WorldWideScience

Sample records for 12-30 ev range

  1. High efficiency multilayer gratings for monochromators in the energy range from 500 eV to 2500 eV

    Science.gov (United States)

    Lagarde, B.; Choueikani, F.; Capitanio, B.; Ohresser, P.; Meltchakov, E.; Delmotte, F.; Krumrey, M.; Polack, F.

    2013-03-01

    Multilayer (ML) gratings have been prepared by coating shallow ion etched lamellar gratings with a Mo2C/B4C multilayer having a layer thickness close to the groove depth. It was shown that such a structure behaves as a 2D synthetic crystal and can reach very high efficiencies when the Bragg condition is satisfied. A ML coated grating has been characterized at the SOLEIL Metrology beamline between 700 and 1700 eV and a beamline of PTB at BESSY II between 1750 and 3500 eV. A peak diffraction efficiency of nearly 27 % was measured at 2200 eV. The measured efficiencies are well reproduced by numerical simulations made with the electromagnetic propagation code CARPEM, This grating will be used in the Deimos beamline at SOLEIL together with a matched multilayer mirror.

  2. X-ray grating spectrometer for opacity measurements in the 50 eV to 250 eV spectral range at the LULI 2000 laser facilitya)

    Science.gov (United States)

    Reverdin, Charles; Thais, Frédéric; Loisel, Guillaume; Busquet, M.; Bastiani-Ceccotti, S.; Blenski, T.; Caillaud, T.; Ducret, J. E.; Foelsner, W.; Gilles, D.; Gilleron, F.; Pain, J. C.; Poirier, M.; Serres, F.; Silvert, V.; Soullie, G.; Turck-Chieze, S.; Villette, B.

    2012-10-01

    An x-ray grating spectrometer was built in order to measure opacities in the 50 eV to 250 eV spectral range with an average spectral resolution ⟨E/δE⟩ ˜ 50. It has been used at the LULI-2000 laser facility at École Polytechnique (France) to measure the Δn = 0, n = 3 transitions of several elements with neighboring atomic number: Cr, Fe, Ni, and Cu in the same experimental conditions. Hence a spectrometer with a wide spectral range is required. This spectrometer features one line of sight looking through a heated sample at backlighter emission. It is outfitted with one toroidal condensing mirror and several flat mirrors cutting off higher energy photons. The spectral dispersion is obtained with a flatfield grating. Detection consists of a streak camera sensitive to soft x-ray radiation. Some experimental results showing the performance of this spectrometer are presented.

  3. X-ray grating spectrometer for opacity measurements in the 50 eV to 250 eV spectral range at the LULI 2000 laser facility

    Energy Technology Data Exchange (ETDEWEB)

    Reverdin, Charles; Caillaud, T.; Gilleron, F.; Pain, J. C.; Silvert, V.; Soullie, G.; Villette, B. [CEA, DAM, DIF, 91297 Arpajon (France); Thais, Frederic; Loisel, Guillaume; Blenski, T.; Poirier, M. [CEA, DSM, IRAMIS, Service Photons, Atomes et Molecules, 91191 Gif-sur-Yvette (France); Busquet, M. [ARTEP Inc, Ellicott City, Maryland 21042 (United States); Bastiani-Ceccotti, S.; Serres, F. [LULI, Ecole Polytechnique, CNRS, CEA, UPMC, route de Saclay, 91128 Palaiseau (France); Ducret, J. E. [CELIA, UMR5107, CEA, CNRS, Universite de Bordeaux, 33400 Talence (France); Foelsner, W. [Max Planck Instituet fuer Quantum Optik, 85748 Garching (Germany); Gilles, D.; Turck-Chieze, S. [CEA, DSM, IRFU, Service d' astrophysique, 91191 Gif-sur-Yvette (France)

    2012-10-15

    An x-ray grating spectrometer was built in order to measure opacities in the 50 eV to 250 eV spectral range with an average spectral resolution {approx} 50. It has been used at the LULI-2000 laser facility at Ecole Polytechnique (France) to measure the {Delta}n = 0, n = 3 transitions of several elements with neighboring atomic number: Cr, Fe, Ni, and Cu in the same experimental conditions. Hence a spectrometer with a wide spectral range is required. This spectrometer features one line of sight looking through a heated sample at backlighter emission. It is outfitted with one toroidal condensing mirror and several flat mirrors cutting off higher energy photons. The spectral dispersion is obtained with a flatfield grating. Detection consists of a streak camera sensitive to soft x-ray radiation. Some experimental results showing the performance of this spectrometer are presented.

  4. X-ray grating spectrometer for opacity measurements in the 50 eV to 250 eV spectral range at the LULI 2000 laser facility.

    Science.gov (United States)

    Reverdin, Charles; Thais, Frédéric; Loisel, Guillaume; Busquet, M; Bastiani-Ceccotti, S; Blenski, T; Caillaud, T; Ducret, J E; Foelsner, W; Gilles, D; Gilleron, F; Pain, J C; Poirier, M; Serres, F; Silvert, V; Soullie, G; Turck-Chieze, S; Villette, B

    2012-10-01

    An x-ray grating spectrometer was built in order to measure opacities in the 50 eV to 250 eV spectral range with an average spectral resolution ∼ 50. It has been used at the LULI-2000 laser facility at École Polytechnique (France) to measure the Δn = 0, n = 3 transitions of several elements with neighboring atomic number: Cr, Fe, Ni, and Cu in the same experimental conditions. Hence a spectrometer with a wide spectral range is required. This spectrometer features one line of sight looking through a heated sample at backlighter emission. It is outfitted with one toroidal condensing mirror and several flat mirrors cutting off higher energy photons. The spectral dispersion is obtained with a flatfield grating. Detection consists of a streak camera sensitive to soft x-ray radiation. Some experimental results showing the performance of this spectrometer are presented. PMID:23126955

  5. Calibrating image plate sensitivity in the 700 to 5000 eV spectral energy range

    Science.gov (United States)

    Haugh, Michael J.; Lee, Joshua; Romano, Edward; Schneider, Marilyn

    2013-09-01

    This paper describes a method to calibrate image plate sensitivity for use in the low energy spectral range. Image plates, also known as photostimulable luminescence (PSL) detectors, have often proved to be a valuable tool as a detector for plasma physics studies. Their advantages of large dynamic range, high stopping power, and resistance to neutron damage sometimes outweigh the problems of limited resolution and the remote processing required. The neutron damage resistance is required when the X-ray source is producing a high neutron flux. The Static X-ray Imager (SXI) is a key diagnostic on the National Ignition Facility (NIF) target chamber at LLNL for use in determining the symmetry of the laser beams. The SXI is essential to proper interpretation of the data from the Dante diagnostic to determine the X-ray radiation temperature. It is comprised of two diagnostics located at the top and the bottom of the target chamber. The usual detector is a large array CCD camera. For shots giving high yields of neutrons, the camera would not only be blinded by the neutrons, it would be damaged. To get around this problem, an image plate (IP) is used as the detector. The NIF application covers the energy range from 700 to 5000 eV. The type of image plates typically used for plasma physics are the Fuji BAS-MS, BAS-SR, and BAS-TR models. All models consist of an X-ray sensitive material made of BaF(Br,I):Eu2+ embedded in a plastic binder. X-rays incident on the phosphor ionize the Eu 2+ producing Eu3+ and free electrons that are trapped in lattice defects (F-centers) produced by the absence of halogen ions in the BaF2 crystal. An image plate readout scanner irradiates the IP with a red laser causing reduction of the Eu3+ and emission of a blue photon. The photon is collected using a photomultiplier and digitized to make an electronic image. Image plates are cleared of all F-centers by putting them under a bright light for about 10 minutes. They are then ready for producing a

  6. DNA strand breaks and crosslinks induced by transient anions in the range 2-20 eV

    Energy Technology Data Exchange (ETDEWEB)

    Luo, Xinglan; Zheng, Yi, E-mail: Yizheng@fzu.edu.cn [Research Institute of Photocatalysis, State Key Laboratory of Photocatalysis on Energy and Environment, Fuzhou University, Fuzhou 350002 (China); Sanche, Léon [Group in the Radiation Sciences, Faculty of Medicine, Université de Sherbrooke, Sherbrooke, Quebec J1H 5N4 (Canada)

    2014-04-21

    The energy dependence of the yields of single and double strand breaks (SSB and DSB) and crosslinks induced by electron impact on plasmid DNA films is measured in the 2-20 eV range. The yield functions exhibit two strong maxima, which are interpreted to result from the formation of core-excited resonances (i.e., transient anions) of the bases, and their decay into the autoionization channel, resulting in π → π{sup *} electronic transitions of the bases followed by electron transfer to the C–O σ{sup *} bond in the phosphate group. Occupancy of the σ{sup *} orbital ruptures the C–O bond of the backbone via dissociative electron attachment, producing a SSB. From a comparison of our results with those of other works, including theoretical calculations and electron-energy-loss spectra of the bases, the 4.6 eV peak in the SSB yield function is attributed to the resonance decay into the lowest electronically excited states of the bases; in particular, those resulting from the transitions 1{sup 3}A{sup ′} (π{sub 2} → π{sub 3}{sup *}) and 1{sup 3}A{sup ″} (n{sub 2} → π{sub 3}{sup *}) of thymine and 1{sup 3}A{sup ′} (π → π{sup *}) of cytosine. The strongest peak at 9.6 eV in the SSB yield function is also associated with electron captured by excited states of the bases, resulting mostly from a multitude of higher-energy π → π{sup *} transitions. The DSB yield function exhibits strong maxima at 6.1 and 9.6 eV. The peak at 9.6 eV is probably related to the same resonance manifold as that leading to SSB, but the other at 6.1 eV may be more restricted to decay into the electronic state 1{sup 3}A{sup ′} (π → π{sup *}) of cytosine via autoionization. The yield function of crosslinks is dominated by a broad peak extending over the 3.6-11.6 eV range with a sharper one at 17.6 eV. The different line shape of the latter function, compared to that of SSB and DSB, appears to be due to the formation of reactive radical sites in the initial supercoiled

  7. Ellipsometry and energy characterization of the electron impact polymerization in the range 0-20 eV

    Science.gov (United States)

    Zyn, V. I.

    2016-05-01

    The electron impact polymerization of adsorbed vapors of a hydrocarbon vacuum oil with molecular mass 450 Da (C32H66) has been studied in-situ in the range 0-20 eV using ellipsometry and a servo system with the Kelvin's vibrating probe. This allowed registering at the same time the two energy-dependent characteristics (spectra) of the process: the film growth rate and the electrical potential of the irradiated surface. The first spectrum has two resonance maxima near 2.5 and 9.5 eV while the surface potential has only one weak extremum near 9.5 eV. The first growth rate peak at 2.5 eV was connected with a creation of radicals through a resonant process of the dissociative electron attachment and beginning polymerization. The peaks at 9.5 eV in both the spectra mean accelerating polymerization and decreasing surface charge owing to simultaneous birth of highly active radicals and free electrons. The single resonant process controlling both the processes simultaneously is the dissociative attachment of an electron to an anti-bonding molecular orbital, almost the same as at the 2.5 eV but differing by deeper decomposition of the transient anion, among the products of which are now not the radicals only but also free electrons. The kinetic curves obtained in pulsed regimes of the electron bombardment were qualitatively identical for different precursors and were used for calculations of cross sections of these processes.

  8. Energy dependence of some neutron dosimeter sensitivities in the 1 ev up to 4 kev energy range

    International Nuclear Information System (INIS)

    The sensitivities of DN-A-1 device and SNM-14 slow neutron counter with a combined moderator in the 1 eV up to 4 keV energy range has been experimentally determined. The IBR-30 reactor served as a neutron source, spectral distribution was performed by the time-of-flight method. The sensitivity constancy of a long counter in the 1 eV up to 4 keV energy range has been experimentally shown. The obtained sensitivity values and other data available could be used in determining energy dependencies of the device sensitivity in essential neutron energy range. It permits to evaluate their errors when using as dosimeters in radiation fields of nuclear physics installations

  9. Fragmentation of isoxazole molecules by electron impact in the energy range 10-85 eV

    Science.gov (United States)

    Linert, Ireneusz; Lachowicz, Izabela; Wasowicz, Tomasz J.; Zubek, Mariusz

    2010-09-01

    Fragmentation of isoxazole molecules by electron impact excitation, that produces excited atomic and molecular fragments, has been studied using the optical excitation technique. Excited hydrogen atoms H( n), n = 4-7, have been detected by observation of the H β to H ɛ lines of the Balmer series. The diatomic CH(A 2Δ) and CN(B 2Σ +) fragments have been identified by their A 2Δ → X 2Π r and B 2Σ + → X 2Σ + emission bands, respectively. The appearance energies for the H( n = 4), CH(A 2Δ) and CN(B 2Σ +) have been measured to be 21.9, 14.0 and 10.6 eV, respectively. Absolute emission cross sections have been also obtained for the fragments in electron energy ranges from their respective appearance thresholds up to 85 eV. Possible fragmentation processes are discussed.

  10. VUV action spectroscopy of protonated leucine-enkephalin peptide in the 6-14 eV range

    Energy Technology Data Exchange (ETDEWEB)

    Ranković, M. Lj. [Institute of Physics Belgrade, University of Belgrade, Pregrevica 118, 11080 Belgrade (Serbia); Canon, F. [INRA, UMR1324 Centre des Sciences du Goût et de l’Alimentation, F-21000 Dijon (France); Nahon, L. [SOLEIL, l’Orme des Merisiers, St Aubin, BP48, 91192 Gif sur Yvette Cedex (France); Giuliani, A. [SOLEIL, l’Orme des Merisiers, St Aubin, BP48, 91192 Gif sur Yvette Cedex (France); INRA, UAR1008, CEPIA, Rue de la Géraudière, BP 71627, 44316 Nantes (France); Milosavljević, A. R., E-mail: vraz@ipb.ac.rs [Institute of Physics Belgrade, University of Belgrade, Pregrevica 118, 11080 Belgrade (Serbia); Radiation Laboratory, University of Notre Dame, Notre Dame, Indiana 46556 (United States)

    2015-12-28

    We have studied the Vacuum Ultraviolet (VUV) photodissociation of gas-phase protonated leucine-enkephalin peptide ion in the 5.7 to 14 eV photon energy range by coupling a linear quadrupole ion trap with a synchrotron radiation source. We report VUV activation tandem mass spectra at 6.7, 8.4, and 12.8 eV photon energies and photodissociation yields for a number of selected fragments. The obtained results provide insight into both near VUV radiation damage and electronic properties of a model peptide. We could distinguish several absorption bands and assign them to particular electronic transitions, according to previous theoretical studies. The photodissociation yields appear to be very different for the various observed fragmentation channels, depending on both the types of fragments and their position along the peptide backbone. The present results are discussed in light of recent gas-phase spectroscopic data on peptides.

  11. 19 CFR 12.30 - Whaling.

    Science.gov (United States)

    2010-04-01

    ...)), or of any regulation issued under the Act (50 CFR part 351) is unlawful. Customs officers and... 19 Customs Duties 1 2010-04-01 2010-04-01 false Whaling. 12.30 Section 12.30 Customs Duties U.S... OF MERCHANDISE Wild Animals, Birds, and Insects § 12.30 Whaling. The importation and exportation...

  12. A First Preliminary Look: Are Corridor Charging Stations Used to Extend the Range of Electric Vehicles in The EV Project?

    Energy Technology Data Exchange (ETDEWEB)

    John Smart

    2013-01-01

    A preliminary analysis of data from The EV Project was performed to begin answering the question: are corridor charging stations used to extend the range of electric vehicles? Data analyzed were collected from Blink brand electric vehicle supply equipment (EVSE) units based in California, Washington, and Oregon. Analysis was performed on data logged between October 1, 2012 and January 1, 2013. It should be noted that as additional AC Level 2 EVSE and DC fast chargers are deployed, and as drivers become more familiar with the use of public charging infrastructure, future analysis may have dissimilar conclusions.

  13. A-periodic multilayer development for attosecond pulses in the 300-500 eV photon energy range

    Energy Technology Data Exchange (ETDEWEB)

    Guggenmos, Alexander; Hofstetter, Michael; Kleineberg, Ulf [Fakultaet fuer Physik, Ludwig-Maximilians-Universitaet Muenchen, Garching (Germany); Max-Planck-Institut fuer Quantenoptik, Garching (Germany); Rauhut, Roman [Fakultaet fuer Physik, Ludwig-Maximilians-Universitaet Muenchen, Garching (Germany)

    2011-07-01

    The development of ultrafast X-ray pulses in the sub-femtosecond time regime is a cutting edge technology for studying electron dynamics in atoms, molecules or solid surfaces/nanostructures by means of pump/probe electron spectroscopy. XUV elements as multilayer mirrors and thin metal filters are used to filter and shape attosecond bursts from high harmonic radiation. One near future goal is to extend the current technology to higher photon energies, reaching the water window range around 300-500 eV, where the in-vitro investigation of bio-materials on ultra-short time scales becomes possible. Following the ideas of nowadays experimental setups, both the spectral and the temporal resolution can be determined and guided by means of periodic and a-periodic multilayer mirrors, allowing for spectral and temporal soft X-ray pulse shaping. We will present first investigations of periodic and a-periodic multilayer XUV optics in that energy range of 300-400 eV and discuss their applications for filtering single attosecond pulses from High Harmonic radiation. Simulations and optimizations of various binary and ternary multilayer material systems as well as first experimental results achieved by Ion Beam Deposition and in-situ ellipsometry of the deposited nanolayers are demonstrated.

  14. Changes of the cosmic-ray mass composition in the 10 14-10 16 eV energy range

    Science.gov (United States)

    Bernlöhr, K.; Hofmann, W.; Leffers, G.; Matheis, V.; Panter, M.; Zink, R.

    1998-04-01

    Data taken with ten Cosmic Ray Tracking (CRT) detectors and the HEGRA air-shower array on La Palma, Canary Islands, have been analysed to investigate changes of the cosmic overlineray mass composition at the 'knee' of the cosmic-ray flux spectrum near 10 15 eV energy. The analysis is based on the angular distributions of particles in air showers. HEGRA data provided the shower size, direction, and core position and CRT data the particle track information. It is shown that the angular distribution of muons in air showers is sensitive to the composition over a wide range of shower sizes and, thus, primary cosmic-ray energies with little systematic uncertainties. Results can be easily expressed in terms of of primary cosmic rays. In the lower part of the energy range covered, we have considerable overlap with direct composition measurements by the JACEE collaboration and find compatible results in the observed rise of . Above about 10 15 eV energy we find no or at most a slow further rise of . Simple cosmic-ray composition models are presented which are fully consistent with our results as well as the JACEE flux and composition measurements and the flux measurements of the Tibet ASγ collaboration. Minimal three-parameter composition models defined by the same power-law slope of all elements below the knee and a common change in slope at a fixed rigidity are inconsistent with these data.

  15. Design of a polarised light beamline in the energy range of 30-4000 eV

    CERN Document Server

    Chaudhari, S M; Phase, D M; Dasannacharya, B A

    2003-01-01

    This article describes the design of a possible polarised light beamline for magnetic circular dichroism and photoemission experiments on a bending magnet source of 2.5 GeV storage ring, Indus-2. It will have an energy range of 30-4000 eV and will deliver circular as well as linearly polarised light to perform absorption and photoemission experiments covering relevant L and M edges of most of the elements. The beamline optics consists of a vertically moveable aperture for polarisation selection. It has three spherical gratings and a double crystal monochromator necessary for energy selection in low and high-energy ranges respectively. Corresponding pre- and post-mirror optics, which is common for both the monochromators is the highlight of this design. Detailed ray-tracing calculations, which were carried out to evaluate and optimise the performance of the proposed beamline, are presented in this article.

  16. Optical constants of magnetron-sputtered boron carbide thin films from photoabsorption data in the range 30 to 770 eV.

    Science.gov (United States)

    Soufli, Regina; Aquila, Andrew L; Salmassi, Farhad; Fernández-Perea, Mónica; Gullikson, Eric M

    2008-09-01

    This work discusses the experimental determination of the optical constants (refractive index) of DC-magnetron-sputtered boron carbide films in the 30-770 eV photon energy range. Transmittance measurements of three boron carbide films with thicknesses of 54.2, 79.0, and 112.5 nm were performed for this purpose. These are believed to be the first published experimental data for the refractive index of boron carbide films in the photon energy range above 160 eV and for the near-edge x-ray absorption fine structure regions around the boron K (188 eV), carbon K (284.2 eV), and oxygen K (543.1 eV) absorption edges. The density, composition, surface chemistry, and morphology of the films were also investigated using Rutherford backscattering, x-ray photoelectron spectroscopy, atomic force microscopy, scanning electron microscopy, and extreme ultraviolet reflectance measurements.

  17. DEIMOS: A beamline dedicated to dichroism measurements in the 350–2500 eV energy range

    Energy Technology Data Exchange (ETDEWEB)

    Ohresser, P., E-mail: philippe.ohresser@synchrotron-soleil.fr; Otero, E.; Choueikani, F.; Chen, K.; Stanescu, S.; Deschamps, F.; Moreno, T.; Polack, F.; Lagarde, B.; Daguerre, J.-P.; Marteau, F. [Synchrotron SOLEIL, L’Orme des Merisiers, Saint-Aubin - BP 48, 91192 Gif-sur-Yvette (France); Scheurer, F.; Joly, L.; Muller, B. [Institut de Physique et Chimie des Matériaux de Strasbourg, UMR 7504 UdS-CNRS, 67034 Strasbourg Cedex 2 (France); Kappler, J.-P. [Synchrotron SOLEIL, L’Orme des Merisiers, Saint-Aubin - BP 48, 91192 Gif-sur-Yvette (France); Institut de Physique et Chimie des Matériaux de Strasbourg, UMR 7504 UdS-CNRS, 67034 Strasbourg Cedex 2 (France); Bunau, O.; Sainctavit, Ph. [Synchrotron SOLEIL, L’Orme des Merisiers, Saint-Aubin - BP 48, 91192 Gif-sur-Yvette (France); Institut de Minéralogie et de Physique des Milieux Condensés, CNRS UMR 7590, Université Pierre et Marie Curie, 75252 Paris Cedex 5 (France)

    2014-01-15

    The DEIMOS (Dichroism Experimental Installation for Magneto-Optical Spectroscopy) beamline was part of the second phase of the beamline development at French Synchrotron SOLEIL (Source Optimisée de Lumière à Energie Intermédiaire du LURE) and opened to users in March 2011. It delivers polarized soft x-rays to perform x-ray absorption spectroscopy, x-ray magnetic circular dichroism, and x-ray linear dichroism in the energy range 350–2500 eV. The beamline has been optimized for stability and reproducibility in terms of photon flux and photon energy. The main end-station consists in a cryo-magnet with 2 split coils providing a 7 T magnetic field along the beam or 2 T perpendicular to the beam with a controllable temperature on the sample from 370 K down to 1.5 K.

  18. Collision Cross Sections for O + Ar(+) Collisions in the Energy Range 0.03-500 eV.

    Science.gov (United States)

    Sycheva, A A; Balint-Kurti, G G; Palov, A P

    2016-07-14

    The interatomic potentials of the a(2)Π and b(2)Π states of the OAr(+) molecule are calculated using the relativistic complete-active space Hartree-Fock method followed by a multireference configuration interaction calculation with an aug-cc-pwCVNZ-DK basis sets where N is 4 and 5. The calculations were followed by an extrapolation to the complete basis set limit. An avoided crossing between the two potential energy curves is found at an internuclear separation of 5.75 bohr (3.04 Å). As the transition probability between the curves is negligible in the relative collision energy range 0.03-500 eV of interest here, collisions on the lower adiabatic a(2)Π potential may be treated without reference to the upper state. For low energies and orbital angular momentum quantum numbers, the one-dimensional radial Schrödinger equation is solved numerically using a Numerov algorithm method to determine the phase shift. The semiclassical JWKB approximation was employed for relative energies greater than 5 eV and orbital angular quantum numbers higher than 500. Differential, integral, transport (diffusion), and viscosity cross sections for elastic collisions of oxygen atoms with argon ions are calculated for the first time for the range of relative collision energies studied. The calculated cross sections are expected to be of utility in the fields of nanotechnology and arc welding. The combination of an Ar(+)((2)P) ion and a O((3)P) atom gives rise to a total of 12 different molecular electronic states that are all coupled by spin-orbit interactions. Potential energy curves for all 12 states are computed at the complete active space self-consistent field (CASSCF) level and scattering calculations performed. The results are compared with those obtained using just the lowest potential energy curve. PMID:26741565

  19. Collision Cross Sections for O + Ar(+) Collisions in the Energy Range 0.03-500 eV.

    Science.gov (United States)

    Sycheva, A A; Balint-Kurti, G G; Palov, A P

    2016-07-14

    The interatomic potentials of the a(2)Π and b(2)Π states of the OAr(+) molecule are calculated using the relativistic complete-active space Hartree-Fock method followed by a multireference configuration interaction calculation with an aug-cc-pwCVNZ-DK basis sets where N is 4 and 5. The calculations were followed by an extrapolation to the complete basis set limit. An avoided crossing between the two potential energy curves is found at an internuclear separation of 5.75 bohr (3.04 Å). As the transition probability between the curves is negligible in the relative collision energy range 0.03-500 eV of interest here, collisions on the lower adiabatic a(2)Π potential may be treated without reference to the upper state. For low energies and orbital angular momentum quantum numbers, the one-dimensional radial Schrödinger equation is solved numerically using a Numerov algorithm method to determine the phase shift. The semiclassical JWKB approximation was employed for relative energies greater than 5 eV and orbital angular quantum numbers higher than 500. Differential, integral, transport (diffusion), and viscosity cross sections for elastic collisions of oxygen atoms with argon ions are calculated for the first time for the range of relative collision energies studied. The calculated cross sections are expected to be of utility in the fields of nanotechnology and arc welding. The combination of an Ar(+)((2)P) ion and a O((3)P) atom gives rise to a total of 12 different molecular electronic states that are all coupled by spin-orbit interactions. Potential energy curves for all 12 states are computed at the complete active space self-consistent field (CASSCF) level and scattering calculations performed. The results are compared with those obtained using just the lowest potential energy curve.

  20. Change of primary cosmic radiation nuclear composition in the energy range 10^{15} - 10^{17} eV

    CERN Document Server

    Barnaveli, A T; Chubenko, A P; Eristavi, N A; Khaldeeva, I V; Nesterova, N M; Verbetsky, Yu G; Verbetsky, Yu.G.

    2002-01-01

    The dependence E_h (N_e) of Extensive Air Shower (EAS) hadronic component energy flux on the number N_e of particles in EAS is investigated in the primary energy range of the order of 10^{15} - 10^{17} eV. The work was aimed at checking the existence of irregularities of E_h (N_e)/N_e behavior at these energies in several independent experiments. The investigation is carried out using large statistical material obtained at different configurations of experimental apparatus and under different triggering conditions. The existence of irregularities of E_h (N_e)/N_e behavior in the region Ne > 2*10^6 is confirmed. These irregularities have the character of sharp deeps and are located near the same values of N_e regardless of the experimental material and selection conditions used. So, at recent stage of research the existence of these irregularities of E_h (N_e)/N_e behavior in the range of N_e > 2*10^6 may be regarded as reliably established. This fact supports our earlier conclusion on the existence of primary...

  1. Apparatus for In Situ X-Ray Absorption Fine Structure Studies on Catalytic Systems in the Energy Range 1000 eV

    NARCIS (Netherlands)

    Koningsberger, D.C.; Eerden, A.M.J. van der; Bokhoven, J.A. van; Smith, A.D.

    2000-01-01

    A new apparatus for in situ x-ray absoprtion fine structure measurements in the medium energy range of 1000–3500 eV has been developed. Measurements can be performed in a gaseous environment (max. pressure 1 bar) at temperatures ranging from 80 to 750 K. Pre-treatments can be performed at 5 bar and

  2. Yakutsk array radio emission registration results in the energy range of 3*10^16-5*10^18 eV

    CERN Document Server

    Petrov, I; Petrov, Z; Kozlov, V; Pravdin, M

    2013-01-01

    This paper presents the set of measurements of ultra-high energy air shower radio emission at frequency 32 MHz in period of 2008-2012. The showers are selected by geomagnetic and azimuth angles and then by the energy in three intervals: 3*10^16 3*10^17 eV, 3*10^17 6*10^17 eV and 6*10^17 5*10^18 eV. In each energy interval average lateral distribution function using mathematically averaged data from antennas with di?fferent directions are plotted. In the paper, using experimental data the dependence of radio signal averaged amplitude from geomagnetic angle, the shower axis distance and the energy are determined. Depth of maximum of cosmic ray showers Xmax for the given energy range is evaluated. The evaluation is made according QGSJET model calculations and average lateral distribution function shape.

  3. Guided-ion beam measurements of Ar+ + Ar symmetric charge-transfer cross sections at ion energies ranging from 0.2 to 300 eV

    International Nuclear Information System (INIS)

    Guided-ion beam (GIB) measurements of the Ar+ + Ar symmetric charge-transfer (SCT) system are presented for ion energies ranging from 0.2 to 300 eV. Two methods are applied to distinguish primary and secondary ions: (i) based on isotopic-labeling, (ii) based on significant laboratory velocity differences. The absolute cross sections measured with these methods are in excellent agreement at energies above 1 eV. The experimental results are compared with semi-classical calculations performed with various published Ar2+ potentials. The calculations including spin-orbit effects lie within 10% of the isotope-selected and attenuation measurements at all investigated ion energies. The present results lie significantly above the simple Rapp and Francis model. Important errors in the latter approach are pointed out and a correct one-electron model is proposed. First measurements of the differential cross section at 0.5 eV collision energy are briefly mentioned. (orig.)

  4. Experimental Search for Hidden Photon CDM in the eV mass range with a Dish Antenna

    CERN Document Server

    Suzuki, J; Inoue, Y; Minowa, M

    2015-01-01

    A search for hidden photon cold dark matter (HP CDM) using a new technique with a dish antenna is reported. From the result of the measurement, we found no evidence for the existence of HP CDM and set an upper limit on the photon-HP mixing parameter $\\chi$ of $\\sim 6\\times 10^{-12}$ for the hidden photon mass $m_\\gamma = 3.1 \\pm 1.2$ eV.

  5. Experimental search for hidden photon CDM in the eV mass range with a dish antenna

    Energy Technology Data Exchange (ETDEWEB)

    Suzuki, J.; Horie, T. [Department of Physics, School of Science, The University of Tokyo,7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033 (Japan); Inoue, Y. [International Center for Elementary Particle Physics, The University of Tokyo,7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033 (Japan); Minowa, M. [Department of Physics, School of Science, The University of Tokyo,7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033 (Japan); Research Center for the Early Universe (RESCEU), School of Science,The University of Tokyo,7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033 (Japan)

    2015-09-15

    A search for hidden photon cold dark matter (HP CDM) using a new technique with a dish antenna is reported. From the result of the measurement, we found no evidence for the existence of HP CDM and set an upper limit on the photon-HP mixing parameter χ of ∼6×10{sup −12} for the hidden photon mass m{sub γ}=3.1±1.2 eV.

  6. Ionic fragmentation of the isoprene molecule in the VUV energy range (12 to 310 eV)

    Energy Technology Data Exchange (ETDEWEB)

    Bernini, R.B., E-mail: rafael.bernini@ifrj.edu.br [Instituto Federal de Ciência e Tecnologia do Rio de Janeiro (IFRJ), 25050-100 Duque de Caxias, RJ (Brazil); Coutinho, L.H. [Instituto de Física, Universidade Federal do Rio De Janeiro (UFRJ), 21941-972 Rio de Janeiro, RJ (Brazil); Nunez, C.V. [Laboratório de Bioprospecção e Biotecnologia, Coordenação de Tecnologia e Inovação, Instituto Nacional de Pesquisas da Amazônia (INPA), 69060-001 Manaus, AM (Brazil); Castilho, R.B. de [Departamento de Química, Instituto de Ciências Exatas, Universidade Federal do Amazonas (UFAM), 69077-000 Manaus, AM (Brazil); Souza, G.G.B. de [Instituto de Química, Universidade Federal do Rio de Janeiro (UFRJ), 21949-900 Rio de Janeiro, RJ (Brazil)

    2015-07-15

    Highlights: • Ionic fragmentation of isoprene following valence-shell and C 1s excitation. • Experimental observation of single and double ionization processes. • Large increase in fragmentation following core excitation. • Similar dissociation pattern bellow (270 eV) and above (310 eV) core edge. • Stable molecular ion observed at all photon energies. - Abstract: Isoprene, C{sub 5}H{sub 8}, is a biogenic volatile compound emitted from plants and animals, playing an important role in atmospheric chemistry. In this work, we have studied the ionic fragmentation of the isoprene molecule induced by high energy photons (synchrotron radiation), both at the valence (12.0, 14.0, 16.0, 18.0, and 21.0 eV) and carbon 1s edge (270 and 310 eV, respectively, below and above edge) energies. The ionic fragments were mass-analyzed using a Wiley–McLaren time-of-flight spectrometer (TOF) and single (PEPICO) and double ionization coincidence (PEPIPICO) spectra were obtained. As expected, the fragmentation degree increases with increasing energy. Below and above the carbon 1s edge, the fragmentation patterns are quite similar, and basically the same fragments are observed as compared to the spectra following valence-shell ionization. Stable doubly-charged ions were not observed. A PEPIPICO spectrum has shown that the main dissociation route for doubly-ionized species corresponds to the [CH{sub 3}]{sup +}/[C{sub 4}H{sub 2–5}]{sup +} ion pair. Intense fragmentation of the isoprene molecule has been observed following valence shell and core electron ionization. The observance of basically the same fragments when moving from valence to inner-shell suggests that basically the same fragmentation routes are present in both cases. All doubly (or multiply)-charged cations are unstable, at least on a microsecond scale.

  7. Characterisation of a TES-Based X-ray Microcalorimeter in the Energy Range from 150 to 1800 eV Using an Adiabatic Demagnetisation Refrigerator

    Science.gov (United States)

    Gottardi, L.; Takei, Y.; van der Kuur, J.; de Korte, P. A. J.; Hoevers, H. F. C.; Boersma, D.; Bruijn, M.; Mels, W.; Ridder, M. L.; Takken, D.; van Weers, H.

    2008-04-01

    We characterised a TES-based X-ray microcalorimeter in an adiabatic demagnetisation refrigerator (ADR) using synchrotron radiation. The detector response and energy resolution was measured at the beam-line in the PTB radiometry laboratory at the electron storage ring BESSY II in the range from 200 to 1800 eV. We present and discuss the results of the energy resolution measurements as a function of energy, beam intensity and detector working point. The measured energy resolution ranges between 1.5 to 2.1 eV in the investigated energy range and is weakly dependent on the detector set point. A first analysis shows a count-rate capability, without considerable loss of performance, of about 500 counts per second.

  8. Characterisation of a TES-Based X-ray Microcalorimeter in the Energy Range from 150 to 1800 eV Using an Adiabatic Demagnetisation Refrigerator

    CERN Document Server

    Gottardi, Luciano; van der Kuur, Jan; de Korte, Piet A J; Hoevers, Henk F C; Boersma, Dirk; Bruijn, Marcel; Mels, Wim; Ridder, Marcel L; Takken, Dick; van Weers, Henk

    2016-01-01

    We characterised a TES-based X-ray microcalorimeter in an adiabatic demagnetisation refrigerator (ADR) using synchrotron radiation. The detector response and energy resolution was measured at the beam-line in the PTB radiometry laboratory at the electron storage ring BESSY II in the range from 200 to 1800 eV. We present and discuss the results of the energy resolution measurements as a function of energy, beam intensity and detector working point. The measured energy resolution ranges between 1.5 to 2.1 eV in the investigated energy range and is weakly dependent on the detector set point. A first analysis shows a count-rate capability, without considerable loss of performance, of about 500 counts per second.

  9. Photoion mass spectrometry of five amino acids in the 6-22 eV photon energy range

    Energy Technology Data Exchange (ETDEWEB)

    Jochims, Hans-Werner; Schwell, Martin; Chotin, Jean-Louis; Clemino, Monique; Dulieu, Francois; Baumgaertel, Helmut; Leach, Sydney

    2004-03-08

    A photoionization mass spectrometry study in the 6-22 eV photon energy region of five amino acids, glycine-h{sub 5} and its -d{sub 5} isotopologue, {alpha}-alanine, {beta}-alanine, {alpha}-aminoisobutyric acid and {alpha}-valine, revealed VUV-induced degradation pathways of these important biological molecules. The fragmentation patterns, ionization energies and ion appearance energies are reported, many for the first time, and are compared with results of electron impact and other studies. Assignment of ion peaks and determination of fragment ion formation channels were assisted by mass spectral data on deuterated isotopologues of the three proteinaceous amino acids studied. Thermochemical data, coupled with the observed ion appearance energies, was also useful in clarifying dissociative photoionization pathways. Ion pair formation appears to occur in certain low energy dissociation processes. Isomeric interconversion between {alpha}-alanine and {beta}-alanine cations does not occur up to 20 eV excitation energy. Some astrophysical implications concerning the prospects for amino acid observation and survival in the interstellar medium and in meteorites are briefly discussed.

  10. Positron total cross sections for collisions with O2, H2O and CH4 in energy range from 30 to 3000eV

    Institute of Scientific and Technical Information of China (English)

    Shi De-Heng; Liu Yu-Fang; Sun Jin-Feng; Zhu Zun-Lue; Yang Xiang-Dong

    2005-01-01

    Total (elastic plus inelastic) cross sections (TCSs) for the scattering of positrons by molecules O2, H2O and CH4 in the energy range from 30 to 3000eV are calculated using the additivity rule model at Hartree-Fock level. A complex optical model potential modified by incorporating the concept of bonded atom which takes into considerationthe overlapping effect of electron clouds between two atoms in a molecule is firstly employed for the TCS calculation of positron-molecule scattering. TCSs are quantitatively compared with those obtained in experiments and other theorieswherever available, and good agreement is obtained in the energy range from 30 to 3000eV. It is shown that the additivity rule model together with the modified complex optical model potential is completely suitable for the TCS calculations of the positron-molecule scattering.

  11. The all-particle spectrum of primary cosmic rays in the wide energy range from 10^14 eV to 10^17 eV observed with the Tibet-III air-shower array

    CERN Document Server

    Amenomori, M

    2008-01-01

    We present an updated all-particle energy spectrum of primary cosmic rays in a wide range from 10^14 eV to 10^17 eV using 5.5 times 10^7 events collected in the period from 2000 November through 2004 October by the Tibet-III air-shower array located at 4300 m above sea level (atmospheric depth of 606 g/cm^2). The size spectrum exhibits a sharp knee at a corresponding primary energy around 4 PeV. This work uses increased statistics and new simulation calculations for the analysis. We performed extensive Monte Carlo calculations and discuss the model dependences involved in the final result assuming interaction models of QGSJET01c and SIBYLL2.1 and primary composition models of heavy dominant (HD) and proton dominant (PD) ones. Pure proton and pure iron primary models are also examined as extreme cases. The detector simulation was also made to improve the accuracy of determining the size of the air showers and the energy of the primary particle. We confirmed that the all-particle energy spectra obtained under v...

  12. A Correlation Potential Method for Electron Scattering Total Cross Section Calculations on Several Diatomic and Polyatomic Molecules over Energy Range 10 ~ 5000 eV

    Institute of Scientific and Technical Information of China (English)

    LIU Yu-Fang; SHI De-Heng; SUN Jin-Feng; ZHU Zun-Lue; YANG Xiang-Dong

    2005-01-01

    A complex optical model potential correlated by the concept of bonded atom, which considers the overlapping effect of electron clouds between two atoms in a molecule, is firstly employed to calculate the total cross sections for electron scattering on several molecules (NH3, H2O, CH4, CO, N2, O2, and C2H4) over the energy range 10 ~ 5000 eV using the additivity rule model at Hartree-Fock level. The difference between the bonded atom and the free one in states is that the overlapping effect of electron clouds of bonded atoms in a molecule is considered. The quantitative total cross sections are compared with the experimental data and with the other calculations wherever available and good agreement is obtained over the energy range 10 ~ 5000 eV. It is shown that the correlated calculations are much closer to the available experimental data than the uncorrelated ones at lower energies, especially below 500 eV. Therefore,considering the overlapping effect of electron clouds in the complex optical model potential could be helpful for the better accuracy of the total cross section calculations of electron scattering from molecules.

  13. Fermi Bubble as a Source of Cosmic Rays in the Energy Range > 10E15 eV

    CERN Document Server

    Cheng, K S; Dogiel, V A; Ko, C M; Ip, W H; Wang, Y

    2011-01-01

    Fermi-LAT has recently discovered two giant gamma-ray-bubbles which extend in the North and South of the Galactic center with diameter and height of the order of $H\\sim 10$ kpc. We suggest that periodic star capture processes by the galactic supermassive black hole, Sgr A$^*$, with a capture rate $\\tau_{cap}^{-1}\\sim 3\\times 10^{-5}$ yr$^{-1}$ and energy release $W\\sim 3\\times 10^{52}$ erg per capture can produce hot plasma injecting into the Galactic halo at a wind velocity $u\\sim 10^8$ cm/s. The periodic injection of hot plasma can produce a series of shocks. Energetic protons in the Bubble are re-accelerated when they interact with these shocks. We show that for energy larger than $E > 10^{15}$ eV, acceleration process can be better described by the stochastic second order Fermi acceleration. We propose that hadronic CRs within the "knee" of the observed CR spectrum are produced by Galactic supernova remnants (SNRs) distributed in the Galactic disk. Re-acceleration of these particles in the Fermi Bubble pr...

  14. VUV photoionization of acetamide studied by electron/ion coincidence spectroscopy in the 8-24 eV photon energy range

    KAUST Repository

    Schwell, Martin

    2012-01-01

    A VUV photoionization study of acetamide was carried out over the 8-24 eV photon energy range using synchrotron radiation and photoelectron/photoion coincidence (PEPICO) spectroscopy. Threshold photoelectron photoion coincidence (TPEPICO) measurements were also made. Photoion yield curves and branching ratios were measured for the parent ion and six fragment ions. The adiabatic ionization energy of acetamide was determined as I.E. (1 2A′) = (9.71 ± 0.02) eV, in agreement with an earlier reported photoionization mass spectrometry (PIMS) value. The adiabatic energy of the first excited state of the ion, 1 2A″, was determined to be ≈10.1 eV. Assignments of the fragment ions and the pathways of their formation by dissociative photoionization were made. The neutral species lost in the principal dissociative photoionization processes are CH 3, NH 2, NH 3, CO, HCCO and NH 2CO. Heats of formation are derived for all ions detected and are compared with literature values. Some astrophysical implications of these results are discussed. © 2011 Elsevier B.V. All rights reserved.

  15. Spectrum and mass composition of cosmic rays in the energy range 1015–1018 eV derived from the Yakutsk array data

    Directory of Open Access Journals (Sweden)

    Sabourov A.

    2013-06-01

    Full Text Available A spectrum of cosmic rays within energy range 1015 − 3 × 1017 eV was derived from the data of the small Cherenkov setup, which is a part of the Yakutsk complex EAS array. In this, work a new series of observation is covered. These observations lasted from 2000 till 2010 and resulted in increased number of registered events within interval 1016–1018 eV, which in turn made it possible to reproduce cosmic ray spectrum in this energy domain with better precision. A sign of a thin structure is observed in the shape of the spectrum. It could be related to the escape of heavy nuclei from our Galaxy. Cosmic ray mass composition was obtained for the energy region 1016–1018 eV. A joint analysis of spectrum and mass composition of cosmic rays was performed. Obtained results are considered in the context of theoretical computations that were performed with the use of hypothesis of galactic and meta-galactic origin of cosmic rays.

  16. Dissociative double-photoionization of butadiene in the 25-45 eV energy range using 3-D multi-coincidence ion momentum imaging spectrometry.

    Science.gov (United States)

    Oghbaie, Shabnam; Gisselbrecht, Mathieu; Laksman, Joakim; Månsson, Erik P; Sankari, Anna; Sorensen, Stacey L

    2015-09-21

    Dissociative double-photoionization of butadiene in the 25-45 eV energy range has been studied with tunable synchrotron radiation using full three-dimensional ion momentum imaging. Using ab initio calculations, the electronic states of the molecular dication below 33 eV are identified. The results of the measurement and calculation show that double ionization from π orbitals selectively triggers twisting about the terminal or central C-C bonds. We show that this conformational rearrangement depends upon the dication electronic state, which effectively acts as a gateway for the dissociation reaction pathway. For photon energies above 33 eV, three-body dissociation channels where neutral H-atom evaporation precedes C-C charge-separation in the dication species appear in the correlation map. The fragment angular distributions support a model where the dication species is initially aligned with the molecular backbone parallel to the polarization vector of the light, indicating a high probability for double-ionization to the "gateway states" for molecules with this orientation. PMID:26395707

  17. Facilities and techniques for x-ray diagnostic calibration in the 100-eV to 100-keV energy range

    International Nuclear Information System (INIS)

    The Lawrence Livermore National Laboratory (LLNL) has been a pioneer in the field of x-ray diagnostic calibration for more than 20 years. We have built steady state x-ray sources capable of supplying fluorescent lines of high spectral purity in the 100-eV to 100-keV energy range, and these sources have been used in the calibration of x-ray detectors, mirrors, crystals, filters, and film. This paper discusses our calibration philosophy and techniques, and describes some of our x-ray sources. Examples of actual calibration data are presented as well

  18. R-matrix analysis of the 241Pu neutron cross sections in the energy range thermal to 300 eV

    International Nuclear Information System (INIS)

    The report is a description of the analysis of the 241Pu neutron cross sections in the resolved resonance region at Oak Ridge National Laboratory (ORNL) using the multilevel-multichannel Reich-Moore code SAMMY. The resonance parameters were obtained in the energy range 0 to 300 eV. The table of the resonance parameters is given with some statistical properties of the parameters. Tabulated and graphical comparison between the experimental data and the calculated cross sections are given. The results are available in ENDF/B-V format and will be proposed for the evaluated data library JEF2 and ENDF/B-VI. 28 refs., 15 figs., 16 tabs

  19. 7 CFR 12.30 - NRCS responsibilities regarding wetlands.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 1 2010-01-01 2010-01-01 false NRCS responsibilities regarding wetlands. 12.30 Section 12.30 Agriculture Office of the Secretary of Agriculture HIGHLY ERODIBLE LAND AND WETLAND CONSERVATION Wetland Conservation § 12.30 NRCS responsibilities regarding wetlands. (a) Technical...

  20. A proposed search for dark-matter axions in the 0. 6--16. mu. eV range

    Energy Technology Data Exchange (ETDEWEB)

    Hagmann, C. (California Univ., Berkeley, CA (United States). Dept. of Physics); Moltz, D.M. (Lawrence Berkeley Lab., CA (United States)); Turner, M.S. (Chicago Univ., IL (United States). Dept. of Physics and Astronomy Fermi National Accelerator Lab., Batavia, IL (United States)); Sikivie, P.; Sullivan, N.S.; Tanner, D.B. (Florida Univ., Gainesville, FL (United States). Dept. of Physics); Bluele, A.I

    1991-11-01

    A proposed experiment is described to search for dark-matter axions in the mass range 0.6--16 {mu}eV. The method is based on the Primakoff conversion of axions into monochromatic microwave photons inside a tunable microwave cavity in a large volume high field magnet. This proposal capitalized on the availability of two Axicell magnets from the MFTF-B fusion machine at LLNL. Assuming a local dark-matter density in axions of {rho}{sub a}= 0.3 GeV/cm{sup 3}, the axion would be found or ruled out at the 97% c.1. in the above mass range in 48 months.

  1. A proposed search for dark-matter axions in the 0. 6--16. mu. eV range

    Energy Technology Data Exchange (ETDEWEB)

    van Bibber, K. (Lawrence Livermore National Lab., CA (USA)); Sikivie, P.; Sullivan, N.S.; Tanner, D.B. (Florida Univ., Gainesville, FL (USA). Dept. of Physics); Turner, M.S. (Chicago Univ., IL (USA). Dept. of Physics and Astronomy Fermi National Accelerator Lab., Batavia, IL (USA)); Moltz, D.M. (Lawrence Berkeley Lab., CA (USA))

    1991-03-01

    A proposed experiment is described to search for dark-matter axions in the mass range 0.6--16 {mu}eV. The method is based on the Primakoff conversion of axions into monochromatic microwave photons inside a tunable microwave cavity in a large volume high field magnet, as described by Sikivie. This proposal capitalizes on the availability of two Axicell magnets from the decommissioned MFTF-B fusion machine at LLNL. Assuming a local dark-matter density in axions of {rho} = 0.3 GeV/cm{sup 3}, the axion would be found or ruled out at the 97% c.l. in the above mass range in 48 months. 13 refs., 6 figs., 2 tabs.

  2. The energy-spectrum of light primaries in the range from 10^{16.6} to 10^{18.2} eV

    CERN Document Server

    Schoo, S; Arteaga-Velazquez, J C; Bekk, K; Bertaina, M; Bluemer, J; Bozdog, H; Brancus, I M; Cantoni, E; Chiavassa, A; Cossavella, F; Curcio, C; Daumiller, K; de Souza, V; Di Pierro, F; Doll, P; Engel, R; Engler, J; Fuchs, B; Fuhrmann, D; Gils, H J; Glasstetter, R; Grupen, C; Haungs, A; Heck, D; Hoerandel, J R; Huber, D; Huege, T; Kampert, K -H; Kang, D; Klages, H O; Link, K; Luczak, P; Ludwig, M; Mathes, H J; Mayer, H J; Melissas, M; Milke, J; Mitrica, B; Morello, C; Oehlschlaeger, J; Ostapchenko, S; Palmieri, N; Petcu, M; Pierog, T; Rebel, H; Roth, M; Schieler, H; Schroeder, F G; Sima, O; Toma, G; Trinchero, G C; Ulrich, H; Weindl, A; Wochele, D; Wochele, J

    2013-01-01

    Data of the Grande extension of the KASCADE experiment allows us to study extensive air showers induced by primary cosmic rays with energies above 10^{16} eV. The energy of an event is estimated in terms of the number of charged particles (Nch ) and the number of muons (N{\\mu} ) measured at an altitude of 110 m a.s.l. While a combination of the two numbers is used for the energy, the ratio defines the primary mass (group). The spectrum of the combined light and medium mass components, recently measured with KASCADE-Grande, was found to be compatible with both a single power-law and a broken power-law in the energy range between 10^{16.3} and 10^{18} eV. In this contribution we will present the investigation of possible structures in the spectrum of light primaries with increased statistics both from a larger data set including more recent measurements and by using a larger fiducial area than in the previous study. With the better statistical accuracy and with optimized selection criteria for enhancing light p...

  3. Differential cross sections of elastic electron scattering from CH4, CF4 and SF6 in the energy range 100-700eV

    Institute of Scientific and Technical Information of China (English)

    Ma Er-Jun; Ma Yu-Gang; Cai Xiang-Zhou; Fang De-Qing; Shen Wen-Qing; Tian Wen-Dong

    2007-01-01

    We investigate the differential cross sections (DCS) of elastic electron scattering from CH4, CF4 and SF6 at six impact energies in a range of 100-700eV by employing the independent atom model (IAM) together with the relativistic partial waves. The atom is present in an optical potential which is complex, spherically symmetric, and energy dependent. The optical potential of the atom is the sum of the direct static, dynamic polarization, local exchange and modified absorption potentials. The results obtained by using a modified absorption potential show significant improvements on the unmodified absorption potential results. The present results are generally in good agreement with experimental data available. In addition, the present results indicate that the structure of molecule manifests the observable effects on electron-molecule scattering.

  4. Luminescence excitation characteristics of Ca-, Na- and K-aluminosilicates (feldspars), in the stimulation range 20-500 eV: optical detection of XAS

    CERN Document Server

    Poolton, N R J; Quinn, F M; Pantos, E; Andersen, C E; Bøtter-Jensen, L; Johnsen, O; Murray, A S

    2003-01-01

    We demonstrate that the visible/UV luminescence from common feldspar crystals (NaAlSi sub 3 O sub 8 , KAlSi sub 3 O sub 8 and CaAl sub 2 Si sub 2 O sub 8) can be used to detect detailed L-edge and associated near-edge absorption structure of the main constituent atoms (Ca, K, Na, Al, Si), when exciting in the energy range 20-500 eV. Comparisons of the spectral features are drawn with similar measurements made on the associated materials SiO sub 2 , Al sub 2 O sub 3 and CaCO sub 3. The potential for using optically detected x-ray absorption spectroscopy as a method for identifying the luminescent components of mixed mineral samples is considered.

  5. Interactions of protons with furan molecules studied by collision-induced emission spectroscopy at the incident energy range of 50-1000 eV

    Science.gov (United States)

    Wasowicz, Tomasz J.; Pranszke, Boguslaw

    2016-08-01

    Investigations of the ion-molecule reactions provide insight into many fields ranging from the stellar wind interaction with interstellar media, up to medicine and industrial applications. Besides the applications, the understanding of these processes is itself a problem of fundamental importance. Thus, interactions of protons with the gas-phase furan molecules have been investigated for the first time in the energy range of 50-1000 eV exploiting collision-induced emission spectroscopy. Recorded spectra reveal emission of the atomic H β to H θ lines of the hydrogen Balmer series and the molecular bands of vibrationally and rotationally excited diatomic CH fragments created in the A2 Δ and B2Σ- electronic states. The measurements of the emission yields of the excited fragments by recording their intensities at different projectile energies have been performed. The highest yields have been observed for production of hydrogen atoms which intensities rapidly decreased with increasing principal quantum number n . From the H ( n = 4-7) intensity ratios depopulation factors of hydrogen excited states have been determined at each impact energy and possible collisional mechanisms leading to enhanced production of the hydrogen atoms have been suggested. We compare and discuss our results with improved data set of proton collisions with tetrahydrofuran (THF) molecules, the hydrogenated derivatives of furan.

  6. Fragmentation of tetrahydrofuran molecules by H(+), C(+), and O(+) collisions at the incident energy range of 25-1000 eV.

    Science.gov (United States)

    Wasowicz, Tomasz J; Pranszke, Bogusław

    2015-01-29

    We have studied fragmentation processes of the gas-phase tetrahydrofuran (THF) molecules in collisions with the H(+), C(+), and O(+) cations. The collision energies have been varied between 25 and 1000 eV and thus covered a velocity range from 10 to 440 km/s. The following excited neutral fragments of THF have been observed: the atomic hydrogen H(n), n = 4-9, carbon atoms in the 2p3s (1)P1, 2p4p (1)D2, and 2p4p (3)P states and vibrationally and rotationally excited diatomic CH fragments in the A(2)Δ and B(2)Σ(-) states. Fragmentation yields of these excited fragments have been measured as functions of the projectile energy (velocity). Our results show that the fragmentation mechanism depends on the projectile cations and is dominated by electron transfer from tetrahydrofuran molecules to cations. It has been additionally hypothesized that in the C(+)+THF collisions a [C-C4H8O](+) complex is formed prior to dissociation. The possible reaction channels involved in fragmentation of THF under the H(+), C(+), and O(+) cations impact are also discussed. PMID:25565161

  7. Primary proton and helium spectra at energy range from 50 TeV to 1015 eV observed with the new Tibet AS core detector array

    Directory of Open Access Journals (Sweden)

    Huang Jing

    2013-06-01

    Full Text Available A new EAS hybrid experiment has been designed by constructing a YAC (Yangbajing Air shower Core detector array inside the existing Tibet-III air shower array. The first step of YAC, called “YAC-I” has been successfully carried out in 2009–2010 together with Tibet-III air-shower array. YAC-II has also been operated from 2011. Preliminary results of YAC-I and performance of YAC-II are presented in this paper. The primary proton and helium spectra at energy range from50 TeV to 1015 eV derived from YAC-I data based on QGSJET2 and SIBYLL2.1 are reported. The obtained P+He spectrum is smoothly connected with directobservation data below 100 TeV and also with our previously reported results at higher energies within statistical error s. Based on these results and the sharp kneeof all-particle energy spectrum observed by our experiment, the possible origin of the sharp knee is discussed. See the published papers.

  8. Electron stopping power and inelastic mean free path in amino acids and protein over the energy range of 20-20,000 eV.

    Science.gov (United States)

    Tan, Zhenyu; Xia, Yueyuan; Zhao, Mingwen; Liu, Xiangdong

    2006-07-01

    Systematic calculations of stopping power (SPs) and inelastic mean free path (IMFP) values for 20-20,000 eV electrons in a group of 15 amino acids and a simple protein have been performed. The calculations are based on the dielectric response model and take into account the exchange effect between the incident electron and target electrons. The optical energy-loss functions for the 15 investigated amino acids and the protein are evaluated by using an empirical approach, because of the lack of experimental optical data. For all the considered materials, the calculated mean ionization potentials are in good agreement with those given by Bragg's rule, and the evaluated SP values at 20 keV converge well to the Bethe-Bloch predictions. The data shown represent the first results of SP and IMFP, for these 15 amino acids and the protein in the energy range below 20 keV, and might be useful for studies of various radiation effects in these materials. In addition, the average energy deposited by inelastic scattering of the electrons on this group of 15 amino acids, on the protein, on Formvar and on DNA, respectively, has been estimated for energies below 20 keV. The dependences of the average energy deposition on the electron energy are given. These results are important for any detailed studies of radiation-induced inactivation of proteins and the DNA. PMID:16733724

  9. Calculations of electron stopping powers for 41 elemental solids over the 50 eV to 30 keV range with the full Penn algorithm

    International Nuclear Information System (INIS)

    We present mass collision electron stopping powers (SPs) for 41 elemental solids (Li, Be, graphite, diamond, glassy C, Na, Mg, Al, Si, K, Sc, Ti, V, Cr, Fe, Co, Ni, Cu, Ge, Y, Nb, Mo, Ru, Rh, Pd, Ag, In, Sn, Cs, Gd, Tb, Dy, Hf, Ta, W, Re, Os, Ir, Pt, Au, and Bi) that were calculated from experimental energy-loss-function data with the full Penn algorithm for electron energies between 50 eV and 30 keV. Improved sets of energy-loss functions were used for 19 solids. Comparisons were made of these SPs with SPs calculated with the single-pole approximation, previous SP calculations, and experimental SPs. Generally satisfactory agreement was found with SPs from the single-pole approximation for energies above 100 eV, with other calculated SPs, and with measured SPs.

  10. Diffraction efficiencies of holographic laminar and blazed types gratings for use in a flat-field spectrograph in the 50-200 eV range for transmission electron microscopes

    Science.gov (United States)

    Imazono, T.; Koike, M.; Kawachi, T.; Koeda, M.; Nagano, T.; Sasai, H.; Oue, Y.; Yonezawa, Z.; Kuramoto, S.; Sano, K.

    2011-09-01

    A versatile soft x-ray flat-field grating spectrograph to be installed to a conventional transmission electron microscope has been developed. A holographic spherical grating of a 1200-lines/mm effective groove density which places emphasis on the low energy region of 50-200 eV is designed by an aspheric wavefront recording system. Laminar and blazed types master (LM and BM) gratings and their respective replica (LR and BR) gratings are fabricated by holographic exposure and ion-beam etching methods. Absolute diffraction efficiencies in the 50-300 eV range at the angle of incidence of 86.0 degrees were measured using a synchrotron radiation. The first order diffraction efficiencies are 6.1-7.5% (or 12%) for LM (or BM) and 7.4-9.6% (or 13%) for LR (or BR) gratings at near 55 eV, and over 5% (or 8%) in the 50-200 eV range for LM and LR (or BM and BR) gratings. The replica gratings show the comparable first-order diffraction efficiencies with their respective laminar and blazed types of master gratings.

  11. VUV photophysics and dissociative photoionization of pyrimidine, purine, imidazole and benzimidazole in the 7-18 eV photon energy range

    Energy Technology Data Exchange (ETDEWEB)

    Schwell, Martin [Laboratoire Interuniversitaire des Systemes Atmospheriques (LISA), CNRS-UMR 7583, Universite Paris 7 and 12, 61 Avenue du General de Gaulle, 94010 Creteil (France)], E-mail: schwell@lisa.univ-paris12.fr; Jochims, Hans-Werner; Baumgaertel, Helmut [Institut fuer Physikalische und Theoretische Chemie der Freien Universitaet Berlin, Takustr. 3, Berlin 14195 (Germany); Leach, Sydney [Laboratoire d' Etude du Rayonnement et de la Matiere en Astrophysique (LERMA), CNRS-UMR 8112, Observatoire de Paris-Meudon, 5 Place Jules-Janssen, 92195 Meudon (France)], E-mail: Sydney.Leach@obspm.fr

    2008-11-03

    Photoionization mass spectrometry is used to study ionization processes and fragmentation pathways of four prebiotic species, pyrimidine, purine, imidazole and benzimidazole, in the 7-18 eV photon energy region, with synchrotron radiation as excitation source. These molecules are possible precursors of the nucleic acid bases that occur in DNA and RNA. Ionization energies and ion appearance energies are reported. They are compared with electron impact and other studies and are discussed in terms of the electronic and nuclear structures of these species and their cations. The ion appearance energies, in conjunction with thermochemical data, were used to propose dissociative photoionization pathways, principally involving loss of HCN molecules in each of the four species. Astrophysical implications of the results concern the prospects for observation and survival of these molecules in the interstellar medium, in comets and in meteorites. Suggestions are made concerning suitable sites for radioastronomical searches for these purines and pyrimidines.

  12. R-MATRIX RESONANCE ANALYSIS AND STATISTICAL PROPERTIES OF THE RESONANCE PARAMETERS OF 233U IN THE NEUTRON ENERGY RANGE FROM THERMAL TO 600 eV

    Energy Technology Data Exchange (ETDEWEB)

    Leal, L.C.

    2001-02-27

    The R-matrix resonance analysis of experimental neutron transmission and cross sections of {sup 233}U, with the Reich-Moore Bayesian code SAMMY, was extended up to the neutron energy of 600 eV by taking advantage of new high resolution neutron transmission and fission cross section measurements performed at the Oak Ridge Electron Linear Accelerator (ORELA). The experimental data base is described. In addition to the microscopic data (time-of-flight measurements of transmission and cross sections), some experimental and evaluated integral quantities were included in the data base. Tabulated and graphical comparisons between the experimental data and the SAMMY calculated cross sections are given. The ability of the calculated cross sections to reproduce the effective multiplication factors k{sub eff} for various thermal, intermediate, and fast systems was tested. The statistical properties of the resonance parameters were examined and recommended values of the average s-wave resonance parameters are given.

  13. Broadband multilayer mirror and diffractive optics for attosecond pulse shaping in the 280-500 eV photon energy range

    Directory of Open Access Journals (Sweden)

    Schmidt J.

    2013-03-01

    Full Text Available Chirped broadband multilayer mirrors are key components to shape attosecond pulses in the XUV range. Compressing high harmonic pulses to their Fourier limit is the major goal for attosecond physics utilizing short pulse pump-probe experiments. Here, we report about the first implementation of multilayers and diffractive optics fulfilling these requirements in the “water-window” spectral range.

  14. Electron-impact rotationally elastic total cross sections for H{sub 2}CO and HCOOH over a wide range of incident energy (0.01-2000 eV)

    Energy Technology Data Exchange (ETDEWEB)

    Vinodkumar, Minaxi [V P and R P T P Science College, Vallabh Vidyanagar 388 120, Gujarat (India); Bhutadia, Harshad [Government Engineering College, Patan 384265, Gujarat (India); Antony, Bobby [Department of Applied Physics, Indian School of Mines, Dhanbad JH-826004 (India); Mason, Nigel [Department of Physics and Astronomy, Open University, Milton Keynes MK7 6AA (United Kingdom)

    2011-11-15

    This paper reports computational results of the total cross sections for electron impact on H{sub 2}CO and HCOOH over a wide range of electron impact energies from 0.01 eV to 2 keV. The total cross section is presented as sum of the elastic and electronic excitation cross sections for incident energies. The calculation uses two different methodologies, below the ionization threshold of the target the cross section is calculated using the UK molecular R-matrix code through the Quantemol-N software package while cross sections at higher energies are evaluated using the spherical complex optical potential formalism. The two methods are found to be consistent at the transition energy ({approx}15 eV). The present results are, in general, found to be in good agreement with previous experimental and theoretical results (wherever available) and, thus, the present results can serve as a benchmark for the cross section over a wide range of energy.

  15. Enumeration Verification System (EVS)

    Data.gov (United States)

    Social Security Administration — EVS is a batch application that processes for federal, state, local and foreign government agencies, private companies and internal SSA customers and systems. Each...

  16. Electron stopping power and mean free path in organic compounds over the energy range of 20-10,000 eV

    Science.gov (United States)

    Tan, Zhenyu; Xia, Yueyuan; Zhao, Mingwen; Liu, Xiangdong; Li, Feng; Huang, Boda; Ji, Yanju

    2004-07-01

    An empirical method to obtain optical energy loss functions is presented for a large number of organic compounds, for which optical data are not available, on the basis of structure feature analysis of the existed optical energy loss functions for certain organic compounds. The optical energy loss functions obtained by using this method are in good agreement with the experimental data. Based on the Penn's statistical model, a set of systematic expressions have been given for the calculation of the stopping powers and mean free paths of electrons penetrating into the organic compounds in the energy range of E⩽10 keV. Detailed comparison of the calculated data with other theoretical results is presented. The stopping powers and mean free paths for a group of important polymers, without available optical data, have been calculated. In the calculations, three different cases have been considered, i.e. exchange correction not being considered, Ashley exchange correction being involved, and Born-Ochkur exchange correction being included. The results indicate that for these compounds the calculated stopping powers agree well with those obtained by using Bethe-Bloch theory at high-energy limit E=10 keV, as expected for a stopping power theory that should be converged to Bethe-Bloch theory at high energies.

  17. The study in the primary energy range 10^{16} - 10^{17} eV with the Muon Tracking Detector in the KASCADE-Grande experiment

    CERN Document Server

    Łuczak, P; Arteaga-Velázquez, J C; Bekk, K; Bertaina, M; Blümer, J; Bozdog, H; Brancus, I M; Cantoni, E; Chiavassa, A; Cossavella, F; Curcio, C; Daumiller, K; de Souza, V; Di Pierro, F; Doll, P; Engel, R; Engler, J; Fuchs, B; Fuhrmann, D; Gils, H J; Glasstetter, R; Grupen, C; Haungs, A; Heck, D; Hörandel, J R; Huber, D; Huege, T; Kampert, K -H; Kang, D; Klages, H O; Link, K; Ludwig, M; Mathes, H J; Mayer, H J; Melissas, M; Milke, J; Mitrica, B; Morello, C; Oehlschläger, J; Ostapchenko, S; Palmieri, N; Petcu, M; Pierog, T; Rebel, H; Roth, M; Schieler, H; Schoo, S; Schröder, F G; Sima, O; Toma, G; Trinchero, G C; Ulrich, H; Weindl, A; Wochele, J; Zabierowski, J

    2013-01-01

    The KASCADE-Grande Muon Tracking Detector enables with high accuracy the measurement of directions of EAS muons with energy above 0.8 GeV and up to 700 m distance from the shower centre. Reconstructed muon tracks are used to investigate muon pseudorapidity (eta) distributions. These distributions are nearly identical to the pseudorapidity distributions of their parent mesons produced in hadronic interactions. Comparison of the eta distributions from measured and simulated showers can be used to test the quality of the high energy hadronic interaction models. In this context a comparison of the QGSJet-II-2 and QGSJet-II-4 model will be shown. The pseudorapidity distributions reflect the longitudinal development of EAS and, as such, are sensitive to the mass of the cosmic rays primary particles. With various parameters of the eta distribution, obtained from the MTD data, it is possible to calculate the mean logarithmic mass of CRs. The results of the analysis in the primary energy range 10^{16} eV - 10^{17} eV...

  18. Optical and Magneto-Optical Properties of Gd22Fe78 Thin Films in the Photon Energy Range From 1.5 to 5.5 eV

    Directory of Open Access Journals (Sweden)

    Eva Jesenská

    2016-01-01

    Full Text Available Optical and magneto-optical properties of amorphous Gd22Fe78 (GdFe thin films prepared by direct current (DC sputtering on thermally oxidized substrates were characterized by the combination of spectroscopic ellipsometry and magneto-optical spectroscopy in the photon energy range from 1.5 to 5.5 eV. Thin SiNx and Ru coatings were used to prevent the GdFe surface oxidation and contamination. Using advanced theoretical models spectral dependence of the complete permittivity tensor and spectral dependence of the absorption coefficient were deduced from experimental data. No significant changes in the optical properties upon different coatings were observed, indicating reliability of used analysis.

  19. How Do The EV Project Participants Feel About Their EVS?

    Energy Technology Data Exchange (ETDEWEB)

    Francfort, James E. [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2015-02-01

    The EV Project is an infrastructure study that enrolled over 8,000 residential participants. These participants purchased or leased a Nissan Leaf battery electric vehicle (BEV) or Chevrolet Volt extended range electric vehicle (EREV) and were among the first to explore this new electric drive technology. Collectively, BEV, EREV, and plug-in hybrid electric vehicles (PHEVs) are called plug-in electric vehicles (PEVs). The EV Project participants were very cooperative and enthusiastic about their participation in the project and very supportive in providing feedback and information. The information and attitudes of these participants concerning their experience with their PEVs were solicited using a survey in June 2013. At that time, some had up to 3 years of experience with their PEVs.

  20. Photoionisation of Cl+ from the 3s23p4 3P2, 1, 0 and the 3s23p4 1D2, 1S0 states in the energy range 19 - 28 eV

    Science.gov (United States)

    McLaughlin, Brendan M.

    2016-10-01

    Absolute photoionisation cross sections for the Cl+ ion in its ground and the metastable states; 3s23p4 3P2, 1, 0, and 3s23p4 1D2, 1S0, were measured recently at the Advanced Light Source (ALS) at Lawrence Berkeley National Laboratory using the merged beams photon-ion technique at an photon energy resolution of 15 meV in the energy range 19 - 28 eV. These measurements are compared with large-scale Dirac Coulomb R-matrix calculations in the same energy range. Photoionisation of this sulphur-like chlorine ion is characterized by multiple Rydberg series of autoionizing resonances superimposed on a direct photoionisation continuum. A wealth of resonance features observed in the experimental spectra are spectroscopically assigned and their resonance parameters tabulated and compared with the recent measurements. Metastable fractions in the parent ion beam are determined from the present study. Theoretical resonance energies and quantum defects of the prominent Rydberg series 3s23p3nd, identified in the spectra as 3p → nd transitions are compared with the available measurements made on this element. Weaker Rydberg series 3s23p3ns, identified as 3p → ns transitions and window resonances 3s3p4(4P)np features, due to 3s → np transitions are also found in the spectra.

  1. Modeling of Electric Vehicles (EVs) for EV Grid Integration Study

    DEFF Research Database (Denmark)

    Wu, Qiuwei; Nielsen, Arne Hejde; Østergaard, Jacob;

    2010-01-01

    In order to successfully integrate EVs into power systems, it is necessary to develop a detailed EV model considering both the EV users’ driving requirements and the battery charging and discharging characteristics. A generic EV model was proposed which takes into account charging and discharging...

  2. Suramin inhibits EV71 infection.

    Science.gov (United States)

    Wang, Yaxin; Qing, Jie; Sun, Yuna; Rao, Zihe

    2014-03-01

    Enterovirus-71 (EV71) is one of the major causative reagents for hand-foot-and-mouth disease. In particular, EV71 causes severe central nervous system infections and leads to numerous dead cases. Although several inactivated whole-virus vaccines have entered in clinical trials, no antiviral agent has been provided for clinical therapy. In the present work, we screened our compound library and identified that suramin, which has been clinically used to treat variable diseases, could inhibit EV71 proliferation with an IC50 value of 40 μM. We further revealed that suramin could block the attachment of EV71 to host cells to regulate the early stage of EV71 infection, as well as affected other steps of EV71 life cycle. Our results are helpful to understand the mechanism for EV71 life cycle and provide a potential for the usage of an approved drug, suramin, as the antiviral against EV71 infection.

  3. Valence and inner-valence shell dissociative photoionization of CO in the 26-33 eV range. II. Molecular-frame and recoil-frame photoelectron angular distributions

    DEFF Research Database (Denmark)

    Lebech, M.; Houver, J.C.; Raseev, G.;

    2012-01-01

    Experimental and theoretical results for molecular-frame photoemission are presented for inner-valence shell photoionization of the CO molecule induced by linearly and circularly polarized light. The experimental recoil frame photoelectron angular distributions (RFPADs) obtained from dissociative...... for the case of general elliptically polarized light, to obtain the RFPAD rather than the molecular frame photoelectron angular distribution (MFPAD), which would be obtained with the assumption of instantaneous dissociation. We have considered photoionization of CO for the photon energies of 26.0 eV, 29.5 e...

  4. Change of Primary Cosmic Radiation Nuclear Conposition in the Energy Range $10^{15} - 10^{17}$ eV as a Result of the Interaction with the Interstellar Cold Background of Light Particles

    CERN Document Server

    Barnaveli, T T; Khaldeeva, I V

    2003-01-01

    In this paper the updated arguments in favor of a simple model, explaining from the united positions all peculiarities of the Extensive Air Shower (EAS) hadron E_h(E_0) (and muon E_mu(E_0)) component energy fluxes dependence on the primary particle energy E_0 in the primary energy region 10^{15} - 10^{17} eV are represented. These peculiarities have shapes of consequent distinct deeps of a widths dE_h/E_h of the order of 0.2 and of relative amplitudes dL/L of the order of {0.1 - 1.0}, and are difficult to be explained via known astrophysical mechanisms of particle generation and acceleration. In the basis of the model lies the destruction of the Primary Cosmic Radiation (PCR) nuclei on some monochromatic background of interstellar space, consisting of the light particles of the mass in the area of 36 eV (maybe the component of a dark matter). The destruction thresholds of PCR different nuclear components correspond to the peculiarities of E_h(E_0). In this work the results of the recent treatment of large sta...

  5. Study of some properties of 's' neutron resonance parameters for target nuclei I = 1/2 and I = 3/2 in function of spin value J = I + 1/2 in the energy range 1 {yields} 5000 eV; Etude de quelques proprietes des parametres de resonances des neutrons ''s'' pour des noyaux cibles I = 1/2 et I = 3/2 en fonction de la valeur du spin J = I + 1/2 dans le domaine d'energie 1 eV {yields} 5000 eV

    Energy Technology Data Exchange (ETDEWEB)

    Julien, J. [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1967-05-15

    Different kinds of experiments and analysis methods allowing to achieve neutron resonances parameters in the low energy range (1 eV {yields} 5000 eV) are described. A great deal of effort to improve experimental conditions and data processing in order to know the spin value J = I {+-} 1/2 has been spent. The time of flight method was used. A few target nuclei I = 3/2 and 1 = 1/2 have been studied. For I = 3/2 (Ga, As, 3r, Au) we find S{sub o} J = 2 {approx_equal} 2 S{sub o} J = 1 and S{sub o} J = 1 {approx_equal} S{sub o} J = 0 for I = 1/2 (Tm, Pt) but {sup 77}Se. Fluctuations of the total radiative width {gamma}{sub {gamma}} depend on the spin value I = I {+-} 1/2 when E1 transition, are enhanced for one of the both spin states. The magnitude of these fluctuations can be explained of the strength of E1 transitions (E{sub {gamma}} {approx} 7 MeV) is supposed to be proportional to E{sup 5}{sub {gamma}} instead of E{sup 3}{sub {gamma}}. The distribution of levels spacings against spin value J are considered and are compared to theoretical predictions. (author) [French] On decrit les differentes methodes d'analyse permettant d'obtenir les parametres des resonances de neutron dans le domaine d'energie 1 eV {yields} 5000 eV. Un effort particulier a ete fait pour connaitre la valeur du spin J = I {+-} 1/2. Les types d'experience et les analyses des donnees, developpes et ameliores pour determiner J sont decrits. Les resultats obtenus ont permis l'etude de differentes proprietes en fonction du spin J. On trouve: S{sub o} J 2 {approx_equal} 2 S{sub o} J = 1 pour les noyaux I = 3/2 etudies (Ga, As, Br, Au) et S{sub o} J = 1 {approx_equal} S{sub o} J = 0 Pour le Tm et {sup 195}Pt de spin I = 1/2. On constate que les largeurs radiatives totales {gamma}{sub {gamma}} fluctuent si des transitions E1 aux premiers etats excites sont favorisees. Ces fluctuations peuvent etre expliquees si on suppose que les intensites de ces transitions sont

  6. EV-GHG Mobile Source

    Data.gov (United States)

    U.S. Environmental Protection Agency — The EV-GHG Mobile Source Data asset contains measured mobile source GHG emissions summary compliance information on light-duty vehicles, by model, for certification...

  7. DOE Field Operations Program EV and HEV Testing

    Energy Technology Data Exchange (ETDEWEB)

    Francfort, James Edward; Slezak, L. A.

    2001-10-01

    The United States Department of Energy’s (DOE) Field Operations Program tests advanced technology vehicles (ATVs) and disseminates the testing results to provide fleet managers and other potential ATV users with accurate and unbiased information on vehicle performance. The ATVs (including electric, hybrid, and other alternative fuel vehicles) are tested using one or more methods - Baseline Performance Testing (EVAmerica and Pomona Loop), Accelerated Reliability Testing, and Fleet Testing. The Program (http://ev.inel.gov/sop) and its nine industry testing partners have tested over 30 full-size electric vehicle (EV) models and they have accumulated over 4 million miles of EV testing experience since 1994. In conjunction with several original equipment manufacturers, the Program has developed testing procedures for the new classes of hybrid, urban, and neighborhood EVs. The testing of these vehicles started during 2001. The EVS 18 presentation will include (1) EV and hybrid electric vehicle (HEV) test results, (2) operating experience with and performance trends of various EV and HEV models, and (3) experience with operating hydrogen-fueled vehicles. Data presented for EVs will include vehicle efficiency (km/kWh), average distance driven per charge, and range testing results. The HEV data will include operating considerations, fuel use rates, and range testing results.

  8. Digitaliseerimise demopäev

    Index Scriptorium Estoniae

    1999-01-01

    8. XI tarbekunstimuuseumis, 10. XI rahvusraamatukogus digitaliseerimise demopäev koostöös OÜ Art Digitali, Eesti Kultuuriministeeriumi, Tarbekunstimuuseumi ja Eesti Rahvusraamatukoguga. OÜ Art Digital (asutasid 1998. a. Rein Tammik, Mauri Gross) skaneeris 1999. a. suvel Eesti Kunstimuuseumis 2400 graafilist lehte ja maali. Eesti digikeskuse loomisest, ülesannetest

  9. Kloostripäev Pirital

    Index Scriptorium Estoniae

    2003-01-01

    15. VIII Pirita kloostris konverents "Birgitiinide kodust Pirita asumiks". Esinevad Toomas Abiline, Jaan Tamm, Robert Nerman, Krista Kodres. Fuajees näitus Albin Strutzkini materjalidest Tallinna linnamuuseumis, Pirita postkaartide väljapanek Viktor Kuigi kogust. Eksponeeritud Tiina Veisseriku ikoonid tekstiilil, Anatoli Ljutjuki sari "Süütult solvatute kirik" kloostrivaremetes. Päev lõpeb rockoratooriumiga "Naerusuine vabadus"

  10. Inhibition of enterovirus 71 (EV-71 infections by a novel antiviral peptide derived from EV-71 capsid protein VP1.

    Directory of Open Access Journals (Sweden)

    Chee Wah Tan

    Full Text Available Enterovirus 71 (EV-71 is the main causative agent of hand, foot and mouth disease (HFMD. In recent years, EV-71 infections were reported to cause high fatalities and severe neurological complications in Asia. Currently, no effective antiviral or vaccine is available to treat or prevent EV-71 infection. In this study, we have discovered a synthetic peptide which could be developed as a potential antiviral for inhibition of EV-71. Ninety five synthetic peptides (15-mers overlapping the entire EV-71 capsid protein, VP1, were chemically synthesized and tested for antiviral properties against EV-71 in human Rhabdomyosarcoma (RD cells. One peptide, SP40, was found to significantly reduce cytopathic effects of all representative EV-71 strains from genotypes A, B and C tested, with IC(50 values ranging from 6-9.3 µM in RD cells. The in vitro inhibitory effect of SP40 exhibited a dose dependent concentration corresponding to a decrease in infectious viral particles, total viral RNA and the levels of VP1 protein. The antiviral activity of SP40 peptide was not restricted to a specific cell line as inhibition of EV-71 was observed in RD, HeLa, HT-29 and Vero cells. Besides inhibition of EV-71, it also had antiviral activities against CV-A16 and poliovirus type 1 in cell culture. Mechanism of action studies suggested that the SP40 peptide was not virucidal but was able to block viral attachment to the RD cells. Substitutions of arginine and lysine residues with alanine in the SP40 peptide at positions R3A, R4A, K5A and R13A were found to significantly decrease antiviral activities, implying the importance of positively charged amino acids for the antiviral activities. The data demonstrated the potential and feasibility of SP40 as a broad spectrum antiviral agent against EV-71.

  11. How Do The EV Project Participants Feel About Charging Their EV Away From Home?

    Energy Technology Data Exchange (ETDEWEB)

    Francfort, James E. [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2015-02-01

    The EV Project is an infrastructure study that enrolled over 8,000 residential participants. These participants purchased or leased a Nissan Leaf battery electric vehicle or Chevrolet Volt extended-range electric vehicle and were among the first to explore this new electric drive technology. Collectively, battery electric vehicles, extended-range electric vehicles, and plug-in hybrid electric vehicles are called PEVs. The EV Project participants were very cooperative and enthusiastic about their participation in the project and very supportive in providing feedback and information. The information and attitudes of these participants concerning their experience with their PEVs were solicited using a survey in June 2013. At that time, some had up to 3 years of experience with their PEVs.

  12. Study of some properties of 's' neutron resonance parameters for target nuclei I = 1/2 and I = 3/2 in function of spin value J = I + 1/2 in the energy range 1 → 5000 eV

    International Nuclear Information System (INIS)

    Different kinds of experiments and analysis methods allowing to achieve neutron resonances parameters in the low energy range (1 eV → 5000 eV) are described. A great deal of effort to improve experimental conditions and data processing in order to know the spin value J = I ± 1/2 has been spent. The time of flight method was used. A few target nuclei I = 3/2 and 1 = 1/2 have been studied. For I = 3/2 (Ga, As, 3r, Au) we find So J = 2 ≅ 2 So J = 1 and So J = 1 ≅ So J = 0 for I = 1/2 (Tm, Pt) but 77Se. Fluctuations of the total radiative width Γγ depend on the spin value I = I ± 1/2 when E1 transition, are enhanced for one of the both spin states. The magnitude of these fluctuations can be explained of the strength of E1 transitions (Eγ ∼ 7 MeV) is supposed to be proportional to E5γ instead of E3γ. The distribution of levels spacings against spin value J are considered and are compared to theoretical predictions. (author)

  13. Markets Share Models for EVs

    DEFF Research Database (Denmark)

    Jensen, Thomas Christian; Christensen, Linda

    A number of electric vehicles (EVs) matching ordinary conventional cars is on (or close to) the market and by now several stations and battery switch stations has been set up. Electrical vehi-cles are widely seen as an important tool for reducing CO2 emissions with a considerable reduc......-tion potential. The recent development has increased the knowledge of costs of stations and cars, but the knowledge of the market potential of EVs is still limited. In the traffic agreement of January 2009 electric vehicles were highlighted as part of the solution for future CO2 problems. Here, the target...... new cars to 95 g/km on average in 2020. The energy agreement from March 2012 states that the transport sec-tor is facing a radical change from fossil fuels to electricity and bio-mass in the long run. Here, the target for 2020 is 10% bio-fuels in 2020 and the tax exemption for EVs is prolonged...

  14. Absolute Integral Cross Sections for the State-selected Ion–Molecule Reaction N2+(X2Σg+ v+ = 0–2) + C2H2 in the Collision Energy Range of 0.03–10.00 eV

    Science.gov (United States)

    Xu, Yuntao; Xiong, Bo; Chung Chang, Yih; Ng, C. Y.

    2016-08-01

    Using the vacuum ultraviolet laser pulsed field ionization-photoion source, together with the double-quadrupole–double-octopole mass spectrometer developed in our laboratory, we have investigated the state-selected ion–molecule reaction {{{{N}}}2}+({X}2{{{{Σ }}}{{g}}}+; v + = 0–2, N+ = 0–9) + C2H2, achieving high internal-state selectivity and high kinetic energy resolution for reactant {{{{N}}}2}+ ions. The charge transfer (CT) and hydrogen-atom transfer (HT) channels, which lead to the respective formation of product {{{C}}}2{{{{H}}}2}+ and N2H+ ions, are observed. The vibrationally selected absolute integral cross sections for the CT [σ CT(v +)] and HT [[σ HT(v +)] channels obtained in the center-of-mass collision energy (E cm) range of 0.03–10.00 eV reveal opposite E cm dependences. The σ CT(v +) is found to increase as E cm is decreased, and is consistent with the long-range exothermic CT mechanism, whereas the E cm enhancement observed for the σ HT(v +) suggests effective coupling of kinetic energy to internal energy, enhancing the formation of N2H+. The σ HT(v +) curve exhibits a step at E cm = 0.70–1.00 eV, suggesting the involvement of the excited {{{C}}}2{{{{H}}}2}+({A}2{{{{Σ }}}{{g}}}+) state in the HT reaction. Contrary to the strong E cm dependences for σ CT(v +) and σ HT(v +), the effect of vibrational excitation of {{{{N}}}2}+ on both the CT and HT channels is marginal. The branching ratios and cross sections for the CT and HT channels determined in the present study are useful for modeling the atmospheric compositions of Saturn's largest moon, Titan. These cross sections and branching ratios are also valuable for benchmarking theoretical calculations on chemical dynamics of the titled reaction.

  15. Photoionisation of Cl$^+$ from the $3s^23p^4\\;^3P_{2,1,0}$ and the$3s^23p^4\\;^1D_2, ^1S_0$ states in the energy range 19 - 28 eV

    CERN Document Server

    McLaughlin, Brendan M

    2016-01-01

    Absolute photoionisation cross sections for the Cl$^+$ ion in its ground and the metastable states; $3s^2 3p^4\\; ^3P_{2,1,0}$, and $3s^2 3p^4\\; ^1D_2,\\; ^1S_0$, were measured recently at the Advanced Light Source ALS) at Lawrence Berkeley National Laboratory using the merged beams photon-ion technique at an photon energy resolution of 15 meV in the energy range 19 -- 28 eV. These measurements are compared with large-scale Dirac Coulomb {\\it R}-matrix calculations in the same energy range. Photoionisation of this sulphur-like chlorine ion is characterized by multiple Rydberg series of autoionizing resonances superimposed on a direct photoionisation continuum. A wealth of resonance features observed in the experimental spectra are spectroscopically assigned and their resonance parameters tabulated and compared with the recent measurements. Metastable fractions in the parent ion beam are determined from the present study. Theoretical resonance energies and quantum defects of the prominent Rydberg series $3s^2 3p...

  16. Serological detection and analysis of anti-VP1 responses against various enteroviruses (EV) (EV-A, EV-B and EV-C) in Chinese individuals.

    Science.gov (United States)

    Gao, Caixia; Ding, Yingying; Zhou, Peng; Feng, Jiaojiao; Qian, Baohua; Lin, Ziyu; Wang, Lili; Wang, Jinhong; Zhao, Chunyan; Li, Xiangyu; Cao, Mingmei; Peng, Heng; Rui, Bing; Pan, Wei

    2016-01-01

    The overall serological prevalence of EV infections based on ELISA remains unknown. In the present study, the antibody responses against VP1 of the EV-A species (enterovirus 71 (EV71), Coxsackievirus A16 (CA16), Coxsackievirus A5 (CA5) and Coxsackievirus A6 (CA6)), of the EV-B species (Coxsackievirus B3 (CB3)), and of the EV-C species (Poliovirus 1 (PV1)) were detected and analyzed by a NEIBM (novel evolved immunoglobulin-binding molecule)-based ELISA in Shanghai blood donors. The serological prevalence of anti-CB3 VP1 antibodies was demonstrated to show the highest level, with anti-PV1 VP1 antibodies at the second highest level, and anti-CA5, CA6, CA16 and EV71 VP1 antibodies at a comparatively low level. All reactions were significantly correlated at different levels, which were approximately proportional to their sequence similarities. Antibody responses against EV71 VP1 showed obvious differences with responses against other EV-A viruses. Obvious differences in antibody responses between August 2013 and May 2014 were revealed. These findings are the first to describe the detailed information of the serological prevalence of human antibody responses against the VP1 of EV-A, B and C viruses, and could be helpful for understanding of the ubiquity of EV infections and for identifying an effective approach for seroepidemiological surveillance based on ELISA. PMID:26917423

  17. Serological detection and analysis of anti-VP1 responses against various enteroviruses (EV) (EV-A, EV-B and EV-C) in Chinese individuals

    Science.gov (United States)

    Gao, Caixia; Ding, Yingying; Zhou, Peng; Feng, Jiaojiao; Qian, Baohua; Lin, Ziyu; Wang, Lili; Wang, Jinhong; Zhao, Chunyan; Li, Xiangyu; Cao, Mingmei; Peng, Heng; Rui, Bing; Pan, Wei

    2016-01-01

    The overall serological prevalence of EV infections based on ELISA remains unknown. In the present study, the antibody responses against VP1 of the EV-A species (enterovirus 71 (EV71), Coxsackievirus A16 (CA16), Coxsackievirus A5 (CA5) and Coxsackievirus A6 (CA6)), of the EV-B species (Coxsackievirus B3 (CB3)), and of the EV-C species (Poliovirus 1 (PV1)) were detected and analyzed by a NEIBM (novel evolved immunoglobulin-binding molecule)-based ELISA in Shanghai blood donors. The serological prevalence of anti-CB3 VP1 antibodies was demonstrated to show the highest level, with anti-PV1 VP1 antibodies at the second highest level, and anti-CA5, CA6, CA16 and EV71 VP1 antibodies at a comparatively low level. All reactions were significantly correlated at different levels, which were approximately proportional to their sequence similarities. Antibody responses against EV71 VP1 showed obvious differences with responses against other EV-A viruses. Obvious differences in antibody responses between August 2013 and May 2014 were revealed. These findings are the first to describe the detailed information of the serological prevalence of human antibody responses against the VP1 of EV-A, B and C viruses, and could be helpful for understanding of the ubiquity of EV infections and for identifying an effective approach for seroepidemiological surveillance based on ELISA. PMID:26917423

  18. Moby.Cockpit Project for EV seamless integration in the cooperative transport infrastructure

    OpenAIRE

    João C. Ferreira; Monteiro, Vítor Duarte Fernandes; Afonso, João L.

    2013-01-01

    Electric Vehicles (EV) are being introduced in the market, however the reduced energy storage capacity of their batteries and the lack of a high density charging infrastructure, limits their autonomy range. In order to overcome this limitation, we propose the development of a new solution for EV drivers that enables to travel longer distances. This is achieved by integrating some components of the cooperative transport infrastructure, as EV battery charging systems and public transports syste...

  19. Production of EV71 vaccine candidates.

    Science.gov (United States)

    Chong, Pele; Hsieh, Shih-Yang; Liu, Chia-Chyi; Chou, Ai-Hsiang; Chang, Jui-Yuan; Wu, Suh-Chin; Liu, Shih-Jen; Chow, Yen-Hung; Su, Ih-Jen; Klein, Michel

    2012-12-01

    Enterovirus 71 (EV71) is now recognized as an emerging neurotropic virus in Asia and with Coxsackie virus (CV) it is the other major causative agent of hand-foot-mouth diseases (HFMD). Effective medications and/or prophylactic vaccines against HFMD are urgently needed. From a scientific (the feasibility of bioprocess, immunological responses and potency in animal challenge model) and business development (cost of goods) points of view, we in this review address and discuss the pros and cons of different EV71 vaccine candidates that have been produced and evaluated in animal models. Epitope-based synthetic peptide vaccine candidates containing residues 211-225 of VP1 formulated with Freund's adjuvant (CFA/IFA) elicited low EV71 virus neutralizing antibody responses, but were protective in the suckling mouse challenge model. Among recombinant EV71 subunits (rVP1, rVP2 and rVP3) expressed in E. coli, purified and formulated with CFA/IFA, only VP1 elicited mouse antibody responses with measurable EV71-specific virus neutralization titers. Immunization of mice with either a DNA plasmid containing VP1 gene or VP1 expressed in Salmonella typhimurium also generated neutralizing antibody responses and protected animals against a live EV71 challenge. Recombinant EV71 virus-like particles (rVLP) produced from baculovirus formulated either with CFA/IFA or alum elicited good virus neutralization titers in both mice and non-human primates, and were found to be protective in the suckling mouse EV71 challenge model. Synthetic peptides or recombinant EV71 subunit vaccines (rVP1 and rVLP) formulated in alum were found to be poorly immunogenic in rabbits. Only formalin-inactivated (FI) EV71 virions formulated in alum elicited cross-neutralizing antibodies against different EV71 genotypes in mice, rabbits and non-human primates but induced weak neutralizing responses against CAV16. From a regulatory, economic and market acceptability standpoint, FI-EV71 virion vaccines are the most

  20. Sensitivity of an image plate system in the XUV (60 eV < E < 900 eV)

    CERN Document Server

    Failor, B H; Link, N G; Riordan, J C; Wilson, B C

    2012-01-01

    Phosphor imaging plates (IPs) have been calibrated and proven useful for quantitative x-ray imaging in the 1 to over 1000 keV energy range. In this paper we report on calibration measurements made at XUV energies in the 60 to 900 eV energy range using beamline 6.3.2 at the Advanced Light Source at Lawrence Berkeley National Laboratory. We measured a sensitivity of ~25 plus or minus 15 counts/pJ over the stated energy range which is compatible with the sensitivity of Si photodiodes that are used for time-resolved measurements. Our measurements at 900 eV are consistent with the measurements made by Meadowcroft et al. at ~1 keV.

  1. A novel finding for enterovirus virulence from the capsid protein VP1 of EV71 circulating in mainland China.

    Science.gov (United States)

    Liu, Yongjuan; Fu, Chong; Wu, Suying; Chen, Xiong; Shi, Yingying; Zhou, Bingfei; Zhang, Lianglu; Zhang, Fengfeng; Wang, Zhihao; Zhang, Yingying; Fan, Chengpeng; Han, Song; Yin, Jun; Peng, Biwen; Liu, Wanhong; He, Xiaohua

    2014-04-01

    Enterovirus 71 (EV71) is a neurotropic virus that causes various clinical manifestations in young children, ranging from asymptomatic to fatal. Different pathotypes of EV71 notably differ in virulence. Several virulence determinants of EV71 have been predicted. However, these reported virulence determinants could not be used to identify the EV71 strains of subgenotype C4, which mainly circulate in China. In this study, VP1 sequences of 37 EV71 strains from severe cases (SC-EV71) and 192 EV71 strains from mild cases (MC-EV71) in mainland China were analyzed to determine the potential virulence determinants in the capsid protein VP1 of EV71. Although most SC-EV71 strains belonged to subgenotype C4a, no specific genetic lineages in C4a were correlated with EV71 virulence. Interestingly, amino acid substitutions at nine positions (H22Q, P27S, N31S/D, E98K, E145G/Q, D164E, T240A/S, V249I, and A289T) were detected by aligning the VP1 sequences of the SC-EV71 and MC-EV71 strains. Moreover, both the constituent ratios of the conservative or mutated residues in the MC-EV71 and SC-EV71 strains and the changes in the VP1 3D structure resulting from these mutations confirmed that the conservative residues (22H, 249V, and 289A) and the mutated residues (27S, 31S/D, 98K, 145G/Q, 164E, and 240A/S) might be potential virulence determinants in VP1 of EV71. Furthermore, these results led to the hypothesis that VP1 acts as a sandwich switch for viral particle stabilization and cellular receptors attachment, and specific mutations in this protein can convert mild cases into severe cases. These findings highlight new opportunities for diagnostic and therapeutic interventions.

  2. How much are Chevrolet Volts in The EV Project driven in EV Mode?

    Energy Technology Data Exchange (ETDEWEB)

    John Smart

    2013-08-01

    This report summarizes key conclusions from analysis of data collected from Chevrolet Volts participating in The EV Project. Topics include how many miles are driven in EV mode, how far vehicles are driven between charging events, and how much energy is charged from the electric grid per charging event.

  3. 肠道病毒EV71

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    肠道病毒EV71感染疾病是由肠道病毒EV71引起的传染病,多发生于婴幼儿,尤以3岁以下年龄组发病率最高,可引起手、足、口腔等部位的疱疹,个别患者可引起心肌炎、肺水肿、无菌性脑膜脑炎等并发症。

  4. EV71 vaccine, an invaluable gift for children.

    Science.gov (United States)

    Liang, Zhenglun; Wang, Junzhi

    2014-10-01

    Enterovirus 71 (EV71) is a major pathogen for severe hand, foot and mouth disease (HFMD). Development of vaccines against EV71 would be the most effective approach to prevent the EV71 outbreak. Research and development (R&D) of EV71 vaccine was carried out in several Asian countries. Currently three companies in mainland China have completed Phase III clinical trials of inactivated EV71 whole-virus vaccines, whereas the other two companies have completed Phase I clinical trials separately in Taiwan and in Singapore. Results from those clinical trials have indicated high safety and immunogenicity of EV71 vaccine. Protective efficacies were over 90% on EV71-associated HFMD and over 80% on other EV71-associated diseases. In this paper, we summarize the results from three EV71 vaccine Phase III clinical trials and discuss the challenges of incorporating EV71 vaccine into Expanded Program on Immunization (EPI) in countries with EV71 epidemics.

  5. Presidendi sünnipäev

    Index Scriptorium Estoniae

    2003-01-01

    Milliseid mõtteid või mälestusi tekitab Teis president Arnold Rüütli 75. juubelisünnipäev? Vastavad: Toivo Tootsen, Peeter Kreitzberg, Toomas Varek, Heiki Männik, Paavo Palk, Mai Vöörmann, Andres Keevallik

  6. Alkoholentwöhnung im Verbundsystem (EVS)

    OpenAIRE

    Tielking, Knut Hrsg; Kuß, Gabriele Hrsg.

    2002-01-01

    Die Landesversicherungsanstalt (LVA) Oldenburg-Bremen und die Carl von Ossietzky-Universität Oldenburg verfolgen mit dem Modellprojekt 'Alkoholentwöhnung im Verbundsystem (EVS)' das gemeinsame Ziel, die Qualität von Alkoholentwöhnungsbehandlungen zu verbessern und noch wirkungsvoller zu gestalten. Der Eröffnungsbericht ist eine Zwischenbilanz der bisherigen Arbeiten des Modellprojekts.

  7. Volatile Survival on Near-Earth Asteroid 2008 EV5

    Science.gov (United States)

    Pohl, Leos; Britt, Daniel

    2016-10-01

    Asteroid 2008 EV5 is currently one of the possible targets of NASA Asteroid Redirect Mission (ARM). The objective of this mission is to recover a boulder from the surface of an asteroid. The selection of the final target requires understanding the physical characteristics of the asteroid such as the size-frequency distribution of boulders on the asteroid's surface, the presence of volatiles on the surface and below, the strength of the surface materials and the degree of their alteration. In our work, we focus on the second criterion, the possibility of volatiles presence on 2008 EV5. These can be expected to survive embedded within the crystal lattice of various phyllosilicates. The positive presence of volatiles on the surface of and inside the asteroid is important especially for ISRU hardware demonstrations. Spectral data suggest that 2008 EV5 is a member of CI chondrite group which is characterized by high phyllosilicate content (~70%) but there is also the possibility of it being a CR chondrite where the phyllosilicate content ranges significantly, from samples with negligible phyllosilicate content to samples with almost 70% phyllosilicate content. If the dynamical history of the asteroid brought it close enough to the Sun, the lattice of phyllosilicates could have disintegrated and released the volatiles (water) and the material could have dehydrated. The depth at which the dehydration might have taken place depends on the characteristic depth of heat wave penetration which in turn depends on material characteristics such as density, heat capacity and heat conductivity. These are in turn are closely linked to the porosity. The characteristic heat penetration depth also depends on orbital geometry and rotational and orbital periods. Besides the temperature itself, the dehydration is also affected by the duration of the crystal lattice breakup temperatures. We use thermal model in conjunction with available experimental data on the dehydration of clays and

  8. Ratio of the 10BF3 and 3He(n,p) cross sections between 0.025 eV and 25,000 eV

    International Nuclear Information System (INIS)

    The /sup 10/BF/sub 3/(n,/alpha/) and /sup 3/He(n,p) cross sections have been compared in the energy range from 0.025 to 25,000 eV. Measurements at National Bureau of Standards using filtered beams gave results at 2 and 25 keV. At the Oak Ridge National Laboratory using the ORELA facility measurements were completed between 0.025 and 10,000 eV. Normalizing the ratio of BF/sub 3//He to 1 at 0.03 eV, the ratio increases by 1% at 10 eV, by 2% at a few hundred ev, by 4% at 2 kev, and by 16% at 25 keV. The large deviations at the higher energies are expected purely from the nuclear parameterization of the cross sections. However, the deviations from 1/v in the ratio below 100 ev are surprising and perhaps might have their origin in the molecular binding for /sup 10/B in the /sup 10/BF/sub 3/ system. 8 refs

  9. NANO-BATTERY TECHNOLOGY FOR EV-HEV PANEL: A PIONEERING STUDY

    OpenAIRE

    Ataur Rahman; M Rashid; A K M Mohiuddin; M. N. A. Hawlader

    2015-01-01

    Global trends toward CO2 reduction and resource efficiency have significantly increased the importance of lightweight materials for automobile original equipment manufacturers (OEM). CO2 reduction is a fundamental driver for a more lightweight automobile. The introduction of Electrical Vehicles (EVs) is one initiative towards this end. However EVs are currently facing several weaknesses: limited driving range, battery pack heaviness, lack of safety and thermal control, high cost, and overall ...

  10. How Do The EV Project Participants Feel about Charging Their EV at Home?

    Energy Technology Data Exchange (ETDEWEB)

    Francfort, James E. [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2015-02-01

    Key Observations from the Survey of the EV Project Participants; In June 2013, 72% of EV Project participants were very satisfied with their home charging experience; 21% of participants relied totally on home charging for all of their charging needs; Volt owners relied more on home charging than Leaf owners, who reported more use of away-from-home charging; 74% of participants reported that they plug in their plug-in electric vehicle (PEV) every time they park at home. Others plugged in as they determined necessary to support their driving needs; 40% of participants reported that they would not have or are unsure that in June 2013 whether they would have purchased an alternating current (AC) Level 2 electric vehicle supply equipment (EVSE) for home charging if it had not been provided by The EV Project; and 61% of participants reported that The EV Project incentive was very important or important in their decision to obtain a PEV.

  11. Inherited MST1 deficiency underlies susceptibility to EV-HPV infections.

    Directory of Open Access Journals (Sweden)

    Amandine Crequer

    Full Text Available Epidermodysplasia verruciformis (EV is characterized by persistent cutaneous lesions caused by a specific group of related human papillomavirus genotypes (EV-HPVs in otherwise healthy individuals. Autosomal recessive (AR EVER1 and EVER2 deficiencies account for two thirds of known cases of EV. AR RHOH deficiency has recently been described in two siblings with EV-HPV infections as well as other infectious and tumoral manifestations. We report here the whole-exome based discovery of AR MST1 deficiency in a 19-year-old patient with a T-cell deficiency associated with EV-HPV, bacterial and fungal infections. MST1 deficiency has recently been described in seven patients from three unrelated kindreds with profound T-cell deficiency and various viral and bacterial infections. The patient was also homozygous for a rare ERCC3 variation. Our findings broaden the clinical range of infections seen in MST1 deficiency and provide a new genetic etiology of susceptibility to EV-HPV infections. Together with the recent discovery of RHOH deficiency, they suggest that T cells are involved in the control of EV-HPVs, at least in some individuals.

  12. EVS25,Calls for Sustainable Mobility Revolution

    Institute of Scientific and Technical Information of China (English)

    Yang Wei; Li Yinghong

    2009-01-01

    @@ Want to low your cost and save energy for your car,and also be environmentfriendly in nearby future? May you can find an answer in Zhenshen,Guangdong province,China,where the 25th world battery,hybrid and fuel cell electric vehicle symposium and exhibition (EVS25) will be held.The special event will last from November 5 to 9,2010,and is expected to attract 2000-2500 visitors,with an exhibition size of 30 thousand square meters,the largest in all the sessions held.

  13. X-ray Flares of EV Lac: Statistics, Spectra, Diagnostics

    CERN Document Server

    Huenemoerder, David P; Testa, Paola; Drake, Jeremy J; Osten, Rachel A; Reale, Fabio

    2010-01-01

    We study the spectral and temporal behavior of X-ray flares from the active M-dwarf EV Lac in 200 ks of exposure with the Chandra/HETGS. We derive flare parameters by fitting an empirical function which characterizes the amplitude, shape, and scale. The flares range from very short (<1 ks) to long (10 ks) duration events with a range of shapes and amplitudes for all durations. We extract spectra for composite flares to study their mean evolution and to compare flares of different lengths. Evolution of spectral features in the density-temperature plane shows probable sustained heating. The short flares are significantly hotter than the longer flares. We determined an upper limit to the Fe K fluorescent flux, the best fit value being close to what is expected for compact loops.

  14. EV71 vaccine, an invaluable gift for children

    OpenAIRE

    Liang, Zhenglun; Wang, Junzhi

    2014-01-01

    Enterovirus 71 (EV71) is a major pathogen for severe hand, foot and mouth disease (HFMD). Development of vaccines against EV71 would be the most effective approach to prevent the EV71 outbreak. Research and development (R&D) of EV71 vaccine was carried out in several Asian countries. Currently three companies in mainland China have completed Phase III clinical trials of inactivated EV71 whole-virus vaccines, whereas the other two companies have completed Phase I clinical trials separately in ...

  15. Enhanced Video Surveillance (EVS) with speckle imaging

    Energy Technology Data Exchange (ETDEWEB)

    Carrano, C J

    2004-01-13

    Enhanced Video Surveillance (EVS) with Speckle Imaging is a high-resolution imaging system that substantially improves resolution and contrast in images acquired over long distances. This technology will increase image resolution up to an order of magnitude or greater for video surveillance systems. The system's hardware components are all commercially available and consist of a telescope or large-aperture lens assembly, a high-performance digital camera, and a personal computer. The system's software, developed at LLNL, extends standard speckle-image-processing methods (used in the astronomical community) to solve the atmospheric blurring problem associated with imaging over medium to long distances (hundreds of meters to tens of kilometers) through horizontal or slant-path turbulence. This novel imaging technology will not only enhance national security but also will benefit law enforcement, security contractors, and any private or public entity that uses video surveillance to protect their assets.

  16. Proteomics analysis of EV71-infected cells reveals the involvement of host protein NEDD4L in EV71 replication.

    Science.gov (United States)

    Kuo, Rei-Lin; Lin, Ya-Han; Wang, Robert Yung-Liang; Hsu, Chia-Wei; Chiu, Yi-Ting; Huang, Hsing-I; Kao, Li-Ting; Yu, Jau-Song; Shih, Shin-Ru; Wu, Chih-Ching

    2015-04-01

    Enterovirus 71 (EV71) is a human enterovirus that has seriously affected the Asia-Pacific area for the past two decades. EV71 infection can result in mild hand-foot-and-mouth disease and herpangina and may occasionally lead to severe neurological complications in children. However, the specific biological processes that become altered during EV71 infection remain unclear. To further explore host responses upon EV71 infection, we identified proteins differentially expressed in EV71-infected human glioblastoma SF268 cells using isobaric mass tag (iTRAQ) labeling coupled with multidimensional liquid chromatography-mass spectrometry (LC-MS/MS). Network analysis of proteins altered in cells infected with EV71 revealed that the changed biological processes are related to protein and ion transport, regulation of protein degradation, and homeostatic processes. We confirmed that the levels of NEDD4L and PSMF1 were increased and reduced, respectively, in EV71-infected cells compared to mock-infected control cells. To determine the physiological relevance of our findings, we investigated the consequences of EV71 infection in cells with NEDD4L or PSMF1 depletion. We found that the depletion of NEDD4L significantly reduced the replication of EV71, whereas PSMF1 knockdown enhanced EV71 replication. Collectively, our findings provide the first evidence of proteome-wide dysregulation by EV71 infection and suggest a novel role for the host protein NEDD4L in the replication of this virus.

  17. Crew coordination issues of EVS approaches

    Science.gov (United States)

    Lorenz, Bernd; Korn, Bernd R.

    2004-08-01

    Enhanced Vision Systems (EVS) are currently developed with the goal to alleviate restrictions in airspace and airport capacity in low visibility conditions. Existing EVS-systems are based on IR-sensors although the penetration of bad weather (dense fog and light rain) by MMW-radar is remarkably better than in the infrared spectrum. But the quality of MMW radar is rather poor compared to IR images. However, the analysis of radar images can be simplified dramatically when simple passive radar retro-reflectors are used to mark the runway. This presentation is the third in a series of studies investigating the use of such simple landing aids. In the first study the feasibility of the radar PAPI concept was determined; the second one provided first promising human performance results in a low-fidelity simulation. The present study examined pilot performance, workload, situation awareness, and crew coordination issues in a high-fidelity simulation of 'Radar-PAPI' visual aids supporting a precision straight-in landing in low visibility (CAT-II). Simulation scenarios were completed in a fixed-base cockpit simulator involving six two-pilot flight-deck crews. Pilots could derive visual cues to correct lateral glide-path deviations from 13 pairs of runway-marking corner reflectors. Vertical deviations were indicated by a set of six diplane reflectors using intensity-coding to provide the PAPI categories needed for the correction of vertical deviations. The study compared three display formats and associated crew coordination issues: (1) PF views a head-down B-scope display and switches to visual landing upon PNF's call-out that runway is in sight; (2) PF views a head-down C-scope display and switches to visual landing upon PNF's call-out that runway is in sight; (3) PF views through a head-up display (HUD) that displays primary flight guidance information and receives vertical and lateral guidance from PNF who views a head-down B-scope. PNF guidance is terminated upon PF

  18. Human SCARB2-mediated entry and endocytosis of EV71.

    Directory of Open Access Journals (Sweden)

    Yi-Wen Lin

    Full Text Available Enterovirus (EV 71 infection is known to cause hand-foot-and-mouth disease (HFMD and in severe cases, induces neurological disorders culminating in fatality. An outbreak of EV71 in South East Asia in 1997 affected over 120,000 people and caused neurological disorders in a few individuals. The control of EV71 infection through public health interventions remains minimal and treatments are only symptomatic. Recently, human scavenger receptor class B, member 2 (SCARB2 has been reported to be a cellular receptor of EV71. We expressed human SCARB2 gene in NIH3T3 cells (3T3-SCARB2 to study the mechanisms of EV71 entry and infection. We demonstrated that human SCARB2 serves as a cellular receptor for EV71 entry. Disruption of expression of SCARB2 using siRNAs can interfere EV71 infection and subsequent inhibit the expression of viral capsid proteins in RD and 3T3-SCARB2 but not Vero cells. SiRNAs specific to clathrin or dynamin or chemical inhibitor of clathrin-mediated endocytosis were all capable of interfering with the entry of EV71 into 3T3-SCARB2 cells. On the other hand, caveolin specific siRNA or inhibitors of caveolae-mediated endocytosis had no effect, confirming that only clathrin-mediated pathway was involved in EV71 infection. Endocytosis of EV71 was also found to be pH-dependent requiring endosomal acidification and also required intact membrane cholesterol. In summary, the mechanism of EV71 entry through SCARB2 as the receptor for attachment, and its cellular entry is through a clathrin-mediated and pH-dependent endocytic pathway. This study on the receptor and endocytic mechanisms of EV71 infection is useful for the development of effective medications and prophylactic treatment against the enterovirus.

  19. Effects of electric vehicles (EV) on environmental loads with consideration of regional differences of electric power generation and charging characteristics of EV users in Japan

    International Nuclear Information System (INIS)

    In order to evaluate the reduction effect of electric vehicles (EVs) on various atmospheric environmental loads, we have performed a life-cycle inventory analysis (LCI), including the installation of charging stations and regional, seasonal and temporal difference of the energy mix of electricity generation. For an EV converted from a small gasoline vehicle, a regional LCI analysis was carried out in the following steps: (1) location of the charging stations, (2) modeling of charging characteristics of station users, (3) calculation of temporal life-cycle emission intensities of CO2, NOx and SOx by region, season and day. Assuming that total traveling distance is 100,000 km, the electricity consumption rate is 0.119 kWh/km and the charging/discharging efficiency is 70%, the average life-cycle emission of CO2 for that EV was 3.6 t-C throughout Japan. However, if we took regional difference into account, the emission ranged over 70-160% of the average amount. It was revealed that the regional difference of the primary energy mix significantly affected the emissions of EVs during the operation phase. (Author)

  20. Fluoresence Detection of Cosmic Ray Air Showers Between 10 16 . 5 eV and 1019 eV with the Telescope Array Low Energy Extension (TALE)

    Science.gov (United States)

    Zundel, Zachary; Smith, Jeremy; Thomas, Stan; Abuzayyad, Tareq; Ivanov, Dmitri; Matthews, John; Jui, Charlie

    2014-03-01

    The Telescope Array Experiment has been observing cosmic ray air showers at energies above 1018 eV since 2008. TA operates three Fluorescence Detector (FD) sites, with telescopes that observe 3-31 deg in elevation. The FD sites are located at the periphery of a surface array of 507 scintillation counters covering 700 km2 , with 1.2 km spacing. The TA Collaboration has completed building a low-energy extension at its Middle drum FD site. Ten new telescopes currently observe between 33 and 51 degrees in elevation. A graded ground array of between 400 and 600m will be placed in front of the TALE FD. With these upgrades, the physics threshold of TA will be lowered to 10 16 . 5 eV. The TA Low Energy Extension (TALE) will explore the energy regime corresponding to that of the LHC in center-of-mass frame. This is also the range where the transition from galactic to extra- galactic cosmic ray flux is suspected to occur. We will give a brief overview of the physics, and report on the progress of TALE toward measuring the cosmic ray spectrum between 10 16 . 5 eV and 1019 eV.

  1. Potentials and capabilities of the Extracellular Vesicle (EV) Array

    DEFF Research Database (Denmark)

    Jørgensen, Malene Møller; Bæk, Rikke; Varming, Kim

    2015-01-01

    Extracellular vesicles (EVs) and exosomes are difficult to enrich or purify from biofluids, hence quantification and phenotyping of these are tedious and inaccurate. The multiplexed, highly sensitive and high-throughput platform of the EV Array presented by Jørgensen et al., (J Extracell Vesicles......, 2013; 2: 10) has been refined regarding the capabilities of the method for characterization and molecular profiling of EV surface markers. Here, we present an extended microarray platform to detect and phenotype plasma-derived EVs (optimized for exosomes) for up to 60 antigens without any enrichment...

  2. Driving Pattern Analysis for Electric Vehicle (EV) Grid Integration Study

    DEFF Research Database (Denmark)

    Wu, Qiuwei; Nielsen, Arne Hejde; Østergaard, Jacob;

    2010-01-01

    In order to facilitate the integration of electric vehicles (EVs) into the Danish power system, the driving data in Denmark were analyzed to extract the information of driving distances and driving time periods which were used to represent the driving requirements and the EV unavailability...... from the driving time periods to show how many cars are available for charging and discharging in each time period. The obtained EV availability data are in one hour time periods and one quarter time periods for different study purposes. The EV availability data of one hour time period are to be used...

  3. Potentials and capabilities of the Extracellular Vesicle (EV Array

    Directory of Open Access Journals (Sweden)

    Malene Møller Jørgensen

    2015-04-01

    Full Text Available Extracellular vesicles (EVs and exosomes are difficult to enrich or purify from biofluids, hence quantification and phenotyping of these are tedious and inaccurate. The multiplexed, highly sensitive and high-throughput platform of the EV Array presented by Jørgensen et al., (J Extracell Vesicles, 2013; 2: 10 has been refined regarding the capabilities of the method for characterization and molecular profiling of EV surface markers. Here, we present an extended microarray platform to detect and phenotype plasma-derived EVs (optimized for exosomes for up to 60 antigens without any enrichment or purification prior to analysis.

  4. Electric Vehicle (EV) Charging Management with Dynamic Distribution System Tariff

    DEFF Research Database (Denmark)

    O'Connell, Niamh; Wu, Qiuwei; Østergaard, Jacob;

    2011-01-01

    An electric vehicle (EV) charging schedule algorithm was proposed in this paper in order to charge EVs to meet EV users’ driving needs with the minimum EV charging cost and respect the local distribution system constraints. A day-ahead dynamic distribution system tariff scheme was proposed to avoid...... congestions in local distribution systems from the day-ahead planning perspective. Locational marginal pricing method was used to determine the dynamic distribution system tariff based on predicted day-ahead spot prices and predicted charging behaviors. Distribution grids of the Bornholm power system were...

  5. Energy levels of Th+ between 7.3 and 8.3 eV

    CERN Document Server

    Herrera-Sancho, O A; Okhapkin, M V; Peik, E

    2013-01-01

    Using resonant two-step laser excitation of trapped 232Th+ ions, we observe 43 previously unknown energy levels within the energy range from 7.3 to 8.3 eV. The high density of states promises a strongly enhanced electronic bridge excitation of the 229mTh nuclear state that is expected in this energy range. From the observation of resonantly enhanced three-photon ionization of Th+, the second ionization potential of thorium can be inferred to lie within the range between 11.9 and 12.3 eV. Pulsed laser radiation in a wide wavelength range from 237 to 289 nm is found to provide efficient photodissociation of molecular ions that are formed in reactions of Th+ with impurities in the buffer gas, leading to a significantly increased storage time for Th+ in the ion trap.

  6. Electron scattering from molecule CH4 at 10-5000eV

    Institute of Scientific and Technical Information of China (English)

    刘玉芳; 朱遵略; 孙金锋; 丛书林; 韩克利

    2003-01-01

    Electron scattering from molecules in the intermediate- and high-energy range is investigated employing the devel-oped semi-empirical formula for electron scattering from diatomic molecules. Total cross sections of e-CH4 scatteringare obtained over an incident energy range of 10-5000eV. The results agree well with other available experimental andtheoretical data. According to our formula, some quantitative information of single Yukawa potential are also obtained.

  7. Weighted (C)eby(s)ev-Ostrowski type inequalities

    Institute of Scientific and Technical Information of China (English)

    Arif Rafiq; Nazir Ahmad Mir; Farooq Ahmad

    2007-01-01

    In account of the famous (C)eby(s)ev inequality, a rich theory has appeared in the literature. We establish some new weighted (C)eby(s)ev type integral inequalities. Our proofs are of independent interest and provide new estimates on these types of inequalities.

  8. Vabariigi aastapäev Ottawas / Walter Pent

    Index Scriptorium Estoniae

    Pent, Walter

    2004-01-01

    EV 86. aastapäeva puhul toimus 21. veebr. 2004 Ottawa Eesti Seltsi organiseeritud aktus, kus kõne pidas EV Suursaatkonna Ottawas asjur Argo Küünemäe, kes korraldas 24. veebr. 2004 saatkonnas ka piduliku diplomaatilise vastuvõtu

  9. Development of EV71 virus-like particle purification processes.

    Science.gov (United States)

    Lin, Shih-Yeh; Chiu, Hsin-Yi; Chiang, Bor-Luen; Hu, Yu-Chen

    2015-11-01

    Enterovirus 71 (EV71) causes the outbreaks of hand-foot-and-mouth disease and results in deaths of hundreds of young children. EV71 virus-like particles (VLPs) are empty capsids consisting of viral structural proteins and can elicit potent immune responses, thus holding promise as an EV71 vaccine candidate. However, an efficient, scalable production and purification scheme is missing. For mass production of EV71 VLPs, this study aimed to develop a production and chromatography-based purification process. We first demonstrated the successful EV71 VLPs production in the stirred-tank bioreactor in which High Five™ cells were infected with a recombinant baculovirus co-expressing EV71 structural polyprotein P1 and protease 3CD. The culture supernatant containing the VLPs was subjected to tangential flow filtration (TFF) for concentration/diafiltration, which enabled the removal of >80% of proteins while recovering >80% of VLPs. The concentrated VLPs were next subjected to hydroxyapatite chromatography (HAC) in which the VLPs were mainly found in the flow through. After another TFF concentration/diafiltration, the VLPs were purified by size-exclusion chromatography (SEC) and concentrated/diafiltered by a final TFF. The integrated process yielded an overall VLPs recovery of ≈ 36% and a purity of ≈ 83%, which was better or comparable to the recovery and purity for the purification of live EV71 virus particles. This process thus may move the EV71 VLPs vaccine one step closer to the clinical applications.

  10. Operation Strategy of EV Battery Charging and Swapping Station

    Institute of Scientific and Technical Information of China (English)

    Zhuo Peng; Li Zhang; Ku-An Lu; Jun-Peng Hu; Si Liu

    2014-01-01

    An operation strategy of the electric vehicle (EV) battery charging and swapping station is proposed in the paper. The strategy is established based on comprehensively consideration of the EV charging behaviors and the possible mutual actions between battery charging and swapping. Three energy management strategies can be used in the station:charging period shifting, energy exchange between EVs, and energy supporting from surplus swapping batteries. Then an optimization model which minimizes the total energy management costs of the station is built. The Monte Carlo simulation is applied to analyze the characteristics of the EV battery charging load, and a heuristic algorithm is used to solve the strategy providing the relevant information of EVs and the battery charging and swapping station. The operation strategy can efficiently reduce battery charging during the high electricity price periods and make more reasonable use of the resources. Simulations prove the feasibility and rationality of the strategy.

  11. Fission Fragment Folding Angle Distributions for the Systems sup 1 sup 1 B+ sup 2 sup 3 sup 7 Np, sup 1 sup 2 C+ sup 2 sup 3 sup 6 U, and sup 1 sup 6 O+ sup 2 sup 3 sup 2 Th in the Energy Range 1.1<E/V sub B <2.1

    CERN Document Server

    Kailas, S; Chatterjee, A; Saxena, A; Kapoor, S S; Vandenbosch, R; Lestone, J P; Liang, J F; Prindle, D J; Sonzogni, A A; Bierman, J D

    1999-01-01

    Fission fragment folding angle distributions have been measured for the systems sup 1 sup 1 B+ sup 2 sup 3 sup 7 Np, sup 1 sup 2 C+ sup 2 sup 3 sup 6 U, and sup 1 sup 6 O+ sup 2 sup 3 sup 2 Th, populating the same compound nucleus ( sup 2 sup 4 sup 8 Cf) and at similar excitation energies (E sub x 45-100 MeV). The full momentum transfer and incomplete momentum transfer fusion-fission components have been separated over the bombarding energy range 1.1T) and with smaller fission barriers (B sub f >T). It was interesting to find that the effective moment of inertia (J sub e sub f sub f) values deduced from the latter component were consistent with the values from Sierk prescription used in the former case

  12. NANO-BATTERY TECHNOLOGY FOR EV-HEV PANEL: A PIONEERING STUDY

    Directory of Open Access Journals (Sweden)

    Ataur Rahman

    2015-11-01

    Full Text Available Global trends toward CO2 reduction and resource efficiency have significantly increased the importance of lightweight materials for automobile original equipment manufacturers (OEM. CO2 reduction is a fundamental driver for a more lightweight automobile. The introduction of Electrical Vehicles (EVs is one initiative towards this end. However EVs are currently facing several weaknesses: limited driving range, battery pack heaviness, lack of safety and thermal control, high cost, and overall limited efficiency. This study presents a panel-style nano-battery technology built into an EV with CuO filler solid polymer electrolyte (SPE sandwiched by carbon fiber (CF and lithium (Li plate. In addition to this, an aluminum laminated polypropylene film is used as the electromagnetic compatibility (EMC shield. The proposed battery body panel of the EV would reduce the car weight by about 20%, with a charge and discharge capacity of 1.5 kWh (10% of car total power requirement, and provide the heat insulation for the car which would save about 10% power consumption of the air conditioning system. Therefore, the EV would be benefited by 30% in terms of energy reduction by using the proposed body. Furthermore, the proposed body is considered environmental-friendly since it is recyclable for use in a new product. However, the main limiting factors of the SPE are its thermal behavior and moderate ionic conductivity at low temperatures. The SPE temperature is maintained by controlling the battery panel charging/discharge rate. It is expected that the proposed panel-style nano-battery use in an EV would save up to 6.00 kWh in battery energy, equivalent to 2.81 liters of petrol and prevent 3.081 kg of CO2 emission for a travel distance of 100 km. KEYWORDS: epoxy resin; carbon fiber; lithium thin plate; energy generation; solid electrolyte battery

  13. An adenosine nucleoside analogue NITD008 inhibits EV71 proliferation.

    Science.gov (United States)

    Shang, Luqing; Wang, Yaxin; Qing, Jie; Shu, Bo; Cao, Lin; Lou, Zhiyong; Gong, Peng; Sun, Yuna; Yin, Zheng

    2014-12-01

    Enterovirus 71 (EV71), one of the major causative agents of Hand-Foot-Mouth Disease (HFMD), causes severe pandemics and hundreds of deaths in the Asia-Pacific region annually and is an enormous public health threat. However, effective therapeutic antiviral drugs against EV71 are rare. Nucleoside analogues have been successfully used in the clinic for the treatment of various viral infections. We evaluated a total of 27 nucleoside analogues and discovered that an adenosine nucleoside analogue NITD008, which has been reported to be an antiviral reagent that specifically inhibits flaviviruses, effectively suppressed the propagation of different strains of EV71 in RD, 293T and Vero cells with a relatively high selectivity index. Triphosphorylated NITD008 (ppp-NITD008) functions as a chain terminator to directly inhibit the RNA-dependent RNA polymerase activity of EV71, and it does not affect the EV71 VPg uridylylation process. A significant synergistic anti-EV71 effect of NITD008 with rupintrivir (AG7088) (a protease inhibitor) was documented, supporting the potential combination therapy of NITD008 with other inhibitors for the treatment of EV71 infections.

  14. HiggsToFourLeptonsEV in the ATLAS EventView Analysis Framework

    CERN Document Server

    Lagouri, T; Del Peso, J

    2008-01-01

    ATLAS is one of the four experiments at the Large Hadron Collider (LHC) at CERN. This experiment has been designed to study a large range of physics topics, including searches for previously unobserved phenomena such as the Higgs Boson and super-symmetry. The physics analysis package HiggsToFourLeptonsEV for the Standard Model (SM) Higgs to four leptons channel with ATLAS is presented. The physics goal is to investigate with the ATLAS detector, the SM Higgs boson discovery potential through its observation in the four-lepton (electron and muon) final state. HiggsToFourLeptonsEV is based on the official ATLAS software ATHENA and the EventView (EV) analysis framework. EventView is a highly flexible and modular analysis framework in ATHENA and it is one of several analysis schemes for ATLAS physics user analysis. At the core of the EventView is the representative view of an event, which defines the contents of event data suitable for event-level physics analysis. The HiggsToFourLeptonsEV package prepares the dat...

  15. HiggsToFourLeptonsEV in the ATLAS EventView Analysis Framework

    CERN Document Server

    Lagouri, T; Del Peso, J

    2008-01-01

    ATLAS is one of the four experiments at the Large Hadron Collider (LHC) at CERN. This experiment has been designed to study a large range of physics topics, including searches for previously unobserved phenomena such as the Higgs Boson and super-symmetry. The physics analysis package HiggsToFourLeptonsEV for the Standard Model (SM) Higgs to four leptons channel with ATLAS is presented. The physics goal is to investigate with the ATLAS detector, the SM Higgs boson discovery potential through its observation in the four-lepton (electron and muon) final state. HiggsToFourLeptonsEV is based on the official ATLAS software ATHENA and the EventView (EV) analysis framework. EventView is a highly flexible and modular analysis framework in ATHENA and it is one of several analysis schemes for ATLAS physics user analysis. At the core of the EventView is the representative "view" of an event, which defines the contents of event data suitable for event-level physics analysis. The HiggsToFourLeptonsEV package, presented in ...

  16. EV71疫苗研究进展%Progress in the research of EV71 vaccine

    Institute of Scientific and Technical Information of China (English)

    蔡宏荣; 王蕾; 廖芸

    2009-01-01

    Enterovirus 71 (EV71) is a major etiological agent of hand-foot-and-mouth disease (HFMD). Since no effeetive antiviral agents are available,developing effective EV71 vaccines for prevention of HFMD has been the control measure of choice. Currently, the research of EV71 vaccines has made certain pro-gress,and various EV71 vaccines, including attenuated vccines, inactivated vaccine, VP1 subunit vaccine and DNA vaccine, are being developed. Although various EV71 vaccines have certain efficacy, the optimal vaccine needs to be identified by evaluating the safety and protective efficacy of various EV71 vaccines.%肠道病毒71型(enterovims 71,EV71)是手足口病的主要病原体,由于尚无治疗手足口病的有效抗病毒药,因此,开发预防手足口病的有效EV71疫苗成为所有控制措施的首选.目前,EV71疫苗研究已取得一定的进展,正在研发的疫苗包括减毒或灭活疫苗、VP1亚单位疫苗和DNA疫苗.虽然各种疫苗均具有一定的免疫效果,但最适疫苗的确认还需对各种疫苗的安全性和保护效力进行评估.

  17. Base fluid in improving heat transfer for EV car battery

    Science.gov (United States)

    Bin-Abdun, Nazih A.; Razlan, Zuradzman M.; Shahriman, A. B.; Wan, Khairunizam; Hazry, D.; Ahmed, S. Faiz; Adnan, Nazrul H.; Heng, R.; Kamarudin, H.; Zunaidi, I.

    2015-05-01

    This study examined the effects of base fluid (as coolants) channeling inside the heat exchanger in the process of the increase in thermal conductivity between EV car battery and the heat exchanger. The analysis showed that secondary cooling system by means of water has advantages in improving the heat transfer process and reducing the electric power loss on the form of thermal energy from batteries. This leads to the increase in the efficiency of the EV car battery, hence also positively reflecting the performance of the EV car. The present work, analysis is performed to assess the design and use of heat exchanger in increasing the performance efficiency of the EV car battery. This provides a preface to the use this design for nano-fluids which increase and improve from heat transfer.

  18. National Greenhouse Gas Emission Inventory (EV-GHG)

    Data.gov (United States)

    U.S. Environmental Protection Agency — The EV-GHG Mobile Source Data asset contains measured mobile source GHG emissions summary compliance information on light-duty vehicles, by model, for certification...

  19. EBSCO infopäev Tallinnas / Marika Meltsas

    Index Scriptorium Estoniae

    Meltsas, Marika

    2008-01-01

    16. aprillil 2008 toimus Tallinnas EBSCO (Elton B. Stephens Company) infopäev, kus maailma suurim elektrooniliste ja trükiajakirjade vahendaja tutvustas oma tooteid ja teenuseid Eesti raamatukogudele. Kommentaar korraldajalt Tiina Nurmilt

  20. Immunological Evaluation and Comparison of Different EV71 Vaccine Candidates

    Directory of Open Access Journals (Sweden)

    Ai-Hsiang Chou

    2012-01-01

    Full Text Available Enterovirus 71 (EV71 and coxsackievirus A16 (CVA16 are major causative agents of hand, foot, and mouth diseases (HFMDs, and EV71 is now recognized as an emerging neurotropic virus in Asia. Effective medications and/or prophylactic vaccines against HFMD are not available. The current results from mouse immunogenicity studies using in-house standardized RD cell virus neutralization assays indicate that (1 VP1 peptide (residues 211–225 formulated with Freund’s adjuvant (CFA/IFA elicited low virus neutralizing antibody response (1/32 titer; (2 recombinant virus-like particles produced from baculovirus formulated with CFA/IFA could elicit good virus neutralization titer (1/160; (3 individual recombinant EV71 antigens (VP1, VP2, and VP3 formulated with CFA/IFA, only VP1 elicited antibody response with 1/128 virus neutralization titer; and (4 the formalin-inactivated EV71 formulated in alum elicited antibodies that cross-neutralized different EV71 genotypes (1/640, but failed to neutralize CVA16. In contrast, rabbits antisera could cross-neutralize strongly against different genotypes of EV71 but weakly against CVA16, with average titers 1/6400 and 1/32, respectively. The VP1 amino acid sequence dissimilarity between CVA16 and EV71 could partially explain why mouse antibodies failed to cross-neutralize CVA16. Therefore, the best formulation for producing cost-effective HFMD vaccine is a combination of formalin-inactivated EV71 and CAV16 virions.

  1. Electron inelastic interactions in bioorganic compounds in the energy range of 20 10000 eV

    Science.gov (United States)

    Tan, Z.; Xia, Y.; Liu, X.; Zhao, M.; Ji, Y.; Li, F.; Huang, B.

    2005-09-01

    Systematic calculations of stopping powers (SPs) and mean free paths (MFPs) for 10 bioorganic compounds have been performed for electrons with energies lower than 10 keV, based on dielectric response theory and Penn’s statistical approximation. The exchange effect is also taken into account in the calculations. An empirical approach to obtain an optical energy loss function is presented for those organic compounds without available optical data. Using this method, the calculated values of the optical energy loss function are in good agreement with experimental data. Comparisons of SP and MFP values derived in this study with other published values are presented. Using the described model, the calculated mean ionization potentials agree well with the predictions from Bragg’s rule and the calculated SPs have also been compared with the Bethe Bloch results at an energy of 10 keV.

  2. Analysis of CDMA EV DO capacity%CDMA EV DO容量的分析研究

    Institute of Scientific and Technical Information of China (English)

    王俊

    2011-01-01

    With the development of CDMA EV DO technique, more and more subscribers are not satisfied with data link rate. This paper analyzes factors of forward link and reverse link capacity of EV DO network to guide network planning and optimization. The research in this field is to meet requirement of high speed data access and maximum throughput of data subscribers.%分析影响EV DO网络前、反向容量的因素,为CDMA EV DO数据业务网规网优提供方法论的指导,达到数据用户吞吐量的最大化,满足日益增长的多用户高速数据接入的需求.

  3. Järjekordne keelepäev Hamburgis (Emakeelepäev Hamburgis) I-III / Liilika M. Allev

    Index Scriptorium Estoniae

    Allev, Liilika M.

    2007-01-01

    seekord oli keskseks teemaks lapse keeleareng, korraldajateks EV Haridus- ja Teadusministeerium, Eesti Keeleinstituut ja EÜSLi HEA Selts. Keelepoliitikast. Kuidas eesti laps rääkima hakkab? Kakskeelsuse omandamine

  4. On search for eV hidden sector photons in Super-Kamiokande and CAST experiments

    Energy Technology Data Exchange (ETDEWEB)

    Gninenko, S.N. [Russian Academy of Sciences, Moscow (Russian Federation). Inst. for Nuclear Research; Redondo, J. [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany)

    2008-04-15

    If light hidden sector photons ({gamma}'s) exist, they could be produced through kinetic mixing with solar photons in the eV energy range. We propose to search for this hypothetical {gamma}'-flux with the Super-Kamiokande and/or upgraded CAST detectors. The proposed experiments are sensitive to the {gamma}-{gamma}' mixing strength as small as 10{sup -5}>or similar {chi}>or similar 10{sup -9} for the {gamma}'' mass region 10{sup -4} eV and, in the case of non-observation, would improve limits recently obtained from photon regeneration laser experiments for this mass region. (orig.)

  5. First isolation of enterovirus 71 (EV-71 from Northern Brazil

    Directory of Open Access Journals (Sweden)

    Lamarão Leticia Martins

    2003-01-01

    Full Text Available Enterovirus 71 (EV-71 has been associated to cases of neurological disease in many countries including Brazil. This virus has now been reported from three of the five Brazilian regions. Our study relates the findings concerning to the first isolate of this virus in Northern region of Brazil. A 15-month old female patient, from the rural zone of the municipality of Santana do Araguaia in southern Pará state was admitted at the hospital with acute, flaccid, asymmetric and ascending motor deficiency, located in the right lower limb. Stools samples from this child were inoculated in RD cells and was isolated an EV-71. We plan to sequence our strain and compare it to other isolates in Brazil. Differences at the molecular level can explain why EV-71 strains circulating in other continents, such as Asia, appear to be more virulent.

  6. ZGODBE V TUJEM JEZIKU IN VLOGA STARŠEV

    OpenAIRE

    Pušaver, Saša

    2016-01-01

    Zgodbe v tujem jeziku je empirično diplomsko delo, kjer predstavljamo zgodbe v tujem jeziku kot pripomoček za poučevanje tujega jezika v otroštvu. Osredotočamo se predvsem na vlogo staršev pri branju zgodb v tujem jeziku svojim otrokom. V empiričnem delu smo preverjali stališča staršev do branja zgodb v tujem jeziku svojim otrokom. Zaradi predvidevanja po upadu števila staršev, ki berejo svojim otrokom v tujem jeziku, smo sestavili tudi vprašanja za starše, ki zgodb v tujem jeziku svojim otro...

  7. Adaptative initialisation of a EvKNN classification algorithm

    OpenAIRE

    Chan Wai Tim, Stefen; Rombaut, Michele; Pellerin, Denis

    2012-01-01

    International audience; The establishment of the learning data base is a long and tedious task that must be carried out before starting the classification process. An Evidential KNN (EvKNN) has been developed in order to help the user, which proposes the "best" samples to label according to a strategy. However, at the beginning of this task, the classes are not clearly defined and are represented by a number of labeled samples smaller than the k required samples for EvKNN. In this paper, we p...

  8. KOMPETENTNOST STARŠEV ZA STARŠEVSKO VLOGO

    OpenAIRE

    Križan, Iris

    2016-01-01

    Diplomsko delo z naslovom Kompetentnost staršev za starševsko vlogo je sestavljeno iz teoretičnega in empiričnega dela. V teoretičnem delu so predstavljene različne teme, vezane na kompetentnost staršev za starševsko vlogo, ki so podkrepljene z ustrezno strokovno literaturo. Podrobno so opredeljeni pojem družina in njene oblike danes. Opisani so vzgojni stili, ki so podani glede na različne avtorje. V teoretičnem delu so predstavljene nove paradigme zgodnjega otroštva. Podrobno je opisano,...

  9. Modeling and Testing of EVs - Preliminary Study and Laboratory Development

    DEFF Research Database (Denmark)

    Yang, Guang-Ya; Marra, Francesco; Nielsen, Arne Hejde;

    2010-01-01

    impact at different geographical areas, as well as driving and charging patterns. Electric circuit model is deployed in this work to represent the electrical properties of a lithium-ion battery. This paper reports the preliminary modeling and validation work based on manufacturer data sheet and realistic......Electric vehicles (EVs) are expected to play a key role in the future energy management system to stabilize both supply and consumption with the presence of high penetration of renewable generation. A reasonably accurate model of battery is a key element for the study of EVs behavior and the grid...... tests, followed by the suggestions towards a feasible battery model for further studies....

  10. Optical properties of ZrZn2 from 0.6 to 3.8 eV

    NARCIS (Netherlands)

    Heide, P.A.M. van der; Baelde, W.; Groot, R.A. de; Vroomen, A.R. de; Mattocks, P.G.

    1984-01-01

    In this paper we report ellipsometry measurements on ZrZn2 at room temperature under ultra-high vacuum conditions. The optical constants have been determined in the energy range 0.6-3.8 eV. The results are compared with calculated optical conductivity curves based on recent band-structure calculatio

  11. Temperature dependence of photoconductivity at 0.7 eV in single-wall carbon nanotube films

    Directory of Open Access Journals (Sweden)

    Yukitaka Matsuoka, Akihiko Fujiwara, Naoki Ogawa, Kenjiro Miyano, Hiromichi Kataura, Yutaka Maniwa, Shinzo Suzuki and Yohji Achiba

    2003-01-01

    Full Text Available Temperature dependence of photoconductivity has been investigated for single-wall carbon nanotube films at 0.7 eV. In order to clarify the effect of atmosphere on photoconductivity, measurements have been performed under helium and nitrogen gas flow in the temperature range from 10 K to room temperature (RT and from 100 K to RT, respectively. Photoconductive response monotonously increases with a decrease in temperature and tends to saturate around 10 K. No clear difference in photoconductive response under different atmosphere was observed. We discuss the mechanism of photoconductivity at 0.7 eV.

  12. Mass Absorption Coefficient of Tungsten and Tantalum, 1450 eV to 2350 eV: Experiment, Theory, and Application

    OpenAIRE

    Levine, Zachary H.; Grantham, Steven; Tarrio, Charles; Paterson, David J.; McNulty, Ian; Levin, T. M.; Ankudinov, Alexei L.; Rehr, John J.

    2003-01-01

    The mass absorption coefficients of tungsten and tantalum were measured with soft x-ray photons from 1450 eV to 2350 eV using an undulator source. This region includes the M3, M4, and M5 absorption edges. X-ray absorption fine structure was calculated within a real-space multiple scattering formalism; the predicted structure was observed for tungsten and to a lesser degree tantalum as well. Separately, the effects of dynamic screening were observed as shown by an atomic calculation within the...

  13. CONSISTENCY OF LS ESTIMATOR IN SIMPLE LINEAR EV REGRESSION MODELS

    Institute of Scientific and Technical Information of China (English)

    Liu Jixue; Chen Xiru

    2005-01-01

    Consistency of LS estimate of simple linear EV model is studied. It is shown that under some common assumptions of the model, both weak and strong consistency of the estimate are equivalent but it is not so for quadratic-mean consistency.

  14. Global EV Outlook: Understanding the Electric Vehicle Landscape to 2020

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2013-06-01

    The Global EV Outlook represents the collective efforts of two years of primary data gathering and analysis from the Electric Vehicles Initiative (EVI) and IEA. Key takeaways and insights include landscape analysis of electric vehicle (EV) stock/sales and charging station deployment. Existing policy initiatives are delineated and future opportunities highlighted in an ''Opportunity Matrix: Pathways to 2020''. Together EVI countries accounted for more than 90% of world EV stock at the end of 2012. Strong government support in EVI countries on both the supply and demand sides are contributing to rising market penetration. 12 out of 15 EVI countries offer financial support for vehicle purchases, and most employ a mix of financial and non-financial incentives (such as access to restricted highway lanes) to help drive adoption. The Global EV Outlook is a unique and data-rich overview of the state of electric vehicles today, and offers an understanding of the electric vehicle landscape to 2020.

  15. Philosophical Adventures in the Lands of Oz and Ev

    Science.gov (United States)

    Matthews, Gareth B.

    2009-01-01

    In this article, the author talks about the philosophical adventures of the characters in L. Frank Baum's Lands of Oz and Ev stories and discusses how such stories can stimulate reflections on philosophically interesting questions. Frank Baum is considered as the first American writer of philosophical fantasy for children for writing "The…

  16. Developing of the EV charging and parking shed of BIPV

    Institute of Scientific and Technical Information of China (English)

    Wu Shaobo; Wei Chuanchuan; Yu Jiang

    2013-01-01

    Building-integrated photovoltaic (BIPV) is an important application way of solar photovoltaic power. The electric vehicle (EV) charging and parking shed of BIPV is the regeneration energy intellectual integration demonstration application system collection of photovoltaic (PV) grid power,PV off-grid power,EV charging and parking shed,and any part of the functions and their combination will be engaged in practical application on demand. The paper describes the PV shed system structure and design in detail with the present of its actual photos. The shed is 50 m long and 5.5 m wide and capable of parking 18 cars. Under the control of system intellectual con-troller,the power produced by PV from sunlight will charge the parking EV car prior to charging the storage bat-tery,charging the storage battery prior to grid power,grid power at last,and charge the EV by utility grid when it is a cloudy or rainy day.

  17. Linear EV model with replicate observations on independent variables

    Institute of Scientific and Technical Information of China (English)

    LIU; Jixue; ZHANG; Sanguo; CHEN; Xiru

    2006-01-01

    This paper studies the linear EV model when replicate observations are made only on independent variables. We construct the estimates of regression coefficients and prove the consistency and asymptotic normality under some proper conditions. Results obtained reveal the difference between the case where the independent and dependent variables are observed repeatedly and simultaneously and the case studied in this article.

  18. Ponjat samogo sebja / Ze'ev Hanin ; interv. Josef Kats

    Index Scriptorium Estoniae

    Hanin, Ze'ev

    2006-01-01

    Lääne tsivilisatsiooni katse seostada tähtsamad maailma poliitikasündmused Iisraeliga ei ole selle riigi süü ega teene, tegemist on euroopa tsivilisatsiooni sügava kriisiga - sellisel seisukohal on hiljuti Tallinna külastanud Bar-Ilani ülikooli õppejõud ja politoloog Ze'ev Hanin

  19. Naistepäev ikka hinnas / Ivar Jung

    Index Scriptorium Estoniae

    Jung, Ivar

    2003-01-01

    Kunstihoone galeriis Ivika Kivi ja Dagmar Kase näituse "ID 2002" taustal 8. III toimunud Reet Varblase organiseeritud seminarist "Naised, ühiskond, ilu ja hügieen". Linnagaleriis lõpetas Meiu Mündi maalinäituse Oksana Titova tantsuetendus. 9. III Pärnus Taave Tuutma kureeritud tegevuskunstipäev

  20. Developing a 500-eV proton beam

    International Nuclear Information System (INIS)

    Tests have been carried out which indicate that H- intensity limitations in lamb-shift polarized ion sources result from large diveregence in the 500-eV H+ ion beam. Intensity limitations due to other effects are not yet measurable

  1. Lanthanum-molybdenum multilayer mirrors for attosecond pulses between 80 and 130 eV

    Energy Technology Data Exchange (ETDEWEB)

    Hofstetter, M; Schultze, M; Guggenmos, A; Gagnon, J; Yakovlev, V S; Krausz, F; Kleineberg, U [Fakultaet fuer Physik, Ludwig-Maximilians-Universitaet Muenchen, Am Coulombwall 1, 85748 Garching (Germany); Aquila, A; Yang, S; Gullikson, E [Center for X-Ray Optics, Lawrence Berkeley National Laboratory, 2-400, 1 Cyclotron Road, Berkeley, CA 94720 (United States); Huth, M; Nickel, B [Center for NanoScience (CeNS), Ludwig-Maximilians-Universitaet Muenchen, Schellingstrasse 4, 80799 Munich (Germany); Goulielmakis, E, E-mail: michael.hofstetter@mpq.mpg.de [Max-Planck-Institut fuer Quantenoptik, Hans-Kopfermann-Strasse 1, 85748 Garching (Germany)

    2011-06-15

    A novel multilayer material system consisting of lanthanum and molybdenum nano-layers for both broadband and highly reflecting multilayer mirrors in the energy range between 80 and 130 eV is presented. The simulation and design of these multilayers were based on an improved set of optical constants, which were recorded by extreme ultraviolet (XUV)/soft-x-ray absorption measurements on freestanding lanthanum nano-films between 30 eV and 1.3 keV. Lanthanum-molybdenum (La/Mo) multilayer mirrors were produced by ion-beam sputtering and characterized through both x-ray and XUV reflectivity measurements. We demonstrate the ability to precisely simulate and realize aperiodic stacks. Their stability against ambient air conditions is demonstrated. Finally, the La/Mo mirrors were used in the generation of single attosecond pulses from high-harmonic cut-off spectra above 100 eV. Isolated 200 attosecond-long pulses were measured by XUV-pump/IR-probe streaking experiments and characterized using frequency-resolved optical gating for complete reconstruction of attosecond bursts (FROG/CRAB) analyses.

  2. Magnetic Alignment Detection Using Existing Charging Facility in Wireless EV Chargers

    Directory of Open Access Journals (Sweden)

    Yabiao Gao

    2016-01-01

    Full Text Available Wireless charging is a promising outlet to promote the electric vehicle (EV industry due to its safe and noncontact manner. Wireless EV chargers require the secondary receiver coil to be well aligned with the primary station for efficient charging, which could require more of the driver’s time and attention when parking a vehicle. Therefore, this paper presents a magnetic alignment system to assist the EV driver during parking. The magnetic alignment approach uses the existing coil and frequency tracking control electronics of wireless chargers to detect the distance between the two coils while using 4 small auxiliary coils for direction and fine adjustment, leading to a cost effective detection method for coil alignment in electric vehicle wireless charging (EVWC. The testing results of a prototype show acceptable measurement correctness and the mean error for ten trials in range detection is within 0.25 cm at three different misalignment conditions (10.5, 15, and 20 cm. The positioning accuracy of coil alignment is within 1.2 cm for three different start positions with the auxiliary coils.

  3. Protective effect of enterovirus-71 (EV71) virus-like particle vaccine against lethal EV71 infection in a neonatal mouse model

    OpenAIRE

    Cao, Lei; MAO, FENGFENG; Pang, Zheng; Yi, Yao; Qiu, Feng; Tian, Ruiguang; MENG, QINGLING; Jia, Zhiyuan; Bi, Shengli

    2015-01-01

    Enterovirus-71 (EV71) is a viral pathogen that causes severe cases of hand, foot and mouth disease (HFMD) among young children, with significant mortality. Effective vaccines against HFMD are urgently required. Several EV71 virus-like particle (VLP) vaccine candidates were found to be protective in the neonatal mouse EV71 challenge model. However, to what extent the VLP vaccine protects susceptible organs against EV71 infection in vivo has remained elusive. In the present study, the comprehen...

  4. A platform for actively loading cargo RNA to elucidate limiting steps in EV-mediated delivery

    OpenAIRE

    Leonard, Joshua N.; Hung, Michelle E.

    2016-01-01

    Extracellular vesicles (EVs) mediate intercellular communication through transfer of RNA and protein between cells. Thus, understanding how cargo molecules are loaded and delivered by EVs is of central importance for elucidating the biological roles of EVs and developing EV-based therapeutics. While some motifs modulating the loading of biomolecular cargo into EVs have been elucidated, the general rules governing cargo loading and delivery remain poorly understood. To investigate how general ...

  5. Neutron Transmission and Capture Measurements and Resonance Parameter Analysis of Neodymium from 1eV to 500 eV

    International Nuclear Information System (INIS)

    Neodymium is a 235U fission product and is important for reactor neutronic calculations. The aim of the present work is to improve upon the existing neutron cross section data of neodymium. Neutron capture and transmission measurements were performed by the time-off-light technique at the Rensselaer Polytechnic Institute LINAC laboratory using metallic neodymium samples. The capture measurements were made at the 25-m flight station with a 16-segment NaI multiplicity detector, and the transmission measurements were performed at 15-m and 25-m flight stations, respectively, with 6Li glass scintillation detectors. After the data were collected and reduced, resonance parameters were determined by combined fitting of the transmission and capture data with the multilevel R-matrix Bayesian code SAMMY. The resonance parameters for all naturally occurring neodymium isotopes were deduced within the energy range of 1 eV to 500 eV. The resulting resonance parameters were used to calculate the capture resonance integrals from this energy. The RPI parameters gave a resonance integral value of 32 ± 1 barns that is approximately 7% lower than that obtained with the ENDF-B/VI parameters. The current measurements significantly reduce the uncertainties on the resonance parameters when compared with previously published parameters

  6. Bounds on sterile neutrino mixing for cosmologically interesting mass range

    CERN Document Server

    Nunokawa, H; Rossi, A; Valle, José W F

    1999-01-01

    This talk summarizes our recent work which studied the impact of resonant neutrino) conversions on supernova physics, under the assumption that the mass of the sterile state is in the few eV -cosmologically significant range.

  7. EV71 virus-like particles produced by co-expression of capsid proteins in yeast cells elicit humoral protective response against EV71 lethal challenge

    OpenAIRE

    Wang, Xiaowen; Xiao, Xiangqian; Zhao, Miao; Wei LIU; Pang, Lin; Sun, Xin; Cen, Shan; Burton B Yang; Huang, Yuming; Sheng, Wang; Zeng, Yi

    2016-01-01

    Background Enterovirus 71 (EV71) is the most common causative pathogens of hand, foot and mouth disease (HFMD) associated with severe neurological complications. There is a great need to develop prophylactic vaccine against EV71 infection. Results EV71 virus-like particle (VLP) was produced in yeast expression system by the co-expression of four EV71 structural proteins VP1–VP4. Immunization with the recombinant VLPs elicited potent anti-EV71 antibody responses in adult mice and anti-VLP sera...

  8. Cascades from nu_E above 1020 eV

    Energy Technology Data Exchange (ETDEWEB)

    Klein, Spencer R.

    2004-12-21

    At very high energies, the Landau-Pomeranchuk-Migdal effect reduces the cross sections for electron bremsstrahlung and photon e{sup +}e{sup -} pair production. The fractional electron energy loss and pair production cross sections drop as the energy increases. In contrast, the cross sections for photonuclear interactions grow with energy. In solids and liquids, at energies above 10{sup 20} eV, photonuclear reactions dominate, and showers that originate as photons or electrons quickly become hadronic showers. These electron-initiated hadronic showers are much shorter (due to the absence of the LPM effect), but wider than purely electromagnetic showers would be. This change in shape alters the spectrum of the electromagnetic and acoustic radiation emitted from the shower. These alterations have important implications for existing and planned searches for radiation from u{sub e} induced showers above 10{sup 20} eV, and some existing limits should be reevaluated.

  9. Archaeology management system based on EV-Globe

    Science.gov (United States)

    Yang, Lin; Lu, Guo-nian; Pei, An-ping; Niu, Yu-gang; Luo, Tao

    2008-10-01

    Traditionally, cultural relics were recorded in a 2D (2 dimensions) method such as paper maps, pictures, multi-media, micro-models and so on. This paper introduces the archaeology management system based on EV-Globe (Earth View-Globe - spatial information service platform on virtual 3D environment) for the cultural relics along the Eastern Route Project (ERP) of South-to-North Water Diversion (SNWD). Integrate the spatial and attribute data of the cultural relics along ERP of SNWD processed by SuperMap deskpro2005 with the relative basic geological data based on the platform of EV-Globe and develop a series of functions based on the SDK (Software Development Kit), and so the relics can be managed visually, at the same time the system may assist the archaeologists and some researchers in managing and studying the cultural relics. Some conception and conceiving of web and mobile version is put forward for next researching.

  10. Open Innovation in EVs: A Case Study of Tesla Motors

    OpenAIRE

    Karamitsios, Achilleas

    2013-01-01

    This study examines the topic of open innovation in EVs. Initially a brief description of the concept of innovation and open innovation is carried out. Moreover, the three processes of open innovation are deployed while the coupled process is described in more detail. Furthermore, a short description is also given for corporate entrepreneurship, alliances, and the U.S. government policy. Also, this report considers Tesla Motors’ partnerships as a case study and it aims to give an insight of h...

  11. Observations from The EV Project in Q3 2013

    Energy Technology Data Exchange (ETDEWEB)

    John Smart

    2013-12-01

    This is a brief report that summarizes results published in numerous other reports. It describes the usage of electric vehicles and charging units in the EV Project over the past 3 months. There is no new data or information provided in this report, only summarizing of information published in other reports (which have all been approved for unlimited distribution publication). This report will be posted to the INL/AVTA website for viewing by the general public.

  12. Intelligent Vehicle Charging Benefits Assessment Using EV Project Data

    Energy Technology Data Exchange (ETDEWEB)

    Letendre, Steven; Gowri, Krishnan; Kintner-Meyer, Michael CW; Pratt, Richard M.

    2013-12-01

    PEVs can represent a significant power resource for the grid. An IVCI with bi-direction V2G capabilities would allow PEVs to provide grid support services and thus generate a source of revenue for PEV owners. The fleet of EV Project vehicles represents a power resource between 30 MW and 90 MW, depending on the power rating of the grid connection (5-15 kW). Aggregation of vehicle capacity would allow PEVs to participate in wholesale reserve capacity markets. One of the key insights from EV Project data is the fact that vehicles are connected to an EVSE much longer than is necessary to deliver a full charge. During these hours when the vehicles are not charging, they can be participating in wholesale power markets providing the high-value services of regulation and spinning reserves. The annual gross revenue potential for providing these services using the fleet of EV Project vehicles is several hundred thousands of dollars to several million dollars annually depending on the power rating of the grid interface, the number of hours providing grid services, and the market being served. On a per vehicle basis, providing grid services can generate several thousands of dollars over the life of the vehicle.

  13. Growth and morphology of 0.80 eV photoemitting indium nitride nanowires

    Energy Technology Data Exchange (ETDEWEB)

    Johnson, M.C.; Lee, C.J.; Bourret-Courchesne, E.D.; Konsek, S.L.; Aloni, S.; Han, W.Q.; Zettl, A.

    2004-08-13

    InN nanowires with high efficiency photoluminescence emission at 0.80 eV are reported for the first time. InN nanowires were synthesized via a vapor solid growth mechanism from high purity indium metal and ammonia. The products consist of only hexagonal wurtzite phase InN. Scanning electron microscopy showed wires with diameters of 50-100nm and having fairly smooth morphologies. High-resolution transmission electron microscopy revealed high quality, single crystal InN nanowires which grew in the <0001> direction. The group-III nitrides have become an extremely important technological material over the past decade. They are commonly used in optoelectronic devices, such as high brightness light-emitting diodes (LEDs) and low wavelength laser diodes (LDs), as well as high power/high frequency electronic devices. Recently InN thin films grown by MOCVD and MBE were found to have a bandgap energy in the range of 0.7-0.9 eV, much lower than the value of {approx}1.9 eV found for InN films grown by sputtering. This large decrease in the direct bandgap transition energy and the ability to form ternary (InGaN) and quaternary (AlInGaN) alloys increases the versatility of group-III nitride optoelectronic devices, ranging from the near IR to the UV. Additionally, InN has some promising transport and electronic properties. It has the smallest effective electron mass of all the group-III nitrides which leads to high mobility and high saturation velocity10 and a large drift velocity at room temperature. As a result of these unique properties, there has been a large increase in interest in InN for potential use in optoelectronic devices, such as LDs and high efficiency solar cells, as well as high frequency/high power electronic devices.

  14. Impact of Fast Charging on Life of EV Batteries; NREL (National Renewable Energy Laboratory)

    Energy Technology Data Exchange (ETDEWEB)

    Neubauer, Jeremy; Wood, Eric; Burton, Evan; Smith, Kandler; Pesaran, Ahmad

    2015-05-03

    Installation of fast charging infrastructure is considered by many as one of potential solutions to increase the utility and range of electric vehicles (EVs). This is expected to reduce the range anxiety of drivers of EVs and thus increase their market penetration. Level 1 and 2 charging in homes and workplaces is expected to contribute to the majority of miles driven by EVs. However, a small percentage of urban driving and most of inter-city driving could be only achieved by a fast-charging network. DC fast charging at 50 kW, 100 kW, 120 kW compared to level 1 (3.3 kW) and level 2 (6.6 kW) results in high-current charging that can adversely impact the life of the battery. In the last couple of years, we have investigated the impact of higher current rates in batteries and potential of higher temperatures and thus lower service life. Using mathematical models, we investigated the temperature increase of batteries due to higher heat generation during fast charge and have found that this could lead to higher temperatures. We compared our models with data from other national laboratories both for fine-tuning and calibration. We found that the incremental temperature rise of batteries during 1C to 3C fast charging may reduce the practical life of the batteries by less than 10% over 10 to 15 years of vehicle ownership. We also found that thermal management of batteries is needed for fast charging to prevent high temperature excursions leading to unsafe conditions.

  15. Underwater Ranging

    Directory of Open Access Journals (Sweden)

    S. P. Gaba

    1984-01-01

    Full Text Available The paper deals with underwater laser ranging system, its principle of operation and maximum depth capability. The sources of external noise and methods to improve signal-to-noise ratio are also discussed.

  16. Dissociative scattering of low-energy SiF{sub 3}{sup +} and SiF{sup +} ions (5-200 eV) on Cu(100) surface

    Energy Technology Data Exchange (ETDEWEB)

    Yamamoto, Hiroyuki; Baba, Yuji; Sasaki, T.A. [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment

    1997-03-01

    Dissociative scattering of molecular SiF{sub 3}{sup +} and SiF{sup +} ions from a Cu(100) single crystal surface has been investigated in the incident energy range from 5 eV to 200 eV with a scattering angle of 77deg. The scattered ion intensity of dissociative ions and parent molecular ions were measured as a function of incident ion energy. The observed data show that onset energies of dissociation for SiF{sub 3}{sup +} and SiF{sup +} ions are 30 eV and 40 eV, respectively. The obtained threshold energies are consistent with a impulsive collision model where the dissociation of incident ion is caused by vibrational excitation during collision. (author)

  17. Refractive indices of zincblende structure {beta}-GaN(001) in the subband-gap region (0.7{endash}3.3 eV)

    Energy Technology Data Exchange (ETDEWEB)

    Vidal, M.A.; Ramirez-Flores, G.; Navarro-Contreras, H.; Lastras-Martinez, A. [Instituto de Investigacion en Communicacion Optica, Universidad Autonoma de San Luis Potosi, Alvaro Obregon 64, San Luis Potosi (Mexico); Powell, R.C.; Greene, J.E. [Materials Science Department, Coordinated Science Laboratory, and Materials Research Laboratory, University of Illinois, Urbana, Illinois 61801 (United States)

    1996-01-01

    Refractive indices {ital n} and absorption coefficients {alpha} of epitaxial metastable zincblende structure {beta}-GaN(001) were determined over the subband-gap energy range between 0.8{endash}3.1 eV from an analysis of optical transmission spectra. {ital n} was found to vary from 2.25 to 0.8 eV (1.55 {mu}m) to 2.50 at 3.1 eV (0.4 {mu}m) with an energy {ital E} (eV) dependence that is well described by a Sellmeir-type dispersion relationship, {ital n}{sup 2}({ital E})=1+148/(38.3{minus}{ital E}{sup 2}). The refractive indices of {beta}-GaN are 3{percent}{endash}4{percent} smaller than previously reported values for hexagonal {alpha}-GaN. {copyright} {ital 1996 American Institute of Physics.}

  18. Potential Analysis of Regulating Power from Electric Vehicle (EV) Integration in Denmark

    DEFF Research Database (Denmark)

    Wu, Qiuwei; Nielsen, Arne Hejde; Østergaard, Jacob;

    2011-01-01

    The potential analysis of having electric vehicles (EVs) provide regulating power has been implemented. The possible regulating power capacity from EVs and the economic return for EV users by providing regulating power are obtained. A spot price based charging schedule scenario has been used to do...... the day-ahead charging schedule for all EVs based on the predicted driving pattern. On top of the obtained charging schedule, the predicted EV availability and the charging schedule are used to calculate the possible regulating power capacity from EVs for both up regulating power and down regulating power...

  19. Recombination in the evolution of enterovirus C species sub-group that contains types CVA-21, CVA-24, EV-C95, EV-C96 and EV-C99.

    Directory of Open Access Journals (Sweden)

    Teemu Smura

    Full Text Available Genetic recombination is considered to be a very frequent phenomenon among enteroviruses (Family Picornaviridae, Genus Enterovirus. However, the recombination patterns may differ between enterovirus species and between types within species. Enterovirus C (EV-C species contains 21 types. In the capsid coding P1 region, the types of EV-C species cluster further into three sub-groups (designated here as A-C. In this study, the recombination pattern of EV-C species sub-group B that contains types CVA-21, CVA-24, EV-C95, EV-C96 and EV-C99 was determined using partial 5'UTR and VP1 sequences of enterovirus strains isolated during poliovirus surveillance and previously published complete genome sequences. Several inter-typic recombination events were detected. Furthermore, the analyses suggested that inter-typic recombination events have occurred mainly within the distinct sub-groups of EV-C species. Only sporadic recombination events between EV-C species sub-group B and other EV-C sub-groups were detected. In addition, strict recombination barriers were inferred for CVA-21 genotype C and CVA-24 variant strains. These results suggest that the frequency of inter-typic recombinations, even within species, may depend on the phylogenetic position of the given viruses.

  20. Transmittance and optical constants of Eu films from 8.3 to 1400 eV

    International Nuclear Information System (INIS)

    The optical constants of Eu films were obtained in the 8.3-1400 eV range from transmittance measurements performed at room temperature. Thin films of Eu were deposited by evaporation in ultrahigh vacuum conditions and their transmittance was measured in situ. Eu films were deposited onto grids coated with a thin C support film. The refractive index n of Eu was calculated using the Kramers-Kronig analysis. Data were extrapolated both on the high- and low-energy sides by using experimental and calculated extinction coefficient values available in the literature. Eu, similar to other lanthanides, has a low-absorption band just below the O2,3 edge onset; the lowest absorption was measured at about 16.7 eV. Therefore, Eu is a promising material for filters and multilayer coatings in the energy range below the O2,3 edge in which materials typically have a strong absorption. The consistency of the composite optical constants was tested with the f and inertial sum rules and found to be good

  1. [Establishment of EV71 animal models with 2-week-old BALB/c mice].

    Science.gov (United States)

    Wang, Hui-Qiang; Jiang, Jian-Dong; Li, Yu-Huan

    2013-03-01

    Animal model is very important for anti-EV71 (enterovirus 71) drug and vaccine development. 1-day-old suckling EV71 mouse model is the main in vivo model used in China. 1-day-old suckling EV71 mouse is too small to perform antiviral experiment. And the route of administration and dosage capacity are also restricted. A strong virulence EV71 virus strain was selected after screening from five EV71 strains with 1-day-old suckling mice. A mouse-adapted EV71 strain with increased virulence in 12-day-old suckling mice, EV71-M5, was generated after five serial passages of the parental EV71 strain in mice. Virus titers of EV71 infected mice heart, liver, spleen, lung, kidney, small intestine, brain and muscle tissue were determined by cytopathic effect (CPE) assay. The virus used in this model is the first isolated EV71 strain in China. And 2-week-old suckling mice were used in this model. This is a supplement for the EV71 animal model in China. Establishment of this EV71 model will provide an attractive platform for anti-EV71 vaccine and drug development.

  2. Temperature and salinity profile data from globally distributed Argo profiling floats for the week of 2009-12-24 for the Global Argo Data Repository, date ranged from 2002-02-15 to 2009-12-30 (NODC Accession 0060860)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The U.S. National Oceanographic Data Center (NODC) operates the Global Argo Data Repository (GADR) as the long-term archive for the International Global Argo...

  3. EV71 Infection and Innate Antiviral Innate Immunity%EV71的感染和抗病毒天然免疫应答

    Institute of Scientific and Technical Information of China (English)

    谢广成; 段招军

    2016-01-01

    EV71是儿童手足口病的主要病原体,部分感染儿童会出现疱疹性咽峡炎以及严重的肺水肿和/或脑干脑炎.近几年,EV71感染引起的疾病机制研究取得了诸多进展.本文针对目前EV71的敏感细胞、EV71感染激活的信号途径以及EV71感染活化的天然免疫应答或免疫逃逸机制研究进行综述,旨在为EV71抗病毒药物研制和免疫致病机理的研究提供思路.

  4. The approved pediatric drug suramin identified as a clinical candidate for the treatment of EV71 infection-suramin inhibits EV71 infection in vitro and in vivo.

    Science.gov (United States)

    Ren, Peijun; Zou, Gang; Bailly, Benjamin; Xu, Shanshan; Zeng, Mei; Chen, Xinsheng; Shen, Liang; Zhang, Ying; Guillon, Patrice; Arenzana-Seisdedos, Fernando; Buchy, Philippe; Li, Jian; von Itzstein, Mark; Li, Qihan; Altmeyer, Ralf

    2014-09-01

    Enterovirus 71 (EV71) causes severe central nervous system infections, leading to cardiopulmonary complications and death in young children. There is an urgent unmet medical need for new pharmaceutical agents to control EV71 infections. Using a multidisciplinary approach, we found that the approved pediatric antiparasitic drug suramin blocked EV71 infectivity by a novel mechanism of action that involves binding of the naphtalentrisulonic acid group of suramin to the viral capsid. Moreover, we demonstrate that when suramin is used in vivo at doses equivalent to or lower than the highest dose already used in humans, it significantly decreased mortality in mice challenged with a lethal dose of EV71 and peak viral load in adult rhesus monkeys. Thus, suramin inhibits EV71 infection by neutralizing virus particles prior to cell attachment. Consequently, these findings identify suramin as a clinical candidate for further development as a therapeutic or prophylactic treatment for severe EV71 infection.

  5. Si-Ge-Sn alloys with 1.0 eV gap for CPV multijunction solar cells

    Energy Technology Data Exchange (ETDEWEB)

    Roucka, Radek, E-mail: radek@translucentinc.com; Clark, Andrew [Translucent Inc., Palo Alto, CA, 94303 (United States); Landini, Barbara [Sumika Electronic Materials Inc., Phoenix, AZ, 85034 (United States)

    2015-09-28

    Si-Ge-Sn ternary group IV alloys offer an alternative to currently used 1.0 eV gap materials utilized in multijunction solar cells. The advantage of Si-Ge-Sn is the ability to vary both the bandgap and lattice parameter independently. We present current development in fabrication of Si-Ge-Sn alloys with gaps in the 1.0 eV range. Produced material exhibits excellent structural properties, which allow for integration with existing III-V photovoltaic cell concepts. Time dependent room temperature photoluminescence data demonstrate that these materials have long carrier lifetimes. Absorption tunable by compositional changes is observed. As a prototype device set utilizing the 1 eV Si-Ge-Sn junction, single junction Si-Ge-Sn device and triple junction device with Si-Ge-Sn subcell have been fabricated. The resulting I-V and external quantum efficiency data show that the Si-Ge-Sn junction is fully functional and the performance is comparable to other 1.0 eV gap materials currently used.

  6. Secondary Use of PHEV and EV Batteries: Opportunities & Challenges (Presentation)

    Energy Technology Data Exchange (ETDEWEB)

    Neubauer, J.; Pesaran, A.; Howell, D.

    2010-05-01

    NREL and partners will investigate the reuse of retired lithium ion batteries for plug-in hybrid, hybrid, and electric vehicles in order to reduce vehicle costs and emissions and curb our dependence on foreign oil. A workshop to solicit industry feedback on the process is planned. Analyses will be conducted, and aged batteries will be tested in two or three suitable second-use applications. The project is considering whether retired PHEV/EV batteries have value for other applications; if so, what are the barriers and how can they be overcome?

  7. Optimization of unipolar magnetic couplers for EV wireless power chargers

    Science.gov (United States)

    Zeng, H.; Liu, Z. Z.; Chen, H. X.; Zhou, B.; Hei, T.

    2016-08-01

    In order to improve the coupling coefficient of EV wireless power chargers, it's important to optimize the magnetic couplers. To improve the coupling coefficient, the relationship between coupling coefficient and efficiency is derived, and the expression of coupling coefficient based on magnetic circuit is deduced, which provide the basis for optimizing the couplers. By 3D FEM simulation, the optimal core structure and coils are designed for unipolar circular couplers. Experiments are designed to verify the correctness of the optimization results, and compared with previous coupler, the transmission efficiency is improved and weight is reduced.

  8. "Iga päev..." : [luuletused] / Doris Kareva

    Index Scriptorium Estoniae

    Kareva, Doris, 1958-

    2001-01-01

    Tekst eesti ja inglise k. D. Kareva lühibiograafia eesti ja inglise k. lk. 175. Sisu: "Iga päev..." = "Every day..." ; "Ma nägin unes - Saatan kõneles..." = "I dream that I heard Satan speak..." ; "Viib sünnieelsest unest surmaunne..." = "Rainbow-coloured confusion bears us..." ; "Vaadeldes vikerkaarlevat maailma..." = "Viewing the rainbowing world..." ; "Ei jõua kirjutada puhtandit..." = "No time to write the final draft..." ; "Põletatud luuletused..." = ""Burnt poems..." ; Fraktalia ; Müsteerium 1-5 = Enigma 1-5 ; "Jumal juhtub..." = "God happens..." ; Moira 1-7 = Wishing well 1-7 ; Concerto strumenti e voce

  9. Estimation in partial linear EV models with replicated observations

    Institute of Scientific and Technical Information of China (English)

    CUI Hengjian

    2004-01-01

    The aim of this work is to construct the parameter estimators in the partial linear errors-in-variables (EV) models and explore their asymptotic properties. Unlike other related References, the assumption of known error covariance matrix is removed when the sample can be repeatedly drawn at each designed point from the model. The estimators of interested regression parameters, and the model error variance, as well as the nonparametric function, are constructed. Under some regular conditions, all of the estimators prove strongly consistent. Meanwhile, the asymptotic normality for the estimator of regression parameter is also presented. A simulation study is reported to illustrate our asymptotic results.

  10. Protective effect of enterovirus‑71 (EV71) virus‑like particle vaccine against lethal EV71 infection in a neonatal mouse model.

    Science.gov (United States)

    Cao, Lei; Mao, Fengfeng; Pang, Zheng; Yi, Yao; Qiu, Feng; Tian, Ruiguang; Meng, Qingling; Jia, Zhiyuan; Bi, Shengli

    2015-08-01

    Enterovirus-71 (EV71) is a viral pathogen that causes severe cases of hand, foot and mouth disease (HFMD) among young children, with significant mortality. Effective vaccines against HFMD are urgently required. Several EV71 virus-like particle (VLP) vaccine candidates were found to be protective in the neonatal mouse EV71 challenge model. However, to what extent the VLP vaccine protects susceptible organs against EV71 infection in vivo has remained elusive. In the present study, the comprehensive immunogenicity of a potential EV71 vaccine candidate based on VLPs was evaluated in a neonatal mouse model. Despite lower levels of neutralizing antibodies to EV71 in the sera of VLP-immunized mice compared with those in mice vaccinated with inactivated EV71, the VLP-based vaccine was shown to be able to induce immunoglobulin (Ig)G and IgA memory-associated cellular immune responses to EV71. Of note, the EV71 VLP vaccine candidate was capable of inhibiting viral proliferation in cardiac muscle, skeletal muscle, lung and intestine of immunized mice and provided effective protection against the pathological damage caused by viral attack. In particular, the VLP vaccine was able to inhibit the transportation of EV71 from the central nervous system to the muscle tissue and greatly protected muscle tissue from infection, along with recovery from the viral infection. This led to nearly 100% immunoprotective efficacy, enabling neonatal mice delivered by VLP-immunized female adult mice to survive and grow with good health. The present study provided valuable additional knowledge of the specific protective efficacy of the EV71 VLP vaccine in vivo, which also indicated that it is a promising potential candidate for being developed into an EV71 vaccine.

  11. Electron Landau damping in toroidal plasma with Solov'ev equilibrium

    Science.gov (United States)

    Grishanov, N. I.; Azarenkov, N. A.

    2013-12-01

    The contribution of untrapped and two groups of trapped particles to the longitudinal (with respect to the magnetic field) elements of the dielectric susceptibility is determined by solving the drift-kinetic equations for such particles in axisymmetric tokamaks with Solov'ev equilibrium. The obtained dielectric characteristics are applicable for studying linear wave processes in the frequency range of Alfvén and fast magnetosonic waves in small- and large-aspect-ratio tokamaks with circular, elliptical, and D-shaped cross sections of magnetic surfaces. The high-frequency power absorbed in plasma via electron Landau damping is estimated by summing up terms containing the imaginary parts of both diagonal and non-diagonal elements of the longitudinal susceptibility. The imaginary part of the longitudinal susceptibility is calculated numerically for spherical tokamaks in a wide range of wave frequencies and magnetic surface radii.

  12. A new treatment for neurogenic inflammation caused by EV71 with CR2-targeted complement inhibitor

    OpenAIRE

    Qiu Shaofu; Liu Nan; Jia Leili; Yang Guang; Su Wenli; Li Jing; Song Lixue; Yang Chaojie; Wang Jian; Zhang Chuanfu; Wang Zhongqiang; Qiao Fei; Tomlinson Stephen; Atkinson Carl; Sun Yansong

    2012-01-01

    Abstract Background Enterovirus 71 (EV71), one of the most important neurotropic EVs, has caused death and long-term neurological sequelae in hundreds of thousands of young children in the Asia-Pacific region in the past decade. The neurological diseases are attributed to infection by EV71 inducing an extensive peripheral and central nervous system (CNS) inflammatory response with abnormal cytokine production and lymphocyte depletion induced by EV71 infection. In the absence of specific antiv...

  13. Recent Progress towards Novel EV71 Anti-Therapeutics and Vaccines

    OpenAIRE

    Qingyong Ng; Fang He; Jimmy Kwang

    2015-01-01

    Enterovirus 71 (EV71) is a group of viruses that belongs to the Picornaviridae family, which also includes viruses such as polioviruses. EV71, together with coxsackieviruses, is widely known for its association with Hand Foot Mouth Disease (HFMD), which generally affects children age five and below. Besides HFMD, EV71 can also trigger more severe and life-threatening neurological conditions such as encephalitis. Considering the lack of a vaccine and antiviral drug against EV71, together with ...

  14. 重症手足口病EV71感染护理体会%Nursing Experience of HFMD Children with Severe EV71 Infection

    Institute of Scientific and Technical Information of China (English)

    金利萍; 房彤; 芦玮玮

    2009-01-01

    目的:总结重症EV71感染患儿的护理经验.方法:时100多例重症EV71感染患儿的临床表现、救治措施及护理方法进行分析.结果:总结出重症手足口病EV71感染患儿各项护理要点.结论:重症EV71感染患儿的救治工作在配合护理措施后提高救治成功率.

  15. How to deal with PCR composition problem at $E_0 \\gtrsim 10^{17}$ eV

    CERN Document Server

    Galkin, V I; Bakhromzod, R; Mukumov, A

    2015-01-01

    Basic ideas of muon tracker technique for the solution of primary cosmic ray (PCR) composition problem in the energy range $10^{17}-10^{18}$ eV are presented. The approach uses MC simulation data made with CORSIKA6.990 for "Pamir-XXI" site conditions. Similar technology can certainly be developed for other observation levels and interaction models. One can probably extend it to much higher primary energies.

  16. The attractivity of Mendrisio as industrial area for EVs

    Energy Technology Data Exchange (ETDEWEB)

    Piffaretti, M. [InfoVEL, Mendrisio (Switzerland)

    2000-07-01

    Located in the Italian speaking region of Switzerland, Mendrisio is in the Canton Ticino. The city of 300,000 people is served by two international airports, the Lugano-Agno 15 km away and the Milano-Malpensa 60 km away. Car manufacturers introduced their different alternative technologies in the area through the electric vehicle (EV) - Pilot and Demonstration Project. The country is neutral, and does not have protectionist policies in the area of car manufacturing, since the country does not have a national car manufacturer. The decision-makers and the population are open to new technologies, as demonstrated by the fact that 335 EVs are already in operation in the region. Infrastructure, in the form of charging stations, is already in place, as are tax exemptions and other financial incentives. Highly skilled workers, fluent in many languages abound and are supported by high schools and public research centers. The author briefly described a few selected initiatives that were implemented in the last few years.

  17. EV71病毒核酸快速检测方法的比较%Comparison of Different Molecular Assays for the Rapid Detection of Enterovirus 71(EV71)

    Institute of Scientific and Technical Information of China (English)

    卫海燕; 黄学勇; 许玉玲; 马宏; 陈豪敏; 许汴利

    2012-01-01

    Molecular detection of enterovirus (EV)71 RNA based on PCR methods is a quick and sensitive approach. At present, different PCR-based methods for EV71 RNA detection are available, but comparisons of results obtained using different approaches are limited. This study is to compare the analytical sensitivity and specificity of different real-time reverse transcription-polymerase chain reaction (rRT-PCR) and conventional reverse transcription-polymerase chain reaction (cRT-PCR) assays for enterovirus and EV71 detection, Altogether, three rRT-PCR assays and one cRT-PCR assay targeting the 5'UTR gene for universal detection of enterovirus; two rRT-PCR assays andone cRT-PCR assay targeting the VP1 gene for specific detection of EV 71 were examined. All assays showed good specificity. The detection sensitivity ranged from 8. 19 ×10 to 8. 19 ×105 copy equivalents. In general, rRT-PCR assays were more sensitive than cRT-PCR assays. All rRT-PCR assays showed 100% sensitivity for clinical specimens.%PCR方法检测肠道病毒71型(EV71)的分子诊断技术十分快速敏感.目前已有多篇文献报道了不同的检测EV71的PCR方法,但对不同方法检测结果的比较还少有报道.本研究将检测肠道病毒通用5′UTR基因的3种定量PCR(rRT-PCR)方法和1种普通PCR(cRT-PCR)方法和特异性检测EV71的2种rRT-PCR和1种cRT-PCR方法进行特异性和敏感性比较评估.所有试验方法都有较好的特异性,无交叉反应.核酸最低检测限值为从8.19× 101~8.19×105个拷贝,rRT-PCR比cRT-PCR更敏感.所有的rRT-PCR方法检测50份临床标本时都较敏感.

  18. Measurements of differential cross sections with electrons of intermediate energy (300-1000 eV) scattered by atom and molecule

    International Nuclear Information System (INIS)

    Differential Elastic Cross Sections for electrons scattered by osub(2) and Ar in the angular range 5 sup(0)- 140 sup(0) were measured in the energy range between 300 and 1000 eV. The Relative Flow Technique proposed by SRIVASTAVA et alii (1975) was used. Absolute Differential Elastic Cross Section data from DuBOIS and RUDD (1976) for Nsub(2) were stablished as a secondary standard. Our obtained results for Ar at 400, 800 and 1000 eV were compared against experimental and theoretical results available in the literature. For molecular Oxygen at 300, 400, 800 and 1000 eV our experimental data were compared with values from other authors and also theoretical values from Independent Atom Model including Multiple Intramolecular Scattering. Results for Ar at 1000 eV in the angular range between 60 sup(0) and 140 sup(0) and for osub(2) at 800 and 100 eV, between 5 sup(0) and 120 sup(0), were reported for the first time. (author)

  19. Why is the Dark Axion Mass $10^{-22}$ eV?

    CERN Document Server

    Chiueh, Tzihong

    2014-01-01

    Scalar field dark matter likely is able to solve all small-scale cosmology problems facing the cold dark matter (CDM), and has become an emerging contender to challenge the CDM. It however requires a particle mass $\\sim 1 - 2 \\times10^{-22}$eV. We find such an extremely small particle mass can naturally arise from a non-QCD axion mechanism, under fairly general assumptions that a few species of self-interacting light particles of comparable masses and a massless gauge boson decouple from the bright sector since the photon temperature exceeds 200 GeV, and the axion is the dominant dark matter. These assumptions also set the axion decay constant scale to several $\\times 10^{16}$ GeV. Given the above axion mass range, we further pin down the dark-sector particles to consist of only one species of fermion and anti-fermion, likely right-handed neutrinos. With a mass around $92-128$ eV, the dark-sector particles may constitute a minority population of dark matter. If the gauge boson lives on SU(2), a dilute instant...

  20. RASSF4 promotes EV71 replication to accelerate the inhibition of the phosphorylation of AKT.

    Science.gov (United States)

    Zhang, Fengfeng; Liu, Yongjuan; Chen, Xiong; Dong, Lanlan; Zhou, Bingfei; Cheng, Qingqing; Han, Song; Liu, Zhongchun; Peng, Biwen; He, Xiaohua; Liu, Wanhong

    2015-03-20

    Enterovirus 71 (EV71) is a neurotropic virus that causes hand, foot and mouth disease (HFMD), occasionally leading to death. As a member of the RAS association domain family (RASSFs), RASSF4 plays important roles in cell death, tumor development and signal transduction. However, little is known about the relationship between RASSF4 and EV71. Our study reveals for the first time that RASSF4 promotes EV71 replication and then accelerates AKT phosphorylation inhibition in EV71-infected 293T cells, suggesting that RASSF4 may be a potential new target for designing therapeutic measures to prevent and control EV71 infection.

  1. Analysis on influencing factors of EV charging station planning based on AHP

    Science.gov (United States)

    Yan, F.; Ma, X. F.

    2016-08-01

    As a new means of transport, electric vehicle (EV) is of great significance to alleviate the energy crisis. EV charging station planning has a far-reaching significance for the development of EV industry. This paper analyzes the impact factors of EV charging station planning, and then uses the analytic hierarchy process (AHP) to carry on the further analysis to the influencing factors, finally it gets the weight of each influence factor, and provides the basis for the evaluation scheme of the planning of charging stations for EV.

  2. On the maximal terms of succesive Gelfond-Leont’ev-Salagen and Gelfond- Leont’ev-Ruscheweyh derivatives of a function analytic in the unit disc

    Directory of Open Access Journals (Sweden)

    M. M. Sheremeta

    2012-03-01

    Full Text Available For a function analytic in the unit disc the concepts of Gelfond-Leont'ev-Salagen and Gelfond-Leont'ev-Ruscheweyh derivatives of n-th order are introduced and the asymptotic behaviour of the maximal terms of their power development as n→+∞ is investigated.

  3. Delivery of human EV71 receptors by adeno-associated virus increases EV71 infection-induced local inflammation in adult mice.

    Science.gov (United States)

    Hsiao, Hung-Bo; Chou, Ai-Hsiang; Lin, Su-I; Lien, Shu-Pei; Liu, Chia-Chyi; Chong, Pele; Chen, Chih-Yeh; Tao, Mi-Hua; Liu, Shih-Jen

    2014-01-01

    Enterovirus71 (EV71) is now recognized as an emerging neurotropic virus in Asia and one major causative agent of hand-foot-mouth diseases (HFMD). However potential animal models for vaccine development are limited to young mice. In this study, we used an adeno-associated virus (AAV) vector to introduce the human EV71 receptors P-selectin glycoprotein ligand-1 (hPSGL1) or a scavenger receptor class-B member-2 (hSCARB2) into adult ICR mice to change their susceptibility to EV71 infection. Mice were administered AAV-hSCARB2 or AAV-hPSGL1 through intravenous and oral routes. After three weeks, expression of human SCARB2 and PSGL1 was detected in various organs. After infection with EV71, we found that the EV71 viral load in AAV-hSCARB2- or AAV-hPSGL1-transduced mice was higher than that of the control mice in both the brain and intestines. The presence of EV71 viral particles in tissues was confirmed using immunohistochemistry analysis. Moreover, inflammatory cytokines were induced in the brain and intestines of AAV-hSCARB2- or AAV-hPSGL1-transduced mice after EV71 infection but not in wild-type mice. However, neurological disease was not observed in these animals. Taken together, we successfully infected adult mice with live EV71 and induced local inflammation using an AAV delivery system.

  4. Detection of RNA of EV71 in hospital sewage%医院污水中EV71病毒核酸的检验

    Institute of Scientific and Technical Information of China (English)

    王华洪; 白志永

    2009-01-01

    目的 研究医院污水EV71病毒核酸的检测方法,为手足口病控制提供依据.方法 用栽阳电荷的硅胶滤材吸附浓集污水中的EV71病毒,然后用RT-PCR和实时荧光PCR技术检测EV71病毒.结果 建立的栽阳电荷硅胶浓集方法能有效浓集医院污水中的EV71病毒,通过对6家医院的医院污水检测有2家检出EV71病毒核酸,所有检出EV71核酸的医院污水余氯都不符合国家卫生标准.结论 医院污水中含有EV71病毒核酸,提示其为环境中EV71病毒的重要污染源.因此需要加强医院污水消毒的监督检查.

  5. EV71 infection correlates with viral IgG preexisting at pharyngolaryngeal mucosa in children

    Institute of Scientific and Technical Information of China (English)

    Jingchang; Xue; Yaoming; Li; Xiaoyi; Xu; Jie; Yu; Hu; Yan; Huimin; Yan

    2015-01-01

    Enterovirus 71(EV71) infection causes severe central nervous system damage, particularly for children under the age of 5 years old, which remains a major public health burden worldwide. Clinical data released that children may be repeatedly infected by different members in enterovirus and get even worsen. Mucosa, especially epithelium of alimentary canal, was considered the primary site of EV71 infection. It has been elusive whether the preexsiting viral antibody in mucosa plays a role in EV71 infection. To answer this question, we respectively measured viral antibody response and EV71 RNA copy number of one hundred throat swab specimens from clinically confirmed EV71-infected children. The results released that low-level of mucosal Ig G antibody against EV71 broadly existed in young population. More importantly, it further elucidated that the children with mucosal preexsiting EV71 Ig G were prone to be infected, which suggested a former viral Ig G mediated enhancement of viral infection in vivo.

  6. Impact Study of Electric Vehicle (EV) Integration on Low Voltage (LV) Grids

    DEFF Research Database (Denmark)

    Wu, Qiuwei; Cha, Seung-Tae; Nielsen, Arne Hejde;

    2012-01-01

    Large scale deployment of electric vehicles (EVs) has become a very interesting option because it can both reduce the greenhouse gas (GHG) emission from the transport sector and facilitate the integration of more renewable energy resources (RES) by providing the flexibility of EV charging demands....... Although the EV grid integration is promising, the impact of the EV grid integration has to be investigated in order to identify the bottlenecks of power systems for the EV grid integration and assess different charging scenarios. This paper is focused on the impact of EV grid integration on low voltage...... (LV) grids. The work consists of modeling a typical LV grid, EV charging schedule managment, and impact study of different charging scenarios on LV grid. The modelling work of the LV grid is done using the data from the Bornholm power system. The topology data of the LV grid are used to develop...

  7. Recent Progress towards Novel EV71 Anti-Therapeutics and Vaccines.

    Science.gov (United States)

    Ng, Qingyong; He, Fang; Kwang, Jimmy

    2015-12-01

    Enterovirus 71 (EV71) is a group of viruses that belongs to the Picornaviridae family, which also includes viruses such as polioviruses. EV71, together with coxsackieviruses, is widely known for its association with Hand Foot Mouth Disease (HFMD), which generally affects children age five and below. Besides HFMD, EV71 can also trigger more severe and life-threatening neurological conditions such as encephalitis. Considering the lack of a vaccine and antiviral drug against EV71, together with the increasing spread of these viruses, the development of such drugs and vaccines becomes the top priority in protecting our younger generations. This article, hence, reviews some of the recent progress in the formulations of anti-therapeutics and vaccine generation for EV71, covering (i) inactivated vaccines; (ii) baculovirus-expressed vaccines against EV71; (iii) human intravenous immunoglobulin (IVIg) treatment; and (iv) the use of monoclonal antibody therapy as a prevention and treatment for EV71 infections.

  8. EV71-infected CD14(+) cells modulate the immune activity of T lymphocytes in rhesus monkeys.

    Science.gov (United States)

    Wang, Jingjing; Pu, Jing; Huang, Hongtai; Zhang, Ying; Liu, Longding; Yang, Erxia; Zhou, Xiaofang; Ma, Na; Zhao, Hongling; Wang, Lichun; Xie, Zhenfeng; Tang, Donghong; Li, Qihan

    2013-07-01

    Preliminary studies of the major pathogen enterovirus 71 (EV71), a member of the Picornaviridae family, have suggested that EV71 may be a major cause of fatal hand, foot and mouth disease cases. Currently, the role of the pathological changes induced by EV71 infection in the immunopathogenic response remains unclear. Our study focused on the interaction between this virus and immunocytes and indicated that this virus has the ability to replicate in CD14(+) cells. Furthermore, these EV71-infected CD14(+) cells have the capacity to stimulate the proliferation of T cells and to enhance the release of certain functional cytokines. An adaptive immune response induced by the back-transfusion of EV71-infected CD14(+) cells was observed in donor neonatal rhesus monkeys. Based on these observations, the proposed hypothesis is that CD14(+) cells infected by the EV71 virus might modulate the anti-EV71 adaptive immune response by inducing simultaneous T-cell activation.

  9. LARGE-SCALE DISTRIBUTION OF ARRIVAL DIRECTIONS OF COSMIC RAYS DETECTED ABOVE 10{sup 18} eV AT THE PIERRE AUGER OBSERVATORY

    Energy Technology Data Exchange (ETDEWEB)

    Abreu, P.; Andringa, S. [LIP and Instituto Superior Tecnico, Technical University of Lisbon (Portugal); Aglietta, M. [Istituto di Fisica dello Spazio Interplanetario (INAF), Universita di Torino and Sezione INFN, Torino (Italy); Ahlers, M. [University of Wisconsin, Madison, WI (United States); Ahn, E. J. [Fermilab, Batavia, IL (United States); Albuquerque, I. F. M. [Instituto de Fisica, Universidade de Sao Paulo, Sao Paulo, SP (Brazil); Allard, D. [Laboratoire AstroParticule et Cosmologie (APC), Universite Paris 7, CNRS-IN2P3, Paris (France); Allekotte, I. [Centro Atomico Bariloche and Instituto Balseiro (CNEA-UNCuyo-CONICET), San Carlos de Bariloche (Argentina); Allen, J. [New York University, New York, NY (United States); Allison, P. [Ohio State University, Columbus, OH (United States); Almela, A. [Facultad Regional Buenos Aires, Universidad Tecnologica Nacional, Buenos Aires (Argentina); Alvarez Castillo, J. [Universidad Nacional Autonoma de Mexico, Mexico, D. F. (Mexico); Alvarez-Muniz, J. [Universidad de Santiago de Compostela (Spain); Alves Batista, R. [IFGW, Universidade Estadual de Campinas, Campinas, SP (Brazil); Ambrosio, M.; Aramo, C. [Universita di Napoli ' Federico II' and Sezione INFN, Napoli (Italy); Aminaei, A. [IMAPP, Radboud University Nijmegen (Netherlands); Anchordoqui, L. [University of Wisconsin, Milwaukee, WI (United States); Antici' c, T. [Rudjer Boskovi' c Institute, 10000 Zagreb (Croatia); Arganda, E. [IFLP, Universidad Nacional de La Plata and CONICET, La Plata (Argentina); Collaboration: Pierre Auger Collaboration; and others

    2012-12-15

    A thorough search for large-scale anisotropies in the distribution of arrival directions of cosmic rays detected above 10{sup 18} eV at the Pierre Auger Observatory is presented. This search is performed as a function of both declination and right ascension in several energy ranges above 10{sup 18} eV, and reported in terms of dipolar and quadrupolar coefficients. Within the systematic uncertainties, no significant deviation from isotropy is revealed. Assuming that any cosmic-ray anisotropy is dominated by dipole and quadrupole moments in this energy range, upper limits on their amplitudes are derived. These upper limits allow us to test the origin of cosmic rays above 10{sup 18} eV from stationary Galactic sources densely distributed in the Galactic disk and predominantly emitting light particles in all directions.

  10. BEST sensitivity to O(1) eV sterile neutrino

    CERN Document Server

    Barinov, Vladislav; Gorbunov, Dmitry; Ibragimova, Tatiana

    2016-01-01

    Numerous anomalous results in neutrino oscillation experiments can be attributed to interference of ~1 eV sterile neutrino. The specially designed to fully explore the Gallium anomaly Baksan Experiment on Sterile Transitions (BEST) starts next year. We investigate the sensitivity of BEST in searches for sterile neutrino mixed with electron neutrino. Then, performing the combined analysis of all the Gallium experiments (SAGE, GALLEX, BEST) we find the regions in model parameter space (sterile neutrino mass and mixing angle), which will be excluded if BEST agrees with no sterile neutrino hypothesis. For the opposite case, if BEST observes the signal as it follows from the sterile neutrino explanation of the Gallium (SAGE and GALLEX) anomaly, we show how BEST will improve upon the present estimates of the model parameters.

  11. Approximation of Vorob'ev expectation for random closed sets

    CERN Document Server

    Heinrich, Philippe; Tran, Viet Chi

    2010-01-01

    Random sets appear in many applications, in particular in image analysis. The issue of a "mean shape" often arises since there is no canonical definition. In this paper, we propose a consistent and ready to use estimator for the Vorob'ev expectation of a random set $X$. It is a kind of mean closely linked to quantile-like quantities and built from independent copies of $X$ with spatial discretization. The convergence is established through the Strong Law of Large Numbers of Kovyazin. The control of discretization errors is handled with a mild regularity assumption on the boundary of $X$: a not too large 'box counting' dimension. Some examples, including Boolean models, are studied.

  12. Construction Project Forecasting "Practical Use of EV Metrics"

    Institute of Scientific and Technical Information of China (English)

    Reda Abbas Sabry

    2014-01-01

    During this professional research--Construction Project Forecasting (Practical Use of EV Metrics), which criticize earned value management as a most distinguished methodology for forecasting the project expected end dates and expecting budget at completion, the field for the research is construction field and specially the projects which content different phases without repetitive tasks. Forecasting for construction project is a complicated process need more than applying one equation only. As assuming that, project performance during finishing stage will be similar to project performance during concrete stage is totally wrong. The case study techniques have been used to prove an important idea and also to implement a suggested protocol which actually implemented and tested and it should be considered as a research finding. The project used in this case study is "Hurgadah Intemational Airport--New Terminal Building", while executing this complex construction projects with different stages the forecasting for the project end date and final end budget were completely not realistic. The above leads to questioning the next: "Is it true that using the earned value indexes for forecasting construction projects end date and final budget is the right way? And if not, what is the right process that should be used in order to reach acceptable forecasting method?" We implement the EV measurements by the normal technique and also implement in the same month the suggested protocol for forecasting, comparing the results proof the effectiveness of the suggested protocol. The findings prove that, the construction projects need special treatment when use the EVM for forecasting. The earned value indexes created to serve the projects which have repeated tasks or can say which got one stage only, like information technology (IT) projects as those projects depending on manpower productivity and also based on few different qualifications. On such type of projects

  13. Phenotypic and genotypic characteristics of novel mouse cell line (NIH/3T3-adapted human enterovirus 71 strains (EV71:TLLm and EV71:TLLmv.

    Directory of Open Access Journals (Sweden)

    Carla Bianca Luena Victorio

    Full Text Available Since its identification in 1969, Enterovirus 71 (EV71 has been causing periodic outbreaks of infection in children worldwide and most prominently in the Asia-Pacific Region. Understanding the pathogenesis of Enterovirus 71 (EV71 is hampered by the virus's inability to infect small animals and replicate in their derived in vitro cultured cells. This manuscript describes the phenotypic and genotypic characteristics of two selected EV71 strains (EV71:TLLm and EV71:TLLmv, which have been adapted to replicate in mouse-derived NIH/3T3 cells, in contrast to the original parental virus which is only able to replicate in primate cell lines. The EV71:TLLm strain exhibited productive infection in all primate and rodent cell lines tested, while EV71:TLLmv exhibited greater preference for mouse cell lines. EV71:TLLmv displayed higher degree of adaptation and temperature adaptability in NIH/3T3 cells than in Vero cells, suggesting much higher fitness in NIH/3T3 cells. In comparison with the parental EV71:BS strain, the adapted strains accumulated multiple adaptive mutations in the genome resulting in amino acid substitutions, most notably in the capsid-encoding region (P1 and viral RNA-dependent RNA polymerase (3D. Two mutations, E167D and L169F, were mapped to the VP1 canyon that binds the SCARB2 receptor on host cells. Another two mutations, S135T and K140I, were located in the VP2 neutralization epitope spanning amino acids 136-150. This is the first report of human EV71 with the ability to productively infect rodent cell lines in vitro.

  14. Phenotypic and genotypic characteristics of novel mouse cell line (NIH/3T3)-adapted human enterovirus 71 strains (EV71:TLLm and EV71:TLLmv).

    Science.gov (United States)

    Victorio, Carla Bianca Luena; Xu, Yishi; Ng, Qimei; Chow, Vincent T K; Chua, Kaw Bing

    2014-01-01

    Since its identification in 1969, Enterovirus 71 (EV71) has been causing periodic outbreaks of infection in children worldwide and most prominently in the Asia-Pacific Region. Understanding the pathogenesis of Enterovirus 71 (EV71) is hampered by the virus's inability to infect small animals and replicate in their derived in vitro cultured cells. This manuscript describes the phenotypic and genotypic characteristics of two selected EV71 strains (EV71:TLLm and EV71:TLLmv), which have been adapted to replicate in mouse-derived NIH/3T3 cells, in contrast to the original parental virus which is only able to replicate in primate cell lines. The EV71:TLLm strain exhibited productive infection in all primate and rodent cell lines tested, while EV71:TLLmv exhibited greater preference for mouse cell lines. EV71:TLLmv displayed higher degree of adaptation and temperature adaptability in NIH/3T3 cells than in Vero cells, suggesting much higher fitness in NIH/3T3 cells. In comparison with the parental EV71:BS strain, the adapted strains accumulated multiple adaptive mutations in the genome resulting in amino acid substitutions, most notably in the capsid-encoding region (P1) and viral RNA-dependent RNA polymerase (3D). Two mutations, E167D and L169F, were mapped to the VP1 canyon that binds the SCARB2 receptor on host cells. Another two mutations, S135T and K140I, were located in the VP2 neutralization epitope spanning amino acids 136-150. This is the first report of human EV71 with the ability to productively infect rodent cell lines in vitro.

  15. Broadband multilayer soft X-ray mirrors for attosecond pulse formation at photon energies above 100 eV

    Energy Technology Data Exchange (ETDEWEB)

    Hofstetter, Michael; Schuster, Joerg; Kleineberg, Ulf [LMU, Physik (Germany); Aquila, Andrew [CXRO (United States); Schulze, Martin; Fiess, Markus; Gouliemakis, Eleftherios; Krausz, Ferenc [MPQ (Germany); Huth, Martin [LMU, Chemie (Germany)

    2009-07-01

    We report on the development, fabrication and application of multilayer mirrors as broadband soft-X-ray optical components for the formation of attosecond (1 asec=10{sup -18}s)pulses from high harmonic radiation. Until recently, attosecond physics was merely confined to the photon energy range below 100 eV due to the properties of Mo/Si multilayer and single isolated pulses of 80 asec pulse duration have been achieved. For many applications, e.g. in the characterization of the photoemission dynamics from solid surfaces or the characterization of ultrafast surface plasmon dynamics in metallic nanostructures by attosecond pump-probe spectroscopy, higher photon energies are desirable to address deeper bound electronic core states or to increase the kinetic energy of the emitted photoelectrons. Here, we introduce new aperiodic broad bandwidth multilayer systems based on lanthanum (e.g. LaMo, LaB{sub 4}CMo, LaB{sub 4}C, MoB{sub 4}C),for the 100-190 eV photon energy range. Multilayer properties like interface roughness, interlayer formation and reflectivity are discussed. Finally, first applications for spectral filtering of the HHG comb above 100 eV are presented.

  16. Differential, integral, and momentum-transfer cross sections for elastic electron scattering by neon - 5 to 100 eV

    Science.gov (United States)

    Register, D. F.; Trajmar, S.

    1984-01-01

    Relative elastic-scattering differential cross sections were measured in the 5-100-eV impact energy and 10-145 deg angular ranges. Normalization of these cross sections was achieved by utilizing accurate total electron-scattering cross sections. A phase-shift analysis of the angular distributions in terms of real phase shifts has been carried out. From the differential cross sections, momentum-transfer cross sections were obtained and the values of the critical energy and angle were established (associated with the lowest value of the differential cross section) as 62.5 + or - 2.5 eV and 101.7 deg + or - 1.5 deg, respectively. The present phase shifts, the critical parameters, and differential, integral, and momentum-transfer cross sections are compared to previous experimental and theoretical results. The error associated with the present data is about 10 percent.

  17. An Instrument to Measure Elemental Energy Spectra of Cosmic Ray Nuclei Up to 10(exp 16) eV

    Science.gov (United States)

    Adams, J.; Bashindzhagyan, G.; Chilingarian, A.; Drury, L.; Egorov, N.; Golubkov,S.; Korotkova, N.; Panasyuk, M.; Podorozhnyi, D.; Procqureur, J.

    2000-01-01

    A longstanding goal of cosmic ray research is to measure the elemental energy spectra of cosmic rays up to and through the "knee" (approx. equal to 3 x 10 (exp 15) eV. It is not currently feasible to achieve this goal with an ionization calorimeter because the mass required to be deployed in Earth orbit is very large (at least 50 tonnes). An alternative method will be presented. This is based on measuring the primary particle energy by determining the angular distribution of secondaries produced in a target layer using silicon microstrip detector technology. The proposed technique can be used over a wide range of energies (10 (exp 11)- 10 (exp 16) eV) and gives an energy resolution of 60% or better. Based on this technique, a design for a new lightweight instrument with a large aperture (KLEM) will be described.

  18. New constraints on the mass composition of cosmic rays above 10^17 eV from Volcano Ranch measurements

    CERN Document Server

    Dova, M T; Mariazzi, A G; McCauley, T P; Watson, A A

    2003-01-01

    Linsley used the Volcano Ranch array to collect data on the lateral distribution of showers produced by cosmic rays at energies above 10^17 eV. Very precise measurements of the steepness of the lateral distribution function were made on 366 events. The current availability of sophisticated hadronic interaction models has prompted an interpretation of the measurements. In this analysis we use the AIRES Monte Carlo code to generate showers, together with GEANT4 to simulate the detector response to ground particles. The results show that, with the assumption of a bi-modal proton and iron mix, iron is the dominant component of cosmic rays between 5x10^17 and 10^19 eV, assuming that hadronic interactions are well-described by QGSJET at this energy range.

  19. Oxygen-carbon interactions in silicon: photoluminescence defect spectrum at 1.06 eV emission

    International Nuclear Information System (INIS)

    We report a new luminescent defect with non-phonon emission at 1.0595 eV in silicon irradiated at high electron doses in the 1018 cm-2 range. Doping studies and 12C/13C and 16O/18O isotopic line shifts demonstrate that the defect forms upon oxygen-carbon interaction. Luminescence measurements at higher temperatures exhibit excited features consistent with an effective-mass like electron spectrum classifying the defect as a hole trap with hole binding energy of ≅79 meV. Stress data also hint to shallow bound electron and reveal low symmetry (triclinic) of the core defect. Similarities with the Ci-Oi 0.79 eV defect ('C line') are pointed out. (author) 22 refs., 6 figs., 1 tab

  20. More is different: Reconciling eV sterile neutrinos with cosmological mass bounds

    Directory of Open Access Journals (Sweden)

    Yong Tang

    2015-11-01

    Full Text Available It is generally expected that adding light sterile species would increase the effective number of neutrinos, Neff. In this paper we discuss a scenario that Neff can actually decrease due to the neutrino oscillation effect if sterile neutrinos have self-interactions. We specifically focus on the eV mass range, as suggested by the neutrino anomalies. With large self-interactions, sterile neutrinos are not fully thermalized in the early Universe because of the suppressed effective mixing angle or matter effect. As the Universe cools down, flavor equilibrium between active and sterile species can be reached after big bang nucleosynthesis (BBN epoch, but leading to a decrease of Neff. In such a scenario, we also show that the conflict with cosmological mass bounds on the additional sterile neutrinos can be relaxed further when more light species are introduced. To be consistent with the latest Planck results, at least 3 sterile species are needed.

  1. More Is Different: Reconciling eV Sterile Neutrinos and Cosmological Mass Bounds

    CERN Document Server

    Tang, Yong

    2015-01-01

    It is generally expected that adding light sterile species would increase the effective number of neutrinos, $N_{\\textrm{eff}}$. In this paper we discuss a scenario that $N_{\\textrm{eff}}$ can actually decrease due to the neutrino oscillation effect if sterile neutrinos have self-interactions. We specifically focus on the eV mass range, as suggested by the neutrino anomalies. With large self-interactions, sterile neutrinos are not fully thermalized in the early Universe because of the suppressed effective mixing angle or matter effect. As the Universe cools down, flavor equilibrium between active and sterile species can be reached after big bang nucleosynthesis (BBN) epoch, but leading to a decrease of $N_{\\textrm{eff}}$. In such a scenario, we also show that the conflict with cosmological mass bounds on the additional sterile neutrinos can be relaxed further when more light species are introduced.

  2. Studies on keV and eV electrons in solids

    International Nuclear Information System (INIS)

    The interaction between keV or eV electrons and solids was studied. The results presented mostly concern problems in connection with electron irradiation of solids, but to some extent they also include ion-induced secondary electron emission. The experiments were mainly performed on solidified gases using 1 - 3 keV electrons. The projected range of electrons was determined in solid hydrogen, deuterium and nitrogen. The true secondary electron emission coefficient and the electron reflection coefficient of solid hydrogen, deuterium and nitrogen were measured. The escape depth of the true secondary electrons in nitrogen was determined. The angular dependence of both the reflection coefficient and the true secondary electron emission coefficient of solid hydrogen and deuterium was investigated. Both ion- and electron-induced secondary electron emission were treated theoretically on the basis of ionization cascade theory. (Auth.)

  3. EVS vs TIPS shunt for gastric variceal bleeding in patients with cirrhosis:A meta-analysis

    Institute of Scientific and Technical Information of China (English)

    Ming; Bai; Xing-Shun; Qi; Zhi-Ping; Yang; Kai-Chun; Wu; Dai-Ming; Fan; Guo-Hong; Han

    2014-01-01

    AIM: To evaluate the clinical effects of transjugular intrahepatic portosystemic shunt (TIPS) vs endoscopic variceal sclerotherapy (EVS) in the management of gastric variceal (GV) bleeding in terms of variceal rebleeding, hepatic encephalopathy (HE), and survival by meta-analysis.METHODS: Medline, Embase, and CNKI were searched. Studies compared TIPS with EVS in treating GV bleeding were identified and included according to our predefined inclusion criteria. Data were extracted independently by two of our authors. Studies with prospective randomized design were considered to be of high quality. Hazard ratios (HRs) or odd ratios(ORs) were calculated using a fixed-effects model when there was no inter-trial heterogeneity. Oppositely, a random-effects model was employed.RESULTS: Three studies with 220 patients who had at least one episode of GV bleeding were included in the present meta-analysis. The proportions of patients with viral cirrhosis and alcoholic cirrhosis were 39% (range 0%-78%) and 36% (range 12% to 41%), respectively. The pooled incidence of variceal rebleeding in the TIPS group was significantly lower than that in the EVS group (HR = 0.3, 0.35, 95% CI: 0.17-0.71, P = 0.004). However, the risk of the development of any degree of HE was significantly increased in the TIPS group (OR = 15.97, 95% CI: 3.61-70.68). The pooled HR of survival was 1.26(95% CI: 0.76-2.09, P = 0.36). No inter-trial heterogeneity was observed among these analyses. CONCLUSION: The improved effect of TIPS in the prevention of GV rebleeding is associated with an increased risk of HE. There is no survival difference between the TIPS and EVS groups. Further studies are needed to evaluate the survival benefit of TIPS in cirrhotic patients with GV bleeding.

  4. Experimental investigation on EV battery cooling and heating by heat pipes

    International Nuclear Information System (INIS)

    Enhancing battery safety and thermal behaviour are critical for electric vehicles (EVs) because they affect the durability, energy storage, lifecycle, and efficiency of the battery. Prior studies of using air, liquid or phase change materials (PCM) to manage the battery thermal environment have been investigated over the last few years, but only a few take heat pipes into account. This paper aims to provide a full experimental characterisation of heat pipe battery cooling and heating covering a range of battery ‘off-normal’ conditions. Two representative battery cells and a substitute heat source ranging from 2.5 to 40 W/cell have been constructed. Results show that the proposed method is able to keep the battery surface temperature below 40 °C if the battery generates less than 10 W/cell, and helps reduce the battery temperature down to 70 °C under uncommon thermal abuse conditions (e.g. 20–40 W/cell). Additionally, the feasibility of using sintered copper-water heat pipes under sub-zero temperatures has been assessed experimentally by exposing the test rig to −15 °C/−20 °C for more than 14 h. Data indicates that the heat pipe was able to function immediately after long hours of cold exposure and that sub-zero temperature conditions had little impact on heat pipe performance. We therefore conclude that the proposed method of battery cooling and heating via heat pipes is a viable solution for EVs

  5. Resonance and threshold effects in photoemission up to 3500 eV

    Energy Technology Data Exchange (ETDEWEB)

    Shirley, D.A.; Kobrin, P.H.; Lindle, D.W.; Truesdale, C.M.; Southworth, S.H.; Becker, U.; Kerkhoff, H.G.

    1982-08-01

    Beam lines at the Stanford Synchrotron Radiation Laboratory (SSRL) now provide photon beams throughout the entire energy range 5 to 5000 eV, with a pulse structure very well-suited to time-of-flight (TOF) photoelectron spectroscopy. We have used this facility, together with a TOF spectrometer, to measure photoemission cross sections sigma(epsilon) and asymmetry parameters ..beta..(epsilon) for several interesting systems. A summary of early results is given. Metal vapors (Ba, Cd, Mn, Hg) were studied using a high-temperature oven. Resonant photoemission was observed in several cases. Both sigma(epsilon) and ..beta..(epsilon) showed resonant behavior at 21.1 eV for several lines in Cd. The 4d, 5s, and 5p sigma(epsilon) line profiles differed dramatically, illustrating the detailed information about continuum states that is available from photoemission. Correlation satellites in photoemission from rare gases have been observed over a very wide energy range, including those seen in the K-shells of He, Ne and Ar and in the L-shell of Ne. The structure and preliminary intensity variations of these satellites will be discussed. Molecular shape resonances in C(1s), N(1s), and O(1s) photoemission were observed for the first time, in the molecules CO, CO/sub 2/, OCS, CF/sub 4/, N/sub 2/ and NO. Both the ..pi.. and sigma resonances were observed in KVV Auger emission, and the sigma resonances were studied by photoemission. The asymmetry parameters were measured in all cases. The results are in fair agreement with theory, but show systematic deviations and trends. 31 references.

  6. Both ERK1 and ERK2 are required for enterovirus 71 (EV71) efficient replication.

    Science.gov (United States)

    Zhu, Meng; Duan, Hao; Gao, Meng; Zhang, Hao; Peng, Yihong

    2015-03-01

    It has been demonstrated that MEK1, one of the two MEK isoforms in Raf-MEK-ERK1/2 pathway, is essential for successful EV71 propagation. However, the distinct function of ERK1 and ERK2 isoforms, the downstream kinases of MEKs, remains unclear in EV71 replication. In this study, specific ERK siRNAs and selective inhibitor U0126 were applied. Silencing specific ERK did not significantly impact on the EV71-caused biphasic activation of the other ERK isoform, suggesting the EV71-induced activations of ERK1 and ERK2 were non-discriminative and independent to one another. Knockdown of either ERK1 or ERK2 markedly impaired progeny EV71 propagation (both by more than 90%), progeny viral RNA amplification (either by about 30% to 40%) and protein synthesis (both by around 70%), indicating both ERK1 and ERK2 were critical and not interchangeable to EV71 propagation. Moreover, suppression of EV71 replication by inhibiting both early and late phases of ERK1/2 activation showed no significant difference from that of only blocking the late phase, supporting the late phase activation was more importantly responsible for EV71 life cycle. Taken together, this study for the first time identified both ERK1 and ERK2 were required for EV71 efficient replication and further verified the important role of MEK1-ERK1/2 in EV71 replication.

  7. Both ERK1 and ERK2 Are Required for Enterovirus 71 (EV71 Efficient Replication

    Directory of Open Access Journals (Sweden)

    Meng Zhu

    2015-03-01

    Full Text Available It has been demonstrated that MEK1, one of the two MEK isoforms in Raf-MEK-ERK1/2 pathway, is essential for successful EV71 propagation. However, the distinct function of ERK1 and ERK2 isoforms, the downstream kinases of MEKs, remains unclear in EV71 replication. In this study, specific ERK siRNAs and selective inhibitor U0126 were applied. Silencing specific ERK did not significantly impact on the EV71-caused biphasic activation of the other ERK isoform, suggesting the EV71-induced activations of ERK1 and ERK2 were non-discriminative and independent to one another. Knockdown of either ERK1 or ERK2 markedly impaired progeny EV71 propagation (both by more than 90%, progeny viral RNA amplification (either by about 30% to 40% and protein synthesis (both by around 70%, indicating both ERK1 and ERK2 were critical and not interchangeable to EV71 propagation. Moreover, suppression of EV71 replication by inhibiting both early and late phases of ERK1/2 activation showed no significant difference from that of only blocking the late phase, supporting the late phase activation was more importantly responsible for EV71 life cycle. Taken together, this study for the first time identified both ERK1 and ERK2 were required for EV71 efficient replication and further verified the important role of MEK1-ERK1/2 in EV71 replication.

  8. Determinants of EV71 immunogenicity and protection against lethal challenge in a mouse model.

    Science.gov (United States)

    Chang, Junliang; Li, Jingliang; Wei, Wei; Liu, Xin; Liu, Guanchen; Yang, Jiaxin; Zhang, Wenyan; Yu, Xiao-Fang

    2015-07-01

    Circulating enterovirus 71 (EV71)-associated hand, foot, and mouth disease (HFMD) is a major public health problem in the Asian-Pacific region. An EV71 vaccine for HFMD prevention is currently being developed. However, viral determinants that could influence the vaccine's efficacy have not been well characterized. In this study, we isolated and characterized several EV71 strains that are currently circulating in northern and southern China. We determined that VP1 variation is a major determinant of EV71 immunogenicity. A single amino acid variation in VP1 can lead to significant differences in the breadth and potency of immune responses against primary EV71 isolates as well as the sensitivity of EV71 to heterologous neutralizing antibody responses. We also identified EV71 strains that could induce potent immunogenic and cross-neutralizing antibody responses against diverse EV71 strains. Furthermore, these neutralizing antibodies could protect neonatal mice from lethal dose challenge with various circulating EV71 viruses. Our study provides useful information for EV71 vaccine development and evaluation.

  9. EV City Casebook: A Look At The Global Electric Vehicle Movement

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2012-07-01

    Electric vehicles (EVs) hold the potential of transforming the way the world moves. EVs can increase energy security by diversifying the fuel mix and decreasing dependence on petroleum, while also reducing emissions of greenhouse gases and other pollutants. Just as important, EVs can unlock innovation and create new advanced industries that spur job growth and enhance economic prosperity. However, the mass deployment of EVs will require transportation systems capable of integrating and fostering this new technology. To accelerate this transition, cities and metropolitan regions around the world are creating EV-friendly ecosystems and building the foundation for widespread adoption. In recognition of the importance of urban areas in the introduction and scale-up of electric vehicles, the EV City Casebook presents informative case studies on city and regional EV deployment efforts around the world. These case studies are illustrative examples of how pioneering cities are preparing the ground for mass market EV deployment. They offer both qualitative and quantitative information on cities' EV goals, progress, policies, incentives, and lessons learned to date. The purpose of the EV City Casebook is to share experiences on EV demonstration and deployment, identify challenges and opportunities, and highlight best practices for creating thriving EV ecosystems. These studies seek to enhance understanding of the most effective policy measures to foster the uptake of electric vehicles in urban areas. The cities represented here are actively engaging in a variety of initiatives that share the goal of accelerating EV adoption. This publication is the result of an effort to coordinate those initiatives and provide a global perspective on the electric vehicle movement. This international knowledge-sharing network consists of the Electric Vehicles Initiative (EVI), a multi-government initiative of the Clean Energy Ministerial; Project Get Ready, a Rocky Mountain Institute

  10. 手足口病的元凶—EV71

    Institute of Scientific and Technical Information of China (English)

    杨明巧

    2008-01-01

    什么是 EV71?最近时常有一些家长带着有一点发热、或身上起了几个皮疹的宝宝来到医院就诊,首先就询问医生:"我家宝宝是否感染了EV71?""EV71"确实已给家长心理上蒙上了阴影,造成了恐慌。那么,什么是 EV71呢?EV71是一种肠道病毒,虽然 EV71是肠道病毒,但是人感染

  11. Evolution of the cosmic ray anisotropy above 10^{14} eV

    CERN Document Server

    Aglietta, M; Alessandro, B; Antonioli, P; Arneodo, F; Bergamasco, L; Bertaina, M; Bonino, R; Castellina, A; Chiavassa, A; Piazzoli, B D'Ettorre; Di Sciascio, G; Fulgione, W; Galeotti, P; Ghia, P L; Iacovacci, M; Mannocchi, G; Morello, C; Navarra, G; Saavedra, O; Stamerra, A; Trinchero, G C; Valchierotti, S; Vallania, P; Vernetto, S; Vigorito, C

    2009-01-01

    The amplitude and phase of the cosmic ray anisotropy are well established experimentally between 10^{11} eV and 10^{14} eV. The study of their evolution into the energy region 10^{14}-10^{16} eV can provide a significant tool for the understanding of the steepening ("knee") of the primary spectrum. In this letter we extend the EAS-TOP measurement performed at E_0 around 10^{14} eV, to higher energies by using the full data set (8 years of data taking). Results derived at about 10^{14} and 4x10^{14} eV are compared and discussed. Hints of increasing amplitude and change of phase above 10^{14} eV are reported. The significance of the observation for the understanding of cosmic ray propagation is discussed.

  12. Determination of electron-heated temperatures of petawatt laser-irradiated foil targets with 256 and 68 eV extreme ultraviolet imaging

    International Nuclear Information System (INIS)

    Measurements of plasma temperature at the rear surface of foil targets due to heating by hot electrons, which were produced in short pulse high intensity laser matter interactions using the 150 J, 0.5 ps Titan laser, are reported. Extreme ultraviolet (XUV) imaging at 256 and 68 eV energies is used to determine spatially resolved target rear surface temperature patterns by comparing absolute intensities to radiation hydrodynamic modeling. XUV mirrors at these two energies were absolutely calibrated at the Advanced Light Source at the Lawrence Berkeley Laboratory. Temperatures deduced from both imagers are validated against each other within the range of 75-225 eV.

  13. Consistency of modified MLE in EV model with replicated observations

    Institute of Scientific and Technical Information of China (English)

    ZHANG; Sanguo

    2001-01-01

    [1]Kendall, M., Stuart, A., The Advanced Theory of Statistics, Vol. 2, New York: Charles Griffin, 1979.[2]Anderson, T. W., Estimating linear statistical relationships, Ann. Statist., 1984, 12: 1.[3]Cui Hengjian, Asymptotic normality of M-estimates in the EV model, Sys. Sci. and Math. Sci., 1997, 10(3): 225.[4]Madansky, A., The fitting of straight lines when both variables are subject to error, JASA, 1959, 54: 173.[5]Villegas, C., Maximum likelihood estimations of a linear functional relationship, Ann. Math. Statist., 1961, 32(4): 1048.[6]Stout, W. F., Almost Sure Convergence, New York: Academic Press, 1974.[7]Petrov, V. V., Sums of Independent Random Variables, New York: Springer-Verlag, 1975.[8]Lai, T. L., Robbins, H., Wei, C. Z., Strong consistency of least squares estimates in multiple regression, J. Multivariate Anal., 1979, 9: 343.[9]Chen Xiru, On limiting properties of U-statistics and von-Mises statistics, Scientia Sinica (in Chinese), 1980, (6): 522.

  14. Baseline Testing of the EV Global E-Bike SX

    Science.gov (United States)

    Eichenherg, Dennis J.; Kolacz, John S.; Tavernelli, Paul F.

    2001-01-01

    The NASA John H. Glenn Research Center initiated baseline testing of the EV Global E-Bike SX as an update of the state of the art in hybrid electric bicycles. The E-bike is seen as a way to reduce pollution in urban areas, reduce fossil fuel consumption, and reduce operating costs for transportation systems. The work was done under the Hybrid Power Management (HPM) Program, which includes the Hybrid Electric Transit Bus (HETB). The SX is a high performance, state of the art, ground up, hybrid electric bicycle. Unique features of the SX's 36 V power system include the use of an efficient, 400 W, electric hub motor, and a seven-speed derailleur system that permits operation as fully electric, fully pedal, or a combination of the two. Other innovative features, such as regenerative braking through ultracapacitor energy storage, are planned. Regenerative braking recovers much of the kinetic energy of the vehicle during deceleration. The E-Bike is an inexpensive approach to advance the state of the art in hybrid technology in a practical application. The project transfers space technology to terrestrial use via nontraditional partners, and provides power system data valuable for future space applications. A description of the SX, the results of performance testing, and future vehicle development plans are given in this report. The report concludes that the SX provides excellent performance, and that the implementation of ultracapacitors in the power system can provide significant performance improvements.

  15. Baseline Testing of The EV Global E-Bike

    Science.gov (United States)

    Eichenberg, Dennis J.; Kolacz, John S.; Tavernelli, Paul F.

    2001-01-01

    The NASA John H. Glenn Research Center initiated baseline testing of the EV Global E-Bike as a way to reduce pollution in urban areas, reduce fossil fuel consumption and reduce Operating costs for transportation systems. The work was done Linder the Hybrid Power Management (HPM) Program, which includes the Hybrid Electric Transit Bus (HETB). The E-Bike is a state of the art, ground up, hybrid electric bicycle. Unique features of the vehicle's power system include the use of an efficient, 400 W. electric hub motor and a 7-speed derailleur system that permits operation as fully electric, fully pedal, or a combination of the two. Other innovative features, such as regenerative braking through ultracapacitor energy storage are planned. Regenerative braking recovers much of the kinetic energy of the vehicle during deceleration. The E-Bike is an inexpensive approach to advance the state of the art in hybrid technology in a practical application. The project transfers space technology to terrestrial use via nontraditional partners, and provides power system data valuable for future space applications. A description of the E-bike, the results of performance testing, and future vehicle development plans is the subject of this report. The report concludes that the E-Bike provides excellent performance, and that the implementation of ultracapacitors in the power system can provide significant performance improvements.

  16. Absolute oscillator strength densities below 100eV of N2

    Institute of Scientific and Technical Information of China (English)

    Sun Jian-Min; Zhong Zhi-Ping; Zhu Lin-Fan; Liu Xiao-Jing; Yuan Zhen-Sheng; Xu Ke-Zun

    2005-01-01

    The absolute optical oscillator strength density (OOSD) and generalized oscillator strength densities (GOSDs)below 100eV of N2 are determined with an incident electron energy of 2500eV and an energy resolution of 100 meV.The absolute generalized oscillator strengths (GOSs) for two transitions to the superexcited states at 23 and 31.4eV are determined and their momentum transfer dependence behaviours are discussed.

  17. Measurement of the Cosmic Ray Energy Spectrum and Composition from 10^{17} to 10^{18.3} eV Using a Hybrid Fluorescence Technique

    CERN Document Server

    Abu-Zayyad, T; Bird, D J; Boyer, J; Cao, Z; Catanese, M; Chen, G F; Clay, R W; Covault, C E; Dai, H Y; Dawson, B R; Elbert, J W; Fick, B E; Fortson, Lucy F; Fowler, J W; Gibbs, K G; Glasmacher, M A K; Green, K D; Huang, A; Jui, C; Kidd, M J; Kieda, D B; Knapp, B C; Larsen, C G; Lee, W; Loh, E C; Mannel, E J; Matthews, J; Matthews, J N; Newport, B J; Nitz, D F; Ong, R A; Simpson, K M; Smith, J D; Sinclair, D; Sokolsky, P; Sommers, P; Song, C; Tang, J K K; Thomas, S B; Der Velde, J; Wiencke, L R; Wilkinson, C R; Yoshida, S; Zhang, X Z

    2001-01-01

    We study the spectrum and average mass composition of cosmic rays with primary energies between 10^{17} eV and 10^{18} eV using a hybrid detector consisting of the High Resolution Fly's Eye (HiRes) prototype and the MIA muon array. Measurements have been made of the change in the depth of shower maximum as a function of energy. A complete Monte Carlo simulation of the detector response and comparisons with shower simulations leads to the conclusion that the cosmic ray intensity is changing f rom a heavier to a lighter composition in this energy range. The spectrum is consistent with earlier Fly's Eye measurements and supports the previously found steepening near 4 \\times 10^{17} eV .

  18. MicroRNA-23b inhibits enterovirus 71 replication through downregulation of EV71 VPl protein.

    Science.gov (United States)

    Wen, Bai-ping; Dai, Hong-jian; Yang, Yue-huang; Zhuang, Yu; Sheng, Ru

    2013-01-01

    Enterovirus 71 (EV71) is one of the causative pathogens of hand-foot-and-mouth disease and effective antiviral agents and vaccines against this virus have, to date, not been available. MicroRNAs (miRNAs) are a recently discovered class of RNAs with the function of post-transcriptional gene expression regulation. It has been demonstrated that miRNAs play important roles in the complicated interaction network between virus and host, while few studies have explored the role of miRNAs in EV71 infection. A recent study showed that hsa-miR-23b was downregulated significantly in cell-infected viruses. To address this issue, biological software miRanda was first used to predict possible target sites of miR-23b at EV71 gene sequence, then to confirm it by luciferase assay. miR-23b mimics were transfected to verify its effects on infection of EV71. These results suggest that miR-23b and upregulation of miR-23b inhibited the replication of EV71 by targeting at EV71 3'UTR conserved sequence. Taken together, miR-23b could inhibit EV71 replication through downregulation of EV71 VPl protein. These results may enhance our understanding on the prevention and treatment of hand-foot-and-mouth disease caused by EV71 infection.

  19. A Novel Recombinant Enterovirus Type EV-A89 with Low Epidemic Strength in Xinjiang, China

    OpenAIRE

    Qin Fan; Yong Zhang; Lan Hu; Qiang Sun; Hui Cui; Dongmei Yan; Huerxidan Sikandaner; Haishu Tang; Dongyan Wang; Zhen Zhu; Shuangli Zhu; Wenbo Xu

    2015-01-01

    Enterovirus A89 (EV-A89) is a novel member of the EV-A species. To date, only one full-length genome sequence (the prototype strain) has been published. Here, we report the molecular identification and genomic characterization of a Chinese EV-A89 strain, KSYPH-TRMH22F/XJ/CHN/2011, isolated in 2011 from a contact of an acute flaccid paralysis (AFP) patient during AFP case surveillance in Xinjiang China. This was the first report of EV-A89 in China. The VP1 coding sequence of this strain demons...

  20. Fachagentur Nachwachsende Rohstoffe e.V. Annual report 2009/2010; Fachagentur Nachwachsende Rohstoffe e.V. (FNR). Jahresbericht 2009/2010

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2010-07-01

    The annual report of the Fachagentur Nachwachsende Rohstoffe e.V. (Guelzow-Pruezen, Federal Republic of Germany) outlines the cultivation of industrial crops and energy plants. The organisational structure of the association and its research projects are presented.

  1. Fachagentur Nachwachsende Rohstoffe e.V. Annual report 2010/2011; Fachagentur Nachwachsende Rohstoffe e.V. (FNR). Jahresbericht 2010/2011

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2011-07-01

    The annual report of the Fachagentur Nachwachsende Rohstoffe e.V. (Guelzow-Pruezen, Federal Republic of Germany) outlines the cultivation of industrial crops and energy plants. The organisational structure of the association and its research projects are presented.

  2. Purification technology of hand -foot -and -mouth disease EV71 vaccine%手足口病EV71疫苗纯化的工艺

    Institute of Scientific and Technical Information of China (English)

    蔺芳; 穆瑞瑞; 张俊; 张可

    2012-01-01

    @@%为提高肠道病毒71型(EV71)疫苗的纯化工艺,采用粗纯、4FF层析、离子交换层析、蔗糖密度梯度离心等方法进行疫苗的纯化.结果表明,粗纯的EV71浓缩液经4FF层析和蔗糖密度梯度离心,得到高纯度的EV71疫苗.新工艺提高了EV71的纯度,适用于规模化生产.

  3. The cosmic ray spectrum and composition measured by KASCADE-Grande between 10{sup 16} eV and 10{sup 18} eV

    Energy Technology Data Exchange (ETDEWEB)

    Bertaina, M., E-mail: bertaina@to.infn.it [Department of Physics, University of Torino and INFN, Torino (Italy); Apel, W.D. [Institut für Kernphysik, KIT – Karlsruher Institut für Technologie (Germany); Arteaga-Velázquez, J.C. [Institute of Physics and Mathematics, Universidad Michoacana de San Nicolas de Hidalgo, Morelia (Mexico); Bekk, K. [Institut für Kernphysik, KIT – Karlsruher Institut für Technologie (Germany); Blümer, J. [Institut für Kernphysik, KIT – Karlsruher Institut für Technologie (Germany); Institut für Experimentelle Kernphysik, KIT – Karlsruher Institut für Technologie (Germany); Bozdog, H. [Institut für Kernphysik, KIT – Karlsruher Institut für Technologie (Germany); Brancus, I.M. [Horia Hulubei National Institute of Physics and Nuclear Engineering, Bucharest (Romania); Cantoni, E. [Department of Physics, University of Torino and INFN, Torino (Italy); Osservatorio Astrofisico di Torino, INAF Torino (Italy); Chiavassa, A. [Department of Physics, University of Torino and INFN, Torino (Italy); Cossavella, F. [Institut für Experimentelle Kernphysik, KIT – Karlsruher Institut für Technologie (Germany); Daumiller, K. [Institut für Kernphysik, KIT – Karlsruher Institut für Technologie (Germany); Souza, V. de [Universidade São Paulo, Instituto de Física de São Carlos (Brazil); and others

    2014-11-15

    The shape and composition of the primary spectrum of cosmic rays are key elements to understand the origin, acceleration and propagation of the Galactic cosmic rays. Besides the well known knee and ankle features, the recent results of KASCADE-Grande indicate that the measured energy spectrum exhibits also a less pronounced but still clear deviation from a single power law between the knee and the ankle, with a spectral hardening at 2 × 10{sup 16} eV and a steepening at 10{sup 17} eV. The average mass composition gets heavier after the knee till 10{sup 17} eV where a bending of the heavy component is observed. An indication of a hardening of the light component just above 10{sup 17} eV has been measured as well. In this paper the major results obtained so far by the KASCADE-Grande experiment are reviewed.

  4. Development of A Quantitative ELISA Method for EV71 Antigen%EV71抗原ELISA定量检测方法的建立

    Institute of Scientific and Technical Information of China (English)

    贾卉; 蔡芳; 高强; 张建三; 井申荣

    2010-01-01

    目的 建立EV71抗原双抗体夹心ELISA定量检测方法,用于EV71灭活疫苗生产过程中抗原含量的检测.方法 采用EV71全病毒免疫,制备抗EV71单克隆抗体及多克隆抗体,以抗EV71多克隆抗体作为包被抗体,经HRP标记的抗EV71单克隆抗体作为酶标抗体,建立双抗体夹心ELISA法,检测样品中EV71抗原含量,并对该方法进行验证及应用.结果 所建立的方法线性范围为5~80 U/ml,R~2=0.994,线性关系良好,定量限度为5 U/ml;检测不同浓度的EV71抗原内部参考品,回收率为88%~119.0%;变异系数均小于15%;与甲肝病毒收获液、乙脑病毒灭活液、H5N1流感病毒裂解疫苗原液、小牛血清、人白蛋白、Veto细胞、MEM培养基及CoxA16收获液均无交叉反应;检测EV71灭活疫苗原液纯化过程样品的抗原含量,能有效反映抗原纯化趋势;检测铝吸附疫苗成品解离后抗原含量,准确性较高.结论 已建立了EV71抗原双抗体夹心ELISA定量检测方法,该方法线性好,特异性强,灵敏度高,准确性及重复性良好,可用于EV71疫苗生产过程中及终产品的抗原定量检测.

  5. Fachagentur Nachwachsende Rohstoffe e.V. (FNR). Annual report 1999/2000; Fachagentur Nachwachsende Rohstoffe e.V. (FNR). Jahresbericht 1999/2000

    Energy Technology Data Exchange (ETDEWEB)

    Schuette, A.

    2001-07-01

    The annual report of the Fachagentur Nachwachsende Rohstoffe e.V. outlines the state of the art and the boundary conditions of energy plant utilisation. The organisational struture of the association and its research projects are presented. [German] Der Jahresbericht der Fachagentur Nachwachsende Rohstoffe e.V. stellt Stand der Technik und Rahmenbedingungen fuer die Verwendung von Energiepflanzen dar. Die Organisation des Vereins sowie die gefoerderten Forschungsprojekte werden vorgestellt.

  6. CDMA 1x EV-DO覆盖模型的分析与仿真%Analysis and Simulation of CDMA 1x EV-DO Coverage Model

    Institute of Scientific and Technical Information of China (English)

    梅琼

    2006-01-01

    结合经过校正后的适合于本地无线环境的OKUMURA-HATA传播模型,建立起一种新的本地化基于1x EV-DO系统数据业务吞吐量分析的覆盖预测仿真模型,可应用于1x EV-DO系统的网络规划及系统性能分析.

  7. 捕获ELISA法测定抗EV71-IgM抗体用于EV71感染早期诊断

    Institute of Scientific and Technical Information of China (English)

    林裕龙; 温坤; 王压娣; 晋晶; 车小燕

    2012-01-01

    目的 探讨捕获ELISA法测定抗肠道病毒71型(EV71) IgM抗体在EV71感染所致手足口病(HFMD)早期诊断中的价值.方法 以实时荧光RT-PCR检测89例临床初诊为HFMD患儿的粪便、疱疹液、咽拭子或肛拭子的肠道病毒RNA.用40例排除HFMD的5岁以下儿童血清为抗EV71-IgM抗体阴性对照,以捕获ELISA法检测患儿不同发病期血清中抗EV71 -IgM抗体.结果 经实时荧光RT-PCR检测,89例HFMD患儿粪便、疱疹液、咽拭子或肛拭子中EV71感染28例,柯萨奇病毒A16(CA16)感染43例,非EV71和CA16的肠道病毒感染14例,非肠道病毒感染4例.EV71感染者发病1~3d、4~6d及>6d的血清抗EV71 -IgM抗体阳性率分别为81.3%、100%和100%;CA16感染者分别为10.0%、26.4%和65.7%;非EV71和CA16的肠道病毒感染者及非肠道病毒感染者在发病1~3d和4~6d无1例阳性;阴性对照组无1例阳性.抗EV71-IgM抗体在EV71感染的早期(急性期)的诊断敏感性和特异性分别为81.3%和92.9%.结论 EV71感染者与CA16感染者血清抗EV71-IgM抗体在发病4d后存在较明显的交叉反应.抗EV71-IgM抗体可用作EV71感染早期诊断的血清学标志物.

  8. Extending the dose range: Probing deep traps in quartz with 3.06 eV photons

    DEFF Research Database (Denmark)

    Jain, Mayank

    2009-01-01

    This article demonstrates that violet (405 nm) stimulated luminescence (VSL) signal from quartz contains contribution from deep traps that are otherwise not accessible with blue light (470 nm). Additionally, it also contains the typical fast and slow components observed with the blue light stimul...

  9. Measurements of lambda and chi parameters for excitation of the 21P state of helium at 80 eV

    International Nuclear Information System (INIS)

    Electron-photon angular correlations have been measured for excitation of the 21P state of helium at an incident energy of 80 eV over the range 10-1150 of electron scattering angles. analysis of the data yields values for the alignment and orientation parameters lambda and |chi| which are in excellent agreement with data of Hollywood et al (J. Phys. B.; 12: 819 (1979)) but the data for lambda are in marked disagreement with the results of Steph and Golden (preprint. Univ. of Oklahoma (1979)) at electron scattering angles thetasub(c)> 700. (author)

  10. Workplace Charging Behavior of Nissan Leafs in The EV Project at Six Work Sites

    Energy Technology Data Exchange (ETDEWEB)

    David Rohrbaugh; John Smart

    2014-11-01

    This paper documents findings from analysis of data collected from Nissan Leafs enrolled in The EV Project who parked and charged at six workplaces with EV charging equipment. It will be published as a white paper on INL's website, accessible by the general public.

  11. Catalytic Assessment: Understanding How MCQs and EVS Can Foster Deep Learning

    Science.gov (United States)

    Draper, Stephen W.

    2009-01-01

    One technology for education whose adoption is currently expanding rapidly in UK higher education is that of electronic voting systems (EVS). As with all educational technology, whether learning benefits are achieved depends not on the technology but on whether an improved teaching method is introduced with it. EVS inherently relies on the…

  12. Comparison of the LEGO Mindstorms NXT and EV3 Robotics Education Platforms

    Science.gov (United States)

    Sherrard, Ann; Rhodes, Amy

    2014-01-01

    The release of the latest LEGO Mindstorms EV3 robotics platform in September 2013 has provided a dilemma for many youth robotics leaders. There is a need to understand the differences in the Mindstorms NXT and EV3 in order to make future robotics purchases. In this article the differences are identified regarding software, hardware, sensors, the…

  13. Sõlmornamendist, eriti muinaskäevõrudel ja setu naiste ülerõivastel / Mare Piho

    Index Scriptorium Estoniae

    Piho, Mare, 1944-

    2006-01-01

    Artikli ajendiks sai 1972. aastal Setumaalt juhuleiuna saadud 11. sajandi käevõru. Käevõrul kujutaud plettornamenti on kasutatud setu naiste 19. sajandi keskpaiga - 20. sajandi riietelel. Sõlmest kui märgist ja selle tähendusest. Sõlmornamendist setu naiste pealisriietel. Sõlmornamendi järjepidevusest ja püsimisest

  14. EV71 vaccine, a new tool to control outbreaks of hand, foot and mouth disease (HFMD).

    Science.gov (United States)

    Mao, Qun-ying; Wang, Yiping; Bian, Lianlian; Xu, Miao; Liang, Zhenglun

    2016-05-01

    On December 3rd 2015, the China Food and Drug Administration (CFDA) approved the first inactivated Enterovirus 71 (EV71) whole virus vaccine for preventing severe hand, foot and mouth disease (HFMD). As one of the few preventive vaccines for children's infectious diseases generated by the developing countries in recent years, EV71 vaccine is a blessing to children's health in China and worldwide. However, there are still a few challenges facing the worldwide use of EV71 vaccine, including the applicability against various EV71 pandemic strains in other countries, international requirements on vaccine production and quality control, standardization and harmonization on different pathogen monitoring and detecting methods, etc. In addition, the affordability of EV71 vaccine in other countries is a factor to be considered in HFMD prevention. Therefore, with EV71 vaccine commercially available, there is still a long way to go before reaching effective protection against severe HFMD after EV71 vaccines enter the market. In this paper, the bottlenecks and prospects for the wide use of EV71 vaccine after its approval are evaluated.

  15. Immunogenicity Studies of Bivalent Inactivated Virions of EV71/CVA16 Formulated with Submicron Emulsion Systems

    Directory of Open Access Journals (Sweden)

    Chih-Wei Lin

    2014-01-01

    Full Text Available We assessed two strategies for preparing candidate vaccines against hand, foot, and mouth disease (HFMD caused mainly by infections of enterovirus (EV 71 and coxsackievirus (CV A16. We firstly design and optimize the potency of adjuvant combinations of emulsion-based delivery systems, using EV71 candidate vaccine as a model. We then perform immunogenicity studies in mice of EV71/CVA16 antigen combinations formulated with PELC/CpG. A single dose of inactivated EV71 virion (0.2 μg emulsified in submicron particles was found (i to induce potent antigen-specific neutralizing antibody responses and (ii consistently to elicit broad antibody responses against EV71 neutralization epitopes. A single dose immunogenicity study of bivalent activated EV71/CVA16 virion formulated with either Alum or PELC/CpG adjuvant showed that CVA16 antigen failed to elicit CVA16 neutralizing antibody responses and did not affect EV71-specific neutralizing antibody responses. A boosting dose of emulsified EV71/CVA16 bivalent vaccine candidate was found to be necessary to achieve high seroconversion of CVA16-specific neutralizing antibody responses. The current results are important for the design and development of prophylactic vaccines against HFMD and other emerging infectious diseases.

  16. Immunogenicity studies of bivalent inactivated virions of EV71/CVA16 formulated with submicron emulsion systems.

    Science.gov (United States)

    Lin, Chih-Wei; Liu, Chia-Chyi; Lu, Tsung-Chun; Liu, Shih-Jen; Chow, Yen-Hung; Chong, Pele; Huang, Ming-Hsi

    2014-01-01

    We assessed two strategies for preparing candidate vaccines against hand, foot, and mouth disease (HFMD) caused mainly by infections of enterovirus (EV) 71 and coxsackievirus (CV) A16. We firstly design and optimize the potency of adjuvant combinations of emulsion-based delivery systems, using EV71 candidate vaccine as a model. We then perform immunogenicity studies in mice of EV71/CVA16 antigen combinations formulated with PELC/CpG. A single dose of inactivated EV71 virion (0.2 μg) emulsified in submicron particles was found (i) to induce potent antigen-specific neutralizing antibody responses and (ii) consistently to elicit broad antibody responses against EV71 neutralization epitopes. A single dose immunogenicity study of bivalent activated EV71/CVA16 virion formulated with either Alum or PELC/CpG adjuvant showed that CVA16 antigen failed to elicit CVA16 neutralizing antibody responses and did not affect EV71-specific neutralizing antibody responses. A boosting dose of emulsified EV71/CVA16 bivalent vaccine candidate was found to be necessary to achieve high seroconversion of CVA16-specific neutralizing antibody responses. The current results are important for the design and development of prophylactic vaccines against HFMD and other emerging infectious diseases.

  17. Progress on the research and development of inactivated EV71 whole-virus vaccines.

    Science.gov (United States)

    Liang, Zheng-Lun; Mao, Qun-Ying; Wang, Yi-Ping; Zhu, Feng-Cai; Li, Jing-Xin; Yao, Xin; Gao, Fan; Wu, Xing; Xu, Miao; Wang, Jun-Zhi

    2013-08-01

    The prevalence of diseases caused by EV71 infection has become a serious public health problem in the Western Pacific region. Due to a lack of effective treatment options, controlling EV71 epidemics has mainly focused on the research and development (R&D) of EV71 vaccines. Thus far, five organizations have completed pre-clinical studies focused on the development of inactivated EV71 whole-virus vaccines, including vaccine strain screening, process optimization, safety and immunogenicity evaluation, and are in different stages of clinical trials. Among these organizations, three companies in Mainland China [Beijing Vigoo Biological Co., Ltd. (Vigoo), Sinovac Biotech Ltd. (Sinovac) and Institute of Medical Biology, Chinese Academy of Medical Science (CAMS)] have recently completed Phase III trials for the vaccines they developed. In addition, the other two vaccines, developed by National Health Research Institutes (NHRI) of Taiwan and Inviragen Pte., Ltd (Inviragen), of Singapore, have also completed Phase I clinical trials. Published clinical trial results indicate that the inactivated EV71 vaccines have good safety and immunogenicity in the target population (infants) and confer a relatively high rate of protection against EV71 infection-related diseases. The results of clinical trials suggest a promising future for the clinical use of EV71 vaccines. Here, we review and highlight the recent progress on the R&D of inactivated EV71 whole-virus vaccines.

  18. Discovery of gramine derivatives that inhibit the early stage of EV71 replication in vitro.

    Science.gov (United States)

    Wei, Yanhong; Shi, Liqiao; Wang, Kaimei; Liu, Manli; Yang, Qingyu; Yang, Ziwen; Ke, Shaoyong

    2014-01-01

    Enterovirus 71 (EV71) is a notable causative agent of hand, foot, and mouth disease in children, which is associated with an increased incidence of severe neurological disease and death, yet there is no specific treatment or vaccine for EV71 infections. In this study, the antiviral activity of gramine and 21 gramine derivatives against EV71 was investigated in cell-based assays. Eighteen derivatives displayed some degree of inhibitory effects against EV71, in that they could effectively inhibit virus-induced cytopathic effects (CPEs), but the anti-EV71 activity of the lead compound gramine was not observed. Studies on the preliminary modes of action showed that these compounds functioned by targeting the early stage of the EV71 lifecycle after viral entry, rather than inactivating the virus directly, inhibiting virus adsorption or affecting viral release from the cells. Among these derivatives, one (compound 4s) containing pyridine and benzothiazole units showed the most potency against EV71. Further studies demonstrated that derivative 4s could profoundly inhibit viral RNA replication, protein synthesis, and virus-induced apoptosis in RD cells. These results indicate that derivative 4s might be a feasible therapeutic agent against EV71 infection and that these gramine derivatives may provide promising lead scaffolds for the further design and synthesis of potential antiviral agents.

  19. [Inactivation of EV71 by Exposure to Heat and Ultraviolet Light].

    Science.gov (United States)

    Xie, Jing; Li, Dandi; Xie, Guangcheng; Hu, Yaqian; Zhang, Qing; Kong, Xiangyu; Guo, Nijun; Li, Yuning; Duan, Zhaojun

    2015-09-01

    Enterovirus 71 (EV71) is a major agent of hand, foot and mouth disease that can cause a severe burden of disease to children. To identify an effective method for the control and prevention of EV71, we studied the effect of exposure to heat and ultraviolet (UV) light upon EV71 inactivation. We found that exposure to 50 degrees C could not inactivate the infectivity of EV71. However, exposure to 60 degrees C and 70 degrees C could inactivate EV71 effectively. EV71 could be inactivated after exposure to UV light at a distance between the sample and a lamp of 30 cm for 30 min or 60 min because viral genomic RNA was destroyed. However, fetal bovine serum (FBS) could attenuate the inactivation proffered by heat and UV light. Attenuation effects of FBS were correlated positively with FBS concentration. Hence, EV71 can be inactivated by exposure to heat and UV light, and our results could provide guidance on prevention of the spread of EV71.

  20. Optimization and control method for smart charging of EVs facilitated by Fleet operator

    DEFF Research Database (Denmark)

    Hu, Junjie; You, Shi; Si, Chengyong;

    2013-01-01

    -tion and the facilitator EV fleet operator are introduced. Secondly, control architec-tures and their integrations in term of electricity market and distribution grid are discussed. Then, data analysis of EVs including a battery model and driving pattern is presented. Further discussion is given on mathematical modelling...

  1. EV71 vaccine, a new tool to control outbreaks of hand, foot and mouth disease (HFMD).

    Science.gov (United States)

    Mao, Qun-Ying; Wang, Yiping; Bian, Lianlian; Xu, Miao; Liang, Zhenglun

    2016-05-01

    On December 3rd 2015, the China Food and Drug Administration (CFDA) approved the first inactivated Enterovirus 71 (EV71) whole virus vaccine for preventing severe hand, foot and mouth disease (HFMD). As one of the few preventive vaccines for children's infectious diseases generated by the developing countries in recent years, EV71 vaccine is a blessing to children's health in China and worldwide. However, there are still a few challenges facing the worldwide use of EV71 vaccine, including the applicability against various EV71 pandemic strains in other countries, international requirements on vaccine production and quality control, standardization and harmonization on different pathogen monitoring and detecting methods, etc. In addition, the affordability of EV71 vaccine in other countries is a factor to be considered in HFMD prevention. Therefore, with EV71 vaccine commercially available, there is still a long way to go before reaching effective protection against severe HFMD after EV71 vaccines enter the market. In this paper, the bottlenecks and prospects for the wide use of EV71 vaccine after its approval are evaluated. PMID:26732723

  2. Driving and Charging Behavior of Nissan Leafs in The EV Project with Access to Workplace Charging

    Energy Technology Data Exchange (ETDEWEB)

    Don Scoffield; Shawn Salisbury; John Smart

    2014-11-01

    This paper documents findings from analysis of data collected from Nissan Leafs enrolled in The EV Project who parked and charged at workplaces with EV charging equipment. It will be published as a white paper on INL's website, accessible by the general public.

  3. Cosmic rays: the spectrum and chemical composition from $10^{10}$ to $10^{20}$ eV

    CERN Document Server

    Peixoto, C J Todero; Biermann, Peter L

    2015-01-01

    The production of energetic particles in the universe remains one of the great mysteries of modern science. The mechanisms of acceleration in astrophysical sources and the details about the propagation through the galactic and extragalactic media are still to be defined. In recent years, the cosmic ray flux has been measured with high precision in the energy range from \\energy{10} to \\energyEV{20.5} by several experiments using different techniques. In some energy ranges, it has been possible to determine the flux of individual elements (hydrogen to iron nuclei). This paper explores an astrophysical scenario in which only our Galaxy and the radio galaxy Cen A produce all particles measured on Earth in the energy range from \\energy{10} to \\energyEV{20.5}. Data from AMS-02, CREAM, KASCADE, KASCADE-Grande and the Pierre Auger Observatories are considered. The model developed here is able to describe the total and individual particle flux of all experiments considered. It is shown that the theory used here is abl...

  4. Cross sections for 14-eV e-H2 resonant collisions: Isotope effect in dissociative electron attachment

    International Nuclear Information System (INIS)

    The process of dissociative attachment of electrons to molecular hydrogen and its isotopes in the energy range at approximately 14 eV is investigated. The dissociative electron attachment cross sections for all six hydrogen isotopes are calculated over an extended range of electron energies using the local complex potential model with the excited Rydberg 2Σg+ electronic state of H2- acting as the intermediate resonant state. A significant isotope effect in theoretical electron attachment cross sections is observed, in agreement with previous predictions and experimental observations. A two-parameter analytic expression for the cross section is derived from the theory that fits accurately the numerically calculated cross sections for all isotopes. Similarly, an analytic mass-scaling relation is derived from the theory that accurately reproduces the numerically calculated rate coefficients for all isotopes in the 0.1-1000 eV temperature range by using the rate coefficient for the H2 isotope only. The latter is represented by an analytic fit expression with two parameters only.

  5. Design, synthesis, and biological evaluation of anti-EV71 agents.

    Science.gov (United States)

    Li, Peng; Yang, Bailing; Hao, Fei; Wang, Ping; He, Haiying; Huang, Lei; Zhang, Xuan; Zhang, Shengbin; Peng, Xuanjia; Yin, Ke; Hu, Jiao; Chen, Xinsheng; Gu, Zhengxian; Wang, Li; Shen, Liang; Hu, Guoping; Li, Ning; Li, Jian; Chen, Shuhui; Xiao, Wei; Wang, Zhenzhong; Guo, Qingming; Chang, Xiujuan; Zhang, Lanjun; Cai, Qixu; Lin, Tianwei

    2016-07-15

    Enterovirus 71 (EV71) is a major causative agent of hand, foot and mouth disease (HFMD), which can spread its infections to the central nervous and other systems with severe consequences. In this article, design, chemical synthesis, and biological evaluation of various anti-EV71 agents which incorporate Michael acceptors are described. Further SAR study demonstrated that lactone type of Michael acceptor provided a new lead of anti-EV71 drug candidates with high anti-EV71 activity in cell-based assay and enhanced mouse plasma stability. One of the most potent compounds (2K, cell-based anti-EV71 EC50=0.028μM), showed acceptable stability profile towards mouse plasma, which resulted into promising pharmacokinetics in mouse via IP administration. PMID:27234148

  6. Design, synthesis, and biological evaluation of anti-EV71 agents.

    Science.gov (United States)

    Li, Peng; Yang, Bailing; Hao, Fei; Wang, Ping; He, Haiying; Huang, Lei; Zhang, Xuan; Zhang, Shengbin; Peng, Xuanjia; Yin, Ke; Hu, Jiao; Chen, Xinsheng; Gu, Zhengxian; Wang, Li; Shen, Liang; Hu, Guoping; Li, Ning; Li, Jian; Chen, Shuhui; Xiao, Wei; Wang, Zhenzhong; Guo, Qingming; Chang, Xiujuan; Zhang, Lanjun; Cai, Qixu; Lin, Tianwei

    2016-07-15

    Enterovirus 71 (EV71) is a major causative agent of hand, foot and mouth disease (HFMD), which can spread its infections to the central nervous and other systems with severe consequences. In this article, design, chemical synthesis, and biological evaluation of various anti-EV71 agents which incorporate Michael acceptors are described. Further SAR study demonstrated that lactone type of Michael acceptor provided a new lead of anti-EV71 drug candidates with high anti-EV71 activity in cell-based assay and enhanced mouse plasma stability. One of the most potent compounds (2K, cell-based anti-EV71 EC50=0.028μM), showed acceptable stability profile towards mouse plasma, which resulted into promising pharmacokinetics in mouse via IP administration.

  7. Optical properties of sputtered hexagonal CdZnO films with band gap energies from 1.8 to 3.3 eV

    Energy Technology Data Exchange (ETDEWEB)

    Ma Xiangyang; Chen Peiliang; Zhang Ruijie [State Key Laboratory of Silicon Materials and Department of Materials Science and Engineering, Zhejiang University, Hangzhou 310027 (China); Yang Deren, E-mail: mseyang@zju.edu.cn [State Key Laboratory of Silicon Materials and Department of Materials Science and Engineering, Zhejiang University, Hangzhou 310027 (China)

    2011-06-09

    Highlights: > Cd{sub x}Zn{sub 1-x}O films in a wide range of Cd contents were grown by reactive direct-current magnetron sputtering, which is a simple and widely used method. > The optical band gap energies of Cd{sub x}Zn{sub 1-x}O films were tuned from {approx} 3.3 eV to {approx} 1.8 eV. > The ultraviolet irradiation enhanced photoluminescence from the Cd{sub x}Zn{sub 1-x}O films was observed. - Abstract: Cd{sub x}Zn{sub 1-x}O films in a wide range of Cd contents have been grown by reactive direct-current magnetron sputtering. At x {<=} 0.66, the sputtered Cd{sub x}Zn{sub 1-x}O films are of single hexagonal phase. The optical band gap energies of the Cd{sub x}Zn{sub 1-x}O films decrease from {approx}3.3 eV at x = 0 to {approx}1.8 eV at x = 0.66. Correspondingly, the near-band-edge photoluminescence is tuned in a wide visible region from {approx}378 to 678 nm. Moreover, the ultraviolet irradiation enhanced PL from the Cd{sub x}Zn{sub 1-x}O films has been observed.

  8. Combined experimental and theoretical study on the differential elastic scattering cross sections for acetone by electron impact energy of 7.0-50 eV

    Science.gov (United States)

    Pastega, D. F.; Lange, E.; Ameixa, J.; Barbosa, A. S.; Blanco, F.; García, G.; Bettega, M. H. F.; Limão-Vieira, P.; Ferreira da Silva, F.

    2016-03-01

    We report elastic differential cross sections (DCSs) for electron interactions with acetone, C3H6O . The incident electron energy range was 7.0-50 eV, and the scattered electron angular range for the differential measurements varied from 10° to 120°. The calculated cross sections were obtained with two different methodologies, the Schwinger multichannel method with pseudopotentials (SMCPP), and the independent-atom method with screening-corrected additivity rule (IAM-SCAR). The present elastic DCSs have been found to agree well with the results of IAM-SCAR calculations above 20 eV, and also with the SMC calculations below 30 eV. Although some discrepancies were found for lower energies, the agreement between the SMCPP data and the DCSs obtained with the IAM-SCAR method improves, as expected, as the impact energy increases. Comparison with previous DCSs shows good agreement albeit the present data is extended down to lower electron impact energies. We find a low-lying π* shape resonance located at 2.6 eV, in agreement with recent results on electron collisions with acetone [M. G. P. Homem et al., Phys. Rev. A 92, 032711 (2015), 10.1103/PhysRevA.92.032711]. The presence of a σ* resonance is also discussed.

  9. Evaluating FOMC forecast ranges: an interval data approach

    OpenAIRE

    Fischer, Henning; García-Bárzana, Marta; Tillmann, Peter; Winker, Peter

    2012-01-01

    The Federal Open Market Committee (FOMC) of the U.S. Federal Reserve publishes the range of members' forecasts for key macroeconomic variables, but not the distribution of forecasts within this range. To evaluate these projections, previous papers compare the midpoint of the ranges with the realized outcome. This paper proposes a new approach to forecast evaluation that takes account of the interval nature of projections. It is shown that using the conventional Mincer-Zarnowitz approach to ev...

  10. A clinically authentic mouse model of enterovirus 71 (EV-A71)-induced neurogenic pulmonary oedema.

    Science.gov (United States)

    Victorio, Carla Bianca Luena; Xu, Yishi; Ng, Qimei; Chua, Beng Hooi; Alonso, Sylvie; Chow, Vincent T K; Chua, Kaw Bing

    2016-01-01

    Enterovirus 71 (EV-A71) is a neurotropic virus that sporadically causes fatal neurologic illness among infected children. Animal models of EV-A71 infection exist, but they do not recapitulate in animals the spectrum of disease and pathology observed in fatal human cases. Specifically, neurogenic pulmonary oedema (NPE)-the main cause of EV-A71 infection-related mortality-is not observed in any of these models. This limits their utility in understanding viral pathogenesis of neurologic infections. We report the development of a mouse model of EV-A71 infection displaying NPE in severely affected animals. We inoculated one-week-old BALB/c mice with an adapted EV-A71 strain and identified clinical signs consistent with observations in human cases and other animal models. We also observed respiratory distress in some mice. At necropsy, we found their lungs to be heavier and incompletely collapsed compared to other mice. Serum levels of catecholamines and histopathology of lung and brain tissues of these mice strongly indicated onset of NPE. The localization of virally-induced brain lesions also suggested a potential pathogenic mechanism for EV-A71-induced NPE. This novel mouse model of virally-induced NPE represents a valuable resource for studying viral mechanisms of neuro-pathogenesis and pre-clinical testing of potential therapeutics and prophylactics against EV-A71-related neurologic complications. PMID:27357918

  11. Management approach for NASA's Earth Venture-1 (EV-1) airborne science investigations

    Science.gov (United States)

    Guillory, Anthony R.; Denkins, Todd C.; Allen, B. Danette

    2013-09-01

    The Earth System Science Pathfinder (ESSP) Program Office (PO) is responsible for programmatic management of National Aeronautics and Space Administration's (NASA) Science Mission Directorate's (SMD) Earth Venture (EV) missions. EV is composed of both orbital and suborbital Earth science missions. The first of the Earth Venture missions is EV-1, which are Principal Investigator-led, temporally-sustained, suborbital (airborne) science investigations costcapped at $30M each over five years. Traditional orbital procedures, processes and standards used to manage previous ESSP missions, while effective, are disproportionally comprehensive for suborbital missions. Conversely, existing airborne practices are primarily intended for smaller, temporally shorter investigations, and traditionally managed directly by a program scientist as opposed to a program office such as ESSP. In 2010, ESSP crafted a management approach for the successful implementation of the EV-1 missions within the constructs of current governance models. NASA Research and Technology Program and Project Management Requirements form the foundation of the approach for EV-1. Additionally, requirements from other existing NASA Procedural Requirements (NPRs), systems engineering guidance and management handbooks were adapted to manage programmatic, technical, schedule, cost elements and risk. As the EV-1 missions are nearly at the end of their successful execution and project lifecycle and the submission deadline of the next mission proposals near, the ESSP PO is taking the lessons learned and updated the programmatic management approach for all future Earth Venture Suborbital (EVS) missions for an even more flexible and streamlined management approach.

  12. Management Approach for NASA's Earth Venture-1 (EV-1) Airborne Science Investigations

    Science.gov (United States)

    Guillory, Anthony R.; Denkins, Todd C.; Allen, B. Danette

    2013-01-01

    The Earth System Science Pathfinder (ESSP) Program Office (PO) is responsible for programmatic management of National Aeronautics and Space Administration's (NASA) Science Mission Directorate's (SMD) Earth Venture (EV) missions. EV is composed of both orbital and suborbital Earth science missions. The first of the Earth Venture missions is EV-1, which are Principal Investigator-led, temporally-sustained, suborbital (airborne) science investigations costcapped at $30M each over five years. Traditional orbital procedures, processes and standards used to manage previous ESSP missions, while effective, are disproportionally comprehensive for suborbital missions. Conversely, existing airborne practices are primarily intended for smaller, temporally shorter investigations, and traditionally managed directly by a program scientist as opposed to a program office such as ESSP. In 2010, ESSP crafted a management approach for the successful implementation of the EV-1 missions within the constructs of current governance models. NASA Research and Technology Program and Project Management Requirements form the foundation of the approach for EV-1. Additionally, requirements from other existing NASA Procedural Requirements (NPRs), systems engineering guidance and management handbooks were adapted to manage programmatic, technical, schedule, cost elements and risk. As the EV-1 missions are nearly at the end of their successful execution and project lifecycle and the submission deadline of the next mission proposals near, the ESSP PO is taking the lessons learned and updated the programmatic management approach for all future Earth Venture Suborbital (EVS) missions for an even more flexible and streamlined management approach.

  13. Energy spectrum of primary cosmic rays from 1016eV to 1019eV determined from air showers observed at 5200 m a.s.l

    International Nuclear Information System (INIS)

    Energy spectra of primary cosmic rays from 1016eV to 1019eV have been determined from electron-sizes as well as from muon-sizes of the same air showers observed at Mt. Chacaltaya. The spectrum from electron-sizes is significantly higher than that from muon-sizes. The discrepancy is discussed and an explanation is given under the assumption of possible existence of copious direct production of photons besides the production of charged and neutral pions at these high energies. The spectra are also compared with those by other groups and the discrepancies are discussed. (author)

  14. 解读肠病毒EV71——针对阜阳肠病毒EV71流行的答疑

    Institute of Scientific and Technical Information of China (English)

    王黎生

    2008-01-01

    @@ 新华社报道,阜阳市3月份以来发生小儿肠道病毒EV71疫情,数千儿童发病,22人经全力抢救无效死亡.消息传出,引起大众恐慌,咨询电话、短信不断:EV71到底是什么病毒?我们这里会不会发生?我们该怎么办?看来有必要做些答疑:

  15. 解读肠病毒EV71——针对阜阳肠病毒EV71流行的答疑

    Institute of Scientific and Technical Information of China (English)

    王黎生

    2008-01-01

    新华社报道,阜阳市3月份以来发生小儿肠道病毒EV71疫情,数千儿童发病,22人经全力抢救无效死亡。消息传出,引起大众恐慌,咨询电话、短信不断:EV71到底是什么病毒?我们这里会不会发生?我们该怎么办?看来有必要做些答疑:

  16. Analysis of EV71 infection progression using triple-SILAC-based proteomics approach.

    Science.gov (United States)

    Li, Hao-Yu; Zhang, Lei-Ke; Zhu, Xiu-Juan; Shang, Jun; Chen, Xi; Zhu, Ying; Guo, Lin

    2015-11-01

    Enterovirus 71 (EV71), a member of Picornaviridae, causes severe neurological and systemic illness in children. To better understand the virus-host cell interactions, we performed a triple-SILAC-based quantitative proteomics study monitoring host cell proteome changes after EV71 infection. Based on the quantitative data for more than 4100 proteins, ∼17% of the proteins were found as significantly changed (pEV71 replication. Further studies showed that CHCH2 served as a negative regulator of innate immune responses. All MS data have been deposited in the ProteomeXchange with identifier PXD002483 (http://proteomecentral.proteomexchange.org/dataset/PXD002483).

  17. EV Charging Analysis Based on the National Travel Surveys of the Nordic Area

    DEFF Research Database (Denmark)

    Liu, Zhaoxi; Wu, Qiuwei

    2014-01-01

    This paper presents the charging demand profiles of electric vehicles (EVs) based on the National Travel Surveys of the Nordic area. The EV charging analysis is carried out considering different types of charging patterns which are dumb charging, timed charging and spot price based charging....... The driving behavior of the vehicles is studied through the National Travel Surveys of Denmark, Finland, Norway and Sweden. The features of the charging demand are discussed based on the results of the analysis. The study in this paper provides an estimation of the possible level and patterns of the EV...... charging demand in the Nordic area....

  18. Asymptotic Normality of LS Estimate in Simple Linear EV Regression Model

    Institute of Scientific and Technical Information of China (English)

    Jixue LIU

    2006-01-01

    Though EV model is theoretically more appropriate for applications in which measurement errors exist, people are still more inclined to use the ordinary regression models and the traditional LS method owing to the difficulties of statistical inference and computation. So it is meaningful to study the performance of LS estimate in EV model.In this article we obtain general conditions guaranteeing the asymptotic normality of the estimates of regression coefficients in the linear EV model. It is noticeable that the result is in some way different from the corresponding result in the ordinary regression model.

  19. High Resolution Angle Resolved Photoemission with Tabletop 11eV Laser

    CERN Document Server

    He, Yu; Yi, Ming; Yang, Shuolong; Liu, Zhongkai; Lee, James; Chen, Sudi; Rebec, Slavko; Leuenberger, Dominik; Zong, Alfred; Jefferson, Michael; Moore, Robert; Kirchmann, Patrick; Merriam, Andrew; Shen, Zhixun

    2015-01-01

    We developed a table-top vacuum ultraviolet (VUV) laser with $113.778$nm wavelength (10.897eV) and demonstrated its viability as a photon source for high resolution angle-resolved photoemission spectroscopy (ARPES). This sub-nanosecond pulsed VUV laser operates at a repetition rate of 10MHz, provides a flux of 2$\\times$10$^{12}$ photons/second, and enables photoemission with energy and momentum resolutions better than 2meV and 0.012\\AA$^{-1}$, respectively. Space-charge induced energy shifts and spectral broadenings can be reduced below 2meV. The setup reaches electron momenta up to 1.2\\AA$^{-1}$, granting full access to the first Brillouin zone of most materials. Control over the linear polarization, repetition rate, and photon flux of the VUV source facilitates ARPES investigations of a broad range of quantum materials, bridging the application gap between contemporary low energy laser-based ARPES and synchrotron-based ARPES. We describe the principles and operational characteristics of this source, and sho...

  20. EV-13 Helium Valve Discharge Coefficient Characterization by Continuous Water Flow Test

    Science.gov (United States)

    Walker, Seth

    In this project, the students of the Suborbital Center of Excellence characterized the discharge coefficient of a modified NASA scientific Balloon valve using a water channel that was designed and built by the students specifically to test this valve. This coefficient is used in the balloon flight models (SINBAD) to predict the helium discharge rates at various altitudes and appropriate helium vent durations. Previous phases of the project subjected the valve to both highly transient and steady air flows resulting in a relatively small range of possible discharge coeffi- cient values that compared well to previous tests of the EV-13 valve. In this test, water is to be used as the working fluid because there will be fewer variables in the equation. Fewer equation variables translate to an error rate smaller than some of the previous test phases. Additionally, the authors present a detailed error/uncertainty analysis, description of the test setup, experimental procedures, calculations, results from previous phases, and literature searches.

  1. Search for eV sterile neutrinos at a nuclear reactor — the Stereo project

    Science.gov (United States)

    Haser, J.; Stereo Collaboration

    2016-05-01

    The re-analyses of the reference spectra of reactor antineutrinos together with a revised neutrino interaction cross section enlarged the absolute normalization of the predicted neutrino flux. The tension between previous reactor measurements and the new prediction is significant at 2.7 σ and is known as “reactor antineutrino anomaly”. In combination with other anomalies encountered in neutrino oscillation measurements, this observation revived speculations about the existence of a sterile neutrino in the eV mass range. Mixing of this light sterile neutrino with the active flavours would lead to a modification of the detected antineutrino flux. An oscillation pattern in energy and space could be resolved by a detector at a distance of few meters from a reactor core: the neutrino detector of the Stereo project will be located at about 10 m distance from the ILL research reactor in Grenoble, France. Lengthwise separated in six target cells filled with 2 m3 Gd-loaded liquid scintillator in total, the experiment will search for a position-dependent distortion in the energy spectrum.

  2. Invited Article: High resolution angle resolved photoemission with tabletop 11 eV laser

    Energy Technology Data Exchange (ETDEWEB)

    He, Yu; Vishik, Inna M.; Yi, Ming; Yang, Shuolong; Lee, James J.; Chen, Sudi; Rebec, Slavko N.; Leuenberger, Dominik; Shen, Zhi-Xun [SIMES, SLAC National Accelerator Laboratory, Menlo Park, California 94025 (United States); Department of Applied Physics, Stanford University, Stanford, California 94305 (United States); Liu, Zhongkai [SIMES, SLAC National Accelerator Laboratory, Menlo Park, California 94025 (United States); Department of Physics, Stanford University, Stanford, California 94305 (United States); Zong, Alfred [Department of Physics, Stanford University, Stanford, California 94305 (United States); Jefferson, C. Michael; Merriam, Andrew J. [Lumeras LLC, 207 McPherson St, Santa Cruz, California 95060 (United States); Moore, Robert G.; Kirchmann, Patrick S. [SIMES, SLAC National Accelerator Laboratory, Menlo Park, California 94025 (United States)

    2016-01-15

    We developed a table-top vacuum ultraviolet (VUV) laser with 113.778 nm wavelength (10.897 eV) and demonstrated its viability as a photon source for high resolution angle-resolved photoemission spectroscopy (ARPES). This sub-nanosecond pulsed VUV laser operates at a repetition rate of 10 MHz, provides a flux of 2 × 10{sup 12} photons/s, and enables photoemission with energy and momentum resolutions better than 2 meV and 0.012 Å{sup −1}, respectively. Space-charge induced energy shifts and spectral broadenings can be reduced below 2 meV. The setup reaches electron momenta up to 1.2 Å{sup −1}, granting full access to the first Brillouin zone of most materials. Control over the linear polarization, repetition rate, and photon flux of the VUV source facilitates ARPES investigations of a broad range of quantum materials, bridging the application gap between contemporary low energy laser-based ARPES and synchrotron-based ARPES. We describe the principles and operational characteristics of this source and showcase its performance for rare earth metal tritellurides, high temperature cuprate superconductors, and iron-based superconductors.

  3. Invited Article: High resolution angle resolved photoemission with tabletop 11 eV laser.

    Science.gov (United States)

    He, Yu; Vishik, Inna M; Yi, Ming; Yang, Shuolong; Liu, Zhongkai; Lee, James J; Chen, Sudi; Rebec, Slavko N; Leuenberger, Dominik; Zong, Alfred; Jefferson, C Michael; Moore, Robert G; Kirchmann, Patrick S; Merriam, Andrew J; Shen, Zhi-Xun

    2016-01-01

    We developed a table-top vacuum ultraviolet (VUV) laser with 113.778 nm wavelength (10.897 eV) and demonstrated its viability as a photon source for high resolution angle-resolved photoemission spectroscopy (ARPES). This sub-nanosecond pulsed VUV laser operates at a repetition rate of 10 MHz, provides a flux of 2 × 10(12) photons/s, and enables photoemission with energy and momentum resolutions better than 2 meV and 0.012 Å(-1), respectively. Space-charge induced energy shifts and spectral broadenings can be reduced below 2 meV. The setup reaches electron momenta up to 1.2 Å(-1), granting full access to the first Brillouin zone of most materials. Control over the linear polarization, repetition rate, and photon flux of the VUV source facilitates ARPES investigations of a broad range of quantum materials, bridging the application gap between contemporary low energy laser-based ARPES and synchrotron-based ARPES. We describe the principles and operational characteristics of this source and showcase its performance for rare earth metal tritellurides, high temperature cuprate superconductors, and iron-based superconductors. PMID:26827301

  4. 1-eV GaInNAs solar cells for ultrahigh-frequency multijunction devices

    Energy Technology Data Exchange (ETDEWEB)

    Friedman, D.J.; Geisz, J.F.; Kurtz, S.R.; Olson, J.M. [National Renewable Energy Lab., Golden, CO (United States)

    1998-09-01

    The authors demonstrate working prototypes of a GaInNAs-based solar cell lattice-matched to GaAs with photoresponse down to 1 eV. This device is intended for use as the third junction of future-generation ultrahigh-efficiency three- and four-junction devices. Under the AM1.5 direct spectrum with all the light higher in energy than the GaAs band gap filtered out, the prototypes have open-circuit voltages ranging from 0.35 to 0.44 V, short-circuit currents of 1.8 mA/cm{sup 2}, and fill factors from 61--66%. The short-circuit currents are of principal concern: the internal quantum efficiencies rise only to about 0.2. The authors discuss the short diffusion lengths which are the reason for this low photocurrent. As a partial workaround for the poor diffusion lengths, they demonstrate a depletion-width-enhanced variation of one of the prototype devices that grades off decreased voltage for increased photocurrent, with a short-circuit current of 6.5 mA/cm{sup 2} and an open-circuit voltage of 0.29 V.

  5. EvArnoldi: A New Algorithm for Large-Scale Eigenvalue Problems.

    Science.gov (United States)

    Tal-Ezer, Hillel

    2016-05-19

    Eigenvalues and eigenvectors are an essential theme in numerical linear algebra. Their study is mainly motivated by their high importance in a wide range of applications. Knowledge of eigenvalues is essential in quantum molecular science. Solutions of the Schrödinger equation for the electrons composing the molecule are the basis of electronic structure theory. Electronic eigenvalues compose the potential energy surfaces for nuclear motion. The eigenvectors allow calculation of diople transition matrix elements, the core of spectroscopy. The vibrational dynamics molecule also requires knowledge of the eigenvalues of the vibrational Hamiltonian. Typically in these problems, the dimension of Hilbert space is huge. Practically, only a small subset of eigenvalues is required. In this paper, we present a highly efficient algorithm, named EvArnoldi, for solving the large-scale eigenvalues problem. The algorithm, in its basic formulation, is mathematically equivalent to ARPACK ( Sorensen , D. C. Implicitly Restarted Arnoldi/Lanczos Methods for Large Scale Eigenvalue Calculations ; Springer , 1997 ; Lehoucq , R. B. ; Sorensen , D. C. SIAM Journal on Matrix Analysis and Applications 1996 , 17 , 789 ; Calvetti , D. ; Reichel , L. ; Sorensen , D. C. Electronic Transactions on Numerical Analysis 1994 , 2 , 21 ) (or Eigs of Matlab) but significantly simpler. PMID:27015379

  6. Analysis of cross-reactive neutralizing antibodies in human HFMD serum with an EV71 pseudovirus-based assay.

    Science.gov (United States)

    Zhang, Huafei; An, Dong; Liu, Wei; Mao, Qunying; Jin, Jun; Xu, Lin; Sun, Shiyang; Jiang, Liping; Li, Xiaojun; Shao, Jie; Ma, Hongxia; Huang, Xueyong; Guo, Shijie; Chen, Haiying; Cheng, Tong; Yang, Lisheng; Su, Weiheng; Kong, Wei; Liang, Zhenglun; Jiang, Chunlai

    2014-01-01

    Hand, foot and mouth disease, associated with enterovirus 71 (EV71) infections, has recently become an important public health issue throughout the world. Serum neutralizing antibodies are major indicators of EV71 infection and protective immunity. However, the potential for cross-reactivity of neutralizing antibodies for different EV71 genotypes and subgenotypes is unclear. Here we measured the cross-reactive neutralizing antibody titers against EV71 of different genotypes or subgenotypes in sera collected from EV71-infected children and vaccine-inoculated children in a phase III clinical trial (ClinicalTrials.gov Identifier: NCT01636245) using a new pseudovirus-based neutralization assay. Antibodies induced by EV71-C4a were cross-reactive for different EV71 genotypes, demonstrating that C4a is a good candidate strain for an EV71 vaccine. Our study also demonstrated that this new assay is practical for analyses of clinical samples from epidemiological and vaccine studies.

  7. A preliminary report on x-ray photoabsorption coefficients and atomic scattering factors for 92 elements in the 10--10,000 eV region

    International Nuclear Information System (INIS)

    Based on currently available photoabsorption measurements and recent theoretical calculations by Doolen and Liberman, a revised best-fit determination of the photoabsorption cross sections is presented here for the elements Z = 1 to Z = 92 in the 10--10,000 eV range. The photoabsorption data used include those described in the Lockheed and DOE listings of research abstracts for the past ten years and those which have been recently added to the comprehensive NBS Measured data Base. The best-fit curves are compared with both the compilation of measurements and the calculations by Doolen and Liberman. Using the photoabsorption curves, the atomic scattering factors have been calculated for the energy range 50--10,000 eV and are also presented in this report

  8. Kaks nooremat luuletajat : Bernard Kangro "Vanad majad" ja Heiti Talviku "Kohtupäev" / Ants Oras

    Index Scriptorium Estoniae

    Oras, Ants

    2004-01-01

    Arvustus: Kangro, Bernard. Vanad majad : luuletusi 1936-37. Tartu : Eesti Kirjanikkude Liit, 1937 ; Talvik, Heiti. Kohtupäev. Tartu : Eesti Kirjanikkude Liit, 1937. Varem ilmunud: Eesti Kirjandus, 1937, nr. 12, lk. 618-622

  9. space pattern of events with halo in the field of energies E≥1015 eV

    International Nuclear Information System (INIS)

    In Roentgen emulsion chamber of 'Adron-44' facility located at 3340 m, we have registered two exotic interactions with build-up of halo- diffuse dark spots several cm2 in size in the area of energy > 1015 eV. Similar events were registered in rock experiments of some foreign teams (Japan-Brazil collaboration, 'Pamir' cooperation etc.). Nature of halo build-up is not clear enough even now, that is why detailed study of this phenomena is of great interest. In the report there are space and energy parameters of secondary gamma-quanta building halo in events with E = 4.4·101'5 eV and 3.3·1015 eV. Space distribution is compared with calculated distributions basing on scaling model. The comparison helps to conclude that there is possible scaling failure in the field of fragmentation of impinging hadron at E0∼1016 eV

  10. EV71 vaccines: a first step towards multivalent hand, foot and mouth disease vaccines.

    Science.gov (United States)

    Klein, Michel H

    2015-03-01

    Enterovirus A infections are the primary cause of hand, foot and mouth disease in infants and young children. Enterovirus 71 (EV71) and coxsackievirus A16 have emerged as neurotropic viruses responsible for severe neurological complications and a serious public health threat across the Asia-Pacific region. Formalin-inactivated EV71 vaccines have elicited protection against EV71 but not against coxsackievirus A16 infections. The development of a bivalent formalin-inactivated EV71/FI coxsackievirus A16 vaccine should be the next step towards that of multivalent hand, foot and mouth disease vaccines which should ultimately include other prevalent pathogenic coxsackieviruses and echovirus 30. This editorial summarizes the major challenges faced by the development of hand, foot and mouth disease vaccines.

  11. UNITI Bundesverband mittelstaendischer Mineraloelunternehmen e.V.. Annual report 2011/2012; UNITI Bundesverband mittelstaendischer Mineraloelunternehmen e.V.. Jahresbericht 2011/2012

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2012-07-01

    The report presents the organisational structure and activities of the UNITI Bundesverband mittelstaendischer Mineraloelunternehmen e.V. (Berlin, Federal Republic of Germany). Above all, topical issues on business in the mineral oil and lubricant sector are discussed. There is an appendix containing data on the production and sales of petroleum products in the Federal Republic of Germany.

  12. Fachagentur Nachwachsende Rohstoffe e.V. Annual report 2011/2012; Fachagentur Nachwachsende Rohstoffe e.V. (FNR). Jahresbericht 2011/2012

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2012-07-01

    The annual report of the Fachagentur Nachwachsende Rohstoffe e.V. (Guelzow-Pruezen, Federal Republic of Germany) outlines the cultivation of industrial crops and energy plants in Germany. The organisational structure of the association and its research projects are presented for the fiscal year 2011/2012.

  13. Establishment of EV71 animal models with 2-week-old BALB/c mice%应用2周龄BALB/c小鼠建立EV71动物模型

    Institute of Scientific and Technical Information of China (English)

    王辉强; 蒋建东; 李玉环

    2013-01-01

    动物模型对于抗EV71药物和疫苗的研发非常重要.我国目前的EV 71小鼠模型大多采用1日龄乳鼠,因年龄太小进行抗病毒实验操作难度较大,给药途径和给药容量明显受限.在12~14日龄乳鼠上连续5代适应EV71毒株,成功建立了2周龄BALB/c小鼠的EV71模型,并且采用细胞病变(CPE)法滴定了小鼠心、肝、脾、肺、肾、小肠、脑和肌肉组织的EV 71病毒滴度.该模型采用的EV71病毒株是我国最早分离到的病毒株,动物采用的是2周龄的小鼠,对我国目前建立的EV71动物模型是个补充,可以更好地服务于我国抗EV71药物和疫苗的研发.%Animal model is very important for anti-EV71 (enterovirus 71) drug and vaccine development. 1-day-old suckling EV71 mouse model is the main in vivo model used in China. 1-day-old suckling EV71 mouse is too small to perform antiviral experiment. And the route of administration and dosage capacity are also restricted. A strong virulence EV71 virus strain was selected after screening from five EV71 strains with 1-day-old suckling mice. A mouse-adapted EV71 strain with increased virulence in 12-day-old suckling mice, EV71-M5, was generated after five serial passages of the parental EV71 strain in mice. Virus titers of EV71 infected mice heart, liver, spleen, lung, kidney, small intestine, brain and muscle tissue were determined by cytopathic effect (CPE) assay. The virus used in this model is the first isolated EV71 strain in China. And 2-week-old suckling mice were used in this model. This is a supplement for the EV71 animal model in China. Establishment of this EV71 model will provide an attractive platform for anti-EV71 vaccine and drug development.

  14. Compact focusing spectrometer: Visible (1 eV) to hard x-rays (200 keV)

    Science.gov (United States)

    Baronova, E. O.; Stepanenko, A. M.; Pereira, N. R.

    2014-11-01

    A low-cost spectrometer that covers a wide range of photon energies can be useful to teach spectroscopy, and for simple, rapid measurements of the photon spectrum produced by small plasma devices. The spectrometer here achieves its wide range, nominally from 1 eV to 200 keV, with a series of spherically and cylindrically bent gratings or crystals that all have the same shape and the same radius of curvature; they are complemented by matching apertures and diagnostics on the Rowland circle that serves as the circular part of the spectrometer's vacuum vessel. Spectral lines are easily identified with software that finds their positions from the dispersion of each diffractive element and the known energies of the lines.

  15. 警惕肠道病毒EV71感染危害儿童

    Institute of Scientific and Technical Information of China (English)

    谷峰

    2008-01-01

    @@ 肠道病毒EV71感染疾病是由肠道病毒EV71引起的一种传染病,一年四季都可发生,但多发生于4~9月份.该病是全球性传染病,世界大部分地区均有此病流行的报道.

  16. Anion Mass Spectrometry Study of Ion-Pair Photodissociation of CO2 in the XUV Energy 19.70-22.24 eV

    Institute of Scientific and Technical Information of China (English)

    FENG Qiang; TIAN Shan-Xi; ZHAO Yu-Jie; LIU Fu-Yi; SHAN Xiao-Bin; SHENG Liu-Si

    2009-01-01

    We demonstrate anion mass spectrometry using the Hefei synchrotron radiation source to investigate the ion-pair dissociation processes of molecules. The efficiency curve of the O- anionic product via ion-pair dissociations of CO2 is recorded with tunable extreme vacuum ultraviolet photons (energy: 19. 70-22.24 eV) and compared with the spectrum available in the literature. The possible dynamics of CO2 + hv → CO+ + O- in this energy range is discussed.

  17. Fluorescence Detection of Cosmic Ray Air Showers between 10^16.5 eV and 10^19 eV with the Telescope Array Low Energy Extension (TALE)

    Science.gov (United States)

    Matthews, J. N.; Zundel, Z.; Jui, C. C. H.; Smith, J. D.; Thomas, S. B.; Ivanov, D.

    2013-04-01

    The Telescope Array Experiment has been observing cosmic ray air showers at energies above 10^18 eV since 2008. TA operates three Fluorescence Detector (FD) sites, with telescopes that observe 3-31 deg in elevation. The FD sites are located at the periphery of a surface array of 507 scintillation counters covering 700 km^2, with 1.2km spacing. The TA Collaboration is in the process of building a low-energy extension at its Middle drum FD site. Ten new telescopes will observe between 33 and 51 degrees in elevation. A graded ground array of between 400 and 600m will be placed in front of the TALE FD. We have already observed multi-telescope cosmic ray events as well as the scattered light from the central laser (CLF). By 4/2013, all ten telescopes will have been commissioned and the first 35 scintillator counters will have been deployment by helicopter. With these upgrades, the physics threshold of TA will be lowered to 10^16.5 eV. The TA Low Energy Extension (TALE) will explore the energy regime corresponding to that of the LHC in center-of-mass frame. This is also the range where the transition from galactic to extra- galactic cosmic ray flux is suspected to occur. We will give a brief overview of the physics, and report on the progress of TALE.

  18. Complete Genome Analysis of an Enterovirus EV-B83 Isolated in China.

    Science.gov (United States)

    Tang, Jingjing; Li, Qiongfen; Tian, Bingjun; Zhang, Jie; Li, Kai; Ding, Zhengrong; Lu, Lin

    2016-01-01

    Enterovirus B83 (EV-B83) is a recently identified member of enterovirus species B. It is a rarely reported serotype and up to date, only the complete genome sequence of the prototype strain from the United States is available. In this study, we describe the complete genomic characterization of an EV-B83 strain 246/YN/CHN/08HC isolated from a healthy child living in border region of Yunnan Province, China in 2008. Compared with the prototype strain, it had 79.6% similarity in the complete genome and 78.9% similarity in the VP1 coding region, reflecting the great genetic divergence among them. VP1-coding region alignment revealed it had 77.2-91.3% with other EV-B83 sequences available in GenBank. Similarity plot analysis revealed it had higher identity with several other EV-B serotypes than the EV-B83 prototype strain in the P2 and P3 coding region, suggesting multiple recombination events might have occurred. The great genetic divergence with previously isolated strains and the extremely rare isolation suggest this serotype has circulated at a low epidemic strength for many years. This is the first report of complete genome of EV-B83 in China. PMID:27405393

  19. miR-27a suppresses EV71 replication by directly targeting EGFR.

    Science.gov (United States)

    Zhang, Lianglu; Chen, Xiong; Shi, Yingying; Zhou, Bingfei; Du, Chen; Liu, Yongjuan; Han, Song; Yin, Jun; Peng, Biwen; He, Xiaohua; Liu, Wanhong

    2014-12-01

    Enterovirus 71 (EV71), a major causative agent of hand, foot, and mouth disease, has broken out several times and was accompanied by neurological disease. microRNAs, a class of small non-coding RNAs that are approximately 20 nucleotides long, play important roles in the regulation of various biological processes, including antiviral defense. However, the roles of miRNAs in EV71 replication and pathogenesis are not well understood. In this study, we found that the expression of miR-27a was significantly decreased in EV71-infected cells. Interestingly, the over-expression of miR-27a could inhibit EV71 replication, as measured by virus titration, qPCR, and Western blotting. We identified EGFR mRNA is a bona fide target of miR-27a by computational analysis and luciferase reporter assays. Furthermore, miR-27a could decrease EGFR expression, as measured by qPCR and Western blotting. Moreover, the inhibition of EGFR expression by miR-27a decreased the phosphorylation of Akt and ERK, which facilitate EV71 replication. These results suggest that miR-27a may have antiviral activity against EV71 by inhibiting EGFR.

  20. Two models for changes of EV71 immunity in infants and young children.

    Science.gov (United States)

    Tu, Xiaoming; Wang, Yongmei; Zhu, Fengcai; Chen, Feng

    2015-01-01

    Human enterovirus 71 (EV71) has been associated with outbreaks of hand-foot-and-mouth disease (HFMD) in China. Susceptibility to EV71 is associated with age, but few studies have been accomplished to measure such a relationship. A better understanding of the connection between susceptibility and age is necessary to develop strategies for control of HFMD. In 2010, a survey of an epidemic of EV71 was conducted in a northern city of Jiangsu Province in China. Samples were tested serologically to identify the EV71 neutralizing antibody. Two different mathematical models have now been employed to describe how this antibody varied with age, and parameters in the model were estimated from survey data. Both models depicted the variations in EV71-neutralizing antibody. Seroprevalence was high for neonates but decreased to near zero at 5 months of age. Subsequently, the EV71 antibody levels increased and then remained stable after about 36 months. For models 1 and 2, values for the coefficient of determination (R(2)) were 0.9458 and 0.9576, and values for root mean square error (RMSE) were 0.0755 and 0.0752, respectively. Model 2, formulated from the characteristics of development of the immune system, was more reliable than model 1, formulated from survey data, because the impact of the survey on the structure of the model was removed. Moreover, model 2 provided the possibility to define the parameters in a biological sense.

  1. A modification potential method of calculating total cross sections of electrons scattering from complex molecules C2H6, C2F6, C6H6 and C6F6 at 100 eV-5000 eV

    Institute of Scientific and Technical Information of China (English)

    Shi De-Heng; Sun Jin-Feng; Zhu Zun-Lue; Liu Yu-Fang; Yang Xiang-Dong

    2006-01-01

    A complex optical model potential modified by incorporating the concept of bonded atom, which takes into consideration the overlapping effect of electron clouds between two atoms in a molecule, is first employed to calculate the total cross sections for electrons scattering from such complex molecules as C2H6, C2F6, C6H6 and C6F6 using the additivity rule model at Hartree-Fock level over the energy range from 100 eV to 5000 eV. The total cross sections are quantitatively compared with those obtained by experiments wherever available, and they are in good agreement with each other over a wide energy range. It is shown that the modified potential together with the additivity rule model is completely suitable for the calculation of total cross sections of electrons scattering from such complex molecules as C2H6, C2F6, C6H6 and C6F6 above 200 eV-300 eV.

  2. Transfer Excitation Processes Observed in N3+-He and O3+-He Collisions at Elab = 33 eV

    Science.gov (United States)

    Itoh, Yoh

    2016-09-01

    We measured the relative state-selective differential cross sections (DCSs) for one-electron capture reactions using a crossed-beam apparatus. The scattering angle θlab studied in the laboratory frame ranged from -3.0 to 22° and the laboratory collision energy Elab was 33 eV. Only the transfer excitation processes, i.e., the electron capture reactions with the simultaneous excitation of the projectile, were observed. The DCSs were determined for the following reactions: N3+ (1s2 2s2 1S) + He (1s2 1S) → N2+ (1s2 2s2p2 2D) + He+ (1s 2S) + 10.3 eV, O3+ (1s2 2s2 2p 2P) + He (1s2 1S) → O2+ (1s2 2s 2p3 3P) + He+ (1s 2S) + 12.7 eV, and O3+ (1s2 2s2 2p 2P) + He (1s2 1S) → O2+ (1s2 2s 2p3 3D) + He+ (1s 2S) + 15.5 eV. In the N3+-He system, the DCSs for the reaction are zero at the center-of-mass angle θcm = 0 and show a peak at a certain angle and a shoulder at a larger angle. In the O3+-He system, the DCSs are again zero at θcm = 0. The capture process to the O2+ (1s2 2s 2p3 3P) state is mainly observed at smaller scattering angles, and the reaction to the O2+ (1s2 2s 2p3 3D) state becomes dominant with increasing scattering angle. A classical trajectory analysis within the two-state approximation based on the ab initio potentials for (NHe)3+ revealed that the transfer excitation of a two-electron process takes place through a single crossing of the relevant potentials.

  3. Identification of specific antigenic epitope at N-terminal segment of enterovirus 71 (EV-71) VP1 protein and characterization of its use in recombinant form for early diagnosis of EV-71 infection

    OpenAIRE

    Zhang, Jianhua; Jiang, Bingfu; Xu, Mingjie; Dai, Xing; Purdy, Michael A.; Meng, Jihong

    2014-01-01

    Human enterovirus 71 (EV-71) is the main etiologic agent of hand, foot and mouth disease (HFMD). We sought to identify EV-71 specific antigens and develop serologic assays for acute-phase EV-71 infection. A series of truncated proteins within the N-terminal 100 amino acids (aa) of EV-71 VP1 was expressed in Escherichia coli. Western blot (WB) analysis showed that positions around 11–21 aa contain EV-71-specific antigenic sites, whereas positions 1–5 and 51–100 contain epitopes shared with hum...

  4. Commercial Electric Vehicle (EV) Development and Manufacturing Program

    Energy Technology Data Exchange (ETDEWEB)

    Leeve, Dion

    2014-06-30

    Navistar with the Department of Energy’s assistance undertook this effort to achieve the project objectives as listed in the next section. A wholly owned subsidiary of Navistar, Workhorse Sales Corporation was the original grant awardee and upon their discontinuation as a standalone business entity, Navistar assumed the role of principal investigator. The intent of the effort, as part of the American Recovery and Reinvestment Act (ARRA) was to produce zero emission vehicles that could meet the needs of the marketplace while reducing carbon emissions to zero. This effort was predicated upon the assumption that concurrent development activities in the lithium ion battery industry investigations would significantly increase their production volumes thus leading to substantial reductions in their manufacturing costs. As a result of this development effort much was learned about the overall system compatibility between the electric motor, battery pack, and charging capabilities. The original system was significantly revised and improved during the execution of this development effort. The overall approach that was chosen was to utilize a British zero emissions, class 2 truck that had been developed for their market, homologate it and modify it to meet the product requirements as specified in the grant details. All of these specific goals were achieved. During the course of marketing and selling the product valuable information was obtained as relates to customer expectations, price points, and product performance expectations, specifically those customer expectations about range requirements in urban delivery situations. While the grant requirements specified a range of 100 miles on a single charge, actual customer usage logs indicate a range of 40 miles or less is typical for their applications. The price point, primarily due to battery pack costs, was significantly higher than the mass market could bear. From Navistar’s and the overall industry’s perspective

  5. Energy deposition model for low-energy electrons (10-10 000 eV) in air

    International Nuclear Information System (INIS)

    An energy deposition model for electrons in air that can be useful in microdosimetric applications is presented in this study. The model is based on a Monte Carlo simulation of the single electron scattering processes that can take place with the molecular constituents of the air in the energy range 10-10 000 eV. The input parameters for this procedure have been the electron scattering cross sections, both differential and integral. These parameters were calculated using a model potential method which describes the electron scattering with the molecular constituent of air. The reliability of the calculated integral cross section values has been evaluated by comparison with direct total electron scattering cross-section measurements performed by us in a transmission beam experiment. Experimental energy loss spectra for electrons in air have been used as probability distribution functions to define the electron energy loss in single collision events. The resulting model has been applied to simulate the electron transport through a gas cell containing air at different pressures and the results have been compared with those observed in the experiments. Finally, as an example of its applicability to dosimetric issues, the energy deposition of 10 000 eV by means of successive collisions in a free air chamber has been simulated

  6. Electron Impact Ionization: A New Parameterization for 100 eV to 1 MeV Electrons

    Science.gov (United States)

    Fang, Xiaohua; Randall, Cora E.; Lummerzheim, Dirk; Solomon, Stanley C.; Mills, Michael J.; Marsh, Daniel; Jackman, Charles H.; Wang, Wenbin; Lu, Gang

    2008-01-01

    Low, medium and high energy electrons can penetrate to the thermosphere (90-400 km; 55-240 miles) and mesosphere (50-90 km; 30-55 miles). These precipitating electrons ionize that region of the atmosphere, creating positively charged atoms and molecules and knocking off other negatively charged electrons. The precipitating electrons also create nitrogen-containing compounds along with other constituents. Since the electron precipitation amounts change within minutes, it is necessary to have a rapid method of computing the ionization and production of nitrogen-containing compounds for inclusion in computationally-demanding global models. A new methodology has been developed, which has parameterized a more detailed model computation of the ionizing impact of precipitating electrons over the very large range of 100 eV up to 1,000,000 eV. This new parameterization method is more accurate than a previous parameterization scheme, when compared with the more detailed model computation. Global models at the National Center for Atmospheric Research will use this new parameterization method in the near future.

  7. Demonstration experiment of a laser synchrotron source for tunable, monochromatic x-rays at 500 eV

    Energy Technology Data Exchange (ETDEWEB)

    Ting, A.; Fischer, R.; Fisher, A. [Naval Research Lab., Washington, DC (United States)] [and others

    1995-12-31

    A Laser Synchrotron Source (LSS) was proposed to generate short-pulsed, tunable x-rays by Thomson scattering of laser photons from a relativistic electron beam. A proof-of-principle experiment was performed to generate x-ray photons of 20 eV. A demonstration experiment is being planned and constructed to generate x-ray photons in the range of {approximately}500 eV. Laser photons of {lambda}=1.06 {mu}m are Thomson backscattered by a 4.5 MeV electron beam which is produced by an S-band RF electron gun. The laser photons are derived from either (i) a 15 Joules, 3 nsec Nd:glass laser, (ii) the uncompressed nsec: pulse of the NRL table-top terawatt (T{sup 3}) laser, or (iii) the compressed sub-picosec pulse of the T{sup 3} laser. The RF electron gun is being constructed with initial operation using a thermionic cathode. It will be upgraded to a photocathode to produce high quality electron beams with high current and low emittance. The x-ray pulse structure consists of {approximately}10 psec within an envelope of a macropulse whose length depends on the laser used. The estimated x-ray photon flux is {approximately}10{sup 18} photons/sec, and the number of photons per macropulse is {approximately}10{sup 8}. Design parameters and progress of the experiment will be presented.

  8. A new Scanning Transmission X-ray Microscope at the ALS for operation up to 2500eV

    Energy Technology Data Exchange (ETDEWEB)

    Kilcoyne, David; Ade, Harald; Attwood, David; Hitchcock, Adam; McKean, Pat; Mitchell, Gary; Monteiro, Paulo; Tyliszczak, Tolek; Warwick, Tony

    2010-01-31

    We report on the design and construction of a higher energy Scanning Transmission X-ray Microscope on a new bend magnet beam line at the Advanced Light Source. Previously we have operated such an instrument on a bend magnet for C, N and O 1s NEXAFS spectroscopy. The new instrument will have similar performance at higher energies up to and including the S 1s edge at 2472eV. A new microscope configuration is planned. A more open geometry will allow a fluorescence detector to count emitted photons from the front surface of the sample. There will be a capability for zone plate scanning in addition to the more conventional sample scanning mode. This will add the capability for imaging a massive sample at high resolution over a limited field of view, so that heavy reaction cells may be used to study processes in-situ, exploiting the longer photon attenuation length and the longer zone plate working distances available at higher photon energy. The energy range will extend down to include the C1s edge at 300eV, to allow high energy NEXAFS microscopic studies to correlate with the imaging of organics in the same sample region of interest.

  9. Photoionization of iodine atoms: Angular distributions and relative partial photoionization cross-sections in the energy region 11.0-23.0 eV

    Science.gov (United States)

    Eypper, Marie; Innocenti, Fabrizio; Morris, Alan; Dyke, John M.; Stranges, Stefano; West, John B.; King, George C.

    2010-08-01

    Relative partial photoionization cross-sections and angular distribution parameters, β, have been measured for the first, I+(P32)←I(P23/2), and fourth, I+(D12)←I(P23/2), (5p)-1 photoelectron (PE) bands of atomic iodine, by performing angle-resolved constant-ionic-state (CIS) measurements on these PE bands in the photon energy range 11.0-23.0 eV. Three Rydberg series, two ns and one nd series, which converge to the I+ P31 limit at 11.33 eV and four Rydberg series, two ns and two nd series, which converge to the I+ D12 limit at 12.15 eV were observed in the first PE band CIS spectra. The fourth band CIS spectrum showed structure in the 12.9-14.1eV photon energy range, which is also seen in the first band CIS spectra. This structure arises from excitation to ns and nd Rydberg states that are parts of series converging to the I+ S10 limit we reported on earlier, as well as 5s→5p excitations in the photon energy range 17.5-22.5 eV. These atomic iodine CIS spectra show reasonably good agreement with the equivalent spectra obtained for atomic bromine. The β-plots for the first PE band recorded up to the I+ P31 and I+ D12 limits only show resonances corresponding to some of the 5p→nd excitations observed in the first band CIS spectra scanned to the I+ D12 limit (12.15 eV). These plots are interpreted in terms of an angular momentum transfer model with the positive values of β obtained on resonances corresponding to parity allowed jt=1 and 3 channels and the off-resonance negative β values corresponding to parity unfavored channels, where jt is the quantum number for angular momentum transfer between the molecule, and the ion and photoelectron. The β-plots recorded for iodine are significantly different from those obtained for atomic bromine. Comparison of the experimental CIS spectra and β-plots with available theoretical results highlights the need for higher level calculations which include factors such as configuration interaction in the initial and final

  10. A new treatment for neurogenic inflammation caused by EV71 with CR2-targeted complement inhibitor

    Directory of Open Access Journals (Sweden)

    Qiu Shaofu

    2012-11-01

    Full Text Available Abstract Background Enterovirus 71 (EV71, one of the most important neurotropic EVs, has caused death and long-term neurological sequelae in hundreds of thousands of young children in the Asia-Pacific region in the past decade. The neurological diseases are attributed to infection by EV71 inducing an extensive peripheral and central nervous system (CNS inflammatory response with abnormal cytokine production and lymphocyte depletion induced by EV71 infection. In the absence of specific antiviral agents or vaccines, an effective immunosuppressive strategy would be valuable to alleviate the severity of the local inflammation induced by EV71 infection. Presentation of the hypothesis The complement system plays a pivotal role in the inflammatory response. Inappropriate or excessive activation of the complement system results in a severe inflammatory reaction or numerous pathological injuries. Previous studies have revealed that EV71 infection can induce complement activation and an inflammatory response of the CNS. CR2-targeted complement inhibition has been proved to be a potential therapeutic strategy for many diseases, such as influenza virus-induced lung tissue injury, postischemic cerebral injury and spinal cord injury. In this paper, a mouse model is proposed to test whether a recombinant fusion protein consisting of CR2 and a region of Crry (CR2-Crry is able to specifically inhibit the local complement activation induced by EV71 infection, and to observe whether this treatment strategy can alleviate or even cure the neurogenic inflammation. Testing the hypothesis CR2-Crry is expressed in CHO cells, and its biological activity is determined by complement inhibition assays. 7-day-old ICR mice are inoculated intracranially with EV71 to duplicate the neurological symptoms. The mice are then divided into two groups, in one of which the mice are treated with CR2-Crry targeted complement inhibitor, and in the other with phosphate-buffered saline. A

  11. 武汉地区2011年553例手足口病患儿EV71-IgMELISA法和EV71RNART-PCR法检测结果分析

    Institute of Scientific and Technical Information of China (English)

    李虹泽; 项杰

    2012-01-01

    目的 对EV71-IgM ELISA法和EV71 RNA RT-PCR法检测肠道病毒71型进行比较.方法 采用EV71-IgM ELISA法和EV71 RNA RT-PCR法分别对553例手足口病临床确诊患儿的静脉血和咽拭标本进行检测.结果 EV71-IgM ELISA法阳性率35.62%(197例)高于EV71 RNA RT-PCR法阳性率18.63%(103例),差异存在统计学意义(χ2=39.56,P<0.001).EV71-IgM ELISA(-)且EV71 RNA RT-PCR(-)有329例,同时EV71-IgM ELISA(-)且EV71 RNA RT-PCR(+)有24例,进一步表明两种方法 结果 之间的差异存在统计学意义(χ2=63.11,P<0.001).结论 EV71-IgM ELISA法具有高敏感性,操作简单,成本低,适用范围广等优点.

  12. The size and range effect: lifecycle greenhouse gas emissions of electric vehicles

    Science.gov (United States)

    Ager-Wick Ellingsen, Linda; Singh, Bhawna; Hammer Strømman, Anders

    2016-05-01

    The primary goal of this study is to investigate the effect of increasing battery size and driving range to the environmental impact of electric vehicles (EVs). To this end, we compile cradle-to-grave inventories for EVs in four size segments to determine their climate change potential. A second objective is to compare the lifecycle emissions of EVs to those of conventional vehicles. For this purpose, we collect lifecycle emissions for conventional vehicles reported by automobile manufacturers. The lifecycle greenhouse gas emissions are calculated per vehicle and over a total driving range of 180 000 km using the average European electricity mix. Process-based attributional LCA and the ReCiPe characterisation method are used to estimate the climate change potential from the hierarchical perspective. The differently sized EVs are compared to one another to find the effect of increasing the size and range of EVs. We also point out the sources of differences in lifecycle emissions between conventional- and electric vehicles. Furthermore, a sensitivity analysis assesses the change in lifecycle emissions when electricity with various energy sources power the EVs. The sensitivity analysis also examines how the use phase electricity sources influences the size and range effect.

  13. Circular intensity differential scattering (CIDS) measurements in the soft x-ray region of the spectrum (@16 eV to 500 eV)

    Energy Technology Data Exchange (ETDEWEB)

    Maestre, M.F. (Lawrence Berkeley Lab., CA (United States)); Bustamante, C. (Oregon Univ., Eugene, OR (United States). Dept. of Chemistry); Snyder, P. (Florida Atlantic Univ., Boca Raton, FL (United States). Dept. of Chemistry); Rowe, E.; Hansen, R. (Wisconsin Univ., Stoughton, WI (United States). Synchrotron Radiation Center)

    1991-03-01

    We propose the use of recently developed techniques of circular intensity differential scattering (CIDS), as extended to the soft x-ray region of the spectrum (16 eV to 500 eV), to study the higher order organization of the eukaryotic chromosome. CIDS is the difference in scattering power of an object when illuminated by right circularly polarized vs. left circularly polarized electromagnetic radiation of arbitrary wavelength. CIDS has been shown to be a very sensitive measure of the helical organization of the scattering object eg. the eukaryotic chromosome. Preliminary results of measurements of samples of bacteriophages and octopus sperm done at SRC, Wisconsin, show the technique to be very sensitive to the dimensional parameters of the particles interrogated by circularly polarized light. 7 refs., 5 figs.

  14. New training simulators of state-of-the-art coal fired power plants at KRAFTWERKSSCHULE E.V.; Neue Schulungssimulatoren moderner Kohlekraftwerke bei der KRAFTWERKSSCHULE E.V.

    Energy Technology Data Exchange (ETDEWEB)

    Kroeck, Martin; Fehse, Klaus; Nacke, Heinrich [Kraftwerksschule e.V., Essen (Germany)

    2008-07-01

    For more than 20 years, KRAFTWERKSSCHULE E.V. (KWS - PowerTech Training Center) operates training simulators for fossil-fired power plants at its Essen headquarters. In the course of the construction of the new 800 MW and 1100 MW high-efficiency power plants with hypercritical steam generators, a growing demand for - even multilingual - training of operator personnel from such plants at simulators is arising. Thus, new training simulators are being erected. (orig.)

  15. Earth sciences within the project Ev-K2-CNR: Geodesy and geophysics; Le scienze della Terra nel progetto Ev-K2-CNR: Geodesia e geofisica

    Energy Technology Data Exchange (ETDEWEB)

    Poretti, Giorgio [Trieste, Univ. (Italy). Dipt. di Scienze Matematiche

    1997-05-01

    Earth Sciences started the Ev-K2-CNR project in 1987 with the comparison between the heights of Mt. Everest and K2. Several gravimetric campaigns followed in the most difficult areas of the Himalayas. In 1991 a GPS network was established in Nepal for the determination of the Earth crust movements in the area. In 1992 a precise measurement of mount Everest was performed with classical and satellite technologies. Mount K2 was remeasured in Summer 1996.

  16. Identification, synthesis and pharmacological evaluation of novel anti-EV71 agents via cyclophilin A inhibition.

    Science.gov (United States)

    Yan, Wenzhong; Qing, Jie; Mei, Hanbing; Nong, Junxiu; Huang, Jin; Zhu, Jin; Jiang, Hualiang; Liu, Lei; Zhang, Linqi; Li, Jian

    2015-12-15

    In this work, the relationship between cyclophilin A (CypA) and EV71 prompted us to screen a series of small molecular CypA inhibitors which were previously reported by our group. Among them, compounds 1 and 2 were discovered as non-immunosuppressive anti-EV71 agents with an EC50 values of 1.07±0.17μM and 3.36±0.45μM in virus assay, respectively, which were desirably for the further study. The subsequent chemical modifications derived a novel class of molecules, among which compound 11 demonstrated the most potent anti-EV71 activity in virus assay (EC50=0.37±0.17μM), and low cytotoxicity (CC50>25μM). The following CypA enzyme inhibition studies indicated that there was not only the enzyme inhibition activity, undoubtedly important, functioning in the antiviral process, but also some unknown mechanisms worked in combination, and the further study is underway in our laboratory. Nevertheless, to the best of our knowledge, compound 11 was probably the most potent small molecular anti-EV71 agent via CypA inhibitory mechanism to date. Consequently, our study provided a new potential small molecule for curing EV71 infection.

  17. Progress on the research and development of human enterovirus 71 (EV71) vaccines.

    Science.gov (United States)

    Liang, Zhenglun; Mao, Qunying; Gao, Fan; Wang, Junzhi

    2013-03-01

    Enterovirus 71 (EV71) infections, which can cause severe complications, have become one of the serious public health issues in the Western Pacific region and China. To date, a number of pharmaceutical companies and institutes have initiated the research and development of EV71 vaccines as a countermeasure. As is the case with innovative vaccine development, there are several critical bottlenecks in EV71 vaccine development that must be overcome before the clinical trials, including the selection of vaccine strain, standardization of the procedure for quantifying neutralizing antibody (NTAb) and antigen, establishment and application of a reference standard and biological standards, development of animal models for the evaluation of protective efficacy, and identification of the target patient population. To tackle these technical obstacles, researchers in Mainland of China have conducted a series of studies concerning the screening of vaccine strains and the establishment of criteria, biological standards and detection methods, thereby advancing EV71 vaccine development. This review summarizes recent worldwide progress on the quality control and evaluation of EV71 vaccines.

  18. Usage of Electric Vehicle Supply Equipment Along the Corridors between the EV Project Major Cities

    Energy Technology Data Exchange (ETDEWEB)

    Mindy Kirkpatrick

    2012-05-01

    The report explains how the EVSE are being used along the corridors between the EV Project cities. The EV Project consists of a nationwide collaboration between Idaho National Laboratory (INL), ECOtality North America, Nissan, General Motors, and more than 40 other city, regional and state governments, and electric utilities. The purpose of the EV Project is to demonstrate the deployment and use of approximately 14,000 Level II (208-240V) electric vehicle supply equipment (EVSE) and 300 fast chargers in 16 major cities. This research investigates the usage of all currently installed EV Project commercial EVSE along major interstate corridors. ESRI ArcMap software products are utilized to create geographic EVSE data layers for analysis and visualization of commercial EVSE usage. This research locates the crucial interstate corridors lacking sufficient commercial EVSE and targets locations for future commercial EVSE placement. The results and methods introduced in this research will be used by INL for the duration of the EV Project.

  19. An Estimate Of The Primary Mass Of Cosmic Rays At $10^{18}$ eV As Inferred From Volcano Ranch Data

    CERN Document Server

    Dova, M T; Mariazzi, A G; McCauley, T P; Watson, A A

    2003-01-01

    Accurate measurements of the lateral distribution of extensive air showers produced by cosmic rays of energy greater than $10^{17}$ eV were made in the 1970s by Linsley. At the time, the state of knowledge about the best hadronic interaction model to use to describe such data prevented conclusions about the cosmic ray mass from being drawn. We have used a modern model, {\\sc qgsjet98}, to infer the primary mass from these data, using the very careful records left by Linsley. We find that at a median energy of $10^{18}$ eV, the data are well described by an iron-dominated composition (88 $\\pm$ 6(stat) $\\pm$ 18 (syst))%. We discuss the systematic errors in this estimate that arise from model uncertainties and from the range of energies used in the work of Linsley. These data are used with the permission of the late John Linsley to whom this work is dedicated.

  20. Determination of the molecular structure via the medium energy electrons (500 eV-1,5 KeV) Ar, N2, Co e HCl

    International Nuclear Information System (INIS)

    Elastic Differential and Total Differential Cross Sections are measured for electron collision in medium-energy range (500 eV - 1,5 KeV) with argon, nitrogen, carbon monoxide and hydrogen chloride, all in their electronic ground state. Theoretical calculation for the Elastic Differential Cross Sections by atoms were done employing Hartree-Fock-Clementy wave function, and making use of Partial Wave and WKBJ Methods. Exchange effect is included in the case of argon. Independent Atom Model, Half Molecule Model and a new model, the Ionic Model were utilized for the molecular calculations. The Ionic Model is suggested for the interaction between HCl and electrons. Inelastic Differential Cross Section were also computed, making use of the First Born Approximation and Hartree-Fock-Clementi wave function. It is also demonstrated, for the first time, that medium energy electrons (500 eV - 1,5 Kev) can be used to determine molecular structure parameters, in gas phase

  1. CONSTRAINTS ON THE ORIGIN OF COSMIC RAYS ABOVE 10{sup 18} eV FROM LARGE-SCALE ANISOTROPY SEARCHES IN DATA OF THE PIERRE AUGER OBSERVATORY

    Energy Technology Data Exchange (ETDEWEB)

    Abreu, P.; Andringa, S. [LIP and Instituto Superior Tecnico, Technical University of Lisbon (Portugal); Aglietta, M. [Istituto di Fisica dello Spazio Interplanetario (INAF), Universita di Torino and Sezione INFN, Torino (Italy); Ahlers, M. [University of Wisconsin, Madison, WI (United States); Ahn, E. J. [Fermilab, Batavia, IL (United States); Albuquerque, I. F. M. [Universidade de Sao Paulo, Instituto de Fisica, Sao Paulo, SP (Brazil); Allard, D. [Laboratoire AstroParticule et Cosmologie (APC), Universite Paris 7, CNRS-IN2P3, Paris (France); Allekotte, I. [Centro Atomico Bariloche and Instituto Balseiro (CNEA-UNCuyo-CONICET), San Carlos de Bariloche (Argentina); Allen, J. [New York University, New York, NY (United States); Allison, P. [Ohio State University, Columbus, OH (United States); Almela, A. [Universidad Tecnologica Nacional - Facultad Regional Buenos Aires, Buenos Aires (Argentina); Castillo, J. Alvarez [Universidad Nacional Autonoma de Mexico, Mexico, D.F. (Mexico); Alvarez-Muniz, J. [Universidad de Santiago de Compostela (Spain); Alves Batista, R. [Universidade Estadual de Campinas, IFGW, Campinas, SP (Brazil); Ambrosio, M.; Aramo, C. [Universita di Napoli ' Federico II' and Sezione INFN, Napoli (Italy); Aminaei, A. [IMAPP, Radboud University Nijmegen (Netherlands); Anchordoqui, L. [University of Wisconsin, Milwaukee, WI (United States); Antici' c, T. [Rudjer Boskovi' c Institute, 10000 Zagreb (Croatia); Arganda, E. [IFLP, Universidad Nacional de La Plata and CONICET, La Plata (Argentina); Collaboration: Pierre Auger Collaboration; and others

    2013-01-01

    A thorough search for large-scale anisotropies in the distribution of arrival directions of cosmic rays detected above 10{sup 18} eV at the Pierre Auger Observatory is reported. For the first time, these large-scale anisotropy searches are performed as a function of both the right ascension and the declination and expressed in terms of dipole and quadrupole moments. Within the systematic uncertainties, no significant deviation from isotropy is revealed. Upper limits on dipole and quadrupole amplitudes are derived under the hypothesis that any cosmic ray anisotropy is dominated by such moments in this energy range. These upper limits provide constraints on the production of cosmic rays above 10{sup 18} eV, since they allow us to challenge an origin from stationary galactic sources densely distributed in the galactic disk and emitting predominantly light particles in all directions.

  2. Diagnosis of hand, foot, and mouth disease caused by EV71 and other enteroviruses by a one-step, single tube, duplex RT-PCR.

    Science.gov (United States)

    Jiang, Bingfu; Zhang, Jianhua; You, Xianhui; Dong, Chen; Cheng, Xianfeng; Dai, Xing; Meng, Jihong

    2012-11-01

    Hand, foot, and mouth disease (HFMD) is caused mainly by enterovirus 71 (EV71) and other enteroviruses (EVs) such as Coxsackie A16 in China. EV71 infection can lead to severe clinical manifestations and even death. Other EVs, however, generally cause mild symptoms. Thus, early and accurate distinction of EV71 from other EVs for HFMD will offer significant benefits. A one-step, single tube, duplex RT-PCR assay is described in the present study to detect simultaneously EV71 and other EVs. The primers used for the duplex RT-PCR underwent screening and optimization. The detection threshold was 0.001 TCID(50)/ml for EV71 and 0.01 TCID(50)/ml for other EVs. The positive rate of enterovirus detection in 165 clinical samples reached 68.5%, including 46.1% for EV71 and 22.4% for other EVs. Of all the severe HFMD cases, EV71 was responsible for 85.3% cases. The positive rate of EV71 fell markedly by day 8 after onset. In addition, sequencing of EV71 specific amplicons from duplex RT-PCR revealed that C4a was the predominant subgenotype of EV71 circulating in Nanjing, China. The accuracy and reliability of the assay suggest strongly that the one-step, single tube, duplex RT-PCR will be useful for early diagnosis and monitoring of EV71 and other EV infections.

  3. The extreme ultraviolet emission spectrum of CO produced by electron impact at 20 and 200 eV

    International Nuclear Information System (INIS)

    In this first part of a laboratory study of predissociation in CO we have measured the electron-impact-induced fluorescence spectrum of CO in the wavelength range 40-125 nm at a spectral resolution of 0.5nm. The experiment was performed in a cross-beam configuration under optically thin conditions. Our spectral measurements at 200 eV electron impact energy provide the emission cross sections of atomic dissociation fragments (C 1, C 11, O 1, O 11) and the vibrational transitions of the B1Σ+, C 1Σ+, E 1II-X 1Σ+ band systems of CO. The measured emission cross sections of these molecular transitions will be needed for comparison with excitation cross sections from electron energy-loss spectra to determine predissociation yields. (Author)

  4. The evolution of Vp1 gene in enterovirus C species sub-group that contains types CVA-21, CVA-24, EV-C95, EV-C96 and EV-C99.

    Directory of Open Access Journals (Sweden)

    Teemu Smura

    Full Text Available Genus Enterovirus (Family Picornaviridae, consists of twelve species divided into genetically diverse types by their capsid protein VP1 coding sequences. Each enterovirus type can further be divided into intra-typic sub-clusters (genotypes. The aim of this study was to elucidate what leads to the emergence of novel enterovirus clades (types and genotypes. An evolutionary analysis was conducted for a sub-group of Enterovirus C species that contains types Coxsackievirus A21 (CVA-21, CVA-24, Enterovirus C95 (EV-C95, EV-C96 and EV-C99. VP1 gene datasets were collected and analysed to infer the phylogeny, rate of evolution, nucleotide and amino acid substitution patterns and signs of selection. In VP1 coding gene, high intra-typic sequence diversities and robust grouping into distinct genotypes within each type were detected. Within each type the majority of nucleotide substitutions were synonymous and the non-synonymous substitutions tended to cluster in distinct highly polymorphic sites. Signs of positive selection were detected in some of these highly polymorphic sites, while strong negative selection was indicated in most of the codons. Despite robust clustering to intra-typic genotypes, only few genotype-specific 'signature' amino acids were detected. In contrast, when different enterovirus types were compared, there was a clear tendency towards fixation of type-specific 'signature' amino acids. The results suggest that permanent fixation of type-specific amino acids is a hallmark associated with evolution of different enterovirus types, whereas neutral evolution and/or (frequency-dependent positive selection in few highly polymorphic amino acid sites are the dominant forms of evolution when strains within an enterovirus type are compared.

  5. Polarization of Lyman-β radiation from atomic hydrogen excited by electron impact from near-threshold energy to 1000 eV

    International Nuclear Information System (INIS)

    The polarization of Lyman-β radiation, produced by electron-impact excitation of atomic hydrogen, has been measured over the extended energy range from near threshold to 1000 eV. Measurements were obtained in a crossed-beams experiment using a silica-reflection linear polarization analyzer in tandem with a vacuum ultraviolet monochromator to isolate the emitted line radiation. Our data are in excellent agreement with convergent close-coupling calculations over the entire energy range. The data are broadly similar to the earlier measurements of H Lyman-α polarization reported from the Jet Propulsion Laboratory

  6. Circular polarization measurements of Lyman-α radiation from the decay of the 22Pj states of hydrogen excited by 54.4 eV electrons

    International Nuclear Information System (INIS)

    New coincidence measurements are reported for the circular polarization of Lyman-α radiation resulting from the decay of 22Pj states excited by electron impact at an incident energy of 54.4 eV in a range of scattering angles from 5o ≤ θe ≤ 40o. The data were obtained using a recently developed efficient polarization analyser for this spectral line and the statistical significance of the data is much better than for previously reported measurements. The data are analysed to yield values for the coherence parameter P+ and show that spin exchange interactions play a significant, if unexpected, role in the dynamic range investigated. (author)

  7. Construction and characterization of infectious cDNA clones of enterovirus 71(EV71)

    Institute of Scientific and Technical Information of China (English)

    Ying-wei; Ma; Shu-bin; Hao; Le-le; Sun; Jing; Li; Qiao; Qiao; Feng; Gao; Li; Zhao; Xue-jie; Yu; Zhi-yu; Wang; Hong-ling; Wen

    2015-01-01

    Dear Editor,Enterovirus 71(EV71),a member of the genus Enterovirus of the family Picornaviridae,is a single-stranded,positive-sense RNA virus that usually causes mild handfoot-mouth disease(HFMD)in children,with symptoms such as fever,diarrhea,and herpangina(Liu et al.,2013).However,certain strains of EV71 infection can cause severe neurological complications,such as SDLY107(Sun et al.,2014).EV71 is classified into three distinct genotypes(A–C);the B and C genotypes are further divided into B1–B5 and C1–C5 genotypes,respectively,based on

  8. Radar Observations and the Shape of Near-Earth Asteroid 2008 EV5

    CERN Document Server

    Busch, Michael W; Benner, Lance A M; Brozovic, Marina; Giorgini, Jon D; Jao, Joseph S; Scheeres, Daniel J; Magri, Christopher; Nolan, Michael C; Howell, Ellen S; Taylor, Patrick A; Margot, Jean-Luc; Brisken, Walter

    2011-01-01

    We observed the near-Earth asteroid 2008 EV5 with the Arecibo and Goldstone planetary radars and the Very Long Baseline Array during December 2008. EV5 rotates retrograde and its overall shape is a 400 /pm 50 m oblate spheroid. The most prominent surface feature is a ridge parallel to the asteroid's equator that is broken by a concavity 150 m in diameter. Otherwise the asteroid's surface is notably smooth on decameter scales. EV5's radar and optical albedos are consistent with either rocky or stony-iron composition. The equatorial ridge is similar to structure seen on the rubble-pile near-Earth asteroid (66391) 1999 KW4 and is consistent with YORP spin-up reconfiguring the asteroid in the past. We interpret the concavity as an impact crater. Shaking during the impact and later regolith redistribution may have erased smaller features, explaining the general lack of decameter-scale surface structure.

  9. EV-A71 vaccine licensure: a first step for multivalent enterovirus vaccine to control HFMD and other severe diseases.

    Science.gov (United States)

    Mao, Qunying; Wang, Yiping; Bian, Lianlian; Xu, Miao; Liang, Zhenglun

    2016-01-01

    Enteroviruses (EVs) are the most common viral agents in humans. Although most infections are mild or asymptomatic, there is a wide spectrum of clinical manifestations that may be caused by EV infections with varying degrees of severity. Among these viruses, EV-A71 and coxsackievirus (CV) CV-A16 from group A EVs attract the most attention because they are responsible for hand, foot and mouth disease (HFMD). Other EV-A viruses such as CV-A6 and CV-A10 were also reported to cause HFMD outbreaks in several countries or regions. Group B EVs such as CV-B3, CV-B5 and echovirus 30 were reported to be the main pathogens responsible for myocarditis and encephalitis epidemics and were also detected in HFMD patients. Vaccines are the best tools to control infectious diseases. In December 2015, China's Food and Drug Administration approved two inactivated EV-A71 vaccines for preventing severe HFMD.The CV-A16 vaccine and the EV-A71-CV-A16 bivalent vaccine showed substantial efficacy against HFMD in pre-clinical animal models. Previously, research on EV-B group vaccines was mainly focused on CV-B3 vaccine development. Because the HFMD pathogen spectrum has changed, and the threat from EV-B virus-associated severe diseases has gradually increased, it is necessary to develop multivalent HFMD vaccines. This study summarizes the clinical symptoms of diseases caused by EVs, such as HFMD, myocarditis and encephalitis, and the related EV vaccine development progress. In conclusion, developing multivalent EV vaccines should be strongly recommended to prevent HFMD, myocarditis, encephalitis and other severe diseases. PMID:27436364

  10. EV Charging Facilities and Their Application in LV Feeders with Photovoltaics

    DEFF Research Database (Denmark)

    Marra, Francesco; Yang, Guangya; Træholt, Chresten;

    2013-01-01

    several limits. We introduce the use of electric vehicle (EV) public charging stations with energy storage system (ESS) as a solution for voltage regulation in LV feeders with PV. A novel method is proposed to determine the ESS charging load required for voltage regulation and compare the results...... for the different locations in the feeder. With time-series simulations, we quantify the energy size required for a station ESS. A Belgian LV residential grid, modeled using real PV generation and load profiles, is used as case study. The method and simulation results show the effectiveness of using public EV...... charging facilities with the additional function of voltage regulation in feeders with PV....

  11. Vloga staršev pri vključevanju otrok v sodobni ples

    OpenAIRE

    Verglez, Tanja

    2016-01-01

    V diplomskem delu preučujemo vlogo staršev pri vključevanju otrok v sodobni ples. V teoretičnem delu najprej predstavljamo nekatera dosedanja dognanja na področju gibalnega razvoja v zgodnjem otroštvu ter neločljivo vzajemno povezanost gibalnih in kognitivnih sposobnosti, ki so individualno pogojene. Pedagoški proces v sodobnem plesu se namreč naslanja na poznavanje slednjega. Vloga staršev pri izbiri organiziranih gibalnih/športnih in seveda tudi plesnih dejavnosti je kompleksna in široka. S...

  12. Impact Study of Electric Vehicle (EV) Integration on Medium Voltage (MV) Grids

    DEFF Research Database (Denmark)

    Wu, Qiuwei; Nielsen, Arne Hejde; Østergaard, Jacob;

    2011-01-01

    The impact study of electric vehicle (EV) grid integration on medium voltage (MV) grids was carried out to quantify the power component loading and voltage profile change in MV grids due to the extra demands from the EV charging. Three charging scenarios, dumb charging, time charging and fleet...... operator based charging, were considered in the impact study to assess the impacts of different charging options. In the mean time, different charging power levels were included in the impact study as well. A MV grid from the Bornholm power system was used to implement the case studies....

  13. Developing Online Marketing in Social Media for DORTMUNDtourismus e.V.

    OpenAIRE

    Steinrücken, Thomas

    2010-01-01

    The thesis discussed the topic of online marketing in social media. The focus was set on the social media platforms Facebook, YouTube and Flickr. Commissioner of the thesis was DORTMUNDtourismus e.V., the destination management organization for Dortmund, Germany. The research problem was to identify ways to develop online marketing in social media in a cost-efficient and innovative way in order to raise the awareness of DORTMUNDtourismus e.V. and Dortmund in social media and as a destination....

  14. KOMUNIKACIJA IN ZADOVOLJSTVO STARŠEV Z VRTCI OBČINE ŽALEC

    OpenAIRE

    Špacapan, Boštjan

    2013-01-01

    V diplomskem delu s področja organizacije predšolske vzgoje smo ugotavljali, v kakšni povezanosti sta komunikacija in zadovoljstvo pri starših otrok. V teoretičnem delu so povzeti temeljni elementi komunikacije. V tem delu je prav tako obravnavana komunikacija v procesu predšolske vzgoje. V raziskovalnem delu smo ugotavljali ali obstaja povezanost med zadovoljstvom staršev s komunikacijo strokovnih delavcev in prisotnostjo staršev na govorilnih urah in rednih roditeljskih sestankih. Ugotavlja...

  15. EnEV compact. Collection of texts according to the energy conservation ordinance 2009 and thermal insulation regulations; EnEV kompakt. Textsammlung zur Energieeinsparverordnung 2009 und den Waermeschutzverordnungen

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2009-07-01

    The actual energy conservation ordinance (EnEV) came into force at 1st October, 2009. With the amended EnEV 2009, the energetic requirements at new buildings and redevelopments are intensified. The novella EnEV 2009 is a component of the Integrated Energy and Climatic Program (IEKP) of the Federal Government. The collection of texts of the German Energy Agency (Berlin, Federal Republic of Germany) contains the complete text of the EnEV 2009, the accompanying proclamations of the Federal Ministry of Transport, Building and Urban Development (Berlin, Federal Republic of Germany) as well as the thermal insulation regulations of 1977, 1982 and 1994.

  16. A Method for Remote Control of EV Charging by Modifying IEC61851 Compliant EVSE Based PWM Signal

    DEFF Research Database (Denmark)

    Pedersen, Anders Bro; Martinenas, Sergejus; Andersen, Peter Bach;

    2016-01-01

    The Electric Vehicle (EV) has properties that can not only load but can elevate its value as a resource to the power system. An EV represents a high-power, fast-responding flexible demand unit, with an attached energy storage (battery) and the potential for bi-directional capabilities (V2G......). These properties can be used in a number of power and energy services, which can support power system operation while lowering the cost of EV ownership. Such services depend on the support from the communications technologies and standards that connect controllers and logic in the EVs with those in the charging...... infrastructure- and back-end systems. To date, there is still no widely adopted standard that supports EV grid services, such as smart charging. This work proposes a solution that would allow any combination of charging spot and EV - individually lacking the logic, communication and controllability required...

  17. What kind of charging infrastructure do Chevrolet Volts Drivers in The EV Project use?

    Energy Technology Data Exchange (ETDEWEB)

    John Smart

    2013-09-01

    This report summarizes key conclusions from analysis of data collected from Chevrolet Volts participating in The EV Project. Topics include how much Volt drivers charge at level 1 vs. level 2 rates and how much they charge at home vs. away from home.

  18. Coordinated Control of PV Generation and EVs Charging Based on Improved DECell Algorithm

    Directory of Open Access Journals (Sweden)

    Guo Zhao

    2015-01-01

    Full Text Available Recently, the coordination of EVs’ charging and renewable energy has become a hot research all around the globe. Considering the requirements of EV owner and the influence of the PV output fluctuation on the power grid, a three-objective optimization model was established by controlling the EVs charging power during charging process. By integrating the meshing method into differential evolution cellular (DECell genetic algorithm, an improved differential evolution cellular (IDECell genetic algorithm was presented to solve the multiobjective optimization model. Compared to the NSGA-II and DECell, the IDECell algorithm showed better performance in the convergence and uniform distribution. Furthermore, the IDECell algorithm was applied to obtain the Pareto front of nondominated solutions. Followed by the normalized sorting of the nondominated solutions, the optimal solution was chosen to arrive at the optimized coordinated control strategy of PV generation and EVs charging. Compared to typical charging pattern, the optimized charging pattern could reduce the fluctuations of PV generation output power, satisfy the demand of EVs charging quantity, and save the total charging cost.

  19. Dissociative Electron Attachment to Carbon Dioxide via the 8.2 eV Feshbach resonance

    Energy Technology Data Exchange (ETDEWEB)

    Slaughter, Dan; Adaniya, Hidihito; Rescigno, Tom; Haxton, Dan; Orel, Ann; McCurdy, Bill; Belkacem, Ali

    2011-08-17

    Momentum imaging experiments on dissociative electron attachment (DEA) to CO{sub 2} are combined with the results of ab initio calculations to provide a detailed and consistent picture of the dissociation dynamics through the 8.2 eV resonance, which is the major channel for DEA in CO{sub 2}. The present study resolves several puzzling misconceptions about this system.

  20. What kind of charging infrastructure do Nissan Leaf drivers in The EV Project use?

    Energy Technology Data Exchange (ETDEWEB)

    Shawn Salisbury

    2014-09-01

    This document will describe the charging behavior of Nissan Leaf battery electric vehicles that were enrolled in the EV Project. It will include aggregated data from several thousand vehicles regarding time-of-day, power level, and location of charging and driving events. This document is a white paper that will be published on the INL AVTA website.

  1. Crystal structures of enterovirus 71 (EV71) recombinant virus particles provide insights into vaccine design.

    Science.gov (United States)

    Lyu, Ke; Wang, Guang-Chuan; He, Ya-Ling; Han, Jian-Feng; Ye, Qing; Qin, Cheng-Feng; Chen, Rong

    2015-02-01

    Hand-foot-and-mouth disease (HFMD) remains a major health concern in the Asia-Pacific regions, and its major causative agents include human enterovirus 71 (EV71) and coxsackievirus A16. A desirable vaccine against HFMD would be multivalent and able to elicit protective responses against multiple HFMD causative agents. Previously, we have demonstrated that a thermostable recombinant EV71 vaccine candidate can be produced by the insertion of a foreign peptide into the BC loop of VP1 without affecting viral replication. Here we present crystal structures of two different naturally occurring empty particles, one from a clinical C4 strain EV71 and the other from its recombinant virus containing an insertion in the VP1 BC loop. Crystal structure analysis demonstrated that the inserted foreign peptide is well exposed on the particle surface without significant structural changes in the capsid. Importantly, such insertions do not seem to affect the virus uncoating process as illustrated by the conformational similarity between an uncoating intermediate of another recombinant virus and that of EV71. Especially, at least 18 residues from the N terminus of VP1 are transiently externalized. Altogether, our study provides insights into vaccine development against HFMD.

  2. Experimental study on EV purchases assisted by multi-agents representing a set of questionnaires

    DEFF Research Database (Denmark)

    Xue, Yusheng; Wu, Juai; Xie, Dongliang;

    2014-01-01

    An experimental economics (EE) method is used to analyze the influences of subjective willingness on the development of the electric vehicle (EV) industry. It is difficult to run large-scale EE-based simulations and to support decision optimizations due to the limited number of qualified human pa...

  3. The EVS: a computerized decision support system for GPs in the Netherlands.

    NARCIS (Netherlands)

    Wolters, I.; Hoogen, H. van den; Bakker, D. de

    2003-01-01

    Background: In 1998 a project was started to introduce nationally a decision support system in general practice in the Netherlands, called EVS (electronic prescription support system). The system contains national guidelines developed by the Dutch Council of GPs (NHG) for approximately 80 diagnoses.

  4. Vabariigi aastapäev Ottawas Taani suursaadiku osalemisel / Walter Pent

    Index Scriptorium Estoniae

    Pent, Walter

    2003-01-01

    EV 85. aastapäeva üritusel pidas kõne Taani suursaadik Kanadas Svend R. Nielsen ning anti üle Kotkaristi Kuldrist Ottawa Eesti Seltsi esimehele, lennuväekolonel Margus Arujale teenete eest eesti sõjaväe loomisele kaasaaitamisel\\

  5. Invent--Innovate--Implement--Interview with Dr. Christian Schaefer, Senior Vice President Sales, EV Group

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    @@ Dr. Christian Schaefer, Senior Vice President Sales of EV Group, has 15 years of international management experience in the materials and equipment industry. During his tenure, Schaefer spearheaded the consolidation 9f RHI following the first Asian crisis and guided the company through major mergers and acquisitions,accomplishments that ultimately helped the company increase market share, revenues and profits.

  6. Measurement of the depth of maximum of extensive air showers above 1018eV

    NARCIS (Netherlands)

    Abraham, J.; Abreu, P.; Aglietta, M.; Ahn, E. J.; Allard, D.; Allekotte, I.; Allen, J.; Alvarez-Muñiz, J.; Ambrosio, M.; Anchordoqui, L.; Andringa, S.; Antičić, T.; Anzalone, A.; Aramo, C.; Arganda, E.; Arisaka, K.; Arqueros, F.; Asorey, H.; Assis, P.; Aublin, J.; Ave, M.; Avila, G.; Bäcker, T.; Badagnani, D.; Balzer, M.; Barber, K. B.; Barbosa, A. F.; Barroso, S. L. C.; Baughman, B.; Bauleo, P.; Beatty, J. J.; Becker, B. R.; Becker, K. H.; Bellétoile, A.; Bellido, J. A.; Benzvi, S.; Berat, C.; Bergmann, T.; Bertou, X.; Biermann, P. L.; Billoir, P.; Blanch-Bigas, O.; Blanco, F.; Blanco, M.; Bleve, C.; Blümer, H.; Boháčová, M.; Boncioli, D.; Bonifazi, C.; Bonino, R.; Borodai, N.; Brack, J.; Brogueira, P.; Brown, W. C.; Bruijn, R.; Buchholz, P.; Bueno, A.; Burton, R. E.; Busca, N. G.; Caballero-Mora, K. S.; Caramete, L.; Caruso, R.; Castellina, A.; Catalano, O.; Cataldi, G.; Cazon, L.; Cester, R.; Chauvin, J.; Chiavassa, A.; Chinellato, J. A.; Chou, A.; Chudoba, J.; Clay, R. W.; Colombo, E.; Coluccia, M. R.; Conceição, R.; Contreras, F.; Cook, H.; Cooper, M. J.; Coppens, J.; Cordier, A.; Cotti, U.; Coutu, S.; Covault, C. E.; Creusot, A.; Criss, A.; Cronin, J.; Curutiu, A.; Dagoret-Campagne, S.; Dallier, R.; Daumiller, K.; Dawson, B. R.; de Almeida, R. M.; de Domenico, M.; de Donato, C.; de Jong, S. J.; de La Vega, G.; de Mello Junior, W. J. M.; de Mello Neto, J. R. T.; de Mitri, I.; de Souza, V.; de Vries, K.D.; Decerprit, G.; Del Peral, L.; Deligny, O.; Della Selva, A.; Delle Fratte, C.; Dembinski, H.; di Giulio, C.; Diaz, J. C.; Díaz Castro, M. L.; Diep, P. N.; Dobrigkeit, C.; D'Olivo, J. C.; Dong, P. N.; Dorofeev, A.; Dos Anjos, J. C.; Dova, M. T.; D'Urso, D.; Dutan, I.; Duvernois, M. A.; Ebr, J.; Engel, R.; Erdmann, M.; Escobar, C. O.; Etchegoyen, A.; Facal San Luis, P.; Falcke, H.; Farrar, G.; Fauth, A. C.; Fazzini, N.; Ferrero, A.; Fick, B.; Filevich, A.; Filipčič, A.; Fleck, I.; Fliescher, S.; Fracchiolla, C. E.; Fraenkel, E. D.; Fröhlich, U.; Fulgione, W.; Gamarra, R. F.; Gambetta, S.; García, B.; García Gámez, D.; Garcia-Pinto, D.; Garrido, X.; Gelmini, G.; Gemmeke, H.; Ghia, P. L.; Giaccari, U.; Giller, M.; Glass, H.; Goggin, L. M.; Gold, M. S.; Golup, G.; Gomez Albarracin, F.; Gómez Berisso, M.; Gonçalves, P.; Gonzalez, D.; Gonzalez, J. G.; Góra, D.; Gorgi, A.; Gouffon, P.; Gozzini, S. R.; Grashorn, E.; Grebe, S.; Grigat, M.; Grillo, A. F.; Guardincerri, Y.; Guarino, F.; Guedes, G. P.; Hague, J. D.; Halenka, V.; Hansen, P.; Harari, D.; Harmsma, S.; Harton, J. L.; Haungs, A.; Hebbeker, T.; Heck, D.; Herve, A. E.; Hojvat, C.; Holmes, V. C.; Homola, P.; Hörandel, J. R.; Horneffer, A.; Hrabovský, M.; Huege, T.; Hussain, M.; Iarlori, M.; Insolia, A.; Ionita, F.; Italiano, A.; Jiraskova, S.; Kadija, K.; Kaducak, M.; Kampert, K. H.; Karova, T.; Kasper, P.; Kégl, B.; Keilhauer, B.; Keivani, A.; Kelley, J.; Kemp, E.; Kieckhafer, R. M.; Klages, H. O.; Kleifges, M.; Kleinfeller, J.; Knapik, R.; Knapp, J.; Koang, D.-H.; Krieger, A.; Krömer, O.; Kruppke-Hansen, D.; Kuehn, F.; Kuempel, D.; Kulbartz, K.; Kunka, N.; Kusenko, A.; La Rosa, G.; Lachaud, C.; Lago, B. L.; Lautridou, P.; Leão, M. S. A. B.; Lebrun, D.; Lebrun, P.; Lee, J.; Leigui de Oliveira, M. A.; Lemiere, A.; Letessier-Selvon, A.; Lhenry-Yvon, I.; López, R.; Lopez Agüera, A.; Louedec, K.; Lozano Bahilo, J.; Lucero, A.; Ludwig, M.; Lyberis, H.; Maccarone, M. C.; Macolino, C.; Maldera, S.; Mandat, D.; Mantsch, P.; Mariazzi, A. G.; Marin, V.; Maris, I. C.; Marquez Falcon, H. R.; Marsella, G.; Martello, D.; Martínez Bravo, O.; Mathes, H. J.; Matthews, J.; Matthews, J. A. J.; Matthiae, G.; Maurizio, D.; Mazur, P. O.; McEwen, M.; Medina-Tanco, G.; Melissas, M.; Melo, D.; Menichetti, E.; Menshikov, A.; Meurer, C.; Mičanović, S.; Micheletti, M. I.; Miller, W.; Miramonti, L.; Mollerach, S.; Monasor, M.; Monnier Ragaigne, D.; Montanet, F.; Morales, B.; Morello, C.; Moreno, E.; Moreno, J. C.; Morris, C.; Mostafá, M.; Mueller, S.; Muller, M. A.; Mussa, R.; Navarra, G.; Navarro, J. L.; Navas, S.; Necesal, P.; Nellen, L.; Nhung, P. T.; Nierstenhoefer, N.; Nitz, D.; Nosek, D.; Nožka, L.; Nyklicek, M.; Oehlschläger, J.; Olinto, A.; Oliva, P.; Olmos-Gilbaja, V. M.; Ortiz, M.; Pacheco, N.; Pakk Selmi-Dei, D.; Palatka, M.; Pallotta, J.; Palmieri, N.; Parente, G.; Parizot, E.; Parlati, S.; Parra, A.; Parrisius, J.; Parsons, R. D.; Pastor, S.; Paul, T.; Pavlidou, V.; Payet, K.; Pech, M.; Pękala, J.; Pelayo, R.; Pepe, I. M.; Perrone, L.; Pesce, R.; Petermann, E.; Petrera, S.; Petrinca, P.; Petrolini, A.; Petrov, Y.; Petrovic, J.; Pfendner, C.; Piegaia, R.; Pierog, T.; Pimenta, M.; Pirronello, V.; Platino, M.; Ponce, V. H.; Pontz, M.; Privitera, P.; Prouza, M.; Quel, E. J.; Rautenberg, J.; Ravel, O.; Ravignani, D.; Redondo, A.; Revenu, B.; Rezende, F. A. S.; Ridky, J.; Riggi, S.; Risse, M.; Ristori, P.; Rivière, C.; Rizi, V.; Robledo, C.; Rodriguez, G.; Rodriguez Martino, J.; Rodriguez Rojo, J.; Rodriguez-Cabo, I.; Rodríguez-Frías, M. D.; Ros, G.; Rosado, J.; Rossler, T.; Roth, M.; Rouillé-D'Orfeuil, B.; Roulet, E.; Rovero, A. C.; Salamida, F.; Salazar, H.; Salina, G.; Sánchez, F.; Santander, M.; Santo, C. E.; Santos, E.; Santos, E. M.; Sarazin, F.; Sarkar, S.; Sato, R.; Scharf, N.; Scherini, V.; Schieler, H.; Schiffer, P.; Schmidt, A.; Schmidt, F.; Schmidt, T.; Scholten, O.; Schoorlemmer, H.; Schovancova, J.; Schovánek, P.; Schroeder, F.; Schulte, S.; Schüssler, F.; Schuster, D.; Sciutto, S. J.; Scuderi, M.; Segreto, A.; Semikoz, D.; Settimo, M.; Shadkam, A.; Shellard, R. C.; Sidelnik, I.; Siffert, B. B.; Sigl, G.; Śmiałkowski, A.; Šmída, R.; Snow, G. R.; Sommers, P.; Sorokin, J.; Spinka, H.; Squartini, R.; Stasielak, J.; Stephan, M.; Strazzeri, E.; Stutz, A.; Suarez, F.; Suomijärvi, T.; Supanitsky, A. D.; Šuša, T.; Sutherland, M. S.; Swain, J.; Szadkowski, Z.; Tamashiro, A.; Tamburro, A.; Tapia, A.; Tarutina, T.; Taşcău, O.; Tcaciuc, R.; Tcherniakhovski, D.; Tegolo, D.; Thao, N. T.; Thomas, D.; Tiffenberg, J.; Timmermans, C.; Tkaczyk, W.; Todero Peixoto, C. J.; Tomé, B.; Tonachini, A.; Travnicek, P.; Tridapalli, D. B.; Tristram, G.; Trovato, E.; Tueros, M.; Ulrich, R.; Unger, M.; Urban, M.; Valdés Galicia, J. F.; Valiño, I.; Valore, L.; van den Berg, A. M.; Vázquez, J. R.; Vázquez, R. A.; Veberič, D.; Venters, T.; Verzi, V.; Videla, M.; Villaseñor, L.; Vorobiov, S.; Voyvodic, L.; Wahlberg, H.; Wahrlich, P.; Wainberg, O.; Warner, D.; Watson, A. A.; Westerhoff, S.; Whelan, B. J.; Wieczorek, G.; Wiencke, L.; Wilczyńska, B.; Wilczyński, H.; Williams, C.; Winchen, T.; Winnick, M. G.; Wundheiler, B.; Yamamoto, T.; Younk, P.; Yuan, G.; Yushkov, A.; Zas, E.; Zavrtanik, D.; Zavrtanik, M.; Zaw, I.; Zepeda, A.; Ziolkowski, M.; Pierre Auger Collaboration, [No Value

    2010-01-01

    We describe the measurement of the depth of maximum, Xmax⁡, of the longitudinal development of air showers induced by cosmic rays. Almost 4000 events above 1018eV observed by the fluorescence detector of the Pierre Auger Observatory in coincidence with at least one surface detector station are selec

  7. ev kukub põgeneja käest : [luuletused] / Helgi Muller

    Index Scriptorium Estoniae

    Muller, Helgi, 1932-1971

    2003-01-01

    Sisu: Kui minu tuppa ei kostaks ; Imelind ; Kodumaa ; Karikakar I ; "Taevas vaatab sind ..." ; Öö musta jõge pidi ; Põuavägud ; "Kas põletada ..." ; Pihud ; Hingetuisk ; "Nagu hüüd ..." ; Päev jälle kukub käest. Eluloolisi andmeid autori kohta lk. 192

  8. Damage threshold of amorphous carbon mirror for 177 eV FEL radiation

    NARCIS (Netherlands)

    Farahani, S. D.; Chalupsky, J.; Burian, T.; Chapman, H.; Gleeson, A. J.; Hajkoya, V.; Juha, L.; Jurek, M.; Klinger, D.; Sinn, H.; Sobierajski, R.; Stormer, M.; Tiedtke, K.; Toleikis, S.; Tschentscher, T.; Wabnitz, H.; Gaudin, J.

    2011-01-01

    We present results of damage studies performed at the Free-Electron LASer in Hamburg (FLASH) on amorphous carbon (a-C). The experiment was performed in the total external reflection geometry representing the working configuration of X-ray mirrors. The 177 eV photon laser beam was focused on a 40 nm

  9. Measurement of neutron capture cross-section of the 71Ga(n, γ) 72Ga reaction at 0.0536 eV energy

    Science.gov (United States)

    Uddin, M. S.; Chowdhury, M. H.; Hossain, S. M.; Latif, Sk. A.; Hafiz, M. A.; Islam, M. A.; Zakaria, A. K. M.; Yunus, S. M.; Azharul Islam, S. M.

    2008-08-01

    The neutron capture cross-section for the 71Ga(n, γ) 72Ga reaction at 0.0536 eV energy was measured using activation technique based on TRIGA Mark-II research reactor. The 197Au(n, γ) 198Au monitor reaction was used to determine the effective neutron flux. Neutron absorption and γ-ray attenuation in gallium oxide pellet were corrected in determination of cross-section. The cross-section for the above reaction at 0.0536 eV amounts to 2.75 ± 0.14 b. As far as we know there are no experimental data available at our investigated energy. So far we are the first, who carried out experiment with 0.0536 eV neutrons for cross-section measurement. The present result is larger than that of JENDL-3.3, but consistent within the uncertainty range. The value of ENDF/B-VII is higher than this work. The result of this work will be useful to observe energy dependence of neutron capture cross-sections.

  10. Equal energy sharing double photo ionization of the Helium atom at 20eV and 40eV above threshold

    OpenAIRE

    Das, J. N.; Chakrabarti, K.; Paul, S

    2003-01-01

    In this article we present triple differential cross sections for equal energy sharing kinematics for double photoionization of the helium atom at 20 and 40eV above threshold in the framework of the hyperspherical partial wave theory. This supplements our earlier work \\cite{DCP03} in which we were successful in showing fully, gauge independence of the results in our formalism. Also in this work we treat cases in which the Stokes parameter S$_1 < 1$ so that partial polarization of the photon s...

  11. EV71可感染幼龄中缅树鼩%Experimental studies on infant Tupaia belangeri chineses with EV71 infection

    Institute of Scientific and Technical Information of China (English)

    王文广; 黄晓燕; 徐娟; 孙晓梅; 代解杰; 李琦涵

    2012-01-01

    Tupaia belonged are small mammals with a squirrel-like appearance; they were formerly classified under the primates order despite the lack of derived features characteristic of primates. Given that T. Belangeri are easy to raise, cheap to maintain, and have a small body size, a high reproductive rate, and close affinity to primates, these animals would be used as an alternative to primates in biomedical research. Three-month old T. Belangeri chineses were infected with enterovirus 71 (EV71) via three different routes, namely, oral administration, nasal dripping, and tail intravenous injection, to study the infection in infant T. Belangeri and find a feasible scheme to make them an ideal animal model of EV71 in place of primates. Daily activities were regularly observed, body temperatures were measured, and blood tests were conducted. Blood and fecal samples were regularly collected. The infection was examined via the neutralizing antibody test, reverse transcription polymerase chain reaction (RT-PCR), Real-Time PCR, and pathological analysis. The temperature, as well as the white blood cell count and the number of lymphocytes, increased four days after infection. Virus loads were determined in all three groups, and the peak appeared on, before, or after the tenth day, respectively. Thus, oral administration proved to be the best route. The highest serum antibody titer obtained was 1:16. Acute paralysis with urinary retention manifested after about two weeks, and pathological changes were observed in the brain, heart, lung, spleen, kidney, and other tissues. In conclusion, T. Belangeri chineses can infected with EV71 via oral administration, nasal dripping, and tail intravenous injection. Therefore, T. Belangeri are potential EV71 animal models for further studies on the mechanism of pathogenesis or vaccine evaluation.%树鼩是灵长类动物的近亲,且具有体型小、繁殖周期短、饲养管理成本低等优点,长期以来被认为有望替代灵长类

  12. Monoclonal neutralizing antibodies against EV71 screened from mice immunized with yeast-produced virus-like particles

    Institute of Scientific and Technical Information of China (English)

    Tao; Lin; Lingzhi; Xianyu; Songya; Lyu

    2015-01-01

    Periodic outbreaks of hand, foot and mouth disease(HFMD) occur in children under 5 years old, and can cause death in some cases. The C4 strain of enterovirus 71(EV71) is the main pathogen that causes HFMD in China. Although no drugs against EV71 are available, some studies have shown that candidate vaccines or viral capsid proteins can produce anti-EV71 immunity. In this study, female BABL/c mice(6–8 weeks old) were immunized with virus-like particles(VLPs) of EV71 produced in yeast to screen for anti-EV71 antibodies. Two hybridomas that could produce neutralizing antibodies against EV71 were obtained. Both neutralizing m Abs(D4 and G12) were confirmed to bind the VP1 capsid protein of EV71, and could protect > 95% cells from 100 TCID50 EV71 infection at 25 μg/m L solution(lowest concentration). Those two neutralizing m Abs identified in the study may be promising candidates in development for m Abs to treat EV71 infection, and utilized as suitable reagents for use in diagnostic tests and biological studies.

  13. Monoclonal neutralizing antibodies against EV71 screened from mice immunized with yeast-produced virus-like particles.

    Science.gov (United States)

    Lin, Tao; Xianyu, Lingzhi; Lyu, Songya

    2015-06-01

    Periodic outbreaks of hand, foot and mouth disease (HFMD) occur in children under 5 years old, and can cause death in some cases. The C4 strain of enterovirus 71 (EV71) is the main pathogen that causes HFMD in China. Although no drugs against EV71 are available, some studies have shown that candidate vaccines or viral capsid proteins can produce anti-EV71 immunity. In this study, female BABL/c mice (6-8 weeks old) were immunized with virus-like particles (VLPs) of EV71 produced in yeast to screen for anti-EV71 antibodies. Two hybridomas that could produce neutralizing antibodies against EV71 were obtained. Both neutralizing mAbs (D4 and G12) were confirmed to bind the VP1 capsid protein of EV71, and could protect >95% cells from 100 TCID50 EV71 infection at 25 µg/mL solution (lowest concentration). Those two neutralizing mAbs identified in the study may be promising candidates in development for mAbs to treat EV71 infection, and utilized as suitable reagents for use in diagnostic tests and biological studies.

  14. Activation of PI3K/Akt pathway limits JNK-mediated apoptosis during EV71 infection.

    Science.gov (United States)

    Zhang, Hua; Li, Fengqi; Pan, Ziye; Wu, Zhijun; Wang, Yanhong; Cui, Yudong

    2014-11-01

    Apoptosis is frequently induced to inhibit virus replication during infection of Enterovirus 71 (EV71). On the contrary, anti-apoptotic pathway, such as PI3K/Akt pathway, is simultaneously exploited by EV71 to accomplish the viral life cycle. The relationship by which EV71-induced apoptosis and PI3K/Akt signaling pathway remains to be elucidated. In this study, we demonstrated that EV71 infection altered Bax conformation and triggered its redistribution from the cytosol to mitochondria in RD cells. Subsequently, cytochrome c was released from mitochondria to cytosol. We also found that c-Jun NH2-terminal kinase (JNK) was activated during EV71 infection. The JNK specific inhibitor significantly inhibited Bax activation and cytochrome c release, suggesting that EV71-induced apoptosis was involved into a JNK-dependent manner. Meanwhile, EV71-induced Akt phosphorylation involved a PI3K-dependent mechanism. Inhibition of the PI3K/Akt pathway enhanced JNK phosphorylation and the JNK-mediated apoptosis upon EV71 infection. Moreover, PI3K/Akt pathway phosphorylated apoptosis signal-regulating kinase 1 (ASK1) and negatively regulated the ASK1 activity. Knockdown of ASK1 significantly decreased JNK phosphorylation, which implied that ASK1 phosphorylation by Akt inhibited ASK1-mediated JNK activation. Collectively, these data reveal that activation of the PI3K/Akt pathway limits JNK-mediated apoptosis by phosphorylating and inactivating ASK1 during EV71 infection.

  15. Characterization of the antibody response against EV71 capsid proteins in Chinese individuals by NEIBM-ELISA

    OpenAIRE

    Ding, Yingying; Chen, Xuguang; Qian, Baohua; Wu, Guorong; He, Ting; Feng, Jiaojiao; Gao, Caixia; Wang, Lili; Wang, Jinhong; Li, Xiangyu; Cao, Mingmei; Peng, Heng; Zhao, Chunyan; Pan, Wei

    2015-01-01

    Human enterovirus 71 (EV71) has become the major pathogen of hand, foot, and mouth disease (HFMD) worldwide, while the anti-EV71 antibody responses other than neutralizing epitopes have not been characterized. In this study, EV71 capsid proteins VP1, VP3, VP0 and various VP1 antigens were constructed to analyze anti-EV71 response in severe HFMD cases, non-HFMD outpatient children and normal adults using a novel evolved immunoglobulin-binding molecule (NEIBM)-based ELISA. The high prevalence o...

  16. Characterization of the antibody response against EV71 capsid proteins in Chinese individuals by NEIBM-ELISA.

    Science.gov (United States)

    Ding, Yingying; Chen, Xuguang; Qian, Baohua; Wu, Guorong; He, Ting; Feng, Jiaojiao; Gao, Caixia; Wang, Lili; Wang, Jinhong; Li, Xiangyu; Cao, Mingmei; Peng, Heng; Zhao, Chunyan; Pan, Wei

    2015-01-01

    Human enterovirus 71 (EV71) has become the major pathogen of hand, foot, and mouth disease (HFMD) worldwide, while the anti-EV71 antibody responses other than neutralizing epitopes have not been characterized. In this study, EV71 capsid proteins VP1, VP3, VP0 and various VP1 antigens were constructed to analyze anti-EV71 response in severe HFMD cases, non-HFMD outpatient children and normal adults using a novel evolved immunoglobulin-binding molecule (NEIBM)-based ELISA. The high prevalence of antibody responses against all three capsid proteins was demonstrated, and anti-EV71 VP1 showed the main antibody response. Anti-EV71 VP1 antibody response was found to predominantly target to epitopes based on the common enterovirus cross-reactive sequence. Moreover, inhibition pattern against anti-EV71 VP1 reactions in three groups was obviously different. Taken together, these results firstly characterized the anti-EV71 antibody responses which are predominantly against VP1 epitopes based on common enterovirus cross-reactive sequence. This finding could be helpful for the better understanding of anti-EV71 humoral immunity and useful for seroepidemiological surveillance.

  17. Coordinated EV adoption: double-digit reductions in emissions and fuel use for $40/vehicle-year.

    Science.gov (United States)

    Choi, Dong Gu; Kreikebaum, Frank; Thomas, Valerie M; Divan, Deepak

    2013-09-17

    Adoption of electric vehicles (EVs) would affect the costs and sources of electricity and the United States efficiency requirements for conventional vehicles (CVs). We model EV adoption scenarios in each of six regions of the Eastern Interconnection, containing 70% of the United States population. We develop electricity system optimization models at the multidecade, day-ahead, and hour-ahead time scales, incorporating spatial wind energy modeling, endogenous modeling of CV efficiencies, projections for EV efficiencies, and projected CV and EV costs. We find two means to reduce total consumer expenditure (TCE): (i) controlling charge timing and (ii) unlinking the fuel economy regulations for CVs from EVs. Although EVs provide minimal direct GHG reductions, controlled charging provides load flexibility, lowering the cost of renewable electricity. Without EVs, a 33% renewable electricity standard (RES) would cost $193/vehicle-year more than the reference case (10% RES). Combining a 33% RES, EVs with controlled charging and unlinking would reduce combined electric- and vehicle-sector CO2 emissions by 27% and reduce gasoline consumption by 59% for $40/vehicle-year more than the reference case. Coordinating EV adoption with adoption of controlled charging, unlinked fuel economy regulations, and renewable electricity standards would provide low-cost reductions in emissions and fuel usage.

  18. EV71-2A突变质粒的构建及体内外功能初探%Construction of pcDNA3 . 1-EV71-2A mutant and preliminary studying related biological functions

    Institute of Scientific and Technical Information of China (English)

    原素梅; 徐超; 张煦; 王源; 谢冰玉; 熊庆; 彭宜红

    2016-01-01

    Objective To construct EV71-2Amut(pcDNA3. 1-EV71-2A mutant plasmid)and studying its functions in vitro and in vivo, so as to provide an experiemental base for the further studying the active site and biological function of 2A pro-teinase. Methods By using of site-directed mutagenesis system based on PCR, EV71-2Amut was constructed on site-directed mutagenesis of 21His,39Asp and 110Cys genes and confirmed by sequencing analysis. Then EV71-2Amut and pRL-CMV(Cyto-megalovirus, CMV) were co-transfected to human rhabdomyosarcoma cell( RD cell) , and the enzyme activity inside cells was determined and compared with effect to pRL expression level between wild type EV71-2Apro and EV71-2Amut . EV71-2A mR-NA was detected by RT-PCR, and its effect on the quadriceps femoris of BALB/c mice was observed on histopathological changes, which reflected its transcription level and activity in vivo. Results The constructed EV71-2Amut sequence was i-dentical with we expected,the RL activity detected at cellular level from EV71-2Amut groups were significantly higher than that of EV71-2Apro groups (P<0. 05). EV71-2A-mRNA were detected by RT-PCR in quadriceps femoris from the mice injected with EV71-2Apro and EV71-2Amut . Compared with the control group injected with wild type 2A,inflammatory cell infiltration and coagulation necrosis were mild in quadriceps femoris injected with EV71-2Amut . Conclusion EV71-2Amut with H21N+D39E+C110A was successfully constructed. and its protease activity was almost abolished in RD cell and BABL/c mice. This work provides a ground work for the further studying the biological functions of EV71-2A protease.%目的:构建pcDNA3.1-EV71-2A的突变质粒(EV71-2Amut),并对其功能进行检测,为进一步研究肠道病毒71型(Enterovirus type 71,EV71)2A蛋白酶的活性位点及其生物学功能奠定实验基础。方法利用聚合酶链式反应(PCR)定点诱变技术,定点突变编码EV71-2A第21His、39Asp 和110Cys 氨基酸的位点,构建EV71

  19. A study of errors in trajectory simulation with relevance for 0.2-50 eV electrons in liquid water

    International Nuclear Information System (INIS)

    A highly simplified model of the elastic scattering of electrons in a nm-size volume of liquid water, where the water molecules are regarded as point scatterers and inelastic scattering is neglected, is studied for electron energies 0.2-50 eV. This model allows an exact quantum mechanical solution of the multiple elastic scattering problem. The exact solutions are compared with the corresponding trajectory simulations. Two different data sets for the elastic scattering mean free path are discussed and used, one based on cross sections for water molecules in the gas phase and the other on cross sections derived from scattering in amorphous ice. In each case, the comparison provides a detailed insight into the character and magnitude of the error in the trajectory simulation, and gives a preliminary indication of an upper bound to the limits of validity of trajectory simulation in the real case of electron scattering in liquid water. Main results: with a fully random distribution of scatterers, the trajectory simulation is found to be a surprisingly good approximation down to quite low electron energies (∼10eV). Below a few eV, the error increases rapidly with decreasing electron energy. A substantial increase of the error in trajectory simulation results when short-range order (minimum distance between scatterers) is introduced; the observed effect may partly be understood from the theory of kinematic diffraction in liquids. At very low electron energies (a few eV) one may note a quantum effect in the form of a standing wave pattern in the average distribution of scattering events

  20. Technology Roadmaps - Electric and plug-in hybrid electric vehicles (EV/PHEV)

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2011-06-15

    The mass deployment of electric and plug-in hybrid electric vehicles (EVs and PHEVs) that rely on low greenhouse gas (GHG) emission electricity generation has great potential to significantly reduce the consumption of petroleum and other high CO2-emitting transportation fuels. The vision of the Electric and Plug-in Hybrid (EV/PHEV) Vehicles Roadmap is to achieve by 2050 the widespread adoption and use of EVs and PHEVs, which together represent more than 50% of annual LDV (light duty vehicle) sales worldwide. In addition to establishing a vision, this roadmap sets strategic goals to achieve it, and identifies the steps that need to be taken to accomplish these goals. This roadmap also outlines the roles and collaboration opportunities for different stakeholders and shows how government policy can support the overall achievement of the vision. The strategic goals for attaining the widespread adoption and use of EVs and PHEVs worldwide by 2050 cover the development of the EV/PHEV market worldwide through 2030 and involve targets that align with global targets to stabilise GHG concentrations. These technology-specific goals include the following: Set targets for electric-drive vehicle sales; Develop coordinated strategies to support the market introduction of electric-drive vehicles; Improve industry understanding of consumer needs and behaviours; Develop performance metrics for characterising vehicles; Foster energy storage RD and D initiatives to reduce costs and address resource-related issues; and, Develop and implement recharging infrastructure. The roadmap outlines additional recommendations that must be considered in order to successfully meet the technology milestones and strategic goals. These recommendations include the following: Use a comprehensive mix of policies that provide a clear framework and balance stakeholder interests; Engage in international collaboration efforts; and, Address policy and industry needs at a national level. The IEA will work in an

  1. Supernova 2010ev: A reddened high velocity gradient type Ia supernova

    Science.gov (United States)

    Gutiérrez, Claudia P.; González-Gaitán, Santiago; Folatelli, Gastón; Pignata, Giuliano; Anderson, Joseph P.; Hamuy, Mario; Morrell, Nidia; Stritzinger, Maximilian; Taubenberger, Stefan; Bufano, Filomena; Olivares E., Felipe; Haislip, Joshua B.; Reichart, Daniel E.

    2016-05-01

    Aims: We present and study the spectroscopic and photometric evolution of the type Ia supernova (SN Ia) 2010ev. Methods: We obtain and analyze multiband optical light curves and optical/near-infrared spectroscopy at low and medium resolution spanning -7 days to +300 days from the B-band maximum. Results: A photometric analysis shows that SN 2010ev is a SN Ia of normal brightness with a light-curve shape of Δm15(B) = 1.12 ± 0.02 and a stretch s = 0.94 ± 0.01 suffering significant reddening. From photometric and spectroscopic analysis, we deduce a color excess of E(B - V) = 0.25 ± 0.05 and a reddening law of Rv = 1.54 ± 0.65. Spectroscopically, SN 2010ev belongs to the broad-line SN Ia group, showing stronger than average Si iiλ6355 absorption features. We also find that SN 2010ev is a high velocity gradient SN with v˙Si = 164 ± 7 km s-1 d-1. The photometric and spectral comparison with other supernovae shows that SN 2010ev has similar colors and velocities to SN 2002bo and SN 2002dj. The analysis of the nebular spectra indicates that the [Fe ii]λ7155 and [Ni ii]λ7378 lines are redshifted, as expected for a high velocity gradient supernova. All these common intrinsic and extrinsic properties of the high velocity gradient (HVG) group are different from the low velocity gradient (LVG) normal SN Ia population and suggest significant variety in SN Ia explosions. This paper includes data gathered with the Du Pont Telescope at Las Campanas Observatory, Chile; and the Gemini Observatory, Cerro Pachon, Chile (Gemini Program GS-2010A-Q-14). Based on observations collected at the European Organisation for Astronomical Research in the Southern Hemisphere, Chile (ESO Programme 085.D-0577).

  2. Magnetic Field Generation and Energy Confinement with Te> 500 eV in the SSPX Spheromak

    Science.gov (United States)

    Hudson, B.

    2007-11-01

    The understanding of confinement and energy transport in spheromaks is key the understanding the physics of spheromak formation and self-organization as well as addressing the feasibility of the concept as a reactor scenario. In the Sustained Spheromak Physics eXperiment (SSPX), increased understanding of the physics in building and sustaining self-organized magnetic equilibria has resulted in record electron temperatures Te> 500 eV and plasma currents of ˜ 1 MA on the magnetic axis. We find that the highest edge magnetic field magnitudes (and correspondingly high Te) is achieved when λ=μ0Igun ψgun is near (but slightly below) the Kruskal-Shafranov instability limit λKS2πL12.6,-1 where L is the length of the flux-conserver (0.5 m). Building on previously reported results, power-balance analysis has shown levels of electron thermal transport χebank we are able to highly tailor the gun current to take advantage of the sensitive dependence of spheromak performance on the plasma λ. When in this optimum operating range we also find that the efficiency of field build-up (defined as the ratio of edge poloidal magnetic field to gun current) is increased 20% over prior results, to ˜1.0 T/MA. Additionally this brings the efficiency of spheromak formation into numerical agreement with results from the NIMROD 3-D MHD code. Plasma energy evolution has been studied by taking time-resolved measurements of Te(r) and ne(r) indicating a distinct and robust feature of spheromak formation; a hollow-to-peaked temperature transition with an inverse relationship to the electron density. This feature, as well as sub-microsecond transport, is being studied with the upgrade of the Thomson scattering diagnostic to double-pulse operation. We also present recent results of the impact of charge-exchange losses on overall power balance and estimates of the plasma ion temperature as measured with a neutral particle analyzer.

  3. Low-energy (<20 eV) and high-energy (1000 eV) electron-induced methanol radiolysis of astrochemical interest

    Science.gov (United States)

    Sullivan, Kristal K.; Boamah, Mavis D.; Shulenberger, Katie E.; Chapman, Sitara; Atkinson, Karen E.; Boyer, Michael C.; Arumainayagam, Christopher R.

    2016-07-01

    We report the first infrared study of the low-energy (benefit that it does not require thermal processing prior to product detection. Using IRAS, we have found evidence for the formation of ethylene glycol (HOCH2CH2OH), formaldehyde (CH2O), dimethyl ether (CH3OCH3), methane (CH4), carbon dioxide (CO2), carbon monoxide (CO), and the hydroxyl methyl radical (·CH2OH) upon both low-energy and high-energy electron irradiation of condensed methanol at ˜85 K. Additionally, TPD results, presented herein, are similar for methanol films irradiated with both 1000 eV and 20 eV electrons. These IRAS and TPD findings are qualitatively consistent with the hypothesis that high-energy condensed phase radiolysis is mediated by low-energy electron-induced reactions. Moreover, methoxymethanol (CH3OCH2OH) could serve as a tracer molecule for electron-induced reactions in the interstellar medium. The results of experiments such as ours may provide a fundamental understanding of how complex organic molecules are synthesized in cosmic ices.

  4. Time-Resolved UV-Pump (4.8eV) and Vacuum-UV (8eV) Probe Experiments of Neutral Excited State Dynamics

    Science.gov (United States)

    Horton, Spencer; Liu, Yusong; Matsika, Spiridoula; Weinacht, Thomas

    2016-05-01

    Excited state dynamics in polyatomic molecules involve a rich mixture of internal conversion, intersystem crossing, isomerization, and dissociation. Probing these dynamics with ultrafast laser pulses poses a number of challenges, in terms of both the execution of the measurements and their interpretation. We have developed an apparatus for probing excited state dynamics using a 260nm UV-pump pulse and a 156nm Vacuum-UV (VUV) probe pulse. For many systems of interest, an 8eV probe pulse can ionize the molecule from essentially any position along the excited state potential, while not having a background ionization yield from the ground state. Furthermore, given the perturbative interaction of each pulse with the molecule, it is possible interpret and model the experimental results with greater ease and confidence than more complicated probe interactions such as strong field ionization. We compare UV-IR strong-field ionization pump-probe experiments previously conducted directly with our 8eV probing and explore the differences between the two.

  5. The value of EV71-IgM detection in diagnosis of hand foot mouth disease%EV71-IgM检测在手足口病诊断中的价值

    Institute of Scientific and Technical Information of China (English)

    刘金亭; 刘力建

    2016-01-01

    Objective:To evaluate the role of detecting EV71-IgM antibody by colloidal method and EV71 virus by RT-PCR method in the early identification of severe hand-foot-mouth disease by retrospective analysis.Methods:1 252 suspected cases of hand-foot-mouth disease were selected.The IgM antibody of EV71 intestinal virus was detected by serum colloidal gold method. The intestinal virus in stool of patients and 71-RNA were detected by RT-PCR method.Results:The positive rate of detecting EV71 by colloidal gold method was 28.67%;the positive rate of detecting intestinal virus by RT-PCR method was 81.15%;the positive rate of EV71 was 44.89%;5 cases were detected as positive by colloidal gold method and negative by RT-PCR method. Conclusion:EV71 colloidal gold method can be used as an early screening of EV71 infection,and it has important significance in early identification and treatment of severe hand-foot-mouth disease.%目的:回顾性分析评价应用胶体法检测EV71-IgM抗体与RT-PCR法检测EV71病毒在手足口病重症病例早期识别中的作用。方法:收治手足口病疑似病例1252例,分别采用血清胶体金法检测 EV71肠道病毒 IgM 抗体, RT-PCR法检测患者大便中肠道病毒及肠道病毒71-RNA。结果:胶体金法检测EV71阳性率28.67%;RT-PCR法检测肠道病毒阳性率81.15%,EV71阳性率44.89%。其中金标法检测阳性5例,RT-PCR法检测阴性。结论:EV71胶体金法可作为EV71感染的初筛早期快检,在临床手足口病重症病例早期识别及治疗中具有重要意义。

  6. 新型肠道病毒71型(EV71)疫苗质量控制和评价标准的研究%Quality Control and Evaluation of New Enterovirus 71 (EV71) Vaccines

    Institute of Scientific and Technical Information of China (English)

    毛群颖; 姚昕; 梁争论

    2012-01-01

    目的 研究建立新型肠道病毒71型(EV71)疫苗质量控制标准和评价体系,为EV71疫苗研发提供基础.方法 根据创新型疫苗研发的要求,充分发挥技术优势,开展EV71疫苗质控标准、标准品和评价方法研究.结果与结论 建立EV71灭活疫苗的中和抗体和抗原定量测定标准品,统一不同企业疫苗的质控标准,规范疫苗的评价体系,为EV71疫苗的研发提供保障.

  7. Simultaneous removal of NOX and SO2 from flue gases by energizing gases with electrons having energy in the range from 5 eV to 20 eV

    International Nuclear Information System (INIS)

    These notes report the results obtained with an experimental installation able to treat 100 Nm3/h of flue gases, installed at the Thermoelectrical Power Plant at Marghera. The experimental installation, operating on the principle of gas energizing, is able to remove simultaneously 40 to 50% of the NOX and about 100% of the SO2 contained in the flue gases. It is expected to achieve better efficiency in the removal of NOX by including in the system a bag filter which should favour removal reaction in the heterogeneous phase of NOX. Particulate concentration at output is between 2 and 5 mg/Nm3. A pulse generator designed and built by Enel was tested; the results were excellent, so work has begun on the preliminary planning of a 200 kW pulse generator that operates on the same principle. (author)

  8. Fission cross section measurements of Cm-247, Cf-250 and Es-254 from 0.1 eV to 80 keV

    International Nuclear Information System (INIS)

    Fission cross section measurements were made with the RINS system over the neutron energy range from approximately 0.1 eV to 80 keV upon samples of Cm-247, Cf-250 and Es-254. The Cm-247 measurement was undertaken to complete the RINS fission cross section measurement sequence of the curium isotopes, Es-254 was measured because it is a very heavy odd-odd nucleus which might show interesting nuclear structure effects in its fission cross section, and Cf-250 was measured to account for its buildup as a daughter product from the 276-day halflife Es-254. 6 refs., 3 figs

  9. Characterization of a quasi-sinusoidal transmission grating without membrane substrate in the 200-1500 eV photon energy regions

    Science.gov (United States)

    Wang, Chuanke; Wang, Baoqing; Yi, Tao; Fan, Quanping; Kuang, Longyu; Li, Jin; Li, Tingshuai; Zhu, Xiaoli; Liu, Shenye; Jiang, Gang

    2016-02-01

    A 1000-line/mm quasi-sinusoidal transmission grating (QSTG) without membrane substrate has been designed and fabricated, which is utilized to eliminate the higher order diffraction for soft X-ray spectrum measurement in the experiments of inertial confinement fusion. The grating was calibrated using an X-ray beam on synchrotron radiation facility. It shows that the QSTG has the desired diffraction property and the higher order diffraction components are efficiently suppressed in the photon energy ranges from 200 to 1500 eV.

  10. Total Cross Sections for Electron Scattering on Polyatomic Molecules (CH4, CO2,NO2, and N2O) at 10 ~ 3000 eV

    Institute of Scientific and Technical Information of China (English)

    SUN Jin-Feng; XU Bin; LIU Yu-Fang; SHI De-Heng

    2005-01-01

    A new modified formulation of the Additivity Rule (AR) was proposed to calculate the total electron scattering cross sections for CH4, CO2, NO2, and N2O, considering the overlapping between atoms in molecules and the not fully transparency of the molecules. The present calculation covers the range of impact energy from 10 to 3000 eV. The results are compared with experimental data and other theories where available. The atoms are presented by spherical complex optical potential, which is composed of static, exchange, polarization, and absorption terms.

  11. Absolute total cross sections for the scattering of 2--18-eV electrons by cesium atoms

    International Nuclear Information System (INIS)

    Absolute total cross sections for the scattering of electrons by cesium atoms between 2 and 18 eV have been measured using the atomic-recoil technique in the scattering-out mode. Our results are somewhat lower than those of Visconti, Slevin, and Rubin [Phys. Rev. A 3, 1310 (1971)] above 2 eV

  12. Absolute total cross sections for the scattering of 2--18-eV electrons by cesium atoms

    Energy Technology Data Exchange (ETDEWEB)

    Jaduszliwer, B.; Chan, Y.C. (Electronics Technology Center, The Aerospace Corporation, P. O. Box 92957, Los Angeles, California 90009 (United States))

    1992-01-01

    Absolute total cross sections for the scattering of electrons by cesium atoms between 2 and 18 eV have been measured using the atomic-recoil technique in the scattering-out mode. Our results are somewhat lower than those of Visconti, Slevin, and Rubin (Phys. Rev. A 3, 1310 (1971)) above 2 eV.

  13. Elevated expression of circulating miR876-5p is a specific response to severe EV71 infections.

    Science.gov (United States)

    Wang, Robert Y L; Weng, Kuo-Feng; Huang, Yhu-Chering; Chen, Chih-Jung

    2016-01-01

    Human enterovirus 71 (EV71) is a major causative agent of hand, foot, and, mouth disease, accounting for more than 65% of recent outbreaks. Following enteroviral infection, the host responses are crucial indicators for the development of a diagnosis regarding the clinical severity of EV71 infections. In this study, we implemented NanoString nCounter technology to characterize the responses of serum microRNA (miRNA) profiles to various EV71 infection diseases. Upon EV71 infection, 44 miRNAs were observed in patients with EV71 infections, with at least a 2-fold elevation and 133 miRNAs with a 2-fold reduction compared with the same miRNAs in healthy controls. Further detailed work with miR876-5p, a 9.5-fold change of upregulated miR-876-5p expression was observed in cases with severe EV71 symptoms, revealed that in vitro and in vivo knockdown of miR876-5p reduced viral RNA in cultured cells, and attenuated the severity of symptoms in EV71-infected mice. Altogether, we demonstrated that the elevated expression of circulating miR876-5p is a specific response to severe EV71 infections. PMID:27052555

  14. Enterovirus71 (EV71) utilise host microRNAs to mediate host immune system enhancing survival during infection.

    Science.gov (United States)

    Lui, Yan Long Edmund; Tan, Tuan Lin; Woo, Wee Hong; Timms, Peter; Hafner, Louise Marie; Tan, Kian Hwa; Tan, Eng Lee

    2014-01-01

    Hand, Foot and Mouth Disease (HFMD) is a self-limiting viral disease that mainly affects infants and children. In contrast with other HFMD causing enteroviruses, Enterovirus71 (EV71) has commonly been associated with severe clinical manifestation leading to death. Currently, due to a lack in understanding of EV71 pathogenesis, there is no antiviral therapeutics for the treatment of HFMD patients. Therefore the need to better understand the mechanism of EV71 pathogenesis is warranted. We have previously reported a human colorectal adenocarcinoma cell line (HT29) based model to study the pathogenesis of EV71. Using this system, we showed that knockdown of DGCR8, an essential cofactor for microRNAs biogenesis resulted in a reduction of EV71 replication. We also demonstrated that there are miRNAs changes during EV71 pathogenesis and EV71 utilise host miRNAs to attenuate antiviral pathways during infection. Together, data from this study provide critical information on the role of miRNAs during EV71 infection.

  15. EV71-IgM胶体金法在手足口病早期诊断的价值

    Institute of Scientific and Technical Information of China (English)

    甘超

    2013-01-01

    目的:评价胶体法检测EV71 IgM抗体与RT-PCR法检测EV71病毒核酸在手足口病诊断的优劣.方法:标本选取248例手足口疑似病例,分别采用血清金标法检测EV71肠道病毒IgM抗体,咽拭RT-PCR法检测EV71-RNA.结果:2012年3月~2012年4月对248例疑似病例进行胶体金法检测,EV71阳性率为16.94%(42/248),RT-PCR法检测阳性率为19.35%(48/248).其中2例金标法检测阳性采用RT-PCR法检测为阴性.EV71胶体金法快速检测试剂的特异度为96.15%,灵敏度为83.33%.结论:EV71胶体金法可作为EV71感染的初筛早期快检,在临床诊治和流感爆发疫情处理上具有重要意义.

  16. Elevated expression of circulating miR876-5p is a specific response to severe EV71 infections.

    Science.gov (United States)

    Wang, Robert Y L; Weng, Kuo-Feng; Huang, Yhu-Chering; Chen, Chih-Jung

    2016-01-01

    Human enterovirus 71 (EV71) is a major causative agent of hand, foot, and, mouth disease, accounting for more than 65% of recent outbreaks. Following enteroviral infection, the host responses are crucial indicators for the development of a diagnosis regarding the clinical severity of EV71 infections. In this study, we implemented NanoString nCounter technology to characterize the responses of serum microRNA (miRNA) profiles to various EV71 infection diseases. Upon EV71 infection, 44 miRNAs were observed in patients with EV71 infections, with at least a 2-fold elevation and 133 miRNAs with a 2-fold reduction compared with the same miRNAs in healthy controls. Further detailed work with miR876-5p, a 9.5-fold change of upregulated miR-876-5p expression was observed in cases with severe EV71 symptoms, revealed that in vitro and in vivo knockdown of miR876-5p reduced viral RNA in cultured cells, and attenuated the severity of symptoms in EV71-infected mice. Altogether, we demonstrated that the elevated expression of circulating miR876-5p is a specific response to severe EV71 infections.

  17. Minnesota Pheasant Range

    Data.gov (United States)

    Minnesota Department of Natural Resources — This dataset delineates the spatial range of wild pheasant populations in Minnesota as of 2002 by dividing the MN state boundary into 2 units: pheasant range and...

  18. Telemetry Ranging: Concepts

    Science.gov (United States)

    Hamkins, J.; Kinman, P.; Xie, H.; Vilnrotter, V.; Dolinar, S.

    2015-11-01

    Telemetry ranging is a proposed alternative to conventional two-way ranging for determining the two-way time delay between a Deep Space Station (DSS) and a spacecraft. The advantage of telemetry ranging is that the ranging signal on the uplink is not echoed to the downlink, so that telemetry alone modulates the downlink carrier. The timing information needed on the downlink, in order to determine the two-way time delay, is obtained from telemetry frames. This article describes the phase and timing estimates required for telemetry ranging, and how two-way range is calculated from these estimates. It explains why the telemetry ranging architecture does not require the spacecraft transponder to have a high-frequency or high-quality oscillator, and it describes how a telemetry ranging system can be infused in the Deep Space Network.

  19. Optimising production using the state-contingent approach versus the EV approach

    DEFF Research Database (Denmark)

    Rasmussen, Svend

    It is not clear whether the state-contingent approach to decision making under risk and uncertainty has the potential of providing better decisions than the well-known EV model based on an estimated stochastic production function and variance measures. The paper uses Monte Carlo simulation...... to analyse this question. Based on an artificially generated set of stochastic production data, parameters of both stochastic production functions and of state-contingent production functions are estimated. Using these estimated production functions, input decisions are afterwards optimised using three...... different types of utility functions, i.e. linear utility function, EV-utility function and a Cobb Douglas utility function based on state-contingent income measures. Monte Carlo simulation is carried out for various numbers of observations. Finally the results are compared to the true optimal choice...

  20. Efficient determination of distribution tariffs for the prevention of congestion from EV Charging

    DEFF Research Database (Denmark)

    O'Connell, Niamh; Wu, Qiuwei; Østergaard, Jacob

    2012-01-01

    into the day-ahead market. The DT acts to disperse charging at congested periods and locations, thereby preventing congestion on a day-ahead basis. The magnitude of the DT is determined from a simulated locational marginal prices (LMPs), and the time extent of the DT is determined from analysis of the system...... is highly efficient at grid congestion prevention, and the precise level of congestion that can be alleviated is dependent on the price profile of the optimisation period in question.......A dual objective electric vehicle (EV) charging schedule optimisation is proposed here whereby both consumer driving requirements and grid constraints are respected. A day-ahead dynamic tariff (DT) for distribution systems is proposed as a price signal to EV fleet operators (FO) bidding...

  1. Optimal Operation of EVs and HPs in the Nordic Power System

    DEFF Research Database (Denmark)

    Liu, Zhaoxi

    is consistent with the environmental weather pro- files. The increasing HP demand in the evening coincides with the conventional peak hours of the power system which may stress the grid. A chance constrained programming model through mixed-integer programming (MIP) is proposed to formulate the EV demand......The Nordic countries, including Denmark, Finland, Norway and Sweden, have great ambitions in seeking a fully carbon neutral or low-carbon electric power system by 2050. The large scale deployment of electric vehicles (EVs) and heat pumps (HPs) is considered not only as an efficient method to limit...... the greenhouse gas (GHG) emission and the fossil fuel consumption in the transportation and heating sectors but also as a potential approach to cope with the intermittency due to the further utilization of renewable energy sources (RES) in the Nordic region. With increasing amounts of RES in the power system...

  2. Intense X-ray flares from active stellar systems - EV Lacertae and HD 8357

    Science.gov (United States)

    Ambruster, C.; Snyder, W. A.; Wood, K. S.

    1984-01-01

    The HEAO A-1 Sky Survey Experiment included X-ray data used to define light curves for the flare star EV Lac and for X-ray flares observed in the binary system HD 8357. The data were taken during flare events and were detailed enough to calculate the flare rates and flaring luminosities. The peak luminosities during flares were several times the luminosities in normal X-ray flares emitted by the objects. Peak luminosities reached 30-50 times the normal variations and were associated with an order of magnitude increase in energy output. EV Lac was sufficiently active to be recommended for inclusion in future X-ray monitoring programs.

  3. Gain ranging amplifier

    International Nuclear Information System (INIS)

    A gain ranging amplifier system is provided for use in the acquisition of data. Voltage offset compensation is utilized to correct errors in the gain ranging amplifier system caused by thermal drift and temperature dependent voltage offsets, both of which are associated with amplifiers in the gain ranging amplifier system

  4. On the Transition Improvement of EV or HEV Induction Motor Propulsion Sensor Fault-Tolerant Controller

    OpenAIRE

    Tabbache, Bekheira; Benbouzid, Mohamed; Kheloui, Abdelaziz

    2010-01-01

    International audience This technical paper deals with the transition performance improvement of a sensor fault-tolerant controller devoted to Electric (EV) or Hybrid Electric Vehicles (HEV). Indeed, improvements are brought over a previously developed technique that exhibit abrupt changes in the torque if a sensor fault is detected and after a transition from a control technique to another one [1]. The Fault-Tolerant Control (FTC) system firstly concerns the sliding mode control technique...

  5. Picosecond x-ray measurements from 100 eV to 30 keV

    International Nuclear Information System (INIS)

    Picosecond x-ray measurements relevant to the Livermore Laser Fusion Program are reviewed. Resolved to 15 picoseconds, streak camera detection capabilities extend from 100 eV to higher than 30 keV, with synchronous capabilities in the visible, near infrared, and ultraviolet. Capabilities include automated data retrieval using charge coupled devices (CCD's), absolute x-ray intensity levels, novel cathodes, x-ray mirror/reflector combinations, and a variety of x-ray imaging devices

  6. Picosecond x-ray measurements from 100 eV to 30 keV

    Energy Technology Data Exchange (ETDEWEB)

    Attwood, D.T.; Kauffman, R.L.; Stradling, G.L.

    1980-10-15

    Picosecond x-ray measurements relevant to the Livermore Laser Fusion Program are reviewed. Resolved to 15 picoseconds, streak camera detection capabilities extend from 100 eV to higher than 30 keV, with synchronous capabilities in the visible, near infrared, and ultraviolet. Capabilities include automated data retrieval using charge coupled devices (CCD's), absolute x-ray intensity levels, novel cathodes, x-ray mirror/reflector combinations, and a variety of x-ray imaging devices.

  7. 20 Jahre ‚Gäa e.V. - Vereinigung ökologischer Landbau’

    OpenAIRE

    Wolf, Dipl.-Ing. agr. D.; Hirte, Dr. K.; Schüler, Dr. C.; Heß, Prof. Dr. J.

    2009-01-01

    For the understanding of ecological agriculture, knowledge of its roots is essential. Actual literature about this topic does not cover the history of ecological agriculture in East Germany especially if chronological development and individual motivation are seen as mutual dependent. The ecological organisation Gäa e.V. was founded in the GDR in 1989. Its origins were oppositional environmental groups working within the East German church. It developed own principles based on ...

  8. Shower front structure in EAS, Esub(p) approximately 3 x 1017 eV

    International Nuclear Information System (INIS)

    It is necessary to invoke a fast-developing air shower model to interpret the measurements of signal rise-times observed at about 500 m from the axis of extensive air showers (EAS) with primary energy near 3 x 1017 eV. Fluctuations in these rise-times indicate that the primary cosmic rays at this energy consist of at least 40 % protons. (author)

  9. Teadus- ja erialaraamatukogudel oma päev ja aasta teo auhind / Kristina Rallmann

    Index Scriptorium Estoniae

    Rallmann, Kristina

    2008-01-01

    Esimene teadus- ja erialaraamatukogude päev toimus 22. oktoobril 2008 Tallinna majanduskoolis, teadusraamatukogu aasta teo auhind läks RR-i virtuaaalnäitusele "Meie parlament ja aeg: fakte, sündmusi, dokumente, inimesi" ning erialaraamatukogu aasta teo auhind Eesti Pimedate Raamatukogu töörühmale heliteavikute CD-plaatidele automatiseeritud paljundamise ja posti teel laenutamise süsteemi eest

  10. Tallinki esimene börsipäev pettis väikeinvestorite ootusi / Hindrek Riikoja

    Index Scriptorium Estoniae

    Riikoja, Hindrek

    2005-01-01

    Tallinki aktsia esimene börsipäev valmistas paljudele väikeinvestoritele pettumust, kuna aktsia hind tõusis päevaga vaid 58 senti ehk 0,7 protsenti. Lisa: Kas teate? Küsimusele, mida teete Tallinki aktsiatega, vastavad: ettevõtja Indrek Toome, Riigikogu liige Margus Hanson, teleprodutsent Raivo Suviste ja AS-i Biodiesel nõukogu esimees Heino Harak

  11. Immunogenicity and protective efficacy of an EV71 virus-like particle vaccine against lethal challenge in newborn mice.

    Science.gov (United States)

    Sun, Shiyang; Gao, Fan; Mao, Qunying; Shao, Jie; Jiang, Liping; Liu, Dawei; Wang, Yiping; Yao, Xin; Wu, Xing; Sun, Bo; Zhao, Dandan; Ma, Youlei; Lu, Jingcai; Kong, Wei; Jiang, Chunlai; Liang, Zhenglun

    2015-01-01

    Enterovirus 71(EV71) has caused severe epidemics of hand, foot and mouth disease (HFMD) in the Asia Pacific in recent years, particularly in infants and pre-school children. It has become a serious public health threat, as currently there are no approved vaccines or antiviral drugs for EV71 infection. Many EV71 vaccines have been under development worldwide, however the main focus is inactivated EV71 vaccines. For example, the inactivated EV71 vaccine has recently finished phase III clinical trial in Mainland China. There have been very few studies on EV71 virus like particles (VLPs). In this study, the immunogenicity and protective potency of the EV71 VLPs produced in insect cells were evaluated in mice with different dosages. Our results showed that EV71 VLPs could elicit high titers of neutralizing antibodies (NTAbs) in a dose-dependent manner and NTAbs were sustained after the second injection with an average GMT (geometric mean titer) level from 19 to 2960 in immunized mice. Survival rates were 100%, 100%, 85%, and 40% after challenge with 15 LD50 (median lethal dose) of EV71 in these newborn mice, respectively. ED50 (50% effective dose) of VLPs was 0.20 μg/dose in newborn mice, while NTAb titer under this dosage was about 50. Passive protection was determined with 2 methods and demonstrated that the survival rates were positively correlated with NTAb titers, which at 24 and 54 induced 50% survival rates in experimental animals. The ED50 of VLP vaccines and the passive NTAb titers were also analyzed. The maternal NTAb titer was similar as the passive NTAb titer in the mouse model challenged with our lethal mouse EV71 strain. Hence, our work has provided preliminary data on the protection potency of VLPs as a vaccine candidate and would facilitate future VLP vaccine development.

  12. High-kinetic-energy photoemission spectroscopy of Ni at 1s : 6-eV satellite at 4 eV

    Science.gov (United States)

    Karis, O.; Svensson, S.; Rusz, J.; Oppeneer, P. M.; Gorgoi, M.; Schäfers, F.; Braun, W.; Eberhardt, W.; Mårtensson, N.

    2008-12-01

    Electron correlations are responsible for many profound phenomena in solid-state physics. A classical example is the 6-eV satellite in the photoelectron spectrum of Ni. Until now the satellite structure has only been investigated at the L shell and more shallow levels. Here we report a high-kinetic-energy photoemission spectroscopy (HIKE) investigation of Ni metal. We present 1s and 2p photoelectron spectra, obtained using excitation energies up to 12.6 keV. Our investigation demonstrates that the energy position of the satellite relative to the main line is different for the 1s and the 2p levels. In combination with electronic structure calculations, we show that this energy shift is attributed to unique differences in the core-valence coupling for the K and L2,3 shells in 3d transition metals, resulting in different screening of the core holes.

  13. Distribution of EV71 receptors SCARB2 and PSGL-1 in human tissues.

    Science.gov (United States)

    Jiao, Xiao-Yang; Guo, Li; Huang, Dong-Yang; Chang, Xiao-Lan; Qiu, Qian-Cheng

    2014-09-22

    The aim of this study was to investigate the distribution of Enterovirus 71 (EV71) receptors SCARB2 and PSGL-1 in human tissues. The samples were chosen from archived specimens, and the profiles of two receptors were detected in the gastrointestinal tract, lung, and brain in situ by immunohistochemistry. SCARB2 was detected in all the tissues studied, and strong staining was observed in the gastric fundus gland, mucosal and glandular epithelia of the intestine. Similar expression was found in bronchial epithelia and pneumocytes. In addition, SCARB2 was observed in the esophagus/gastric mucosal epithelia, neuron, glial cells, and blood vessels and the perivascular tissues of the brain. By comparison, PSGL-1 was expressed weakly in the mucosal and glandular epithelia of the small intestine and colon. PSGL-1 was expressed in a few bronchial epithelia, and weak staining was observed in the pneumocytes. However, PSGL-1 was found easily in the lamina propria of all the tissues studied, and strong staining of PSGL-1 was also observed in the neurons and glial cells. The distribution of the SCARB2 and PSGL-1 in human gastrointestinal tract, lung, and brain tissues correlated with the distribution of pathological changes seen in EV71 infection. The widespread prevalence of these receptors may help explain the multiple organ involvement in infection with EV71. PMID:24997419

  14. Distribution of EV71 receptors SCARB2 and PSGL-1 in human tissues.

    Science.gov (United States)

    Jiao, Xiao-Yang; Guo, Li; Huang, Dong-Yang; Chang, Xiao-Lan; Qiu, Qian-Cheng

    2014-09-22

    The aim of this study was to investigate the distribution of Enterovirus 71 (EV71) receptors SCARB2 and PSGL-1 in human tissues. The samples were chosen from archived specimens, and the profiles of two receptors were detected in the gastrointestinal tract, lung, and brain in situ by immunohistochemistry. SCARB2 was detected in all the tissues studied, and strong staining was observed in the gastric fundus gland, mucosal and glandular epithelia of the intestine. Similar expression was found in bronchial epithelia and pneumocytes. In addition, SCARB2 was observed in the esophagus/gastric mucosal epithelia, neuron, glial cells, and blood vessels and the perivascular tissues of the brain. By comparison, PSGL-1 was expressed weakly in the mucosal and glandular epithelia of the small intestine and colon. PSGL-1 was expressed in a few bronchial epithelia, and weak staining was observed in the pneumocytes. However, PSGL-1 was found easily in the lamina propria of all the tissues studied, and strong staining of PSGL-1 was also observed in the neurons and glial cells. The distribution of the SCARB2 and PSGL-1 in human gastrointestinal tract, lung, and brain tissues correlated with the distribution of pathological changes seen in EV71 infection. The widespread prevalence of these receptors may help explain the multiple organ involvement in infection with EV71.

  15. Molecular mechanism of SCARB2-mediated attachment and uncoating of EV71.

    Science.gov (United States)

    Dang, Minghao; Wang, Xiangxi; Wang, Quan; Wang, Yaxin; Lin, Jianping; Sun, Yuna; Li, Xuemei; Zhang, Liguo; Lou, Zhiyong; Wang, Junzhi; Rao, Zihe

    2014-09-01

    Unlike the well-established picture for the entry of enveloped viruses, the mechanism of cellular entry of non-enveloped eukaryotic viruses remains largely mysterious. Picornaviruses are representative models for such viruses, and initiate this entry process by their functional receptors. Here we present the structural and functional studies of SCARB2, a functional receptor of the important human enterovirus 71 (EV71). SCARB2 is responsible for attachment as well as uncoating of EV71. Differences in the structures of SCARB2 under neutral and acidic conditions reveal that SCARB2 undergoes a pivotal pH-dependent conformational change which opens a lipid-transfer tunnel to mediate the expulsion of a hydrophobic pocket factor from the virion, a pre-requisite for uncoating. We have also identified the key residues essential for attachment to SCARB2, identifying the canyon region of EV71 as mediating the receptor interaction. Together these results provide a clear understanding of cellular attachment and initiation of uncoating for enteroviruses.

  16. Study of the integrated immune response induced by an inactivated EV71 vaccine.

    Directory of Open Access Journals (Sweden)

    Longding Liu

    Full Text Available UNLABELLED: Enterovirus 71 (EV71, a major causative agent of hand-foot-and-mouth disease (HFMD, causes outbreaks among children in the Asia-Pacific region. A vaccine is urgently needed. Based on successful pre-clinical work, phase I and II clinical trials of an inactivated EV71 vaccine, which included the participants of 288 and 660 respectively, have been conducted. In the present study, the immune response and the correlated modulation of gene expression in the peripheral blood mononuclear cells (PBMCs of 30 infants (6 to 11 months immunized with this vaccine or placebo and consented to join this study in the phase II clinical trial were analyzed. The results showed significantly greater neutralizing antibody and specific T cell responses in vaccine group after two inoculations on days 0 and 28. Additionally, more than 600 functional genes that were up- or down-regulated in PBMCs were identified by the microarray assay, and these genes included 68 genes associated with the immune response in vaccine group. These results emphasize the gene expression profile of the immune system in response to an inactivated EV71 vaccine in humans and confirmed that such an immune response was generated as the result of the positive mobilization of the immune system. Furthermore, the immune response was not accompanied by the development of a remarkable inflammatory response. CLINICAL TRIAL REGISTRATION: NCT01391494 and NCT01512706.

  17. A dominant EV71-specific CD4+ T cell epitope is highly conserved among human enteroviruses.

    Directory of Open Access Journals (Sweden)

    Ruicheng Wei

    Full Text Available CD4+ T cell-mediated immunity plays a central role in determining the immunopathogenesis of viral infections. However, the role of CD4+ T cells in EV71 infection, which causes hand, foot and mouth disease (HFMD, has yet to be elucidated. We applied a sophisticated method to identify promiscuous CD4+ T cell epitopes contained within the sequence of the EV71 polyprotein. Fifteen epitopes were identified, and three of them are dominant ones. The most dominant epitope is highly conserved among enterovirus species, including HFMD-related coxsackieviruses, HFMD-unrelated echoviruses and polioviruses. Furthermore, the CD4+ T cells specific to the epitope indeed cross-reacted with the homolog of poliovirus 3 Sabin. Our findings imply that CD4+ T cell responses to poliovirus following vaccination, or to other enteroviruses to which individuals may be exposed in early childhood, may have a modulating effect on subsequent CD4+ T cell response to EV71 infection or vaccine.

  18. Generating Geospatially Realistic Driving Patterns Derived From Clustering Analysis Of Real EV Driving Data

    DEFF Research Database (Denmark)

    Pedersen, Anders Bro; Aabrandt, Andreas; Østergaard, Jacob;

    2014-01-01

    In order to provide a vehicle fleet that realistically represents the predicted Electric Vehicle (EV) penetration for the future, a model is required that mimics people driving behaviour rather than simply playing back collected data. When the focus is broadened from on a traditional user-centric...... the vehicles park, the model can be transferred geographically using known locations of the same classification.......In order to provide a vehicle fleet that realistically represents the predicted Electric Vehicle (EV) penetration for the future, a model is required that mimics people driving behaviour rather than simply playing back collected data. When the focus is broadened from on a traditional user......-centric smart charging approach to be more grid-centric, it suddenly becomes important to know not just when- and how much the vehicles charge, but also where in the grid they plug in. Since one of the main goals of EV-grid studies is to find the saturation point, it is equally important that the simulation...

  19. Telemetry Ranging: Signal Processing

    Science.gov (United States)

    Hamkins, J.; Kinman, P.; Xie, H.; Vilnrotter, V.; Dolinar, S.

    2016-02-01

    This article describes the details of the signal processing used in a telemetry ranging system in which timing information is extracted from the downlink telemetry signal in order to compute spacecraft range. A previous article describes telemetry ranging concepts and architecture, which are a slight variation of a scheme published earlier. As in that earlier work, the telemetry ranging concept eliminates the need for a dedicated downlink ranging signal to communicate the necessary timing information. The present article describes the operation and performance of the major receiver functions on the spacecraft and the ground --- many of which are standard tracking loops already in use in JPL's flight and ground radios --- and how they can be used to provide the relevant information for making a range measurement. It also describes the implementation of these functions in software, and performance of an end-to-end software simulation of the telemetry ranging system.

  20. Telemetry-Based Ranging

    Science.gov (United States)

    Hamkins, Jon; Vilnrotter, Victor A.; Andrews, Kenneth S.; Shambayati, Shervin

    2011-01-01

    A telemetry-based ranging scheme was developed in which the downlink ranging signal is eliminated, and the range is computed directly from the downlink telemetry signal. This is the first Deep Space Network (DSN) ranging technology that does not require the spacecraft to transmit a separate ranging signal. By contrast, the evolutionary ranging techniques used over the years by NASA missions, including sequential ranging (transmission of a sequence of sinusoids) and PN-ranging (transmission of a pseudo-noise sequence) whether regenerative (spacecraft acquires, then regenerates and retransmits a noise-free ranging signal) or transparent (spacecraft feeds the noisy demodulated uplink ranging signal into the downlink phase modulator) relied on spacecraft power and bandwidth to transmit an explicit ranging signal. The state of the art in ranging is described in an emerging CCSDS (Consultative Committee for Space Data Systems) standard, in which a pseudo-noise (PN) sequence is transmitted from the ground to the spacecraft, acquired onboard, and the PN sequence is coherently retransmitted back to the ground, where a delay measurement is made between the uplink and downlink signals. In this work, the telemetry signal is aligned with the uplink PN code epoch. The ground station computes the delay between the uplink signal transmission and the received downlink telemetry. Such a computation is feasible because symbol synchronizability is already an integral part of the telemetry design. Under existing technology, the telemetry signal cannot be used for ranging because its arrival-time information is not coherent with any Earth reference signal. By introducing this coherence, and performing joint telemetry detection and arrival-time estimation on the ground, a high-rate telemetry signal can provide all the precision necessary for spacecraft ranging.

  1. Increasing the Cruise Range and Reducing the Capital Cost of Electric Vehicles by Integrating Auxiliary Unit with the Traction Drive

    OpenAIRE

    N. Satheesh Kumar

    2016-01-01

    Poor cruise performance of Electric Vehicles (EVs) continues to be the primary reason that impends their market penetration. Adding more battery to extend the cruise range is not a viable solution as it increases the structural weight and capital cost of the EV. Simulations identified that a vehicle spends on average 15% of its total time in braking, signifying an immense potential of the utilization of regenerative braking mechanism. Based on the analysis, a 3 kW auxiliary electrical unit co...

  2. Molecular identification of newer enterovirus EV93 in the species of HEV-B from Yunnan province%云南省新型肠道病毒EV93的分子生物学鉴定

    Institute of Scientific and Technical Information of China (English)

    田炳均; 陆林; 赵智娴; 张杰; 丁峥嵘

    2008-01-01

    人类肠道病毒(HEV)分为5个组别:HEV-A、HEV-B、HEV-C、HEV-D和脊髓灰质炎病毒(PV)。HEV-A由柯萨奇A2(CV-A2)-CV-A8、CV-A10、CV-A12、CV-A14、CV-A16、EV71和4种新型病毒EV76、Ev89、Ev90、EV91组成[1]。HEV-B由CV-A9、CV-B1-6、艾柯病毒(E)E1-7、E9、E11-21、E24-27、E29-33、EV69以及6个新发现的病毒EV73、

  3. EV71感染致重症手足口病的研究进展%Progress of severe hand-foot-mouth disease infected by EV71 virus

    Institute of Scientific and Technical Information of China (English)

    杨坤; 赵东赤

    2010-01-01

    肠道病毒71型(enterovirus 71,EV71)是人类肠道病毒的一种,近30年来,EV71感染在亚太地区广泛流行,是手足口病(HFMD)重症病例的主要病原体.EV71感染引起的重症HFMD病情进展迅速,可表现为中枢神经系统和呼吸系统受累,其发病机制目前尚不十分清楚.研究认为病毒首先通过神经通路侵犯中枢神经系统,导致中枢神经系统的并发症,严重的病例进一步发展为肺水肿、肺出血.研究重症EV71感染的临床特征和发病机制从而采取积极有效的措施阻断其并发症的发生具有重要意义.%Enterovirus 71(EV71),a member of human enterovirus family,was first isolated from faeces of a central nervous system infected infant in 1969.In recent 30 years,EV71 outbreaks every 2-3 years in the Asia-Pacific regions,and is the main pathogen causing severe hand-foot-mouth disease(HFMD).Severe HFMD caused by EV71 involves in central nervous system and respiratory system disorder.In general,EV71 associated complication is related to the viral invasion of central nervous system,leads to pulmonary edema or pulmonary hemorrhage.It is of great significance to study the clinical features and pathogenesis of EV71 infection,and then take positive and effective measures to block the occurrence of its complications.

  4. EV71感染的手足口病患儿体液免疫临床分析%Clinical analysis on humoral immunity in children with hand-foot-mouth disease by EV71 infection

    Institute of Scientific and Technical Information of China (English)

    周海兰; 李华东

    2011-01-01

    Objective To discuss the function of humoralimmunity in children with hand-foot-mouth disease ( HFMD )caused by EV71 infection. Methods Levels of IgG, IgA, IgM and C3, C4 were detected, respectively, in 30 children with HFMD of EV71 positive, 30 children with EV71 negative and 20 normal cases of healthy children. T test was used to analyze the differences of IgG, IgA, IgM and C3,C4 with levels among the EV71 positive group, EV71 negative group and control group by SPSS 18.0. Results There were no significant differences on serum levels of IgM,IgG, IgA, C3 and C4 between HFMD children with EV71 positive and EV71 negative. Serum levels of IgG, IgA, C3 and C4 were significantly reduced compared with those of normal controls ( P < 0.05 ), but serum level of IgM was significantly increased ( P < 0. 001 ). Conclusions The humoralimmunity function of children disordered after EV71 infection. But the influence to humoral immune function has no significant specificity.%目的 探讨并分析EV71感染手足病患儿体液免疫状况.方法 分别测定30例EV71阳性和30例EV71阴性的手足口病患儿与同期20例健康儿童的血清IgG、IgA、IgM及补体C3、C4水平,采用SPSS 18.0软件用t检验统计分析EV71阳性组的IgG、IgA、IgM及补体C3、C4水平与EV71阴性组和对照组各项指标水平的差异.结果 EV71阳性组和阴性组手足口病患儿各指标水平无显著差异;与对照组相比,EV71阳性组患儿血清IgG、IgA、C3、C4水平降低(P< 0.05);IgM明显升高(P< 0.001).结论 EV71感染的手足口病患儿存在体液免疫功能紊乱,但EV71感染对体液免疫功能影响无显著特异性.

  5. InterEvDock: a docking server to predict the structure of protein-protein interactions using evolutionary information.

    Science.gov (United States)

    Yu, Jinchao; Vavrusa, Marek; Andreani, Jessica; Rey, Julien; Tufféry, Pierre; Guerois, Raphaël

    2016-07-01

    The structural modeling of protein-protein interactions is key in understanding how cell machineries cross-talk with each other. Molecular docking simulations provide efficient means to explore how two unbound protein structures interact. InterEvDock is a server for protein docking based on a free rigid-body docking strategy. A systematic rigid-body docking search is performed using the FRODOCK program and the resulting models are re-scored with InterEvScore and SOAP-PP statistical potentials. The InterEvScore potential was specifically designed to integrate co-evolutionary information in the docking process. InterEvDock server is thus particularly well suited in case homologous sequences are available for both binding partners. The server returns 10 structures of the most likely consensus models together with 10 predicted residues most likely involved in the interface. In 91% of all complexes tested in the benchmark, at least one residue out of the 10 predicted is involved in the interface, providing useful guidelines for mutagenesis. InterEvDock is able to identify a correct model among the top10 models for 49% of the rigid-body cases with evolutionary information, making it a unique and efficient tool to explore structural interactomes under an evolutionary perspective. The InterEvDock web interface is available at http://bioserv.rpbs.univ-paris-diderot.fr/services/InterEvDock/.

  6. Radar Observations and the Shape of 2008 EV5: Ridges and Craters on Near-Earth Asteroids

    Science.gov (United States)

    Busch, Michael W.; Ostro, S. J.; Benner, L. A. M.; Scheeres, D. J.; Giorgini, J. D.; Brozovic, M.; Nolan, M. C.; Howell, E. S.; Taylor, P. A.; Margot, J.; Magri, C.; Jao, J. S.; Brisken, W.

    2010-10-01

    The near-Earth asteroid 2008 EV5 was discovered by the Mt. Lemmon Survey on March 4 2008, and approached to within 8.4 lunar distances in December 2008, when it was a very strong radar target. We observed EV5 with the Arecibo and Goldstone planetary radars and the Very Long Baseline Array, and previously described those observations and obtaining EV5's pole direction. We have now completed a detailed model of EV5's shape. The Arecibo delay-Doppler data provided 7.5-m spatial resolution, showing that EV5's overall shape is a 400 ± 50 m spheroid. The most prominent surface feature is a ridge parallel to the asteroid's equator that is broken by a concavity 150 m in diameter. Otherwise the asteroid's surface is shows few decameter-scale features and is notably smooth - our shape model has an average surface slope of <15º. EV5's radar and optical albedos are consistent with either rocky or stony-iron composition. EV5's ridge is similar to structure seen on the rubble-pile near-Earth asteroid (66391) 1999 KW4, and is consistent with YORP spin-up reconfiguring the asteroid during an episode of more rapid rotation. We interpret the concavity as an impact crater. Shaking during the impact should have erased smaller surface features and may explain the general lack of decameter-scale surface structure.

  7. Progress in research of enterovirus 71 vaccines%EV71疫苗研制新进展

    Institute of Scientific and Technical Information of China (English)

    赵蕾; 陈敬贤; 王明丽

    2013-01-01

    肠道病毒71型(enterovirus 71,EV71)是引起手足口病和神经系统并发症的重要病原体.近几年,世界多个地区发生了由EV72感染引起的手足口病.由于目前尚无有效的抗病毒药物对患者进行治疗,因而疫苗的研制成为预防和控制EV71传播的关键.此文主要就近年EV71疫苗的研制进展做一综述.%Enterovirus 71 (EV71) is known to be a causative agent of hand,foot and mouth disease (HFMD) and severe neurological complications.Many outbreaks caused by EV71 have occurred in different regions of the world.Due to lacking an effective antiviral agent,development of effective vaccines has become the top priority in terms of control strategies.This article reviews the recent advancement in the design of various kinds of vaccines against EV71.

  8. EV71 infection correlates with viral IgG preexisting at pharyngo-laryngeal mucosa in children.

    Science.gov (United States)

    Xue, Jingchang; Li, Yaoming; Xu, Xiaoyi; Yu, Jie; Yan, Hu; Yan, Huimin

    2015-04-01

    Enterovirus 71 (EV71) infection causes severe central nervous system damage, particularly for children under the age of 5 years old, which remains a major public health burden worldwide. Clinical data released that children may be repeatedly infected by different members in enterovirus and get even worsen. Mucosa, especially epithelium of alimentary canal, was considered the primary site of EV71 infection. It has been elusive whether the preexsiting viral antibody in mucosa plays a role in EV71 infection. To answer this question, we respectively measured viral antibody response and EV71 RNA copy number of one hundred throat swab specimens from clinically confirmed EV71-infected children. The results released that low-level of mucosal IgG antibody against EV71 broadly existed in young population. More importantly, it further elucidated that the children with mucosal preexsiting EV71 IgG were prone to be infected, which suggested a former viral IgG mediated enhancement of viral infection in vivo.

  9. Recombinant VP1 protein expressed in Pichia pastoris induces protective immune responses against EV71 in mice.

    Science.gov (United States)

    Wang, Man; Jiang, Shuai; Wang, Yefu

    2013-01-01

    Human enterovirus 71 (EV71) is one of the major causative agents of hand, foot and mouth disease and is also associated with serious neurological diseases in children. Currently, there are no effective antiviral drugs or vaccines against EV71 infection. VP1, one of the major immunogenic capsid proteins of EV71, is widely considered to be the candidate antigen for an EV71 vaccine. In this study, VP1 of EV71 was expressed as a secretory protein with an N-terminal histidine tag in the methylotrophic yeast Pichia pastoris, and purified by Ni-NTA affinity chromatography. Immunogenicity and vaccine efficacy of the recombinant VP1 were assessed in mouse models. The results showed that the recombinant VP1 could efficiently induce anti-VP1 antibodies in BALB/c mice, which were able to neutralize EV71 viruses in an in vitro neutralization assay. Passive protection of neonatal mice further confirmed the prophylactic efficacy of the antisera from VP1 vaccinated mice. Furthermore, VP1 vaccination induced strong lymphoproliferative and Th1 cytokine responses. Taken together, our study demonstrated that the yeast-expressed VP1 protein retained good immunogenicity and was a potent EV71 vaccine candidate.

  10. Laser Range Sensors

    Directory of Open Access Journals (Sweden)

    K.C. Bahuguna

    2007-11-01

    Full Text Available This paper presents the design aspects of laser range finders and proximity sensors being developed at IRDE for different applications. The principle used in most of the laser range finders is pulse echo or time-of-flight measurement. Optical triangulation is used in proximity sensors while techniques like phase detection and interferometry are employed in instruments for surveying and motion controllers where high accuracy is desired. Most of the laser range finders are designed for ranging non-cooperative targets.

  11. Conceptual Design of a Cosmic Ray Detector Operating Between 10^17 and 10^19 eV for the Study of the Galactic Center

    CERN Document Server

    Adams, T; Ben-Zvi, S Y; Westerhoff, S; Adams, Todd; Loh, Eugene C.; Zvi, Segev Ben; Westerhoff, Stefan

    2003-01-01

    For our understanding of the origin of ultra high energy cosmic rays, the energy region between 10^17 and 10^19 eV is of crucial importance. Previous experiments have found indirect evidence that at these energies, the origin of cosmic rays changes from predominantly Galactic to extragalactic. In addition, weak evidence for an excess of cosmic rays from the direction of the Galactic center in a narrow energy band around 10^18 eV has been claimed. However, so far there is no direct evidence supporting this scenario. Neither Galactic nor extragalactic sources have been unambiguously established. Given the importance of this energy range, there is a strong case for a dedicated experiment to study the EeV energy region with high precision. We present the conceptual design of GRaNDScan, a mobile stereo air fluorescence detector optimized to study the spectrum, composition, and arrival direction of cosmic rays in this important energy range. If located at a site on the southern hemisphere with good exposure to the ...

  12. Measurement of the neutron capture cross section of the s-only isotope 204Pb from 1 eV to 440 keV

    CERN Document Server

    Domingo-Pardo, C; Aerts, G; Alvarez-Pol, H; Alvarez-Velarde, F; Andriamonje, S; Andrzejewski, J; Assimakopoulos, P; Audouin, L; Badurek, G; Baumann, P; Becvar, F; Berthoumieux, E; Bisterzo, S; Calvino, F; Cano-Ott, D; Capote, R; Carrapico, C; Cennini, P; Chepel, V; Chiaveri, E; Colonna, N; Cortes, G; Couture, A; Cox, J; Dahlfors, M; David, S; Dillmann, I; Dolfini, R; Dridi, W; Duran, I; Eleftheriadis, C; Embid-Segura, M; Ferrant, L; Ferrari, A; Ferreira-Marques, R; Fitzpatrick, L; Frais-Koelbl, H; Fujii, K; Furman, W; Gallino, R; Goncalves, I; Gonzalez-Romero, E; Goverdovski, A; Gramegna, F; Griesmayer, E; Guerrero, C; Gunsing, F; Haas, B; Haight, R; Heil, M; Herrera-Martinez, A; Igashira, M; Isaev, S; Jericha, E; Kadi, Y; Kappeler, F; Karamanis, D; Karadimos, D; Kerveno, M; Ketlerov, V; Koehler, P; Konovalov, V; Kossionides, E; Krticka, M; Lamboudis, C; Leeb, H; Lindote, A; Lopes, I; Lozano, M; Lukic, S; Marganiec, J; Marrone, S; Mastinu, P; Mengoni, A; Milazzo, P.M; Moreau, C; Mosconi, M; Neves, F; Oberhummer, H; Oshima, M; O'Brien, S; Pancin, J; Papachristodoulou, C; Papadopoulos, C; Paradela, C; Patronis, N; Pavlik, A; Pavlopoulos, P; Perrot, L; Plag, R; Plompen, A; Plukis, A; Poch, A; Pretel, C; Quesada, J; Rauscher, T; Reifarth, R; Rosetti, M; Rubbia, C; Rudolf, G; Rullhusen, P; Salgado, J; Sarchiapone, L; Savvidis, I; Stephan, C; Tagliente, G; Tain, J.L; Tassan-Got, L; Tavora, L; Terlizzi, R; Vannini, G; Vaz, P; Ventura, A; Villamarin, D; Vincente, M.C; Vlachoudis, V; Vlastou, R; Voss, F; Walter, S; Wendler, H; Wiescher, M; Wisshak, K

    2007-01-01

    The neutron capture cross section of 204Pb has been measured at the CERN n_TOF installation with high resolution in the energy range from 1 eV to 440 keV. An R-matrix analysis of the resolved resonance region, between 1 eV and 100 keV, was carried out using the SAMMY code. In the interval between 100 keV and 440 keV we report the average capture cross section. The background in the entire neutron energy range could be reliably determined from the measurement of a 208Pb sample. Other systematic effects in this measurement could be investigated and precisely corrected by means of detailed Monte Carlo simulations. We obtain a Maxwellian average capture cross section for 204Pb at kT=30 keV of 79(3) mb, in agreement with previous experiments. However our cross section at kT=5 keV is about 35% larger than the values reported so far. The implications of the new cross section for the s-process abundance contributions in the Pb/Bi region are discussed.

  13. Air Shower Radio Emission with Energy E$_0$$\\geq$10$^{19}$ eV by Yakutsk Array Data

    CERN Document Server

    Knurenko, S P

    2016-01-01

    The paper presents short technical description of Yakutsk Radio Array and some preliminary results obtained from measurements of radio emission at 32 MHz frequency induced by air shower particles with energy {\\epsilon}$\\geq$1$\\cdot$10$^{19}$ eV. The data obtained at Yakutsk array in 1987-1989 (first set of measurements) and 2009-2014 (new set of measurements). For the first time, at Yakutsk array radio emission from air shower with energy > 10$^{19}$ eV was registered including the shower with highest energy ever registered at Yakutsk array with energy $\\sim$2$\\cdot$10$^{20}$ eV.

  14. Observation of the suppression of the flux of cosmic rays above 4x10^19eV

    CERN Document Server

    Abraham, J; Aglietta, M; Aguirre, C; Allard, D; Allekotte, I; Allen, J; Allison, P; Alvarez-Muñiz, J; Ambrosio, M; Anchordoqui, L; Andringa, S; Anzalone, A; Aramo, C; Argiro, S; Arisaka, K; Armengaud, E; Arneodo, `F; Arqueros, F; Asch, T; Asorey, H; Assis, P; Atulugama, B S; Aublin, J; Ave, M; Avila, G; Backer, T; Badagnani, D; Barbosa-Ademarlaudo, F; Barnhill, D; Barroso, S L C; Baughman, B; Bauleo, P; Beatty, J J; Beau, T; Becker, B R; Becker, K H; Bellido, J A; Ben Zvi, S; Bérat, C; Bergmann, T; Bernardini, P; Bertou, X; Biermann, P L; Billoir, P; Blanch-Bigas, O; Blanco, F; Blasi, P; Bleve, C; Blümer, H; Bohacova, M; Bonifazi, C; Bonino, R; Brack, J; Brogueira, P; Brown, W C; Buchholz, P; Bueno, A; Burton, R E; Busca, N G; Caballero-Mora, K S; Cai, B; Camin, D V; Caramete, L; Caruso, R; Carvalho, W; Castellina, A; Catalano, O; Cataldi, G; Cazon, L; Cester, R; Chauvin, J; Chiavassa, A; Chinellato, J A; Chou, A; Chudoba, J; Chye, J; Clark, P D J; Clay, R W; Colombo, E; Conceicao, R; Connolly, B; Contreras, F; Coppens, J; Cordier, A; Cotti, U; Coutu, S; Covault, C E; Creusot, A; Criss, A; Cronin, J; Curutiu, A; Dagoret-Campagne, S; Daumiller, K; Dawson, B R; de Almeida, R M; De Donato, C; De Jong, S J; De La Vega, G; de Mello Junior, W J M; De Mello-Neto, J R T; De Mitri, I; De Souza, V; Del Peral, L; Deligny, O; Della Selva, A; Delle Fratte, C; Dembinski, H; Di Giulio, C; Diaz, J C; Diep, P N; Dobrigkeit, C; D'Olivo, J C; Dong, P N; Dornic, D; Dorofeev, A; dos Anjos, J C; Dova, M T; D'Urso, D; Dutan, I; Duvernois, M A; Engel, R; Epele, L; Erdmann, M; Escobar, C O; Etchegoyen, A; Facal San Luis, P; Falcke, H; Farrar, G; Fauth, A C; Fazzini, N; Ferrer, F; Ferrero, A; Fick, B; Filevich, A; Filipcic, A; Fleck, I; Fracchiolla, C E; Fulgione, W; Garca, B; Garca Gamez, D; Garcia-Pinto, D; Garrido, X; Geenen, H; Gelmini, G; Gemmeke, H; Ghia, P L; Giller, M; Glass, i H; Gold, M S; Golup, G; Gomez Albarracin, F; Gomez Berisso, M; Gonçalves, P; Goncalvesdo Amaral, M; González, D; Gonzalez, J G; González, M; Gora, D; Gorgi, A; Gouffon, P; Grassi, V; Grillo, A F; Grunfeld, C; Guardincerri, Y; Guarino, F; Guedes, G P; Gutíerrez, J; Hague, J D; Halenka, V; Hamilton, J C; Hansen, P; Harari, D; Harmsma, S; Harton, J L; Haungs, A; Hauschildt, T; Healy, M D; Hebbeker, T; Hebrero, G; Heck, D; Hojvat, C; Holmes, V C; Homola, P; Hörandel, J R; Horneffer, A; Hrabovsky, M; Huege, T; Hussain, M; Iarlori, M; Insolia, A; Ionita, F; Italiano, A; Kaducak, M; Kampert, K H; Karova, T; Kasper, P; Kegl, B; Keilhauer, B; Kemp, E; Kieckhafer, R M; Klages, H O; Kleifges, M; Kleinfeller, J; Knapik, R; Knapp, J; Koang, D H; Krieger, A; Krömer, O; Kuempel, D; Kunka, N; Kusenko, A; La Rosa, G; Lachaud, C; Lago, B L; Lebrun, D; Lebrun, P; Lee, J; Leiguide Oliveira, M A; Letessier-Selvon, A A; Leuthold, M; Lhenry-Yvon, I; López, R; López-Aguera, A; Lozano-Bahilo, J; Lucero, A; Luna Garca, R; Maccarone, i M C; Macolino, C; Maldera, S; Mancarella, G; Mancenido, M E; Mandat, D; Mantsch, P; Mariazzi, A G; Maris, I C; Marquez Falcon, H R; Martello, D; Martínez, J; Martinez Bravo, O; Mathes, H J; Matthews, J; Matthews, J A J; Matthiae, Giorgio; Maurizio, D; Mazur, P O; McCauley, T; McEwen, M; McNeil, R R; Medina, M C; Medina-Tanco, G; Melo, D; Menichetti, E; Menschikov, A; Meurer, C; Meyhandan, R; Micheletti, M I; Miele, G; Miller, W; Mollerach, S; Monasor, M; Monnier Ragaigne, D; Montanet, F; Morales, B; Morello, C; Moreno, J C; Morris, C; Mostafa, M; Muller, M A; Mussa, R; Navarra, G; Navarro, J L; Navas, S; Necesal, P; Nellen, L; Newman-Holmes, C; Newton, D; Nhung, P T; Nierstenhoefer, N; Nitz, D; Nosek, D; Nozka, L; Oehlschläger, J; Ohnuki, T; Olinto, A; Olmos-Gilbaja, V M; Ortiz, M; Ortolani, F; Ostapchenko, S; Otero, L; Pacheco, N; Pakk Selmi-Dei, D; Palatka, M; Pallotta, J; Parente, G; Parizot, E; Parlati, S; Pastor, S; Patel, M; Paul, T; Pavlidou, V; Payet, K; Pech, M; Pekala, J; Pelayo, R; Pepe, I M; Perrone, L; Pesce, R; Petrera, S; Petrinca, P; Petrov, Y; Pichel, A; Piegaia, R; Pierog, T; Pimenta, M; Pinto, T; Pirronello, V; Pisanti, O; Platino, M; Pochon, J; Privitera, P; Prouza, M; Quel, E J; Rautenberg, J; Redondo, A; Reucroft, S; Revenu, B; Rezende, F A S; Rídky, J; Riggi, S; Risse, M; Rivière, C; Rizi, V; Roberts, M; Robledo, C; Rodríguez, G; Rodríguez-Martino, J; Rodriguez Rojo, J; Rodriguez-Cabo, I; Rodrguez-Fras, M D; Ros, G; Rosado, J; Roth, M; Rouille-d'Orfeuil, B; Roulet, E; Rovero, A C; Salamida, F; Salazar, ii H; Salina, G; Sánchez, F; Santander, M; Santo, C E; Santos, E M; Sarazin, F; Sarkar, S; Sato, R; Scherini, V; Schieler, H; Schmidt, A; Schmidt, F; Schmidt, T; Scholten, O; Schovanek, P; Schroeder, F; Schulte, S; Schussler, F; Sciutto, S J; Scuderi, M; Segreto, A; Semikoz, D; Settimo, M; Shellard, R C; Sidelnik, I; Siffert, B B; Sigl, G; Smetniansky De Grande, N; Smialkowski, A; Smda, R; Smith, A G K; Smith, B E; Snow, G R; Sokolsky, P; Sommers, P; Sorokin, J; Spinka, H; Squartini, R; Strazzeri, E; Stutz, A; Suárez, F; Suomijärvi, T; Supanitsky, A D; Sutherland, M S; Swain, J; Szadkowski, Z; Takahashi, J; Tamashiro, A; Tamburro, A; Tarutina, T; Tascau, O; Tcaciuc, R; Thao, N T; Thomas, D; Ticona, R; Tiffenberg, J; Timmermans, C; Tkaczyk, W; Todero Peixoto, C J; Tomé, B; Tonachini, A; Torres, I; Travnicek, P; Tripathi, A; Tristram, G; Tscherniakhovski, D; Tuci, V; Tueros, M; Tunnicliffe, V; Ulrich, R; Unger, M; Urban, M; Valdés-Galicia, J F; Valino, I; Valore, L; vanden Berg, A M; van Elewyck, V; Vázquez, R A; Veberic, D; Veiga, A; Velarde, A; Venters, T; Verzi, V; Videla, M; Villaseñor, L; Vorobiov, S; Voyvodic, L; Wahlberg, H; Wahrlich, P; Wainberg, O; Walker, P; Warner, D; Watson, A A; Westerhoff, S; Wieczorek, G; Wiencke, L; Wilczynska, B; Wilczynski, H; Wileman, C; Winnick, M G; Wu, H; Wundheiler, B; Yamamoto, T; Younk, P; Zas, E; Zavrtanik, D; Zavrtanik, M; Zaw, I; Zepeda, A; Ziolkowski, M

    2008-01-01

    The energy spectrum of cosmic rays above 2.5x10^18eV, derived from 20,000 events recorded at the Pierre Auger Observatory, is described. The spectral index gamma of the flux, J ~ E^-gamma, at energies between 4x10^18eV and 4x10^19eV is 2.69+-0.02(stat)+-0.06(syst), steepening to 4.2+-0.4(stat)+-0.06(syst) at higher energies, consistent with the prediction by Greisen and by Zatsepin and Kuz'min.

  15. On Range of Skill

    DEFF Research Database (Denmark)

    Hansen, Thomas Dueholm; Miltersen, Peter Bro; Sørensen, Troels Bjerre

    2008-01-01

    size (and doubly exponential in its depth). We also provide techniques that yield concrete bounds for unbalanced game trees and apply these to estimate the Range of Skill of Tic-Tac-Toe and Heads-Up Limit Texas Hold'em Poker. In particular, we show that the Range of Skill of Tic-Tac-Toe is more than...

  16. Substring Range Reporting

    DEFF Research Database (Denmark)

    Bille, Philip; Gørtz, Inge Li

    2011-01-01

    to a new problem, which we call substring range reporting. Hence, we unify the previous work by showing that we may restrict our attention to a single problem rather than studying each of the above problems individually. – We show how to solve substring range reporting with optimal query time and little...

  17. Range Scheduling Aid (RSA)

    Science.gov (United States)

    Logan, J. R.; Pulvermacher, M. K.

    1991-01-01

    Range Scheduling Aid (RSA) is presented in the form of the viewgraphs. The following subject areas are covered: satellite control network; current and new approaches to range scheduling; MITRE tasking; RSA features; RSA display; constraint based analytic capability; RSA architecture; and RSA benefits.

  18. Antigenic analysis of divergent genotypes human Enterovirus 71 viruses by a panel of neutralizing monoclonal antibodies: current genotyping of EV71 does not reflect their antigenicity.

    Science.gov (United States)

    Chen, Yixin; Li, Chuan; He, Delei; Cheng, Tong; Ge, Shengxiang; Shih, James Wai-Kuo; Zhao, Qinjian; Chen, Pei-Jer; Zhang, Jun; Xia, Ningshao

    2013-01-01

    In recent year, Enterovirus 71 (EV71)-associated hand, foot and mouth disease (HFMD) has become an important public health issue in China. EV71 has been classified into genotypes A, B1-B5 and C1-C5. With such genetic diversity, whether the convalescent or recovery antibody responses can cross-protect infections from other genotypes remains a question. Understanding of the antigenicity of such diverse genetic EV71 isolates is crucial for the EV71 vaccine development. Here, a total of 186 clones anti-EV71 MAbs was generated and characterized with Western blot and cell-based neutralization assay. Forty neutralizing anti-EV71 MAbs were further used to analyze the antigenic properties of 18 recent EV71 isolates representing seven genotypes in neutralization assay. We found that most neutralizing anti-EV71 MAbs are specific to conformational epitopes. We also classified the 40 neutralizing anti-EV71 MAbs into two classes according to their reactivity patterns with 18 EV71 isolates. Class I MAb can neutralize all isolates, suggesting conserved epitopes are present among EV71. Class II MAb includes four subclasses (IIa-IId) and neutralizes only subgroups of EV71 strains. Conversely, 18 EV71 strains were grouped into antigenic types 1 and four antigenic subtypes (2.1-2.4). These results suggest that the current genotyping of EV71 does not reflect their antigenicity which may be important in the selection of EV71 vaccine strains. This panel of neutralizing anti-EV71 MAbs may be useful for the recognition of emerging antigenic variants of EV71 and vaccine development.

  19. Home range and travels

    Science.gov (United States)

    Stickel, L.F.; King, John A.

    1968-01-01

    The concept of home range was expressed by Seton (1909) in the term 'home region,' which Burr (1940, 1943) clarified with a definition of home range and exemplified in a definitive study of Peromyscus in the field. Burt pointed out the ever-changing characteristics of home-range area and the consequent absence of boundaries in the usual sense--a finding verified by investigators thereafter. In the studies summarized in this paper, sizes of home ranges of Peromyscus varied within two magnitudes, approximately from 0.1 acre to ten acres, in 34 studies conducted in a variety of habitats from the seaside dunes of Florida to the Alaskan forests. Variation in sizes of home ranges was correlated with both environmental and physiological factors; with habitat it was conspicuous, both in the same and different regions. Food supply also was related to size of home range, both seasonally and in relation to habitat. Home ranges generally were smallest in winter and largest in spring, at the onset of the breeding season. Activity and size also were affected by changes in weather. Activity was least when temperatures were low and nights were bright. Effects of rainfall were variable. Sizes varied according to sex and age; young mice remained in the parents' range until they approached maturity, when they began to travel more widely. Adult males commonly had larger home ranges than females, although there were a number of exceptions. An inverse relationship between population density and size of home range was shown in several studies and probably is the usual relationship. A basic need for activity and exploration also appeared to influence size of home range. Behavior within the home range was discussed in terms of travel patterns, travels in relation to home sites and refuges, territory, and stability of size of home range. Travels within the home range consisted of repeated use of well-worn trails to sites of food, shelter, and refuge, plus more random exploratory travels

  20. EV71病毒感染并发神经源性肺水肿研究进展%Progression on the study of EV71 complicating meurogenic pulmonary edema

    Institute of Scientific and Technical Information of China (English)

    李文先; 叶冬青

    2008-01-01

    2008年春季,EV71病毒感染疫情在安徽省阜阳市暴发,由其引起的手足口病(hand—foot—mouth disease,HFMD)于5月2日被卫生部纳入法定报告传染病。截至5月5日,安徽省阜阳市共发生婴幼儿因肠道病毒EV71(enterovirus71,EV71)引起的HFMD4496例,其中22例死亡。EV71病毒感染已经成为我国重要的公共卫生问题。

  1. 肠道病毒EV71型对不同细胞的敏感性研究%Study on the sensitivity of intestinal virus EV71 in different cells

    Institute of Scientific and Technical Information of China (English)

    李冰洁

    2015-01-01

    目的 确定肠道病毒EV71的敏感细胞.方法 采用三种不同细胞(HEP-2、VERO、RD)对EV71核酸检测阳性标本进行病毒分离,对比不同细胞的分离率来比较细胞的敏感性.结果 本研究中肠道病毒EV71型对VERO细胞的敏感性最高,其次是RD细胞,对HEP-2细胞不敏感.结论 分离肠道病毒EV71型首选的细胞是VERO细胞.

  2. DYNAMICS OF THE REACTION OF N{sup +} WITH H{sub 2}. V. REACTIVE AND NON-REACTIVE SCATTERING OF N{sup +}({sup 3}p) AT RELATIVE ENERGIES BELOW 3.6 eV.

    Energy Technology Data Exchange (ETDEWEB)

    Hansen, Steven G.; Farrar, James M.; Mahan, Bruce H.

    1980-05-01

    We have measured product velocity vector distributions for the processes N{sup +}({sup 3}P)(H{sub 2},H)NH{sup +} and N{sup +}({sup 3}P)(H{sub 2},H{sub 2})N+ in the initial relative energy ranges of 0.98~3.60 eV and 0.66~ 2.50 eV respectively using the crossed beam technique. At energies below about 1.9 eV the predominance of a long-lived NH{sub 2}{sup +} complex is inferred from isotropic reactive scattering and a backscattered peak in the non-reactive distributions. Above 1.9 eV there is still a substantial interaction between all three atoms. The dynamics are adequately explained by a mechanism which involves accessing the deep {sup 3}B{sub 1} potential well through an avoided crossing with the {sup 3}A{sub 2} surface when the ·symmetry is relaxed from C{sub 2v} to C{sub s}. The reaction of electronically excited metastable ions, probably N{sup +}({sup 1}D), is seen as a forward peak in the reactive distributions.

  3. 2010年中国人免疫球蛋白中EV71中和抗体效价的比较研究%Study of anti- EV71 neutralizing titers of human immunoglobulins made in China in 2010

    Institute of Scientific and Technical Information of China (English)

    毛群颖; 郭增兵; 李青; 梁争论; 李凤祥; 王军志

    2011-01-01

    Objective: To explore the anti - EV71 titer in human immunoglobulins produced by different blood product manufacturers in China in 2010. To provide specific drugs for hand,foot and mouth disease( HFMD) caused by EV71. Methods: 97 Lots of human immunoglobulins for intravenous injection (IVIG) produced by different manufacturers were tested for neutralizing antibodies (NTAb) to EV71 by microneutralization test with 2 different EV71 viruses, which isolated from mainland china in the past two years. The difference of anti - EV71 titer in IVIG has been compared. Results:The geometric mean titers (GMTs) of EV71 NTAb in 97 Lots IVIG is 1: 180 (1= 170 -1:191). The titers of EV71 NTAb in 12 Lots IVIG produced by 7 different manufacturers have been more than 1 ':256,and the IVIG of Lot 20100406 produced by S manufacturer has the highest titer (1:543). The A manufacturer had made the most Lot of IVIG (5 batches) with anti -EV71 titer higher than 1:512,that made the average of anti -EV71 from A manufacturer to be obviously higher than other 10 manufacturers (P <0. 05). Further analysis revealed that S manufacturer had tested the anti - EV71 titers in plasma of raw materials and selected the plasma with high titer of EV71 to produce this Lot IVIG; and A manufacturer selected the areas with high anti - EV71 levels in populations as a plasma source to feed and make IVIGs. Conclusion: This study shows that through controlling the neutralizing antibodies levels to EV71 of raw materials efficiently by the manufacturer, it is scientific and feasible to produce IVIG with high anti -EV71 titer.%目的:了解2010年我国生产的静注人免疫球蛋白(IVIG)中抗- EV71中和抗体效价的情况,为治疗EV71引起的手足口病( HFMD)提供特异性治疗药物.方法:采用经典微量细胞病变法,应用近2年分离自中国大陆的2株肠道病毒71型(EV71)病毒株,对我国不同血液制品厂家生产的97批IVIG进行抗- EV71中和效价检测,比较不同批次IVIG的EV

  4. The role of toll-like receptors in the pathogenesis of EV71 infection%Toll样受体在EV71感染发病机制中的作用

    Institute of Scientific and Technical Information of China (English)

    马慧敏; 欧维琳

    2014-01-01

    肠道病毒71型(EV71)易致婴幼儿重症手足口病(HFMD),是近年来儿童发病率最高的传染病,严重的脑干脑炎和神经源性肺水肿是其致死的主要原因.目前EV71精确发病机制尚未阐明,在细胞水平研究发现清道夫受体B族2型(SCARB2)既是EV71病毒受体,也是Toll样受体(TLRs)内源性配体.TLRs作为重要的病原模式识别受体能够识别EV71,与宿主抵抗病毒感染、炎症反应等有直接关系,可能参与介导EV71感染所致混合性拮抗反应综合征(MARS).现就Toll样受体在EV71感染发病机制中的作用研究现状进行概述.

  5. EV71特免血浆筛选方法的建立及其应用%Establishment and application of method to screen anti-EV71 positive plasma

    Institute of Scientific and Technical Information of China (English)

    郭书英; 汪模正; 丁勇; 孙思才

    2013-01-01

    Objective To evaluate the titers of EV71 neutralizing antibody in donators' plasma,and to establish a high throughput screening method to screening anti-EV71 positive plasma for the production of EV7l-specific IVIG in practice.Methods The EV71 neutralizing antibody titers in plasma samples and in commercial IVIGs (intravenous immunoglobulins) were evaluated by micro-cytopathic effect neutralization test (MCPENT),and a selecting criteria was determined for screening anti-EV71 positive plasma.Then,a high throughput neutralizing method for screening plasma was established and a comparison with MCPENT was conducted.EV71-specific IVIG was prepared from screened anti-EV71 source plasma,and its neutralizing activity was evaluated in cell model and mouse model.Results The results of MCPENT showed that the titers of EVT1 neutralizing antibody were 1 ∶ 50 or above in 20% of the source plasma,and reached 1 ∶ 180 after being pooled,approaching to the titer of commercial IVIG.In 480 samples,the coincidence rate between the established high throughput neutralizing method and MCPENT was 88.1%.The quality of prepared EV71-specific IVIG was complied with the national standard,and its neutralizing potency was 16 times of that of IVIG,suggesting EV71-specific IVIG had a significantly improved protecting effect on experimental neonatal mice.Conclusion The screening method and the screening criteria for EV71 specific plasma were successfully established.The established high throughput neutralizing method that was operated easily could be used for plasma screening in the development of EV71-specific IVIG.The prepared EV71-specific IVIG,whose neutralizing potency was significantly improved,showed a markedly protective effect on experimental neonatal mice,suggesting it might be very important for the prevention and treatment of handfoot-and-mouth disease.%目的 考察献血员血浆中抗EV71中和抗体的状况,同时建立适宜的高通量筛选EV71特免血浆的方法,为制备EV

  6. Femtosecond two-photon ionization of fluid NH3 at 9.3 eV

    Directory of Open Access Journals (Sweden)

    Torres-Alacan Joel

    2013-03-01

    Full Text Available Liquid and supercritical ammonia (NH3 is photo-ionized at an energy of 9.3 eV with 100-fs duration pulses at a wavelength of 266 nm. The ionization involves two photons and generates fully solvated electrons via the conduction band of the solvent within the time resolution of the experiment. The dynamics of their ensuing geminate recombination is followed in real time with femtosecond near-infrared (IR probe pulses. The recombination mechanism can be understood as an ion-pair mediated reaction. The electron survival probability is found to be in quantitative agreement with the classical Onsager theory for the initial recombination of ions.

  7. Pilot power based rate control in CDMA 2000 1x EV-DO Rev-A

    Institute of Scientific and Technical Information of China (English)

    LIU Xiao-feng; GU Jian; YANG Hong-wen

    2008-01-01

    This article proposes a new algorithm to improvethe rate control efficiency of enhanced reverse link mediumaccess control (RLMAC) in the code division multiple access(CDMA) lx EV-DO release A(Rev. A) system. The newalgorithm brings reverse access terminal (AT) pilot power tothe RLMAC rate control procedure and makes it easier for alow pilot power user to increase its data rate when the systemis slightly loaded and harder to decrease its date rate when thesystem is heavily loaded. Numerical results of system levelsimulations show that the new algorithm can bring highersystem throughput, lower AT transmission power, and lowersystem load.

  8. Der Landesjagdverband Sachsen-Anhalt e.V. stellt sich vor

    OpenAIRE

    Kramer, Dietrich

    2014-01-01

    Der Landesjagdverband Sachsen-Anhalt e.V. wurde am 20.04.1990 gegründet. Er vertritt die Interessen von 8.500 Mitgliedern und hat in seiner Satzung die Ziele seiner Verbandstätigkeit eindeutig definiert. Seine wesentliche Zielstellung ist der Schutz und die Erhaltung der freilebenden Tierwelt in ihren natürlichen Lebensräumen. Der Verband wirkt für die Erhaltung und Gestaltung der Lebensgrundlagen der freilebenden Tierwelt unter komplexer Beachtung ökologischer Erfordernisse und der Interesse...

  9. MoS2 interactions with 1.5 eV atomic oxygen

    Science.gov (United States)

    Martin, J. A.; Cross, J. B.; Pope, L. E.

    1989-01-01

    Exposures of MoS2 to 1.5-eV atomic oxygen in an anhydrous environment reveal that the degree of oxidation is essentially independent of crystallite orientation, and that the surface-adsorbed reaction products are MoO3 and MoO2. A mixture of oxides and sulfide exists over a depth of about 90 A, and this layer has a low diffusion rate for oxygen. It is concluded that a protective oxide layer forms on MoS2 on exposure to the atomic-oxygen-rich environment of LEO.

  10. Interpretation of fluctuations of shower front structure Esub(p) approximately 1018 eV

    International Nuclear Information System (INIS)

    The predictions of a conventional multiplicity EAS model (Hillas E) at 1018 eV are not consistent with pulse profile measurements and their observed fluctuations even when 100% primary proton composition is assumed. For α-primaries the discrepancy is more severe and for both proton primaries and for α-primaries cannot be resolved by changes in the interaction length of nucleons. Models developing more rapid initial growth seem likely to fit the measured parameters more successfully, but it is not yet possible to indicate how strongly proton and heavy primaries will be differentiated. (orig.)

  11. INDIGO OTROCI - VZGOJA GENERACIJE INDIGO S STALIŠČA STARŠEV

    OpenAIRE

    Sovič, Maja

    2012-01-01

    V zadnjih desetletjih so se začele pojavljati nove generacije tako imenovanih »indigo otrok«, katerih fenomen je obkrožil svet. Kljub temu da je ta koncept zelo popularen, pa stroka tega fenomena še ni uspela znanstveno potrditi. Tako fenomen indigo otrok še vedno ostaja na poljudni ravni in empirično nedokazljiv. Namen moje diplomske naloge je bil osvetliti problematiko vzgoje otrok s stališča staršev, kateri tipi indigo otrok glede na mnenja strokovnjakov obstajajo in ali so indigo nadarjen...

  12. Search for eV (pseudo)scalar penetrating particles in the SPS neutrino beam

    OpenAIRE

    Astier, P.; Autiero, D.; Baldisseri, A.; Baldo-Ceolin, M.; Ballocchi, G.; Banner, M.; Bassompierre, G.; Benslama, K.; Besson, N.; Bird, I.; Blumenfeld, B.; Bobisut, F.; Bouchez, J.; Boyd, S; Bueno, A.

    2000-01-01

    We carried out a model-independent search for light scalar or pseudoscalar particles $a$'s (an example of which is the axion) that couple to two photons by using a photon-regeneration method at high energies allowing a substantial increase in the sensitivity to $eV$ masses.\\ The experimental set-up is based on elements of the CERN West Area Neutrino Facility (WANF) beam line and theNOMAD neutrino detector.\\ The new particles, if they exist, could be produced through the Primakoff effect in in...

  13. Search for eV (pseudo)scalar penetrating particles in the SPS neutrino beam

    OpenAIRE

    NOMAD Collaboration; Astier, P.; Cervera Villanueva, Anselmo; Gómez Cadenas, Juan José

    2000-01-01

    We carried out a model-independent search for light scalar or pseudoscalar particles a's (an example of which is the axion) that couple to two photons by using a photon-regeneration method at high energies allowing a substantial increase in the sensitivity to eV masses.\\ The experimental set-up is based on elements of the CERN West Area Neutrino Facility (WANF) beam line and theNOMAD neutrino detector.\\ The new particles, if they exist, could be produced through the Primakoff effect in intera...

  14. Range_Extent_15

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — The GIS layer "Range_extent_15" is a simple polyline representing the geographic distribution of the southern sea otter (Enhydra lutris nereis) in mainland...

  15. Atlantic Test Range (ATR)

    Data.gov (United States)

    Federal Laboratory Consortium — ATR controls fully-instrumented and integrated test ranges that provide full-service support for cradle-to-grave testing. Airspace and surface target areas are used...

  16. Correlation radio range finder

    Directory of Open Access Journals (Sweden)

    A. Sorochan

    2012-10-01

    Full Text Available In work widely known methods of range measuring are short characterized. The basic attention is given features of signal processing in a correlation method of range measuring. The signal with angular modulation with one-voice-frequency fluctuation is used as a probing signal. The absence of Doppler effect on the formation of the correlation integral, the frequency instability of the transmitter, the phase change on reflection from the target is presented. It is noticed that the result of signal processing in the range measuring instrument is reduced to formation on an exit one-voice-frequency harmonious fluctuation equal to modulating frequency that provides high characteristics of a radio range finder.

  17. Light Detection And Ranging

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — LiDAR (Light Detection and Ranging) discrete-return point cloud data are available in the American Society for Photogrammetry and Remote Sensing (ASPRS) LAS format....

  18. Trails, RS2477, 3200 ev, Published in 2005, 1:24000 (1in=2000ft) scale, Iron County.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Trails, RS2477 dataset, published at 1:24000 (1in=2000ft) scale, was produced all or in part from Other information as of 2005. It is described as '3200 ev'....

  19. Deriving the characteristics of warm electrons (100-500 eV) in the magnetosphere of Saturn with the Cassini Langmuir probe

    Science.gov (United States)

    Garnier, P.; Holmberg, M. K. G.; Wahlund, J.-E.; Lewis, G. R.; Schippers, P.; Coates, A.; Gurnett, D. A.; Waite, J. H.; Dandouras, I.

    2014-12-01

    Though Langmuir probes (LP) are designed to investigate cold plasma regions (e.g. ionospheres), a recent analysis revealed a strong sensitivity of the Cassini LP measurements to hundreds of eV electrons. These warm electrons impact the surface of the probe and generate a significant current of secondary electrons, that impacts both the DC level and the slope of the current-voltage curve of the LP (for negative potentials) through energetic contributions that may be modeled with a reasonable precision. We show here how to derive information about the incident warm electrons from the analysis of these energetic contributions, in the regions where the cold plasma component is small with an average temperature in the range ~ [ 100 - 500 ] eV. First, modeling the energetic contributions (based on the incident electron flux given by a single anode of the CAPS spectrometer) allows us to provide information about the pitch angle anisotropies of the incident hundreds of eV electrons. The modeling reveals indeed sometimes a large variability of the estimated maximum secondary electron yield (which is a constant for a surface material) needed to reproduce the observations. Such dispersions give evidence for strong pitch angle anisotropies of the incident electrons, and using a functional form of the pitch angle distribution even allows us to derive the real peak angle of the distribution. Second, rough estimates of the total electron temperature may be derived in the regions where the warm electrons are dominant and thus strongly influence the LP observations, i.e. when the average electron temperature is in the range ~ [ 100 - 500 ] eV. These regions may be identified from the LP observations through large positive values of the current-voltage slope at negative potentials. The estimated temperature may then be used to derive the electron density in the same region, with estimated densities between ~ 0.1 and a few particles /cm3 (cc). The derived densities are in better

  20. Smart Grid Charging of Electric Vehicles: EV-Owner Response to Scheduling and Pricing under Myopic Loss Aversion in an Ultimatum Two-Player Game

    OpenAIRE

    Fetene, Gebeyehu Manie; Kaplan, Sigal; Sebald, Alexander Christopher; Prato, Carlo Giacomo

    2015-01-01

    Upward expectations of future electric vehicle (EV) growth pose the question about the future load on the electricity grid. While the literature on demand side management of EV charging has focused on technical aspects and considered EV-owners as utility maximizers, this study looks at the neglected psychological dynamics of EV-owners facing charging decisions and interacting with the supplier. This study represents these dynamics by proposing a behavioral framework of utility maximization un...

  1. Different EV enrichment methods suitable for clinical settings yield different subpopulations of urinary extracellular vesicles from human samples

    OpenAIRE

    Royo, Felix; Zuñiga-Garcia, Patricia; Sanchez-Mosquera, Pilar; Egia, Ainara; Perez, Amparo; Loizaga, Ana; Arceo, Raquel; Lacasa, Isabel; Rabade, Ainara; Arrieta, Edurne; Bilbao, Roberto; Unda, Miguel; Carracedo, Arkaitz; Falcon-Perez, Juan M.

    2016-01-01

    Urine sample analysis is irreplaceable as a non-invasive method for disease diagnosis and follow-up. However, in urine samples, non-degraded protein and RNA may be only found in urinary extracellular vesicles (uEVs). In recent years, various methods of uEV enrichment using low volumes of urine and unsophisticated equipment have been developed, with variable success. We compared the results of the differential ultracentrifugation procedure with 4 of these methods. The methods tested were a lec...

  2. EV71疫苗研究进展%Progress of reaseach on vaccine of Enterovirus 71

    Institute of Scientific and Technical Information of China (English)

    刘刚; 姚昕; 李凤祥

    2009-01-01

    肠道病毒71型(EV71),可引起手足口病(HFMD)和严重神经系统疾病.近年来,在世界多个国家和地区报道了EV71的爆发.由于目前缺乏有效的抗病毒药物,因此研制有效的疫苗是控制EV71流行最为有效的策略.近年来很多报道显示在EV71疫苗研究上取得了重要进展,本文以此为重点概括了EV71灭活疫苗、重组疫苗、DNA疫苗、多肽疫苗、减毒活疫苗等以及动物模型方面的研究进展.%Enterovirus 71(EV71)is known to be a causative agent of hand-foot-mouth disease(HFMD)and severe neurological complications.Many Ev71 outbreaks have been reposed in different regions of the world.Due to the lack of an effective antiviralagent,primary prevention of the disease,including the development of effective vaccines,has been the top priority in terms of control strategies.Recently,many reports indicated lots of important progression is acquired.In this article,we renewed the progression of EV71 animal model and vaccines which inchded inactivation vaccine,recombinant vaccine,DNA vaccine,polypeptide vaccine and live attenuated vaccine.

  3. Recoil ion and electronic angular asymmetry parameters for photo double ionization of helium at 99 eV

    Energy Technology Data Exchange (ETDEWEB)

    Braeuning, H. [Kansas State Univ., Physics Dept., Manhattan, KS (United States)]|[Lawrence Berkeley National Lab., Berkeley, CA (United States); Doerner, R.; Braeuning-Demian, A. [Universitaet Frankfurt, Inst. fuer Kernphysik, Frankfurt (Germany)] [and others

    1997-10-14

    Recoil ion momentum spectroscopy has been used to map the entire five-dimensional momentum space of the photo double ionization of helium at 20 eV above threshold. Angular asymmetry parameters for the relative motion of the electrons and the recoil ion have been determined and are found to be close to similar data at 1 eV above threshold. In addition the asymmetry parameter of one photoelectron is found to be in good agreement with recent theory. (author).

  4. Neljapäev sobib töö tegemiseks kõige vähem / Tõnu Vare

    Index Scriptorium Estoniae

    Vare, Tõnu, 1947-

    2006-01-01

    Uuringufirma Robert Half Finance & Accounting läbiviidud 1800 haldus- ja personalitöötaja küsitlus 11 riigis näitas, et kõige sobivam päev töötegemiseks on esmaspäev, kõige kiiremini elavad pärast puhkust igapäevatöösse sisse itaallased ja kõige aeglasemalt luksemburglased

  5. Generic methodology for driving range estimation of electric vehicle with on-road charging

    NARCIS (Netherlands)

    Shekhar, A.; Prasanth, V.; Bauer, P.; Bolech, M.

    2015-01-01

    An analytical estimation of driving range of electric vehicles (EVs) with contactIess on-road charging system is presented in this paper. Inductive power transfer (IPT) systems with different configurations (static, dynamic), power levels and road coverage have different (and non-linear) impact on t

  6. Electric vehicle (EV) storage supply chain risk and the energy market: A micro and macroeconomic risk management approach

    Science.gov (United States)

    Aguilar, Susanna D.

    As a cost effective storage technology for renewable energy sources, Electric Vehicles can be integrated into energy grids. Integration must be optimized to ascertain that renewable energy is available through storage when demand exists so that cost of electricity is minimized. Optimization models can address economic risks associated with the EV supply chain- particularly the volatility in availability and cost of critical materials used in the manufacturing of EV motors and batteries. Supply chain risk can reflect itself in a shortage of storage, which can increase the price of electricity. We propose a micro-and macroeconomic framework for managing supply chain risk through utilization of a cost optimization model in combination with risk management strategies at the microeconomic and macroeconomic level. The study demonstrates how risk from the EVs vehicle critical material supply chain affects manufacturers, smart grid performance, and energy markets qualitatively and quantitatively. Our results illustrate how risk in the EV supply chain affects EV availability and the cost of ancillary services, and how EV critical material supply chain risk can be mitigated through managerial strategies and policy.

  7. A functional polymorphism in IFNAR1 gene is associated with susceptibility and severity of HFMD with EV71 infection.

    Science.gov (United States)

    Zou, Rongrong; Zhang, Guoliang; Li, Shaoyuan; Wang, Wenfei; Yuan, Jing; Li, Jianming; Wang, Yanrong; Lin, Yimin; Deng, Yong; Zhou, Boping; Gao, George Fu; Liu, Yingxia

    2015-01-01

    Enterovirus 71 (EV71), one of the major pathogens of Hand, foot and mouth disease (HFMD), results in millions of infections and hundreds of deaths each year in Southeast Asia. Biased infection and variable clinical manifestations of EV71 HFMD indicated that host genetic background played an important role in the occurrence and development of the disease. We identified the mRNA profiles of EV71 HFMD patients, which type I interferon (IFN) pathway related genes were down-regulated. Four single nucleotide polymorphisms (SNPs) of type I IFN receptor 1 (IFNAR1) were chosen to analyze their relationships to EV71 infection. We found that genotype GG of promoter variant rs2843710 was associated with the susceptibility and severity to EV71 HFMD. In addition, we assessed the regulatory effects of rs2843710 to IFN stimulated genes (ISGs), and found that the expressions of IFNAR1, OAS1 and MX1 were significantly lower in patients with rs2843710 genotype GG. And rs2843710 allele G showed weaker transcriptional activity compared with allele C. Our study indicated that rs2843710 of IFNAR1 was associated with the susceptibility and severity of EV71 HFMD in Chinese Han populations, acting as a functional polymorphism by regulating ISGs expression, such as OAS1 and MX1.

  8. EV71病毒特异性单克隆抗体的筛选及鉴定

    Institute of Scientific and Technical Information of China (English)

    李静; 蔡芳; 高强; 王宾

    2009-01-01

    目的:筛选高亲和力和高中和活性的抗EV71病毒的单克隆抗体(mAb), 并对其特异性和抗原表位进行鉴定.方法:采用葡萄球菌A蛋白亲和层析法纯化mAb, 并进行抗体的中和效价、交叉反应性以及表位进行分析.结果:筛选出1株抗EV71病毒的mAb, 纯度大于95%, 抗体滴度达到10-7, 对EV71病毒具有广谱中和特性, 与CA16无交叉反应, 为VP1特异性, 并识别EV71的构象型表位.结论:筛选出1株具有高亲和力和中和活性的EV71病毒的mAb, 为研制EV71病毒感染性疾病的诊断试剂提供了重要工具, 并为研制治疗性mAb提供了条件.

  9. [Construction of cDNA infectious clones of EV71 highly-pathogenic and cell-culture-adapted strains].

    Science.gov (United States)

    Zhang, Yong-xin; Li, Xiao-yu; Huang, Yu-ming; Zhou, Yong-dong; Bi, Sheng-li; Cen, Shan

    2014-11-01

    The highly-pathogenic EV71 strain is the primary cause of mortality in hand-foot-and-mouth disease (HFMD) associated with neurological symptoms, for which no clinically effective drugs or vaccines exist. This study aimed to construct infectious cDNA clones of the EV71 highly-pathogenic strain and the cell-culture adapted strain using a reverse genetics approach. The genomic RNAs of EV71 parent strains were used as the templates for RT-PCR amplification, and then the PCR products that overlapped the full-length genome were connected into the pBR322 vector to produce infectious clones of pEV71 (HP) and pEV71 (CCA), respectively. The results showed that the HP strain propagated much more quickly than the CCA strain. The rescued viruses derived from the infectious clones not only maintained their consistency with their parent strains in terms of genomic sequences, but also retained their respective biological phenotypes. This research will contribute to our understanding of EV71 pathogenesis and the development of novel vaccines against HFMD.

  10. Out-of-plane (e , 2 e) measurements on He autoionizing levels at 80, 150, and 488 eV

    Science.gov (United States)

    Martin, N. L. S.; Kim, B. N.; Weaver, C. M.; Deharak, B. A.; Bartschat, K.

    2016-05-01

    We report out-of-scattering-plane (e , 2 e) measurements on helium 2 l 2l' autoionizing levels for 80, 150, and 488 eV incident electron energies, and scattering angles 60°, 39. 2°, and 20. 5°, respectively. The kinematics are the same in all cases: ejected electrons are detected in a plane that contains the momentum transfer direction and is perpendicular to the scattering plane, and the momentum transfer is 2.1 a.u.. The 80 eV results complete our sets of measurements at low, intermediate, and high, incident energies. The results are presented as (e , 2 e) angular distributions energy-integrated over each level, and are compared with our theory calculated for 488 eV incident electron energy. The 150 eV and 488 eV experiments are characterized by recoil peaks appropriate to each autoionizing level. However, for the 80 eV angular distributions, these recoil peaks are largely absent for all levels, including the 3 P level observed at this energy. This work was supported by the National Science Foundation under Grants Nos. PHY-0855040 (NLSM), PHY-1402899 (BAdH), and PHY-1212450 (KB).

  11. Technical note: An improved estimate of uncertainty for source contribution from effective variance Chemical Mass Balance (EV-CMB) analysis

    Science.gov (United States)

    Shi, Guo-Liang; Zhou, Xiao-Yu; Feng, Yin-Chang; Tian, Ying-Ze; Liu, Gui-Rong; Zheng, Mei; Zhou, Yang; Zhang, Yuan-Hang

    2015-01-01

    The CMB (Chemical Mass Balance) 8.2 model released by the USEPA is a commonly used receptor model that can determine estimated source contributions and their uncertainties (called default uncertainty). In this study, we propose an improved CMB uncertainty for the modeled contributions (called EV-LS uncertainty) by adding the difference between the modeled and measured values for ambient species concentrations to the default CMB uncertainty, based on the effective variance least squares (EV-LS) solution. This correction reconciles the uncertainty estimates for EV and OLS regression. To verify the formula for the EV-LS CMB uncertainty, the same ambient datasets were analyzed using the equation we developed for EV-LS CMB uncertainty and a standard statistical package, SPSS 16.0. The same results were obtained by both ways indicate that the equation for EV-LS CMB uncertainty proposed here is acceptable. In addition, four ambient datasets were studies by CMB 8.2 and the source contributions as well as the associated uncertainties were obtained accordingly.

  12. Smart Grid Charging of Electric Vehicles: EV-Owner Response to Scheduling and Pricing under Myopic Loss Aversion in an Ultimatum Two-Player Game

    DEFF Research Database (Denmark)

    Fetene, Gebeyehu Manie; Kaplan, Sigal; Sebald, Alexander Christopher;

    2015-01-01

    Upward expectations of future electric vehicle (EV) growth pose the question about the future load on the electricity grid. While the literature on demand side management of EV charging has focused on technical aspects and considered EV-owners as utility maximizers, this study looks at the neglec...

  13. A study on anti-EV71 virus in vitro of 10 kinds of common fruit juice%10种常见水果果汁体外抗EV71病毒研究

    Institute of Scientific and Technical Information of China (English)

    张炳丽; 康真; 梁爽; 李然; 宋晓琳; 范荣军

    2015-01-01

    Objective To observe the inhibitory effect of 10 kinds of common fruit juice on cytopathic effect (CPE) caused by hand, foot and mouth EV71 virus. Methods The cytotoxicity of 10 kinds of common juice to Hep Ⅱ was determined by MTT assay. The inhibitory effect of 10 kinds of common juice on hand, foot and mouth EV71 virus was studied by cell culture in vitro within the maximum non-toxic concentration of cells (MNCC). Then inhibitory concentration 50 (IC50) values of apple juice and grape juice for EV71 virus were calculated. Results Apple juice and grape juice with the function of anti-hand,foot and mouth EV71 virus were selected from 10 kinds of common juice. The IC50 values were respectively 1.652 times dilution and 9.965 times dilution of the original fruit juice. Conclusion Apple juice and grape juice have a research value of further selecting effective components of anti-EV71 virus.%目的:观察10种常见水果果汁对手足口 EV71病毒所引起细胞病变(CPE)的抑制作用。方法采用MTT 比色法,测定10种常见水果果汁对 Hep Ⅱ细胞的细胞毒性,并在对细胞的最大无毒浓度(MNCC)范围内,采用体外细胞培养法研究10种常见水果果汁对手足口 EV71病毒病毒的抑制作用。在此基础上计算出苹果汁和葡萄汁对 EV71病毒的半数抑制浓度的 IC50值。结果在10种常见水果果汁中筛选出苹果汁和葡萄汁两种具有抗手足口 EV71病毒作用的果汁,其 IC50值分别为果汁原液的1.652倍稀释液和9.965倍稀释液。结论苹果汁和葡萄汁具有进一步筛选抗 EV71病毒有效成分的研究价值。

  14. 10种常见水果果汁体外抗EV71病毒研究%A study on anti-EV71 virus in vitro of 10 kinds of common fruit juice

    Institute of Scientific and Technical Information of China (English)

    张炳丽; 康真; 梁爽; 李然; 宋晓琳; 范荣军

    2015-01-01

    目的:观察10种常见水果果汁对手足口 EV71病毒所引起细胞病变(CPE)的抑制作用。方法采用MTT 比色法,测定10种常见水果果汁对 Hep Ⅱ细胞的细胞毒性,并在对细胞的最大无毒浓度(MNCC)范围内,采用体外细胞培养法研究10种常见水果果汁对手足口 EV71病毒病毒的抑制作用。在此基础上计算出苹果汁和葡萄汁对 EV71病毒的半数抑制浓度的 IC50值。结果在10种常见水果果汁中筛选出苹果汁和葡萄汁两种具有抗手足口 EV71病毒作用的果汁,其 IC50值分别为果汁原液的1.652倍稀释液和9.965倍稀释液。结论苹果汁和葡萄汁具有进一步筛选抗 EV71病毒有效成分的研究价值。%Objective To observe the inhibitory effect of 10 kinds of common fruit juice on cytopathic effect (CPE) caused by hand, foot and mouth EV71 virus. Methods The cytotoxicity of 10 kinds of common juice to Hep Ⅱ was determined by MTT assay. The inhibitory effect of 10 kinds of common juice on hand, foot and mouth EV71 virus was studied by cell culture in vitro within the maximum non-toxic concentration of cells (MNCC). Then inhibitory concentration 50 (IC50) values of apple juice and grape juice for EV71 virus were calculated. Results Apple juice and grape juice with the function of anti-hand,foot and mouth EV71 virus were selected from 10 kinds of common juice. The IC50 values were respectively 1.652 times dilution and 9.965 times dilution of the original fruit juice. Conclusion Apple juice and grape juice have a research value of further selecting effective components of anti-EV71 virus.

  15. Torque blending and wheel slip control in EVs with in-wheel motors

    Science.gov (United States)

    de Castro, Ricardo; Araújo, Rui E.; Tanelli, Mara; Savaresi, Sergio M.; Freitas, Diamantino

    2012-01-01

    Among the many opportunities offered by electric vehicles (EVs), the design of power trains based on in-wheel electric motors represents, from the vehicle dynamics point of view, a very attractive prospect, mainly due to the torque-vectoring capabilities. However, this distributed propulsion also poses some practical challenges, owing to the constraints arising from motor installation in a confined space, to the increased unsprung mass weight and to the integration of the electric motor with the friction brakes. This last issue is the main theme of this work, which, in particular, focuses on the design of the anti-lock braking system (ABS). The proposed structure for the ABS is composed of a tyre slip controller, a wheel torque allocator and a braking supervisor. To address the slip regulation problem, an adaptive controller is devised, offering robustness to uncertainties in the tyre-road friction and featuring a gain-scheduling mechanism based on the vehicle velocity. Further, an optimisation framework is employed in the torque allocator to determine the optimal split between electric and friction brake torque based on energy performance metrics, actuator constraints and different actuators bandwidth. Finally, based on the EV working condition, the priorities of this allocation scheme are adapted by the braking supervisor unit. Simulation results obtained with the CarSim vehicle model, demonstrate the effectiveness of the overall approach.

  16. Evaluation of E/EV/SE aptitude to very long duration. Final report of working groups

    International Nuclear Information System (INIS)

    A joint COGEMA/CEA action aims at evaluating the conditions allowing the extension beyond 50 years of the exploitation of the E/EV/SE vitrified wastes storage facility of the UP3 factory of La Hague (France). The approach considered consists in analysing the technical and administrative aspects of the facility in order to determine the changes to be implemented for its qualification as very long storage facility. Three target characteristics have been identified as priorities for this analysis: safety, civil engineering, and cooling ventilation of wells, and thus three working groups have been created. According to works carried out, facilities like the E/EV/SE one are designed in such a way that their durability can reach the century scale: the robustness of the cooling process, the passiveness of most equipments and the limitation of components functions are the main strong points. Service life limitations come mainly from the thermal evolution of waste packages and the aging of components under the climate conditions: risk of atmospheric corrosion of the bottom part of wells under the effect of water condensation, and risk of corrosion of concrete reinforcements. Suggestions of improvement of the quantification and understanding of phenomena influencing the lifetime limitation are made, and some possible technical solutions are proposed. (J.S.)

  17. The Cosmic Ray Anisotropy between 1014 and 1015 eV

    Science.gov (United States)

    Aglietta, M.; Alessandron, B.; Antonioli, P.; Arneodo, F.; Bergamasco, L.; Bertaina, M.; Castagnoli, C.; Castellina, A.; Chiavassa, A.; Castagnoli, G. C.; D'Ettore Piazzoli, B.; Di Sciascio, G.; Fulgione, W.; Galeotti, P.; Ghia, P. L.; Iacovacci, M.; Mannocchi, G.; Morello, C.; Navarra, G.; Saavedra, O.; Trinchero, G. C.; Valchierotti, S.; Vallania, P.; Vernetto, S.; Vigorito, C.; EAS-TOP Collaboration

    2003-07-01

    The study of the anisotropy of the arrival directions is an essential and complementary to ol, with respect to the energy spectrum and composition, to investigate the origin and propagation of cosmic rays primaries. In particular, the study of the evolution of the CR anisotropy over primary energy can be very powerful for the interpretation of the knee in the CR primary spectrum. By means of the EAS-TOP data (four years) we have reported an anisotropy measurement at primary energy E0 ≈ 1014 eV [1], with amplitude Asid,δ=0° = (3.7 ± 0.6) · 10-4 and phase φ = (1.8 ± 0.5) hr LST, at a significance level 6.5 s.d. The use of the full EAS-TOP data set and the application of different criteria of data selection allow to extend this measurement to higher energies, up to around 1015 eV. We report here the results of the first harmonic analysis, both in solar and sidereal time, in five energy bins.

  18. Range Selection and Median

    DEFF Research Database (Denmark)

    Jørgensen, Allan Grønlund; Larsen, Kasper Green

    2011-01-01

    Range selection is the problem of preprocessing an input array A of n unique integers, such that given a query (i; j; k), one can report the k'th smallest integer in the subarray A[i];A[i+1]; : : : ;A[j]. In this paper we consider static data structures in the word-RAM for range selection...... selection problem. In the former, data structures must support prex selection queries under the assumption that k for some value n given at construction time, while in the latter, data structures must support range selection queries where k is xed beforehand for all queries. We prove cell probe lower bounds...... for range selection, prex selection and range median, stating that any data structure that uses S words of space needs (log n= log(Sw=n)) time to answer a query. In particular, any data structure that uses n logO(1) n space needs (log n= log log n) time to answer a query, and any data structure...

  19. Reconfigurable laser ranging instrument

    Science.gov (United States)

    Schneiter, John

    1994-03-01

    This paper describes the design and operation of a fast, flexible, non-contact, eye-safe laser ranging instrument useful in a variety of industrial metrology situations, such as in-process machining control and part inspection. The system has variable computer-controlled standoff and depth of field, and can obtain 3-D images of surfaces within a range of from 1.5 ft to almost 10 ft from the final optical element. The minimum depth of field is about 3.5 in. at 1.5 ft and about 26 in. at the far range. The largest depth of field for which useful data are available is about 41 in. Resolution, with appropriate averaging, is about one part in 4000 of the depth of field, which implies a best case resolution for this prototype of 0.00075 in. System flexibility is achieved by computer controlled relative positioning of optical components.

  20. Reactive scattering of O and H2 and quenching of OH at collision energies up to 4.4 eV

    Science.gov (United States)

    Gacesa, Marko; Kharchenko, Vasili

    2016-05-01

    We report new cross sections for the O(3 P) + H2 reactive scattering as well as quenching rates for rotationally and vibrationally excited OH by H atoms for a range of collision energies from 0.4 and 4.4 eV. These processes are important for understanding non-local thermal equilibrium (non-LTE) regime in astrophysical environment such as photon-dominated regions (PDRs) and evolution of planetary atmospheres in time, including the atmospheres of Earth and Mars. The cross sections were calculated quantum mechanically using coupled-channel formalism implemented in MOLSCAT and ABC computer codes on refitted recent potential energy surfaces for 3A' and 3A'' , while the surface-hopping effects were estimated from models and similar atom-molecule reactions. A large basis set was used to ensure the convergence at higher energies. Our results agree well with the published data at lower energies and indicate that reduced-dimensionality approach at collision energies higher than about 1.5 eV may not be adequate. Differential cross sections and diffusion cross sections, of interest in transport calculations, are also reported. This work was been supported by NASA grant NNX10AB88G.

  1. A large light-mass component of cosmic rays at 10^{17} - 10^{17.5} eV from radio observations

    CERN Document Server

    Buitink, S; Falcke, H; Hörandel, J R; Huege, T; Nelles, A; Rachen, J P; Rossetto, L; Schellart, P; Scholten, O; ter Veen, S; Thoudam, S; Trinh, T N G; Anderson, J; Asgekar, A; Avruch, I M; Bell, M E; Bentum, M J; Bernardi, G; Best, P; Bonafede, A; Breitling, F; Broderick, J W; Brouw, W N; Brüggen, M; Butcher, H R; Carbone, D; Ciardi, B; Conway, J E; de Gasperin, F; de Geus, E; Deller, A; Dettmar, R -J; van Diepen, G; Duscha, S; Eislöffel, J; Engels, D; Enriquez, J E; Fallows, R A; Fender, R; Ferrari, C; Frieswijk, W; Garrett, M A; Griessmeier, J M; Gunst, A W; van Haarlem, M P; Hassall, T E; Heald, G; Hessels, J W T; Hoeft, M; Horneffer, A; Iacobelli, M; Intema, H; Juette, E; Karastergiou, A; Kondratiev, V I; Kramer, M; Kuniyoshi, M; Kuper, G; van Leeuwen, J; Loose, G M; Maat, P; Mann, G; Markoff, S; McFadden, R; McKay-Bukowski, D; McKean, J P; Mevius, M; Mulcahy, D D; Munk, H; Norden, M J; Orru, E; Paas, H; Pandey-Pommier, M; Pandey, V N; Pietka, M; Pizzo, R; Polatidis, A G; Reich, W; Röttgering, H J A; Scaife, A M M; Schwarz, D J; Serylak, M; Sluman, J; Smirnov, O; Stappers, B W; Steinmetz, M; Stewart, A; Swinbank, J; Tagger, M; Tang, Y; Tasse, C; Toribio, M C; Vermeulen, R; Vocks, C; Vogt, C; van Weeren, R J; Wijers, R A M J; Wijnholds, S J; Wise, M W; Wucknitz, O; Yatawatta, S; Zarka, P; Zensus, J A

    2016-01-01

    Cosmic rays are the highest energy particles found in nature. Measurements of the mass composition of cosmic rays between 10^{17} eV and 10^{18} eV are essential to understand whether this energy range is dominated by Galactic or extragalactic sources. It has also been proposed that the astrophysical neutrino signal comes from accelerators capable of producing cosmic rays of these energies. Cosmic rays initiate cascades of secondary particles (air showers) in the atmosphere and their masses are inferred from measurements of the atmospheric depth of the shower maximum, Xmax, or the composition of shower particles reaching the ground. Current measurements suffer from either low precision, or a low duty cycle and a high energy threshold. Radio detection of cosmic rays is a rapidly developing technique, suitable for determination of Xmax with a duty cycle of in principle nearly 100%. The radiation is generated by the separation of relativistic charged particles in the geomagnetic field and a negative charge exces...

  2. IceCube astrophysical neutrinos without a spectral cutoff and (10^15-10^17) eV cosmic gamma radiation

    CERN Document Server

    Kalashev, O E

    2014-01-01

    We present a range of unbroken power-law fits to the astrophysical-neutrino spectrum consistent with the most recent published IceCube data at the 68\\% confidence level. Assuming that the neutrinos originate in decays of pi mesons, we estimate accompanying gamma-ray fluxes for various distributions of sources, taking propagation effects into account. We then briefly discuss existing experimental results constraining PeV to EeV diffuse gamma-ray flux and their systematic uncertainties. Several scenarios are marginally consistent both with the KASKADE and CASA-MIA upper limits at (10^15-10^16) eV and with the EAS-MSU tentative detection at ~10^17 eV, given large systematic errors of the measurements. Future searches for the diffuse gamma-ray background at sub-PeV to sub-EeV energies just below present upper limits will give a crucial diagnostic tool for distinguishing between the Galactic and extragalactic models of the origin of the IceCube events.

  3. Analysis of Carrier Recombination Processes in 0.6 eV InGaAs Epitaxial Materials for Thermophotovoltaic Devices

    International Nuclear Information System (INIS)

    Minority carrier lifetime was measured by time-resolved photoluminescence (TRPL) method in sets of p-type and n-type InGaAs double heterostructures (DH) moderately doped with Zn and Te, respectively. Contributions of the radiative and non-radiative recombination terms were separated by fitting experimental data to temperature dependences of the radiative term. The latter was modeled with measured fundamental absorption spectrum and the temperature dependence of the photon recycling effect was taken into account. Different temperature dependences of radiative terms for electron and hole materials were obtained. It was concluded that in 0.6 eV Te-doped InGaAs structures the radiative recombination controls the hole lifetime at liquid nitrogen temperatures, while Auger recombination dominates at room and above room temperatures. In similar 0.6 eV InGaAs with Zn-doped active regions Shockley-Read-Hall (SRH) recombination was found dominant in a wide temperature range from liquid nitrogen to above-room temperatures. Rapid decrease of electron lifetime with decrease of excess carrier concentration was observed and attributed to recombination through partially-ionized deep donor centers. The obtained data allows for more adequate modeling of the performance and design optimization of narrow-gap photonic devices based on InGaAs Indium-rich compounds

  4. Histopathological features and distribution of EV71 antigens and SCARB2 in human fatal cases and a mouse model of enterovirus 71 infection.

    Science.gov (United States)

    Yu, Pin; Gao, Zifen; Zong, Yuanyuan; Bao, Linlin; Xu, Lili; Deng, Wei; Li, Fengdi; Lv, Qi; Gao, Zhancheng; Xu, Yanfeng; Yao, Yanfeng; Qin, Chuan

    2014-08-30

    Enterovirus 71 (EV71) is a neurotropic pathogen that causes hand, foot, and mouth disease. While infection is usually self-limiting, a minority of patients infected with EV71 develop severe neurological complications. In humans, EV71 has been reported to utilize the scavenger receptor class B, member 2 (SCARB2) as a receptor for infectious cellular entry. In this study, we define the pathological features of EV71-associated disease as well as the distribution of EV71 antigen and SCARB2 in human fatal cases and a mouse model. Histopathologically, human fatal cases showed severe central nervous system (CNS) changes, mainly in the brainstems, spinal cords, and thalamus. These patient further exhibited pulmonary edema and necrotic enteritis. Immunohistochemical analysis of human fatal cases demonstrated that EV71 antigen and SCARB2 were observed mainly in neurons, microglia cells and inflammatory cells in the CNS, and epithelial cells in the intestines. However, skeletal muscle tissue was negative for EV71 antigen. In a mouse model of EV71 infection, we observed massive necrotic myositis, different degrees of viral diseases in CNS, and extensive interstitial pneumonia. In mice, EV71 exhibits strong myotropism compared to the neurotropism seen in humans. EV71 antigen was detected in the spinal cord and brainstem of mice. However, there was no clear correlation between mouse SCARB2 and EV71 antigen distribution in the mouse model, consistent with previous results that SCARB2 functions as a receptor for EV71 in humans but not mice. The EV71-induced lesions seen in the mouse model resembled the pathological changes seen in human samples. These results increase our understanding of EV71 pathogenesis and will inform further work developing a mouse model for EV71 infection.

  5. Institutional Long Range Planning.

    Science.gov (United States)

    Caldwell Community Coll. and Technical Inst., Lenoir, NC.

    Long-range institutional planning has been in effect at Caldwell Community College and Technical Institute since 1973. The first step in the process was the identification of planning areas: administration, organization, educational programs, learning resources, student services, faculty, facilities, maintenance/operation, and finances. The major…

  6. LONG RANGE HEALTH PLANNING

    Directory of Open Access Journals (Sweden)

    ST. Motameni

    1974-03-01

    Full Text Available In the past, health planning in Iran has been carried out in the context of short-range economic plans. Although this mechanism has helped a great deal in the achievement of certain health plans however, the said scheme has been short in meeting the health objectives on a comprehensive basis. Most often, the heath programs have lost their values to the priority and cost effectiveness of economic plans. A brief review of heath planning in the past shows that the second development plan has been devoted to the establishment of new hospitals on a scattered pattern. The development of a coordinated hospital and health center system has been accepted and partly implemented during the third plan period. In the fourth plan the whole direction has changed towards the de­velopment of private hospitals on profit making basis, and now the fifth plan calls for the regionalized hospital system. Thus, one can say that the past twenty years have been spent to the experimentation of different schemes with­out a real long-range goal. In the past decade the World Health Organization has ventured in the development of health planning principles, but most of the efforts have been devoted to the short-range planning. The long-range health planning is not only a new look to the prin­ciples of planning, but a thorough examination of the time factor in health planning.

  7. Agriculture, forest, and range

    Science.gov (United States)

    1975-01-01

    The findings and recommendations of the panel for developing a satellite remote-sensing global information system in the next decade are reported. User requirements were identified in five categories: (1) cultivated crops, (2) land resources, (3)water resources, (4)forest management, and (5) range management. The benefits from the applications of satellite data are discussed.

  8. Online Sorted Range Reporting

    DEFF Research Database (Denmark)

    Brodal, Gerth Stølting; Fagerberg, Rolf; Greve, Mark;

    2009-01-01

    We study the following one-dimensional range reporting problem: On an arrayA of n elements, support queries that given two indices i ≤ j and an integerk report the k smallest elements in the subarray A[i..j] in sorted order. We present a data structure in the RAM model supporting such queries in ...

  9. Electric vehicles: Driving range

    Science.gov (United States)

    Kempton, Willett

    2016-09-01

    For uptake of electric vehicles to increase, consumers' driving-range needs must be fulfilled. Analysis of the driving patterns of personal vehicles in the US now shows that today's electric vehicles can meet all travel needs on almost 90% of days from a single overnight charge.

  10. Agriculture, forestry, range resources

    Science.gov (United States)

    Macdonald, R. B.

    1974-01-01

    The necessary elements to perform global inventories of agriculture, forestry, and range resources are being brought together through the use of satellites, sensors, computers, mathematics, and phenomenology. Results of ERTS-1 applications in these areas, as well as soil mapping, are described.

  11. Optical properties of Cd0.9Zn0.1Te studied by variable angle spectroscopic ellipsometry between 0.75 and 6.24 eV

    International Nuclear Information System (INIS)

    Optical properties of Cd0.9Zn0.1Te (CZT) were studied by variable angle spectroscopic ellipsometry (VASE). Measurements made by VASE were performed on CZT and CdTe samples in air at room temperature at multiple angles of incidence. A parametric function model was employed in the VASE analysis to determine the dielectric functions (varepsilon)=(varepsilon)1 + i(varepsilon)2 in the range of 0.75 to 6.24 eV. A two-oscillator analytical model was used to describe the dielectric response of native oxides on CZT. Surface oxide optical properties and thickness on CZT were also determined in conjunction with the VASE measurement and analysis of a CdTe sample. Two samples of CZT of different oxide thicknesses were measured and their optical constants were coupled together in a multiple-sample, multiple-model VASE analysis to resolve correlations between fitting parameters. Effective medium approximation (EMA) was used to describe the optical properties of the CZT oxide with roughness. A Kramers-Kronig self-consistency check of the real and imaginary parts of the Cd0.9Zn0.1 dielectric functions was performed over the energy range 0.75 to 6.24 eV. A five-Lorentz-oscillator model was employed to describe the dielectric response of CZT in the range of 1.6 to 6.24 eV. Intensity transmission measurements were made on the Cd0.9Zn0.1Te and CdTe, showing the absorption energy band edges of ∼ 1.58 and 1.46 eV, respectively

  12. High-resolution beamline 9.3.2 in the energy range 30 endash 1500 eV at the Advanced Light Source: Design and performance

    International Nuclear Information System (INIS)

    Bending magnet beamline 9.3.2 at the Advanced Light Source (ALS) was designed for high resolution spectroscopy with the capability for delivering circularly polarized light in the soft x-ray energy region using three gratings. The monochromator is a fixed included-angle spherical grating monochromator (SGM) and was originally used at SSRL as a prototype for later insertion-device-based monochromators for the ALS. For operation at the ALS, the toroidal pre-mirror used at SSRL was replaced by a horizontally focusing and a vertically focusing mirror in the Kirkpatrick-Baez configuration. Circularly polarized radiation is obtained by inserting a water-cooled movable aperture in front of the vertically focusing mirror to allow selecting the beam either above or below the horizontal plane. To maintain a stable beam intensity through the entrance slit, the photocurrent signals from the upper and lower jaws of the entrance slit are utilized to set a feedback loop with the vertically deflecting mirror piezoelectric drive. The beamline end station has a movable platform that accommodates two experimental chambers enabling the synchrotron radiation to be directed to either one of the two experimental chambers without breaking the vacuum. copyright 1996 American Institute of Physics

  13. Charge changing cross sections for heavy-particle collisions in the energy range from 0.1 eV to 10 MeV, 1

    International Nuclear Information System (INIS)

    This paper presents a compilation of the experimental works on charge changing cross sections for neutral atoms, negative- and positive-atomic ions of atomic numbers Z = 2 - 5 in collisions with atoms and simple molecules. A systematic survey of the literature has been made through October 1977. Some recent data are also included. The result is summarized in graphical forms with reference lists attached. (author)

  14. A new calculation on the stopping power and mean free path for low energy electrons in toluene over energy range of 20-10000 eV.

    Science.gov (United States)

    Tan, Zhenyu; Xia, Yueyuan; Liu, Xiangdong; Zhao, Mingwen; Zhang, Liming

    2009-04-01

    A new calculation of the stopping powers (SP) and inelastic mean free paths (IMFP) for electrons in toluene at energies below 10 keV has been presented. The calculation is based on the dielectric model and on an empirical evaluation approach of optical energy loss function (OELF). The reliability for the evaluated OELFs of several hydrocarbons with available experimental optical data has been systematically checked. For toluene, using the empirical OELF, the evaluated mean ionization potential, is compared with that given by Bragg's rule, and the calculated SP at 10 keV is also compared with the Bethe-Bloch prediction. The present results for SP and IMFP provide an alternative basic data for the study on the energy deposition of low-energy electrons transport through toluene, and also show that the method used in this work may be a good one for evaluating the SP and IMFP for hydrocarbons. PMID:19138526

  15. IGSN e.V.: Registration and Identification Services for Physical Samples in the Digital Universe

    Science.gov (United States)

    Lehnert, K. A.; Klump, J.; Arko, R. A.; Bristol, S.; Buczkowski, B.; Chan, C.; Chan, S.; Conze, R.; Cox, S. J.; Habermann, T.; Hangsterfer, A.; Hsu, L.; Milan, A.; Miller, S. P.; Noren, A. J.; Richard, S. M.; Valentine, D. W.; Whitenack, T.; Wyborn, L. A.; Zaslavsky, I.

    2011-12-01

    -for-profit organization, the IGSN e.V. (e.V. = 'Eingetragener Verein', legal status for a registered voluntary association in Germany), that defines the IGSN scope and syntax and maintains the IGSN Handle system, and (b) a Science Advisory Board that guides policies, technology, and best practices of the SESAR Sample Metadata Clearinghouse and Local Registration Agents. The IGSN e.V. is being incorporated in Germany at the GFZ Potsdam, a founding event is planned for the AGU Fall Meeting.

  16. Spatial Mapping of NEO 2008 EV5 Using Small Satellite Formation Flying and Steresoscopic Technology

    Science.gov (United States)

    Gonzalez, Juan; Singh Derewa, Chrishma

    2016-10-01

    NASA is currently developing the first-ever robotic Asteroid Redirect Robotic Mission (ARRM) to the near-Earth asteroid 2008 EV5 with the objective to capture a multi-ton boulder from the asteroids surface and use its mass to redirect its parent into a CIS lunar orbit where astronauts will study its physical and chemical composition.A critical step towards achieving this mission is to effectively map the target asteroid, identify the candidate boulder for retrieval and characterize its critical parameters. Currently, ARRM utilizes a laser altimeter to characterize the height of the boulders and mapping for final autonomous control of the capture. The proposed Lava-Kusha mission provides the increased of stereoscopic imaging and mapping, not only the Earthward side of the asteroid which has been observed for possible landing sites, but mapping the whole asteroid. LKM will enhance the fidelity of the data collected by the laser altimeter and gather improved topographic data for future Orion missions to 2008 EV5 once in cis lunar space.LKM consists of two low cost small satellites (6U) as a part of the ARRM. They will launch with ARRM as an integrated part of the system. Once at the target, this formation of pathfinder satellites will image the mission critical boulder to ensure the system design can support its removal. LKM will conduct a series of flybys prior to ARRM's rendezvous. LKMs stereoscopic cameras will provide detailed surveys of the boulder's terrain and environment to ensure ARRM can operate safely, reach the location and interface with the boulder. The LKM attitude control and cold gas propulsion system will enable formation maintenance maneuvers for global mapping of asteroid 2008 EV5 at an altitude of 100 km to a high-spatial resolution imaging altitude of 5 km.LKM will demonstrate formation flying in deep space and the reliability of stereoscopic cameras to precisely identify a specific target and provide physical characterization of an asteroid. An

  17. EV71抗原表位的研究方法及研究进展%Method for and advance in research on neutralizing epitope of EV71

    Institute of Scientific and Technical Information of China (English)

    高文超

    2014-01-01

    肠道病毒71型(Enterovirus 71,EV71)属于小RNA病毒科(Picornaradae)肠道病毒属(Enterovirus)的成员,是引起亚太地区手足口病暴发的主要病原体之一.EV71可引起严重的神经系统病变,对6岁以下儿童造成较高的死亡率.目前尚无上市的疫苗来预防EV71的感染.因此,研制EV71疫苗及治疗药物十分迫切.病毒中和表位是刺激机体产生特异性免疫反应的物质基础,研究其结构、功能对于疫苗的研发,特别是亚单位疫苗的研制、药物靶点筛选至关重要.本文主要对研究EV71抗原表位的方法及最新近况作一综述.

  18. Lunar Laser Ranging Science

    OpenAIRE

    Williams, James G.; Boggs, Dale H.; Turyshev, Slava G.; Ratcliff, J. Todd

    2004-01-01

    Analysis of Lunar Laser Ranging (LLR) data provides science results: gravitational physics and ephemeris information from the orbit, lunar science from rotation and solid-body tides, and Earth science. Sensitive tests of gravitational physics include the Equivalence Principle, limits on the time variation of the gravitational constant G, and geodetic precession. The equivalence principle test is used for an accurate determination of the parametrized post-Newtonian (PPN) parameter \\beta. Lunar...

  19. Back to the range

    Energy Technology Data Exchange (ETDEWEB)

    1977-01-01

    It is now over 100 years since the ''discovery'' of the livestock-supporting properties of the vegetation on what had been considered worthless, unclaimed land. And the 1.2 billion acres of range in the United States--more than half of the country's land mass--is currently being discovered all over again--this time to be a major, underutilized resource in the struggle to erase the world's food deficits and, at the same time, conserve energy and other resources. Agronomists and range scientists are developing energy data which suggest that, if consumer habits and tastes and the habits and practices to which the industry is geared are adaptable, beef can continue to provide the major portion of U.S. protein needs without draining grain supplies from the hungry abroad. The key to their strategy is obtaining greater productivity from the range. This generally appears to offer the advantage of reducing man-made energy inputs per pound of beef sharply below those required by the alternative: grain feeding. The strategy may entail changes, however, in the whole beef system--from the preferred slaughter size of an animal to the preferred marbling pattern in a roast. Such changes may be dictated by costs.

  20. Organic sonobuoy ranging

    Science.gov (United States)

    Felgate, Nick

    2002-11-01

    It is important that military vessels periodically check their passive signatures for vunerabilities. Traditionally, this is undertaken on a fixed range (e.g., AUTEC, BUTEC) with low noise conditions. However, for operational and cost reasons it is desirable to be able to undertake such measurements while the asset is operating in other areas using expendable buoys deployed by the vessel itself. As well as the wet-end hardware for such organic sonobuoy ranging systems (e.g., calibrated sonobuoys, calibrated data uplink channels), careful consideration is needed of the signal-processing required in the harsher environmental conditions of the open ocean. In particular, it is noted that the open ocean is usually much noisier, and the propagation conditions more variable. To overcome signal-to-noise problems, techniques such as Doppler-correction, zero-padding/peak-picking, and noise estimation/correction techniques have been developed to provide accurate and unbiased estimates of received levels. To estimate propagation loss for source level estimation, a model of multipath effects has been included with the ability for analysts to compare predicted and observed received levels against time/range and adjust modeling parameters (e.g., surface loss, bottom loss, source depth) to improve the fit.

  1. Towards optimal range medians

    DEFF Research Database (Denmark)

    Brodal, Gerth Stølting; Gfeller, Beat; Jørgensen, Allan Grønlund;

    2011-01-01

    We consider the following problem: Given an unsorted array of n elements, and a sequence of intervals in the array, compute the median in each of the subarrays defined by the intervals. We describe a simple algorithm which needs O(nlog k + klog n) time to answer k such median queries. This improves...... where the time per query is reduced to O(log n / log log n). We also give efficient dynamic variants of both data structures, achieving O(log2 n) query time using O(nlog n) space in the comparison model and O((log n/loglog n)2) query time using O(nlog n/log log n) space in the RAM model, and show...... that in the cell-probe model, any data structure which supports updates in O(logO(1)n) time must have Ω(log n/loglog n) query time. Our approach naturally generalizes to higher-dimensional range median problems, where element positions and query ranges are multidimensional - it reduces a range median query...

  2. Double-difference method to improve the resolution of an eV neutron spectrometer

    International Nuclear Information System (INIS)

    Epithermal (eV) neutron spectrometers designed to measure the dynamic properties of condensed matter have been developed at several pulsed neutron sources, using nuclear resonances to define neutron energy. The energy resolution of such a spectrometer is limited by the width of the nuclear resonance. The paper describes how a linear combination of measurements with two thicknesses of foils of the resonance material yields better energy resolution than either foil alone. With proper selection of foil thicknesses, there is no penalty in counting statistics to obtain the improved resolution. The double-difference method also suppresses the wings of the resonance and yields a function with a finite second moment so that uncertainties may be properly propagated. (orig.)

  3. EV-16 vitrification demonstration with surrogate Oak Ridge reservation K-25 B & C pond sludge

    Energy Technology Data Exchange (ETDEWEB)

    Cicero, C.A. [Westinghouse Savannah River Company, Aiken, SC (United States)

    1996-07-05

    The Mixed Waste Focus Area (MWFA) has chartered the Savannah River Technology Center (SRTC) to design and fabricate a Transportable Vitrification System (TVS) to demonstrate treatment of Low-Level Mixed Waste (LLMW). This system will be used to demonstrate the feasibility of vitrification on several LLMW streams. The first stream to be demonstrated will be the Oak Ridge Reservation (ORR) K-25 B&C Pond sludge. Before the demonstrations in the TVS can take place, a surrogate sludge vitrification demonstration had to be performed in the EV-16 melter located at the DOE Industrial Center for Vitrification Research (Center) at the Environmental Systems Engineering Department at Clemson University. During the demonstration at the Center, a 50 wt% B&C sludge glass composition was tested to determine any processing problems. A total of 1510 pounds (686 kg) of glass were produced from 9328 pounds (4240 kg) of surrogate feed. The resulting glass product was homogeneous and very durable.

  4. Inferring neutrino cross sections above 10^19 eV

    CERN Document Server

    Palomares-Ruiz, S

    2006-01-01

    Extremely high energy neutrinos propagating in the atmosphere or in the Earth can originate horizontal or upgoing air-showers, respectively. We calculate the acceptances (event rate/flux) for detecting both types of events by fluorescence detectors, both space-based as with the EUSO and OWL proposals, and ground-based, as with Auger, HiRes and Telescope Array. We depict them as a function of the neutrino-nucleon cross section and show that from the ratio of these two classes of events, the inference of the cross section above 10^{19} eV appears feasible, assuming that a neutrino flux exists at these energies. Our semi-analytic calculation includes realistic energy-losses for tau leptons and Earth-curvature effects. We also consider constraints on shower development and identification and the effects of a cloud layer.

  5. Damage of DNA by Low Energy Electrons (< 3 eV)

    International Nuclear Information System (INIS)

    Recent experiments on low energy electron attachment to DNA and its components in the condensed phase and in the gas phase are reviewed and analysed. From different condensed phase experiments the sensitivity of DNA towards low energy electrons is well documented and strand breaks in DNA are observed at subexcitation energies (< 3 eV) and also in ultrafast electron transfer experiments involving electrons in presolvated states. Gas phase experiments indicate that all building blocks of DNA (the nucleobases, the sugar and the phosphate moiety) undergo resonant dissociative electron attachment (DEA) in the subexcitation regime which may ultimately lead to strand breaks. From very recent gas phase experiments on an entire nucleotide it can be concluded that most strand breaks result from direct electron attachment to the DNA backbone, but also initial electron capture by the nucleobase following electron transfer to the backbone contributes.

  6. Electron Correlation in the Final Continuum of Ionization Hydrogen by 150-eV Electron Impact

    Institute of Scientific and Technical Information of China (English)

    张程华; 臧树良; 王晓伟; 王京阳

    2004-01-01

    Electron correlation in triple differential cross sections for ionization of atomic hydrogen by electron impact is analysed for the case of coplanar asymmetric geometry within the framework of the two-potential formulae. Based on the approximations of projectile and faster-electron plane wave, the transition matrix element is analytically expressed to be a product of two factors: the correlation factor of two electrons in the final channel and the structure-scattering factor. The contribution of both the factors to the angular distribution of the triple differential cross section is calculated. The present results are compared with the experimental data and the other theoretical calculations for the incident energy of 150 eV.

  7. MoS/sub 2/ interactions with 1--3 eV atomic oxygen

    Energy Technology Data Exchange (ETDEWEB)

    Martin, J.A.; Cross, J.B.; Pope, L.E.

    1988-01-01

    Exposures of MoS/sub 2/ to 1.5--3 eV atomic oxygen in an anhydrous environment reveal that the degree of oxidation is essentially independent of crystallite orientation and the surface adsorbed reaction products are MoO/sub 3/ and MoO/sub 2/. A mixture of oxides and sulfide exist over a depth of at least 100 /angstrom/ and this layer has a low diffusion rate for oxygen. It is concluded that a protective oxide layer will form on MoS/sub 2/ upon exposure to the atomic-oxygen-rich environment of low earth orbit. The tribological implications of these results are under investigation. 8 refs., 3 figs.

  8. Integrated Charger with Wireless Charging and Boost Function for PHEV and EV Applications

    Energy Technology Data Exchange (ETDEWEB)

    Chinthavali, Madhu Sudhan [ORNL; Onar, Omer C [ORNL; Campbell, Steven L [ORNL

    2015-01-01

    Integrated charger topologies that have been researched so far with dc-dc converters and the charging functionality have no isolation in the system. Isolation is an important feature that is required for user interface systems that have grid connections and therefore is a major limitation that needs to be addressed along with the integrated functionality. The topology proposed in this paper is a unique and a first of its kind topology that integrates a wireless charging system and the boost converter for the traction drive system. The new topology is also compared with an on-board charger system from a commercial electric vehicle (EV). The ac-dc efficiency of the proposed system is 85.05% and the specific power and power density of the onboard components is ~455 W/kg and ~302 W/ .

  9. Integrated Charger with Wireless Charging and Boost Function for PHEV and EV Applications

    Energy Technology Data Exchange (ETDEWEB)

    Chinthavali, Madhu Sudhan [ORNL; Onar, Omer C [ORNL; Campbell, Steven L [ORNL; Tolbert, Leon M [ORNL

    2015-01-01

    Integrated charger topologies that have been researched so far with dc-dc converters and the charging functionality have no isolation in the system. Isolation is an important feature that is required for user interface systems that have grid connections and therefore is a major limitation that needs to be addressed along with the integrated functionality. The topology proposed in this paper is a unique and a first of its kind topology that integrates a wireless charging system and the boost converter for the traction drive system. The new topology is also compared with an on-board charger system from a commercial electric vehicle (EV). The ac-dc efficiency of the proposed system is 85.1% and the specific power and power density of the onboard components is ~455 W/kg and ~320 W/ .

  10. Aktion Fischotterschutz e.V. (German Campaign for Otter Protection Activities 1991-92

    Directory of Open Access Journals (Sweden)

    Reuther C.

    1992-02-01

    Full Text Available Aktion Fischotterschutz e.V. (German Campaign for Otter Protection Activities 1991-92Pages 16 - 19 (ReportClaus ReutherFollowing reunification, the work of Aktion Fischotterschutz has intensified. In the east, due mainly to hunting reserves for politicians, otter populations and habitat is currently good. As the east reaps the benefit of reunification, and development begins, this is likely to rapidly change. We must act quickly to avoid the mistakes made in the past in the west. In West Germany, the focus is recovery of habitat, with a new project, Otter 2000, intended to reconnect isolated otter populations through the provision of habitat corridors. Reports on other projects are also presented.

  11. Theory of Multiphoton Multielectron Ionization of Xenon under Strong 93-eV Radiation

    International Nuclear Information System (INIS)

    We present a theoretical interpretation of recent experimental results on multiphoton multiple ionization of xenon by soft-x-ray radiation of photon energy ∼93 eV and intensity up to 1016 W/cm2[A. A Sorokin et al., Phys. Rev. Lett. 99, 213002 (2007)]. The data are interpreted within multiphoton perturbation theory, taking into account the spatiotemporal distribution of the radiation. Multiphoton cross sections have been obtained through a technique of scaling, with occasional adjustment to the data, provided the two prove to be compatible. Whatever discrepancies between theory and experiment persist can be reasonably attributed to some uncertainty in the experimental conditions and possibly to the value of some cross sections, without, however, any evidence for nonperturbative behavior

  12. Existence of unbiased estimate of regression parameters in simple linear EV models

    Institute of Scientific and Technical Information of China (English)

    LIU; Jixue

    2005-01-01

    It is well known that for one-dimensional normal EV regression model X = x +u, Y= α+βx+e, where x, u, e are mutually independent normal variables and Eu = Ee= 0,the regression parameters α andβ are not identifiable without some restriction imposed on the parameters. This paper discusses the problem of existence of unbiased estimate for α and β under some restrictions commonly used in practice. It is proved that the unbiased estimate does not exist under many such restrictions. We also point out one important case in which the unbiased estimates of α andβ exist, and the form of the MVUE of α and β are also given.

  13. Electrochemical efficiency in multiple discharge/recharge cycling of supercapacitors in hybrid EV applications

    Energy Technology Data Exchange (ETDEWEB)

    Pell, W.G.; Conway, B.E. [Carleton Univ., Ottawa, ON (Canada). Dept. of Chemistry; Adams, W.A.; Oliveira, J. de [ESTCO and IEA Electric Hybrid Vehicle Operating Agency, Nepean, ON (Canada)

    1999-07-01

    The use of large capacitance supercapacitors in series or series/parallel configurations has been envisaged and evaluated as a basis for load-levelling, and hence performance enhancement, in electric vehicles (EV) powered primarily by rechargeable batteries or fuel-cells. In this paper, charge/discharge efficiency in duty-cycles of the supercapacitor component are examined in relation to distributed resistance in porous double-layer and redox-type devices which restricts efficiency of discharge and recharge cycling, especially at high rates. Results of quantitative experiments on the responses of a five-element RC model hardware equivalent-circuit and a gold brush electrode are presented. Potential-recovery after discharge and potential-decay after recharge, and potential changes following load variations, enable efficiencies of charge delivery and acceptance to be evaluated. (orig.)

  14. 49th report of the Arbeitsgemeinschaft Rhein-Wasserwerke e.V.. Annual report 1992

    International Nuclear Information System (INIS)

    The annual report of the Arbeitsgemeinschaft Rhein-Wasserwerke (ARW) discusses the following subjects: (1) ARW report on water quality; (2) the problem of herbicides and pesticides; (3) Duesseldorf-Flehe Rhine river monitoring station - construction and performance; (4) observations concerning the aerobic degradation capacity of the river banks as a functional of the seasonal temperature variations of the Rhine; (5) results of Rhine water analyses of GEW-Werke Koeln AG in 1992; (6) statistical methods of generating groundwater levels in ground water aquifers under the influence of outfall ditches. The appendix contains the analyses of the year 1992, the data acquired by GEW-Werke Koeln AG for 1992, the 1993 monitoring programme, and a survey of the organisational structure of the Arbeitsgemeinschaft Rhein-Wasserwerke e.V. (orig./BRR)

  15. An explicit solution to the matrix equation AV+BW=EV J

    Institute of Scientific and Technical Information of China (English)

    Aiguo WU; Guangren DUAN; Bin ZHOU

    2007-01-01

    In this note,the matrix equation AV+BW=EV J is considered,where E,A and B are given matrices of appropriate dimensions,J is an arbitrarily given Jordan matrix,V and W are the matrices to be determined.Firstly,a right factorization of(sE-A)-1 B is given based on the Leverriver algorithm for descriptor systems.Then based on this factorization and a proposed parametric solution,an alternative parametric solution to this matrix equation is established in terms of the R-controllability matrix of(E,A,B),the generalized symmetric operator and the observability matrix associated with the Jordan matrix J and a free parameter matrix.The proposed results provide great convenience for many analysis and design problems.Moreover,some equivalent forms are proposed.A numerical example is employed to illustrate the effect of the proposed approach.

  16. Extensive Air Showers and Cosmic Ray Physics above 1017 eV

    Science.gov (United States)

    Bertaina, Mario

    2016-07-01

    Cosmic Rays above 1017 eV allow studying hadronic interactions at energies that can not be attained at accelerators yet. At the same time hadronic interaction models have to be applied to the cosmic-ray induced air-shower cascades in atmosphere to infer the nature of cosmic rays. The reliability of air-shower simulations has become the source of one of the largest systematic uncertainty in the interpretation of cosmic-ray data due to the uncertainties in modeling the hadronic interaction driving the air-shower development. This paper summarises in the first part the recent results on the cosmic ray energy spectrum, composition and anisotropy from the knee region to the GZK cutoff [1, 2] of the spectrum by means of ground-based experiments. Most of the information reported in this contribution is taken from [3-5]. Aspects interconnecting cosmic ray and particle physics are reviewed in the second part of the paper.

  17. Sampling the low-energy range of EEDF

    Science.gov (United States)

    Dahl, Dominik A.; Franck, Christian M.

    2011-10-01

    Electron swarms are investigated by the classical Pulsed Townsend Method in mixtures of N2/CO2 with controlled traces of SF6. The electron swarms are released from a back- illuminated photocathode by 1.5 ns FWHM laser pulses and drift in the homogeneous field of Rogowski electrodes. From an analysis of displacement currents the coefficient of electron attachment to gas molecules η is obtained. The pronounced s-wave attachment of SF6 acts on the electron swarm energy distribution (EEDF) by reducing the number of electrons in the energy range below 0.2 eV. It will be investigated if, vice versa, the observed η can be used as a measure for the EEDF in the range below 0.2 eV. The effect of the N2/CO2 mixing ratio on η will be measured and put in relation to the difference between N2 and CO2 concerning their elastic and inelastic cross sections. The goal is to provide data about that range of the EEDF which are not accessible by optical emission spectroscopy or by Langmuir probes.

  18. Antibody against extracellular vaccinia virus (EV protects mice through complement and Fc receptors.

    Directory of Open Access Journals (Sweden)

    Matthew E Cohen

    Full Text Available Protein-based subunit smallpox vaccines have shown their potential as effective alternatives to live virus vaccines in animal model challenge studies. We vaccinated mice with combinations of three different vaccinia virus (VACV proteins (A33, B5, L1 and examined how the combined antibody responses to these proteins cooperate to effectively neutralize the extracellular virus (EV infectious form of VACV. Antibodies against these targets were generated in the presence or absence of CpG adjuvant so that Th1-biased antibody responses could be compared to Th2-biased responses to the proteins with aluminum hydroxide alone, specifically with interest in looking at the ability of anti-B5 and anti-A33 polyclonal antibodies (pAb to utilize complement-mediated neutralization in vitro. We found that neutralization of EV by anti-A33 or anti-B5 pAb can be enhanced in the presence of complement if Th1-biased antibody (IgG2a is generated. Mechanistic differences found for complement-mediated neutralization showed that anti-A33 antibodies likely result in virolysis, while anti-B5 antibodies with complement can neutralize by opsonization (coating. In vivo studies found that mice lacking the C3 protein of complement were less protected than wild-type mice after passive transfer of anti-B5 pAb or vaccination with B5. Passive transfer of anti-B5 pAb or monoclonal antibody into mice lacking Fc receptors (FcRs found that FcRs were also important in mediating protection. These results demonstrate that both complement and FcRs are important effector mechanisms for antibody-mediated protection from VACV challenge in mice.

  19. Photofragmentation dynamics of gaseous dimethyl sulfoxide at 15 eV induced by synchrotron radiation

    Energy Technology Data Exchange (ETDEWEB)

    Guerra, A.C.O.; Leite, T.C.M.; Turci, C.C. [Universidade Federal do Rio de Janeiro (UFRJ), RJ (Brazil); Barros, A.L.F. de [Centro Federal de Educacao Tecnologica do Rio de Janeiro (CEFET-RJ), RJ (Brazil); Ferreira, G.B. [Universidade Federal Fluminense (UFF), Niteroi, RJ (Brazil)

    2012-07-01

    Full text: Dimethyl sulfoxide (DMSO) is a solvent widely used in chemical and biological laboratories and in industrial processes, as well. DMSO [(H{sub 3}C){sub 2} - SO] is a sulfur analog of acetone [(H{sub 3}C){sub 2} - CO]. Being the simplest alkyl sulfoxide, the DMSO is a model system for the understanding of more complex sulfoxide molecules. In this work the DMSO was excited with synchrotron light and the photoelectron-photoion coincidence spectrum was acquired at 15 eV. Our goal is to study the S-C bonding breaking process, especially in the H{sub 3}CSO{sup +} and CH{sub 3}{sup +} channels. The main question is how the 10a {yields} {infinity} transition affects the cleavage of S-C bond and consequently the production of those fragments. The experiments have been performed using the Toroidal Grating Monochromator (TGM) beamline at the Brazilian Synchrotron Light Laboratory (LNLS) in Campinas-SP (research proposal D05A-TGM-11047). High purity samples were obtained commercially and used without any further purification. They were introduced into the Wiley-McLaren time-of-flight mass spectrometer (TOF-MS) from the vapours of the room temperature liquids after removing air and volatile impurities by a series of freeze-pump-thaw cycles. The work pressure was maintained at 1:0 x 10{sup -6} mbar during data acquisition. The basis pressure was 1:0 x 10{sup -8} mbar. The results confirm that at 10a {yields} {infinity} transition the main produced fragment is the H{sub 3}CSO{sup +}. It means that at 15 eV the S-C bonding breaking is the principal photofragmentation process. (author)

  20. Study of the chemical composition of high energy cosmic rays using the muon LDF of EAS between $10^{17.25}$ eV and $10^{17.75}$ eV

    CERN Document Server

    Tapia, A; Sánchez, F; Croce, A Sedoski; Figueira, J M; García, B; González, N; Josebachuili, M; Ravignani, D; Wundheiler, B; Etchegoyen, A

    2015-01-01

    We explore the feasibility of estimating primary cosmic ray composition at high energies from the study of two parameters of Extensive Air Showers (EAS) at ground and underground level with Monte Carlo simulations using the new EPOS and QGSJETII hadronic models tuned with LHC data. Namely, the slope and density at a given distance of the muon lateral distribution function are analysed in this work. The power to discriminate primary masses is quantified in terms of merit factor for each parameter. The analysis considers three different primary particles (proton, iron and gamma), four different zenith angles (0$^{\\circ}$, 15$^{\\circ}$, 30$^{\\circ}$ and 45$^{\\circ}$) and primary energies of $10^{17.25}$ eV, $10^{17.50}$ eV and $10^{17.75}$ eV.

  1. A new animal model containing human SCARB2 and lacking stat-1 is highly susceptible to EV71

    Science.gov (United States)

    Liou, An-Ting; Wu, Szu-Yao; Liao, Chun-Che; Chang, Ya-Shu; Chang, Chih-Shin; Shih, Chiaho

    2016-01-01

    Enterovirus 71 (EV71) is a major threat to children worldwide. Children infected with EV71 could develop subclinical infection and hand-foot-and -mouth disease (HFMD). In severe cases, patients could develop encephalitis, paralysis, pulmonary edema, and death. A more user-friendly and robust animal model is essential to investigating EV71 pathogenesis. Here, we established a hybrid (hSCARB2+/+/stat-1−/−) mouse strain from crossbreeding SCARB2 transgenic and stat-1 KO mice, and compared the susceptibilities to EV71 infection and pathogenesis between parental and hybrid mice. Virus-encoded VP1 protein can be detected in the streaking nerve fibers in brain and spinal cord. This hybrid mouse strain at 2-week-old age can still be infected with different genotypes of EV71 at 1000-fold lower titer via an ip route. Infected hybrid mice developed earlier onset of CNS disease, paralysis, and death at a higher incidence. These advantages of this novel model meet the urgent need from the scientific community in basic and preclinical research in therapeutics and pathogenesis. PMID:27499235

  2. Display of the Viral Epitopes on Lactococcus lactis: A Model for Food Grade Vaccine against EV71

    Directory of Open Access Journals (Sweden)

    Nadimpalli Ravi S. Varma

    2013-01-01

    Full Text Available In this study, we have developed a system for display of antigens of Enterovirus type 71 (EV71 on the cell surface of L. lactis. The viral capsid protein (VP1 gene from a local viral isolate was utilized as the candidate vaccine for the development of oral live vaccines against EV71 using L. lactis as a carrier. We expressed fusion proteins in E. coli and purified fusion proteins were incubated with L. lactis. We confirmed that mice orally fed with L. lactis displaying these fusion proteins on its surface were able to mount an immune response against the epitopes of EV71. This is the first example of an EV71 antigen displayed on the surface of a food grade organism and opens a new perspective for alternative vaccine strategies against the EV71. We believe that the method of protein docking utilized in this study will allow for more flexible presentations of short peptides and proteins on the surface of L. lactis to be useful as a delivery vehicle.

  3. A new animal model containing human SCARB2 and lacking stat-1 is highly susceptible to EV71.

    Science.gov (United States)

    Liou, An-Ting; Wu, Szu-Yao; Liao, Chun-Che; Chang, Ya-Shu; Chang, Chih-Shin; Shih, Chiaho

    2016-01-01

    Enterovirus 71 (EV71) is a major threat to children worldwide. Children infected with EV71 could develop subclinical infection and hand-foot-and -mouth disease (HFMD). In severe cases, patients could develop encephalitis, paralysis, pulmonary edema, and death. A more user-friendly and robust animal model is essential to investigating EV71 pathogenesis. Here, we established a hybrid (hSCARB2(+/+)/stat-1(-/-)) mouse strain from crossbreeding SCARB2 transgenic and stat-1 KO mice, and compared the susceptibilities to EV71 infection and pathogenesis between parental and hybrid mice. Virus-encoded VP1 protein can be detected in the streaking nerve fibers in brain and spinal cord. This hybrid mouse strain at 2-week-old age can still be infected with different genotypes of EV71 at 1000-fold lower titer via an ip route. Infected hybrid mice developed earlier onset of CNS disease, paralysis, and death at a higher incidence. These advantages of this novel model meet the urgent need from the scientific community in basic and preclinical research in therapeutics and pathogenesis. PMID:27499235

  4. Genomic and immunologic factors associated with viral pathogenesis in a lethal EV71 infected neonatal mouse model.

    Science.gov (United States)

    Yue, Yingying; Li, Peng; Song, Nannan; Li, Bingqing; Li, Zhihui; Guo, Yuqi; Zhang, Weidong; Wei, Ming Q; Gai, Zhongtao; Meng, Hong; Wang, Jiwen; Qin, Lizeng

    2016-05-01

    Hand, foot and mouth disease (HFMD) caused by enterovirus 71 (EV71) has emerged as a major health problem in China and worldwide. The present study aimed to understand the virological features of EV71 and host responses resulting from EV71 infection. Six different EV71 strains were isolated from HFMD patients with severe or mild clinical symptoms, and were analyzed for pathogenicity in vitro and in vivo. The results demonstrated that the six virus strains exhibited similar cytopathogenic effects on susceptible MA104 cells. However, marked differences in histological and immunopathological changes were observed when mice were inoculated with the different virus strains. Thus, the viruses studied were divided into two groups, highly or weakly pathogenic. Two representative virus strains, JN200804 and JN200803 (highly and weakly pathogenic, respectively) were studied further to investigate pathogenicity-associated factors, including genetic mutations and immunopathogenesis. The present study has demonstrated that highly pathogenic strains have stable genome and amino acid sequences. Notably, the present study demonstrated that a highly pathogenic strain induced a significant increase of the bulk CD4 T cell levels at 3 days post‑inoculation. In conclusion, the current study demonstrates that genomic and immunologic factors may be responsible for the multiple tissue damage caused by highly pathogenic EV71 infection. PMID:27035332

  5. A new animal model containing human SCARB2 and lacking stat-1 is highly susceptible to EV71.

    Science.gov (United States)

    Liou, An-Ting; Wu, Szu-Yao; Liao, Chun-Che; Chang, Ya-Shu; Chang, Chih-Shin; Shih, Chiaho

    2016-01-01

    Enterovirus 71 (EV71) is a major threat to children worldwide. Children infected with EV71 could develop subclinical infection and hand-foot-and -mouth disease (HFMD). In severe cases, patients could develop encephalitis, paralysis, pulmonary edema, and death. A more user-friendly and robust animal model is essential to investigating EV71 pathogenesis. Here, we established a hybrid (hSCARB2(+/+)/stat-1(-/-)) mouse strain from crossbreeding SCARB2 transgenic and stat-1 KO mice, and compared the susceptibilities to EV71 infection and pathogenesis between parental and hybrid mice. Virus-encoded VP1 protein can be detected in the streaking nerve fibers in brain and spinal cord. This hybrid mouse strain at 2-week-old age can still be infected with different genotypes of EV71 at 1000-fold lower titer via an ip route. Infected hybrid mice developed earlier onset of CNS disease, paralysis, and death at a higher incidence. These advantages of this novel model meet the urgent need from the scientific community in basic and preclinical research in therapeutics and pathogenesis.

  6. Comparing the Primary and Recall Immune Response Induced by a New EV71 Vaccine Using Systems Biology Approaches.

    Science.gov (United States)

    Shao, Jie; Zhang, Junnan; Wu, Xing; Mao, Qunying; Chen, Pan; Zhu, Fengcai; Xu, Miao; Kong, Wei; Liang, Zhenglun; Wang, Junzhi

    2015-01-01

    Three inactivated EV71 whole-virus vaccines have completed Phase III clinical trials in mainland China, with high efficacy, satisfactory safety, and sustained immunogenicity. However, the molecular mechanisms how this new vaccine elicit potent immune response remain poorly understood. To characterize the primary and recall responses to EV71 vaccines, PBMC from 19 recipients before and after vaccination with EV71 vaccine are collected and their gene expression signatures after stimulation with EV71 antigen were compared. The results showed that primary and recall response to EV71 antigen have both activated an IRF7 regulating type I interferon and antiviral immune response network. However, up-regulated genes involved in T cell activation regulated by IRF1, inflammatory response, B-cell activation and humoral immune response were only observed in recall response. The specific secretion of IL-10 in primary response and IL-2,IP-10,CCL14a, CCL21 in recall response was consistent with the activation of immune response process found in genes. Furthermore, the expression of MX1 and secretion of IP-10 in recall response were strongly correlated with NTAb level at 180d after vaccination (r = 0.81 and 0.99). In summary, inflammatory response, adaptive immune response and a stronger antiviral response were indentified in recall response.

  7. Genomic and immunologic factors associated with viral pathogenesis in a lethal EV71 infected neonatal mouse model.

    Science.gov (United States)

    Yue, Yingying; Li, Peng; Song, Nannan; Li, Bingqing; Li, Zhihui; Guo, Yuqi; Zhang, Weidong; Wei, Ming Q; Gai, Zhongtao; Meng, Hong; Wang, Jiwen; Qin, Lizeng

    2016-05-01

    Hand, foot and mouth disease (HFMD) caused by enterovirus 71 (EV71) has emerged as a major health problem in China and worldwide. The present study aimed to understand the virological features of EV71 and host responses resulting from EV71 infection. Six different EV71 strains were isolated from HFMD patients with severe or mild clinical symptoms, and were analyzed for pathogenicity in vitro and in vivo. The results demonstrated that the six virus strains exhibited similar cytopathogenic effects on susceptible MA104 cells. However, marked differences in histological and immunopathological changes were observed when mice were inoculated with the different virus strains. Thus, the viruses studied were divided into two groups, highly or weakly pathogenic. Two representative virus strains, JN200804 and JN200803 (highly and weakly pathogenic, respectively) were studied further to investigate pathogenicity-associated factors, including genetic mutations and immunopathogenesis. The present study has demonstrated that highly pathogenic strains have stable genome and amino acid sequences. Notably, the present study demonstrated that a highly pathogenic strain induced a significant increase of the bulk CD4 T cell levels at 3 days post‑inoculation. In conclusion, the current study demonstrates that genomic and immunologic factors may be responsible for the multiple tissue damage caused by highly pathogenic EV71 infection.

  8. Display of the Viral Epitopes on Lactococcus lactis: A Model for Food Grade Vaccine against EV71.

    Science.gov (United States)

    Varma, Nadimpalli Ravi S; Toosa, Haryanti; Foo, Hooi Ling; Alitheen, Noorjahan Banu Mohamed; Nor Shamsudin, Mariana; Arbab, Ali S; Yusoff, Khatijah; Abdul Rahim, Raha

    2013-01-01

    In this study, we have developed a system for display of antigens of Enterovirus type 71 (EV71) on the cell surface of L. lactis. The viral capsid protein (VP1) gene from a local viral isolate was utilized as the candidate vaccine for the development of oral live vaccines against EV71 using L. lactis as a carrier. We expressed fusion proteins in E. coli and purified fusion proteins were incubated with L. lactis. We confirmed that mice orally fed with L. lactis displaying these fusion proteins on its surface were able to mount an immune response against the epitopes of EV71. This is the first example of an EV71 antigen displayed on the surface of a food grade organism and opens a new perspective for alternative vaccine strategies against the EV71. We believe that the method of protein docking utilized in this study will allow for more flexible presentations of short peptides and proteins on the surface of L. lactis to be useful as a delivery vehicle.

  9. Vulnerability to chronic subordination stress-induced depression-like disorders in adult 129SvEv male mice.

    Science.gov (United States)

    Dadomo, Harold; Sanghez, Valentina; Di Cristo, Luisana; Lori, Andrea; Ceresini, Graziano; Malinge, Isabelle; Parmigiani, Stefano; Palanza, Paola; Sheardown, Malcolm; Bartolomucci, Alessandro

    2011-08-01

    Exposure to stressful life events is intimately linked with vulnerability to neuropsychiatric disorders such as major depression. Pre-clinical animal models offer an effective tool to disentangle the underlying molecular mechanisms. In particular, the 129SvEv strain is often used to develop transgenic mouse models but poorly characterized as far as behavior and neuroendocrine functions are concerned. Here we present a comprehensive characterization of 129SvEv male mice's vulnerability to social stress-induced depression-like disorders and physiological comorbidities. We employed a well characterized mouse model of chronic social stress based on social defeat and subordination. Subordinate 129SvEv mice showed body weight gain, hyperphagia, increased adipose fat pads weight and basal plasma corticosterone. Home cage phenotyping revealed a suppression of spontaneous locomotor activity and transient hyperthermia. Subordinate 129SvEv mice also showed marked fearfulness, anhedonic-like response toward a novel but palatable food, increased anxiety in the elevated plus maze and social avoidance of an unfamiliar male mouse. A direct measured effect of the stressfulness of the living environment, i.e. the amount of daily aggression received, predicted the degree of corticosterone level and locomotor activity but not of the other parameters. This is the first study validating a chronic subordination stress paradigm in 129SvEv male mice. Results demonstrated remarkable stress vulnerability and establish the validity to use this mouse strain as a model for depression-like disorders. PMID:21093519

  10. Long-range antigravity

    Energy Technology Data Exchange (ETDEWEB)

    Macrae, K.I.; Riegert, R.J. (Maryland Univ., College Park (USA). Center for Theoretical Physics)

    1984-10-01

    We consider a theory in which fermionic matter interacts via long-range scalar, vector and tensor fields. In order not to be in conflict with experiment, the scalar and vector couplings for a given fermion must be equal, as is natural in a dimensionally reduced model. Assuming that the Sun is not approximately neutral with respect to these new scalar-vector charges, and if the couplings saturate the experimental bounds, then their strength can be comparable to that of gravity. Scalar-vector fields of this strength can compensate for a solar quadrupole moment contribution to Mercury's anomalous perihelion precession.

  11. 4584例手足口病EV71病毒感染情况分析%Analysis on infection status of enterovirus EV71 for 4 584 cases children of hand foot and mouth disease

    Institute of Scientific and Technical Information of China (English)

    2016-01-01

    目的 回顾性分析2009年至2013年第四军医大学西京医院手足口病肠道病毒71型(EV71)的感染情况.方法 采用实时荧光定量PCR的方法检测手足口病患儿的咽拭子或疱液标本.结果 2009年至2013年我院共收治手足口病患儿4 584例,其中EV71阳性标本369例,各年EV71的感染率依次分别为7.84%、5.77%、16.71%、10.16%、3.66%.不同年份EV71感染率差异有显著性(P<0.05).≤3岁的婴幼儿EV71感染率最高(65.58%),每年4~7月手足口病感染人数明显升高.结论 手足口病EV71型各年感染率不同,有明显的季节及人群分布.在流行季节应当加强宣传培训及督导作用,采取安全措施,有效控制病情.

  12. Characteristics and treatment strategies of severe enterovirus 71 (EV71) infection in children%小儿危重肠病毒71型(EV71)感染临床特征及救治策略

    Institute of Scientific and Technical Information of China (English)

    张育才; 徐梁; 戎群芳

    2010-01-01

    @@ 肠病毒71型(Enterovirus 71,EV71)是手足口病病原之一,也是发生危重病例最重要的病原.根据中国卫生部及疾病预防和控制中心资料,绝大多数死亡病例是由E71感染所致.重症EV71感染主要表现为脑干脑炎、脑脊髓炎、脊髓灰质炎样综合征等.

  13. Primary Cosmic Rays with Energies above 1015 eV - Rapporteur Review of Poster Presentations at the 23rd ECRS - Session PCR 2

    Science.gov (United States)

    Szabelski, Jacek

    2013-02-01

    Measurements of atmospheric Extensive Air Showers (EAS) are the only way of experimental studies of Primary Cosmic Rays (CR) with energies above 1015 eV. The final targets of these studies are search for astrophysical origin of these particles and properties of particle production in high energy particle interaction. Works presented at the PCR 2 session in the form of posters reflected the current progress in this area. In this review presented posters were grouped according to CR energy range, astrophysical significance, relation to high energy physics interaction properties and interaction models, and future experiments. 42 posters were submitted for this session. Some of the presented material in posters overlapped in parts with oral presentations.

  14. Synthesis and properties of layered synthetic microstructure (LSM) dispersion elements for 62 eV (200A) to 1. 24 keV (10A) radiation. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Barbee, T.W. Jr.

    1981-08-01

    The opportunities offered by engineered synthetic multilayer dispersion elements for x-rays have been recognized since the earliest days of x-ray diffraction analysis. In this paper, application of sputter deposition technology to the synthesis of Layered Synthetic Microstructure (LSMs) of sufficient quality for use as x-ray dispersion elements is discussed. It will be shown that high efficiency, controllable bandwidth dispersion elements, with d spacings varying from 15 A to 180 A, may be synthesized onto both mechanically stiff and flexible substrates. Multilayer component materials include tungsten, niobium, molybdenum, titanium, vanadium, and silicon layers separated by carbon layers. Experimental observations of peak reflectivity in first order, integrated reflectivity in first order, and diffraction performance at selected photon energies in the range, 100 to 15,000 eV, will be reported and compared to theory.

  15. Six-step Voltage Control of PM Brushless AC Motors under High Speed Flux-weakening Operation for EV/HEV Applications

    Institute of Scientific and Technical Information of China (English)

    诸自强

    2008-01-01

    The torque-speed characteristics of brushless motor having an interior permanent magnet rotor and a sinusoidalback-emf waveform are compared experimentally when it is operated in brushless AC (BLAC) mode and brushless DC(BLDC) modes with both 2-phase, 120° conduction (BLDC-120) and 3-phase,180° conduction (BLDC-180).Particularemphasis is on high-speed,six-step voltage controlled,flux-weakening operation.h is shown that for EV/HEV applications,even for interior PM brushless motors which have sinusoidal back-emf waveforms,in order to achieve maximum torque perampere capability over wide operation speed range,it is advantageous to employ a hybrid operation mode-BLAC operationin the constant torque region and six-step voltage control (BLDC-180 operation, together with current phase control) inthe flux-weakening region.

  16. Primary Cosmic Rays with Energies above 1015 eV – Rapporteur Review of Poster Presentations at the 23rd ECRS – Session PCR 2

    International Nuclear Information System (INIS)

    Measurements of atmospheric Extensive Air Showers (EAS) are the only way of experimental studies of Primary Cosmic Rays (CR) with energies above 1015 eV. The final targets of these studies are search for astrophysical origin of these particles and properties of particle production in high energy particle interaction. Works presented at the PCR 2 session in the form of posters reflected the current progress in this area. In this review presented posters were grouped according to CR energy range, astrophysical significance, relation to high energy physics interaction properties and interaction models, and future experiments. 42 posters were submitted for this session. Some of the presented material in posters overlapped in parts with oral presentations.

  17. Monocular visual ranging

    Science.gov (United States)

    Witus, Gary; Hunt, Shawn

    2008-04-01

    The vision system of a mobile robot for checkpoint and perimeter security inspection performs multiple functions: providing surveillance video, providing high resolution still images, and providing video for semi-autonomous visual navigation. Mid-priced commercial digital cameras support the primary inspection functions. Semi-autonomous visual navigation is a tertiary function whose purpose is to reduce the burden of teleoperation and free the security personnel for their primary functions. Approaches to robot visual navigation require some form of depth perception for speed control to prevent the robot from colliding with objects. In this paper present the initial results of an exploration of the capabilities and limitations of using a single monocular commercial digital camera for depth perception. Our approach combines complementary methods in alternating stationary and moving behaviors. When the platform is stationary, it computes a range image from differential blur in the image stack collected at multiple focus settings. When the robot is moving, it extracts an estimate of range from the camera auto-focus function, and combines this with an estimate derived from angular expansion of a constellation of visual tracking points.

  18. Observation of the suppression of the flux of cosmic rays above 4 x 10 (19) eV.

    Science.gov (United States)

    Abraham, J; Abreu, P; Aglietta, M; Aguirre, C; Allard, D; Allekotte, I; Allen, J; Allison, P; Alvarez-Muñiz, J; Ambrosio, M; Anchordoqui, L; Andringa, S; Anzalone, A; Aramo, C; Argirò, S; Arisaka, K; Armengaud, E; Arneodo, F; Arqueros, F; Asch, T; Asorey, H; Assis, P; Atulugama, B S; Aublin, J; Ave, M; Avila, G; Bäcker, T; Badagnani, D; Barbosa, A F; Barnhill, D; Barroso, S L C; Baughman, B; Bauleo, P; Beatty, J J; Beau, T; Becker, B R; Becker, K H; Bellido, J A; Benzvi, S; Berat, C; Bergmann, T; Bernardini, P; Bertou, X; Biermann, P L; Billoir, P; Blanch-Bigas, O; Blanco, F; Blasi, P; Bleve, C; Blümer, H; Bohácová, M; Bonifazi, C; Bonino, R; Brack, J; Brogueira, P; Brown, W C; Buchholz, P; Bueno, A; Burton, R E; Busca, N G; Caballero-Mora, K S; Cai, B; Camin, D V; Caramete, L; Caruso, R; Carvalho, W; Castellina, A; Catalano, O; Cataldi, G; Cazon, L; Cester, R; Chauvin, J; Chiavassa, A; Chinellato, J A; Chou, A; Chudoba, J; Chye, J; Clark, P D J; Clay, R W; Colombo, E; Conceição, R; Connolly, B; Contreras, F; Coppens, J; Cordier, A; Cotti, U; Coutu, S; Covault, C E; Creusot, A; Criss, A; Cronin, J; Curutiu, A; Dagoret-Campagne, S; Daumiller, K; Dawson, B R; de Almeida, R M; De Donato, C; de Jong, S J; De La Vega, G; Junior, W J M de Mello; Neto, J R T de Mello; De Mitri, I; de Souza, V; Del Peral, L; Deligny, O; Della Selva, A; Fratte, C Delle; Dembinski, H; Di Giulio, C; Diaz, J C; Diep, P N; Dobrigkeit, C; D'Olivo, J C; Dong, P N; Dornic, D; Dorofeev, A; Dos Anjos, J C; Dova, M T; D'Urso, D; Dutan, I; Duvernois, M A; Engel, R; Epele, L; Erdmann, M; Escobar, C O; Etchegoyen, A; Luis, P Facal San; Falcke, H; Farrar, G; Fauth, A C; Fazzini, N; Ferrer, F; Ferrero, A; Fick, B; Filevich, A; Filipcic, A; Fleck, I; Fracchiolla, C E; Fulgione, W; García, B; Gámez, D García; Garcia-Pinto, D; Garrido, X; Geenen, H; Gelmini, G; Gemmeke, H; Ghia, P L; Giller, M; Glass, H; Gold, M S; Golup, G; Albarracin, F Gomez; Berisso, M Gómez; Gonçalves, P; do Amaral, M Gonçalves; Gonzalez, D; Gonzalez, J G; González, M; Góra, D; Gorgi, A; Gouffon, P; Grassi, V; Grillo, A F; Grunfeld, C; Guardincerri, Y; Guarino, F; Guedes, G P; Gutiérrez, J; Hague, J D; Halenka, V; Hamilton, J C; Hansen, P; Harari, D; Harmsma, S; Harton, J L; Haungs, A; Hauschildt, T; Healy, M D; Hebbeker, T; Hebrero, G; Heck, D; Hojvat, C; Holmes, V C; Homola, P; Hörandel, J R; Horneffer, A; Hrabovský, M; Huege, T; Hussain, M; Iarlori, M; Insolia, A; Ionita, F; Italiano, A; Kaducak, M; Kampert, K H; Karova, T; Kasper, P; Kégl, B; Keilhauer, B; Kemp, E; Kieckhafer, R M; Klages, H O; Kleifges, M; Kleinfeller, J; Knapik, R; Knapp, J; Koang, D-H; Krieger, A; Krömer, O; Kuempel, D; Kunka, N; Kusenko, A; La Rosa, G; Lachaud, C; Lago, B L; Lebrun, D; Lebrun, P; Lee, J; de Oliveira, M A Leigui; Letessier-Selvon, A; Leuthold, M; Lhenry-Yvon, I; López, R; Agüera, A Lopez; Bahilo, J Lozano; Lucero, A; García, R Luna; Maccarone, M C; Macolino, C; Maldera, S; Mancarella, G; Manceñido, M E; Mandat, D; Mantsch, P; Mariazzi, A G; Maris, I C; Falcon, H R Marquez; Martello, D; Martínez, J; Bravo, O Martínez; Mathes, H J; Matthews, J; Matthews, J A J; Matthiae, G; Maurizio, D; Mazur, P O; McCauley, T; McEwen, M; McNeil, R R; Medina, M C; Medina-Tanco, G; Melo, D; Menichetti, E; Menschikov, A; Meurer, C; Meyhandan, R; Micheletti, M I; Miele, G; Miller, W; Mollerach, S; Monasor, M; Ragaigne, D Monnier; Montanet, F; Morales, B; Morello, C; Moreno, J C; Morris, C; Mostafá, M; Muller, M A; Mussa, R; Navarra, G; Navarro, J L; Navas, S; Necesal, P; Nellen, L; Newman-Holmes, C; Newton, D; Nhung, P T; Nierstenhoefer, N; Nitz, D; Nosek, D; Nozka, L; Oehlschläger, J; Ohnuki, T; Olinto, A; Olmos-Gilbaja, V M; Ortiz, M; Ortolani, F; Ostapchenko, S; Otero, L; Pacheco, N; Selmi-Dei, D Pakk; Palatka, M; Pallotta, J; Parente, G; Parizot, E; Parlati, S; Pastor, S; Patel, M; Paul, T; Pavlidou, V; Payet, K; Pech, M; Pekala, J; Pelayo, R; Pepe, I M; Perrone, L; Pesce, R; Petrera, S; Petrinca, P; Petrov, Y; Pichel, A; Piegaia, R; Pierog, T; Pimenta, M; Pinto, T; Pirronello, V; Pisanti, O; Platino, M; Pochon, J; Privitera, P; Prouza, M; Quel, E J; Rautenberg, J; Redondo, A; Reucroft, S; Revenu, B; Rezende, F A S; Ridky, J; Riggi, S; Risse, M; Rivière, C; Rizi, V; Roberts, M; Robledo, C; Rodriguez, G; Martino, J Rodriguez; Rojo, J Rodriguez; Rodriguez-Cabo, I; Rodríguez-Frías, M D; Ros, G; Rosado, J; Roth, M; Rouillé-d'Orfeuil, B; Roulet, E; Rovero, A C; Salamida, F; Salazar, H; Salina, G; Sánchez, F; Santander, M; Santo, C E; Santos, E M; Sarazin, F; Sarkar, S; Sato, R; Scherini, V; Schieler, H; Schmidt, A; Schmidt, F; Schmidt, T; Scholten, O; Schovánek, P; Schroeder, F; Schulte, S; Schüssler, F; Sciutto, S J; Scuderi, M; Segreto, A; Semikoz, D; Settimo, M; Shellard, R C; Sidelnik, I; Siffert, B B; Sigl, G

    2008-08-01

    The energy spectrum of cosmic rays above 2.5 x 10;{18} eV, derived from 20,000 events recorded at the Pierre Auger Observatory, is described. The spectral index gamma of the particle flux, J proportional, variantE;{-gamma}, at energies between 4 x 10;{18} eV and 4 x 10;{19} eV is 2.69+/-0.02(stat)+/-0.06(syst), steepening to 4.2+/-0.4(stat)+/-0.06(syst) at higher energies. The hypothesis of a single power law is rejected with a significance greater than 6 standard deviations. The data are consistent with the prediction by Greisen and by Zatsepin and Kuz'min. PMID:18764444

  19. Properties of the 4.45 eV optical absorption band in LiF:Mg, Ti

    International Nuclear Information System (INIS)

    The optical absorption (OA) and thermoluminescence (TL) of dosimetric LiF:Mg,Ti (TLD-100) as well as nominally pure LiF single crystal have been studied as a function of irradiation dose, thermal and optical bleaching in order to investigate the role of the 4.45 eV OA band in low temperature TL. Computerised deconvolution was used to resolve the absorption spectrum into individual gaussian bands and the TL glow curve into glow peaks. Although the 4.45 eV OA band shows thermal decay characteristics similar to the 4.0 eV band its dose filling constant and optical bleaching properties suggest that it cannot be associated with the TL of composite peaks 4 or 5. Its presence in optical grade single crystal LiF further suggests that it is an intrinsic defect or possibly associated with chance impurities other than Mg, Ti. (authors)

  20. 重症EV71感染手足口病患儿的护理现状

    Institute of Scientific and Technical Information of China (English)

    巫玉峰

    2016-01-01

    从心理护理、消毒隔离、皮肤护理、口腔及饮食护理、高热的护理、病情观察及健康宣教方面对重症EV71感染手足口病患儿的护理现状进行了综述,说明加强医护人员的对重症EV71感染手足口病的护理,对于重症EV71感染手足口病患儿的治疗及危重患者的救治十分重要。