WorldWideScience

Sample records for 116th ncab min

  1. OnlineMin

    DEFF Research Database (Denmark)

    Brodal, Gerth Stølting; Moruz, Gabriel; Negoescu, Andrei

    2015-01-01

    In the field of online algorithms paging is one of the most studied problems. For randomized paging algorithms a tight bound of Hk on the competitive ratio has been known for decades, yet existing algorithms matching this bound have high running times. We present a new randomized paging algorithm...... OnlineMin that has optimal competitiveness and allows fast implementations. In fact, if k pages fit in internal memory the best previous solution required O(k2) time per request and O(k) space. We present two implementations of OnlineMin which use O(k) space, but only O(logk) worst case time and O......(logk/loglogk) worst case time per page request respectively...

  2. Se min kjole

    DEFF Research Database (Denmark)

    Bogen Se min kjole udkom i anledning af 50-året for de første ordinationer af kvindelige præster i den danske folkekirke i 1948. Bogen giver analyser af, hvad kvindelige præster har betydet for præsterollen og for prædikengenren; den fortæller om de første kvindelige præsters liv og syn på...

  3. MInOSS project

    Science.gov (United States)

    Sartori, Alvise; Gottardi, M.; Lee, P.; Maloberti, F.; O'Leary, Paul; Simoni, A.; Torelli, Guido

    1996-12-01

    The main goal of the ESPRIT project 'microintegrated intelligent optical sensor systems' (MInOSS) was to investigate a design methodology for optical sensor systems. The methodology was applied to the design of a library of modules and general building blocks in a standard CMOS technology aimed at easing the design of future optical sensors. A set of demonstrators was developed, including a linear array of sensors for spectrophotometry and a number of 2D sensor arrays for use in 'intelligent' digital cameras. The main results of the project to be reviewed in this paper include a library photodiode arrays and charge amplifiers; three-step flash and algorithmic analog-to- digital converters for on-chip conversion; the architectures of the linear and 2D intelligent sensors which were developed; and guidelines for the practical design of photosensors and pixel arrays in a mixed analogue/digital/optical environment.

  4. 改进的 Min-Min 算法研究%Research on Improved Min-Min Algorithm

    Institute of Scientific and Technical Information of China (English)

    邓树强; 刘波; 庞雄文

    2011-01-01

    Task scheduling is an important part of grid system, and the task scheduling algorithm is the most important in the task scheduling. After the research of Min-Min algorithm, this paper points out the shortcomings of Min-Min algorithm. With the goal of grid task scheduling, several improved Min-Min algorithms are drawn out in optimal scheduling, load balancing, quality of service and the charge. Then this paper introduces the advantages and disadvantages of the improved algorithms. It provides some reference to improve the algorithms in the future.%任务调度是网格系统中重要的一环,而任务的调度算法更显得是重中之重.本文对Min-Min算法进行分析,指出Min-Min算法存在的不足.结合网格任务调度的目标,分别从最优调度、负我均衡、服务质量、价格费用4方面提出几种改进的Min-Min算法,重点介绍算法思路,指出算法的优缺点,为以后的改进工作提供参考.

  5. Instant MinGW starter

    CERN Document Server

    Shpigor, Ilya

    2013-01-01

    This is a Starter guide designed to enable the reader to start using MinGW to develop Microsoft Windows applications as quickly, and as efficiently, as possible. This book is for C and C++ developers who are looking for new and effective instruments to use in application development for Microsoft Windows. No experience of MinGW is needed: this book will guide you through the essentials to get you using the software like a pro in a matter of hours.

  6. USGS 1-min Dst index

    Science.gov (United States)

    Gannon, J.L.; Love, J.J.

    2011-01-01

    We produce a 1-min time resolution storm-time disturbance index, the USGS Dst, called Dst8507-4SM. This index is based on minute resolution horizontal magnetic field intensity from low-latitude observatories in Honolulu, Kakioka, San Juan and Hermanus, for the years 1985-2007. The method used to produce the index uses a combination of time- and frequency-domain techniques, which more clearly identifies and excises solar-quiet variation from the horizontal intensity time series of an individual station than the strictly time-domain method used in the Kyoto Dst index. The USGS 1-min Dst is compared against the Kyoto Dst, Kyoto Sym-H, and the USGS 1-h Dst (Dst5807-4SH). In a time series comparison, Sym-H is found to produce more extreme values during both sudden impulses and main phase maximum deviation, possibly due to the latitude of its contributing observatories. Both Kyoto indices are shown to have a peak in their distributions below zero, while the USGS indices have a peak near zero. The USGS 1-min Dst is shown to have the higher time resolution benefits of Sym-H, while using the more typical low-latitude observatories of Kyoto Dst. ?? 2010.

  7. Self-organization of the MinE ring in subcellular Min oscillations

    OpenAIRE

    Derr, Julien; Hopper, Jason T.; Sain, Anirban; Rutenberg, Andrew D.

    2009-01-01

    We model the self-organization of the MinE ring that is observed during subcellular oscillations of the proteins MinD and MinE within the rod-shaped bacterium {\\it Escherichia coli}. With a steady-state approximation, we can study the MinE-ring generically -- apart from the other details of the Min oscillation. Rebinding of MinE to depolymerizing MinD filament tips controls MinE ring formation through a scaled cell shape parameter $\\tilde{r}$. We find two types of E-ring profiles near the fil...

  8. Min-protein oscillations in round bacteria

    Science.gov (United States)

    Huang, Kerwyn Casey; Wingreen, Ned S.

    2004-12-01

    In rod-shaped Escherichia coli cells, the Min proteins, which are involved in division-site selection, oscillate from pole-to-pole. The homologs of the Min proteins from the round bacterium Neisseria gonorrhoeae also form a spatial oscillator when expressed in wild-type and round, rodA- mutants of E. coli, suggesting that the Min proteins form an oscillator in N. gonorrhoeae. Here we report that a numerical model for Min-protein oscillations in rod-shaped cells also produces oscillations in round cells (cocci). Our numerical results explain why the MinE-protein rings found in wild-type E. coli are absent in round mutants. In addition, we find that for round cells there is a minimum radius below which oscillations do not occur, and a maximum radius above which oscillations become mislocalized. Finally, we demonstrate that Min-protein oscillations can select the long axis in nearly round cells based solely on geometry, a potentially important factor in division-plane selection in cocci.

  9. 30-min x 30-min Terrestrial Mean Free-Air Anomalies

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The 30-min x 30-min Terrestrial Mean Free-Air Gravity Anomaly and Geoid Undulations Data Base was compiled and developed by the Ohio State University. This data...

  10. Quantum Max-flow/Min-cut

    Science.gov (United States)

    Cui, Shawn X.; Freedman, Michael H.; Sattath, Or; Stong, Richard; Minton, Greg

    2016-06-01

    The classical max-flow min-cut theorem describes transport through certain idealized classical networks. We consider the quantum analog for tensor networks. By associating an integral capacity to each edge and a tensor to each vertex in a flow network, we can also interpret it as a tensor network and, more specifically, as a linear map from the input space to the output space. The quantum max-flow is defined to be the maximal rank of this linear map over all choices of tensors. The quantum min-cut is defined to be the minimum product of the capacities of edges over all cuts of the tensor network. We show that unlike the classical case, the quantum max-flow=min-cut conjecture is not true in general. Under certain conditions, e.g., when the capacity on each edge is some power of a fixed integer, the quantum max-flow is proved to equal the quantum min-cut. However, concrete examples are also provided where the equality does not hold. We also found connections of quantum max-flow/min-cut with entropy of entanglement and the quantum satisfiability problem. We speculate that the phenomena revealed may be of interest both in spin systems in condensed matter and in quantum gravity.

  11. Learnability of min-max pattern classifiers

    Science.gov (United States)

    Yang, Ping-Fai; Maragos, Petros

    1991-11-01

    This paper introduces the class of thresholded min-max functions and studies their learning under the probably approximately correct (PAC) model introduced by Valiant. These functions can be used as pattern classifiers of both real-valued and binary-valued feature vectors. They are a lattice-theoretic generalization of Boolean functions and are also related to three-layer perceptrons and morphological signal operators. Several subclasses of the thresholded min- max functions are shown to be learnable under the PAC model.

  12. Dynamic assembly of MinD on phospholipid vesicles regulated by ATP and MinE

    OpenAIRE

    Hu, Zonglin; Gogol, Edward P.; Lutkenhaus, Joe

    2002-01-01

    Selection of the division site in Escherichia coli is regulated by the min system and requires the rapid oscillation of MinD between the two halves of the cell under the control of MinE. In this study we have further investigated the molecular basis for this oscillation by examining the interaction of MinD with phospholipid vesicles. We found that MinD bound to phospholipid vesicles in the presence of ATP and, upon binding, assembled into a well-ordered helical array that deformed the vesicle...

  13. min kilpailukyky Saksan markkinoilla

    OpenAIRE

    Hakala, Johanna

    2007-01-01

    Tutkimuksessa selvitettiin Pohjois-Satakunnassa Jämijärvellä sijaitsevan Jämin kilpailukyky matkailukohteena Saksan markkinoilla, eritoten Baijerin alueella, verrattuna Pohjois-Suomen viiteen suureen matkailukohteeseen Levi, Ylläs, Pyhä-Luosto, Ruka ja Vuokatti. Tutkimus loi katsauksen matkailualaan ja sen tulevaisuuden kehitykseen. Tutkimus ei käsitellyt pohjoisen lomakohteita yleisesti totuttuina laskettelukeskuksina, vaan ympärivuotisina lomakohteina ja keskittyi vertailussa kohteiden koko...

  14. 60wrd/min art critic

    OpenAIRE

    Waxman, Lori

    2015-01-01

    Tiré du site Internet de Onestar Press: "The following was announced on the windows of a small blue house at dOCUMENTA (13) : The “60 wrd/min art critic” is available. ­Reviews are free of charge, and are written here on Mondays, Wednesdays and Saturdays ­between the hours of 1 and 6 p.m. Lori Waxman will spend 25 minutes ­looking at submitted work and writing a 200-word review. Thoughtful responses are guaranteed. Completed reviews will be ­published in the Hessische/­Niedersächsische­Allgem...

  15. 15. 7-min periodicity in OJ287

    Energy Technology Data Exchange (ETDEWEB)

    Valtaoja, E.; Lehto, H.; Teerikorpi, P.; Korhonen, T.; Valtonen, M.; Teraesranta, H.; Salonen, E.; Urpo, S.; Tiuri, M.; Piirola, V.; Saslaw, W.C.

    1985-03-14

    The BL Lac-type object OJ287, with a redshift z = 0.306 and a luminosity exceeding 10/sup 47/ erg s/sup -1/ at maximum light, is among the brightest and most violently variable objects of its class. Rapid variations, with timescales of a few hours or less, have been reported over a wide range of wavelengths and also in polarization, imposing strong constraints on the size and dynamics of the source. The detection of periodic variations in OJ287, or in any other compact extragalactic source, would be even more important, as these could be related to rotation or orbital motion in the source. So far the only searches sensitive to periodic variations shorter than 1 h are the photometric observations of Visvanathan and Elliot, Frohlich et al. and Kiplinger, in which a 40-min period in OJ287 was respectively found, confirmed and not detected. Here the detection of a 15.7-min periodic flux variation in OJ287 in April 1981 at 37 GHz is reported. The source has been subsequently monitored for 265 h at 22 and 37 GHz, as well as in optical photometry, and the same period has been seen in simultaneous observations. The peak-peak amplitude of the variation is 1-10% of the total intensity. Other periods may also exist. 17 references, 3 figures.

  16. Min-Max Spaces and Complexity Reduction in Min-Max Expansions

    Energy Technology Data Exchange (ETDEWEB)

    Gaubert, Stephane, E-mail: Stephane.Gaubert@inria.fr [Ecole Polytechnique, INRIA and CMAP (France); McEneaney, William M., E-mail: wmceneaney@ucsd.edu [University of California San Diego, Dept. of Mech. and Aero. Eng. (United States)

    2012-06-15

    Idempotent methods have been found to be extremely helpful in the numerical solution of certain classes of nonlinear control problems. In those methods, one uses the fact that the value function lies in the space of semiconvex functions (in the case of maximizing controllers), and approximates this value using a truncated max-plus basis expansion. In some classes, the value function is actually convex, and then one specifically approximates with suprema (i.e., max-plus sums) of affine functions. Note that the space of convex functions is a max-plus linear space, or moduloid. In extending those concepts to game problems, one finds a different function space, and different algebra, to be appropriate. Here we consider functions which may be represented using infima (i.e., min-max sums) of max-plus affine functions. It is natural to refer to the class of functions so represented as the min-max linear space (or moduloid) of max-plus hypo-convex functions. We examine this space, the associated notion of duality and min-max basis expansions. In using these methods for solution of control problems, and now games, a critical step is complexity-reduction. In particular, one needs to find reduced-complexity expansions which approximate the function as well as possible. We obtain a solution to this complexity-reduction problem in the case of min-max expansions.

  17. OPT-Min-Min:基于Min-Min网格资源调度算法的优化%OPT-Min-Min:the Grid Resources Scheduling Algorithm Based on Load Balance

    Institute of Scientific and Technical Information of China (English)

    张忠平; 温利娟

    2014-01-01

    网格是由大量地理上分布的异构资源组成的高性能并行计算系统,网格资源调度算法在网格资源管理中具有重要意义.在众多的启发式调度算法中,Min-Min调度算法取得了良好的调度结果,但是Min-Min调度算法导致负载不平衡.本文针对Min-Min调度算法存在负载不均,采用重负载资源的任务分配给轻负载资源执行来均衡负载的策略,提出OPT-Min-Min算法,提高资源利用率,达到较小的完成时间;最后采用Braun等人提出的仿真模型基准来验证算法有效性.

  18. Dynamic assembly of MinD into filament bundles modulated by ATP, phospholipids, and MinE

    OpenAIRE

    Suefuji, Kyoko; Valluzzi, Regina; RayChaudhuri, Debabrata

    2002-01-01

    Accurate positioning of the division septum at the equator of Escherichia coli cells requires a rapid oscillation of MinD ATPase between the polar halves of the cell membrane, together with the division inhibitor MinC, under MinE control. The mechanism underlying MinD oscillation remains poorly understood. Here, we demonstrate that purified MinD assembles into protein filaments in the presence of ATP. Incubation with phospholipid vesicles further stimulates MinD polymerization. Addition of pu...

  19. Minä mediatanssija? : erikoiskoulutusluokkalaisten tanssi-ihanteet ja minäkuva tanssitaiteen perusopetuksessa

    OpenAIRE

    Lähteenmäki, Carita

    2011-01-01

    Tämä kirjallinen tutkielma on osa Turun ammattikorkeakoulun tanssinopettajan (AMK) tutkintoon sisältyvää opinnäytetyökokonaisuutta. Taiteellinen osa opinnäytetyöstä on koreografia Lähelle lausuttua. Kirjallinen osa on tutkielma tanssia erikoiskoulutusluokalla harrastavien nuorten ihanteista, minäkuvasta ja mediakäyttäytymisestä. Aineistona käytetään teoreettista tietoa mediapsykologiasta, 35 tanssinoppilaan kyselylomakevastaukset sekä kolmen tanssinopettajaopiskelijan sähköpostikysely ja yhde...

  20. QoS Guided Min-Min Heuristic for Grid Task Scheduling

    Institute of Scientific and Technical Information of China (English)

    HE XiaoShan(何晓珊); SUN XianHe(孙贤和); Gregor von Laszewski

    2003-01-01

    Task scheduling is an integrated component of computing. With the emergence of Grid and ubiquitous computing, new challenges appear in task scheduling based on properties such as security, quality of service, and lack of central control within distributed administrative domains. A Grid task scheduling framework must be able to deal with these issues. One of the goals of Grid task scheduling is to achieve high system throughput while matching applications with the available computing resources. This matching of resources in a non-deterministically shared heterogeneous environment leads to concerns over Quality of Service (QoS). In this paper a novel QoS guided task scheduling algorithm for Grid computing is introduced. The proposed novel algorithm is based on a general adaptive scheduling heuristics that includes QoS guidance.The algorithm is evaluated within a simulated Grid environment. The experimental results show that the new QoS guided Min-Min heuristic can lead to significant performance gain for a variety of applications. The approach is compared with others based on the quality of the prediction formulated by inaccurate information.

  1. Multiphase Scalable Grid Scheduler Based on Multi-QoS Using Min-Min Heuristic

    Directory of Open Access Journals (Sweden)

    Shamala A/P K

    2010-09-01

    Full Text Available Abstract—In scheduling, the main factor that affects searchingspeed and mapping performance is the number of resources orthe size of search space. In grid computing, the schedulerperformance plays an essential role in the overall performance.So, it is obvious the need for scalable scheduler that can managethe growing in resources (i.e. scalable. With the assumption thateach resource has its own specifications and each job has its ownrequirements; then searching the whole search space (all theresources can waste plenty of scheduling time. In this paper, wepropose a two-phase scheduler that uses min-min algorithm tospeed up the mapping time with almost the same efficiency. Thescheduler is also based on the assumption that the resources ingrid computing can be classified into clusters. The scheduler triesfirst to schedule the jobs to the suitable cluster (i.e. first phaseand then each cluster schedule the incoming jobs to the suitableresources (i.e. second phase. The scheduler is based onmultidimensional QoS to enhance the mapping as much as it can.The simulation results show that the use of two-phase strategycan support the scalable scheduler.

  2. Research on Min-Min Scheduling Algorithm and Improved Algorithm in Grid%Min-Min调度算法及改进在网格中的研究

    Institute of Scientific and Technical Information of China (English)

    严华; 周永刚; 蔡瑞英

    2009-01-01

    网格是一门新兴技术.首先介绍了经典的Min-Min调度算法,然后考虑网络环境对QoS的要求,对Min-Min调度算法进行改进,最后用SimGrid对Min-Min调度算法及提出的改进算法进行仿真,比较了两个算法的性能.

  3. Improved Min-Min scheduling algorithm based on QoS%基于QoS的改进Min-Min调度算法

    Institute of Scientific and Technical Information of China (English)

    林志杰; 张友斌; 顾静

    2015-01-01

    The classical Min-Min scheduling algorithm exists the problems of load unbalance, the low resource utilization rate and long processing time. To solve these problems, a scheduling algorithm named P-Min is proposed, which is based on task priority and combined greedy scheduling strategy to schedule. Experimental results show that, as compared with the Min-Min algorithm, the P-Min Algorithm improves 18% in load balance and 8.03% in the overall task execution time, respectively.%针对经典 Min–Min 调度算法存在负载不均,资源利用率低,处理时间长等问题,提出了 P–Min 算法。该算法根据任务的优先级并结合贪心算法来实现调度。仿真结果表明: P–Min算法在负载均衡的资源利用率方面较Min–Min算法提高了17%,任务总体执行时间调高了8.03%。

  4. Minä teen majani yrttitarhaan (3/4 C)

    OpenAIRE

    2011-01-01

    Laulun sanat: Minä teen majani yrttitarhaan, jossa linnut laulaa saamull' varhain. En mä tee sitä itselleni, vaan sille jota minä rakastan. En mä tee sitä itselleni, vaan sille jota minä rakastan!

  5. MinFinder v2.0: An improved version of MinFinder

    Science.gov (United States)

    Tsoulos, Ioannis G.; Lagaris, Isaac E.

    2008-10-01

    A new version of the "MinFinder" program is presented that offers an augmented linking procedure for Fortran-77 subprograms, two additional stopping rules and a new start-point rejection mechanism that saves a significant portion of gradient and function evaluations. The method is applied on a set of standard test functions and the results are reported. New version program summaryProgram title: MinFinder v2.0 Catalogue identifier: ADWU_v2_0 Program summary URL:http://cpc.cs.qub.ac.uk/summaries/ADWU_v2_0.html Program obtainable from: CPC Program Library, Queen's University, Belfast, N. Ireland Licensing provisions: Standard CPC Licence, http://cpc.cs.qub.ac.uk/licence/licence.html No. of lines in distributed program, including test data, etc.: 14 150 No. of bytes in distributed program, including test data, etc.: 218 144 Distribution format: tar.gz Programming language used: GNU C++, GNU FORTRAN, GNU C Computer: The program is designed to be portable in all systems running the GNU C++ compiler Operating system: Linux, Solaris, FreeBSD RAM: 200 000 bytes Classification: 4.9 Catalogue identifier of previous version: ADWU_v1_0 Journal reference of previous version: Computer Physics Communications 174 (2006) 166-179 Does the new version supersede the previous version?: Yes Nature of problem: A multitude of problems in science and engineering are often reduced to minimizing a function of many variables. There are instances that a local optimum does not correspond to the desired physical solution and hence the search for a better solution is required. Local optimization techniques can be trapped in any local minimum. Global optimization is then the appropriate tool. For example, solving a non-linear system of equations via optimization, one may encounter many local minima that do not correspond to solutions, i.e. they are far from zero. Solution method: Using a uniform pdf, points are sampled from a rectangular domain. A clustering technique, based on a typical distance

  6. Automatic generation of min-weighted persistent formations

    Institute of Scientific and Technical Information of China (English)

    Luo Xiao-Yuan; Li Shao-Bao; Guan Xin-Ping

    2009-01-01

    This paper researched into some methods for generating min-weighted rigid graphs and min-weighted persistent graphs.Rigidity and persistence are currently used in various studies on coordination and control of autonomous multi-agent formations.To minimize the communication complexity of formations and reduce energy consumption,this paper introduces the rigidity matrix and presents three algorithms for generating min-weighted rigid and min weighted persistent graphs.First,the existence of a min-weighted rigid graph is proved by using the rigidity matrix,and algorithm 1 is presented to generate the min-weighted rigid graphs.Second,the algorithm 2 based on the rigidity matrix is presented to direct the edges of min-weighted rigid graphs to generate min-weighted persistent graphs.Third,the formations with range constraints are considered,and algorithm 3 is presented to find whether a framework can form a min-weighted persistent formation.Finally,some simulations are given to show the efficiency of our research.

  7. Task scheduling based on Min-Min genetic algorithm in grid%基于Min-Min遗传算法的网格任务调度方法

    Institute of Scientific and Technical Information of China (English)

    马景奕; 隋兵; 舒万能

    2008-01-01

    针对网格环境异构、分布等特点,在现有的任务调度算法的基础上,结合Min-Min算法和遗传算法的优点,提出了一种基于Min-Min遗传算法的任务调度方法.仿真实验表明:在网格环境下,该算法具有合理性和高效性.

  8. Research and improvement of Min-Min scheduling algorithm%Min-Min调度算法的研究与改进

    Institute of Scientific and Technical Information of China (English)

    杜玉霞; 刘方爱; 郭磊

    2010-01-01

    在动态、异构的网格环境中,任务调度是复杂并且极具挑战性的一个问题.在分析任务调度算法的基础上,着重研究了经典的Min-Min调度算法,分析了Min-Min调度算法的缺陷,即负载不均衡,并且不能从经济的角度来实现调度.针对负载均衡和经济这两方面来对Min-Min调度算法进行改进,提出了基于价格改进的Min-Min调度算法,分析表明,改进后的算法在一定程度上平衡了负载,并且节省了一部分费用,说明了算法的可行性.

  9. Projekti Min-E-Max kohtumine Saksamaal / Katrin Arge

    Index Scriptorium Estoniae

    Arge, Katrin

    2005-01-01

    Oktoobri keskel toimus Lõuna-Saksamaa väikelinnas Oberderdingenis Hispaania, Portugali, Ungari, Leedu, Eesti ja Saksamaa õpetajate kohtumine seoses Euroopa Liidu poolt rahastatava Comenius1 projektiga Min-E-Max (minimum energy input maximum output)

  10. Teadlastele on Saksamaa kogemus hindamatu / Mart Min, Jaan Aru

    Index Scriptorium Estoniae

    Min, Mart, 1943-

    2012-01-01

    Oma muljeid Saksamaalt jagavad Tallinna Tehnikaülikooli professor Mart Min, kes on viibinud õppejõuna Saksamaal ja Frankfurdis Max Plancki instituudis doktorantuuris aju ja teadvust uuriv noorteadlane Jaan Aru

  11. Scheduling algorithm based on modified Min-Min in grid%基于Min-Min改进后的网格调度算法

    Institute of Scientific and Technical Information of China (English)

    魏天宇; 曾文华; 黄宝边

    2005-01-01

    在对网格计算中现有的任务调度算法的研究基础上,仔细分析了调度算法中最经典的Min-Min算法,指出了该算法中所存在的负载不平衡的缺点,并在该算法的基础上提出了一个改进模型来有效的平衡负载,同时给出了相应的Balance-Min-Min算法.最后采用SimGrid工具包对所提出的算法进行仿真,验证了算法的合理性和高效性.

  12. 一类带约束min-max-min问题的区间算法%An Interval Algorithm for a Class of Constrained min-max-min Problems

    Institute of Scientific and Technical Information of China (English)

    陈美蓉; 曹德欣

    2009-01-01

    构造了求解一类带不等式约束的min-max-min问题的区间算法,其中目标函数和约束函数都是一阶连续可微函数,证明了方法的收敛性,给出了数值算例.该方法可以同时求出问题的最优值和全部全局最优解,是有效和可靠的.

  13. Meeting the 60-min physical activity guideline: Effect of operationalization

    NARCIS (Netherlands)

    Vries, S.I. de; Hopman-Rock, M.; Bakker, I.; Mechelen, W. van

    2009-01-01

    Purpose: To investigate the effect of guideline operationalization in terms of intensity threshold, bout duration, and days on the proportion of children meeting the health-related 60-min physical activity guideline using a subjective and an objective assessment method. Methods: Five hundred and twe

  14. Chain rules for smooth min-and max-entropies

    DEFF Research Database (Denmark)

    Vitanov, Alexande; Dupont-Dupuis, Fréderic; Tomamichel, Marco;

    2013-01-01

    The chain rule for the Shannon and von Neumann en- tropy, which relates the total entropy of a system to the entropies of its parts, is of central importance to information theory. Here, we consider the chain rule for the more general smooth min- and max-entropies, used in one-shot in formation t...

  15. Balance Properties and Stabilization of Min-Max Systems

    Institute of Scientific and Technical Information of China (English)

    Yue-Gang Tao; Wen-De Chen; Yi-Xin Yin

    2006-01-01

    A variety of problems in operations research, performance analysis, manufacturing, and communication networks,etc., can be modelled as discrete event systems with minimum and maximum constraints. When such systems require only maximum constraints (or dually, only minimum constraints), they can be studied using linear methods based on max-plus algebra. Systems with mixed constraints are called min-max systems in which min, max and addition operations appear simultaneously. A significant amount of work on such systems can be seen in literature. In this paper we provide some new results with regard to the balance problem of min-max functions; these are the structure properties of min-max systems.We use these results in the structural stabilization. Our main results are two sufficient conditions for the balance and one sufficient condition for the structural stabilization. The block technique is used to analyse the structure of the systems. The proposed methods, based on directed graph and max-plus algebra are constructive in nature. We provide several examples to demonstrate how the methods work in practice.

  16. Min and Max Exponential Extreme Interval Values and Statistics

    Science.gov (United States)

    Jance, Marsha; Thomopoulos, Nick

    2009-01-01

    The extreme interval values and statistics (expected value, median, mode, standard deviation, and coefficient of variation) for the smallest (min) and largest (max) values of exponentially distributed variables with parameter ? = 1 are examined for different observation (sample) sizes. An extreme interval value g[subscript a] is defined as a…

  17. Multistability and dynamic transitions of intracellular Min protein patterns.

    Science.gov (United States)

    Wu, Fabai; Halatek, Jacob; Reiter, Matthias; Kingma, Enzo; Frey, Erwin; Dekker, Cees

    2016-01-01

    Cells owe their internal organization to self-organized protein patterns, which originate and adapt to growth and external stimuli via a process that is as complex as it is little understood. Here, we study the emergence, stability, and state transitions of multistable Min protein oscillation patterns in live Escherichia coli bacteria during growth up to defined large dimensions. De novo formation of patterns from homogenous starting conditions is observed and studied both experimentally and in simulations. A new theoretical approach is developed for probing pattern stability under perturbations. Quantitative experiments and simulations show that, once established, Min oscillations tolerate a large degree of intracellular heterogeneity, allowing distinctly different patterns to persist in different cells with the same geometry. Min patterns maintain their axes for hours in experiments, despite imperfections, expansion, and changes in cell shape during continuous cell growth. Transitions between multistable Min patterns are found to be rare events induced by strong intracellular perturbations. The instances of multistability studied here are the combined outcome of boundary growth and strongly nonlinear kinetics, which are characteristic of the reaction-diffusion patterns that pervade biology at many scales. PMID:27279643

  18. The min--max construction of minimal surfaces

    OpenAIRE

    Colding, T; C. De Lellis

    2003-01-01

    In this paper we survey with complete proofs some well--known, but hard to find, results about constructing closed embedded minimal surfaces in a closed 3-dimensional manifold via min--max arguments. This includes results of J. Pitts, F. Smith, and L. Simon and F. Smith.

  19. Linked Min.B configuration inside high shear magnetic surface

    International Nuclear Information System (INIS)

    Arrangement of the l = m baseball coils to form the toroidally linked Min.B configuration with large rotational transform is studied analytically and numerically. By an optimization the closed magnetic isobars are obtained inside the last closed magnetic surface having practical volume and high shear if l = 3 baseball coils are arranged. (auth.)

  20. Mapping the MinE Site Involved in Interaction with the MinD Division Site Selection Protein of Escherichia coli

    OpenAIRE

    Ma, Lu-Yan; King, Glenn; Rothfield, Lawrence

    2003-01-01

    Interactions between the MinD and MinE proteins are required for proper placement of the Escherichia coli division septum. The site within MinE that is required for interaction with MinD was mapped by studying the effects of site-directed minE mutations on MinD-MinE interactions in yeast two-hybrid and three-hybrid experiments. This confirmed that the MinE N-terminal domain is responsible for the interaction of MinE with MinD. Mutations that interfered with the interaction defined an extended...

  1. Compensatory Fuzzy Min-Max Neural Network for Object Recognition

    Directory of Open Access Journals (Sweden)

    Paras A. Tolia

    2013-06-01

    Full Text Available Object recognition is important component in computer vision.Object recognition system (ORS is mainly concern withdetermining the identity of the object in the image. Many ORSare available but they are quite computationally expensive orthey are not invariant under rotation, translation and scale (RTS.More over fuzzy min max neural network (FMNN classifierhaving problem with classification and gradation error. Theobject recognition system is divided into two steps namely,feature extraction and pattern classification. Feature Extractionpart consist of rotation, translation and scale invariant features.These features are used to train fuzzy min max neural networkwith compensatory neuron architecture (FMCNs. FMCN useshyperbox fuzzy sets to represent the pattern classes. The conceptcompensatory neurons are inspired from the reflex system ofhuman brain which takes over the control in hazardous condition.Compensatory neurons are getting activated when the testingsample falls in the overlapped regions of different classes.

  2. Weighted Max-Min Resource Allocation for Frequency Selective Channels

    CERN Document Server

    Zehavi, Ephi; Levanda, Ronny; Han, Zhu

    2010-01-01

    In this paper, we discuss the computation of weighted max-min rate allocation using joint TDM/FDM strategies under a PSD mask constraint. We show that the weighted max-min solution allocates the rates according to a predetermined rate ratio defined by the weights, a fact that is very valuable for telecommunication service providers. Furthermore, we show that the problem can be efficiently solved using linear programming. We also discuss the resource allocation problem in the mixed services scenario where certain users have a required rate, while the others have flexible rate requirements. The solution is relevant to many communication systems that are limited by a power spectral density mask constraint such as WiMax, Wi-Fi and UWB.

  3. Theoretical Prediction of Disrupted Min Oscillation in Flattened Escherichia coli.

    Directory of Open Access Journals (Sweden)

    Jeff B Schulte

    Full Text Available The dynamics of the Min-protein system help Escherichia coli regulate the process of cell division by identifying the center of the cell. While this system exhibits robust bipolar oscillations in wild-type cell shapes, recent experiments have shown that when the cells are mechanically deformed into wide, flattened out, irregular shapes, the spatial regularity of these oscillations breaks down. We employ widely used stochastic and deterministic models of the Min system to simulate cells with flattened shapes. The deterministic model predicts strong bipolar oscillations, in contradiction with the experimentally observed behavior, while the stochastic model, which is based on the same reaction-diffusion equations, predicts more spatially irregular oscillations. We further report simulations of flattened but more symmetric shapes, which suggest that the flattening and lateral expansion may contribute as much to the irregular oscillation behavior as the asymmetry of the cell shapes.

  4. Optimal Control of (Min,+) Linear Time-Varying Systems

    OpenAIRE

    Lahaye, Sébastien; Boimond, Jean-Louis; Hardouin, Laurent

    1999-01-01

    International audience The class of discrete event dynamic systems involving only synchronization phenomena can be seen as linear time-invariant systems in a particular algebraic structure called (min,+) algebra. In the same framework, this paper deals with linear time-varying systems, that is, systems whose parameters may change as functions of time. For example, in a manufacturing system the number of working machines, or the number of trains running in a closed network of railway connec...

  5. Min-max minimal hypersurfaces in non-compact manifolds

    OpenAIRE

    Montezuma, Rafael

    2014-01-01

    In this work we prove the existence of embedded closed minimal hypersurfaces in non-compact manifolds containing a bounded open subset with smooth and strictly mean-concave boundary and a natural behavior on the geometry at infinity. For doing this, we develop a modified min-max theory for the area functional following Almgren and Pitts' setting, to produce minimal surfaces with intersecting properties.

  6. Landscape pattern change in the upper valley of Min River

    Institute of Scientific and Technical Information of China (English)

    ZHAO Yong-hua; HE Xing-yuan; HU Yuan-man; CHANG Yu

    2005-01-01

    The upper valley of Min River (102° 59′ -104° 14′ E, 31° 26′ - 33° 16′ N), which is consisted of the counties Wenchuan, Maoxian, Lixian, Heishui, and Songpan, refers to the part up to Dujiangyan City, and locates on the transition zone from the Tibetan Plateau to the Sichuan Basin. It is one of the most important forest areas in China, especially in Sichuan Province. Over past two decades, the landscape changed remarkably in the region. The 3S techniques (Remote Sensing (RS), Geographic Information System (GIS) and Global Position System (GPS)) were used to classify the images and analyze the landscape change. The remotely sensed data of Landsat TM 1986 and Landsat ETM+ 2000 were used to analyze the landscape change of the region. The landscape were classified into 10 types of cropland, forest, shrub land, economic forest, grassland, build up land, river, lake, swamp, and unused land. The results showed that: 1) the woodland and grassland were dominating landscape types in the upper valley of Min River, which is more than 91% of the study area; 2) the alteration of the landscape was mainly happened among forest, shrub land, grassland, economic forest, cropland, and build up land, where forest decreased from 51.17% to 47.56%; 3) the landscape fragmentation in the upper valley of Min River was aggravated from 1986 to 2000.

  7. Creating a Scandinavian brunch for BistroCafe Min Krog

    OpenAIRE

    Häkämies, Pilvi

    2015-01-01

    This thesis is about creating a Scandinavian brunch menu and a brunch product for BistroCafé Min Krog located in Kirkkonummi, Finland. The goal of this thesis is to give a clear framework for creating a brunch menu for a restaurant. I planned and executed the Scandinavian brunch used as a case in this thesis in October 2013. The timeframe of this thesis is from October 2013 until August 2015. The thesis consists of theoretical background related to new-product development and menu planni...

  8. John Disks, the Apollonian Metric, and Min-Max Properties

    Indian Academy of Sciences (India)

    M Huang; S Ponnusamy; X Wang

    2010-02-01

    The main results of this paper are characterizations of John disks–the simply connected proper subdomains of the complex plane that satisfy a twisted double cone connectivity property. One of the characterizations of John disks is an analog of a result due to Gehring and Hag who found such a characterization for quasidisks. In both situations the geometric condition is an estimate for the domain’s hyperbolic metric in terms of its Apollonian metric. The other characterization is in terms of an arc min-max property.

  9. Minätys! Lapsen itsetunnon tukeminen draamallisin menetelmin

    OpenAIRE

    Visuri, Sanna-Maaria

    2015-01-01

    Tutkimuksen tarkoituksena on selvittää miten draamamenetelmillä voi tukea lapsen itsetunnon kehitystä. Opinnäytetyö on tehty yhteistyössä Kokkolan sosiaali- ja terveystoimen alaisen yksikön Isokadun perhepalvelukeskuksen kanssa. Kohderyhmänä oli lastensuojelun tarpeessa olevien perheiden 8-12 vuotiaat lapset. Kokonaisuudessaan työ koostuu toiminnallisesta osuudesta sekä teoriaosuudesta. Tutkimuksen toiminnallisessa osuudessa järjestin draamapainotteisen Minätys- pajan helmikuussa 1.2.14-2...

  10. Grayscale Image Compression Based on Min Max Block Truncating Coding

    Directory of Open Access Journals (Sweden)

    Hilal Almarabeh

    2011-11-01

    Full Text Available This paper presents an image compression techniques based on block truncating coding. In this work, a min max block truncating coding (MM_BTC is presented for grayscale image compression relies on applying dividing image into non-overlapping blocks. MM_BTC differ from other block truncating coding such as block truncating coding (BTC in the way of selecting the quantization level in order to remove redundancy. Objectives measures such as: Bit Rate (BR, Mean Square Error (MSE, Peak Signal to Noise Ratio (PSNR, and Redundancy (R, were used to present a detailed evaluation of MM_BTC of image quality.

  11. Min-max event-triggered computation tree logic

    Indian Academy of Sciences (India)

    Pallab Dasgupta; P P Chakrabarti; Jatindra Kumar Deka

    2002-04-01

    Very often timing verification involves the analysis of the timings of discrete events such as signal changes, sending and receiving of signals, and sensitization of edge-triggered circuit components. The main bottleneck in verifying timing properties of timed finite state machines (FSM) has been the inherent complexity of verifying timed properties (PSPACE-complete for timed extensions of computational tree logic (CTL)). Often however, we are interested in the best case or worst case timings between events. In this paper we introduce a temporal query language called Min-max Event-Triggered Computational Tree Logic for expressing such extremal queries on the timings of events and show that such queries can be evaluated in time polynomial in the size of the system times the length of the formula.

  12. Transmembrane Helix Assembly by Max-Min Ant System Algorithm.

    Science.gov (United States)

    Sujaree, Kanon; Kitjaruwankul, Sunan; Boonamnaj, Panisak; Supunyabut, Chirayut; Sompornpisut, Pornthep

    2015-12-01

    Because of the rapid progress in biochemical and structural studies of membrane proteins, considerable attention has been given on developing efficient computational methods for solving low-to-medium resolution structures using sparse structural data. In this study, we demonstrate a novel algorithm, max-min ant system (MMAS), designed to find an assembly of α-helical transmembrane proteins using a rigid helix arrangement guided by distance constraints. The new algorithm generates a large variety with finite number of orientations of transmembrane helix bundle and finds the solution that is matched with the provided distance constraints based on the behavior of ants to search for the shortest possible path between their nest and the food source. To demonstrate the efficiency of the novel search algorithm, MMAS is applied to determine the transmembrane packing of KcsA and MscL ion channels from a limited distance information extracted from the crystal structures, and the packing of KvAP voltage sensor domain using a set of 10 experimentally determined constraints, and the results are compared with those of two popular used stochastic methods, simulated annealing Monte Carlo method and genetic algorithm. PMID:26058409

  13. Min-cut segmentation of cursive handwriting in tabular documents

    Science.gov (United States)

    Davis, Brian L.; Barrett, William A.; Swingle, Scott D.

    2015-01-01

    Handwritten tabular documents, such as census, birth, death and marriage records, contain a wealth of information vital to genealogical and related research. Much work has been done in segmenting freeform handwriting, however, segmentation of cursive handwriting in tabular documents is still an unsolved problem. Tabular documents present unique segmentation challenges caused by handwriting overlapping cell-boundaries and other words, both horizontally and vertically, as "ascenders" and "descenders" overlap into adjacent cells. This paper presents a method for segmenting handwriting in tabular documents using a min-cut/max-flow algorithm on a graph formed from a distance map and connected components of handwriting. Specifically, we focus on line, word and first letter segmentation. Additionally, we include the angles of strokes of the handwriting as a third dimension to our graph to enable the resulting segments to share pixels of overlapping letters. Word segmentation accuracy is 89.5% evaluating lines of the data set used in the ICDAR2013 Handwriting Segmentation Contest. Accuracy is 92.6% for a specific application of segmenting first and last names from noisy census records. Accuracy for segmenting lines of names from noisy census records is 80.7%. The 3D graph cutting shows promise in segmenting overlapping letters, although highly convoluted or overlapping handwriting remains an ongoing challenge.

  14. Variable operator technique and the min-max theorem

    Indian Academy of Sciences (India)

    Sambhu Nath Datta

    2000-09-01

    We investigate a variation method where the trial function is generated from the application of a variable operator on a reference function. Two conditions are identified, one for obtaining a maximum and another for a minimum. Although the conditions are easy to understand, the overall formulation is somewhat unusual as each condition gives rise to a two-step variation process. As an example, projection operators are used to form the variable operator, and by this tactics one obtains the new interpretation that the pseudopotential formalism is in fact equivalent to a minimax procedure. The two-step variational process is nevertheless more flexible than the pseudopotential formalism, for it can also be used when the variable operator isnot manifestly expressed in terms of projectors. This is illustrated by a comparison of the two-step method with the variational solution of Dirac’s relativistic electron equation. The same comparison leads to an alternative proof that the process of maximizing energy by varying the – coupling operator eliminates all negative-energy contributions from a trial spinor. The latter observation is crucial for the derivation of the min-max theorem in relativistic quantum mechanics.

  15. Topic Modeling for Keyword Extraction: using Natural Language Processing methods for keyword extraction in Portal Min@s

    Directory of Open Access Journals (Sweden)

    Arnaldo Candido Junior

    2015-12-01

    Full Text Available Este artigo tem o objetivo da avaliar a aplicação de dois métodos automáticos eficientes na extração de palavras-chave, usados pelas comunidades da Linguística de Corpus e do Processamento da Língua Natural para gerar palavras-chave de textos literários: o WordSmith Tools e o Latent Dirichlet Allocation (LDA. As duas ferramentas escolhidas para este trabalho têm suas especificidades e técnicas diferentes de extração, o que nos levou a uma análise orientada para a sua performance. Objetivamos entender, então, como cada método funciona e avaliar sua aplicação em textos literários. Para esse fim, usamos análise humana, com conhecimento do campo dos textos usados. O método LDA foi usado para extrair palavras-chave por meio de sua integração com o Portal Min@s: Corpora de Fala e Escrita, um sistema geral de processamento de corpora, concebido para diferentes pesquisas de Linguística de Corpus. Os resultados do experimento confirmam a eficácia do WordSmith Tools e do LDA na extração de palavras-chave de um corpus literário, além de apontar que é necessária a análise humana das listas em um estágio anterior aos experimentos para complementar a lista gerada automaticamente, cruzando os resultados do WordSmith Tools e do LDA. Também indicam que a intuição linguística do analista humano sobre as listas geradas separadamente pelos dois métodos usados neste estudo foi mais favorável ao uso da lista de palavras-chave do WordSmith Tools.

  16. a Min-Cut Based Filter for Airborne LIDAR Data

    Science.gov (United States)

    Ural, Serkan; Shan, Jie

    2016-06-01

    LiDAR (Light Detection and Ranging) is a routinely employed technology as a 3-D data collection technique for topographic mapping. Conventional workflows for analyzing LiDAR data require the ground to be determined prior to extracting other features of interest. Filtering the terrain points is one of the fundamental processes to acquire higher-level information from unstructured LiDAR point data. There are many ground-filtering algorithms in literature, spanning several broad categories regarding their strategies. Most of the earlier algorithms examine only the local characteristics of the points or grids, such as the slope, and elevation discontinuities. Since considering only the local properties restricts the filtering performance due to the complexity of the terrain and the features, some recent methods utilize global properties of the terrain as well. This paper presents a new ground filtering method, Min-cut Based Filtering (MBF), which takes both local and global properties of the points into account. MBF considers ground filtering as a labeling task. First, an energy function is designed on a graph, where LiDAR points are considered as the nodes on the graph that are connected to each other as well as to two auxiliary nodes representing ground and off-ground labels. The graph is constructed such that the data costs are assigned to the edges connecting the points to the auxiliary nodes, and the smoothness costs to the edges between points. Data and smoothness terms of the energy function are formulated using point elevations and approximate ground information. The data term conducts the likelihood of the points being ground or off-ground while the smoothness term enforces spatial coherence between neighboring points. The energy function is optimized by finding the minimum-cut on the graph via the alpha-expansion algorithm. The resulting graph-cut provides the labeling of the point cloud as ground and off-ground points. Evaluation of the proposed method on

  17. Genetic Mapping of the minB Locus in Escherichia coli K-12

    OpenAIRE

    Schaumberg, Thomas H.; Kuempel, Peter L.

    1983-01-01

    The minB (minicell production) locus of Escherichia coli K-12 was mapped by transduction using bacteriophage P1. minB is located at min 25.6, between purB (min 25.2) and dadR (min 25.8). The mapping was facilitated by the use of insertion zcf-236::Tn10, which is inserted at min 25.4.

  18. Detection of active bile leak with Gd-EOB-DTPA enhanced MR cholangiography: Comparison of 20–25 min delayed and 60–180 min delayed images

    Energy Technology Data Exchange (ETDEWEB)

    Cieszanowski, Andrzej, E-mail: andrzej.cieszanowski@wum.edu.pl [2nd Department of Clinical Radiology, Medical University of Warsaw, ul. Banacha 1A, 02-097 Warszawa (Poland); Stadnik, Anna, E-mail: aniaws@yahoo.com [2nd Department of Clinical Radiology, Medical University of Warsaw, ul. Banacha 1A, 02-097 Warszawa (Poland); Lezak, Aleksandra, E-mail: aleksandralezak@gmail.com [2nd Department of Clinical Radiology, Medical University of Warsaw, ul. Banacha 1A, 02-097 Warszawa (Poland); Maj, Edyta, E-mail: em26@wp.pl [2nd Department of Clinical Radiology, Medical University of Warsaw, ul. Banacha 1A, 02-097 Warszawa (Poland); Zieniewicz, Krzysztof, E-mail: krzysztof.zieniewicz@wum.edu.pl [Chair and Department of General, Transplant and Liver Surgery, Medical University of Warsaw, ul. Banacha 1A, 02-097 Warszawa (Poland); Rowinska-Berman, Katarzyna, E-mail: kasiarowinska@wp.pl [2nd Department of Clinical Radiology, Medical University of Warsaw, ul. Banacha 1A, 02-097 Warszawa (Poland); Grudzinski, Ireneusz P., E-mail: ireneusz.grudzinski@wum.edu.pl [Department of Toxicology, Medical University of Warsaw, Faculty of Pharmacy, ul. Banacha 1, 02-097 Warsaw (Poland); Krawczyk, Marek, E-mail: marek.krawczyk@wum.edu.pl [Chair and Department of General, Transplant and Liver Surgery, Medical University of Warsaw, ul. Banacha 1A, 02-097 Warszawa (Poland); Rowiński, Olgierd, E-mail: olgierd.rowinski@wum.edu.pl [2nd Department of Clinical Radiology, Medical University of Warsaw, ul. Banacha 1A, 02-097 Warszawa (Poland)

    2013-12-01

    Objectives: The purpose of this study was to assess the value of contrast-enhanced magnetic resonance cholangiography (MRC) performed in different time delays after injection of gadoxetic acid disodium (Gd-EOB-DTPA) for the diagnosis of active bile leak. Methods: This retrospective analysis included Gd-EOB-DTPA enhanced MR images of 34 patients suspected of bile leak. Images were acquired 20–25 min after Gd-EOB-DTPA injection. If there was inadequate contrast in the bile ducts then delayed images after 60–90 min and 150–180 min were obtained. Results were correlated with intraoperative findings, ERCP results, clinical data, laboratory tests, and follow-up examinations. Results: Gd-EOB-DTPA enhanced MRC yielded an overall sensitivity of 96.4%, specificity of 100% and accuracy of 97.1% for the diagnosis of an active bile leak. The sensitivity of 20–25 min delayed MR images was 42.9%, of combined 20–25 min and 60–90 min delayed images was 92.9% and of combined 20–25 min, 60–90 min and 150–180 min delayed images was 96.4%. Conclusions: Gd-EOB-DTPA enhanced MRC utilizing delayed phase images was effective for detecting the presence and location of active bile leaks. The images acquired 60–180 min post-injection enabled identification of bile leaks even in patients with a dilated biliary system or moderate liver dysfunction.

  19. Maintenance of the cell morphology by MinC in Helicobacter pylori.

    Directory of Open Access Journals (Sweden)

    Pei-Yu Chiou

    Full Text Available In the model organism Escherichia coli, Min proteins are involved in regulating the division of septa formation. The computational genome analysis of Helicobacter pylori, a gram-negative microaerophilic bacterium causing gastritis and peptic ulceration, also identified MinC, MinD, and MinE. However, MinC (HP1053 shares a low identity with those of other bacteria and its function in H. pylori remains unclear. In this study, we used morphological and genetic approaches to examine the molecular role of MinC. The results were shown that an H. pylori mutant lacking MinC forms filamentous cells, while the wild-type strain retains the shape of short rods. In addition, a minC mutant regains the short rods when complemented with an intact minCHp gene. The overexpression of MinCHp in E. coli did not affect the growth and cell morphology. Immunofluorescence microscopy revealed that MinCHp forms helix-form structures in H. pylori, whereas MinCHp localizes at cell poles and pole of new daughter cell in E. coli. In addition, co-immunoprecipitation showed MinC can interact with MinD but not with FtsZ during mid-exponential stage of H. pylori. Altogether, our results show that MinCHp plays a key role in maintaining proper cell morphology and its function differs from those of MinCEc.

  20. GridSim Simulation of Min-min Task Scheduling Algorithm in Grid%网格任务调度算法Min-min的GridSim模拟实现

    Institute of Scientific and Technical Information of China (English)

    苏翊

    2010-01-01

    该文用模拟方法研究网格中的任务调度问题.首先对Min-min算法进行分析,然后用Gridsim对Min-min调度算法进行模拟实现,阐述了实现过程,并统计模拟结果,对Min-min算法的MakeSpan和负载等性能进行了分析,验证了模拟实现过程的正确性.

  1. Intrinsic characteristics of Min proteins on the cell division of Helicobacter pylori.

    Science.gov (United States)

    Nishida, Yoshie; Takeuchi, Hiroaki; Morimoto, Norihito; Umeda, Akiko; Kadota, Yoshu; Kira, Mizuki; Okazaki, Ami; Matsumura, Yoshihisa; Sugiura, Tetsuro

    2016-03-01

    Helicobacter pylori divides in the human stomach resulting in persistent infections and causing various disorders. Bacterial cell division is precisely coordinated by many molecules, including FtsZ and Min proteins. However, the role of Min proteins in H. pylori division is poorly understood. We investigated the functional characteristics of Min proteins in wild-type HPK5 and five HPK5-derivative mutants using morphological and genetic approaches. All mutants showed a filamentous shape. However, the bacterial cell growth and viability of three single-gene mutants (minC, minD, minE) were similar to that of the wild-type. The coccoid form number was lowest in the minE-disruptant, indicating that MinE contributes to the coccoid form conversion during the stationary phase. Immunofluorescence microscopic observations showed that FtsZ was dispersedly distributed throughout the bacterial cell irrespective of nucleoid position in only minD-disruptants, indicating that MinD is involved in the nucleoid occlusion system. A chase assay demonstrated that MinC loss suppressed FtsZ-degradation, indicating that FtsZ degrades in a MinC-dependent manner. Molecular interactions between FtsZ and Min proteins were confirmed by immunoprecipitation (IP)-western blotting (WB), suggesting the functional cooperation of these molecules during bacterial cell division. This study describes the intrinsic characteristics of Min proteins and provides new insights into H. pylori cell division.

  2. Isolation and characterization of topological specificity mutants of minD in Bacillus subtilis

    OpenAIRE

    Karoui, M E; Errington, J

    2001-01-01

    In rod-shaped bacteria such as Bacillus subtilis, division site selection is mediated by MinC and MinD, which together function as a division inhibitor. Topological specificity is imposed by DivIVA, which ensures that MinCD specifically inhibits division close to the cell poles, while allowing division at mid-cell. MinD plays a central role in this process, as it positions and activates MinC and is dependent on DivIVA for its own positioning at the poles. To investigate MinD activities furthe...

  3. 无向图中边不相交Min-Min问题的复杂度%Hardness of the edge-disjoint Min-Min problem in undirected graphs

    Institute of Scientific and Technical Information of China (English)

    郭龙坤; 沈鸿

    2012-01-01

    We show incorrectness of the NP-completeness proof of Bhatia et al.for the edge-disjoint Min-Min problem in undirected graphs,by giving a counter example that is an unsatisfiable 3SAT instance but was classified satisfiable in the proof of Bhatia etal. We then give a proof of NP-completeness of the edge-disjoint Min-Min problem in undirected graphs,based on a reduction from the MAX-2SAT problem.%Bhatia等指出,Xu等对无向图中的边不相交Min-Min问题的NP-完全性证明并不成立.我们首先用一个反例指出Bhatia等对Xu等的NP-完全性证明的修正依然存在错误.基于一个从MAX-2SAT的归约,我们给出了一个无向图中边不相交Min-Min问题的NP-完全性的正确证明.

  4. Min mentor er min voksenven

    DEFF Research Database (Denmark)

    Kaiser, Birte

    2009-01-01

    En artikel i bogen: 6 belysninger af vejledning, brydninger, forståelser & praksis. Artiklen er et sammendrag af en diskursanalyse fra 2008 fra projetrapporten: Ind under huden, www.vejledning.net...

  5. 基于带抑制弧的Petri网的min-min算法模型研究%Research on min-min algorithm model based on Petri net model with inhibitor arcs

    Institute of Scientific and Technical Information of China (English)

    傅游; 花嵘; 田银花

    2010-01-01

    为了解决已有的min-min算法Petri网模型不能模拟min-min算法运行过程的问题,根据min-min算法的调度特点,利用带抑制弧的Petri网提出了一种算法模型,该模型运行过程可以严格模拟min-min算法对独立任务集的调度顺序,能够正确地描述独立任务调度系统使用min-min算法的情况.最后对该模型的空间复杂度以及每调度一个任务模型的变化情况进行了分析,随着独立任务的调度执行,该基于带抑制弧的Petri网的变迁数和弧数会随之减少,模型的空间复杂度会不断降低.

  6. Changes in the Min oscillation pattern before and after cell birth.

    Science.gov (United States)

    Juarez, Jennifer R; Margolin, William

    2010-08-01

    The Min system regulates the positioning of the cell division site in many bacteria. In Escherichia coli, MinD migrates rapidly from one cell pole to the other. In conjunction with MinC, MinD helps to prevent unwanted FtsZ rings from assembling at the poles and to stabilize their positioning at midcell. Using time-lapse microscopy of growing and dividing cells expressing a gfp-minD fusion, we show that green fluorescent protein (GFP)-MinD often paused at midcell in addition to at the poles, and the frequency of midcell pausing increased as cells grew longer and cell division approached. At later stages of septum formation, GFP-MinD often paused specifically on only one side of the septum, followed by migration to the other side of the septum or to a cell pole. About the time of septum closure, this irregular pattern often switched to a transient double pole-to-pole oscillation in the daughter cells, which ultimately became a stable double oscillation. The splitting of a single MinD zone into two depends on the developing septum and is a potential mechanism to explain how MinD is distributed equitably to both daughter cells. Septal pausing of GFP-MinD did not require MinC, suggesting that MinC-FtsZ interactions do not drive MinD-septal interactions, and instead MinD recognizes a specific geometric, lipid, and/or protein target at the developing septum. Finally, we observed regular end-to-end oscillation over very short distances along the long axes of minicells, supporting the importance of geometry in MinD localization. PMID:20543068

  7. Local Optimization for Task Scheduling Algorithm Based on QoS Guided Min-min%基于QoS Guided Min-min任务调度算法局部优化

    Institute of Scientific and Technical Information of China (English)

    王祖析

    2011-01-01

    在对网格环境中现有任务调度算法的研究基础上,分析了调度算法中经典的Min-Min算法和Qos GuidedMin-min算法,指出了这些算法中所存在的负载不平衡的缺点,在此基础上,提出对Qos Guided Min-min算法进行局部优化和改进,并采用SimGrid模拟器对优化的算法进行仿真,结果表明,优化改进后的算法合理,具有较高的性能.

  8. A Grid Task Scheduling Method Based on Min-Min and ACO Algorithm%基于Min-Min和蚁群算法的网格任务调度方法

    Institute of Scientific and Technical Information of China (English)

    黄学雨; 何焕; 戴志晃

    2009-01-01

    网格任务调度是网格计算的研究热点,也是一个NP难问题.文章结合Min-Min算法和蚁群算法的优点,提出了一种基于Min-Min蚁群算法(MMACO)的任务调度方法.仿真实验表明:在网格环境下,该算法具有较好的全局最优求解能力和较快的收敛速度.

  9. Stuttering Min oscillations within E. coli bacteria: a stochastic polymerization model

    International Nuclear Information System (INIS)

    We have developed a 3D off-lattice stochastic polymerization model to study the subcellular oscillation of Min proteins in the bacteria Escherichia coli, and used it to investigate the experimental phenomenon of Min oscillation stuttering. Stuttering was affected by the rate of immediate rebinding of MinE released from depolymerizing filament tips (processivity), protection of depolymerizing filament tips from MinD binding and fragmentation of MinD filaments due to MinE. Processivity, protection and fragmentation each reduce stuttering, speed oscillations and MinD filament lengths. Neither processivity nor tip protection were, on their own, sufficient to produce fast stutter-free oscillations. While filament fragmentation could, on its own, lead to fast oscillations with infrequent stuttering; high levels of fragmentation degraded oscillations. The infrequent stuttering observed in standard Min oscillations is consistent with short filaments of MinD, while we expect that mutants that exhibit higher stuttering frequencies will exhibit longer MinD filaments. Increased stuttering rate may be a useful diagnostic to find observable MinD polymerization under experimental conditions. (paper)

  10. AREVA announces US$ 7.75 Per share friendly cash offer for UraMin

    International Nuclear Information System (INIS)

    AREVA and UraMin Inc. ('UraMin') entered on June 15, 2007 into an agreement in respect of AREVA's friendly cash offer for 100% of the share capital of UraMin. UraMin is listed in London (AIM) and Toronto (TSX). AREVA (Euronext Paris) already owns 5.5% of UraMin's share capital. This cash offer of AREVA will be made through its indirect wholly-owned subsidiary CFMM Development ('AREVA') based on a price of US$ 7.75 per UraMin share. The total offer consideration amounts to more than USD 2.5 billion for 100% of the fully diluted share capital of UraMin. This represents a premium of 21% over UraMin 20-day weighted average trading price ending on June 8, 2007. The UraMin Board of Directors, after consulting with its financial advisors, has determined that the offer is fair and in the best interest of the UraMin shareholders and it has resolved to recommend acceptance of the Offer. BMO Capital Markets has provided an opinion that the offer is fair, from a financial point of view, to the UraMin shareholders. In connection with the offer, all directors and certain other shareholders representing approximately 25% of the outstanding UraMin shares (calculated on a fully diluted basis) have entered into lock-up agreements with AREVA pursuant to which they have agreed to tender all their UraMin shares to AREVA's offer. The support agreement entered into between AREVA and UraMin provides for, among other things, in case a superior proposal is accepted by UraMin, a right to match in favour of AREVA. The support agreement also includes a break up fee in favour of AREVA of US$ 75 million under certain circumstances. Concurrently with the closing of the proposed offer, UraMin will declare a dividend payable in shares of the capital of Niger Uranium Limited held by UraMin (where permitted by law) or a cash equivalent of the value of such shares

  11. Serial Min-max Decoding Algorithm Based on Variable Weighting for Nonbinary LDPC Codes

    Directory of Open Access Journals (Sweden)

    Zhongxun Wang

    2013-09-01

    Full Text Available In this paper, we perform an analysis on the min-max decoding algorithm for nonbinary LDPC(low-density parity-check codes and propose serial min-max decoding algorithm. Combining with the weighted processing of the variable node message, we propose serial min-max decoding algorithm based on variable weighting for nonbinary LDPC codes in the end. The simulation indicates that when the bit error rate is 10^-3,compared with serial min-max decoding algorithm ,traditional min-max decoding algorithm and traditional minsum algorithm ,serial min-max decoding algorithm based on variable weighting can offer additional coding gain 0.2dB、0.8dB and 1.4dB respectively in additional white Gaussian noise channel and under binary phase shift keying modulation.  

  12. Radiation-induced intestinal neoplasia in a genetically-predisposed mouse (Min)

    Energy Technology Data Exchange (ETDEWEB)

    Ellender, M.; Larder, S.M.; Harrison, J.D.; Cox, R.; Silver, A.R.J. [National Radiological Protection Board, Chilton (United Kingdom)

    1997-03-01

    A mouse lineage with inherited predisposition to multiple intestinal neoplasia (min) has been proposed as a model to study human colorectal cancer. Min mice are heterozygous for the adenomatous polyposis coli (Apc) gene implicated in human familial adenomatous polyposis (FAP). There is an increased risk of intestinal cancer in humans following radiation exposure and the min mouse model may be used to further our understanding of the molecular mechanisms involved. The present study showed a 2 Gy dose of x-rays doubles the tumour numbers in the murine gastrointestinal tract of F1 min heterozygotes. The distribution of tumours through the gut was also recorded. (authors)

  13. MinCD Proteins Control the Septation Process during Sporulation of Bacillus subtilis

    OpenAIRE

    Barák, Imrich; Prepiak, Peter; Schmeisser, Falko

    1998-01-01

    Mutation of the divIVB locus in Bacillus subtilis causes misplacement of the septum during cell division and allows the formation of anucleate minicells. The divIVB locus contains five open reading frames (ORFs). The last two ORFs (minCD) are homologous to minC and minD of Escherichia coli but a minE homolog is lacking in B. subtilis. There is some similarity between minicell formation and the asymmetric septation that normally occurs during sporulation in terms of polar septum localization. ...

  14. Cloning and Sequence Analysis of Y-box Binding Protein Gene in Min Pig

    Institute of Scientific and Technical Information of China (English)

    Zhang Dong-jie; Liu Di; Wang Liang; He Xin-miao; Wang Wen-tao

    2014-01-01

    In order to study the gene sequence of Min pig Y-box binding protein (YB-1) gene, the complete coding sequence of Min pig YB-1 gene was cloned by RT-PCR, the sequence features were analyzed by some software and online website. The results showed that the complete CDS of Min pig Y-box was found to be 975 bp long, encoding 324 amino acids. It contained a conserved cold shock domain and several phosphorylation sites, but had no transmembrane domains, and was consistent with a protein found in the cytoplasm. Min pig YB-1 nucleotides shared high similarity (61.37%-97.66%) with other mammals.

  15. Quality control of the 113Sn-113mIn generator

    International Nuclear Information System (INIS)

    Methods for quality control of 113Sn-113mIn generators are compared and recommended the most convenient to applicate in hospitals and in more specialized quality control laboratories. The quality of 113Sn-113mIn generator produced by POLATOM (Poland) is also evaluated. The product met the requirements of the International Pharmacopeia

  16. Hydrothermal plumes along the East Pacific Rise, 8 deg 40 min to 11 deg 50 min N: Particle distribution and composition

    Science.gov (United States)

    Feely, R. A.; Gendron, J. F.; Baker, E. T.; Lebon, G. T.

    1994-11-01

    The discovery of a volcanic eruption at the 9 deg 45.52 min N site on the East Pacific Rise (EPR) led us to investigate how the composition of suspended matter in hydrothermal plumes may be used to provide a better understanding of the relative age and vent fluid characteristics of a ridge crest system during surface ship surveys. During the TROUGHS (Tropical Ridge Observations of Underwater Geochemical Hydrothermal Signals) expedition we collected hydrothermal plume particles along a 350 km section, extending from approximately 8 deg 40 min N to 11 deg 50 min N, of the EPR north and south of the Clipperton Transform Fault. Over the segment south of the Clipperton Transform Fault, the S/Fe ratio in the particles ranged from about 0.9 to 10, with the highest values immediately over the new vent field at the 9 deg 45.52 min N site. These enrichments exactly coincide with the elevated He-3/heat and CH4/Mn ratios in the plumes over the same vent field. The S-rich particles are primarily organic and may be related to the 'bacteria blizzard' associated with the eruption. In addition, very high Cu/Fe and Zn/Fe ratios were observed in the hydrothermal plumes south of the Clipperton Transform Fault. These high ratios are indicative of the predominance of high-temperature, H2S-rich vents between 9 deg 35 min N and 9 deg 50 min N. In contrast, the samples from the segment north of Clipperton Transform Fault and S/Fe ratios which ranged from 0.04 to 0.82, typical of mature, Fe-rich hydrothermal plumes. These results suggest that the gas-rich vent fluids at the 9 deg 45.52 min N site produced the sulfur-enriched particles in the water column. Gas-rich plumes and sulfur-enriched plume particles were also observed underneath the 1986 Megaplume on the Juan de Fuca Ridge (JdFR), suggesting a similar mode of formation. North of the Clipperton Transform Fault, the hydrothermal particles are dominated by Fe-rich oxyhydroxide particles, characteristic of mature high-temperature vent

  17. Frequency drifts of 3-min oscillations in microwave and EUV emission above sunspots

    CERN Document Server

    Sych, R; Nakariakov, V M; Anfinogentov, S A; Shibasaki, K; Yan, Y

    2011-01-01

    We analyse 3-min oscillations of microwave and EUV emission generated at different heights of a sunspot atmosphere, studying the amplitude and frequency modulation of the oscillations, and its relationship with the variation of the spatial structure of the oscillations. High-resolution data obtained with the Nobeyama Radioheliograph, TRACE and SDO/AIA are analysed with the use of the Pixelised Wavelet Filtering and wavelet skeleton techniques. 3-min oscillations in sunspots appear in the form of repetitive trains of the duration 8-20 min (13 min in average). The typical interval between the trains is 30-50 min. The oscillation trains are transient in frequency and power. We detected a repetitive frequency drifts of 3-min oscillations during the development of individual trains. Wavelet analysis shows three types of the frequency drift: positive, negative and fluctuations without drift. The start and end of the drifts coincide with the start time and end of the train. The comparative study of 3-min oscillation...

  18. Sustained Aftereffect of α-tACS Lasts Up to 70 min after Stimulation

    Science.gov (United States)

    Kasten, Florian H.; Dowsett, James; Herrmann, Christoph S.

    2016-01-01

    Transcranial alternating current stimulation (tACS) has been repeatedly demonstrated to increase power of endogenous brain oscillations in the range of the stimulated frequency after stimulation. In the alpha band this aftereffect has been shown to persist for at least 30 min. However, in most experiments the aftereffect exceeded the duration of the measurement. Thus, it remains unclear how the effect develops beyond these 30 min and when it decays. The current study aimed to extend existing findings by monitoring the physiological aftereffect of tACS in the alpha range for an extended period of 90 min post-stimulation. To this end participants received either 20 min of tACS or sham stimulation with intensities below their individual sensation threshold at the individual alpha frequency (IAF). Electroencephalogram (EEG) was acquired during 3 min before and 90 min after stimulation. Subjects performed a visual vigilance task during the whole measurement. While the enhanced power in the individual alpha band did not return back to pre-stimulation baseline in the stimulation group, the difference between stimulation and sham diminishes after 70 min due to a natural alpha increase of the sham group. PMID:27252642

  19. Extensive metabolic disorders are present in APC(min) tumorigenesis mice.

    Science.gov (United States)

    Liu, Zhenzhen; Xiao, Yi; Zhou, Zhengxiang; Mao, Xiaoxiao; Cai, Jinxing; Xiong, Lu; Liao, Chaonan; Huang, Fulian; Liu, Zehao; Ali Sheikh, Md Sayed; Plutzky, Jorge; Huang, He; Yang, Tianlun; Duan, Qiong

    2016-05-15

    Wnt signaling plays essential role in mesenchymal stem cell (MSC) differentiation. Activation of Wnt signaling suppresses adipogenesis, but promotes osteogenesis in MSC. Adenomatous polyposis coli (APC) is a negative regulator of β-catenin and Wnt signaling activity. The mutation of APC gene leads to the activation of Wnt signaling and is responsible for tumorigenesis in APC(min) mouse; however, very few studies focused on its metabolic abnormalities. The present study reports a widespread metabolic disorder phenotype in APC(min) mice. The old APC(min) mice have decreased body weight and impaired adipogenesis, but severe hyperlipidemia, which mimic the phenotypes of Familial Adenomatous Polyposis (FAP), an inherited disease also caused by APC gene mutation in human. We found that the expression of lipid metabolism and free fat acids (FA) use genes in the white adipose tissue (WAT) of the APC(min) mice is much lower than those of control. The changed gene expression pattern may lead to the disability of circulatory lipid transportation and storage at WAT. Moreover, the APC(min) mice could not maintain the core body temperature in cold condition. PET-CT determination revealed that the BAT of APC(min) mice has significantly impaired ability to take up (18)FDG from the blood. Morphological studies identified that the brown adipocytes of APC(min) mice were filled with lipid droplets but fewer mitochondria. These results matched with the findings of impaired BAT function in APC(min) mice. Collectively, our study explores a new mechanism that explains abnormal metabolism in APC(min) mice and provides insights into studying the metabolic disorders of FAP patients. PMID:26948948

  20. Mapping of multiple intestinal neoplasia (Min) to proximal chromosome 18 of the mouse

    Energy Technology Data Exchange (ETDEWEB)

    Luongo, C.; Gould, K.A.; Moser, A.R. (Univ. of Wisconsin, Madison (United States)); Su, Likuo; Kinzler, K.W.; Vogelstein, B. (Johns Hopkins Oncology Center, Baltimore, MD (United States)); Dietrich, W.; Lander, E.S. (MIT, Cambridge (United States))

    1993-01-01

    The Min (multiple intestinal neoplasia) mutation of the mouse has been mapped by analyzing the inheritance of restriction fragment length polymorphisms and simple sequence length polymorphisms in progeny from two intraspecific crosses segregating for the Min mutation. Min, a mutant allele of Apc, the mouse homo- log of the human APC (adenomatous polyposis coli) gene, maps to proximal chromosome 18. The synteny between Apc and Mcc, the mouse homolog of the human MCC (mutated in colorectal cancer) gene, is conserved between mouse and human, although the gene order in the Apc to Mcc interval is different from that in the APC to MCC interval. 29 refs., 3 figs.

  1. Asymptotic identity in min-plus algebra: a report on CPNS.

    Science.gov (United States)

    Li, Ming; Zhao, Wei

    2012-01-01

    Network calculus is a theory initiated primarily in computer communication networks, especially in the aspect of real-time communications, where min-plus algebra plays a role. Cyber-physical networking systems (CPNSs) are recently developing fast and models in data flows as well as systems in CPNS are, accordingly, greatly desired. Though min-plus algebra may be a promising tool to linearize any node in CPNS as can be seen from its applications to the Internet computing, there are tough problems remaining unsolved in this regard. The identity in min-plus algebra is one problem we shall address. We shall point out the confusions about the conventional identity in the min-plus algebra and present an analytical expression of the asymptotic identity that may not cause confusions.

  2. MSL Chemistry and Mineralogy X-Ray Diffraction X-Ray Fluorescence (CheMin) Instrument

    Science.gov (United States)

    Zimmerman, Wayne; Blake, Dave; Harris, William; Morookian, John Michael; Randall, Dave; Reder, Leonard J.; Sarrazin, Phillipe

    2013-01-01

    This paper provides an overview of the Mars Science Laboratory (MSL) Chemistry and Mineralogy Xray Diffraction (XRD), X-ray Fluorescence (XRF) (CheMin) Instrument, an element of the landed Curiosity rover payload, which landed on Mars in August of 2012. The scientific goal of the MSL mission is to explore and quantitatively assess regions in Gale Crater as a potential habitat for life - past or present. The CheMin instrument will receive Martian rock and soil samples from the MSL Sample Acquisition/Sample Processing and Handling (SA/SPaH) system, and process it utilizing X-Ray spectroscopy methods to determine mineral composition. The Chemin instrument will analyze Martian soil and rocks to enable scientists to investigate geophysical processes occurring on Mars. The CheMin science objectives and proposed surface operations are described along with the CheMin hardware with an emphasis on the system engineering challenges associated with developing such a complex instrument.

  3. New cross section data and review of production routes of medically used $^{110m}$In

    CERN Document Server

    Tárkányi, F; Ditrói, F; Hermanne, A; Baba, M; Mohsena, B M A; Ignatyuk, A V

    2016-01-01

    Evaluation of nuclear data for production routes of $^{110m}$In is in progress in the frame of an IAEA Coordinated Research Project (CRP). New experimental cross section data for the indirect $^{nat}$In(p,x)$^{110}$Sn $\\longrightarrow$ $^{110m}$In and for the direct $^{107}$Ag($\\alpha$,n)$^{110m}$In and $^{109}$Ag($^{3}$He,2n)$^{110m}$In production routes and for the satellite impurity reactions $^{107}$Ag($\\alpha$,xn)$^{110g,109}$In and $^{109}$Ag($^{3}$He,xn)$^{110g,111,109}$In have been measured by using the activation method, stacked foil irradiation technique and gamma-ray spectrometry. Additional data are reported for production of the $^{111}$In diagnostic gamma-emitter via the $^{109}$Ag($\\alpha$,2n)$^{111}$In reaction. The earlier experimental data were critically reviewed in order to prepare recommended data and optimal production parameters for the different routes.

  4. Maxi-Min Language Use A Critical Remark on a Concept by Philippe van Parijs

    Directory of Open Access Journals (Sweden)

    Kruse Jan

    2016-10-01

    Full Text Available Philippe van Parijs explains in Linguistic Justice for Europe and for the World the concept of maxi-min language use as a process of language choice. He suggests that the language chosen as a common language should maximize the minimal competence of a community. Within a multilingual group of people, the chosen language is the language known best by a participant who knows it least. For obvious reasons, only English would qualify for having that status. This article argues that maxi-min is rather a normative concept, not only because the process itself remains empirically unfounded. Moreover, language choice is the result of complex social and psychological structures. As a descriptive process, the maxi-min choice happens in the reality fairly seldom, whereas the max-min use of languages seen as a normative process could be a very effective tool to measure linguistic justice.

  5. Asymptotic Identity in Min-Plus Algebra: A Report on CPNS

    Directory of Open Access Journals (Sweden)

    Ming Li

    2012-01-01

    Full Text Available Network calculus is a theory initiated primarily in computer communication networks, especially in the aspect of real-time communications, where min-plus algebra plays a role. Cyber-physical networking systems (CPNSs are recently developing fast and models in data flows as well as systems in CPNS are, accordingly, greatly desired. Though min-plus algebra may be a promising tool to linearize any node in CPNS as can be seen from its applications to the Internet computing, there are tough problems remaining unsolved in this regard. The identity in min-plus algebra is one problem we shall address. We shall point out the confusions about the conventional identity in the min-plus algebra and present an analytical expression of the asymptotic identity that may not cause confusions.

  6. Berberine Inhibits Intestinal Polyps Growth in Apc (min/+) Mice via Regulation of Macrophage Polarization

    OpenAIRE

    Piao, Meiyu; Cao, Hailong; He, Nana; Yang, Boli; Dong, Wenxiao; Xu, Mengque; Yan, Fang; Zhou, Bing; Wang, Bangmao

    2016-01-01

    Antitumor effect of berberine has been reported in a wide spectrum of cancer, however, the mechanisms of which are not fully understood. The aim of this study was to investigate the hypothesis that berberine suppresses tumorigenesis in the familial adenomatous polyposis (FAP) by regulating the macrophage polarization in Apc (min/+) mouse model. Berberine was given to Apc (min/+) mice for 12 weeks. Primary macrophages were isolated; after berberine treatment, the change in signaling cascade wa...

  7. On the gauge-invariant operator $A^2_{\\min}$ in Euclidean Yang-Mills theories

    CERN Document Server

    Capri, M A L; Guimaraes, M S; Mintz, B W; Palhares, L F; Sorella, S P

    2016-01-01

    We review our recent work on the gauge-invariant non-local dimension-two operator $A^2_{\\rm min}$, whose minimization is defined along the gauge orbit. Albeit non-local, the operator $A^2_{\\rm min}$ can be cast in local form through the introduction of an auxiliary Stueckelberg field. The whole procedure results into a local action which turns out to be renormalizable to all orders.

  8. Min-Min任务调度算法的研究与仿真

    Institute of Scientific and Technical Information of China (English)

    朱雷

    2016-01-01

    文章首先对Min-Min算法进行分析,介绍了算法的思想和执行过程.然后使用GridSim模拟器对算法模拟实现,给出了算法的JAVA实现代码,并统计了Min-Min算法实验结果的完成时间.

  9. Frequency drifts of 3-min oscillations in microwave and EUV emission above sunspots

    OpenAIRE

    Sych, R.; Zaqarashvili, T. V.; Nakariakov, V.M.; Anfinogentov, S. A.; Shibasaki, K; Yan, Y.

    2011-01-01

    We analyse 3-min oscillations of microwave and EUV emission generated at different heights of a sunspot atmosphere, studying the amplitude and frequency modulation of the oscillations, and its relationship with the variation of the spatial structure of the oscillations. High-resolution data obtained with the Nobeyama Radioheliograph, TRACE and SDO/AIA are analysed with the use of the Pixelised Wavelet Filtering and wavelet skeleton techniques. 3-min oscillations in sunspots appear in the form...

  10. Rainfall Prediction using Data-Core Based Fuzzy Min-Max Neural Network for Classification

    OpenAIRE

    Rajendra Palange,; Nishikant Pachpute

    2015-01-01

    This paper proposes the Rainfall Prediction System by using classification technique. The advanced and modified neural network called Data Core Based Fuzzy Min Max Neural Network (DCFMNN) is used for pattern classification. This classification method is applied to predict Rainfall. The neural network called fuzzy min max neural network (FMNN) that creates hyperboxes for classification and predication, has a problem of overlapping neurons that resoled in DCFMNN to give greater accu...

  11. Failure of caffeine to affect metabolism during 60 min submaximal exercise.

    Science.gov (United States)

    Titlow, L W; Ishee, J H; Riggs, C E

    1991-01-01

    Caffeine consumption prior to athletic performance has become commonplace. The usual dosage is approximately 200 mg, a level of caffeine ingestion equivalent to two cups of brewed coffee. This study was designed to examine the effects of a common level of caffeine ingestion, specifically 200 mg, on metabolism during submaximal exercise performance in five males. The subjects performed two 60-min monitored treadmill workouts at 60% maximal heart rate during a 2-week period. The subjects were randomly assigned, double-blind to receive a caffeine or placebo capsule 60 min prior to exercise. Testing was performed in the afternoon following a midnight fast. Venous blood was withdrawn pre-exercise, every 15 min during the workout, and 10 min after recovery. Blood was analysed for free fatty acid, triglycerides, glucose, lactic acid, haemoglobin and haematocrit. The respiratory exchange ratio (R), perceived exertion (RPE) and oxygen uptake were measured every 4 min during exercise. An examination of the data with repeated-measures ANOVA revealed no significant differences between the two groups. Within the limitations of the study, it was concluded that 200 mg caffeine failed to affect metabolism during 60 min submaximal exercise. PMID:1856908

  12. Effects of two kinds of underwear on metabolic heat production during 60 min recovery after 30 min severe exercise in the cold.

    Science.gov (United States)

    Ha, M; Tokura, H; Gotoh, J; Holmér, I

    1998-09-01

    The purpose of this study is to investigate the thermophysiological significance of hydrophilic and hydrophobic properties of underwear materials under the influences of profuse sweating produced during severe exercise in the cold. Two kinds of underwear were used: two layers of cotton underwear with two-piece long-sleeved shirt and full-trousers (C), and two layers of polypropylene underwear with two-piece long-sleeved shirt and full-trousers (P). In addition, the subject put on a two-piece ski suit of 100% polyester including 100% polyester padding. Eight adult females volunteered as subjects in this study. The test was performed in a climatic chamber at an ambient air temperature of 2 degrees C and an air velocity of 0.26 m.s-1. The subject exercised on a cycle ergometer at an intensity of 65% maximal oxygen uptake for 30 min and followed by 60 min recovery. The major findings are summarized as follows: 1) The fall of rectal temperature tended to be greater in P during the recovery. 2) The absolute humidity of innermost layer and middle layer was significantly higher in C than in P during the recovery, but the absolute humidity of middle layer and outermost layer was significantly higher in P than in C during the exercise. 3) Clothing microclimate temperature of innermost at back was significantly higher in C during the exercise and recovery. 4) Metabolic heat production for last 30 min during recovery was significantly higher in P. 5) The degree of skin wettedness sensation and sweating sensation for whole body was significantly higher in P during the exercise. It was concluded that the slower evaporation behavior by absorbing of underwear material in the clothing system has a beneficial influence on thermophysiological responses during severe exercise and its recovery in the cold, although the differences were very small.

  13. Nuclear model calculation and targetry recipe for production of 110mIn

    International Nuclear Information System (INIS)

    110mIn is potentially an important positron emitting that can be used in positron emission tomography. In this work, the excitation functions and production yields of 110Cd(d, 2n), 111Cd(d, 3n), natCd(d, xn), 110Cd(p, n), 111Cd(p, 2n), 112Cd(p, 3n) and natCd(p, xn) reactions to produce the 110mIn were calculated using nuclear model code TALYS and compared with the experimental data. The yield of isomeric state production of 110In was also compared with ground state production ones to reach the optimal energy range of projectile for the high yield production of metastable state. The results indicate that the 110Cd(p, n)110mIn is a high yield reaction with an isomeric ratio (σm/σg) of about 35 within the optimal incident energy range of 15–5 MeV. To make the target, cadmium was electroplated on a copper substrate in varying electroplating conditions such as PH, DC current density, temperature and time. A set of cold tests were also performed on the final sample under several thermal shocks to verify target resistance. The best electroplated cadmium target was irradiated with 15 MeV protons at current of 100 µA for one hour and the production yield of 110mIn and other byproducts were measured. - Highlights: • Optimization of a cadmium electroplating bath to produce high yield 110mIn. • Influence of targetry on isomeric cross section ratio 110mIn/110gIn. • Activity measurement for natCd(p, xn)110m,110g,111g,114mIn reactions

  14. Purification and Crystallization of MinCD Complex from Escherichia coli%大肠杆菌MinCD蛋白复合物纯化方法和晶体筛选

    Institute of Scientific and Technical Information of China (English)

    金瑾; 杨少媛; 朱嘉; 雷振; 郑积敏; 贾宗超

    2015-01-01

    大肠杆菌在细胞分裂时,细胞中部潜在分裂位点的选择受到Min系统(MinC、MinD和MinE蛋白)的精确调控,其中MinC与MinD可以形成复合物以抑制Z分裂环在错误的位置形成.本研究采用基因克隆方法获得minC、minD基因的克隆,并表达得到MinC和MinD的重组蛋白,用亲和层析与凝胶过滤层析对所得蛋白进行纯化,通过minC、minD分别单独转化、表达纯化后混合和minC、minD共转化法两种方法得到MinCD蛋白复合物,并分别对其进行晶体筛选.结果表明,共转化法得到的MinCD复合物纯度较好,且比例约为2∶1,通过晶体筛选初步获得针状蛋白晶体,为MinCD复合物的结构解析提供了实验基础.

  15. Rain rate modeling of 1-min from various integration times in South Korea.

    Science.gov (United States)

    Shrestha, Sujan; Park, Jung-Jin; Choi, Dong-You

    2016-01-01

    Rain plays a major impairment factor for propagation of electromagnetic waves in atmosphere for systems operating at frequencies above 10 GHz. Several effects are noted such as depolarization, scintillation, interference due to scattering and extra attenuation which seems to increase with frequency. To mitigate its effect in satellite communication, knowledge of local rainfall statistics is necessary which act as milestone for design of radio link. Rain attenuation is best visualize by the 1-min rainfall rate statistic but the measurement of this rain rate distribution is rare on a worldwide basis and observation of rain rate are done with longer integration times typically 30 min or more. In this paper, efforts have been made to develop model that can convert rain rate complementary cumulative distribution function to shorter integration times. The average relative error margin of about 5, 14, 43, 71 and 115 % are noted for 5 to 1-, 10 to 1-, 20 to 1, 30 to 1- and 60 to 1-min respectively from ITU-R P.837-6 method which have been analyzed in further section of this article. The empirical natures of conversion methods as such Segal method, Burgueno's method, Chebil and Rahman method and Logarithmic model are studied along with the proposed new model that seems to be applicable in derivation of 1-min rain rate of the South Korea rain rate statistics. International Telecommunication Union-Radio communication Sector (ITU-R) has developed a recommendation ITU-R P.837-6 that enables the user to estimate the local 1-min rainfall rate statistical distribution which is compared with calculated 1-min rain rate distribution from experimental 1-min rainfall accumulation. Unfortunately, ITU-R P.837-6 estimated 1-min values show greater error percentages. In order to get better approximation of local 1-min rain rate estimation, a novel method is proposed and it's efficiency have been compared with rainfall rate statistics obtained from nine different locations in the South

  16. Prosodic Realization of Focus in Bilingual Production of Southern Min and Mandarin.

    Science.gov (United States)

    Chen, Ying; Xu, Yi; Guion-Anderson, Susan

    2014-01-01

    Previously post-focus compression (PFC) - the lowering of fundamental frequency (F0) and intensity of post-focal words to below those of the same words in identical sentences with neutral focus - was found in Beijing Mandarin but not in Taiwan Southern Min and Taiwan Mandarin. This study investigated whether the presence of PFC would vary with age and language use of societal bilinguals of Southern Min and Mandarin. Three groups of bilingual speakers of Quanzhou Southern Min and Mandarin, age around 20, 40 and 60, were examined for their prosodic realization of focus. All the speakers acquired Southern Min first, followed by Mandarin in childhood, but the younger speakers used more Mandarin than the older speakers. Comparisons of duration, intensity and F0 in focused, prefocus and post-focus words indicated that all groups produced Taiwan-like focus, i.e., without PFC, in Southern Min, but the youngest group produced Beijing-like PFC in Mandarin. These findings reveal that increased language experience, such as greater amount of second language (L2) use, correlates with increased ability to produce native-like PFC in L2, suggesting that PFC can be used as an indicator in assessing L2 speech acquisition.

  17. Stochastic switching between multistable oscillation patterns of the Min-system

    CERN Document Server

    Amiranashvili, Artemij; Schwarz, Ulrich S

    2016-01-01

    The spatiotemporal oscillation patterns of the proteins MinD and MinE are used by the bacterium E. coli to sense its own geometry. Strikingly, both computer simulations and experiments have recently shown that for the same geometry of the reaction volume, different oscillation patterns can be stable, with stochastic switching between them. Here we use particle-based Brownian dynamics simulations to predict the relative frequency of different oscillation patterns over a large range of three-dimensional compartment geometries, in excellent agreement with experimental results. Fourier analyses as well as pattern recognition algorithms are used to automatically identify the different oscillation patterns and the switching rates between them. We also identify novel oscillation patterns in three-dimensional compartments with membrane-covered walls and identify a linear relation between the bound Min-protein densities and the volume-to-surface ratio. In general, our work shows how geometry sensing is limited by mult...

  18. MinION nanopore sequencing identifies the position and structure of a bacterial antibiotic resistance island.

    Science.gov (United States)

    Ashton, Philip M; Nair, Satheesh; Dallman, Tim; Rubino, Salvatore; Rabsch, Wolfgang; Mwaigwisya, Solomon; Wain, John; O'Grady, Justin

    2015-03-01

    Short-read, high-throughput sequencing technology cannot identify the chromosomal position of repetitive insertion sequences that typically flank horizontally acquired genes such as bacterial virulence genes and antibiotic resistance genes. The MinION nanopore sequencer can produce long sequencing reads on a device similar in size to a USB memory stick. Here we apply a MinION sequencer to resolve the structure and chromosomal insertion site of a composite antibiotic resistance island in Salmonella Typhi Haplotype 58. Nanopore sequencing data from a single 18-h run was used to create a scaffold for an assembly generated from short-read Illumina data. Our results demonstrate the potential of the MinION device in clinical laboratories to fully characterize the epidemic spread of bacterial pathogens. PMID:25485618

  19. Remote Stimulated Triggering of Quantum Entangled Nuclear Metastable States of 115mIn

    CERN Document Server

    Van Gent, D L

    2004-01-01

    We report experiments in which two indium foils were quantum entangled via photoexcitation of stable 115In to radioactive 115mIn by utilizing Bremsstrahlung gamma photons produced by a Varian Compact Linear Accelerator (CLINAC). After photo-excitation, remote triggering of the "master" foil with low energy gamma photons, yielded stimulated emissions of 336 keV gamma photons from quantum entangled 115mIn in the "slave" foil located up to 1600 m away from the "master" foil. These experiments strongly demonstrate that useful quantum information can be transferred through quantum channels via modulation of quantum noise (accelerated radioactive decay of 115mIn metastable nuclei). Thus, this modality of QE transmission is fundamentally different from optical QE information transfer via quantum entangled space "q-bits" as developed by information theorists for quantum channel information transfer. Additionally, there is no obvious potential for signal degradation with increasing distance nor the problems associated...

  20. Spontaneous initiation, promotion and progression of colorectal cancer in the novel A/J Min/+ mouse.

    Science.gov (United States)

    Sødring, Marianne; Gunnes, Gjermund; Paulsen, Jan Erik

    2016-04-15

    The C57BL/6J multiple intestinal neoplasia (Min/+) mouse is a widely used murine model for familial adenomatous polyposis, a hereditary form of human colorectal cancer. However, it is a questionable model partly because the vast majority of tumors arise in the small intestine, and partly because the fraction of tumors that progress to invasive carcinomas is minuscule. A/J mice are typically more susceptible to carcinogen-induced colorectal cancer than C57BL/6J mice. To investigate whether the novel Min/+ mouse on the A/J genetic background could be a better model for colorectal cancer, we examined the spontaneous intestinal tumorigenesis in 81 A/J Min/+ mice ranging in age from 4 to 60 weeks. The A/J Min/+ mouse exhibited a dramatic increase in number of colonic lesions when compared to what has been reported for the conventional Min/+ mouse; however, an increase in small intestinal lesions did not occur. In addition, this novel mouse model displayed a continual development of colonic lesions highlighted by the transition from early lesions (flat ACF) to tumors over time. In mice older than 40 weeks, 13 colonic (95% CI: 8.7-16.3) and 21 small intestinal (95% CI: 18.6-24.3) tumors were recorded. Notably, a considerable proportion of those lesions progressed to carcinomas in both the colon (21%) and small intestine (51%). These findings more closely reflect aspects of human colorectal carcinogenesis. In conclusion, the novel A/J Min/+ mouse may be a relevant model for initiation, promotion and progression of colorectal cancer.

  1. Effects of Simvastatin on Glucose Metabolism in Mouse MIN6 Cells

    Directory of Open Access Journals (Sweden)

    Jieqiong Zhou

    2014-01-01

    Full Text Available The aim of this study was to investigate the effects of simvastatin on insulin secretion in mouse MIN6 cells and the possible mechanism. MIN6 cells were, respectively, treated with 0 μM, 2 μM, 5 μM, and 10 μM simvastatin for 48 h. Radio immunoassay was performed to measure the effect of simvastatin on insulin secretion in MIN6 cells. Luciferase method was used to examine the content of ATP in MIN6 cells. Real-time PCR and western blotting were performed to measure the mRNA and protein levels of inward rectifier potassium channel 6.2 (Kir6.2, voltage-dependent calcium channel 1.2 (Cav1.2, and glucose transporter-2 (GLUT2, respectively. ATP-sensitive potassium current and L-type calcium current were recorded by whole-cell patch-clamp technique. The results showed that high concentrations of simvastatin (5 μM and 10 μM significantly reduced the synthesis and secretion of insulin compared to control groups in MIN6 cells (P<0.05. ATP content in simvastatin-treated cells was lower than in control cells (P<0.05. Compared with control group, the mRNA and protein expression of Kir6.2 increased with treatment of simvastatin (P<0.05, and mRNA and protein expression of Cav1.2 and GLUT2 decreased in response to simvastatin (P<0.05. Moreover, simvastatin increased the ATP-sensitive potassium current and reduced the L-type calcium current. These results suggest that simvastatin inhibits the synthesis and secretion of insulin through a reduction in saccharometabolism in MIN6 cells.

  2. Empirical Study of FFANN Tolerance to Weight Stuck at Max/Min Fault

    Directory of Open Access Journals (Sweden)

    Amit Prakash Singh

    2010-04-01

    Full Text Available Fault tolerance property of artificial neural networks has been investigated with reference to the hardware model of artificial neural networks. Weight fault is an important link, which causes breakup between two nodes. In this paper three types of weight faults have been explained. Experiments have been performed to demonstrate fault tolerance behavior of feedforward artificial neural network for weight-stuck-MAX/MIN fault. Effect of weight-stuckMAX/MIN fault on trained network has been analyzed in this paper. The obtained results suggest that networks are not fault tolerant to this type of fault.

  3. Päiväkodin liikuntakasvatus lapsen minäkäsityksen ja itsetunnon tukemisessa

    OpenAIRE

    Satoniitty, Sanna

    2010-01-01

    Tämän opinnäytetyön aiheena oli tutkia päiväkodin liikuntakasvatusta sosiaalialan ja sosiaalipedagogiikan näkökulmasta. Tutkimustehtävänä oli selvittää, pyritäänkö päiväkodin liikuntakasvatuksella tukemaan lapsen positiivista minäkäsitystä ja itsetuntoa, sekä millainen liikuntakasvatus tukee lapsen positiivista minäkäsitystä ja itsetuntoa parhaiten. Tutkimus oli luonteeltaan kvalitatiivinen ja se toteutettiin lomakekyselyllä Porin kaupungin päiväkodeille lokakuussa 2009. Tutkimuksen teore...

  4. Research on Algorithm for Generating Min-Area Rectangle Encasing Box for Closed Contour

    Institute of Scientific and Technical Information of China (English)

    Li Qinghua; Dai Guangming; Wang Maocai

    2003-01-01

    In many engineering applications, it is necessary to calculate the min-area encasing box of a circumscription. In this paper, an algorithm for generating the min-area rectangle encasing box, based on revolving angle, is investigated and hence put forward. The algorithm computes the areas of the outer rectangular bounds of a closed contour in different revolving angles θ by dispersing approach where 0<θ<π/2 because of the axial symmetry. It is very simple, straight forward and highly efficient. The complexity of its computing time reaches O(n·k). Practical applications suggest its usefulness and efficiency.

  5. Mission Overview of the Miniature X-ray Solar Spectrometer (MinXSS) CubeSat

    Science.gov (United States)

    Woods, Thomas N.; Caspi, Amir; Chamberlin, Phillip C.; Jones, Andrew; Kohnert, Rick; Li, Xinlin; Mason, James; Moore, Christopher; Palo, Scott; Rouleau, Colden; Solomon, Stanley

    2016-05-01

    The Miniature X-ray Solar Spectrometer (MinXSS) is a 3-Unit (3U) CubeSat to study the energy distribution of solar flare soft X-ray (SXR) emissions of the quiet Sun, active regions, and during flares and to model the solar SXR impact in Earth’s ionosphere, thermosphere, and mesosphere (ITM) using these MinXSS solar measurements. The energy variability in the SXR range can vary by more than a factor of 100, yet we have limited spectral measurements in the SXR to accurately quantify the spectral dependence of this variability. Energy from SXR radiation is deposited mostly in the ionospheric E-region, from ~80 to ~150 km, but the precise altitude is strongly dependent on the SXR spectrum because of the steep slope and structure of the photoionization cross sections of atmospheric gases in this wavelength range. The new MinXSS solar SXR spectra measurements and associated modeling of the solar spectra and Earth’s ITM response will address these outstanding issues. MinXSS includes an Amptek X123 X-ray spectrometer to measure solar irradiance spectra from 0.5 - 30 keV [2.5- 0.04 nm] with a nominal 0.15 keV energy resolution [spectral resolution of 0.7 nm at 2.5 nm and 0.0002 nm at 0.04 nm] and a SXR photometer with similar spectral sensitivity. Both of these SXR instruments had pre-flight calibrations with an accuracy of about 5% at the National Institute for Standard and Technology (NIST) Synchrotron Ultraviolet Radiation Facility (SURF). This presentation will include an overview of the MinXSS CubeSat design and development that involved over 40 graduate students supervised by professors and professionals at the University of Colorado at Boulder. The MinXSS CubeSat was launched in December 2015 to the International Space Station (ISS) and awaits deployment from the ISS in April-May 2016. Assuming MinXSS has been deployed before June, we also intend to present first light observations from MinXSS to highlight solar SXR spectra and SXR variability during May 2016.

  6. AtMIN7 mediated disease resistance to Pseudomonas syringae in Arabidopsis

    Science.gov (United States)

    He, Sheng Yang; Nomura, Kinya

    2011-07-26

    The present invention relates to compositions and methods for enhancing plant defenses against pathogens. More particularly, the invention relates to enhancing plant immunity against bacterial pathogens, wherein AtMIN7 mediated protection is enhanced and/or there is a decrease in activity of an AtMIN7 associated virulence protein such as a Pseudomonas syringae pv. tomato DC3000 HopM1. Reagents of the present invention provide a means of studying cellular trafficking while formulations of the present inventions provide increased pathogen resistance in plants.

  7. Mission Overview of the Miniature X-ray Solar Spectrometer (MinXSS) CubeSat

    Science.gov (United States)

    Woods, Thomas N.; Caspi, Amir; Chamberlin, Phillip C.; Jones, Andrew; Kohnert, Rick; Li, Xinlin; Mason, James; Moore, Christopher; Palo, Scott; Rouleau, Colden; Solomon, Stanley

    2016-05-01

    The Miniature X-ray Solar Spectrometer (MinXSS) is a 3-Unit (3U) CubeSat to study the energy distribution of solar flare soft X-ray (SXR) emissions of the quiet Sun, active regions, and during flares and to model the solar SXR impact in Earth’s ionosphere, thermosphere, and mesosphere (ITM) using these MinXSS solar measurements. The energy variability in the SXR range can vary by more than a factor of 100, yet we have limited spectral measurements in the SXR to accurately quantify the spectral dependence of this variability. Energy from SXR radiation is deposited mostly in the ionospheric E-region, from ~80 to ~150 km, but the precise altitude is strongly dependent on the SXR spectrum because of the steep slope and structure of the photoionization cross sections of atmospheric gases in this wavelength range. The new MinXSS solar SXR spectra measurements and associated modeling of the solar spectra and Earth’s ITM response will address these outstanding issues. MinXSS includes an Amptek X123 X-ray spectrometer to measure solar irradiance spectra from 0.5 – 30 keV [2.5– 0.04 nm] with a nominal 0.15 keV energy resolution [spectral resolution of 0.7 nm at 2.5 nm and 0.0002 nm at 0.04 nm] and a SXR photometer with similar spectral sensitivity. Both of these SXR instruments had pre-flight calibrations with an accuracy of about 5% at the National Institute for Standard and Technology (NIST) Synchrotron Ultraviolet Radiation Facility (SURF). This presentation will include an overview of the MinXSS CubeSat design and development that involved over 40 graduate students supervised by professors and professionals at the University of Colorado at Boulder. The MinXSS CubeSat was launched in December 2015 to the International Space Station (ISS) and awaits deployment from the ISS in April-May 2016. Assuming MinXSS has been deployed before June, we also intend to present first light observations from MinXSS to highlight solar SXR spectra and SXR variability during May 2016.

  8. The effect of soy isoflavones on the development of intestinal neoplasia in Apc(Min) mouse

    DEFF Research Database (Denmark)

    Sørensen, Ilona Kryspin; Kristiansen, Eva; Mortensen, Alicja;

    1998-01-01

    Data from epidemiological studies suggest that isoflavones in soy may have a protective effect on the development of colon cancer in humans. Therefore, we have investigated whether soy isoflavones will inhibit intestinal tumour development in Apc(Min) mice. The mice were fed a Western-type high r...

  9. Numerical Analysis of Strongly Nonlinear Oscillation Systems using He's Max-Min Method

    DEFF Research Database (Denmark)

    Babazadeh, H; Domairry, G; Barari, Amin;

    2011-01-01

    Nonlinear functions are crucial points and terms in engineering problems. Actual and physical problems can be solved by solving and processing such functions. Thus, most scientists and engineers focus on solving these equations. This paper presents a novel method called the max-min method for pre...

  10. Word Prosody in Loanword Phonology: Focus on Japanese Borrowings into Taiwanese Southern Min

    Science.gov (United States)

    Tu, Jung-yueh

    2013-01-01

    This study investigates the adaptation of word prosody in loanword phonology. First, it explicates several influential loanword theories and reviews some representative cases of prosodic adaptation from different languages. Then, it turns to the focus on the prosodic adaptation of Japanese borrowings into Taiwanese Southern Min (TSM or Taiwanese).…

  11. Ja jos minä menisin naapuriin (2/4 F)

    OpenAIRE

    2011-01-01

    Laulun sanat: Ja jos minä menisin naapuriin, sun tuutima lullanlei, kyll' saisin sieltä mä tyttären, sun tuutima lullanlei, ja ois se niin helkkarin komea, sun tuutima lullanlei, sen kotia veisin oriilla, sun tuutima lullanlei!

  12. The Aggregate Homotopy Method for Multi-objective Max-min Problems

    Directory of Open Access Journals (Sweden)

    He Li

    2011-03-01

    Full Text Available Multi-objective programming problem was transformed into a class of simple unsmooth single-objective programming problem by Max-min ways. After smoothing with aggregate function, a new homotopy mapping was constructed. The minimal weak efficient solution of the multi-objective optimization problem was obtained by path tracking. Numerical simulation confirmed the viability of this method.

  13. A Modified MinMax k-Means Algorithm Based on PSO

    Science.gov (United States)

    2016-01-01

    The MinMax k-means algorithm is widely used to tackle the effect of bad initialization by minimizing the maximum intraclustering errors. Two parameters, including the exponent parameter and memory parameter, are involved in the executive process. Since different parameters have different clustering errors, it is crucial to choose appropriate parameters. In the original algorithm, a practical framework is given. Such framework extends the MinMax k-means to automatically adapt the exponent parameter to the data set. It has been believed that if the maximum exponent parameter has been set, then the programme can reach the lowest intraclustering errors. However, our experiments show that this is not always correct. In this paper, we modified the MinMax k-means algorithm by PSO to determine the proper values of parameters which can subject the algorithm to attain the lowest clustering errors. The proposed clustering method is tested on some favorite data sets in several different initial situations and is compared to the k-means algorithm and the original MinMax k-means algorithm. The experimental results indicate that our proposed algorithm can reach the lowest clustering errors automatically.

  14. Optimal value functions of generalized semi-infinite min-max programming on a noncompact set

    Institute of Scientific and Technical Information of China (English)

    WANG; Changyu; YANG; Xiaoqi; YANG; Xinmin

    2005-01-01

    In this paper, we study optimal value functions of generalized semi-infinite min-max programming problems on a noncompact set. Directional derivatives and subdifferential characterizations of optimal value functions are given. Using these properties,we establish first order optimality conditions for unconstrained generalized semi-infinite programming problems.

  15. Separation of sup(115m)In from mother 115Cd

    International Nuclear Information System (INIS)

    The methods of the accelerated isolation of the metallic sup(115m)In from the mother solution of 115Cd were worked out. The sample was dissolved in the concentrated HCl with the presence of H2O2. After the injection of 5 mg (recalculated for the metallic In) of the carrier, the solution was evaporated dry, the remainder was dissolved in 2n HCl. The obtained solution was lead through an ion-exchange column (9 mm in diameter and with the 250 mm height of the layer with the anionite Dowex 2x8 (50-100 mesh). The sup(115m)In was eluated by 0.15n HCl, and 115Cd - by 1.5n HCl. Radiochemical purity of the sup(115m)In was not less than 99.99%. The isolation of the sup(115m)In from the eluent (alkalined up to ph=2.3) was carried out electrochemically during approximately 1 hour on the platinum cathode at high (400 mA/cm2) cathode density of current

  16. Symmetry and scale orient Min protein patterns in shaped bacterial sculptures

    Science.gov (United States)

    Wu, Fabai; van Schie, Bas G. C.; Keymer, Juan E.; Dekker, Cees

    2015-08-01

    The boundary of a cell defines the shape and scale of its subcellular organization. However, the effects of the cell's spatial boundaries as well as the geometry sensing and scale adaptation of intracellular molecular networks remain largely unexplored. Here, we show that living bacterial cells can be ‘sculpted’ into defined shapes, such as squares and rectangles, which are used to explore the spatial adaptation of Min proteins that oscillate pole-to-pole in rod-shaped Escherichia coli to assist cell division. In a wide geometric parameter space, ranging from 2 × 1 × 1 to 11 × 6 × 1 μm3, Min proteins exhibit versatile oscillation patterns, sustaining rotational, longitudinal, diagonal, stripe and even transversal modes. These patterns are found to directly capture the symmetry and scale of the cell boundary, and the Min concentration gradients scale with the cell size within a characteristic length range of 3-6 μm. Numerical simulations reveal that local microscopic Turing kinetics of Min proteins can yield global symmetry selection, gradient scaling and an adaptive range, when and only when facilitated by the three-dimensional confinement of the cell boundary. These findings cannot be explained by previous geometry-sensing models based on the longest distance, membrane area or curvature, and reveal that spatial boundaries can facilitate simple molecular interactions to result in far more versatile functions than previously understood.

  17. A hypothesis to explain division site selection in Escherichia coli by combining nucleoid occlusion and Min.

    Science.gov (United States)

    Norris, Vic; Woldringh, Conrad; Mileykovskaya, Eugenia

    2004-03-12

    The positioning of the site of cell division in Escherichia coli results, it is generally believed, from the operation of nucleoid occlusion in combination with the Min system. Nucleoid occlusion prevents division over the nucleoids and directs it by default to the mid-cell region between segregating nucleoids or to polar regions while the Min system prevents division in polar regions. Unresolved questions include how these systems interact to control the earliest known event in division, the assembly at the membrane of the tubulin-like protein, FtsZ, and, more importantly, what exactly constitutes a division site. Evidence exists that (1) the coupled transcription, translation and insertion of proteins into membrane (transertion), can structure the cytoplasmic membrane into phospholipid domains, (2) the MinD protein can convert vesicles into tubes and (3) a variety of membranous structures can be observed at mid-cell. These data support a model in which transertion from the segregating daughter chromosomes leads to the formation of a distinct proteolipid domain between them at mid-cell; the composition of this domain allows phospholipid tubes to extend like fingers into the cytoplasm; these tubes then become the substrate for the dynamic assembly and disassembly of FtsZ which converts them into the invaginating fold responsible for division; the Min system inhibits division at unwanted sites and times by removing these tubes especially at the cell poles. PMID:15013745

  18. Development of a colour scale for colour evaluation of beef carcasses at 60 min post mortem

    NARCIS (Netherlands)

    Hulsegge, I.; Merkus, G.S.M.

    1999-01-01

    The pectoralis profundus muscles of 200 selected beef carcasses were measured to develop a standard colour scale for evaluating beef carcasses at the time of classification (approximately 60 min post mortem). Five lightness (L*) values were chosen ranging from 22 to 42 with intervals of five L* unit

  19. On Graphs of the Cone Decompositions for the Min-Cut and Max-Cut Problems

    Directory of Open Access Journals (Sweden)

    Vladimir Bondarenko

    2016-01-01

    Full Text Available We consider maximum and minimum cut problems with nonnegative weights of edges. We define the graphs of the cone decompositions and find a linear clique number for the min-cut problem and a superpolynomial clique number for the max-cut problem. These values characterize the time complexity in a broad class of algorithms based on linear comparisons.

  20. A Modified MinMax k-Means Algorithm Based on PSO

    Directory of Open Access Journals (Sweden)

    Xiaoyan Wang

    2016-01-01

    Full Text Available The MinMax k-means algorithm is widely used to tackle the effect of bad initialization by minimizing the maximum intraclustering errors. Two parameters, including the exponent parameter and memory parameter, are involved in the executive process. Since different parameters have different clustering errors, it is crucial to choose appropriate parameters. In the original algorithm, a practical framework is given. Such framework extends the MinMax k-means to automatically adapt the exponent parameter to the data set. It has been believed that if the maximum exponent parameter has been set, then the programme can reach the lowest intraclustering errors. However, our experiments show that this is not always correct. In this paper, we modified the MinMax k-means algorithm by PSO to determine the proper values of parameters which can subject the algorithm to attain the lowest clustering errors. The proposed clustering method is tested on some favorite data sets in several different initial situations and is compared to the k-means algorithm and the original MinMax k-means algorithm. The experimental results indicate that our proposed algorithm can reach the lowest clustering errors automatically.

  1. Determinants of poor 6-min walking distance in patients with COPD: the ECLIPSE cohort

    DEFF Research Database (Denmark)

    Spruit, Martijn A; Watkins, Michael L; Edwards, Lisa D;

    2010-01-01

    identify clinical determinants of a poor 6-min walking distance (<350 m) in patients with COPD. METHODS: 1795 individuals with a diagnosis of COPD underwent spirometry; bio-electrical impedance analysis; low-dose computed tomography scans of the chest; 6MWT; ATS-DLD co-morbidity questionnaire; Center for...

  2. Visualization of the specific interaction of sulfonylurea-incorporated polymer with insulinoma cell line MIN6.

    Science.gov (United States)

    Park, Keun-Hong; Akaike, Toshihiro

    2004-02-01

    A derivative of sulfonylurea (SU) that mimics glibenclamide in chemical structure was synthesized and incorporated into a water-soluble polymeric backbone as a biospecific polymer for stimulating insulin secretion. In this study, a backbone polymer fluorescence-labeled with rodamine-B isothiocyanate was found to be strongly adsorbed onto MIN6 cells, probably due to its specific interaction mediated by SU receptors on the cell membrane. The intensity of fluorescence on the cells was significantly increased by increasing the incubation time and polymer concentration. To verify the specific interaction between the SU (K(+) channel closer)-incorporated copolymer and MIN6 cells, the cells were pretreated with diazoxide, an agonist of the ATP-sensitive K(+) channel (K(+) channel opener), before adding the polymer to the cell culture medium. This treatment suppressed the interaction between SU and MIN6 cells. A confocal laser microscopic study confirmed this effect. The results of this study provide evidence that SU-incorporated copolymer stimulates insulin secretion through the specific interactions of SU moieties in the polymer with MIN6 cells.

  3. Curcumin suppresses intestinal polyps in APC Min mice fed a high fat diet

    Directory of Open Access Journals (Sweden)

    Christina Pettan-Brewer

    2011-06-01

    Full Text Available Colorectal cancer (CRC is a leading cause of cancer deaths in the United States. Various risk factors have been associated with CRC including increasing age and diet. Epidemiological and experimental studies have implicated a diet high in fat as an important risk factor for colon cancer. High fat diets can promote obesity resulting in insulin resistance and inflammation and the development of oxidative stress, increased cell proliferation, and suppression of apoptosis. Because of the high consumption of dietary fats, especially saturated fats, by Western countries, it is of interest to see if non-nutrient food factors might be effective in preventing or delaying CRC in the presence of high saturated fat intake. Curcumin (Curcuma longa, the main yellow pigment in turmeric, was selected to test because of its reported anti-tumor activity. APC Min mice, which develop intestinal polyps and have many molecular features of CRC, were fed a diet containing 35% pork fat, 33% sucrose, and a protein and vitamin mineral mixture (HFD with or without 0.5% curcumin. These cohorts were compared to APC Min mice receiving standard rodent chow (RC with 8% fat. APC Min mice fed the HFD for 3 months had a 23% increase in total number of polyps compared to APC Min mice on RC. Curcumin was able to significantly reverse the accelerated polyp development associated with the HFD suggesting it may be effective clinically in helping prevent colon cancer even when ingesting high amounts of fatty foods. The anti-tumor effect of curcumin was shown to be associated with enhanced apoptosis and increased efficiency of DNA repair. Since curcumin prevented the gain in body weight seen in APC Min mice ingesting the HFD, modulation of energy metabolism may also be a factor.

  4. Intestinal tumor suppression in ApcMin/+ mice by prostaglandin D2 receptor PTGDR

    International Nuclear Information System (INIS)

    Our earlier work showed that knockout of hematopoietic prostaglandin D synthase (HPGDS, an enzyme that produces prostaglandin D2) caused more adenomas in ApcMin/+ mice. Conversely, highly expressed transgenic HPGDS allowed fewer tumors. Prostaglandin D2 (PGD2) binds to the prostaglandin D2 receptor known as PTGDR (or DP1). PGD2 metabolites bind to peroxisome proliferator-activated receptor γ (PPARG). We hypothesized that Ptgdr or Pparg knockouts may raise numbers of tumors, if these receptors take part in tumor suppression by PGD2. To assess, we produced ApcMin/+ mice with and without Ptgdr knockouts (147 mice). In separate experiments, we produced ApcMin/+ mice expressing transgenic lipocalin-type prostaglandin D synthase (PTGDS), with and without heterozygous Pparg knockouts (104 mice). Homozygous Ptgdr knockouts raised total numbers of tumors by 30–40% at 6 and 14 weeks. Colon tumors were not affected. Heterozygous Pparg knockouts alone did not affect tumor numbers in ApcMin/+ mice. As mentioned above, our Pparg knockout assessment also included mice with highly expressed PTGDS transgenes. ApcMin/+ mice with transgenic PTGDS had fewer large adenomas (63% of control) and lower levels of v-myc avian myelocytomatosis viral oncogene homolog (MYC) mRNA in the colon. Heterozygous Pparg knockouts appeared to blunt the tumor-suppressing effect of transgenic PTGDS. However, tumor suppression by PGD2 was more clearly mediated by receptor PTGDR in our experiments. The suppression mechanism did not appear to involve changes in microvessel density or slower proliferation of tumor cells. The data support a role for PGD2 signals acting through PTGDR in suppression of intestinal tumors

  5. Structural and functional studies of MinD ATPase: implications for the molecular recognition of the bacterial cell division apparatus

    OpenAIRE

    Hayashi, Ikuko; Oyama, Takuji; Morikawa, Kosuke

    2001-01-01

    Proper placement of the bacterial cell division site requires the site-specific inactivation of other potential division sites. In Escherichia coli, selection of the correct mid-cell site is mediated by the MinC, MinD and MinE proteins. To clarify the functional role of the bacterial cell division inhibitor MinD, which is a membrane-associated ATPase that works as an activator of MinC, we determined the crystal structure of a Pyrococcus furiosus MinD homologue complexed with a substrate analo...

  6. Role of P-selectin in intestinal tumorigenesis in ApcMin/+ mice%P-选择素对ApcMin/+小鼠肠道肿瘤的作用

    Institute of Scientific and Technical Information of China (English)

    郭四美; 亓翠玲; 叶杰; 周秦; 王丽京

    2012-01-01

    ADM: To investigate the role of P ?selectin in intestinal tumorigenesis in Ape Min/+ mice ( C57BL/ 6J -ApcMin/J ). METHODS: Female P - selectin knockout mice ( B6. 129S7 - Selptml Bay/J, that was P - selectin-/- ) were mated with male ApcMin/+ mice. The offspring was genotyped for Min+/- and P -selectin null mutantions, which were ApcMin/+ P - selectin-/- ~ mice. The tumor number and gross tumor volume in the small and large intestines of the ApcMin/ + P - selectin -/- mice and ApcMin/ + mice were determined. RESULTS: P - selectin deficiency in ApcMin/ + mice resulted in significant decreases in the tumor number and gross tumor volume in the small intestine and total intestine. CONCLUSION : Deletion of P - selectin significantly inhibits the tumorigenesis in mouse intestines. In addition, the results also suggest that P - selectin may be a marker for colon cancer.%目的:研究P-选择素(P-selectin)在ApcMin/+小鼠肠道肿瘤中的作用.方法:采用P-selectin基因缺失的基因工程小鼠和肠道肿瘤模型ApcMin/+小鼠杂交,计数ApcMin/+小鼠与ApcMin/+ P-selectin-/-杂交小鼠小肠及大肠肿瘤的数目,并测量其肿瘤体积,研究P-selectin对ApcMin/+小鼠肠道肿瘤的作用.结果:与ApcMin/+小鼠相比,ApcMin/+ P-selectin-/-杂交小鼠在9周龄时肠道肿瘤数目与总负荷明显减少.结论:P-selectin缺失能够显著抑制ApcMin/+小鼠肠道肿瘤的生长.

  7. Chemopreventive Effects of RXR-Selective Rexinoid Bexarotene on Intestinal Neoplasia of ApcMin/+ Mice

    OpenAIRE

    Janakiram, Naveena B; Altaf Mohammed; Li Qian; Chang-In Choi; Steele, Vernon E.; Rao, Chinthalapally V.

    2012-01-01

    Retinoid X receptor (RXR) has been implicated in several neoplastic diseases. Previously, we have shown that RXR-α is downregulated in human and rodent colonic tumors, suggesting a potential target for colon cancer prevention (http://www.cancer.org/Cancer/ColonandRectumCancer/DetailedGuide/colorectal-cancer-key-statistics). Experiments were designed to assess the chemopreventive efficacy of the selective RXR agonist bexarotene for the suppression of intestinal tumorigenesis in ApcMin/+ mice. ...

  8. The effect of exercise on IL-6-induced cachexia in the Apc Min /+ mouse

    OpenAIRE

    Puppa, Melissa J.; White, James P.; Kandy T Velázquez; Baltgalvis, Kristen A.; Sato, Shuichi; Baynes, John W.; Carson, James A.

    2011-01-01

    Background Cachexia involves unintentional body weight loss including diminished muscle and adipose tissue mass and is associated with an underlying disease. Systemic overexpression of IL-6 accelerates cachexia in the ApcMin/+ mouse, but does not induce wasting in control C57BL/6 mice. With many chronic diseases, chronic inflammation and metabolic dysfunction can be improved with moderate exercise. A direct effect of regular moderate exercise on the prevention of IL-6-induced cachexia in the ...

  9. Comprehensive Evaluation on Ecological Security in the Upper Min River Basin

    OpenAIRE

    Shang-chun, Xie; Hui, Liu; Ze-hong, Zhang

    2010-01-01

    Related literatures about ecological fragile is reviewed; the current status of ecological environment in the upper Min River basin is summarized. Equations for calculating the ecological footprint and ecological carrying capacity, as well as the standards of evaluating the status of ecological security are introduced. When ecological carrying capacity is greater than ecological footprint, ecosystem in this region is in safe state, and vice verse. According to the research data about five cou...

  10. Caffeine, but not bicarbonate, improves 6 min maximal performance in elite rowers.

    Science.gov (United States)

    Christensen, Peter M; Petersen, Mads H; Friis, Signe N; Bangsbo, Jens

    2014-09-01

    This study examined the ergogenic effects in a 6 min maximal performance test (PT) on 12 elite rowers: 6 open-weight (mean ± SD; 25 ± 1 years, and 92 ± 3 kg) and 6 light-weight (25 ± 3 years, and 73 ± 6 kg), following supplementation with caffeine (CAF), sodium bicarbonate (SB), and the combination of both, in a double-blind randomized placebo (PLA) controlled design. PT was executed on 4 occasions, on separate days within a week, and in a non-fasted state, with standardized training being performed the day before PT. Protocols were as follows: (i) CAF, 3 mg/kg, 45 min prior to PT + calcium as SB-PLA; (ii) SB, 0.3 g/kg, 75 min prior to PT + dextrose as CAF-PLA; (iii) CAF + SB; and (iv) PLA; CAF-PLA + SB-PLA. The total distance in the CAF (1878 ± 97 m) and CAF + SB (1877 ± 97 m) was longer than in the PLA (1865 ± 104 m; P PLA (393 ± 61 W; P PLA in the last half (4-6 min) of PT. Trials with CAF were more effective in light-weight rowers (1.0% ± 0.8% improvement in distance; P 0.05). No difference between interventions was observed for readiness and stomach comfort before PT and perceived exertion during PT. This study demonstrates that caffeine ingestion does improve performance in elite rowing. In contrast sodium bicarbonate does not appear to be ergogenic, but it does not abolish the ergogenic effect of caffeine. PMID:24999004

  11. Discovering Non-Redundant Association Rules using MinMax Approximation Rules

    Directory of Open Access Journals (Sweden)

    R. Vijaya Prakash

    2012-12-01

    Full Text Available Frequent pattern mining is an important area of data mining used to generate the Association Rules. The extracted Frequent Patterns quality is a big concern, as it generates huge sets of rules and many of them are redundant. Mining Non-Redundant Frequent patterns is a big concern in the area of Association rule mining. In this paper we proposed a method to eliminate the redundant Frequent patterns using MinMax rule approach, to generate the quality Association Rules.

  12. Reliability of the 5-min psychomotor vigilance task in a primary school classroom setting.

    Science.gov (United States)

    Wilson, Andrew; Dollman, James; Lushington, Kurt; Olds, Timothy

    2010-08-01

    This study evaluated the reliability of the 5-min psychomotor vigilance task (PVT) in a single-sex Australian primary school. Seventy-five male students (mean age = 11.82 years, SD = 1.12) completed two 5-min PVTs using a Palm personal digital assistant (PDA) in (1) an isolated setting and (2) a classroom setting. Of this group of students, a subsample of 37 students completed a test-retest reliability trial within the classroom setting. Using a mixed-model analysis, there was no significant difference in the mean response time (RT) or number of lapses (RTs >or= 500 msec) between the isolated and the classroom setting. There was, however, an order effect for the number of lapses in the isolated setting, with the number of lapses being greater if the isolated test was conducted second. Test-retest intraclass correlation coefficients (ICCs) in the classroom setting indicated moderate to high reliability (mean RT = .84, lapses = .59). Bland-Altman analysis showed no systematic difference between the two settings. Findings suggest that the 5-min PDA PVT is a reliable measure of sustained attention in the classroom setting in this sample of primary-aged schoolchildren. The results provide further evidence for the versatility of this measuring device for larger interventions outside the laboratory. PMID:20805597

  13. Character recognition using min-max classifiers designed via an LMS algorithm

    Science.gov (United States)

    Yang, Ping-Fai; Maragos, Petros

    1992-11-01

    In this paper we propose a Least Mean Square (LMS) algorithm for the practical training of the class of min-max classifiers. These are lattice-theoretic generalization of Boolean functions and are also related to feed-forward neural networks and morphological signal operators. We applied the LMS algorithm to the problem of handwritten character recognition. The database consists of segmented and cleaned digits. Features that were extracted from the digits include Fourier descriptors and morphological shape-size histograms. Experimental results using the LMS algorithm for handwritten character recognition are promising. In our initial experimentation, we applied the min-max classifier to binary classification of '0' and '1' digits. By preprocessing the feature vectors, we were able to achieve an error rate of 1.75% for a training set of size 1200 (600 of each digit); and an error rate of 4.5% on a test set of size 400 (200 of each). These figures are comparable to those obtained by 2-layer neural nets trained using back propagation. The major advantage of min-max classifiers compared to neural networks is their simplicity and the faster convergence of their training algorithm.

  14. The food processing contaminant glyoxal promotes tumour growth in the multiple intestinal neoplasia (Min) mouse model.

    Science.gov (United States)

    Svendsen, Camilla; Høie, Anja Hortemo; Alexander, Jan; Murkovic, Michael; Husøy, Trine

    2016-08-01

    Glyoxal is formed endogenously and at a higher rate in the case of hyperglycemia. Glyoxal is also a food processing contaminant and has been shown to be mutagenic and genotoxic in vitro. The tumourigenic potential of glyoxal was investigated using the multiple intestinal neoplasia (Min) mouse model, which spontaneously develops intestinal tumours and is susceptible to intestinal carcinogens. C57BL/6J females were mated with Min males. Four days after mating and throughout gestation and lactation, the pregnant dams were exposed to glyoxal through drinking water (0.0125%, 0.025%, 0.05%, 0.1%) or regular tap water. Female and male offspring were housed separately from PND21 and continued with the same treatment. One group were only exposed to 0.1% glyoxal from postnatal day (PND) 21. There was no difference in the number of intestinal tumours between control and treatment groups. However, exposure to 0.1% glyoxal starting in utero and at PND21 caused a significant increase in tumour size in the small intestine for male and female mice in comparison with respective control groups. This study suggests that glyoxal has tumour growth promoting properties in the small intestine in Min mice. PMID:27288931

  15. Constrained Balancing of Two Industrial Rotor Systems: Least Squares and Min-Max Approaches

    Directory of Open Access Journals (Sweden)

    Bin Huang

    2009-01-01

    Full Text Available Rotor vibrations caused by rotor mass unbalance distributions are a major source of maintenance problems in high-speed rotating machinery. Minimizing this vibration by balancing under practical constraints is quite important to industry. This paper considers balancing of two large industrial rotor systems by constrained least squares and min-max balancing methods. In current industrial practice, the weighted least squares method has been utilized to minimize rotor vibrations for many years. One of its disadvantages is that it cannot guarantee that the maximum value of vibration is below a specified value. To achieve better balancing performance, the min-max balancing method utilizing the Second Order Cone Programming (SOCP with the maximum correction weight constraint, the maximum residual response constraint as well as the weight splitting constraint has been utilized for effective balancing. The min-max balancing method can guarantee a maximum residual vibration value below an optimum value and is shown by simulation to significantly outperform the weighted least squares method.

  16. Polynomial Time Algorithms for Branching Markov Decision Processes and Probabilistic Min(Max) Polynomial Bellman Equations

    CERN Document Server

    Etessami, Kousha; Yannakakis, Mihalis

    2012-01-01

    We show that one can approximate the least fixed point solution for a multivariate system of monotone probabilistic max(min) polynomial equations, referred to as maxPPSs (and minPPSs, respectively), in time polynomial in both the encoding size of the system of equations and in log(1/epsilon), where epsilon > 0 is the desired additive error bound of the solution. (The model of computation is the standard Turing machine model.) We establish this result using a generalization of Newton's method which applies to maxPPSs and minPPSs, even though the underlying functions are only piecewise-differentiable. This generalizes our recent work which provided a P-time algorithm for purely probabilistic PPSs. These equations form the Bellman optimality equations for several important classes of infinite-state Markov Decision Processes (MDPs). Thus, as a corollary, we obtain the first polynomial time algorithms for computing to within arbitrary desired precision the optimal value vector for several classes of infinite-state...

  17. Sensor scheduling in mobile robots using incomplete information via Min-Conflict with Happiness.

    Science.gov (United States)

    Gage, Aaron; Murphy, Robin Roberson

    2004-02-01

    This paper develops and applies a variant of the Min-Conflict algorithm to the problem of sensor allocation with incomplete information for mobile robots. A categorization of the types of contention over sensing resources is provided, as well as a taxonomy of available information for the sensor scheduling task. The Min-Conflict with Happiness (MCH) heuristic algorithm, which performs sensor scheduling for situations in which no information is known about future assignments, is then described. The primary contribution of this modification to Min-Conflict is that it permits the optimization of sensor certainty over the set of all active behaviors, thereby producing the best sensing state for the robot at any given time. Data are taken from simulation experiments and runs from a pair of Nomad200 robots using the SFX hybrid deliberative/reactive architecture. Results from these experiments demonstrate that MCH is able to satisfy more sensor assignments (up to 142%) and maintain a higher overall utility of sensing than greedy or random assignments (a 7-24% increase), even in the presence of sensor failures. In addition, MCH supports behavioral sensor fusion allocations. The practical advantages of MCH include fast, dynamic repair of broken schedules allowing it to be used on computationally constrained systems, compatibility with the dominant hybrid robot architectural style, and least-disturbance of prior assignments minimizing interruptions to reactive behaviors.

  18. Intestinal Peyer’s patches prevent tumorigenesis in Apc Min/+ mice

    OpenAIRE

    Fujimoto, Kyoko; Fujii, Gen; Sakurai, Hitomi; Yoshitome, Hiroko; Mutoh, Michihiro; Wada, Morimasa

    2014-01-01

    Peyer’s patches are nodules that play a central role in intestinal immunity. Few studies demonstrate the relationship between the number of Peyer’s patches and intestinal polyps. Here we identify a statistically significant inverse correlation between the quantity of Peyer’s patches and of the development of intestinal polyps in Apc Min/+ mice, which are a useful model to clarify the role of Peyer’s patches in intestinal tumorigenesis. Using this model, we increased the number of Peyer’s patc...

  19. PMMA mPOF Bragg gratings written in less than 10 min

    DEFF Research Database (Denmark)

    Bundalo, Ivan-Lazar; Nielsen, Kristian; Markos, Christos;

    2014-01-01

    Fiber Bragg grating (FBG) writing in PMMA microstructured Polymer Optical Fibers (mPOFs) using the UV Phase Mask technique is a time consuming process requiring about 40 minutes to inscribe a grating in an undoped fiber. Here we demonstrate the FBG inscription with the writing times shorter than 10...... min. By careful alligning and increasing the beam intensity in the core of the fiber, writing times as short as 6 minutes and 50 second were achieved. The FBGs were written in a 125 μm PMMA mPOF having 3-rings of holes, the reflection peaks were centred at 632.6 nm and have a reflectivity as high...

  20. Quicksort, largest bucket, and min-wise hashing with limited independence

    DEFF Research Database (Denmark)

    Knudsen, Mathias Bæk Tejs; Stöckel, Morten

    2015-01-01

    to be k-independent if every variable is uniform and every size k subset is independent. In this paper we consider three classic algorithms under limited independence. Besides the theoretical interest in removing the unrealistic assumption of full independence, the work is motivated by lower independence...... being more practical. We provide new bounds for randomized quicksort, min-wise hashing and largest bucket size under limited independence. Our results can be summarized as follows. Randomized Quicksort. When pivot elements are computed using a 5-independent hash function, Karloff and Raghavan, J.ACM’93...

  1. Performing Mineral Hydration Experiments in the CheMin Diffractometer on Mars

    Science.gov (United States)

    Vaniman, D. T.; Yen, A. S.; Rampe, E. B.; Blake, D. F.; Chipera, S. J.; Morookian, J. M.; Ming, D. W.; Bristow, T. F.; Morris, R. V.; Geller, R.; Morrison, S. M.; Grotzinger, J. P.; Archilles, C. N.; Downs, R. T.; Rapin, W.; Rice, M.; Bell, J. F., III; Sarrazin, P.; Farmer, J. D.

    2016-01-01

    Laboratory work is the cornerstone of experimental planetary geochemistry, mineralogy, and petrology, but much is to be gained by "experiments" while on a planet surface. Earth-bound experiments are often limited in ability to control multiple conditions relevant to planetary bodies (e.g. cycles in temperature and vapor pressure of water), but observations on-planet provide a unique opportunity where conditions are native to the planet and those affected by sampling and analysis can be constrained. The CheMin XRD instrument on Mars Science Laboratory has been able to test mineral hydration in samples held for up to 300 Mars days (sols). Clay minerals sampled at Yellowknife Bay early in the mission had both collapsed (10 Å) and expanded (13.2 Å) basal spacing. Collapsed interlayers were expected, but larger spacing was not; it was uncertain whether larger basal spacing would collapse on prolonged exposure to warmer conditions inside CheMin. Observation over several hundred sols showed no collapse, with the conclusion that expanded interlayer spacing was due to partial intercalation by metal-hydroxyl groups that resist dehydration. More recently, a sample of the Murray Formation, Oudam, provided the first XRD detection of gypsum and a chance to observe gypsum stability. Laboratory work suggests gypsum should be stable at Mars surface conditions, and indeed gypsum has been observed from orbit at higher latitudes and in thick veins at Yellowknife Bay by Mastcam reflectance spectra. Laboratory experiments have shown that on dehydration the gypsum would not become X-ray amorphous but would rather transform to a water-deficient bassanite structure. Over a period of 37 sols, it was observed that the Oudam sample in CheMin transformed from an assemblage of gypsum+anhydrite, to gypsum+bassanite+anhydrite, and finally to bassanite+anhydrite. Mg-sulfates were also anticipated but have not been observed in CheMin despite chemical evidence for their presence. Unlike gypsum

  2. Min-Max Theorems Related to Geometric Representations of Graphs and their SDPs

    CERN Document Server

    Silva, Marcel K Carli

    2010-01-01

    We prove a simple nonlinear identity relating the Lov{\\'a}sz theta number of a graph to its smallest radius hypersphere embedding where each edge has unit length. We use this identity and its generalizations to establish min-max theorems and to translate results related to one of the graph invariants above to the other. Classical concepts in tensegrity theory allow good interpretations of the dual SDP for the problem of finding an optimal hypersphere embedding as above. We generate a spectrum of structured SDPs on which extensions of such interpretations are possible.

  3. A weighted min-max model for balanced freight train routing problem with fuzzy information

    Science.gov (United States)

    Yang, Lixing; Gao, Ziyou; Li, Xiang; Li, Keping

    2011-12-01

    A multi-objective freight train routing problem with fuzzy information is investigated in this article. To handle the fuzziness in the railway transportation system, the measure ℳλ (i.e. the convex combination of a possibility measure and a necessity measure) is first introduced. Then, a min-max chance-constrained programming model is constructed to obtain optimal train routing plans. In order to solve the model, a potential route algorithm, fuzzy simulation and tabu search algorithm are integrated as a hybrid algorithm. Finally, some numerical experiments are performed to show the applications of the model and the algorithm.

  4. Auto-Stabilisation et Confinement de Fautes Malicieuses : Optimalit\\'e du Protocole min+1

    CERN Document Server

    Dubois, Swan; Tixeuil, Sébastien

    2011-01-01

    A self-stabilizing is naturally resilient to transients faults (that is, faults of finite duration). Recently, a new class of protocol appears. These protocols are self-stabilizing and are moreover resilient to a limited number of permanent faults. In this article, we interest in self-stabilizing protocols that tolerate very hard permanent faults: Byzantine faults. We introduce two new scheme of Byzantine containment in self-stabilizing systems. We show that, for the problem of BFS spanning tree construction, the well known self-stabilizing protocol min+1 provides without significant modification the best Byzantine containment with respect to these new schemes.

  5. Antrodia Camphorata increases insulin secretion and protects from apoptosis in MIN6 cells

    Directory of Open Access Journals (Sweden)

    Chi Teng eVong

    2016-03-01

    Full Text Available Antrodia camphorata (A. camphorata is a Taiwanese-specific fungus which has been used clinically to treat hypertension, immune- and liver-related diseases and cancer, however it has never been studied in Type II Diabetes (T2DM. Hyperglycaemia in T2DM causes endoplasmic reticulum (ER stress, leading to β-cell dysfunction. During chronic ER stress, misfolded proteins accumulate and initiate β-cell apoptosis. Moreover, β-cell dysfunction leads to defect in insulin secretion, which is the key process in the development and progression of T2DM. Therefore, the aim of the present study was to examine the effects of A. camphorata on insulin secretion and ER stress-induced apoptosis in a mouse β-cell line, MIN6, and their underlying mechanisms. We demonstrated that the ethanolic extract of A. camphorata increased glucose-induced insulin secretion dose-dependently through peroxisome proliferator-activated receptor-γ (PPAR-γ pathway, and upregulated genes that were involved in insulin secretion, including PPAR-γ, glucose transporter-2 (GLUT-2 and glucokinase. Furthermore, A. camphorata slightly increased cell proliferation, as well as protected from ER stress-induced apoptosis in MIN6 cells. In conclusion, this study provided evidences that A. camphorata might have anti-diabetic effects and could be a novel drug for T2DM.

  6. Liang Shu-min and Buddhism%梁漱溟与佛学

    Institute of Scientific and Technical Information of China (English)

    张文儒

    2001-01-01

    Liang Shu-min was a celebrated figure in modern Chine se history,famous for his life principle “upright and independent, honest and frank". Speaking from his academic thought, he considered the essence of his thought was Confucianism and Buddhism. From the reasons why he believed in Buddhism, his contributions to Buddhism in India and his comparisons between the Buddhism and Confucianism, one can see that Liang Shu-min's Buddhism thought was not only an ideology he accepted but also the essential motive that he practiced all his life.%梁漱溟是中国现代史上一位著名人物。他以“特立独行、一代直声”饮誉后世。在学术思想上,他自认思想的根本是儒家和佛家。从他为什么会信佛和他对印度佛学研究的贡献及对于儒佛异同的比较等几个方面,可以看出梁漱溟佛学思想不只是他终身服膺的一种思想学说,也是他一生践履的根本动力。

  7. The Ets dominant repressor En/Erm enhances intestinal epithelial tumorigenesis in ApcMin mice

    Directory of Open Access Journals (Sweden)

    Sui Xiaomei

    2009-06-01

    Full Text Available Abstract Background Ets transcription factors have been widely implicated in the control of tumorigenesis, with most studies suggesting tumor-promoting roles. However, few studies have examined Ets tumorigenesis-modifying functions in vivo using model genetic systems. Methods Using mice expressing a previously characterized Ets dominant repressor transgene in the intestinal epithelium (Villin-En/Erm, we examined the consequences of blocking endogenous Ets-mediated transcriptional activation on tumorigenesis in the ApcMin model of intestinal carcinoma. Results En/Erm expression in the intestine, at levels not associated with overt crypt-villus dysmorphogenesis, results in a marked increase in tumor number in ApcMin animals. Moreover, when examined histologically, tumors from En/Erm-expressing animals show a trend toward greater stromal invasiveness. Detailed analysis of crypt-villus homeostasis in these En/Erm transgenic animals suggests increased epithelial turnover as one possible mechanism for the enhanced tumorigenesis. Conclusion Our findings provide in vivo evidence for a tumor-restricting function of endogenous Ets factors in the intestinal epithelium.

  8. Berberine Inhibits Intestinal Polyps Growth in Apc (min/+) Mice via Regulation of Macrophage Polarization.

    Science.gov (United States)

    Piao, Meiyu; Cao, Hailong; He, NaNa; Yang, Boli; Dong, Wenxiao; Xu, Mengque; Yan, Fang; Zhou, Bing; Wang, Bangmao

    2016-01-01

    Antitumor effect of berberine has been reported in a wide spectrum of cancer, however, the mechanisms of which are not fully understood. The aim of this study was to investigate the hypothesis that berberine suppresses tumorigenesis in the familial adenomatous polyposis (FAP) by regulating the macrophage polarization in Apc (min/+) mouse model. Berberine was given to Apc (min/+) mice for 12 weeks. Primary macrophages were isolated; after berberine treatment, the change in signaling cascade was determined. The total number and size of polyps were reduced remarkably in berberine group, compared with control group. A significant decrease in protein levels of F4/80, mannose receptor (MR), and COX-2 in stroma of intestinal polyps and an increase in the level of iNOS were observed after berberine treatment. The mRNA level of MR and Arg-1 in berberine group was significantly lower than those in IL-10 or IL-4 group, while no significant difference in mRNA levels of iNOS and CXCL10 was observed. The migration and invasiveness assays in vitro showed that berberine could reduce the capability of migration and invasiveness. These findings suggest that berberine attenuates intestinal tumorigenesis by inhibiting the migration and invasion of colorectal tumor cells via regulation of macrophage polarization. PMID:27493671

  9. Lovastatin, but not orlistat, reduces intestinal polyp volume in an ApcMin/+ mouse model.

    Science.gov (United States)

    Notarnicola, Maria; Barone, Michele; Francavilla, Antonio; Tutino, Valeria; Bianco, Giusy; Tafaro, Angela; Minoia, Mario; Polimeno, Lorenzo; Napoli, Anna; Scavo, Maria Principia; Caruso, Maria Gabriella

    2016-08-01

    The statins, inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCoAR) and orlistat, an inhibitor of fatty acid synthase (FAS), inhibit tumor cell growth by restricting cholesterol and fatty acid synthesis, respectively. We previously demonstrated that an omega (ω)-3 polyunsaturated fatty acid (PUFA)- or olive oil-enriched diet reduced the polyp number and volume in ApcMin/+ mice. This phenomenon was associated with a significant inhibition of FAS and HMGCoAR, as well as an increase in the estrogen receptor (ER)β/α ratio. Herein, we evaluated the effect of lovastatin and orlistat on polyp development and ER expression in ApcMin/+ mice, in order to confirm previous data obtained with ω‑3-PUFAs and olive oil. As expected, the use of lovastatin and orlistat significantly reduced HMGCoAR and FAS enzymatic activities and gene expression in colonic tissues, but did not affect the number of intestinal polyps, while there was a statistically significant reduction in polyp volume only in the mouse group treated with lovastatin. In the mice receiving orlistat, we observed a significant increase in cell proliferation in the polyp tissue, as well as enhanced expression of ERα. Moreover, the overexpression of ERα was associated with a statistically significant increase in PES1, Shh and Gli1 protein levels, considered ERα-related molecular targets. PMID:27277576

  10. Inhibition of palmitate-induced GADD34 expression augments apoptosis in mouse insulinoma cells (MIN6).

    Science.gov (United States)

    Fransson, Liselotte; Sjöholm, Ake; Ortsäter, Henrik

    2014-07-01

    Saturated fatty acids like palmitate induce endoplasmic reticulum (ER) stress in pancreatic beta-cells, an event linked to apoptotic loss of β-cells in type 2 diabetes. Sustained activation of the ER stress response leads to expression of growth arrest and DNA damage-inducible protein 34 (GADD34), a regulatory subunit of protein phosphatase 1. In the present study, we have used small interfering RNA in order to knockdown GADD34 expression in insulin-producing MIN6 cells prior to induction of ER stress by palmitate and evaluated its consequences on RNA-activated protein kinase-like ER-localized eIF2alpha kinase (PERK) signalling and apoptosis. Salubrinal, a specific inhibitor of eukaryotic initiation factor 2α (eIF2α) dephosphorylation, was used as a comparison. Salubrinal treatment augmented palmitate-induced ER stress and increased GADD34 levels. Both GADD34 knockdown and salubrinal treatment potentiated the cytotoxic effects of palmitate as evidenced by increased DNA fragmentation and activation of caspase 3, with the fundamental difference that the former did not involve enhanced levels of GADD34. The data from this study suggest that sustained activation of PERK signalling and eIF2α phosphorylation sensitizes insulin-producing MIN6 cells to lipoapoptosis independently of GADD34 expression levels. PMID:24633916

  11. 论敏德的功效%On the efficacy of the Min and Morality

    Institute of Scientific and Technical Information of China (English)

    崔士岚

    2015-01-01

    敏德是孔子道德思想中的重要内容,其内涵为迅疾、审慎、勉力地修身、做事. 因为迅疾、审慎、勉力而为的客观性,所以敏德具有一定的道德功效,即:为学达到博学为道、学以致用的效果;修身达到"内圣外王"的理想人格;为政达到"庶之""富之""教之"的治国理想.%Min and Morality is an important content of Confucius moral thought,and its connotation is swift, prudent,hard working.That connotation just corresponds to learning,self-cultivation,pursuing politics.Because of the objectivity of swift,prudent,hard working,Min and morality takes on some moral effects.For learning,we must adhere to the principle of making study serve the practical purpose.For self-cultivation,we must develop the personality of being virtuous inside and benevolent outside.For pursuing politics,we must strive to make the nation sufficient in 3 population,rich in goods,and colorful in spirit.

  12. Illumination Tolerance for Visual Navigation with the Holistic Min-Warping Method

    Directory of Open Access Journals (Sweden)

    Ralf Möller

    2014-02-01

    Full Text Available Holistic visual navigation methods are an emerging alternative to the ubiquitous feature-based methods. Holistic methods match entire images pixel-wise instead of extracting and comparing local feature descriptors. In this paper we investigate which pixel-wise distance measures are most suitable for the holistic min-warping method with respect to illumination invariance. Two novel approaches are presented: tunable distance measures—weighted combinations of illumination-invariant and illumination-sensitive terms—and two novel forms of “sequential” correlation which are only invariant against intensity shifts but not against multiplicative changes. Navigation experiments on indoor image databases collected at the same locations but under different conditions of illumination demonstrate that tunable distance measures perform optimally by mixing their two portions instead of using the illumination-invariant term alone. Sequential correlation performs best among all tested methods, and as well but much faster in an approximated form. Mixing with an additional illumination-sensitive term is not necessary for sequential correlation. We show that min-warping with approximated sequential correlation can successfully be applied to visual navigation of cleaning robots.

  13. Regional cerebral oxygen saturation in newborn infants in the first 15 min of life after vaginal delivery

    International Nuclear Information System (INIS)

    The objective of this study was to evaluate regional oxygen saturation of the brain during immediate transition after birth, and to correlate it with pre-ductal arterial oxygen saturation in newborn infants. The prospective observational study including newborn infants in the first 15 min after spontaneous vaginal delivery and uncomplicated transitional period was undertaken. Regional cerebral oxygen saturation (rSO2brain) was measured using near-infrared spectroscopy. Arterial oxygen saturation (SpO2) and heart rate (HR) were measured on the right wrist by pulse oximetry. rSO2brain, SpO2 and HR measurements were started immediately after birth and were performed in the first 15 min of life. Cerebral fractional tissue oxygen extraction (FTOE) was calculated for each minute. Of 145 newborn infants, 16 were included and the gender allocation was 31 females (49.2%) and 32 males (50.8%). rSO2brain increased rapidly from 39% (2 min) to 69% (5 min), SpO2 increased from 72% (2 min) to 96% (14 min) and FTOE showed a significant decrease from minute 2 (0.47) until minute 4 (0.30) and an increase between 8 to 13 min. rSO2brain increased rapidly after vaginal delivery. Although SpO2 increased within the first 14 min after delivery, rSO2brain showed no further significant changes after 5 min. FTOE decreased in the first 4 min and reached standard values subsequently. (paper)

  14. Data from the Mars Science Laboratory CheMin XRD/XRF Instrument

    Science.gov (United States)

    Vaniman, David; Blake, David; Bristow, Tom; DesMarais, David; Achilles, Cherie; Anderson, Robert; Crips, Joy; Morookian, John Michael; Spanovich, Nicole; Vasavada, Ashwin; Yen, Albert; Bish, David; Chipera, Steve; Downs, Robert; Morrison, Shaunna; Farmer, Jack; Grotzinger, John; Stolper, Edward; Ming, Douglas; Morris, Richard; Rampe, Elizabeth; Treiman, Allan; Sarrazin, Philippe

    2013-01-01

    The CheMin instrument on the Mars Science Laboratory (MSL) rover Curiosity uses a Co tube source and a CCD detector to acquire mineralogy from diffracted primary X-rays and chemical information from fluoresced X-rays. CheMin has been operating at the MSL Gale Crater field site since August 5, 2012 and has provided the first X-ray diffraction (XRD) analyses in situ on a body beyond Earth. Data from the first sample collected, the Rocknest eolian soil, identify a basaltic mineral suite, predominantly plagioclase (approx.An50), forsteritic olivine (approx.Fo58), augite and pigeonite, consistent with expectation that detrital grains on Mars would reflect widespread basaltic sources. Minor phases (each <2 wt% of the crystalline component) include sanidine, magnetite, quartz, anhydrite, hematite and ilmenite. Significantly, about a third of the sample is amorphous or poorly ordered in XRD. This amorphous component is attested to by a broad rise in background centered at approx.27deg 2(theta) (Co K(alpha)) and may include volcanic glass, impact glass, and poorly crystalline phases including iron oxyhydroxides; a rise at lower 2(theta) may indicate allophane or hisingerite. Constraints from phase chemistry of the crystalline components, compared with a Rocknest bulk composition from the APXS instrument on Curiosity, indicate that in sum the amorphous or poorly crystalline components are relatively Si, Al, Mg-poor and enriched in Ti, Cr, Fe, K, P, S, and Cl. All of the identified crystalline phases are volatile-free; H2O, SO2 and CO2 volatile releases from a split of this sample analyzed by the SAM instrument on Curiosity are associated with the amorphous or poorly ordered materials. The Rocknest eolian soil may be a mixture of local detritus, mostly crystalline, with a regional or global set of dominantly amorphous or poorly ordered components. The Rocknest sample was targeted by MSL for "first time analysis" to demonstrate that a loose deposit could be scooped, sieved to

  15. MinUrals: Mineral resources of the Urals -- origin, development, and environmental impact

    Science.gov (United States)

    Leistel, J. M.; Minurals Team

    2003-04-01

    The MinUrals project (supported by the European Commission under the 5th F.P.- INCO2 - contract ICA2-CT-2000-10011) is focusing on the South Urals mining sector, in order to improve local socio-economic conditions, through: 1) The reinterpretation of the geodynamics of South Urals and of the different types of ore deposits and the development of tools for mineral exploration (new geophysical and geochemical technology). The convergence setting and the formation of arc, fore-arc and back-arc systems explain the volcano-sedimentary and structural features. This geodynamic setting largely controls the distribution and characteristics of the different types of mineralisation; 2) The evaluation of local mining-related risks to the environment, with a development of methodologies for assessing and reducing the environmental impact and localizing areas of high metal potential/low environmental constraints. Three pilote sites were investigated: Sibay and Uchaly (with mining installations), and Karabash (with mining installations and smelter); 3) The implementation of a Geographical Information System taking into account the mineral potential and the environmental constraints that, through data ranking and combining the key parameters of the areas with high metal potential and environmental constraints, will enable the production of a Mineral Potential and Environmental Constraints Map of the South Urals; 4) The elaboration of recommendations for a suitable environmentally-aware mining-industry legislation, based on a comparison with the European legislation, to be adressed to the Commission on the demarcation of powers and subjects between the federal government, governments of the subjects of the Russian Federation and local authorities. More information can be found on the project web sites [http://minurals.brgm.fr] or [http://www.nhm.ac.uk/mineralogy/minurals/minurals.htm] or [http://www.anrb.ru/geol/MinUrals] or [http://minurals.ilmeny.ac.ru] MinUrals Team (*): Aug

  16. Minerals detection for hyperspectral images using adapted linear unmixing: LinMin

    CERN Document Server

    Frederic, Schmidt; Stephane, Le Mouelic

    2014-01-01

    Minerals detection over large volume of spectra is the challenge addressed by current hyperspectral imaging spectrometer in Planetary Science. Instruments such OMEGA (Mars Express), CRISM (Mars Reconnaissance Orbiter), M^{3} (Chandrayaan-1), VIRTIS (Rosetta) and many more, have been producing very large datasets since one decade. We propose here a fast supervised detection algorithm called LinMin, in the framework of linear unmixing, with innovative arrangement in order to treat non-linear cases due to radiative transfer in both atmosphere and surface. We use reference laboratory and synthetic spectral library. Additional spectra are used in order to mimic the effect of Martian aerosols, grain size, and observation geometry discrepancies between reference and observed spectra. The proposed algorithm estimates the uncertainty on mixing coefficient from the uncertainty of observed spectra. Both numerical and observational tests validate the approach. Fast parallel implementation of the best algorithm (IPLS) on ...

  17. A Randomized Load Balancing Algorithm In Grid using Max Min PSO Algorithm

    Directory of Open Access Journals (Sweden)

    C.Kalpana

    2012-04-01

    Full Text Available Grid computing is a new paradigm for next generation computing, it enables the sharing and selection of geographically distributed heterogeneous resources for solving large scale problems in science and engineering. Grid computing does require special software that is unique to the computing project for which the grid is being used. In this paper the proposed algorithm namely dynamic load balancing algorithm is created for job scheduling in Grid computing. Particle Swarm Intelligence (PSO is the latest evolutionary optimization techniques in Swarm Intelligence. It has the better performance of global searching and has been successfully applied to many areas. The performance measure used for scheduling is done by Quality of service (QoS such as makespan, cost and deadline. Max PSO and Min PSO algorithm has been partially integrated with PSO and finally load on the resources has been balanced.

  18. Glucose enhances collectrin protein expression in insulin-producing MIN6 {beta} cells

    Energy Technology Data Exchange (ETDEWEB)

    Saisho, Kenji; Fukuhara, Atsunori [Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Osaka (Japan); Yasuda, Tomoko [Department of Medical Biochemistry, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University, Kumamoto (Japan); Sato, Yoshifumi; Fukui, Kenji; Iwahashi, Hiromi; Imagawa, Akihisa [Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Osaka (Japan); Hatta, Mitsutoki [Department of Medical Biochemistry, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University, Kumamoto (Japan); Shimomura, Iichiro [Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Osaka (Japan); Yamagata, Kazuya, E-mail: k-yamaga@kumamoto-u.ac.jp [Department of Medical Biochemistry, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University, Kumamoto (Japan)

    2009-11-06

    Collectrin is a novel target gene of hepatocyte nuclear factor-1{alpha} in pancreatic {beta}-cells and controls insulin exocytosis. Although glucose is known to stimulate the expression of genes of the insulin secretory pathway, there is no information on how glucose regulates collectrin expression. We investigated the effects of glucose on the expression of collectrin in MIN6 {beta}-cell line. Glucose, in a dose-dependent manner, increased collectrin protein levels without changing collectrin mRNA levels and protein stability, indicating that glucose stimulation of collectrin protein expression is primarily mediated at a translational level. Although mannose and pyruvate also increased collectrin protein expression level, neither 2-deoxyglucose, mitochondrial fuels leucine and glutamate, sulphonylurea nor Ca{sup 2+} channel blockers, mimicked the effects of glucose. These data indicate the involvement of mitochondrial TCA cycle intermediates, distal to pyruvate, in the regulation of collectrin protein expression in {beta}-cells.

  19. Min-max fair coordinated beamforming in cellular systems via large systems analysis

    CERN Document Server

    Zakhour, Randa

    2012-01-01

    This paper considers base station (BS) cooperation in the form of coordinated beamforming, focusing on min-max fairness in the power usage subject to target SINR constraints. We show that the optimal beamforming strategies have an interesting nested zero-forcing structure. In the asymptotic regime where the number of antennas at each BS and the number of users in each cell both grow large with their ratio tending to a finite constant, the dimensionality of the optimization is greatly reduced, and only knowledge of statistics is required to solve it. The optimal solution is characterized in general, and an algorithm is proposed that converges to the optimal transmit parameters, for feasible SINR targets. For the two cell case, a simple single parameter characterization is obtained. These asymptotic results provide insights into the average performance, as well as simple but efficient beamforming strategies for the finite system case. In particular, the optimal beamforming strategy from the large systems analys...

  20. Simple Max-Min Ant Systems and the Optimization of Linear Pseudo-Boolean Functions

    CERN Document Server

    Kötzing, Timo; Sudholt, Dirk; Wagner, Markus

    2010-01-01

    With this paper, we contribute to the understanding of ant colony optimization (ACO) algorithms by formally analyzing their runtime behavior. We study simple MAX-MIN ant systems on the class of linear pseudo-Boolean functions defined on binary strings of length 'n'. Our investigations point out how the progress according to function values is stored in pheromone. We provide a general upper bound of O((n^3 \\log n)/ \\rho) for two ACO variants on all linear functions, where (\\rho) determines the pheromone update strength. Furthermore, we show improved bounds for two well-known linear pseudo-Boolean functions called OneMax and BinVal and give additional insights using an experimental study.

  1. Min Bei Irradiation Center. Food and Agriculture organization project experience, Jianou, Fujian Province, China

    International Nuclear Information System (INIS)

    The Food and Agriculture Organization (FAO), a United Nations Organization, in an effort to increase food supplies by post harvest irradiation treatment, participated in the development of the Min Bei Irradiation Center (MBIC) located in Fujian Province, China. FAO in conjunction with Shanghai Nuclear Energy Research and Design Institute (SNERDI), MBIC staff, and the Ministry of Agriculture completed Project TCP CPR 6763/8961 culminating in the recent commissioning of one of China's newest irradiation facilities. From the feasibility phase initiated in 1986, through the construction period and the eventual commissioning in 1991, FAO participated in the technical overview of the irradiation center. MBIC was developed both as a research and development center as well as a production irradiation facility for the primary purpose of reduction of post harvest food loss in Fujian Province. This retrospective review of the project provides a hindsight view for the development of MBIC. (author)

  2. Mash: fast genome and metagenome distance estimation using MinHash.

    Science.gov (United States)

    Ondov, Brian D; Treangen, Todd J; Melsted, Páll; Mallonee, Adam B; Bergman, Nicholas H; Koren, Sergey; Phillippy, Adam M

    2016-01-01

    Mash extends the MinHash dimensionality-reduction technique to include a pairwise mutation distance and P value significance test, enabling the efficient clustering and search of massive sequence collections. Mash reduces large sequences and sequence sets to small, representative sketches, from which global mutation distances can be rapidly estimated. We demonstrate several use cases, including the clustering of all 54,118 NCBI RefSeq genomes in 33 CPU h; real-time database search using assembled or unassembled Illumina, Pacific Biosciences, and Oxford Nanopore data; and the scalable clustering of hundreds of metagenomic samples by composition. Mash is freely released under a BSD license ( https://github.com/marbl/mash ). PMID:27323842

  3. Fabrication of a cantilever-based microfluidic flow meter with nL min(-1) resolution

    DEFF Research Database (Denmark)

    Noeth, Nadine-Nicole; Keller, Stephan Sylvest; Boisen, Anja

    2011-01-01

    A microfluidic flow meter based on cantilever deflection is developed, showing a resolution down to 3 nL min(-1) for flows in the microliter range. The cantilevers are fabricated in SU-8 and have integrated holes with dimensions from 5 x 5 to20x 20 mu m(2). The holes make it possible to measure......). With this etch the cantilever structures are under-etched before they are released by tweezers and the release yield is enhanced from 41.5% to 84.0%. In a continuous flow mode, the deflection of the cantilevers is directly proportional to the flow rate. By tuning the design of the integrated grid (hole size......, hole-to-hole distance, amount of holes, etc) the sensitivity of the sensor can be changed....

  4. Laypersons may learn basic life support in 24min using a personal resuscitation manikin

    DEFF Research Database (Denmark)

    Isbye, Dan Lou; Rasmussen, Lars Simon; Lippert, Freddy Knudsen;

    2006-01-01

    BACKGROUND: Bystander basic life support (BLS) is an important part of cardiopulmonary resuscitation (CPR) and improves outcome after out-of-hospital cardiac arrest. However, the general population has poor BLS skills. Several training initiatives could be used to improve this situation and the c......BACKGROUND: Bystander basic life support (BLS) is an important part of cardiopulmonary resuscitation (CPR) and improves outcome after out-of-hospital cardiac arrest. However, the general population has poor BLS skills. Several training initiatives could be used to improve this situation...... assessed after 3 months, a 24 min DVD-based instruction plus subsequent self-training in BLS appears equally effective compared to a 6h BLS course and hence is more efficient. Udgivelsesdato: 2006-Jun...

  5. PWRs in UK and China use 3000r/min turbines

    International Nuclear Information System (INIS)

    The new steam turbine design by GEC Turbine Generators Ltd. are 3 to 5 percentage points more efficient than previous turbine designs. They also require fewer manufacturing manhours to make. GEC has won the contracts for the steam turbine at the Daya Bay power station in China and Sizewell-B in the UK. Both are pressurized water reactors. The main parameters for these 300r/min steam turbines are listed. The existing and new GEC turbines for water cooled reactors are listed and the operation of the new turbines is explained. The high pressure stop and governing valves and the arrangement of spring-supported horizontal high pressure valve chests are illustrated. (UK)

  6. Caffeine, but not bicarbonate, improves 6 min maximal performance in elite rowers

    DEFF Research Database (Denmark)

    Christensen, Peter Møller; Petersen, Mads H; Friis, Signe N;

    2014-01-01

    This study examined the ergogenic effects in a 6 min maximal performance test (PT) on 12 elite rowers: 6 open-weight (mean ± SD; 25 ± 1 years, and 92 ± 3 kg) and 6 light-weight (25 ± 3 years, and 73 ± 6 kg), following supplementation with caffeine (CAF), sodium bicarbonate (SB), and the combination.......05) than in open-weight rowers (0.3% ± 0.8%; P > 0.05). No difference between interventions was observed for readiness and stomach comfort before PT and perceived exertion during PT. This study demonstrates that caffeine ingestion does improve performance in elite rowing. In contrast sodium bicarbonate...... does not appear to be ergogenic, but it does not abolish the ergogenic effect of caffeine....

  7. METAPHORIZATION AND METONYMIZATIO: DIACHRONIC DEVELOPMENT OF VERBS OF VOLITION IN SOUTHERN MIN

    Directory of Open Access Journals (Sweden)

    Miao-Hsia Chang

    2009-06-01

    Full Text Available This paper investigates the diachrony of the verbs of volition ai and beh in Southern Min (SM. The data include historical SM texts (16th-19th century, folk songs in the late 19th to early 20th century, and contemporary natural Taiwanese Southern Min conversations. The results mainly mark two stages of the development of ai and beh: historical (before 1900 and contemporary SM. Since the 16th century (Ming Dynasty, ai has been used as a verb of volition indicating love, intention or hope. As for historical ai, it marked future, specialized however for predicting an adverse future. In contemporary SM, a sense of necessity emerged with the use of ai denoting general agreement among people. Seven senses are attributed to historical beh: want/intention/hope, future, excessiveness, necessity, proximity and conditionality. In contemporary SM, the indication of the want of an entity has become a less preferred use, and necessity is only preserved when indicating puzzlement and helplessness. The diachronic developments of ai and beh demonstrate an interplay of metaphorization and metonymization (Traugott and Dasher 2002:27. Metaphorization contributes first to the semantic shift of ai and beh from “to want; to love” to “to intend to” and a concurrent categorical change from lexical verb into auxiliary, and second, to the evolution of future. Metonymization activates an even wider range of uses and meaning change, including the pragmatic strengthening of interpretations such as excessiveness (beh, necessity (ai, beh, proximity (beh and conditional (beh, and prediction of an undesirable future (ai.

  8. Chemopreventive Effects of RXR-Selective Rexinoid Bexarotene on Intestinal Neoplasia of ApcMin/+ Mice

    Directory of Open Access Journals (Sweden)

    Naveena B. Janakiram

    2012-02-01

    Full Text Available Retinoid X receptor (RXR has been implicated in several neoplastic diseases. Previously, we have shown that RXR-α is downregulated in human and rodent colonic tumors, suggesting a potential target for colon cancer prevention (http://www.cancer.org/Cancer/ColonandRectumCancer/DetailedGuide/colorectal-cancer-key-statistics. Experiments were designed to assess the chemopreventive efficacy of the selective RXR agonist bexarotene for the suppression of intestinal tumorigenesis in ApcMin/+ mice. Before the efficacy studies, we determined that the maximal tolerated dose in C57BL/6J mice was less than 400 ppm. For the efficacy study, 6-week-old male and female C57BL/6J-ApcMin/+ mice (nine mice per group were fed diets containing 0, 30, and 60 ppm of bexarotene or 200 ppm of bexarotene for 80 days before intestinal tumors were evaluated. Dietary administration of 30 and 60 ppm of bexarotene suppressed the intestinal polyp formation by 38% (P < .015 and 60% (P < .0001 in males, respectively, and by 8.5% and 37% (P < .007 in females, respectively. Also, significant inhibition (50%–100% of colonic tumor formation was observed in both male and female mice with bexarotene treatment. Administration of 200 ppm of bexarotene showed significant suppression of tumor formation (66%, P < .0001; however, it had significant toxicity. Intestinal tumors of bexarotene-fed mice showed significantly reduced expression of proliferating cell nuclear antigen (60%, P < .0001, cyclin D1, and cyclooxygenase 2 and increased RXR-α messenger RNA and uptake of oleate (34%, P < .01. Also, bexarotene-fed mice showed dose-dependent suppression of serum triglycerides (25%–72%, P < .0001 and inflammatory cytokines.

  9. MicroPET/CT Colonoscopy in long-lived Min mouse using NM404

    Science.gov (United States)

    Christensen, Matthew B.; Halberg, Richard B.; Schutten, Melissa M.; Weichert, Jamey P.

    2009-02-01

    Colon cancer is a leading cause of death in the US, even though many cases are preventable if tumors are detected early. One technique to promote screening is Computed Tomography Colonography (CTC). NM404 is a second generation phospholipid ether analogue which has demonstrated selective uptake and prolonged retention in 43/43 types of malignant tumors but not inflammatory sites or premalignant lesions. The purpose of this experiment was to evaluate (SWR x B6 )F1.Min mice as a preclinical model to test MicroPET/CT dual modality virtual colonoscopy. Each animal was given an IV injection of 124I-NM404 (100 uCi) 24, 48 and 96 hours prior to scanning on a dedicated microPET/CT system. Forty million counts were histogrammed in 3D and reconstructed using an OSEM 2D algorithm. Immediately after PET acquisition, a 93 m volumetric CT was acquired at 80 kVp, 800 uA and 350 ms exposures. Following CT, the mouse was sacrificed. The entire intestinal tract was excised, washed, insufflated, and scanned ex vivo A total of eight tissue samples from the small intestine were harvested: 5 were benign adenomas, 2 were malignant adenocarcinomas, and 1 was a Peyer's patch (lymph tissue) . The sites of these samples were positioned on CT and PET images based on morphological cues and the distance from the anus. Only 1/8 samples showed tracer uptake. several hot spots in the microPET image were not chosen for histology. (SWR x B6)F1.Min mice develop benign and malignant tumors, making this animal model a strong candidate for future dual modality microPET/CT virtual colonography studies.

  10. C57BL/KsJ-db/db-ApcMin/+ Mice Exhibit an Increased Incidence of Intestinal Neoplasms

    Directory of Open Access Journals (Sweden)

    Yoshinobu Hirose

    2011-11-01

    Full Text Available The numbers of obese people and diabetic patients are ever increasing. Obesity and diabetes are high-risk conditions for chronic diseases, including certain types of cancer, such as colorectal cancer (CRC. The aim of this study was to develop a novel animal model in order to clarify the pathobiology of CRC development in obese and diabetic patients. We developed an animal model of obesity and colorectal cancer by breeding the C57BL/KsJ-db/db (db/db mouse, an animal model of obesity and type II diabetes, and the C57BL/6J-ApcMin/+ (Min/+ mouse, a model of familial adenomatous polyposis. At 15 weeks of age, the N9 backcross generation of C57BL/KsJ-db/db-ApcMin/+ (db/db-Min/+ mice developed an increased incidence and multiplicity of adenomas in the intestinal tract when compared to the db/m-Min/+ and m/m-Min/+ mice. Blood biochemical profile showed significant increases in insulin (8.3-fold to 11.7-fold, cholesterol (1.2-fold to 1.7-fold, and triglyceride (1.2-fold to 1.3-fold in the db/db-Min/+ mice, when compared to those of the db/m-Min/+ and m/m-Min/+ mice. Increases (1.4-fold to 2.6-fold in RNA levels of insulin-like growth factor (IGF-1, IRF-1R, and IGF-2 were also observed in the db/db-Min/+ mice. These results suggested that the IGFs, as well as hyperlipidemia and hyperinsulinemia, promoted adenoma formation in the db/db-Min/+ mice. Our results thus suggested that the db/db-Min/+ mice should be invaluable for studies on the pathogenesis of CRC in obese and diabetes patients and the therapy and prevention of CRC in these patients.

  11. Identification of the Modifier of Min 2 (Mom2) Locus, a New Mutation That Influences Apc-Induced Intestinal Neoplasia

    OpenAIRE

    Silverman, Karen A.; Koratkar, Revati; Linda D. Siracusa; Buchberg, Arthur M.

    2002-01-01

    Min (Multiple intestinal neoplasia) mice carry a dominant mutation in the adenomatous polyposis coli (Apc) gene and develop multiple adenomas throughout their intestinal tract (Moser et al. 1990; Su et al. 1992). Polyp multiplicity in Min mice is greatly influenced by genetic background. A modifier locus, Mom1 (Modifier of Min 1), was identified and localized to distal mouse chromosome 4 (Moser et al. 1992; Dietrich et al. 1993), and accounts for some of the genetic variance in polyp multipli...

  12. 基于QoS Guided Min-min改进后的网格调度算法

    Institute of Scientific and Technical Information of China (English)

    徐益强; 王志坚; 许峰

    2007-01-01

    在对网格调度现有算法的研究基础之上,对QoS Guided Min-min算法进行了分析,介绍了在任务对资源有特殊要求时算法的不足,并对其进行了改进.最后,使用GridSim模拟任务调度,对Min-min算法、QoS Guided Min-min算法和改进后的QoS Guided Min-min算法进行对比分析,验证了改进后算法的高效性.

  13. Consecutive 15 min is necessary for focal low frequency stimulation to inhibit amygdaloid-kindling seizures in rats.

    Science.gov (United States)

    Liu, Yang; Wang, Yi; Xu, Zhenghao; Xu, Cenglin; Ying, Xiaoying; Wang, Shuang; Zhang, Shihong; Xiao, Bo; Chen, Zhong

    2013-09-01

    Low-frequency stimulation (LFS) is emerging as a new option for the treatment of intractable epilepsy. The stimulation duration may influence the anti-epileptic effect of LFS but is poorly studied. The present study was designed to evaluate the anti-epileptic effect of focal LFS with different stimulation duration on amygdaloid-kindling seizures in rats. We found 15 and 30 min but not 1 or 5 min LFS delivered immediately after the kindling stimulation slowed the progression of behavioral seizure stages and reduced mean afterdischarge duration (ADD) during kindling acquisition. In fully kindled animals, 15 and 30min rather than 1 and 5 min LFS decreased the incidence of generalized seizures and the average seizure stage as well as shortened the cumulative generalized seizure duration (GSD). Meanwhile, EEG analysis showed 15 and 30 min LFS specifically lowered the power in delta band. However, if 15min LFS delivered intermittently by 5 min interval, it had no suppressing effect on kindling rat. Thus, it is likely that consecutive 15 min is necessary for LFS to inhibit amygdaloid-kindling seizures in rats, indicating the stimulation duration may be a key fact affecting the clinical effect of LFS on epilepsy.

  14. Spectroscopic study on the interaction between mononaphthalimide spermidine (MINS) and bovine serum albumin (BSA).

    Science.gov (United States)

    Tian, Zhiyong; Zang, Fenglei; Luo, Wen; Zhao, Zhonghua; Wang, Yueqiao; Xu, Xuejun; Wang, Chaojie

    2015-01-01

    The interaction mononaphthalimide spermidine (MINS, 1) and bovine serum albumin (BSA) was studied by UV/vis absorption, fluorescence and circular dichroism spectra (CD) under physiological conditions (pH=7.4). The observed spectral quenching of BSA by compound 1 indicated compound 1 could bind to BSA. Further fluorescent tests revealed that the quenching mechanism of BSA by compound 1 was overall static. Meanwhile, the obtained binding constant and thermodynamic parameters on compound-BSA interaction showed that the type of interaction force of compound 1 and BSA was mainly hydrophobic. The analysis of synchronous, three-dimensional fluorescence and CD showed that compound 1 had weak influence on the conformational changes in BSA. Molecular docking simulation was performed and docking model in silico suggested that the configuration of compound 1 was localized in enzymatic drug site II in BSA. Furthermore, naphthalimide moiety of compound 1 greatly contributed to the hydrophobic interaction between compound 1 and BSA protein, as confirmed by experimental data.

  15. Monitoring the informational efficiency of European corporate bond markets with dynamical permutation min-entropy

    Science.gov (United States)

    Zunino, Luciano; Bariviera, Aurelio F.; Guercio, M. Belén; Martinez, Lisana B.; Rosso, Osvaldo A.

    2016-08-01

    In this paper the permutation min-entropy has been implemented to unveil the presence of temporal structures in the daily values of European corporate bond indices from April 2001 to August 2015. More precisely, the informational efficiency evolution of the prices of fifteen sectorial indices has been carefully studied by estimating this information-theory-derived symbolic tool over a sliding time window. Such a dynamical analysis makes possible to obtain relevant conclusions about the effect that the 2008 credit crisis has had on the different European corporate bond sectors. It is found that the informational efficiency of some sectors, namely banks, financial services, insurance, and basic resources, has been strongly reduced due to the financial crisis whereas another set of sectors, integrated by chemicals, automobiles, media, energy, construction, industrial goods & services, technology, and telecommunications has only suffered a transitory loss of efficiency. Last but not least, the food & beverage, healthcare, and utilities sectors show a behavior close to a random walk practically along all the period of analysis, confirming a remarkable immunity against the 2008 financial crisis.

  16. Quasi-Polynomial Local Search for Restricted Max-Min Fair Allocation

    CERN Document Server

    Polacek, Lukas

    2012-01-01

    The restricted max-min fair allocation problem (also known as the restricted Santa Claus problem) is one of few problems that enjoys the intriguing status of having a better estimation algorithm than approximation algorithm. Indeed, Asadpour et al. proved that a certain configuration LP can be used to estimate the optimal value within a factor ${1}/{(4+\\epsilon)}$, for any $\\epsilon>0$, but at the same time it is not known how to efficiently find a solution with a comparable performance guarantee. A natural question that arises from their work is if the difference between these guarantees is inherent or because of a lack of suitable techniques. We address this problem by giving a quasi-polynomial approximation algorithm with the mentioned performance guarantee. More specifically, we modify the local search of Asadpour et al. and provide a novel analysis that lets us significantly improve the bound on its running time: from $2^{O(n)}$ to $n^{O(\\log n)}$. Our techniques also have the interesting property that a...

  17. Convergence of Weighted Min-Sum Decoding Via Dynamic Programming on Trees

    CERN Document Server

    Jian, Yung-Yih

    2011-01-01

    Applying the max-product (and belief-propagation) algorithms to loopy graphs is now quite popular for best assignment problems. This is largely due to their low computational complexity and impressive performance in practice. Still, there is no general understanding of the conditions required for convergence and/or the optimality of converged solutions. This paper presents an analysis of both attenuated max-product (AMP) decoding and weighted min-sum (WMS) decoding for LDPC codes which guarantees convergence to a fixed point when a weight parameter, {\\beta}, is sufficiently small. It also shows that, if the fixed point satisfies some consistency conditions, then it must be both the linear-programming (LP) and maximum-likelihood (ML) solution. For (dv,dc)-regular LDPC codes, the weight must satisfy {\\beta}(dv-1) \\leq 1 whereas the results proposed by Frey and Koetter require instead that {\\beta}(dv-1)(dc-1) 1 is also given. Finally, connections are explored with recent work by Arora et al. on the threshold of...

  18. Insights from lncRNAs Profiling of MIN6 Beta Cells Undergoing Inflammation

    Directory of Open Access Journals (Sweden)

    Chuntao Sun

    2016-01-01

    Full Text Available Type 1 diabetes mellitus (T1DM is an organ-specific autoimmune disease characterized by chronic and progressive apoptotic destruction of pancreatic beta cells. During the initial phases of T1DM, cytokines and other inflammatory mediators released by immune cells progressively infiltrate islet cells, induce alterations in gene expression, provoke functional impairment, and ultimately lead to apoptosis. Long noncoding RNAs (lncRNAs are a new important class of pervasive genes that have a variety of biological functions and play key roles in many diseases. However, whether they have a function in cytokine-induced beta cell apoptosis is still uncertain. In this study, lncRNA microarray technology was used to identify the differently expressed lncRNAs and mRNAs in MIN6 cells exposed to proinflammatory cytokines. Four hundred forty-four upregulated and 279 downregulated lncRNAs were detected with a set filter fold-change ≧2.0. To elucidate the potential functions of these lncRNAs, Gene Ontology (GO and pathway analyses were used to evaluate the potential functions of differentially expressed lncRNAs. Additionally, a lncRNA-mRNA coexpression network was constructed to predict the interactions between the most strikingly regulated lncRNAs and mRNAs. This study may be utilized as a background or reference resource for future functional studies on lncRNAs related to the diagnosis and development of new therapies for T1DM.

  19. A Complexity Reduction Method for Extended Min-Sum based Nonbinary LDPC Decoder

    Directory of Open Access Journals (Sweden)

    M Anbuselvi

    2014-01-01

    Full Text Available Nonbinary LDPC codes are a class of linear block codes having the performance closer to Shannon’s limit. Codes defined over higher order of Galois field, have increased computation complexity and thereby it put forth the challenges in efficient hardware realization of the decoder. In this paper, modifications in the Non-binary LDPC decoder to obtain reduced configuration sets, aimed to reduce the decoding complexity is proposed. Configuration sets are the possible combinations of the message sets that are involved in the parity check equation of LDPC decoder. Min-sum algorithm based decoder is modelled with the specification of IEEE 802.11n standard, with the codelength of 648, rate ½ for GF (4 Galois field, over the AWGN channel. The mathematical formulation of the proposed complexity reduction methodology is presented. The decoding performance of reduced configuration sets is analyzed and it is found that the complexity is reduced by an average of 83%, with negligible degradation in performance in terms of bit error rate.

  20. Examination of spatiotemporal gait parameters during the 6-min walk in individuals with multiple sclerosis.

    Science.gov (United States)

    Socie, Michael J; Motl, Robert W; Sosnoff, Jacob J

    2014-12-01

    This investigation examined spatiotemporal parameters of gait during the 6-min walk (6MW) in individuals with multiple sclerosis (MS) and in healthy controls. Eighteen individuals with MS [divided into those who were independently ambulatory (n=10) and those who were ambulatory with assistance (n=8)] and 10 healthy controls performed a 6MW while recording spatiotemporal gait parameters using a pressure-sensitive walkway. Parameters recorded were walking velocity, cadence, step length and width, step time, percent of the gait cycle in double support, and variability of step length and width, step time, and double support. The ambulatory with assistance MS group had a significantly greater reduction in walking velocity (P=0.000) over the course of the 6MW, which coincided with a significantly greater increase in step time and double support (P=0.029) than in the other groups. Only the ambulatory with assistance MS group showed an increase in step-time variability and double-support variability during the 6MW (P's<0.05). The novel results indicate that the reduction in velocity over prolonged walking occurs through a greater change in the temporal parameters of gait in persons with MS who require assistance while walking. In addition, the increase in gait variability in the individuals with MS who require assistance while walking indicates that the control over walking further deteriorates over the course of the 6MW. PMID:25117855

  1. A Study of Min Gui, a Native of Huzhou%闵珪考略

    Institute of Scientific and Technical Information of China (English)

    潘明福

    2011-01-01

    闵珪乃明代湖州籍名臣,一生屡按数省,四任刑官,平叛抚民。政绩卓著。为人刚直,治狱严正,为人所称道。依据相关典籍,勾勒闵珪的生平事迹,有助于更深入、更全面了解这位明代湖州籍名臣。%Min Gui, a native of Huzhou, was a famous official in the Ming Dynasty. In his life he was appointed as an official in several provinces and he was made an official in charge of penalty four times, suppressing rebels and helping the people with eminent achievements. He was upright and outspoken, and strict and just in governing the jail, so he was greatly respected and admired. This article, based on relative books and historical literatures, briefly tells about his life and deeds, which contributes to understand this famous official of Huzhou origin in a more profound and all round way.

  2. Max-Min Optimality of Service Rate Control in Closed Queueing Networks

    KAUST Repository

    Xia, Li

    2013-04-01

    In this technical note, we discuss the optimality properties of service rate control in closed Jackson networks. We prove that when the cost function is linear to a particular service rate, the system performance is monotonic w.r.t. (with respect to) that service rate and the optimal value of that service rate can be either maximum or minimum (we call it Max-Min optimality); When the second-order derivative of the cost function w.r.t. a particular service rate is always positive (negative), which makes the cost function strictly convex (concave), the optimal value of such service rate for the performance maximization (minimization) problem can be either maximum or minimum. To the best of our knowledge, this is the most general result for the optimality of service rates in closed Jackson networks and all the previous works only involve the first conclusion. Moreover, our result is also valid for both the state-dependent and load-dependent service rates, under both the time-average and customer-average performance criteria.

  3. Dopamine Receptor Signaling in MIN6 β-Cells Revealed by Fluorescence Fluctuation Spectroscopy.

    Science.gov (United States)

    Caldwell, Brittany; Ustione, Alessandro; Piston, David W

    2016-08-01

    Insulin secretion defects are central to the development of type II diabetes mellitus. Glucose stimulation of insulin secretion has been extensively studied, but its regulation by other stimuli such as incretins and neurotransmitters is not as well understood. We investigated the mechanisms underlying the inhibition of insulin secretion by dopamine, which is synthesized in pancreatic β-cells from circulating L-dopa. Previous research has shown that this inhibition is mediated primarily by activation of the dopamine receptor D3 subtype (DRD3), even though both DRD2 and DRD3 are expressed in β-cells. To understand this dichotomy, we investigated the dynamic interactions between the dopamine receptor subtypes and their G-proteins using two-color fluorescence fluctuation spectroscopy (FFS) of mouse MIN6 β-cells. We show that proper membrane localization of exogenous G-proteins depends on both the Gβ and Gγ subunits being overexpressed in the cell. Triple transfections of the dopamine receptor subtype and Gβ and Gγ subunits, each labeled with a different-colored fluorescent protein (FP), yielded plasma membrane expression of all three FPs and permitted an FFS evaluation of interactions between the dopamine receptors and the Gβγ complex. Upon dopamine stimulation, we measured a significant decrease in interactions between DRD3 and the Gβγ complex, which is consistent with receptor activation. In contrast, dopamine stimulation did not cause significant changes in the interactions between DRD2 and the Gβγ complex. These results demonstrate that two-color FFS is a powerful tool for measuring dynamic protein interactions in living cells, and show that preferential DRD3 signaling in β-cells occurs at the level of G-protein release. PMID:27508444

  4. Oxygen desaturation in 6-min walk test is a risk factor for adverse outcomes in COPD.

    Science.gov (United States)

    Waatevik, Marie; Johannessen, Ane; Gomez Real, Francisco; Aanerud, Marianne; Hardie, Jon Andrew; Bakke, Per Sigvald; Lind Eagan, Tomas Mikal

    2016-07-01

    The 6-min walk test (6MWT) is an exercise test that measures functional status in chronic obstructive pulmonary disease (COPD) patients and provides information on oxygen desaturation. We investigated oxygen desaturation during 6MWT as a risk factor for important COPD outcomes: mortality, frequency of exacerbations, decline in lung function and decline in lean body mass.433 COPD patients were included in the Bergen COPD Cohort Study 2006-2009, and followed-up for 3 years. Patients were characterised using spirometry, bioelectrical impedance measurements, Charlson comorbidity score, exacerbation history, smoking and arterial blood gases. 370 patients completed the 6MWT at the baseline of the study. Information on all-cause mortality was collected in 2011.Patients who experienced oxygen desaturation during the 6MWT had an approximately twofold increased risk of death (hazard ratio 2.4, 95% CI 1.2-5.1), a 50% increased risk for experiencing later COPD exacerbations (incidence rate ratio 1.6, 95% CI 1.1-2.2), double the yearly rate of decline in both forced vital capacity and forced expiratory volume in 1 s (3.2% and 1.7% versus 1.7% and 0.9%, respectively) and manifold increased yearly rate of loss of lean body mass (0.18 kg·m(-2) versus 0.03 kg·m(-2) among those who did not desaturate).Desaturating COPD patients had a significantly worse prognosis than non-desaturating COPD patients, for multiple important disease outcomes. PMID:27076586

  5. Vidas célebres, vidas minúsculas: Vasari, Foucault, Michon

    Directory of Open Access Journals (Sweden)

    Kelvin Falcão

    2014-12-01

    Full Text Available O primeiro movimento deste ensaio consiste no esboço de um percurso breve a partir da obra de Michel Foucault, rastreando o uso do significante “vidas” em alguns textos do autor francês. Dois eixos são delineados a partir daí: o primeiro deles diz respeito à leitura foucaultiana das “vidas célebres” de Giorgio Vasari; o segundo diz respeito às “vidas infames”, que Foucault rastreia nos arquivos policiais franceses. Em seguida, inicia-se um desvio em direção à literatura do século XX, considerando o envolvimento da ficção com a emergência da discursividade biográfica, sua ressonância política e o emprego crítico, mais uma vez, do significante “vidas”. Com esse contexto de fundo estabelecido, o ensaio conclui-se com uma análise de Vidas minúsculas, do escritor francês Pierre Michon. The first movement of this essay is to outline a brief path from the work of Michel Foucault, tracking the use of the signifier “lives” in some texts of the French author. Two axes are delineated from there, the first one concerns Foucault’s reading of “renowed lives” by Giorgio Vasari; the second concerns the “infamous lives”, which Foucault traces from the French police files. Then begins a shift toward twentiethcentury literature, considering the involvement of fiction with the emergence of biographical discourse, its political resonance and, again, the critical use of the signifier “lives”. With this background context established, the essay concludes with a analysis of Small Lives, by French writer Pierre Michon.

  6. Benchmarking of the Oxford Nanopore MinION sequencing for quantitative and qualitative assessment of cDNA populations.

    Science.gov (United States)

    Oikonomopoulos, Spyros; Wang, Yu Chang; Djambazian, Haig; Badescu, Dunarel; Ragoussis, Jiannis

    2016-01-01

    To assess the performance of the Oxford Nanopore Technologies MinION sequencing platform, cDNAs from the External RNA Controls Consortium (ERCC) RNA Spike-In mix were sequenced. This mix mimics mammalian mRNA species and consists of 92 polyadenylated transcripts with known concentration. cDNA libraries were generated using a template switching protocol to facilitate the direct comparison between different sequencing platforms. The MinION performance was assessed for its ability to sequence the cDNAs directly with good accuracy in terms of abundance and full length. The abundance of the ERCC cDNA molecules sequenced by MinION agreed with their expected concentration. No length or GC content bias was observed. The majority of cDNAs were sequenced as full length. Additionally, a complex cDNA population derived from a human HEK-293 cell line was sequenced on an Illumina HiSeq 2500, PacBio RS II and ONT MinION platforms. We observed that there was a good agreement in the measured cDNA abundance between PacBio RS II and ONT MinION (rpearson = 0.82, isoforms with length more than 700bp) and between Illumina HiSeq 2500 and ONT MinION (rpearson = 0.75). This indicates that the ONT MinION can sequence quantitatively both long and short full length cDNA molecules. PMID:27554526

  7. Benchmarking of the Oxford Nanopore MinION sequencing for quantitative and qualitative assessment of cDNA populations.

    Science.gov (United States)

    Oikonomopoulos, Spyros; Wang, Yu Chang; Djambazian, Haig; Badescu, Dunarel; Ragoussis, Jiannis

    2016-08-24

    To assess the performance of the Oxford Nanopore Technologies MinION sequencing platform, cDNAs from the External RNA Controls Consortium (ERCC) RNA Spike-In mix were sequenced. This mix mimics mammalian mRNA species and consists of 92 polyadenylated transcripts with known concentration. cDNA libraries were generated using a template switching protocol to facilitate the direct comparison between different sequencing platforms. The MinION performance was assessed for its ability to sequence the cDNAs directly with good accuracy in terms of abundance and full length. The abundance of the ERCC cDNA molecules sequenced by MinION agreed with their expected concentration. No length or GC content bias was observed. The majority of cDNAs were sequenced as full length. Additionally, a complex cDNA population derived from a human HEK-293 cell line was sequenced on an Illumina HiSeq 2500, PacBio RS II and ONT MinION platforms. We observed that there was a good agreement in the measured cDNA abundance between PacBio RS II and ONT MinION (rpearson = 0.82, isoforms with length more than 700bp) and between Illumina HiSeq 2500 and ONT MinION (rpearson = 0.75). This indicates that the ONT MinION can sequence quantitatively both long and short full length cDNA molecules.

  8. Benchmarking of the Oxford Nanopore MinION sequencing for quantitative and qualitative assessment of cDNA populations

    Science.gov (United States)

    Oikonomopoulos, Spyros; Wang, Yu Chang; Djambazian, Haig; Badescu, Dunarel; Ragoussis, Jiannis

    2016-01-01

    To assess the performance of the Oxford Nanopore Technologies MinION sequencing platform, cDNAs from the External RNA Controls Consortium (ERCC) RNA Spike-In mix were sequenced. This mix mimics mammalian mRNA species and consists of 92 polyadenylated transcripts with known concentration. cDNA libraries were generated using a template switching protocol to facilitate the direct comparison between different sequencing platforms. The MinION performance was assessed for its ability to sequence the cDNAs directly with good accuracy in terms of abundance and full length. The abundance of the ERCC cDNA molecules sequenced by MinION agreed with their expected concentration. No length or GC content bias was observed. The majority of cDNAs were sequenced as full length. Additionally, a complex cDNA population derived from a human HEK-293 cell line was sequenced on an Illumina HiSeq 2500, PacBio RS II and ONT MinION platforms. We observed that there was a good agreement in the measured cDNA abundance between PacBio RS II and ONT MinION (rpearson = 0.82, isoforms with length more than 700bp) and between Illumina HiSeq 2500 and ONT MinION (rpearson = 0.75). This indicates that the ONT MinION can sequence quantitatively both long and short full length cDNA molecules. PMID:27554526

  9. RECO level \\sqrt{s}_{min} and subsystem \\sqrt{s}_{min}: improved global inclusive variables for measuring the new physics mass scale in missing energy events at hadron colliders

    CERN Document Server

    Konar, Partha; Matchev, Konstantin T; Park, Myeonghun

    2010-01-01

    The variable \\sqrt{s}_{min} was originally proposed in arXiv:0812.1042 as a model-independent, global and fully inclusive measure of the new physics mass scale in missing energy events at hadron colliders. In the original incarnation of \\sqrt{s}_{min}, however, the connection to the new physics mass scale was blurred by the effects of the underlying event, most notably initial state radiation and multiple parton interactions. In this paper we advertize two improved variants of the \\sqrt{s}_{min} variable, which overcome this problem. First we show that by evaluating the \\sqrt{s}_{min} variable at the RECO level, in terms of the reconstructed objects in the event, the effects from the underlying event are significantly diminished and the nice correlation between the peak in the \\sqrt{s}_{min}^{(reco)} distribution and the new physics mass scale is restored. Secondly, the underlying event problem can be avoided altogether when the \\sqrt{s}_{min} concept is applied to a subsystem of the event which does not invo...

  10. Toward Spatially Regulated Division of Protocells: Insights into the E. coli Min System from in Vitro Studies

    Directory of Open Access Journals (Sweden)

    Simon Kretschmer

    2014-12-01

    Full Text Available For reconstruction of controlled cell division in a minimal cell model, or protocell, a positioning mechanism that spatially regulates division is indispensable. In Escherichia coli, the Min proteins oscillate from pole to pole to determine the division site by inhibition of the primary divisome protein FtsZ anywhere but in the cell middle. Remarkably, when reconstituted under defined conditions in vitro, the Min proteins self-organize into spatiotemporal patterns in the presence of a lipid membrane and ATP. We review recent progress made in studying the Min system in vitro, particularly focusing on the effects of various physicochemical parameters and boundary conditions on pattern formation. Furthermore, we discuss implications and challenges for utilizing the Min system for division site placement in protocells.

  11. Toward Spatially Regulated Division of Protocells: Insights into the E. coli Min System from in Vitro Studies.

    Science.gov (United States)

    Kretschmer, Simon; Schwille, Petra

    2014-01-01

    For reconstruction of controlled cell division in a minimal cell model, or protocell, a positioning mechanism that spatially regulates division is indispensable. In Escherichia coli, the Min proteins oscillate from pole to pole to determine the division site by inhibition of the primary divisome protein FtsZ anywhere but in the cell middle. Remarkably, when reconstituted under defined conditions in vitro, the Min proteins self-organize into spatiotemporal patterns in the presence of a lipid membrane and ATP. We review recent progress made in studying the Min system in vitro, particularly focusing on the effects of various physicochemical parameters and boundary conditions on pattern formation. Furthermore, we discuss implications and challenges for utilizing the Min system for division site placement in protocells. PMID:25513760

  12. Toward Spatially Regulated Division of Protocells: Insights into the E. coli Min System from in Vitro Studies

    OpenAIRE

    Simon Kretschmer; Petra Schwille

    2014-01-01

    For reconstruction of controlled cell division in a minimal cell model, or protocell , a positioning mechanism that spatially regulates division is indispensable. In Escherichia coli , the Min protein s oscillate from pole to pole to determine the division site by inhibition of the primary divisome protein FtsZ anywhere but in the cell middle. Remarkably, when reconstituted under defined conditions in vitro , the Min proteins self - organize into spatiotem poral patterns in the presence of a ...

  13. The MoCA 5-min protocol is a brief, valid, reliable and feasible cognitive screen for telephone administration

    Science.gov (United States)

    Wong, Adrian; Nyenhuis, David; Black, Sandra E; Law, Lorraine S.N.; Lo, Eugene S.K.; Kwan, Pauline W.L.; Au, Lisa; Chan, Anne YY; Wong, Lawrence KS; Nasreddine, Ziad; Mok, Vincent

    2015-01-01

    Background and Purpose The NINDS-CSN vascular cognitive impairment (VCI) Harmonization working group proposed a brief cognitive protocol for screening of VCI. We investigated the validity, reliability and feasibility of the Montreal Cognitive Assessment 5-minute protocol (MoCA 5-min protocol) administered over the telephone. Methods Four items examining attention, verbal learning and memory, executive functions/language and orientation were extracted from the MoCA to form the MoCA 5-min protocol. One hundred and four patients with stroke or TIA, including 53 with normal cognition (CDR 0) and 51 with cognitive impairment (CDR 0.5 or 1), were administered the MoCA in clinic and a month later, the MoCA 5-min protocol over the telephone. Results Administration of the MoCA 5-min protocol took five minutes over the telephone. Total score of the MoCA 5-min protocol correlated negatively with age (r=-0.36, p0.05 for difference; Cohen's d for group difference 0.801.13). It differentiated cognitively impaired patients with executive domain impairment from those without (AUC=0.89, p<0.001; Cohen's d=1.7 for group difference). 30-day test-retest reliability was excellent (Intraclass correlation coefficient=0.89). Conclusions The MoCA 5-min protocol is a free, valid and reliable cognitive screen for stroke and TIA. It is brief and highly feasible for telephone administration. PMID:25700290

  14. A novel approach to assess the spontaneous gastrointestinal bleeding risk of antithrombotic agents using Apc(min/+) mice.

    Science.gov (United States)

    Wei, Huijun; Shang, Jin; Keohane, CarolAnn; Wang, Min; Li, Qiu; Ni, Weihua; O'Neill, Kim; Chintala, Madhu

    2014-06-01

    Assessment of the bleeding risk of antithrombotic agents is usually performed in healthy animals with some form of vascular injury to peripheral organs to induce bleeding. However, bleeding observed in patients with currently marketed antithrombotic drugs is typically spontaneous in nature such as intracranial haemorrhage (ICH) and gastrointestinal (GI) bleeding, which happens most frequently on top of preexisting pathologies such as GI ulcerations and polyps. Apc(min/+) mice are reported to develop multiple adenomas through the entire intestinal tract and display progressive anaemia.In this study, we evaluated the potential utility of Apc(min/+) mice as a model for assessing spontaneous GI bleeding with antithrombotic agents. Apc(min/+) mice exhibited progressive blood loss starting at the age of nine weeks. Despite the increase in bleeding, Apc(min/+) mice were in a hypercoagulable state and displayed an age-dependent increase in thrombin generation and circulating fibrinogen as well as a significant decrease in clotting times. We evaluated the effect of warfarin, dabigatran etexilate, apixaban and clopidogrel in this model by administering them in diet or in the drinking water to mice for 1-4 weeks. All of these marketed drugs significantly increased GI bleeding in Apc(min/+) mice, but not in wild-type mice. Although different exposure profiles of these antithrombotic agents make it challenging to compare the bleeding risk of compounds, our results indicate that the Apc(min/+) mouse may be a sensitive preclinical model for assessing the spontaneous GI bleeding risk of novel antithrombotic agents.

  15. Mammary tumorigenesis in APC{sup min/+} mice is enhanced by X-irradiation with a characteristic age dependence

    Energy Technology Data Exchange (ETDEWEB)

    Tatsuhiko, Imaoka; Mayumi, Nishimura; Shizuko, Kakinuma; Yoshiya, Shimada [National Institute of Radiological Sciences, Experimental Radiobiology for Children' s Health Research Group, Research, Center for Radiation Protection (Japan); Mieko, Okamoto [Tokyo Metropolitan Institute of Medical Science (Japan)

    2006-07-01

    The ApcM{sup min/+} (Min) mouse is a genetically predisposed model of both intestinal and mammary tumorigenesis. We investigated age-related changes in the susceptibility of mice (before, during and after puberty) to radiation-induced mammary tumorigenesis using this model. Female Min and wild-type mice having the C57BL/6J background were irradiated with 2 Gy of X-rays at 2, 5, 7 and 10 weeks and sacrificed at 18 weeks of age. Min mice irradiated at 7 to 10 weeks of age (after puberty) developed mammary tumors with squamous metaplasia, whereas their wild-type litter-mates did not. Interestingly, irradiation of Min mice at 2 to 5 weeks (before and during puberty, respectively) did not induce mammary tumors but rather cystic nodules with metaplasia. The mammary tumors exhibited increased nuclear beta-catenin protein and loss of the wild-type Apc allele. Our results show that susceptibility to radiation-induced mammary tumorigenesis increases after puberty in Min mice, suggesting that the tumorigenic effect of ionizing radiation targets the lobular-alveolar progenitor cells, which increase in number with age and are controlled by beta-catenin signaling. (author)

  16. Interaction of sulfonylurea-conjugated polymer with insulinoma cell line of MIN6 and its effect on insulin secretion.

    Science.gov (United States)

    Park, K H; Kim, S W; Bae, Y H

    2001-04-01

    A carboxylated derivative of sulfonylurea (SU), an insulinotropic agent, was synthesized and grafted onto a water-soluble polymer as a biospecific and stimulating polymer for insulin secretion. To evaluate the effect of the SU-conjugated polymer on insulin secretion, its solution in dimethyl sulfoxide was added to the culture of insulinoma cell line of MIN6 cells to make 10 nM of SU units in the medium and incubated for 3 h at 37 degrees C. The culture medium was conditioned with glucose concentration of 3.3 or 25 mM. To verify the specific interaction between the SU (K+ channel closer)-conjugated polymer and MIN6 cells, the cells were pretreated with diazoxide, an agonist of adenosine triphosphate-sensitive K+ channel (K+ channel opener), before adding the SU-conjugated polymer to the cell culture medium. This treatment suppressed the action of SUs on MIN6 cells. Fluorescence-labeled polymer with rodamine-B isothiocyanate was used to visualize the interactions, and we found that the labeled polymer strongly absorbed to MIN6 cells, probably owing to its specific interaction mediated by SU receptors on the cell membrane. The fluorescence intensity on the cells significantly increased with an increase in incubation time and polymer concentration. A confocal laser microscopic study further confirmed this interaction. The results from this study provided evidence that SU-conjugated copolymer stimulates insulin secretion by specific interactions of SU moieties in the polymer with MIN6 cells.

  17. Phenotypic and gene expression changes between low (glucose-responsive) and High (glucose non-responsive) MIN-6 beta cells

    DEFF Research Database (Denmark)

    O´Driscoll, L.; Gammell, p.; McKierman, E.;

    2006-01-01

    The long-term potential to routinely use replacement beta cells/islets as cell therapy for type 1 diabetes relies on our ability to culture such cells/islets, in vitro, while maintaining their functional status. Previous beta cell studies, by ourselves and other researchers, have indicated......-potential), poorly differentiated, 'precursor-like' cell type. This observation is supported by increased expression of the stem cell marker, alkaline phosphatase...... that the glucose-stimulated insulin secretion (GSIS) phenotype is relatively unstable, in long-term culture. This study aimed to investigate phenotypic and gene expression changes associated with this loss of GSIS, using the MIN-6 cell line as model. Phenotypic differences between MIN-6(L, low passage) and MIN-6(H...

  18. Measurement of left ventricular ejection fraction with ionic sup(113m)In and a cardiac probe

    International Nuclear Information System (INIS)

    Left ventricular ejection fraction (LVEF) was measured with a cardiac probe (Nuclear Stethoscope. Bios Inc., Valhalla, New York) and sup(113m)In in 28 normal subjects and 86 patients with coronary artery disease (CAD). In 20 normal subjects sup(99m)TC-RBCs were compared with sup(113m)In, which binds to transferrin after IV injection. With sup(99m)Tc-RBCs average LVEF was 57+-7% (1 SD); with sup(113m)In, average LEVF was 55+-8% (N.S.). Sequential measurements at different times over 60 min revealed good reproducibility. Comparison of LVEF's obtained using sup(99m)Tc-RBCs with a gamma camera and cardiac probe revealed a good correlation. The correlation coefficients were 0.92 in 25 patients with CAD and 0.95 in 10 patients with LV wall motion abnormalities. The LVEF obtained using a cardiac probe and sup(113m)In increased in 28 normals from 57+-9% to 64+-13% (P<0.001) during handgrip exercise, while the LVEF decreased from 45+-9% to 41+-10% (P<0.01) in patients with acute myocardial infarction 4-7 weeks after episode, from 48+-11 to 40+-12% (P<0.001) in patients with old myocardial infarction, and from 52+-9 to 42+-9% (P<0.001) in patients with angina pectoris. The cardiac probe and sup(113m)In provide a useful alternate means of determining left ventricular dysfunction in facilities where sup(99m)Tc and a gamma camera computer system are not readily available. (orig.)

  19. Gynekologisen syövän sairastaneiden kokemuksia sairauden vaikutuksista seksuaalisuuteen ja minäkuvaan

    OpenAIRE

    Liimatainen, Sanja; Hämäläinen, Tiia

    2015-01-01

    Gynekologinen syöpä ja sen hoidot vaikuttavat useimmiten merkittävästi naisen minäkuvaan ja seksuaalisuuteen. Sijainniltaan gynekologinen syöpä on lähellä seksuaalisuuteen liittyviä elimiä ja seksitoimintoja, jolloin sen merkitys seksuaalisuudelle korostuu. Sairauden tuomat mahdolliset muutokset vaikuttavat myös minäkuvaan, jolloin käsitykset itsestä useimmiten muokkaantuvat. Opinnäytetyön tarkoituksena oli kartoittaa sairauden merkityksellisyyttä ja sen mahdollisesti aiheuttamia vaikutuk...

  20. Astrobiological Significance of Definitive Mineralogical Analysis of Martian Surface Samples Using the CheMin XRD/XRF Instrument

    Science.gov (United States)

    Feldman, S. M.; Blake, D. F.; Sarrazin, P.; Bish, D. L.; Chipera, S. J.; Vaniman, D. T.; Collins, S.

    2004-01-01

    The search for evidence of habitability, or of extant or extinct life on Mars, will initially be a search for evidence of past or present conditions supportive of life. The three key requirements for the emergence of life are thought to be liquid water; a suitable energy source; and chemical building blocks. CheMin is a miniaturized XRD/XRF (X-Ray diffraction / X-ray fluorescence) instrument which has been developed for definitive mineralogic analysis of soils and rocks on the Martian surface. The CheMin instrument can provide information that is highly relevant to each of these habitability requirements as summarized below.

  1. Influence of min-a-zel plus and maize meal addition on the quality of lucerne silage

    Directory of Open Access Journals (Sweden)

    Đorđević Nenad 1

    2004-01-01

    Full Text Available The influence of mineral adsorbent Min-A-Zel Plus (5 g/kg and maize meal (25 and 50 g/kg used alone or combined, on chemical composition, biochemical changes and quality of lucerne silage was investigated. Based on the obtained data, it can be concluded that addition of Min-A-Zel Plus reduces aminogenesis, while the use of maize meal alone or with zeolite favorable conditions are achieved for lactic acid fermentation, so that the quality of obtained silages is better by one quality class. To achieve better effects of silage quality, the use of combination of mineral adsorbent with carbohydrate additives is recommended.

  2. Effective photoexcitation cross section of 115In(γ,γ′115mIn from photoactivation data

    Directory of Open Access Journals (Sweden)

    Versteegen M.

    2016-01-01

    Full Text Available Photoexcitation yields of the 115mIn metastable state were measured with Bremsstrahlung γ beams over a range of endpoint energies between 4.5 and 18 MeV. An effective cross section of the 115In(γ,γ′115mIn photoexcitation cross section was determinedto reproduce the data. This cross section is built from a cross section calculated with the TALYS code, to which an enhancement is added at about 8.5 MeV.

  3. Miniature X-Ray Solar Spectrometer (MinXSS) - A Science-Oriented, University 3U CubeSat

    OpenAIRE

    Mason, James P.; Woods, Thomas N.; Caspi, Amir; Chamberlin, Phillip C.; Moore, Christopher; Jones, Andrew; Kohnert, Rick; Li, Xinlin; Palo, Scott; Solomon, Stanley

    2015-01-01

    The Miniature X-ray Solar Spectrometer (MinXSS) is a 3-Unit (3U) CubeSat developed at the Laboratory for Atmospheric and Space Physics (LASP) at the University of Colorado, Boulder (CU). Over 40 students contributed to the project with professional mentorship and technical contributions from professors in the Aerospace Engineering Sciences Department at CU and from LASP scientists and engineers. The scientific objective of MinXSS is to study processes in the dynamic Sun, from quiet-Sun to sol...

  4. Streaming algorithms for identification of pathogens and antibiotic resistance potential from real-time MinION(TM) sequencing.

    Science.gov (United States)

    Cao, Minh Duc; Ganesamoorthy, Devika; Elliott, Alysha G; Zhang, Huihui; Cooper, Matthew A; Coin, Lachlan J M

    2016-07-26

    The recently introduced Oxford Nanopore MinION platform generates DNA sequence data in real-time. This has great potential to shorten the sample-to-results time and is likely to have benefits such as rapid diagnosis of bacterial infection and identification of drug resistance. However, there are few tools available for streaming analysis of real-time sequencing data. Here, we present a framework for streaming analysis of MinION real-time sequence data, together with probabilistic streaming algorithms for species typing, strain typing and antibiotic resistance profile identification. Using four culture isolate samples, as well as a mixed-species sample, we demonstrate that bacterial species and strain information can be obtained within 30 min of sequencing and using about 500 reads, initial drug-resistance profiles within two hours, and complete resistance profiles within 10 h. While strain identification with multi-locus sequence typing required more than 15x coverage to generate confident assignments, our novel gene-presence typing could detect the presence of a known strain with 0.5x coverage. We also show that our pipeline can process over 100 times more data than the current throughput of the MinION on a desktop computer.

  5. An Optimal Free Energy Dissipation Strategy of the MinCDE Oscillator in Regulating Symmetric Bacterial Cell Division.

    Directory of Open Access Journals (Sweden)

    Liping Xiong

    2015-08-01

    Full Text Available Sustained molecular oscillations are ubiquitous in biology. The obtained oscillatory patterns provide vital functions as timekeepers, pacemakers and spacemarkers. Models based on control theory have been introduced to explain how specific oscillatory behaviors stem from protein interaction feedbacks, whereas the energy dissipation through the oscillating processes and its role in the regulatory function remain unexplored. Here we developed a general framework to assess an oscillator's regulation performance at different dissipation levels. Using the Escherichia coli MinCDE oscillator as a model system, we showed that a sufficient amount of energy dissipation is needed to switch on the oscillation, which is tightly coupled to the system's regulatory performance. Once the dissipation level is beyond this threshold, unlike stationary regulators' monotonic performance-to-cost relation, excess dissipation at certain steps in the oscillating process damages the oscillator's regulatory performance. We further discovered that the chemical free energy from ATP hydrolysis has to be strategically assigned to the MinE-aided MinD release and the MinD immobilization steps for optimal performance, and a higher energy budget improves the robustness of the oscillator. These results unfold a novel mode by which living systems trade energy for regulatory function.

  6. Establishment of clonal MIN-O transplant lines for molecular imaging via lentiviral transduction & in vitro culture.

    Directory of Open Access Journals (Sweden)

    David L Boucher

    Full Text Available As the field of molecular imaging evolves and increasingly is asked to fill the discovery and validation space between basic science and clinical applications, careful consideration should be given to the models in which studies are conducted. The MIN-O mouse model series is an established in vivo model of human mammary precancer ductal carcinoma in situ with progression to invasive carcinoma. This series of transplant lines is propagated in vivo and experiments utilizing this model can be completed in non-engineered immune intact FVB/n wild type mice thereby modeling the tumor microenvironment with biological relevance superior to traditional tumor cell xenografts. Unfortunately, the same qualities that make this and many other transplant lines more biologically relevant than standard cell lines for molecular imaging studies present a significant obstacle as somatic genetic re-engineering modifications common to many imaging applications can be technically challenging. Here, we describe a protocol for the efficient lentiviral transduction of cell slurries derived from precancerous MIN-O lesions, in vitro culture of "MIN-O-spheres" derived from single cell clones, and the subsequent transplantation of these spheres to produce transduced sublines suitable for optical imaging applications. These lines retain the physiologic and pathologic properties, including multilineage differentiation, and complex microanatomic interaction with the host stroma characteristic of the MIN-O model. We also present the in vivo imaging and immunohistochemical analysis of serial transplantation of one such subline and detail the progressive multifocal loss of the transgene in successive generations.

  7. Influence of Caffeine Ingestion on Perceived Mood States, Concentration, and Arousal Levels during a 75-Min University Lecture

    Science.gov (United States)

    Peeling, Peter; Dawson, Brian

    2007-01-01

    This investigation aimed to assess the effect of a caffeine supplement on perceived mood state, concentration, and arousal during a 75-min university lecture. Methods. This randomized, blind, cross-over design investigation ran over a course of 2 consecutive weeks. During "week" 1, 10 third-year Human Movement and Exercise Science students were…

  8. Min小鼠疾病"一体化"模型%Integrative model of Min mouse for diseases

    Institute of Scientific and Technical Information of China (English)

    胡烨婷; 陆艺; 赵寒昕; 盛弘强

    2011-01-01

    Min (multiple intestinal neoplasia) mouse is widely considered as the appropriate model of human familial adenomatous polyposis (familial adenrnatous polyposis, FAP) because of hearing multiple intestinal polyps, Thus, the mechanism on intestinal carcinogenesis is highly concerned.In addition,marked splenomegaly and typical anemia will be present,accompanied by a distinct decline in hematocrit.Min mice also have other obvious symptoms such as tyymus trophy.The reproductive and endocrine system will lead to be obviously abnormal once treated with carcinogenic agent(e.g.ENU) in the female Min mice.Since the phenotype is clear,Min mouse could be developed into an integrative model based on its wide range of phenotypic characteristics.The present review introduced the pathological symptoms of various systems in Min mice to clarify the new concept on the integrative model.%Min基因突变小鼠因其肠道多发息肉被认为是人类家族性腺瘤性息肉病(FAP)的理想模型,在肠道肿瘤发生机制方面备受关注,其具有典型的贫血表现,脾肿大明显,同时伴有血细胞比容的明显下降.Min小鼠还具有明显的胸腺萎缩等症状.此外,雌性小鼠如经致癌剂ENU诱导,易发生生殖与内分泌系统异常.由于该小鼠表型明确,可以利用其多种表型特征开展疾病"一体化"模型研究.本文主要从Min小鼠在多个系统表现出来的不同病理特征来进行文献综述并深人阐述"一体化"模型.

  9. Voluntary exercise inhibits intestinal tumorigenesis in ApcMin/+ mice and azoxymethane/dextran sulfate sodium-treated mice

    International Nuclear Information System (INIS)

    Epidemiological studies suggest that physical activity reduces the risk of colon cancer in humans. Results from animal studies, however, are inconclusive. The present study investigated the effects of voluntary exercise on intestinal tumor formation in two different animal models, ApcMin/+ mice and azoxymethane (AOM)/dextran sulfate sodium (DSS)-treated mice. In Experiments 1 and 2, five-week old female ApcMin/+ mice were either housed in regular cages or cages equipped with a running wheel for 6 weeks (for mice maintained on the AIN93G diet; Experiment 1) or 9 weeks (for mice on a high-fat diet; Experiment 2). In Experiment 3, male CF-1 mice at 6 weeks of age were given a dose of AOM (10 mg/kg body weight, i.p.) and, 12 days later, 1.5% DSS in drinking fluid for 1 week. The mice were then maintained on a high-fat diet and housed in regular cages or cages equipped with a running wheel for 16 weeks. In the ApcMin/+ mice maintained on either the AIN93G or the high-fat diet, voluntary exercise decreased the number of small intestinal tumors. In the AOM/DSS-treated mice maintained on a high-fat diet, voluntary exercise also decreased the number of colon tumors. In ApcMin/+ mice, voluntary exercise decreased the ratio of serum insulin like growth factor (IGF)-1 to IGF binding protein (BP)-3 levels. It also decreased prostaglandin E2 and nuclear β-catenin levels, but increased E-cadherin levels in the tumors. These results indicate hat voluntary exercise inhibited intestinal tumorigenesis in ApcMin/+ mice and AOM/DSS-treated mice, and the inhibitory effect is associated with decreased IGF-1/IGFBP-3 ratio, aberrant β-catenin signaling, and arachidonic acid metabolism

  10. A facile synthesis of MInSe2 (M = Cu, Ag) via low temperature pyrolysis of single source molecular precursors, [(R3P)2MIn(SeCOAr)4

    Indian Academy of Sciences (India)

    Shamik Ghoshal; Liladhar B Kumbhare; Vimal K Jain; Gautam K Dey

    2007-04-01

    The reaction of KSeCOAr with InCl3 and [MCl(PR3)2] in benzene afforded bimetallic complexes, [(R3P)2MIn(SeCOAr)4] (PR3 = PEt3 or PPh3; M = Cu or Ag; Ar = –C6H5 (phenyl) or 4-MeC6H4 (tolyl)). The triethylphosphine complexes decomposed rapidly when M = Ag while slowly when M = Cu. All these complexes were characterized by elemental analysis, IR, UV-VIS, NMR (1H, 31P) spectral data. Pyrolysis in a furnace at 300°C gave tetragonal MInSe2 (M = Cu, Ag) structure. Solvothermal decomposition of [(PPh3)2CuIn(SeCOAr)4] in boiling ethylene glycol gave nanorods of CuInSe2 which were characterized by XRD, EDAX, SEM and TEM.

  11. Science Goals and First Light Analysis from the Miniature X-ray Solar Spectrometer (MinXSS) CubeSat

    Science.gov (United States)

    Caspi, Amir; Woods, Thomas N.; Warren, Harry; Chamberlin, Phillip C.; Jones, Andrew; Mason, James; McTiernan, James; Moore, Christopher; Palo, Scott; Solomon, Stanley

    2016-05-01

    The Miniature X-ray Solar Spectrometer (MinXSS) is a 3U CubeSat with deployment from the ISS planned in Q2 2016. Its goal is to measure the solar soft X-ray (SXR) spectral irradiance, an observational signature of hot plasma in the solar corona. Over the last few decades, there have been very few spectrally resolved observations from ~0.2 to ~4 keV (~0.3-6 nm). This range is sensitive to high-temperature plasma and contains many spectral lines (e.g., Mg, Si, Fe, S, Ar), the abundances of which probe plasma transport and provide valuable constraints on plasma heating mechanisms during both flares and quiescence. This solar SXR emission is primarily absorbed in the E-region of Earth's ionosphere, and the subsequently driven dynamical processes are still poorly understood, in large part because the energy distribution of the incident SXRs is not yet well characterized.MinXSS flies a miniature commercial off-the-shelf soft X-ray (SXR) spectrometer, the Amptek X123-SDD. The silicon drift detector has 0.5 mm fully depleted thickness and a 25 mm^2 physical area, with a ~16 micron Be entrance window; with on-board thermoelectric cooling and pulse pile-up rejection, it is sensitive to solar SXRs from ~0.5 to 30 keV with ~0.15 keV FWHM resolution. MinXSS also includes a broadband SXR photometer, providing an integrated intensity over a similar energy range for comparison, cross-calibration, and additional data, especially useful during more intense flares at the upper end of the X123 dynamic range.We present the MinXSS science goals for studying hot plasma in the solar corona, including impulsive flare heating and quiescent coronal heating, and the impact of the resultant SXR emission on Earth's ionosphere, thermosphere, and mesosphere. We present analysis of MinXSS first light results (depending on deployment date from the ISS), as well as modeling and predictions of future observations over the MinXSS 6-12 month mission lifetime.

  12. Se min pizzabolle!

    DEFF Research Database (Denmark)

    Hoffmeyer, Mikkeline; Brandt, Karen Merete

    2014-01-01

    Emne: Hvordan kan vi udvikle digitale læringsdesigns, der styrker visuelle, sproglige, æstetiske og kommunikative kompetencer i fagene dansk og billedkunst? Metode og baggrund: Ovenstående har været omdrejningspunkt i vores udviklingsarbejde, som har haft afsæt i sociosemiotisk forskning omkring ...

  13. Se min kropsholder

    DEFF Research Database (Denmark)

    Hansen, Lone Koefoed; Staunsager, Sara

    2015-01-01

    Også kønnet kan være en forandringsagent. Med stolen Hustruen som konkret metafor diskuterer artiklen, hvordan den kvindelige designforening Rundkant tager strategisk og kunstnerisk afsæt i kvindekampens og kvindekønnets historie og samtid, når medlemmerne søger at mestre kunsten som ung (kvindel...

  14. Min Morfars Film

    DEFF Research Database (Denmark)

    Juel, Henrik

    1957-01-01

    Reflektioner over filmhistoriebegrebet og gennemgang af konkrete filmoplevelser i 1957 og i nutiden med udgangspunkt i mødet med en gammel familiefilm. Reflektioner over valg af motiver i en social- og personhistorisk dateret film.......Reflektioner over filmhistoriebegrebet og gennemgang af konkrete filmoplevelser i 1957 og i nutiden med udgangspunkt i mødet med en gammel familiefilm. Reflektioner over valg af motiver i en social- og personhistorisk dateret film....

  15. Min-max optimization and the radial approach to the public service system design with generalized utility

    Directory of Open Access Journals (Sweden)

    Jaroslav Janáček

    2016-04-01

    Full Text Available The paper deals with the min-max public service system design, where the generalized utility is considered. In contrast to the formulations presented in the literature, the generalized utility defined for a public service system assumes that the user’s utility comes generally from more than one located service center and the individual contributions from relevant centers are weighted by reduction coefficients depending on a center order. Given that commercial IP-solvers often fail due to enormous computational times or extreme memory demands when resolving this issue, we suggested and compared several approaches based on a bisection process with the purpose of developing an effective max-min approach to the public service system design with a generalized utility.

  16. Polynomial Time Algorithm for Determining Max-Min Paths in Networks and Solving Zero Value Cyclic Games

    Directory of Open Access Journals (Sweden)

    Dmitrii D. Lozovanu

    2005-10-01

    Full Text Available We study the max-min paths problem, which represents a game version of the shortest and the longest paths problem in a weighted directed graph. In this problem the vertex set V of the weighted directed graph G=(V,E is divided into two disjoint subsets VA and VB which are regarded as positional sets of two players. The players are seeking for a directed path from the given starting position ν 0 to the final position ν f , where the first player intends to maximize the integral cost of the path while the second one has aim to minimize it. Polynomial-time algorithm for determining max-min path in networks is proposed and its application for solving zero value cyclic games is developed. Mathematics Subject Classification 2000: 90B10, 90C35, 90C27.

  17. Experimental and Monte Carlo study on production of 110mIn via natCd(p,xn) reaction

    International Nuclear Information System (INIS)

    110mIn with 69.1 min half-life was produced by proton bombardment on natural cadmium. The target was prepared by electroplating technique. To reach a high activity product, the optimum energy range of the irradiation was selected to be 15-5 MeV via theoretical calculation. Radiochemical separation of cadmium and indium was carried out by extraction method. It yielded 44.3 ± 8.8 GBq C-1 after 1 hour irradiation by 100 μA current. On the other hand, the production route was simulated using MCNPX and the production yield was estimated with a reasonable agreement compared to the measured and literature data. (author)

  18. Chemopreventive Effects of RXR-Selective Rexinoid Bexarotene on Intestinal Neoplasia of ApcMin/+ Mice1

    OpenAIRE

    Janakiram, Naveena B; Mohammed, Altaf; Qian, Li; Choi, Chang-In; Steele, Vernon E.; Rao, Chinthalapally V.

    2012-01-01

    Retinoid X receptor (RXR) has been implicated in several neoplastic diseases. Previously, we have shown that RXR-α is downregulated in human and rodent colonic tumors, suggesting a potential target for colon cancer prevention (http://www.cancer.org/Cancer/ColonandRectumCancer/DetailedGuide/colorectal-cancer-key-statistics). Experiments were designed to assess the chemopreventive efficacy of the selective RXR agonist bexarotene for the suppression of intestinal tumorigenesis in ApcMin/+ mice. ...

  19. Min-max optimization and the radial approach to the public service system design with generalized utility

    OpenAIRE

    Jaroslav Janáček; Marek Kvet

    2016-01-01

    The paper deals with the min-max public service system design, where the generalized utility is considered. In contrast to the formulations presented in the literature, the generalized utility defined for a public service system assumes that the user’s utility comes generally from more than one located service center and the individual contributions from relevant centers are weighted by reduction coefficients depending on a center order. Given that commercial IP-solvers often fail due to enor...

  20. Maslinic acid-enriched diet decreases intestinal tumorigenesis in Apc(Min/+ mice through transcriptomic and metabolomic reprogramming.

    Directory of Open Access Journals (Sweden)

    Susana Sánchez-Tena

    Full Text Available Chemoprevention is a pragmatic approach to reduce the risk of colorectal cancer, one of the leading causes of cancer-related death in western countries. In this regard, maslinic acid (MA, a pentacyclic triterpene extracted from wax-like coatings of olives, is known to inhibit proliferation and induce apoptosis in colon cancer cell lines without affecting normal intestinal cells. The present study evaluated the chemopreventive efficacy and associated mechanisms of maslinic acid treatment on spontaneous intestinal tumorigenesis in Apc(Min/+ mice. Twenty-two mice were randomized into 2 groups: control group and MA group, fed with a maslinic acid-supplemented diet for six weeks. MA treatment reduced total intestinal polyp formation by 45% (P<0.01. Putative molecular mechanisms associated with suppressing intestinal polyposis in Apc(Min/+ mice were investigated by comparing microarray expression profiles of MA-treated and control mice and by analyzing the serum metabolic profile using NMR techniques. The different expression phenotype induced by MA suggested that it exerts its chemopreventive action mainly by inhibiting cell-survival signaling and inflammation. These changes eventually induce G1-phase cell cycle arrest and apoptosis. Moreover, the metabolic changes induced by MA treatment were associated with a protective profile against intestinal tumorigenesis. These results show the efficacy and underlying mechanisms of MA against intestinal tumor development in the Apc(Min/+ mice model, suggesting its chemopreventive potential against colorectal cancer.

  1. Assessing the utility of the Oxford Nanopore MinION for snake venom gland cDNA sequencing.

    Science.gov (United States)

    Hargreaves, Adam D; Mulley, John F

    2015-01-01

    Portable DNA sequencers such as the Oxford Nanopore MinION device have the potential to be truly disruptive technologies, facilitating new approaches and analyses and, in some cases, taking sequencing out of the lab and into the field. However, the capabilities of these technologies are still being revealed. Here we show that single-molecule cDNA sequencing using the MinION accurately characterises venom toxin-encoding genes in the painted saw-scaled viper, Echis coloratus. We find the raw sequencing error rate to be around 12%, improved to 0-2% with hybrid error correction and 3% with de novo error correction. Our corrected data provides full coding sequences and 5' and 3' UTRs for 29 of 33 candidate venom toxins detected, far superior to Illumina data (13/40 complete) and Sanger-based ESTs (15/29). We suggest that, should the current pace of improvement continue, the MinION will become the default approach for cDNA sequencing in a variety of species. PMID:26623194

  2. Transfer of a eubacteria-type cell division site-determining factor CrMinD gene to the nucleus from the chloroplast genome in Chlamydomonas reinhardtii

    Institute of Scientific and Technical Information of China (English)

    LIU WeiZhong; HU Yong; ZHANG RunJie; ZHOU WeiWei; ZHU JiaYing; LIU XiangLin; HE YiKun

    2007-01-01

    MinD is a ubiquitous ATPase that plays a crucial role in selection of the division site in eubacteria, chloroplasts, and probably Archaea. In four green algae, Mesostigma viride, Nephroselmis olivacea, Chlorella vulgaris and Prototheca wickerhamii, MinD homologues are encoded in the plastid genome. However, in Arabidopsis, MinD is a nucleus-encoded, chloroplast-targeted protein involved in chloroplast division, which suggests that MinD has been transferred to the nucleus in higher land plants. Yet the lateral gene transfer (LGT) of MinD from plastid to nucleus during plastid evolution remains poorly understood. Here, we identified a nucleus-encoded MinD homologue from unicellular green alga Chlamydomonas reinhardtii, a basal species in the green plant lineage. Overexpression of CrMinD in wild type E. coli inhibited cell division and resulted in the filamentous cell formation, clearly demonstrated the conservation of the MinD protein during the evolution of photosynthetic eukaryotes. The transient expression of CrMinD-egfp confirmed the role of CrMinD protein in the regulation of plastid division. Searching all the published plastid genomic sequences of land plants, no MinD homologues were found, which suggests that the transfer of MinD from plastid to nucleus might have occurred before the evolution of land plants.

  3. Krüppel-like factor 5 is a crucial mediator of intestinal tumorigenesis in mice harboring combined ApcMin and KRASV12 mutations

    Directory of Open Access Journals (Sweden)

    Robine Sylvie

    2010-03-01

    Full Text Available Abstract Background Both mutational inactivation of the adenomatous polyposis coli (APC tumor suppressor gene and activation of the KRAS oncogene are implicated in the pathogenesis of colorectal cancer. Mice harboring a germline ApcMin mutation or intestine-specific expression of the KRASV12 gene have been developed. Both mouse strains develop spontaneous intestinal tumors, including adenoma and carcinoma, though at a different age. The zinc finger transcription factor Krüppel-like factor 5 (KLF5 has previously been shown to promote proliferation of intestinal epithelial cells and modulate intestinal tumorigenesis. Here we investigated the in vivo effect of Klf5 heterozygosity on the propensity of ApcMin/KRASV12 double transgenic mice to develop intestinal tumors. Results At 12 weeks of age, ApcMin/KRASV12 mice had three times as many intestinal tumors as ApcMin mice. This increase in tumor number was reduced by 92% in triple transgenic ApcMin/KRASV12/Klf5+/- mice. The reduction in tumor number in ApcMin/KRASV12/Klf5+/- mice was also statistically significant compared to ApcMin mice alone, with a 75% decrease. Compared with ApcMin/KRASV12, tumors from both ApcMin/KRASV12/Klf5+/- and ApcMin mice were smaller. In addition, tumors from ApcMin mice were more distally distributed in the intestine as contrasted by the more proximal distribution in ApcMin/KRASV12 and ApcMin/KRASV12/Klf5+/- mice. Klf5 levels in the normal-appearing intestinal mucosa were higher in both ApcMin and ApcMin/KRASV12 mice but were attenuated in ApcMin/KRASV12/Klf5+/- mice. The levels of β-catenin, cyclin D1 and Ki-67 were also reduced in the normal-appearing intestinal mucosa of ApcMin/KRASV12/Klf5+/- mice when compared to ApcMin/KRASV12 mice. Levels of pMek and pErk1/2 were elevated in the normal-appearing mucosa of ApcMin/KRASV12 mice and modestly reduced in ApcMin/KRASV12/Klf5+/- mice. Tumor tissues displayed higher levels of both Klf5 and β-catenin, irrespective of the

  4. Aldosterone-induced apoptosis of MIN6 cells and its mechanism%醛固酮诱导MIN6细胞凋亡及作用机制研究

    Institute of Scientific and Technical Information of China (English)

    潘瑜; 刘晓莉; 束金莲; 张霞; 金惠敏

    2012-01-01

    Objective To investigate the effects of aldosterone on apoptosis of tnurine pancreatic islets B cell line MIN6, and explore its possible mechanism. Methods Murine pancreatic islets B cell line MIN6 cultured in vitro was divided into control group (treated with serum-free DMEM culture medium), aldosterone group (treated with 10, 100 or 1 000 nmol/L aldosterone) and aldosterone + aldosterone antagonist group ( treated with 100 nmol/L aldosterone and 100 nmol/L aldactone). Cell viability was determined by MTT assay, glucose-stimulated insulin secretion ( GSIS) was measured by radioimmunoassay, cell apoptosis was detected by flow cytometry in combination with FITC-Annexin V/PI fluorescein staining, Caspase-3 activity in supernatant of culture fluid was determined by ELISA, and the expression of apoptosis-related proteins of cytochrome C(Cyt-C), Bcl-2, Bax and phosphorylated protein kinase C ( p-Akt) was detected by Western blotting. Results The viability of MIN6 cells decreased with the increase of concentrations of aldosterone, with a concentration-dependent manner. Under physical glucose concentration (5.6 mmol/L) and high glucose concentration (28 mmol/L) environment, GSIS of aldosterone group was significantly lower than that of control group ( P <0. 01), and GSIS of aldosterone + aldosterone antagonist group was significantly higher than that of aldosterone group ( P < 0. 01). The cell apoptosis ratio of aldosterone group was significantly higher than that of control group ( P <0.01), and the cell apoptosis ratio of aldosterone + aldosterone antagonist group was significantly lower than that of aldosterone group (P < 0. 01). Compared with control group, the Caspase-3 activity and expression of Cyt-C were significantly higher, and Bcl-2/ Bax and the expression of p-Akt were significantly lower ( P < 0. 01 for all), while aldosterone antagonist significantly inhibited aldosterone-mediated Caspase-3 activity increase and abnormal expression of related proteins

  5. The regulation of skeletal muscle protein turnover during the progression of cancer cachexia in the Apc(Min/+ mouse.

    Directory of Open Access Journals (Sweden)

    James P White

    Full Text Available Muscle wasting that occurs with cancer cachexia is caused by an imbalance in the rates of muscle protein synthesis and degradation. The Apc(Min/+ mouse is a model of colorectal cancer that develops cachexia that is dependent on circulating IL-6. However, the IL-6 regulation of muscle protein turnover during the initiation and progression of cachexia in the Apc(Min/+ mouse is not known. Cachexia progression was studied in Apc(Min/+ mice that were either weight stable (WS or had initial (≤5%, intermediate (6-19%, or extreme (≥20% body weight loss. The initiation of cachexia reduced %MPS 19% and a further ∼50% with additional weight loss. Muscle IGF-1 mRNA expression and mTOR targets were suppressed with the progression of body weight loss, while muscle AMPK phosphorylation (Thr 172, AMPK activity, and raptor phosphorylation (Ser 792 were not increased with the initiation of weight loss, but were induced as cachexia progressed. ATP dependent protein degradation increased during the initiation and progression of cachexia. However, ATP independent protein degradation was not increased until cachexia had progressed beyond the initial phase. IL-6 receptor antibody administration prevented body weight loss and suppressed muscle protein degradation, without any effect on muscle %MPS or IGF-1 associated signaling. In summary, the %MPS reduction during the initiation of cachexia is associated with IGF-1/mTOR signaling repression, while muscle AMPK activation and activation of ATP independent protein degradation occur later in the progression of cachexia. IL-6 receptor antibody treatment blocked cachexia progression through the suppression of muscle protein degradation, while not rescuing the suppression of muscle protein synthesis. Attenuation of IL-6 signaling was effective in blocking the progression of cachexia, but not sufficient to reverse the process.

  6. Detecting Nanophase Weathering Products with CheMin: Reference Intensity Ratios of Allophane, Aluminosilicate Gel, and Ferrihydrite

    Science.gov (United States)

    Rampe, E. B.; Bish, D. L.; Chipera, S. J.; Morris, R. V.; Achilles, C. N.; Ming, D W.; Blake, D. F.; Anderson, R. C.; Bristow, T. F.; Crisp, A.; DesMarais, D. J.; Downs, R. T.; Farmer, J. D.; Morookian, J. M.; Morrison, S. M.; Sarrazin, P.; Spanovich, N.; Stolper, E. M.; Treiman, A. H.; Vaniman, D. T.; Yen, A. S.

    2013-01-01

    X-ray diffraction (XRD) data collected of the Rocknest samples by the CheMin instrument on Mars Science Laboratory suggest the presence of poorly crystalline or amorphous materials [1], such as nanophase weathering products or volcanic and impact glasses. The identification of the type(s) of X-ray amorphous material at Rocknest is important because it can elucidate past aqueous weathering processes. The presence of volcanic and impact glasses would indicate that little chemical weathering has occurred because glass is highly susceptible to aqueous alteration. The presence of nanophase weathering products, such as allophane, nanophase iron-oxides, and/or palagonite, would indicate incipient chemical weathering. Furthermore, the types of weathering products present could help constrain pH conditions and identify which primary phases altered to form the weathering products. Quantitative analysis of phases from CheMin data is achieved through Reference Intensity Ratios (RIRs) and Rietveld refinement. The RIR of a mineral (or mineraloid) that relates the scattering power of that mineral (typically the most intense diffraction line) to the scattering power of a separate mineral standard such as corundum [2]. RIRs can be calculated from XRD patterns measured in the laboratory by mixing a mineral with a standard in known abundances and comparing diffraction line intensities of the mineral to the standard. X-ray amorphous phases (e.g., nanophase weathering products) have broad scattering signatures rather than sharp diffraction lines. Thus, RIRs of X-ray amorphous materials are calculated by comparing the area under one of these broad scattering signals with the area under a diffraction line in the standard. Here, we measured XRD patterns of nanophase weathering products (allophane, aluminosilicate gel, and ferrihydrite) mixed with a mineral standard (beryl) in the CheMinIV laboratory instrument and calculated their RIRs to help constrain the abundances of these phases in

  7. Assessment of aortitis by semiquantitative analysis of 180-min {sup 18}F-FDG PET/CT acquisition images

    Energy Technology Data Exchange (ETDEWEB)

    Martinez-Rodriguez, Isabel [University of Cantabria, Department of Nuclear Medicine, Marques de Valdecilla University Hospital, Santander (Spain); Hospital Universitario Marques de Valdecilla, S. Medicina Nuclear, Santander (Spain); Martinez-Amador, N.; Banzo, I.; Quirce, R.; Jimenez-Bonilla, J.; Arcocha-Torres, M. de; Ibanez-Bravo, S.; Lavado-Perez, C.; Bravo-Ferrer, Z.; Carril, J.M. [University of Cantabria, Department of Nuclear Medicine, Marques de Valdecilla University Hospital, Santander (Spain); Blanco, R.; Gonzalez-Gay, M.A. [University of Cantabria, Department of Rheumatology, Marques de Valdecilla University Hospital, Santander (Spain)

    2014-12-15

    The aim of this study was to evaluate the contribution of semiquantitative analysis of 180-min {sup 18}F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/CT images for the assessment of aortitis in cases of suspected large vessel vasculitis (LVV) and to establish a threshold index for application in the clinical setting. This prospective study included 43 patients (mean age 67.5 ± 12.9 years) with suspicion of LVV (25 with a final diagnosis of aortitis). {sup 18}F-FDG PET/CT scan was acquired 180 min after injection of 7 MBq/kg of {sup 18}F-FDG. A semiquantitative analysis was performed calculating the aortic wall maximum standardized uptake value (SUV{sub max}) (T), the lumen SUV{sub max} (B) and the target to background ratio (TBR). These results were also compared with those obtained in a control population. The mean aortic wall SUV{sub max} was 2.00 ± 0.62 for patients with aortitis and 1.45 ± 0.31 for patients without aortitis (p < 0.0001). The TBR was 1.66 ± 0.26 for patients with aortitis and 1.24 ± 0.08 for patients without aortitis (p < 0.0001). The differences were also statistically significant when the patients with aortitis and controls were compared. Receiver-operating characteristic (ROC) analysis revealed that the area under the curve was greater for the TBR than for the aortic wall SUV{sub max} (0.997 vs 0.871). The highest sensitivity and specificity was obtained for a TBR of 1.34 (sensitivity 100 %, specificity 94.4 %). Semiquantitative analysis of PET/CT images acquired 180 min after {sup 18}F-FDG injection and the TBR index of 1.34 show very high accuracy and, therefore, are strongly recommended for the diagnosis of aortitis in the clinical setting. (orig.)

  8. Role of Bone Marrow-Derived Stem Cells in Polyps Development in Mice with ApcMin/+ Mutation

    Directory of Open Access Journals (Sweden)

    Michele Barone

    2015-01-01

    Full Text Available We explored the hypothesis that an altered microenvironment (intestinal adenomatous polyp could modify the differentiation program of bone marrow-derived stem cells (BMSCs, involving them in colon carcinogenesis. Sublethally irradiated 8-week-old female ApcMin/+ mice were transplanted with bone marrow (BM cells obtained from either male age-matched ApcMin/+ (Apc-Tx-Apc or wild type (WT (WT-Tx-Apc mice. At 4 and 7 weeks after transplantation, BM-derived colonocytes were recognized by colocalization of Y-chromosome and Cdx2 protein (specific colonocyte marker. Polyp number, volume, and grade of dysplasia were not influenced by irradiation/transplantation procedures since they were similar in both untreated female ApcMin/+ and Apc-Tx-Apc mice. At 4 and 7 weeks after transplantation, a progressive significant reduction of polyp number and volume was observed in WT-Tx-Apc mice. Moreover, the number of WT-Tx-Apc mice with a high-grade dysplastic polyps significantly decreased as compared to Apc-Tx-Apc mice. Finally, at 4 and 7 weeks after transplantation, WT-Tx-Apc mice showed a progressive significant increase of Y+/Cdx2+ cells in “normal” mucosa, whereas, in the adenomatous tissue, Y+/Cdx2+ cells remained substantially unvaried. Our findings demonstrate that WT BMSCs do not participate in polyp development but rather inhibit their growth. The substitution of genotypically altered colonocytes with Y+/Cdx2+ cells probably contributes to this process.

  9. Channeling 5-min photospheric oscillations into the solar outer atmosphere through small-scale vertical magnetic flux tubes

    CERN Document Server

    Khomenko, E; Collados, M; Bueno, J Trujillo

    2008-01-01

    We report two-dimensional MHD simulations which demonstrate that photospheric 5-min oscillations can leak into the chromosphere inside small-scale vertical magnetic flux tubes. The results of our numerical experiments are compatible with those inferred from simultaneous spectropolarimetric observations of the photosphere and chromosphere obtained with the Tenerife Infrared Polarimeter (TIP) at 10830 A. We conclude that the efficiency of energy exchange by radiation in the solar photosphere can lead to a significant reduction of the cut-off frequency and may allow for the propagation of the 5 minutes waves vertically into the chromosphere.

  10. Introduction of MKZP (Min Ku Zirconium Process) as an alternative to pyroprocessing for used nuclear fuel management

    International Nuclear Information System (INIS)

    A new process to co-recover uranium and transuranic nuclides from used nuclear fuels was introduced, which was named 'MKZP' (Min Ku Zirconium Process), as an alternative of widely known pyroprocessing. Instead of an electrochemical reduction of the pyroprocessing, the MKZP employs Zr and ZrCl4 as reactants to chemically convert U3O8 into UCl3, which leads to a significant advantage in total number of processes. An addition of fresh zirconium can be minimized by employing cladding hull waste as a source of zirconium tetrachloride through a chlorination process. (author)

  11. The effects of initial conditions and control time on optimal actuator placement via a max-min Genetic Algorithm

    Energy Technology Data Exchange (ETDEWEB)

    Redmond, J. [Sandia National Labs., Albuquerque, NM (United States); Parker, G. [State Univ. of New York, Buffalo, NY (United States)

    1993-07-01

    This paper examines the role of the control objective and the control time in determining fuel-optimal actuator placement for structural vibration suppression. A general theory is developed that can be easily extended to include alternative performance metrics such as energy and time-optimal control. The performance metric defines a convex admissible control set which leads to a max-min optimization problem expressing optimal location as a function of initial conditions and control time. A solution procedure based on a nested Genetic Algorithm is presented and applied to an example problem. Results indicate that the optimal locations vary widely as a function of control time and initial conditions.

  12. Clinical Research into Ke Min Yin for Treatment of Persistent Allergic Rhinitis in Patients with Qi Deficiency and Blood Stasis

    Institute of Scientific and Technical Information of China (English)

    刘巧平; 刘建华; 刘大新

    2003-01-01

    @@ Persistent allergic rhinitis (PAR) is one of the common diseases at ear-nose-throat department. From August 1998 to May 2001, we randomly selected 60 cases of PAR with qi deficiency and blood stasis for a clinical observation. 30 patients in the treatment group were treated with Ke Min Yin (克敏饮), a herbal medicine, to supplement qi, expel wind, nourish blood and promote blood circulation; and the other 30 cases in the control group were treated with cetrine. Through systematic observation and statistical processing, the clinical research is summarized and reported in the following.

  13. EMAG2: A 2-arc min resolution Earth Magnetic Anomaly Grid compiled from satellite, airborne, and marine magnetic measurements

    Science.gov (United States)

    Maus, S.; Barckhausen, U.; Berkenbosch, H.; Bournas, N.; Brozena, J.; Childers, V.; Dostaler, F.; Fairhead, J.D.; Finn, C.; von Frese, R.R.B; Gaina, C.; Golynsky, S.; Kucks, R.; Lu, Hai; Milligan, P.; Mogren, S.; Muller, R.D.; Olesen, O.; Pilkington, M.; Saltus, R.; Schreckenberger, B.; Thebault, E.; Tontini, F.C.

    2009-01-01

    A global Earth Magnetic Anomaly Grid (EMAG2) has been compiled from satellite, ship, and airborne magnetic measurements. EMAG2 is a significant update of our previous candidate grid for the World Digital Magnetic Anomaly Map. The resolution has been improved from 3 arc min to 2 arc min, and the altitude has been reduced from 5 km to 4 km above the geoid. Additional grid and track line data have been included, both over land and the oceans. Wherever available, the original shipborne and airborne data were used instead of precompiled oceanic magnetic grids. Interpolation between sparse track lines in the oceans was improved by directional gridding and extrapolation, based on an oceanic crustal age model. The longest wavelengths (>330 km) were replaced with the latest CHAMP satellite magnetic field model MF6. EMAG2 is available at http://geomag.org/models/EMAG2 and for permanent archive at http://earthref.org/ cgi-bin/er.cgi?s=erda.cgi?n=970. ?? 2009 by the American Geophysical Union.

  14. Analyzing Sub-Threshold Bitcell Topologies and the Effects of Assist Methods on SRAM VMIN

    Directory of Open Access Journals (Sweden)

    James Boley

    2012-04-01

    Full Text Available The need for ultra low power circuits has forced circuit designers to scale voltage supplies into the sub-threshold region where energy per operation is minimized [1]. The problem with this is that the traditional 6T SRAM bitcell, used for data storage, becomes unreliable at voltages below about 700 mV due to process variations and decreased device drive strength [2]. In order to achieve reliable operation, new bitcell topologies and assist methods have been proposed. This paper provides a comparison of four different bitcell topologies using read and write VMIN as the metrics for evaluation. In addition, read and write assist methods were tested using the periphery voltage scaling techniques discussed in [4–13]. Measurements taken from a 180 nm test chip show read functionality (without assist methods down to 500 mV and write functionality down to 600 mV. Using assist methods can reduce both read and write VMIN by 100 mV over the unassisted test case.

  15. Miniature X-Ray Solar Spectrometer (MinXSS) - A Science-Oriented, University 3U CubeSat

    CERN Document Server

    Mason, James P; Caspi, Amir; Chamberlin, Phillip C; Moore, Christopher; Jones, Andrew; Kohnert, Rick; Li, Xinlin; Palo, Scott; Solomon, Stanley

    2015-01-01

    The Miniature X-ray Solar Spectrometer (MinXSS) is a 3-Unit (3U) CubeSat developed at the Laboratory for Atmospheric and Space Physics (LASP) at the University of Colorado, Boulder (CU). Over 40 students contributed to the project with professional mentorship and technical contributions from professors in the Aerospace Engineering Sciences Department at CU and from LASP scientists and engineers. The scientific objective of MinXSS is to study processes in the dynamic Sun, from quiet-Sun to solar flares, and to further understand how these changes in the Sun influence the Earth's atmosphere by providing unique spectral measurements of solar soft x-rays (SXRs). The enabling technology providing the advanced solar SXR spectral measurements is the Amptek X123, a commercial-off-the-shelf (COTS) silicon drift detector (SDD). The Amptek X123 has a low mass (~324 g after modification), modest power consumption (~2.5 W), and small volume (2.7" x 3.9" x 1.0"), making it ideal for a CubeSat. This paper provides an overvi...

  16. L'analyse in-situ par fluorescence X : une méthode adaptée à l'estimation de minéralisations en place : application aux minéralisations zincifères

    OpenAIRE

    Eteradossi, Olivier

    1985-01-01

    La possibilité d'utiliser un spectromètre XRF portable pour décrire et estimer une minéralisation avant abattage est étudiée en laboratoire puis sur des ces pratiques de prospection et d'exploitation. La détermination de le géométrie et l'estimation de la teneur d'un volume en place sont des processus indispensables à la bonne marche d'une exploitation minière. Ces informatlons, qui permettent de mieux gérer l'exploitation, soIt en engageant peu de frais de productIon pour des volumes non ren...

  17. Quasi-Min-Max Robust Model Predictive Control of Linear Parameter Varying Time-delay Systems%LPV时滞系统的准Min-Max鲁棒模型预测控制

    Institute of Scientific and Technical Information of China (English)

    邵晓巍; 张军; 王彪; 张新

    2006-01-01

    对于输入有约束的LPV时滞系统,提出了准Min-Max鲁棒模型预测控制.将无限时域"最坏情况"的目标函数分解为当前性能指标和终端代价项,给出了新的鲁棒性能指标上界和系统稳定的充分条件,通过求解LMI的凸优化获得状态反馈控制律,而LMI的可行性保证了闭环系统的稳定性.最后通过truck-trailer系统仿真验证了所提方法的有效性.

  18. A Decoding Algorithm Based on Layered Decoding and Min-max for Nonbinary LDPC Codes%一种基于分层译码和Min-max的多进制LDPC码译码算法

    Institute of Scientific and Technical Information of China (English)

    2013-01-01

      该文在现有译码算法的基础上提出一种高效的非二进制低密度奇偶校验码(NB-LDPC)译码方法,充分利用了分层译码算法与 Min-max 算法的优点,不但译码复杂度低、需要的存储空间小,而且可将译码速度提高一倍。应用该算法,对一种定义在GF(25)上的(620,509)码进行了仿真。该码的仿真结果表明:在相同误码率下,该文译码算法所需最大迭代次数仅为Zhang的算法(2011)的45%。%Based on decoding algorithms available nowadays, a high efficiency decoding algorithm for nonbinary low-density parity-check codes is proposed. The algorithm takes advantage of both the layered decoding algorithm and the Min-max algorithm, which not only achieves the low complexity and the low memory requirement, but also speeds up the decoding by two times. Simulations for a (620,509) code over GF(25) show that with the same bit error rate, the maximum iteration times of the proposed algorithm required is just 45%of Zhang’s algorithm presented in 2011.

  19. Reduction of intestinal polyp formation in min mice fed a high-fat diet with aloe vera gel extract.

    Science.gov (United States)

    Chihara, Takeshi; Shimpo, Kan; Beppu, Hidehiko; Tomatsu, Akiko; Kaneko, Takaaki; Tanaka, Miyuki; Yamada, Muneo; Abe, Fumiaki; Sonoda, Shigeru

    2013-01-01

    Aloe vera gel supercritical CO2 extract (AVGE) has been shown to contain five phytosterols, reduce visceral fat accumulation, and influence the metabolism of glucose and lipids in animal model experiments. Recent epidemiologic studies have shown that obesity is an established risk factor for several cancers including colorectal cancer. Therefore, we examined the effects of AVGE on intestinal polyp formation in Apc-deficient Min mice fed a high-fat diet. Male Min mice were divided into normal diet (ND), high fat diet (HFD), low dose AVGE (HFD+LAVGE) and high dose AVGE (HFD+HAVGE) groups. The ND group received AIN-93G diet and the latter 3 groups were given modified high-fat AIN-93G diet (HFD) for 7 weeks. AVGE was suspended in 0.5% carboxymethyl cellulose (CMC) and administered orally to mice in HFD+LAVGE and HFD+HAVGE groups every day (except on Sunday) for 7 weeks at a dose of 3.75 and 12.5 mg/kg body weight, respectively. ND and HFD groups received 0.5% CMC alone. Between weeks 4 and 7, body weights in the HFD and HFD+LAVGE groups were reduced more than those in the ND group. However, body weights were not reduced in the HFD+HAVGE group. Mice were sacrificed at the end of the experiment and their intestines were scored for polyps. No significant differences were observed in either the incidence and multiplicity of intestinal polyps (≥0.5 mm in a diameter) among the three groups fed HFD. However, when intestinal polyps were categorized by their size into 0.5-1.4, 1.5-2.4, or ≥2.5 mm, the incidence and multiplicity of large polyps (≥2.5 mm) in the intestine in the HFD+HAVGE group were significantly lower than those in the HFD group. We measured plasma lipid (triglycerides and total cholesterol) and adipocytokine [interleukin-6 and high molecular weight (HMW) adiponectin] levels as possible indicators of mechanisms of inhibition. The results showed that HMW adiponectin levels in the HFD group were significantly lower than those in the ND group. However, the

  20. Approche métallogénique du "Greenstone Belt" de Bogoin (RCA). Sa minéralisation en or

    OpenAIRE

    Biandja, Jean

    1988-01-01

    La minéralisation aurifère primaire du secteur de Bogoin se présente sous forme d'un stockwerk quartzeux de direction N-S encaissé dans des roches vertes. Ces dernières appartiennent à une série métamorphique (limite faciès schistes verts-amphibolite) plissée en un synclinorium de direction N-S qui dessine un "doigt de gant" dans un vaste massif granito-gneissique. La foliation principale (SP) est plan axial de cette structure. L'ensemble est réputé archéen. Le synclinal s'ennoie vers le Sud ...

  1. On the origin of the conductance asymmetry in CeMIn5 (M=Co, Rh, Ir)

    International Nuclear Information System (INIS)

    Asymmetric differential conductance has been frequently observed in heavy fermion point-contact junctions. We report such data obtained from the Ce-based 1-1-5 compounds CeMIn5 (M=Co, Rh, Ir). Apart from characteristics due to superconductivity or antiferromagnetism, a striking common feature is an asymmetry in the background conductance, which shows nontrivial temperature and voltage dependencies. These behaviors cannot be explained by the local heating model combined with large Seebeck effect in heavy fermions. We propose that a Fano-like interference may cause the asymmetry. The interference can occur between two conductance channels, one into the conduction band and the other into the heavy electron band formed by the hybridization of conduction electrons with localized f-electrons.

  2. Professor QIN Min's Acupuncture Holistic Therapies System%秦敏针灸整体疗法体系初探

    Institute of Scientific and Technical Information of China (English)

    曾科学; 李敏; 文希; 姚国新; 孙维正; 史琳琳

    2013-01-01

    整体观念是中医理论体系的主要特点之一,针灸疗法的核心也是整体观念.秦敏教授系全国第四批名老中医学术经验继承人,在临床实践中总结出针灸整体疗法,文章从理、法、方、术等四个方面对秦敏教授针灸整体疗法理论体系进行了初探和总结.在整体观念的指导下,确定安神醒脑头皮针、调气扶阳腹针、太阳夹督围刺法三大特色针灸方法,以秦氏飞针术调和阴阳,贯通任督,整体调节,达到治疗的目的.%The holism is one of the main characteristics of the theoretical system of traditional Chinese medicine,the core concept of acupuncture therapy is holism.Professor QIN Min is the fourth batch of national academic experience of famous Chinese medicine heir,in clinical practice of acupuncture therapy and has summed up the acupuncture holism.This article is to discuss and summary acupuncture holistic theory of Professor QIN Min from four aspects including theory,rule,method,technology.In the overall concept,three characteristics acupuncture,that is Anshenxingnao scalp needle,Tiaoqifuyang abdominal acupuncture,Taiyangjiadu surrounded needling method,are determined.Qinshifeizhenshu can be used to balance Yin and Yang,through Ren and Du meridians,regulating the whole condition,and achieving the purpose of treatment.

  3. Plant stanols induce intestinal tumor formation by up-regulating Wnt and EGFR signaling in Apc Min mice.

    Science.gov (United States)

    Marttinen, Maija; Päivärinta, Essi; Storvik, Markus; Huikko, Laura; Luoma-Halkola, Heli; Piironen, Vieno; Pajari, Anne-Maria; Mutanen, Marja

    2013-01-01

    The rate of APC mutations in the intestine increases in middle-age. At the same period of life, plant sterol and stanol enriched functional foods are introduced to diet to lower blood cholesterol. This study examined the effect of plant stanol enriched diet on intestinal adenoma formation in the Apc(Min) mouse. Apc(Min) mice were fed 0.8% plant stanol diet or control diet for nine weeks. Cholesterol, plant sterols and plant stanols were analyzed from the caecum content and the intestinal mucosa. Levels of β-catenin, cyclin D1, epidermal growth factor receptor (EGFR) and extracellular signal-regulated kinase 1/2 (ERK1/2) were measured from the intestinal mucosa by Western blotting. Gene expression was determined from the intestinal mucosa using Affymetrix and the data were analyzed for enriched categories and pathways. Plant stanols induced adenoma formation in the small intestine, however, the adenoma size was not affected. We saw increased levels of nuclear β-catenin, phosphorylated β-catenin (Ser675 and Ser552), nuclear cyclin D1, total and phosphorylated EGFR and phosphorylated ERK1/2 in the intestinal mucosa after plant stanol feeding. The Affymetrix data demonstrate that several enzymes of cholesterol synthesis pathway were up-regulated, although the cholesterol level in the intestinal mucosa was not altered. We show that plant stanols induce adenoma formation by activating Wnt and EGFR signaling. EGFR signaling seems to have promoted β-catenin phosphorylation and its translocation into the nucleus, where the expression of cyclin D1 was increased. Up-regulated cholesterol synthesis may partly explain the increased EGFR signaling in the plant stanol-fed mice.

  4. IL-6 regulation on skeletal muscle mitochondrial remodeling during cancer cachexia in the ApcMin/+ mouse

    Directory of Open Access Journals (Sweden)

    White James P

    2012-07-01

    Full Text Available Abstract Background Muscle protein turnover regulation during cancer cachexia is being rapidly defined, and skeletal muscle mitochondria function appears coupled to processes regulating muscle wasting. Skeletal muscle oxidative capacity and the expression of proteins regulating mitochondrial biogenesis and dynamics are disrupted in severely cachectic ApcMin/+ mice. It has not been determined if these changes occur at the onset of cachexia and are necessary for the progression of muscle wasting. Exercise and anti-cytokine therapies have proven effective in preventing cachexia development in tumor bearing mice, while their effect on mitochondrial content, biogenesis and dynamics is not well understood. The purposes of this study were to 1 determine IL-6 regulation on mitochondrial remodeling/dysfunction during the progression of cancer cachexia and 2 to determine if exercise training can attenuate mitochondrial dysfunction and the induction of proteolytic pathways during IL-6 induced cancer cachexia. Methods ApcMin/+ mice were examined during the progression of cachexia, after systemic interleukin (IL-6r antibody treatment, or after IL-6 over-expression with or without exercise. Direct effects of IL-6 on mitochondrial remodeling were examined in cultured C2C12 myoblasts. Results Mitochondrial content was not reduced during the initial development of cachexia, while muscle PGC-1α and fusion (Mfn1, Mfn2 protein expression was repressed. With progressive weight loss mitochondrial content decreased, PGC-1α and fusion proteins were further suppressed, and fission protein (FIS1 was induced. IL-6 receptor antibody administration after the onset of cachexia improved mitochondrial content, PGC-1α, Mfn1/Mfn2 and FIS1 protein expression. IL-6 over-expression in pre-cachectic mice accelerated body weight loss and muscle wasting, without reducing mitochondrial content, while PGC-1α and Mfn1/Mfn2 protein expression was suppressed and FIS1 protein expression

  5. Lichens as possible agents of sandstone deterioration in Jesuitic ruins of San Ignacio Miní (Misiones Province, Argentina

    Directory of Open Access Journals (Sweden)

    Rosato, V. G.

    2010-09-01

    Full Text Available The ruins of San Ignacio Miní, in NE Argentina, Misiones Province, included by the UNESCO in the list of World Heritage in 1984, were built in the 18th century by the Guarani people under the supervision of the Jesuite Congregation. The ruins are located in a tropical weather zone, exposed to extreme conditions of heat and humidity affecting the rocks used in its construction. These rocks are identified as siliceous sandstones, mainly formed by rounded to subrounded clasts, with scarce angulose particles, containing 96% quartz. Weather characteristics encourage the growth of vascular plants as well as algae and mosses and other organisms that damage materials. Among these, there are 18 lichen species (belonging to 18 genera, 8 foliose, 3 fruticose and 7 crustose. The damaging action of these lichens has been observed through SEM observations and EDAX microanalysis of rock samples colonized by Caloplaca sp. and Buellia sp.

    Incluidas en la lista de Patrimonio Mundial por la UNESCO, las ruinas de San Ignacio Miní, en el NE de Argentina, provincia de Misiones, fueron construidas en el siglo XVIII por pobladores guaraníes supervisados por la Compañía de Jesús. Las ruinas se encuentran en una zona de clima tropical, expuestas a condiciones extremas de calor y humedad que alteran a las rocas empleadas en su construcción. Estas rocas se identifican como areniscas silíceas, formadas por clastos redondeados a sub-redondeados, con escasas partículas angulosas, con un contenido de 96,0% cuarzo. Las características del clima favorecen el desarrollo tanto de plantas vasculares como también de musgos, algas y otros organismos capaces de dañar a los materiales. Entre éstos se incluyen 18 especies de líquenes (pertenecientes a 18 géneros, 8 foliosos, 3 fruticosos y 7 crustosos. Las observaciones con SEM y los microanálisis EDE de muestras de roca colonizadas por Caloplaca sp. y Buellia sp sugieren que estos líquenes ejercen una acci

  6. Effects of gender on stroke rates, critical speed and velocity of a 30-min swim in young swimmers.

    Science.gov (United States)

    Greco, Camila C; Pelarigo, Jailton G; Figueira, Tiago R; Denadai, Benedito S

    2007-01-01

    Our objective was to analyze the effect of gender on the relationship between stroke rates corresponding to critical speed (SRCS) and maximal speed of 30 min (SRS30) in young swimmers. Twenty two males (GM1) (Age = 15.4 ± 2.1 yr., Body mass = 63.7 ± 12.9 kg, Stature = 1.73 ± 0.09 m) and fourteen female (GF) swimmers (Age = 15.1 ± 1.6 yr., Body mass = 58.3 ± 8.8 kg, Stature = 1.65 ± 0.06 m) were studied. A subset of males (GM2) was matched to the GF by their velocity for a 30 min swim (S30). The critical speed (CS) was determined through the slope of the linear regression line between the distances (200 and 400 m) and participant's respective times. CS was significantly higher than S30 in males (GM1 - 1.25 and 1.16 and GM2 - 1.21 and 1.12 m·s(-1)) and females (GF - 1.15 and 1.11 m·s(-1)). There was no significant difference between SRCS and SRS30 in males (GM1 - 34.16 and 32.32 and GM2 - 34.67 and 32.46 cycle·s(-1), respectively) and females (GF - 34.18 and 33.67 cycle·s(-1), respectively). There was a significant correlation between CS and S30 (GM1 - r = 0.89, GF - r = 0.94 and GM2 - r = 0.90) and between SRCS and SRS30 (GM1 - r = 0.89, GF - r = 0.80 and GM2 - r = 0.88). Thus, the relationship between SRCS and SRS30 is not influenced by gender, in swimmers with similar and different aerobic capacity levels. Key pointsThe main finding of this study was that the relationship between SRCS and SRS30, which is not dependent on gender, in swimmers with similar and different aerobic capacity levels.In swimmers who had different S30 values, CS was higher than S30 in boys and girls, and CS and S30 were higher in boys than girls, but SRCS and SRS30 were similar between genders.In swimmers who had similar S30 values, CS was higher than S30 in boys and girls. However, boys still presented higher values of CS than girls. SRCS was higher than SRS30 in boys, but these variables were similar in girls. SRCS and SRS30 were similar between genders.Girls presented lower

  7. Individual variability in cardiac biomarker release after 30 min of high-intensity rowing in elite and amateur athletes.

    Science.gov (United States)

    Legaz-Arrese, Alejandro; López-Laval, Isaac; George, Keith; Puente-Lanzarote, Juan José; Moliner-Urdiales, Diego; Ayala-Tajuelo, Vicente Javier; Mayolas-Pi, Carmen; Reverter-Masià, Joaquín

    2015-09-01

    This study had two objectives: (i) to examine individual variation in the pattern of cardiac troponin I (cTnI) and N-terminal pro-brain natriuretic peptide (NT-proBNP) release in response to high-intensity rowing exercise, and (ii) to establish whether individual heterogeneity in biomarker appearance was influenced by athletic status (elite vs. amateur). We examined cTnI and NT-proBNP in 18 elite and 14 amateur rowers before and 5 min, 1, 3, 6, 12, and 24 h after a 30-min maximal rowing test. Compared with pre-exercise levels, peak postexercise cTnI (pre: 0.014 ± 0.030 μg·L(-1); peak post: 0.058 ± 0.091 μg·L(-1); p = 0.000) and NT-proBNP (pre: 15 ± 11 ng·L(-1); peak post: 31 ± 19 ng·L(-1); p = 0.000) were elevated. Substantial individual heterogeneity in peak and time-course data was noted for cTnI. Peak cTnI exceeded the upper reference limit (URL) in 9 elite and 3 amateur rowers. No rower exceeded the URL for NT-proBNP. Elite rowers had higher baseline (0.019 ± 0.038 vs. 0.008 ± 0.015 μg·L(-1); p = 0.003) and peak postexercise cTnI (0.080 ± 0.115 vs. 0.030 ± 0.029 μg·L(-1); p = 0.022) than amateur rowers, but the change with exercise was similar between groups. There were no significant differences in baseline and peak postexercise NT-proBNP between groups. In summary, marked individuality in the cTnI response to a short but high-intensity rowing bout was observed. Athletic status did not seem to affect the change in cardiac biomarkers in response to high-intensity exercise. PMID:26307519

  8. Three 15-min bouts of moderate postmeal walking significantly improves 24-h glycemic control in older people at risk for impaired glucose tolerance

    Science.gov (United States)

    The purpose of this study was to compare the effectiveness of three 15-min bouts of postmeal walking with 45 min of sustained walking on 24-h glycemic control in older persons at risk for glucose intolerance. Inactive older (=60 years of age) participants (N = 10) were recruited from the community a...

  9. Real-time imaging of myeloid cells dynamics in ApcMin/+ intestinal tumors by spinning disk confocal microscopy.

    Science.gov (United States)

    Bonnans, Caroline; Lohela, Marja; Werb, Zena

    2014-10-06

    Myeloid cells are the most abundant immune cells within tumors and have been shown to promote tumor progression. Modern intravital imaging techniques enable the observation of live cellular behavior inside the organ but can be challenging in some types of cancer due to organ and tumor accessibility such as intestine. Direct observation of intestinal tumors has not been previously reported. A surgical procedure described here allows direct observation of myeloid cell dynamics within the intestinal tumors in live mice by using transgenic fluorescent reporter mice and injectable tracers or antibodies. For this purpose, a four-color, multi-region, micro-lensed spinning disk confocal microscope that allows long-term continuous imaging with rapid image acquisition has been used. Apc(Min/+) mice that develop multiple adenomas in the small intestine are crossed with c-fms-EGFP mice to visualize myeloid cells and with ACTB-ECFP mice to visualize intestinal epithelial cells of the crypts. Procedures for labeling different tumor components, such as blood vessels and neutrophils, and the procedure for positioning the tumor for imaging through the serosal surface are also described. Time-lapse movies compiled from several hours of imaging allow the analysis of myeloid cell behavior in situ in the intestinal microenvironment.

  10. Integrated water vapor from IGS ground-based GPS observations. Initial results from a global 5-min data set

    Energy Technology Data Exchange (ETDEWEB)

    Heise, S.; Dick, G.; Gendt, G.; Schmidt, T.; Wickert, J. [GFZ German Research Centre for Geosciences, Potsdam (Germany). Dept. 1 Geodesy and Remote Sensing

    2009-07-01

    Ground based GPS zenith path delay (ZPD) measurements are well established as a powerful tool for integrated water vapor (IWV) observation. The International GNSS Service (IGS) provides ZPD data of currently more than 300 globally distributed GPS stations. To derive IWV from these data, meteorological information (ground pressure and mean temperature above the station) are needed. Only a limited number of IGS stations is equipped with meteorological ground sensors up to now. Thus, meteorological data for IWV conversion are usually derived from nearby ground meteorological observations (ground pressure) and meteorological analyses (mean temperature). In this paper we demonstrate for the first time the applicability of ground pressure data from ECMWF meteorological analysis fields in this context. Beside simplified data handling (no single station data and quality control) this approach allows for IWV derivation if nearby meteorological stations are not available. Using ECMWF ground pressure and mean temperature data the new IGS 5-min ZPD data set has been converted to IWV for the first time. We present initial results from selected stations with ground meteorological sensors including pressure and temperature comparisons between ECMWF and local measurements. The GPS IWV is generally validated by comparison with ECMWF IWV. The ECMWF derived station meteorological data are compared with local measurements at all accordingly equipped stations. Based on this comparison, the mean error (in terms of standard deviation) introduced by time interpolation of the 6-hourly ECMWF data is estimated below 0.2 mm IWV. (orig.)

  11. A Count Model to Study the Correlates of 60 Min of Daily Physical Activity in Portuguese Children

    Directory of Open Access Journals (Sweden)

    Alessandra Borges

    2015-02-01

    Full Text Available This study aimed to present data on Portuguese children (aged 9–11 years complying with moderate-to-vigorous physical activity (MVPA guidelines, and to identify the importance of correlates from multiple domains associated with meeting the guidelines. Physical activity (PA was objectively assessed by accelerometry throughout seven days on 777 children. A count model using Poisson regression was used to identify the best set of correlates that predicts the variability in meeting the guidelines. Only 3.1% of children met the recommended daily 60 min of MVPA for all seven days of the week. Further, the Cochrane–Armitage chi-square test indicated a linear and negative trend (p < 0.001 from none to all seven days of children complying with the guidelines. The count model explained 22% of the variance in meeting MVPA guidelines daily. Being a girl, having a higher BMI, belonging to families with higher income, sleeping more and taking greater time walking from home to a sporting venue significantly reduced the probability of meeting daily recommended MVPA across the seven days. Furthermore, compared to girls, increasing sleep time in boys increased their chances of compliance with the MVPA recommendations. These results reinforce the relevance of considering different covariates’ roles on PA compliance when designing efficient intervention strategies to promote healthy and active lifestyles in children.

  12. An Adaptive Fuzzy Min-Max Neural Network Classifier Based on Principle Component Analysis and Adaptive Genetic Algorithm

    Directory of Open Access Journals (Sweden)

    Jinhai Liu

    2012-01-01

    Full Text Available A novel adaptive fuzzy min-max neural network classifier called AFMN is proposed in this paper. Combined with principle component analysis and adaptive genetic algorithm, this integrated system can serve as a supervised and real-time classification technique. Considering the loophole in the expansion-contraction process of FMNN and GFMN and the overcomplex network architecture of FMCN, AFMN maintains the simple architecture of FMNN for fast learning and testing while rewriting the membership function, the expansion and contraction rules for hyperbox generation to solve the confusion problems in the hyperbox overlap region. Meanwhile, principle component analysis is adopted to finish dataset dimensionality reduction for increasing learning efficiency. After training, the confidence coefficient of each hyperbox is calculated based on the distribution of samples. During classifying procedure, utilizing adaptive genetic algorithm to complete parameter optimization for AFMN can also fasten the entire procedure than traversal method. For conditions where training samples are insufficient, data core weight updating is indispensible to enhance the robustness of classifier and the modified membership function can adjust itself according to the input varieties. The paper demonstrates the performance of AFMN through substantial examples in terms of classification accuracy and operating speed by comparing it with FMNN, GFMN, and FMCN.

  13. Random Secure Comparator Selection Based Privacy-Preserving MAX/MIN Query Processing in Two-Tiered Sensor Networks

    Directory of Open Access Journals (Sweden)

    Hua Dai

    2016-01-01

    Full Text Available Privacy-preserving data queries for wireless sensor networks (WSNs have drawn much attention recently. This paper proposes a privacy-preserving MAX/MIN query processing approach based on random secure comparator selection in two-tiered sensor network, which is denoted by RSCS-PMQ. The secret comparison model is built on the basis of the secure comparator which is defined by 0-1 encoding and HMAC. And the minimal set of highest secure comparators generating algorithm MaxRSC is proposed, which is the key to realize RSCS-PMQ. In the data collection procedures, the sensor node randomly selects a generated secure comparator of the maximum data into ciphertext which is submitted to the nearby master node. In the query processing procedures, the master node utilizes the MaxRSC algorithm to determine the corresponding minimal set of candidate ciphertexts containing the query results and returns it to the base station. And the base station obtains the plaintext query result through decryption. The theoretical analysis and experimental result indicate that RSCS-PMQ can preserve the privacy of sensor data and query result from master nodes even if they are compromised, and it has a better performance on the network communication cost than the existing approaches.

  14. Recent fully non-inductive operation results in Tore Supra with 6 min, 1 GJ plasma discharges

    International Nuclear Information System (INIS)

    The experimental programme of Tore Supra, the largest superconducting tokamak in the world (a = 0.72 m, R = 2.4 m, Ip T < 4.5 T) was devoted in 2003 to studying the heat removal capability and particle exhaust in steady-state fully non-inductive current drive discharges simultaneously. This required both advanced technology integration and steady-state real-time plasma control. In particular, an improvement of the plasma position to within a range of few millimetres, and new real-time controls of radio frequency power and various actuators built around a shared memory network, have allowed Tore Supra to access a powerful steady-state regime with an improved safety level for the actively cooled plasma facing components. Feedback controlled fully non-inductive plasma discharges have been sustained in a steady-state regime for up to 6 min with a new world record for injected-extracted energy exceeding 1 GJ. Experimental results and an analysis of the physics involved in these discharges are reported and discussed. (author)

  15. Real time control of fully non-inductive operation in Tore Supra leading to 6 min, 1 GJ plasma discharges

    International Nuclear Information System (INIS)

    The experimental programme of Tore Supra (a = 0.72 m, R = 2.4 m, I p T < 4.5 T) has been devoted in 2003 to study simultaneously heat removal capability and particle exhaust in steady-state fully non-inductive current drive discharges. This required both advanced technology integration and steady-state real time plasma control. In particular, an improvement of the plasma position within a few millimetres range, and new real time cross controls between radio frequency (RF) power and various actuators built around a shared memory network, have allowed Tore Supra to access a powerful steady-state regime with an improved safety level for the actively cooled plasma facing components. Feedback controlled fully non-inductive plasma discharges have been sustained in a steady-state regime up to 6 min with a new world record of injected-extracted energy exceeding 1 GJ. Advanced tools, experimental results and brief physics analysis of these discharges are presented and discussed

  16. A count model to study the correlates of 60 min of daily physical activity in Portuguese children.

    Science.gov (United States)

    Borges, Alessandra; Gomes, Thayse Natacha; Santos, Daniel; Pereira, Sara; dos Santos, Fernanda K; Chaves, Raquel; Katzmarzyk, Peter T; Maia, José

    2015-03-01

    This study aimed to present data on Portuguese children (aged 9-11 years) complying with moderate-to-vigorous physical activity (MVPA) guidelines, and to identify the importance of correlates from multiple domains associated with meeting the guidelines. Physical activity (PA) was objectively assessed by accelerometry throughout seven days on 777 children. A count model using Poisson regression was used to identify the best set of correlates that predicts the variability in meeting the guidelines. Only 3.1% of children met the recommended daily 60 min of MVPA for all seven days of the week. Further, the Cochrane-Armitage chi-square test indicated a linear and negative trend (psleeping more and taking greater time walking from home to a sporting venue significantly reduced the probability of meeting daily recommended MVPA across the seven days. Furthermore, compared to girls, increasing sleep time in boys increased their chances of compliance with the MVPA recommendations. These results reinforce the relevance of considering different covariates' roles on PA compliance when designing efficient intervention strategies to promote healthy and active lifestyles in children. PMID:25730296

  17. Early static {sup 18}F-FET-PET scans have a higher accuracy for glioma grading than the standard 20-40 min scans

    Energy Technology Data Exchange (ETDEWEB)

    Albert, Nathalie L.; Winkelmann, Isabel; Wenter, Vera; Mille, Erik; Todica, Andrei; Brendel, Matthias; Bartenstein, Peter [Ludwig-Maximilians-University Munich, Department of Nuclear Medicine, Munich (Germany); Suchorska, Bogdana; Tonn, Joerg-Christian [Ludwig-Maximilians-University Munich, Department of Neurosurgery, Munich (Germany); Schmid-Tannwald, Christine [Ludwig-Maximilians-University Munich, Institute for Clinical Radiology, Munich (Germany); La Fougere, Christian [University of Tuebingen, Division of Nuclear Medicine and Clinical Molecular Imaging, Department of Radiology, Tuebingen (Germany)

    2016-06-15

    Current guidelines for glioma imaging by positron emission tomography (PET) using the amino acid analogue O-(2-[{sup 18}F]fluoroethyl)-L-tyrosine ({sup 18}F-FET) recommend image acquisition from 20-40 min post injection (p.i.). The maximal tumour-to-background evaluation (TBR{sub max}) obtained in these summation images does not enable reliable differentiation between low and high grade glioma (LGG and HGG), which, however, can be achieved by dynamic {sup 18}F-FET-PET. We investigated the accuracy of tumour grading using TBR{sub max} values at different earlier time points after tracer injection. Three hundred and fourteen patients with histologically proven primary diagnosis of glioma (131 LGG, 183 HGG) who had undergone 40-min dynamic {sup 18}F-FET-PET scans were retrospectively evaluated. TBR{sub max} was assessed in the standard 20-40 min summation images, as well as in summation images from 0-10 min, 5-15 min, 5-20 min, and 15-30 min p.i., and kinetic analysis was performed. TBR{sub max} values and kinetic analysis were correlated with histological classification. ROC analyses were performed for each time frame and sensitivity, specificity, and accuracy were assessed. TBR{sub max} values in the earlier summation images were significantly better for tumour grading (P < 0.001) when compared to standard 20-40 min scans, with best results for the early 5-15 min scan. This was due to higher TBR{sub max} in the HGG (3.9 vs. 3.3; p < 0.001), while TBR{sub max} remained nearly stable in the LGG (2.2 vs. 2.1). Overall, accuracy increased from 70 % in the 20-40 min analysis to 77 % in the 5-15 min images, but did not reach the accuracy of dynamic analysis (80 %). Early TBR{sub max} assessment (5-15 min p.i.) is more accurate for the differentiation between LGG and HGG than the standard static scan (20-40 min p.i.) mainly caused by the characteristic high {sup 18}F-FET uptake of HGG in the initial phase. Therefore, when dynamic {sup 18}F-FET-PET cannot be performed

  18. MicroSISAK. Continuous liquid-liquid extractions of radionuclides at {>=} 0.2 mL/min

    Energy Technology Data Exchange (ETDEWEB)

    Hild, D.; Eberhardt, K.; Kratz, J.V.; Wiehl, N. [Mainz Univ. (Germany). Inst. fuer Kernchemie; Even, J. [Mainz Univ. (Germany). Inst. fuer Kernchemie; Helmholtz-Institut Mainz, Mainz (Germany); Loeb, P.; Werner, B.; Hofmann, C. [Institut fuer Mikrotechnik Mainz GmbH, Mainz (Germany)

    2013-07-01

    Continuous liquid-liquid extraction of short-lived radionuclides has traditionally been performed with the SISAK system consisting of static mixers and H-centrifuges for phase separation. SISAK operates at flow rates of typically 1 mL/s. Thus, it produces large volumes of radioactive liquid waste that is difficult to dispose of. Therefore, it has been aimed to develop and use a further miniaturised extraction unit based on microtechnology and precision engineering to reduce the flow rate by at least two orders of magnitude. The accordingly developed MicroSISAK device is a micro membrane extractor in which a micromixer element with 2 x 16 feed channels of 30 {mu}m width followed by a 60 {mu}m high mixing chamber is used for intimately contacting the aqueous and organic phase. Subsequent phase separation is achieved via hydrophobic Teflon membranes with a pore size of 1 {mu}m. The MicroSISAK device has been tested and optimized with radiotracers of the group-4 elements Zr and Hf in the system H{sub 2}SO{sub 4}/trioctyl amine (TOA) in toluene. At a temperature of 58 C and a flow rate of 0.2 mL/min of both phases, extraction yields of 87 {+-} 3% were achieved. The transport time from the micromixer to the first Teflon membrane was in this case 3.9s. It can be shortened to 1.56s at a flow rate of 0.5 mL/min. Under similar conditions, the extraction yield of {sup 99m}Tc milked from a {sup 99}Mo generator in the system HNO{sub 3}/tetraphenyl arsonium chloride (TPAC) in chloroform was 83 {+-} 3%. In an on-line experiment at the TRIGA Mainz reactor, short-lived Tc isotopes produced in the fission of {sup 235}U with thermal neutrons were transported by a He/KCl gas-jet to the chemistry apparatus, deposited by impaction, dissolved in 0.01 mol/L HNO{sub 3}/KBrO{sub 3}, and extracted into 10{sup -4} mol/L TPAC in chloroform in MicroSISAK. The separated phases were transported via capillaries to two separate flow-through cells positioned in front of two Ge detectors. The

  19. Study of the excited states of 187Pt in the decay of 187Au (8.4 min)

    International Nuclear Information System (INIS)

    The decay of 187Au to 187Pt has been studied with mass-separated sources from the UNISOR facility. Multiscaled spectra of γ-rays, x-rays, and conversion electrons were obtained along with γ-γ-t, γ-x-t, e--γ-t, and e--x-t coincidence data. The half life of 187Au was measured to be 8.4 +- 0.3 min. A decay scheme consisting of 56 excited states and 245 transitions that incorporates 88% of the decay intensity assigned to 187Au has been constructed. The i/sub 13/2/ band in 187Pt is populated through low-spin band members in approximately 4% of the decays of 187Au. Levels at 260, 288, and 507 keV are found to de-excite by EO transitions. The ground-state decay energy is deduced to be Q/sub EC/ = 3.90 +- 0.15 MeV from a γ-gated β+/EC ratio. The positive parity states in 187Pt are compared with calculations made with the Lund Model [Larsson et. al., 1978]. Also an anion exchange and distillation procedure is described for preparing reactor-produced carrier-free 18F as K18F complexed with 18-crown-6 in acetonitrile for subsequent synthesis of labelled organic compounds. The reaction sequence 6Li(n,t) 4He - 16O(t,n) 18F produced yields of approximately 250 mCi of 18F per hour per gram of 96% enriched 6Li, as 6LiOH x H2O target, in a reactor thermal-neutron flux of 3 x 1013 n cm-2sec-1. Yields of tritium-free carrier-free 18F dissolved in the crown ether solution typically reach 85 +- 5% within the 45 minutes required for the radiochemical procedure

  20. CH4MIN technology: a sustainable solution for the destruction of dilute methane emissions and the production of useful energy

    International Nuclear Information System (INIS)

    Large quantities of methane are released into the atmosphere by underground coal mines. The coal industry worldwide is responsible for the emission of the equivalent of 460 million tons per year of carbon dioxide. Of that amount, approximately 250 million tons per year originate from coal mine ventilation air. A novel technology providing a sustainable energy solution to the conversion of these emissions into useful energy has been developed by the Canada Energy Technology Centre in Varennes, part of Natural Resources Canada. The technology has been called CH4MIN and is capable of converting the dilute methane contained in the emissions and produces useful energy in the form of heat or electricity. The technology couples the catalytic oxidation of the lean emissions in the reactor with regenerative heat exchange. Two beds of inert material are separated by the catalytic bed, and it acts as the regenerative heat exchanger, providing a very efficient heat transfer. Thermal stability and stable reactor operation are ensured by a periodic reversal in the direction of the flow of the mine ventilation air. Some of the heat from the reactor is used to produce electricity or heat for the mine. The preparation of a mathematical simulation of the expected process and an independent techno-economic feasibility study were performed during phase I of the development. New chemical reactor concepts, complex heat and mass transfer simulations were developed during phase II, as well as the development of a new two-dimensional model and algorithms, a novel design of a flow reversal reactor, the construction of unique large scale 500 millimeter diameter pilot scale reactor, the selection and testing of a catalyst with low pressure drop, high temperature resistance, poison resistance, and low cost. The preparation of the first industrial demonstration is being carried out as part of phase III. This phase includes the licensing of the technology to private industry along with obtaining

  1. Chronic effects of palmitate overload on nutrient-induced insulin secretion and autocrine signalling in pancreatic MIN6 beta cells.

    Directory of Open Access Journals (Sweden)

    Maria L Watson

    Full Text Available BACKGROUND: Sustained exposure of pancreatic β cells to an increase in saturated fatty acids induces pleiotropic effects on β-cell function, including a reduction in stimulus-induced insulin secretion. The objective of this study was to investigate the effects of chronic over supply of palmitate upon glucose- and amino acid-stimulated insulin secretion (GSIS and AASIS, respectively and autocrine-dependent insulin signalling with particular focus on the importance of ceramide, ERK and CaMKII signalling. PRINCIPAL FINDINGS: GSIS and AASIS were both stimulated by >7-fold resulting in autocrine-dependent activation of protein kinase B (PKB, also known as Akt. Insulin release was dependent upon nutrient-induced activation of calcium/calmodulin-dependent protein kinase II (CaMKII and extracellular signal-regulated kinase (ERK as their pharmacological inhibition suppressed GSIS/AASIS significantly. Chronic (48 h, 0.4 mM palmitate treatment blunted glucose/AA-induced activation of CaMKII and ERK and caused a concomitant reduction (~75% in GSIS/AASIS and autocrine-dependent activation of PKB. This inhibition could not be attributed to enhanced mitochondrial fatty acid uptake/oxidation or ceramide synthesis, which were unaffected by palmitate. In contrast, diacylglycerol synthesis was elevated suggesting increased palmitate esterification rather than oxidation may contribute to impaired stimulus-secretion coupling. Consistent with this, 2-bromopalmitate, a non-oxidisable palmitate analogue, inhibited GSIS as effectively as palmitate. CONCLUSIONS: Our results exclude changes in ceramide content or mitochondrial fatty acid handling as factors initiating palmitate-induced defects in insulin release from MIN6 β cells, but suggest that reduced CaMKII and ERK activation associated with palmitate overload may contribute to impaired stimulus-induced insulin secretion.

  2. Cdk8 deletion in the Apc(Min) murine tumour model represses EZH2 activity and accelerates tumourigenesis.

    Science.gov (United States)

    McCleland, Mark L; Soukup, Tim M; Liu, Scot D; Esensten, Jonathan H; de Sousa e Melo, Felipe; Yaylaoglu, Murat; Warming, Soren; Roose-Girma, Merone; Firestein, Ron

    2015-12-01

    CDK8 is a dissociable kinase module of the Mediator complex and has been shown to play an important role in transcriptional regulation in organisms as diverse as yeast and humans. Recent studies suggest that CDK8 functions as an oncoprotein in melanoma and colon cancer. Importantly, these studies were conducted using in vitro cell line models and the role of CDK8 in tumourigenesis in vivo has not been explored. We have generated a mouse with a Cdk8 conditional knockout allele and examined the consequences of Cdk8 loss on normal tissue homeostasis and tumour development in vivo. Cdk8 deletion in the young adult mouse did not induce any gross or histopathological abnormalities, implying that Cdk8 is largely dispensable for somatic cellular homeostasis. In contrast, Cdk8 deletion in the Apc(Min) intestinal tumour model shortened the animals' survival and increased tumour burden. Although Cdk8 deletion did not affect tumour initiation, intestinal tumour size and growth rate were significantly increased in Cdk8-null animals. Transcriptome analysis performed on Cdk8-null intestinal cells revealed up-regulation of genes that are governed by the Polycomb group (PcG) complex. In support of these findings, Cdk8-null intestinal cells and tumours displayed a reduction in histone H3K27 trimethylation, both globally and at the promoters of a number of PcG-regulated genes involved in oncogenic signalling. Together, our findings uncover a tumour suppressor function for CDK8 in vivo and suggest that the role of CDK8 activity in driving oncogenesis is context-specific. Sequencing data were deposited at GEO (Accession No. GSE71385).

  3. [Diurnal variations of greenhouse gas fluxes at the water-air interface of aquaculture ponds in the Min River estuary].

    Science.gov (United States)

    Yang, Ping; Tong, Chuan; He, Qing-Hua; Huang, Jia-Fang

    2012-12-01

    Wetland reclamation and aquaculture is one of the main disturbance types in coastal wetlands. Diurnal variations of CO2, CH4 and N2O fluxes at the water-air interface were determined using a floating chambers + gas chromatography method in a shrimp pond, and a mixed culture pond of fish and shrimp in October in the Shanyutan Wetland of the Min River estuary, southeast China. Meanwhile, the meteorological indicators in ground surface and physical, chemical and biological indicators of surface water were also measured. CO2, CH4 and N2O fluxes at the water-air interface all demonstrated distinct diurnal variations. Both shrimp pond and mixed culture pond of fish and shrimp functioned as a sink of CO2 [the diurnal averaged CO2 fluxes were -48.79 and -105.25 mg x (m2 x h)(-1), respectively], and a source of CH4 [the diurnal averaged CH4 fluxes were 1.00 and 5.74 mg x (m2 x h)(-1), respectively]; the diurnal averaged CO2 and CH4 fluxes at the water-air interface of the mixed culture of fish and shrimp pond were higher than that of the shrimp pond. Greenhouse gas fluxes at the water-air interface from the aquaculture ponds were influenced by many factors. Multiple stepwise regression analysis showed that the concentration of Chlorophyll was the major factor affecting the CO2 fluxes, and the concentrations of SO4(2-) and PO4(3-) were the major factors affecting the CH4 fluxes at the water-air interface of the shrimp pond; whereas water temperature and Chlorophyll were the major factors affecting the CO2 fluxes, and dissolved oxygen, PO4(3-) and pH were the major factors affecting the CH4 fluxes at the water-air interface of the mixed culture pond of fish and shrimp. PMID:23379142

  4. Monitoring of 1-min personal particulate matter exposures in relation to voice-recorded time-activity data.

    Science.gov (United States)

    Quintana, P J; Valenzia, J R; Delfino, R J; Liu, L J

    2001-12-01

    Recent studies on the association between exposures to airborne particulate matter (PM) and disease have identified short-term peaks in PM exposures as posing especial health threats. Lightweight personal instruments are needed to characterize short-term exposures to PM and to identify the most important sources of high PM excursions. In this study, we measured exposure to fine PM using a small personal nephelometer (pDR; MIE, Inc) to investigate the utility of this instrument in identifying activities and microenvironments most associated with high PM exposures and the magnitude and duration of peaks in PM exposures. Ten adult volunteers wore a pDR recording PM concentrations at 1-min time intervals for 1 week each. PM concentrations were measured by the pDR in units of microg/m(3) based on light scatter. The use of a time-stamped voice recorder enabled activity and location to be continuously documented in real time. In addition, a small, inexpensive light intensity logger was affixed to the pDR to evaluate the potential of this instrument to assist in verifying wearer- recorded data. For each person, patterns of PM exposure were remarkably consistent over daily activities and showed large excursions associated with specific indoor and outdoor microenvironments and activities, such as cooking. When the magnitude and duration of excursions in PM were analyzed, we found that high PM levels occurred in relatively few of the minutes measured but comprised a substantial fraction of the total exposure to PM. Fifteen-minute averaged PM levels were found to be as much as 10 times the daily average. When the data were analyzed with a generalized estimating equation model to account for effects of autocorrelation and clustering, PM exposure was significantly higher during subject-reported events including barbeque, yard work, being near pets or construction activities, cooking, and environmental tobacco smoke exposure, as compared with periods with no pollution events

  5. Assimilation and Syneresis of Inland Min Dialects%内陆闽语的同化与合音现象

    Institute of Scientific and Technical Information of China (English)

    邓享璋

    2012-01-01

    The assimilation of inland Min dialects are usually found in a syllable or between the neighboring syllables. The analogy of neighboring dialects and the influence of common language can also act as an influence. Some words may undergo changes in meaning after the assimilation. The syneresis usually takes the initial of the first syllable and the (medial- final and) tone of the second syllable and thus form a new syllable which usually conforms to the dialect's phonological system. There are often no meaning changes involved after the syneresis. Syneresis forms are often found in the frequently used words or phrases in daily life, some of which cannot be independently used. The syneresis syllable is written as one homophone character, which is sometimes newly coined. The assimilations may not emerge and the syneresis syllables may undergo variation in order to avoid semantic confusion caused by homophony.%内陆闽语的同化现象一般发生于音节内部、相邻的音节之间和语言的子系统内部,也表现在相邻方言间的类推和共同语对方言的影响。有的同化发生前后的语音形式意义有所不同。内陆闽语的合音,从语音看,遵循的是反切式的拼合方式,即“前字声母+(前字介音+后字韵母)+后字声调→合音音节”;合音音节一般不超出该方言的语音系统。从语义看,合音形式与组成它的原词并无二致。从语用看,合音形式均为口语中反映日常生活的高频词或短语,有的不能独立运用。书面形式上,一般用同音字或另造俗字。为避免影响辨义,同化是否发生存在变数,合音音节也时常发生变异。

  6. A Nucleus-encoded Topological Specificity Factor PpMinE in Physcomitrella patens has Conserved Function Similar to Its Chloroplast-encoded Ancestor%小立碗藓叶绿体分裂相关基因PpMinE的克隆及其功能与进化分析

    Institute of Scientific and Technical Information of China (English)

    朱佳瑛; 刘维仲; 周伟巍; 胡勇; 何奕昆

    2007-01-01

    用RT-PCR技术从小立碗藓中(Physcomitrella patens)克隆了核编码的MinE基因,命名为PpMinE,并克隆了该基因的基因组DNA.序列比对显示该基因编码的蛋白质与真细菌和绿藻叶绿体编码的MinE蛋白具有较高的相似性.pMinE-EGFP融合蛋白在烟草中的瞬时表达证明该蛋白定位于叶绿体内.在大肠杆菌中过量表达PpMinE导致细胞不正常分裂,产生无染色体的小细胞,这表明MinE的功能在进化上是保守的.在系统发育树中,PpMinE和高等陆生植物有较近的亲缘关系.在已知的陆生植物的叶绿体基因组中没有找到MinE的同源蛋白,这暗示在进化过程中MinE从叶绿体到细胞核的水平转移可能发生在陆生植物发生以前.%A nucleus-encoded MinE gene, designated PpMinE, from Physcomitrella patens was identified using RT-PCR. The presence of both N- and C-terminal extensions in PpMinE protein suggested its cyanobacterial origin. The transient expression of PpMinE using green fluorescent protein fusion in tobacco (Nicotiana tabacum L.) indicated that the PpMinE was a chloroplast-targeted protein. Overexpression of PpMinE in Escherichia coli caused division site misplacement and minicell formation, suggesting evolutionary functional conservation of MinE during plant phylogenesis. According to the phylogenetic tree, PpMinE protein has a close relationship with the highland plants, which suggests that the transfer events of MinE gene from plastid to nucleus might have occurred before the origin of the land plants.

  7. Modeling of the dynamic pole-to-pole oscillations of the min proteins in bacterial cell division: The effect of an external field

    CERN Document Server

    Modchang, C; Triampo, W; Ngamsaad, W; Nuttawut, N; Tang, I M; Lenbury, Y; Modchang, Charin; Kanthang, Paisan; Triampo, Wannapong; Ngamsaad, Waipot; Nuttawut, Narin; Lenbury, Yongwimol

    2004-01-01

    One of the most important steps in the developmental process of the bacteria cell at the cellular level is the determination of the middle of the cell and the proper placement of the septum, these being essential to the division of the cell. In E. coli, this step depends on the proteins MinC, MinD, and MinE. Exposure to a constant electric field may cause the bacteria cell division mechanism to change, resulting in an abnormal cytokinesis. To see the effects of an external field e.g., an electric or magnetic field on this process, we have solved a set of deterministic reaction diffusion equations, which incorporate the influence of an electric field. We have found some changes in the dynamics of the oscillations of the min proteins from pole to pole. The numerical results show some interesting effects, which are qualitatively in good agreement with some experimental results.

  8. Liver fatty acid-binding protein (L-Fabp) modifies intestinal fatty acid composition and adenoma formation in ApcMin/+ mice.

    Science.gov (United States)

    Dharmarajan, Sekhar; Newberry, Elizabeth P; Montenegro, Grace; Nalbantoglu, Ilke; Davis, Victoria R; Clanahan, Michael J; Blanc, Valerie; Xie, Yan; Luo, Jianyang; Fleshman, James W; Kennedy, Susan; Davidson, Nicholas O

    2013-10-01

    Evidence suggests a relationship between dietary fat intake, obesity, and colorectal cancer, implying a role for fatty acid metabolism in intestinal tumorigenesis that is incompletely understood. Liver fatty acid-binding protein (L-Fabp), a dominant intestinal fatty acid-binding protein, regulates intestinal fatty acid trafficking and metabolism, and L-Fabp deletion attenuates diet-induced obesity. Here, we examined whether changes in intestinal fatty acid metabolism following L-Fabp deletion modify adenoma development in Apc(Min)(/+) mice. Compound L-Fabp(-/-)Apc(Min)(/+) mice were generated and fed a 10% fat diet balanced equally between saturated, monounsaturated, and polyunsaturated fat. L-Fabp(-/-)Apc(Min)(/+) mice displayed significant reductions in adenoma number and total polyp area compared with Apc(Min)(/+)controls, reflecting a significant shift in distribution toward smaller polyps. Adenomas from L-Fabp(-/-)Apc(Min)(/+) mice exhibited reductions in cellular proliferation, high-grade dysplasia, and nuclear β-catenin translocation. Intestinal fatty acid content was increased in L-Fabp(-/-)Apc(Min)(/+) mice, and lipidomic profiling of intestinal mucosa revealed significant shifts to polyunsaturated fatty acid species with reduced saturated fatty acid species. L-Fabp(-/-)Apc(Min)(/+) mice also showed corresponding changes in mRNA expression of enzymes involved in fatty acid elongation and desaturation. Furthermore, adenomas from L-Fabp(-/-)Apc(Min)(/+) mice displayed significant reductions in mRNA abundance of nuclear hormone receptors involved in cellular proliferation and in enzymes involved in lipogenesis. These findings collectively implicate L-Fabp as an important genetic modifier of intestinal tumorigenesis, and identify fatty acid trafficking and metabolic compartmentalization as an important pathway linking dietary fat intake, obesity, and intestinal tumor formation.

  9. The modifier of Min 2 (Mom2) locus: Embryonic lethality of a mutation in the Atp5a1 gene suggests a novel mechanism of polyp suppression

    OpenAIRE

    Baran, Amy A.; Silverman, Karen A.; Zeskand, Joseph; Koratkar, Revati; Palmer, Ashley; McCullen, Kristen; Curran, Walter J.; Edmonston, Tina Bocker; Linda D. Siracusa; Buchberg, Arthur M.

    2007-01-01

    Inactivation of the APC gene is considered the initiating event in human colorectal cancer. Modifier genes that influence the penetrance of mutations in tumor-suppressor genes hold great potential for preventing the development of cancer. The mechanism by which modifier genes alter adenoma incidence can be readily studied in mice that inherit mutations in the Apc gene. We identified a new modifier locus of ApcMin-induced intestinal tumorigenesis called Modifier of Min 2 (Mom2). The polyp-resi...

  10. AREVA announces US$ 7.75 Per share friendly cash offer for UraMin; Offre publique d'achat amicale d'AREVA sur UraMin sur la base d'un prix de 7,75US$ par action

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2007-07-01

    AREVA and UraMin Inc. ('UraMin') entered on June 15, 2007 into an agreement in respect of AREVA's friendly cash offer for 100% of the share capital of UraMin. UraMin is listed in London (AIM) and Toronto (TSX). AREVA (Euronext Paris) already owns 5.5% of UraMin's share capital. This cash offer of AREVA will be made through its indirect wholly-owned subsidiary CFMM Development ('AREVA') based on a price of US$ 7.75 per UraMin share. The total offer consideration amounts to more than USD 2.5 billion for 100% of the fully diluted share capital of UraMin. This represents a premium of 21% over UraMin 20-day weighted average trading price ending on June 8, 2007. The UraMin Board of Directors, after consulting with its financial advisors, has determined that the offer is fair and in the best interest of the UraMin shareholders and it has resolved to recommend acceptance of the Offer. BMO Capital Markets has provided an opinion that the offer is fair, from a financial point of view, to the UraMin shareholders. In connection with the offer, all directors and certain other shareholders representing approximately 25% of the outstanding UraMin shares (calculated on a fully diluted basis) have entered into lock-up agreements with AREVA pursuant to which they have agreed to tender all their UraMin shares to AREVA's offer. The support agreement entered into between AREVA and UraMin provides for, among other things, in case a superior proposal is accepted by UraMin, a right to match in favour of AREVA. The support agreement also includes a break up fee in favour of AREVA of US$ 75 million under certain circumstances. Concurrently with the closing of the proposed offer, UraMin will declare a dividend payable in shares of the capital of Niger Uranium Limited held by UraMin (where permitted by law) or a cash equivalent of the value of such shares.

  11. Yi-Qi-Zeng-Min-Tang,a Chinese medicine,ameliorates insulin resistance in type 2 diabetic rats

    Institute of Scientific and Technical Information of China (English)

    Zeng Zhang; Hong-Li Xue; Yi Liu; Wen-Jian Wang

    2011-01-01

    AIM:To investigate the effects of the Chinese herbal decoction,Yi-Qi-Zeng-Min-Tang (YQZMT),on insulin resistance in type 2 diabetic rats. METHODS:Sprague-Dawley rats were divided into two dietary regiments by feeding either normal pellet diet (NPD) or high fat diet (HFD).Four weeks later,the HFD-fed rats were injected intraperitoneally with lowdose streptozotocin (STZ).Rats with non-fasting blood glucose level ≥ 16.67 mmol/L were considered type 2 diabetic and further divided into five subgroups:the type 2 diabetes model group,low-dose,medium-dose and high-dose YQZMT groups,and rosiglitazone group. Age-matched NPD-fed rats served as controls.YQZMT or rosiglitazone were administered for 8 wk.Intraperitoneal glucose and insulin tolerance tests were performed before and after the treatment to measure the glucose tolerance and insulin sensitivity.Serum levels of biochemical parameters,adipocytokines,such as tumor necrosis factor-α (TNF-α),interleukin-6 (IL-6),as well as free fatty acids (FFAs),were also analyzed. RESULTS:There was significant elevation of insulin resistance and serum levels of fasting glucose (12.82 ± 1.08 mmol/L vs 3.60 ± 0.31 mmol/L,P < 0.01),insulin (7197.36 ± 253.89 pg/mL vs 4820.49 ± 326.89 pg/mL, P < 0.01),total cholesterol (TC) (8.40 ± 0.49 mmol/L vs 2.14 ± 0.06 mmol/L,P < 0.01),triglyceride (2.24 ± 0.12 mmol/L vs 0.78 ± 0.05 mmol/L,P < 0.01),low-density lipoprotein cholesterol (LDL-c) (7.84 ± 0.51 mmol/L vs 0.72 ± 0.04 mmol/L,P < 0.01) and decrease in high-density lipoprotein cholesterol (HDL-c) (0.57 ± 0.03 mmol/L vs 1.27 ± 0.03 mmol/L,P < 0.01) in the low-dose STZ and high-fat diet induced type 2 diabetic group when compared with the control group. Administration of YQZMT induced dose- and timedependent changes in insulin resistance,glucose and lipid profile,and reduced levels of FFA,TNF-α and IL-6 in the type 2 diabetic rats.After the treatment, compared with the diabetic group,the insulin resistance was ameliorated in the

  12. Protective effects of ischemic preconditioning and application of lipoic acid prior to 90 min of hepatic ischemia in a rat model

    Institute of Scientific and Technical Information of China (English)

    Friedrich Duenschede; Ines Gockel; Alexandra K Kiemer; Theodor Junginger; Kirsten Erbes; Nina Riegler; Patrick Ewald; Achim Kircher; Stefanie Westermann; Arno Schad; Imke Miesmer; Simon Albrecht-Sch(o)ck

    2007-01-01

    AIM: To compare different preconditioning strategies to protect the liver from ischemia/reperfusion injury focusing on the expression of pro- and anti-apoptotic proteins. Interventions comprised different modes of ischemic preconditioning (IP) as well as pharmacologic pretreatment by αα-lipoic acid (LA).METHODS: Several groups of rats were compared:sham operated animals, non-pretreated animals (nt),animals receiving IP (10 min of ischemia by clamping of the portal triad and 10 min of reperfusion) prior to sustained ischemia, animals receiving selective ischemic preconditioning (IPsel, 10 min of ischemia by selective clamping of the ischemic lobe and 10 min of reperfusion)prior to sustained ichemia, and animals receiving 500μmol α-LA injected i.v. 15 min prior to the induction of 90 min of selective ischemia.RESULTS: Cellular damage was decreased only in the LA group. TUNEL-positive hepatocytes as well as necrotic hepatocyte injury were also decreased only by LA (19±2 vs 10±1, P<0.05 and 29±5 vs 12±1,P<0.05). Whereas caspase 3- activities in liver tissue were unchanged, caspase 9- activity in liver tissue was decreased only by LA pretreatment (3.1±0.3 vs 1.8±0.2, P<0.05). Survival rate as the endpoint of liver function was increased after IP and LA pretreatment but not after IPsel. Levels of lipid peroxidation (LPO) in liver tissue were decreased in the IP as well as in the LA group compared to the nt group. Determination of pro- and anti-apoptotic proteins showed a shift towards anti-apoptotic proteins by LA. In contrast, both our IP strategies failed to influence apototic cell death.CONCLUSION: IP, consisting of 10 min of ischemia and 10 min of reperfusion, protects only partly against ischemia/reperfusion injury of the liver prior to 90 min of selective ischemia. IPsel did not influence ischemic tolerance of the liver. LA improved tolerance to ischemia,possibly by downregulation of pro-apoptotic Bax.

  13. Study on Min Ziqian's date of birth and family background%闵子骞生年及家庭出身考辨

    Institute of Scientific and Technical Information of China (English)

    单冬冬

    2016-01-01

    Min Ziqian has been respected as a Confucian sage and moral model both officially and non-governmentally in the past 2,000 years. But he was little mentioned in historical literature. Knowledge about his date of birth and family background depends only on Min Genealogy and local chronicles. About the date of birth and family background, there are two kinds of view. One holds that Min Ziqian was born in the fifth year after Luzhao Gong was in power, was the son of Min Mafu who was Dafu of Lu. The other suggests that Min was born in the seventh year after Luzhao Gong was in power and the son of Min Zhongbin who was Weili of Lu. My study shows Min Ziqian was born in the fifth year after Luzhao Gong was in power, but the statement that he was the son of Min Mafu is wrong, the statement that he was the son of Min Zhongbin is more convincing.%二千余年来,闵子骞作为儒家先贤、道德楷模,无论在官方还是在民间都备受尊崇。然而由于史料中关于闵子骞的记载较少,对于闵子骞生年、家庭出身等问题的认识往往只能简单依据现存的闵氏宗谱、地方志等,史料来源较为单一,且颇多矛盾之处。目前关于闵子骞生年与出身有两种说法:一种是闵子骞生于鲁昭公五年,系鲁国大夫闵马父之子;另一种是闵子骞生于鲁昭公七年,系鲁国委吏闵仲滨之子。通过考证,可以确定闵子骞生于鲁昭公五年,但其系闵马父之子的说法有误,其系鲁国委吏闵仲滨之子的说法则更为可信。

  14. Estrogen receptor α or β loss in the colon of Min/+ mice promotes crypt expansion and impairs TGFβ and HNF3β signaling.

    Science.gov (United States)

    Hasson, Rian M; Briggs, Alexandra; Carothers, Adelaide M; Davids, Jennifer S; Wang, Jiping; Javid, Sara H; Cho, Nancy L; Bertagnolli, Monica M

    2014-01-01

    Adenomatous polyposis coli (APC)-regulated Wnt and transforming growth factor-β (TGFβ) signaling cooperate in the intestine to maintain normal enterocyte functions. Human clinical trials showed that estrogen [17β-estradiol (E2)], the ligand of nuclear receptors estrogen receptor α (ERα) and ERβ, inhibited colorectal cancer (CRC) in women. Consistent with this finding, we reported that E2, ERα and ERβ suppressed intestinal tumorigenesis in the C57BL/6J-Min/+ (Min/+) mouse, a CRC model. Here, we extended our results with further comparisons of colon and small intestine from intact female Apc (+/+) (WT), Min/+ and ER-deficient Min/+ mice. In the colon of ER-deficient Min/+ mice, ER loss reduced TGFβ signaling in crypt base cells as evidenced by minimal expression of the effectors Smad 2, 3 and 4 in these strains. We also found reduced expression of Indian hedgehog (Ihh), bone morphogenetic protein 4 and hepatocyte nuclear factor 3β or FoxA2, factors needed for paracrine signaling between enterocytes and mesenchyme. In proximal colon, ER loss produced a >10-fold increased incidence of crypt fission, a marker for wound healing and tumor promotion. These data, combined with our previous work detailing the specific roles of E2, ERα and ERβ in the colon, suggest that ER activity helps to maintain the intestinal stem cell (ISC) microenvironment by modulating epithelial-stromal crosstalk in ways that regulate cytokine, Wnt and Ihh availability in the extracellular matrix (ECM). PMID:24104551

  15. Nuclear data for cyclotron production of 114mIn/114In and 140Nd/140Pr used in gamma camera monitoring, RIT, ERT and PET

    International Nuclear Information System (INIS)

    Aim of the presented study is to compare the calculated cross sections for the production of 140Nd/140Pr and 114mIn/114In via different reactions with incident particle energy up to 50 MeV as a part of systematic studies on particle-induced activations on metal target, theoretical calculation of production yield, calculation of target thickness requirement and suggestion for optimum reaction to produce Neodymium-140 and Indium-114m. 140Nd/140Pr and 114mIn/114In excitation functions via natCe(3He,xn)140Nd → 140Pr, 141Pr(p,2n)140Nd → 140Pr, 141Pr(d,3n)140Nd → 140Pr, 114Cd(p,n)114mIn → 114In, 114Cd(d,2n)114mIn → 114In and 116Cd(p,3n)114mIn → 114In reactions were calculated by ALICE/91, ALICE/ASH (GDH Model and Hybrid Model) and TALYS-1.2 (Equilibrium and Pre-Equilibrium) codes and compared to existing data. (orig.)

  16. The Miniature X-ray Solar Spectrometer (MinXSS) CubeSats: spectrometer characterization techniques, spectrometer capabilities, and solar science objectives

    CERN Document Server

    Moore, Christopher S; Caspi, Amir; Mason, James P

    2016-01-01

    The Miniature X-ray Solar Spectrometer (MinXSS) are twin 3U CubeSats. The first of the twin CubeSats (MinXSS-1) launched in December 2015 to the International Space Station for deployment in mid-2016. Both MinXSS CubeSats utilize a commercial off the shelf (COTS) X-ray spectrometer from Amptek to measure the solar irradiance from 0.5 to 30 keV with a nominal 0.15 keV FWHM spectral resolution at 5.9 keV, and a LASP-developed X-ray broadband photometer with similar spectral sensitivity. MinXSS design and development has involved over 40 graduate students supervised by professors and professionals at the University of Colorado at Boulder. The majority of previous solar soft X-ray measurements have been either at high spectral resolution with a narrow bandpass or spectrally integrating (broadband) photometers. MinXSS will conduct unique soft X-ray measurements with moderate spectral resolution over a relatively large energy range to study solar active region evolution, solar flares, and the effects of solar soft ...

  17. A local and renormalizable framework for the gauge-invariant operator $A^2_{\\min}$ in Euclidean Yang-Mills theories in linear covariant gauges

    CERN Document Server

    Fiorentini, M A L Capri D; Mintz, B W; Palhares, L F; Sorella, S P

    2016-01-01

    We address the issue of the renormalizability of the gauge-invariant non-local dimension-two operator $A^2_{\\rm min}$, whose minimization is defined along the gauge orbit. Despite its non-local character, we show that the operator $A^2_{\\rm min}$ can be cast in local form through the introduction of an auxiliary Stueckelberg field. The localization procedure gives rise to an unconventional kind of Stueckelberg-type action which turns out to be renormalizable to all orders of perturbation theory. In particular, as a consequence of its gauge invariance, the anomalous dimension of the operator $A^2_{\\rm min}$ turns out to be independent from the gauge parameter $\\alpha$ entering the gauge-fixing condition, being thus given by the anomalous dimension of the operator $A^2$ in the Landau gauge.

  18. Protection of Military Vehicles Against Mine Threats and Improvised Explosive Devices / Ochrona Pojazdów Wojskowych Przed Wybuchem Min i Improwizowanych Urządzeń Wybuchowych

    Directory of Open Access Journals (Sweden)

    Niezgoda Tadeusz

    2015-09-01

    Full Text Available Pojazdy wojskowe są narażone na działanie m.in. fali wybuchowej min oraz improwizowanych urządzeń wybuchowych IED (z ang. improvised explosive device. Dotychczasowe rozwiązania konstrukcyjne pancerzy pojazdów wojskowych nie zapewniają ich ochrony na maksymalnym poziomie. W publikacji przedstawiono rozwiązania konstrukcyjne, których celem jest zwiększenie odporności pojazdów wojskowych na eksplozję ładunków wybuchowych. Ponadto scharakteryzowano wymagania dotyczące odporności pojazdów wojskowych na wybuch min i urządzeń IED. Przedstawiono również przykładowe wyniki badań paneli energochłonnych oraz sformułowane na ich podstawie wnioski do dalszego rozwoju konstrukcji ochronnych.

  19. Fast-ion transport in q{sub min}>2, high-β steady-state scenarios on DIII-D

    Energy Technology Data Exchange (ETDEWEB)

    Holcomb, C. T. [Lawrence Livermore National Laboratory, Livermore, California 94551 (United States); Heidbrink, W. W.; Collins, C. [Department of Physics and Astronomy, University of California Irvine, Irvine, California 92697 (United States); Ferron, J. R.; Van Zeeland, M. A.; Garofalo, A. M.; Bass, E. M.; Luce, T. C.; Pace, D. C. [General Atomics, P.O. Box 85608, San Diego, California 92186-5608 (United States); Solomon, W. M.; Mueller, D.; Grierson, B.; Podesta, M. [Princeton Plasma Physics Laboratory, P.O. Box 451, Princeton, New Jersey 05843 (United States); Gong, X.; Ren, Q. [Institute of Plasma Physics, Chinese Academy of Sciences, Hefei, Anhui 230031 (China); Park, J. M.; Kim, K. [Oak Ridge National Laboratory, P.O. Box 2008, Oak Ridge, Tennessee 37831 (United States); Turco, F. [Columbia University, 2960 Broadway, New York, New York 10027 (United States)

    2015-05-15

    Results from experiments on DIII-D [J. L. Luxon, Fusion Sci. Technol. 48, 828 (2005)] aimed at developing high β steady-state operating scenarios with high-q{sub min} confirm that fast-ion transport is a critical issue for advanced tokamak development using neutral beam injection current drive. In DIII-D, greater than 11 MW of neutral beam heating power is applied with the intent of maximizing β{sub N} and the noninductive current drive. However, in scenarios with q{sub min}>2 that target the typical range of q{sub 95}= 5–7 used in next-step steady-state reactor models, Alfvén eigenmodes cause greater fast-ion transport than classical models predict. This enhanced transport reduces the absorbed neutral beam heating power and current drive and limits the achievable β{sub N}. In contrast, similar plasmas except with q{sub min} just above 1 have approximately classical fast-ion transport. Experiments that take q{sub min}>3 plasmas to higher β{sub P} with q{sub 95}= 11–12 for testing long pulse operation exhibit regimes of better than expected thermal confinement. Compared to the standard high-q{sub min} scenario, the high β{sub P} cases have shorter slowing-down time and lower ∇β{sub fast}, and this reduces the drive for Alfvénic modes, yielding nearly classical fast-ion transport, high values of normalized confinement, β{sub N}, and noninductive current fraction. These results suggest DIII-D might obtain better performance in lower-q{sub 95}, high-q{sub min} plasmas using broader neutral beam heating profiles and increased direct electron heating power to lower the drive for Alfvén eigenmodes.

  20. Lack of anti-tumor activity with the β-catenin expression inhibitor EZN-3892 in the C57BL/6J Min/+ model of intestinal carcinogenesis

    Energy Technology Data Exchange (ETDEWEB)

    Hasson, Rian M.; Briggs, Alexandra; Rizvi, Hira; Carothers, Adelaide M.; Davids, Jennifer S.; Bertagnolli, Monica M.; Cho, Nancy L., E-mail: nlcho@partners.org

    2014-02-14

    Highlights: • Wnt/β-catenin signaling is aberrantly activated in most colorectal cancers. • Locked nucleic acid (LNA)-based antisense is a novel tool for cancer therapy. • β-Catenin inhibition was observed in mature intestinal tissue of LNA-treated mice. • Further investigation of Wnt/β-catenin targeted therapies is warranted. - Abstract: Background: Previously, we showed that short-term inhibition of β-catenin expression and reversal of aberrant β-catenin subcellular localization by the selective COX-2 inhibitor celecoxib is associated with adenoma regression in the C57BL/6J Min/+ mouse. Conversly, long-term administration resulted in tumor resistance, leading us to investigate alternative methods for selective β-catenin chemoprevention. In this study, we hypothesized that disruption of β-catenin expression by EZN-3892, a selective locked nucleic acid (LNA)-based β-catenin inhibitor, would counteract the tumorigenic effect of Apc loss in Min/+ adenomas while preserving normal intestinal function. Materials and methods: C57BL/6J Apc{sup +/+} wild-type (WT) and Min/+ mice were treated with the maximum tolerated dose (MTD) of EZN-3892 (30 mg/kg). Drug effect on tumor numbers, β-catenin protein expression, and nuclear β-catenin localization were determined. Results: Although the tumor phenotype and β-catenin nuclear localization in Min/+ mice did not change following drug administration, we observed a decrease in β-catenin expression levels in the mature intestinal tissue of treated Min/+ and WT mice, providing proof of principle regarding successful delivery of the LNA-based antisense vehicle. Higher doses of EZN-3892 resulted in fatal outcomes in Min/+ mice, likely due to β-catenin ablation in the intestinal tissue and loss of function. Conclusions: Our data support the critical role of Wnt/β-catenin signaling in maintaining intestinal homeostasis and highlight the challenges of effective drug delivery to target disease without permanent

  1. Lignan precursors from flaxseed or rye bran do not protect against the development of intestinal neoplasia in Apc(Min) mice

    DEFF Research Database (Denmark)

    van Kranen, H.J.; Mortensen, Alicja; Sørensen, Ilona Kryspin;

    2003-01-01

    Phytoestrogens, like isoflavonoids and lignans, have been postulated as possible colorectal cancer protective constituents. To investigate this hypothesis, two high-fiber sources rich in lignan precursors, i.e., rye bran and flaxseed, were tested for their ability to modulate intestinal tumor...... development in Apc(Min) mice. Test diets consisted of a control diet (a Westem-style diet, adjusted for fiber and/or phytate content) supplemented with 5% flaxseed or 30% rye bran. Chemical analysis of diets and blood samples confirmed the enhanced systemic exposure of mice fed the test diets to the major...... model for intestinal neoplasia such as the Apc(Min) mice....

  2. Evaluation of mosaic pattern areas in HRCT with Min-IP reconstructions in patients with pulmonary hypertension: Could this evaluation replace lung perfusion scintigraphy?

    International Nuclear Information System (INIS)

    Purpose: The aim of this study is to evaluate a possible correlation between areas of lung attenuation, found in minimum intensity projection (Min-IP) reconstruction images performed with high resolution computed tomography without contrast medium (HRCT), and areas of lung perfusion alteration, found in lung perfusion scintigraphy (LPS). Materials and methods: Two independent radiologists, unaware of LPS results, evaluated retrospectively a group of 113 patients affected by pulmonary hypertension (HP) of different aetiology. These have been examined in a period of two years in our centre both by spiral computed tomography (CT) with and without contrast-medium and by LPS. The final diagnosis was determined on clinical data, right heart catheterisation and contrast enhanced CT in angiographic phase (CTPA). We reconstructed the Min-IP images of lung parenchyma in all the cases both in HRCT without contrast-medium, and in contrast enhanced CT in angiographic phase (CTPA) in axial, sagittal and coronal planes. The obtained images were qualitatively graded into three categories of pulmonary attenuation: homogeneous, inhomogeneous with non-segmental patchy defects, inhomogeneous with segmental defects. The same criteria of classification were used also for LPS images. In the group of patients with chronic thromboembolic pulmonary hypertension (CTEPH) we also compared the number of areas of lung attenuation found in Min-IP images in HRCT without contrast-medium, and their exact localization, with not perfused areas in LPS. Gold standard for the diagnosis of pulmonary embolism was spiral contrast enhanced CT in angiographic phase (CTPA). Results: In all cases we found exact correspondence between the Min-IP images in HRCT with and without contras agent. The attenuation pattern seen on Min-IP images was concordant with those of LPS in 96 out of 113 patients (85%). In the remaining 17 cases (15%) it was discordant: in 12 cases inhomogeneous in Min-IP images (7 with non

  3. Complicating Culture and Difference: Situating Asian American Youth Identities in Lisa Yee's "Millicent Min," "Girl Genius" and "Stanford Wong Flunks Big-Time"

    Science.gov (United States)

    Endo, Rachel

    2009-01-01

    This review situates how culture, difference, and identity are discursively constructed in "Millicent Min, Girl Genius" and "Stanford Wong Flunks Big-Time," two award-winning books written by critically acclaimed Asian American author Lisa Yee. Using contextual literacy approaches, the characters, cultural motifs, and physical settings in these…

  4. Serotonin- and Dopamine-Related Gene Expression in db/db Mice Islets and in MIN6 β-Cells Treated with Palmitate and Oleate

    Science.gov (United States)

    Cataldo, L. R.; Olmos, P.; Galgani, J. E.; Valenzuela, R.; Aranda, E.; Cortés, V. A.; Santos, J. L.

    2016-01-01

    High circulating nonesterified fatty acids (NEFAs) concentration, often reported in diabetes, leads to impaired glucose-stimulated insulin secretion (GSIS) through not yet well-defined mechanisms. Serotonin and dopamine might contribute to NEFA-dependent β-cell dysfunction, since extracellular signal of these monoamines decreases GSIS. Moreover, palmitate-treated β-cells may enhance the expression of the serotonin receptor Htr2c, affecting insulin secretion. Additionally, the expression of monoamine-oxidase type B (Maob) seems to be lower in islets from humans and mice with diabetes compared to nondiabetic islets, which may lead to increased monoamine concentrations. We assessed the expression of serotonin- and dopamine-related genes in islets from db/db and wild-type (WT) mice. In addition, the effect of palmitate and oleate on the expression of such genes, 5HT content, and GSIS in MIN6 β-cell was determined. Lower Maob expression was found in islets from db/db versus WT mice and in MIN6 β-cells in response to palmitate and oleate treatment compared to vehicle. Reduced 5HT content and impaired GSIS in response to palmitate (−25%; p < 0.0001) and oleate (−43%; p < 0.0001) were detected in MIN6 β-cells. In conclusion, known defects of GSIS in islets from db/db mice and MIN6 β-cells treated with NEFAs are accompanied by reduced Maob expression and reduced 5HT content. PMID:27366756

  5. 114mIn, a candidate for radionuclide therapy: low-energy cyclotron production and labeling of DTPA-D-Phe-octreotide

    International Nuclear Information System (INIS)

    A method for production of carrier-free 114mIn (half-life 49.5 days), which is a potential radionuclide for radionuclide therapy of slowly growing tumors, is presented. A target consisting of five enriched cadmium (114Cd) foils, each 50 μm thick, was irradiated by protons (from 12.6-6.5 MeV) giving a target yield of 0.8 MBq/μAh. A simple and cost-efficient thermal diffusion method was used for the separation. The irradiated target foils were heated for 2 h at 306 deg. C and then etched in 0.05 M HCl. The obtained cadmium/indium solution was purified using a cation ion-exchange resin (AG 1x 8, Bio-Rad Laboratories, Hercules, CA USA). An overall yield of approximately 60% was obtained, whereas the loss of the target material was 114mIn production gave 114mIn with high specific radioactivity and was successfully used to label diethylenetriamine pentaacetic acid (DTPA)-D-Phe-octreotide. Furthermore, no difference in biodistribution between [114mIn]- and [111In]-DTPA-D-Phe1-octreotide in tumor-bearing nude mice was seen. The high radionuclide uptake in the tumors indicates a good receptor binding of the labeled octreotide

  6. The Miniature X-ray Solar Spectrometer (MinXSS) CubeSat: instrument characterization techniques, instrument capabilities and solar science objectives.

    Science.gov (United States)

    Moore, Christopher; Caspi, Amir; Woods, Thomas N.; Mason, James

    2016-05-01

    The Miniature X-ray Solar Spectrometer (MinXSS) is a 3U CubeSat launched in December 2015 to the International Space Station for deployment in early 2016. MinXSS will utilize a commercial off the shelf (COTS) X-ray spectrometer from Amptek to measure the solar irradiance from 0.5 - 30 keV with a nominal 0.15 keV FWHM spectral resolution at 5.9 keV and a LASP developed X-ray photometer with similar spectral sensitivity. MinXSS design and development has involved over 40 graduate students supervised by professors and professionals at the University of Colorado at Boulder.The majority of previous solar X-ray measurements have been either at high spectral resolution with a narrow bandpass or spectrally integrating (broad band) photometers. MinXSS will conduct unique soft X-ray measurements of moderate spectral resolution over a relatively large energy range to study solar active region evolution, solar flares, and their effects on Earth’s ionosphere. This presentation focuses on the science instrument characterization involving radioactive X-ray sources and the National Institute for Standard and Technology (NIST) Synchrotron Ultraviolet Radiation Facility (SURF). Detector spectral response, spectral resolution, response linearity are discussed as well as future solar science objectives.

  7. A Study on the Construction of Ecological Protective Screen System in the Arid Valley Area of the Upper Reaches of the Min River

    Institute of Scientific and Technical Information of China (English)

    Zhao Bin

    2015-01-01

    The Min River is a large tributary in the upper reaches of the Yangtze River. Its source is the south range of the Min Mountains in the area where Sichuan and Gansu share a bounda ̄ry. The area consists of five counties in the Aba Tibetan-Qiang Autonomous Prefecture, including Wenchuan, Lixian, Maoxian, Songpan, and He ̄ishui. The area covers 25,426 square kilometers. The area in the upper reaches of the Min River is an arid valley, and its ecological position is very important. This area is not only one that is home to world heritage and national scenic spots, but it is also a poor ethnic minority area with relatively backward economic conditions. Moreover,it is also an important ecological screen and water source for the Chengdu plain,as well as an important part of the ecological protective screen in the upper rea ̄ches of the Yangtze River. As a result of natural disasters,pressure on the carrying capacity of the population and the careless manner of economic development,the resources and environment in this area have been exploited irrationally. This has cre ̄ated a series of serious environmental problems,in ̄cluding environmental pollution, and depletion of resources,etc. Therefore, constructing an ecologi ̄cal protective screen in the upper reaches of the Min River becomes very important.

  8. The Use of the 6-Min Walk Test as a Proxy for the Assessment of Energy Expenditure during Gait in Individuals with Lower-Limb Amputation

    Science.gov (United States)

    Kark, Laurena; McIntosh, Andrew S.B; Simmons, Annea

    2011-01-01

    The objective of this study was to determine, and compare, the utility of the 6-min walk test (6 MWT) and self-selected walking speed over 15 m as proxies for the assessment of energy expenditure during gait in individuals with lower-limb amputation. Patients with unilateral, transfemoral amputation (n = 6) and patients with unilateral,…

  9. Serotonin- and Dopamine-Related Gene Expression in db/db Mice Islets and in MIN6 β-Cells Treated with Palmitate and Oleate

    Directory of Open Access Journals (Sweden)

    L. R. Cataldo

    2016-01-01

    Full Text Available High circulating nonesterified fatty acids (NEFAs concentration, often reported in diabetes, leads to impaired glucose-stimulated insulin secretion (GSIS through not yet well-defined mechanisms. Serotonin and dopamine might contribute to NEFA-dependent β-cell dysfunction, since extracellular signal of these monoamines decreases GSIS. Moreover, palmitate-treated β-cells may enhance the expression of the serotonin receptor Htr2c, affecting insulin secretion. Additionally, the expression of monoamine-oxidase type B (Maob seems to be lower in islets from humans and mice with diabetes compared to nondiabetic islets, which may lead to increased monoamine concentrations. We assessed the expression of serotonin- and dopamine-related genes in islets from db/db and wild-type (WT mice. In addition, the effect of palmitate and oleate on the expression of such genes, 5HT content, and GSIS in MIN6 β-cell was determined. Lower Maob expression was found in islets from db/db versus WT mice and in MIN6 β-cells in response to palmitate and oleate treatment compared to vehicle. Reduced 5HT content and impaired GSIS in response to palmitate (−25%; p<0.0001 and oleate (−43%; p<0.0001 were detected in MIN6 β-cells. In conclusion, known defects of GSIS in islets from db/db mice and MIN6 β-cells treated with NEFAs are accompanied by reduced Maob expression and reduced 5HT content.

  10. The Min Guo Conservatism in the Perspective of Modernity%现代性视域下的民国保守主义

    Institute of Scientific and Technical Information of China (English)

    徐旭

    2015-01-01

    The birth of the Min Guo Conservatism began with the reflection on modernization, especial-ly on westernization.The first ten years, the second ten years and the last eighteen years of Min Guo were respectively the birth period, prosperity period and maturation period of the Min Guo Conservatism.The Min Guo Conservatives opposed radicalists’ wholesale westernized scheme of establishing new-culture and ways of constructing modernization by complete imitation of western culture and abandoning tradition-al culture.But, at the same time, they contributed themselves to establishing new culture and construc-ting modernization.And in essence, the Min Guo Conservatism’ s opinions were critical discourses full of aesthetic modernity and reflective modernization.%民国保守主义的诞生始于对现代化———尤其是西方化的反思,而民国的第一个十年、第二个十年和最后十八年分别是民国保守主义的萌发期、勃兴期和成熟期。民国保守主义者反对激进主义那种全面仿习西方文化及彻底抛弃传统文化而全盘西化的新文化建构方案和现代化建设方式,但他们也同样致力于新文化建构和现代化建设。从本质上说,民国保守主义是极富审美现代性的反思现代化的批判性言说。

  11. Ergogenic Effects of Caffeine Consumption in a 3-min All-Out Arm Crank Test in Paraplegic and Tetraplegic Compared With Able-Bodied Individuals.

    Science.gov (United States)

    Flueck, Joelle Leonie; Liener, Martina; Schaufelberger, Fabienne; Krebs, Jörg; Perret, Claudio

    2015-12-01

    The aim of our study was to investigate the effect of caffeine supplementation on 3-min all-out arm crank exercise performance in paraplegic (P) and tetraplegic (T) compared with able-bodied (AB) participants. A placebo-controlled, randomized, crossover, and double-blind study design was chosen to investigate the differences between caffeine (CAF) and placebo (PLC). In total, 34 healthy, trained participants were tested. Seventeen were AB (median [minimum; maximum] VO2peak: 33.9 mL/min/kg [23.6; 57.6]), 10 were P (VO2peak: 34.4 mL/min/kg [19.5; 48.8]), and 7 were T (VO2peak: 13.6 mL/min/kg [8.6; 16.3]). All participants performed two 3-min all-out tests on an arm crank ergometer following the ingestion of either PLC or CAF. Power output parameters, plasma caffeine (PC), epinephrine (EPI), and norepinephrine (NOR) concentrations were assessed. CAF significantly increased average power over the first 30 s (p = .028) and 60 s (p = .005) in P, but not in T (p = .61; p = .87) nor in AB (p = .25; p = .44). Peak power was increased in the CAF trial in AB (+46 W) as well as in P (+21 W) but was not significantly different from PLC (AB: p = .10; P: p = .17). PC significantly increased in all groups (AB: p = .002; P: p = .005; T: p = .018) whereas EPI showed a significant increase only in AB (p = .002) and in P (p = .018). NOR increased significantly in AB (p = .018) but did not increase in the other groups. Caffeine seems to enhance short-duration exercise performance in P. In contrast, T showed a high interindividual variability and overall no ergogenic effect was detected in this group.

  12. Geometry success in 20 mins

    CERN Document Server

    Editors, LearningExpress

    2010-01-01

    Whether you're new to geometry or just looking for a refresher, this completely revised and updated third edition of Geometry Success in 20 Minutes a Day offers a 20-step lesson plan that provides quick and thorough instruction in practical, critical skills. Stripped of unnecessary math jargon but bursting with geometry essentials, Geometry Success in 20 Minutes a Day is an invaluable resource for both students and adults.

  13. Development, preparation and control of sup(99m)Tc or sup(113m)In labelled stannous hydroxide radiopharmaceuticals. Part of a coordinated programme on radiopharmaceuticals

    International Nuclear Information System (INIS)

    The preparation of different sup(99m)Tc and sup(113m)In radiopharmaceuticals using stannous chloride was investigated. Chemical and radiochemical procedures for the quality control of these preparations were studied. Toxicity and biological controls of the preparation were carried out. Procedures for the preparation and control of the following radiopharmaceuticals have been standardized by the authors; albumin macroaggregates labelled with sup(99m)Tc, sup(113m)In and other isotopes for lung scanning; albumin microspheres labelled with sup(99m)Tc for lung scanning; sup(99m)Tc or sup(113m)In-labelled stannous hydroxide colloid for liver scanning; sup(99m)Tc-stannous phytate for liver scanning; sup(99m)Tc-Sn-dextrose, a new radiopharmaceutical which has been proposed by the authors and is now used in Mexico for renal and cerebral scanning and sup(99m)Tc-Sn pyrophosphate and diphosphonate for bone scanning

  14. Analysis of highly nonlinear oscillation systems using He’s max–min method and comparison with homotopy analysis and energy balance methods

    Indian Academy of Sciences (India)

    L B Ibsen; A Barari; A Kimiaeifar

    2010-08-01

    Nonlinear functions are crucial points and terms in engineering problems and the solutions of many important physical problems are centered on finding accurate solutions to these functions. In this paper, a new method called max–min method has been presented for deriving accurate/approximate analytical solution to strong nonlinear oscillators. Furthermore, it is shown that a large class of linear or nonlinear differential equations can be solved without the tangible restriction of sensitivity to the degree of the nonlinear term, adding that the method is quite convenient due to reduction in size of calculations. Results obtained by max–min are compared with Homotopy Analysis Method (HAM), energy balance and numerical solution and it is shown that, simply one term is enough to obtain a highly accurate result in contrast to HAM with just one term in series solution. Finally, the phase plane to show the stability of systems is plotted and discussed.

  15. Flotação aniônica de rejeito de minério de manganês Anionic flotation of tailings of manganese ore

    OpenAIRE

    Rosa Malena Fernandes Lima; João Antônio Vasconcelos; Gláucia Regina da Silva

    2008-01-01

    Normalmente, os fluxogramas brasileiros, tanto para o beneficiamento de minérios ricos, quanto para minérios complexos de manganês, consistem, basicamente, de fragmentação e classificação granulométrica, com o descarte da fração abaixo de 0,106mm. Logo, é muito importante para a indústria mineral desenvolver fluxogramas e processos de concentração dessas frações granulométricas, visando ao aumento da recuperação global de manganês, bem como à redução do impacto ambiental, gerado com o descart...

  16. The Pseudomonas syringae pv. tomato type III effector HopM1 suppresses Arabidopsis defenses independent of suppressing salicylic acid signaling and of targeting AtMIN7.

    Directory of Open Access Journals (Sweden)

    Anju Gangadharan

    Full Text Available Pseudomonas syringae pv tomato strain DC3000 (Pto delivers several effector proteins promoting virulence, including HopM1, into plant cells via type III secretion. HopM1 contributes to full virulence of Pto by inducing degradation of Arabidopsis proteins, including AtMIN7, an ADP ribosylation factor-guanine nucleotide exchange factor. Pseudomonas syringae pv phaseolicola strain NPS3121 (Pph lacks a functional HopM1 and elicits robust defenses in Arabidopsis thaliana, including accumulation of pathogenesis related 1 (PR-1 protein and deposition of callose-containing cell wall fortifications. We have examined the effects of heterologously expressed HopM1Pto on Pph-induced defenses. HopM1 suppresses Pph-induced PR-1 expression, a widely used marker for salicylic acid (SA signaling and systemic acquired resistance. Surprisingly, HopM1 reduces PR-1 expression without affecting SA accumulation and also suppresses the low levels of PR-1 expression apparent in SA-signaling deficient plants. Further, HopM1 enhances the growth of Pto in SA-signaling deficient plants. AtMIN7 contributes to Pph-induced PR-1 expression. However, HopM1 fails to degrade AtMIN7 during Pph infection and suppresses Pph-induced PR-1 expression and callose deposition in wild-type and atmin7 plants. We also show that the HopM1-mediated suppression of PR-1 expression is not observed in plants lacking the TGA transcription factor, TGA3. Our data indicate that HopM1 promotes bacterial virulence independent of suppressing SA-signaling and links TGA3, AtMIN7, and other HopM1 targets to pathways distinct from the canonical SA-signaling pathway contributing to PR-1 expression and callose deposition. Thus, efforts to understand this key effector must consider multiple targets and unexpected outputs of its action.

  17. Monitoring and forecasting of radiation hazard from great solar energetic particle events by using on-line one-min neutron monitor and satellite data

    International Nuclear Information System (INIS)

    The method of automatically determining the start of great solar energetic particle (SEP) events are described on the basis of cosmic ray (CR) one-min observations by neutron monitors in real-time scale. It is shown that the probabilities of false alarms and missed triggers are negligible. After the start of SEP event, it is automatically determined by the method of coupling functions the SEP energy spectrum and flux for each minute of observations. By solving the inverse problem during few first minutes of SEP event, diffusion coefficient in the interplanetary space, source function on the Sun, and time of ejection of SEP into solar wind are determined. For extending obtained results into small energy range we use also available from Internet the satellite one-min CR data. This make possible to give forecast of space-time variation of SEP for more than 2 days and estimate expected radiation dose for satellite and aircraft. With each new minute of observations, the quality of forecast increased, and after ∼30 min became near 100%. (authors)

  18. Pozitif psikoloji yaklaşımıyla mü’min insanın kişilik özellikleri

    OpenAIRE

    CEYLAN, İsa

    2013-01-01

    Ceylan, İsa, Pozitif Psikoloji Yaklaşımıyla Mü’min İnsanın Kişilik Özellikleri, Yüksek Lisans Tezi, Danışman: Prof. Dr. Öznur Özdoğan, Ankara Üniversitesi Sosyal Bilimler Enstitüsü – 2013, 180 s. Bu çalışmada İslam terminolojisinde tanımlanan “mü’min”in kişilik özelliklerini araştırdık. “Mü’min insan kişiliği” araştırılırken Pozitif Psikoloji bakış açısından yararlandık. Mü’min insanın; her şeyin güzel taraflarını gören, hayata pozitif bakan, her an insanlara ve Allah’a güven veren v...

  19. The Search for Maximal Values of min(A,B,C) / gcd(A,B,C) for A^x + B^y = C^z

    CERN Document Server

    Townsend, Arthur R

    2010-01-01

    This paper answers a question asked by Ed Pegg Jr. in 2001: "What is the maximal value of min(A,B,C)/ gcd(A,B,C) for A^x + B^y = C^z with A,B,C >= 1; x,y,z >= 3?" Equations of this form are analyzed, showing how they map to exponential Diophantine equations with coprime bases. A search algorithm is provided to find the largest min/gcd value within a given equation range. The algorithm precalculates a multi-gigabyte lookup table of power residue information that is used to eliminate over 99% of inputs with a single array lookup and without any further calculations. On inputs that pass this test, the algorithm then performs further power residue tests, avoiding modular powering by using lookups into precalculated tables, and avoiding division by using multiplicative inverses. This algorithm is used to show the largest min/gcd value for all equations with C^z <= 2^100.

  20. A Prediction Method for△f0F2min of a Single Station From Interplanetary Parameters Based on Statistical Study

    Institute of Scientific and Technical Information of China (English)

    LI Zheng; WEI Fengsi; FENG Xueshang; GUO Jianpeng; XU Xiaojun

    2012-01-01

    Using 86 CME-interplanetary shock events,the correlation between the peak values of (a) the solar wind parameters(Bz,Ey,Pdyn) and the geomagnetic indices(SYM-H,ASY-H,Kp), (b) the coupling functions(Borovsky,Akasofu,Newell) and the geomagnetic indices,(c) the solar wind parameters/coupling functions/geomagnetic indices and the ionospheric parameter(△f0F2min), are investigated.The statistical results show that in group(a),Bz min and SYM-Hmin have the best correlation,that in group(b),the best correlation is between the peak values of Akasofu function (Amin) and SYM-Hmin,and that in group(c),the best correlation is between (pmax and △f0F2min). Based on the statistical results,a method for predicting f0F2 of a single station is attempted to be set up.The input is modified B_(z min) and the outputs are SYM-Hmin and △f0F2min.Then 25 CME-IPS events that caused geomagnetic storms in 1998 and 2009 are used to check the prediction method. The results show that our method can be used to predict SYM-Hmin and △f0F2min

  1. Proteomic screening of glucose-responsive and glucose non-reponsive MIN-6 beta cells reveals differential expression of protein involved in protein folding, secretion and oxidative stress

    DEFF Research Database (Denmark)

    Dowling, P.; O´Driscoll, L.; O´Sullivan, F.;

    2006-01-01

    The glucose-sensitive insulin-secretion (GSIS) phenotype is relatively unstable in long-term culture of beta cells. The purpose of this study was to investigate relative changes in the proteome between glucose-responsive (low passage) and glucose non-responsive (high passage) murine MIN-6...... pancreatic beta cells. The 2D-DIGE and subsequent DeCyder analysis detected 3351 protein spots in the pH range of 4-7. Comparing MIN-6(H) to MIN-6(L) and using a threshold of 1.2-fold, the number of proteins with a decrease in expression level was 152 (4.5%), similar was 3140 (93.7%) and increased 59 (1.......8%). From the differentially expressed proteins identified in this study, groups of proteins associated with the endoplasmic reticulum (ER) and proteins involved in oxidative stress were found to be significantly decreased in the high-passage (H passage) cells. These proteins included endoplasmic reticulum...

  2. 郑敏早期诗歌的多重艺术来源%Multiple Art Origins of the Early Poetry by Zheng Min

    Institute of Scientific and Technical Information of China (English)

    邱景华

    2015-01-01

    Zheng Min's poetry was greatly influenced by Feng Zhi (1 905 - 1 993 )and Rainer Maria Rilke (1875 -1 926),which made two of the poets the main but not all art origins for Zheng Min's poetic creation in her later period. Before the above-mentioned two poets,the art origins of Zheng Min's early poetry were rooted in four aspects,thus forming her early three periods in poetic creation.%郑敏诗歌创作的艺术来源虽然深受冯至和里尔克的影响,但这只是她诗歌创作的主要艺术来源,而不是全部来源,并且是在其后期诗歌创作中;在这之前,影响郑敏早期诗歌的有四个艺术来源,从而形成她早期诗歌的三个阶段。

  3. Transcription of TIR1-Controlled Genes Can be Regulated within 10 Min by an Auxin-Induced Process. Can TIR1 be the Receptor?

    Science.gov (United States)

    Labusch, Corinna; Effendi, Yunus; Fulda, Martin; Scherer, Günther F E

    2016-01-01

    ABP1 and TIR1/AFBs are known as auxin receptors. ABP1 is linked to auxin responses several of which are faster than 10 min. TIR1 regulates auxin-induced transcription of early auxin genes also within minutes. We use transcription of such TIR1-dependent genes as indicator of TIR1 activity to show the rapid regulation of TIR1 by exogenous auxin. To this end, we used quantification of transcription of a set of fifteen early auxin-induced reporter genes at t = 10 and t = 30 min to measure this as a TIR1-dependent auxin response. We conducted this study in 22 mutants of auxin transporters (pin5, abcb1, abcb19, and aux1/lax3), protein kinases and phosphatases (ibr5, npr1, cpk3, CPK3-OX, d6pk1, d6pkl1-1, d6pkl3-2, d6pkl1-1/d6pkl2-2, and d6pkl1-1/d6pkl3-2), of fatty acid metabolism (fad2-1, fad6-1, ssi2, lacs4, lacs9, and lacs4/lacs9) and receptors (tir1, tir1/afb2, and tir1/afb3) and compared them to the wild type. After 10 min auxin application, in 18 out of 22 mutants mis-regulated expression of at least one reporter was found, and in 15 mutants transcription of two-to-three out of five selected auxin reporter genes was mis-regulated. After 30 min of auxin application to mutant plants, mis-regulation of reporter genes ranged from one to 13 out of 15 tested reporter genes. Those genes chosen as mutants were themselves not regulated in their expression by auxin for at least 1 h, excluding an influence of TIR1/AFBs on their transcription. The expression of TIR1/AFB genes was also not modulated by auxin for up to 3 h. Together, this excludes a feedback or feedforward of these mutant genes/proteins on TIR1/AFBs output of transcription in this auxin-induced response. However, an auxin-induced response needed an as yet unknown auxin receptor. We suggest that the auxin receptor necessary for the fast auxin-induced transcription modulation could be, instead, ABP1. The alternative hypothesis would be that auxin-induced expression of a protein, initiated by TIR1/AFBs receptors

  4. A Northern contaminant mixture impairs pancreas function in obese and lean JCR rats and inhibits insulin secretion in MIN6 cells.

    Science.gov (United States)

    Mailloux, Ryan; Fu, Accalia; Florian, Maria; Petrov, Ivan; Chen, Qixuan; Coughlan, Melanie C; Laziyan, Mahemuti; Yan, Jin; Caldwell, Don; Patry, Dominique; Lalande, Michelle; Wang, Gen-Sheng; Willmore, William; Jin, Xiaolei

    2015-08-01

    Rates of obesity and diabetes mellitus of Arctic populations are increasing due to multiple reasons including a departure from traditional lifestyles and alcohol consumption patterns. These populations are also exposed to a variety of anthropogenic contaminants through consumption of contaminated country foods. We have previously shown that a Northern contaminant mixture (NCM), containing 22 organic and inorganic contaminants found in the blood of Canadian Arctic populations, induces endothelial cell dysfunction and exacerbates development of non-alcoholic fatty liver disease in experimental models. In order to determine if these contaminants affect pancreas function and physiology and if obesity and alcohol can influence contaminant toxicity and the development of diabetes, lean and obese JCR rats were orally treated with NCM at 0 (vehicle), 1.6 or 16mg/kg BW for four weeks in the presence or absence of 10% (v/v) alcohol. NCM treatment altered islet morphology, increased iron deposit in pancreas, and reduced circulating and pancreatic insulin levels and circulating glucagon levels as a result of direct islet injury with β and α cell loss with or without exposure to alcohol. Studies conducted with cultured mouse insulin-secreting (MIN6) β cells further demonstrated that NCM inhibited insulin release and induced cell death through oxidative stress and mitochondrial dysfunction. 2,3,4,6-Tetrabromophenol, a minor component of the NCM, alone also inhibited insulin release from MIN6 cells after 10min of exposure. These results suggest that Northern contaminants may contribute to pancreatic dysfunction, and possibly development of diabetes, in some of the highly exposed Arctic populations. The implications and relevance of these findings to Northern populations remains to be confirmed through epidemiological studies.

  5. Reproducibility of automated simplified voxel-based analysis of PET amyloid ligand [{sup 11}C]PIB uptake using 30-min scanning data

    Energy Technology Data Exchange (ETDEWEB)

    Aalto, Sargo [University of Turku and Turku University Hospital, Turku PET Centre, Turku (Finland); Aabo Akademi University, Department of Psychology, Turku (Finland); University of Turku, Turku PET Centre, P.O. Box 52, Turku (Finland); Scheinin, Noora M.; Naagren, Kjell; Rinne, Juha O. [University of Turku and Turku University Hospital, Turku PET Centre, Turku (Finland); Kemppainen, Nina M. [University of Turku and Turku University Hospital, Turku PET Centre, Turku (Finland); Turku University Hospital, Department of Neurology, Turku (Finland); Kailajaervi, Marita [University of Turku, Department of Pharmacology and Clinical Research Services Turku (CRST), Turku (Finland); GE Healthcare, Turku Imanet, Turku (Finland); Leinonen, Mika [4-Pharma Ltd, Turku (Finland); Scheinin, Mika [University of Turku, Department of Pharmacology and Clinical Research Services Turku (CRST), Turku (Finland)

    2009-10-15

    Positron emission tomography (PET) with {sup 11}C-labelled Pittsburgh compound B ([{sup 11}C]PIB) enables the quantitation of {beta}-amyloid accumulation in the brain of patients with Alzheimer's disease (AD). Voxel-based image analysis techniques conducted in a standard brain space provide an objective, rapid and fully automated method to analyze [{sup 11}C]PIB PET data. The purpose of this study was to evaluate both region- and voxel-level reproducibility of automated and simplified [{sup 11}C]PIB quantitation when using only 30 min of imaging data. Six AD patients and four healthy controls were scanned twice with an average interval of 6 weeks. To evaluate the feasibility of short scanning (convenient for AD patients), [{sup 11}C]PIB uptake was quantitated using 30 min of imaging data (60 to 90 min after tracer injection) for region-to-cerebellum ratio calculations. To evaluate the reproducibility, a test-retest design was used to derive absolute variability (VAR) estimates and intraclass correlation coefficients at both region-of-interest (ROI) and voxel level. The reproducibility both at the region level (VAR 0.9-5.5%) and at the voxel level (VAR 4.2-6.4%) was good to excellent. Based on the variability estimates obtained, power calculations indicated that 90% power to obtain statistically significant difference can be achieved using a sample size of five subjects per group when a 15% change from baseline (increase or decrease) in [{sup 11}C]PIB accumulation in the frontal cortex is anticipated in one group compared to no change in another group. Our results showed that an automated analysis method based on an efficient scanning protocol provides reproducible results for [{sup 11}C]PIB uptake and appears suitable for PET studies aiming at the quantitation of amyloid accumulation in the brain of AD patients for the evaluation of progression and treatment effects. (orig.)

  6. Ostokäyttäytymisen tutkiminen ja segmentointi yhdistysasiakkaille suunnattujen kulttuurimatkailupakettien kehittämiseksi - case Ahlströmin ruukit

    OpenAIRE

    Mäkinen, Siri

    2015-01-01

    Tämän opinnäytetyön tarkoituksena oli tutkia kotimaan kulttuuripalveluita hyödyntävien yhdistysasiakkaiden ostokäyttäytymistä ja ostopäätökseen vaikuttavia asioita. Tulosten pohjalta oli tarkoitus luoda asiakkaista segmenttejä ja antaa toimeksiantajalle kulttuurimatkailupaketteja koskevia kehitysehdotuksia. Tämä opinnäytetyö tehtiin toimeksiantona Ahlströmin ruukkien palveluliiketoiminnalle. Opinnäytetyön teoriaosuudessa selvennettiin lukijalle kulttuurimatkailun ja matkailutuotteen käsi...

  7. Les consommations d'énergie dans l'industrie minérale (résumé Energy Consumption in the Mineral Industry (Summary

    Directory of Open Access Journals (Sweden)

    Gentilhomme P. H.

    2006-11-01

    Full Text Available Dans le cadre limité de cette présentation, il était préférable de placer l'accent, non sur les évaluations du coût énergétique des diverses substances minérales, mais plutôt sur les paramètres de ces coûts, leur évolution récente et leur devenir dans une prospective à moyen terme, questions susceptibles d'alimenter ensuite les discussions. Après un bref rappel méthodologique, seront successivement examinés : - d'un point de vue global, la consommation d'énergie de l'industrie minérale, sa répartition et son évolution par formes d'énergie mises en oeuvre ; - d'un point de vue analytique, la nature des facteurs qui régissent les coûts énergétiques miniers, minéralurgiques et métallurgiques, les tendances récentes constatées et leurs implications pour l'avenir ; - d'un point de vue prospectif, enfin, quelques-uns des remèdes - ou palliatifs ? - à l'élévation des coûts énergétiques des substances minérales. Within the required time for the presentation of this paper, it was more advisable to emphasize, not the sizing up of the energy cost of mineral raw materials and products, but rather the parameters of thes costs, and their evolution, actual and in a medium-term prospective, questions of eventual interest for the discussions. After a short recall of methodology, we have to examine successively: - on a global standpoint, the energy consumption of the mineral industry, the breakdown of this consumption by forms of energy used, and its evolution; - on an analytical standpoint, the main factors which direct the energy requirements in mining, beneficiating and smeltinq operations, the trends that are observed and their results for the future; - on a prospective standpoint, at last, what are the possibilities to cut off - or palliate? - the increase of the mineral commodities energy costs.

  8. A Study on the First Issue Date ofMin Sheng Daily in Nanjing%南京《民生报》发刊日考

    Institute of Scientific and Technical Information of China (English)

    黄志辉

    2012-01-01

    目前文献中关于南京《民生报》何时发刊可说是众说纷纭,莫衷一是,本文就此问题略作探究,辨析已有的几种代表性说法,分析考证相关文献,以辩证出正确的发刊日。%When Min Sheng Daily in Nanjing first issued remains as a dispute, This paper analyzes the representative opinions on this question, and tries to find out the first issue date through the relevant documents.

  9. "PolyMin": software for identification of the minimum number of polymorphisms required for haplotype and genotype differentiation

    DEFF Research Database (Denmark)

    Frei, Ursala K; Wollenweber, Bernd; Lübberstedt, Thomas

    2009-01-01

    . To date, software for identification of the minimum number of required markers has been optimized for human genetics and is only partly matching the needs of plant scientists and breeders. In addition, different software packages with insufficient interoperability need to be combined to extract...... this information from available allele sequence data, resulting in an errorprone multi-step process of data handling. Results: PolyMin, a computer program combining the detection of a minimum set of single nucleotide polymorphisms (SNPs) and/or insertions/deletions (INDELs) necessary for allele differentiation...

  10. GrafoMin: una herramienta para el aprendizaje y la construcción del camino más corto entre dos nodos de un grafo

    OpenAIRE

    Iglesias Bello, Gustavo Adolfo

    2012-01-01

    GrafoMin es el nombre de una herramienta gráfica para el aprendizaje y la construcción del camino más corto entre dos nodos (o vértices) de un grafo. Esta herramienta puede ser utilizada tanto por los estudiantes, en el proceso de aprendizaje usando el algoritmo de Dijsktra y como prueba de auto-evaluación, así como por los profesores que deseen impartir dicha materia. El usuario puede crear el grafo a su gusto: añadiendo tantos vértices y aristas como desee, indicando los vértices inicial y ...

  11. Caracterização de minérios: uso do Magstream-Model 100, suas vantagens e limitações

    Directory of Open Access Journals (Sweden)

    Maria José Gazzi Salum

    2002-03-01

    Full Text Available O presente trabalho discute a importância da caracterização de minérios como suporte para o entendimento do comportamento de seus minerais frente a processos de tratamento de minérios, controle de processos e controle da qualidade dos produtos obtidos. É, também, apresentada uma breve revisão da literatura sobre as principais técnicas de caracterização, incluindo aquelas utilizadas para a separação de minerais de um minério. Especial atenção foi dada à técnica de separação de minerais de um minério, utilizando um equipamento chamado Magstream-Model 100. O trabalho mostra que o processo Magstream, que envolve o uso de fluido magnético como meio separador, campo magnético e um sistema de rotação, oferece vantagens em relação a outras técnicas, como, por exemplo, a de líquidos densos. Entretanto o processo utilizado pelo Magstream leva a mudanças em propriedades de superfície dos minerais, modificando seus comportamentos frente à flotação. Esse fato foi considerado como uma limitação de seu uso, quando estudos posteriores com os minerais processados no Magstream envolvem propriedades de superfície.This paper discusses the importance of mineral characterization as a support to understand their behavior in mineral processing and in the control of the processes and quality of the products obtained. Also presented is a brief review on the main techniques used in minerals characterization, including the procedures for minerals separation from an ore. Special attention was given to the technique of mineral separation from an ore according to their specific gravities using a device called Magstream-Model 100. It is shown that the Magstream process, which involves the use of a magnetic fluid as a medium for mineral separation, a magnetic field and a rotation speed system, offers advantages compared to the heavy liquids technique. However, the Magstream process leads to changes on mineral surface properties, imparting to

  12. Generator 113Sn-sup(113m)In. Study of the most important characteristics in the eluate composition for the preparation of clinical labelled compounds

    International Nuclear Information System (INIS)

    The design for the construction of a generator 113Sn-sup(113m)In is described. A systematic assay for the adequate adsorbents has been made, to obtain solutions of high radiochemical purity, as it is required for the radiopharmaceutical preparations. The control of purity is carried on by qualitative and quantitative analysis of the solutions, complemented by radiochemical techniques. The following physico-chemical parameters have been determinated; consecutive equilibrium constants, pH, distribution constants, separation factors and electrophoretic factors. It has been considered the measure of these parameters for the best quality in the preparation of the radiopharmaceutical compounds. (author)

  13. Comparative Analyses between Skeletal Muscle miRNAomes from Large White and Min Pigs Revealed MicroRNAs Associated with Postnatal Muscle Hypertrophy

    OpenAIRE

    Sheng, Xihui; Wang, Ligang; Ni, Hemin; Wang, Lixian; Qi, Xiaolong; Xing, Shuhan; Guo, Yong

    2016-01-01

    The molecular mechanism regulated by microRNAs (miRNAs) that underlies postnatal hypertrophy of skeletal muscle is complex and remains unclear. Here, the miRNAomes of longissimus dorsi muscle collected at five postnatal stages (60, 120, 150, 180, and 210 days after birth) from Large White (commercial breed) and Min pigs (indigenous breed of China) were analyzed by Illumina sequencing. We identified 734 miRNAs comprising 308 annotated miRNAs and 426 novel miRNAs, of which 307 could be consider...

  14. Ihana kehittyvä minä - Matkalla tytöstä naiseksi : voimavaralähtöistä seksuaaliterveysneuvontaa kuudesluokkalaisille tytöille

    OpenAIRE

    Nieminen, Katariina; Lindholm, Susanna

    2012-01-01

    Nieminen, Katariina & Lindholm, Susanna. Ihana kehittyvä minä – Matkalla tytöstä naiseksi. Voimavaralähtöistä seksuaaliterveysneuvontaa kuudesluokkalaisille tytöille. Diak Etelä, Helsinki, kevät 2012, 73 s., 6 liitettä. Diakonia-ammattikorkeakoulu, Hoitotyön koulutusohjelma, terveydenhoitaja (AMK) ja sairaanhoitaja (AMK). Opinnäytetyön tarkoituksena oli arvioida kuudesluokkalaisten tyttöjen tarvetta opetuksesta erilliselle seksuaaliterveysneuvonnalle ja kehittää voimavaralähtöinen ...

  15. Atomic Force Microscopy Characterization of Protein Fibrils Formed by the Amyloidogenic Region of the Bacterial Protein MinE on Mica and a Supported Lipid Bilayer.

    Directory of Open Access Journals (Sweden)

    Ya-Ling Chiang

    Full Text Available Amyloid fibrils play a crucial role in many human diseases and are found to function in a range of physiological processes from bacteria to human. They have also been gaining importance in nanotechnology applications. Understanding the mechanisms behind amyloid formation can help develop strategies towards the prevention of fibrillation processes or create new technological applications. It is thus essential to observe the structures of amyloids and their self-assembly processes at the nanometer-scale resolution under physiological conditions. In this work, we used highly force-sensitive frequency-modulation atomic force microscopy (FM-AFM to characterize the fibril structures formed by the N-terminal domain of a bacterial division protein MinE in solution. The approach enables us to investigate the fibril morphology and protofibril organization over time progression and in response to changes in ionic strength, molecular crowding, and upon association with different substrate surfaces. In addition to comparison of the fibril structure and behavior of MinE1-31 under varying conditions, the study also broadens our understanding of the versatile behavior of amyloid-substrate surface interactions.

  16. Inhibitory effect of procaterol on exercise dynamic lung hyperinflation during the 6-min walk test in stable patients with chronic obstructive pulmonary disease.

    Science.gov (United States)

    Satake, Masahiro; Takahashi, Hitomi; Sugawara, Keiyu; Kawagoshi, Atsuoshi; Tamaki, Akira; Homma, Mitsunobu; Morita, Ryou; Sato, Kazuhiro; Sano, Masaaki; Shioya, Takanobu

    2011-01-01

    The purpose of this study was to evaluate the inhibitory effect of procaterol (procaterol hydrochloride, CAS 62929-91-3) on exercise dynamic lung hyperinflation during the 6-min walk test (6MWT) in stable chronic obstructive disease (COPD) patients. Fourteen patients with stable COPD who were referred to our clinic between July 2008 and October 2009 were evaluated in this study. After the inhalation of procaterol, values for the lung function test, including vital capacity, inspiratory capacity, forced vital capacity, and FEV1/FEV1pred showed a significant improvement. Compared to the baseline assessment, the 6-min walk distance increased by a mean of 20.5 m when measured after inhalation of procaterol (512.4 +/- 90.7 m vs. 532.9 +/- 79.8 m, p lung hyperinflation, suggesting the important role of the beta2-receptor agonist procaterol in the treatment of COPD. It is therefore likely that most patients with COPD may derive considerable benefit from bronchodilator therapy with procaterol.

  17. BioMinE:An integrated project for developing biohydrometallurgy in Europe—Executive summary of its activities and outputs after three years

    Institute of Scientific and Technical Information of China (English)

    Dominique H.R.MORIN

    2008-01-01

    Biohydrometallurgy is the offspring of the unexpected union of biotechnology and metallurgy.From specific properties of some extreme biotopes,active principles of interactions between microbial metabolisms and minerals have been extracted to be used as efficient metallurgical processes.Many profitable industrial operations based on these bioprocesses have been running to recover copper,gold,uranium or cobalt for instance and many other applications have been designed.Europe was quite active in this area in the past,but currently the leadership is in South Africa,America and Australia.BioMinE (Biotechnology of Metal-bearing material In Europe) is a large integrated project launched with the support of the European Commision.It is aimed at stimulating synergies between the most relevant universities,research and industrial organizations to develop new concepts in this technical field that allow a better exploitation of the mineral resources in the future.The European non-ferrous metals mining industry has initiated and developed the BioMinE project as they identified the need to find new processes for metal extraction from resources of today and of tomorrow.

  18. Post-translational glycoprotein modifications regulate colon cancer stem cells and colon adenoma progression in Apc(min/+) mice through altered Wnt receptor signaling.

    Science.gov (United States)

    Guo, Huabei; Nagy, Tamas; Pierce, Michael

    2014-11-01

    Deletion of GnT-V (MGAT5), which synthesizes N-glycans with β(1,6)-branched glycans, reduced the compartment of cancer stem cells (CSC) in the her-2 mouse model of breast cancer, leading to delay of tumor onset. Because GnT-V levels are also commonly up-regulated in colon cancer, we investigated their regulation of colon CSC and adenoma development. Anchorage-independent cell growth and tumor formation induced by injection of colon tumor cells into NOD/SCID mice were positively associated with GnT-V levels, indicating regulation of proliferation and tumorigenicity. Using Apc(min/+) mice with different GnT-V backgrounds, knock-out of GnT-V had no significant effect on the number of adenoma/mouse, but adenoma size was significantly reduced and accompanied increased survival of Apc(min/+) mice with GnT-V deletion (p cells, we found that FZD-7 receptors expressed N-linked β(1,6) branching, indicating that FZD-7 can be modified by GnT-V. The aberrant Wnt signaling observed after modulating GnT-V levels is likely to result from altered N-linked β(1,6) branching on FZD-7, thereby affecting Wnt signaling, the compartment of CSC, and tumor progression.

  19. The Intrauterine and Nursing Period Is a Window of Susceptibility for Development of Obesity and Intestinal Tumorigenesis by a High Fat Diet in Min/+ Mice as Adults

    Directory of Open Access Journals (Sweden)

    Ha Thi Ngo

    2015-01-01

    Full Text Available We studied how obesogenic conditions during various life periods affected obesity and intestinal tumorigenesis in adult C57BL/6J-Min (multiple intestinal neoplasia/+ mice. The mice were given a 10% fat diet throughout life (negative control or a 45% fat diet in utero, during nursing, during both in utero and nursing, during adult life, or during their whole life-span, and terminated at 11 weeks for tumorigenesis (Min/+ or 23 weeks for obesogenic effect (wild-type. Body weight at 11 weeks was increased after a 45% fat diet during nursing, during both in utero and nursing, and throughout life, but had normalized at 23 weeks. In the glucose tolerance test, the early exposure to a 45% fat diet in utero, during nursing, or during both in utero and nursing, did not affect blood glucose, whereas a 45% fat diet given to adults or throughout life did. However, a 45% fat diet during nursing or during in utero and nursing increased the number of small intestinal tumors. So did exposures to a 45% fat diet in adult life or throughout life, but without increasing the tumor numbers further. The intrauterine and nursing period is a window of susceptibility for dietary fat-induced obesity and intestinal tumor development.

  20. One-step kinetics-based immunoassay for the highly sensitive detection of C-reactive protein in less than 30 min.

    Science.gov (United States)

    Vashist, Sandeep Kumar; Czilwik, Gregor; van Oordt, Thomas; von Stetten, Felix; Zengerle, Roland; Marion Schneider, E; Luong, John H T

    2014-07-01

    This article reveals a rapid sandwich enzyme-linked immunosorbent assay (ELISA) for the highly sensitive detection of human C-reactive protein (CRP) in less than 30 min. It employs a one-step kinetics-based highly simplified and cost-effective sandwich ELISA procedure with minimal process steps. The procedure involves the formation of a sandwich immune complex on capture anti-human CRP antibody-bound Dynabeads in 15 min, followed by two magnet-assisted washings and one enzymatic reaction. The developed sandwich ELISA detects CRP in the dynamic range of 0.3 to 81 ng ml(-1) with a limit of detection of 0.4 ng ml(-1) and an analytical sensitivity of 0.7 ng ml(-1). It detects CRP spiked in diluted human whole blood and serum with high analytical precision, as confirmed by conventional sandwich ELISA. Moreover, the results of the developed ELISA for the determination of CRP in the ethylenediaminetetraacetic acid plasma samples of patients are in good agreement with those obtained by the conventional ELISA. The developed immunoassay has immense potential for the development of rapid and cost-effective in vitro diagnostic kits.

  1. Survival of mouse oocytes after being cooled in a vitrification solution to -196°C at 95° to 70,000°C/min and warmed at 610° to 118,000°C/min: A new paradigm for cryopreservation by vitrification.

    Science.gov (United States)

    Mazur, Peter; Seki, Shinsuke

    2011-02-01

    There is great interest in achieving reproducibly high survivals of mammalian oocytes (especially human) after cryopreservation, but the results to date have not matched the interest. A prime cause of cell death is the formation of more than trace amounts of intracellular ice, and one strategy to avoid it is vitrification. In vitrification procedures, cells are loaded with high concentrations of glass-inducing solutes and cooled to -196°C at rates high enough to presumably induce the glassy state. In the last decade, several devices have been developed to achieve very high cooling rates. Nearly all in the field have assumed that the cooling rate is the critical factor. The purpose of our study was to test that assumption by examining the consequences of cooling mouse oocytes in a vitrification solution at four rates ranging from 95 to 69,250°C/min to -196°C and for each cooling rate, subjecting them to five warming rates back above 0°C at rates ranging from 610 to 118,000°C/min. In samples warmed at the highest rate (118,000°C/min), survivals were 70% to 85% regardless of the prior cooling rate. In samples warmed at the lowest rate (610°C/min), survivals were low regardless of the prior cooling rate, but decreased from 25% to 0% as the cooling rate was increased from 95 to 69,000°C/min. Intermediate cooling and warming rates gave intermediate survivals. The especially high sensitivity of survival to warming rate suggests that either the crystallization of intracellular glass during warming or the growth by recrystallization of small intracellular ice crystals formed during cooling are responsible for the lethality of slow warming.

  2. Flotação aniônica de rejeito de minério de manganês Anionic flotation of tailings of manganese ore

    Directory of Open Access Journals (Sweden)

    Rosa Malena Fernandes Lima

    2008-09-01

    Full Text Available Normalmente, os fluxogramas brasileiros, tanto para o beneficiamento de minérios ricos, quanto para minérios complexos de manganês, consistem, basicamente, de fragmentação e classificação granulométrica, com o descarte da fração abaixo de 0,106mm. Logo, é muito importante para a indústria mineral desenvolver fluxogramas e processos de concentração dessas frações granulométricas, visando ao aumento da recuperação global de manganês, bem como à redução do impacto ambiental, gerado com o descarte desses finos. Nesse trabalho, são apresentados estudos comparativos de flotação aniônica de um rejeito de minério complexo sílico-carbonatado, constituído, principalmente, pelos minerais rodocrosita, rodonita, espessartia clinocloro, quartzo, anita e flogopita, usando os coletores oleato de sódio e sabão de óleo de soja com o depressor silicato de sódio. Através desses estudos, foram verificadas reduções dos teores de SiO2 da alimentação (28,10% de cerca de 11 e 8% para o oleato de sódio e o sabão de óleo de soja, respectivamente em pH 11.The Brazilian processing flowsheet that is used to concentrate both the rich and complex manganese ores is constituted by size reduction and size classification. The particles with size below 0.106mm normally are discharged as waste. So it is very important for the mineral industry to develop flowsheets and processes in order to improve the global manganese recovery and to reduce the environmental impact with these wastes that are deposited on the land. In this work is presented an anionic froth flotation comparative study between two different anionic collectors (sodium oleate and soybean oil soap and sodium silicate depressant to concentrate the silicate-carbonated manganese ore waste that was constituted mainly by rodocrosite, rodonite, espessartite, clinoclore, quartz, annite and flogopite minerals. It was observed that at pH 11 the SiO2 content in the feed (28.1% was reduced

  3. Avaliação econômica do minério remanescente nos taludes da cava final da Mina de Alegria

    Directory of Open Access Journals (Sweden)

    Adilson Curi

    2003-03-01

    Full Text Available Esse trabalho apresenta uma estimativa do benefício que pode ser auferido através da recuperação do minério remanescente nos taludes da cava final de uma mina a céu aberto através da aplicação de uma metodologia de lavra baseada no método de corte e enchimento. Para exemplificar o uso da metodologia proposta, foi adotado o caso das minas de minério de ferro de Alegria de propriedade da Samarco Mineração S.A. A viabilidade econômica da recuperação do minério remanescente em taludes de cavas exauridas de minas a céu aberto envolve recursos que estarão diretamente ligadas ao valor de mercado do produto e ao custo operacional para sua recuperação. Na fase de exaustão de uma mina, tradicionalmente, considerada como de desembolso de capital, a geração de receitas adicionais é bem-vinda, pois implica ganhos econômicos não previstos na fase de fechamento de minas e até em minas já paralisadas, acrescendo-se também um ganho ambiental devido à não construção de pilhas de estéril.This paper introduces estimated benefits, obtainable by use of "cut and filling" mine-methodology extraction of ore remaining in slopes of the final pit in an open pit mining operation. The economic viability of this method considers product market value and operational costs. When terminating a mining operation, the generation of additional revenue is highly desired, since it implies unforeseen economical earnings. This also holds true for already-closed mines. When the method desribed in this study is used, there is also an environmental bonus since there is no waste pile construction.

  4. A study of gravity-wave spectra in the troposphere and stratosphere at 5-min to 5-day periods with the Poker Flat MST radar

    Science.gov (United States)

    Bemra, R. S.; Rastogi, P. K.; Balsley, B. B.

    1986-01-01

    An analysis of frequency spectra at periods of about 5 days to 5 min from two 20-day sets of velocity measurements in the stratosphere and troposphere region obtained with the Poker Flat mesosphere-stratosphere-troposphere (MST) radar during January and June, 1984 is presented. A technique based on median filtering and averaged order statistics for automatic editing, smoothing and spectral analysis of velocity time series contaminated with spurious data points or outliers is outlined. The validity of this technique and its effects on the inferred spectral index was tested through simulation. Spectra obtained with this technique are discussed. The measured spectral indices show variability with season and height, especially across the tropopause. The discussion briefly outlines the need for obtaining better climatologies of velocity spectra and for the refinements of the existing theories to explain their behavior.

  5. Caracterização tecnológica de rejeito de minério de ferro Technological characterization of iron ore tailing

    OpenAIRE

    Marcos Antônio Gomes; Carlos Alberto Pereira; Antônio Eduardo Clark Peres

    2011-01-01

    Nesse trabalho, é apresentada a caracterização dos finos, estocados na barragem I como rejeito proveniente do tratamento de minério ferro. Na caracterização das amostras, estão apresentadas análises granulométricas por peneiramento a úmido, análises químicas por espectrometria de plasma e análise mineralógica por difração de raios X. De posse das análises de caracterização, foram executados ensaios tecnológicos, visando à obtenção de concentrado para aplicação na indústria metalúrgica. Foram ...

  6. WEN Jian-min and SHI Da-zhuo : ICWM Should Be Taken as A Discipline Uniformly and The Practice Scope of ICWM Practitioners Be Defined

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    @@ According to the current inconsistent status of subject names and stratification of ICWM and based on the principle of classification that a subject can only use one name and one code, Prof. WEN Jian-min and Prof. SHI Da-zhuo, two CPPCC members, proposed that ICWM in the subject categories of National Standardization Committee (defined as a subdiscipline under CM and Chinese materia medica) and that in the subject categories of the Academic Degree Commission of the State Council (defined as a discipline, consisting of two sub-disciplines, the basic ICWM and the clinical ICWM) should be taken as a discipline uniformly, consisting of 12 subdisciplines, Basic Medicine, Clinical Medicine, Diagnostics, Internal Medicine, Surgery, Orthopaedics, Pediatrics,Ophthalmology, Otorhinolaryngology, Dermatology and Venereology, Obstetrics and Gynecology, and Other Subjects.

  7. Applications of a saving method with max-min ant system to a vehicle routing problem with time windows and speed limits

    Directory of Open Access Journals (Sweden)

    Suphan Sodsoon

    2014-06-01

    Full Text Available This study aims to solve a Vehicle Routing Problem with Time Windows and Speed Limits (VRPTWSL, which has received considerable attention in recent years. The vehicle routing problem with time windows is an extension of the well-known Vehicle Routing Problem (VRP and involves a fleet of vehicles set of from a depot to serve a number of customers at different geographic locations with various demands within specific time and speed limits before returning to the depot eventually. To solve the problem, an efficient Saving Method-Max Min Ant System (Saving-MMAS with Local Search algorithm is applied. Using minimization of the total transportation costs as the objective of the extension VRPTWSL, a mathematic model is constructed. Finally, the Saving-MMAS algorithms indicated the good quality of the method in this problem.

  8. Détermination de la compacité des ciments et additions minérales à la sonde de Vicat

    OpenAIRE

    Sedran, Thierry; De Larrard, François; Le Guen, Laurédan

    2007-01-01

    La méthode scientifique de formulation des bétons, développée par le LCPC et mise en oeuvre dans le logiciel BétonlabPro depuis plusieurs années, est fondée sur des concepts granulaires. C'est pourquoi l'utilisation de ce logiciel nécessite la connaissance de la compacité de l'ensemble des fractions granulaires élémentaires, et notamment celle des poudres minérales (ciments, additions etc.). Pour ces dernières, une mesure visuelle de la demande en eau, par recherche d'un changement d'état ent...

  9. 济南市闵子骞祠堂东汉墓%Eastern Han Tomb in the Min Ziqian Ancestral Temple in Jinan City

    Institute of Scientific and Technical Information of China (English)

    济南市考古研究所

    2004-01-01

    In 2000, the Jinan Municipal Institute of Archaeology carried out a rescuing excavation to explore a tomb in the Min Ziqian ancestral temple, Jinan City. The grave is built of brick and stone, consists of an anterior, a middle, a back and two side rooms, and has a "凸"-shaped plan. It has been seriously robbed, but still above 60 pottery objects and copper coins are left over from the grave goods. Among them pottery domestic fowls and animals come first in number, and four pictorial stones remain in the tomb. The tomb shape, the features of the objects and those of the pictorial stones suggest that the burial belongs to the late Eastern Han period.

  10. Elevated incidence of polyp formation in APC(Min/⁺Msh2⁻/⁻ mice is independent of nitric oxide-induced DNA mutations.

    Directory of Open Access Journals (Sweden)

    Antoaneta Belcheva

    Full Text Available Gut microbiota has been linked to a number of human diseases including colon cancer. However, the mechanism through which gut bacteria influence colon cancer development and progression remains unclear. Perturbation of the homeostasis between the host immune system and microbiota leads to inflammation and activation of macrophages which produce large amounts of nitric oxide that acts as a genotoxic effector molecule to suppress bacterial growth. However, nitric oxide also has genotoxic effects to host cells by producing mutations that can predispose to colon cancer development. The major DNA lesions caused by nitric oxide are 8oxoG and deamination of deoxycytosine bases. Cellular glycosylases that belong to the base excision repair pathway have been demonstrated to repair these mutations. Recent evidence suggests that the mismatch repair pathway (MMR might also repair nitric oxide-induced DNA damage. Since deficiency in MMR predisposes to colon cancer, we hypothesized that MMR-deficient colon epithelial cells are incapable of repairing nitric-oxide induced genetic lesions that can promote colon cancer. Indeed, we found that the MMR pathway repairs nitric oxide-induced DNA mutations in cell lines. To test whether nitric oxide promotes colon cancer, we genetically ablated the inducible nitric oxide synthase (iNOS or inhibited iNOS activity in the APC(Min/+Msh2(-/- mouse model of colon cancer. However, despite the fact that nitric oxide production was strongly reduced in the colon using both approaches, colon cancer incidence was not affected. These data show that nitric oxide and iNOS do not promote colon cancer in APC(Min/+Msh2(-/- mice.

  11. Protein kinase A antagonist inhibits β-catenin nuclear translocation, c-Myc and COX-2 expression and tumor promotion in ApcMin/+ mice

    Directory of Open Access Journals (Sweden)

    Brudvik Kristoffer W

    2011-12-01

    Full Text Available Abstract Background The adenomatous polyposis coli (APC protein is part of the destruction complex controlling proteosomal degradation of β-catenin and limiting its nuclear translocation, which is thought to play a gate-keeping role in colorectal cancer. The destruction complex is inhibited by Wnt-Frz and prostaglandin E2 (PGE2 - PI-3 kinase pathways. Recent reports show that PGE2-induced phosphorylation of β-catenin by protein kinase A (PKA increases nuclear translocation indicating two mechanisms of action of PGE2 on β-catenin homeostasis. Findings Treatment of ApcMin/+ mice that spontaneously develop intestinal adenomas with a PKA antagonist (Rp-8-Br-cAMPS selectively targeting only the latter pathway reduced tumor load, but not the number of adenomas. Immunohistochemical characterization of intestines from treated and control animals revealed that expression of β-catenin, β-catenin nuclear translocation and expression of the β-catenin target genes c-Myc and COX-2 were significantly down-regulated upon Rp-8-Br-cAMPS treatment. Parallel experiments in a human colon cancer cell line (HCT116 revealed that Rp-8-Br-cAMPS blocked PGE2-induced β-catenin phosphorylation and c-Myc upregulation. Conclusion Based on our findings we suggest that PGE2 act through PKA to promote β-catenin nuclear translocation and tumor development in ApcMin/+ mice in vivo, indicating that the direct regulatory effect of PKA on β-catenin nuclear translocation is operative in intestinal cancer.

  12. Ultra-large scale synthesis of high electrochemical performance SnO2 quantum dots within 5 min at room temperature following a growth self-termination mechanism

    International Nuclear Information System (INIS)

    Highlights: • SnO2 quantum dots were prepared at an ultra-large scale at room temperature within 5 min. • The grinding of SnCl2⋅2H2O and ammonium persulphate with morpholine produces quantum dots. • The reactions were self-terminated through the rapid consumption of water. • The obtained SnO2 quantum dots own high electrochemical performance. - Abstract: SnO2 quantum dots are prepared at an ultra-large scale by a productive synthetic procedure without using any organic ligand. The grinding of solid mixture of SnCl2⋅2H2O and ammonium persulphate with morpholine in a mortar at room temperature produces 1.2 nm SnO2 quantum dots within 5 min. The formation of SnO2 is initiated by the reaction between tin ions and hydroxyl groups generated from hydrolysis of morpholine in the released hydrate water from SnCl2⋅2H2O. It is considered that as water is rapidly consumed by the hydrolysis reaction of morpholine, the growth process of particles is self-terminated immediately after their transitory period of nucleation and growth. As a result of simple procedure and high toleration to scaling up of preparation, at least 50 g of SnO2 quantum dots can be produced in one batch in our laboratory. The as prepared quantum dots present high electrochemical performance due to the effective faradaic reaction and the alternative trapping of electrons and holes

  13. Academic Experience of Professor Panzhi-min in Treating Abdominal Masses%潘智敏教授治疗积证的学术经验

    Institute of Scientific and Technical Information of China (English)

    袁国荣

    2011-01-01

    潘智敏教授系第四批全国名老中医药学术经验继承指导老师,博士研究生导师,临证30余年,学验俱丰,其在治疗积证方面积累了丰富的学术经验.潘智敏教授在继承前人积证学说的基础上,结合时代、地域特点和长期的临床经验,拓展了积证的范畴,提出了现代积证的病因病机特点,总结了新五积说,研制了治疗各种积证的基本方:五积方.并运用五积方加减治疗各种积证,取得了较好的临床疗效.%Professor Pan zhi - min is the guidance teacher of the 4th Famous TCM Experts Academic Experience and doctoral Advisor. She has clinical experience over 30 years and is high in academic level. Especially she has rich Academic experience in treating Abdominal Masses. On the base of forearms' theory of Abdominal Masses, Professor Pan zhi - min expanded domain of Abdominal Masses , developed characteristic of pathogeny and pathomechanism of morden Abdominal Masses, summarized'new wuji theory and developed basic prescription in treating all kinds of Abdominal Masses: wuji recepto according to characteristic of times and regions and long - time clinical experience. She has cured all kinds of Abdominal Masses by use of wuji recepto and its clinical curative effect was good.

  14. Ryanodine receptor type I and nicotinic acid adenine dinucleotide phosphate receptors mediate Ca2+ release from insulin-containing vesicles in living pancreatic beta-cells (MIN6).

    Science.gov (United States)

    Mitchell, Kathryn J; Lai, F Anthony; Rutter, Guy A

    2003-03-28

    We have demonstrated recently (Mitchell, K. J., Pinton, P., Varadi, A., Tacchetti, C., Ainscow, E. K., Pozzan, T., Rizzuto, R., and Rutter, G. A. (2001) J. Cell Biol. 155, 41-51) that ryanodine receptors (RyR) are present on insulin-containing secretory vesicles. Here we show that pancreatic islets and derived beta-cell lines express type I and II, but not type III, RyRs. Purified by subcellular fractionation and membrane immuno-isolation, dense core secretory vesicles were found to possess a similar level of type I RyR immunoreactivity as Golgi/endoplasmic reticulum (ER) membranes but substantially less RyR II than the latter. Monitored in cells expressing appropriately targeted aequorins, dantrolene, an inhibitor of RyR I channels, elevated free Ca(2+) concentrations in the secretory vesicle compartment from 40.1 +/- 6.7 to 90.4 +/- 14.8 microm (n = 4, p < 0.01), while having no effect on ER Ca(2+) concentrations. Furthermore, nicotinic acid adenine dinucleotide phosphate (NAADP), a novel Ca(2+)-mobilizing agent, decreased dense core secretory vesicle but not ER free Ca(2+) concentrations in permeabilized MIN6 beta-cells, and flash photolysis of caged NAADP released Ca(2+) from a thapsigargin-insensitive Ca(2+) store in single MIN6 cells. Because dantrolene strongly inhibited glucose-stimulated insulin secretion (from 3.07 +/- 0.51-fold stimulation to no significant glucose effect; n = 3, p < 0.01), we conclude that RyR I-mediated Ca(2+)-induced Ca(2+) release from secretory vesicles, possibly potentiated by NAADP, is essential for the activation of insulin secretion.

  15. 不同浓度 DMSO 对 Min6胰岛细胞活力和ROS 产生的影响%The effects of DMSO on cell viability and reactive oxygen species production in Min6 islet cell

    Institute of Scientific and Technical Information of China (English)

    张红; 张丽; 张燕; 张之

    2015-01-01

    Objective To observe the effects of dimethyl sulfoxide on Min6 islet cell viability and Reactive Oxygen Species Production (ROS).Methods Min6 islet cell was cultured under sterile clean environment condition,then interfered by DMSO of different concentration,Cell Counting Kit-8 was adopted to detect the cell viability,DCFH-DA probe was used to detect the Production of ROS.Results Compared with 0%DMSO group ,Min6 cell viability decreased in group containing DMSO 0.005%,0.0125%,0.05%, 0.125%,0.25%,there was little difference of cell viability between groups containing 0.005%,0.0125%, 0.05%,0.125% DMSO.Cell viability decreased further in 0.25% DMSO group,at the the same time ROS production increased.Conclusion Min6 cell sensitive to DMSO,different concentration of DMSO may have different influence on cell viability and intracellular ROS level.it is suggested that to keep the same con-centration of DMSO in different group or wrong conclusion may be get.%目的:观察不同浓度二甲基亚砜(DMSO)对 Min6胰岛细胞活力和细胞活性氧族(ROS)产生的影响。方法无菌洁净环境下培养 Min6胰岛细胞株,细胞良好生长状态时,分为正常对照组(DMSO 含量为0%)及DMSO 各浓度组,用不同浓度 DMSO(0.005%、0.0125%、0.05%、0.125%、0.25%)干预 Min6胰岛细胞48 h,采用细胞增殖和毒性检测试剂盒(Cell Counting Kit-8,CCK8法)检测细胞活力,采用2′,7′-二氯荧光黄双乙酸盐(DCFH-DA)探针法检测 ROS 的产生水平。结果与正常对照组比较(不含 DMSO),0.005%、0.0125%、0.05%、0.125%,0.25% DMSO 组细胞活力均降低;0.005%、0.0125%、0.05%、0.125% DMSO 组间细胞活力差别不大,0.25%DMSO组细胞活力进一步下降,同时 ROS 产生明显增加。结论Min6细胞对 DMSO 敏感,DMSO 浓度水平对细胞活力、ROS 水平有一定影响,建

  16. "Mu vend mu õde ja mina põgeneme Valguskoonused kalduvad ..." = "Min bror min syster och jag flyr Ljuskäglor välter över vägkanten ..." : [luuletused] / Catharina Gripenberg ; tlk. Juta-Tiia Mägi

    Index Scriptorium Estoniae

    Gripenberg, Catharina

    2004-01-01

    Sisu: "Mu vend mu õde ja mina põgeneme Valguskoonused kalduvad ..." = "Min bror min syster och jag flyr Ljuskäglor välter över vägkanten ..."; "Tean, et kajad vastavad, aga väga lühidalt. Valad sa välja oma ..." = "Vet att ekon svarar, men i all korthet. Gjuter du ut ditt hjärta ..."; "Kirjasõber, ma otsin välja jääkraabitsa ..." = "Brevvän, jag lagrar upp med fönsterskapare ..."; "Säravselge hommik. Linnupojad trügivad välja kolbast ..." = "Det var en glasklar morgon. Fågelungarna knuffas från skallen ..."; Armastuskiri = Kärleksbrev

  17. Ensemble feature selection using min-max strategy%基于最小最大策略的集成特征选择

    Institute of Scientific and Technical Information of China (English)

    周国静; 李云

    2014-01-01

    特征选择是机器学习和数据挖掘中的一个关键问题,它可以实现数据维度的约减,从而提高学习模型的泛化能力。近年来,为了提高特征选择算法的性能,集成思想被应用到特征选择算法中,即将多个基特征选择器进行集成。本文从提高特征选择算法对大规模数据处理能力的角度出发,提出了一种基于最小最大策略的集成特征选择方法。它主要包括三个步骤:第一,将原始数据根据类别信息划分成多个相对较小的平衡数据子集;第二,在每一个数据子集上进行特征选择,得到多个特征选择结果;第三,对多个特征选择结果依据最小-最大策略进行集成,得出最终的特征选择结果。通过实验对比了该集成策略与其它三种集成策略对分类准确率的影响,结果表明最小最大集成策略在大部分情况下能够获得较好的性能,且基于最小最大策略的集成特征选择可以有效处理大规模数据。%Feature selection is one of the key problems in machine learning and data mining.It involves identifying a subset of the most useful features that produces compatible results as the original entire set of features.It can reduce the dimensionality of original data,speed up the learning process and build comprehensible learning models with good generalization performance.Nowadays,ensemble idea has been used to improve the performance of feature selection by integrating multiple base feature selection models into an ensemble one.It turned out to be effective in dealing with high dimensionality small sample size problem especially for robust biomarker identification.In this paper,we aim to improve the efficiency of feature selection in dealing with large scale problems.In order to deal with such problems,ensemble feature selection using min-max strategy is proposed.The method consists of three main steps:firstly,the original data is decomposed into a

  18. Model of the impact of parameters controlling replenishment in the bs (min-max continuous review system on the actual inventory availibility

    Directory of Open Access Journals (Sweden)

    Stanisław Krzyżaniak

    2015-09-01

    Full Text Available Background: Due to random changes in demand, inventory management is still - despite the development of alternative goods flow management concepts - an important issue both in terms of costs of maintenance and replenishment as well as the level of service measured by inventory availability levels. There are a number of replenishment systems to be used in such conditions, but they are most often formed on the basis of two basic ones: a system based on the reorder point and based on periodic inspection.  This paper refers to the former system, the BS system (min-max, in which an order is placed after reaching inventory level B (information level, reorder point for a quantity allowing to reach level S. This system is very often used in business practice. Observations conducted under realistic conditions indicate the need to improve the classical models describing the system.  This results, among other things, from the fact that the actual level of available inventory at the start of the replenishment cycle may be significantly lower than level B, resulting in lower than expected levels of customer service. Taking account of this phenomenon through model determination of the cumulative distribution function for the observed difference makes it possible to select the correct parameters to control the replenishment system in question and - therefore - to achieve the expected economic effects. Methods: The object of the study is to create a mathematical model allowing the determination of the required inventory level B taking into account the difference D between this level and the actual level of inventory at the start of the replenishment cycle.  To determine the effect of various factors such as demand distribution parameters in the adopted unit of time and the difference between level S (max and B (min, a dedicated tool (simulator in EXCEL spreadsheet for determining the distribution of frequency of value D has been developed.  Then a

  19. Inhibition of intestinal adenoma formation in APC(Min/+ mice by Riccardin D, a natural product derived from liverwort plant Dumortiera hirsuta.

    Directory of Open Access Journals (Sweden)

    Hui-Ping Liu

    Full Text Available BACKGROUND: Mutation of tumor suppressor gene, adenomatous polyposis coli (APC, is the primary molecular event in the development of most intestinal carcinomas. Animal model with APC gene mutation is an effective tool for study of preventive approaches against intestinal carcinomas. We aimed to evaluate the effect of Riccardin D, a macrocyclic bisbibenzyl compound, as a chemopreventive agent against intestinal adenoma formation in APC(Min/+ mice. METHODS: APC(Min/+ mice were given Riccardin D by p.o. gavage for 7 weeks. Mice were sacrificed, and the number, size and histopathology of intestinal polyps were examined under a microscope. We performed immunohistochemical staining, western blotting, reverse transcriptase-polymerase chain reaction (RT-PCR and enzyme-linked immunosorbent assay (ELISA in intestinal polyps to investigate the mechanism of chemopreventive effect of Riccardin D. RESULTS: Riccardin D treatment resulted in a significant inhibition of intestinal adenoma formation, showing a reduction of polyp number by 41.7%, 31.1% and 44.4%, respectively, in proximal, middle and distal portions of small intestine. The activity of Riccardin D against polyp formation was more profound in colon, wherein Riccardin D decreased polyp number by 79.3%. Size distribution analysis revealed a significant reduction in large-size polyps (2-3 mm by 40.0%, 42.5% and 33.3%, respectively, in proximal, middle and distal portions of small intestine, and 77.8% in colon. Histopathological analysis of the intestinal polyps revealed mostly hyperplastic morphology without obvious dysplasia in Riccardin D-treated mice. Molecular analyses of the polyps suggested that the inhibitory effect of Riccardin D on intestinal adenoma formation was associated with its abilities of reduction in cell proliferation, induction of apoptosis, antiangiogenesis, inhibition of the Wnt signaling pathway and suppression of inflammatory mediators in polyps. CONCLUSIONS: Our results

  20. Min-merchants Trade at the Beginning of the Globalization%全球化初期的闽商贸易

    Institute of Scientific and Technical Information of China (English)

    周璐

    2014-01-01

    Since ancient times, Fujian has always been an important facilitator and participants in globalization. As early as 1500 years ago, as the rich marine characteristics and spirit of adventure business organization, Min-merchants has been active in Fujian and the Asian countries in trade, and even came into Arabia and Africa area. The commodity trade they driven led indirectly to the opening of the new sea route, which made the Europeans enter into the global trade. The circle of foreign trade also had the expanding development with the Europeans' participation. But in this process, always the same, no matter when, as the representative of the China businessmen, Min-merchants had been active in each trade circle in the formation of this world economic system, and they had been always around the Chinese southeast coastal expansion with Fujian as the center.%自古以来,闽商一直是全球化的重要推动者与参与者。早在1500年以前,具有浓郁海洋特色和冒险精神的商帮---闽商就已开始活跃于与亚洲诸国的贸易中,甚至深入到了阿拉伯乃至非洲地区,正是他们所带动的商品贸易间接促使了新航路的开辟,使得欧洲人得以进入到全球化的贸易中来,由闽商开辟的对外贸易圈也随着欧洲人的进入不断扩大。但在这一过程中,始终不变的是,不论何时,在这个全球世界经济体系中形成的各个贸易圈都始终是以闽商为代表的中国商人围绕着以福建为中心的中国东南沿海展开的。

  1. Coordinated Analyses of Antarctic Sediments as Mars Analog Materials Using Reflectance Spectroscopy and Current Flight-Like Instruments for CheMin, SAM and MOMA

    Science.gov (United States)

    Bishop, Janice L.; Franz, Heather B.; Goetz, Walter; Blake, David F.; Freissinet, Caroline; Steininger, Harald; Goesmann, Fred; Brinckerhoff, William B.; Getty, Stephanie; Pinnick, Veronica T.; Mahaffy, Paul R.; Dyar, M. Darby

    2013-01-01

    Coordinated analyses of mineralogy and chemistry of sediments from the Antarctic Dry Valleys illustrate how data obtained using flight-ready technology of current NASA and ESA missions can be combined for greater understanding of the samples. Mineralogy was measured by X-ray diffraction (XRD) and visible/ near-infrared (VNIR) reflectance spectroscopy. Chemical analyses utilized a quadrupole mass spectrometer (QMS) to perform pyrolysis-evolved gas analysis (EGA) and gas chromatography-mass spectrometry (GC/MS) both with and without derivatization, as well as laser desorption-mass spectrometry (LD/MS) techniques. These analyses are designed to demonstrate some of the capabilities of near-term landed Mars missions, to provide ground truthing of VNIR reflectance data acquired from orbit by the Compact Reconnaissance Imaging Spectrometer for Mars (CRISM) on MRO and to provide detection limits for surface- operated instruments: the Chemistry and Mineralogy (CheMin) and Sample Analysis at Mars (SAM) instrument suites onboard Mars Science Laboratory (MSL) and the Mars Organic Molecule Analyzer (MOMA) onboard ExoMars-2018. The new data from this study are compared with previous analyses of the sediments performed with other techniques. Tremolite was found in the oxic region samples for the first time using the CheMin-like XRD instrument. The NIR spectral features of tremolite are consistent with those observed in these samples. Although the tremolite bands are weak in spectra of these samples, spectral features near 2.32 and 2.39 micrometers could be detected by CRISM if tremolite is present on the martian surface. Allophane was found to be a good match to weak NIR features at 1.37-1.41, 1.92, and 2.19 micrometers in spectra of the oxic region sediments and is a common component of immature volcanic soils. Biogenic methane was found to be associated with calcite in the oxic region samples by the SAM/EGA instrument and a phosphoric acid derivative was found in the anoxic

  2. Regulation of gene expression by glucose in pancreatic beta -cells (MIN6) via insulin secretion and activation of phosphatidylinositol 3'-kinase.

    Science.gov (United States)

    da Silva Xavier, G; Varadi, A; Ainscow, E K; Rutter, G A

    2000-11-17

    Increases in glucose concentration control the transcription of the preproinsulin (PPI) gene and several other genes in the pancreatic islet beta-cell. Although recent data have demonstrated that secreted insulin may regulate the PPI gene (Leibiger, I. B., Leibiger, B., Moede, T., and Berggren, P. O. (1998) Mol. Cell 1, 933-938), the role of insulin in the control of other beta-cell genes is unexplored. To study the importance of insulin secretion in the regulation of the PPI and liver-type pyruvate kinase (L-PK) genes by glucose, we have used intranuclear microinjection of promoter-luciferase constructs into MIN6 beta-cells and photon-counting imaging. The activity of each promoter was increased either by 30 (versus 3) mm glucose or by 1-20 nm insulin. These effects of insulin were not due to enhanced glucose metabolism since culture with the hormone had no impact on the stimulation of increases in intracellular ATP concentration caused by 30 mm glucose. Furthermore, the islet-specific glucokinase promoter and cellular glucokinase immunoreactivity were unaffected by 30 mm glucose or 20 nm insulin. Inhibition of insulin secretion with the Ca(2+) channel blocker verapamil, the ATP-sensitive K(+) channel opener diazoxide, or the alpha(2)-adrenergic agonist clonidine blocked the effects of glucose on L-PK gene transcription. Similarly, 30 mm glucose failed to induce the promoter after inhibition of phosphatidylinositol 3'-kinase activity with LY294002 and the expression of dominant negative-acting phosphatidylinositol 3'-kinase (Deltap85) or the phosphoinositide 3'-phosphatase PTEN (phosphatase and tensin homologue). LY294002 also diminished the activation of the L-PK gene caused by inhibition of 5'-AMP-activated protein kinase with anti-5'-AMP-activated protein kinase alpha2 antibodies. Conversely, stimulation of insulin secretion with 13 mm KCl or 10 microm tolbutamide strongly activated the PPI and L-PK promoters. These data indicate that, in MIN6 beta

  3. Motivational interviewing for screening and feedback and encouraging lifestyle changes to reduce relative weight in 4-8 year old children: design of the MInT study

    Directory of Open Access Journals (Sweden)

    Taylor Barry J

    2010-05-01

    Full Text Available Abstract Background Because parental recognition of overweight in young children is poor, we need to determine how best to inform parents that their child is overweight in a way that enhances their acceptance and supports motivation for positive change. This study will assess 1 whether weight feedback delivered using motivational interviewing increases parental acceptance of their child's weight status and enhances motivation for behaviour change, and 2 whether a family-based individualised lifestyle intervention, delivered primarily by a MInT mentor with limited support from "expert" consultants in psychology, nutrition and physical activity, can improve weight outcomes after 12 and 24 months in young overweight children, compared with usual care. Methods/Design 1500 children aged 4-8 years will be screened for overweight (height, weight, waist, blood pressure, body composition. Parents will complete questionnaires on feeding practices, physical activity, diet, parenting, motivation for healthy lifestyles, and demographics. Parents of children classified as overweight (BMI ≥ CDC 85th will receive feedback about the results using Motivational interviewing or Usual care. Parental responses to feedback will be assessed two weeks later and participants will be invited into the intervention. Additional baseline measurements (accelerometry, diet, quality of life, child behaviour will be collected and families will be randomised to Tailored package or Usual care. Parents in the Usual care condition will meet once with an advisor who will offer general advice regarding healthy eating and activity. Parents in the Tailored package condition will attend a single session with an "expert team" (MInT mentor, dietitian, physical activity advisor, clinical psychologist to identify current challenges for the family, develop tailored goals for change, and plan behavioural strategies that best suit each family. The mentor will continue to provide support to the

  4. 1500 r/min核电汽轮机71英寸末级叶片的研发%Development of 1500 r/min 71 Inch Low Pressure End Blade

    Institute of Scientific and Technical Information of China (English)

    管继伟; 张秋鸿; 李宇峰; 刘长春

    2016-01-01

    简要介绍了哈汽公司1500r/min核电汽轮机71英寸末级叶片在气动、结构和频率特性等方面的设计思路,特别介绍了遵循叶片模化设计相似准则由1500r/min71英寸叶片模化设计的3000 r/min35.5英寸叶片的运行业绩,由此证明了1500r/min71英寸叶片的安全可靠性。%The 1500r/min 71 inch nuclear power steam turbine low pressure end blade has been developed by HTC with advanced design feature of aerodynamic ,structure and frequency character .A 3000 r/min 35.5 inch blade for combined cycle power plant steam turbine is obtained from the 1500 r/min 71 inch blade by law of similarity scale .Application practice of the 3000 r/min 35.5 inch blade for combined cycle power plant steam turbine has provided proof of safety of 1500r/min 71 inch blade.

  5. 潘智敏教授理瘀的学术经验%Academic Experience of Professor PAN Zhi-min on Curing Stasis

    Institute of Scientific and Technical Information of China (English)

    袁国荣; 潘智敏

    2011-01-01

    Professor PAN Zhi - min is the guidance teacher of the 4th Famous TCM Expert's Academic Experience and doctoral Advisor. She is a student of Professor YANG Ji - sun, the Famous TCM Expert and has a great deal of experience on treating stasis. On the basis of forearms'theory of stasis, professor pan summarized ten types of stasis and stated characteristic of aged disease with stasis. Finally she brought forward suggestions and experienced drugs on curing stasis.%潘智敏教授系第四批全国名老中医药学术经验继承指导老师,博士生导师,得著名中医临床学家杨继荪教授的真传,临证30余年,学验俱丰,其对瘀证的研究,造诣较深.潘智敏教授在继承前人瘀证学说的基础上,总结了瘀证10型,提出了理瘀的对策和经验用药.

  6. A max-to-min technique for making projections of NDVI change in semi-arid Africa for food security early warning

    Science.gov (United States)

    Brown, M. E.; Funk, C. C.

    2005-12-01

    Climatic hazards such as droughts and floods often result in a decline in food production in economically vulnerable pre-industrial economies such as those in Africa. Early warning systems (EWS) have been developed to identify slow onset disasters such famine and epidemic disease that may result from hazardous environmental conditions. These conditions often precede food crises by many months, thus effective monitoring via satellite and in situ observations can allow for successful mitigation activities. Accurate forecasts of NDVI could increase monitoring lead times and allow for effective institutional planning of intervention, making early warning earlier. This paper presents a simple empirical max-to-min model for making 1 to 4 month NDVI projections. These statistical projections are based on parameterized satellite rainfall estimates (RFE) and relative humidity demand (RHD). A heuristic example in central Zimbabwe introduces the RFE growth and RHD loss terms. A quasi-global, one month ahead, 1 degree study then demonstrates reasonable accuracies in many semi-arid regions. In Africa, a 0.1 degree cross-validated skill assessment quantifies the technique's applicability at 1 to 4 month forecast intervals. These results suggest that useful projections can be made over many semi-arid, food insecure regions of Africa, with plausible extensions to drought prone areas of Asia, Australia and South America.

  7. ZHAO Xue-min Folk Medicine Achievements%赵学敏在民间医药学方面的成就

    Institute of Scientific and Technical Information of China (English)

    赵军

    2011-01-01

    ZHAO Xue-min is Qing Dynasty renowned medicine scientist, in its extant work Native Chinese Plants Appropriated lost articles and String Elegant has preserved the massive folk medicine precious content, the collection, the reorganization, summarized the massive folk medicine experience, the massive folk single proven prescription, specially walked Fang Yi the prevention disease's experience, this studied the folk medicine for us the development, has provided the very valuable material.%赵学敏是清代著名的医药学家,在其现存的著作《本草纲目拾遗》和《串雅》中保存了大量民间医药学的宝贵内容,收集、整理、总结了大量民间医药学经验,大量的民间单验方,特别是走方医的防治疾病的经验,这为我们研究民间医药学的发展,提供了十分可贵的资料.

  8. Preliminary Inquiry on the Modern Culture Value of the Southern Min Pat Chest Dance%闽南拍胸舞现代文化价值初探

    Institute of Scientific and Technical Information of China (English)

    吴红叶

    2012-01-01

    拍胸舞是流行于福建南部沿海地区的民间舞蹈,其风格独特、色彩浓郁、自娱性强。在时代的发展及历史沉淀中,拍胸舞的表演形态与舞蹈功能都有了不同程度的丰富与改变。作为闽南代表性民间舞蹈,拍胸舞有着文化的传承与保护价值。同时,作为一项旅游文化资源,其对外文化交流价值也不容忽视。%"Pat Chest Dance" is a kind of folk dance which is popular in the coastal areas of Southern Fujian, it has unique style and strong entertainment. With the development of the times, the form of the chest percussion dance and performing function have different levels of wealth and change. As the Southern Min the most representa- tive folk dance, pat chest dance cultural heritage and conservation value. As a tourism and cultural resources, its cultural exchanges with foreign value can not be ignored.

  9. Estimated preejection period (PEP) based on the detection of the R-wave and dZ/dt-min peaks in ECG and ICG

    Science.gov (United States)

    van Lien, René; Schutte, Nienke M.; Meijer, Jan H.; de Geus, Eco J. C.

    2013-04-01

    The validity of estimating the PEP from a fixed value for the Q-wave onset to the R-wave peak (QR) interval and from the R-wave peak to the dZ/dt-min peak (ISTI) interval is evaluated. Ninety-one subjects participated in a laboratory experiment in which a variety of physical and mental stressors were presented and 31 further subjects participated in a sequence of structured ambulatory activities in which large variation in posture and physical activity was induced. PEP, QR interval, and ISTI were scored. Across the diverse laboratory and ambulatory conditions the QR interval could be approximated by a fixed interval of 40 ms but 95% confidence intervals were large (25 to 54 ms). Multilevel analysis showed that 79% to 81% of the within and between-subject variation in the RB interval could be predicted by the ISTI. However, the optimal intercept and slope values varied significantly across subjects and study setting. Bland-Altman plots revealed a large discrepancy between the estimated PEP and the actual PEP based on the Q-wave onset and B-point. It is concluded that the estimated PEP can be a useful tool but cannot replace the actual PEP to index cardiac sympathetic control.

  10. Localized field-aligned currents and 4-min TEC and ground magnetic oscillations during the 2015 eruption of Chile's Calbuco volcano

    Science.gov (United States)

    Aoyama, Tadashi; Iyemori, Toshihiko; Nakanishi, Kunihito; Nishioka, Michi; Rosales, Domingo; Veliz, Oscar; Safor, Erick Vidal

    2016-08-01

    The Calbuco volcano in southern Chile erupted on April 22, 2015. About 2 h after the first eruption, a Swarm satellite passed above the volcano and observed enhancement of small-amplitude (~0.5 nT) magnetic fluctuations with wave-packet structure which extends 15° in latitude. Similar wave packet is seen at the geomagnetic conjugate point of the volcano. Just after the eruption, geomagnetic fluctuations with the spectral peaks around the vertical acoustic resonance periods, 215 and 260 s, were also observed at Huancayo Geomagnetic Observatory located on the magnetic equator. Besides these observations, around 4-min, i.e., 175, 205 and 260 s, oscillations of total electron content (TEC) were observed at global positioning system stations near the volcano. The horizontal propagation velocity and the spatial scale of the TEC oscillation are estimated to be 720 m/s and 1600 km, respectively. These observations strongly suggest that the atmospheric waves induced by explosive volcanic eruption generate TEC variation and electric currents. The Swarm observation may be explained as a manifestation of their magnetic effects observed in the topside ionosphere.

  11. Fluxo de material fragmentado em passagem de minério nas minas subterrâneas: a prática corrente

    Directory of Open Access Journals (Sweden)

    José Margarida da Silva

    2006-09-01

    Full Text Available Esse trabalho é parte de pesquisa realizada para preparação de tese de doutorado e apresenta estudo do fluxo por gravidade de material fragmentado em mineração subterrânea. É descrita a prática corrente em minas brasileiras e estrangeiras, enfocando os índices de acidentes, as ações preventivas e corretivas nas operações que utilizam o fluxo por gravidade de minério desmontado em passagens, presentes em diversos métodos de lavra, como na lavra por subníveis, por corte e enchimento e nos métodos que utilizam o abatimento controlado do teto da escavação subterrânea.This article shows some results of a doctorate thesis about the gravity flow of bulk material in an underground mine. It describes the practices in Brazilian mines and in other countries, focusing on accident data, preventive and corrective actions, in mining operations that use gravity flow to transport fragmented material from the excavation of ore passes in several mining operations, such as in underground mining using cut and fill methods and caving methods.

  12. Caracterização tecnológica de rejeito de minério de ferro Technological characterization of iron ore tailing

    Directory of Open Access Journals (Sweden)

    Marcos Antônio Gomes

    2011-06-01

    Full Text Available Nesse trabalho, é apresentada a caracterização dos finos, estocados na barragem I como rejeito proveniente do tratamento de minério ferro. Na caracterização das amostras, estão apresentadas análises granulométricas por peneiramento a úmido, análises químicas por espectrometria de plasma e análise mineralógica por difração de raios X. De posse das análises de caracterização, foram executados ensaios tecnológicos, visando à obtenção de concentrado para aplicação na indústria metalúrgica. Foram avaliadas duas rotas de concentração em escala de bancada: uma (rota I constando de classificação (0,15mm, separação magnética (-1,0+0,15mm, deslamagem e flotação (-0,15mm e outra (rota II constando de separação magnética (-1,0mm total. De acordo com a distribuição granulométrica dos finos do minério de ferro, 8,21% das partículas encontram-se retidas em 0,150mm e 58,81% abaixo de 0,045mm. A amostra, conforme Tabela 1, apresenta teores médios (calculado de 48,08% de Fe, 20,58% de SiO2, 3,16% de Al2O3. Os minerais portadores de ferro identificados foram hematita, martita, magnetita e goethita e os minerais de ganga foram quartzo, gibbisita e caolinita. A melhor opção de concentração estudada consistiu na utilização de circuito de concentração somente por separação magnética, rota II. A recuperação em massa e metalúrgica foram, respectivamente, 68,00% e 90,81%, apresentando um concentrado com 67,54% de Fe, 1,50% de SiO2 e 0,49% de Al2O3, atendendo a especificação do produto comercializado pela empresa.This paper addresses the characterization of fines stocked in a pond as tailings from an iron ore concentrator. The characterization consisted of size analyses by wet screening, chemical analyses by ICP, and mineralogical analyses by X-ray diffraction. The next stage consisted of technological tests. Two concentration routes were evaluated at bench scale: the first (route I consisting of classification

  13. Emprego de resíduos siderúrgicos e pellet feed minipelotizados na sinterização de minério de ferro

    Directory of Open Access Journals (Sweden)

    Eduardo Reis de Oliveira

    2003-12-01

    Full Text Available Em metalurgia extrativa, a grande maioria dos processos de fabricação de ferro gusa nos altos-fornos usa como fonte de ferro minérios granulados e/ou aglomerados. O processo de sinterização foi projetado com o objetivo inicial do aproveitamento de minérios e combustíveis com granulometria inferiores a 6 mm. Essas frações não podem ser utilizadas diretamente nos altos-fornos, por comprometerem a permeabilidade da carga, dificultando a passagem dos gases, condição imprescindível a um bom desempenho desse equipamento. No processo convencional, toda a matéria-prima da sinterização é alimentada na forma de finos para a produção de sínter. A alternativa pesquisada foi a fabricação de minipelotas utilizando em sua composição resíduos siderúrgicos sólidos e de pellet feed, visando à substituição parcial do sínter feed por pellet feed. Para atingir tais objetivos, foram usados resíduos siderúrgicos, pellet feed alimentados na unidade de sinterização da empresa CST (Companhia Siderúrgica de Tubarão. A metodologia de pesquisa foi formulada e experimentada visando à viabilidade técnica e econômica da proposta apresentada.Into extractive metallurgy, the large number of the processes of production of pig iron into the blast furnaces has used like iron search, granulated and/or agglomerated material. The sinterization process has designed with the initial purpose the use of ore and fuels with inferior granulometry than 6 mm. These fractions can not be used directly into the blast furnace once they put in risk the permeability of the load, what becomes difficult the passage of the gases, indispensable condition in order to a good performance of this equipment. Into the conventional process, all the raw material from the sinterization has been fed in the form of ore fines to the production of sinter. The researched alternative had been the production of mini-pellets that use in their composition solid residuals from

  14. 肝脏脱细胞支架与MIN6细胞三维共培养移植治疗Ⅰ型糖尿病实验研究%Three dimensional co-culture of MIN6 cells and liver-derived perfusion-decellularized bioscaffold for potential clinical practice

    Institute of Scientific and Technical Information of China (English)

    朱沙俊; 王雷

    2015-01-01

    目的:通过体外制备小鼠肝脏脱细胞支架并种植MIN6细胞,观测其定植生长并检测其功效发挥,为体外构建胰岛素分泌器官提供理论基础。方法:灌注法制备全肝脏脱细胞支架,将小鼠MIN6细胞种植入支架中于三维培养体系中培养,通过苏木精-伊红染色、胰岛素免疫组化分析及荧光定量聚合酶链反应检测其功效。检测MIN6细胞功能基因Insulin表达。将种植MIN6细胞的肝脏脱细胞支架移植入糖尿病小鼠体内,监测其功能发挥并初步评估其疗效。结果:体外成功制备肝脏脱细胞支架,在保留其原有脉管网络基础上,未见组织残留。HE染色显示肝脏脱细胞支架内没有细胞核染,且脉管结构保存完整。扫描电镜未见细胞结构,支架保存完整胶原纤维形态。MIN6细胞在脱细胞支架中三维培养后,检测胰岛素基因表达水平,结果和平面培养相比较,差异具有统计学意义(P<0.05)。将种植MIN6细胞的肝脏脱细胞支架移植入糖尿病小鼠体内能够较好的发挥降血糖作用。结论:通过将MIN6细胞种植入肝脏脱细胞支架并三维培养,可构建体外胰岛素分泌体系。%Objective:To observe the growth and function of primary mouse islets in the liver decellularized bioscaf-fold (LDB). At the same time, a new method of tissue engineering for treatment of diabetes was explored. Methods: The whole mouse liver was perfused by using detergent through hepatic portal vein in a continuous way and the whole liver de-cellularized bioscaffold was manufactured with the complete structure. The MIN6 cells cultured in the 3D bioscaffold. Then the hematoxylin-eosin (HE) staining, insulin immunohistochemical analysis and fluorescence quantitative polymerase chain reaction (PCR) were performed. qRT-PCR was conducted for the functional gene of INS1 and INS2 to further illuminate its function. The function of the recellularized

  15. The clinical application of combined analysis of neonatal umbilical artery blood pH and 1 min Apgar score%新生儿脐动脉血pH值联合1 min Apgar评分检测的应用

    Institute of Scientific and Technical Information of China (English)

    刘晓静

    2015-01-01

    目的 探讨新生儿脐动脉血pH值联合1 min Apgar检测的应用价值.方法 选取分娩新生儿206例为研究对象,其中临床诊断胎儿窘迫92例,无胎儿窘迫114例.胎儿娩出后立即行脐动脉血气分析和1 min Apgar评分,依据是否胎儿窘迫和1 min Apgar评分分组,并追踪新生儿结局.结果 (1)胎儿窘迫组中脐动脉血pH值<7.20者70例(76.1%),无胎儿窘迫组中为56例(49.1%),差异有统计学意义(P<0.01).(2)新生儿1 min Apgar评分>7分者中脐动脉血pH值<7.20者46例(40.4%),而Apgar评分≤7分者中为73例(79.3%),差异有统计学意义(P<0.01).(3)脐动脉血气及Apgar评分对新生儿缺血缺氧性脑病(HIE)的预测:HIE发生26例.Apgar评分≤7分对HIE诊断敏感度为88.5%,特异性为61.7%;pH值<7.20对HIE诊断的敏感度76.9%,特异性45.0%.联合检测对HIE诊断的敏感性为90.5%,特异性为55.0%.结论 血气分析是Apgar评分的补充,二者结合能增加对HIE诊断的特异性.

  16. Mineralogy, provenance, and diagenesis of a potassic basaltic sandstone on Mars: CheMin X‐ray diffraction of the Windjana sample (Kimberley area, Gale Crater)

    Science.gov (United States)

    Bish, David L.; Vaniman, David T.; Chipera, Steve J.; Blake, David F.; Ming, Doug W.; Morris, Richard V.; Bristow, Thomas F.; Morrison, Shaunna M.; Baker, Michael B.; Rampe, Elizabeth B.; Downs, Robert T.; Filiberto, Justin; Glazner, Allen F.; Gellert, Ralf; Thompson, Lucy M.; Schmidt, Mariek E.; Le Deit, Laetitia; Wiens, Roger C.; McAdam, Amy C.; Achilles, Cherie N.; Edgett, Kenneth S.; Farmer, Jack D.; Fendrich, Kim V.; Grotzinger, John P.; Gupta, Sanjeev; Morookian, John Michael; Newcombe, Megan E.; Rice, Melissa S.; Spray, John G.; Stolper, Edward M.; Sumner, Dawn Y.; Vasavada, Ashwin R.; Yen, Albert S.

    2016-01-01

    Abstract The Windjana drill sample, a sandstone of the Dillinger member (Kimberley formation, Gale Crater, Mars), was analyzed by CheMin X‐ray diffraction (XRD) in the MSL Curiosity rover. From Rietveld refinements of its XRD pattern, Windjana contains the following: sanidine (21% weight, ~Or95); augite (20%); magnetite (12%); pigeonite; olivine; plagioclase; amorphous and smectitic material (~25%); and percent levels of others including ilmenite, fluorapatite, and bassanite. From mass balance on the Alpha Proton X‐ray Spectrometer (APXS) chemical analysis, the amorphous material is Fe rich with nearly no other cations—like ferrihydrite. The Windjana sample shows little alteration and was likely cemented by its magnetite and ferrihydrite. From ChemCam Laser‐Induced Breakdown Spectrometer (LIBS) chemical analyses, Windjana is representative of the Dillinger and Mount Remarkable members of the Kimberley formation. LIBS data suggest that the Kimberley sediments include at least three chemical components. The most K‐rich targets have 5.6% K2O, ~1.8 times that of Windjana, implying a sediment component with >40% sanidine, e.g., a trachyte. A second component is rich in mafic minerals, with little feldspar (like a shergottite). A third component is richer in plagioclase and in Na2O, and is likely to be basaltic. The K‐rich sediment component is consistent with APXS and ChemCam observations of K‐rich rocks elsewhere in Gale Crater. The source of this sediment component was likely volcanic. The presence of sediment from many igneous sources, in concert with Curiosity's identifications of other igneous materials (e.g., mugearite), implies that the northern rim of Gale Crater exposes a diverse igneous complex, at least as diverse as that found in similar‐age terranes on Earth. PMID:27134806

  17. Mineralogy, provenance, and diagenesis of a potassic basaltic sandstone on Mars: CheMin X-ray diffraction of the Windjana sample (Kimberley area, Gale Crater)

    Science.gov (United States)

    Treiman, Allan H.; Bish, David L.; Vaniman, David T.; Chipera, Steve J.; Blake, David F.; Ming, Doug W.; Morris, Richard V.; Bristow, Thomas F.; Morrison, Shaunna M.; Baker, Michael B.; Rampe, Elizabeth B.; Downs, Robert T.; Filiberto, Justin; Glazner, Allen F.; Gellert, Ralf; Thompson, Lucy M.; Schmidt, Mariek E.; Le Deit, Laetitia; Wiens, Roger C.; McAdam, Amy C.; Achilles, Cherie N.; Edgett, Kenneth S.; Farmer, Jack D.; Fendrich, Kim V.; Grotzinger, John P.; Gupta, Sanjeev; Morookian, John Michael; Newcombe, Megan E.; Rice, Melissa S.; Spray, John G.; Stolper, Edward M.; Sumner, Dawn Y.; Vasavada, Ashwin R.; Yen, Albert S.

    2016-01-01

    The Windjana drill sample, a sandstone of the Dillinger member (Kimberley formation, Gale Crater, Mars), was analyzed by CheMin X-ray diffraction (XRD) in the MSL Curiosity rover. From Rietveld refinements of its XRD pattern, Windjana contains the following: sanidine (21% weight, ~Or95); augite (20%); magnetite (12%); pigeonite; olivine; plagioclase; amorphous and smectitic material (~25%); and percent levels of others including ilmenite, fluorapatite, and bassanite. From mass balance on the Alpha Proton X-ray Spectrometer (APXS) chemical analysis, the amorphous material is Fe rich with nearly no other cations—like ferrihydrite. The Windjana sample shows little alteration and was likely cemented by its magnetite and ferrihydrite. From ChemCam Laser-Induced Breakdown Spectrometer (LIBS) chemical analyses, Windjana is representative of the Dillinger and Mount Remarkable members of the Kimberley formation. LIBS data suggest that the Kimberley sediments include at least three chemical components. The most K-rich targets have 5.6% K2O, ~1.8 times that of Windjana, implying a sediment component with >40% sanidine, e.g., a trachyte. A second component is rich in mafic minerals, with little feldspar (like a shergottite). A third component is richer in plagioclase and in Na2O, and is likely to be basaltic. The K-rich sediment component is consistent with APXS and ChemCam observations of K-rich rocks elsewhere in Gale Crater. The source of this sediment component was likely volcanic. The presence of sediment from many igneous sources, in concert with Curiosity's identifications of other igneous materials (e.g., mugearite), implies that the northern rim of Gale Crater exposes a diverse igneous complex, at least as diverse as that found in similar-age terranes on Earth.

  18. Modulation of pancreatic MIN6 insulin secretion and proliferation and extrapancreatic glucose absorption with Achillea santolina, Eryngium creticum and Pistacia atlantica extracts: in vitro evaluation

    Directory of Open Access Journals (Sweden)

    Lara Majdalawi

    2012-06-01

    Full Text Available Objective: The present in vitro studies aimed to investigate the pancreatic and extrapancreatic effects of crude aqueous extracts (AE of Achillea santolina L, Eryngium creticum Lam, and Pistacia atlantica Desf utilized in Jordan diabetes ethnomedicine. Methods: Bioassays of β-cell proliferation and insulin secretion as well as glucose diffusion as possible modes of action were recruited. Results: Similar to L-alanine insulinotropic efficacy in MIN6 β-cell, glucose-stimulated Ca2+ regulated- insulin secretion was potentiated by AEs of E.creticum (0.01 mg/ml and P.atlantica (0.01, 0.1 and 0.5 mg/ml. A.santolina AE, however, was found ineffective. Comparable to glucagon-like peptid-1-enhanced β-cell proliferation in 2-day treatment wells, a dose dependent augmentation of bromodeoxyuridine incorporation was obtained with the A.santolina AE (0.05-1 mg/ml, and E.creticum AE (0.1, 0.5 and 1 mg/ml. P.atlantica concentrations lacked pancreatic proliferative capacity. While A.santolina and E.creticum AEs proved inactive, P.atlantica inhibited dose dependently overnight glucose movement in vitro, as effectively as guar gum diffusional hindrance in a simple glucose dialysis model. Conclusion: Current findings signify the in vitro diverse therapeutic antidiabetes properties of the selected medicinal plants. Future directives may assess the use of A.santolina, E.creticum and P.atlantica as new potential sources of functional foods or nutraceuticals or active leads into diabetes type 2 pharmacotherapy. [J Exp Integr Med 2012; 2(3.000: 245-254

  19. Factors regulating community composition of methanogens and sulfate-reducing bacteria in brackish marsh sediments in the Min River estuary, southeastern China

    Science.gov (United States)

    She, C. X.; Zhang, Z. C.; Cadillo-Quiroz, H.; Tong, C.

    2016-11-01

    Assessing the diverse communities of methanogenic Archaea and sulfate-reducing bacteria (SRB) is important to understand methane (CH4) production in wetland ecosystems. However, the vertical distribution of composition and diversity, and the effects of environmental factors on the methanogen and SRB communities in the sediments of subtropical estuarine brackish marshes have been poorly characterized. To assess the effects of variable environmental conditions on methanogenic and SRB communities in marshes, we studied three brackish marsh zones dominated by Phragmites australis, Cyperus malaccensis and Spartina alterniflora, respectively, in the Min River estuary, southeastern China. Methanogens of the Methanomicrobiales order was the dominant group at sediment depths of 0-30 cm, which indicated that the main pathway of methane production was H2/CO2 in this zone. In general, methanogens of the genus Methanoregula were dominant in the three marsh zones. For SRB, Desulfobacterales was the dominant group, and Desulfobacterium and Desulfosarcina were the predominant genera at the depth of 0-30 cm. The community composition of methanogens and SRB changed with vegetation type and soil depth. Compared with SRB, vegetation type demonstrated a stronger influence on the community composition of methanogens. Canonical correspondence analysis (CCA) analysis further revealed that the main factors affecting the methanogens community composition were EC (electric conductivity) and pH, and the main factors affecting SRB community composition were pH, SOC and TN, suggesting that pH is a common factor influencing the community compositions of both methanogen and SRB in the sediments of brackish marshes.

  20. Hémophagocytose et coagulation intravasculaire disséminée au cours de la leishmaniose viscérale de l'adulte: trois nouveaux cas

    Science.gov (United States)

    Boukhris, Imène; Azzabi, Samira; Chérif, Eya; Kéchaou, Ines; Mahjoub, Sonia; Kooli, Chékib; Aoun, Karim; Khalfallah, Narjes

    2015-01-01

    Les atteintes cliniques et biologiques communes au syndrome d'activation macrophagique (SAM) et à la leishmaniose viscérale (LV) rendent le diagnostic étiologique du SAM très difficile. Cette association est rare et grave. Nous rapportons trois nouvelles observations de SAM secondaire à une LV, compliquées de coagulation intravasculaire disséminée (CIVD). Il s'agissait de trois hommes, âgés respectivement de 31, 20 et 60 ans. Le tableau était fait de fièvre et de splénomégalie associés à une pancytopénie et une CIVD. Le diagnostic de LV était fait par le myélogramme, les sérologies et la polymerase chain reaction. Chez l'un de nos patients, une deuxième sérologie était nécessaire. Tous nos patients étaient traités par Glucantime® avec une bonne évolution. Un cas de pancréatite aigue était noté. En en zones d'endémie, devant un SAM compliqué de CIVD, une LV doit être recherchée, en répétant si nécessaire certaines explorations initialement négatives. Le pronostic dépend de la rapidité du traitement spécifique. PMID:26848343

  1. 具有寿命估算的最大-最小蚂蚁系统%Improved max-min ant system with lifetime estimation

    Institute of Scientific and Technical Information of China (English)

    姚金涛; 祝胜林; 孔宇彦

    2011-01-01

    提出了一种具有寿命估算的最大-最小蚂蚁系统,该算法对进化种群数进行宏观调控的同时,用个体寿命限制个体的生存期,利用蚂蚁能估算自己所剩寿命的能力,实现其突变性的大风险搜索行为,从而扩大搜索范围,即主动性增加蚁群多样性,使蚁群逃离局部最优,并为实现蚁群的快速收敛提供可能.通过对TSP问题的仿真实验结果表明,该方法能够有效防止早熟收敛,较好地平衡局部搜索和全局搜索的收敛性能.%This paper proposes a variant of ACO called Max-Min Ant System with Lifetime Estimation (MMAS_LE). MMASLE uses both macroscopical control and microcosmic control based on lifetime estimating of ants to realize mutation-al and risky search behavior,which can broaden the search space,break local convergence and speed the global convergence by increasing the population diversity actively.The simulation results on TSP problem show that MMASLE can efficiently avoid premature convergence and well balance the exploration and exploitation.

  2. Beat Tracking Based on Max-Min Distance Means%基于最大最小距离法的节拍跟踪

    Institute of Scientific and Technical Information of China (English)

    李锵; 何凝; 关欣

    2015-01-01

    将端点检测与聚类算法结合,提出一种基于最大最小距离法的节拍跟踪算法.首先,将音乐信号分解成多个频率互不重叠的子带进行频谱分析,分别利用半波整流,求和得到最终的端点强度曲线.其后,根据能量谱找到起始节拍点.最后,根据最大最小距离法并利用音乐速度与节拍的关系,对端点强度曲线峰值进行有效聚类,识别出节拍点.实验结果表明,该算法识别节拍点准确有效,4评估指标 P-score、Cemgil、CMLc 和 AMLt 分别达到57.355,10、38.705,37、17.152,40和47.259,12,与其他算法相比综合性能较好.%In this paper,combining onset detection and clustering algorithm,a novelbeat tracking algorithm based on max-min distance(MMD) means was proposed. First,the spectrum of music signal was decomposed into several non-overlapping sub-bands. Second,by utilizing the half-wave rectifier on these sub-bands respectively,the final onset strength curve was found. Then,the first beat was discovered based on the energy spectrum of the starting point. Finally,based on MMDmeans,the beats of the music signal were identified according to the relationship between music tempo and beat,together with effective clustering of curve peaks of onset strength. Experimental re-sults proved that the proposed algorithm can track beats accurately. The four evaluation indicators of the algorithm P-score,Cemgil,CMLc and AMLt,reached 57.355,10,38.705,37,17.152,40 and 47.259,12,respectively. Com-pared with other algorithms,the proposed algorithm possesses better comprehensive performance.

  3. Cloning and sequencing of the gD gene of pseudorabies virus Min-A strain%伪狂犬病病毒Min-A株gD基因的克隆及其真核表达质粒的构建

    Institute of Scientific and Technical Information of China (English)

    胡涛; 崔保安; 王岩; 祁小乐; 王丽娟

    2004-01-01

    参考GeneBank收录的伪狂犬病病毒gD基因的序列设计了一对引物,对PRV Min-A株进行了PCR扩增,扩增产物克隆于pGEM-T Easy载体.对重组质粒PGTE-gD进行限制性内切酶分析和基因测序,证实了克隆片段的可靠性.测序结果表明目的片段包含一个1203bp的开放性阅读框(ORF),编码400个氨基酸组成的多肽.将gD基因亚克隆至真核表达载体pcDVA3.1-的CMV启动子下游,构建了真核表达质粒pcDNA-gD,为下一步基因免疫奠定了基础.

  4. La découverte du dioxyde de carbone dans les inclusions des minéraux : une grande aventure scientifique du dix-neuvième siècle

    OpenAIRE

    Touret, Jacques

    1999-01-01

    International audience La fin du XVIIIe siècle a vu la naissance de la minéralogie moderne, dans une période féconde en découvertes où s'affrontaient les écoles suédoise(Berzelius et Torbern Bergman), allemande (Werner) et française (Romé de l'Isle et René-Just Haüy). Ce seront les Français qui, grâce au Traité de Minéralogie de René Just Haüy, feront la meilleure synthèse de tous ces travaux et resteront, pour la postérité, les inventeurs de la cristallographie et de la minéralogie telles...

  5. ℤmin上秩-1矩阵的周长不等式及线性保持算子%Perimeter Inequality and Linear-Preserving Operators of Rank-1 Matrices over ℤmin

    Institute of Scientific and Technical Information of China (English)

    张廷海; 邓中书

    2015-01-01

    利用 Boolean 秩-1矩阵的周长保持性质和 Boolean 代数 B 与ℤ min 上矩阵之间支配关系的等价性获得了ℤ min上秩-1矩阵和的周长所满足的不等式,保持其秩与周长的线性算子以及保持秩-1和周长2的性质。%Based on the preserving properties of the perimeter of Boolean rank-1 matrices and the equivalence of the dominating relation between matrices over Boolean algebra B and ℤ min , the inequality on the perimeter of the sum of two rank-1 matrices over ℤ min and the linear operator of preserving the rank and perimeter.At last it get the properties of preserving the rank and perimeter 2 of rank-1 matrices over ℤ min .

  6. Effect of maternal and post weaning folate supply on gene-specific DNA methylation in the small intestine of weaning and adult Apc+/Min and wild type mice.

    Directory of Open Access Journals (Sweden)

    Jill Ann Mckay

    2011-05-01

    Full Text Available Increasing evidence supports the developmental origins of adult health and disease hypothesis which argues for a causal relationship between adverse early life nutrition and increased disease risk in adulthood. Modulation of epigenetic marks, e.g. DNA methylation and consequential altered gene expression, has been proposed as a mechanism mediating these effects. Via its role as a methyl donor, dietary folate supply may influence DNA methylation. As aberrant methylation is an early event in colorectal cancer (CRC pathogenesis, we hypothesised low maternal and/or post-weaning folate intake may influence methylation of genes involved in CRC development. We investigated the effects of maternal folate depletion during pregnancy and lactation on selected gene methylation in the small intestine (SI of wild type (WT and Apc+/Min mice at weaning and as adults. We also investigated the effects of folate depletion post-weaning on gene methylation in adult mice. Female C57Bl6/J mice were fed low or normal folate diets from mating with Apc+/Min males to the end of lactation. A sub set of offspring were killed at weaning. Remaining offspring were weaned on to low or normal folate diets, resulting in 4 treatment groups of Apc+/Min and WT mice. p53 was more methylated in weaning and adult WT compared with Apc+/Min mice (p>0.001. Igf2 and Apc were hypermethylated in adult Apc+/Mi n compared with WT mice (p=0.004 & p=0.012 respectively. Low maternal folate reduced p53 methylation in adults (p=0.04. Low post-weaning folate increased Apc methylation in Apc+/Min mice only (p=0.008 for interaction. These observations demonstrate that folate depletion in early life can alter epigenetic marks in a gene specific manner. Also, the differential effects of altered folate supply on DNA methylation in WT and Apc+/Min mice suggest that genotype may modulate epigenetic responses to environmental cues and may have implications for the development of personalised nutrition.

  7. Association of Pulse Pressure, Arterial Elasticity, and Endothelial Function With Kidney Function Decline Among Adults With Estimated GFR > 60 mL/min/1.73 m2: The Multi-Ethnic Study of Atherosclerosis

    Science.gov (United States)

    Peralta, Carmen A.; Jacobs, David R.; Katz, Ronit; Ix, Joachim H.; Madero, Magdalena; Duprez, Daniel A.; Sarnak, Mark J.; Criqui, Michael H.; Kramer, Holly J.; Palmas, Walter; Herrington, David; Shlipak, Michael G.

    2011-01-01

    Background The association of subclinical vascular disease and early declines in kidney function has not been well studied. Study Design Prospective cohort study Setting & Participants MESA participants with eGFR ≥60 ml/min/1.73m2 with follow-up of 5 years Predictors Pulse pressure (pulse pressure), small and large arterial elasticity (SAE, LAE), and flow mediated dilation. Outcomes kidney function decline Measurements SAE and LAE were measured by pulse contour analysis of the radial artery. Kidney function was measured by serum creatinine- and cystatin C-based eGFR. Results Among 4,853 adults, higher pulse pressure and lower SAE and LAE had independent and linear associations with faster rates of kidney function decline. Compared to persons with pulse pressure 40–50mmHg, eGFRSCysC decline was 0.29 (p=0.006), 0.56 (p70mmHg, respectively. Compared to the highest quartile of SAE (most elastic), eGFRSCysC decline was 0.26 (p=0.009), 0.35 (p=0.001), and 0.70 (p<0.001) ml/min/1.73m2/year faster for the second, third and fourth quartiles respectively. For LAE, compared to the highest quartile, eGFRSCysC decline was 0.28 (p=0.004), 0.58 (p<0.001), and 0.83 (p<0.001) ml/min/1.73m2/year faster for each decreasing quartile of LAE. Findings were similar with creatinine-based eGFR. In contrast, among 2,997 adults with flow-mediated dilation and kidney function measures, flow-mediated dilation was not significantly associated with kidney function decline. For every 1-SD greater flow-mediated dilation, eGFRSCysC and eGFRSCr changed by 0.05 ml/min/1.73m2/year (p=0.3) and 0.06 ml/min/1.73m2/year (p=0.04), respectively. Limitations We had no direct measure of GFR, in common with nearly all large population based studies. Conclusions Higher pulse pressure and lower arterial elasticity, but not flow-mediated dilation, were linearly and independently associated with faster kidney function decline among persons with eGFR ≥60 ml/min/1.73m2. Future studies investigate whether

  8. Hvorfra min verden går

    DEFF Research Database (Denmark)

    Keiding, Tina Bering

    kendes eksempelvis fra koblingen mellem funktionssystemer som eksem-pelvis uddannelsessystemet og det økonomiske system, og som tidligere nævnt mellem det videnskabelige system og uddannelsessystemet. Det er dog ikke alle typer gensidige iagttagelser mellem sociale systemer, der inkluderes i kategorien...... ’strukturelle koblinger’. En uddannelses kommunikationsbidrag i form af studie-planer, arbejdsplaner, lokaletildelinger mv. kan iagttages og genindtræde i under-visningen og dermed bidrage til dens bestemmelse af sig selv. Her er dog ikke tale om en kobling mellem funktionssystemer, men om at uddannelsens...... meddelelser forstås af undervisningen og dennes deltagere, altså om asynkron kommunikation bestående af et kommunikationselement. En del af uddannelsens meddelte information vil almindeligvis have karakter af ’interventionskommunikation’, forstået som kommunikation, der ønsker at speci-ficere delsystemer i...

  9. Max–min distance nonnegative matrix factorization

    KAUST Repository

    Wang, Jim Jing-Yan

    2014-10-26

    Nonnegative Matrix Factorization (NMF) has been a popular representation method for pattern classification problems. It tries to decompose a nonnegative matrix of data samples as the product of a nonnegative basis matrix and a nonnegative coefficient matrix. The columns of the coefficient matrix can be used as new representations of these data samples. However, traditional NMF methods ignore class labels of the data samples. In this paper, we propose a novel supervised NMF algorithm to improve the discriminative ability of the new representation by using the class labels. Using the class labels, we separate all the data sample pairs into within-class pairs and between-class pairs. To improve the discriminative ability of the new NMF representations, we propose to minimize the maximum distance of the within-class pairs in the new NMF space, and meanwhile to maximize the minimum distance of the between-class pairs. With this criterion, we construct an objective function and optimize it with regard to basis and coefficient matrices, and slack variables alternatively, resulting in an iterative algorithm. The proposed algorithm is evaluated on three pattern classification problems and experiment results show that it outperforms the state-of-the-art supervised NMF methods.

  10. MInD: moving in the dark.

    Science.gov (United States)

    Pepino, A; Sicignano, G; Rovani, M; D'Addio, G

    2012-01-01

    Visually-impaired people can develop several unhealthy behaviors, including the lack of physical activity or sports, due to the incomplete maturity in the control of their body in the space. This research focuses on the creation of an "exergame" - a videogame especially designed to stimulate physical exercise - that, through voice commands, allows the visually impaired users to practice physical activity and train their abilities. This tool has been developed starting from an existing dance-game, by generating some appropriate interfaces that also involve the sensory channel of sight. Our research aims to study the effects related to this exergame on the motor control mechanism in a blind children's group, aged between 8 and 13 years: it focuses also on the joint use of movement analysis systems and of videogames in order to stimulate the physical activity in these subjects. PMID:22874404

  11. Dersom Du, min Læser! ..

    DEFF Research Database (Denmark)

    Wille, Niels Erik

    2011-01-01

    Diskuterer problemer med anvendelse af sproghandlingsteori på illokutionære (især assertive) sproghandlinger i fiktionsfortællinger og andre tekster. Påviser at problemerne udspringer af uheldige eller ugennemtænkte formuleringer allerede i de første formuleringer af sproghandlingsteorien samt dens...

  12. 3min. poster presentations of B01

    Science.gov (United States)

    Foing, Bernard H.

    We give a report on recommendations from ILEWG International conferences held at Cape Canaveral in 2008 (ICEUM10), and in Beijing in May 2010 with IAF (GLUC -ICEUM11). We discuss the different rationale for Moon exploration. Priorities for scientific investigations include: clues on the formation and evolution of rocky planets, accretion and bombardment in the inner solar system, comparative planetology processes (tectonic, volcanic, impact cratering, volatile delivery), historical records, astrobiology, survival of organics; past, present and future life. The ILEWG technology task group set priorities for the advancement of instrumenta-tion: Remote sensing miniaturised instruments; Surface geophysical and geochemistry package; Instrument deployment and robotic arm, nano-rover, sampling, drilling; Sample finder and collector. Regional mobility rover; Autonomy and Navigation; Artificially intelligent robots, Complex systems. The ILEWG ExogeoLab pilot project was developed as support for instru-ments, landers, rovers,and preparation for cooperative robotic village. The ILEWG lunar base task group looked at minimal design concepts, technologies in robotic and human exploration with Tele control, telepresence, virtual reality; Man-Machine interface and performances. The ILEWG ExoHab pilot project has been started with support from agencies and partners. We discuss ILEWG terrestrial Moon-Mars campaigns for validation of technologies, research and human operations. We indicate how Moon-Mars Exploration can inspire solutions to global Earth sustained development: In-Situ Utilisation of resources; Establishment of permanent robotic infrastructures, Environmental protection aspects; Life sciences laboratories; Support to human exploration. Co-Authors: ILEWG Task Groups on: Science, Technology, Robotic village, Lunar Bases , Commercial and Societal aspects, Roadmap synergies with other programmes, Public en-gagemnet and Outreach, Young Lunar Explorers.

  13. Étude de la composition minérale et organique des liqueurs de thé et de leurs caractéristiques organoleptiques : influence des paramètres physico-chimiques de l'eau

    OpenAIRE

    Mossion, Aurélie

    2007-01-01

    L'analyse de la composition organique et minérale d'infusions réalisées avec différentes variétés de thés et différentes eaux a permis de montrer que la physico-chimie de l'eau (composition, pH, température) contrôle l'extraction des composés présents dans les feuilles et les propriétés organoleptiques des liqueurs obtenues. Le calcium, en particulier, présent sous forme libre, diminue l'extraction des éléments minéraux, des polyphénols et de la caféine du fait de sa grande affinité pour les ...

  14. Research on extended min-sum decoding algorithm of nonbinary low density parity check codes%多进制低密度奇偶校验码的扩展最小和译码算法研究

    Institute of Scientific and Technical Information of China (English)

    庞臣; 徐家品

    2014-01-01

    This paper mainly reviews several commonly used decoding algorithm of nonbinary LDPC codes, highlight analyzes the extended min-sum algorithms, and proves its superiority with the use of contrast.%综述了多进制 LDPC 码的几种常用译码算法,重点讲解分析了其中的扩展最小和算法,并采用对比的方法证明其优越性。

  15. 骨形态发生蛋白7对胰岛素分泌的影响及机制研究%Bone morphorgenetic protein 7 improves insulin secretion from mouse pancreatic beta cell line MIN6

    Institute of Scientific and Technical Information of China (English)

    姜友昭; 曾俊; 陈兵

    2012-01-01

    Objective To determine the effect of bone morphorgenetic protein 7 ( BMP7) on insulin secretion in pancreatic beta cells. Methods The expression of three type I receptors of BMP7 , BMPR1 A, BMPR1B and ACVR1A, was detected by Western blotting in mouse pancreatic beta cell line MIN6. Then the MIN6 cells were treated respectively by PBS (control), low-, medium- and high-dose of rhBMP7 (final concentration of rhBMP7 was 10, 50, and 100 ng/ml). Then the insulin level of the culture media was detected by ELISA and the intracellular concentration of calcium was determined by laser confocal microscopy. Results BMPR1A, BMPR1B and ACVR1A were all expressed in the MIN6 cells. The insulin concentration of PBS, low-, medium- and high-dose rhBMP7 treatment was 0.42 ±0. 11, 0.63 ±0.22, 0.82+0.0.19 and 1.24 ±0. 26 ng/(ml ·μxg) , respectively. The insulin concentration of rhBMP7 treatment groups was significantly higher than that of the control (all P 0. 05). Conclusion BMP7 enhances insulin secretion significantly in pancreatic beta cells, which may be due to its regulation of calcium-independent exocytosis.%目的 探讨骨形态发生蛋白7(bone morphorgenetic protein 7,BMP7)对胰岛细胞胰岛素分泌的影响.方法 Westem blot检测小鼠胰岛细胞株MIN6中3种BMP7的Ⅰ型受体BMPR1A、BMPR 1B、ACVR1A的表达情况.将MIN6细胞分为4组:PBS对照组,重组人BMP7( rhBMP7)低、中、高剂量组(rhBMP7终浓度分别为10、50、100 ng/ml),每组设5个复孔.ELISA检测各组细胞培养基中的胰岛素分泌情况.激光共聚焦显微镜检测细胞内钙离子浓度变化.结果 BMPR1A、BMPR1B、ACVR1A均表达于MIN6细胞.PBS对照组及rhBMP7低、中、高剂量组的胰岛素浓度分别为(0.42±0.11)、(0.63±0.22)、(0.82±0.19)、( 1.24 -±0.26) ng/(ml· μg).与对照组相比,rhBMP7低、中、高剂量组的胰岛素分泌均明显增加(P<0.05).PBS对照组及rhBMP7低、中、高剂量组的细胞内钙离子浓度增加分别为(3.5

  16. 杨惠民教授治疗老年类风湿关节炎经验%Experience of Therapy Elderly Rheumatoid Arthritis by Professor YANG Hui-min

    Institute of Scientific and Technical Information of China (English)

    姜洋

    2012-01-01

    Introducing the therapy experience of elderly rheumatoid arthritis hy Professor YANG Hui-min, summarizing the pathogenic factors and pathogenesis of rheumatoid arthritis, dividing elderly rheumatoid into activity and stability of treatment.%介绍杨惠民教授治疗老年类风湿关节炎经验,总结老年类风湿关节炎的病因病机,将老年类风湿关节炎分活动期与稳定期进行治疗.

  17. Evaluation of Ecosystem Services of Min River Estuary Wetland Nature Reserve%闽江河口湿地自然保护区生态系统服务价值评价

    Institute of Scientific and Technical Information of China (English)

    傅娇艳

    2012-01-01

    According to the theories of ecological economics and resource economics, a comprehensive evaluation of ecosystem services of Min River Estuary Wetland Nature Reserve was carried out based on existing survey data in order to protect the wetland and provide a scientific basis for public decision-making. The Ecosystem service value of Min River Estuary Wetland Nature Reserve was estimated at RMB 4966.l×104. The components of the ecosystem services were ranked on their values as: climate regulation> cultural carrier> biodiversity conservation>provision of goods.%研究运用生态经济学和资源环境经济学等有关理论和研究方法,利用前人已有调查资料,对闽江河口湿地自然保护区生态系统服务价值做了较全面的评价,拟为保护湿地和公共决策提供科学依据.闽江河口湿地自然保护区生态系统服务价值为4 966.1万元/a.按照价值量大小排序为:调节气候价值>文化载体价值>保护生物多样性价值>提供产品价值.

  18. Contribution of Fragmentary Argumentation of Qi Min Yao Shu to the Construction of Accounting Culture%《齐民要术・杂说》对会计文化建设的贡献

    Institute of Scientific and Technical Information of China (English)

    2013-01-01

    Qi Min Yao Shu written by Jia Sixie has made great contributions to accounting culture , including:improving the efficiency of using fixed assets , decision predicting, taking field trips, dealing with different lands in different ways, adjusting the market, improving effectiveness and so on.The contribution of Qi Min Yao Shu to the construction of Chinese accounting culture lies in that it teaches a lesson of how to make use of "assets"reasonably and effectively.%  贾思勰《齐民要术・杂说》对会计文化的贡献很多,包括提高利用固定资产效率、预测决策、实地考察、区别对待、调节市场、提高效益等思想,其对中国会计文化建设的核心贡献就在于合理有效运用“资产”。

  19. Contribution of Fragmentary Argumentation of Qi Min Yao Shu to the Construction of Accounting Culture%《齐民要术・杂说》对会计文化建设的贡献

    Institute of Scientific and Technical Information of China (English)

    2013-01-01

      贾思勰《齐民要术・杂说》对会计文化的贡献很多,包括提高利用固定资产效率、预测决策、实地考察、区别对待、调节市场、提高效益等思想,其对中国会计文化建设的核心贡献就在于合理有效运用“资产”。%Qi Min Yao Shu written by Jia Sixie has made great contributions to accounting culture , including:improving the efficiency of using fixed assets , decision predicting, taking field trips, dealing with different lands in different ways, adjusting the market, improving effectiveness and so on.The contribution of Qi Min Yao Shu to the construction of Chinese accounting culture lies in that it teaches a lesson of how to make use of "assets"reasonably and effectively.

  20. Heavy Metals Pollution and It's Assessment in the Wetlands of Min River Estuary in Fujian Province%福建闽江河口湿地土壤重金属污染特征及评价研究

    Institute of Scientific and Technical Information of China (English)

    侯晓龙; 黄建国; 刘爱琴

    2009-01-01

    The pollution characteristics of heavy metal in the estuary wetland of Min River in Fujian Province was thoroughly investigated and the contents of Cu, Pb, Zn, Cd, Mn, Ni and Cr from 8 monitoring sites were analyzed. And then the heavy metal pollution in the estuary wetland of Min River was evaluated by the method of N. L. Nemerow Comprehensive Pollution Index and Geoaccumulation Index. The results showed that the heavy metal pollution was serious in the estuary wetland of Min River. The contents of Cu, Pb, Zn, Cd and Mn exceeded the Standard of China National Soil Environment Quality Standard (level I) except Ni and Cr. The Single Pollution Index Assessment showed that the estuary wetland of Min River exist Cu, Pb, Zn, Cd and Mn pollution in different extents and no Ni and Cr pollution. The pollution degree of different heavy metals was in sequence of Pb>Cu>Zn>Cd. The Comprehensive Pollution Index Assessment showed that Tan-tou-gang and Shan-yu-tan existed slight pollution and the other monitoring sites were belonged to moderate pollution, which indicated there was serious comprehensive pollution in the estuary wetland of Min River. The Ceoaccumulation Index Assessment showed that the Pb, Zn and Cd were belong to moderate or slight polution level, and there were no Cu, Mn, Ni and Cr pollution.%为掌握福建闽江河口湿地重金属污染特征,对闽江河口湿地不同监测点重金属污染状况进行全面调查采样,利用综合污染指数法和地累积指数法对重金属污染状况进行评价.结果表明,福建闽江河口湿地重金属污染比较严重,除Ni和Cr外,Cu、Pb、Zn、Cd、Mn均超过土壤环境质量标准(I级).除Ni和Cr单项污染指数无污染外,其他监测点均有不同程度的重金属污染,污染程度表现为Pb>Cu>Zn>Cd;综合污染指数除潭头港和鳝鱼滩为轻度污染,其他6个监测点均达到中度污染以上,表明闽江河口湿地存在严重的重金属复合污染.地累积指数除Pb、Zn

  1. 网络最小费用最大流双目标遗传优化算法%Bi-objective optimization of network min-cost and max-flow based on genetic algorithm

    Institute of Scientific and Technical Information of China (English)

    厍向阳

    2011-01-01

    针对将网络最小费用最大流问题转化为单目标优化问题进行求解的缺陷,提出网络最小费用最大流的双目标优化模型,并引入多目标遗传算法.对最小支撑树对应的余树弦流量初始值进行编码,通过解码和回路矩阵计算流量网络树枝的流量.在网络最小费用、最大流量双目标函数和网络结点容量、网络分支容量约束条件基础上,按照多目标优化理论构建增广最小化双目标函数,依此对网络流量方案编码进行评价.使用进化算子对网络流量方案编码实施进化操作,最后通过迭代得到满意解.以矿井通风网络为例进行了测试.结果表明:网络最小费用最大流双目标遗传算法是完全可行和有效的.该算法减少了最优化模型中变量数目、提高了运算效率.%Aimed at the defect of transfering network min-cost and max-flow to single objective optimization, the bi-objective optimization model of network min-cost and max-flow was proposed, and multi-objective genetic algorithm was adopted. The flow values of remain branches were encoded and initialized by multi-objective genetic algorithm, and the flow values of tree branches were calculated by decoding and circuit matrix. Based on network min-cost and max-flow function, nodes capacity and branches capacity restrictions, the generalized bi-objective function were set up according to multi-objective optimization theory. The flow scheme codes were evaluated by the generalized bi-objective function and evolved by evolution arithmetic operators to obtain optimization min-cost and max-flow schemes by iterative algorithm. Mine ventilation network was taken as example to conduct the test. The results show that the biobjective genetic algorithm of network min-cost and max-flow is feasible and effective. The variable number is reduced in this algorithm and algorithm efficiency is improved.

  2. A pioneer in the frontier of engineering science——Zhe-Min Zheng%工程科学前沿的拓荒者——郑哲敏

    Institute of Scientific and Technical Information of China (English)

    戴兰宏

    2013-01-01

    Zhe-Min Zheng,as a famous mechanician,is the founder and pioneer of explosion mechanics in China.He won the State Preeminent Science and Technology Award of China in 2012.This paper reviews the abundant research activities of Zhe-Min Zheng over the past 60 years,especially his outstanding academic contributions in the areas of explosion processing,underground nuclear explosion,blasting push-out silt,armor penetration by shaped charge jet,coal and gas outburst,natural gas hydrate mining,hydro-elastic dynamics,material mechanical behavior,etc.These achievements are marked by distinct character of engineering science,that is,they are motivated from the national significant demands,and reached by refining the critical physical factors and innovative theories from complex issues,and providing useful guide to practice.The scientific contributions and academic thoughts of Zhe-Min Zheng have great practical significance and reference value for the development of mechanics.%郑哲敏先生是著名力学家,我国爆炸力学的奠基人和开拓者,2012年度国家最高科学技术奖获得者.本文回顾了郑哲敏先生在过去60多年中非常丰富的科研活动,特别是他在爆炸加工、地下核爆、爆炸排淤、穿破甲、煤与瓦斯突出、水合物开采、水弹性动力学、材料力学行为等方面的杰出学术贡献.这些工作闪耀着鲜明的工程科学特点,即着眼国家重大需求,从错综复杂的问题中概括提炼关键物理因素,创新理论,进而指导实践.郑哲敏先生的科学贡献和学术思想,对于力学学科发展,有着重要的现实意义和参考价值.

  3. Aplicação de emulsões na flotação do minério de zinco Use of emulsions in zinc ore flotation

    Directory of Open Access Journals (Sweden)

    Tiago Alvarenga Vitorino da Silva

    2008-03-01

    Full Text Available Várias linhas de flotação de minérios oxidados de zinco já foram estudadas e, segundo a maioria dos pesquisadores, a flotação catiônica com altas concentrações de sulfeto de sódio, usando amina primária como coletor, tem sido a opção mais adequada para concentrar esses minérios. Nesse trabalho, investigou-se a aplicação de novos sistemas de reagentes para flotar o minério de zinco com willemita, em etapas de depressão de gangas, dispersão, sulfetização e flotação do zinco. Os testes de flotação, usando emulsão de amina com óleos vegetais e diesel, mostraram que a amina emulsificada apresentou um desempenho na flotação superior à amina não emulsificada, além de permitir uma redução significativa de sulfeto de sódio. Dos óleos vegetais estudados destacaram-se a mamona e o coco-babaçu, porém os resultados de recuperação foram inferiores ao óleo diesel.Several approaches to the flotation of oxidized zinc ores were already studied, and according to most of the researchers, the cationic flotation with high concentrations of sodium sulfide, using primary amine as collector, has been the most appropriate option to concentrate this type of ore. In this work, the application of innovative systems of reagents to float willemite was investigated, including the stages of gangue depression, dispersion, sulfidization and zinc flotation. The flotation tests using amine emulsion with vegetable oils and diesel oil showed that the amine emulsion yielded a better flotation performance than that of amine without emulsion, besides allowing a significant reduction of sodium sulfide dosage. Among the vegetable oils studied castor and babaçu coconut oils yielded reasonable results, despite not leading to the same zinc recovery levels achieved with diesel oil.

  4. 王叔岷《史记斠证》商榷%The Studies on Shiji jiaozheng (《史记斠证》) by Wang Shu-min

    Institute of Scientific and Technical Information of China (English)

    杨小平

    2015-01-01

    文章逐一研讨了王叔岷《史记斠证》一书中“痢儿畔”“内”“太任”“岐”“罚”“迺”等词语,进而提出了商榷观点或者思考。%This paper discusses a series of Chinese characters or expression such as Lierban (痢儿畔)、 Nei (内)、 Tairen (太任)、 Qi (岐)、 Fan (罚)、 Nai (迺) etc in Shiji jiaozheng (《史记斠证》) by Wang Shu-min, puts forward some opinions about them.

  5. Toothpaste containing NovaMin is applied to treat dentine hypersensitivity%含生物活性玻璃离子牙膏治疗牙本质过敏症

    Institute of Scientific and Technical Information of China (English)

    李婵秀; 黄江勇; 梁焕友

    2013-01-01

    背景:NovaMin是一种生物活性玻璃离子,其有效成分与唾液发生反应后形成羟基磷灰石晶体沉积在牙齿表面,封闭暴露的牙本质小管,可用于治疗牙本质过敏症。  目的:观察龈下刮治和根面平整后含NovaMin生物活性玻璃子牙膏对患牙敏感症的影响。  方法:从543例患者中按照纳入和排除标准筛选出96例慢性牙周炎患者参加试验,遵照随机、双盲、对照的原则随机分成2组,进行龈下刮治和根面平整后,试验组用含NovaMin生物活性材料的专效修复抗敏牙膏刷牙,对照组用不含NovaMin生物活性材料的牙膏刷牙。分别在抗敏试验前和抗敏试验后4周采用目测类比疼痛评分评价患牙空气刺激的敏感程度。  结果与结论:共88例患者完成试验,两组各44例。使用牙膏4周后,试验组目测类比疼痛评分由抗敏试验前时的4.25±1.87降低至2.53±1.22,试验前后比较差异有显著性意义(P OBJECTIVE:To study the effect of toothpaste containing NovaMin on tooth hypersensitivity patients after subgingival scaling and root planing surgery. METHODS:According to inclusion and exclusion criteria, 96 patients were picked out from 543 patients to participate in the experiment. In compliance with the principle of randomized, double-blind, comparison, 98 subjects were randomly divided into two groups:experiment group in which the toothpaste containing NovaMin was used, and control group in which the toothpaste without NovaMin was used. Visual analog scale scoring was used to evaluate the degree of sensitivity to air stimulus respectively before and 4 weeks after al ergy experiment. RESULTS AND CONCLUSION:Total y 88 patients completed the experiment. After treatment with toothpaste for 4 weeks, visual analog scale scores in the experiment group decreased from 4.25±1.87 at baseline to 2.53±1.22 by air stimulus, and visual analog scale scores in the control group

  6. 姜树民教授从痈论治幽门螺杆菌阳性消化性溃疡经验%Experience of Professor JIANG Shu-min Treating Peptic Ulcer with Positive Hp Infection as Carbuncle

    Institute of Scientific and Technical Information of China (English)

    张野

    2012-01-01

    Professor JIANG Shu-min brings up the idea that treat peptic ulcer with positive Helicobacter pylori infection as carbuncle, he thinks peptic ulcer with positive Helicobacter pylori infection as internal-carbuncle, then makes treatments based on syndrome differentiation by using herbs which can regulate qi and activate blood circulation, and clear heat and detoxicate.%姜树民教授提出从痈论治幽门螺杆菌阳性的消化性溃疡,认为幽门螺杆菌阳性消化性溃疡乃内痈,运用理气活血、清热解毒药辨证施治.

  7. Ultra-large scale synthesis of high electrochemical performance SnO{sub 2} quantum dots within 5 min at room temperature following a growth self-termination mechanism

    Energy Technology Data Exchange (ETDEWEB)

    Cui, Hongtao, E-mail: htcui@ytu.edu.cn; Xue, Junying; Ren, Wanzhong; Wang, Minmin

    2015-10-05

    Highlights: • SnO{sub 2} quantum dots were prepared at an ultra-large scale at room temperature within 5 min. • The grinding of SnCl{sub 2}⋅2H{sub 2}O and ammonium persulphate with morpholine produces quantum dots. • The reactions were self-terminated through the rapid consumption of water. • The obtained SnO{sub 2} quantum dots own high electrochemical performance. - Abstract: SnO{sub 2} quantum dots are prepared at an ultra-large scale by a productive synthetic procedure without using any organic ligand. The grinding of solid mixture of SnCl{sub 2}⋅2H{sub 2}O and ammonium persulphate with morpholine in a mortar at room temperature produces 1.2 nm SnO{sub 2} quantum dots within 5 min. The formation of SnO{sub 2} is initiated by the reaction between tin ions and hydroxyl groups generated from hydrolysis of morpholine in the released hydrate water from SnCl{sub 2}⋅2H{sub 2}O. It is considered that as water is rapidly consumed by the hydrolysis reaction of morpholine, the growth process of particles is self-terminated immediately after their transitory period of nucleation and growth. As a result of simple procedure and high toleration to scaling up of preparation, at least 50 g of SnO{sub 2} quantum dots can be produced in one batch in our laboratory. The as prepared quantum dots present high electrochemical performance due to the effective faradaic reaction and the alternative trapping of electrons and holes.

  8. Spironolactone use and higher hospital readmission for Medicare beneficiaries with heart failure, left ventricular ejection fraction <45%, and estimated glomerular filtration rate <45 ml/min/1.73 m(2.).

    Science.gov (United States)

    Inampudi, Chakradhari; Parvataneni, Sridivya; Morgan, Charity J; Deedwania, Prakash; Fonarow, Gregg C; Sanders, Paul W; Prabhu, Sumanth D; Butler, Javed; Forman, Daniel E; Aronow, Wilbert S; Allman, Richard M; Ahmed, Ali

    2014-07-01

    Although randomized controlled trials have demonstrated benefits of aldosterone antagonists for patients with heart failure and reduced ejection fraction (HFrEF), they excluded patients with serum creatinine >2.5 mg/dl, and their use is contraindicated in those with advanced chronic kidney disease (CKD). In the present analysis, we examined the association of spironolactone use with readmission in hospitalized Medicare beneficiaries with HFrEF and advanced CKD. Of the 1,140 patients with HFrEF (EF mEq/L. Spironolactone use had significant PS-adjusted association with higher risk of 30-day (HR 1.41, 95% CI 1.04 to 1.90) and 1-year (HR 1.36, 95% CI 1.13 to 1.63) all-cause readmissions. The risk of 1-year all-cause readmission was higher among 106 patients with eGFR <15 ml/min/1.73 m(2) (HR 4.75, 95% CI 1.84 to 12.28) than among those with eGFR 15 to 45 ml/min/1.73 m(2) (HR 1.34, 95% CI 1.11 to 1.61, p for interaction 0.003). Spironolactone use had no association with HF readmission and all-cause mortality. In conclusion, among hospitalized patients with HFrEF and advanced CKD, spironolactone use was associated with higher all-cause readmission but had no association with all-cause mortality or HF readmission. PMID:24846806

  9. 基于最大流最小割算法的事件检测方案%Event Detection Scheme Based on Max-Flow/Min-Cut Algorithm

    Institute of Scientific and Technical Information of China (English)

    张瑞华; 程合友; 梁宇

    2016-01-01

    文中把最大流最小割算法应用于无线传感网络的事件检测中,针对边沿陡峭的事件,设计事件区域检测算法( G-Cut)。该算法首先将相邻节点的传感数据转化为权值,形成流网络;利用最大流最小割算法切割流网络,获得事件边界;再根据上传信息隐含的方向,确定事件区域。以野外火灾为例进行仿真实验,结果表明:文中算法事件检测准确度高,节点计算量低;针对多事件区域,在不增加节点计算量和通信量的情况下,仍可保证其检测准确度。%In this paper, the max-flow/min-cut algorithm is applied to the event detection in wireless sensor net-works, and an event detection algorithm ( G-Cut) is proposed for boundary-abrupt events.In the algorithm, firstly, the sensing data of adjacent nodes are transformed into weight values, and thus a flow network is formed.Then, the event boundary is obtained by using the max-flow/min-cut algorithm to cut the flow network.Finally, the event area is determined according to the direction implied in upload information.Simulation results on wildfire events show that the proposed algorithm achieves a high accuracy of event detection with a small computation amount of nodes, and for multi-event regions, it can guarantee the detection accuracy without increasing the computation amount and traffic of nodes.

  10. Veteran Herbalist Doctor HU Yuan-min's Crumbs of Experience for Insomnia Patients with Cardiovascular Disease%胡源民老中医治心血管病患者失眠之点滴

    Institute of Scientific and Technical Information of China (English)

    姚耿圳; 陈笑银

    2011-01-01

    胡源民老中医治疗心血管病患者失眠疗效显著,总以安神为首要治法,或滋养肝肾,或健脾开胃,或活血化瘀,或清热解毒,然治法每多相兼.此外还常采用针药并用,尤其重视宣教.兹将其常用药物特点介绍如下.%Veteran herbalist doctor HU Yuan-min's treatment on insomnia patients with cardiovascular disease has remarkable effect. His primary therapeutic method is to calm the mind; other methods include nourishing liver and kidney, or invigorating spleen and stimulating the appetite, or activating blood circulation for removing blood stasis, or clearing heat and removing toxicity, while those methods were frequently used together. In addition, he often uses acupuncture combined with herbs, and emphasizes on health education especially. The paper tries to introduce the common herbs characteristics of doctor Hu as below.

  11. Association entre les hormones sexuelles, les marqueurs de remodelage osseux et la densité minérale osseuse chez des femmes ménopausées d'origine marocaine (étude transversale)

    Science.gov (United States)

    El Maataoui, Aissam; Biaz, Asmae; El Boukhrissi, Fatima; El Machtani, Si; Dami, Abdellah; Bouhsain, Sanae; Bamou, Youssef; El Maghraoui, Abdellah; Ouzzif, Zhor

    2015-01-01

    Introduction Le présent travail se propose d’étudier la relation entre les hormones sexuelles, notamment l’œstradiol et l'indice de l’œstradiol libre, le sulfate de déhydroépiandrosterone et la sex hormone binding globulin, les marqueurs de remodelage osseux et la densité minérale osseuse chez une population de femmes marocaine ménopausées. Méthodes Il s'agit d'une étude transversale, menée sur une période de 6 mois d'octobre 2012 à fin avril 2013 et ayant fait participer deux cent deux (202). Résultats L’œstradiol et l'indice d’œstradiol libre (IEL) ont montré une corrélation négative respectivement à l'ostéocalcine (OC), à la crosslaps (β-CTX) et l'OC (ptravail montre que l'augmentation de l’âge et la diminution de l’œstradiol libre expliquent la diminution de la DMO au niveau du col du fémur, alors que l'augmentation du taux sérique de la SHBG et la diminution du poids expliquent la diminution de la DMO au rachis lombaire. PMID:26848353

  12. 琴音沧海:一种缘分二重叙事--为二胡演奏艺术家闵惠芬而写%On Erhu Artist Min Huifen

    Institute of Scientific and Technical Information of China (English)

    郭树荟

    2015-01-01

    In Chinese erhu music, Min Huifen established a contemporary aesthetic idea of ethnic music with the ideas of impart and inherit, and specialized vocabulary interpretation of the folk art. She pursuit of the erhu art with unique perseverance and pure, her wishful Chinese folk music that through her lively art history showed the unique spiritual feeling of an excellent.%闵惠芬在中国二胡音乐中,以专业化语汇诠释了民间艺术的音韵,以传承、创新的理念树立了当代民族音乐的审美观念。她特有的执着与纯粹,对二胡艺术的追求、对中国民族音乐的希翼,透过她生动的艺术历程,释放出一位优秀艺术家独特的精神情怀。

  13. Development of {sup 115}Cd/{sup 115m}ln generator for industrial and environmental applications; Desenvolvimento de um gerador de {sup 115}Cd/{sup 115m}In para aplicacoes industriais e ambientais

    Energy Technology Data Exchange (ETDEWEB)

    Camargo, Fernanda Cristina Fonseca

    2012-07-01

    Indium isotopes, {sup 111}In, '1{sup 13}ln and {sup 115}In are widely used as radiotracers in industrial and environmental applications. {sup 113m}ln generators can be found in the international market. However they are manufactured by only a few companies worldwide, are rated at rather high prices and not always are available for sale (they are frequently manufactured only upon request). Hence it is of interest to produce the equipment in the country in which it will be used, especially if the parent nuclide can be also produced there. In Brazil, the ideal situation would be to produce a {sup 115}Cd/{sup 115m}In generator, whose target precursor is the '1{sup 14}Cd. Preliminary tests using non-enriched and inactive CdO were developed. The parent and daughter nuclides were separated flowing the eluate containing the chemical species Cd (II) and In (III) through ion exchange resins, Ag11A8, Chelex100 and Oowex 1 x8. 0.1 M, 1 M and 2M HCI and 2M HCI + 0.1 M NH{sub 4}CI solutions were tested as the eluant. The amount of Cd (l I) and In (III) eluted were determined by ICP-AES. The irradiation conditions of the target {sup 114}CdO were defined according to the neutron flux provided TRIGA MARK-I-R IPR reactor and the nuclear properties the of target. After to preliminary tests with the {sup 115}Cd/{sup 115m}In pair, column experiments were developed. Analyses were accomplished by gamma spectrometry to determine the presence of the {sup 115}Cd and {sup 115m}ln nuclides in the fractions eluted. Tests using the resin AG IIA8 and HCI I M eluent solution resulted in 100% adsorption of the Cd (11) and nearly 50% elution of In (III), corresponding to the best conditions for elution. Exposure to radiation can damage the resins, as the decrease in ion exchange capacity and change in volume of the polymer grains. Thus, columns packed with the chosen resin were exposed to radiation doses from 15 to 200 Gy, and eluted with the most effective eluent. The results showed that

  14. Prevalence tendency of soil transmitted nematode infections in Min County by sentinel surveillance from 2006 to 2010%2006-2010年岷县土源性线虫病监测点流行趋势分析

    Institute of Scientific and Technical Information of China (English)

    杨俊克; 冯宇; 李凡; 陈生邦; 杨成明; 梁虹

    2012-01-01

    Objective To observe the prevalence tendency of soil transmitted nematodes infections in Min County,Gansu Province during 2006-2010 through constant surveillance on the population and soil samples detection,thus to provide evidence for making strategy of disease prevention and Control.Methods 1000 persons were investigated to find soil transmitted nematodes by sentinel surveillance.Eggs of A.Lumbricoides and T.trichiura were examined by Kato-Katz technique(3 thick smears per sample)while eggs of A.Lumbricoides examined for soil contamination in 10 families with saturate sodium nitrate floating method.The infection rates were compared among the five years.Eggs number of A.lumbricoides from soil and A.lumbricoides infection level of the families were obtained,then correlate analysis was applied.Results Soil transmitted nematodes infection rate in the population decreased from 20.31% to 11.08% in the five years,relative decreasing ratio was 44.26%.In the age group of 0-15,the infection rates were higher than those of older groups.The population with high infection rate was children live scattered,preschool children and students,respectively.Using correlate analysis by one side t test,number of soil A.lumbricoides eggs in the living environment and infection level of A.lumbricoides in those families had positive correlation,which indicated statistically significance exists (t =4.40,P < 0.10).Conclusion The infection rate of soil transmitted nematodes decreased significantly during 2006 to 2010 in Min County,but still prevailed with low incidence rate in the area.%目的 通过对甘肃省岷县国家级土源性线虫病监测点人群土源性线虫感染率和土壤蛔虫卵检出率的连续监测,观察其流行趋势,为制定防治策略提供依据.方法 2006-2010年期间,每年在岷县监测点整户调查1000人,改良加藤厚涂片法检测蛔虫、鞭虫虫卵,分析感染率;饱和硝酸钠漂浮法检测土壤蛔虫卵;对调查的10户土

  15. Associations between fruit, vegetable and legume intakes and prostate cancer risk: results from the prospective Supplémentation en Vitamines et Minéraux Antioxydants (SU.VI.MAX) cohort.

    Science.gov (United States)

    Diallo, Abou; Deschasaux, Mélanie; Galan, Pilar; Hercberg, Serge; Zelek, Laurent; Latino-Martel, Paule; Touvier, Mathilde

    2016-05-01

    Although experimental studies suggest that fruits, vegetables and legumes may exert protective effects against prostate carcinogenesis through various bioactive compounds such as dietary fibre and antioxidants, epidemiological evidence is lacking. Notably, very few prospective studies have investigated the relationship between legume intake and prostate cancer risk. Our objective was to prospectively investigate the association between fruit, vegetable, tomato products, potatoes and legume intakes and prostate cancer risk. This study included 3313 male participants to the SUpplémentation en VItamines et Minéraux AntioXydants cohort (follow-up: 1994-2007) who completed at least three 24-h dietary records during the first 2 years of follow-up. Associations between tertiles of intake and prostate cancer risk were assessed by multivariate Cox proportional hazards models. After a median follow-up of 12·6 years, 139 incident prostate cancers were diagnosed. An inverse association was observed between prostate cancer risk and tertiles of legume intake (hazard ratio (HR)T3v.T1=0·53; 95 % CI 0·34, 0·85; P trend=0·009). This association was maintained after excluding soya and soya products from the legume group (HRT3 v.T1=0·56; 95 % CI 0·35, 0·89; P trend=0·02). No association was observed between prostate cancer risk and tertiles of intakes of fruits (P trend=0·25), vegetables (P trend=0·91), potatoes (P trend=0·77) and tomato products (P trend=0·09). This prospective study confirms the null association between fruit and non-starchy vegetable intakes and prostate cancer risk observed in most previous cohorts. In contrast, although very few prospective studies have been published on the topic, our results suggest an inverse association between legume intake and prostate cancer risk, supported by mechanistic plausibility. These results should be confirmed by large-scale observational and intervention studies.

  16. Individualizing pharmacotherapy in patients with renal impairment: the validity of the Modification of Diet in Renal Disease formula in specific patient populations with a glomerular filtration rate below 60 ml/min. A systematic review.

    Directory of Open Access Journals (Sweden)

    Willemijn L Eppenga

    Full Text Available The Modification of Diet in Renal Disease (MDRD formula is widely used in clinical practice to assess the correct drug dose. This formula is based on serum creatinine levels which might be influenced by chronic diseases itself or the effects of the chronic diseases. We conducted a systematic review to determine the validity of the MDRD formula in specific patient populations with renal impairment: elderly, hospitalized and obese patients, patients with cardiovascular disease, cancer, chronic respiratory diseases, diabetes mellitus, liver cirrhosis and human immunodeficiency virus.We searched for articles in Pubmed published from January 1999 through January 2014. Selection criteria were (1 patients with a glomerular filtration rate (GFR < 60 ml/min (/1.73 m2, (2 MDRD formula compared with a gold standard and (3 statistical analysis focused on bias, precision and/or accuracy. Data extraction was done by the first author and checked by a second author. A bias of 20% or less, a precision of 30% or less and an accuracy expressed as P30% of 80% or higher were indicators of the validity of the MDRD formula. In total we included 27 studies. The number of patients included ranged from 8 to 1831. The gold standard and measurement method used varied across the studies. For none of the specific patient populations the studies provided sufficient evidence of validity of the MDRD formula regarding the three parameters. For patients with diabetes mellitus and liver cirrhosis, hospitalized patients and elderly with moderate to severe renal impairment we concluded that the MDRD formula is not valid. Limitations of the review are the lack of considering the method of measuring serum creatinine levels and the type of gold standard used.In several specific patient populations with renal impairment the use of the MDRD formula is not valid or has uncertain validity.

  17. Une masculinité en crise à la fin du XVIIe siècle ? La critique de l'efféminé chez La Bruyère

    Directory of Open Access Journals (Sweden)

    Cédric Corgnet

    2008-07-01

    Full Text Available L’efféminé est toujours un cas sexuel limite : homme aux airs féminins, il interroge l’innée de la nature sexuelle, critique les genres et leur définition explicitement physique. La fin du XVIIe siècle illustre cette tension chez les moralistes français et surtout chez La Bruyère dans ses Caractères où celui-ci interroge cette monstruosité générique à travers une analyse sémiologique. Mais cette tératologie n’est pas avant tout clinique mais sociale et morale : il nous avertit, par cet écart de genre, d’une corruption morale du monde tant par une sémiologie clinique que mythologique ovidienne ne cherchant pas le réalisme pathologique mais la filiation antique qui ante son ouvrage sur les Caractères Théophrastiens : philosophe plus que naturaliste.The effeminate is always a sexual limit case: man in the feminine sights, he questions the innate of the sexual nature, criticizes genders and their explicitly physical definition. The end of the XVIIth century illustrates this tension at the French moralists and especially in La Bruyère’s Characters where this one questions this generic monstrousness through a semiological analysis. But this teratology is not above all clinical but social and moral: he warns us, by this distance from gender, from a moral corruption of the world both by a clinical semiology and ovidian mythology not looking for the pathological realism but the antic filiation with Theophrast’s Characters : philosopher more than naturalist.

  18. Estudos por µXRF-Sincrotron de fluidos mineralizadores detectados em minérios uraníferos, ferríferos e depósitos epitermais

    Directory of Open Access Journals (Sweden)

    Francisco Javier Rios

    2006-12-01

    Full Text Available O método de análise não-destrutivo denominado Microfluorescência de Raios X. (µSXRF, radiação Sincrotron tem sido utilizado recentemente em laboratórios de luz Sincrotron de vários países para identificar e, em situações especiais, quantificar elementos menores, maiores e traços em inclusões fluidas. Com esse intuito, a estação de µSXRF do LNLS (Laboratório Nacional de Luz Sincrotron, Campinas foi utilizada para desenvolver estudos composicionais de inclusões fluidas em minerais transparentes (quartzo, adulária, esmeralda, piroxênio de diferentes jazidas minerais e minérios opacos de Ag e Fe.Synchrotron radiation micro X-ray fluorescence (SµXRF analysis is a non-destructive method that can be used to identify, and in special cases, to quantify major, minor, and trace elements present in fluid inclusions. In spite of the relevant results, this technique has been used only in a few studies, which, moreover, are mostly focused on either synthetic or natural fluid inclusions in transparent minerals. To investigate fluid inclusions in transparent and opaque minerals, the synchrotron radiation X-ray microprobe station from the µSXRF fluorescence beamline at the LNLS-Campinas was used. This analytical method has been proven to be efficient in the chemical characterization of the fluid inclusions constituents of some transparent (quartz, adularia, emerald, etc. and opaque minerals (pyrargyrite and hematite.

  19. Evidence that Ca2+ within the microdomain of the L-type voltage gated Ca2+ channel activates ERK in MIN6 cells in response to glucagon-like peptide-1.

    Directory of Open Access Journals (Sweden)

    Joanne Selway

    Full Text Available Glucagon like peptide-1 (GLP-1 is released from intestinal L-cells in response to nutrient ingestion and acts upon pancreatic β-cells potentiating glucose-stimulated insulin secretion and stimulating β-cell proliferation, differentiation, survival and gene transcription. These effects are mediated through the activation of multiple signal transduction pathways including the extracellular regulated kinase (ERK pathway. We have previously reported that GLP-1 activates ERK through a mechanism dependent upon the influx of extracellular Ca(2+ through L-type voltage gated Ca(2+ channels (VGCC. However, the mechanism by which L-type VGCCs couple to the ERK signalling pathway in pancreatic β-cells is poorly understood. In this report, we characterise the relationship between L-type VGCC mediated changes in intracellular Ca(2+ concentration ([Ca(2+](i and the activation of ERK, and demonstrate that the sustained activation of ERK (up to 30 min in response to GLP-1 requires the continual activation of the L-type VGCC yet does not require a sustained increase in global [Ca(2+](i or Ca(2+ efflux from the endoplasmic reticulum. Moreover, sustained elevation of [Ca(2+](i induced by ionomycin is insufficient to stimulate the prolonged activation of ERK. Using the cell permeant Ca(2+ chelators, EGTA-AM and BAPTA-AM, to determine the spatial dynamics of L-type VGCC-dependent Ca(2+ signalling to ERK, we provide evidence that a sustained increase in Ca(2+ within the microdomain of the L-type VGCC is sufficient for signalling to ERK and that this plays an important role in GLP-1- stimulated ERK activation.

  20. Modelo integrado de apoio ao planejamento da rede de serviços no transporte ferroviário de cargas: aplicação para transporte de minério de ferro

    Directory of Open Access Journals (Sweden)

    Luciano Bandeira Campos

    2011-04-01

    Full Text Available

    Resumo: Apresenta-se um modelo de otimização para auxiliar o planejamento tático ferroviário com visão integrada da rede (operações em linha e pátios, e que foi aplicado ao transporte de minério de ferro numa conhecida ferrovia brasileira, considerando o efeito congestionamento. O problema é de programação não linear inteira, e a solução foi obtida por um aplicativo computacional disponível no mercado. O objetivo é facilitar o planejamento da rede de serviços: quais trens (serviços devem ser operados, sua frequência, e a sequência recomendada das operações e serviços desde a origem das cargas até o destino. A pesquisa de literatura identificou um modelo que, mediante adaptações, foi aplicado ao fluxo de trens com diferentes opções preestabelecidas de configuração, desde 11 pontos de origem até um terminal exportador e passando por três pátios intermediários, onde os trens podem ser combinados entre si. Os resultados variam conforme a abordagem adotada para a função objetivo, com diferenças significativas na frequência dos diversos serviços disponíveis e no uso dos pátios intermediários.

    Abstract: This paper presents an optimization model developed to help tactical planning at railroads with an integrated view of the network (line and yard operations. The model was applied to iron ore transportation in a well-known Brazilian railroad, considering congestion effects. This is an integer nonlinear problem, which was solved by an optimization package. The objective is to help decision making related to service network design: which trains (services should run, how frequently and what should be the recommended sequence of activities to be performed at intermediate yards from origin to destination of cargo. Literature research identified a model that could be modified and adapted to the flow of different predefined train consist options, which are operated from 11 mines

  1. A influência da granulometria na flotação de rejeito de minério de zinco The influence of size distribution on the flotation of zinc ore tailings

    Directory of Open Access Journals (Sweden)

    Mário Luís Cabello Russo

    2008-06-01

    Full Text Available No mercado mundial, o valor dos metais tem aumentado consideravelmente. Todas as empresas mineradoras estão adotando medidas com o objetivo de otimizar seus processos de concentração, sempre visando retirar a máxima quantidade de metal de interesse do minério "ROM". Esse princípio é compatível com o alvo ambiental de minimização da geração de resíduos na atividade mineral. Beneficiando-se rejeitos, objetiva-se, tanto aumentar a produção, como, também, amenizar impactos ambientais. Esse trabalho apresenta uma análise dos fenômenos interfaciais que regem a flotação de silicatado de zinco, principalmente os finos, além de parâmetros para a concentração de rejeitos do circuito de flotação de willemita. As amostras de rejeito estudadas foram fornecidas pela Votorantim Metais, unidade de vazante. Depois de determinados quais reagentes respondem melhor ao processo e quais as suas condições ideais de dosagem, foram desenvolvidos testes de flotação em faixas granulométricas específicas, com o objetivo de se analisar o efeito do tamanho da partícula no processo de flotação.In the world market, the metal prices have been increasing considerably. All mining companies have adopted actions with the objective of minimizing their concentration processes, enhancing the recovery of the metal bearing mineral from the ROM. This line is compatible with the environmental target of minimizing the generation of wastes in the mining activities. It aims at increasing the zinc production, while reducing environmental impacts. The goal of the present investigation is to analyze the interface phenomena that control the flotation of zinc silicate, mainly the fines, and to determine which conditions concentrate the tailings of the willemite's flotation circuit. The samples of tailings were supplied by Votorantim Metais, Vazante. After determining the best reagents for the flotation and their dosages, flotation's tests was carried out with

  2. Grau de saponificação de óleos vegetais na flotação seletiva de apatita de minério carbonatítico

    Directory of Open Access Journals (Sweden)

    Jardel Alves de Oliveira

    2006-12-01

    Full Text Available Ensaios de flotação, em bancada, de amostras de minério fosfático granulado e friável de Tapira-MG foram efetuados, testando-se diferentes graus de saponificação de três coletores aniônicos: "Hidrocol parcialmente hidrogenado", "Hidrocol sem hidrogenação" (obtidos a partir de soja e ácido oléico. Os graus de saponificação usados foram de 40 %, 55 %, 70 %, 85 % e 100 %. Os ensaios foram feitos em pH 9,5. O óleo de babaçu, também cogitado como coletor, não permitiu grau de saponificação além de 40 %, mas serviu de controle da metodologia de quantificação do grau de saponificação. O Hidrocol parcialmente hidrogenado com grau de saponificação de 55 % foi o melhor, em termos de teor e recuperação de fósforo, relação CaO/P2O5 e teor de magnésia no concentrado, motivando testes de flotação em estágio de limpeza, sem e com a adição do coletor KE883B, um sulfosuccinato, também em pH 9,5, utilizando-se os óleos com grau de saponificação de 55 %. O Hidrocol parcialmente hidrogenado sem KE883B deu melhor resultado. Usou-se amido como depressor em todos os ensaios.Bench scale flotation experiments were performed testing three anionic collectors here called "partially hydrogenated Hidrocol", "non hydrogenated Hidrocol" (very similar oils from soybean and oleic acid, with saponification degrees of 40 %, 55 %, 70 %, 85 % and 100 %, in order to purify carbonatitic phosphate ores from Tapira. The value of flotation pH was 9.5. A refined babassu oil sample (extracted from the babassu palm seed kernel did not achieve a saponification degree above 40 %. Using the P2O5 content and recovery, the CaO/P2O5 ratio and MgO content of the concentrate as quality indicators, the best results were achieved with the saponification degree of 55%, for the oils tested. Cleaner lab flotation tests were carried out using the collectors with a saponification degree of 55%, at pH 9.5, in the absence and in the presence of KE883B (alkyl

  3. 煤矿开采对岩溶区水质及土壤的污染与评价%Effect of Coal Minning on Water Quality and Soil in Karst Area

    Institute of Scientific and Technical Information of China (English)

    苏春田; 谢代兴; 唐健生; 李兆林; 潘晓东; 梁小平

    2011-01-01

    对研究区煤矿开采背景下的土壤和地表河进行了重金属含量分析,并进行了质量评价.结果表明,地表河S1~S8样点Zn、Cd、Cu、As含量最高的为S1,Cr含量最高的为S3,Ni含量最高为S4:S1、S4、S5水样污染因子均为Cd、Zn.S2、S3、S6水样污染因子为Zn,质量级别均为中等.综合因子指数最大的为S1,质量级别为中等,最小的为S8,质量级别为好.土壤T1~T6样地As、Cu、Cr、Cd、Pb、Ni、Zn含量最高的为T1,As、Cu、Cr、Pb、Ni含量最低的为T5,Cd含量最低的为T6,Zn含量最低的为T4,样地污染因子均为Cd,质量级多为很坏,综合质量级别为中等-坏-很坏.%The effect of coal minning on water quality and soil in karst area were studied. In Sl~S8 river samples, the contents of Zn, Cd, Cu, and As were highest in SI, the content of Cr and Ni were highest in S3 and S4 respectively. The pollution factors of S1, S4, and S5 were all Cd and Zn, while S2, S3, S6 was Zn, its quality level were all medium. The comprehensive factor index of S1 was the largest, its quality level was medium, while S8 was the smallest, its quality level was good. In T1~T6 soil samples, the contents of As, Cu, Cr, Cd, Pb, Ni, and Zn were the highest in T1 ,while the contents of As, Cu, Cr, Pb, and Ni were the lowest in T5, the contents of Cd and Zn were the lowest in T6 and T4 respectively. The Pollution factors of soil in T1~T6 were all Cd, the quality level were almost very had , and the comprehensive quality level were medium-bad-very bad.

  4. 西秦岭岷县鹿儿坝金矿床地质特征及找矿远景%Geological characteristics and prospecting potentials of Lu'erba Gold Deposit in Min County,western Qinling

    Institute of Scientific and Technical Information of China (English)

    刘云华; 安静; 李宗会; 丁文军; 罗根根; 戚新世; 李真

    2014-01-01

    鹿儿坝金矿床是西秦岭地区的一处中型金矿床,赋矿围岩主要为中三叠统光盖山组长英砂岩、粉砂岩及粉砂质板岩等。在对矿床野外地质特征、矿石矿物组成、矿石结构构造、成矿元素组合详细研究的基础上,认为该区金矿体主要受近EW向脆性断裂构造控制,与闪长玢岩脉关系密切;矿石中金属矿物主要为黄铁矿、毒砂、辉锑矿、闪锌矿;石英、黄铁矿、毒砂为主要载金矿物,矿石类型主要有蚀变构造角砾岩型、蚀变闪长玢岩型、脉状及浸染状硫化物型、褐铁矿化碎裂岩型;流体测温、矿物组合及蚀变特征显示本区为中低温热液金矿床;硫、铅同位素研究结果表明,成矿物质具有深源特征。结合区域矿床研究结果,认为鹿儿坝金矿床形成于印支末期,为与闪长岩脉有关的斑岩型-蚀变岩型金矿床,矿床剥蚀深度较浅,目前所见到金矿体可能大部分为闪长玢岩脉(体)上部破碎带中的蚀变岩型金矿床,深部具有较大的成矿和找矿潜力。%Lu'erba Gold Deposit in Min County is a middle gold deposit in western Qinling region.The deposit mainly lies in sandstones,siltstones and silty slates of middle triassic felsic Guanggaishan group.This paper based on the detailed study of Lu'erba Gold Deposit's field geological characteristics,ore mineral constituents,ore textures and structures and ore element association,identifies that the gold deposit is mainly controlled by EW brittle faults and has close relations with diorite-porphyrite;The main ore minerals are pyrite,arsenopyrite,stibnite and sphalerite.Pyrite, arsenopyrite and quartz are the main gold-bearing minerals.The types of ore are altered tectonic breccia,altered diori te-porphyrite,veined and disseminated sulfide ores and cataclastic rock of ferritization;Fluid temperature,mineral as-semblages and alteration features indicate that the area is

  5. Caracterização da parcela magnética de minério fosfático de carbonatito Characterization of the magnetic phase from carbonatitic phosphate ore

    Directory of Open Access Journals (Sweden)

    Alysson A. Borges

    2008-03-01

    Full Text Available O rejeito magnético do Complexo Mineração de Tapira, Tapira - MG, onde se processa rocha fosfática, foi estudado. Suas principais características físicas, químicas e mineralógicas foram determinadas, assim como suas respostas a processos de concentração. A primeira etapa do trabalho envolveu análise granulométrica, análise química, difratometria de raios X, espectroscopia Mössbauer, microscopia ótica e microscopia eletrônica de varredura. Na segunda etapa, ensaios de separação magnética, flotação e lixiviação ácida foram realizados. O material sob estudo revelou-se composto essencialmente por magnetita, hematita (martita e ilmenita. A separação magnética resultou em recuperação metalúrgica de ferro acima de 96 %. Sabão sódico de ácido graxo vegetal (Hidrocol deu melhores resultados no processo de flotação, comparado ao desempenho de amina, quando empregados como coletores de silicatos e apatita, visando à depuração dos minerais portadores de ferro. A atrição preliminar ao condicionamento não influenciou sensivelmente a flotação. Os ensaios de lixiviação visaram a eliminação de fósforo, contaminante crítico nos minérios de ferro. O ácido acético extraiu 0,41 % do fósforo presente, enquanto o ácido clorídrico extraiu em torno de 73 % do fósforo. Estudos ulteriores de otimização de tais ensaios são recomendados, buscando o uso do material sob estudo em siderurgia.The characterization of the magnetic fraction of a tail from phosphate rock processing was done. Samples were from Tapira, in Minas Gerais, Brazil. The main physical, chemical and mineralogical properties, as well as this material response to separation processes were determined. The first part of this work encompasses the mineralogical characterization (determination of particle size distribution, X-ray diffraction, Mössbauer spectroscopy, optical microscopy and scanning electron microscopy. In the second part, concentration

  6. The effects of Berberine on growth of Immorto-Min colonic epithelial cell line%小檗碱对永生化结肠细胞系生长的影响及其机制

    Institute of Scientific and Technical Information of China (English)

    曹海龙; 王邦茂; 鄢芳; 陈鑫

    2011-01-01

    Objective To investigate the effects of Berberine on growth of Immorto-Min colonic epithelial cell line (IMCE) and explore its possible mechanisms. Methods IMCE cells were treated with Berberine in the absence or presence of epidermal growth factor (EGF) and TNFα. Ki-67 staining and terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling (TUNEL) assay were used to identify the cell proliferation and apoptosis respectively. Furthermore, Western blot analysis was performed to detect the epidermal growth factor receptor ( EGFR), protein kinase B (Akt) and their phosphorylation.Results ( 1 ) Proliferating activity of IMCE cells was increased after adding EGF and the proportion of cell proliferation was ( 10. 64 ± 1.41 ) %. The proportion was significantly lowed in EGF plus Berberine group [(1.81 ±0. 85)%] compared to the EGF group(P <0. 01 ), while the lowest was the Berberine group [(0.49 ± 0.42) %]. (2) The proportions of cell apoptosis were ( 8.47 ± 2. 52 ) % and (9. 39 ± 2. 13 ) %in the Berberine group and TNFt group respectively which were significantly higher compared to the normal control [(0. 27 ± 0. 30)%], both P < 0. 01. (3) The phosphorylation of EGFR was significantly increased after adding EGF and p-EGFR was decreased in EGF plus Berberine group at a concentration-dependent manner. (4) Moreover, the phosphorylation of Akt was enhanced after addition of TNFα , while the phosphorylation in the TNFα and Berberine group was inhibited compared to the TNFα group. Conclusions Berberine may suppress the proliferation and promote the apoptosis of IMCE cells. The mechanisms may relate to the inhibition of the phosphorylation of EGFR and Akt.%目的 观察小檗碱对永生化结肠细胞系(IMCE)生长的影响,探讨其可能机制.方法 IMCE细胞在存在及不存在表皮生长因子(EGF)或TNFα的情况下加入小檗碱,以Ki-67免疫细胞化学染色对有增殖活性的细胞进行标记,采用原位末端转移酶标

  7. A combination of high dose rate (10X FFF/2400 MU/min/10 MV X-rays) and total low dose (0.5 Gy) induces a higher rate of apoptosis in melanoma cells in vitro and superior preservation of normal melanocytes.

    Science.gov (United States)

    Sarojini, Sreeja; Pecora, Andrew; Milinovikj, Natasha; Barbiere, Joseph; Gupta, Saakshi; Hussain, Zeenathual M; Tuna, Mehmet; Jiang, Jennifer; Adrianzen, Laura; Jun, Jaewook; Catello, Laurice; Sanchez, Diana; Agarwal, Neha; Jeong, Stephanie; Jin, Youngjin; Remache, Yvonne; Goy, Andre; Ndlovu, Alois; Ingenito, Anthony; Suh, K Stephen

    2015-10-01

    The aim of this study was to determine the apoptotic effects, toxicity, and radiosensitization of total low dose irradiation delivered at a high dose rate in vitro to melanoma cells, normal human epidermal melanocytes (HEM), or normal human dermal fibroblasts (HDF) and to study the effect of mitochondrial inhibition in combination with radiation to enhance apoptosis in melanoma cells. Cells irradiated using 10X flattening filter-free (FFF) 10 MV X-rays at a dose rate of 400 or 2400 MU/min and a total dose of 0.25-8 Gy were analyzed by cell/colony counting, MitoTracker, MTT, and DNA-damage assays, as well as by quantitative real-time reverse transcriptase PCR in the presence or absence of mitochondrial respiration inhibitors. A dose rate of 2400 MU/min killed on average five-fold more melanoma cells than a dose rate 400 MU/min at a total dose of 0.5 Gy and preserved 80% survival of HEM and 90% survival of HDF. Increased apoptosis at the 2400 MU/min dose rate is mediated by greater DNA damage, reduced cell proliferation, upregulation of apoptotic genes, and downregulation of cell cycle genes. HEM and HDF were relatively unharmed at 2400 MU/min. Radiation induced upregulation of mitochondrial respiration in both normal and cancer cells, and blocking the respiration with inhibitors enhanced apoptosis only in melanoma cells. A high dose rate with a low total dose (2400 MU/min, 0.5 Gy/10X FFF 10 MV X-rays) enhances radiosensitivity of melanoma cells while reducing radiotoxicity toward HEM and HDF. Selective cytotoxicity of melanoma cells is increased by blocking mitochondrial respiration.

  8. Neonates recovering from neonates 1 minute Apgar scores 0-1 : perinatal factors and neurological outcome%影响1min Apgar评分0~1分新生儿的围产期因素及复苏后结局分析

    Institute of Scientific and Technical Information of China (English)

    余彦亮; 张谦慎; 杨传忠; 朱小瑜

    2015-01-01

    目的 探讨影响1 min Apgar评分0~1分新生儿复苏结局的围产期因素、复苏过程及5 min Apgar评分对神经系统预后的影响.方法 回顾性分析2010-2013年4年间在本院分娩的1 min Apgar评分0~1分的重度窒息患儿围产期因素和复苏后的临床资料.结果 研究期间共有38例1 min Apgar评分0~1分患儿,1例放弃抢救,6例死亡,31例复苏成功患儿(81.6%)转入NICU进一步治疗,其中2例住院48 h内放弃治疗.1 min Apgar评分0~1分的围产期因素主要有胎盘早剥(9例)、早产(7例),先天畸形(4例)、羊水Ⅲ度污染(4例)、脐带异常(4例)和分娩困难(4例)等.31例成功复苏的0~1分重度窒息患儿中,5 min Apgar评分≤5分者(15例)脐动脉血气pH <7.0、早期有神经系统症状、头颅磁共振改变的比例均高于5 min评分>5分者(16例),差异有统计学意义(P<0.05),两组脑瘫发生率差异无统计学意义(P =0.072).结论 积极有效的复苏可使绝大多数1 min Apgar评分0~1分新生儿抢救成功,5 min Apgar评分≤5分患儿是重点关注人群.

  9. Evaluation of Some (n,n'), (n,γ), (n,p), (n,2n) and (n,3n) Reaction Excitation Functions for Fission and Fusion Reactor Dosimetry Applications; Evaluation of the Excitation Functions for the 54Fe(n,p)54Mn, 58Ni(n,2n)57Ni, 67Zn(n,p)67Cu, 92Mo(n,p)92mNb, 93Nb(n,γ)94Nb, 113In(n,n')113mIn, 115In(n,γ) 116mIn, and 169Tm(n,3n)167Tm Reactions. Progress Report on Research Contract No 16242

    International Nuclear Information System (INIS)

    Cross section data for the 54Fe(n,p)54Mn, 58Ni(n,2n)57Ni, 67Zn(n,p)67Cu, 92Mo(n,p)92mNb, 93Nb(n,γ)94Nb, 113In(n,n')113mIn, 115In(n,γ)116mIn, 169Tm(n,3n)167Tm reactions are needed to solve a wide spectrum of scientific and technical tasks. Activation detectors based on these reactions may be used in the field of reactor dosimetry. Furthermore, the 54Fe(n,p)54Mn reaction is often used in experimental nuclear physics as a monitor reaction for measurements of unknown cross sections by means of the activation method over the neutron energy range from 5 to 15 MeV. The 93Nb(n,γ)94Nb reaction is also very promising for using in retrospective neutron dosimetry for determination of total neutron fluence during a campaign of a reactor. In the existing version of the International Reactor Dosimetry File and the new extended version named as IRDFF data for excitation functions of 67Zn(n,p)67Cu, 92Mo(n,p)92mNb, 113In(n,n')113mIn, and 169Tm(n,3n)167Tm reactions are absent. Data for these reactions are also absent in the JENDL/D-99 dosimetry file. Excitation functions of 67Zn(n,p)67Cu and 169Tm(n,3n)167Tm are presented in the TENDL-2012, EAF-2010, JENDL-4.0, JEFF-3.1/A, MENDL-2 libraries. Cross section data for the 67Zn(n,p)67Cu reaction up to 20 MeV are given also in the JENDL/HE-2007 library. Excitation functions of the 92Mo(n,p)92mNb and 113In(n,n')113mIn reactions are evaluated in the EAF-2010 and JEFF-3.1/A libraries. Cross section data for the 113In(n,n')113mIn reaction are given also in the TENDL-2010 library. It is necessary to note that neutron data in the JEFF-3.1/A and JENDL-4.0 libraries were evaluated up to 20 MeV. Neutron data in the TENDL-2012, EAF-2010, MENDL-2 and TENDL-2010 libraries had been evaluated up to 30 MeV, 60 MeV, 100 MeV and 200 MeV, respectively. Neutron cross sections in the MENDL-2, TENDL-2010 and TENDL-2012 libraries had been obtained on the basis of pure theoretical model calculations and are not appropriate for reactor and fusion dosimetry

  10. CHOP-like chemotherapy with or without rituximab in young patients with good-prognosis diffuse large-B-cell lymphoma: 6-year results of an open-label randomised study of the MabThera International Trial (MInT) Group

    DEFF Research Database (Denmark)

    Pfreundschuh, Michael; Kuhnt, Evelyn; Trümper, Lorenz;

    2011-01-01

    The MInT study was the first to show improved 3-year outcomes with the addition of rituximab to a CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone)-like regimen in young patients with good-prognosis diffuse large-B-cell lymphoma. Extended follow-up was needed to establish long...

  11. ak_sc_2min.new.grd

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NGDC builds and distributes high-resolution, coastal digital elevation models (DEMs) that integrate ocean bathymetry and land topography to support NOAA's mission...

  12. OnlineMin: A Fast Strongly Competitive Randomized Paging Algorithm

    DEFF Research Database (Denmark)

    Brodal, Gerth Stølting; Moruz, Gabriel; Negoescu, Andrei

    2012-01-01

    n the field of online algorithms paging is one of the most studied problems. For randomized paging algorithms a tight bound of H k on the competitive ratio has been known for decades, yet existing algorithms matching this bound have high running times. We present the first randomized paging...

  13. Mexico Gravity Data per 2 min Cell (97)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This 2' gravity density grid for Mexico, North-Central America, and the Western Caribbean Sea shows the distribution of about one million terrestrial and marine...

  14. 2.5-min gravity grid of N. America

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The dgrav gridded data set was produced by NGDC by regridding the Decade of North American (DNAG) 6-km gravity grid of N. America. A grid cell dimension of 2.5...

  15. Thresholded Covering Algorithms for Robust and Max-Min Optimization

    CERN Document Server

    Gupta, Anupam; Ravi, R

    2009-01-01

    The general problem of robust optimization is this: one of several possible scenarios will appear tomorrow, but things are more expensive tomorrow than they are today. What should you anticipatorily buy today, so that the worst-case cost (summed over both days) is minimized? Feige et al. and Khandekar et al. considered the k-robust model where the possible outcomes tomorrow are given by all demand-subsets of size k, and gave algorithms for the set cover problem, and the Steiner tree and facility location problems in this model, respectively. In this paper, we give the following simple and intuitive template for k-robust problems: "having built some anticipatory solution, if there exists a single demand whose augmentation cost is larger than some threshold, augment the anticipatory solution to cover this demand as well, and repeat". In this paper we show that this template gives us improved approximation algorithms for k-robust Steiner tree and set cover, and the first approximation algorithms for k-robust Ste...

  16. Keep Kids' Mouths Healthy: Brush 2min2X

    Science.gov (United States)

    ... More about BRUSHING Visit a Dentist Visit a Dentist Take your kids to see a dentist no ... and freshen breath. Visit a dentist Visit a Dentist Kids and parents – it’s important to visit ...

  17. Alaska Gravity Data per 2 x 4 min Cell (96)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This 2' x 4' gravity density grid for Alaska displays the distribution of about 1.1 million terrestrial and marine gravity data held in the National Geodetic Survey...

  18. Rør blot ikke ved min Thailands-tur

    DEFF Research Database (Denmark)

    Petersen, Lars Kjerulf

    2010-01-01

    Klimabevidsthed er ved at blive en fast understrøm i danskernes kollektive bevidsthed. Men klimahensyn er dog langt fra lige så selvfølgeligt som hensynet til velfærd eller øget økonomisk vækst. Og hensyn til miljøet er ligefrem et ugyldigt argument i mange sammenhænge. F.eks. udløser det kold...

  19. Hawaiian Islands Gravity Data per 2 min Cell (96)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This 2' gravity density grid for the Principal Hawaiian Islands displays the distribution of about 61,000 terrestrial and marine gravity data held in the National...

  20. Hip hurra, det er min fødselsdag. Eller?

    DEFF Research Database (Denmark)

    Hansen, Nils Gunder

    2013-01-01

    Den verdensberømte japanske forfatter Haruki Murakami har udvalgt 11 noveller og selv skrevet en 12., der alle kredser om fødselsdage. Det er melankolsk, mørk og frem for alt mesterlig læsning......Den verdensberømte japanske forfatter Haruki Murakami har udvalgt 11 noveller og selv skrevet en 12., der alle kredser om fødselsdage. Det er melankolsk, mørk og frem for alt mesterlig læsning...

  1. U.S. Gravity Data per 2 min Cell (96)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This 2' gravity density grid for the conterminous United States displays the distribution of the about 1.8 million terrestrial and marine gravity data held in the...

  2. Detection of 160 min solar intensity variations: Sampling effect

    International Nuclear Information System (INIS)

    The hypothesis that the 2h40m period in the Crimean and Stanford global solar velocity oscillation measurements, which is close to a 1/9 of a day, might be produced partly by a 1-day sampling regularity in observations, is checked using the IR center-limb intensity variations measurements. We find: a) The power spectrum of the series of these data does show a peak near the 2 h 40 m period. b) Power spectra of the series with observing windows 'filled' with a constant do not exhibit a significant peak at the 9th harmonic of a day, nor do the power spectra of the set with observing windows 'filled' with randomly generated numbers. Accordingly, we conclude that the analysis performed on the really observed data is not biased by the effect of data windows and a 1-day sampling regularity of observations. (orig.)

  3. PR/VI Gravity Data per 2 min Cell (96)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This 2' gravity density grid for Puerto Rico and the Virgin Islands displays the distribution of about 26,000 terrestrial and marine gravity data held in the...

  4. The Comparison between Adaptive Approach and Max-min Ant Colony Algorithm for Logistics Vehicle Routing Optimization%自适应和最大最小蚁群算法的物流车辆路径优化比较

    Institute of Scientific and Technical Information of China (English)

    陈昌敏; 谢维成; 范颂颂

    2011-01-01

    Aiming at the drawbacks of slow convergence speed and being easy to fall into local optimal point for basic ant colony algorithm in logistics vehicle routing optimization issue, this paper adopted an adaptive ant colony algorithm and the max-min ant colony algorithm to overcome the basic ant colony' s shortcomings.The analysis and comparison for the two algorithms were conducted,and the simulation of vehicle routing optimization in Matlab environment using adaptive and max-min ant colony algorithm was performed as well.Experimental results show that the max-min ant colony algorithm is better than adaptive ant colony algorithm in convergence speed and shortest path search, so max-min ant colony algorithm is superior to adaptive ant colony algorithm for logistics vehicle routing optimization.%针对物流车辆路径优化问题,考虑到基本蚁群算法有收敛速度慢、易陷入局部最优的缺点,采用了自适应蚁群算法和最大最小蚁群算法进行车辆路径优化,分析、比较了这两种算法的不同并在Matlab上做了仿真.仿真实验结果显示自适应蚁群算法在收敛速度和寻找最短路径上都略逊于最大最小蚁群算法,最大最小蚁群算法在物流车辆路径优化上优于适应蚁群算法.

  5. Fatores perinatais associados a recém-nascidos de termo com pH<7,1 na artéria umbilical e índice de Apgar <7,0 no 5º minuto Perinatal factors associated with pH<7.1 in umbilical artery and Apgar 5 min <7.0 in term newborn

    Directory of Open Access Journals (Sweden)

    Patrícia de Moraes De Zorzi

    2012-08-01

    Full Text Available OBJETIVO: Avaliar os fatores perinatais associados a recém-nascidos de termo com pHPURPOSE: To assess perinatal factors associated with term newborns with pH<7.1 in the umbilical artery and 5th min Apgar score<7,0. METHODS: Retrospective case-control study carried out after reviewing the medical records of all births from September/1998 to March/2008, that occurred at the General Hospital of Caxias do Sul. The inclusion criterion was term newborns who presented a 5th min Apgar score <7.0 and umbilical artery pH<7.10. In the univariate analysis, we used the Student's t-test and the Mann-Whitney test for continuous variables, the c² test for dichotomous variables and risk estimation by the odds ratio (OR. The level of significance was set at p<0.05. RESULTS: Of a total of 15,495 consecutive births, 25 term neonates (0.16% had pH<7.1 in the umbilical artery and a 5th min Apgar score <7.0. Breech presentation (OR=12.9, p<0.005, cesarean section (OR=3.5, p<0.01 and modified intrapartum cardiotocography (OR=7.8, p<0.02 presented a significant association with the acidosis event. Among the fetal characteristics, need for hospitalization in the neonatal intensive care unit (OR=79.7, p <0.0001, need for resuscitation (OR=12.2, p <0.0001 and base deficit were associated with the event (15.0 versus -4.5, p<0.0001. CONCLUSION: Low Apgar score at the 5th min of life associated with pH<7.1 in the umbilical artery can predict adverse neonatal outcomes.

  6. Influence du type d’addition minérale sur les propriétés de transfert des Bétons AutoPlaçants Influence of the type of mineral admixtures on the transport properties of self compacting concrete

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    Khelafi H.

    2012-09-01

    Full Text Available La formulation des bétons autoplaçants (BAP présente certaines spécificités dont un volume élevé de pâte et une quantité importante d’ajouts minéraux. Ces deux paramètres influencent sensiblement les propriétés de transfert de ces bétons. Dans ce travail, nous avons étudié l’influence de la nature et du pourcentage de plusieurs additions minérales sur certaines propriétés de transfert (la diffusion des ions chlore et la perméabilité au gaz des BAP. Trois différentes additions minérales ont été testées : des fillers calcaires, de la pouzzolane naturelle et des cendres volantes. Ensuite, nous avons cherché une probable relation analytique entre ces propriétés et la résistance à la compression de ces bétons. Au total, douze formulations ont été étudiées, elles couvrent trois différentes classes de résistances (30 MPa, 50 MPa et 70 MPa et quatre types de bétons: un béton ordinaire vibré, un BAP à base de pouzzolanes naturelles, un BAP à base de fillers calcaires et un BAP à base de cendres volantes. Les résultats montrent que la nature de l’addition minérale dans les BAP influe considérablement sur les propriétés de transferts de ces bétons. Après 28, 90 et 360 jours de cure, les BAP contenant de la pouzzolane naturelle représentent des performances très comparables à celles obtenues sur des BAP à base de cendres volantes et bien meilleures que celles obtenues sur des BAP formulés avec du filler calcaire. Indépendamment du type d’addition minérale, les résultats confirment l’existence d’une forte corrélation entre le développement de la résistance à la compression et les propriétés de transferts des BAP. Formulation of self compacting concrete (SCC has some specific characteristics including a high volume of paste and a large amount of mineral admixtures. These two parameters influence significantly the transport properties of SCC. In this work, we studied the influence of

  7. Aplicação da espectroscopia de reflectância difusa na quantificação dos constituintes de bauxita e de minério de ferro Application of diffuse reflectance spectroscopy in the quantification of the constituents of bauxite and iron ore

    Directory of Open Access Journals (Sweden)

    Ana Cláudia Carioca

    2011-06-01

    Full Text Available Esse trabalho teve como objetivo a aplicação da espectrofotometria de reflectância difusa no desenvolvimento de uma metodologia para a identificação e quantificação de minerais presentes na bauxita e nos minérios de ferro. Amostras selecionadas contendo uma variabilidade mineral foram coletadas na região do Quadrilátero Ferrífero e na região de Carajás e os teores dos diferentes minerais foram estimados a partir de uma combinação de métodos convencionais, tais como análise química, difração de raios X, espectroscopia Mössbauer, susceptibilidade magnética e microscopia ótica. Os dados espectrais obtidos na reflectância difusa nas regiões do visível e do infravermelho juntamente com a composição mineralógica foram analisados por algoritmos quimiométricos. A análise de correlação mineralógica apresentou resultados satisfatórios, tendo parâmetros estatísticos médios próximos de R² = 0,93, para bauxita, e de R² = 0,87, para minério de ferro. Por exemplo, para a goethita, presente no minério de ferro, o R² = 0,96; com erro-padrão médio de calibração (RMSEC = 3,6%, e, para a hematita, presente também no minério de ferro, o R² = 0,90 com o RMSEC = 7,3%. Os resultados sugerem que a espectroscopia de reflectância difusa é uma ferramenta promissora para a quantificação simultânea dos minerais presentes em bauxita e minério de ferro.This paper describes the application of diffuse reflectance spectroscopy in the development of a methodology for the identification and quantification of minerals in bauxite and iron ores. Selected samples containing a mineral variability were collected from the Iron Quadrangle (Minas Gerais mines and from the region of Carajás (Pará. The different mineral concentrations were estimated from a combination of conventional methods such as chemical analysis, Mössbauer spectroscopy, Xray diffractions, magnetic susceptibility and optical microscopy. Diffuse reflectance

  8. 浅析闽浙赣革命根据地的党组织和军队建设-以古田会议决议为中心%On the Party Organization Construction and the Construction of the Min-Zhe-Gan Army Revolutionary Base -Around the Resolution of Gutian Meeting

    Institute of Scientific and Technical Information of China (English)

    吴文燕

    2012-01-01

    闽浙赣革命根据地,又被称为“方志敏式根据地”,是在土地革命战争时期中国共产党领导赣东北人民,经过艰难困苦、坎坷曲折的斗争建立和发展起来的。闽浙赣的党组织对革命新道路进行了勇敢探索,并开辟出了一种与“农村包围城市,武装夺取政权”的中国革命正确道路精神内核高度一致的根据地发展模式,其党组织和军队建设也是成功贯彻古田会议决议精神和原则的典范,为今天新形势下党组织建设、国防和军队建设提供了宝贵的经验和借鉴。%Min-Zhe-Gan army revolutionary base, also known as Fang Zhimin army Revolutionary base, was established by the people of north-east Jiangxi who were leadered by the Communist Party of China after difficult and rough fights. The CCP of the Min-Zhe-Gan army revolutionary base paid hard exploration on the new road of revolution and opened up a new pattern of development which was the same as the correct Chinese revolution road "Rural areas surrounding the city, seize political power by armed forces". The party organization construction and the construction of the Min-Zhe-Gan army revolutionary base is the successful implementation of spirit and principle of resolutions of Gutian meeting which provides valuable experience and reference to Party organization construction, national defense and army construction under the new situation.

  9. Caractérisation géochimique et isotopique dans un système d'altération complexe, du protolithe magmatique à la minéralisation Fe-Pb-Zn: le cas de la mine de Tamra (N. Tunisie)

    OpenAIRE

    Decrée, Sophie

    2008-01-01

    L’objectif principal de cette thèse est de décrire et interpréter la mise en place des différents types de minéralisations présents dans le district minier de Nefza (NO de la Tunisie), qui constitue une région complexe et particulière du point de vue géologique dans ce pays.En effet, outre la présence de diapirs triasiques (commune à tout le Nord de la Tunisie), le district minier de Nefza est caractérisé par :(1) la mise en place d’épaisses nappes au Néogène qui forment le substratum sédimen...

  10. Baheji, a Unique Seasoning in the 6th Century of China -- Interpretation of Baheji, a Seasoning Captured in Qi Min Yao Shu%中国六世纪之特色复合调料:“八和銮”——《齐民要术》“八和銮”之文化解读

    Institute of Scientific and Technical Information of China (English)

    金洪霞; 郭华波; 赵建民

    2012-01-01

    《齐民要术》卷八中记载的“八和盎”,是由八种不同风味的原料调制而成的辛香味型复合调料,是专门用来佐食“脍”肴的佳品。我国古代美味“銮”有多种,各有风味特色。《齐民要术》关于“八和盎”的记载,弥补了历史文献无“金銮”描述的缺憾,也创立了记录菜肴制作工艺的典范,保留了失传的《食经》中的珍贵资料,具有重要的历史文化价值。%Baheji, which is captured in Qi Min Yao Shu or Important Arts for the People' s Welfare, an ancient Chinese book on agriculture, is a compound seasoning produced by mixing 8 different ingredients. It is exclusively used to enhance the flavor of food. There are a variety of Ji in the ancient China, each featuring a unique flavor. The description of Baheji by Qi Min Yao Shu fills the relevant gap in the historic literature of food. Besides, it also sets a model in recording the art of preparing food and preserves the valuable material from Shijing, a legendary masterpiece on food culture. Therefore, the chapter of Baheji is of remarkable his- torical value.

  11. A Sociolinguistic Survey of the Address Forms for Young Female Customers:A Case Study in Guangdong Dianbai Min Dialect%青年女性顾客称谓语的社会语言学调查--广东电白闽方言的个案研究

    Institute of Scientific and Technical Information of China (English)

    崔少娟

    2014-01-01

    广东电白闽方言区对青年女性顾客的通用称谓语是“靓妹”“靓姐”,极少使用“美女”称呼。根据电白闽方言区青年女性顾客的称谓语的使用频率来分析其原因,发现交际双方的爱美心理、称谓语本身的语音条件、商业交际场所的不同、发话者性别和年龄的差异、地方民俗文化色彩等因素对青年女性顾客的称谓语的选用有很大的影响和制约。%The common address forms for young female customers in Guangdong Dianbai Min Dialect area are “li-angmei” and “liangjie”, while “meinu” is rarely used.We analyze the reasons according to the Frequency of ad-dress forms for young female customers in Guangdong Dianbai Min Dialect area , and found that the factors influence and restrict the selection of address forms for young female customers are the love for beauty of the communicative parties, the voice conditions of the address forms , the difference of business communication places , the gender and age differences of the speakers and local folk culture.

  12. Características físicas dos minérios de caulim das minas floresta, Cavalheiro, Turvo e Kowalski, em Campo Alegre (SC, e de Trigolândia (PR Physical characteristics of kaolin ores from Floresta, Cavalheiro, Turvo and Kowalski Mines (SC and from Trigolândia Mine (PR

    Directory of Open Access Journals (Sweden)

    J. C. Biondiv

    2000-06-01

    Full Text Available A OXFORD fez, em seus minérios, 244 determinações de resistência a flexão, 1601 determinações da retração do minério a 110 ºC, 1508 determinações da retração após queima a 1220 ºC, 877 determinações de perda ao fogo, 1544 de absorção de água, 2288 determinações da dilatação linear a após secagem a 110 ºC e 1128 da dilatação linear após queima a 1220 ºC. Os valores médios, máximos, mínimos e as distribuições dos resultados dessas análises estão mostrados em tabelas e gráficos. Essas determinações e as observações de campo mostram que os depósitos estudados são de dois tipos, denominados Modelo Trigolândia, derivado de pegmatitos, e Modelo Floresta, derivado de rochas vulcânicas ácidas. Com exceção do minério da Mina do Turvo, as médias dos valores das propriedades físicas analisadas estão sempre dentro do intervalo de valores suportado pelo processo industrial da OXFORD. O minério verde, quase todo da Mina Turvo, e o minério marron são os que têm propriedades mais discordantes dos padrões desejados. Nas correlações entre os valores médios das propriedades físicas analisadas foi constatado que as correlações ruins são sempre devidas ao minério de Trigolândia. Considerando todos os valores analisados e não mais as suas médias, nota-se que, com exceção da correlação entre a % de retração após secagem a 110 ºC e a % de retração total, com r = 0,78, todos os outros coeficientes de correlação são muito baixos, menores que 0,60.OXFORD has made 244 determinations of modulus of rupture, 1601 determinations of dry contraction 110 ºC, 1508 determinations of fired contraction 1220 ºC, 877 determinations of ignition loss, 1544 determinations of apparent porosity, 2288 determinations of dry linear dilation (dried at 110 ºC and 1128 determinations of fired linear dilation (fired at 1220 ºC on their kaolin ores. The averages, maximum, minimum and the statistical distribution

  13. 《民报》阵营分野与辛亥革命前后政治舆论的媒介镜像%Min Bao Camp Distinction and the Media Mirror of Public Opinion about Politics around the Revolution of 1911

    Institute of Scientific and Technical Information of China (English)

    王天根

    2012-01-01

    辛亥革命前后的政治舆论动员涉及“革命”学理论证。《民报》作为话语系统,其对革命的表述策略在政治宣传中有集中的表现。《民报》被查禁本属媒介事件,引发巨大反响,并迅速演化成政治事件。查禁前后的政治语境及其相联系的舆论氛围尤其值得重视。章太炎主持下的《民报》逐步改变了早期激进与和缓的折中的办报路线,益发地偏左。这涉及革命阵营内部老同盟会与原光复会之间的分野,特别是孙中山与章太炎之间的矛盾。后来者常据此将《民报》停刊完全归结革命思想分歧的产物,实际上,《民报》的停刊有着更为广阔的政治背景,它关联世界范围内远东政治格局的变迁。面对中关、中日、关日关系联动中的利益抉择,为避免将清延推向关国的怀抱,日本对清廷及革命者采取了均势外交策略。这亦是《民报》第二十四号暂时停刊的重要原委。《民报》被查禁事件发生在辛亥革命前夕,《民报》被查禁的历程及局内、局外人解读,反映出革命元首与政治资源获取、日本外交策略及其对华政治舆论控制等种种联动关系造成复杂纠结的历史变数。%Around the Revolution of 1911, the mobilization of public opinion about politics was related to the revolutionary theory. Min Bao, as a language system, its representation of the revolution in political propaganda strategy had focused on performance. Its prohibition triggering a huge response, and quickly evolved into a political event. The political context and its associated atmosphere of public opinion around the prohibition should be particularly noteworthy. Min Bao which led by Zhang Taiyan use a compromised way to express their opinion, but now they gradually changed their routes of the early radical and moderate compromise the newspaper route, all the more to left. This involves the revolutionary camp

  14. 标准通道与微通道经皮肾镜治疗感染性肾结石的对比研究%A comparative study of standard percutaneous nephrolithotomy and Min - percutaneous nephrolithotomy in treatment of renal struvite calculi

    Institute of Scientific and Technical Information of China (English)

    张林林; 吴卫真; 朱李兵; 朱凌峰; 王栋; 谢星; 林若飞

    2011-01-01

    目的 研究经皮肾镜标准通道与微通道碎石术治疗感染性肾结石疗效和安全性.方法 回顾分析2006 年1 月至2010 年6月我院138例(149例次)应用经皮肾镜术治疗肾脏感染性结石患者的资料.其中采用标准通道83例次,采用微通道66例次.对两组患者结石清除率、手术时间和手术并发症等指标进行比较分析.结果 两组患者均分别成功建立24F和18F肾穿刺通道.两组清石率比较:标准通道组与微通道组Ⅰ期单通道结石清除率分别为71.08%(59/83)、48.48%(32/66),P0.05;两组术后血细菌培养阳性分别为18例、24例,P 39℃)分别为10例、13例,P>0.05.结论 标准通道经皮肾镜术具有手术时间短、清石效率高、低压灌注及感染率低,术后菌血症发生率低等优点,在处理感染性肾结石方面优于微小通道经皮肾镜术.%Objective To compare the efficacy and safety of standard percutaneous nephrolithotomy( S - PCNL) and Min - percutaneous nephrolithotomy( MI - PCNL) in the treatment of renal struvite calculi. Methods Clinical data of 138 patients with renal struvite calculi who underwent PCNL from January 2006 to June 2010 in our hospital were retrospectively analyzed. S - PCNL and MI - PCNL were performed in 83 and 66 cases respectively. Stone -free rate ,operative time and complications were compared. Results 24F and 18F percutaneous renal assess were successfully established in the S - PCNL and MI - PCNL groups respectively. The single channel stone- free rate at phase Ⅰ was 71.08% (59/83)in the S- PCNL group and 48.48% ( 32/66 ) in the MI - PCNL group with difference being significant ( P < 0. 05 ). The total stone - free rate at phase Ⅰ was 80.72% ( 67/83 ) in the S - PCNL group and 60.60% ( 40/66 ) in the MI - PCNL group(P <0.05 ). The operative time was(95 ± 16) min in the S - PCNL group and( 120 ±15 )min in the MI- PCNL group( P <0.05 ). Mean blood loss in the operation was( 136 ± 9

  15. OFDMA系统基于QoS保证和最大最小公平性准则下的动态资源分配%Dynamic Resource Allocation for QoS-aware OFDMA Systems with Max-min Fairness Constraint

    Institute of Scientific and Technical Information of China (English)

    陈瑾平; 杨绿溪

    2011-01-01

    Orthogonal frequency division multiple access (OFDMA) is a promising candidate for high-speed wireless communication networks, due to its high spectral efficiency and resistance to multipath fading. Fairness and efficiency are two crucial issues in resource allocation for OFDMA wireless networks. The objective of this paper is to provide the required Quality-of-Service ( QoS) of the guaranteed performance users with given data rate requirements and to maximize the capacity of the best effort users while maintaining max-min fairness among them. The resource allocation issue in OFDMA systems is the joint optimization of subcarrier assignment and power allocation subject to a total network power constraint. It is a mixed discrete programming issue known to be NP-hard and obtaining an exhaustive search allocation is computationally very expensive. In this paper, the algorithm to solve this non-convex problem is proposed by Lagrangian dual relaxation and obtains the optimal dual point based on the modified ellipsoid method. The algorithm has the polynomial complexity linear with the number of subcarriers. Numerical results show that the proposed algorithm can be near optimal to the globally optimal solutions in terms of both QoS satisfaction and services max-min fairness.%正交频分多址(OFDMA)技术以其更高的频谱效率和抗多径衰落特性成为高速无线通信网络的候选标准.如何兼顾效率和公平性是OFDMA系统资源分配亟待解决的问题.本文研究了OFDMA系统中的无线资源分配问题,既要保证QoS用户的最小速率要求,同时“尽力而为”用户之间必须满足最小速率最大化公平性(max-min fairness)准则;该资源分配问题可以表述为一个系统总功率约束下的子载波分配和功率控制的混合离散型优化模型,这是难解的NP-hard问题,穷举搜索的代价是极其巨大的.针对该非凸模型,本文设计一个拉格朗日松弛的优化算法,该算法中采用修正

  16. 浙闽木拱桥类型学研究——以桥板苗系统为视角%Typological study on timber arch bridges in Zhe-Min provinces:with focus on bridge-deck-beam-system

    Institute of Scientific and Technical Information of China (English)

    刘妍

    2011-01-01

    The timber arch bridge in Zhejiang (Zhe) and Fujian (Min) provinces is a unique beamweaving-arch structure, and has a close genetic relationship with the Rainbow Bridge in the famous Song-dynasty painting the scene of the upriver at pure brightness festival ". By a study of typological analysis focusing on the timber structure, it is pointed out in this paper that there is an important distinction between the timber arch bridge in Zhe-Min provinces and the Rainbow Bridge over the Bian River. Throughout the development of the former, the bridge-deck-beam-system has hold a significant role, and should be seen as the third system aside from the first and second systems, viz. the tri-segment arch, and the penta-segment arch. The signification in the bridgedeck-beam-system of timber arch bridge in Zhe-Min provinces includes: functionally, it provides a gentle-sloped floor for the bridge-deck; structurally, it shares the load of the arch, and serves the structural stability; typologically, the method of the combination of the bridge-deck-beam-system and the arch system provides an important factor of depicting the development of the typology of timber bridges. And an essential character of the evolvement of the structure of timber bridges is structure addition and simplification. The simplification and stabilization are the main motivation in the evolvement of timber arch bridges.%浙闽木拱桥独特的编梁拱形结构与汴水虹桥有着密切的关系.对木拱桥结构的类型学分析结果表明,浙闽木拱桥与汴水虹桥的一个重要区别在于,在浙闽木拱桥的发展历程中,桥板苗系统自始至终占有重要的地位,可视作三节苗、五节苗体系之外的第三套体系.浙闽木拱桥桥板苗系统的重要性体现在使用功能上,可保证桥面的平缓;在结构上有效地分担了拱架荷载,并保证结构的稳定;在类型学上,桥板苗系统与编织拱系统的结合方式的多样做法,是探讨木拱桥类型学

  17. Influence de la nature chimique et minéralogique des argiles et du processus de fabrication sur la qualité des carreaux céramiques Influence of chemical and mineralogical nature of clay and manufacturing process on the quality of ceramic tiles

    Directory of Open Access Journals (Sweden)

    Sadik C.

    2012-09-01

    Full Text Available La présente étude correspond à une approche pluridisciplinaire menée en étroite collaboration entre des géologues, des chimistes et des industriels de la céramique. Les résultats confirment l’étroite relation existante entre la composition des argiles et la qualité du produit céramique final. Les briquettes obtenues, dans les mêmes conditions, à partir de deux argiles marocaines assez différentes du point de vue chimique et minéralogique, présentent des caractéristiques technologiques bien distinctes. l’utilisation d’adjuvants minéraux, bien sélectionnés, contribue à l’équilibrage des argiles brutes et conduit à une nette amélioration de la qualité du produit céramique, notamment une réduction de leur retrait à la cuisson et une augmentation de leur résistance à la flexion. Concernant l’effet du processus de fabrication, l’application de l’engobe et de l’émail, s’avère être à l’origine de bombement des carreaux lors de la cuisson, en raison vraisemblablement de la différence des coefficients de dilatation des deux milieux argile et émail. This study is conducted in a multidisciplinary collaboration between geologists, chemists and industrial ceramics. The results confirm the close ralatioship existing between the composition of clays and quality of the finished ceramic pieces. The obtained specimens, under the same conditions, from two moroccan clays that are different on the chimico-mineralogical point of view, present distinct technological characteristics. The use of well selected mineral adjuvants, contributes to the balancing of raw clays and leads to a marked improvement in the quality of the ceramic product, including a reduction on their firing shrinkage and an increase of flexural strength. Concerning the effect of the manufacturing process, the application of the glaze, turns out to be the cause of bulging tiles during firing, probably because of the difference in thermal

  18. 相关性分析和最大最小蚁群算法用于脉搏信号的情感识别%Affective Recognition from Pulse Signal Using Correlation Analysis and Max-Min Ant Colony Algorithm

    Institute of Scientific and Technical Information of China (English)

    陈红; 刘光远; 赖祥伟

    2012-01-01

    For the affective recognition from pulse signal,a new approach was presented, which combined correlation a-nalysis and max-min ant colony algorithm. The effective feature subset which can identify the affective recognition model with better performance was found. Firstly, sequential backward selection(SBS) was used for sorting the original features. Secondly, the linear correlation coefficient was presented for calculating the correlation between features, and some features were removed which had greater correlation according to the result of sorting. Finally,max-min ant colony algorithm realized feature selection which searched for an optimal subset based on the compact feature subset,and combined with Fisher classifier to finish classification of six emotions which include happiness,surprise,disgust,grief,anger and fear. The experiments show that the proposed approach can find the more stable and effective feature subset from the original feature set, and establish effective affective recognition model.%针对脉搏信号的情感识别问题,提出了一种相关性分析和最大最小蚁群算法相结合的方法,找出了对情感识别模型构建具有较好性能的稳定特征子集.首先将原始特征用序列后向选择(SBS)方法排序,然后利用线性相关系数分析法计算特征间的相关度,并根据排序结果去除部分相关度较大的特征,最后针对筛选后的特征子集用最大最小蚁群算法进行特征选择,并结合Fisher分类器对高兴、惊奇、厌恶、悲伤、愤怒和恐惧6种情感进行分类.实验结果表明,该方法能在原始特征集合中找出更稳定有效的特征子集,从而建立起有效的情感识别模型.

  19. Bacterial leaching kinetics for copper dissolution from a lowgrade Indian chalcopyrite ore Cinética de lixiviação por bactéria para a dissolução de cobre de um minério de calcopirita de baixo teor encontrado na Índia

    Directory of Open Access Journals (Sweden)

    Abhilash

    2013-06-01

    Full Text Available Bio-leaching of copper (0.3% from a low grade Indian chalcopyrite ore of Malanjkhand copper mines, using a native mesophilic isolate predominantly Acidithiobacillus ferrooxidans (A.ferrooxidans, is reported. A bio-recovery of 72% Cu was recorded in the presence of this culture (not adapted, which increased to 75% with an ore adapted culture after 35 days at 35ºC and pH 2.0 with Biolixiviação de cobre (0,3% de um minério de calcopirita de baixo teor, extraído em minas de Malanjkhand, usando um isolador mesofílico nativo, predominante Acidithiobacillus ferrooxidans (A.ferrooxidans, é apresentada. Uma biorrecuperação de 72% Cu foi registrada na presença dessa cultura (não adaptada, que aumentou para 75% com a cultura do minério adaptado e cultivado por 35 dias ao 35ºC e pH 2,0, com <50um partículas. Os dados cinemáticos mostraram mais adequados para o modelo básico de encolhimento controlado por difusão, exibindo lotes lineares de [1- 2/3X- (1-X2/3] vs temp (X - fração lixiviada. Parece que o papel da bactéria, no processo, é o de converter o íon ferroso para o estado férrico, que oxida a calcopirita para poder dissolver o cobre, mantendo o alto potencial redoxante. O valor da energia de ativação (E foi calculado em 96 e 108 kJ/mol, para as culturas sem e com adaptação, respectivamente, com temperaturas entre 25-35ºC. Esse mecanismo de lixiviação foi corroborado por identificação fásica XR D e em estudos da resídua da lixiviação.

  20. Caracterização tecnológica dos tipos de minério de fosfato do Complexo Alcalino de Salitre, MG - Área Fosfertil Technological characterization of phosphate ore types from the Salitre Alkaline Complex, MG - Fosfertil Area

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    Daniel Uliana

    2009-12-01

    Full Text Available São apresentados os resultados de caracterização tecnológica de seis tipos de minério fosfático provenientes do Complexo de Salitre, tendo em vista definir a composição mineralógica das amostras e as características inerentes à apatita e ao minério relevantes para o beneficiamento mineral. Os teores de P2O5 variam de 9 a 25% e a proporção de finos (-0,020 mm situa-se entre 20 e 34% em massa com perdas associadas de 17 a 22% do total de P2O5 presente. As amostras são compostas, essencialmente, por apatita, oxi-hidróxidos de ferro, ilmenita, argilominerais, carbonatos, quartzo, piroxênio, perovskita, alumino-fosfatos e outros minerais acessórios, variando apenas suas proporções relativas. Verificou-se que a apatita ocorre, predominantemente, liberada já abaixo de 0,21 mm, com superfície límpida a fracamente impregnada por oxi-hidróxidos de ferro; a parcela altamente impregnada (não flotável varia de 6 a 9%. Do total de fósforo contido nas amostras, mais de 97% ocorre sob a forma de apatita (acima de 0,020 mm e a recuperação potencial estimada de P2O5 na etapa de flotação é superior a 90% (recuperação global estimada entre 71-76%.The present study was carried out on six different ore types from the Salitre Alkaline Complex aiming to determine their mineralogical composition and the major features that are relevant in the mineral processing. The P2O5 grades vary from 9 to 25%. The slime content (-0,020 mm varies between 20 and 34% (w/w and carries 17-22% of the P2O5 content. The samples essentially consist of apatite, iron oxi-hydroxides, ilmenite, clayminerals, carbonate, quartz, pyroxene, perovskite, secondary phosphates and other minor accessory minerals. Below 0.21 mm, apatite essentially occurs in free particles showing a clean surface or a weak coating of iron oxi-hydroxides; the highly covered apatite (not recoverable by flotation varies from 6 to 9%. In the deslimed fraction (above 0.020 mm more than 97% of

  1. Hotel (Hotel star rating) upgrading Project Method and Model --Case study: Fujian MinJiang Hotel upgrading Project%酒店升星改造的设计方法与模式——以福建省闽江饭店升星改造工程为例

    Institute of Scientific and Technical Information of China (English)

    何嘉

    2012-01-01

    Hotel (hotel star rating) upgrading is a systematic project, including comprehensive planning, novel style, aesthetic ap- pearance, technical support and professional management, etc. The implementation process is a systematic investigation, rational analysis, found the problem and problem solving process. The designer explored and analysed the method and model of hotel up grading and interior design through his experience in Hotel upgrading project of FuJian MinJiang Hotel and delivered the concept in this article.%酒店升星改造是一项系统工程,包括全面的规划,新颖的风格,审美的表象,配套的技术和专业的管理等。实施过程是一个系统的调查研究,理性分析,发现问题,解决问题的过程。本文通过对自己设计的福建省闽江饭店升星改造工程这一实际案例的分析,探寻酒店升星改造的室内设计方法与模式。

  2. Study on ecological translation of"Sun Tzu's art of war"--English translation of Min Fude's works%《孙子兵法》的生态翻译英译研究--闵福德的英译作品

    Institute of Scientific and Technical Information of China (English)

    张鸿

    2013-01-01

    Ecology, combines with other disciplines, translation adapt to the cultural environment, forming the ecological translation. Eco-translatology is the translation of an ecological perspective, the essence is the translator to translate to adapt to the ecological environment. It provides a theoretical tool for the translation of"Sun Tzu's art of war", the translators to make adaptation and selection. English translation of works of Min Fude is the paradigm to use ecological translation in"Sun Tzu's art of war".%生态学与其他学科结合,翻译适应了文化环境,就形成了生态翻译。生态翻译学是一种生态学视角的翻译研究,实质是译者为适应翻译生态环境做出的翻译。它为《孙子兵法》的英译研究提供了理论工具,译者在翻译环境中做出不同的适应和选择,适者生存,优胜劣汰。闵福德的英译作品是运用生态翻译于《孙子兵法》的范例。

  3. Future Recovery of Energy and Mineral Values from Organic-Rich Shales (Summary L'avenir de la production d'énergie et de la valeur minérale des schistes riches en matière organique (résumé

    Directory of Open Access Journals (Sweden)

    Park W. C.

    2006-10-01

    Full Text Available Oil shale deposits vary significantly in their geological nature and can represent enormous reserves of low grades ores for various minerals such as alumina, sodium carbonates, molybdenum, nickel, vanadium, and uranium. The treatment of these rocks for mineral values can be economically attractive when coupled with the production of synthetic oil. Mutually shared costs for extractinq the mineral values can be favorably affected by utilizing by-products from the oil shale retorting. These can include the residual char for a carbonaceous reductant or fuel, C02 for acidification, or lime and soda ash for caustic. Conversely, an inappropriate choice of oil shale retorting conditions can substantially lower subsequent recovery of mineral values from the spent shale. The proceeding considerations will be discussed for several oil shale deposits including: 1. The Green River formation in the mid-western United States which is not only oil rich but also represents a nearly inexhaustible domestic supply of alumina and sodium carbonates and 2. The block shale of Julia Creek, Queensland, Australia, the Devonian Chattanooga shale in the United States, the Cambrian Kulm shale in Sweden, the Permian Lodeve shale in southern France, and the Paleozoic shales from Korea and USSR for energy and metal values such as molybdenum, nickel, vanadium, and uranium. La nature géologique des dépôts de schistes à huile est très variée ; ces schistes peuvent représenter des réserves énormes de minerais à faible teneur de métaux tels que l'aluminium, le molybdène, le nickel, le vanadium, l'uranium, sans oublier le carbonate de sodium. Le traitement de ces roches pour leur valeur minérale peut être attractif économiquement s'il est associé à la production d'huile synthétique. La répartition des coûts d'extraction des métaux peut être favorablement affectée en utilisant les sous-produits du traitement des schistes à huile. Ceci peut comprendre le goudron

  4. 哲人目光和母性慈怀--郑敏20世纪40年代诗歌的独特性%Philosophical Vision and Maternal Love--The Uniqueness of Zheng Min ’s Poetry during the 1940s

    Institute of Scientific and Technical Information of China (English)

    邱景华

    2016-01-01

    It is generally agreed that Zheng Min has inherited FengZhi and Rilke ’s tradition of mixing philosophy into poetry and uplifted the tradition to a metaphysical height. But ,this simplified generalization fails to reveal Zheng ’s uniqueness and richness.Since she was a student ,she has never tried to confine herself to the ivory tower and stay away from realities;on the contrary ,the internationalized education of and the wisdom of the great academic masters at South⁃western Associated University cultivated young Zheng ’s concern about the destiny of the human beings and her philo⁃sophical vision. After graduation ,her job of international news translation gave her opportunities to observe and reflect on important historical events happening in the world and to give her response in the form of poetry. Her sonnets ,which were filled with philosophical vision ,maternal love ,and feminine feelings and imagination ,constitutes her poetic uniqueness during the 1940s. Careful perusal of Zheng ’s sonnets will help readers understand the process of the forma⁃tion and development of their uniqueness. Zheng ’s early poems ,as they did not reflect the Anti-Japanese War ,were not quite accepted and appreciated by her contemporaries ,but their concern about human beings ’common destiny and expectation of world civilization have been gaining the recognition of history and time. Zheng Min herself is also a well-deserved poet prophet.%诗界比较普遍的观点认为:郑敏师承冯至和里尔克诗歌与哲学相融合的传统,并达到形而上的高度。但这过于简化的概括,很难揭示郑敏诗作的独特性和丰富性。其实,从学生时代起,郑敏并没有逃避现实,躲进象牙塔。恰恰相反,西南联大的世界性教育和哲学系大师们的智慧,培养了青年郑敏对人类命运的关注和哲人目光。毕业后所从事的国际时事翻译,又使她得以用哲学眼光观察和思考世界所发生的

  5. Impact of Mineralogy and Diagenesis on Reservoir Quality of the Lower Cretaceous Upper Mannville Formation (Alberta, Canada Impact de la minéralogie et de la diagenèse sur la qualité des réservoirs de la Formation Mannville Supérieur, Crétacé Inférieur (Alberta, Canada

    Directory of Open Access Journals (Sweden)

    Deschamps R.

    2012-02-01

    space where the clay content is reduced. Additional SEM and XRD analyses allowed characterizing and quantifying more accurately the different mineralogical phases occluding the porous network. The characterization of both mineralogy and petrophysical properties gives useful keys to locate the diagenetic phases laterally and vertically, and to predict the petrophysical properties distribution. La Formation Mannville Supérieur du Crétacé Inférieur d’Ouest-Central Alberta a été intensivement forée les précédentes décennies par des puits visant des réservoirs plus profonds. Cependant, les données de production dans ce secteur suggèrent que des volumes significatifs de gaz soient présents dans les réservoirs tant conventionnels que non conventionnels (“tight reservoirs” de cette formation. Les réservoirs de la Formation Mannville Supérieur d’Ouest-Central Alberta sont constitués de grès fluviatiles remplissant des vallées incisées. Ces grès présentent une minéralogie complexe, avec des quantités variables de quartz, de feldspaths, de minéraux argileux et des fragments de roche. Ils ont été soumis à une histoire diagénétique complexe et la paragenèse qui en résulte a eu un impact sur leurs propriétés réservoirs. Par conséquent, les hétérogénéités dans les propriétés réservoirs induisent des risques significatifs en termes d’exploration et de production de ces réservoirs. Nous présentons dans cet article les résultats de l’étude diagénétique, effectuée dans un cadre stratigraphique bien contraint, visant à comprendre l’impact de la minéralogie et de la diagenèse sur l’évolution de la qualité des réservoirs. Soixante et onze échantillons prélevés sur huit puits ont permis de réaliser une analyse pétrographique et proposer une séquence paragénétique. Quatre événements diagénétiques principaux ont été identifiés et sont liés à l’enfouissement du bassin : – coating d’argile autour des

  6. 从地域文化走向全国文化——试论闽都文化对中国文化的贡献%From Regional Culture to National Culture ---On the Contribution of Min Capital Culture to Chinese Culture

    Institute of Scientific and Technical Information of China (English)

    赵君尧

    2012-01-01

    纵观中华文明的历史,中国文化的生命力正在于不断的丰富和发展中,在于它的多元性和包容性。福州作为历代福建省首府,其政治、经济、文化、社会等多方面,对全省起到了引领和辐射作用,并形成独具地域特色的闽都文化。闽都文化对中华文化的主要贡献,一个是在宋代,开闽学先河,承理学南传、成理学重镇。另一个是在近代,禁烟拉开中国近代史序幕,《瀛环志略》迎来中国社会启蒙时代,《天演论》开启中华民族心智,有力地推动中国近代社会向规代社会的转型。%In the history of Chinese civilization, Chinese culture's vitality lies in its unceasing enrichment and development, as well as its diversity and inclusiveness. As the ancient capital city of Fujian province, Fuzhou has played a leading and radiative role in the political, economic, cultural, social, and other aspects. At the same time, a unique Min culture with distinguishing regional features has been formed in Fuzhou. One of the main contri- butions of Capital culture to the Chinese culture is the beginning of Minzhong School, and tbrming the Neo-Confu- eianism center in Song Dynasty. Another is the Banning Smoking Movement that opened the prologue of Chinese modem history. The Historical Geography of the World ushered in Chinese social enlightenment age. Evolution Theo- ry opened the national mind, and impelled Chinese social transition to a modem societv powerfully.

  7. 中国近代教会大学华人校长的教育理念述评--以华中大学韦卓民先生为例%Comment on the Education Idea of Modern Christian CoIIege’s Chinese President---Case on Wei Zhuo-min of Huachung University

    Institute of Scientific and Technical Information of China (English)

    贺鹏丽; 申国昌

    2015-01-01

    Wei Zhuo‐min was the famous educator , phiIosopher and patriot , dedicated his Iife to bridging East and West and the founding and deveIopment of Huachung University , so Wei had unique thoughts higher education . As the first Chinese president of Huachung University , Wei aIways insisted on the aim of the coIIeges , was to bring up taIented person for country , focused on the quaIity of teaching management system , student‐centered vaIue orientation and the university spirit which was democracy ,responsibIe and Iaw‐abiding , that Huachung University became more vitaIity and distinctive . Wei had unique educationaI idea and pIentifuI educationaI practice , which had a strong practicaI significance and the enIightenment for the reform and deveIopment of higher education nowadays .%韦卓民先生是中国近现代著名的教育家、哲学家和爱国者,他博学多才,学贯中西,以矢志不渝的奉献精神致力于华中大学的创办和发展,形成了自身独特的高等教育思想。在私立武昌华中大学二十多年的校长任内,他始终坚持“兴学育才,蔚国所用”的办学宗旨、“重质不重量”的教学管理制度、“以生为本”的价值取向及“民主、负责、守法”的大学精神,培养出一批又一批优秀人才,将华中大学这所教会大学办得相当有活力并颇具特色。作为一名虔诚的基督教爱国者、教育家,韦卓民先生独特的办学理念和丰富的办学实践,对当今我国高等教育的改革与发展有着较大的现实意义及启示。

  8. Species Composition and Distribution Characteristics of Phytoplankton in Northern Sea of Fujian, China During Withdraw of Zhe-Min Coastal Current%福建北部海域浙闽沿岸流消亡期浮游植物的种类组成与分布特征

    Institute of Scientific and Technical Information of China (English)

    林更铭; 杨清良; 王雨; 林维含

    2012-01-01

    Based on the survey data of net-phytoplankton samples and simultaneously physic-chemical parameters in northern sea of Fujian, China in April 2009, the species composition, distribution characteristics of phytoplankton and their relationship to environmental factors were analyzed. Eighty-five species belonging to 3 phyla were recorded. Among them most were eurythermal species (47.06%), the next were warm-water species (36.47%) and temperate species only accounted for 7.06%. The average of phytoplankton abundance was 137.89x104 cells m-3 increasing from nearshore waters to the offshore and from the north to the south. Bray-Curtis similarity clusters showed that the phytoplankton community could be divided into two groups. The first group was inshore stations in the north of the Minjiang River, dominated by neritic species. The second cluster was offshore stations in the outer part of the Sansha Bay and in the south of the Minjiang River, dominated by hyperhaline species, eurythermal and euryhaline species. Principal components analysis (PCA) indicated that currents played an important role in the distribution of the phytoplankton in the study area, and the phytoplankton abundance was significantly positive correlation with water temperature and salinity. It suggested that the Zhe-Min coastal current had withdrew from the area during the survey time, and the phytoplankton distribution pattern was mainly influenced by the Taiwan warm current. Phytoplankton abundance and distribution were similar to those reported previously. However, the phytoplankton community structures showed quite differently. Besides neritic species and eurythermal and euryhaline species, oceanic eurythermal species was one of the dominant species. The diversity index and evenness index were relatively high compared with other studies, which might be the results of wax and wane of the Zhe-Min coastal current caused by prevailing NE monsoon. Fig 9, Tab 5, Ref 28, App 1%根据2009年4

  9. Géochimie minérale de sédiments à faciès black-shales, Crétacé moyen de l'Atlantique Nord, sites DSDP 386 et 391 Mineral Geochemistry of Black Shales from the Mid-Cretaceous of the North Atlantic, Dsdp Sites 386 and 391

    Directory of Open Access Journals (Sweden)

    Brosse E.

    2006-11-01

    Full Text Available L'analyse chimique de 154 échantillons d'âge Aptien à Turonien, pour l'essentiel des argilites, en provenance des sites DSDP-IPOD 386 (situé sur la ride des Bermudes et 391 (localisé au pied de la marge américaine, met en évidence, d'une manière indépendante des lithofaciès et des compositions minéralogiques, un certain nombre d'influences enregistrées par les sédiments : - influences du potentiel d'oxydo-réduction : enrichissements en Fe et Mn des dépôts oxydés ; en V, Ni, Co, Zn, Cu des sédiments réduits, et notamment des argilites pyriteuses et très carbonées déposées pendant l'événement E2à la limite Cénomanien-Turonien ; - influences du détritisme terrigène, avec trois indices particulièrement intéressants : les comportements comparés des alcalins (Na et K, la teneur en Ga des smectites, et le rapport D = AI/(AI + Fe + Mn ; - influences du volcanisme, soit sous forme de pyroclastes (enrichissement en Ti et Cr, soit sous forme ionique par l'intermédiaire de solutions interstitielles circulantes (enrichissement en Fe, Mn, Ba, Ni, Co, Cu, Pb ; - influence du taux de sédimentation, mise en évidence grâce à Cr. Les résultats obtenus apportent des précisions intéressantes sur l'évolution dans l'espace et dans le temps des milieux de dépôt et de diagenèse. Etant donné, par ailleurs, que les sédiments étudiés se sont déposés dans des conditions de milieux déjà connues grâce aux approches de la sédimentologie, de la minéralogie et de la géochimie organique, la reconnaissance des caractéristiques géochimiques de tels milieux pourra probablement aider à la reconstitution des conditions de dépôt pour des séries d'âges et de faciès comparables, mais transformées par un métamorphisme isochimique, telles les schistes lustrés alpins. One hundred fifty-four samples of Aptian to Turonian black-shales from various lithofacies have been selected for chemical analysis from DSDP sites 386

  10. Temperature sensitivity of soil methane production potential in different marsh vegetation zones in the Min River estuary%闽江口不同沼泽植被带土壤甲烷产生潜力的温度敏感性

    Institute of Scientific and Technical Information of China (English)

    杨平; 何清华; 仝川

    2015-01-01

    2012年2月采集闽江河口鳝鱼滩短叶茳芏(Cyperus malaccensis),芦苇(Phragmites australis)和互花米草(Scirpus alterniflora)3个典型潮汐沼泽植被带0~30cm(间隔5cm)土壤样品,在不同温度(10,20和30℃)进行15d室内厌氧培养实验,探讨河口区不同沼泽植被带土壤甲烷产生潜力及其温度敏感性(Q10值)的特征.结果表明,指数模型较好地拟合不同沼泽植被带土壤甲烷产生与温度的相关关系;温度由10℃升至20℃时,3个沼泽植被带土壤甲烷产生潜力 Q10值的均值分别为5.04,14.92和14.81,最大值均在培养期间的第13~15d 分别出现于10~15cm,15~20cm和20~25cm三个土层;温度由20℃升至30℃时,3个沼泽植被带土壤甲烷产生潜力Q10值的均值分别为3.56,4.99和3.43,最大值分别在培养期间的第4~6d,第4~6d和第7~9d出现于0~5cm,0~5cm和15~20cm三个土层;植被类型和土壤深度对甲烷产生潜力及Q10值均具有显著的影响(P<0.05).%Quantifying response of soil methane production potential to temperature change in different wetland vegetation are vital to accurately evaluate effect of climate change on wetland ecosystem carbon balance. Soil samples at a depth of 0~30cm (5cm interval) from three typical tidal marsh ecosystems dominated byCyperus malaccensis, Phragmites australis andSpartina alterniflora, respectively, in the Min River estuary were collected in February 2012, and soil methane production potentials were determined using anaerobic incubation method. The results showed that there is an exponential correlation between methane production potential and soil temperature. The averagedQ10 value of three marsh vegetation zones were 5.04, 14.92, 14.81, and 3.56, 4.99, 3.43, respectively, with temperature rasing from 10 to 20℃ and from 20 to 30℃. Vegetation type, incubation temperature and soil depth had significant effects on the methane production potential andQ10 value (P<0.05).

  11. Injury Sites and Radiologic Features of 60 Patients with Severe Earthquake Trauma in Min-Zhang Earthquake in Gansu Province, 2013%2013年甘肃省岷县、漳县60例地震重症伤员受伤部位及其影像学特点

    Institute of Scientific and Technical Information of China (English)

    雷军强; 张沥; 窦郁; 姚宏; 杨玉琴; 王闻奇; 杨克虎

    2014-01-01

    Objective To analyze injury sites and radiologic features of 60 patients with severe earthquake trauma in Min-Zhang earthquake in 2013.Methods We retrospectively collected clinical data of 60 patients with severe earthquake trauma who were sent to major hospitals in Lanzhou city within 7 days after the earthquake.The software of Excel was used to input and analyze clinical data.Results Among 60 patients with severe earthquake trauma,there were 20 cases with single-site injury and 40 cases with multi-site injury,amounting to 120 injury sites.A total of 41 cases were injured in the limbs,involving 53 parts of fracture,of which,11 cases were injured in the upper limbs (12 sites) and 34 cases in the lower limbs (41 sites).A total of 14 cases were injured in the skull (16 sites).13 cases were injured in the spine involving a total of 14 vertebrae,20 sites,of which,10 cases were accompanied by injuries in the brain and spinal cord.A total of 17 cases were injured in the chest,of which 6 cases were accompanied by rib fracture,amounting to 27 sites.A total of 7 cases were accompanied by visceral injury,involving four sites of the abdomen.Conclusion Multi-site and multi-organ injuries are the most after the earthquake,of which,limb fracture is frequently-seen and abdominal injuries are rare.Imaging examination is very useful in screening injuries caused by the earthquake and in treatment based on categorization.%目的 对2013年甘肃省岷县、漳县地震重症伤员的受伤部位及其影像学特点进行分析.方法 回顾性收集在地震发生7天内送往兰州市各大医院的岷县、漳县60例地震重症伤员的临床资料,采用Excel软件录入数据并进行分析.结果 60例地震伤员中,20例为单部位损伤,40例为多部位损伤,受伤部位共计120处.四肢伤41例,共53个部位骨折,其中上肢11例(12个部位),下肢34例(41个部位).头颅伤14例,共16个部位.脊柱伤13例,共累及14个椎体,20个部位,其中10例伴

  12. Raypex® 5’in Minör Çapın Belirlenmesindeki Doğruluğunun Ex Vivo Olarak Değerlendirilmesi Ex Vivo Evaluation Of The Accuracy Of Raypex® 5 In Determining The Minor Diameter

    Directory of Open Access Journals (Sweden)

    Nevin Kartal

    2011-05-01

    Full Text Available

    ÖZET

    Amaç: Bu ex vivo çalışmanın amacı, Raypex® 5 adlı elektronik apeks bulucunun minör çapın tespitindeki doğruluğunu değerlendirmektir.

    Gereç ve Yöntem: Çalışmada 40 adet çekilmiş üst kesici insan dişi kullanıldı. Operasyon mikroskobu altında X5 büyütmede eğe ucu, majör foramene kadar ilerletildi ve silikon stoper düzleştirilmiş koronal yüzeyde sabitlendi. Silikon stoper ve eğe ucu arasındaki mesafe ölçüldü ve referans kanal boyu (RKB olarak adlandırıldı. Daha sonra Raypex® 5 ile elektronik ölçümler alındı ve silikon stoperle eğe ucu arasındaki mesafe ölçülerek bu değer elektronik kanal boyu (EKB olarak adlandırıldı. Ardından kanal aleti, RKB’de akışkan kompozitle dişin koronalinde sabitlendi. Kök kanallarının apikal 4 mm’leri elmas frezlerle ekspoze edildikten sonra X64 büyütmede stereomikroskop altında incelendi ve dijital fotoğrafları alındı. Tüm görüntüler

  13. 海口闽语量词“目”“节”“xak5”理据与用法浅析--兼论与琼地少数民族语言、现代汉语比较%An Analysis of the Motivation and Usage of Qualifiers“Mu”,“Jie”,“xak5”in Min Dialect in Haikou

    Institute of Scientific and Technical Information of China (English)

    李清桓; 邹岚

    2015-01-01

    The qualifiers “mu”,“jie”,“xak5”in Min dialect in Haikou are used to measure the length of segments or things,but the motivations and usages of each are different.“Mu”is the qualifier in Min dialect used to describe the characteristics of things.With the influence of the qualifier “jie”,it is motivated by the metaphoric mechanism and the law of parallel-derived words,used to measure things with knurs,and its length is integral multiple of “knur”;while “j ie”is used to measure things with relatively definite length measurement;and“xak5”originates from the Dong-Tai language family and the conversion of verbs with the corresponding “segment”meaning,which is used to measure things with any length.%海口闽语量词“目”、“节”、“xak5”能用来计量分段物或事物的长度,但三者产生的理据和用法各有不同。“目”是闽语特征量词,产生的理据是在“节”的影响下通过隐喻机制和词汇平行衍生规律的促动而形成,用来计量具有“结节”之物,且长度是“结节”的整数倍;“节”则用来计量长度相对确定的事物;“xak5”是借自侗台语族的量词,由侗台语族相应的、具有“断”语义的动词转类而成,用来计量任意长短的事物。

  14. The robust min-max newsvendor problem with balking under a service level constraint

    Directory of Open Access Journals (Sweden)

    Taesu Cheong

    2013-11-01

    Full Text Available In this paper we study an extension of a classic newsvendor model with balking under a service-level constraint. We also relax the assumption that the demand distribution is fully available to a decision-maker; we assume that only the mean and variance of the demand distribution are known, and discuss the procedure for determining the optimal order quantity for the concomitant model. We further extend our base model to two different cases: (i when the fixed ordering cost is included, and (ii when yield is uncertain. We illustrate the solution procedures for each case with numerical examples. Moreover, we discuss the performance and robustness of the approach through randomly generated test instances, and perform a numerical sensitivity analysis to evaluate the impact of the changes of a targeted fill-rate and variances of a demand distribution.

  15. Increased variability in Apc(Min)/+ intestinal tissue can be measured with microultrasound.

    Science.gov (United States)

    Fatehullah, A; Sharma, S; Newton, I P; Langlands, A J; Lay, H; Nelson, S A; McMahon, R K; McIlvenny, N; Appleton, P L; Cochran, S; Näthke, I S

    2016-01-01

    Altered tissue structure is a feature of many disease states and is usually measured by microscopic methods, limiting analysis to small areas. Means to rapidly and quantitatively measure the structure and organisation of large tissue areas would represent a major advance not just for research but also in the clinic. Here, changes in tissue organisation that result from heterozygosity in Apc, a precancerous situation, are comprehensively measured using microultrasound and three-dimensional high-resolution microscopy. Despite its normal appearance in conventionally examined cross-sections, both approaches revealed a significant increase in the variability of tissue organisation in Apc heterozygous tissue. These changes preceded the formation of aberrant crypt foci or adenoma. Measuring these premalignant changes using microultrasound provides a potential means to detect microscopically abnormal regions in large tissue samples, independent of visual examination or biopsies. Not only does this provide a powerful tool for studying tissue structure in experimental settings, the ability to detect and monitor tissue changes by microultrasound could be developed into a powerful adjunct to screening endoscopy in the clinic. PMID:27406832

  16. Localization of placenta in scanning by /sup 113m/In radiopharmaceuticals

    Energy Technology Data Exchange (ETDEWEB)

    Cho, O.K.; Oh, K.K.; Park, C.Y.; Choi, B.S.; Ha, C.H.; Chung, S.O.; Kwak, H.M.

    1975-01-01

    Placenta previa is a common grave complication of late pregnancy, usually manifestated clinically by painless antenatal vaginal bleeding. Digital and rectal examinations are dangerous, due to the possibility that profuse hemorrhage from the vagina may result. Various radiological examinations have been performed in placenta previa for diagnosis and localization. However radioisotopic methods are superior due to safety, simplicity and a lower radiation dose, both fetal and maternal, compared to plain radiography. Among radiopharmaceuticals, In/sup 113m/ (transferrin for blood pool scan) is useful, giving more satisfactory results without any complications or untoward reactions.

  17. Deterministic separation of cancer cells from blood at 10 mL/min

    OpenAIRE

    Kevin Loutherback; Joseph D'Silva; Liyu Liu; Amy Wu; Austin, Robert H.; Sturm, James C.

    2012-01-01

    Circulating tumor cells (CTCs) and circulating clusters of cancer and stromal cells have been identified in the blood of patients with malignant cancer and can be used as a diagnostic for disease severity, assess the efficacy of different treatment strategies and possibly determine the eventual location of metastatic invasions for possible treatment. There is thus a critical need to isolate, propagate and characterize viable CTCs and clusters of cancer cells with their associated stroma cells...

  18. MODIS/AQUA MYD14 Thermal Anomalies & Fire 5-Min L2 Swath 1km

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — MODIS Thermal Anomalies/Fire products are primarily derived from MODIS 4- and 11-micrometer radiances. The fire detection strategy is based on absolute detection of...

  19. The MinK Framework: Developing Metrics for the Measurement of Individual Knowledge

    OpenAIRE

    Arisha, Amr; Ragab, Mohamed

    2013-01-01

    Knowledge is the currency of the current economy and a vital resource for the sustainability of performance quality in today’s knowledge intensive business environment. To avoid the detrimental consequences of knowledge loss, managers are urged to identify where knowledge stocks exist and how knowledge flows within their organisations by keying out wellsprings of knowledge among their employees. Although some studies have attempted to measure knowledge on an organisational level using differe...

  20. Definitive Mineralogical Analysis of Mars Analog Rocks Using the CheMin XRD/XRF Instrument

    Science.gov (United States)

    Blake, D. F.; Sarrazin, P.; Bish, D. L.; Feldman, S.; Chipera, S. J.; Vaniman, D. T.; Collins, S.

    2004-01-01

    Mineral identification is a critical component of Mars Astrobiological missions. Chemical or elemental data alone are not definitive because a single elemental or chemical composition or even a single bonding type can represent a range of substances or mineral assemblages. Minerals are defined as unique structural and compositional phases that occur naturally. There are about 15,000 minerals that have been described on Earth, all uniquely identifiable via diffraction methods. There are likely many minerals yet undiscovered on Earth, and likewise on Mars. If an unknown phase is identified on Mars, it can be fully characterized by structural (X-ray Diffraction, XRD) and elemental analysis (X-ray Fluorescence, XRF) without recourse to other data because XRD relies on the principles of atomic arrangement for its determinations. XRD is the principal means of identification and characterization of minerals on Earth.

  1. Dobbelary: Om van baie verloorders te maak en van min wenners?

    Directory of Open Access Journals (Sweden)

    D. P. Veldsman

    1993-08-01

    Full Text Available Gambling: Making losers of many and winners of few?The question of the desirability of legalising gambling in South Africa and the affirmative proposal by the Howard Commission Report (March 1993 to this extent, is critically addressed in this short paper. Gambling, being a game of chance - and certainly already a well established and favourite pastime in South Africa - invites an understanding of the element of chance.

  2. An Exact Solution to the Power Networks Security Index Problem and its Generalized Min Cut Formulation

    CERN Document Server

    Hendrickx, Julien; Jungers, Raphael; Sandberg, Henrik; Sou, Kin Cheong

    2012-01-01

    The resilience of Supervisory Control and Data Acquisition (SCADA) systems for electric power networks for certain cyber-attacks is considered. In particular, we study the robustness of the observability properties of the network to the loss of some measurements. It was recently shown, under the full measurement assumption, that the problem can be cast as a generalization of the minimum cut problem involving costly nodes. In this paper, we show that it can be reformulated as a standard minimum cut problem (without costly nodes) on a modified graph of proportional size. An important consequence of this result is that the observability problem can be solved efficiently. Our approach provides the first exact efficient algorithm for this problem. It is illustrated on a numerical example.

  3. Effect of slow deep breathing (6 breaths/min) on pulmonary function in healthy volunteers

    OpenAIRE

    Shravya Keerthi G, Hari Krishna Bandi, Suresh M, Mallikarjuna Reddy N

    2013-01-01

    We designed this study to test the hypothesis that whether 10 minutes of slow deep breathing have any effect on pulmonary function in healthy volunteers. The main objective was to study the immediate effect of slow deep breathing on Forced vital capacity (FVC), Forced expiratory volume in the first second (FEV1), Forced expiratory volume percent (FEV1/FVC%), Peak expiratory flow rate (PEFR), Forced expiratory flow 25-75%(FEF25-75%), Maximum voluntary ventilation (MVV), Slow vital capacity (SV...

  4. RoadRunner for Heterogeneous Web Pages Using Extended MinHash

    Directory of Open Access Journals (Sweden)

    A Suresh Babu

    2012-03-01

    Full Text Available The Internet presents large amount of useful information which is usually formatted for its users, which makes it hard to extract relevant data from diverse sources. Therefore, there is a significant need of robust, flexible Information Extraction (IE systems that transform the web pages into program friendly structures such as a relational database will become essential. IE produces structured data ready for post processing. Roadrunner will be used to extract information from template web pages. In this paper, we present novel algorithm for extracting templates from a large number of web documents which are generated from heterogeneous templates. The proposed system focuses on information extraction from heterogeneous web pages. We cluster the web documents based on the common template structures so that the template for each cluster is extracted simultaneously. The resultant clusters will be given as input to the Roadrunner system.

  5. GeMInA, Genomic Metadata for Infectious Agents, a geospatial surveillance pathogen database

    OpenAIRE

    Schriml, Lynn M.; Arze, Cesar; Nadendla, Suvarna; Ganapathy, Anu; Felix, Victor; Mahurkar, Anup; Phillippy, Katherine; Gussman, Aaron; Angiuoli, Sam; Ghedin, Elodie; White, Owen; Hall, Neil

    2009-01-01

    The Gemina system (http://gemina.igs.umaryland.edu) identifies, standardizes and integrates the outbreak metadata for the breadth of NIAID category A–C viral and bacterial pathogens, thereby providing an investigative and surveillance tool describing the Who [Host], What [Disease, Symptom], When [Date], Where [Location] and How [Pathogen, Environmental Source, Reservoir, Transmission Method] for each pathogen. The Gemina database will provide a greater understanding of the interactions of vir...

  6. Min-Max Latency Walks: Approximation Algorithms for Monitoring Vertex-Weighted Graphs

    CERN Document Server

    Alamdari, Soroush; Smith, Stephen L

    2012-01-01

    In this paper we consider the problem of planning a path for a robot to monitor a known set of features of interest in an environment. We represent the environment as a vertex- and edge-weighted graph, where vertices represent features or regions of interest. The edge weights give travel times between regions, and the vertex weights give the importance of each region. If the robot repeatedly performs a closed walk on the graph, then we can define the latency of a vertex to be the maximum time between visits to that vertex, weighted by the importance (vertex weight) of that vertex. Our goal in this paper is to find the closed walk that minimizes the maximum weighted latency of any vertex. We show that there does not always exist an optimal walk of polynomial size. We then prove that for any graph there exist a constant approximation walk of size O(n^2), where n is the number of vertices. We provide two approximation algorithms; an O(log n)-approximation and an O(log \\rho)-approximation, where \\rho is the ratio...

  7. Muscle Synergies of Untrained Subjects during 6 min Maximal Rowing on Slides and Fixed Ergometer

    Directory of Open Access Journals (Sweden)

    Shazlin Shaharudin

    2014-12-01

    Full Text Available The slides ergometer (SE was an improvisation from fixed ergometer (FE to bridge the gap of mechanics between ergometer rowing and on-water rowing. The specific mechanical constraints of these two types of ergometers may affect the pattern of muscle recruitment, coordination and adaptation. The main purpose of this study was to evaluate the muscle synergy during 6 minutes maximal rowing on slides (SE and fixed ergometers (FE. The laterality of muscle synergy was also examined. Surface electromyography activity, power output, heart rate, stroke length and stroke rate were analyzed from nine physically active subjects to assess the rowing performance. Physically active subjects, who were not specifically trained in rowing, were chosen to exclude the training effect on muscle synergy. Principal component analysis (PCA with varimax rotation was applied to extract muscle synergy. Three muscle synergies were sufficient to explain the majority of variance in SE (94.4 ± 2.2 % and FE (92.8 ± 1.7 %. Subjects covered more rowing distance, exerted greater power output and attained higher maximal heart rate during rowing on SE than on FE. The results proved the flexibility of muscle synergy to adapt to the mechanical constraints. Rowing on SE emphasized on bi-articular muscles contrary to rowing on FE which relied on cumulative effect of trunk and upper limb muscles during propulsive phase.

  8. Hukm Naql A'da'i Mahdur al-Dam min Manzur Islami

    Directory of Open Access Journals (Sweden)

    Ahmad Al-Suwaehi Syulaibek

    2012-10-01

    Full Text Available This research deals with an important issue, namely: (provisions of transferring organs of executed, it has been divided to: introduction, preface, and three section: The Researcher discuss in the preface: the concept of transfer of human organs, showed the meaning of transportation, the organ, and the meaning of organ transplants. The concept of the executed, its types, showed the meaning of shed, and the executed, and its types. And search in second section: transfer organs of a living person to another, showed the rule of transferring individual organ, and organs of non-individual. An  discussed in the third section: Transfer of organs of the executed to another human being, showed the rule of eating the executed when necessary, and the rule of transferring of organs of the executed, and the rule of reconciliation of the executed on the transfer of its organs in exchange for not killing him, starting the opinions of jurists and their evidence, and discuss the evidence and weighting between opinions. The Researcher concluded that it is permissible to transfer organs of the executed and put it in an human body protected blood near death, under certain conditions to be met, and it is permissible to reconcile the infidel military and spy to waive for not killing him.

  9. Jaapani professor esines Tallinna Tehnikaülikoolis / Mart Min, Enn Velmre

    Index Scriptorium Estoniae

    Min, Mart, 1943-

    2001-01-01

    Külas oli Tohoku Ülikooli prorektor ja biomeditsiinielektroonika labori juhataja Nozomu Hoshimiya, kes pidas loengu halvatud inimeste liigutamisvõime osalisest taastamisest lihaste neuromuskulaarse juhtimise abil elektrilise stimulatsiooni abil

  10. Stationary Random Metrics on Hierarchical Graphs Via {(min,+)}-type Recursive Distributional Equations

    Science.gov (United States)

    Khristoforov, Mikhail; Kleptsyn, Victor; Triestino, Michele

    2016-07-01

    This paper is inspired by the problem of understanding in a mathematical sense the Liouville quantum gravity on surfaces. Here we show how to define a stationary random metric on self-similar spaces which are the limit of nice finite graphs: these are the so-called hierarchical graphs. They possess a well-defined level structure and any level is built using a simple recursion. Stopping the construction at any finite level, we have a discrete random metric space when we set the edges to have random length (using a multiplicative cascade with fixed law {m}). We introduce a tool, the cut-off process, by means of which one finds that renormalizing the sequence of metrics by an exponential factor, they converge in law to a non-trivial metric on the limit space. Such limit law is stationary, in the sense that glueing together a certain number of copies of the random limit space, according to the combinatorics of the brick graph, the obtained random metric has the same law when rescaled by a random factor of law {m} . In other words, the stationary random metric is the solution of a distributional equation. When the measure m has continuous positive density on {mathbf{R}+}, the stationary law is unique up to rescaling and any other distribution tends to a rescaled stationary law under the iterations of the hierarchical transformation. We also investigate topological and geometric properties of the random space when m is log-normal, detecting a phase transition influenced by the branching random walk associated to the multiplicative cascade.

  11. On the Quickest Flow Problem in Dynamic Networks - a Parametric Min-Cost Flow Approach

    OpenAIRE

    Lin, Maokai; Jaillet, Patrick

    2015-01-01

    We consider the quickest flow problem in dynamic networks with a single source s and a single sink t: given an amount of flow F, find the minimum time needed to send it from s to t, and the corresponding optimal flow over time. We introduce new mathematical formulations and derive optimality conditions for the quickest flow problem. Based on the optimality conditions, we develop a new cost-scaling algorithm that leverages the parametric nature of the problem. The algorithm solves the quick...

  12. MODIS/Terra Raw Radiances in Counts 5-Min L1A Swath V005

    Data.gov (United States)

    National Aeronautics and Space Administration — Level 1A collection contains digitized raw detector counts for the 36 MODIS spectral bands as well as engineering and spacecraft ancillary data. Only bands 20 to 36...

  13. MODIS/Terra Geolocation Fields 5-Min L1A Swath 1km V005

    Data.gov (United States)

    National Aeronautics and Space Administration — Geolocation collection contains geodetic latitude and longitude, surface height above geoid, solar zenith and azimuth angles, satellite zenith and azimuth angles,...

  14. 7.5min Quadrangle Index for Acadia National Park (index24.shp)

    Data.gov (United States)

    National Park Service, Department of the Interior — INDEX24 contains 1:24,000 scale neatlines for USGS 7.5 minute quadrangle maps covering Acadia National Park's GIS project area in Maine. The index was originally...

  15. A quantification of the treadmill 6-min walk test using the MyWellness Key™ accelerometer

    Directory of Open Access Journals (Sweden)

    S. Andy Sparks

    2015-06-01

    Conclusion: Estimated energy expenditure provided by the MWK was strongly correlated to 6MWW; however, MWK underestimated energy expenditure as measured by gas analysis. The MWK may provide outcome data that supplement those currently provided by the 6MWD for functional capacity assessment during the t-6MWT.

  16. Min-On Art Group’s Performance Tour Of Beijing and Tianjin

    Institute of Scientific and Technical Information of China (English)

    Yu; Wen

    2014-01-01

    <正>A performance of songs and dances with conspicuous Japanese national features was staged at Beijing Mei Lanfang Grand Theatre last fall.The gorgeous and passionate performance helped the audience experience a great joy as if they had seen the cherry blossom in spring and good harvest in autumn.The music played by a performer rapidly plucking at the Tsugaru Shamisen,a traditional stringed

  17. The MinAdept Clustering Approach for Discovering Reference Process Models out of Process Variants

    NARCIS (Netherlands)

    Li, Chen; Reichert, Manfred; Wombacher, Andreas

    2010-01-01

    During the last years a new generation of adaptive Process-Aware Information Systems (PAIS) has emerged, which enables dynamic process changes at runtime, while preserving PAIS robustness and consistency. Such adaptive PAIS allow authorized users to add new process activities, to delete existing act

  18. Markt van min en meer: recente publicaties op het terrein van de godsdienstpsychologie

    NARCIS (Netherlands)

    J.A. van Belzen

    2012-01-01

    The author presents a number of recent publications in the field of the psychology of religion. The very diverse monographs are categorized as: Introductions, overviews, teaching materials; Psychohistory, especially as applied to the study of the so-called ‘New Testament’; Religious terrorism; Mysti

  19. Increased variability in ApcMin/+ intestinal tissue can be measured with microultrasound

    Science.gov (United States)

    Fatehullah, A.; Sharma, S.; Newton, I. P.; Langlands, A. J.; Lay, H.; Nelson, S. A.; McMahon, R. K.; McIlvenny, N.; Appleton, P. L.; Cochran, S.; Näthke, I. S.

    2016-07-01

    Altered tissue structure is a feature of many disease states and is usually measured by microscopic methods, limiting analysis to small areas. Means to rapidly and quantitatively measure the structure and organisation of large tissue areas would represent a major advance not just for research but also in the clinic. Here, changes in tissue organisation that result from heterozygosity in Apc, a precancerous situation, are comprehensively measured using microultrasound and three-dimensional high-resolution microscopy. Despite its normal appearance in conventionally examined cross-sections, both approaches revealed a significant increase in the variability of tissue organisation in Apc heterozygous tissue. These changes preceded the formation of aberrant crypt foci or adenoma. Measuring these premalignant changes using microultrasound provides a potential means to detect microscopically abnormal regions in large tissue samples, independent of visual examination or biopsies. Not only does this provide a powerful tool for studying tissue structure in experimental settings, the ability to detect and monitor tissue changes by microultrasound could be developed into a powerful adjunct to screening endoscopy in the clinic.

  20. MODIS/TERRA MOD14 Thermal Anomalies & Fire 5-Min L2 Swath 1km

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — MODIS Thermal Anomalies/Fire products are primarily derived from MODIS 4- and 11-micrometer radiances. The fire detection strategy is based on absolute detection of...

  1. Max-Flow Min-Cut Theorems for Multi-User Communication Networks

    OpenAIRE

    Riis, Soren; Gadouleau, Maximilien

    2010-01-01

    The paper presents four distinct new ideas and results for communication networks: 1) We show that relay-networks (i.e. communication networks where different nodes use the same coding functions) can be used to model dynamic networks. 2) We introduce {\\em the term model}, which is a simple, graph-free symbolic approach to communication networks. 3) We state and prove variants of a theorem concerning the dispersion of information in single-receiver communications. 4) We show that the solvabili...

  2. Modern large 3000 rev/min steam turbines for pressurized water reactor power stations

    International Nuclear Information System (INIS)

    The general thermodynamic cycle requirements applying to modern 3000 rpm steam turbines for pressurised water reactor power stations are reviewed. Consideration is given to factors affecting thermal efficiency, including the optimisation of cycle parameters and the use of moisture separation and steam reheating. Principles of mechanical design, based on a modular design concept for turbine cylinders, are discussed with reference to a range of 3000 rpm turbines with outputs up to 1300 MW. The most recent developments, involving machines of 630 MW and 985 MW output currently under construction, are described. The importance of service experience with nuclear steam turbines associated with a variety of types of water cooled reactor is emphasized, and its relevance to the design of modern 3000 rpm turbines for pressurised water reactor applications discussed. (author)

  3. Prdm5 suppresses Apc(Min)-driven intestinal adenomas and regulates monoacylglycerol lipase expression

    DEFF Research Database (Denmark)

    Galli, G G; Multhaupt, H A; Carrara, M;

    2013-01-01

    PRDM proteins are tissue-specific transcription factors often deregulated in diseases, particularly in cancer where different members have been found to act as oncogenes or tumor suppressors. PRDM5 is a poorly characterized member of the PRDM family for which several studies have reported a high ...... PRDM5 target repertoire likely facilitating the tumor-suppressive functions of PRDM5.Oncogene advance online publication, 22 July 2013; doi:10.1038/onc.2013.283....

  4. A min cut-set-wise truncation procedure for importance measures computation in probabilistic safety assessment

    Energy Technology Data Exchange (ETDEWEB)

    Duflot, Nicolas [Universite de technologie de Troyes, Institut Charles Delaunay/LM2S, FRE CNRS 2848, 12, rue Marie Curie, BP2060, F-10010 Troyes cedex (France)], E-mail: nicolas.duflot@areva.com; Berenguer, Christophe [Universite de technologie de Troyes, Institut Charles Delaunay/LM2S, FRE CNRS 2848, 12, rue Marie Curie, BP2060, F-10010 Troyes cedex (France)], E-mail: christophe.berenguer@utt.fr; Dieulle, Laurence [Universite de technologie de Troyes, Institut Charles Delaunay/LM2S, FRE CNRS 2848, 12, rue Marie Curie, BP2060, F-10010 Troyes cedex (France)], E-mail: laurence.dieulle@utt.fr; Vasseur, Dominique [EPSNA Group (Nuclear PSA and Application), EDF Research and Development, 1, avenue du Gal de Gaulle, 92141 Clamart cedex (France)], E-mail: dominique.vasseur@edf.fr

    2009-11-15

    A truncation process aims to determine among the set of minimal cut-sets (MCS) produced by a probabilistic safety assessment (PSA) model which of them are significant. Several truncation processes have been proposed for the evaluation of the probability of core damage ensuring a fixed accuracy level. However, the evaluation of new risk indicators as importance measures requires to re-examine the truncation process in order to ensure that the produced estimates will be accurate enough. In this paper a new truncation process is developed permitting to estimate from a single set of MCS the importance measure of any basic event with the desired accuracy level. The main contribution of this new method is to propose an MCS-wise truncation criterion involving two thresholds: an absolute threshold in addition to a new relative threshold concerning the potential probability of the MCS of interest. The method has been tested on a complete level 1 PSA model of a 900 MWe NPP developed by 'Electricite de France' (EDF) and the results presented in this paper indicate that to reach the same accuracy level the proposed method produces a set of MCS whose size is significantly reduced.

  5. A min-type stochastic fixed-point equation related to the smoothing transformation

    OpenAIRE

    Alsmeyer, Gerold; Meiners, Matthias

    2009-01-01

    This paper is devoted to the study of the stochastic fixed-point equation X \\stackrel{d}{=} \\inf_{i \\geq 1: T_i > 0} X_i/T_i and the connection with its additive counterpart $X \\stackrel{d}{=} \\sum_{i\\ge 1}T_{i}X_{i}$ associated with the smoothing transformation. Here $\\stackrel{d}{=}$ means equality in distribution, $T := (T_i)_{i \\geq 1}$ is a given sequence of nonnegative random variables and $X, X_1, ...$ is a sequence of nonnegative i.i.d. random variables independent of $T$. We draw att...

  6. Increased variability in ApcMin/+ intestinal tissue can be measured with microultrasound

    Science.gov (United States)

    Fatehullah, A.; Sharma, S.; Newton, I. P.; Langlands, A. J.; Lay, H.; Nelson, S. A.; McMahon, R. K.; McIlvenny, N.; Appleton, P. L.; Cochran, S.; Näthke, I. S.

    2016-01-01

    Altered tissue structure is a feature of many disease states and is usually measured by microscopic methods, limiting analysis to small areas. Means to rapidly and quantitatively measure the structure and organisation of large tissue areas would represent a major advance not just for research but also in the clinic. Here, changes in tissue organisation that result from heterozygosity in Apc, a precancerous situation, are comprehensively measured using microultrasound and three-dimensional high-resolution microscopy. Despite its normal appearance in conventionally examined cross-sections, both approaches revealed a significant increase in the variability of tissue organisation in Apc heterozygous tissue. These changes preceded the formation of aberrant crypt foci or adenoma. Measuring these premalignant changes using microultrasound provides a potential means to detect microscopically abnormal regions in large tissue samples, independent of visual examination or biopsies. Not only does this provide a powerful tool for studying tissue structure in experimental settings, the ability to detect and monitor tissue changes by microultrasound could be developed into a powerful adjunct to screening endoscopy in the clinic. PMID:27406832

  7. Muscle Synergies of Untrained Subjects during 6 min Maximal Rowing on Slides and Fixed Ergometer

    OpenAIRE

    Shaharudin, Shazlin; Zanotto, Damiano; Agrawal, Sunil

    2014-01-01

    The slides ergometer (SE) was an improvisation from fixed ergometer (FE) to bridge the gap of mechanics between ergometer rowing and on-water rowing. The specific mechanical constraints of these two types of ergometers may affect the pattern of muscle recruitment, coordination and adaptation. The main purpose of this study was to evaluate the muscle synergy during 6 minutes maximal rowing on slides (SE) and fixed ergometers (FE). The laterality of muscle synergy was also examined. Surface ele...

  8. Lead–Lag Relationship Using a Stop-and-Reverse-MinMax Process

    Directory of Open Access Journals (Sweden)

    Stanislaus Maier-Paape

    2016-07-01

    Full Text Available The intermarket analysis, in particular the lead–lag relationship, plays an important role within financial markets. Therefore, a mathematical approach to be able to find interrelations between the price development of two different financial instruments is developed in this paper. Computing the differences of the relative positions of relevant local extrema of two charts, i.e., the local phase shifts of these price developments, gives us an empirical distribution on the unit circle. With the aid of directional statistics, such angular distributions are studied for many pairs of markets. It is shown that there are several very strongly correlated financial instruments in the field of foreign exchange, commodities and indexes. In some cases, one of the two markets is significantly ahead with respect to the relevant local extrema, i.e., there is a phase shift unequal to zero between them.

  9. Measurement of utero-placental blood flow with /sup 113m/In in diabetic pregnancy

    Energy Technology Data Exchange (ETDEWEB)

    Semmler, K.; Kirsch, G.; Zoellner, P.; Fuhrmann, K.; Jutzi, E. (Zentralinstitut fuer Diabetes, Karlsburg (German Democratic Republic); Ernst-Moritz-Arndt-Universitaet, Greifswald (German Democratic Republic). Radiologische Klinik)

    1985-01-01

    In 122 diabetic pregnancies the placental blood flow has been estimated determining the half-life of the activity inflow (2 MBq /sup 113m/In-transferrin) into the placenta. A highly sensitive detector (modified pinhole collimator) and a computer-supported evaluation were used. 259 flow measurements were compared to the risk of complication in the course of diabetic pregnancy. The half-life values in the diabetic group, calculated by a gamma camera computer system by means of an iterative regression analysis, were significantly different compared to a control group (12 pregnancies without risk.) Severe diabetic angiopathic complications (classes D, F, and R according to White) are accompanied by higher half-life values (placental blood flow reductions) and perinatal complications. Even in pregnant women with gestational diabetes of disturbances of the carbohydrate metabolism disturbed placental hemodynamics is to be found.

  10. Hvorfra min verden går:et Luhmann-inspireret bidrag til didaktikken

    OpenAIRE

    Keiding, Tina Bering

    2005-01-01

    Afhandlingens problemformulering består af to spørgsmål. For det første hvordan cen-trale begreber for uddannelse og undervisning falder ud inden for rammerne af Niklas Luhmanns systemteori. For det andet hvordan disse begrebsafklaringer kan bidrage til udvikling af den teoretiske didaktik, herunder tematisering af spørgs-målet om, hvad der synes at udgøre centrale elementer i kommunikation, der har intentioner om at indvirke på og forandre andre systemer, samt spørgsmålet om, og i givet fald...

  11. Evolution of the Petrophysical and Mineralogical Properties of Two Reservoir Rocks Under Thermodynamic Conditions Relevant for CO2 Geological Storage at 3 km Depth Évolution des propriétés physiques et minéralogiques de deux roches réservoirs dans des conditions thermodynamiques correspondant à un stockage géologique de CO2 à 3 km de profondeur

    Directory of Open Access Journals (Sweden)

    Rimmelé G.

    2009-11-01

    est considérée comme une solution pour contribuer à la réduction des émissions de gaz à effet de serre dans l’atmosphère. Les interactions entre le CO2 supercritique et la roche-réservoir potentielle doivent être étudiées en détail en conditions de stockage géologique. Quarante échantillons de calcaire de Lavoux et de grès d’Adamswiller, provenant de roches réservoirs du bassin parisien, ont été expérimentalement exposés au CO2 dans un autoclave spécialement construit pour reproduire les conditions thermodynamiques d’un réservoir de stockage de CO2. Les deux types de roches ont été exposés pendant un mois à du CO2 supercritique humide et à de l’eau saturée en CO2, à 28 MPa et 90 °C, ce qui correspond à des conditions d’enfouissement de 3 km de profondeur. L’évolution de leurs propriétés minéralogiques a été suivie par des analyses par diffraction des rayons X, par spectroscopie Raman et par microscopie électronique couplée à un système de microanalyses X. Leurs propriétés physiques et microtexturales ont été estimées en mesurant, avant et après les expériences, le poids, la densité, les propriétés mécaniques, la perméabilité, la porosité globale et la présence d’éventuels gradients de porosité de chaque échantillon. Les résultats montrent que les deux roches ont préservé leurs propriétés mécaniques et minéralogiques, malgré une augmentation de la porosité et de la perméabilité. Des zones microscopiques de dissolution de la calcite observées dans le calcaire sont vraisemblablement responsables de cette augmentation de la perméabilité et de la porosité. Dans le grès, une altération de la pétro-fabrique est supposée se produire due à la réaction des minéraux argileux avec le CO2. Tous les échantillons du calcaire de Lavoux et du grès d’Adamswiller ont montré une altération mesurable dans le CO2 humide et dans l’eau chargée en CO2. Ces expériences en autoclave sont

  12. Re-evaluation of microscopic and integral cross-section data for important dosimetry reactions. Re-evaluation of the excitation functions for the 24Mg(n,p)24Na, 32S(n,p)32P, 60Ni(n,p)60m+gCo, 63Cu(n,2n)62Cu, 65Cu(n,2n)64Cu, 64Zn(n,p)64Cu, 115In(n,2n)114mIn, 127I(n,2n)126I, 197Au(n,2n)196Au and 199Hg(n,n')199mHg reactions

    International Nuclear Information System (INIS)

    Re-evaluations of cross sections and their associated covariance matrices have been carried out for ten dosimetry reactions: - excitation functions for the 63Cu(n,2n)62Cu, 65Cu(n,2n)64Cu, 64Zn(n,p)64Cu, 115In(n,2n)114mIn and 199Hg(n,n')199mHg reactions were re-evaluated over the neutron energy range from threshold to 20 MeV; - excitation functions for the 24Mg(n,p)24Na, 32S(n,p)32P and 60Ni(n,p)60m+gCo were reevaluated in the energy range from threshold to 21 MeV; - excitation functions for the 127I(n,2n)126I and 197Au(n,2n)196Au reactions were reevaluated in the energy range from threshold to 32 and 40 MeV, respectively. Benchmark calculations performed for 235U thermal fission and 252Cf spontaneous fission neutron spectra show that the integral cross sections derived from the newly evaluated excitation functions exhibit improved agreement with related experimental data when compared with the equivalent data from the IRDF-2002 library. (author)

  13. Human albümin replasmanının karaciğer alıcılarında serum albümin düzeyine etkisi

    OpenAIRE

    M, Uyar; C, Bor; L, Acar; K, Demirağ

    2013-01-01

    Amaç: Karaciğer transplant hastalarında düşük serum albumin düzeylerinin kötü prognoz belirtisi olduğu ve bu hastalarda erken postoperatif dönemde ciddi hipoalbüminemi gelişebileceği bildirilmiştir. Yoğun bakımımızda serum albumin düzeyi 3.0 g.dL-1 altında belirlenen karaciğer alıcılarına rutin olarak human albumin replasmanı uygulamaktadır. Çalışmamızın amacı karaciğer transplantasyonu uygulanan hastalarda postoperatif devrede uygulanan albumin replasmanı stratejisinin retrospektif olarak de...

  14. Visit of Dr Stahl, Secretary of State, Federal Ministry for Education Science, Research and Technology, Germany, accompanied by MinDirig Dr Eschelbacher and MinR Dr Freytag

    CERN Multimedia

    Laurent Guiraud

    1998-01-01

    Visiting CERN on 19 January was Helmut Stahl, Secretary of State of the German Federal Ministry of Science, Education, Research and Technology (centre) seen here admiring prototype magnets for CERN's LHC proton collider with new President of CERN Council Hans Eschelbacher (right) and German delegate to CERN Council Arno Freytag. In the background is Dietrich Gusewell, Head of CERN's EST (Engineering Support and Technologies) Division.

  15. 浅论李大钊的"民彝"思想%Easily Discussion of Li Dazhao's "Min Yi" Thinking

    Institute of Scientific and Technical Information of China (English)

    祖雷; 张卫军

    2006-01-01

    在李大钊早期的民主主义思想中,其核心是"民彝"思想."民彝"是李大钊从中国传统文化中找到的同"民众之意志"相对应的概念,在李大钊看来,"民彝者,吾民衡量事理之器";"民彝者,民宪之基础也"、"信其民彝,彰其民彝".

  16. Variability of the MAX and MIN Statistic: A Theory of the Quantile Spread as a Function of Sample Size

    Science.gov (United States)

    Townsend, James T.; Colonius, Hans

    2005-01-01

    The maximum and minimum of a sample from a probability distribution are extremely important random variables in many areas of psychological theory, methodology, and statistics. For instance, the behavior of the mean of the maximum or minimum processing time, as a function of the number of component random processing times ("n"), has been studied…

  17. Classification and Segregation of Abnormal Lymphocytes through Image Mining for Diagnosing Rheumatoid Arthritis Using Min-max Algorithm

    Directory of Open Access Journals (Sweden)

    S.P. Chokkalingam

    2014-05-01

    Full Text Available Advances in the acquisition of complex medical images and storing it for further analysis through image mining have significantly helped to identify the root causes for various diseases. Mining of medical image data set such as scanned images or blood cell images require extraction of implicit knowledge from the data set through hierarchical image processing techniques and identifying the relationships and patterns that are not explicitly stored in a single image. Rheumatoid Arthritis (RA is an autoimmune disease and it cause chronic inflammation of the joints. Causes of the RA is unknown due to that need to find out in the early stage is required. Diagnosis of RA based on blood cell types and shapes requires computational analysis. An assistive technology for the doctor to detect and investigate rheumatoid arthritis is therefore required. The objective of the proposed work is to analyze the shapes of lymphocytes, a key component of blood cells that causes RA complications, to automate the process of identifying abnormal lymphocytes by estimating the centroids of lymphocytes using AIT centroid technique and thereby finding a differential count. The process involves cropping nucleus from the blood cell image, segmenting it and to investigate further whether the shapes of the lymphocytes are irregular and dissimilar. Features are extracted from each cell components for comparison and the abnormal lymphocytes are segregated from the normal. To enhance the segregation process, neural network based perceptron classifier tool is used.

  18. Spectrum Sharing in Cognitive Radio Prop up the Minimum Transmission Power and Maxi-Min SINR Stratagem

    Directory of Open Access Journals (Sweden)

    S. Azmat. Hussain

    2013-12-01

    Full Text Available With the rapid growth of vigilance that cognitive radio participate an essential task in wireless communication to resolve the spectrum scarcity vs. under-utilization dilemma owing to the dormant spectrum supervision policies. In this study, we explore the innovative scenario that the secondary user frequently has to trade off between two goals at the same time: one is to maximize its own throughput; and the other is to minimize interference at primary receiver. In conclusion, the author give a novel idea about the seminal work of spectrum sharing by minimizing transmit power strategy and maximizing Signal to Interference plus Noise Ratio (SINR strategy which are inversely and directly proportional according to the condition of separation angles.

  19. US 943 - A 19th mag eclipsing cataclysmic variable with a period of 2 hr 3.8 min

    Science.gov (United States)

    Howell, S. B.; Warnock, A.; Mason, K. O.; Reichert, G. A.; Kreidl, T. J.

    1988-01-01

    The high-latitude, V equals about 19.5, blue variable star US 943 is found to be an eclipsing binary with an orbital period of 2.06 hr. The light curve is dominated by an orbital hump which has an amplitude of 0.9 mag in V and is centered about 0.17 orbital cycles before the 1.5-mag deep eclipse. There is evidence that the eclipse has at least two components. The overall appearance of the star is that of a dwarf nova in quiescence, a conclusion that is supported by the observation of a subsequent bright state (V equals about 15) suggesting a dwarf nova outburst.

  20. nowCOAST's Map Service for NOAA NWS NDFD Forecasts of Daily Min Surface Air Temperature (deg. F) (Time Offsets)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Map Information: This nowCOAST time-offsets map service provides maps depicting the NWS daily minimum surface air temperature forecasts from the National Digital...