access Journals (Sweden)

    Mavarkar Laxman


    Full Text Available Parapsoriasis is aeon troversial topic. There are many studies regarding the relationship of parapsoriasis to lymphoma but no correlation between histology and clinical appearance. Parapsoriasis satisfies histologic criteria for mycosis fungoides and therefore it should be considered as patch stage of mycosis fungoides. A 30-year-old man presented with scaly skin lesions over the trunk since 4 years. Routine blood and urine investigations were normal. Skin biopsy from the lesion revealed atypical lymphocytes within the epidermis without spongiosis.

  12. Sleep stages, memory and learning.


    Dotto, L


    Learning and memory can be impaired by sleep loss during specific vulnerable "windows" for several days after new tasks have been learned. Different types of tasks are differentially vulnerable to the loss of different stages of sleep. Memory required to perform cognitive procedural tasks is affected by the loss of rapid-eye-movement (REM) sleep on the first night after learning occurs and again on the third night after learning. REM-sleep deprivation on the second night after learning does n...

  13. Upper-Stage Flight Experiment (United States)

    Anderson, W. E.; Boxwell, R.; Crockett, D. V.; Ross, R.; Lewis, T.; McNeal, C.; Verdarame, K.


    For propulsion applications that require that the propellants are storable for long periods, have a high density impulse, and are environmentally clean and non-toxic, the best choice is a combination of high-concentration hydrogen peroxide (High Test Peroxide, or HTP) and a liquid hydrocarbon (LHC) fuel. The HTP/LHC combination is suitable for low-cost launch vehicles, space taxi and space maneuvering vehicles, and kick stages. Orbital Sciences Corporation is under contract with the NASA Marshall Space Flight Center in cooperation with the Air Force Research Lab to design, develop and demonstrate a new low-cost liquid upper stage based on HTP and JP-8. The Upper Stage Flight Experiment (USFE) focuses on key technologies necessary to demonstrate the operation of an inherently simple propulsion system with an innovative, state-of-the-art structure. Two key low-cost vehicle elements will be demonstrated - a 10,000 lbf thrust engine and an integrated composite tank structure. The suborbital flight test of the USFE is scheduled for 2001. Preceding the flight tests are two major series of ground tests at NASA Stennis Space Center and a subscale tank development program to identify compatible composite materials and to verify their compatibility over long periods of time. The ground tests include a thrust chamber development test series and an integrated stage test. This paper summarizes the results from the first phase of the thrust chamber development tests and the results to date from the tank material compatibility tests. Engine and tank configurations that meet the goals of the program are described.

  14. Multi-stage flash degaser (United States)

    Rapier, Pascal M.


    A multi-stage flash degaser (18) is incorporated in an energy conversion system (10) having a direct-contact, binary-fluid heat exchanger to remove essentially all of the noncondensable gases from geothermal brine ahead of the direct-contact binary-fluid heat exchanger (22) in order that the heat exchanger (22) and a turbine (48) and condenser (32) of the system (10) can operate at optimal efficiency.

  15. Percolation approach to initial stage effects in high energy collisions

    Energy Technology Data Exchange (ETDEWEB)

    Srivastava, Brijesh K.


    Possible phase transition of strongly interacting matter from hadron to a quark–gluon plasma state have in the past received considerable interest. The clustering of color sources provides a framework of the partonic interactions in the initial stage of the collisions. The onset of deconfinement transition is identified by the spanning percolation cluster in 2D percolation. In this talk results are presented both for the multiplicity and the elliptic flow at RHIC and LHC energies. The thermodynamic quantities temperature, equation of state and transport coefficient are obtained in the framework of clustering of color sources. It is shown that the results are in excellent agreement with the recent lattice QCD calculations (LQCD)

  16. Percolation Approach to Initial Stage Effects in High Energy Collisions

    CERN Document Server

    Srivastava, Brijesh K


    Possible phase transition of strongly interacting matter from hadron to a quark-gluon plasma state have in the past received considerable interest. The clustering of color sources provides a framework of the the partonic interactions in the initial stage of the collisions. The onset of de-confinement transition is identified by the spanning percolation cluster in 2D percolation. In this talk results are presented both for the multiplicity and the elliptic flow at RHIC and LHC energies. The thermodynamic quantities temperature, equation of state and transport coefficient are obtained in the framework of clustering of color sources. It is shown that the results are in excellent agreement with the recent lattice QCD calculations(LQCD).

  17. Development perspective of transitional countries

    Directory of Open Access Journals (Sweden)

    Ilić Bogdan B.


    Full Text Available The end of 20th century witnessed the affirmation and development of information technology as well as the transformation of industrial into information, "new economy", which caused changes in people and circumstances. The role and importance of nonhuman factors was increased, causing entrepreneurship and knowledge-based information to become the most significant resources. The Internet became the basis of the "new economy". It changes the way of doing business, studying, researching, communicating and competition. It also reduces operating costs, crosses national borders and leads to the globalization of the world economy. Transitional countries have to fit into modern development flows by formulating their own strategy of national development and establishing their own competitive advantages in conditions of "new economy". These advantages lie predominantly in highly qualified and skilled younger labor which learns fast and adopts new knowledge and skills, through reducing transactional costs, shortening of certain development stages through which developed countries have already gone, using their experience, scientific-technological progress, a rise in work productivity, etc. Experience of other countries should be innovated and adapted to one's own material and social conditions, not copied. This enables the emergence of "European small tigers", which are similar to "Asian small tigers".

  18. Lean-rich axial stage combustion in a can-annular gas turbine engine

    Energy Technology Data Exchange (ETDEWEB)

    Laster, Walter R.; Szedlacsek, Peter


    An apparatus and method for lean/rich combustion in a gas turbine engine (10), which includes a combustor (12), a transition (14) and a combustor extender (16) that is positioned between the combustor (12) and the transition (14) to connect the combustor (12) to the transition (14). Openings (18) are formed along an outer surface (20) of the combustor extender (16). The gas turbine (10) also includes a fuel manifold (28) to extend along the outer surface (20) of the combustor extender (16), with fuel nozzles (30) to align with the respective openings (18). A method (200) for axial stage combustion in the gas turbine engine (10) is also presented.

  19. Families in Transition. (United States)

    Britton, Patti O., Ed.; McGee, Michael, Ed.


    This issue of "Emphasis" deals with families in transition, providing some model programs for the new family and some historical perspectives on how families have developed over time. Articles include: (1) "Nostalgia on the Right" (Nancy Theriot); (2) "Heart to Heart" (Nancy Harrington-MacLennan); (3) "The Media Get the Message" (Janet Alyn); (4)…

  20. Administrative Theory in Transition. (United States)

    Griffiths, Daniel E.

    This monograph analyzes transition in educational administrative theory. A brief introductory section describes the theoretical movement, the substance and repercussions of Thomas Greenfield's critique of educational administrative theory in 1974, and emerging qualitative approaches. Seven readings, all written by the volume's author, view…

  1. Photoinduced phase transitions

    CERN Document Server

    Nasu, K


    A new class of insulating solids was recently discovered. Whenirradiated by a few visible photons, these solids give rise to amacroscopic excited domain that has new structural and electronicorders quite different from the starting ground state. This occurrenceis called "photoinduced phase transition", and this multi-authoredbook reviews recent theoretical and experimental studies of this newphenomenon.

  2. eta ' transition form factors

    NARCIS (Netherlands)

    Amo Sanchez, del P.; Raven, H.G.; Snoek, H.; BaBar, Collaboration


    eta((')) transition form factors in the momentum-transfer range from 4 to 40 GeV(2). The analysis is based on 469 fb(-1) of integrated luminosity collected at PEP-II with the BABAR detector at e(+)e(-) center-of-mass energies near 10.6 GeV.

  3. A Transiting Jupiter Analog

    CERN Document Server

    Kipping, David M; Henze, Chris; Teachey, Alex; Isaacson, Howard T; Petigura, Erik A; Marcy, Geoffrey W; Buchhave, Lars A; Chen, Jingjing; Bryson, Steve T; Sandford, Emily


    Decadal-long radial velocity surveys have recently started to discover analogs to the most influential planet of our solar system, Jupiter. Detecting and characterizing these worlds is expected to shape our understanding of our uniqueness in the cosmos. Despite the great successes of recent transit surveys, Jupiter analogs represent a terra incognita, owing to the strong intrinsic bias of this method against long orbital periods. We here report on the first validated transiting Jupiter analog, Kepler-167e (KOI-490.02), discovered using Kepler archival photometry orbiting the K4-dwarf KIC-3239945. With a radius of $(0.91\\pm0.02)$ $R_{\\mathrm{Jup}}$, a low orbital eccentricity ($0.06_{-0.04}^{+0.10}$) and an equilibrium temperature of $(131\\pm3)$ K, Kepler-167e bears many of the basic hallmarks of Jupiter. Kepler-167e is accompanied by three Super-Earths on compact orbits, which we also validate, leaving a large cavity of transiting worlds around the habitable-zone. With two transits and continuous photometric ...

  4. Variational transition state theory

    Energy Technology Data Exchange (ETDEWEB)

    Truhlar, D.G. [Univ. of Minnesota, Minneapolis (United States)


    This research program involves the development of variational transition state theory (VTST) and semiclassical tunneling methods for the calculation of gas-phase reaction rates and selected applications. The applications are selected for their fundamental interest and/or their relevance to combustion.

  5. Learning for Life Transitions (United States)

    Varmecky, Jane Hyde


    Many adults return to formal learning situations to pursue lifelong learning goals because their lives are in transition from dealing with real-life problems such as divorce and re-marriage. The purpose of this study was to describe what couples learned that contributed to the success of their subsequent marriages and how they learned it. The…

  6. Families in Transition . (United States)

    Bundy, Michael L., Ed.; Gumaer, James, Ed.


    Focuses on disrupted families and the role of the school counselor in helping children adjust. Describes characteristics of healthy families, and discusses the transition to the blended family, effects of divorce groups on children's classroom behavior, counseling children in stepfamilies, single-parent families, and parenting strengths of single…

  7. Transition and Financial Collapse

    NARCIS (Netherlands)

    Uhlig, H.F.H.V.S.


    One of the many problems facing the countries in transition from socialism to capitalism after the initial phase of privatization and restructuring is the lack of proven entrepreneurial talent in addition to a low initial level of capital. New entrepreneurs might find it hard to finance their start-

  8. Topological Transitions in Metamaterials

    CERN Document Server

    Krishnamoorthy, Harish N S; Narimanov, Evgenii; Kretzschmar, Ilona; Menon, Vinod M


    The ideas of mathematical topology play an important role in many aspects of modern physics - from phase transitions to field theory to nonlinear dynamics (1, 2). An important example of this is the Lifshitz transition (3), where the transformation of the Fermi surface of a metal from a closed to an open geometry (due to e.g. external pressure) leads to a dramatic effect on the electron magneto-transport (4). Here, we present the optical equivalent of the Lifshitz transition in strongly anisotropic metamaterials. When one of the components of the dielectric permittivity tensor of such a composite changes sign, the corresponding iso-frequency surface transforms from an ellipsoid to a hyperboloid. Since the photonic density of states can be related to the volume enclosed by the iso-frequency surface (5), such a topological transition in a metamaterial leads to a dramatic change in the photonic density of states, with a resulting effect on every single physical parameter related to the metamaterial - from thermo...

  9. Conceptions of Topological Transitivity

    CERN Document Server

    Akin, Ethan


    There are several different common definitions of a property in topological dynamics called "topological transitivity," and it is part of the folklore of dynamical systems that under reasonable hypotheses, they are equivalent. Various equivalences are proved in different places, but the full story is difficult to find. This note provides a complete description of the relationships among the different properties.

  10. Nursing Role Transition Preceptorship (United States)

    Batory, Susan M.


    The preceptorship clinical experience in a practical nursing (PN) program at a Midwestern community college is considered crucial to the PN students' transition from novice nurse to professional nurse. However, no research has been available to determine whether the preceptorship clinical accomplishes its purpose. A case study was conducted to…

  11. The Three Stages of Teaching Reading

    Institute of Scientific and Technical Information of China (English)



    If we want to improve our way of teaching, one way is to teach reading in three stages: Pre- reading stage, while-reading stage, and post- reading stage. Each stage has a different goal and deals with different reading strategies. Prereading means before the text is read. In while reading stage, we have looked at the main reading skills: skimming, scanning , reading for detail , drawing inferences about the author's purpose and intention. Post - reading stage mainly focuses on the exploitation of the text. It aims to help the reader understand the content and structure of the text, as well as the author's purpose in writing it.

  12. Frontostriatal Cognitive Staging in Parkinson's Disease

    Directory of Open Access Journals (Sweden)

    Raúl de la Fuente-Fernández


    Full Text Available Cognitive impairment and behavioural disorders are often encountered in subjects with Parkinson's disease (PD. A simple PD-related frontostriatal cognitive dysfunction (PDFCD staging is proposed. Executive dysfunction and mental fatigue (stage I, depression/anxiety (stage IIa, apathy/pain (stage IIb, and dementia (stage III reflect a sequential process of dopamine depletion occurring in different regions of the striatum (stages I and II and the frontal cortex (stage III. In addition to these nonmotor manifestations present in the unmedicated (OFF state, the PDFCD model also predicts a number of complications related to dopaminergic treatment (ON state, from impulse control disorders (stages I and IIa to hallucinations (stage IIb and psychosis (stage III. Although the model admittedly needs further refinements, it provides a framework for hypothesis testing and may help clinicians optimize therapeutic strategies.

  13. Stage-Structured Population Dynamics of AEDES AEGYPTI (United States)

    Yusoff, Nuraini; Budin, Harun; Ismail, Salemah

    Aedes aegypti is the main vector in the transmission of dengue fever, a vector-borne disease affecting world population living in tropical and sub-tropical countries. Better understanding of the dynamics of its population growth will help in the efforts of controlling the spread of this disease. In looking at the population dynamics of Aedes aegypti, this paper explored the stage-structured modeling of the population growth of the mosquito using the matrix population model. The life cycle of the mosquito was divided into five stages: eggs, larvae, pupae, adult1 and adult2. Developmental rates were obtained for the average Malaysian temperature and these were used in constructing the transition matrix for the matrix model. The model, which was based only on temperature, projected that the population of Aedes aegypti will blow up with time, which is not realistic. For further work, other factors need to be taken into account to obtain a more realistic result.

  14. Single Stage Contactor Testing Of The Next Generation Solvent Blend

    Energy Technology Data Exchange (ETDEWEB)

    Herman, D. T.; Peters, T. B.; Duignan, M. R.; Williams, M. R.; Poirier, M. R.; Brass, E. A.; Garrison, A. G.; Ketusky, E. T.


    The Modular Caustic Side Solvent Extraction (CSSX) Unit (MCU) facility at the Savannah River Site (SRS) is actively pursuing the transition from the current BOBCalixC6 based solvent to the Next Generation Solvent (NGS)-MCU solvent to increase the cesium decontamination factor. To support this integration of NGS into the MCU facility the Savannah River National Laboratory (SRNL) performed testing of a blend of the NGS (MaxCalix based solvent) with the current solvent (BOBCalixC6 based solvent) for the removal of cesium (Cs) from the liquid salt waste stream. This testing utilized a blend of BOBCalixC6 based solvent and the NGS with the new extractant, MaxCalix, as well as a new suppressor, tris(3,7dimethyloctyl) guanidine. Single stage tests were conducted using the full size V-05 and V-10 liquid-to-liquid centrifugal contactors installed at SRNL. These tests were designed to determine the mass transfer and hydraulic characteristics with the NGS solvent blended with the projected heel of the BOBCalixC6 based solvent that will exist in MCU at time of transition. The test program evaluated the amount of organic carryover and the droplet size of the organic carryover phases using several analytical methods. The results indicate that hydraulically, the NGS solvent performed hydraulically similar to the current solvent which was expected. For the organic carryover 93% of the solvent is predicted to be recovered from the stripping operation and 96% from the extraction operation. As for the mass transfer, the NGS solvent significantly improved the cesium DF by at least an order of magnitude when extrapolating the One-stage results to actual Seven-stage extraction operation with a stage efficiency of 95%.

  15. Behavior of the Lyapunov Exponent and Phase Transition in Nuclei

    Institute of Scientific and Technical Information of China (English)

    WANG Nan; WU Xi-Zhen; LI Zhu-Xia; WANG Ning; ZHUO Yi-Zhong; SUN Xiu-Quan


    Based on the quantum molecular dynamics model, we investigate the dynamical behaviors of the excited nuclear system to simulate the latter stage of heavy ion reactions, which associate with a liquid-gas phase transition. We try to search a microscopic way to describe the phase transition in realnuclei. The Lyapunov exponent is employed and examined for our purpose. We find out that the Lyapunov exponent is one of good microscopic quantities to describe the phase transition in hot nuclei. Coulomb potential and the finite size effect may give a strong influence on the critical temperature. However, the collision term plays a minor role in the process of the liquid-gas phase transition in finite systems.

  16. Considerations for a staged approach in implant dentistry. (United States)

    Drew, Howard J; Alnassar, Talal; Gluck, Kenneth; Rynar, James E


    Full-arch and partial reconstruction is demanding for the clinician and a challenge for the patient. Traditionally, teeth are extracted, and implants are placed; the patient wears a provisional removable prosthesis during implant osseointegration. The patient is left to deal with a difficult transition from a fixed dentition to a removable one, albeit temporarily. This drastic alteration can generate functional, emotional, and esthetic changes for the patient, thereby making a difficult time even more challenging. Reconstructing the dentition through a staged approach has been documented and involves strategic extractions along with the placement of several implants, but leaves select abutment teeth for a fixed provisional prosthesis. This allows for the provisional prosthesis to be tooth-supported during implant integration and later converted to an implant-supported prosthesis. In this manner, the patient will benefit from a fixed provisional prosthesis throughout the treatment process. A staged approach is contingent upon a thorough periodontal and prosthetic evaluation and work-up. Success requires proper communication between the periodontist, surgeon, restorative dentist, laboratory, and patient. A team approach is necessary for success. The protocol, advantages, and disadvantages for a staged approach to a full-arch implant-supported reconstruction are discussed. The authors also present a case to show how the staged approach can be used for sextant or quadrant rehabilitation.

  17. Single conversion stage amplifier - SICAM

    Energy Technology Data Exchange (ETDEWEB)

    Ljusev, P.


    This Ph.D. thesis presents a thorough analysis of the so called SICAM - SIngle Converter stage AMplifier approach to building direct energy conversion audio power amplifiers. The mainstream approach for building isolated audio power amplifiers today consists of isolated DC power supply and Class D amplifier, which essentially represents a two stage solution, where each of the components can be viewed as separate and independent part. The proposed SICAM solution strives for direct energy conversion from the mains to the audio output, by dedicating the operation of the components one to another and integrating their functions, so that the final audio power amplifier represents a single-stage topology with higher efficiency, lower volume, less board space, lower component count and subsequently lower cost. The SICAM approach is both applicable to non-isolated and isolated audio power amplifiers, but the problems encountered in these two cases are different. Non-isolated SICAM solutions are intended for both AC mains-connected and battery-powered devices. In non-isolated mains-connected SICAMs the main idea is to simplify the power supply or even provide integrated power factor correction (PFC) functions, while still maintaining low component stress and good audio performance by generally decreasing the input voltage level to the Class D audio power amplifier. On the other hand, non-isolated battery-powered SICAMs have to cope with the ever changing battery voltage and provide output voltage levels which are both lower and higher than the battery voltage, while still being simple and single-stage energy conversion solutions. In isolated SICAMs the isolation transformer adjusts the voltage level on the secondary side to the desired level, so the main challenges here are decreasing the size of the magnetic core and reducing the number and size of bulky reactive components as much as possible. The main focus of this thesis is directed towards the isolated SICAMs and

  18. Staging of cutaneous malignant melanoma by CT; CT-Staging kutaner maligner Melanome

    Energy Technology Data Exchange (ETDEWEB)

    Hoffend, J. [Klinikum der Stadt Ludwigshafen gGmbH, Zentralinstitut fuer diagnostische und interventionelle Radiologie, Ludwigshafen (Germany)


    Malignant melanomas are a challenge in radiological imaging diagnostics as they may metastasize into every organ and tissue. Cross-sectional imaging, in particular positron emission tomography computed tomography (PET/CT) and whole body magnetic resonance imaging (MRI), are considered the standards in the staging of melanomas. Because of its excellent availability CT, however, remains a widely employed staging modality. Familiarity with the manifold CT morphology of metastasized melanomas as it is described here is essential when interpreting dedicated CT and in addition useful when interpreting PET/CT results. In individual cases CT can assist in the detection of transient metastases. In the detection of locoregional lymph node metastases CT has a median sensitivity and specificity in meta-analyses of at best 61 % and 97 %, respectively, which is inferior to the performance of ultrasound (96 % and 99 %, respectively). According to meta-analyses, in the assessment of systemic tumor spread CT can detect the majority of metastases with a sensitivity and specificity of 51-63 % and 69-78 %, respectively, which is inferior to MRI and PET/CT. Therefore, if an exact staging is required for critical management decisions, MRI or PET/CT should be employed whenever possible. (orig.) [German] Maligne Melanome koennen in praktisch jedes Organ und Gewebe metastasieren und stellen daher eine Herausforderung fuer die radiologische Diagnostik dar. Schnittbildverfahren, bevorzugt PET/CT und MRT, werden heute als Standard in der Ausbreitungsdiagnostik von Melanomen angesehen. Wegen ihrer ubiquitaeren Verfuegbarkeit bleibt jedoch die CT ein vielfach genutztes Staginginstrument. Die Kenntnis der vielfaeltigen CT-Morphologie von Melanommetastasen, wie sie in diesem Beitrag beschrieben wird, ist ueber die dedizierte CT hinaus uebertragbar auf die von der aktuellen Leitlinie bevorzugte Bildgebung mit der PET/CT. Im Einzelfall kann die CT hilfreich bei der Detektion von In-transit

  19. Morphogenesis of early stage melanoma (United States)

    Chatelain, Clément; Amar, Martine Ben


    Melanoma early detection is possible by simple skin examination and can insure a high survival probability when successful. However it requires efficient methods for identifying malignant lesions from common moles. This paper provides an overview first of the biological and physical mechanisms controlling melanoma early evolution, and then of the clinical tools available today for detecting melanoma in vivo at an early stage. It highlights the lack of diagnosis methods rationally linking macroscopic observables to the microscopic properties of the tissue, which define the malignancy of the tumor. The possible inputs of multiscale models for improving these methods are shortly discussed.

  20. Small Stage,big Charm

    Institute of Scientific and Technical Information of China (English)


    In a world where bigger is often seen as better, entertainment, especially the world of theater, has gone full circle and returned to smaller, more cozy productions that allow both the directors and the audience more freedom of interpretation and expression. Established in 1953, the Beijing People’s Art Theater on the northern end of Wangfujing Street, Beijing’s most popular pedestrian-only commercial street, has a colorful past, cataloguing a stream of trends, thoughts and ideas on stage for 55 years. In 1995, a new concept in theater was introduced in. The former canteen of the Beijing People’s Art Theater was changed into a smaller theater.

  1. [Initial stages of steel biocorrosion]. (United States)

    Zhigletsova, S K; Rodin, V B; Kobelev, V S; Aleksandrova, N V; Rasulova, G E; Kholodenko, V P


    Initial stages of corrosion of mild steel induced by Klebsiela rhinoscleromatis BO2 were studied in various media. The effect of the microorganism was detected 8-10 h after inoculation. The number of viable cells were virtually unchanged within one month in all media, but the corrosive activity of the strain decreased. The corrosive activity of microorganisms can be determined by spectrophotometry even only after incubation for 24 h. At a low level of organic substrate, even strong colonization with microorganisms does not inevitably result in a significant damage to metals.

  2. 75 FR 76921 - Tobacco Transition Payment Program; Tobacco Transition Assessments (United States)


    ... Corporation 7 CFR Part 1463 RIN 0560-AH30 Tobacco Transition Payment Program; Tobacco Transition Assessments... Commodity Credit Corporation (CCC) is modifying the regulations for the Tobacco Transition Payment Program (TTPP) to clarify, consistent with current practice and as required by the Fair and Equitable...

  3. Map Projection Transitions

    Directory of Open Access Journals (Sweden)

    Nedjeljko Frančula


    Full Text Available Map Projection Transitions is a very successful web application about map projections. The web page ( pre­sents a world map with graticule and country borders in the oblique Aitoff projection, with the South Pole. The map is not static, but animated. The South Pole moves toward the bottom and Earth rotates around its poles. The animation lasts five seconds, after which the projection changes and movement continues for five seconds, after which the projection changes again. Names of projections appear in a separate window. There are a total of 56 projections. The South Pole eventually becomes invisible and the North Pole appears at the top. Various parts of Earth appear in the center of the map by rotating around the poles.

  4. ATLAS Transition Radiation Tracker

    CERN Multimedia


    The ATLAS transition radiation tracker is made of 300'000 straw tubes, up to 144cm long. Filled with a gas mixture and threaded with a wire, each straw is a complete mini-detector in its own right. An electric field is applied between the wire and the outside wall of the straw. As particles pass through, they collide with atoms in the gas, knocking out electrons. The avalanche of electrons is detected as an electrical signal on the wire in the centre. The tracker plays two important roles. Firstly, it makes more position measurements, giving more dots for the computers to join up to recreate the particle tracks. Also, together with the ATLAS calorimeters, it distinguishes between different types of particles depending on whether they emit radiation as they make the transition from the surrounding foil into the straws.

  5. Transition Radiation Detectors

    CERN Document Server

    Andronic, A


    We review the basic features of transition radiation and how they are used for the design of modern Transition Radiation Detectors (TRD). The discussion will include the various realizations of radiators as well as a discussion of the detection media and aspects of detector construction. With regard to particle identification we assess the different methods for efficient discrimination of different particles and outline the methods for the quantification of this property. Since a number of comprehensive reviews already exist, we predominantly focus on the detectors currently operated at the LHC. To a lesser extent we also cover some other TRDs, which are planned or are currently being operated in balloon or space-borne astro-particle physics experiments.

  6. Control of Radiationless Transitions (United States)

    Gordon, Robert J.; Seideman, Tamar


    Radiationless transitions provide a mechanism for ultrafast conversion of electronic energy into nuclear motion of a molecule. This effect results from strong vibronic mixing at geometries where two or more electronic states are degenerate (or nearly degenerate in regions of avoiding crossing).We review in this chapter different approaches to controlling such transitions. General control strategies include (1) tuning the frequency of the actinic light to enhance the yield of a specific product, (2) tailoring the properties (spectral phase and amplitude) of the excitation source to guide the generated vibrational wave packet to a specific region of the conical seam between the potential energy surfaces, and (3) modifying the shape and location of the conical intersection either by altering the chemical environment of the molecule or by introducing a strong electromagnetic field. The goals of this chapter are to reveal underlying mechanistic similarities among these general methods and to outline areas for future research.

  7. Prognostic impact of tumor MET expression among patients with stage IV gastric cancer

    DEFF Research Database (Denmark)

    Erichsen, Rune; Kelsh, Michael A; Oliner, Kelly S;


    PURPOSE: We aimed to investigate the prevalence and prognostic impact of tumor mesenchymal epithelial transition factor (MET) expression in stage IV gastric cancers in a real-world clinical setting because existing evidence is sparse. METHODS: The study included archived cancer specimens from 103...

  8. An Overview of Markov Chain Methods for the Study of Stage-Sequential Developmental Processes (United States)

    Kapland, David


    This article presents an overview of quantitative methodologies for the study of stage-sequential development based on extensions of Markov chain modeling. Four methods are presented that exemplify the flexibility of this approach: the manifest Markov model, the latent Markov model, latent transition analysis, and the mixture latent Markov model.…

  9. Longitudinal Approaches to Stages of Change Measurement: Effects on Cognitive and Behavioral Physical Activity Factors (United States)

    Parker, Philip D.; Martin, Andrew J.; Martinez, Carissa; Marsh, Herbert W.; Jackson, Susan


    The transition from school to further education and work is one of immense change that impacts physical activity attitudes and engagement in adulthood. The Stages of Change (SOC) model, which resides under the transtheoretical framework, has been proposed as one way to measure and evaluate physical activity uptake and maintenance. The current…

  10. Composites for Exploration Upper Stage (United States)

    Fikes, J. C.; Jackson, J. R.; Richardson, S. W.; Thomas, A. D.; Mann, T. O.; Miller, S. G.


    The Composites for Exploration Upper Stage (CEUS) was a 3-year, level III project within the Technology Demonstration Missions program of the NASA Space Technology Mission Directorate. Studies have shown that composites provide important programmatic enhancements, including reduced weight to increase capability and accelerated expansion of exploration and science mission objectives. The CEUS project was focused on technologies that best advanced innovation, infusion, and broad applications for the inclusion of composites on future large human-rated launch vehicles and spacecraft. The benefits included near- and far-term opportunities for infusion (NASA, industry/commercial, Department of Defense), demonstrated critical technologies and technically implementable evolvable innovations, and sustained Agency experience. The initial scope of the project was to advance technologies for large composite structures applicable to the Space Launch System (SLS) Exploration Upper Stage (EUS) by focusing on the affordability and technical performance of the EUS forward and aft skirts. The project was tasked to develop and demonstrate critical composite technologies with a focus on full-scale materials, design, manufacturing, and test using NASA in-house capabilities. This would have demonstrated a major advancement in confidence and matured the large-scale composite technology to a Technology Readiness Level 6. This project would, therefore, have bridged the gap for providing composite application to SLS upgrades, enabling future exploration missions.

  11. Turbine Stages with Heat Transfer

    Directory of Open Access Journals (Sweden)

    E. Y. K. Ng


    Full Text Available A better understanding of the flow inside the multi-stage turbomachines will be very useful to both the designer and operator. The numerical calculation for single blade row has been well established with the time marching computation of the Navier-Stokes equations. But there will exist much more difficulties for the multi-blade rows due to the rotor-stator interaction. The major problems are related to the unsteady flow which will inevitably exist in the blade passages due to the different rotating speed and possible the different in blade number. A method is presented for simulating various turbine blade rows in single-stage environment. A solver has been developed for studying the complex flow analysis of ‘proposed high pressure turbine’ (HPT using quasi-3-D Reynolds-averaged Navier-Stokes (Q3D RNS equations. The code achieves good quality solutions quickly even with relatively coarse mesh sizes. The work is first validated both with UTRC's and Zeschky and Gallus' subsonic turbine test cases covering inlet boundary conditions and Reynolds-averaged values. A H-type grid is adopted as it is easy to generate and can readily extend to 3D application. When rows are closely spaced, there can be a strong interaction which will impact the aerodynamic, thermal and structural performance of the blade.

  12. Eccentricity from transit photometry

    DEFF Research Database (Denmark)

    Van Eylen, Vincent; Albrecht, Simon


    and can be described by a Rayleigh distribution with $\\sigma$ = 0.049 $\\pm$ 0.013. This is in full agreement with solar system eccentricities, but in contrast to the eccentricity distributions previously derived for exoplanets from radial velocity studies. Our findings are helpful in identifying which...... (TTVs), and we present some previously unreported TTVs. Finally transit durations help distinguish between false positives and true planets and we use our measurements to confirm six new exoplanets....

  13. Women in Transition


    UNICEF Innocenti Research Centre. MONEE project


    The 1999 Central and Eastern Europe and Commonwealth of Independent States Regional Monitoring Report focuses on the experiences of girls and women during the transition, highlighting their role in regional progress and the obstacles they face. The Report covers a broad range of issues, including women’s participation in the emerging market economy and democratic governments, female access to health and education, trends in family formation and violence against women and girls. The Report cal...

  14. Monte Carlo transition probabilities


    Lucy, L. B.


    Transition probabilities governing the interaction of energy packets and matter are derived that allow Monte Carlo NLTE transfer codes to be constructed without simplifying the treatment of line formation. These probabilities are such that the Monte Carlo calculation asymptotically recovers the local emissivity of a gas in statistical equilibrium. Numerical experiments with one-point statistical equilibrium problems for Fe II and Hydrogen confirm this asymptotic behaviour. In addition, the re...

  15. A Continent in Transition

    Institute of Scientific and Technical Information of China (English)


    AFRICA has survived a year of great change.Most notable has been the transition affecting North Africa,where waves of protests resulted in regime changes in Libya,Tunisia,and Egypt.When the dust had settled,Libya's former leader Muammar Gaddafi lay dead in a storm water drain and Egypt's former leader Hosni Mubarrak lay frail and fearful on a bed in a courtroom,on trial for his life.

  16. Transitional justice and aid


    Hellsten, Sirkku K.


    This paper examines the current security-governance-development nexus, something that is often also discussed under the concept of transitional justice (TJ). The paper analyses how the ambiguous, evolving and expanding nature of the concept of TJ affects the planning, coordination, evaluation and assessment of aid given to conflict ridden, post-conflict or (post) authoritarian societies in order to strengthen their democracy. Special attention is paid to gender justice. Illustrations are draw...

  17. Stimulated coherent transition radiation

    Energy Technology Data Exchange (ETDEWEB)

    Hung-chi Lihn


    Coherent radiation emitted from a relativistic electron bunch consists of wavelengths longer than or comparable to the bunch length. The intensity of this radiation out-numbers that of its incoherent counterpart, which extends to wavelengths shorter than the bunch length, by a factor equal to the number of electrons in the bunch. In typical accelerators, this factor is about 8 to 11 orders of magnitude. The spectrum of the coherent radiation is determined by the Fourier transform of the electron bunch distribution and, therefore, contains information of the bunch distribution. Coherent transition radiation emitted from subpicosecond electron bunches at the Stanford SUNSHINE facility is observed in the far-infrared regime through a room-temperature pyroelectric bolometer and characterized through the electron bunch-length study. To measure the bunch length, a new frequency-resolved subpicosecond bunch-length measuring system is developed. This system uses a far-infrared Michelson interferometer to measure the spectrum of coherent transition radiation through optical autocorrelation with resolution far better than existing time-resolved methods. Hence, the radiation spectrum and the bunch length are deduced from the autocorrelation measurement. To study the stimulation of coherent transition radiation, a special cavity named BRAICER is invented. Far-infrared light pulses of coherent transition radiation emitted from electron bunches are delayed and circulated in the cavity to coincide with subsequent incoming electron bunches. This coincidence of light pulses with electron bunches enables the light to do work on electrons, and thus stimulates more radiated energy. The possibilities of extending the bunch-length measuring system to measure the three-dimensional bunch distribution and making the BRAICER cavity a broadband, high-intensity, coherent, far-infrared light source are also discussed.

  18. ATLAS Transitional Radiation Tracker

    CERN Multimedia

    ATLAS Outreach


    This colorful 3D animation is an excerpt from the film "ATLAS-Episode II, The Particles Strike Back." Shot with a bug's eye view of the inside of the detector. The viewer is taken on a tour of the inner workings of the transitional radiation tracker within the ATLAS detector. Subjects covered include what the tracker is used to measure, its structure, what happens when particles pass through the tracker, how it distinguishes between different types of particles within it.

  19. Nav Status & Daily Transit Report - (United States)

    Department of Transportation — Displays a breakdown of vessel transit through Eisenhower lock in Massena, NY by different types of vessels and comparing current year transits to the year previous....

  20. Effect of point defects and disorder on structural phase transitions

    Energy Technology Data Exchange (ETDEWEB)

    Toulouse, J.


    Since the beginning in 1986, the object of this project has been Structural Phase Transitions (SPT) in real as opposed to ideal materials. The first stage of the study has been centered around the role of Point Defects in SPT`s. Our intent was to use the previous knowledge we had acquired in the study of point defects in non-transforming insulators and apply it to the study of point defects in insulators undergoing phase transitions. In non-transforming insulators, point defects, in low concentrations, marginally affect the bulk properties of the host. It is nevertheless possible by resonance or relaxation methods to study the point defects themselves via their local motion. In transforming solids, however, close to a phase transition, atomic motions become correlated over very large distances; there, even point defects far removed from one another can undergo correlated motions which may strongly affect the transition behavior of the host. Near a structural transition, the elastic properties win be most strongly affected so as to either raise or decrease the transition temperature, prevent the transition from taking place altogether, or simply modify its nature and the microstructure or domain structure of the resulting phase. One of the well known practical examples is calcium-stabilized zirconia in which the high temperature cubic phase is stabilized at room temperature with greatly improved mechanical properties.

  1. A quantification model for apoptosis in mouse embryos in the early stage of fetation

    Institute of Scientific and Technical Information of China (English)


    Apoptosis is the most important inducement and modulator for embryos in the early stage of fetation, i.e. after the 8-cell stage, mostly the morula and blastula stage, to proceed to the stage of nonlinear development. Using a two-photon laser scanning microscopy (TPLSM) system, we obtained 3-dimensional (3D) fluorescent images of preimplantation mouse embryos. A model for quantification was established. The statistical results for the spatial location of apoptosis bodies in embryos was obtained following image processing, as well as investigation of the kinetics of apoptosis. It was found that most (70%) apoptosis occurred in the trophectoderm, and the departure between the centroid and geometric center of embryos had a step transition when embryos developed into the 32-cell stage, which was consistent with the theoretical prediction that the blastocele would induce a symmetry break of the distribution of cells in embryos.

  2. A quantification model for apoptosis in mouse embryos in the early stage of fetation

    Institute of Scientific and Technical Information of China (English)

    WANG PengFei; FU JianHua; MA WanYun; CHEN DieYan; Lü DanYu; BAI WenJia


    Apoptosis is the most important inducement and modulator for embryos in the early stage of fetation, i.e. after the 8-cell stage, mostly the morula and blastula stage, to proceed to the stage of nonlinear development. Using a two-photon laser scanning microscopy (TPLSM) system, we obtained 3-dimensional (3D) fluorescent images of preimplantation mouse embryos. A model for quantification was established. The statistical results for the spatial location of apoptosis bodies in embryos was obtained following image processing, as well as investigation of the kinetics of apoptosis. It was found that most (70%) apoptosis occurred in the trophectoderm, and the departure between the centroid and geometric center of embryos had a step transition when embryos developed into the 32-cell stage,which was consistent with the theoretical prediction that the blastocele would induce a symmetry break of the distribution of cells in embryos.

  3. Comparative Analysis of Sequence Characteristics among Different Superimposed Stages of the Chelif Basin, Algeria

    Institute of Scientific and Technical Information of China (English)

    ZHANG Yuanfu; JIANG Zaixing; WANG Yue; BAO Dandan


    Superimposed basins were investigated with respect to tectonic evolution, sediment deposition and petroleum characteristics within a single superposition stage generally. The comparative study was seldom seen. Sequence characteristics were compared for two different superimposed stages-an expanding rifting stage and a depression-foreland transition stage-in the Chelif Basin during the Miocene in this paper. A model and mechanism for sequence evolution of superimposed basins in different dynamic situations are discussed with respect to sequence similarities and differences. The compared characters include sequence thickness, sequence boundaries and system tracts, as well as sediment deposition within sequences and sequence development patterns. Finally, some typical features of sequence development concomitant with changes of superimposed stages in the Chelif Basin are discussed.

  4. An Analysis of Kohlberg's "Stage 4 1/2" within an Enhanced Framework of Moral Stages. (United States)

    Minnameier, Gerhard

    This paper discusses a well-known problem of stage categorization within Kohlberg's theory of moral stages (L. Kohlberg, 1973), that of "Stage 4 1/2." Some subjects previously scored at stage 4 in Kohlberg's framework took on some characteristics of stage 2 reasoning, which suggested the possibility of regression. To reconcile this…

  5. Transcriptional networks in epithelial-mesenchymal transition.

    Directory of Open Access Journals (Sweden)

    Christo Venkov

    Full Text Available Epithelial-mesenchymal transition (EMT changes polarized epithelial cells into migratory phenotypes associated with loss of cell-cell adhesion molecules and cytoskeletal rearrangements. This form of plasticity is seen in mesodermal development, fibroblast formation, and cancer metastasis.Here we identify prominent transcriptional networks active during three time points of this transitional process, as epithelial cells become fibroblasts. DNA microarray in cultured epithelia undergoing EMT, validated in vivo, were used to detect various patterns of gene expression. In particular, the promoter sequences of differentially expressed genes and their transcription factors were analyzed to identify potential binding sites and partners. The four most frequent cis-regulatory elements (CREs in up-regulated genes were SRY, FTS-1, Evi-1, and GC-Box, and RNA inhibition of the four transcription factors, Atf2, Klf10, Sox11, and SP1, most frequently binding these CREs, establish their importance in the initiation and propagation of EMT. Oligonucleotides that block the most frequent CREs restrain EMT at early and intermediate stages through apoptosis of the cells.Our results identify new transcriptional interactions with high frequency CREs that modulate the stability of cellular plasticity, and may serve as targets for modulating these transitional states in fibroblasts.

  6. Simplified Approach to Predicting Rough Surface Transition (United States)

    Boyle, Robert J.; Stripf, Matthias


    Turbine vane heat transfer predictions are given for smooth and rough vanes where the experimental data show transition moving forward on the vane as the surface roughness physical height increases. Consiste nt with smooth vane heat transfer, the transition moves forward for a fixed roughness height as the Reynolds number increases. Comparison s are presented with published experimental data. Some of the data ar e for a regular roughness geometry with a range of roughness heights, Reynolds numbers, and inlet turbulence intensities. The approach ta ken in this analysis is to treat the roughness in a statistical sense , consistent with what would be obtained from blades measured after e xposure to actual engine environments. An approach is given to determ ine the equivalent sand grain roughness from the statistics of the re gular geometry. This approach is guided by the experimental data. A roughness transition criterion is developed, and comparisons are made with experimental data over the entire range of experimental test co nditions. Additional comparisons are made with experimental heat tran sfer data, where the roughness geometries are both regular as well a s statistical. Using the developed analysis, heat transfer calculatio ns are presented for the second stage vane of a high pressure turbine at hypothetical engine conditions.

  7. Precision photometry for planetary transits

    CERN Document Server

    Pont, F; Pont, Frederic; Moutou, Claire


    We review the state of the art in follow-up photometry for planetary transit searches. Three topics are discussed: (1) Photometric monitoring of planets discovered by radial velocity to detect possible transits (2) Follow-up photometry of candidates from photometric transit searches to weed out eclipsing binaries and false positives (3) High-precision lightcurves of known transiting planets to increase the accuracy on the planet parameters.

  8. Searching for transit timing variations in transiting exoplanet systems

    CERN Document Server

    Hrudková, Marie; Benn, Chris; Pollacco, Don; Gibson, Neale; Joshi, Yogesh; Harmanec, Petr; Tulloch, Simon


    Searching for transit timing variations in the known transiting exoplanet systems can reveal the presence of other bodies in the system. Here we report such searches for two transiting exoplanet systems, TrES-1 and WASP-2. Their new transits were observed with the 4.2m William Herschel Telescope located on La Palma, Spain. In a continuing programme, three consecutive transits were observed for TrES-1, and one for WASP-2 during September 2007. We used the Markov Chain Monte Carlo simulations to derive transit times and their uncertainties. The resulting transit times are consistent with the most recent ephemerides and no conclusive proof of additional bodies in either system was found.

  9. Stages in the research process. (United States)

    Gelling, Leslie


    Research should be conducted in a systematic manner, allowing the researcher to progress from a general idea or clinical problem to scientifically rigorous research findings that enable new developments to improve clinical practice. Using a research process helps guide this process. This article is the first in a 26-part series on nursing research. It examines the process that is common to all research, and provides insights into ten different stages of this process: developing the research question, searching and evaluating the literature, selecting the research approach, selecting research methods, gaining access to the research site and data, pilot study, sampling and recruitment, data collection, data analysis, and dissemination of results and implementation of findings.

  10. The Nuclear Cryogenic Propulsion Stage (United States)

    Houts, Michael G.; Kim, Tony; Emrich, William J.; Hickman, Robert R.; Broadway, Jeramie W.; Gerrish, Harold P.; Doughty, Glen; Belvin, Anthony; Borowski, Stanley K.; Scott, John


    The fundamental capability of Nuclear Thermal Propulsion (NTP) is game changing for space exploration. A first generation Nuclear Cryogenic Propulsion Stage (NCPS) based on NTP could provide high thrust at a specific impulse above 900 s, roughly double that of state of the art chemical engines. Characteristics of fission and NTP indicate that useful first generation systems will provide a foundation for future systems with extremely high performance. The role of the NCPS in the development of advanced nuclear propulsion systems could be analogous to the role of the DC-3 in the development of advanced aviation. Progress made under the NCPS project could help enable both advanced NTP and advanced Nuclear Electric Propulsion (NEP). Nuclear propulsion can be affordable and viable compared to other propulsion systems and must overcome a biased public fear due to hyper-environmentalism and a false perception of radiation and explosion risk.

  11. Alameda-Contra Costa Transit District (AC Transit) Fuel Cell Transit Buses: Preliminary Evaluation Results

    Energy Technology Data Exchange (ETDEWEB)

    Chandler, K.; Eudy, L.


    This report provides an evaluation of three prototype fuel cell-powered transit buses operating at AC Transit in Oakland, California, and six baseline diesel buses similar in design to the fuel cell buses.


    Directory of Open Access Journals (Sweden)



    Full Text Available A 38-year-old female presented with a history of progressively enlarging abdominal mass. Abdominal computed tomography showed a pelvic mass involving both the ovaries and omentum. CA-125 was normal. Staging surgery was performed and the histopathological diagnosis of Transitional Cell Carcinoma was made and later confirmed by immuno-histochemistry. Transitional cell carcinoma of the ovary is a rare subtype of epithelial ovarian cancer. Surgical resection is the primary therapeutic approach, and patient’s outcomes after chemotherapy are better than for other types of ovarian cancers.

  13. [The demographic transition in Latin America and Europe]. (United States)

    Zavala De Cosio, M E


    This work describes and analyzes the "European model of demographic transition" and compares it to the fertility transition in Latin America, arguing that two different types of demographic transition coexist in Latin America. Chesnais has defined 3 principal postulates of the theory of demographic transition that he believes are universally valid: the precedence in time of mortality decline; the occurrence of reproductive transition in 2 phases, limitation of marriages followed by limitation of births; and the influence of economic growth on the initiation of the secular fertiilty decline. This work is largely limited to discussion of the first 2 postulates. In all the European transitions analyzed, mortality has declined before the occurrence of fertility changes. Exceptions cited in the literature have probably been caused by omissions or other problems in the data. The level of mortality at the beginning of the transition and the rate of decline differ, giving unique character to each transition. Imbalances resulting from mortality decline are at the root of modern fertility transitions. The French demographic transition was distinguished by early appearance of birth limitation by married couples, as part of the regulation of population growth. In the rest of Europe, during the pretransitional period, the traditional system of reproduction was regulated primarily by control of nuptiality. Only at a second stage was marital fertiity controlled, when limitation of marriage was no longer sufficient or had exceeded the limits of social acceptability. All countries of Northern and Western Europe recorded increased proportions definitively single as the demographic situation began to change, until the moment when couples began to limit births. The demographic transition in Latin America began at the end of the 19th century, with mortality decline. Fertility increased initially in Latin America as it had in Europe and for the same reasons, but the impact was greater

  14. Tumor Stage Mycosis Fungoides in a Child. (United States)

    Dulmage, Brittany O'Neill; Villaseñor-Park, Jennifer; Ho, Jonhan; Geskin, Larisa J; Grandinetti, Lisa M


    Mycosis fungoides is uncommon in children and most often presents as stage IA/IB. We present a case of stage IIB mycosis fungoides in a 13-year-old boy and discuss diagnostic examination and treatment considerations.

  15. Stage at diagnosis and ovarian cancer survival

    DEFF Research Database (Denmark)

    Maringe, Camille; Walters, Sarah; Butler, John;


    We investigate what role stage at diagnosis bears in international differences in ovarian cancer survival.......We investigate what role stage at diagnosis bears in international differences in ovarian cancer survival....

  16. Interconnected Levels of Multi-Stage Marketing

    DEFF Research Database (Denmark)

    Vedel, Mette; Geersbro, Jens; Ritter, Thomas


    must not only decide in general on the merits of multi-stage marketing for their firm, but must also decide on which level they will engage in multi-stage marketing. The triadic perspective enables a rich and multi-dimensional understanding of how different business relationships influence each other......Multi-stage marketing gains increasing attention as knowledge of and influence on the customer's customer become more critical for the firm's success. Despite this increasing managerial relevance, systematic approaches for analyzing multi-stage marketing are still missing. This paper conceptualizes...... different levels of multi-stage marketing and illustrates these stages with a case study. In addition, a triadic perspective is introduced as an analytical tool for multi-stage marketing research. The results from the case study indicate that multi-stage marketing exists on different levels. Thus, managers...

  17. Cyclin D and cdk4 Are Required for Normal Development beyond the Blastula Stage in Sea Urchin Embryos (United States)

    Moore, Jennifer C.; Sumerel, Jan L.; Schnackenberg, Bradley J.; Nichols, Jason A.; Wikramanayake, Athula; Wessel, Gary M.; Marzluff, William F.


    cdk4 mRNA and protein are constitutively expressed in sea urchin eggs and throughout embryonic development. In contrast, cyclin D mRNA is barely detectable in eggs and early embryos, when the cell cycles consist of alternating S and M phases. Cyclin D mRNA increases dramatically in embryos at the early blastula stage and remains at a constant level throughout embryogenesis. An increase in cdk4 kinase activity occurs concomitantly with the increase in cyclin D mRNA. Ectopic expression of cyclin D mRNA in eggs arrests development before the 16-cell stage and causes eventual embryonic death, suggesting that activation of cyclin D/cdk4 in cleavage cell cycles is lethal to the embryo. In contrast, blocking cyclin D or cdk4 expression with morpholino antisense oligonucleotides results in normal development of early gastrula-stage embryos but abnormal, asymmetric larvae. These results suggest that in sea urchins, cyclin D and cdk4 are required for normal development and perhaps the patterning of the developing embryo, but may not be directly involved in regulating entry into the cell cycle. PMID:12052892

  18. CT perfusion at early stage of hepatic diffuse disease

    Institute of Scientific and Technical Information of China (English)

    Sheng Guan; Wei-Dong Zhao; Kang-Rong Zhou; Wei-Jun Peng; Jian Mao; Feng Tang


    AIM: To determine the validity of the non-invasive method of CT perfusion (CTP) in rat model of hepatic diffuse disease. METHODS: Twenty-eight Wistar rats were divided into two groups. Liver diffuse lesions were induced by dietthylnitrosamine in 14 rats of test group. Rats in control groupwere bred with pure water. From the 1st to 12th wk after the test group was intervened, both groups were studied every week with CTP. CTP parameters of liver parenchymain different periods and pathologic changes in two groups were compared and analyzed.RESULTS: The process of hepatic diffuse lesions in test groups was dassified into three stages or periods according to the pathologic alterations, namely hepattitis, hepatic fibrosis, and cirrhosis. During this period, hepatic artery flow (HAF)of control group declined slightly, mean transit time (MTT),blood flow (BF) and volume (BV) increased, but there wereno significant differences between different periods. Tntest group, HAF tended to increase gradually, MTT prolonged obviously, BV and BF decreased at the same time. The results of statistical analysis revealed that the difference in the HAF ratio of test group to control group was significant.The ratio of BV and BF in test group to control group in stageof hepatitis and hepatic cirrhosis, hepatic fibrosis and early stage of hepatic cirrhosis was significantly different, but there was no significant difference between hepatitis and hepatic fibrosis. The main pathological changes in stage of hepatitis were swelling of hepatic cells, while sinusoid capillarization and deposition of collagen aggravated gradually in the extravascular Disse's spaces in stage of fibrosis and early stage of cirrhosis.CONCLUSION: The technique could reflect some early changes of hepatic blood perfusion in rat with liver diffuse disease and is valuable for their early diagnosis.

  19. The New Lung Cancer Staging System

    Institute of Scientific and Technical Information of China (English)

    Frank C. Detterbeck,MD, FCCP; Daniel J. Boffa, MD; Lynn T, Tanoue, MD, FCCP


    The International Association for the Study of Lung Cancer (IASLC) has conducted an extensive initiative to inform the revision of the lung cancer staging system. This involved development of an international database along with extensive analysis of a large population of patients and their prognoses. This article reviews the recommendations of the IASLC International Staging Committee for the definitions for the TNM descriptors and the stage grouping in the new non-small cell lung cancer staging system.

  20. Between Stage and Screen : Ingmar Bergman Directs



    Ingmar Bergman is worldwide known as a film and stage director. Yet no-one has attempted to compare his stage and screen activities. In Between stage and screen Egil Törnqvist examines formal and thematical correspondences and differences between a number of Bergman's stage, screen, and radio productions. In the prologue Bergman's spiritual and aesthetic heritage and his position in the twentieth century media landscape is outlined. In the epilogue the question is answered to what extent one ...

  1. Two Stage Gear Tooth Dynamics Program (United States)


    cordi - tions and associated iteration prooedure become more complex. This is due to both the increased number of components and to the time for a...solved for each stage in the two stage solution . There are (3 + ntrrber of planets) degrees of freedom fcr eacb stage plus two degrees of freedom...should be devised. It should be noted that this is not minor task. In general, each stage plus an input or output shaft will have 2 times (4 + number

  2. Risk Assessment on the Transition Program for Air Traffic Control Automation System Upgrade

    Directory of Open Access Journals (Sweden)

    Li Dong Bin


    Full Text Available We analyzed the safety risks of the transition program for Air Traffic Control (ATC automation system upgrade by using the event tree analysis method in this paper. We decomposed the occurrence progress of the three transition phase and built the event trees corresponding to the three stages, and then we determined the probability of success of each factor and calculated probability of success of the air traffic control automation system upgrade transition. In the conclusion, we illustrate the transition program safety risk according to the results.

  3. Mexico in Transition

    Directory of Open Access Journals (Sweden)

    Barbara Hogenboom


    Full Text Available – Mexico’s Politics and Society in Transition, edited by Joseph S. Tulchin and Andrew D. Selee. Boulder/London: Lynne Rienner Publishers, 2003. – México al inicio del siglo XXI: democracia, cuidadanía y desarrollo, edited by Alberto Aziz Nassif. México: CIESAS & Miguel Ángel Porrúa, 2003. – Globalización y alternativas incluyentes para el siglo XXI, edited by Jorge Basave, Alejandro Dabat, Carlos Morera, Miguel Ángel Rivera Ríos & Francisco Rodríguez. México: Instituto de Investigaciones Económica. UNAM & Miguel Ángel Porrúa, 2002.

  4. Wetting Transition in Water (United States)

    Friedman, S. R.; Khalil, M.; Taborek, P.


    Optical images were used to study the wetting behavior of water on graphite, sapphire, and quartz along the liquid vapor coexistence curve from room temperature to 300°C. Wetting transitions were identified by the temperature at which the contact angle decreased to zero and also by the disappearance of dropwise condensation. These two methods yielded consistent values for the wetting temperatures, which were 185°C, 234°C, and 271°C for water on quartz, sapphire, and graphite, respectively. We compare our results with the theoretical predictions based on a simplified model of the water-substrate potential and sharp interfaces.

  5. Transition Path Theory (United States)

    vanden-Eijnden, E.

    The dynamical behavior of many systems arising in physics, chemistry, biology, etc. is dominated by rare but important transition events between long lived states. For over 70 years, transition state theory (TST) has provided the main theoretical framework for the description of these events [17,33,34]. Yet, while TST and evolutions thereof based on the reactive flux formalism [1, 5] (see also [30,31]) give an accurate estimate of the transition rate of a reaction, at least in principle, the theory tells very little in terms of the mechanism of this reaction. Recent advances, such as transition path sampling (TPS) of Bolhuis, Chandler, Dellago, and Geissler [3, 7] or the action method of Elber [15, 16], may seem to go beyond TST in that respect: these techniques allow indeed to sample the ensemble of reactive trajectories, i.e. the trajectories by which the reaction occurs. And yet, the reactive trajectories may again be rather uninformative about the mechanism of the reaction. This may sound paradoxical at first: what more than actual reactive trajectories could one need to understand a reaction? The problem, however, is that the reactive trajectories by themselves give only a very indirect information about the statistical properties of these trajectories. This is similar to why statistical mechanics is not simply a footnote in books about classical mechanics. What is the probability density that a trajectory be at a given location in state-space conditional on it being reactive? What is the probability current of these reactive trajectories? What is their rate of appearance? These are the questions of interest and they are not easy to answer directly from the ensemble of reactive trajectories. The right framework to tackle these questions also goes beyond standard equilibrium statistical mechanics because of the nontrivial bias that the very definition of the reactive trajectories imply - they must be involved in a reaction. The aim of this chapter is to

  6. ALICE Transition Radiation Detector

    CERN Multimedia

    Pachmayer, Y


    The Transition Radiation Detector (TRD) is the main electron detector in ALICE. In conduction with the TPC and the ITS, it provides the necessary electron identification capability to study: - Production of light and heavy vector mesons as well as the continuum in the di-electron channel, - Semi leptonic decays of hadrons with open charm and open beauty via the single-electron channel using the displaced vertex information provided by the ITS, - Correlated DD and BB pairs via coincidences of electrons in the central barrel and muons in the forward muon arm, - Jets with high Pτ tracks in one single TRD stack.

  7. The backyard of transition

    Directory of Open Access Journals (Sweden)

    Đurić Jelena B.


    Full Text Available The reflection on the current period of transition in Serbian society indicates deep contradictions between the urge for European integration and the delay of institutional transformation that fuse with the indolence of a large part of the people. The crisis of values is conspicuous almost everywhere. Continuous changes have had hard consequences on Serbian society. During these changes moral patterns, values, spirituality were destroyed, rebuilt, and lost again. Hence, Serbian society now lies on the ruins of past 'traditions', general values, collective identities, and a common purpose. In everyday life, it is noticeable very often as, for example, in the Belgrade 'park-scape' whose photos obviously illustrate these problems.

  8. Understanding quantum phase transitions

    CERN Document Server

    Carr, Lincoln


    Quantum phase transitions (QPTs) offer wonderful examples of the radical macroscopic effects inherent in quantum physics: phase changes between different forms of matter driven by quantum rather than thermal fluctuations, typically at very low temperatures. QPTs provide new insight into outstanding problems such as high-temperature superconductivity and display fundamental aspects of quantum theory, such as strong correlations and entanglement. Over the last two decades, our understanding of QPTs has increased tremendously due to a plethora of experimental examples, powerful new numerical meth

  9. Real-Time History of the Cosmological Electroweak Phase Transition

    CERN Document Server

    Kurki-Suonio, H


    We study numerically the real-time history of the cosmological electrow= eak phase transition, as it may take place in the Standard Model or in MSSM f= or m_H < m_W according to recent lattice results. We follow the nucleated bubble= s from the initial stages of acceleration and rapid growth, through collisions w= ith compression waves resulting in slowing down and reheating to T_c, until t= he final stages of slow growth and evaporation. We find that collisions with compression waves may make the bubble walls oscillate in the radial direc= tion, and that reheating to T_c takes generically place.

  10. The Nuclear Cryogenic Propulsion Stage (United States)

    Houts, Michael G.; Kim, Tony; Emrich, William J.; Hickman, Robert R.; Broadway, Jeramie W.; Gerrish, Harold P.; Belvin, Anthony D.; Borowski, Stanley K.; Scott, John H.


    Nuclear Thermal Propulsion (NTP) development efforts in the United States have demonstrated the technical viability and performance potential of NTP systems. For example, Project Rover (1955 - 1973) completed 22 high power rocket reactor tests. Peak performances included operating at an average hydrogen exhaust temperature of 2550 K and a peak fuel power density of 5200 MW/m3 (Pewee test), operating at a thrust of 930 kN (Phoebus-2A test), and operating for 62.7 minutes in a single burn (NRX-A6 test). Results from Project Rover indicated that an NTP system with a high thrust-to-weight ratio and a specific impulse greater than 900 s would be feasible. Excellent results were also obtained by the former Soviet Union. Although historical programs had promising results, many factors would affect the development of a 21st century nuclear thermal rocket (NTR). Test facilities built in the US during Project Rover no longer exist. However, advances in analytical techniques, the ability to utilize or adapt existing facilities and infrastructure, and the ability to develop a limited number of new test facilities may enable affordable development, qualification, and utilization of a Nuclear Cryogenic Propulsion Stage (NCPS). Bead-loaded graphite fuel was utilized throughout the Rover/NERVA program, and coated graphite composite fuel (tested in the Nuclear Furnace) and cermet fuel both show potential for even higher performance than that demonstrated in the Rover/NERVA engine tests.. NASA's NCPS project was initiated in October, 2011, with the goal of assessing the affordability and viability of an NCPS. FY 2014 activities are focused on fabrication and test (non-nuclear) of both coated graphite composite fuel elements and cermet fuel elements. Additional activities include developing a pre-conceptual design of the NCPS stage and evaluating affordable strategies for NCPS development, qualification, and utilization. NCPS stage designs are focused on supporting human Mars

  11. Three stage semelparous Leslie models. (United States)

    Cushing, J M


    oscillations (not necessarily periodic) with separated life-cycle stages, while weak interactions promote stable equilibration with overlapping life-cycle stages. Methods used include the theory of planar monotone maps, average Lyapunov functions, and bifurcation theory techniques.

  12. Optimum Staging with Varying Thrust Attitude Angle

    Directory of Open Access Journals (Sweden)

    T. N. Srivastava


    Full Text Available Optimum staging programme for step rockets of arbitrary number of stages having different specific impulses and mass fractions with stages is derived, the optimization criterion being minimum take-off weight for a desired burntout velocity at an assigned altitude. Variation of thrust attitude angle from stage to stage and effects of gravity factor are taken into account. Analysis is performed for a degenerate problem obtained by relaxing the altitude constraint and it has been shown that problems of Weisbord, Subotowicz, Hall & Zambelli and Malina & Summerfield are the particular cases of the degenerate problem.

  13. Physicians in transition. (United States)

    Bluestein, P


    The study of physicians as managed care executives has been relatively recent. Much of what was written in the past focused primarily on doctors who had taken hospital-based administrative positions, especially as medical directors or vice presidents of medical affairs.1 But the '80s brought rising health care costs and the emergence of the "O's"--HMOs, PPOs, UROs, EPOs, PHOs, H2Os, and Uh-Ohs--in response. It also brought a growing number of physicians who traded their white coats and their particular "ologies" for the blue suits of executive management. I am convinced that it is important now, and will be increasingly important in the future, to better understand that transition. That belief led me to undertake, with the help and support of ACPE, the survey that is reported in this article. A questionnaire was sent in 1994 to a random sample of 300 managed care physician executive members of ACPE. Responses were returned by 225 members, a response rate of better than 80 percent. Twenty-five of the responses were not applicable, having been returned by physicians who had never made a transition from clinical careers. The remaining 230 responses form the basis for this report.

  14. Electroweak phase transitions

    CERN Document Server

    Fodor, Z


    Recent developments on the four dimensional (4d) lattice studies of the finite temperature electroweak phase transition (EWPT) are summarized. The phase diagram is given in the continuum limit. The finite temperature SU(2)-Higgs phase transition is of first order for Higgs-boson masses m/sub H/<66.5+or-1.4 GeV. Above this endpoint only a rapid cross-over can be seen. The full 4d result agrees completely with that of the dimensional reduction approximation. The Higgs-boson endpoint mass in the standard model (SM) would be 72.1+or-1. 4 GeV. Taking into account the LEP Higgs-boson mass lower bound excludes any EWPT in the SM. A one-loop calculation of the static potential in the SU(2)-Higgs model enables a precise comparison between lattice simulations and perturbative results. The most popular extension of the SM, the minimal supersymmetric SM (MSSM) is also studied on 4d lattices. (17 refs).

  15. Structural transition metal chemistry

    CERN Document Server

    Anderson, K M


    This thesis is divided up into five chapters as outlined below. Chapter 1 gives the background to the techniques used in this thesis including X-ray structure determination and ab initio methods. An overview of some recent studies using ab initio methods to study transition metal complexes is also given. Chapter 2 investigates structural trans influence in a number of transition metal and p-block complexes. The database and ab initio studies showed that the classical trans influence model based on Pt(II) chemistry does not always hold. For some systems (eg. d sup 1 sup 0 s sup 0 for Sb sup V and Sn sup I sup V) the cis influence is of similar magnitude to the trans influence. For other systems (d sup 0), the trans influence is not as powerful as usually assumed. Chapter 3 is an investigation into the bridging chloride unit. A database study was performed on three systems (M-CI-M', M-CI...H and M-CI...Li/Na/K). Reaction pathway analysis was carried out for the M-CI-M' case and showed that bond order is not con...

  16. Tiber Personal Rapid Transit

    Directory of Open Access Journals (Sweden)

    Diego Carlo D'agostino


    Full Text Available The project “Tiber Personal Rapid Transit” have been presented by the author at the Rome City Vision Competition1 2010, an ideas competition, which challenges architects, engineers, designers, students and creatives individuals to develop visionary urban proposals with the intention of stimulating and supporting the contemporary city, in this case Rome. The Tiber PRT proposal tries to answer the competition questions with the definition of a provocative idea: a Personal Rapid transit System on the Tiber river banks. The project is located in the central section of the Tiber river and aims at the renewal of the river banks with the insertion of a Personal Rapid Transit infrastructure. The project area include the riverbank of Tiber from Rome Transtevere RFI station to Piazza del Popolo, an area where main touristic and leisure attractions are located. The intervention area is actually no used by the city users and residents and constitute itself a strong barrier in the heart of the historic city.

  17. 76 FR 77302 - Federal Transit Administration (United States)


    ... Federal Transit Administration FY 2011 Discretionary Sustainability Funding Opportunity; Transit... Discretionary Bus and Bus Facilities Program AGENCY: Federal Transit Administration (FTA), DOT. ACTION: FTA...'s (DOT) Federal Transit Administration (FTA) announces the selection of Fiscal Year (FY)...

  18. Staging of portal hypertension and portosystemic shunts using dynamic nuclear medicine investigations (United States)

    Dragoteanu, Mircea; Balea, Ioan A; Dina, Liliana A; Piglesan, Cecilia D; Grigorescu, Ioana; Tamas, Stefan; Cotul, Sabin O


    AIM: To explore portal hypertension and portosystemic shunts and to stage chronic liver disease (CLD) based on the pathophysiology of portal hemodynamics. METHODS: Per-rectal portal scintigraphy (PRPS) was performed on 312 patients with CLD and liver angioscintigraphy (LAS) on 231 of them. The control group included 25 healthy subjects. We developed a new model of PRPS interpretation by introducing two new parameters, the liver transit time (LTT) and the circulation time between right heart and liver (RHLT). LTT for each lobe was used to evaluate the early portal hypertension. RHLT is useful in cirrhosis to detect liver areas missing portal inflow. We calculated the classical per-rectal portal shunt index (PRSI) at PRPS and the hepatic perfusion index (HPI) at LAS. RESULTS: The normal LTT value was 24 ± 1 s. Abnormal LTT had PPV = 100% for CLD. Twenty-seven non-cirrhotic patients had LTT increased up to 35 s (median 27 s). RHLT (42 ± 1 s) was not related to liver disease. Cirrhosis could be excluded in all patients with PRSI 30% had PPV = 100% for cirrhosis. Based on PRPS and LAS we propose the classification of CLD in 5 hemodynamic stages. Stage 0 is normal (LTT = 24 s, PRSI 30%. RHLT and HPI were used to subtype stage 4. In our study stage 0 had NPV = 100% for CLD, stage 1 had PPV = 100% for non-cirrhotic CLD, stages 2 and 3 represented the transition from chronic hepatitis to cirrhosis, stage 4 had PPV = 100% for cirrhosis. CONCLUSION: LTT allows the detection of early portal hypertension and of opening of transhepatic shunts. PRSI is useful in CLD with extrahepatic portosystemic shunts. Our hemodynamic model stages the evolution of portal hypertension and portosystemic shunts. It may be of use in the selection of patients for interferon therapy. PMID:18609707

  19. Local Reynolds number and thresholds of transition in shear flows (United States)

    Tao, JianJun; Chen, ShiYi; Su, WeiDong


    Recent experimental and numerical investigations reveal that the onset of turbulence in plane-Poiseuille flow and plane-Couette flow has some similar stages separated with different threshold Reynolds numbers. Based on these observations and the energy equation of a disturbed fluid element, a local Reynolds number Re L is derived to represent the maximum ratio of the energy supplement to the energy dissipation in a cross section. It is shown that along the sequence of transition stages, which include transient localized turbulence, "equilibrium" localized turbulence, spatially intermittent but temporally persistent turbulence and uniform turbulence, the corresponding thresholds of Re L for plane-Couette flow, Hagen-Poiseuille flow and plane-Poiseuille flow are consistent, indicating that the critical (threshold) states during the laminar-turbulent transition are determined by the local properties of the base flow and are independent of global features, such as flow geometries (pipe or channel) and types of driving forces (shear driving or pressure driving).

  20. Algebraic disturbances and their consequences in rotating channel flow transition

    CERN Document Server

    Jose, Sharath; Pier, Benoît; Govindarajan, Rama


    It is now established that subcritical mechanisms play a crucial role in the transition to turbulence of non-rotating plane shear flows. The role of these mechanisms in rotating channel flow is examined here in the linear and nonlinear stages. Distinct patterns of behaviour are found: the transient growth leading to nonlinearity at low rotation rates $Ro$, a highly chaotic intermediate $Ro$ regime, a localised weak chaos at higher $Ro$, and complete stabilization of transient disturbances at very high $Ro$. At very low $Ro$, the transient growth amplitudes are close to those for non-rotating flow, but Coriolis forces already assert themselves by producing distinct asymmetry about the channel centreline. Nonlinear processes are then triggered, in a streak-breakdown mode of transition. The high $Ro$ regimes do not show these signatures, here the leading eigenmode emerges as dominant in the early stages. Elongated structures plastered close to one wall are seen at higher rotation rates. Rotation is shown to redu...

  1. Complex Nonlinearity Chaos, Phase Transitions, Topology Change and Path Integrals

    CERN Document Server

    Ivancevic, Vladimir G


    Complex Nonlinearity: Chaos, Phase Transitions, Topology Change and Path Integrals is a book about prediction & control of general nonlinear and chaotic dynamics of high-dimensional complex systems of various physical and non-physical nature and their underpinning geometro-topological change. The book starts with a textbook-like expose on nonlinear dynamics, attractors and chaos, both temporal and spatio-temporal, including modern techniques of chaos–control. Chapter 2 turns to the edge of chaos, in the form of phase transitions (equilibrium and non-equilibrium, oscillatory, fractal and noise-induced), as well as the related field of synergetics. While the natural stage for linear dynamics comprises of flat, Euclidean geometry (with the corresponding calculation tools from linear algebra and analysis), the natural stage for nonlinear dynamics is curved, Riemannian geometry (with the corresponding tools from nonlinear, tensor algebra and analysis). The extreme nonlinearity – chaos – corresponds to th...

  2. Epidemiologic transition in an isolated indigenous community in the Valley of Oaxaca, Mexico. (United States)

    Malina, Robert M; Peña Reyes, Maria Eugenia; Little, Bertis B


    The objective of the present study is to analyze age-specific mortality in a rural indigenous community in the throes of a secular increase in size in the Valley of Oaxaca, southern Mexico, over 30 years, 1970-1999. Variation in mortality by age group was analyzed over time for evidence of an epidemiological transition. The seasonal rain pattern in the Valley of Oaxaca (83% from May through September) was evaluated for its relationship with mortality in wet and dry months. Mortality and causes of death changed markedly over the 30-year interval. Infant and preschool mortality, overall mortality, and causes of death changed from the 1970s through the 1990s. Prereproductive deaths (<15 years) predominated in the 1970s and were largely due to gastrointestinal and respiratory diseases, with periodic outbreaks of measles. Deaths of adults 65+ years predominated in the 1990s and were largely due to degenerative diseases usually associated with aging. The marked changes in age and causes of death over the three decades (epidemiologic transition from Stage I to Stage II) occurred concurrently with significant secular increases in body size in children, adolescents, and young adults, highlighting improved health and nutritional conditions in the community which is in early Stage II of the demographic transition. The demographic transition to Stage II is a leading indicator (15-25 years lag) for the onset of the secular trend, while the epidemiologic transition to Stage II is a predictor that the secular increase is in process in the study community.

  3. Freedom and the Ibsen Stage

    Institute of Scientific and Technical Information of China (English)

    Asbjφrn Aarseth


    To some extent Ibsen's career as a dramatist was conditioned by the physical limitations of the theatre buildings. He succeeded in turning these limitations to his advantage. Through dialogue and scenography he tried to achieve a longing in the audience to see the characters succeed in getting out of oppressive, prisonlike conditions. Gradually concentrating the action in the narrow room, he succeeded in achieving the effect of claustrophobia particularly in his work in the years 1877-86. After that he experimented in bringing the basic narrowness out in the open air scenography in 1888 with The Lady from the Sea. In Hedda Gabler and partly in John Gabriel Borkman he returned to the interior stage, but in the rest of the 1890s he preferred to situate some or most of the action in the open air. This selfimposed constriction is capable of producing an intense experience exactly because the urge to be free is amplified by the physical narrowness. Consequently it has proved difficult to make a successful movie on the basis of a modern prose play by Ibsen. The moving camera tends to dissolve the spatial limitations.

  4. Subcritical transition in plane Poiseuille flow as a linear instability process (United States)

    Roizner, Federico; Karp, Michael; Cohen, Jacob


    In this work, a transition scenario is demonstrated, in which most of the stages are followed analytically. The transition is initiated by the linear transient growth mechanism in plane Poiseuille flow subjected to an infinitesimally small secondary disturbance. A novel analytical approximation of the linear transient growth mechanism enables us to perform a secondary linear stability analysis of the modified base-flow. Two possible routes to transition are highlighted here, both correspond to a small secondary disturbance superimposed on a linear transient growth. The first scenario is initiated by four decaying odd normal modes which form a counter-rotating vortex pair; the second is initiated by five even decaying modes which form a pair of counter-rotating pairs. The approximation of the linear transient growth stage by a combination of minimal number of modes allows us to follow the transition stages analytically by employing the multiple time scale method. In particular, the secondary instability stage is followed analytically using linear tools, and is verified by obtaining transition in a direct numerical simulation initiated by conditions dictated by the transient growth analytical expressions. Very good agreement is observed, verifying the theoretical model. The similarities between the two transition routes are discussed and the results are compared with similar results obtained for plane Couette flow.

  5. Staging of moyamoya disease by perfusion SPECT

    Energy Technology Data Exchange (ETDEWEB)

    Kuwabara, Yasuo [Kyushu Univ., Fukuoka (Japan). Hospital; Matsushima, Toshio; Fukui, Masashi


    Staging of moyamoya disease, based on angiography and PET have already been established. The authors have established staging of moyamoya disease based on perfusion SPECT, that can be summarized as follows: Stage I, no abnormality is seen at rest or after acetazolamide loading; Stage II, no abnormality is seen at rest, however, a decreased response (blood flow increase rate: <15%) is seen to acetazolamide loading (a, a decreased response is seen only in the frontal lobe; b, a decreased response is seen in regions other than the frontal lobe; and c, a decreased response is seen throughout the cerebrum); Stage III, localized decrease in blood flow (blood flow decrease compared with peripheral tissue: {>=}15%) and marked decrease in response to acetazolamide (blood flow increase rate: <5%) are seen at rest. In Stage III, CT and MRI show no abnormal findings or only mild lesions of the white matter; and Stage IV, multiple decreases in blood flow are seen at rest, and CT and MRI reveal infarctions and severe atrophy at the same sites. The above staging does not require determination of cerebral blood flow, and thus it can be used in children, in whom cerebral blood flow determination is difficult. The authors performed 99m-Tc ECD perfusion SPECT in 25 patients with moyamoya disease for the staging, and compared staging based on angiography with staging based on perfusion SPECT. The results did not show a correlation between the 2 staging methods. A problem inherent in the staging of moyamoya disease based on perfusion SPECT is that the relationship between cerebral blood flow and cerebral radioactivity concentrations may differ depending on the drug used to determine cerebral blood flow. Thus, although the present staging system does not depend on any specific radioactive drug to determine cerebral blood flow, further investigation is necessary to identify a more appropriate drug than those in current use. (K.H.)

  6. The NETS Project: A NEtwork of transit surveys

    Directory of Open Access Journals (Sweden)

    Jiang I.-G.


    Full Text Available Motivated by the recent quick and successful development in the searching extrasolar planet (exoplanet by transit events, I started an instrumental project, the NETS Project, in 2006. In this paper, the background, goal, our design, the progress, and the current status will be reviewed. Although our research grant and manpower are limited, we are approaching to the stage to build up a station at an astronomical observatory.

  7. Economic development and the transition to democracy a formal model


    Baizhu Chen; Yi Feng


    In this essay, we have developed a rational choice model to study the transition to democracy. Such a model implies that the change or maintenance of a political system is the result of rational decisions by individuals, interest groups, and political parties under specific constraints. Our analysis shows that political systems are critically dependent upon the level of economic development. If a nation is at the lower stage of economic development, and, particularly, if its citizenry is poor...

  8. Two-stage crystallization of charged colloids under low supersaturation conditions. (United States)

    Kratzer, Kai; Arnold, Axel


    We report simulations on the homogeneous liquid-fcc nucleation of charged colloids for both low and high contact energy values. As a precursor for crystal formation, we observe increased local order at the position where the crystal will form, but no correlations with the local density. Thus, the nucleation is driven by order fluctuations rather than density fluctuations. Our results also show that the transition involves two stages in both cases, first a transition of liquid → bcc, followed by a bcc → hcp/fcc transition. Both transitions have to overcome free energy barriers, so that a spherical bcc-like cluster is formed first, in which the final fcc structure is nucleated mainly at the surface of the crystallite. This means that the second stage bcc-fcc phase transition is a heterogeneous nucleation in the partially grown solid phase, even though we start from a homogeneous bulk liquid. The height of the bcc → hcp/fcc free energy barrier strongly depends on the contact energies of the colloids. For low contact energy this barrier is low, so that the bcc → hcp/fcc transition occurs spontaneously. For the higher contact energy, the second barrier is too high to be crossed spontaneously by the colloidal system. However, it was possible to ratchet the system over the second barrier and to transform the bcc nuclei into the stable hcp/fcc phase. The transitions are dominated by the first liquid-bcc transition and can be described by classical nucleation theory using an effective surface tension.

  9. Pan1 regulates transitions between stages of clathrin-mediated endocytosis. (United States)

    Bradford, Mary Katherine; Whitworth, Karen; Wendland, Beverly


    Endocytosis is a well-conserved process by which cells invaginate small portions of the plasma membrane to create vesicles containing extracellular and transmembrane cargo proteins. Dozens of proteins and hundreds of specific binding interactions are needed to coordinate and regulate these events. Saccharomyces cerevisiae is a powerful model system with which to study clathrin-mediated endocytosis (CME). Pan1 is believed to be a scaffolding protein due to its interactions with numerous proteins that act throughout the endocytic process. Previous research characterized many Pan1 binding interactions, but due to Pan1's essential nature, the exact mechanisms of Pan1's function in endocytosis have been difficult to define. We created a novel Pan1-degron allele, Pan1-AID, in which Pan1 can be specifically and efficiently degraded in endocytosis and viability. The regions important for endocytosis and viability can be separated, suggesting that Pan1 may have a distinct role in the cell that is essential for viability.

  10. Modeling river dune development and dune transition to upper stage plane bed

    NARCIS (Netherlands)

    Naqshband, S.; Duin, van O.J.M.; Ribberink, J.S.; Hulscher, S.J.M.H.


    Large asymmetric bedforms known as dunes commonly dominate the bed of sand rivers. Due to the turbulence generation over their stoss and lee sides, dunes are of central importance in predicting hydraulic roughness and water levels. During floods in steep alluvial rivers, dunes are observed to grow r

  11. Survival after primary and deferred cystectomy for stage T1 transitional cell carcinoma of the bladder

    Directory of Open Access Journals (Sweden)

    Bedeir Ali-El-Dein


    Conclusions: Cancer-specific survival is statistically comparable for primary and deferred cystectomy in T1 bladder cancer, although there is a non-significant difference in favor of primary cystectomy. In the deferred cystectomy group, the number of TURBTs beyond three is associated with lower survival. Conservative treatment should be adopted for most cases in this category.

  12. Classification of brain disease in magnetic resonance images using two-stage local feature fusion (United States)

    Li, Tao; Li, Wu; Yang, Yehui


    Background Many classification methods have been proposed based on magnetic resonance images. Most methods rely on measures such as volume, the cerebral cortical thickness and grey matter density. These measures are susceptible to the performance of registration and limited in representation of anatomical structure. This paper proposes a two-stage local feature fusion method, in which deformable registration is not desired and anatomical information is represented from moderate scale. Methods Keypoints are firstly extracted from scale-space to represent anatomical structure. Then, two kinds of local features are calculated around the keypoints, one for correspondence and the other for representation. Scores are assigned for keypoints to quantify their effect in classification. The sum of scores for all effective keypoints is used to determine which group the test subject belongs to. Results We apply this method to magnetic resonance images of Alzheimer's disease and Parkinson's disease. The advantage of local feature in correspondence and representation contributes to the final classification. With the help of local feature (Scale Invariant Feature Transform, SIFT) in correspondence, the performance becomes better. Local feature (Histogram of Oriented Gradient, HOG) extracted from 16×16 cell block obtains better results compared with 4×4 and 8×8 cell block. Discussion This paper presents a method which combines the effect of SIFT descriptor in correspondence and the representation ability of HOG descriptor in anatomical structure. This method has the potential in distinguishing patients with brain disease from controls. PMID:28207873

  13. Acting Antarctica: science on stage (United States)

    Ciceri, Piera; Tizzoni, Paola; Pierro, Luigia


    Key-words: Polar science, Earth science, Theatre, Hands on activities The legendary Antarctic Expedition of sir E. Shackleton and his crew of 27 aboard the Endurance (1914/16) trapped in the Antarctic ice has become the starting point to learn about Polar Science and Climate Change. While the students were involved into this incredible adventure by the astonishing images of the Australian photographer Frank Hurley (who joined the crew), they discovered the world in which this story happened. Students were then involved in hands-on activities and role plays and have become the writers of the play "Uomini a scienza ai confini del mondo". They act the story of Shackelton's expedition and they tell at the same time to the audience about ice pack, ice cores and their role in understanding the past of the climate, physical and geographical characteristic of polar regions, thermal phenomena related to adaptations of polar animals, solar radiation at different latitude, day/night duration. The theater was the place to "stage" some scientific experiments and to explain the current research carried out in polar regions and their importance in climate change studies and to stress some similarities between Antarctica and space. The project was carried out from teachers of science, letters and geography and was born in collaboration with the "Piccolo Teatro di Milano" and the association "Science Under 18" with the support of a professional actor and director and was played for other schools at "EXPO 2015" in Milano (Italy). In our opinion drama activities improve reading comprehension, and both verbal and non-verbal communication skills. To be able to write and to act, students need a deep understanding of contents. Arts, including theatre, are a good key to involve emotionally students. To have an audience different from their own teachers and classmates offers a real task and the opportunity to play and let grow real skills.

  14. Invariant probabilities of transition functions

    CERN Document Server

    Zaharopol, Radu


    The structure of the set of all the invariant probabilities and the structure of various types of individual invariant probabilities of a transition function are two topics of significant interest in the theory of transition functions, and are studied in this book. The results obtained are useful in ergodic theory and the theory of dynamical systems, which, in turn, can be applied in various other areas (like number theory). They are illustrated using transition functions defined by flows, semiflows, and one-parameter convolution semigroups of probability measures. In this book, all results on transition probabilities that have been published by the author between 2004 and 2008 are extended to transition functions. The proofs of the results obtained are new. For transition functions that satisfy very general conditions the book describes an ergodic decomposition that provides relevant information on the structure of the corresponding set of invariant probabilities. Ergodic decomposition means a splitting of t...

  15. Learning phase transitions by confusion

    CERN Document Server

    van Nieuwenburg, Evert P L; Huber, Sebastian D


    Classifying phases of matter is a central problem in physics. For quantum mechanical systems, this task can be daunting owing to the exponentially large Hilbert space. Thanks to the available computing power and access to ever larger data sets, classification problems are now routinely solved using machine learning techniques. Here, we propose to use a neural network based approach to find phase transitions depending on the performance of the neural network after training it with deliberately incorrectly labelled data. We demonstrate the success of this method on the topological phase transition in the Kitaev chain, the thermal phase transition in the classical Ising model, and the many-body-localization transition in a disordered quantum spin chain. Our method does not depend on order parameters, knowledge of the topological content of the phases, or any other specifics of the transition at hand. It therefore paves the way to a generic tool to identify unexplored phase transitions.

  16. Strategic planning in transition

    DEFF Research Database (Denmark)

    Olesen, Kristian; Richardson, Tim


    In this paper, we analyse how contested transitions in planning rationalities and spatial logics have shaped the processes and outputs of recent episodes of Danish ‘strategic spatial planning’. The practice of ‘strategic spatial planning’ in Denmark has undergone a concerted reorientation...... in the recent years as a consequence of an emerging neoliberal agenda promoting a growth-oriented planning approach emphasising a new spatial logic of growth centres in the major cities and urban regions. The analysis, of the three planning episodes, at different subnational scales, highlights how this new...... style of ‘strategic spatial planning’ with its associated spatial logics is continuously challenged by a persistent regulatory, top-down rationality of ‘strategic spatial planning’, rooted in spatial Keynesianism, which has long characterised the Danish approach. The findings reveal the emergence...

  17. Transitive conformal holonomy groups

    CERN Document Server

    Alt, Jesse


    For $(M,[g])$ a conformal manifold of signature $(p,q)$ and dimension at least three, the conformal holonomy group $\\mathrm{Hol}(M,[g]) \\subset O(p+1,q+1)$ is an invariant induced by the canonical Cartan geometry of $(M,[g])$. We give a description of all possible connected conformal holonomy groups which act transitively on the M\\"obius sphere $S^{p,q}$, the homogeneous model space for conformal structures of signature $(p,q)$. The main part of this description is a list of all such groups which also act irreducibly on $\\R^{p+1,q+1}$. For the rest, we show that they must be compact and act decomposably on $\\R^{p+1,q+1}$, in particular, by known facts about conformal holonomy the conformal class $[g]$ must contain a metric which is locally isometric to a so-called special Einstein product.

  18. Transit spectroscopy with GTC

    Directory of Open Access Journals (Sweden)

    Osorio M.R. Zapatero


    Full Text Available Thanks to different ground-based surveys and space missions, nowadays we have a fairly large sample of discovered extra-solar planets to study and, without a doubt, this number will increase in the future. One of the most succesful techniques that allows us to prove the physical properties and atmospheric composition of these exoplanets is transmission spectroscopy. The level of precision that is require to measure these effects provides a technical challenge that is solved by using big telescopes and stable instruments to reach low noise levels. In this article, we will discuss the use of the 10m class telescope GTC to observed planetary transits in spectroscopic mode and some of the results that we are currently obtaining.

  19. Phases and Phase Transitions (United States)

    Gitterman, Moshe


    In discussing phase transitions, the first thing that we have to do is to define a phase. This is a concept from thermodynamics and statistical mechanics, where a phase is defined as a homogeneous system. As a simple example, let us consider instant coffee. This consists of coffee powder dissolved in water, and after stirring it we have a homogeneous mixture, i.e., a single phase. If we add to a cup of coffee a spoonful of sugar and stir it well, we still have a single phase -- sweet coffee. However, if we add ten spoonfuls of sugar, then the contents of the cup will no longer be homogeneous, but rather a mixture of two homogeneous systems or phases, sweet liquid coffee on top and coffee-flavored wet sugar at the bottom...

  20. Nonadiabatic transition path sampling (United States)

    Sherman, M. C.; Corcelli, S. A.


    Fewest-switches surface hopping (FSSH) is combined with transition path sampling (TPS) to produce a new method called nonadiabatic path sampling (NAPS). The NAPS method is validated on a model electron transfer system coupled to a Langevin bath. Numerically exact rate constants are computed using the reactive flux (RF) method over a broad range of solvent frictions that span from the energy diffusion (low friction) regime to the spatial diffusion (high friction) regime. The NAPS method is shown to quantitatively reproduce the RF benchmark rate constants over the full range of solvent friction. Integrating FSSH within the TPS framework expands the applicability of both approaches and creates a new method that will be helpful in determining detailed mechanisms for nonadiabatic reactions in the condensed-phase.

  1. The Geometric Transition Revisited

    CERN Document Server

    Gwyn, Rhiannon


    Our intention in this article is to review known facts and to summarise recent advances in the understanding of geometric transitions and the underlying open/closed duality in string theory. We aim to present a pedagogical discussion of the gauge theory underlying the Klebanov--Strassler model and review the Gopakumar--Vafa conjecture based on topological string theory. These models are also compared in the T-dual brane constructions. We then summarise a series of papers verifying both models on the supergravity level. An appendix provides extensive background material about conifold geometries. We pay special attention to their complex structures and re-evaluate the supersymmetry conditions on the background flux in constructions with fractional D3-branes on the singular (Klebanov--Strassler) and resolved (Pando Zayas--Tseytlin) conifolds. We agree with earlier results that only the singular solution allows a supersymmetric flux, but point out the importance of using the correct complex structure to reach th...

  2. Transitions in Secondary Education

    DEFF Research Database (Denmark)

    Larsen, Britt Østergaard; Jensen, Leif; Pilegaard Jensen, Torben


    The purpose of this article is to investigate educational choices and attainment of children who experience social problems during their upbringing. The study explores the extent to which social problems can help explain the gaps in entry and dropout rates in upper secondary education in Denmark...... between students from different socioeconomic backgrounds. Population-based registers are used to include information on family upbringing, e.g. alcohol abuse, criminality, use of psychopharmaca and out-of-home placement. We estimate a parsimonious version of Cameron and Heckman's (2001) dynamic...... statistical model of educational progression. By using this method, we parcel educational attainment into a series of transitions and the model is able to control for educational selection and unobserved heterogeneity. We apply counterfactual analyses to allow a formal decomposition of the effects of social...

  3. Electroweak phase transition in technicolor

    CERN Document Server

    Jarvinen, Matti


    Several phenomenologically viable walking technicolor models have been proposed recently. I demonstrate that these models can have first order electroweak phase transitions, which are sufficiently strong for electroweak baryogenesis. Strong dynamics can also lead to several separate transitions at the electroweak scale, with the possibility of a temporary restoration and an extra breaking of the electroweak symmetry. First order phase transitions will produce gravitational waves, which may be detectable at future experiments.

  4. Transition Complexity of Incomplete DFAs

    Directory of Open Access Journals (Sweden)

    Yuan Gao


    Full Text Available In this paper, we consider the transition complexity of regular languages based on the incomplete deterministic finite automata. A number of results on Boolean operations have been obtained. It is shown that the transition complexity results for union and complementation are very different from the state complexity results for the same operations. However, for intersection, the transition complexity result is similar to that of state complexity.

  5. Aspects of Transition in Turbomachines (United States)

    Hodson, H. P.


    This talk provides a description of several types of transition encountered in turbomachines. It is based largely on personal experience of the detection of transition in turbomachines. Examples are taken from axial compressors, axial turbines and radial turbines. The illustrations are concerned with transition in steady and unsteady boundary layers that develop under the influence of two-dimensional and three-dimensional flow fields.

  6. Transition in hypersonic boundary layers

    Directory of Open Access Journals (Sweden)

    Chuanhong Zhang


    Full Text Available Transition and turbulence production in a hypersonic boundary layer is investigated in a Mach 6 wind tunnel using Rayleigh-scattering visualization, fast-response pressure measurements, and particle image velocimetry. It is found that the second-mode instability is a key modulator of the transition process. Although the second-mode is primarily an acoustic wave, it causes the formation of high-frequency vortical waves, which triggers a fast transition to turbulence.

  7. DNS Study on Physics of Late Boundary Layer Transition

    CERN Document Server

    Liu, Chaoqun


    This paper serves as a review of our recent new DNS study on physics of late boundary layer transition. This includes mechanism of the large coherent vortex structure formation, small length scale generation and flow randomization. The widely spread concept vortex breakdown to turbulence,which was considered as the last stage of flow transition, is not observed and is found theoretically incorrect. The classical theory on boundary layer transition is challenged and we proposed a new theory with five steps, i.e. receptivity, linear instability, large vortex formation, small length scale generation, loss of symmetry and randomization to turbulence. We have also proposed a new theory about turbulence generation. The new theory shows that all small length scales (turbulence) are generated by shear layer instability which is produced by large vortex structure with multiple level vortex rings, multiple level sweeps and ejections, and multiple level negative and positive spikes near the laminar sub-layers.Therefore,...

  8. Precursor of transition to turbulence: spatiotemporal wave front. (United States)

    Bhaumik, S; Sengupta, T K


    To understand transition to turbulence via 3D disturbance growth, we report here results obtained from the solution of Navier-Stokes equation (NSE) to reproduce experimental results obtained by minimizing background disturbances and imposing deterministic excitation inside the shear layer. A similar approach was adopted in Sengupta and Bhaumik [Phys. Rev. Lett. 107, 154501 (2011)], where a route of transition from receptivity to fully developed turbulent stage was explained for 2D flow in terms of the spatio-temporal wave-front (STWF). The STWF was identified as the unit process of 2D turbulence creation for low amplitude wall excitation. Theoretical prediction of STWF for boundary layer was established earlier in Sengupta, Rao, and Venkatasubbaiah [Phys. Rev. Lett. 96, 224504 (2006)] from the Orr-Sommerfeld equation as due to spatiotemporal instability. Here, the same unit process of the STWF during transition is shown to be present for 3D disturbance field from the solution of governing NSE.

  9. Arguing on entropic and enthalpic first-order phase transitions in strongly interacting matter

    CERN Document Server

    Wunderlich, Falk; Kampfer, Burkhard


    The pattern of isentropes in the vicinity of a first-order phase transition is proposed as a key for a sub-classification. While the confinement--deconfinement transition, conjectured to set in beyond a critical end point in the QCD phase diagram, is often related to an entropic transition and the apparently settled gas-liquid transition in nuclear matter is an enthalphic transition, the conceivable local isentropes w.r.t.\\ "incoming" or "outgoing" serve as another useful guide for discussing possible implications, both in the presumed hydrodynamical expansion stage of heavy-ion collisions and the core-collapse of supernova explosions. Examples, such as the quark-meson model and two-phase models, are shown to distinguish concisely the different transitions.

  10. What do we know about the timing of fertility transitions in Europe? (United States)

    Guinnane, T W; Okun, B S; Trussell, J


    The Princeton project on the decline of fertility in Europe (the European Fertility Project) suggested that this historical fertility transition occurred virtually simultaneously in a wide variety of economic and social environments. This finding has been cited widely as evidence for an innovation/diffusion view of fertility transitions. We demonstrate that the demographic methods used to date the fertility transition in Europe--primarily Ig, and (to a lesser extent) the Coale-Trussell M&m indices--may fail to detect the initial stages of a fertility transition and therefore cannot be used as the basis for strong statements about the timing of transitions. We review these measurement problems and their implications for the current understanding of the European fertility transition.

  11. Probabilistic excitation of plasma transitions

    Energy Technology Data Exchange (ETDEWEB)

    Itoh, Sanae; Toda, Shinichiro; Yagi, Masatoshi [Kyushu Univ., Kasuga, Fukuoka (Japan). Research Inst. for Applied Mechanics; Itoh, Kimitaka; Fukuyama, Atsushi


    Statistical property of an excitation of plasma transition is analyzed, which takes place in a strongly turbulent state. Transition characteristics which have been studied in a deterministic picture are re-examined. Model equations of transition, with a hysteresis nature in flux-gradient relation in the presence of strong self-noise, are solved and the dynamics of plasma gradient and turbulent-driven flux is studied. The excitation probability is shown to be fairly large well below the conventional critical condition. Probability distribution function, as a function of the gradient, for an onset of the transition is obtained both for power law noise. (author)

  12. Transition Metal Compounds Towards Holography

    Directory of Open Access Journals (Sweden)

    Volker Dieckmann


    Full Text Available We have successfully proposed the application of transition metal compounds in holographic recording media. Such compounds feature an ultra-fast light-induced linkage isomerization of the transition-metal–ligand bond with switching times in the sub-picosecond regime and lifetimes from microseconds up to hours at room temperature. This article highlights the photofunctionality of two of the most promising transition metal compounds and the photophysical mechanisms that are underlying the hologram recording. We present the latest progress with respect to the key measures of holographic media assembled from transition metal compounds, the molecular embedding in a dielectric matrix and their impressive potential for modern holographic applications.

  13. Optical transitions in semiconductor nanostructures

    Energy Technology Data Exchange (ETDEWEB)

    Rupasov, Valery I. [ALTAIR Center LLC, Shrewsbury, MA 01545 (United States) and Landau Institute for Theoretical Physics, Moscow (Russian Federation)]. E-mail:


    Employing the Maxwell equations and conventional boundary conditions for the radiation field on the nanostructure interfaces, we compute the radiative spontaneous decay rate of optical transitions in spherical semiconductor nanocrystals, core-shell nanocrystals and nanostructures comprising more than one shell. We also show that the coupling between optical transitions localized in the shell of core-shell nanocrystals and radiation field is determined by both conventional electro-multipole momenta and electro-multipole 'inverse' momenta. The latter are proportional to the core radius even for interband transitions that should result in very strong optical transitions.

  14. Structural Transition in Supercritical Fluids

    Directory of Open Access Journals (Sweden)

    Boris I. Sedunov


    Full Text Available The extension of the saturation curve ( on the PT diagram in the supercritical region for a number of monocomponent supercritical fluids by peak values for different thermophysical properties, such as heat capacities and and compressibility has been studied. These peaks signal about some sort of fluid structural transition in the supercritical region. Different methods give similar but progressively diverging curves st( for this transition. The zone of temperatures and pressures near these curves can be named as the zone of the fluid structural transition. The outstanding properties of supercritical fluids in this zone help to understand the physical sense of the fluid structural transition.

  15. Diverse types of percolation transitions (United States)

    Lee, Deokjae; Cho, Y. S.; Kahng, B.


    Percolation has long served as a model for diverse phenomena and systems. The percolation transition, that is, the formation of a giant cluster on a macroscopic scale, is known as one of the most robust continuous transitions. Recently, however, many abrupt percolation transitions have been observed in complex systems. To illustrate such phenomena, considerable effort has been made to introduce models and construct theoretical frameworks for explosive, discontinuous, and hybrid percolation transitions. Experimental results have also been reported. In this review article, we describe such percolation models, their critical behaviors and universal features, and real-world phenomena.

  16. Diverse types of percolation transitions

    CERN Document Server

    Lee, Deokjae; Kahng, Byungnam


    Percolation has long served as a model for diverse phenomena and systems. The percolation transition, that is, the formation of a giant cluster on a macroscopic scale, is known as one of the most robust continuous transitions. Recently, however, many abrupt percolation transitions have been observed in complex systems. To illustrate such phenomena, considerable effort has been made to introduce models and construct theoretical frameworks for explosive, discontinuous, and hybrid percolation transitions. Experimental results have also been reported. In this review article, we describe such percolation models, their critical behaviors and universal features, and real-world phenomena.

  17. Transition to management -- A personal perspective

    Energy Technology Data Exchange (ETDEWEB)

    Williams, J.L.


    This paper explores one woman`s journey through her recent promotion into management, and will identify key factors that helped prepare and position her to be ready to exercise leadership through a formal management role. It discusses assessment of qualifications and skills, acquisition of needed skills, the influence of luck and timing, and the use of mentors and delegation as survival skills to get through the transition period and become fully functional as a manager. It also includes insights into sensitive issues such as how to relate to former peers, how to gain credibility as the junior member of the management team, and how to juggle family responsibilities with increased time commitments at work. It emphasizes the importance of acknowledging the help the authors receive in reaching their own career goals and offering the same kind of help and support to those in the early stages of their careers.

  18. Staging of portal hypertension and portosystemic shunts using dynamic nuclear medicine investigations

    Institute of Scientific and Technical Information of China (English)

    Mircea Dragoteanu; Ioan A Balea; Liliana A Dina; Cecilia D Piglesan; Ioana Grigorescu; Stefan Tamas; Sabin O Cotul


    AIM: To explore portal hypertension and portosystemic shunts and to stage chronic liver disease (CLD)based on the pathophysiology of portal hemodynamics.METHODS: Per-rectal portal scintigraphy (PRPS) was performed on 312 patients with CLD and liver angioscintigraphy (LAS) on 231 of them.The control group included 25 healthy subjects.We developed a new model of PRPS interpretation by introducing two new parameters,the liver transit time (LIT) and the circulation time between right heart and liver (RHLT).LTT for each lobe was used to evaluate the early portal hypertension.RHLT is useful in cirrhosis to detect liver areas missing portal inflow.We calculated the classical per-rectal portal shunt index (PRSI) at PRPS and the hepatic perfusion index (HPI) at LAS.RESULTS: The normal LTT value was 24 ±1 s.Abnormal LTT had PPV = 100% for CLD.Twenty-seven noncirrhotic patients had L-IT increased up to 35 s (median 27 s).RHLT (42 ±1 s) was not related to liver disease.Cirrhosis could be excluded in all patients with PRSI< 5% (P < 0.01).PRSI > 30% had PPV = 100% for cirrhosis.Based on PRPS and LAS we propose the classification of CLD in 5 hemodynamic stages.Stage 0 is normal (LIT = 24 s,PRSI < 5%).In stage 1,LIT is increased,while PRSI remains normal.In stage 2,LIT is decreased between 16 s and 23 s,whereas PRSI is increased between 5% and 10%.In stage 3,PRSI is increased to 10%-30%,and LTT becomes undetectable by PRPS due to the portosystemic shunts.Stage 4 includes the patients with PRSI > 30%.RHLT and HPI were used to subtype stage 4.In our study stage 0 had NPV = 100% for CLD,stage 1 had PPV = 100% for non-cirrhotic CLD,stages 2 and 3 represented the transition from chronic hepatitis to cirrhosis,stage 4 had PPV = 100% for cirrhosis.CONCLUSION: LTT allows the detection of early portal hypertension and of opening of transhepatic shunts.PRSI is useful in CLD with extrahepatic portosystemic shunts.Our hemodynamic model stages the evolution of portal hypertension

  19. Innovation policy for the Dutch energy transition Operationalising transition management?

    NARCIS (Netherlands)

    D.A. Loorbach (Derk); R. Kemp (René)


    textabstractThe term transition is a key term of the fourth national environmental policy plan (NMP4, 2001), which put forward transition management (Rotmans et al, 2000) as a new policy approach for dealing with persistent and highly complex societal problems such as climate change, loss of biodive

  20. Life in Transition

    DEFF Research Database (Denmark)

    Overgaard, Dorthe; Grufstedt Kjeldgaard, Heidi; Egerod, Ingrid


    BACKGROUND:: A left ventricular assist device (LVAD) is used as a bridge to transplantation in patients with acute heart failure. The device is a major bodily invasion that challenges everyday life. Only few studies have explored the psychosocial adjustments of patients living with an LVAD....... OBJECTIVE:: The aim of this study was to explore the lived experience of patients with LVAD. METHODS:: The present study had a qualitative explorative design using in-depth interviews of 10 adult patients that had experienced life with an LVAD from 2008 to 2010 in Denmark. We constructed an interview guide...... with themes relating to the chronology of the illness trajectory. Data were managed by the qualitative computer package NVivo 8. As a theoretical framework, we chose a life-stage model for the main theme: Life With LVAD. The model describes the developmental tasks in each age group, and we looked...

  1. Compact 6-DOF Stage for Optical Adjustments (United States)

    Shafaat, Syed; Chang, Daniel


    The figure depicts selected aspects of a six-degree-of-freedom (6-DOF) stage for mechanical adjustment of an optical component. The six degrees of freedom are translations along the Cartesian axes (x, y, and z) and rotations about these axes (theta x, theta y, and theta z, respectively). Relative to prior such stages, this stage offers advantages of compactness, stability, and robustness, plus other advantages as described below. The stage was designed specifically as part of a laser velocimeter and altimeter in which light reflected by a distant object is collected by a Cassegrainian telescope and focused into a single-mode, polarization-maintaining optical fiber. The stage is used to position and orient the input end of the optical fiber with respect to the focal point of the telescope. Stages like this one can also be adapted for use in positioning and orienting other optical components, including lenses, prisms, apertures, and photodetectors.

  2. Experience Transitioning Models and Data at the NOAA Space Weather Prediction Center (United States)

    Berger, Thomas


    The NOAA Space Weather Prediction Center has a long history of transitioning research data and models into operations and with the validation activities required. The first stage in this process involves demonstrating that the capability has sufficient value to customers to justify the cost needed to transition it and to run it continuously and reliably in operations. Once the overall value is demonstrated, a substantial effort is then required to develop the operational software from the research codes. The next stage is to implement and test the software and product generation on the operational computers. Finally, effort must be devoted to establishing long-term measures of performance, maintaining the software, and working with forecasters, customers, and researchers to improve over time the operational capabilities. This multi-stage process of identifying, transitioning, and improving operational space weather capabilities will be discussed using recent examples. Plans for future activities will also be described.

  3. Light Scattering in Exoplanet Transits (United States)

    Robinson, Tyler D.; Fortney, Jonathan J.


    Transit spectroscopy is currently the leading technique for studying exoplanet atmospheric composition, and has led to the detection of molecular species, clouds, and/or hazes for numerous worlds outside the Solar System. The field of exoplanet transit spectroscopy will be revolutionized with the anticipated launch of NASA's James Webb Space Telescope (JWST) in 2018. Over the course of the design five year mission for JWST, the observatory is expected to provide in-depth observations of many tens of transiting exoplanets, including some worlds in the poorly understood 2-4 Earth-mass regime. As the quality of transit spectrum observations continues to improve, so should models of exoplanet transits. Thus, certain processes initially thought to be of second-order importance should be revisited and possibly added to modeling tools. For example, atmospheric refraction, which was commonly omitted from early transit spectrum models, has recently been shown to be of critical importance in some terrestrial exoplanet transits. Beyond refraction, another process that has seen little study with regards to exoplanet transits is light multiple scattering. In most cases, scattering opacity in exoplanet transits has been treated as equivalent to absorption opacity. However, this equivalence cannot always hold, such as in the case of a strongly forward scattering, weakly absorbing aerosol. In this presentation, we outline a theory of exoplanet transit spectroscopy that spans the geometric limit (used in most modern models) to a fully multiple scattering approach. We discuss a new technique for improving model efficiency that effectively separates photon paths, which tend to vary slowly in wavelength, from photon absorption, which can vary rapidly in wavelength. Using this newly developed approach, we explore situations where cloud or haze scattering may be important to JWST observations of gas giants, and comment on the conditions necessary for scattering to become a major

  4. Experiments for Multi-Stage Processes

    DEFF Research Database (Denmark)

    Tyssedal, John; Kulahci, Murat


    Multi-stage processes are very common in both process and manufacturing industries. In this article we present a methodology for designing experiments for multi-stage processes. Typically in these situations the design is expected to involve many factors from different stages. To minimize...... the required number of experimental runs, we suggest using mirror image pairs of experiments at each stage following the first. As the design criterion, we consider their projectivity and mainly focus on projectivity 3 designs. We provide the methodology for generating these designs for processes with any...

  5. 携带SEA和CD80双基因的重组腺病毒转染B16细胞体外诱导T淋巴细胞活化的研究%Study on T lymphocyte activation induced by B16 cell after infection with the recombinant adenovirus carrying SEA and CD80 gene in vitro

    Institute of Scientific and Technical Information of China (English)

    司少艳; 刘俊丽; 徐冰心; 化楠; 秦亚亚; 刘昌叶; 宋淑军


    Objective:To observe whether Staphylococcus enterotoxin A( SEA)and CD80 expressing on the surface of B16 cells could induce immune response after infection with recombinant adenoviruses. Methods:Mouse spleen lymphocytes were cocultured with B16 cells after infection with empty adenoviruse vector Ad( empty)or the recombi-nant adenoviruses of Ad-MMRE-mTERT-B7,Ad-MMRE-mTERT-SEA or Ad-MMRE-mTERT-BIS. Then,lymphocyte proliferation was assayed by BrdU incorporation using a commercial kit,flow cytometric analysis was used to detect proliferation of T lymphocyte subgroups. The production of IL-2,TNF-α and IFN-γ was tested by enzyme-linked immunosorbent assay. Results:Compared with B16 infected with empty adenovirus or without infec-tion,B16 infected with recombinant adenoviruses could significantly induce proliferation of spleen lymphocytes and T lymphocyte subgroups,and increase IL-2,TNF-αand IFN-γproduction. The antitumor response was significantly stronger in B16 cells after dual-gene expression than that in B16 cells after single-gene expression. Conclusion:The results indicate that SEA and CD80 expressed on the membrane of B16 cells after infection with recombinant ade-novirus has immune activities. This study provides some experimental evidence for further immune genetherapy against malignant melanoma with the recombinant adenovirus.%目的:观察恶性黑色素瘤B16细胞经重组腺病毒感染后,表达在B16细胞膜上的SEA和CD80体外能否诱导免疫学反应。方法:B16细胞分别经空载体腺病毒Ad(空)和重组腺病毒Ad-MMRE-mTERT-B7、Ad-MMRE-mTERT-SEA、Ad-MMRE -mTERT-BIS感染后,和小鼠脾淋巴细胞共培养,然后,采用Brdu 酶联免疫法( ELISA)检测淋巴细胞增殖;流式细胞术检测T淋巴细胞亚群增殖;ELISA法检测细胞因子IL-2、TNF-α和IFN-γ的产生。结果:与感染空载体腺病毒Ad(空)和未感染B16细胞相比,经重组腺病毒感染的B16细胞体外能够显著

  6. New graduate nurses in transition

    DEFF Research Database (Denmark)

    Tingleff, Ellen Boldrup; Gildberg, Frederik Alkier


    Research on experiences of transition into mental health-care roles seems sparse, but it is vital in order to produce a comprehensive understanding of the transition into mental health-care roles and to serve as a foundation for future research and development. The aim of the present study was to...

  7. Homological Type of Geometric Transitions

    CERN Document Server

    Rossi, Michele


    The present paper gives an account and quantifies the change in topology induced by small and type II geometric transitions, by introducing the notion of the \\emph{homological type} of a geometric transition. The obtained results agree with, and go further than, most results and estimates, given to date by several authors, both in mathematical and physical literature.

  8. Transition management: origin, evolution, critique

    NARCIS (Netherlands)

    J. Rotmans (Jan); D.A. Loorbach (Derk); R. Kemp (René)


    textabstractTransition management has rapidly emerged over the past few years as a new approach to dealing with complex societal problems and governance in the context of these problems. In the Netherland, UK and Belgium, serious efforts have been and are being undertaken to develop transition polic

  9. Water drives peptide conformational transitions

    CERN Document Server

    Nerukh, Dmitry


    Transitions between metastable conformations of a dipeptide are investigated using classical molecular dynamics simulation with explicit water molecules. The distribution of the surrounding water at different moments before the transitions and the dynamical correlations of water with the peptide's configurational motions indicate that water is the main driving force of the conformational changes.

  10. The written language in the final stage of preschool education

    Directory of Open Access Journals (Sweden)

    Maria Helena Martins da Cruz Horta


    Full Text Available The main objective of this qualitative study, which adopted a multiple case study approach, is to learn about the process of methodology of the written language in the final stage of preschool education, in kindergartens located in Eastern Algarve and belonging to the public network of the Ministry of Education. The study shows that the way in which the approach to written language in preschool education takes place is the result of a set of variables of diverse nature: the management curriculum developed; the perspective that each protagonist has of the written language (a form of expression and communication; their attitude vis-à-vis early conceptions about the written language of children (an attitude of support and stimulation; the assurance offered to children so that they can feel confident about their knowledge and learning in the transition to the next educational level, making them believe that they are capable of achieving it.

  11. Properties of a two stage adiabatic demagnetization refrigerator (United States)

    Fukuda, H.; Ueda, S.; Arai, R.; Li, J.; Saito, A. T.; Nakagome, H.; Numazawa, T.


    Currently, many space missions using cryogenic temperatures are being planned. In particular, high resolution sensors such as Transition Edge Sensors need very low temperatures, below 100 mK. It is well known that the adiabatic demagnetization refrigerator (ADR) is one of most useful tools for producing ultra-low temperatures in space because it is gravity independent. We studied a continuous ADR system consisting of 4 stages and demonstrated it could provide continuous temperatures around 100 mK. However, there was some heat leakage from the power leads which resulted in reduced cooling power. Our efforts to upgrade our ADR system are presented. We show the effect of using the HTS power leads and discuss a cascaded Carnot cycle consisting of 2 ADR units.

  12. Bayesian priors for transiting planets

    CERN Document Server

    Kipping, David M


    As astronomers push towards discovering ever-smaller transiting planets, it is increasingly common to deal with low signal-to-noise ratio (SNR) events, where the choice of priors plays an influential role in Bayesian inference. In the analysis of exoplanet data, the selection of priors is often treated as a nuisance, with observers typically defaulting to uninformative distributions. Such treatments miss a key strength of the Bayesian framework, especially in the low SNR regime, where even weak a priori information is valuable. When estimating the parameters of a low-SNR transit, two key pieces of information are known: (i) the planet has the correct geometric alignment to transit and (ii) the transit event exhibits sufficient signal-to-noise to have been detected. These represent two forms of observational bias. Accordingly, when fitting transits, the model parameter priors should not follow the intrinsic distributions of said terms, but rather those of both the intrinsic distributions and the observational ...

  13. México: elected transition

    Directory of Open Access Journals (Sweden)

    Mauricio MERINO HUERTA


    Full Text Available The results of the Mexican federal elections of July 2000 raised new questions for those interested in transitions. In contrast to the South American, East-European, and South European experiences –that have produced a rich literature on the subject–, political changes in Mexico are not easily placed within the existing theoretical frameworks. This paper aims at contrasting the ideal model of transition and the real Mexican transition. The argument focuses on three differences: instead of a transition based on pact –as suggested by theory– this has been a transition based on voting. Moreover, there has not been –as in other cases— a breaking point with the previous regime, but a gradual and continuous opening. Finally, rather than a transformation of the rules of the game, what has taken place is a recovery of formal institutions, not the design of new ones.

  14. Transitive Reduction of Citation Networks

    CERN Document Server

    Clough, James R; Loach, Tamar V; Evans, Tim S


    Citation networks form directed acyclic graphs. The transitive reduction of such a DAG removes all edges in the graph that are implied by transitivity, but retains the causal structure of the original network. We investigate how the degree distribution, clustering coefficients and relationship between time of publication and degree (representing citation count) are changed under transitive reduction. We show that models which accurately reproduce the degree distribution of a citation network before transitive reduction may not do so afterwards and hence suggest that these models fail to accurately capture the causal structure of the network. We also investigate how the citation count of individual papers is changed and suggest that information about the types of citations a paper receives can be inferred from the number of citations which are retained after transitive reduction. These methods are tested on citation networks from the hep-th and hep-ph sections of the arXiv repository, and all data has been mad...

  15. Narratives about labour market transitions

    DEFF Research Database (Denmark)

    Cort, Pia; Thomsen, Rie


    on flexicurity and its implications for labour market transitions, little attention has been paid to the views and experiences of the individuals concerned. The aim of this article is to connect the grand narrative with individual narratives about labour market transitions in the Danish flexicurity system....... On the basis of narrative interviews with skilled workers, this article explores how labour market transitions are experienced by the individual and the role played by national support structures in the individual narratives. The article shows how, for the individual, a transition may prove to be a valuable...... learning experience during which radical career decisions are taken, and how support structures may work to the detriment of such learning and of the principles behind flexicurity. The article points to a reconceptualisation of transitions as important learning opportunities during which (more) adequate...

  16. Multiobjective Optimization and Phase Transitions

    CERN Document Server

    Seoane, Luís F


    Many complex systems obey to optimality conditions that are usually not simple. Conflicting traits often interact making a Multi Objective Optimization (MOO) approach necessary. Recent MOO research on complex systems report about the Pareto front (optimal designs implementing the best trade-off) in a qualitative manner. Meanwhile, research on traditional Simple Objective Optimization (SOO) often finds phase transitions and critical points. We summarize a robust framework that accounts for phase transitions located through SOO techniques and indicates what MOO features resolutely lead to phase transitions. These appear determined by the shape of the Pareto front, which at the same time is deeply related to the thermodynamic Gibbs surface. Indeed, thermodynamics can be written as an MOO from where its phase transitions can be parsimoniously derived; suggesting that the similarities between transitions in MOO-SOO and Statistical Mechanics go beyond mere coincidence.

  17. Non-equilibrium phase transitions

    CERN Document Server

    Henkel, Malte; Lübeck, Sven


    This book describes two main classes of non-equilibrium phase-transitions: (a) static and dynamics of transitions into an absorbing state, and (b) dynamical scaling in far-from-equilibrium relaxation behaviour and ageing. The first volume begins with an introductory chapter which recalls the main concepts of phase-transitions, set for the convenience of the reader in an equilibrium context. The extension to non-equilibrium systems is made by using directed percolation as the main paradigm of absorbing phase transitions and in view of the richness of the known results an entire chapter is devoted to it, including a discussion of recent experimental results. Scaling theories and a large set of both numerical and analytical methods for the study of non-equilibrium phase transitions are thoroughly discussed. The techniques used for directed percolation are then extended to other universality classes and many important results on model parameters are provided for easy reference.

  18. Study of blade aspect ratio on a compressor front stage aerodynamic and mechanical design report (United States)

    Burger, G. D.; Lee, D.; Snow, D. W.


    A single stage compressor was designed with the intent of demonstrating that, for a tip speed and hub-tip ratio typical of an advanced core compressor front stage, the use of low aspect ratio can permit high levels of blade loading to be achieved at an acceptable level of efficiency. The design pressure ratio is 1.8 at an adiabatic efficiency of 88.5 percent. Both rotor and stator have multiple-circular-arc airfoil sections. Variable IGV and stator vanes permit low speed matching adjustments. The design incorporates an inlet duct representative of an engine transition duct between fan and high pressure compressor.

  19. One-stage and two-stage penile buccal mucosa urethroplasty

    Directory of Open Access Journals (Sweden)

    G. Barbagli


    Full Text Available The paper provides the reader with the detailed description of current techniques of one-stage and two-stage penile buccal mucosa urethroplasty. The paper provides the reader with the preoperative patient evaluation paying attention to the use of diagnostic tools. The one-stage penile urethroplasty using buccal mucosa graft with the application of glue is preliminary showed and discussed. Two-stage penile urethroplasty is then reported. A detailed description of first-stage urethroplasty according Johanson technique is reported. A second-stage urethroplasty using buccal mucosa graft and glue is presented. Finally postoperative course and follow-up are addressed.

  20. Transitions in Theory and Practice: Managing Metals in the Circular Economy

    Directory of Open Access Journals (Sweden)

    Melissa Jackson


    Full Text Available Transitioning from current resource management practice dominated by linear economic models of consumption and production, to circular models of resource use, will require insights into the stages and processes associated with socio-technical transitions. This paper is concerned with transitions in practice. It explores two frameworks within the transitions literature—the multi-level perspective and transition management theory—for practical guidance to inform a deliberate transition in practice. The critical futures literature is proposed as a source of tools and methods to be used in conjunction with the transition frameworks to influence and enable transitions in practice. This enhanced practical guidance for initiating action is applied to a specific context—transitioning the Australian metals sector towards a circular economy model. This particular transition case study is relevant because the vision of a circular economy model of resource management is gaining traction internationally, Australia is significant globally as a supplier of finite mineral resources and it will also be used in a collaborative research project on Wealth from Waste to investigate possibilities for the circular economy and metals recycling.

  1. Danish mothers' perception of healthiness of their dietary behaviors during transition to parenthood

    DEFF Research Database (Denmark)

    Aschemann-Witzel, Jessica


    analyzed by content analysis. Three stages within the transition are identified. Pregnancy and birth can be perceived as separate turning points in women’s dietary behaviors. In addition, the child joining the family table affects parental diets. Factors of major influence in the three stages were......Becoming a parent is regarded as a crucial event in the life course, inducing changes in dietary behaviors. However, little is known about how the healthiness of diets and eating habits is influenced during this transition. Qualitative problem-centered interviews with 15 Danish mothers were...

  2. Stages of Small-Group Development Revisited (United States)

    Tuckman, Bruce W.; Jensen, Mary Ann C.


    This review examines published research on small-group development done in the last ten years that would constitute an empirical test of Tuckman's hypothesis that groups go through the stages of "forming,""storming,""norming," and "performing." A fifth stage, "adjourning," was added to the…

  3. Transesophageal Ultrasonography for Lung Cancer Staging

    DEFF Research Database (Denmark)

    Konge, Lars; Annema, Jouke; Vilmann, Peter


    Accurate mediastinal nodal staging is essential for patients with resectable non-small-cell lung cancer and is achieved by combined endobronchial ultrasound and transesophageal endoscopic ultrasound (EUS). Training requirements for EUS-guided fine-needle aspiration (FNA) for lung cancer staging...

  4. Dislocation generation during early stage sintering. (United States)

    Sheehan, J. E.; Lenel, F. V.; Ansell, G. S.


    Discussion of the effects of capillarity-induced stresses on dislocations during early stage sintering. A special version of Hirth's (1963) theoretical calculation procedures modified to describe dislocation nucleation on planes meeting the sintering body's neck surface obliquely is shown to predict plastic flow at stress levels know to exist between micron size metal particles in the early stages of sintering.

  5. The Sixth Stage of Moral Development (United States)

    Morelli, E. A.


    This assessment of L. Kohlberg's theory of moral development is a dialectical critique focusing on his claim that the sixth stage of moral development is morally adequate, specifically, that it is both comprehensive and fully equilibrated. Includes a brief account of B. J. Lonergan's dialectical method and an analysis of the sixth stage of…

  6. Second-Stage Music Teachers' Professional Identities (United States)

    Draves, Tami J.


    The purpose of this case study research was to explore the professional identities of second-stage music teachers, or those in years 4-10 of teaching, focusing primarily on how their identities were sustained or neglected. Participants were two second stage music educators teaching in middle school (grades 6-8) music classrooms and taught…

  7. Indeterminate Pulmonary Nodules at Colorectal Cancer Staging

    DEFF Research Database (Denmark)

    Nordholm-Carstensen, Andreas; Wille-Jørgensen, Peer A; Jorgensen, Lars N


    This study aimed to estimate the prevalence of indeterminate pulmonary nodules and specific radiological and clinical characteristics that predict malignancy of these at initial staging chest computed tomography (CT) in patients with colorectal cancer. A considerable number of indeterminate...... pulmonary nodules, which cannot readily be classified as either benign or malignant, are detected at initial staging chest CT in colorectal cancer patients....

  8. [Klatskin tumors: rational diagnostics and staging]. (United States)

    Denzer, U W; Rösch, T


    Klatskin tumors continue to be a challenge for diagnostic assessment and staging due to their longitudinal tumor growth along the perihilar bile ducts. Therefore the rate of non-resectable tumors remains relatively stable despite modern imaging and endoscopic techniques. This article reviews the current diagnostic methods for preoperative staging and the significance for predicting resectability.

  9. Developmental Stages in the Conceptualization of Marriage (United States)

    Tamashiro, Roy T.


    "Marriage" is treated as a mental concept that evolves in a developmental sequence of four qualitatively distinct stages: Magical, Idealized Conventional, Individualistic, and Affirmational. Each stage is illustrated with excerpts from Ingmar Bergman's Scenes From a Marriage. Some applications for marriage counselors are suggested. (Author)

  10. The Stages of Mailed Questionnaire Returning Behavior. (United States)

    Lockhart, Daniel C.


    Six stages are hypothesized that define the behavior of returning mailed questionnaires: receiving the questionnaire, opening the mail, forming an overall impression, answering the questions, returning the questionnaire, and dealing with nonrespondents. The researcher must provide incentives at each stage if potential respondents are to complete a…

  11. A Remarkable Recent Transition in the Solar Dynamo (United States)

    de Jager, C.; Akasofu, S.-I.; Duhau, S.; Livingston, W. C.; Nieuwenhuijzen, H.; Potgieter, M. S.


    We summarize the major aspects of the remarkable, fairly long lasting period ( ˜ 2005 to ˜ 2010) of low solar activity, that we will call the Transition. It is the transitional stage between the Grand Maximum of the 20th century and a forthcoming (most probably Regular) episode of solar activity. The various kinds of activity in the functioning of the equatorial components of the solar dynamo before and during the Transition are summarized. While the behavior of unipolar magnetic regions and their rest-latitudes already gave very early indications - mid 20th century - of the forthcoming Transition, more such indications became available around 1995 and the main part of it occurred between 2005 and 2010. Some of the inferences are discussed. We submit the hypothesis that the solar tachocline undergoes pulsations and we present some helioseismic evidences. In that scenario we find that its equatorial part has moved downward over a fairly small semi-amplitude ( ˜ 0.03 solar radii) during the time of the Transition. There are several indications, apart from this `pulsation', that the tachocline may even be pulsating with still smaller amplitudes in more modes. We speculate about the physical mechanism(s).

  12. Minnowbrook II 1997 Workshop on Boundary Layer Transition in Turbomachines (United States)

    LaGraff John E. (Editor); Ashpis, David E. (Editor)


    The volume contains materials presented at the Minnowbrook II - 1997 Workshop on Boundary Layer Transition in Turbomachines, held at Syracuse University Minnowbrook Conference Center, New York, on September 7-10, 1997. The workshop followed the informal format at the 1993 Minnowbrook I workshop, focusing on improving the understanding of late stage (final breakdown) boundary layer transition, with the engineering application of improving design codes for turbomachinery in mind. Among the physical mechanisms discussed were hydrodynamic instabilities, laminar to turbulent transition, bypass transition, turbulent spots, wake interaction with boundary layers, calmed regions, and separation, all in the context of flow in turbomachinery, particularly in compressors and high and low pressure turbines. Results from experiments, DNS, computation, modeling and theoretical analysis were presented. Abstracts and copies of viewgraphs, a specifically commissioned summation paper prepared after the workshop, and a transcript of the extensive working group reports and discussions are included in this volume. They provide recommendations for future research and clearly highlight the need for continued vigorous research in the technologically important area of transition in turbomachines.

  13. 22 CFR 41.71 - Transit aliens. (United States)


    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Transit aliens. 41.71 Section 41.71 Foreign... NATIONALITY ACT, AS AMENDED Transit Aliens § 41.71 Transit aliens. (a) Transit aliens—general. An alien is classifiable as a nonimmigrant transit alien under INA 101(a) (15) (C) if the consular officer is...

  14. Uniformly convex-transitive function spaces


    Rambla-Barreno, Fernando; Talponen, Jarno


    We introduce a property of Banach spaces called uniform convex-transitivity, which falls between almost transitivity and convex-transitivity. We will provide examples of uniformly convex-transitive spaces. This property behaves nicely in connection with some Banach-valued function spaces. As a consequence, we obtain new examples of convex-transitive Banach spaces.

  15. Democratic transition and foreign direct investment: Transition process matters


    Derbali, Ahmed; Trabelsi Masmoudi, Lilia; Zitouna, Habib


    This paper provides evidence on the relationship between foreign direct investment (FDI) and democratic transition. We propose first an econometric analysis of the determinants of the democratization process through a "probit" model. We consider a sample of 173 countries, with 44 that have experienced a democratic transition over the period 1980-2010. Our results reveal that variables related to human development and individual freedom facilitate the initiation of the democratic process in co...

  16. Novel Techniques with the Aid of a Staged CBCT Guided Surgical Protocol


    Evdokia Chasioti; Mohammed Sayed; Howard Drew


    The case report will present some novel techniques for using a “staged” protocol utilizing strategic periodontally involved teeth as transitional abutments in combination with CBCT guided implant surgery. Staging the case prevented premature loading of the grafted sites during the healing phase. A CBCT following a tenting screw guided bone regeneration procedure ensured adequate bone to place an implant fixture. Proper assessment of the CBCT allowed the surgeon to do an osteotome internal sin...

  17. Analysis of unique beta transitions

    DEFF Research Database (Denmark)

    Eman, B.; Krmpotic, F.; Tadic, D;


    The Heidelberg group measurements [For abstr. see Phys. Rev. Nucl. Sci. Vol. 15 (1965)] of unique forbidden transitions have been analysed. It has been found that experimental shape factors can be reproduced only with the induced pseudoscalar form factor d ...-non-conserving tensor form factor b > 0. In the former case they contradict Daniel's results [See abstr. 1966A10720] for 0- rarr 0+ transitions, whereas in the latter they are in disagreement with other known analyses of mu-meson capture, allowed and forbidden transitions. The conclusion appears to be independent...

  18. Magnetic resonance of phase transitions

    CERN Document Server

    Owens, Frank J; Farach, Horacio A


    Magnetic Resonance of Phase Transitions shows how the effects of phase transitions are manifested in the magnetic resonance data. The book discusses the basic concepts of structural phase and magnetic resonance; various types of magnetic resonances and their underlying principles; and the radiofrequency methods of nuclear magnetic resonance. The text also describes quadrupole methods; the microwave technique of electron spin resonance; and the Mössbauer effect. Phase transitions in various systems such as fluids, liquid crystals, and crystals, including paramagnets and ferroelectrics, are also

  19. Controlled quantum evolutions and transitions

    Energy Technology Data Exchange (ETDEWEB)

    Petroni, Nicola Cufaro [INFN Sezione di Bari, INFM Unitadi Bari and Dipartimento Interateneo di Fisica dell' Universitae del Politecnico di Bari, Bari (Italy); De Martino, Salvatore; De Siena, Silvio; Illuminati, Fabrizio [INFM Unitadi Salerno, INFN Sezione di Napoli - Gruppo collegato di Salerno and Dipartimento di Fisica dell' Universitadi Salerno, Baronissi, Salerno (Italy)


    We study the nonstationary solutions of Fokker-Planck equations associated to either stationary or non stationary quantum states. In particular, we discuss the stationary states of quantum systems with singular velocity fields. We introduce a technique that allows arbitrary evolutions ruled by these equations to account for controlled quantum transitions. As a first significant application we present a detailed treatment of the transition probabilities and of the controlling time-dependent potentials associated to the transitions between the stationary, the coherent, and the squeezed states of the harmonic oscillator. (author)

  20. Controlled quantum evolutions and transitions

    CERN Document Server

    Petroni, N C; De Siena, S; Illuminati, F


    We study the nonstationary solutions of Fokker-Planck equations associated to either stationary or nonstationary quantum states. In particular we discuss the stationary states of quantum systems with singular velocity fields. We introduce a technique that allows to realize arbitrary evolutions ruled by these equations, to account for controlled quantum transitions. The method is illustrated by presenting the detailed treatment of the transition probabilities and of the controlling time-dependent potentials associated to the transitions between the stationary, the coherent, and the squeezed states of the harmonic oscillator. Possible extensions to anharmonic systems and mixed states are briefly discussed and assessed.


    Institute of Scientific and Technical Information of China (English)

    Li Lingfeng; Tan Jianrong; Chen Yuanpeng


    Metaball-based constraint deformation technique is used to change the definition of r, the straight-line distance from a space point to a constraint center in the original calculation of the potential function. By replacing the parameter of the parametrized surface w with the straight-line distance r, a method of building transition surfaces according to connected boundary curves and skeleton curves is proposed. The method has no restrictions on boundary curves that control the space shapes of transition surfaces or on types of skeleton curves, thus transition surfaces, which reach C1 continuity and are more abundant in shapes and natural, can be obtained.

  2. Tools for Reactive Distillation Column Design: Graphical and Stage-to-Stage Computation Methods

    DEFF Research Database (Denmark)

    Sanchez Daza, O.; Cisneros, Eduardo Salvador P.; Hostrup, Martin


    Based on the element mass balance concept, a graphical design method and a stage-to-stage multicomponent design method for reactive distillation columns have been developed. For distillation columns comprising reactive and non-reactive stages, a simple design strategy based on reactive and non-re...

  3. Transition to turbulence in pipe flow as a phase transition (United States)

    Vasudevan, Mukund; Hof, Björn


    In pipe flow, turbulence first arises in the form of localized turbulent patches called puffs. The flow undergoes a transition to sustained turbulence via spatio-temporal intermittency, with puffs splitting, decaying and merging in the background laminar flow. However, the due to mean advection of the puffs and the long timescales involved (~107 advective time units), it is not possible to study the transition in typical laboratory set-ups. So far, it has only been possible to indirectly estimate the critical point for the transition. Here, we exploit the stochastic memoryless nature of the puff decay and splitting processes to construct a pipe flow set-up, that is periodic in a statistical sense. It then becomes possible to study the flow for sufficiently long times and characterize the transition in detail. We present measurements of the turbulent fraction as a function of Reynolds number which in turn allows a direct estimate of the critical point. We present evidence that the transition has features of a phase transition of second order.

  4. Multi-Stage Programs are Generalized Arrows

    CERN Document Server

    Megacz, Adam


    The lambda calculus, subject to typing restrictions, provides a syn- tax for the internal language of cartesian closed categories. This paper establishes a parallel result: staging annotations, subject to named level restrictions, provide a syntax for the internal language of Freyd categories, which are known to be in one-to-one correspondence with Arrows. The connection is made by interpreting multi-stage type systems as indexed functors from polynomial categories to their reindexings (Definitions 15 and 16). This result applies only to multi-stage languages which are (1) homogeneous, (2) allow cross-stage persistence and (3) place no restrictions on the use of structural rules in typing derivations. Removing these restrictions and repeating the construction yields generalized arrows, of which Arrows are a particular case. A translation from well-typed multi-stage programs to single-stage GArrow terms is provided. The translation is defined by induction on the structure of the proof that the multi-stage prog...

  5. Empowering Students in Transition (United States)

    Sullivan, Ann-Catherine


    The purpose of this study was to (a) identify potential benefits for students with disabilities taking part in a physical activity program with same-age typical peers on a Midwest university campus and (b) to determine if the program impacted the students with disabilities empowerment. Empowerment theory was used to determine how transition students’ attitudes change over the course of the semester while participating in a workout buddy program with same-age college peers. The program was structured to provide a sense of empowerment to students to make their own decisions and learn for themselves so they do not feel a lack of power in their lives. This study implemented elements of a quantitative design but a majority utilized a qualitative design based on the assumptions of the Interpretivist paradigm. The quantitative design elements focused on the analysis of two questionnaires: Sports Questionnaire and the Perceived Control Scale Questionnaire. The analysis of the focus group data revealed the following themes as positive effects of the intervention: positive effect on empowerment, how happy the program made the students, what benefits the students gained from the program, the student’s familiarity with university students, and the environment, and, lastly, the students ability to ask for assistance when need. Findings from the study determined that the empowerment of the students with disabilities was impacted while participating in the program. In general, the findings of gaining empowerment were similar to previous studies in that students with disabilities are able to gain empowerment from participation in fitness and recreation programs. The researcher noted during focus groups that some of the Best of Both Worlds (BOBW) students were not confident in starting conversations with their university peers. Although the BOBW students felt a sense of losing empowerment with this specific instance, there was an overall positive impact on the BOBW students

  6. Hybrid percolation transition in complex networks (United States)

    Kahng, Byungnam

    Percolation has been one of the most applied statistical models. Percolation transition is one of the most robust continuous transitions known thus far. However, recent extensive researches reveal that it exhibits diverse types of phase transitions such as discontinuous and hybrid phase transitions. Here hybrid phase transition means the phase transition exhibiting natures of both continuous and discontinuous phase transitions simultaneously. Examples include k-core percolation, cascading failures in interdependent networks, synchronization, etc. Thus far, it is not manifest if the critical behavior of hybrid percolation transitions conforms to the conventional scaling laws of second-order phase transition. Here, we investigate the critical behaviors of hybrid percolation transitions in the cascading failure model in inter-dependent networks and the restricted Erdos-Renyi model. We find that the critical behaviors of the hybrid percolation transitions contain some features that cannot be described by the conventional theory of second-order percolation transitions.

  7. Lymph node staging in prostate cancer. (United States)

    Sankineni, Sandeep; Brown, Anna M; Fascelli, Michele; Law, Yan Mee; Pinto, Peter A; Choyke, Peter L; Turkbey, Baris


    Nodal staging is important in prostate cancer treatment. While surgical lymph node dissection is the classic method of determining whether lymph nodes harbor malignancy, this is a very invasive technique. Current noninvasive approaches to identifying malignant lymph nodes are limited. Conventional imaging methods rely on size and morphology of lymph nodes and have notoriously low sensitivity for detecting malignant nodes. New imaging techniques such as targeted positron emission tomography (PET) imaging and magnetic resonance lymphography (MRL) with iron oxide particles are promising for nodal staging of prostate cancer. In this review, the strengths and limitations of imaging techniques for lymph node staging of prostate cancer are discussed.

  8. Assessment of Stage 35 With APNASA (United States)

    Celestina, Mark L.; Mulac, Richard


    An assessment of APNASA was conducted at NASA Glenn Research Center under the Fundamental Aeronautics Program to determine their predictive capabilities. The geometry selected for this study was Stage 35 which is a single stage transonic compressor. A speedline at 100% speed was generated and compared to experimental data at 100% speed for two turbulence models. Performance of the stage at 100% speed and profiles of several key aerodynamic parameters are compared to the survey data downstream of the stator in this report. In addition, hub leakage was modeled and compared to solutions without leakage and the available experimental data.

  9. Evolutionary transition of dental formula in Late Cretaceous eutherian mammals (United States)

    Averianov, Alexander O.; Archibald, J. David


    Kulbeckia kulbecke, stem placental mammal from the Late Cretaceous of Uzbekistan, shows a transitional stage of evolution in the dental formula from five to four premolars. A non-replaced dP3/dp3 may occur as individual variation. In other specimens, the lower premolars are crowded with no space for development of dp3. As is evident from the CT scanning of one juvenile specimen, the development of dp3 started in a late ontogenetic stage and was confined to the pulp cavity of the developing p2. This dp3 would have been resorbed in a later ontogenetic stage, as the roots of p2 formed. The initial stage of reduction of the third premolar can be traced to stem therians ( Juramaia and Eomaia), which have both dP3 and P3 present in the adult dentition. Further delay in the development of dP3/dp3 led to the loss of the permanent P3/p3 (a possible synapomorphy for Eutheria). The dP3/dp3 was present during most of the adult stages in the Late Cretaceous stem placentals Zhelestidae and Gypsonictops. This tooth is totally absent in basal taxa of Placentalia, which normally have at most four premolars.

  10. Percolation transitions with nonlocal constraint. (United States)

    Shim, Pyoung-Seop; Lee, Hyun Keun; Noh, Jae Dong


    We investigate percolation transitions in a nonlocal network model numerically. In this model, each node has an exclusive partner and a link is forbidden between two nodes whose r-neighbors share any exclusive pair. The r-neighbor of a node x is defined as a set of at most N(r) neighbors of x, where N is the total number of nodes. The parameter r controls the strength of a nonlocal effect. The system is found to undergo a percolation transition belonging to the mean-field universality class for r1/2, the system undergoes a peculiar phase transition from a nonpercolating phase to a quasicritical phase where the largest cluster size G scales as G~N(α) with α=0.74(1). In the marginal case with r=1/2, the model displays a percolation transition that does not belong to the mean-field universality class.

  11. Deconfining transition in Full QCD

    CERN Document Server

    Carmona, J M; Del Debbio, L; Di Giacomo, Adriano; Lucini, B; Paffuti, G; Pica, C


    We present evidence that in full QCD with two dynamical quarks confinement is produced by dual superconductivity of the vacuum as in the quenched theory. Preliminary information is obtained on the nature of the deconfining transition.

  12. The plasma-solid transition

    CERN Document Server

    Celebonovic, V


    Using a criterion proposed by Salpeter and standard solid-state physics,we have determined conditions for the occurence of the plasma-solid transition.Possible astrophysical applications are discussed.

  13. Transition metals in carbohydrate chemistry

    DEFF Research Database (Denmark)

    Madsen, Robert


    This review describes the application of transition metal mediated reactions in carbohydrate synthesis. The different metal mediated transformations are divided into reaction types and illustrated by various examples on monosaccharide derivatives. Carbon-carbon bond forming reactions are further ...

  14. The RN to BSN Transition

    Directory of Open Access Journals (Sweden)

    Allison Brandt Anbari


    Full Text Available Approximately 60% of registered nurses (RNs still enter practice with an associate’s degree or diploma in nursing (ADN. Due to recommendations to change entry level to practice to the bachelor’s degree in nursing (BSN, there are now more than 700 RN to BSN programs in the United States. The purpose of this qualitative systematic review was to understand more about what occurs when an RN returns to school for a BSN and to develop a model of the transition. The qualitative findings of 19 research reports were included, which translates to approximately 445 RNs’ perspectives on the RN to BSN transition. A visual representation of the RN to BSN transition was also generated. A seamless transition of the RN to a BSN does not exist at this time. The results are useful to nurses, academicians, and health care organizations as they move to meet current recommendations.

  15. Vessels in Transit - Web Tool (United States)

    Department of Transportation — A web tool that provides real-time information on vessels transiting the Saint Lawrence Seaway. Visitors may sort by order of turn, vessel name, or last location in...

  16. Coherent Structures in Transition of a Flat-Plate Boundary Layer at Ma=0.7

    Institute of Scientific and Technical Information of China (English)

    ZHOU Ying; LI Xin-Liang; FU De-Xun; MA Yan-Wen


    @@ Direct numerical simulation (DNS) of a spatially evolving flat-plate boundary layer transition process at free stream Mach number 0.7 is performed. Tollmien-Schlichting (T-S) waves are added on the inlet boundary as the disturbances before transition. Typical coherent structures in the transition process are investigated based on the second invariant of velocity gradient tensor. The instantaneous shear stress and the mean velocity profile in the transition region are studied. In our view, the fact that the peak value of shear stress in the stress concentration area increases and exceeds a threshold value during the later stage of the transition process plays an important role in the laminar breakdown process.

  17. Classical Transitions for Flux Vacua

    CERN Document Server

    Deskins, J Tate; Yang, I-Sheng


    We present the simplest model for classical transitions in flux vacua. A complex field with a spontaneously broken U(1) symmetry is embedded in $M_2\\times S_1$. We numerically construct different winding number vacua, the vortices interpolating between them, and simulate the collisions of these vortices. We show that classical transitions are generic at large boosts, independent of whether or not vortices miss each other in the compact $S_1$.

  18. Electron transit time measurements of 5-in photomultiplier tubes (United States)

    Richards, T.; Peatross, J.; Ware, M.; Rees, L.


    We investigated the uniformity of electron transit times for two 5-in photomultiplier tubes: the Hamamatsu R1250 and the Adit B133D01S. We focused a highly attenuated short-pulse laser on the tubes while they were mounted on a programmable stage. The stage translated the tubes relative to the incident beam so that measurements could be made with light focused at points along a grid covering the entire photocathodes. A portion of the incident light was split from the incident beam and measured and recorded by a fast photodiode. Electron transit times were measured by computing the time delay between the recorded photodiode signal and photomultiplier signal using software constant-fraction discrimination. The Hamamatsu tube exhibited a uniform timing response that varied by no more than 1.7 ns. The Adit tube was much less uniform, with transit times that varied by as much as 57 ns. The Adit response also exhibited a spatially varying double-peak structure in its response. The technique described in this paper could be usefully employed by photomultiplier tube manufacturers to characterize the performance of their products.

  19. Transitions in turbulent rotating convection (United States)

    Rajaei, Hadi; Alards, Kim; Kunnen, Rudie; Toschi, Federico; Clercx, Herman; Fluid Dynamics Lab Team


    This study aims to explore the flow transition from one state to the other in rotating Rayleigh-Bènard convection using Lagrangian acceleration statistics. 3D particle tracking velocimetry (3D-PTV) is employed in a water-filled cylindrical tank of equal height and diameter. The measurements are performed at the center and close to the top plate at a Rayleigh number Ra = 1.28e9 and Prandtl number Pr = 6.7 for different rotation rates. In parallel, direct numerical simulation (DNS) has been performed to provide detailed information on the boundary layers. We report the acceleration pdfs for different rotation rates and show how the transition from weakly to strongly rotating Rayleigh-Bènard affects the acceleration pdfs in the bulk and boundary layers. We observe that the shapes of the acceleration PDFs as well as the isotropy in the cell center are largely unaffected while crossing the transition point. However, acceleration pdfs at the top show a clear change at the transition point. Using acceleration pdfs and DNS data, we show that the transition between turbulent states is actually a boundary layer transition between Prandtl-Blasius type (typical of non-rotating convection) and Ekman type.

  20. Shielded multi-stage EMI noise filter (United States)

    Kisner, Roger Allen; Fugate, David Lee


    Electromagnetic interference (EMI) noise filter embodiments and methods for filtering are provided herein. EMI noise filters include multiple signal exclusion enclosures. The multiple signal exclusion enclosures contain filter circuit stages. The signal exclusion enclosures can attenuate noise generated external to the enclosures and/or isolate noise currents generated by the corresponding filter circuits within the enclosures. In certain embodiments, an output of one filter circuit stage is connected to an input of the next filter circuit stage. The multiple signal exclusion enclosures can be chambers formed using conductive partitions to divide an outer signal exclusion enclosure. EMI noise filters can also include mechanisms to maintain the components of the filter circuit stages at a consistent temperature. For example, a metal base plate can distribute heat among filter components, and an insulating material can be positioned inside signal exclusion enclosures.

  1. Classification in two-stage screening. (United States)

    Longford, Nicholas T


    Decision theory is applied to the problem of setting thresholds in medical screening when it is organised in two stages. In the first stage that involves a less expensive procedure that can be applied on a mass scale, an individual is classified as a negative or a likely positive. In the second stage, the likely positives are subjected to another test that classifies them as (definite) positives or negatives. The second-stage test is more accurate, but also more expensive and more involved, and so there are incentives to restrict its application. Robustness of the method with respect to the parameters, some of which have to be set by elicitation, is assessed by sensitivity analysis.

  2. PET for Staging of Esophageal Cancer

    Institute of Scientific and Technical Information of China (English)



    FDG-PET is of clinical value especially for detection of distant metastases or recurrent esophageal cancer. For the staging of primary tumor or locoregional lymph node metastasis PET is currently not suitable.

  3. Low-level waste feed staging plan

    Energy Technology Data Exchange (ETDEWEB)

    Certa, P.J.; Grams, W.H.; McConville, C.M.; L. W. Shelton, L.W.; Slaathaug, E.J., Westinghouse Hanford


    The `Preliminary Low-Level Waste Feed Staging Plan` was updated to reflect the latest requirement in the Tank Waste Remediation Privatization Request for Proposals (RFP) and amendments. The updated plan develops the sequence and transfer schedule for retrieval of DST supernate by the management and integration contractor and delivery of the staged supernate to the private low-activity waste contractors for treatment. Two DSTs are allocated as intermediate staging tanks. A transfer system conflict analysis provides part of the basis for determining transfer system upgrade requirements to support both low-activity and high-level waste feed delivery. The intermediate staging tank architecture and retrieval system equipment are provided as a planning basis until design requirements documents are prepared. The actions needed to successfully implement the plan are identified. These include resolution of safety issues and changes to the feed envelope limits, minimum order quantities, and desired batch sizes.

  4. Konkurss "Sony Jazz Stage" otsib uusi talente

    Index Scriptorium Estoniae


    The Contemporary Music Centre'i korraldatavast konkursist "Sony Jazz Stage 2006". Võistlus toimub vokaali ja bassi (basskitarri või kontrabassi) kategoorias (The Contemporary Music Centre'i posti-või meiliaadress - vt.

  5. Boundary layer transition studies (United States)

    Watmuff, Jonathan H.


    A small-scale wind tunnel previously used for turbulent boundary layer experiments was modified for two sets of boundary layer transition studies. The first study concerns a laminar separation/turbulent reattachment. The pressure gradient and unit Reynolds number are the same as the fully turbulent flow of Spalart and Watmuff. Without the trip wire, a laminar layer asymptotes to a Falkner & Skan similarity solution in the FPG. Application of the APG causes the layer to separate and a highly turbulent and approximately 2D mean flow reattachment occurs downstream. In an effort to gain some physical insight into the flow processes a small impulsive disturbance was introduced at the C(sub p) minimum. The facility is totally automated and phase-averaged data are measured on a point-by-point basis using unprecedently large grids. The evolution of the disturbance has been tracked all the way into the reattachment region and beyond into the fully turbulent boundary layer. At first, the amplitude decays exponentially with streamwise distance in the APG region, where the layer remains attached, i.e. the layer is viscously stable. After separation, the rate of decay slows, and a point of minimum amplitude is reached where the contours of the wave packet exhibit dispersive characteristics. From this point, exponential growth of the amplitude of the disturbance is observed in the detached shear layer, i.e. the dominant instability mechanism is inviscid. A group of large-scale 3D vortex loops emerges in the vicinity of the reattachment. Remarkably, the second loop retains its identify far downstream in the turbulent boundary layer. The results provide a level of detail usually associated with CFD. Substantial modifications were made to the facility for the second study concerning disturbances generated by Suction Holes for laminar flow Control (LFC). The test section incorporates suction through interchangeable porous test surfaces. Detailed studies have been made using isolated

  6. Heat and Mass Transfer of the Droplet Vacuum Freezing Process Based on the Diffusion-controlled Evaporation and Phase Transition Mechanism (United States)

    Zhang, Zhijun; Gao, Jingxin; Zhang, Shiwei


    A frozen phase transition model is developed to investigate the heat and mass transfer of a single water droplet during the vacuum freezing process. The model is based on the diffusion-controlled evaporation mechanism and phase transition characteristics. The droplet vacuum freezing process can be divided into three stages according to the droplet states and the time order. It includes the evaporation freezing stage, the isothermal freezing stage and the sublimation freezing stage. A numerical calculation is performed, and the result is analysed. The effects of the vacuum chamber pressure, initial droplet diameter and initial droplet temperature on the heat and mass transfer characteristics at each stage are studied. The droplet experiences supercooling breakdown at the end of the evaporation freezing stage before the isothermal freezing stage begins. The temperature is transiently raised as a result of the supercooling breakdown phenomenon, whose effects on the freezing process and freezing parameters are considered.

  7. Radiation Therapy for Early Stage Lung Cancer


    Parashar, Bhupesh; Arora, Shruthi; Wernicke, A. Gabriella


    Radiation therapy for early stage lung cancer is a promising modality. It has been traditionally used in patients not considered candidates for standard surgical resection. However, its role has been changing rapidly since the introduction of new and advanced technology, especially in tumor tracking, image guidance, and radiation delivery. Stereotactic radiation therapy is one such advancement that has shown excellent local control rates and promising survival in early stage lung cancer. In a...

  8. Inertial Upper Stage Thermal Test Program (United States)


    REPORT SD-TR-89-26 Inertial Upper Stage Thermal Test Program D. J. SPENCER and H. A. BIXLER Aerophysics Laboratory Laboratory Operations The...TITLE (Include Security Classification) Inertial Upper Stage Thermal Test Program 12. PERSONAL AUTHOR(S) Spencer, Donald J., and Bixler, Henry A. the laboratory thermal test program under consideration here. Details of the IUS launch vehicle characteristics and corrective action taken in

  9. Novel Techniques with the Aid of a Staged CBCT Guided Surgical Protocol

    Directory of Open Access Journals (Sweden)

    Evdokia Chasioti


    Full Text Available The case report will present some novel techniques for using a “staged” protocol utilizing strategic periodontally involved teeth as transitional abutments in combination with CBCT guided implant surgery. Staging the case prevented premature loading of the grafted sites during the healing phase. A CBCT following a tenting screw guided bone regeneration procedure ensured adequate bone to place an implant fixture. Proper assessment of the CBCT allowed the surgeon to do an osteotome internal sinus lift in an optimum location. The depth of the bone needed for the osteotome sinus floor elevation was planned. The staged appliance allowed these sinus-augmented sites to heal for an extended period of time compared to implants, which were uncovered and loaded at an earlier time frame. The staged protocol and CBCT analysis enabled the immediate implants to be placed in proper alignment to the adjacent fixture. After teeth were extracted, the osseointegrated implants were converted to abutments for the transitional appliance. Finally, the staged protocol allowed for soft tissue enhancement in the implant and pontic areas prior to final insertion of the prosthesis.

  10. Alternative splicing during Arabidopsis flower development results in constitutive and stage-regulated isoforms

    Directory of Open Access Journals (Sweden)

    Haifeng eWang


    Full Text Available Alternative splicing (AS is a process in eukaryotic gene expression, in which the primary transcript of a multi-exon gene is spliced into two or more different mature transcripts, thereby increasing proteome diversity. AS is often regulated differentially between different tissues or developmental stages. Recent studies suggested that up to 60% of intron-containing genes in Arabidopsis thaliana undergo AS. Yet little is known about this complicated and important process during floral development. To investigate the preferential expression of different isoforms of individual alternatively spliced genes, we used high throughput RNA-Seq technology to explore the transcriptomes of three floral development stages of Arabidopsis thaliana and obtained information of various alternative splicing events. We identified approximately 24,000 genes that were expressed at one or more of these stages, and found that nearly 25% of multi-exon genes had two or more spliced variants. This is less frequent than the previously reported 40%~60% for multiple organs and stages of A. thaliana, indicating that many genes expressed in floral development function with a single predominant isoform. On the other hand, 1,716 isoforms were differentially expressed between the three stages, suggesting that AS might still play important roles in stage transition during floral development. Moreover, 337 novel transcribed regions were identified and most of them have a single exon. In addition, our analyses provide a comprehensive survey of alternative splicing in floral development and facilitate further genomic and genetic studies.

  11. Transition boiling heat transfer and the film transition regime (United States)

    Ramilison, J. M.; Lienhard, J. H.


    The Berenson (1960) flat-plate transition-boiling experiment has been recreated with a reduced thermal resistance in the heater, and an improved access to those portions of the transition boiling regime that have a steep negative slope. Tests have been made in Freon-113, acetone, benzene, and n-pentane boiling on horizontal flat copper heaters that have been mirror-polished, 'roughened', or teflon-coated. The resulting data reproduce and clarify certain features observed by Berenson: the modest surface finish dependence of boiling burnout, and the influence of surface chemistry on both the minimum heat flux and the mode of transition boiling, for example. A rational scheme of correlation yields a prediction of the heat flux in what Witte and Lienhard (1982) previously identified as the 'film-transition boiling' region. It is also shown how to calculate the heat flux at the boundary between the pure-film, and the film-transition, boiling regimes, as a function of the advancing contact angle.

  12. Extraoral implants for orbit rehabilitation: a comparison between one-stage and two-stage surgeries. (United States)

    de Mello, M C L M P; Guedes, R; de Oliveira, J A P; Pecorari, V A; Abrahão, M; Dib, L L


    The aim of the study was to compare the osseointegration success rate and time for delivery of the prosthesis among cases treated by two-stage or one-stage surgery for orbit rehabilitation between 2003 and 2011. Forty-five patients were included, 31 males and 14 females; 22 patients had two-stage surgery and 23 patients had one-stage surgery. A total 138 implants were installed, 42 (30.4%) on previously irradiated bone. The implant survival rate was 96.4%, with a success rate of 99.0% among non-irradiated patients and 90.5% among irradiated patients. Two-stage patients received 74 implants with a survival rate of 94.6% (four implants lost); one-stage surgery patients received 64 implants with a survival rate of 98.4% (one implant lost). The median time interval between implant fixation and delivery of the prosthesis for the two-stage group was 9.6 months and for the one-stage group was 4.0 months (P < 0.001). The one-stage technique proved to be reliable and was associated with few risks and complications; the rate of successful osseointegration was similar to those reported in the literature. The one-stage technique should be considered a viable procedure that shortens the time to final rehabilitation and facilitates appropriate patient follow-up treatment.

  13. Evaluation of stage acoustics in Seoul Arts Center Concert Hall by measuring stage support. (United States)

    Jeon, Jin Yong; Barron, Michael


    Stage acoustics is an important characteristic for concert halls, both for the acoustic quality on stage and for the audience. However, relatively little research has been conducted into the question. This study was based on the investigation of an actual concert hall stage, that of the Seoul Arts Center Concert Hall in Korea. The stage acoustics was evaluated in the actual hall, and with two models: a 1:25 scale model and a computer model. The study was based on the stage support parameter ST1 proposed by Gade as a measure of support for individual performers [Acustica 65, 193-203 (1989)]. The variation of support was measured on the empty stage of the actual hall and in the two models. The effect of musicians on stage, the effect of moving the orchestra, the effect of ceiling height and of stage-wall profile were also investigated. Conclusions are drawn both relating to the Seoul Concert Hall stage and stages in general.

  14. Design and Experiment of Vertical Motion Dual-stage with Piezo-actuated Nanopositioning Stage

    Institute of Scientific and Technical Information of China (English)

    Ren Jiaqi; Zhu Xiaobo; Chen Guozhen; Liu Pinkuan


    Nanopositioning stage based on piezoelectric (PZT ) actuators and flexure mechanisms has been widely used in dual-stage .Its favorable positioning accuracy and dynamic response can guarantee the high performance of the dual-stage .Here the vertical axis motion dual-stage is designed with piezoelectric actuator for the fine-stage and ball-screw drive integrated with wedge sliding mechanisms for the coarse-stage .The aim of the dual-stage is to meet the stringent requirement of scanning over a relative large range with high accuracy .The design results of the piezo-actuated nanopositioning stage show good static and dynamic performance ,validated by the simulation of fi-nite element analysis (FEA) .Hysteresis nonlinearity due to the use of piezoelectric stacks for actuation is studied and compensated by a proportional-integral (PI) feedback controller .To qualify the design of the motion ranges and resolutions ,an experiment platform is established .The experimental results show that the proposed dual-stage has a full range of 12 mm with the resolution of 40 nm .Guideline is provided for the design methodology of the vertical motion dual-range stages .

  15. GATE (Gaia Transiting Exoplanets): Detecting Transiting Exoplanets with Gaia (United States)

    Zucker, Shay; Eyer, Laurent; Hodgkin, Simon; Clementini, Gisella


    Gaia will have a revolutionary impact on most fields of astronomy. However, its scanning law is too sparse for traditional transit detection approaches (de Bruijne 2012). Practically, only stars brighter than 16th magnitude are relevant for follow-up of transiting exoplanets. For those stars, Gaia's precision is of the order of 1 mmag (Eyer et al. 2015). On average, Gaia will have sampled each target 70 times, but certain stars may be observed as many as 200 times (Voss et al. 2013). Hipparcos scanning law was similar, but its precision much worse. Nevertheless the transit of HD209458 could be seen, aposteriori, in Hipparcos' data (Söderhelm 1999). This inspired our GATE initiative.

  16. Transit fare prepayment: A guide for transit managers. Research report

    Energy Technology Data Exchange (ETDEWEB)

    Mayworm, P.D.; Lago, A.M.


    Transit fare prepayment programs grew rapidly during the past decade with most companies today offering riders several prepayment options. The growth has not been without its costs. The manual provides transit managers with the information and tools necessary to make informed decisions on the design and pricing of fare prepayment plans. Included is information on the true benefits and costs of operating fare prepayment plans. Guidelines on selecting the appropriate plans and distribution methods are presented, as are guidelines on pricing fare prepayment plans in order to capture passenger revenues. A series of straightforward equations are also provided to assist the transit manager in estimating the impacts of changes in a fare prepayment program. The report contains a glossary of terms, a bibliography and a discussion of some fare prepayment demonstration projects.

  17. Social Support as a Moderator for Alcohol-Related Partner Aggression during the Transition to Parenthood (United States)

    Caldeira, Valerie; Woodin, Erica M.


    Alcohol-related partnAer aggression is a pervasive social problem throughout various life stages, including the transition to parenthood. Previous research shows that alcohol use is associated with partner aggression perpetration for both men and women; however, not all individuals who consume alcohol act aggressively. In this study, the…

  18. An Exercise in X-Ray Diffraction Using the Polymorphic Transition of Nickel Chromite. (United States)

    Chipman, David W.


    Describes a laboratory experiment appropriate for a course in either x-ray crystallography or mineralogy. The experiment permits the direct observation of a polymorphic transition in nickel chromite without the use of a special heating stage or heating camera. (Author/GS)

  19. Student Journey Work: A Review of Academic Library Contributions to Student Transition and Success (United States)

    Weaver, Margaret


    This review aims to capture projects, services, and approaches that are being used to ensure student success and sustainability across the stages (or transitions) of the student experience of higher education, where these extend the traditional role of the library, in the UK and internationally. The article examines why the student journey (and…

  20. Predictors of the Transition from Experimental to Daily Smoking in Late Adolescence and Young Adulthood (United States)

    Park, Sunhee; Weaver, Terri E.; Romer, Daniel


    Although smoking initiation is rare in young adulthood, the progression to a higher level of smoking still occurs at this developmental stage. Thus, this study was aimed at exploring predictors of the transition from experimental to daily smoking in late teens and young adults using the 2nd and 3rd waves from the National Longitudinal Study of…

  1. From partnership to parenthood: A review of marital change across the transition to parenthood

    NARCIS (Netherlands)

    Kluwer, E.S.


    The transition to parenthood is generally seen as one of the most challenging events in the early stages of marriage. But is it really that detrimental for marriage and do all couples go through the same changes? This article provides a state-of-the-art review of research on marital change across th

  2. Marxism and the 'Dutch miracle': the Dutch Republic and the transition-debate

    NARCIS (Netherlands)

    Brandon, P.


    The Dutch Republic holds a marginal position in the debate on the transition from feudalism to capitalism, despite its significance in the early stage of the development of global capitalism. While the positions of those Marxists who did consider the Dutch case range from seeing it as the first capi

  3. Marxism and the Dutch Miracle : The Dutch Republic and the transition debate

    NARCIS (Netherlands)

    Brandon, Pepijn


    The Dutch Republic holds a marginal position in the debate on the transition from feudalism to capitalism, despite its significance in the early stage of the development of global capitalism. While the positions of those Marxists who did consider the Dutch case range from seeing it as the first capi

  4. Borrowing and Working of Low-Income Students: The Impact of a Summer Transition Program (United States)

    De La Rosa, Mari Luna


    This study focuses on how low-income students determine employment and student loan borrowing options before they begin college, as part of the final stages of their college choice process. More specifically, this study asks, "during a six-week summer transition program, what choices are made by low-income students with employment or borrowing…

  5. Household Income during Childhood and Young Adult Weight Status: Evidence from a Nutrition Transition Setting (United States)

    Schmeer, Kammi K.


    This article explores whether household income at different stages of childhood is associated with weight status in early adulthood in a nutrition transition setting (a developing country with both underweight and overweight populations). I use multinomial logistic regression to analyze prospective, longitudinal data from Cebu, Philippines.…

  6. A multidimensional decision-making model for internationalization of high-tech SMEs in transition economies

    NARCIS (Netherlands)

    Roersen, M.J.; Groen, A.J.; Kraaijenbrink, J.


    Until now, international entrepreneurship has mainly used stage theory, institutional theory, transaction cost economics and the resource-based view to explain or describe the internationalization of SMEs in transition economy context. Following recent literature we contend that these approaches are

  7. Recruitment and Transition of Construction Lecturers in Further Education: The Perspective of Middle Managers (United States)

    Page, Damien


    This article presents findings from a study of 14 heads of construction in further education colleges in England as they manage the transition of new construction lecturers from a culture of hypermasculinity to one of emotional labour and caring. It focuses firstly on the dilemmas faced by heads of construction at the recruitment stage before…

  8. Transition risk method and example

    Energy Technology Data Exchange (ETDEWEB)

    Schneider, R.E. [Westinghouse Electric Company, Monroeville PA (United States); Farkas, S.E. [Hudson Global Resources (United States)


    Paragraph (a)(4) of the Maintenance Rule (10CFR-50.65) states that before performing maintenance activities, the licensees shall assess and manage the increase in risk that may result from the maintenance activities. Currently, most plants use a qualitative tool for assessing and controlling the risk of the various plant conditions during an outage. Fewer plants have any means of performing a quantitative or qualitative assessment of the associated risks of transitioning the plant in each configuration from power to 'cold shutdown'. Typically, only the end-state of shutdown is considered. Given the concern that the NRC may require quantitative risk assessments of plant transitions and plant configurations during shutdown operations, Omaha Public Power District (OPPD) pro-actively authorized Westinghouse Engineering Services to develop a method for assessing risk associated with a transition from all power to shutdown and back to full power. An outage schedule is highly plant specific. Accordingly, the duration of the transition largely depends on equipment maintenance activities driving the decision to shutdown and repair. The time spent in various parts of the transition is a strong determinant in the associated risk of the transition. A transition takes the plant through a series of Plant Operational States (POSs). The features important to the characterization of each of the POSs include decay-heat level, plant activities involved, available equipment, as well as RCS temperature and pressure. The risk of the entire transition comes from calculating a figure-of-merit of each POS which can be loosely thought of as a per-hour core-damage frequency (CDF). Our paper describes decomposing OPPD operating procedures into periods for which we quantified sequences. In particular, the method considers the dominant shutdown failure modes: loss of shutdown cooling, loss of inventory, and loss of offsite power (including both plant centered and grid-related events

  9. Major transitions in human evolution (United States)

    Foley, Robert A.; Martin, Lawrence; Mirazón Lahr, Marta; Stringer, Chris


    Evolutionary problems are often considered in terms of ‘origins', and research in human evolution seen as a search for human origins. However, evolution, including human evolution, is a process of transitions from one state to another, and so questions are best put in terms of understanding the nature of those transitions. This paper discusses how the contributions to the themed issue ‘Major transitions in human evolution’ throw light on the pattern of change in hominin evolution. Four questions are addressed: (1) Is there a major divide between early (australopithecine) and later (Homo) evolution? (2) Does the pattern of change fit a model of short transformations, or gradual evolution? (3) Why is the role of Africa so prominent? (4) How are different aspects of adaptation—genes, phenotypes and behaviour—integrated across the transitions? The importance of developing technologies and approaches and the enduring role of fieldwork are emphasized. This article is part of the themed issue ‘Major transitions in human evolution’. PMID:27298461

  10. The major synthetic evolutionary transitions (United States)

    Solé, Ricard


    Evolution is marked by well-defined events involving profound innovations that are known as ‘major evolutionary transitions'. They involve the integration of autonomous elements into a new, higher-level organization whereby the former isolated units interact in novel ways, losing their original autonomy. All major transitions, which include the origin of life, cells, multicellular systems, societies or language (among other examples), took place millions of years ago. Are these transitions unique, rare events? Have they instead universal traits that make them almost inevitable when the right pieces are in place? Are there general laws of evolutionary innovation? In order to approach this problem under a novel perspective, we argue that a parallel class of evolutionary transitions can be explored involving the use of artificial evolutionary experiments where alternative paths to innovation can be explored. These ‘synthetic’ transitions include, for example, the artificial evolution of multicellular systems or the emergence of language in evolved communicating robots. These alternative scenarios could help us to understand the underlying laws that predate the rise of major innovations and the possibility for general laws of evolved complexity. Several key examples and theoretical approaches are summarized and future challenges are outlined. This article is part of the themed issue ‘The major synthetic evolutionary transitions’. PMID:27431528

  11. Electromechanical transition in quantum dots (United States)

    Micchi, G.; Avriller, R.; Pistolesi, F.


    The strong coupling between electronic transport in a single-level quantum dot and a capacitively coupled nanomechanical oscillator may lead to a transition towards a mechanically bistable and blocked-current state. Its observation is at reach in carbon-nanotube state-of-art experiments. In a recent publication [Phys. Rev. Lett. 115, 206802 (2015), 10.1103/PhysRevLett.115.206802] we have shown that this transition is characterized by pronounced signatures on the oscillator mechanical properties: the susceptibility, the displacement fluctuation spectrum, and the ring-down time. These properties are extracted from transport measurements, however the relation between the mechanical quantities and the electronic signal is not always straightforward. Moreover the dependence of the same quantities on temperature, bias or gate voltage, and external dissipation has not been studied. The purpose of this paper is to fill this gap and provide a detailed description of the transition. Specifically we find (i) the relation between the current-noise and the displacement spectrum; (ii) the peculiar behavior of the gate-voltage dependence of these spectra at the transition; (iii) the robustness of the transition towards the effect of external fluctuations and dissipation.

  12. Young Exoplanet Transit Initiative (YETI)

    CERN Document Server

    Neuhäuser, R; Berndt, A; Maciejewski, G; Takahashi, H; Chen, W P; Dimitrov, D P; Pribulla, T; Nikogossian, E H; Jensen, E L N; Marschall, L; Wu, Z -Y; Kellerer, A; Walter, F M; Briceño, C; Chini, R; Fernandez, M; Raetz, St; Torres, G; Latham, D W; Quinn, S N; Niedzielski, A; Bukowiecki, Ł; Nowak, G; Tomov, T; Tachihara, K; Hu, S C -L; Hung, L W; Radeva, D P Kjurkchieva \\and V S; Mihov, B M; Slavcheva-Mihova, L; Bozhinova, I N; Budaj, J; Vaňko, M; Kundra, E; Hambálek, Ľ; Krushevska, V; Movsessian, T; Harutyunyan, H; Downes, J J; Hernandez, J; Hoffmeister, V H; Cohen, D H; Abel, I; Ahmad, R; Chapman, S; Eckert, S; Goodman, J; Guerard, A; Kim, H M; Koontharana, A; Sokol, J; Trinh, J; Wang, Y; Zhou, X; Redmer, R; Kramm, U; Nettelmann, N; Mugrauer, M; Schmidt, J; Moualla, M; Ginski, C; Marka, C; Adam, C; Seeliger, M; Baar, S; Roell, T; Schmidt, T O B; Trepl, L; Eisenbei\\ss, T; Fiedler, S; Tetzlaff, N; Schmidt, E; Hohle, M M; Kitze, M; Chakrova, N; Gräfe, C; Schreyer, K; Hambaryan, V V; Broeg, C H; Koppenhoefer, J; Pandey, A K


    We present the Young Exoplanet Transit Initiative (YETI), in which we use several 0.2 to 2.6m telescopes around the world to monitor continuously young (< 100 Myr), nearby (< 1 kpc) stellar clusters mainly to detect young transiting planets (and to study other variability phenomena on time-scales from minutes to years). The telescope network enables us to observe the targets continuously for several days in order not to miss any transit. The runs are typically one to two weeks long, about three runs per year per cluster in two or three subsequent years for about ten clusters. There are thousands of stars detectable in each field with several hundred known cluster members, e.g. in the first cluster observed, Tr-37, a typical cluster for the YETI survey, there are at least 469 known young stars detected in YETI data down to R=16.5 mag with sufficient precision of 50 milli-mag rms (5 mmag rms down to R=14.5 mag) to detect transits, so that we can expect at least about one young transiting object in this cl...

  13. Observation of optomechanical buckling transitions (United States)

    Xu, H.; Kemiktarak, U.; Fan, J.; Ragole, S.; Lawall, J.; Taylor, J. M.


    Correlated phases of matter provide long-term stability for systems as diverse as solids, magnets and potential exotic quantum materials. Mechanical systems, such as buckling transition spring switches, can have engineered, stable configurations whose dependence on a control variable is reminiscent of non-equilibrium phase transitions. In hybrid optomechanical systems, light and matter are strongly coupled, allowing engineering of rapid changes in the force landscape, storing and processing information, and ultimately probing and controlling behaviour at the quantum level. Here we report the observation of first- and second-order buckling transitions between stable mechanical states in an optomechanical system, in which full control of the nature of the transition is obtained by means of the laser power and detuning. The underlying multiwell confining potential we create is highly tunable, with a sub-nanometre distance between potential wells. Our results enable new applications in photonics and information technology, and may enable explorations of quantum phase transitions and macroscopic quantum tunnelling in mechanical systems.

  14. The Epithelial-Mesenchymal Transition Factor SNAIL Paradoxically Enhances Reprogramming

    Directory of Open Access Journals (Sweden)

    Juli J. Unternaehrer


    Full Text Available Reprogramming of fibroblasts to induced pluripotent stem cells (iPSCs entails a mesenchymal to epithelial transition (MET. While attempting to dissect the mechanism of MET during reprogramming, we observed that knockdown (KD of the epithelial-to-mesenchymal transition (EMT factor SNAI1 (SNAIL paradoxically reduced, while overexpression enhanced, reprogramming efficiency in human cells and in mouse cells, depending on strain. We observed nuclear localization of SNAI1 at an early stage of fibroblast reprogramming and using mouse fibroblasts expressing a knockin SNAI1-YFP reporter found cells expressing SNAI1 reprogrammed at higher efficiency. We further demonstrated that SNAI1 binds the let-7 promoter, which may play a role in reduced expression of let-7 microRNAs, enforced expression of which, early in the reprogramming process, compromises efficiency. Our data reveal an unexpected role for the EMT factor SNAI1 in reprogramming somatic cells to pluripotency.

  15. Nonclassical congenital adrenal hyperplasia: targets of treatment and transition. (United States)

    McCann-Crosby, Bonnie; Chen, Min-Jye; Lyons, Sarah K; Lin, Yuezhen; Axelrad, Marni; Dietrich, Jennifer E; Sutton, V Reid; Macias, Charles G; Gunn, Sheila; Karaviti, Lefkothea


    Nonclassical congenital adrenal hyperplasia (NCCAH) caused by 21-hydroxylase deficiency is a common autosomal recessive condition that can present with a wide range of hyperandrogenemic signs in childhood or adulthood. The management of children with NCCAH can be challenging, as no universally accepted guidelines have been established. Our goal was to evaluate the literature and develop an evidence-based guideline for the medical management of children and adolescents with NCCAH. We reviewed the published literature and used the Grading of Recommendation, Assessment, Development, and Evaluation (GRADE) system when appropriate to grade the evidence and provide recommendations for the medical management of children and adolescents with NCCAH, appropriate transition practices from pediatric to adult endocrine care, and psychological issues that should be addressed in parents and patients with NCCAH. We offer recommendations, based on the available evidence, for the management of NCCAH at the different developmental stages from diagnosis through transition to adulthood.

  16. Origin of the phase transition in lithiated molybdenum disulfide

    KAUST Repository

    Cheng, Yingchun


    Phase transitions and phase engineering in two-dimensional MoS2 are important for applications in electronics and energy storage. By in situ transmission electron microscopy, we find that H-MoS2 transforms to T-LiMoS2 at the early stages of lithiation followed by the formation of Mo and Li2S phases. The transition from H-MoS2 to T-LiMoS2 is explained in terms of electron doping and electron - phonon coupling at the conduction band minima. Both are essential for the development of two-dimensional semiconductor-metal contacts based on MoS2 and the usage of MoS2 as anode material in Li ion batteries. (Figure Presented).

  17. A proposed staging system and stage-specific interventions for familial adenomatous polyposis

    DEFF Research Database (Denmark)

    Lynch, Patrick M; Morris, Jeffrey S; Wen, Sijin;


    in polyp burden as a sufficient chemoprevention trial treatment endpoint requiring a measure of "clinical-benefit." To develop endpoints for future industry-sponsored chemopreventive trials, the International Society for Gastrointestinal Hereditary Tumors (InSIGHT) developed an FAP staging and intervention...... classification scheme for lower GI tract polyposis. METHODS: Twenty-four colonoscopy or sigmoidoscopy videos were reviewed by 26 clinicians familiar with diagnosis and treatment of FAP. The reviewers independently assigned a stage to a case using the proposed system and chose a stage-specific intervention......% of scores were within ±1 stage of the mode. Sixty percent agreed on the intervention, and 86% chose an intervention within ±1 level of the mode. CONCLUSIONS: The proposed FAP colon polyposis staging system and stage-specific intervention is based on a high degree of agreement on the part of experts...

  18. Cisplatin and Radiation Therapy With or Without Triapine in Treating Patients With Previously Untreated Stage IB-IVA Cervical Cancer or Stage II-IVA Vaginal Cancer (United States)


    Cervical Adenocarcinoma; Cervical Adenosquamous Carcinoma; Cervical Squamous Cell Carcinoma; Stage IB2 Cervical Cancer; Stage II Vaginal Cancer; Stage IIA1 Cervical Cancer; Stage IIA2 Cervical Cancer; Stage IIB Cervical Cancer; Stage III Vaginal Cancer; Stage IIIA Cervical Cancer; Stage IIIB Cervical Cancer; Stage IVA Cervical Cancer; Stage IVA Vaginal Cancer; Vaginal Adenocarcinoma; Vaginal Adenosquamous Carcinoma; Vaginal Squamous Cell Carcinoma

  19. Evaluation of lymph node numbers for adequate staging of Stage II and III colon cancer

    Directory of Open Access Journals (Sweden)

    Bumpers Harvey L


    Full Text Available Abstract Background Although evaluation of at least 12 lymph nodes (LNs is recommended as the minimum number of nodes required for accurate staging of colon cancer patients, there is disagreement on what constitutes an adequate identification of such LNs. Methods To evaluate the minimum number of LNs for adequate staging of Stage II and III colon cancer, 490 patients were categorized into groups based on 1-6, 7-11, 12-19, and ≥ 20 LNs collected. Results For patients with Stage II or III disease, examination of 12 LNs was not significantly associated with recurrence or mortality. For Stage II (HR = 0.33; 95% CI, 0.12-0.91, but not for Stage III patients (HR = 1.59; 95% CI, 0.54-4.64, examination of ≥20 LNs was associated with a reduced risk of recurrence within 2 years. However, examination of ≥20 LNs had a 55% (Stage II, HR = 0.45; 95% CI, 0.23-0.87 and a 31% (Stage III, HR = 0.69; 95% CI, 0.38-1.26 decreased risk of mortality, respectively. For each six additional LNs examined from Stage III patients, there was a 19% increased probability of finding a positive LN (parameter estimate = 0.18510, p Conclusions Thus, the 12 LN cut-off point cannot be supported as requisite in determining adequate staging of colon cancer based on current data. However, a minimum of 6 LNs should be examined for adequate staging of Stage II and III colon cancer patients.

  20. Controversies in Surgical Staging of Endometrial Cancer

    Directory of Open Access Journals (Sweden)

    R. Seracchioli


    Full Text Available Endometrial cancer is the most common gynaecological malignancy and its incidence is increasing. In 1998, international federation of gynaecologists and obstetricians (FIGO required a change from clinical to surgical staging in endometrial cancer, introducing pelvic and paraaortic lymphadenectomy. This staging requirement raised controversies around the importance of determining nodal status and impact of lymphadenectomy on outcomes. There is agreement about the prognostic value of lymphadenectomy, but its extent, therapeutic value, and benefits in terms of survival are still matter of debate, especially in early stages. Accurate preoperative risk stratification can guide to the appropriate type of surgery by selecting patients who benefit of lymphadenectomy. However, available preoperative and intraoperative investigations are not highly accurate methods to detect lymph nodes and a complete surgical staging remains the most precise method to evaluate extrauterine spread of the disease. Laparotomy has always been considered the standard approach for endometrial cancer surgical staging. Traditional and robotic-assisted laparoscopic techniques seem to provide equivalent results in terms of disease-free survival and overall survival compared to laparotomy. These minimally invasive approaches demonstrated additional benefits as shorter hospital stay, less use of pain killers, lower rate of complications and improved quality of life.

  1. Hybrid staging of geothermal energy conversion processes

    Energy Technology Data Exchange (ETDEWEB)

    Steidel, R.F.


    A hybrid system consists of two or more energy conversion processes. This study examines the use of three energy conversion machines in hybrid systems: the conventional single-phase turbine, and the two-phase expanders known as the Lysholm engine and the radial outflow reaction turbine. Two hybrid systems are presented. The first is a two-stage, single-flash system with the Lysholm engine as the first stage, and a separator and conventional turbine as the second stage. The second system adds a radial outflow reaction turbine to recover a part of the energy rejected in the second stage. A theoretical specific power of 41.3 kW.s/lb is predicted for the two-stage, single-flash hybrid system. The addition of the radial outflow rotary turbine increases performance to 44.8 kW.s/lb. Both are superior to the double-flash system, with a specific power of 37.8 kW.s/lb. In addition, the hybrid system offers operating flexibility.

  2. Staging properties of potassium-ammonia ternary graphite intercalation compounds at high ammonia pressure (United States)

    Qian, X. W.; Solin, S. A.


    The pressure dependence of the (00l) x-ray diffraction patterns of the ternary graphite intercalation compound K(NH3)xC24 has been studied in the range 0.5-11 kbar (for which x~4.5) using a diamond anvil cell. A special apparatus for loading the cell with liquid ammonia at room temperature has been constructed and is briefly described. In these experiments, the pressure-transmitting fluid was also an intercalant, namely ammonia. Therefore, the chemical potential of this species was linearly coupled to the applied pressure in contrast to the usual case where the pressure-transmitting fluid is chemically passive. The pressure dependences of the basal spacings and of the relative intensities of key reflections have been measured, as have the compressibilities of the stage-1 and stage-2 components of the two-phase system. Basal-spacing anomalies and anomalies in the relative intensities occur at pressures of ~3.5 and 8.0 kbar and are tentatively attributed to in-plane coordination changes in the potassium-ammonia ratio. Using thermodynamic arguments and Le Chatelier's principle we show quantitatively that a staging phase transition from pure stage-1 phase to an admixture of stage-1 and stage-2 is expected with increased pressure above 10 bar in agreement with experiment. The saturation ammonia compositions (x values) of the admixed stages are found to be 4.5 and 5.4 for the stage-1 and -2 components, respectively. This result is interpreted as evidence that the composition is not sterically limited but is determined by the binding energy of ammonia for potassium and by the perturbation to this energy from the guest-host interaction.

  3. The Structural Phase Transition in Solid DCN

    DEFF Research Database (Denmark)

    Dietrich, O. W.; Mackenzie, Gordon A.; Pawley, G. S.


    Neutron scattering measurements on deuterated hydrogen cyanide have shown that the structural phase transition from a tetragonal to an orthorhombic form at 160 K is a first order transition. A transverse acoustic phonon mode, which has the symmetry of the transition was observed at very low energ...... energies and showed “softening” as the transition was approached from above.......Neutron scattering measurements on deuterated hydrogen cyanide have shown that the structural phase transition from a tetragonal to an orthorhombic form at 160 K is a first order transition. A transverse acoustic phonon mode, which has the symmetry of the transition was observed at very low...

  4. Quantum Transition-State Theory

    CERN Document Server

    Hele, Timothy J H


    This dissertation unifies one of the central methods of classical rate calculation, `Transition-State Theory' (TST), with quantum mechanics, thereby deriving a rigorous `Quantum Transition-State Theory' (QTST). The resulting QTST is identical to ring polymer molecular dynamics transition-state theory (RPMD-TST), which was previously considered a heuristic method, and whose results we thereby validate. The key step in deriving a QTST is alignment of the flux and side dividing surfaces in path-integral space to obtain a quantum flux-side time-correlation function with a non-zero $t\\to 0_+$ limit. We then prove that this produces the exact quantum rate in the absence of recrossing by the exact quantum dynamics, fulfilling the requirements of a QTST. Furthermore, strong evidence is presented that this is the only QTST with positive-definite Boltzmann statistics and therefore the pre-eminent method for computation of thermal quantum rates in direct reactions.

  5. The Transitional Legend of Winners

    Directory of Open Access Journals (Sweden)

    Ivan Kovačević


    Full Text Available During 2006 a number of stories that featured the motive of great gain under dramatic circumstances were repeatedly told in betting-houses in Kragujevac, a town in Serbia. The main character of these legends is an empoverished victim of transition who, thanks to luck and help of friends, wins a great sum of money betting. Besides describing the preceding transitional "fall" of the winner (getting fired, failing in private enterprise, the legends describe his economical and social prosperity initiated by capital gained through betting (starting succesfull enterprises, buying good shares. Diachronically following other "sudden wealth" legends this transitional legend speaks about the establishing of a new system of values that, in the categories of social promotion, makes up for the old principles that marked the period of socialism.

  6. Researching literacy practices in transition

    DEFF Research Database (Denmark)

    Holm, Lars

    Researching literacy practices in transition Postmodern societies are characterized by constant, fast and unpredictable mobility of people, goods, ideas and values. These mobilities are often visualized as a movement from one place to another, as a temporary interference of the stability of fixed...... places. An alternative take on mobilty sees movement as the default and change as the normal way of being rather than the exception (Barton, 2012). This understanding of change is central to the framing concept of this symposium: transition. Transitional processes around literacy are significant because...... literacy is something that is taught and learned, that is adopted, transformed and appropriated and that is used to categorize and classify people (Holm & Pitkänen-Huhta, 2012). Based on detailed empirical studies in the Nordic countries, the aim of this symposium is to discuss how to explore and research...

  7. Sliding Over a Phase Transition (United States)

    Tosatti, Erio; Benassi, Andrea; Vanossi, Andrea; Santoro, Giuseppe E.


    The frictional response experienced by a stick-slip slider when a phase transition occurs in the underlying solid substrate is a potentially exciting, poorly explored problem. We show, based on 2-dimensional simulations modeling the sliding of a nanotip, that indeed friction may be heavily affected by a continuous structural transition. First, friction turns nonmonotonic as temperature crosses the transition, peaking at the critical temperature Tc where fluctuations are strongest. Second, below Tc friction depends upon order parameter directions, and is much larger for those where the frictional slip can cause a local flip. This may open a route towards control of atomic scale friction by switching the order parameter direction by an external field or strain, with possible application to e.g., displacive ferroelectrics such as BaTi O3 , as well as ferro- and antiferro-distortive materials. Supported by project ESF FANAS/AFRI sponsored by the Italian Research Council (CNR).

  8. Trust transitivity in social networks

    CERN Document Server

    Richters, Oliver


    Non-centralized recommendation-based decision making is a central feature of several social and technological processes, such as market dynamics, peer-to-peer file-sharing and the web of trust of digital certification. We investigate the properties of trust propagation on networks, based on a simple metric of trust transitivity. We investigate analytically the percolation properties of trust transitivity in random networks with arbitrary degree distribution, and compare with numerical realizations. We find that the existence of a non-zero fraction of absolute trust (i.e. entirely confident trust) is a requirement for the viability of global trust propagation in large systems: The average pair-wise trust is marked by a discontinuous transition at a specific fraction of absolute trust, below which it vanishes. Furthermore, we perform an extensive analysis of the Pretty Good Privacy (PGP) web of trust, in view of the concepts introduced. We compare different scenarios of trust distribution: community- and author...

  9. Towards a sustainable urban transition?

    DEFF Research Database (Denmark)

    Lissandrello, Enza; Cappellaro, Francesca


    Never as today the discourse about uncertainty is permeating and affecting traditional paradigms of urban planning. Predictable futures are no longer possible, sufficient to understand it in the long term and adequate. If the future looks uncertain, the debate on sustainable development has...... contributed to render the situation even more complex and planning practitioners are now navigating between an unclear perception of future risks and the hope for results and visions for long-term perspectives of urban futures. Among scholars engaged in the study of sustainable transitions in urban areas...... the challenges for planning urban transitions with an analytic based on how professional practitioners actually think and reflect on a set of projects in view of integral urban planning actions in Bologna. Through a critical reading of transition studies in urban contexts and a dialogue with policy actors...

  10. Comparative Habitability of Transiting Exoplanets

    CERN Document Server

    Barnes, Rory; Evans, Nicole


    Exoplanet habitability is traditionally assessed by comparing a planet's semi-major axis to the location of its host star's "habitable zone," the shell around a star for which Earth-like planets can possess liquid surface water. The Kepler space telescope has discovered numerous planet candidates near the habitable zone, and many more are expected from missions such as K2, TESS and PLATO. These candidates often require significant follow-up observations for validation, so prioritizing planets for habitability from transit data has become an important aspect of the search for life in the universe. We propose a method to compare transiting planets for their potential to support life based on transit data, stellar properties and previously reported limits on planetary emitted flux. For a planet in radiative equilibrium, the emitted flux increases with eccentricity, but decreases with albedo. As these parameters are often unconstrained, there is an "eccentricity-albedo degeneracy" for the habitability of transiti...


    Institute of Scientific and Technical Information of China (English)

    Hu Yuxiang; Ma Xiangjie; Lan Julong; Wang Haoxue


    Current MSM switching fabric has poor performance under unbalanced traffic. This paper presents an alternative, novel Central-stage Buffered Three-stage Clos switching (CB-3Clos) fabric and proves that this fabric can emulate output queuing switch without any speedup. By analyzing the condition to satisfy the central-stage load-balance, this paper also proposes a Central-stage Load-balanced-based Distributed Scheduling algorithm (CLDS) for CB-3Clos. The results show that, compared with Concurrent Round-Robin based Dispatching (CRRD) algorithm based on MSM, CLDS algorithm has high throughput irrespective with the traffic model and better performance in mean packet delay.

  12. The colocalization transition of homologous chromosomes at meiosis (United States)

    Nicodemi, Mario; Panning, Barbara; Prisco, Antonella


    Meiosis is the specialized cell division required in sexual reproduction. During its early stages, in the mother cell nucleus, homologous chromosomes recognize each other and colocalize in a crucial step that remains one of the most mysterious of meiosis. Starting from recent discoveries on the system molecular components and interactions, we discuss a statistical mechanics model of chromosome early pairing. Binding molecules mediate long-distance interaction of special DNA recognition sequences and, if their concentration exceeds a critical threshold, they induce a spontaneous colocalization transition of chromosomes, otherwise independently diffusing.

  13. Kinetics of the Bicelle to Lamellae Transition in Phospholipid Mixtures (United States)

    Wang, Howard; Nieh, Mu-Ping; Hobbie, Erik K.; Glinka, Charles J.; Katsaras, John


    The kinetics of the bicelle to lamellae transition in phospholipid mixtures of DMPC/DHPC is investigated using time-resolved small-angle neutron scattering. The data suggest that ordering in these mixtures is a multi-stage process, initiated by the coalescence of bicelles into stacked membrane layers, and limited at late time by the coarsening and swelling of stacks and pinning due to defects. The time evolution of the ordering process is quantified via structural scaling of the non-equilibrium structure factor.

  14. The Maternal-to-Zygotic Transition in Higher Plants

    Institute of Scientific and Technical Information of China (English)

    Hai-Ping Xin; Jing Zhao; Meng-Xiang Sun


    During early embryogenesis in mammals and higher plants,the maternalto-zygotic transition (MZT) marks the turnover of developmental control from maternal products to de novo zygotic genome transcripts.Intensive studies in animals indicate that early embryonic development is largely maternally controlled.In recent years,the MZT has drawn the attention of botanists,as it is important for understanding the mechanism of embryogenesis and hybrid vigor.In this study,we present a brief overview of some aspects of the MZT in flowering plants.Based on what we have learned from Nicotiana tabacum,we hypothesize that the MZT occurs before zygotic cell division and that the development of the fertilized egg cell in flowering plants can be divided into two phases:the zygote stage,which is mainly controlled maternally,and the one-celled proembryo stage,in which zygotic genome activation (ZGA) occurs and is required for zygote division.

  15. Power in Transition: Empowering Discourses on Sustainability Transitions

    NARCIS (Netherlands)

    F. Avelino (Flor)


    textabstractThis is a book about power and transformative change. It explores how groups of people who are trying to transform the mobility system are affected by notions of change and power, and how they deal with the dilemmas of power. Academic literature on power and transitions offers concepts t

  16. Wetting transition on patterned surfaces: transition states and energy barriers. (United States)

    Ren, Weiqing


    We study the wetting transition on microstructured hydrophobic surfaces. We use the string method [J. Chem. Phys. 2007, 126, 164103; J. Chem. Phys. 2013, 138, 134105] to accurately compute the transition states, the energy barriers, and the minimum energy paths for the wetting transition from the Cassie-Baxter state to the Wenzel state. Numerical results are obtained for the wetting of a hydrophobic surface textured with a square lattice of pillars. It is found that the wetting of the solid substrate occurs via infiltration of the liquid in a single groove, followed by lateral propagation of the liquid front. The propagation of the liquid front proceeds in a stepwise manner, and a zipping mechanism is observed during the infiltration of each layer. The minimum energy path for the wetting transition goes through a sequence of intermediate metastable states, whose wetted areas reflect the microstructure of the patterned surface. We also study the dependence of the energy barrier on the drop size and the gap between the pillars.

  17. Imaging the earliest stages of Alzheimer's disease. (United States)

    Wu, William; Small, Scott A


    Historical progress in medicine can be charted along the lines of technical innovations that have visualized the invisible. One hundred years ago, Alois Alzheimer exploited newly developed histological stains to visualize his eponymonous disease in dead tissue under the microscope. Now, as we are entering the second century of Alzheimer's disease research, technical innovation has endowed us with a range of in vivo imaging techniques that promise to visualize Alzheimer' disease in living people. The earliest stage of Alzheimer's disease is characterized by cell-sickness, not cell-death, and can occur before the deposition of amyloid plaques or neurofibrillary tangles. In principle, 'functional' imaging techniques might be able to detect this early stage of the disease, a stage that was invisible to Alzheimer himself. Here, we will first define the neurobiological meaning of 'function' and then review the different approaches that measure brain dysfunction in Alzheimer' disease.

  18. Comparative myoanatomy of cycliophoran life cycle stages

    DEFF Research Database (Denmark)

    Neves, Ricardo C.; Cunha, Marina R; Funch, Peter


    The metazoan phylum Cycliophora includes small cryptic epibionts that live attached to the mouthparts of clawed lobsters. The life cycle is complex, with alternating sexual and asexual generations, and involves several sessile and free-living stages. So far, the morphological and genetic...... on the dorsal side, whereas on the ventral side, longitudinal muscles and a V-shaped muscle structure are present. These muscles are complemented by additional dorsoventral muscles. The mesodermal muscle fibers attach to the cuticle via the epidermis in all life cycle stages studied herein. The musculature...... of the female is similar to that of the Pandora larva of Symbion americanus and includes dorsoventral muscles and longitudinal muscles that run in the dorsal and ventral body region. Overall, our results reveal striking similarities in the muscular arrangement of the life cycle stages of both Symbion species. J...

  19. The three stages of magma ocean cooling (United States)

    Warren, Paul H.


    Models of magma ocean (MO) cooling and crystallization can provide important constraints on MO plausibility for a given planet, on the origin of long term, stable crusts, and even on the origin of the solar system. Assuming the MO is initially extensive enough to have a mostly molten surface, its first stage of cooling is an era of radiative heat loss from the surface, with extremely rapid convection below, and no conductive layer in between. The development of the chill crust starts the second stage of MO cooling. Heat loss is now limited by conduction through the crust. The third stage of cooling starts when the near surface MO evolves compositionally to the point of saturation with feldspar. At this point, the cooling rate again precipitously diminishes, the rate of crustal thickness growth as a function of temperature suddenly increases. More work on incorporating chemical constraints into the evolving physical models of MO solidification would be worthwhile.


    Energy Technology Data Exchange (ETDEWEB)

    Per Onnerud; Suresh Sriramulu


    TIAX has executed a laboratory-based development program aiming at the improvement of stationary fuel cell systems. The two-year long development program resulted in an improved understanding of staged fuel cells and inorganic proton conductors through evaluation of results from a number of laboratory tasks: (1) Development of a fuel cell modeling tool--Multi-scale model was developed, capable of analyzing the effects of materials and operating conditions; and this model allowed studying various ''what-if'' conditions for hypothetically staged fuel cells; (2) Study of new high temperature proton conductor--TIAX discovery of a new class of sulfonated inorganics capable of conducting protons when exposed to water; and study involved synthesis and conductivity measurements of novel compounds up to 140 C; (3) Electrochemical fuel cell measurements--the feasibility of staged fuel cells was tested in TIAX's fuel cell laboratories experimental design was based on results from modeling.

  1. Stage- vs. Channel-strip Metaphor

    DEFF Research Database (Denmark)

    Gelineck, Steven; Korsgaard, Dannie Michael; Büchert, Morten


    This study compares the stage metaphor and the channel strip metaphor in terms of performance. Traditionally, music mixing consoles employ a channels strip control metaphor for adjusting parameters such as volume and panning of each track. An alternative control metaphor, the so-called stage...... metaphor lets the user adjust volume and panning by positioning tracks relative to a virtual listening position. In this study test participants are given the task to adjust volume and panning of one channel (in mixes consisting of three channels) in order to replicate a series of simple pre-rendered mixes....... They do this using (1) a small physical mixing controller and (2) using an iPad app, which implements a simple stage metaphor interface. We measure how accurately they are able to replicate mixes in terms of volume and panning and how fast they are at doing so. Results reveal that performance...

  2. Time-Limited Psychotherapy: An Interactional Stage Model. (United States)

    Tracey, Terence J.

    One model of successful time-limited psychotherapy characterizes the therapy as a movement through three interactional stages: the early rapport attainment stage, the middle conflict stage, and the final resolution stage. According to this model, these stages are indicated by the relative presence of communicational harmony. To examine the…

  3. Stagering: Een ontwikkelingspuzzel [The challenge of staging developmental disorders

    NARCIS (Netherlands)

    Gaag, R.J. van der; Wijngaarden-Cremers, P.J. van; Staal, W.G.


    BACKGROUND: On the basis of our current knowledge, developmental disorders can be divided into the following stages: stage 0: normal variation, stage 1: simple disorder of moderate severity, stage 2: complicating co-morbidity and/or harmful background circumstances, and stage 3: serious disorder wit

  4. Thailand's Work and Health Transition. (United States)

    Kelly, Matthew; Strazdins, Lyndall; Dellora, Tarie; Khamman, Suwanee; Seubsman, Sam-Ang; Sleigh, Adrian C


    Thailand has experienced a rapid economic transition from agriculture to industry and services, and from informal to formal employment. It has much less state regulation and worker representation relative to developed nations, who underwent these transitions more slowly and sequentially, decades earlier. We examine the strengthening of Thai government policy and legislation affecting worker's health, responding to international norms, a new democratic constitution, fear of foreign importer embargos and several fatal workplace disasters. We identify key challenges remaining for Thai policy makers, including legislation enforcement and the measurement of impacts on worker's mental and physical health.

  5. Gendering agency in transitional justice

    DEFF Research Database (Denmark)

    Björkdahl, Annika; Selimovic, Johanna Mannergren


    . To address this lacuna we conceptualize and unpack the meaning of gendered agency, by identifying its critical elements and by locating it in space and in time. The conceptual work that we undertake is underpinned by empirical mapping of the transitional justice spaces in post-conflict Bosnia....... Such research enables us to engage with the subjects of post-conflict peacebuilding and transitional justice processes directly and in their own spaces. This article thus renders women’s agency visible and attempts to grasp its contributions and consequences for transformations from war to peace....

  6. Phase transitions and critical phenomena

    CERN Document Server

    Domb, Cyril


    The field of phase transitions and critical phenomena continues to be active in research, producing a steady stream of interesting and fruitful results. It has moved into a central place in condensed matter studies.Statistical physics, and more specifically, the theory of transitions between states of matter, more or less defines what we know about 'everyday' matter and its transformations.The major aim of this serial is to provide review articles that can serve as standard references for research workers in the field, and for graduate students and others wishing to obtain reliable in

  7. A Pipelined Non-Deterministic Finite Automaton-Based String Matching Scheme Using Merged State Transitions in an FPGA. (United States)

    Kim, HyunJin; Choi, Kang-Il


    This paper proposes a pipelined non-deterministic finite automaton (NFA)-based string matching scheme using field programmable gate array (FPGA) implementation. The characteristics of the NFA such as shared common prefixes and no failure transitions are considered in the proposed scheme. In the implementation of the automaton-based string matching using an FPGA, each state transition is implemented with a look-up table (LUT) for the combinational logic circuit between registers. In addition, multiple state transitions between stages can be performed in a pipelined fashion. In this paper, it is proposed that multiple one-to-one state transitions, called merged state transitions, can be performed with an LUT. By cutting down the number of used LUTs for implementing state transitions, the hardware overhead of combinational logic circuits is greatly reduced in the proposed pipelined NFA-based string matching scheme.

  8. Impact of age at onset for children with renal failure on education and employment transitions. (United States)

    Lewis, Helen; Arber, Sara


    Previous medical research has shown that children with end-stage renal failure experience delay or underachievement of key markers of transition to adulthood. This article analyses 35 qualitative interviews with end-stage renal failure patients, aged 20-30 years, first diagnosed at 0-19 years of age, to explore how far delayed or underachievement in education and employment is related to their age at onset of end-stage renal failure. This study shows how unpredictable failures of renal replacement therapies, comorbidities and/or side effects of treatment in the early life course often coincided with critical moments for education and employment. Entering school, college, work-related training or employment, and disclosing health status or educational underachievement to an employer, were particularly critical, and those who were ill before puberty became progressively more disadvantaged in terms of successful transition into full-time employment, compared with those first diagnosed after puberty.

  9. Induced Institutional Transition of Contract Farming in Shandong Province

    Institute of Scientific and Technical Information of China (English)


    This article describes the process of institutional transition of contract farming in Shandong Province. The changes in preparatory stage of contract farming express in: One, the information asymmetry of the two sides of the contract is reducing; Two, the security system of contract farming tends to be perfection; Three, the organizational form of contract farming tends to be simplification. The measures taken in production stage of agricultural product are as follows: The first is investment in means of production; The second is perfection of field management; The third is soundness of quality test. The measures taken in purchase stage of agricultural product are as follows: First, product is developing from preliminary working to intensive processing; Second, leading enterprises develop to large-scale and standard. The changes in profit distribution stage of contract farming are as follows: First, the profit relationship between enterprises and peasant households turns from opposition to mutual benefit. Second, the means of default issues turn from emotional self-discipline to rational self-discipline. Performance of contract farming is analyzed: First is putting forward the transformation of agricultural operational form; Second is reducing the uncertainty; Third is truly realizing the risk sharing and participation of interest. The defect of institutional transition of contract farming is discussed: First is no longer the operational form that benefits many farmers; Second is still the typically incomplete contract; Third is expansion of capability gap of business game between leading enterprises and farmers; Fourth is the still existence of information asymmetry; Fifth is informal institution falling behind formal institutional arrangement. The corresponding countermeasures are put forward: First is developing professional cooperation; Second is completing land circulation system; Third is constructing honest information system; Fourth is building social

  10. Nature of Rutile Nuclei in Anatase-to-Rutile Phase Transition. (United States)

    Zhu, Sheng-Cai; Xie, Song-Hai; Liu, Zhi-Pan


    The solid phase transition of TiO2, in particular anatase to rutile, has been extensively studied in the past 30 years. To seek the nucleation site at the beginning of phase transition is highly challenging, which asks for new theoretical techniques with high spatial and temporal resolution. This work reports the first evidence on the atomic structure of the nucleation sites in the TiO2 anatase-to-rutile phase transition. Novel automated theoretical methods, namely stochastic surface walking based pathway sampling methods, are utilized to resolve the lowest energy pathways at the initial stage of phase transition. We show that among common anatase surfaces, only the (112) ridged surface provides the nucleation site for phase transition, which can lead to the formation of both TiO2-II and brookite thin slabs. The TiO2-II phase is kinetically preferred product; the propagation into the subsurface is still hindered by high barriers that is the origin for the slow kinetics of nuclei formation. The rutile nuclei are thus not rutile phase but nascent metastable TiO2-II phase in an anatase matrix. The phase transition kinetics is found to be sensitive to the compressive strain and the crystallographic directions. The results rationalize the size and morphology dependence of the anisotropic phase transition kinetics of anatase particles and could facilitate the rational design of material via controlled solid phase transition.

  11. Menopausal Symptoms and Sleep Quality During Menopausal Transition and Postmenopause

    Institute of Scientific and Technical Information of China (English)

    Jian-Ping Zhang; Yao-Qin Wang; Mei-Qin Yan; Zhao-Ai Li; Xiu-Ping Du; Xue-Qing Wu


    Background:Menopausal symptoms and sleep difficulty were physiological processes that were affected by genetic and other factors.This study was to investigate the prevalence of menopausal symptoms and sleep quality in menopausal transition (MT) and postmenopause (PM) women in Taiyuan,Shanxi.Methods:A community-based survey of women's menopausal symptoms and sleep quality was conducted between July 2012 and May 2013 at six municipal districts ofTaiyuan,Shanxi.A sample of 2429 women aged 40-59 years was divided into four groups:early MT,late MT,early PM,and late PM.Sleep quality in the past 2 weeks before the interview was recorded.The data were analyzed using SPSS 16.0.Results:The prevalence of menopausal symptoms was 49.8%.Mild,moderate,and severe symptoms were observed in 28.9%,18.5%,and 2.5% of participants,respectively.The highest prevalence of menopausal symptoms occurred in the early postmenopausal stage;the subsequences were the late postmenopausal stage and the early MT stage.Interestingly,among the 13 items of modified Kupperman index,the five most common symptoms were fatigue,arthralgia and myalgia,decreased libido,insomnia,and nervousness.Meanwhile,55% perimenopausal women had poor sleep.Conclusions:Menopausal symptoms are common but mild among women in Taiyuan,Shanxi during MT and PM.In these stages,the prevalence of poor sleep is high.

  12. Psychosexual Intervention in Patients With Stage I-III Gynecologic or Breast Cancer (United States)


    Ovarian Sarcoma; Ovarian Stromal Cancer; Stage I Uterine Sarcoma; Stage I Vaginal Cancer; Stage I Vulvar Cancer; Stage IA Cervical Cancer; Stage IA Endometrial Carcinoma; Stage IA Fallopian Tube Cancer; Stage IA Ovarian Epithelial Cancer; Stage IA Ovarian Germ Cell Tumor; Stage IA Primary Peritoneal Cavity Cancer; Stage IB Cervical Cancer; Stage IB Endometrial Carcinoma; Stage IB Fallopian Tube Cancer; Stage IB Ovarian Epithelial Cancer; Stage IB Ovarian Germ Cell Tumor; Stage IB Primary Peritoneal Cavity Cancer; Stage IC Fallopian Tube Cancer; Stage IC Ovarian Epithelial Cancer; Stage IC Ovarian Germ Cell Tumor; Stage IC Primary Peritoneal Cavity Cancer; Stage II Endometrial Carcinoma; Stage II Gestational Trophoblastic Tumor; Stage II Uterine Sarcoma; Stage II Vaginal Cancer; Stage II Vulvar Cancer; Stage IIA Cervical Cancer; Stage IIA Fallopian Tube Cancer; Stage IIA Ovarian Epithelial Cancer; Stage IIA Ovarian Germ Cell Tumor; Stage IIA Primary Peritoneal Cavity Cancer; Stage IIB Cervical Cancer; Stage IIB Fallopian Tube Cancer; Stage IIB Ovarian Epithelial Cancer; Stage IIB Ovarian Germ Cell Tumor; Stage IIB Primary Peritoneal Cavity Cancer; Stage IIC Fallopian Tube Cancer; Stage IIC Ovarian Epithelial Cancer; Stage IIC Ovarian Germ Cell Tumor; Stage IIC Primary Peritoneal Cavity Cancer; Stage III Gestational Trophoblastic Tumor; Stage III Uterine Sarcoma; Stage III Vaginal Cancer; Stage III Vulvar Cancer; Stage IIIA Cervical Cancer; Stage IIIA Endometrial Carcinoma; Stage IIIA Fallopian Tube Cancer; Stage IIIA Ovarian Epithelial Cancer; Stage IIIA Ovarian Germ Cell Tumor; Stage IIIA Primary Peritoneal Cavity Cancer; Stage IIIB Cervical Cancer; Stage IIIB Endometrial Carcinoma; Stage IIIB Fallopian Tube Cancer; Stage IIIB Ovarian Epithelial Cancer; Stage IIIB Ovarian Germ Cell Tumor; Stage IIIB Primary Peritoneal Cavity Cancer; Stage IIIC Endometrial Carcinoma; Stage IIIC Fallopian Tube Cancer; Stage IIIC Ovarian Epithelial Cancer; Stage IIIC Ovarian Germ Cell

  13. Lopsided dust rings in transition disks

    CERN Document Server

    Birnstiel, T; Pinilla, P


    Context. Particle trapping in local or global pressure maxima in protoplanetary disks is one of the new paradigms in the theory of the first stages of planet formation. However, finding observational evidence for this effect is not easy. Recent work suggests that the large ring-shaped outer disks observed in transition disk sources may in fact be lopsided and constitute large banana-shaped vortices. Aims. We wish to investigate how effective dust can accumulate along the azimuthal direction. We also want to find out if the size- sorting resulting from this can produce a detectable signatures at millimeter wavelengths. Methods. To keep the numerical cost under control we develop a 1+1D method in which the azimuthal variations are treated sepa- rately from the radial ones. The azimuthal structure is calculated analytically for a steady-state between mixing and azimuthal drift. We derive equilibration time scales and compare the analytical solutions to time-dependent numerical simulations. Results. We find that ...

  14. Data denial experiments for extratropical transition

    Directory of Open Access Journals (Sweden)

    Doris Anwender


    Full Text Available Data denial experiments using the European Centre for Medium-Range Weather Forecasts (ECMWF model are designed to investigate the value of targeted observations for historical extratropical transition (ET cases over the Atlantic. The impact of removing data from specified locations linked to the ET development is therefore examined. It is shown that the impact of denying data in the near tropical cyclone (TC environment is, on average, as important as denying data in mid-latitude sensitive regions determined using extratropical singular vectors (SV. The impact of data denial over TC regions propagates downstream from the Atlantic towards Europe, with a maximum degradation at day 4. This degradation is mainly attributed to the data denial at the TC stage, i.e. before ET is completed. When data are denied on mid-latitude sensitive regions, the largest degradation is found around day 2 and also after the day 4 forecast. In general, the loss of information content is larger when data are denied in mid-latitude sensitive areas because these identify dynamically active regions. In both denial experiments, aircraft and satellite radiance data are the most influential observations. For the selected case of Hurricane Irene, the largest degradations are found for forecasts initialised while Irene reached its peak intensity. If observations are denied in the near storm environment, the TC mostly disappears from the analysis and the subsequent forecast. This allows the impact of Irene on the formation of the downstream cut-off low to be investigated.

  15. Ring shaped dust accumulation in transition disks

    CERN Document Server

    Pinilla, P; Birnstiel, T


    Context.Transition disks are believed to be the final stages of protoplanetary disks, during which a forming planetary system or photoevaporation processes open a gap in the inner disk, drastically changing the disk structure. From theoretical arguments it is expected that dust growth, fragmentation and radial drift are strongly influenced by gas disk structure, and pressure bumps in disks have been suggested as key features that may allow grains to converge and grow efficiently. Aims. We want to study how the presence of a large planet in a disk influences the growth and radial distribution of dust grains, and how observable properties are linked to the mass of the planet. Methods. We combine two-dimensional hydrodynamical disk simulations of disk-planet interactions with state-of-the-art coagulation/fragmentation models to simulate the evolution of dust in a disk which has a gap created by a massive planet. We compute images at different wavelengths and illustrate our results using the example of the transi...

  16. Locomotor function in the early stage of Parkinson's disease. (United States)

    Carpinella, Ilaria; Crenna, Paolo; Calabrese, Elena; Rabuffetti, Marco; Mazzoleni, Paolo; Nemni, Raffaello; Ferrarin, Maurizio


    The cardinal motor symptoms of Parkinson's disease (PD) have been widely investigated with particular reference to abnormalities of steady-state walking. The great majority of studies, however are related to severe forms of PD patients (phases > = 3 of Hoehn and Yahr scale), where locomotor abnormalities are clearly manifested. Goal of the present study was to quantitatively describe locomotor symptoms in subjects with mild PD. Accordingly, a multitask protocol involving instrumental analysis of steady-state linear walking, initiation of gait, and turning while walking was applied to a group of patients with idiopathic PD in their early clinical stage (phases 1 and 2 of Hoehn and Yahr scale), as well as in age-matched elderly controls. Kinematic, kinetic, and myoelectric measures were obtained by optoelectronic motion analysis, force platform, and telemetric electromyography. Results in PD patients showed a tendency to bradykinetic gait, with reduction of walking speed and cadence. Impairments of gait initiation consisted in reduction of the backward shift of the center of pressure (CoP) and prolongation of the stepping phase. Alterations of the turning task were more consistent and included delayed reorientation of the head toward the new direction, altered head-upper trunk rotational strategy, and adoption of a greater number of steps to complete the turning. It is concluded that patients in the early stage of PD reveal mild alterations of steady-state linear walking and more significant anomalies in the transitional conditions, especially during changes in the travel direction. Quantitative analysis of nonstationary locomotor tasks might be a potentially useful starting point for further studies on the pathophysiology of PD.

  17. Investigation of Intellectual Risk-Taking Abilities of Students According to Piaget's Stages of Cognitive Development and Education Grade

    Directory of Open Access Journals (Sweden)

    Arzu Derya DAŞCI


    Full Text Available The purpose of this study is to determine the cognitive development stages of students of 4-8th class and is to research the effect to ability of intellectual risk-taking of this periods and education grade. Survey method and clinical method are used in the study which practices for this purpose. In the study which 20 students from every grade, in total 100 students, 6 different activities which are improved and used by different researchers are applied to determine the cognitive development stages whose classification is made by Piaget with Intellectual Risk-Taking and Predictor Scale which was improved by Beghetto (2009. Activities that students made individualistically are marked with observation form and their cognitive development stages are determined according to responses of each. Cognitive development stages and intellectual risk-taking level of students are analyzed with descriptive statistics. In the research result it is seen that majority of students is in the transitional stage and as long as class level increases it is passed to formal operational stage from concrete operational stage. While it is seen that as long as education grade rise intellectual risk-taking abilities of students decreases, it is determined that cognitive development stages has not any effect on this ability. The research is completed with suggestions based on results.

  18. Treatment results in women with clinical stage I and pathologic stage II endometrial carcinoma. (United States)

    Jobsen, J J; Schutter, E M; Meerwaldt, J H; Van Der Palen, J; Van Der Sijde, R; Ten Cate, L N


    The aim of this study is to report survival and results of therapy and possible prognostic factors in women with pathologic stage II endometrial carcinoma. Forty-two patients with pathologic stage II endometrial carcinoma were treated at the department of Radiation Oncology of the Medisch Spectrum Twente between 1987 and 1998. All patients received external radiotherapy following standard surgical procedures and no adjuvant systemic therapy was given. From the 42 patients 21 had a pathologic stage IIA and 21 stage IIB. The median follow-up was 62 months. The overall recurrence rate was 21.5% (9/42). Seven patients had distant metastasis, of which three also had locoregional recurrence, vaginal vault and/or pelvic. The presence of myometrial invasion (> (1/2)) and/or lymph-angioinvasion showed a significant relation with distant metastasis (P = 0.017). Stage IIB showed more recurrences, 33% (7/21). There was a significant different 5-year disease specific survival for stage IIA and IIB, respectively, 95% and 74% (P = 0.0311). Patients with a differentiation grade 3 and stage IIB showed a significantly poorer (P = 0.003) 5-year survival of 48.6% (P = 0.003). Results obtained in the present series of patients are in accordance with the literature. The present treatment policy seems justified, except for patients with pathologic stage IIB and grade 3, in which a more aggressive treatment should be considered.

  19. How orchestra members influence stage acoustic parameters on five different concert hall stages and orchestra pits. (United States)

    Wenmaekers, R H C; Hak, C C J M; Hornikx, M C J


    Stage acoustic parameters aim to quantify the amount of sound energy reflected by the stage and hall boundaries and the energy decay over time. In this research, the effect of orchestra presence on parameter values is investigated. The orchestra is simulated by dressed mannequins, which have been compared with humans with respect to acoustic properties. Impulse response measurements were performed in a concert hall, a theatre, a rehearsal room, and in two orchestra pits. Conditions were empty stage floors, stage floors with music stands and chairs only, and floors occupied by the mannequin orchestra. Results show that the direct and reflected sound levels and the energy decay are significantly affected by the orchestra compared to an empty stage or a stage with chairs and stands only. Both the direct sound and early reflected sound levels are reduced by the orchestra with the distance. The late reflected sound level is reduced considerably more than can be expected based on Barron's revised theory. It can be concluded that measurements on a stage without the orchestra being present results in significant differences. A practical method is presented to perform a "musician friendly" stage acoustic measurement with a real orchestra.

  20. The microorganisms in chronically infected end-stage and non-end-stage cystic fibrosis patients

    DEFF Research Database (Denmark)

    Rudkjøbing, Vibeke Børsholt; Thomsen, Trine Rolighed; Alhede, Morten;


    Patients suffering from cystic fibrosis (CF) develop chronic lung infections because of highly viscous mucus, where bacteria can form biofilms. In this study, we investigated the microorganisms present in the lungs of end-stage and non-end-stage patients using standard culturing techniques and mo...