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Sample records for 10d effective action

  1. Thermopower, Hall effect and magnetoresistivity of Ru 1- xSb xSr 2Sm 1.5Ce 0.5Cu 2O 10- d

    Science.gov (United States)

    Ilonca, G.; Patapis, S.; Beiusan, F.; Lung, C.; Toma, V.; Balint, P.; Bodea, M.; Jurcut, T.

    2007-09-01

    Magnetoresistivity, thermopower and Hall effect on the samples of Ru1-xSbxSr2Sm1.5Ce0.5Cu2O10-d were investigated in the temperature range 4-300 K with a magnetic field up to 9 T. Superconducting transition temperature decreases with increases content of Sb, due to a distortion of RuO6 octahedral, which is responsible of the increase in hole localization, reflected by Hall concentration, too. The inhomogeneous granular structure is put in evidence by the intragranular, Tco, and intergranular Tcg, transition temperatures. Hall effect and thermopower anomalous decreases below Tmagnetic can be explained within a simple two-band model by a transition from localized to more itinerant behavior in the RuO2 layer at Tmagnetic.

  2. Effects of Security actions

    Science.gov (United States)

    Bergman, Ramona; Andersson-Sköld, Yvonne; Nyberg, Lars; Johansson, Magnus

    2010-05-01

    In a project funded by the Swedish Civil Contingencies Agency, the effort and work to reduce different kinds of accidents are being evaluated. The project wants to illuminate the links between actions and outcome, so we can learn from today's performance and in the future select more effective measures and overall deal with accidents more efficiently. The project ESS covers the field of frequent accidents such as sliding accidents at home, in house fires and less common accidents such as chemical and land fill accidents up to even more rare accidents such as natural accidents and hazards. In the ESS project SGI (Swedish geotechnical institute) will evaluate the work and effort concerning various natural hazards limited to landslides, erosion and flooding. The aim is to investigate how municipalities handle, especially prevention, of such natural disasters today. The project includes several aspects such as: • which are the driving forces for risk analysis in a municipality • do one use risk mapping (and what type) in municipal risk analysis • which aspects are most important when selecting preventive measures • in which way do one learn from past accidents • and from previous accidents elsewhere, by for example use existing databases • etc There are many aspects that play a role in a well-functioning safety promotion work. The overall goal is to examine present work and activities, highlight what is well functioning and identify weak points. The aim is to find out where more resources are needed and give suggestions for a more efficient security work. This includes identification of the most efficient "tools" in use or needed. Such tools can be education, directives, funding, more easily available maps and information regarding previous accidents and preventive measures etc. The project will result in recommendations for more effective ways to deal with landslides, erosion and flooding. Since different kinds of problems can occur depending on level of

  3. Separate and combined effects of a 10-d exposure to hypoxia and inactivity on oxidative function in vivo and mitochondrial respiration ex vivo in humans.

    Science.gov (United States)

    Salvadego, Desy; Keramidas, Michail E; Brocca, Lorenza; Domenis, Rossana; Mavelli, Irene; Rittweger, Jörn; Eiken, Ola; Mekjavic, Igor B; Grassi, Bruno

    2016-07-01

    An integrative evaluation of oxidative metabolism was carried out in 9 healthy young men (age, 24.1 ± 1.7 yr mean ± SD) before (CTRL) and after a 10-day horizontal bed rest carried out in normoxia (N-BR) or hypoxia (H-BR, FiO2 = 0.147). H-BR was designed to simulate planetary habitats. Pulmonary O2 uptake (V̇o2) and vastus lateralis fractional O2 extraction (changes in deoxygenated hemoglobin+myoglobin concentration, Δ[deoxy(Hb+Mb)] evaluated using near-infrared spectroscopy) were evaluated in normoxia and during an incremental cycle ergometer (CE) and one-leg knee extension (KE) exercise (aimed at reducing cardiovascular constraints to oxidative function). Mitochondrial respiration was evaluated ex vivo by high-resolution respirometry in permeabilized vastus lateralis fibers. During CE V̇o2peak and Δ[deoxy(Hb+Mb)]peak were lower (P work rate exercise was greater in N-BR and H-BR than CTRL, whereas during KE a significant difference vs. CTRL was observed only after N-BR. Maximal mitochondrial respiration determined ex vivo was not affected by either intervention. In N-BR, a significant impairment of oxidative metabolism occurred downstream of central cardiovascular O2 delivery and upstream of mitochondrial function, possibly at the level of the intramuscular matching between O2 supply and utilization and peripheral O2 diffusion. Superposition of hypoxia on bed rest did not aggravate, and partially reversed, the impairment of muscle oxidative function in vivo induced by bed rest. The effects of longer exposures will have to be determined. PMID:27197861

  4. Wilsonian Effective Action of Superstring Theory

    CERN Document Server

    Sen, Ashoke

    2016-01-01

    By integrating out the heavy fields in type II or heterotic string field theory one can construct the effective action for the light fields. This effective theory inherits all the algebraic structures of the parent theory and the effective action automatically satisfies the Batalin-Vilkovisky quantum master equation. This theory is manifestly ultraviolet finite, has only light fields as its explicit degrees of freedom, and the Feynman diagrams of this theory reproduce the exact scattering amplitudes of light states in string theory to any arbitrary order in perturbation theory. Furthermore in this theory the degrees of freedom of light fields above certain energy scale are also implicitly integrated out. This energy scale is determined by a particular parameter labelling a family of equivalent actions, and can be made arbitrarily low, leading to the interpretation of the effective action as the Wilsonian effective action.

  5. On String Field Theory and Effective Actions

    OpenAIRE

    Giveon, Amit

    1992-01-01

    A truncation of string field theory is compared with the duality invariant effective action of $D=4, N=4$ heterotic strings to cubic order. The three string vertex must satisfy a set of compatibility conditions. Any cyclic three string vertex is compatible with the $D=4, N=4$ effective field theory. The effective actions may be useful in understanding the non--polynomial structure and the underlying symmetry of covariant closed string field theory, and in addressing issues of background indep...

  6. Effective supergravity actions for conifold transitions

    Energy Technology Data Exchange (ETDEWEB)

    Mohaupt, Thomas; Saueressig, Frank E-mail: F.S.Saueressig@phys.uu.nl

    2005-03-01

    We construct gauged supergravity actions which describe the dynamics of M-theory on a Calabi-Yau threefold in the vicinity of a conifold transition. The actions explicitly include N charged hypermultiplets descending from wrapped M2-branes which become massless at the conifold point. While the vector multiplet sector can be treated exactly, we approximate the hypermultiplet sector by the non-compact Wolf spaces X(1+N). The effective action is then uniquely determined by the charges of the wrapped M2-branes. (author)

  7. Action-based effects on music perception.

    Science.gov (United States)

    Maes, Pieter-Jan; Leman, Marc; Palmer, Caroline; Wanderley, Marcelo M

    2014-01-01

    The classical, disembodied approach to music cognition conceptualizes action and perception as separate, peripheral processes. In contrast, embodied accounts of music cognition emphasize the central role of the close coupling of action and perception. It is a commonly established fact that perception spurs action tendencies. We present a theoretical framework that captures the ways in which the human motor system and its actions can reciprocally influence the perception of music. The cornerstone of this framework is the common coding theory, postulating a representational overlap in the brain between the planning, the execution, and the perception of movement. The integration of action and perception in so-called internal models is explained as a result of associative learning processes. Characteristic of internal models is that they allow intended or perceived sensory states to be transferred into corresponding motor commands (inverse modeling), and vice versa, to predict the sensory outcomes of planned actions (forward modeling). Embodied accounts typically refer to inverse modeling to explain action effects on music perception (Leman, 2007). We extend this account by pinpointing forward modeling as an alternative mechanism by which action can modulate perception. We provide an extensive overview of recent empirical evidence in support of this idea. Additionally, we demonstrate that motor dysfunctions can cause perceptual disabilities, supporting the main idea of the paper that the human motor system plays a functional role in auditory perception. The finding that music perception is shaped by the human motor system and its actions suggests that the musical mind is highly embodied. However, we advocate for a more radical approach to embodied (music) cognition in the sense that it needs to be considered as a dynamical process, in which aspects of action, perception, introspection, and social interaction are of crucial importance. PMID:24454299

  8. Action-based effects on music perception.

    Science.gov (United States)

    Maes, Pieter-Jan; Leman, Marc; Palmer, Caroline; Wanderley, Marcelo M

    2014-01-01

    The classical, disembodied approach to music cognition conceptualizes action and perception as separate, peripheral processes. In contrast, embodied accounts of music cognition emphasize the central role of the close coupling of action and perception. It is a commonly established fact that perception spurs action tendencies. We present a theoretical framework that captures the ways in which the human motor system and its actions can reciprocally influence the perception of music. The cornerstone of this framework is the common coding theory, postulating a representational overlap in the brain between the planning, the execution, and the perception of movement. The integration of action and perception in so-called internal models is explained as a result of associative learning processes. Characteristic of internal models is that they allow intended or perceived sensory states to be transferred into corresponding motor commands (inverse modeling), and vice versa, to predict the sensory outcomes of planned actions (forward modeling). Embodied accounts typically refer to inverse modeling to explain action effects on music perception (Leman, 2007). We extend this account by pinpointing forward modeling as an alternative mechanism by which action can modulate perception. We provide an extensive overview of recent empirical evidence in support of this idea. Additionally, we demonstrate that motor dysfunctions can cause perceptual disabilities, supporting the main idea of the paper that the human motor system plays a functional role in auditory perception. The finding that music perception is shaped by the human motor system and its actions suggests that the musical mind is highly embodied. However, we advocate for a more radical approach to embodied (music) cognition in the sense that it needs to be considered as a dynamical process, in which aspects of action, perception, introspection, and social interaction are of crucial importance.

  9. Action-based effects on music perception

    Directory of Open Access Journals (Sweden)

    Pieter-Jan eMaes

    2014-01-01

    Full Text Available The classical, disembodied approach to music cognition conceptualizes action and perception as separate, peripheral phenomena. In contrast, embodied accounts to music cognition emphasize the central role of the close coupling of action and perception. It is a commonly established fact that perception spurs action tendencies. We present a theoretical framework capturing the ways that the human motor system, and the actions it produces, can reciprocally influence the perception of music. The cornerstone of this framework is the common coding theory postulating a representational overlap in the brain between the planning, the execution, and the perception of movement. The integration of action and perception in so-called internal models is explained as a result of associative learning processes. Characteristic of internal models is that they allow intended or perceived sensory states to be transferred into corresponding motor commands (inverse modelling, and vice versa, to predict the sensory outcomes of planned actions (forward modelling. Embodied accounts typically adhere to inverse modelling to explain action effects on music perception (Leman, 2007. We extent this account by pinpointing forward modelling as an alternative mechanism by which action can modulate perception. We provide an extensive overview of recent empirical evidence in support of this idea. Additionally, we demonstrate that motor dysfunctions can cause perceptual disabilities, supporting the main idea of the paper that the human motor system plays a functional role in auditory perception. The finding that music perception is shaped by the human motor system, and the action it produces, suggests that the musical mind is highly embodied. However, we advocate for a more radical approach to embodied (music cognition in the sense that it needs to be considered as a dynamic process, in which aspects of action, perception, introspection, and social interaction are of crucial

  10. (-)-Carvone: antispasmodic effect and mode of action.

    Science.gov (United States)

    Souza, Fábia Valéria M; da Rocha, Marcelly Barbosa; de Souza, Damião P; Marçal, Rosilene Moretti

    2013-03-01

    (-)-Carvone is a monoterpene ketone found in spearmint (Mentha spicata var. crispa) essential oil that is widely used as an odor and flavor additive. An intestinal antispasmodic effect was recently reported for (-)-carvone, and it has been shown to be more potent than its (+)-antipode. The mechanism of (-)-carvone action in the intestines has not been investigated. To gain a better understanding of the (-)-carvone antispasmodic effect, we investigated its pharmacological effects in the guinea pig ileum. Terminal portions of the ileum were mounted for isotonic contraction recordings. The effect of (-)-carvone was compared with that of the classical calcium channel blocker (CCB) verapamil. In isolated ileal smooth muscle, (-)-carvone did not produce direct contractile or relaxation responses and did not modify electrically elicited contractions or low K(+)-evoked contractions. The submaximal contractions induced by histamine (p<0.001), BaCl2 (p<0.05), and carbachol (p<0.01) were significantly reduced by (-)-carvone. The contractile response elicited by high concentrations of carbachol was reduced but not abolished by (-)-carvone. No additive action was detected with co-incubation of (-)-carvone and verapamil on carbachol-induced contraction. (-)-Carvone reduced the contraction induced by high K(+) and was almost 100 times more potent than verapamil. Thus, (-)-carvone showed a typical and potent CCB-like action. Many effects described for both (-)-carvone and spearmint oil can be explained as a CCB-like mode of action. PMID:23103297

  11. (-)-Carvone: antispasmodic effect and mode of action.

    Science.gov (United States)

    Souza, Fábia Valéria M; da Rocha, Marcelly Barbosa; de Souza, Damião P; Marçal, Rosilene Moretti

    2013-03-01

    (-)-Carvone is a monoterpene ketone found in spearmint (Mentha spicata var. crispa) essential oil that is widely used as an odor and flavor additive. An intestinal antispasmodic effect was recently reported for (-)-carvone, and it has been shown to be more potent than its (+)-antipode. The mechanism of (-)-carvone action in the intestines has not been investigated. To gain a better understanding of the (-)-carvone antispasmodic effect, we investigated its pharmacological effects in the guinea pig ileum. Terminal portions of the ileum were mounted for isotonic contraction recordings. The effect of (-)-carvone was compared with that of the classical calcium channel blocker (CCB) verapamil. In isolated ileal smooth muscle, (-)-carvone did not produce direct contractile or relaxation responses and did not modify electrically elicited contractions or low K(+)-evoked contractions. The submaximal contractions induced by histamine (p<0.001), BaCl2 (p<0.05), and carbachol (p<0.01) were significantly reduced by (-)-carvone. The contractile response elicited by high concentrations of carbachol was reduced but not abolished by (-)-carvone. No additive action was detected with co-incubation of (-)-carvone and verapamil on carbachol-induced contraction. (-)-Carvone reduced the contraction induced by high K(+) and was almost 100 times more potent than verapamil. Thus, (-)-carvone showed a typical and potent CCB-like action. Many effects described for both (-)-carvone and spearmint oil can be explained as a CCB-like mode of action.

  12. Effective boundary action in fermion string theory

    International Nuclear Information System (INIS)

    Continual Polyakov integral for the Neveu-Schwarz-Ramon (NSR) type fermion string is calculated on the Riemann Surface with special choice of local boundary conditions for the fermion fields. The derived expressions are used when studying behaviour of the string Green function in configurational space. Generalization of the effective fermion action for the case of non-Archimedean strings is discussed. 11 refs

  13. Holographic effective actions from black holes

    International Nuclear Information System (INIS)

    Using the Wald's relation between the Noether charge of diffeomorphisms and the entropy for a generic spacetime possessing a bifurcation surface, we introduce a method to obtain a family of higher order derivatives effective actions from the entropy of black holes. We consider the entropy as the starting point and we analyze the procedure of derivation of the action functional. We specialize to a particular class of theories which simplifies the calculations, f(R) theories. We apply the procedure to loop quantum gravity and to a general class of log-corrected entropy formulas.

  14. Symmetry-improved CJT effective action

    International Nuclear Information System (INIS)

    The formalism introduced by Cornwall, Jackiw and Tomboulis (CJT) provides a systematic approach to consistently resumming non-perturbative effects in Quantum Thermal Field Theory. One major limitation of the CJT effective action is that its loopwise expansion introduces residual violations of possible global symmetries, thus giving rise to massive Goldstone bosons in the spontaneously broken phase of the theory. In this paper we develop a novel symmetry-improved CJT formalism for consistently encoding global symmetries in a loopwise expansion. In our formalism, the extremal solutions of the fields and propagators to a loopwise truncated CJT effective action are subject to additional constraints given by the Ward Identities due to global symmetries. By considering a simple O(2) scalar model, we show that, unlike other methods, our approach satisfies a number of important field-theoretic properties. In particular, we find that the Goldstone boson resulting from spontaneous symmetry breaking of O(2) is massless and the phase transition is a second-order one, already in the Hartree–Fock approximation. After taking the sunset diagrams into account, we show how our approach properly describes the threshold properties of the massless Goldstone boson and the Higgs particle in the loops. Finally, assuming minimal modifications to the Hartree–Fock approximated CJT effective action, we calculate the corresponding symmetry-improved CJT effective potential and discuss the conditions for its uniqueness for scalar-field values away from its minimum

  15. Cosmic fluctuations from quantum effective action

    CERN Document Server

    Wetterich, C

    2015-01-01

    Does the observable spectrum of cosmic fluctuations depend on detailed initial conditions? This addresses the question if the general inflationary paradigm is sufficient to predict within a given model the spectrum and amplitude of cosmic fluctuations, or if additional particular assumptions about the initial conditions are needed. The answer depends on the number of e-foldings $N_{in}$ between the beginning of inflation and horizon crossing of the observable fluctuations. We discuss an interacting inflaton field in an arbitrary homogeneous and isotropic geometry, employing the quantum effective action $\\Gamma$. An exact time evolution equation for the correlation function involves the second functional derivative $\\Gamma^{(2)}$. The operator formalism and quantum vacua for interacting fields are not needed. Use of the effective action also allows one to address the change of frames by field transformations (field relativity). For not too large $N_{in}$ we find that memory of the initial conditions is preserv...

  16. Effectively Discriminating Fighting Shots in Action Movies

    Institute of Scientific and Technical Information of China (English)

    Shu-Gao Ma; Wei-Qiang Wang

    2011-01-01

    Fighting shots are the highlights of action movies and an effective approach to discriminating fighting shots is very useful for many applications, such as movie trailer construction, movie content filtering, and movie content retrieval. In this paper, we present a novel method for this task. Our approach first extracts the reliable motion information of local invariant features through a robust keypoint tracking computation; then foreground keypoints are distinguished from background keypoints by a sophisticated voting process; further, the parameters of the camera motion model is computed based on the motion information of background keypoints, and this model is then used as a reference to compute the actual motion of foreground keypoints; finally, the corresponding feature vectors are extracted to characterizing the motions of foreground keypoints, and a support vector machine (SVM) classifier is trained based on the extracted feature vectors to discriminate fighting shots. Experimental results on representative action movies show our approach is very effective.

  17. Effective action in general chiral superfield model

    OpenAIRE

    Petrov, A. Yu.

    2000-01-01

    The effective action in general chiral superfield model with arbitrary k\\"{a}hlerian potential $K(\\bar{\\Phi},\\Phi)$ and chiral (holomorphic) potential $W(\\Phi)$ is considered. The one-loop and two-loop contributions to k\\"{a}hlerian effective potential and two-loop (first non-zero) contribution to chiral effective potential are found for arbitrary form of functions $K(\\bar{\\Phi},\\Phi)$ and $W(\\Phi)$. It is found that despite the theory is non-renormalizable in general case two-loop contributi...

  18. Instant Attraction: Immediate Action-Effect Bindings Occur for Both, Stimulus- and Goal-Driven Actions

    OpenAIRE

    Janczyk, Markus; Heinemann, Alexander; Pfister, Roland

    2012-01-01

    Flexible behavior is only possible if contingencies between own actions and following environmental effects are acquired as quickly as possible; and recent findings indeed point toward an immediate formation of action-effect bindings already after a single coupling of an action and its effect. The present study explored whether these short-term bindings occur for both, stimulus- and goal-driven actions (“forced-choice actions” vs. “free-choice actions”). Two experiments confirmed that immedia...

  19. Effective action approach to quantum chromodynamics

    International Nuclear Information System (INIS)

    Though the Lagrangian of quantum chromodynamics is well known, it has proven extremely difficult to derive precisely all its consequences to compare with experiment. Approximations based on physical reasoning must be made. One method is to calculate the effective action for some particularly simple configuration of gluons and use this to analyze an arbitrary system of interacting quarks. In the first chapter, the one-loop correction to the gluon propagator is computed in two different ways - dimensional regularization and Schwinger's proper time method. The renormalization mass parameters appearing in the two treatments can then be related and the exact one-loop effective action of a constant gluon field can be expressed in terms of the experimentally determinable Λ/sub MS/. In the following chapter, the interaction of a heavy quark-antiquark pair governed by this action is considered and it is shown how the spectrum, and, in particular, the spin splittings of the bound states can be found. Due to asymptotic freedom, a massive quarkonium is analogous to a non-relativistic electromagnetic system. At short distances, the results are the same as those derived from perturbation theory though, for example, the hyperfine structure arises in a different way. At large distances, the analysis is qualitative but our results agree with the predictions of strong coupling lattice gauge theories

  20. Effective actions for relativistic fluids from holography

    CERN Document Server

    de Boer, Jan; Pinzani-Fokeeva, Natalia

    2015-01-01

    Motivated by recent progress in developing action formulations of relativistic hydrodynamics, we use holography to derive the low energy dissipationless effective action for strongly coupled conformal fluids. Our analysis is based on the study of novel double Dirichlet problems for the gravitational field, in which the boundary conditions are set on two codimension one timelike hypersurfaces (branes). We provide a geometric interpretation of the Goldstone bosons appearing in such constructions in terms of a family of spatial geodesics extending between the ultraviolet and the infrared brane. Furthermore, we discuss supplementing double Dirichlet problems with information about the near-horizon geometry. We show that upon coupling to a membrane paradigm boundary condition, our approach reproduces correctly the complex dispersion relation for both sound and shear waves. We also demonstrate that upon a Wick rotation, our formulation reproduces the equilibrium partition function formalism, provided the near-horiz...

  1. On Effective Actions for the Bosonic Tachyon

    CERN Document Server

    Smedbäck, M

    2003-01-01

    We extend the analysis of hep-th/0304045 to the bosonic case and find the one-derivative effective action valid in the vicinity of rolling tachyons with an energy not larger than that of the original D-brane. For on-shell tachyons rolling down the well-behaved side of the potential in this theory, the energy is conserved and the pressure eventually decreases exponentially. For tachyons rolling down the ''wrong'' side, the pressure instead blows up in a finite time.

  2. Effective actions for statistical data assimilation

    International Nuclear Information System (INIS)

    Data assimilation is a problem in estimating the fixed parameters and state of a model of an observed dynamical system as it receives inputs from measurements passing information to the model. Using methods developed in statistical physics, we present effective actions and equations of motion for the mean orbits associated with the temporal development of a dynamical model when it has errors, there is uncertainty in its initial state, and it receives information from noisy measurements. If there are statistical dependences among errors in the measurements they can be included in this approach.

  3. Effective action calculation in lattice QCD

    International Nuclear Information System (INIS)

    A method (called the effective action method) devised to make analytic calculations in Quantum Chromodynamics in the region of strong coupling is presented. First, the author deals with developing the calculation of a strong coupling expansion of the generating functional for gauge systems on a lattice with arbitrary sources. An accompanying manual describes the implementation of this calculation on a computer. The next step consists of substituting the expressions for the one-link free energies for a specific gauge group in the result of the previous calculation. This process of substitution, together with the replacement of the sources by a bilinear combination of fermion fields, is described for the group SU(3). More details on the implementation of the substitution scheme on a computer can be found in the accompanying manual. From the effective action thus obtained in terms of meson fields and baryon fields the Green functions of the theory can be derived. As an illustrative application the effective potential determining the vacuum expectation value of the meson field is calculated. (Auth.)

  4. Exploring soft constraints on effective actions

    CERN Document Server

    Bianchi, Massimo; Huang, Yu-tin; Lee, Chao-Jung; Wen, Congkao

    2016-01-01

    We study effective actions for simultaneous breaking of space-time and internal symmetries. Novel features arise due to the mixing of Goldstone modes under the broken symmetries which, in contrast to the usual Adler's zero, leads to non-vanishing soft limits. Such scenarios are common for spontaneously broken SCFT's. We explicitly test these soft theorems for $\\mathcal{N}=4$ sYM in the Coulomb branch both perturbatively and non-perturbatively. We explore the soft constraints systematically utilizing recursion relations. In the pure dilaton sector of a general CFT, we show that all amplitudes up to order $s^{n} \\sim \\partial^{2n}$ are completely determined in terms of the $k$-point amplitudes at order $s^k$ with $k \\leq n$. Terms with at most one derivative acting on each dilaton insertion are completely fixed and coincide with those appearing in the conformal DBI, i.e. DBI in AdS. With maximal supersymmetry, the effective actions are further constrained, leading to new non-renormalization theorems. In particu...

  5. The Universal One-Loop Effective Action

    CERN Document Server

    Drozd, Aleksandra; Quevillon, Jérémie; You, Tevong

    2016-01-01

    We present the universal one-loop effective action for all operators of dimension up to six obtained by integrating out massive, non-degenerate multiplets. Our general expression may be applied to loops of heavy fermions or bosons, and has been checked against partial results available in the literature. The broad applicability of this approach simplifies one-loop matching from an ultraviolet model to a lower-energy effective field theory (EFT), a procedure which is now reduced to the evaluation of a combination of matrices in our universal expression, without any loop integrals to evaluate. We illustrate the relationship of our results to the Standard Model (SM) EFT, using as an example the supersymmetric stop and sbottom squark Lagrangian and extracting from our universal expression the Wilson coefficients of dimension-six operators composed of SM fields.

  6. The universal one-loop effective action

    Science.gov (United States)

    Drozd, Aleksandra; Ellis, John; Quevillon, Jérémie; You, Tevong

    2016-03-01

    We present the universal one-loop effective action for all operators of dimension up to six obtained by integrating out massive, non-degenerate multiplets. Our general expression may be applied to loops of heavy fermions or bosons, and has been checked against partial results available in the literature. The broad applicability of this approach simplifies one-loop matching from an ultraviolet model to a lower-energy effective field theory (EFT), a procedure which is now reduced to the evaluation of a combination of matrices in our universal expression, without any loop integrals to evaluate. We illustrate the relationship of our results to the Standard Model (SM) EFT, using as an example the supersymmetric stop and sbottom squark Lagrangian and extracting from our universal expression the Wilson coefficients of dimension-six operators composed of SM fields.

  7. The effective action for composite Higgs particles

    International Nuclear Information System (INIS)

    There is reason to believe that massive composite (fermion-antifermion) scalar particles closely resembling the usual fundamental scalar Higgs fields exist in theories with dynamically broken gauge symmetries. This composite Higgs couples directly to the fermions in proportion to their symmetry-violating self-energies. Induced couplings to the gauge bosons and self-couplings are claculated as loop effects. This involves deriving the effective action in terms of the full propagators and background fields. The couplings between the composite Higgs and the gauge bosons are the same as those in models with fundamental scalars. The self-couplings are determined and fix all parameters associated with the composite scalars. Comments regarding extending work to higher orders and concerning the symmetry-violating solutions to the fermion Schwinger-Dyson equation are given in this paper

  8. Action-based effects on music perception

    OpenAIRE

    Maes, Pieter-Jan; Leman, Marc; Palmer, Caroline; Wanderley, Marcelo M.

    2014-01-01

    The classical, disembodied approach to music cognition conceptualizes action and perception as separate, peripheral processes. In contrast, embodied accounts of music cognition emphasize the central role of the close coupling of action and perception. It is a commonly established fact that perception spurs action tendencies. We present a theoretical framework that captures the ways in which the human motor system and its actions can reciprocally influence the perception of music. The cornerst...

  9. Action-based effects on music perception

    OpenAIRE

    Pieter-Jan eMaes; Marc eLeman; Caroline ePalmer; Marcelo eWanderley

    2014-01-01

    The classical, disembodied approach to music cognition conceptualizes action and perception as separate, peripheral phenomena. In contrast, embodied accounts to music cognition emphasize the central role of the close coupling of action and perception. It is a commonly established fact that perception spurs action tendencies. We present a theoretical framework capturing the ways that the human motor system, and the actions it produces, can reciprocally influence the perception of music. The co...

  10. From action intentions to action effects: how does the sense of agency come about?

    Directory of Open Access Journals (Sweden)

    Valérian eChambon

    2014-05-01

    Full Text Available Sense of agency refers to the feeling of controlling an external event through one’s own action. On one influential view, agency depends on how predictable the consequences of one’s action are, getting stronger as the match between predicted and actual effect of an action gets closer. Thus, sense of agency arises when external events that follow our action are consistent with predictions of action effects made by the motor system while we perform or simply intend to perform an action. According to this view, agency is inferred retrospectively, after an action has been performed and its consequences are known. In contrast, little is known about whether and how internal processes involved in the selection of actions may influence subjective sense of control, in advance of the action itself, and irrespective of effect predictability. In this article, we review several classes of behavioural and neuroimaging data suggesting that earlier processes, linked to fluency of action selection, prospectively contribute to sense of agency. These findings have important implications for better understanding human volition and abnormalities of action experience.

  11. Causal binding of actions to their effects.

    Science.gov (United States)

    Buehner, Marc J; Humphreys, Gruffydd R

    2009-10-01

    According to widely held views in cognitive science harking back to David Hume, causality cannot be perceived directly, but instead is inferred from patterns of sensory experience, and the quality of these inferences is determined by perceivable quantities such as contingency and contiguity. We report results that suggest a reversal of Hume's conjecture: People's sense of time is warped by the experience of causality. In a stimulus-anticipation task, participants' response behavior reflected a shortened experience of time in the case of target stimuli participants themselves had generated, relative to equidistant, equally predictable stimuli they had not caused. These findings suggest that causality in the mind leads to temporal binding of cause and effect, and extend and generalize beyond earlier claims of intentional binding between action and outcome.

  12. Boundary Effective Action for Quantum Hall States

    Science.gov (United States)

    Gromov, Andrey; Jensen, Kristan; Abanov, Alexander G.

    2016-03-01

    We consider quantum Hall states on a space with boundary, focusing on the aspects of the edge physics which are completely determined by the symmetries of the problem. There are four distinct terms of Chern-Simons type that appear in the low-energy effective action of the state. Two of these protect gapless edge modes. They describe Hall conductance and, with some provisions, thermal Hall conductance. The remaining two, including the Wen-Zee term, which contributes to the Hall viscosity, do not protect gapless edge modes but are instead related to the local boundary response fixed by symmetries. We highlight some basic features of this response. It follows that the coefficient of the Wen-Zee term can change across an interface without closing a gap or breaking a symmetry.

  13. Motor imagery during action observation modulates automatic imitation effects in rhythmical actions

    Directory of Open Access Journals (Sweden)

    Daniel Lloyd Eaves

    2014-02-01

    Full Text Available We have previously shown that passively observing a task-irrelevant rhythmical action can bias the cycle time of a subsequently executed rhythmical action. Here we use the same paradigm to investigate the impact of different forms of motor imagery (MI during action observation (AO on this automatic imitation (AI effect. Participants saw a picture of the instructed action followed by a rhythmical distractor movie, wherein cycle time was subtly manipulated across trials. They then executed the instructed rhythmical action. When participants imagined performing the instructed action in synchrony with the distractor action (AO + MI, a strong imitation bias was found that was significantly greater than in our previous study. The bias was pronounced equally for compatible and incompatible trials, wherein observed and imagined actions were different in type (e.g., face washing vs. painting or plane of movement, or both. In contrast, no imitation bias was observed when MI conflicted with AO. In Experiment 2, motor execution synchronised with AO produced a stronger imitation bias compared to AO + MI, showing an advantage in synchronisation for overt execution over MI. Furthermore, the bias was stronger when participants synchronised the instructed action with the distractor movie, compared to when they synchronised the distractor action with the distractor movie. Although we still observed a significant bias in the latter condition, this finding indicates a degree of specificity in AI effects for the identity of the synchronised action. Overall, our data show that MI can substantially modulate the effects of AO on subsequent execution, wherein: (1 combined AO + MI can enhance AI effects relative to passive AO; (2 observed and imagined actions can be flexibly coordinated across different action types and planes; and (3 conflicting AO + MI can abolish AI effects. Therefore, combined AO + MI instructions should be considered in motor training and

  14. String effective actions, dualities, and generating solutions

    NARCIS (Netherlands)

    Chemissany, Wissam Ali

    2008-01-01

    This thesis covers in general two separate topics: the string e®ective actions and the geodesic motion of brane solutions. The main theme of the ¯rst topic, i.e., the string e®ective actions, is the construction of the abelian D-brane e®ective action. In the limit of constant ¯eld strengths this act

  15. The role of action effects in 12-month-olds' action control: a comparison of televised model and live model.

    Science.gov (United States)

    Klein, Annette M; Hauf, Petra; Aschersleben, Gisa

    2006-12-01

    The present study investigated differences in infant imitation after watching a televised model and a live model and addressed the issue of whether action effects influence infants' action control in both cases. In a 2x2 design, 12-month-old infants observed a live or a televised model performing a three-step action sequence, in which either the 2nd or the 3rd action step was combined with an acoustical action effect. We assumed that infants would use the observed action-effect relations for their own action control in the test phase afterwards. Even though results exhibited differences in the absolute amount of imitation between the two demonstration groups, both groups showed similar result patterns regarding the action effect manipulation: infants imitated the action step that was followed by a salient action effect more often and mostly as the first target action, emphasizing the important role of action effects in infants' action control. PMID:17138306

  16. The effective action in four-dimensional CDT

    CERN Document Server

    Gizbert-Studnicki, Jakub

    2015-01-01

    We present recent results concerning the measurement and analysis of the effective action in four-dimensional Causal Dynamical Triangulations. The action describes quantum fluctuations of the spatial volume of the CDT universe (or alternatively the scale factor) after integrating out other degrees of freedom. We use the covariance of volume fluctuations to measure and parametrize the effective action inside the de Sitter phase, also called the C phase. We show that the action is consistent with a simple discretization of the minisuperspace action (with a reversed overall sign). We discuss possible subleading corrections and show how to construct a more complicated effective action comprising both integer and half-integer discrete proper time layers. We introduce a new method of the effective action measurement based on the transfer matrix. We show that the results of the new method are fully consistent with the covariance matrix method inside the de Sitter phase. We use the new method to measure the effective...

  17. Effects of social intention on movement kinematics in cooperative actions

    Directory of Open Access Journals (Sweden)

    Francois eQuesque

    2013-10-01

    Full Text Available Optimal control models of biological movements are used to account for those internal variables that constrain voluntary goal-directed actions. They however do not take into account external environmental constraints as those associated to social intention. We investigated here the effects of the social context on kinematic characteristics of sequential actions consisting in placing an object on an initial pad (preparatory action before reaching and grasping as fast as possible the object to move it to another location (main action. Reach-to-grasp actions were performed either in an isolated condition or in the presence of a partner (audience effect, located in the near or far space (effect of shared reachable space, and who could intervene on the object in a systematic fashion (effect of social intention effect or not (effect of social uncertainty. Results showed an absence of audience effect but nevertheless an influence of the social context both on the main and the preparatory actions. In particular, a localized effect of shared reachable space was observed on the main action, which was smoother when performed within the reachable space of the partner. Furthermore, a global effect of social uncertainty was observed on both actions with faster and jerkier movements. Finally, social intention affected the preparatory action with higher wrist displacements and slower movements when the object was placed for the partner rather than placed for self-use. Overall, these results demonstrate specific effects of action space, social uncertainty and social intention on the planning of reach-to-grasp actions, in particular on the preparatory action, which was performed with no specific execution constraint. These findings underline the importance of considering the social context in optimal models of action control for human-robot interactions, in particular when focusing on the implementation of motor parameters required to afford intuitive

  18. Energy Transfer between Throats from a 10d Perspective

    CERN Document Server

    Harling, B v; Noguchi, T

    2007-01-01

    Strongly warped regions, also known as throats, are a common feature of the type IIB string theory landscape. If one of the throats is heated during cosmological evolution, the energy is subsequently transferred to other throats or to massless fields in the unwarped bulk of the Calabi-Yau orientifold. This energy transfer proceeds either by Hawking radiation from the black hole horizon in the heated throat or, at later times, by the decay of throat-localized Kaluza-Klein states. In both cases, we calculate in a 10d setup the energy transfer rate (respectively decay rate) as a function of the AdS scales of the throats and of their relative distance. Compared to existing results based on 5d models, we find a significant suppression of the energy transfer rates if the size of the embedding Calabi-Yau orientifold is much larger than the AdS radii of the throats. This effect can be partially compensated by a small distance between the throats. These results are relevant, e.g., for the analysis of reheating after b...

  19. Energy transfer between throats from a 10D perspective

    International Nuclear Information System (INIS)

    Strongly warped regions, also known as throats, are a common feature of the type IIB string theory landscape. If one of the throats is heated during cosmological evolution, the energy is subsequently transferred to other throats or to massless fields in the unwarped bulk of the Calabi-Yau orientifold. This energy transfer proceeds either by Hawking radiation from the black hole horizon in the heated throat or, at later times, by the decay of throat-localized Kaluza-Klein states. In both cases, we calculate in a 10d setup the energy transfer rate (respectively decay rate) as a function of the AdS scales of the throats and of their relative distance. Compared to existing results based on 5d models, we find a significant suppression of the energy transfer rates if the size of the embedding Calabi-Yau orientifold is much larger than the AdS radii of the throats. This effect can be partially compensated by a small distance between the throats. These results are relevant, e.g., for the analysis of reheating after brane inflation. Our calculation employs the dual gauge theory picture in which each throat is described by a strongly coupled 4d gauge theory, the degrees of freedom of which are localized at a certain position in the compact space

  20. Foundation ActionScript 30 Image Effects

    CERN Document Server

    Yard, Todd

    2009-01-01

    Flash has always been a tool for delivering compelling and unique experiences through dynamic visual presentation. The Flash platform has grown to include application development in Flex, video streaming with the Flash Media Server, and desktop delivery through AIR, but all of that content still comes down to pixels on the screen, and all of those pixels can be manipulated through the power of the ActionScript language. In this book, you will find in-depth coverage of the graphics capabilities of ActionScript 3.0: the enhanced drawing API in Flash Player 10 that allows you to draw vector shape

  1. Faddeev-Niemi Conjecture and Effective Action of QCD

    OpenAIRE

    Cho, Y. M.; Lee, H. W.; Pak, D. G.

    2001-01-01

    We calculate a one loop effective action of SU(2) QCD in the presence of the monopole background, and find a possible connection between the resulting QCD effective action and a generalized Skyrme-Faddeev action of the non-linear sigma model. The result is obtained using the gauge-independent decomposotion of the gauge potential into the topological degrees which describes the non-Abelian monopoles and the local dynamical degrees of the potential, and integrating out all the dynamical degrees...

  2. Kaluza-Klein monopole and 5-brane effective actions

    NARCIS (Netherlands)

    Eyras, E; Lozano, Y

    2000-01-01

    We review the construction of the Kaluza-Klein monopole of the Type IIA theory in the most general case of a massive background, as well as its relation via T-duality with the Type IIB NS-5-brane. This last effective action is shown to be related by S-duality to the D5-brane effective action. [GRAPH

  3. Conformally covariant operators and effective action in external gravitational field

    International Nuclear Information System (INIS)

    The n-dimensional expressions for the second order conformally covariant differentional operators acting on vector and tensor fields and for the fourth order conformally covariant operator acting on scalar fields are obtained. For the fourth order operator one-loop effective action is evaluated in four dimensions. The possibility of effective action evaluation for other conformally covariant operators is discussed

  4. Effective action for hard thermal loops in gravitational fields

    Directory of Open Access Journals (Sweden)

    R.R. Francisco

    2016-05-01

    Full Text Available We examine, through a Boltzmann equation approach, the generating action of hard thermal loops in the background of gravitational fields. Using the gauge and Weyl invariance of the theory at high temperature, we derive an explicit closed-form expression for the effective action.

  5. The quartic effective action of the heterotic string and supersymmetry

    NARCIS (Netherlands)

    Bergshoeff, E.A.; Roo, M. de

    1989-01-01

    We present the supersymmetric quartic effective action for the heterotic string which follows from the supersymmetrization of the Yang-Mills and Lorentz Chern-Simons forms. This includes all bosonic terms in the action, and all bosonic contributions to the supersymmetry transformation rules, thereby

  6. Effective supergravity actions for flop transitions

    Energy Technology Data Exchange (ETDEWEB)

    Jarv, Laur; Mohaupt, Thomas; Saueressig, Frank E-mail: F.Saueressig@tpi.uni-jena.de

    2003-12-01

    We construct a family of five-dimensional gauged supergravity actions which describe flop transitions of M-theory compactified on Calabi-Yau three folds. While the vector multiplet sector can be treated exactly, we use the Wolf spaces X(1+N) = U(1+N,2)/(U(1+N) x U(2)) to model the universal hyper multiplet together with N charged hyper multiplets corresponding to winding states of the M2-brane. The metric, the Killing vectors and the moment maps of these spaces are obtained explicitly by using the superconformal quotient construction of quaternion-Kaehler manifolds. The inclusion of the extra hyper multiplets gives rise to a non-trivial scalar potential which is uniquely fixed by M-theory physics. (author)

  7. On the influence of reward on action-effect binding.

    Science.gov (United States)

    Muhle-Karbe, Paul S; Krebs, Ruth M

    2012-01-01

    Ideomotor theory states that the formation of anticipatory representations about the perceptual consequences of an action [i.e., action-effect (A-E) binding] provides the functional basis of voluntary action control. A host of studies have demonstrated that A-E binding occurs fast and effortlessly, yet little is known about cognitive and affective factors that influence this learning process. In the present study, we sought to test whether the motivational value of an action modulates the acquisition of A-E associations. To this end, we linked specific actions with monetary incentives during the acquisition of novel A-E mappings. In a subsequent test phase, the degree of binding was assessed by presenting the former effect stimuli as task-irrelevant response primes in a forced-choice response task, absent reward. Binding, as indexed by response priming through the former action-effects, was only found for reward-related A-E mappings. Moreover, the degree to which reward associations modulated the binding strength was predicted by individuals' trait sensitivity to reward. These observations indicate that the association of actions and their immediate outcomes depends on the motivational value of the action during learning, as well as on the motivational disposition of the individual. On a larger scale, these findings also highlight the link between ideomotor theories and reinforcement-learning theories, providing an interesting perspective for future research on anticipatory regulation of behavior.

  8. On the influence of reward on action-effect binding

    Directory of Open Access Journals (Sweden)

    Paul Simon Muhle-Karbe

    2012-11-01

    Full Text Available Ideomotor theory states that the formation of anticipatory representations about the perceptual consequences of an action (i.e. action-effect (A-E binding provides the functional basis of voluntary action control. A host of studies has demonstrated that A-E binding occurs fast and effortlessly, yet only little is known about cognitive and affective factors that influence this learning process. In the present study, we sought to test whether the motivational value of an action modulates the acquisition of A-E associations. To this end, we associated specific actions with monetary incentives during the acquisition of novel A-E mappings. In a subsequent test phase, the degree of binding was assessed by presenting the former effect stimuli as task-irrelevant response primes in a forced-choice response task in the absence of any reward. Binding, as indexed by response priming through the former action effects, was only found for reward-related A-E mappings. Moreover, the degree to which reward associations modulated the binding strength was predicted by individuals’ trait sensitivity to reward. These observations indicate that the association of actions and their immediate outcomes depends on the motivational value of the action during learning, as well as on the motivational disposition of the individual. On a larger scale, these findings also highlight the link between ideomotor theories and reinforcement-learning theories, providing an interesting perspective for future research on anticipatory regulation of behavior.

  9. On the influence of reward on action-effect binding.

    Science.gov (United States)

    Muhle-Karbe, Paul S; Krebs, Ruth M

    2012-01-01

    Ideomotor theory states that the formation of anticipatory representations about the perceptual consequences of an action [i.e., action-effect (A-E) binding] provides the functional basis of voluntary action control. A host of studies have demonstrated that A-E binding occurs fast and effortlessly, yet little is known about cognitive and affective factors that influence this learning process. In the present study, we sought to test whether the motivational value of an action modulates the acquisition of A-E associations. To this end, we linked specific actions with monetary incentives during the acquisition of novel A-E mappings. In a subsequent test phase, the degree of binding was assessed by presenting the former effect stimuli as task-irrelevant response primes in a forced-choice response task, absent reward. Binding, as indexed by response priming through the former action-effects, was only found for reward-related A-E mappings. Moreover, the degree to which reward associations modulated the binding strength was predicted by individuals' trait sensitivity to reward. These observations indicate that the association of actions and their immediate outcomes depends on the motivational value of the action during learning, as well as on the motivational disposition of the individual. On a larger scale, these findings also highlight the link between ideomotor theories and reinforcement-learning theories, providing an interesting perspective for future research on anticipatory regulation of behavior. PMID:23130005

  10. The internal anticipation of sensory action effects: when action induces FFA and PPA activity

    Directory of Open Access Journals (Sweden)

    Simone Kühn

    2010-06-01

    Full Text Available Voluntary action – in particular the ability to produce desired effects in the environment – is fundamental to human existence. According to ideomotor theory we can achieve goals in the environment by means of anticipating their outcomes. We aimed at providing neurophysiological evidence for the assumption that performing actions calls for the activation of brain areas associated with the sensory effects usually evoked by the actions. We conducted an fMRI study in which right and left button presses lead to the presentation of face and house pictures. We compared a baseline phase with the same phase after participants experienced the association between button presses and pictures. We found an increase in the parahippocampal place area (PPA for the response that has been associated with house pictures and fusiform face area (FFA for the response that has been coupled with face pictures. This observation constitutes support for ideomotor theory.

  11. Effective average action for gauge theories and exact evolution equations

    International Nuclear Information System (INIS)

    We propose a new nonperturbative evolution equation for Yang-Mills theories. It describes the scale dependence of an effective action. The running of the nonabelian gauge coupling in arbitrary dimension is computed. (orig.)

  12. Holographic RG flow and the quantum effective action

    International Nuclear Information System (INIS)

    The calculation of the full (renormalized) holographic action is undertaken in general Einstein-scalar theories. The appropriate formalism is developed and the renormalized effective action is calculated up to two derivatives in the metric and scalar operators. The holographic RG equations involve a generalized Ricci flow for the space-time metric as well as the standard β-function flow for scalar operators. Several examples are analyzed and the effective action is calculated. A set of conserved quantities of the holographic flow is found, whose interpretation is not yet understood. (Copyright copyright 2014 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

  13. 10D = eesti disainer + soome firma / Ilona Gurjanova

    Index Scriptorium Estoniae

    Gurjanova, Ilona, 1958-

    2006-01-01

    Koostööprojektist, mille tulemusena pidi valmima kümnel eesti disaineril soome mööblitootja poolt tellitud mööbliese, mille valmistab eesti tootja. 10D disainikonkursi võitjad: I koht -Igor Volkov, lastetool "Dixi", II - Martin Pärn, istepink "Kosta", Tarmo Luisk, pehme järi "Dog", ära märgiti Ilona Gurjanova graafiliselt kujundatud kahhelkivid ja ürituse tunnusgraafika

  14. Urban Heat Island Effect Actions - Neighborhood Data

    Data.gov (United States)

    Louisville Metro Government — The urban heat island effect — defined as the difference in temperature between the core of Louisville and its suburbs — contributes to heat-related illnesses and...

  15. Effect of mutagen combined action on Chlamydomonas reinhardtii cells. II

    International Nuclear Information System (INIS)

    The effect of UV radiation and UV radiation combined with alkylnitrosourea derivatives (N-methyl-N-nitrosourea and N-ethyl-N-nitrosourea) was observed on survival of cells of the algae Chlamydomonas reinhardtii. In particular, single parts were evaluated of the overall lethal effect - dying of cells before division and dying of cells after division. It was found that the combined action of low doses of UV radiation and alkylnitrosoureas result in a pronounced protective effect which manifests itself by a higher frequency of surviving cells than was that effected by the action of alkylnitrosoureas alone. As a result of combined action with higher doses of UV radiation this effect is lost, and the resultant values will come close to the theoretically anticipated values. This gradual transition from a protective to an additive effect mainly manifests itself by changes in the proportion of cells dying before division. (author)

  16. Radiosensitizers action on Iodine 131 therapeutical effect

    International Nuclear Information System (INIS)

    Present studies were aimed to research the possible application of a radiosensitizer, nicotinamide, to increase the therapeutical effect of radioiodine. There were used goitrous and normal rats with growing dose of Iodine 131, with and without simultaneous treatment with nicotinamide. The obtained results show that the nicotinamide treatment importantly increases the thyroid radio destructive effect induced by radioiodine. Under these experimental conditions, nicotinamide induces to a significant increase of thyroid vascularisation, without changes in the proteins ADP-ribosylation activity. These results show, for the first time, the radiosensitizer effect of nicotinamide in front of Iodine 131 and give the possibility of using it in the treatment of hyperthyroid or thyroid difference cancer patients. (author)

  17. Fractional Effective Action at strong electromagnetic fields

    CERN Document Server

    Kleinert, Hagen; Xue, She-Sheng

    2013-01-01

    In 1936, Weisskopf showed that for vanishing electric or magnetic fields the strong-field behavior of the one loop Euler-Heisenberg effective Lagrangian of quantum electro dynamics (QED) is logarithmic. Here we generalize this result for different limits of the Lorentz invariants \\(\\vec{E}^2-\\vec{B}^2\\) and \\(\\vec{B}\\cdot\\vec{E}\\). The logarithmic dependence can be interpreted as a lowest-order manifestation of an anomalous power behavior of the effective Lagrangian of QED, with critical exponents \\(\\delta=e^2/(12\\pi)\\) for spinor QED, and \\(\\delta_S=\\delta/4\\) for scalar QED.

  18. Background independent effective action from D=1 matrix model

    International Nuclear Information System (INIS)

    We derive the background independent form of the Das-Jevicki action. The tachyon terms are given to all orders by a generally covariant form of the Das-Jevicki action. The graviton-dilaton sector is the usual low energy effective action. This enables us to examine questions such as the back reaction of the tachyon on the metric. In particular the reason why the usual Liouville term is an exact solution of the conformal invariance conditions, as well as the fact that it has no back reaction, become manifest. We comment on the propagation of a tachyonic perturbation in the background of a black-hole metric. (orig.)

  19. Renormalization and Effective Actions for General Relativity

    CERN Document Server

    Neugebohrn, Falk

    2007-01-01

    Quantum gravity is analyzed from the viewpoint of the renormalization group. The analysis is based on methods introduced by J. Polchinski concerning the perturbative renormalization with flow equations. In the first part of this work, the program of renormalization with flow equations is reviewed and then extended to effective field theories that have a finite UV cutoff. This is done for a scalar field theory by imposing additional renormalization conditions for some of the nonrenormalizable couplings. It turns out that one so obtains a statement on the predictivity of the effective theory at scales far below the UV cutoff. In particular, nonrenormalizable theories can be treated without problems in the proposed framework. In the second part, the standard covariant BRS quantization program for Euclidean Einstein gravity is applied. A momentum cutoff regularization is imposed and the resulting violation of the Slavnov-Taylor identities is discussed. Deriving Polchinski's renormalization group equation for Eucl...

  20. Renormalization and effective actions for general relativity

    Energy Technology Data Exchange (ETDEWEB)

    Neugebohrn, F.

    2007-05-15

    Quantum gravity is analyzed from the viewpoint of the renormalization group. The analysis is based on methods introduced by J. Polchinski concerning the perturbative renormalization with flow equations. In the first part of this work, the program of renormalization with flow equations is reviewed and then extended to effective field theories that have a finite UV cutoff. This is done for a scalar field theory by imposing additional renormalization conditions for some of the nonrenormalizable couplings. It turns out that one so obtains a statement on the predictivity of the effective theory at scales far below the UV cutoff. In particular, nonrenormalizable theories can be treated without problems in the proposed framework. In the second part, the standard covariant BRS quantization program for Euclidean Einstein gravity is applied. A momentum cutoff regularization is imposed and the resulting violation of the Slavnov-Taylor identities is discussed. Deriving Polchinski's renormalization group equation for Euclidean quantum gravity, the predictivity of effective quantum gravity at scales far below the Planck scale is investigated with flow equations. A fine-tuning procedure for restoring the violated Slavnov-Taylor identities is proposed and it is argued that in the effective quantum gravity context, the restoration will only be accomplished with finite accuracy. Finally, the no-cutoff limit of Euclidean quantum gravity is analyzed from the viewpoint of the Polchinski method. It is speculated whether a limit with nonvanishing gravitational constant might exist where the latter would ultimatively be determined by the cosmological constant and the masses of the elementary particles. (orig.)

  1. Perception, action, and Roelofs effect: a mere illusion of dissociation.

    Directory of Open Access Journals (Sweden)

    Paul Dassonville

    2004-11-01

    Full Text Available A prominent and influential hypothesis of vision suggests the existence of two separate visual systems within the brain, one creating our perception of the world and another guiding our actions within it. The induced Roelofs effect has been described as providing strong evidence for this perception/action dissociation: When a small visual target is surrounded by a large frame positioned so that the frame's center is offset from the observer's midline, the perceived location of the target is shifted in the direction opposite the frame's offset. In spite of this perceptual mislocalization, however, the observer can accurately guide movements to the target location. Thus, perception is prone to the illusion while actions seem immune. Here we demonstrate that the Roelofs illusion is caused by a frame-induced transient distortion of the observer's apparent midline. We further demonstrate that actions guided to targets within this same distorted egocentric reference frame are fully expected to be accurate, since the errors of target localization will exactly cancel the errors of motor guidance. These findings provide a mechanistic explanation for the various perceptual and motor effects of the induced Roelofs illusion without requiring the existence of separate neural systems for perception and action. Given this, the behavioral dissociation that accompanies the Roelofs effect cannot be considered evidence of a dissociation of perception and action. This indicates a general need to re-evaluate the broad class of evidence purported to support this hypothesized dissociation.

  2. Boldine action against the stannous chloride effect.

    Science.gov (United States)

    Reiniger, I W; Ribeiro da Silva, C; Felzenszwalb, I; de Mattos, J C; de Oliveira, J F; da Silva Dantas, F J; Bezerra, R J; Caldeira-de-Araújo, A; Bernardo-Filho, M

    1999-12-15

    Peumus boldus extract has been used in popular medicine in the treatment of biliar litiase, hepatic insufficiency and liver congestion. Its effects are associated to the substance boldine that is present in its extract. In the present work, we evaluated the influence of boldine both in: (i) the structural conformation of a plasmid pUC 9.1 through gel electrophoresis analysis; and in (ii) the survival of the strain of Escherichia coli AB1157 submitted to reactive oxygen species (ROS), generated by a Fenton like reaction, induced by stannous chloride. Our results show a reduction of the lethal effect induced by stannous chloride on the survival of the E. coli culture in the presence of boldine. The supercoiled form of the plasmid is not modified by stannous chloride in the presence of boldine. We suggest that the protection induced by boldine could be explained by its anti-oxidant mechanism. In this way, the boldine could be reacting with stannous ions, protecting them against the oxidation and, consequently, avoiding the generation of ROS. PMID:10624900

  3. Effective Action of Softly Broken Supersymmetric Theories

    CERN Document Server

    Nibbelink, S G; Nibbelink, Stefan Groot; Nyawelo, Tino S.

    2007-01-01

    We study the renormalization of (softly) broken supersymmetric theories at the one loop level in detail. We perform this analysis in a superspace approach in which the supersymmetry breaking interactions are parameterized using spurion insertions. We comment on the uniqueness of this parameterization. We compute the one loop renormalization of such theories by calculating superspace vacuum graphs with multiple spurion insertions. To preform this computation efficiently we develop algebraic properties of spurion operators, that naturally arise because the spurions are often surrounded by superspace projection operators. Our results are general apart from the restrictions that higher super covariant derivative terms and some finite effects due to non-commutativity of superfield dependent mass matrices are ignored. One of the soft potentials induces renormalization of the Kaehler potential.

  4. Stratospheric ozone loss, ultraviolet effects and action spectroscopy

    Science.gov (United States)

    Coohill, Thomas P.

    The major effect of stratospheric ozone loss will be an increase in the amount of ultraviolet radiation reaching the ground. This increase will be entirely contained within the UV-B (290-320nm). How this will impact life on Earth will be determined by the UV-B photobiology of exposed organisms, including humans. One of the analytical methods useful in estimating these effects is Action Spectroscopy (biological effect as a function of wavelength). Carefully constructed action spectra will allow us to partially predict the increase in bio-effect due to additional UV exposure. What effect this has on the organism and the system in which the organism resides is of paramount importance. Suitable action spectra already exist for human skin cancer, human cell mutation and killing, and for one immune response. Comprehensive and widely applicable action spectra for terrestrial and aquatic plant responses are being generated but are not yet suitable for extensive analysis. There is little data available for animals, other than those experiments completed in the laboratory as model systems for human studies. Some polychromatic action spectra have proven useful in determining the possible impact of ozone loss on biological systems. The pitfalls and limits of this approach will be addressed.

  5. On the new definition of off-shell effective action

    International Nuclear Information System (INIS)

    We analyze the recently proposed definition of the off-shell, gauge invariant, gauge-independent, effective action GAMMA, utilizing an invariant metric on the field space. It is shown how to establish correspondence between GAMMA and the standard effective action, calculated in some particular (Landau-type) gauge. Several examples are explicitly discussed, including Yang-Mills theory, the effective potential in scalar QED, and one-loop quantum gravity. Generalization to the case of super-invariant theories (e.g. super-Yang Mills and supergravity) is also presented. (orig.)

  6. Early markers of ongoing action-effect learning

    Directory of Open Access Journals (Sweden)

    Hannes eRuge

    2012-11-01

    Full Text Available Acquiring knowledge about the relationship between stimulus conditions, one’s own actions, and the resulting consequences or effects, is one prerequisite for intentional action. Previous studies have shown that such contextualized associations between actions and their effects (S-R-E associations can be picked up very quickly. The present study examined how such weakly practiced associations might affect overt behavior during the process of initial learning and during subsequent retrieval, and how these two measures are inter-related. We examined incidental (S-R-E learning in the context of trial-and-error S-R learning and in the context of instruction-based S-R learning. Furthermore, as a control condition, common outcome (CO learning blocks were included in which all responses produced one common sound effect, hence precluding differential (S-R-E learning. Post-learning retrieval of R-E associations was tested by re-using previously produced sound effects as novel imperative stimuli combined with actions that were either compatible or incompatible with the previously encountered R-E mapping. The central result was that the size of the compatibility effect could be predicted by the size of relative response slowing during ongoing learning in the preceding acquisition phase, both in trial-and-error learning and in instruction-based learning. Importantly, this correlation was absent for the common outcome control condition, precluding accounts based on unspecific factors. Instead, the results suggest that differential outcomes are ‘actively’ integrated into action planning and that this takes additional planning time. We speculate that this might be especially true for weakly practiced (S-R-E associations before an initial goal-directed action mode transitions into a more stimulus-based action mode.

  7. The Geometric Construction of WZW Effective Action in Noncommutative Manifold

    Institute of Scientific and Technical Information of China (English)

    HOU BoYu; WANG YongQiang; YANG ZhanYing; YUE RuiHong

    2002-01-01

    By constructing close-one-cochain density in the gauge group space we get the Wess Zumino Witten(WZW) effective Lagrangian on high-dimensional noncommutative space. Especially consistent anomalies derived fromthis WZW effective action in noncommutative four-dimensional space coincide with those obtained by L. Bonora etc.(hep-th /0002210).

  8. The Geometric Construction of WZW Effective Action in Noncommutative Manifold

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    By constructing close-one-cochain density Ω12n in the gauge group space we get the Wess-Zumino-Witten (WZW) effective Lagrangian on high-dimensional noncommutative space.Especially consistent anomalies derived from this WZW effective action in noncommutative four-dimensional space coincide with those obtained by L.Bonora etc.(het-th/0002210).

  9. Non-dissipative hydrodynamics: Effective actions versus entropy current

    CERN Document Server

    Bhattacharya, Jyotirmoy; Rangamani, Mukund

    2012-01-01

    While conventional hydrodynamics incorporating dissipative effects is hard to derive from an action principle, it is nevertheless possible to construct classical actions when the dissipative terms are switched off. In this note we undertake a systematic exploration of such constructions from an effective field theory approach and argue for the existence of non-trivial second order non-dissipative hydrodynamics involving pure energy-momentum transport. We find these fluids to be characterized by five second-order transport coefficients based on the effective action (a three parameter family is Weyl invariant). On the other hand since all flows of such fluids are non-dissipative, they entail zero entropy production; one can therefore understand them using the entropy current formalism which has provided much insight into hydrodynamic transport. An analysis of the most general stress tensor with zero entropy production however turns out to give a seven parameter family of non-dissipative hydrodynamics (a four pa...

  10. Boundary Conditions for NHEK through Effective Action Approach

    Institute of Scientific and Technical Information of China (English)

    CHEN Bin; NING Bo; ZHANG Jia-Ju

    2012-01-01

    We study the asymptotic symmetry group (ASG) of the near horizon geometry of extreme Kerr black hole through the effective action approach developed by Porfyriadis and Wilczek (arXiv:1007.1031v1[gr qc]).By requiring a finite boundary effective action,we derive a new set of asymptotic Killing vectors and boundary conditions,which are much more relaxed than the ones proposed by Matsuo Y et al.[Nucl.Phys.B 825 (2010) 231],and still allow a copy of a conformal group as its ASG.In the covariant formalism,the asymptotic charges are finite,with the corresponding central charge vanishing.By using the quasi-local charge and introducing a plausible cut-off,we find that the higher order terms of the asymptotic Killing vectors,which could not be determined through the effective action approach,contribute to the central charge as well.We also show that the boundary conditions suggested by Guica et al.[Phys.Rev.D 80 (2009)124008] lead to a divergent first-order boundary effective action.%We study the asymptotic symmetry group (ASG) of the near horizon geometry of extreme Kerr black hole through the effective action approach developed by Porfyriadis and Wilczek (arXiv:1007.1031vl[gr qc]). By requiring a finite boundary effective action, we derive a new set of asymptotic Killing vectors and boundary conditions, which are much more relaxed than the ones proposed by Matsuo Y et al. [Nucl. Phys. B 825 (2010) 231], and still allow a copy of a conformal group as its ASG. In the covariant formalism, the asymptotic charges are finite, with the corresponding central charge vanishing. By using the quasi-local charge and introducing a plausible cut-off, we find that the higher order terms of the asymptotic Killing vectors, which could not be determined through the effective action approach, contribute to the central charge as well. We also show that the boundary conditions suggested by Guica et al. [Phys. Rev. D 80 (2009) 124008] lead to a divergent first-order boundary effective action.

  11. Brane Effective Actions, Kappa-Symmetry and Applications

    CERN Document Server

    Simon, Joan

    2011-01-01

    This is a review on brane effective actions, their symmetries and some of its applications. Its first part uncovers the Green-Schwarz formulation of single M- and D-brane effective actions focusing on kinematical aspects : the identification of their degrees of freedom, the importance of world volume diffeomorphisms and kappa symmetry, to achieve manifest spacetime covariance and supersymmetry, and the explicit construction of such actions in arbitrary on-shell supergravity backgrounds. Its second part deals with applications. First, the use of kappa symmetry to determine supersymmetric world volume solitons. This includes their explicit construction in flat and curved backgrounds, their interpretation as BPS states carrying (topological) charges in the supersymmetry algebra and the connection between supersymmetry and hamiltonian BPS bounds. When available, I emphasise the use of these solitons as constituents in microscopic models of black holes. Second, the use of probe approximations to infer about non-tr...

  12. Effective action for the field equations of charged black holes

    International Nuclear Information System (INIS)

    We consistently reduce the equations of motion for the bosonic N = 2 supergravity action, using a multi-centered black hole ansatz for the metric. This reduction is done in a general, non-supersymmetric setup, in which we extend concepts of BPS black hole technology. First we obtain a more general form of the black hole potential, as part of an effective action for both the scalars and the vectors in the supergravity theory. Furthermore, we show that there are extra constraints specifying the solution, which we calculate explicitly. In the literature, these constraints have already been studied in the one-center case. We also show that the effective action we obtain for non-static metrics can be linked to the 'entropy function' for the spherically symmetric case, as defined by Sen (2005 J. High Energy Phys. JHEP09(2005)038) and Cardoso et al (2007 J. High Energy Phys. JHEP03(2007)085)

  13. Effective action approach to wave propagation in scalar QED plasmas

    CERN Document Server

    Shi, Yuan; Qin, Hong

    2016-01-01

    A relativistic quantum field theory with nontrivial background fields is developed and applied to study waves in plasmas. The effective action of the electromagnetic 4-potential is calculated ab initio from the standard action of scalar QED using path integrals. The resultant effective action is gauge invariant and contains nonlocal interactions, from which gauge bosons acquire masses without breaking the local gauge symmetry. To demonstrate how the general theory can be applied, we study a cold unmagnetized plasma and a cold uniformly magnetized plasma. Using these two examples, we show that all linear waves well-known in classical plasma physics can be recovered from relativistic quantum results when taking the classical limit. In the opposite limit, classical wave dispersion relations are modified substantially. In unmagnetized plasmas, longitudinal waves propagate with nonzero group velocities even when plasmas are cold. In magnetized plasmas, anharmonically spaced Bernstein waves persist even when plasma...

  14. Anomalous effective action, Noether current, Virasoro algebra and Horizon entropy

    Energy Technology Data Exchange (ETDEWEB)

    Majhi, Bibhas Ranjan [IUCAA, Ganeshkhind, Pune University Campus, Post Bag 4, Pune (India); Hebrew University of Jerusalem, Racah Institute of Physics, Jerusalem (Israel); Chakraborty, Sumanta [IUCAA, Ganeshkhind, Pune University Campus, Post Bag 4, Pune (India)

    2014-05-15

    Several investigations show that in a very small length scale there exist corrections to the entropy of black hole horizon. Due to fluctuations of the background metric and the external fields the action incorporates corrections. In the low energy regime, the one-loop effective action in four dimensions leads to trace anomaly. We start from the Noether current corresponding to the Einstein-Hilbert plus the one-loop effective action to calculate the charge for the diffeomorphisms which preserve the Killing horizon structure. Then a bracket for the charges is calculated. We show that the Fourier modes of the bracket are exactly similar to the Virasoro algebra. Then using the Cardy formula the entropy is evaluated. Finally, the explicit terms of the entropy expression is calculated for a classical background. It turns out that the usual expression for the entropy; i.e. the Bekenstein-Hawking form, is not modified. (orig.)

  15. Effective action for a quantum scalar field in warped spaces

    Energy Technology Data Exchange (ETDEWEB)

    Hoff da Silva, J.M.; Mendonca, E.L.; Scatena, E. [Universidade Estadual Paulista ' ' Julio de Mesquita Filho' ' -UNESP, Departamento de Fisica e Quimica, Guaratingueta, SP (Brazil)

    2015-11-15

    We investigate the one-loop corrections, at zero as well as finite temperature, of a scalar field taking place in a braneworld motivated warped background. After to reach a well-defined problem, we calculate the effective action with the corresponding quantum corrections to each case. (orig.)

  16. Action Research: Effective Marketing Strategies for a Blended University Program

    Science.gov (United States)

    Cook, Ruth Gannon; Ley, Kathryn

    2008-01-01

    This action research study investigated a marketing plan based on collaboration among a program faculty team and other organizational units for a graduate professional program. From its inception through the second year of operation, program enrollment increased due to the marketing plan based on an effective approach grounded in simple marketing…

  17. Finiteness of the Coulomb gauge QCD perturbative effective action

    Energy Technology Data Exchange (ETDEWEB)

    Andraši, A., E-mail: aandrasi@irb.hr [Vlaška 58, Zagreb (Croatia); Taylor, J.C., E-mail: jct@damtp.cam.ac.uk [DAMTP, University of Cambridge, Cambridge (United Kingdom)

    2015-05-15

    At 2-loop order in the Coulomb gauge, individual Feynman graphs contributing to the effective action have energy divergences. It is proved that these cancel in suitable combinations of graphs. This has previously been shown only for transverse external fields. The calculation results in a generalization of the Christ–Lee term which was inserted into the Hamiltonian.

  18. Finiteness of the Coulomb gauge QCD perturbative effective action

    CERN Document Server

    Andrasi, A

    2015-01-01

    At 2-loop order in the Coulomb gauge, individual Feynman graphs contributing to the effective action have energy divergences. It is proved that these cancel in suitable combinations of graphs. This has previously been shown only for transverse external fields. The calculation results in a generalization of the Christ-Lee term which was inserted into the Hamiltonian.

  19. Boundary Conditions for NHEK through Effective Action Approach

    International Nuclear Information System (INIS)

    We study the asymptotic symmetry group (ASG) of the near horizon geometry of extreme Kerr black hole through the effective action approach developed by Porfyriadis and Wilczek (arXiv:1007.1031v1[gr-qc]). By requiring a finite boundary effective action, we derive a new set of asymptotic Killing vectors and boundary conditions, which are much more relaxed than the ones proposed by Matsuo Y et al. [Nucl. Phys. B 825 (2010) 231], and still allow a copy of a conformal group as its ASG. In the covariant formalism, the asymptotic charges are finite, with the corresponding central charge vanishing. By using the quasi-local charge and introducing a plausible cut-off, we find that the higher order terms of the asymptotic Killing vectors, which could not be determined through the effective action approach, contribute to the central charge as well. We also show that the boundary conditions suggested by Guica et al. [Phys. Rev. D 80 (2009) 124008] lead to a divergent first-order boundary effective action. (the physics of elementary particles and fields)

  20. Effect and mode of action of some systemic nematicides

    NARCIS (Netherlands)

    Bunt, J.A.

    1975-01-01

    In this study, nematicidal effects, mode of action and specific characters of some systemic nematicides were studied, in search of substitutes for the widely used soil fumigants that require high dosages. The thesis comprises:- a review of literature,- development of techniques,- a test for nematici

  1. Constraining the effective action by a method of external sources

    CERN Document Server

    Garbrecht, Bjorn

    2015-01-01

    We propose a novel method of evaluating the effective action, wherein the physical one- and two-point functions are obtained in the limit of non-vanishing external sources. We illustrate the self-consistency of this method by recovering the usual 2PI effective action due to Cornwall, Jackiw and Tomboulis, differing only by the fact that the saddle-point evaluation of the path integral is performed along the extremal quantum, rather than classical, path. As such, this approach is of particular relevance to situations where the dominant quantum and classical paths are non-perturbatively far away from one-another. A pertinent example is the decay of false vacua in radiatively-generated potentials, as may occur for the electroweak vacuum of the Standard Model. In addition, we describe how the external sources may instead be chosen so as to yield the two-particle-point-irreducible (2PPI) effective action of Coppens and Verschelde. Finally, in the spirit of the symmetry-improved effective action of Pilaftsis and Te...

  2. Effective action approach to dynamical generation of fermion mixing

    CERN Document Server

    Blasone, Massimo; Smaldone, Luca

    2016-01-01

    In this paper we discuss a mechanism for the dynamical generation of flavor mixing, in the framework of the Nambu--Jona Lasinio model. Our approach is illustrated both with the conventional operatorial formalism and with functional integral and ensuing one-loop effective action. The results obtained are briefly discussed.

  3. Effective QED Actions Representations, Gauge Invariance, Anomalies and Mass Expansions

    CERN Document Server

    Deser, Stanley D; Seminara, D

    1998-01-01

    We analyze and give explicit representations for the effective abelian vector gauge field actions generated by charged fermions with particular attention to the thermal regime in odd dimensions, where spectral asymmetry can be present. We show, through $\\zeta-$function regularization, that both small and large gauge invariances are preserved at any temperature and for any number of fermions at the usual price of anomalies: helicity/parity invariance will be lost in even/odd dimensions, and in the latter even at zero mass. Gauge invariance dictates a very general ``Fourier'' representation of the action in terms of the holonomies that carry the novel, large gauge invariant, information. We show that large (unlike small) transformations and hence their Ward identities, are not perturbative order-preserving, and clarify the role of (properly redefined) Chern-Simons terms in this context. From a powerful representation of the action in terms of massless heat kernels, we are able to obtain rigorous gauge invariant...

  4. Effect of mutagen combined action on Chlamydomonas Reinhardtii cells. I

    International Nuclear Information System (INIS)

    The effect was investigated of single and combined actions of alkylnitrosourea derivatives (N-methyl-N-nitrosourea and N-ethyl-N-nitrosourea) and UV-radiation on the survival of cells of Chlamydomonas reinhardtii algae in dependence on the sequence of application of mutagens and on the given conditions of cultivation following mutagen activity. In particular, the single phases were investigated of the total lethal effect, i.e., the death of cells before division and their death after division. The most pronounced changes in dependence on the sequence of application of mutagens and on the given conditions of cultivation were noted in cell death before division. In dependence on the sequence of application of mutagens, the effect of the combined action on the survival of cells changed from an additive (alkylnitrosourea + UV-radiation) to a protective effect (UV-radiation + alkylnitrosourea). (author)

  5. Computing the effective action with the functional renormalization group

    Energy Technology Data Exchange (ETDEWEB)

    Codello, Alessandro [CP3-Origins and the Danish IAS University of Southern Denmark, Odense (Denmark); Percacci, Roberto [SISSA, Trieste (Italy); INFN, Sezione di Trieste, Trieste (Italy); Rachwal, Leslaw [Fudan University, Department of Physics, Center for Field Theory and Particle Physics, Shanghai (China); Tonero, Alberto [ICTP-SAIFR and IFT, Sao Paulo (Brazil)

    2016-04-15

    The ''exact'' or ''functional'' renormalization group equation describes the renormalization group flow of the effective average action Γ{sub k}. The ordinary effective action Γ{sub 0} can be obtained by integrating the flow equation from an ultraviolet scale k = Λ down to k = 0. We give several examples of such calculations at one-loop, both in renormalizable and in effective field theories. We reproduce the four-point scattering amplitude in the case of a real scalar field theory with quartic potential and in the case of the pion chiral Lagrangian. In the case of gauge theories, we reproduce the vacuum polarization of QED and of Yang-Mills theory. We also compute the two-point functions for scalars and gravitons in the effective field theory of scalar fields minimally coupled to gravity. (orig.)

  6. Action video game training reduces the Simon Effect.

    Science.gov (United States)

    Hutchinson, Claire V; Barrett, Doug J K; Nitka, Aleksander; Raynes, Kerry

    2016-04-01

    A number of studies have shown that training on action video games improves various aspects of visual cognition including selective attention and inhibitory control. Here, we demonstrate that action video game play can also reduce the Simon Effect, and, hence, may have the potential to improve response selection during the planning and execution of goal-directed action. Non-game-players were randomly assigned to one of four groups; two trained on a first-person-shooter game (Call of Duty) on either Microsoft Xbox or Nintendo DS, one trained on a visual training game for Nintendo DS, and a control group who received no training. Response times were used to contrast performance before and after training on a behavioral assay designed to manipulate stimulus-response compatibility (the Simon Task). The results revealed significantly faster response times and a reduced cost of stimulus-response incompatibility in the groups trained on the first-person-shooter game. No benefit of training was observed in the control group or the group trained on the visual training game. These findings are consistent with previous evidence that action game play elicits plastic changes in the neural circuits that serve attentional control, and suggest training may facilitate goal-directed action by improving players' ability to resolve conflict during response selection and execution. PMID:26238760

  7. Action video game training reduces the Simon Effect.

    Science.gov (United States)

    Hutchinson, Claire V; Barrett, Doug J K; Nitka, Aleksander; Raynes, Kerry

    2016-04-01

    A number of studies have shown that training on action video games improves various aspects of visual cognition including selective attention and inhibitory control. Here, we demonstrate that action video game play can also reduce the Simon Effect, and, hence, may have the potential to improve response selection during the planning and execution of goal-directed action. Non-game-players were randomly assigned to one of four groups; two trained on a first-person-shooter game (Call of Duty) on either Microsoft Xbox or Nintendo DS, one trained on a visual training game for Nintendo DS, and a control group who received no training. Response times were used to contrast performance before and after training on a behavioral assay designed to manipulate stimulus-response compatibility (the Simon Task). The results revealed significantly faster response times and a reduced cost of stimulus-response incompatibility in the groups trained on the first-person-shooter game. No benefit of training was observed in the control group or the group trained on the visual training game. These findings are consistent with previous evidence that action game play elicits plastic changes in the neural circuits that serve attentional control, and suggest training may facilitate goal-directed action by improving players' ability to resolve conflict during response selection and execution.

  8. The end-state comfort effect facilitates joint action.

    Science.gov (United States)

    Herbort, Oliver; Koning, Arno; van Uem, Janet; G J Meulenbroek, Ruud

    2012-03-01

    Motor experts can accurately predict the future actions of others by observing their movements. This report describes three experiments that investigate such predictions in everyday object manipulations and test whether these predictions facilitate responses to the actions of others. Observing video excerpts showing an actor reaching for a vertically mounted dial, participants in Experiment 1 needed to predict how the actor would rotate it. Their predictions were specific to the direction and extent of the dial rotation and improved proportionate to the length of the video clip shown. Testing whether such predictions facilitate responses, in the subsequent experiments responders had to undo an actor's actions, back-rotating a dial (Exp 2) and a bar (Exp 3). The responders' actions were initiated faster when the actors' movements obeyed the so-called end-state comfort principle than when they did not. Our experiments show that humans exploit the end-state comfort effect to tweak their predictions of the future actions of others. The results moreover suggest that the precision of these predictions is mediated by perceptual learning rather than by motor simulation. PMID:22321453

  9. Effect of exercise on insulin action in human skeletal muscle

    DEFF Research Database (Denmark)

    Richter, Erik; Mikines, K J; Galbo, Henrik;

    1989-01-01

    The effect of 1 h of dynamic one-legged exercise on insulin action in human muscle was studied in 6 healthy young men. Four hours after one-legged knee extensions, a three-step sequential euglycemic hyperinsulinemic clamp combined with arterial and bilateral femoral vein catheterization...... was performed. Increased insulin action on glucose uptake was found in the exercised compared with the rested thigh at mean plasma insulin concentrations of 23, 40, and 410 microU/ml. Furthermore, prior contractions directed glucose uptake toward glycogen synthesis and increased insulin effects on thigh O2...... consumption and at some insulin concentrations on potassium exchange. In contrast, no change in insulin effects on limb exchange of free fatty acids, glycerol, alanine or tyrosine were found after exercise. Glycogen concentration in rested vastus lateralis muscle did not increase measurably during the clamp...

  10. Surgical removal of visceral adipose tissue: effects on insulin action.

    Science.gov (United States)

    Gabriely, Ilan; Barzilai, Nir

    2003-06-01

    Many studies have demonstrated that excess of visceral fat has deleterious effects on insulin action. Mainly, it has been shown to be associated with a decrease in hepatic and peripheral insulin sensitivity, which results in a clinical condition also known as insulin resistance. This report describes a novel experimental method that we employed in order to analyze the particular effects of visceral fat on insulin activity. By extracting visceral fat we were able to distinguish the specific role that it plays in insulin action, and to analyze its effects on the gene expression of a variety of fat-derived peptides, which may be considered to be (at least partially) mediators in the development of the metabolic syndrome and possibly diabetes mellitus. PMID:12762966

  11. Covariant effective action for a Galilean invariant quantum Hall system

    Science.gov (United States)

    Geracie, Michael; Prabhu, Kartik; Roberts, Matthew M.

    2016-09-01

    We construct effective field theories for gapped quantum Hall systems coupled to background geometries with local Galilean invariance i.e. Bargmann spacetimes. Along with an electromagnetic field, these backgrounds include the effects of curved Galilean spacetimes, including torsion and a gravitational field, allowing us to study charge, energy, stress and mass currents within a unified framework. A shift symmetry specific to single constituent theories constraints the effective action to couple to an effective background gauge field and spin connection that is solved for by a self-consistent equation, providing a manifestly covariant extension of Hoyos and Son's improvement terms to arbitrary order in m.

  12. Effective action for scalar fields in two-dimensional gravity

    International Nuclear Information System (INIS)

    We consider a general two-dimensional gravity model minimally or nonminimally coupled to a scalar field. The canonical form of the model is elucidated, and a general solution of the equations of motion in the massless case is reviewed. In the presence of a scalar field all geometric fields (zweibein and Lorentz connection) are excluded from the model by solving exactly their Hamiltonian equations of motion. In this way the effective equations of motion and the corresponding effective action for a scalar field are obtained. It is written in a Minkowskian space-time and does not include any geometric variables. The effective action arises as a boundary term and is nontrivial both for open and closed universes. The reason is that unphysical degrees of freedom cannot be compactly supported because they must satisfy the constraint equation. As an example we consider spherically reduced gravity minimally coupled to a massless scalar field. The effective action is used to reproduce the Fisher and Roberts solutions

  13. Field theory without Feynman diagrams: One-loop effective actions

    International Nuclear Information System (INIS)

    In this paper the connection between standard perturbation theory techniques and the new Bern-Kosower calculational rules for gauge theory is clarified. For one-loop effective actions of scalars, Dirac spinors, and vector bosons in a background gauge field, Bern-Kosower type rules are derived without the use of either string theory or Feynman diagrams. The effective action is written as a one-dimensional path integral, which can be calculated to any order in the gauge coupling; evaluation leads to Feynman parameter integrals directly, bypassing the usual algebra required from Feynman diagrams, and leading to compact and organized expressions. This formalism is valid off-shell, is explicitly gauge invariant, and can be extended to a number of other field theories. (orig.)

  14. Misunderstanding that the Effective Action is Convex under Broken Symmetry

    CERN Document Server

    Asanuma, Nobu-Hiko

    2016-01-01

    The widespread belief that the effective action is convex and has a flat bottom under broken global symmetry is shown to be wrong. We show spontaneous symmetry breaking necessarily accompanies non-convexity in the effective action for quantum field theory, or in the free energy for statistical mechanics, and clarify the magnitude of non-convexity. For quantum field theory, it is also explicitly proved that translational invariance breaks spontaneously when the system is in the non-convex region, and that different vacua of spontaneously broken symmetry cannot be superposed. As applications of non-convexity, we study the first-order phase transition which happens at the zero field limit of spontaneously broken symmetry, and we propose a simple model of phase coexistence which obeys the Born rule.

  15. One-loop effective actions and higher spins

    CERN Document Server

    Bonora, L; Prester, P Dominis; Giaccari, S; De Souza, B Lima; Stemberga, T

    2016-01-01

    The idea we advocate in this paper is that the one-loop effective action of a free (massive) field theory coupled to external sources (via conserved currents) contains complete information about the classical dynamics of such sources. We show many explicit examples of this fact for (scalar and fermion) free field theories in various dimensions $d=3,4,5,6$ coupled to (bosonic, completely symmetric) sources with a number of spins. In some cases we also provide compact formulas for any dimension. This paper is devoted to two-point correlators, so the one-loop effective action we construct contains only the quadratic terms and the relevant equations of motion for the sources we obtain are the linearized ones.

  16. The effective action in Einstein-Maxwell theory

    OpenAIRE

    Bastianelli, Fiorenzo; Davila, Jose Manuel; Schubert, Christian

    2008-01-01

    Considerable work has been done on the one-loop effective action in combined electromagnetic and gravitational fields, particularly as a tool for determining the properties of light propagation in curved space. After a short review of previous work, I present some recent results obtained using the worldline formalism. In particular, I will discuss various ways of generalizing the QED Euler-Heisenberg Lagrangian to the Einstein-Maxwell case.

  17. Effective actions from loop quantum cosmology: correspondence with higher curvature gravity

    Energy Technology Data Exchange (ETDEWEB)

    Date, Ghanashyam; Sengupta, Sandipan, E-mail: shyam@imsc.res.i, E-mail: sandi@imsc.res.i [Institute of Mathematical Sciences, CIT Campus, Chennai 600 113 (India)

    2009-05-21

    Quantum corrections of certain types and relevant in certain regimes can be summarized in terms of an effective action calculable, in principle, from the underlying theory. The demands of symmetries, local form of terms and dimensional considerations limit the form of the effective action to a great extent leaving only the numerical coefficients to distinguish different underlying theories. The effective action can be restricted to particular symmetry sectors to obtain the corresponding, reduced effective action. Alternatively, one can also quantize a classically (symmetry) reduced theory and obtain the corresponding effective action. These two effective actions can be compared. As an example, we compare the effective action(s) known in isotropic loop quantum cosmology with the Lovelock actions, as well as with more general actions, specialized to homogeneous isotropic spacetimes and find that the mu-bar scheme is singled out.

  18. Brane Effective Actions, Kappa-Symmetry and Applications

    Directory of Open Access Journals (Sweden)

    Joan Simón

    2012-02-01

    Full Text Available This is a review on brane effective actions, their symmetries and some of their applications. Its first part covers the Green–Schwarz formulation of single M- and D-brane effective actions focusing on kinematical aspects: the identification of their degrees of freedom, the importance of world volume diffeomorphisms and kappa symmetry to achieve manifest spacetime covariance and supersymmetry, and the explicit construction of such actions in arbitrary on-shell supergravity backgrounds. Its second part deals with applications. First, the use of kappa symmetry to determine supersymmetric world volume solitons. This includes their explicit construction in flat and curved backgrounds, their interpretation as Bogomol’nyi–Prasad–Sommerfield (BPS states carrying (topological charges in the supersymmetry algebra and the connection between supersymmetry and Hamiltonian BPS bounds. When available, I emphasise the use of these solitons as constituents in microscopic models of black holes. Second, the use of probe approximations to infer about the non-trivial dynamics of strongly-coupled gauge theories using the anti de Sitter/conformal field theory (AdS/CFT correspondence. This includes expectation values of Wilson loop operators, spectrum information and the general use of D-brane probes to approximate the dynamics of systems with small number of degrees of freedom interacting with larger systems allowing a dual gravitational description. Its final part briefly discusses effective actions for N D-branes and M2-branes. This includes both Super-Yang-Mills theories, their higher-order corrections and partial results in covariantising these couplings to curved backgrounds, and the more recent supersymmetric Chern–Simons matter theories describing M2-branes using field theory, brane constructions and 3-algebra considerations.

  19. Using the Psychology of Language to Effectively Communicate Actionable Science

    Science.gov (United States)

    Hall, J. M.

    2014-12-01

    The words used to articulate science can have as significant a psychological impact on public perception as the data itself. It is therefore essential to utilize language that not only accurately relates the scientific information, but also effectively conveys a message that is congruent with the presenter's motivation for expressing the data. This is especially relevant for environmental subjects that are surrounded by emotionally charged, political discourses. For example are terms like catastrophe and disaster; while these words may accurately illustrate impartial scientific data, they will likely trigger psychological responses in audiences such as fear or denial that have a detrimental impact on the human decision making process. I propose a set of 5 key principles to assist in communicating data to the general public that both support the transfer of ideas and the presenter's intended psychological impact. 1) Articulate the underlying intentions that motivate the communication of data in a transparent manner 2) Use language congruent with the presenter's stated intentions 3) Maintain a neutral, non-judgmental attitude towards the complex human psychological and emotional dynamics present in a target audience 4) Demonstrate acceptance and compassion when analyzing past and present human actions that adversely affect the environment 5) Develop a perspective of non-attachment when proposing future actions and/or consequences of current human behaviors. The application of these 5 principles provides a framework to move from our current understanding of problems and solutions to effective physical action that allows us to gracefully adapt with our ever changing planet.

  20. Side effect of acting on the world: Acquisition of action-outcome statistic relation alters visual interpretation of action outcome

    Directory of Open Access Journals (Sweden)

    Takahiro eKawabe

    2013-09-01

    Full Text Available Humans can acquire the statistical features of the external world and employ them to control behaviors. Some external events occur in harmony with an agent’s action, and thus humans should also be able to acquire the statistical features between an action and its external outcome. We report that the acquired action-outcome statistical features alter the visual appearance of the action outcome. Pressing either of two assigned keys triggered visual motion whose direction was statistically biased either upward or downward, and observers judged the stimulus motion direction. Points of subjective equality (PSE for judging motion direction were shifted repulsively from the mean of the distribution associated with each key. Our Bayesian model accounted for the PSE shifts, indicating the optimal acquisition of the action-effect statistical relation. The PSE shifts were moderately attenuated when the action-outcome contingency was reduced. The Bayesian model again accounted for the attenuated PSE shifts. On the other hand, when the action-outcome contiguity was greatly reduced, the PSE shifts were greatly attenuated, and however, the Bayesian model could not accounted for the shifts. The results indicate that visual appearance can be modified by prediction based on the optimal acquisition of action-effect causal relation.

  1. PARENTS' AUTHORITY AND THE EFFECTIVENESS OF THEIR EDUCATIONAL ACTIONS

    Directory of Open Access Journals (Sweden)

    Romanowska-Tolloczko Anna

    2010-01-01

    Full Text Available Facing a gradual crisis of moral authority in the modern world, educationalists underline its importance in the education and upbringing process. The first and, for a long period of time, the most important authority for children are their parents, who often fail to understand the nature of their own significance and impact on the child. They often wrongly associate parental authority with unquestionable power and this faulty reasoning carries negative developmental implications as the child's submissiveness is not tantamount to acceptance and may result from his/her weakness or fear rather than from recognizing parental authority. This article is to emphasise that parents need to be fully aware of their own educational actions in the child upbringing process. It is important to understand that such actions affect the way parents are perceived by children. This article suggests a number of behaviours conducive to building and sustaining the sense of authority and respect as these features are fundamental in ensuring the effectiveness of educational actions undertaken by parents in the upbringing process.

  2. Maternal and child undernutrition: effective action at national level.

    Science.gov (United States)

    Bryce, Jennifer; Coitinho, Denise; Darnton-Hill, Ian; Pelletier, David; Pinstrup-Andersen, Per

    2008-02-01

    80% of the world's undernourished children live in just 20 countries. Intensified nutrition action in these countries can lead to achievement of the first Millennium Development Goal (MDG) and greatly increase the chances of achieving goals for child and maternal mortality (MDGs 4 and 5). Despite isolated successes in specific countries or for interventions--eg, iodised salt and vitamin A supplementation--most countries with high rates of undernutrition are failing to reach undernourished mothers and children with effective interventions supported by appropriate policies. This paper reports on an assessment of actions addressing undernutrition in the countries with the highest burden of undernutrition, drawing on systematic reviews and best-practice reports. Seven key challenges for addressing undernutrition at national level are defined and reported on: getting nutrition on the list of priorities, and keeping it there; doing the right things; not doing the wrong things; acting at scale; reaching those in need; data-based decisionmaking; and building strategic and operational capacity. Interventions with proven effectiveness that are selected by countries should be rapidly implemented at scale. The period from pregnancy to 24 months of age is a crucial window of opportunity for reducing undernutrition and its adverse effects. Programme efforts, as well as monitoring and assessment, should focus on this segment of the continuum of care. Nutrition resources should not be used to support actions unlikely to be effective in the context of country or local realities. Nutrition resources should not be used to support actions that have not been proven to have a direct effect on undernutrition, such as stand-alone growth monitoring or school feeding programmes. In addition to health and nutrition interventions, economic and social policies addressing poverty, trade, and agriculture that have been associated with rapid improvements in nutritional status should be

  3. The effective action approach applied to nuclear chiral sigma model

    International Nuclear Information System (INIS)

    The nuclear chiral sigma model of nuclear matter is considered by means of the Cornwall-Jackiw-tomboulis (CTJ) effective action. The method provides a very general framework for investigating many important problems: chiral symmetry in nuclear medium, energy density of nuclear ground state, nuclear Schwinger-Dyson (SD) equations, etc. It is shown that the SD equations for sigma-omega mixing are actually not present in this formalism. For numerical computation purposes the Hartree-Fock (HF) approximation for ground state energy density is also presented. (author). 26 refs

  4. Regular effective action of gauge field theory and quantum gravity

    Energy Technology Data Exchange (ETDEWEB)

    Baaklini, N.S.

    1987-05-15

    We present a perturbative formalism for the effective quantum action of a general Fermi-Bose field theory. We propose a unitary alternative to the conventional virtual ghost prescription for handling the functional integral of gauge fields, based on the functional space metric that is determined by the Dirac brackets of the canonical theory. A gauge-invariant Gaussian cutoff is introduced by extending the functional space metric into a regular counterpart. The regular one-loop contributions of a scalar field to the photon and the graviton self-energies are computed. The otherwise logarithmically divergent contributions are found, in our scheme, to be independent of cutoff.

  5. Constraining gravitational interactions in the M theory effective action

    CERN Document Server

    Basu, Anirban

    2013-01-01

    We consider purely gravitational interactions of the type D^{2k} R^4 in the effective action of M theory in 11 dimensional flat spacetime, where k \\geq 0. The duality between M theory on S^1 and type IIA string theory, and the structure of the dilaton dependence of string amplitudes, show that the only non-vanishing interactions in the M theory effective action have k=3n. The coefficient of the D^{6n} R^4 interaction in M theory is determined by the genus (n+1) string amplitude of the D^{6n} R^4 interaction in the type IIA theory. Focussing on the even-even spin structure part of the type IIA string amplitude, this coefficient is given by the type IIB genus (n+1) amplitude, which we constrain using supersymmetry, S-duality and maximal supergravity. The source terms of the Poisson equations satisfied by the S-duality invariant IIB couplings play a central role in the analysis. This procedure yields partial contributions to several multi-loop type IIB string amplitudes, from which we extract the coefficients of...

  6. Effective corrective actions to enhance operational safety of nuclear installations

    International Nuclear Information System (INIS)

    The safe operation of nuclear power plants around the world and the prevention of incidents in these installations remain key concerns for the nuclear community. In this connection the feedback of operating experience plays a major role: every nuclear plant operator needs to have a system in place to identify and feed back the lessons learned from operating experience and to implement effective corrective actions to prevent safety events from reoccurring. An effective operating experience programme also includes a proactive approach that is aimed at preventing the first-time occurrence of safety events. In April 2003, the IAEA issued the PROSPER guidelines for nuclear installations to strengthen and enhance their own operating experience process and for self-assessment on the effectiveness of the feedback process. Subsequently, in the course of the Operational Safety Review Teams missions conducted by the IAEA that focused on the operational safety practices of nuclear power plants, the IAEA enhanced the review of the operating experience in nuclear power plants by implementing a new module that is derived from these guidelines. In order to highlight the effective implementation of the operating experience programme and to provide practical assistance in this area, the IAEA organized workshops and conferences to discuss recent trends in operating experience. The IAEA also performed assistance and review missions at plants and corporate organizations. The IAEA is further developing advice and assistance on operating experience feedback programmes and is reporting on good practices. The present publication is the outcome of two years of coordinated effort involving the participation of experts of nuclear organizations in several Member States. It provides information and good practices for successfully establishing an effective corrective actions programme. This publication forms part of a series that develops the principles set forth in these guidelines

  7. Effective Action for Cosmological Scalar Fields at Finite Temperature

    CERN Document Server

    Cheung, Yeuk-Kwan E; Kang, Jin U; Kim, Jong Chol

    2015-01-01

    Scalar fields appear in many theories beyond the Standard Model of particle physics. In the early universe, they are exposed to extreme conditions, including high temperature and rapid cosmic expansion. Understanding their behavior in this environment is crucial to understand the implications for cosmology. We calculate the finite temperature effective action for the field expectation value in two particularly important cases, for damped oscillations near the ground state and for scalar fields with a flat potential. We find that the behavior in both cases can in good approximation be described by a complex valued effective potential that yields Markovian equations of motion. Near the potential minimum, we recover the solution to the well-known Langevin equation. For large field values we find a very different behavior, and our result for the damping coefficient significantly differs from the expressions given in the literature. We illustrate our results in a simple scalar model, for which we give analytic app...

  8. Dura’s Effect on Securities Class Actions

    Directory of Open Access Journals (Sweden)

    Scotland M. Duncan

    2008-12-01

    Full Text Available On April 19, 2005, the United States Supreme Court rendered a unanimous decision in Dura Pharmaceuticals, Inc. v. Broudo, which had been described as “the most important securities case in a decade.” Simply put, the decision raises the pleading standard for Rule 10b-5 cases asserting fraud-onthe-market; instead of requiring a showing of ex ante losses, such as inflation at the time of purchase, Dura requires a showing of ex post losses, such as market decline resulting from a corrective disclosure. This paper assesses the decision’s practical implications by examining and empirically testing whether the Supreme Court’s enhanced pleading requirements have impacted the frequency and magnitude of post-Reform Act (PSLRA class action securities cases. Specifically, this paper examines Dura’s effect on the filing and settling of cases, as well as on settlement amount. In particular, the results suggest that Dura, ceteris paribus, has had a statistically significant impact on both the filing and settlement of class actions, suggesting a reduction in frivolous litigation.

  9. Covariant computation of effective actions in Horava-Lifshitz gravity

    CERN Document Server

    D'Odorico, Giulio; Saueressig, Frank

    2015-01-01

    We initiate the systematic computation of the heat-kernel coefficients for Laplacian operators obeying anisotropic dispersion relations in curved spacetime. Our results correctly reproduce the limit where isotropy is restored and special anisotropic cases considered previously in the literature. Subsequently, the heat kernel is used to derive the scalar-induced one-loop effective action and beta functions of Horava-Lifshitz gravity. We identify the Gaussian fixed point which is supposed to provide the UV completion of the theory. In the present setting, this fixed point acts as an infrared attractor for the renormalization group flow of Newton's constant and the high-energy phase of the theory is screened by a Landau pole. We comment on the consequences of these findings for the renormalizability of the theory.

  10. Mephedrone: Public health risk, mechanisms of action, and behavioral effects.

    Science.gov (United States)

    Dybdal-Hargreaves, Nicholas F; Holder, Nicholas D; Ottoson, Paige E; Sweeney, Melanie D; Williams, Tyisha

    2013-08-15

    The recent shortage of 3,4-methylenedioxymethamphetamine (MDMA, Ecstasy) has led to an increased demand for alternative amphetamine-like drugs such as the synthetic cathinone, 4-methylmethcathinone (mephedrone). Despite the re-classification of mephedrone as a Class B restricted substance by the United Kingdom and restrictive legislation by the United States, international policy regarding mephedrone control is still developing and interest in synthetic amphetamine-like drugs could drive the development of future mephedrone analogues. Currently, there is little literature investigating the mechanism of action and long-term effects of mephedrone. As such, we reviewed the current understanding of amphetamines, cathinones, and cocaine emphasizing the potentially translational aspects to mephedrone, as well as contrasting with the work that has been done specifically on mephedrone in order to present the current state of understanding of mephedrone in terms of its risks, mechanisms, and behavioral effects. Emerging research suggests that while there are structural and behavioral similarities of mephedrone with amphetamine-like compounds, it appears that serotonergic signaling may mediate more of mephedrone's effects unlike the more dopaminergic dependent effects observed in traditional amphetamine-like compounds. As new designer drugs are produced, current and continuing research on mephedrone and other synthetic cathinones should help inform policymakers' decisions regarding the regulation of novel 'legal highs.'

  11. 43 CFR 46.115 - Consideration of past actions in the analysis of cumulative effects.

    Science.gov (United States)

    2010-10-01

    ... 43 Public Lands: Interior 1 2010-10-01 2010-10-01 false Consideration of past actions in the... Environmental Quality § 46.115 Consideration of past actions in the analysis of cumulative effects. When... Memorandum on Consideration of Past Actions in Cumulative Effects Analysis” dated June 24, 2005, or...

  12. Actions for adoption of effective dose equivalent standards

    International Nuclear Information System (INIS)

    Regulations related with radiological protection have been revised to adopt SI units and to accept the ICRP recommendation requesting to use the effective dose equivalent for radiation exposure control. The present report mainly deals with actions to be taken in the field of radiation instrumentation to promote the adoption of effective dose equivalent standards. In the past, exposure in roentgen has been generally used as a quantity to represent the intensity of a X-ray or alpha-ray field, because it can be measured relatively easily and accurately. The introduction of the effective dose equivalent is intended to establish annual exposure limits to ensure that the possibility of death of workers in a radioactive environment and that of development of hereditary disorders in their children or grandchildren will be maintained below permissible levels. The quantity is expressed as the sum of each organ's dose equivalent multiplied by a weight that reflects risks. Presently, such weights are assigned to seven organs including the gential glands and red marrow. Fixed-type area monitors and portable survey meters are used for work environment monitoring while film badges, TLDs, dosimeters, etc., are employed for personnel monitoring. (Nogami, K.)

  13. Ecological effects of contaminants and remedial actions in Bear Creek

    Energy Technology Data Exchange (ETDEWEB)

    Southworth, G.R.; Loar, J.M.; Ryon, M.G.; Smith, J.G.; Stewart, A.J. (Oak Ridge National Lab., TN (United States)); Burris, J.A. (C. E. Environmental, Inc., Tallahassee, FL (United States))

    1992-01-01

    Ecological studies of the Bear Creek watershed, which drains the area surrounding several Oak Ridge Y-12 Plant waste disposal facilities, were initiated in May 1984 and are continuing at present. These studies consisted of an initial, detailed characterization of the benthic invertebrate and fish communities in Bear Creek, and they were followed by a presently ongoing monitoring phase that involves reduced sampling intensities. The characterization phase utilized two approaches: (1) instream sampling of benthic invertebrate and fish communities in Bear Creek to identify spatial and temporal patterns in distribution and abundance and (2) laboratory bioassays on water samples from Bear Creek and selected tributaries to identify potential sources of toxicity to biota. The monitoring phase of the ecological program relates to the long-term goals of identifying and prioritizing contaminant sources and assessing the effectiveness of remedial actions. It continues activities of the characterization phase at less frequent intervals. The Bear Greek Valley is a watershed that drains the area surrounding several closed Oak Ridge Y-12 Plant waste disposal facilities. Past waste disposal practices in Bear Creek Valley resulted in contamination of Bear Creek and consequent ecological damage. Extensive remedial actions have been proposed at waste sites, and some of the have been implemented or are now underway. The proposed study plan consists of an initial, detailed characterization of the benthic invertebrate and fish communities in Bear Creek in the first year followed by a reduction in sampling intensity during the monitoring phase of the plan. The results of sampling conducted from May 1984 through early 1989 are presented in this report.

  14. Scales, strategies and actions for effective energy planning: A review

    International Nuclear Information System (INIS)

    This paper is a review of the most recent literature on the interaction between climate change, land-use and energy, based on the analysis of papers collected through the most relevant scientific literature databases. A total of 114 papers published between 2000 and 2011 were reviewed. The aims of this review are: in general (1) to identify the different research topics that have been developed related to the interaction between climate change, land-use and energy; more specifically, (2) to analyze what are the most suitable spatial and temporal scales of investigation to focus on for actions and strategies to reduce critical issues in the field of energy and environment; (3) to identify which actions and strategies are deemed as the most appropriate to mitigate critical issues in energy and environment; and given the research gaps found in the review, (4) to propose research recommendations in the context of effective climate-energy planning. We argue that there are certain gaps and needs for a “nested” environmental governance. It is necessary to understand how different environmental policies overlap and how they can be integrated in order to verify whether there are conflicting targets that may negate each other in the long term. - Highlights: • Energy production and consumption can directly or indirectly affect climate change. • Energy sector is influenced directly and indirectly by changes in climate conditions. • Energy sector and climate change affect and limit alternative uses of land, causing land-use changes. • The most suitable spatial scale for energy planning is the municipal level requiring short-term perspectives. • Several research recommendations to deal with the complexity of energy-land-use-climate change issue are proposed

  15. Ecological effects of contaminants and remedial actions in Bear Creek

    International Nuclear Information System (INIS)

    Ecological studies of the Bear Creek watershed, which drains the area surrounding several Oak Ridge Y-12 Plant waste disposal facilities, were initiated in May 1984 and are continuing at present. These studies consisted of an initial, detailed characterization of the benthic invertebrate and fish communities in Bear Creek, and they were followed by a presently ongoing monitoring phase that involves reduced sampling intensities. The characterization phase utilized two approaches: (1) instream sampling of benthic invertebrate and fish communities in Bear Creek to identify spatial and temporal patterns in distribution and abundance and (2) laboratory bioassays on water samples from Bear Creek and selected tributaries to identify potential sources of toxicity to biota. The monitoring phase of the ecological program relates to the long-term goals of identifying and prioritizing contaminant sources and assessing the effectiveness of remedial actions. It continues activities of the characterization phase at less frequent intervals. The Bear Greek Valley is a watershed that drains the area surrounding several closed Oak Ridge Y-12 Plant waste disposal facilities. Past waste disposal practices in Bear Creek Valley resulted in contamination of Bear Creek and consequent ecological damage. Extensive remedial actions have been proposed at waste sites, and some of the have been implemented or are now underway. The proposed study plan consists of an initial, detailed characterization of the benthic invertebrate and fish communities in Bear Creek in the first year followed by a reduction in sampling intensity during the monitoring phase of the plan. The results of sampling conducted from May 1984 through early 1989 are presented in this report

  16. The Geometry of Quantum Hall Effect: An Effective Action for all Dimensions

    OpenAIRE

    Karabali, Dimitra; Nair, V. P.

    2016-01-01

    We present a general formula for the topological part of the effective action for quantum Hall systems in higher dimensions, including fluctuations of the gauge field and metric around background fields of a specified topological class. The result is based on a procedure of integrating up from the Dolbeault index density which applies for the degeneracies of Landau levels, combined with some input from the standard descent procedure for anomalies. Features of the topological action in (2+1), ...

  17. Effects and Mechanism of Action of a Tribulus terrestris Extract on Penile Erection

    OpenAIRE

    Do, Jungmo; Choi, Seemin; Choi, Jaehwi; Hyun, Jae Seog

    2013-01-01

    Purpose Tribulus terrestris has been used as an aphrodisiac. However, little is known about the effects and mechanism of action of T. terrestris on penile erection. Therefore, the effect of a T. terrestris extract and the mechanism of action of the extract on relaxation of the corpus cavernosum (CC) were investigated. The erectogenic effects of an oral preparation of the extract were also assessed. Materials and Methods The relaxation effects and mechanism of action of the T. terrestris extra...

  18. Effects of action video game training on visual working memory.

    Science.gov (United States)

    Blacker, Kara J; Curby, Kim M; Klobusicky, Elizabeth; Chein, Jason M

    2014-10-01

    The ability to hold visual information in mind over a brief delay is critical for acquiring information and navigating a complex visual world. Despite the ubiquitous nature of visual working memory (VWM) in our everyday lives, this system is fundamentally limited in capacity. Therefore, the potential to improve VWM through training is a growing area of research. An emerging body of literature suggests that extensive experience playing action video games yields a myriad of perceptual and attentional benefits. Several lines of converging work suggest that action video game play may influence VWM as well. The current study utilized a training paradigm to examine whether action video games cause improvements to the quantity and/or the quality of information stored in VWM. The results suggest that VWM capacity, as measured by a change detection task, is increased after action video game training, as compared with training on a control game, and that some improvement to VWM precision occurs with action game training as well. However, these findings do not appear to extend to a complex span measure of VWM, which is often thought to tap into higher-order executive skills. The VWM improvements seen in individuals trained on an action video game cannot be accounted for by differences in motivation or engagement, differential expectations, or baseline differences in demographics as compared with the control group used. In sum, action video game training represents a potentially unique and engaging platform by which this severely capacity-limited VWM system might be enhanced. PMID:25068696

  19. Effects of action video game training on visual working memory.

    Science.gov (United States)

    Blacker, Kara J; Curby, Kim M; Klobusicky, Elizabeth; Chein, Jason M

    2014-10-01

    The ability to hold visual information in mind over a brief delay is critical for acquiring information and navigating a complex visual world. Despite the ubiquitous nature of visual working memory (VWM) in our everyday lives, this system is fundamentally limited in capacity. Therefore, the potential to improve VWM through training is a growing area of research. An emerging body of literature suggests that extensive experience playing action video games yields a myriad of perceptual and attentional benefits. Several lines of converging work suggest that action video game play may influence VWM as well. The current study utilized a training paradigm to examine whether action video games cause improvements to the quantity and/or the quality of information stored in VWM. The results suggest that VWM capacity, as measured by a change detection task, is increased after action video game training, as compared with training on a control game, and that some improvement to VWM precision occurs with action game training as well. However, these findings do not appear to extend to a complex span measure of VWM, which is often thought to tap into higher-order executive skills. The VWM improvements seen in individuals trained on an action video game cannot be accounted for by differences in motivation or engagement, differential expectations, or baseline differences in demographics as compared with the control group used. In sum, action video game training represents a potentially unique and engaging platform by which this severely capacity-limited VWM system might be enhanced.

  20. Regulation of international energy markets: Economic effects of political actions

    Science.gov (United States)

    Shcherbakova, Anastasia V.

    Recent increases in volatility of energy prices have led many governments to reevaluate their regard of national energy reserves and reconsider future exploration, production, and consumption patterns. The flurry of activity that has been generated by such price volatility has included large-scale nationalizations of energy sectors, unilateral renegotiations of foreign energy development contracts, and expropriations of resources from foreign energy firms on one hand, and on the other hand more rapid energy sector liberalization, intensified search for and development of renewable fuels and technologies, and development of incentives for increased energy efficiency and conservation. The aim of this dissertation is to examine and quantify the extent of positive and negative effects that have resulted from some of these activities. The first chapter focuses on quantifying the effect that nationalistic sentiment has had on economic attractiveness of energy sectors during the decade prior to the recent global economic crisis, as measured by foreign direct investment (FDI) inflows. Empirical results demonstrate that both political and economic conditions play an important role in investors' decisions. A combination of investment friendliness, corruption levels, and democracy all help to explain the trends in energy-sector investment levels over time in my sample countries, although differences in the types of corruption existing in these nations do not. Investment levels, in turn, appear to influence future levels of oil production, underscoring the significance of good investment policies for future success of energy sectors. Chapter two considers the response of energy stock prices to severe regulatory actions. It employs an event study framework to examine causal effects of critical informational announcements (i.e. events of expropriation and nationalization) on daily returns and cumulative losses in firm value of energy corporations. Results show that a firm

  1. Polyphenols: Extraction Methods, Antioxidative Action, Bioavailability and Anticarcinogenic Effects.

    Science.gov (United States)

    Brglez Mojzer, Eva; Knez Hrnčič, Maša; Škerget, Mojca; Knez, Željko; Bren, Urban

    2016-01-01

    Being secondary plant metabolites, polyphenols represent a large and diverse group of substances abundantly present in a majority of fruits, herbs and vegetables. The current contribution is focused on their bioavailability, antioxidative and anticarcinogenic properties. An overview of extraction methods is also given, with supercritical fluid extraction highlighted as a promising eco-friendly alternative providing exceptional separation and protection from degradation of unstable polyphenols. The protective role of polyphenols against reactive oxygen and nitrogen species, UV light, plant pathogens, parasites and predators results in several beneficial biological activities giving rise to prophylaxis or possibly even to a cure for several prevailing human diseases, especially various cancer types. Omnipresence, specificity of the response and the absence of or low toxicity are crucial advantages of polyphenols as anticancer agents. The main problem represents their low bioavailability and rapid metabolism. One of the promising solutions lies in nanoformulation of polyphenols that prevents their degradation and thus enables significantly higher concentrations to reach the target cells. Another, more practiced, solution is the use of mixtures of various polyphenols that bring synergistic effects, resulting in lowering of the required therapeutic dose and in multitargeted action. The combination of polyphenols with existing drugs and therapies also shows promising results and significantly reduces their toxicity. PMID:27409600

  2. Polyphenols: Extraction Methods, Antioxidative Action, Bioavailability and Anticarcinogenic Effects

    Directory of Open Access Journals (Sweden)

    Eva Brglez Mojzer

    2016-07-01

    Full Text Available Being secondary plant metabolites, polyphenols represent a large and diverse group of substances abundantly present in a majority of fruits, herbs and vegetables. The current contribution is focused on their bioavailability, antioxidative and anticarcinogenic properties. An overview of extraction methods is also given, with supercritical fluid extraction highlighted as a promising eco-friendly alternative providing exceptional separation and protection from degradation of unstable polyphenols. The protective role of polyphenols against reactive oxygen and nitrogen species, UV light, plant pathogens, parasites and predators results in several beneficial biological activities giving rise to prophylaxis or possibly even to a cure for several prevailing human diseases, especially various cancer types. Omnipresence, specificity of the response and the absence of or low toxicity are crucial advantages of polyphenols as anticancer agents. The main problem represents their low bioavailability and rapid metabolism. One of the promising solutions lies in nanoformulation of polyphenols that prevents their degradation and thus enables significantly higher concentrations to reach the target cells. Another, more practiced, solution is the use of mixtures of various polyphenols that bring synergistic effects, resulting in lowering of the required therapeutic dose and in multitargeted action. The combination of polyphenols with existing drugs and therapies also shows promising results and significantly reduces their toxicity.

  3. Effect of Composite Action on the Strength of Wood Roofs

    Directory of Open Access Journals (Sweden)

    Ivan A. Campos Varela

    2015-01-01

    Full Text Available Engineering certification for the installation of solar photovoltaic modules on wood roofs is often denied because existing wood roofs do not meet current building codes. Rather than requiring expensive structural retrofits, we desire to show that many roofs are actually sufficiently strong if the effect of composite action produced by joist-sheathing interaction is considered. In a series of laboratory experiments using a limited number of two-by-four wood joists with and without sheathing panels, conventionally sheathed stud-grade joists, surprisingly, exhibited between 18% and 63% higher nominal strength than similar bare joists. To explain this strength increase, a simple model was developed to predict the strengths of the nailed partially composite sections, but the model only justifies a 1.4% to 3.8% increase in bending strength of joists with an allowable bending strength of 1000 psi. More testing is indicated to resolve this discrepancy between laboratory results and analytical modeling results. In addition to elucidating nonlinear partial composite behavior of existing roof systems, this paper shows that, with minor changes in roof framing practices, strength increases of 70% or more are achievable, compared to the strengths of conventionally sheathed joists.

  4. Fine tuning and vacuum stability in Wilsonian effective action

    CERN Document Server

    Krajewski, Tomasz

    2014-01-01

    We have computed Wilsonian effective action in a simple model containing scalar field with quartic self-coupling which interacts via Yukawa coupling with a Dirac fermion. The model is invariant under a chiral parity operation, which can be spontaneously broken by a vev of the scalar field. We have computed explicitly Wilsonian running of relevant parameters which makes it possible to discuss in a consistent manner the issue of fine-tuning and stability of the scalar potential. This has been compared with the typical picture based on Gell-Mann-Low running. Since Wilsonian running includes automatically integration out of heavy degrees of freedom, the running differs markedly from the Gell-Mann-Low version. However, similar behaviour can be observed: scalar mass squared parameter and the quartic coupling can change sign from a positive to a negative one due to running which causes spontaneous symmetry breaking or an instability in the renormalizable part of the potential for a given range of scales. However, ca...

  5. On compatibility of string effective action with an accelerating universe

    Energy Technology Data Exchange (ETDEWEB)

    Neupane, Ishwaree P [Department of Physics and Astronomy, University of Canterbury, Private Bag 4800, Christchurch (New Zealand); Central Department of Physics, Tribhuvan University, Kirtipur, Kathmandu (Nepal)

    2006-12-21

    In this paper, we fully investigate the cosmological effects of the moduli-dependent one-loop corrections to the gravitational couplings of the string effective action to explain the cosmic acceleration problem in the early (and/or late) universe. These corrections comprise a Gauss-Bonnet (GB) invariant multiplied by universal non-trivial functions of the common modulus {sigma} and the dilaton {phi}. The model exhibits several features of cosmological interest, including the transition between deceleration and acceleration phases. By considering some phenomenologically motivated ansatze for one of the scalars and/or the scale factor (of the universe), we also construct a number of interesting inflationary potentials. In all examples under consideration, we find that the model leads only to a standard inflation (w {>=} -1) when the numerical coefficient {delta} associated with modulus-GB coupling is positive, while the model can also lead to a non-standard inflation (w < -1), if {delta} is negative. In the absence of (or trivial) coupling between the GB term and the scalars, there is no crossing between the w < -1 and w > -1 phases, while this is possible with non-trivial GB couplings, even for the constant dilaton phase of the standard picture. Within our model, after a sufficient amount of e-folds of expansion, the rolling of both fields {phi} and {sigma} can be small. In turn, any possible violation of equivalence principle or deviations from the standard general relativity may be small enough to easily satisfy all astrophysical and cosmological constraints.

  6. Experts see it all: configural effects in action observation

    OpenAIRE

    Calvo-Merino, B.; Ehrenberg, S; Leung, D. M. H.; Haggard, P

    2010-01-01

    Biological motion perception is influenced by observers’ familiarity with the observed action. Here we used classical dance as a means to investigate how visual and motor experience modulates perceptual mechanism for configural processing of actions. While some ballet moves are performed by only one gender, male and female dancers train together and acquire visual knowledge of all ballet moves. 24 expert ballet dancers (12 female) and matched non-expert participants viewed pairs of upright an...

  7. Renormalization-group flow of the effective action of cosmological large-scale structures

    OpenAIRE

    Floerchinger, Stefan; Garny, Mathias; Tetradis, Nikolaos; Wiedemann, Urs Achim

    2016-01-01

    Following an approach of Matarrese and Pietroni, we derive the functional renormalization group (RG) flow of the effective action of cosmological large-scale structures. Perturbative solutions of this RG flow equation are shown to be consistent with standard cosmological perturbation theory. Non-perturbative approximate solutions can be obtained by truncating the a priori infinite set of possible effective actions to a finite subspace. Using for the truncated effective action a form dictated ...

  8. The effects of an action video game on visual and affective information processing.

    Science.gov (United States)

    Bailey, Kira; West, Robert

    2013-04-01

    Playing action video games can have beneficial effects on visuospatial cognition and negative effects on social information processing. However, these two effects have not been demonstrated in the same individuals in a single study. The current study used event-related brain potentials (ERPs) to examine the effects of playing an action or non-action video game on the processing of emotion in facial expression. The data revealed that 10h of playing an action or non-action video game had differential effects on the ERPs relative to a no-contact control group. Playing an action game resulted in two effects: one that reflected an increase in the amplitude of the ERPs following training over the right frontal and posterior regions that was similar for angry, happy, and neutral faces; and one that reflected a reduction in the allocation of attention to happy faces. In contrast, playing a non-action game resulted in changes in slow wave activity over the central-parietal and frontal regions that were greater for targets (i.e., angry and happy faces) than for non-targets (i.e., neutral faces). These data demonstrate that the contrasting effects of action video games on visuospatial and emotion processing occur in the same individuals following the same level of gaming experience. This observation leads to the suggestion that caution should be exercised when using action video games to modify visual processing, as this experience could also have unintended effects on emotion processing.

  9. Effective actions for F-theory compactifications and tensor theories

    International Nuclear Information System (INIS)

    In this thesis we study the low-energy effective dynamics emerging from a class of F-theory compactifications in four and six dimensions. We also investigate six-dimensional supersymmetric quantum field theories with self-dual tensors, motivated by the problem of describing the long-wavelength regime of a stack of M5-branes in M-theory. These setups share interesting common features. They both constitute examples of intrinsically non-perturbative physics. On the one hand, in the context of F-theory the non-perturbative character is encoded in the geometric formulation of this class of string vacua, which allows the complexified string coupling to vary in space. On the other hand, the dynamics of a stack of multiple M5-branes flows in the infrared to a novel kind of superconformal field theories in six dimensions - commonly referred to as (2,0) theories - that are expected to possess no perturbative weakly coupled regime and have resisted a complete understanding so far. In particular, no Lagrangian description is known for these models. The strategy we employ to address these two problems is also analogous. A recurring Leitmotif of our work is a transdimensional treatment of the system under examination: in order to extract information about dynamics in d dimensions we consider a (d-1)-dimensional setup. As far as F-theory compactifications are concerned, this is a consequence of the duality between M-theory and F-theory, which constitutes our main tool in the derivation of the effective action of F-theory compactifications. We apply it to six-dimensional F-theory vacua, obtained by taking the internal space to be an elliptically fibered Calabi-Yau threefold, but we also employ it to explore a novel kind of F-theory constructions in four dimensions based on manifolds with Spin(7) holonomy. With reference to six-dimensional (2,0) theories, the transdimensional character of our approach relies in the idea of studying these theories in five dimensions. Indeed, we

  10. Effects of navigated TMS on object and action naming

    Directory of Open Access Journals (Sweden)

    Julio Cesar Hernandez-Pavon

    2014-09-01

    Full Text Available Transcranial magnetic stimulation (TMS has been used to induce speech disturbances and to affect speech performance during different naming tasks. Lately, repetitive navigated TMS (nTMS has been used for non-invasive mapping of cortical speech-related areas. Different naming tasks may give different information that can be useful for presurgical evaluation. We studied the sensitivity of object and action naming tasks to nTMS and compared the distributions of cortical sites where nTMS produced naming errors. Eight healthy subjects named pictures of objects and actions during repetitive nTMS delivered to semi-random left-hemispheric sites. Subject-validated image stacks were obtained in the baseline naming of all pictures before nTMS. Thereafter, nTMS pulse trains were delivered while the subjects were naming the images of objects or actions. The sessions were video-recorded for offline analysis. Naming during nTMS was compared with the baseline performance. The nTMS-induced naming errors were categorized by error type and location. nTMS produced no-response errors, phonological paraphasias, and semantic paraphasias. In seven out of eight subjects, nTMS produced more errors during object than action naming. Both intrasubject and intersubject analysis showed that object naming was significantly more sensitive to nTMS. When the number of errors was compared according to a given area, nTMS to postcentral gyrus induced more errors during object than action naming. Object naming is apparently more easily disrupted by TMS than action naming. Different stimulus types can be useful for locating different aspects of speech functions. This provides new possibilities in both basic and clinical research of cortical speech representations.

  11. Geometry of the quantum Hall effect: An effective action for all dimensions

    Science.gov (United States)

    Karabali, Dimitra; Nair, V. P.

    2016-07-01

    We present a general formula for the topological part of the effective action for integer quantum Hall systems in higher dimensions, including fluctuations of the gauge field and metric around background fields of a specified topological class. The result is based on a procedure of integrating up from the Dolbeault index density which applies for the degeneracies of Landau levels, combined with some input from the standard descent procedure for anomalies. Features of the topological action in (2 +1 ), (4 +1 ), (6 +1 ) dimensions, including the contribution due to gravitational anomalies, are discussed in some detail.

  12. The Geometry of Quantum Hall Effect: An Effective Action for all Dimensions

    CERN Document Server

    Karabali, Dimitra

    2016-01-01

    We present a general formula for the topological part of the effective action for quantum Hall systems in higher dimensions, including fluctuations of the gauge field and metric around background fields of a specified topological class. The result is based on a procedure of integrating up from the Dolbeault index density which applies for the degeneracies of Landau levels, combined with some input from the standard descent procedure for anomalies. Features of the topological action in (2+1), (4+1), (6+1) dimensions, including the contribution due to gravitational anomalies, are discussed in some detail.

  13. Effects of context on visuomotor interference depends on the perspective of observed actions.

    Directory of Open Access Journals (Sweden)

    Marta Bortoletto

    Full Text Available Visuomotor interference occurs when the execution of an action is facilitated by the concurrent observation of the same action and hindered by the concurrent observation of a different action. There is evidence that visuomotor interference can be modulated top-down by higher cognitive functions, depending on whether own performed actions or observed actions are selectively attended. Here, we studied whether these effects of cognitive context on visuomotor interference are also dependent on the point-of-view of the observed action. We employed a delayed go/no-go task known to induce visuomotor interference. Static images of hand gestures in either egocentric or allocentric perspective were presented as "go" stimuli after participants were pre-cued to prepare either a matching (congruent or non-matching (incongruent action. Participants performed this task in two different cognitive contexts: In one, they focused on the visual image of the hand gesture shown as the go stimulus (image context, whereas in the other they focused on the hand gesture they performed (action context. We analyzed reaction times to initiate the prepared action upon presentation of the gesture image and found evidence of visuomotor interference in both contexts and for both perspectives. Strikingly, results show that the effect of cognitive context on visuomotor interference also depends on the perspective of observed actions. When focusing on own-actions, visuomotor interference was significantly less for gesture images in allocentric perspective than in egocentric perspective; when focusing on observed actions, visuomotor interference was present regardless of the perspective of the gesture image. Overall these data suggest that visuomotor interference may be modulated by higher cognitive processes, so that when we are specifically attending to our own actions, images depicting others' actions (allocentric perspective have much less interference on our own actions.

  14. 10D massive type IIA supergravities as the uplift of parabolic M2-brane torus bundles

    Energy Technology Data Exchange (ETDEWEB)

    Garcia del Moral, Maria Pilar [Universidad de Antofagasta (Chile). Dept. de Fisica; Restuccia, Alvaro [Universidad de Antofagasta (Chile). Dept. de Fisica; Universidad Simon Bolivar, Caracas (Venezuela, Bolivarian Republic of). Dept. de Fisica

    2016-04-15

    We remark that the two 10D massive deformations of the N = 2 maximal type IIA supergravity (Romans and HLW supergravity) are associated to the low energy limit of the uplift to 10D of M2-brane torus bundles with parabolic monodromy linearly and non-linearly realized respectively. Romans supergravity corresponds to M2-brane compactified on a twice-punctured torus bundle. (copyright 2015 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

  15. Comment on ``Functional integral for Weyl fermions and the effective action''

    Science.gov (United States)

    Banerjee, R.; Banerjee, H.

    1989-02-01

    Baaklini's method of obtaining the effective action for Weyl fermions is shown to yield either a gauge-invariant or a gauge-variant form depending on the specific definition employed in the analysis. The structures of the effective action proposed by Baaklini are found to correspond to the standard expressions.

  16. 2PI Effective Action and Evolution Equations of N = 4 super Yang-Mills

    CERN Document Server

    Smolic, Jelena

    2011-01-01

    We employ nPI effective action techniques to study N = 4 super Yang-Mills, and write down the 2PI effective action of the theory. We also supply the evolution equations of two-point correlators within the theory.

  17. Conformally covariant operators and the effective action in an external gravitational field

    International Nuclear Information System (INIS)

    The n-dimensional expressions for the second-order conformally covariant differential operators acting on vector and tensor fields and for the fourth-order conformally covariant operator acting on scalar fields are obtained. For the fourth-order operator one-loop effective action is evaluated in four dimensions. The possibility of effective action evaluation for other conformally covariant operators is discussed

  18. On the effective character of a non abelian DBI action

    CERN Document Server

    Osorio, M A R; Suárez, María

    2001-01-01

    We study the way Lorentz covariance can be reconstructed from Matrix Theory as a IMF description of M-theory. The problem is actually related to the interplay between a non abelian Dirac-Born-Infeld action and Super-Yang-Mills as its generalized non-relativistic approximation. All this physics shows up by means of an analysis of the asymptotic expansion of the Bessel functions $K_\

  19. Action semantics modulate action prediction.

    Science.gov (United States)

    Springer, Anne; Prinz, Wolfgang

    2010-11-01

    Previous studies have demonstrated that action prediction involves an internal action simulation that runs time-locked to the real action. The present study replicates and extends these findings by indicating a real-time simulation process (Graf et al., 2007), which can be differentiated from a similarity-based evaluation of internal action representations. Moreover, results showed that action semantics modulate action prediction accuracy. The semantic effect was specified by the processing of action verbs and concrete nouns (Experiment 1) and, more specifically, by the dynamics described by action verbs (Experiment 2) and the speed described by the verbs (e.g., "to catch" vs. "to grasp" vs. "to stretch"; Experiment 3). These results propose a linkage between action simulation and action semantics as two yet unrelated domains, a view that coincides with a recent notion of a close link between motor processes and the understanding of action language.

  20. More evidence for a refined Gribov-Zwanziger action based on an effective potential approach

    OpenAIRE

    Vandersickel, N.; Dudal, D.; Sorella, S.P.

    2011-01-01

    The purpose of this proceeding is twofold. Firstly, we shall make the refining of the Gribov-Zwanziger action more complete by taking into account more condensates than considered so far. Secondly, we shall provide more evidence for the refined Gribov-Zwanziger action based on an effective potential approach.

  1. In-Out Formalism for One-Loop Effective Actions in QED and Gravity

    CERN Document Server

    Kim, Sang Pyo

    2016-01-01

    The in-out formalism is a systematic and powerful method for finding the effective actions in an electromagnetic field and a curved spacetime provided that the field equation has explicitly known solutions. The effective action becomes complex when pairs of charged particles are produced due to an electric field and curved spacetime. This may lead to a conjecture of one-to-one correspondence between the vacuum polarization (real part) and the vacuum persistence (imaginary part). We illustrate the one-loop effective action in a constant electric field in a Minkowski spacetime and in a uniform electric field in a two-dimensional (anti-) de sitter space.

  2. System markets: Indirect network effects in action, or inaction?

    NARCIS (Netherlands)

    J.L.G. Binken (Jeroen)

    2010-01-01

    textabstractIn this dissertation, I empirically examine system markets up close. More specifically I examine indirect network effects, both demand-side and supply-side indirect network effects. Indirect network effects are the source of positive feedback in system markets, or so network effect theo

  3. Effect of a prenylamine analog (MG8926) on spontaneous action potentials in isolated rabbit sinoatrial node.

    Science.gov (United States)

    Nakanishi, H; Matsuoka, I; Ono, T; Yoshida, H; Uchibori, T; Kogi, K

    1996-12-01

    Effects of verapamil, prenylamine and a prenylamine analog, MG8926 on the intracellular spontaneous action potentials recorded from the isolated rabbit sinoatrial (SA) node were studied. Verapamil (1 microM), a selective inhibitor for slow Ca2+ channels, prolonged the cycle length, decreased the rate of diastolic depolarization, the rate of rise of action potential, the amplitude of action potential and the maximal diastolic potential, and usually arrested showing subthreshold fluctuation of the membrane potential within several ten min. Prenylamine (10 microM), a nonselective inhibitor for slow Ca2+ channels, tended to prolong the cycle length to decrease the diastolic depolarization, the rate of rise of action potential, the amplitude of action potential. However, these changes were statistically insignificant. Prenylamine at the concentration of 10 microM had no effect on the maximal diastolic potential. MG8926 (10 microM) prolonged the cycle length, decreased the rate of diastolic depolarization, the rate of rise of action potential and tended to decrease the amplitude of action potential. MG8926 at the concentration of 10 microM had almost no effect on the maximal diastolic potential. The present findings may indicate that replacement of phenyl residue of prenylamine by cyclohexyl residue increases the inhibitory action on the slow Ca2+ channels in rabbit SA node.

  4. Effective actions for the SU(2) confinement-deconfinement phase transition

    International Nuclear Information System (INIS)

    We compare different Polyakov-loop actions yielding effective descriptions of finite-temperature SU(2) Yang-Mills theory on the lattice. The actions are motivated by a simultaneous strong coupling and character expansion obeying center symmetry and include both Ising and Ginzburg-Landau type models. To keep things simple we limit ourselves to nearest-neighbor interactions. Some truncations involving the most relevant characters are studied within a novel mean-field approximation. Using inverse Monte Carlo techniques based on exact geometrical Schwinger-Dyson equations we determine the effective couplings of the Polyakov-loop actions. Monte Carlo simulations of these actions reveal that the mean-field analysis is a fairly good guide to the physics involved. Our Polyakov-loop actions reproduce standard Yang-Mills observables well up to limitations due to the nearest-neighbor approximation

  5. Action time effect of lime on its depressive ability for pyrite

    Institute of Scientific and Technical Information of China (English)

    Tichang Sun

    2004-01-01

    Two sample groups of bulk concentrates consisting mainly of pyrite and chalcopyrite from Daye and Chenghchao Mines in Hubei Province of China were used to investigate the effect of the action time of lime on its depressive ability for pyrite. The experimental results conducted with different samples and collectors showed that the action time between lime and pyrite markedly influences the depressive ability of lime. The depressive ability of lime increased with the action time increasing. It was also proved that the depressive results obtained at a large lime dosage after a shorter action time are similar to those obtained at a small lime dosage after a longer action time. The increase of depressive ability of lime after a longer action time is because that there are different mechanisms in different action time. The composition on the surface of pyrite acted for different time with lime was studied by using ESCA (Electron Spectroscopic Chemical Analysis). The results showed that iron hydroxide and calcium sulphate formed on the pyrite surface at the presence of lime in the pulp but the amounts of iron hydroxide and calcium sulphate were different at different action time. At the beginning action time the compound formed on the pyrite surface was mainly calcium sulphate and almost no iron hydroxide formed; but with the action time increasing, iron hydroxide formed. The longer the action time, the more iron hydroxide and the less calcium sulphate formed. It was considered that the stronger depressive ability of lime after a longer action time is because more iron hydroxide forms on the pyrite surface.

  6. System markets: Indirect network effects in action, or inaction?

    OpenAIRE

    Binken, Jeroen

    2010-01-01

    textabstractIn this dissertation, I empirically examine system markets up close. More specifically I examine indirect network effects, both demand-side and supply-side indirect network effects. Indirect network effects are the source of positive feedback in system markets, or so network effect theory tells us. Systems are composed of complementary and interdependent products, such as hardware and software. For instance, a video game system is composed of the video game console, on the one han...

  7. Leadership: Improving Its Effectiveness. Research Action Brief Number 1.

    Science.gov (United States)

    ERIC Clearinghouse on Educational Management, Eugene, OR.

    This brief summarizes the major findings of significant research studies dealing with different leadership behaviors and strategies for increasing leadership effectiveness. Fred Fiedler's Contingency Theory of Leadership Effectiveness emphasizes that a leader's effectiveness is determined by how well his leadership style fits the specific…

  8. Characteristics of Effective Training: Developing a Model To Motivate Action.

    Science.gov (United States)

    Wise, Dena; Ezell, Patsy

    2003-01-01

    The Parenting and Consumer Education project identified effective models for training welfare-to-work facilitators. Premises were the importance of process, learner responsibility, and improvement of social networks. Effective training was learner focused, inspiring, and motivating; demonstrated productive behaviors and effective life skills; and…

  9. Fight against the greenhouse effect. From the local to the international action

    International Nuclear Information System (INIS)

    In the fight against the greenhouse gases emissions, the local government are directly concerned. This sheet aims to explain the greenhouse effect, the kyoto protocol, the french national policy and to orientate the local actions. (A.L.B.)

  10. The generalized Schwinger-DeWitt technique and the unique effective action in quantum gravity

    International Nuclear Information System (INIS)

    The purpose of this talk is to discuss how one can define and compute the effective action. The authors consider the following subjects: 1. The parameterization-independent and gauge-independent definition of the effective action in QFT. 2. Extension of the Schwinger-DeWitt technique to nonminimal operators, higher-order operators and higher loop orders. The method of generating functional traces. 3. Summation of the proper-time series. Nonlocal terms in the effective action. 4. Applications. The complete algorithm for divergences of a fourth-order operator. The calculational technique for the unique effective action in gauge theories. The unique counterterms for Einstein's theory. Covariant calculation of divergences in two-loop graphs and the absence of leading divergences in two-loop quantum gravity

  11. T-duality in the string theory effective action with a string source

    OpenAIRE

    Nurmagambetov, Alexei

    2001-01-01

    We consider the T-duality transformations of the low-energy quantum string theory effective action in the presence of classical fundamental string source and demonstrate explicitly that T-duality still holds.

  12. Mechanism and Effectiveness of Reduction Action of Unsaturated Polyester Resin Reducer

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    The reduction action mechanism of unsaturated polyester resin reducer is analysed.The experimental results show that the active reducer bearing reactive functional group on the ends of molecules effectively lowers the curing shrinkage of unvaturated polyester resin.

  13. The effects of familiarity on thought--action fusion.

    Science.gov (United States)

    Berman, Noah C; Wheaton, Michael G; Fabricant, Laura E; Jacobson, Spenser R; Abramowitz, Jonathan S

    2011-10-01

    The present study examined whether beliefs about the importance of thoughts (i.e., thought--action fusion; TAF) are related to the target subject of the negative thought. One hundred and seven undergraduate students were randomly assigned to imagine either a beloved relative or a stranger being diagnosed with cancer and provided in vivo ratings of anxiety, likelihood, moral wrongness, urge to neutralize, and how upsetting the event would be if it occurred. Results indicated that thinking of a relative being diagnosed with cancer provoked more distress, urges to neutralize, and higher estimates of likelihood, as well greater use of mental neutralizing behaviors, compared to thinking of a stranger. Contrary to our prediction, the groups did not differ in their ratings of the moral wrongness. These findings broadly support the assertion that the more personally significant a negative intrusive thought, the more it will provoke distress and urges to neutralize. Results are discussed in terms of the cognitive model of obsessions and clinical implications are addressed. PMID:21835394

  14. The Quantum Consistency of the Ten-Dimensional Heterotic String Effective Action

    Institute of Scientific and Technical Information of China (English)

    Simon Davis

    2011-01-01

    The finiteness of superstring theory at each order in perturbation theory is considered with respect to the ten-dimensional effective action. The quantum consistency of the ten-dimensional superstring effective action is confirmed with an analysis of the perturbative expansion of the quartic sector. It is found to be compatible with the finiteness of reduced four-dimensional theory. Furthermore, implications for the validity of superstring perturbation theory at lower energies is considered.

  15. 10D to 4D Euclidean Supergravity over a Calabi-Yau three-fold

    CERN Document Server

    Sabra, Wafic

    2015-01-01

    We dimensionally reduce the bosonic sector of 10D Euclidean type IIA supergravity over a Calabi-Yau three-fold. The resulting theory describes the bosonic sector of 4D, N = 2 Euclidean supergravity coupled to vector- and hyper-multiplets.

  16. RG flows in d dimensions, the dilaton effective action, and the a-theorem

    CERN Document Server

    Elvang, Henriette

    2012-01-01

    Motivated by the recent dilaton-based proof of the 4d a-theorem, we study the dilaton effective action for RG flows in d dimensions. When d is even, the action consists of a Wess-Zumino (WZ) term, whose Weyl-variation encodes the trace-anomaly, plus all Weyl-invariants. For d odd, the action consists of Weyl-invariants only. We present explicit results for the flat-space limit of the dilaton effective action in d-dimensions up to and including 8-derivative terms. GJMS-operators from conformal geometry motivate a form of the action that unifies the Weyl-invariants and anomaly-terms into a compact general-d structure. A new feature in 8d is the presence of an 8-derivative Weyl-invariant that pollutes the O(p^8)-contribution from the WZ action to the dilaton scattering amplitudes; this may challenge a dilaton-based proof of an a-theorem in 8d. We use the example of a free massive scalar for two purposes: 1) it allows us to confirm the structure of the d-dimensional dilaton effective action explicitly; we carry o...

  17. Buildup of the Kondo effect from real-time effective action for the Anderson impurity model

    Science.gov (United States)

    Bock, Sebastian; Liluashvili, Alexander; Gasenzer, Thomas

    2016-07-01

    The nonequilibrium time evolution of a quantum dot is studied by means of dynamic equations for time-dependent Green's functions derived from a two-particle-irreducible (2PI) effective action for the Anderson impurity model. Coupling the dot between two leads at different voltages, the dynamics of the current through the dot is investigated. We show that the 2PI approach is capable of describing the dynamical buildup of the Kondo effect, which shows up as a sharp resonance in the spectral function, with a width exponentially suppressed in the electron self-coupling on the dot. An external voltage applied to the dot is found to deteriorate the Kondo effect at the hybridization scale. The dynamic equations are evaluated within different nonperturbative resummation schemes, within the direct, particle-particle, and particle-hole channels, as well as their combination, and the results compared with those from other methods.

  18. On the Effective Action of Dressed Mean Fields for N = 4 Super-Yang-Mills Theory

    Directory of Open Access Journals (Sweden)

    Gorazd Cvetic

    2006-01-01

    Full Text Available On the basis of the general considerations such as R-operation and Slavnov-Taylor identity we show that the effective action, being understood as Legendre transform of the logarithm of the path integral, possesses particular structure in N = 4 supersymmetric Yang-Mills theory for kernels of the effective action expressed in terms of the dressed effective fields. These dressed effective fields have been introduced in our previous papers as actual variables of the effective action. The concept of dressed effective fields naturally appears in the framework of solution to Slavnov-Taylor identity. The particularity of the structure is independence of these kernels on the ultraviolet regularization scale Λ. These kernels are functions of mutual spacetime distances and of the gauge coupling. The fact that β function in this theory vanishes is used significantly.

  19. Renormalization-group flow of the effective action of cosmological large-scale structures

    CERN Document Server

    Floerchinger, Stefan; Tetradis, Nikolaos; Wiedemann, Urs Achim

    2016-01-01

    Following an approach of Matarrese and Pietroni, we derive the functional renormalization group (RG) flow of the effective action of cosmological large-scale structures. Perturbative solutions of this RG flow equation are shown to be consistent with standard cosmological perturbation theory. Non-perturbative approximate solutions can be obtained by truncating the a priori infinite set of possible effective actions to a finite subspace. Using for the truncated effective action a form dictated by dissipative fluid dynamics, we derive RG flow equations for the scale dependence of the effective viscosity and sound velocity of non-interacting dark matter, and we solve them numerically. Physically, the effective viscosity and sound velocity account for the interactions of long-wavelength fluctuations with the spectrum of smaller-scale perturbations. We find that the RG flow exhibits an attractor behaviour in the IR that significantly reduces the dependence of the effective viscosity and sound velocity on the input ...

  20. Conformal Invariance of the D-Particle Effective Action

    OpenAIRE

    Hayasaka, Kiyoshi; Nakayama, Ryuichi

    1999-01-01

    It is shown that the effective theory of D-particles has conformal symmetry with field-dependent parameters. This is a consequence of the supersymmetry. The string coupling constant is not transformed in contrast with the recent proposal of generalized conformal symmtery by Jevicki et al. This conformal symmetry can also be generalized to other Dp-brane systems.

  1. Observation Can Be as Effective as Action in Problem Solving

    Science.gov (United States)

    Osman, Magda

    2008-01-01

    This study discusses findings that replicate and extend the original work of Burns and Vollmeyer (2002), which showed that performance in problem-solving tasks was more accurate when people were engaged in a non-specific goal than in a specific goal. The main innovation here was to examine the goal specificity effect under both observation-based…

  2. Low-energy effective action in N = 2 supersymmetric field theories

    International Nuclear Information System (INIS)

    Review of new approach to finding effective action in N = 2 and N = 4 supersymmetric theory is given. The approach is based on the formulation of these theories in terms of unconstrained superfields in harmonic superspace. Construction of superfield model of N = 2 supersymmetric field theory (hypermultiplet, N = 2 supersymmetric Yang-Mills theory) is discussed. N = 2 background field method is considered. Perturbative holomorphic effective potential in N = 2 models and non-holomorphic effective potential in N = 4 Yang-Mills field theory, defining exact low-energy effective action in this theory, are studied. Possible applications of low-energy effective action in supersymmetric theories and some open problems are discussed. Comparison of given approach with others is performed

  3. Estimation of Several Political Action Effects of Energy Prices

    CERN Document Server

    Whitford, Andrew B

    2015-01-01

    One important effect of price shocks in the United States has been increased political attention paid to the structure and performance of oil and natural gas markets, along with some governmental support for energy conservation. This paper describes how price changes helped lead the emergence of a political agenda accompanied by several interventions, as revealed through Granger causality tests on change in the legislative agenda.

  4. The anomaly-induced effective action and natural inflation

    CERN Document Server

    Pelinson, A M; Solà, J; Takakura, F I

    2003-01-01

    The anomaly-induced inflation (modified Starobinsky model) is based on the application of the effective quantum field theory approach to the Early Universe. We present a brief general review of the model and show that it does not require a fine-tuning for the parameters of the theory or initial data, gives a real chance to meet a graceful exit to the FRW phase and also has positive features with respect to the metric perturbations.

  5. Technology and collective action: the effect of cell phone coverage on political violence in Africa

    OpenAIRE

    Pierskalla, Jan H.; Hollenbach, Florian M.

    2013-01-01

    The spread of cell phone technology across Africa has transforming effects on the economic and political sphere of the continent. In this paper, we investigate the impact of cell phone technology on violent collective action. We contend that the availability of cell phones as a communication technology allows political groups to overcome collective action problems more easily and improve in-group cooperation, and coordination. Utilizing novel, spatially disaggregated data on cell phone covera...

  6. Effect of action observation therapy on daily activities and motor recovery in stroke patients

    OpenAIRE

    Mei-Hong Zhu; Jing Wang; Xu-Dong Gu; Mei-Fang Shi; Ming Zeng; Chun-Yuan Wang; Qiao-Ying Chen; Jian-Ming Fu

    2015-01-01

    Objective: To evaluate the effects of action observation therapy, which is based on mirror neuron theory, on upper limb function and activities of daily living in patients with stroke. Methods: Sixty-one patients with stroke were randomly divided into two groups; those in the control group received routine rehabilitation treatment and nursing, whereas those in the experimental group additionally received eight weeks of action observation therapy for 30 min, six times per week. Patients rec...

  7. Adiponectin Action: A Combination of Endocrine and Autocrine/Paracrine Effects

    OpenAIRE

    Dadson, Keith; Liu, Ying; Sweeney, Gary

    2011-01-01

    The widespread physiological actions of adiponectin have now been well characterized as clinical studies and works in animal models have established strong correlations between circulating adiponectin level and various disease-related outcomes. Thus, conventional thinking attributes many of adiponectin’s beneficial effects to endocrine actions of adipose-derived adiponectin. However, it is now clear that several tissues can themselves produce adiponectin and there is growing evidence that loc...

  8. Adiponectin action: a combination of endocrine and autocrine/paracrine effects

    OpenAIRE

    Gary eSweeney

    2011-01-01

    The widespread physiological actions of adiponectin have now been well characterized as clinical studies and work in animal models have established strong correlations between circulating adiponectin levels and various disease-related outcomes. Thus, conventional thinking attributes many of adiponectins beneficial effects to endocrine actions of adipose-derived adiponectin. However, it is now clear that several tissues can themselves produce adiponectin and there is growing evidence that loca...

  9. Improving Conservation Community Group Effectiveness Using Mind Mapping and Action Research

    OpenAIRE

    Hanabeth Luke; David Lloyd; William Boyd; Kristin den Exter

    2014-01-01

    This paper examines a case study where mind mapping is used within an action research project to foster improved community group effectiveness and decision-making. The case study focusses on the social dynamics experienced during the formative stage of a community action group in Byron Bay, New South Wales; one of a network of such groups, formed to ensure that sustainable environmental management practices are followed in proposed coal-seam gas developments. In the context of examining syste...

  10. The differentiated effects of CSR actions in the service industry

    OpenAIRE

    Casado-Díaz, Ana B.; Nicolau, Juan Luis; Ruiz Moreno, Manuel Felipe; Sellers Rubio, Ricardo

    2014-01-01

    Purpose – The purpose of this study is to attempt to explain why the impact of Corporate Social Responsibility (CSR) initiatives may be different and/or more important in service firms compared to manufacturing firms. CSR is becoming a common strategy, hence its extensive research. Central to it is the analysis of the effect of CSR on a firm’s performance, whose outcome depends on firm-specific and industry-related factors. Design/methodology/approach – The event study methodology is applied ...

  11. Evolution of the violin: The law of effect in action.

    Science.gov (United States)

    Wasserman, Edward A; Cullen, Patrick

    2016-01-01

    As is true for most other human inventions, the origin of the violin is unknown. What is known is that this popular and versatile instrument has notably changed over the course of several hundred years. At issue is whether those evolutionary changes in the construction of the violin are the result of premeditated, intelligent design or whether they arose through a trial-and-error process. Recent scientific evidence favors the latter account. Our perspective piece puts these recent empirical findings into a comprehensive selectionist framework. According to this view, the many things we do and make--like violins--arise from a process of variation and selection which accords with the law of effect. Contrary to popular opinion, there is neither mystique nor romance in this process; it is as fundamental and ubiquitous as the law of natural selection. As with the law of natural selection in the evolution of organisms, there is staunch resistance to the role of the law of effect in the evolution of human inventions. We conclude our piece by considering several objections to our perspective. PMID:26569015

  12. Effective Swimmer’s Action during the Grab Start Technique

    Science.gov (United States)

    Mourão, Luis; de Jesus, Karla; Roesler, Hélio; Machado, Leandro J.; Fernandes, Ricardo J.; Vilas-Boas, João Paulo; Vaz, Mário A. P.

    2015-01-01

    The external forces applied in swimming starts have been often studied, but using direct analysis and simple interpretation data processes. This study aimed to develop a tool for vertical and horizontal force assessment based on the swimmers’ propulsive and structural forces (passive forces due to dead weight) applied during the block phase. Four methodological pathways were followed: the experimented fall of a rigid body, the swimmers’ inertia effect, the development of a mathematical model to describe the outcome of the rigid body fall and its generalization to include the effects of the inertia, and the experimental swimmers’ starting protocol analysed with the inclusion of the developed mathematical tool. The first three methodological steps resulted in the description and computation of the passive force components. At the fourth step, six well-trained swimmers performed three 15 m maximal grab start trials and three-dimensional (3D) kinetic data were obtained using a six degrees of freedom force plate. The passive force contribution to the start performance obtained from the model was subtracted from the experimental force due to the swimmers resulting in the swimmers’ active forces. As expected, the swimmers’ vertical and horizontal active forces accounted for the maximum variability contribution of the experimental forces. It was found that the active force profile for the vertical and horizontal components resembled one another. These findings should be considered in clarifying the active swimmers’ force variability and the respective geometrical profile as indicators to redefine steering strategies. PMID:25978370

  13. Evolution of the violin: The law of effect in action.

    Science.gov (United States)

    Wasserman, Edward A; Cullen, Patrick

    2016-01-01

    As is true for most other human inventions, the origin of the violin is unknown. What is known is that this popular and versatile instrument has notably changed over the course of several hundred years. At issue is whether those evolutionary changes in the construction of the violin are the result of premeditated, intelligent design or whether they arose through a trial-and-error process. Recent scientific evidence favors the latter account. Our perspective piece puts these recent empirical findings into a comprehensive selectionist framework. According to this view, the many things we do and make--like violins--arise from a process of variation and selection which accords with the law of effect. Contrary to popular opinion, there is neither mystique nor romance in this process; it is as fundamental and ubiquitous as the law of natural selection. As with the law of natural selection in the evolution of organisms, there is staunch resistance to the role of the law of effect in the evolution of human inventions. We conclude our piece by considering several objections to our perspective.

  14. Association of TNFRSF10D DNA-methylation with the survival of melanoma patients.

    Science.gov (United States)

    Ratzinger, Gudrun; Mitteregger, Simone; Wolf, Barbara; Berger, Regina; Zelger, Bernhard; Weinlich, Georg; Fritsch, Peter; Goebel, Georg; Fiegl, Heidelinde

    2014-07-07

    In this retrospective pilot study, the DNA-methylation status of genes that have been demonstrated to be involved in melanoma carcinogenesis was analyzed in order to identify novel biomarkers for the risk assessment of melanoma patients. We analyzed DNA extracted from punch-biopsies from 68 formalin-fixed paraffin-embedded (FFPE) melanoma specimens. Using MethyLight PCR, we examined 20 genes in specimens from a training set comprising 36 melanoma patients. Selected candidate genes were validated in a test set using FFPE tissue samples from 32 melanoma patients. First, we identified the TNFRSF10D DNA-methylation status (TNFRSF10D methylated vs. unmethylated) as a prognostic marker for overall (p = 0.001) and for relapse-free survival (p = 0.008) in the training set. This finding was confirmed in the independent test set (n = 32; overall survival p = 0.041; relapse-free survival p = 0.012). In a multivariate Cox-regression analysis including all patients, the TNFRSF10D DNA-methylation status remained as the most significant prognostic parameter for overall and relapse-free survival (relative-risk (RR) of death, 4.6 (95% CI: 2.0-11.0; p < 0.001), RR of relapse, 7.2 (95% CI: 2.8-18.3; p < 0.001)). In this study, we demonstrate that TNFRSF10D DNA-methylation analysis of a small tissue-punch from archival FFPE melanoma tissue is a promising approach to provide prognostic information in patients with melanoma.

  15. Association of TNFRSF10D DNA-Methylation with the Survival of Melanoma Patients

    Directory of Open Access Journals (Sweden)

    Gudrun Ratzinger

    2014-07-01

    Full Text Available In this retrospective pilot study, the DNA-methylation status of genes that have been demonstrated to be involved in melanoma carcinogenesis was analyzed in order to identify novel biomarkers for the risk assessment of melanoma patients. We analyzed DNA extracted from punch-biopsies from 68 formalin-fixed paraffin-embedded (FFPE melanoma specimens. Using MethyLight PCR, we examined 20 genes in specimens from a training set comprising 36 melanoma patients. Selected candidate genes were validated in a test set using FFPE tissue samples from 32 melanoma patients. First, we identified the TNFRSF10D DNA-methylation status (TNFRSF10D methylated vs. unmethylated as a prognostic marker for overall (p = 0.001 and for relapse-free survival (p = 0.008 in the training set. This finding was confirmed in the independent test set (n = 32; overall survival p = 0.041; relapse-free survival p = 0.012. In a multivariate Cox-regression analysis including all patients, the TNFRSF10D DNA-methylation status remained as the most significant prognostic parameter for overall and relapse-free survival (relative-risk (RR of death, 4.6 (95% CI: 2.0–11.0; p < 0.001, RR of relapse, 7.2 (95% CI: 2.8–18.3; p < 0.001. In this study, we demonstrate that TNFRSF10D DNA-methylation analysis of a small tissue-punch from archival FFPE melanoma tissue is a promising approach to provide prognostic information in patients with melanoma.

  16. Covariant and single-field effective action with the background-field formalism

    CERN Document Server

    Safari, Mahmoud

    2016-01-01

    In the context of scalar quantum field theory we introduce a class of generically nonlinear quantum-background splits for which the splitting Ward identity, encoding the single field dependence in the effective action, can be solved exactly. We show that this can be used to construct an effective action which is both covariant and dependent on the background and fluctuation fields only through a single total field in a way independent from the dynamics. Moreover we discuss the criteria under which the ultraviolet symmetries are inherited by the quantum effective action. The approach is demonstrated through some examples, including the $O(N)$ effective field theory, which might be of interest for the Higgs sector of the Standard Model or its extensions.

  17. The low-energy N=4 SYM effective action in diverse harmonic superspaces

    CERN Document Server

    Buchbinder, I L; Samsonov, I B

    2016-01-01

    We review various superspace approaches to the description of the low-energy effective action in N=4 super Yang-Mills (SYM) theory. We consider the four-derivative part of the low-energy effective action in the Coulomb branch. The typical components of this effective action are the gauge field F^4/X^4 and the scalar field Wess-Zumino terms. We construct N=4 supersymmetric completions of these terms in the framework of different harmonic superspaces supporting N=2,3,4 supersymmetries. These approaches are complementary to each other in the sense that they make manifest different subgroups of the total SU(4) R-symmetry group. We show that the effective action acquires an extremely simple form in those superspaces which manifest the non-anomalous maximal subgroups of SU(4). The common characteristic feature of our construction is that we restore the superfield effective actions exclusively by employing the N=4 supersymmetry and/or superconformal PSU(2,2|4) symmetry.

  18. Differential effects of thioridazine enantiomers on action potential duration in rabbit papillary muscle

    DEFF Research Database (Denmark)

    Jensen, Ask Schou; Pennisi, Cristian Pablo; Sevcencu, Cristian;

    2015-01-01

    with (+)-thioridazine. In this study we for the first time investigate the cardiotoxicity of the isolated thioridazine enantiomers and show their effects on ventricular repolarization. The effects of (+)-thioridazine, (-)-thioridazine, and racemate on the rabbit ventricular action potential duration (APD) were...... investigated in a randomized controlled blinded experiment. Action potentials were measured in papillary muscles isolated from 21 female rabbits, and the drug effect on 90% APD in comparison with control (DeltaDelta-APD90) was evaluated. Increasing concentrations of (+)-thioridazine and the racemate caused...

  19. Dynamical Tides in General Relativity: Effective Action and Effective-One-Body Hamiltonian

    CERN Document Server

    Steinhoff, Jan; Buonanno, Alessandra; Taracchini, Andrea

    2016-01-01

    Tidal effects have an important impact on the late inspiral of compact binary systems containing neutron stars. Most current models of tidal deformations of neutron stars assume that the tidal bulge is directly related to the tidal field generated by the companion, with a constant response coefficient. However, if the orbital motion approaches a resonance with one of the internal modes of the neutron star, this adiabatic description of tidal effects starts to break down, and the tides become dynamical. In this paper, we consider dynamical tides in general relativity due to the quadrupolar fundamental oscillation mode of a neutron star. We devise a description of the effects of the neutron star's finite size on the orbital dynamics based on an effective point-particle action augmented by dynamical quadrupolar degrees of freedom. We analyze the post-Newtonian and test-particle approximations of this model and incorporate the results into an effective-one-body Hamiltonian. This enables us to extend the descripti...

  20. Reviewing Biosphere Reserves globally: effective conservation action or bureaucratic label?

    Science.gov (United States)

    Coetzer, Kaera L; Witkowski, Edward T F; Erasmus, Barend F N

    2014-02-01

    The Biosphere Reserve (BR) model of UNESCO's Man and the Biosphere Programme reflects a shift towards more accountable conservation. Biosphere Reserves attempt to reconcile environmental protection with sustainable development; they explicitly acknowledge humans, and human interests in the conservation landscape while still maintaining the ecological values of existing protected areas. Conceptually, this model is attractive, with 610 sites currently designated globally. Yet the practical reality of implementing dual 'conservation' and 'development' goals is challenging, with few examples successfully conforming to the model's full criteria. Here, we review the history of Biosphere Reserves from first inception in 1974 to the current status quo, and examine the suitability of the designation as an effective conservation model. We track the spatial expansion of Biosphere Reserves globally, assessing the influence of the Statutory Framework of the World Network of Biosphere Reserves and Seville strategy in 1995, when the BR concept refocused its core objectives on sustainable development. We use a comprehensive range of case studies to discuss conformity to the Programme, the social and ecological consequences associated with implementation of the designation, and challenges in aligning conservation and development. Given that the 'Biosphere Reserve' label is a relatively unknown designation in the public arena, this review also provides details on popularising the Biosphere Reserve brand, as well as prospects for further research, currently unexploited, but implicit in the designation.

  1. Reviewing Biosphere Reserves globally: effective conservation action or bureaucratic label?

    Science.gov (United States)

    Coetzer, Kaera L; Witkowski, Edward T F; Erasmus, Barend F N

    2014-02-01

    The Biosphere Reserve (BR) model of UNESCO's Man and the Biosphere Programme reflects a shift towards more accountable conservation. Biosphere Reserves attempt to reconcile environmental protection with sustainable development; they explicitly acknowledge humans, and human interests in the conservation landscape while still maintaining the ecological values of existing protected areas. Conceptually, this model is attractive, with 610 sites currently designated globally. Yet the practical reality of implementing dual 'conservation' and 'development' goals is challenging, with few examples successfully conforming to the model's full criteria. Here, we review the history of Biosphere Reserves from first inception in 1974 to the current status quo, and examine the suitability of the designation as an effective conservation model. We track the spatial expansion of Biosphere Reserves globally, assessing the influence of the Statutory Framework of the World Network of Biosphere Reserves and Seville strategy in 1995, when the BR concept refocused its core objectives on sustainable development. We use a comprehensive range of case studies to discuss conformity to the Programme, the social and ecological consequences associated with implementation of the designation, and challenges in aligning conservation and development. Given that the 'Biosphere Reserve' label is a relatively unknown designation in the public arena, this review also provides details on popularising the Biosphere Reserve brand, as well as prospects for further research, currently unexploited, but implicit in the designation. PMID:23701641

  2. Effect of Action Video Games on the Spatial Distribution of Visuospatial Attention

    Science.gov (United States)

    Green, C. Shawn; Bavelier, Daphne

    2006-01-01

    The authors investigated the effect of action gaming on the spatial distribution of attention. The authors used the flanker compatibility effect to separately assess center and peripheral attentional resources in gamers versus nongamers. Gamers exhibited an enhancement in attentional resources compared with nongamers, not only in the periphery but…

  3. Extracting the effective Polyakov line action from SU(2) and SU(3) lattice gauge theories

    CERN Document Server

    Greensite, Jeff

    2013-01-01

    We describe the "relative weights" method used to compute the effective Polyakov line action corresponding to a given lattice gauge theory, and present some results that have been obtained so far. The main motivation is the sign problem, which may be easier to address in the effective theory than in the underlying gauge theory.

  4. Voluntary action and tactile sensory feedback in the intentional binding effect.

    Science.gov (United States)

    Zhao, Ke; Hu, Li; Qu, Fangbing; Cui, Qian; Piao, Qiuhong; Xu, Hui; Li, Yanyan; Wang, Liang; Fu, Xiaolan

    2016-08-01

    The intentional binding effect refers to a subjective compression over a temporal interval between the start point initialized by a voluntary action and the endpoint signaled by an external sensory (visual or audio) feedback. The present study aimed to explore the influence of tactile sensory feedback on this binding effect by comparing voluntary key-press actions with voluntary key-release actions. In experiment 1, each participant was instructed to report the perceived interval (in ms) between an action and the subsequent visual sensory feedback. In this task, either the action (key-press or key-release) was voluntarily performed by the participant or a kinematically identical movement was passively applied to the left index finger of the participant. In experiment 2, we explored whether the difference in the perception of time was affected by the direction of action. In experiment 3, we developed an apparatus in which two parallel laser beams were generated by a laser emission unit and detected by a laser receiver unit; this allowed the movement of the left index finger to be detected without it touching a keyboard (i.e., without any tactile sensory feedback). Convergent results from all of the experiments showed that the temporal binding effect was only observed when the action was both voluntary and involved physical contact with the key, suggesting that the combination of intention and tactile sensory feedback, as a form of top-down processing, likely distracted attention from temporal events and caused the different binding effects. PMID:27038203

  5. The combined effect of precession and convection on the dynamo action

    CERN Document Server

    Wei, Xing

    2016-01-01

    To understand the generation of the Earth's and planetary magnetic fields, we investigate numerically the combined effect of precession and convection on the dynamo action in a spherical shell. The convection alone, the precession alone and the combined effect of convection and precession are studied at the low Ekman number at which the precessing flow is already unstable. The key result is that although the precession or convection alone is not strong to support the dynamo action the combined effect of precession and convection can support the dynamo action because of the resonance of precessional and convective instabilities. This result may interpret why the geodynamo maintains for such a long history compared to the Martian dynamo.

  6. Gravitational effective action and entanglement entropy in UV modified theories with and without Lorentz symmetry

    Energy Technology Data Exchange (ETDEWEB)

    Nesterov, Dmitry, E-mail: nesterov@lpi.r [Laboratoire de Mathematiques et Physique Theorique, Universite Francois-Rabelais Tours, Federation Denis Poisson - CNRS, Parc de Grandmont, 37200 Tours (France)] [Theory Department, Lebedev Physical Institute, Leninsky Prospect 53, Moscow, Russia, 119991 (Russian Federation); Solodukhin, Sergey N., E-mail: Sergey.Solodukhin@lmpt.univ-tours.f [Laboratoire de Mathematiques et Physique Theorique, Universite Francois-Rabelais Tours, Federation Denis Poisson - CNRS, Parc de Grandmont, 37200 Tours (France)

    2011-01-11

    We calculate parameters in the low energy gravitational effective action and the entanglement entropy in a wide class of theories characterized by improved ultraviolet (UV) behavior. These include (i) local and non-local Lorentz invariant theories in which inverse propagator is modified by higher-derivative terms and (ii) theories described by non-Lorentz invariant Lifshitz type field operators. We demonstrate that the induced cosmological constant, gravitational couplings and the entropy are sensitive to the way the theory is modified in UV. For non-Lorentz invariant theories the induced gravitational effective action is of the Horava-Lifshitz type. We show that under certain conditions imposed on the dimension of the Lifshitz operator the couplings of the extrinsic curvature terms in the effective action are UV finite. Throughout the paper we systematically exploit the heat kernel method appropriately generalized for the class of theories under consideration.

  7. Two-loop low-energy effective action in Abelian supersymmetric Chern–Simons matter models

    International Nuclear Information System (INIS)

    We compute two-loop low-energy effective actions in Abelian Chern–Simons matter models with N=2 and N=3 supersymmetry up to four-derivative order. Calculations are performed with a slowly-varying gauge superfield background. Though the gauge superfield propagator depends on the gauge fixing parameter, it is shown that the obtained results are independent of this parameter. In the massless case the considered models are superconformal. We demonstrate that the superconformal symmetry strongly restricts the form of two-loop quantum corrections to the effective actions such that the obtained terms have simpler structure than the analogous ones in the effective action of three-dimensional supersymmetric electrodynamics (SQED) with vanishing topological mass

  8. Gauge Invariant Effective Action in Abelian Chiral Gauge Theory on the Lattice

    CERN Document Server

    Suzuki, H

    1999-01-01

    Lüscher's recent formulation of Abelian chiral gauge theories on the lattice, in the vacuum (or perturbative) sector in infinite lattice volume, is re-interpreted in terms of the lattice covariant regularization. The gauge invariance of the effective action and the integrability of the gauge current in anomaly-free cases become transparent then. The real part of the effective action is simply one-half of that of the Dirac fermion and, when the Dirac operator has proper properties in the continuum limit, the imaginary part in the continuum limit reproduces the $\\eta$-invariant.}

  9. Regular cosmological solutions in low energy effective action from string theories

    CERN Document Server

    Fabris, J C; Pinto-Neto, N; Peter, P; Peter, Patrick

    2003-01-01

    The possibility of obtaining singularity-free cosmological solutions in four dimensional effective actions motivated by string theory is investigated. In these effective actions, besides the Einstein-Hilbert term, the dilatonic and the axionic fields are also considered as well as terms coming from the Ramond-Ramond sector. A radiative fluid is coupled to the field equations, which appears as a consequence of the Maxwellian terms in the Ramond-Ramond sector. Singularity-free solutions are obtained when the dilatonic coupling constant is such that $\\omega - 3/2$.

  10. Covariant and background independent functional RG flow for the effective average action

    CERN Document Server

    Safari, Mahmoud

    2016-01-01

    We extend our prescription for the construction of a covariant and background-independent effective action for scalar quantum field theories to the case where momentum modes below a certain scale are suppressed by the presence of an infrared regulator. The key step is an appropriate choice of the infrared cutoff for which the Ward identity, capturing the information from single-field dependence of the ultraviolet action, continues to be exactly solvable, and therefore, in addition to covariance, manifest background independence of the effective action is guaranteed at any scale. A practical consequence is that in this framework one can adopt truncations dependent on the single total field. Furthermore we discuss the necessary and sufficient conditions for the preservation of symmetries along the renormalization group flow.

  11. Mitochondrial dysfunction has divergent, cell type-dependent effects on insulin action

    Science.gov (United States)

    Martin, Sheree D.; Morrison, Shona; Konstantopoulos, Nicky; McGee, Sean L.

    2014-01-01

    The contribution of mitochondrial dysfunction to insulin resistance is a contentious issue in metabolic research. Recent evidence implicates mitochondrial dysfunction as contributing to multiple forms of insulin resistance. However, some models of mitochondrial dysfunction fail to induce insulin resistance, suggesting greater complexity describes mitochondrial regulation of insulin action. We report that mitochondrial dysfunction is not necessary for cellular models of insulin resistance. However, impairment of mitochondrial function is sufficient for insulin resistance in a cell type-dependent manner, with impaired mitochondrial function inducing insulin resistance in adipocytes, but having no effect, or insulin sensitising effects in hepatocytes. The mechanism of mitochondrial impairment was important in determining the impact on insulin action, but was independent of mitochondrial ROS production. These data can account for opposing findings on this issue and highlight the complexity of mitochondrial regulation of cell type-specific insulin action, which is not described by current reductionist paradigms. PMID:24944900

  12. Effects of action planning and coping planning within the theory of planned behaviour

    DEFF Research Database (Denmark)

    Pakpour, Amir H.; Zedi, Isa mohammadi; Chatzisarantis, Nikos;

    2011-01-01

    Objective: Patients on dialysis have low physical activity levels. The aim of the study was to examine the validity of action planning and coping planning within the theory of planned behaviour framework, for predicting physical activity behaviour of patients on hemodialysis. Methods: One hundred...... and forty four patients who were undergoing emodialysis were selected from dialysis centers. The mean age of the patients was 56.61 (SD= 11.38) years. The patients completed a questionnaire including variables from the theory of planned behaviour, action planning and coping planning. Physical activity...... was prospectively assessed at 4-weeks with the validated International Physical Activity Questionnaire self-report measure. A hierarchical regression analysis was performed to examine the effects of action planning and coping planning on physical activity behaviour. Results: There was a main effect for coping...

  13. Community ACTION Boards: An Innovative Model for Effective Community–Academic Research Partnerships

    Science.gov (United States)

    James, Sherline; Arniella, Guedy; Bickell, Nina A.; Walker, Willie; Robinson, Virginia; Taylor, Barbara; Horowitz, Carol R.

    2012-01-01

    Background Community-based participatory research (CBPR) requires equitable partnerships between community stakeholders and academics. Traditionally, researchers relied on community advisory boards, but these boards often play a reactive role on a project-by-project basis. The East and Central Harlem Health Outcomes (ECHHO) Community Action Board (CAB), however, is an effective, proactive group. Objectives The ECHHO board sought to identify key strategies and tools to build and employ a partnership model, and to disseminate lessons learned to other community–academic partnerships. Methods Current and former board members were interviewed and a wide range of related documents was reviewed. Lessons Learned The board became effective when it prioritized action and relationship-building, across seven key domains: Shared priorities, diversity, participation, transparency, mutual respect and recognition, and personal connections. The model is depicted graphically. Conclusion Community advisory boards may benefit from attention to taking action, and to building relationships between academics and community members. PMID:22616207

  14. Applauding with closed hands: neural signature of action-sentence compatibility effects.

    Directory of Open Access Journals (Sweden)

    Pia Aravena

    Full Text Available BACKGROUND: Behavioral studies have provided evidence for an action-sentence compatibility effect (ACE that suggests a coupling of motor mechanisms and action-sentence comprehension. When both processes are concurrent, the action sentence primes the actual movement, and simultaneously, the action affects comprehension. The aim of the present study was to investigate brain markers of bidirectional impact of language comprehension and motor processes. METHODOLOGY/PRINCIPAL FINDINGS: Participants listened to sentences describing an action that involved an open hand, a closed hand, or no manual action. Each participant was asked to press a button to indicate his/her understanding of the sentence. Each participant was assigned a hand-shape, either closed or open, which had to be used to activate the button. There were two groups (depending on the assigned hand-shape and three categories (compatible, incompatible and neutral defined according to the compatibility between the response and the sentence. ACEs were found in both groups. Brain markers of semantic processing exhibited an N400-like component around the Cz electrode position. This component distinguishes between compatible and incompatible, with a greater negative deflection for incompatible. Motor response elicited a motor potential (MP and a re-afferent potential (RAP, which are both enhanced in the compatible condition. CONCLUSIONS/SIGNIFICANCE: The present findings provide the first ACE cortical measurements of semantic processing and the motor response. N400-like effects suggest that incompatibility with motor processes interferes in sentence comprehension in a semantic fashion. Modulation of motor potentials (MP and RAP revealed a multimodal semantic facilitation of the motor response. Both results provide neural evidence of an action-sentence bidirectional relationship. Our results suggest that ACE is not an epiphenomenal post-sentence comprehension process. In contrast, motor

  15. Effect of Fuzheng Huayu formula and its actions against liver fibrosis

    Directory of Open Access Journals (Sweden)

    Xu Lieming

    2009-06-01

    Full Text Available Abstract Liver fibrosis is a common histological process to develop into cirrhosis in various chronic liver diseases including chronic hepatitis and fatty liver. Therefore anti-liver fibrosis is very important strategy to treat chronic liver diseases. Fuzheng Huayu (FZHY, a preparation containing herbs such as Radix Salvia Miltiorrhizae, Cordyceps, Semen Persicae, was formulated on the basis of Chinese medicine theory in treating liver fibrosis and was approved. Pharmacological studies and clinical trials demonstrate that FZHY has a significant effect against liver fibrosis and that many of the pharmacological actions are attributable to the effect. This article reviews the effects and actions of FZHY, in particular the effects observed from clinical trials in treating liver fibrosis caused by chronic hepatitis B and the actions on inhibition of hepatic stellate cell activation, protection of hepatocytes and inhibition of hepatic sinusoidal capillarization. This article also reviews the coordinated effects of the constituent herbs of FZHY and the actions of their active compounds such as salvianonic acid B (SA-B on liver fibrosis.

  16. Effects of certain muscarinic antagonists on the actions of anticholinesterases on cat skeletal muscle.

    Science.gov (United States)

    Brimblecombe, R W; French, M C; Webb, S N

    1979-04-01

    1. The effects of some muscarinic antagonists, namely, N-ethyl-2-pyrrolidylmethyl-cyclopentylphenyl glycollate (PMCG), N-methyl-4-piperidyl-phenylcyclohexyl glycollate (PPCG, racemate and R and S enantiomers) and 4'-N-methyl-piperidyl-1-phenyl-cyclopentane carboxylate (G3063) on organophosphate (sarin, soman)- and carbamate (neostigmine)-induced twitch augmentation have been studied in cat soleus muscle. 2. The results of a preliminary study comparing the potency of sarin and soman in inhibiting the acetylcholinesterase activity of muscle in relation to the effect on the maximal twitch response indicated that there is not a simple relationship between degree of enzyme inhibition by these drugs and alteration of muscle function. 3. The muscarinic antagonists studied were capable of preventing or reversing sarin-, soman- or neostigmine-induced twitch augmentation. Doses sufficient to give complete protection from the effects of the anticholinesterase agents had little or no effect on the twitch response of normal muscle. 4. The protective action of these muscarinic antagonists is dose-dependent but independent of known antagonist actions at muscarinic receptors. 5. The effects of some local anaesthetics (lignocaine, prilocaine, cinchocaine, procaine) and other membrane stabilizers (quinine, ketamine, chlorpromazine, triflupromazine) were compared with those of the muscarinic antagonists in an attempt to elucidate the mode of action of these acetylcholine antagonists. The evidence is insufficient to exclude the involvement of a membrane stabilizing action. PMID:435681

  17. The combined effects of action observation and passive proprioceptive training on adaptive motor learning.

    Science.gov (United States)

    Lei, Yuming; Bao, Shancheng; Wang, Jinsung

    2016-09-01

    Sensorimotor adaptation can be induced by action observation, and also by passive training. Here, we investigated the effect of a protocol that combined action observation and passive training on visuomotor adaptation, by comparing it with the effect of action observation or passive training alone. Subjects were divided into five conditions during the training session: (1) action observation, in which the subjects watched a video of a model who adapted to a novel visuomotor rotation; (2) proprioceptive training, in which the subject's arm was moved passively to target locations that were associated with desired trajectories; (3) combined training, in which the subjects watched the video of a model during a half of the session and experienced passive movements during the other half; (4) active training, in which the subjects adapted actively to the rotation; and (5) a control condition, in which the subjects did not perform any task. Following that session, all subjects adapted to the same visuomotor rotation. Results showed that the subjects in the combined training condition adapted to the rotation significantly better than those in the observation or proprioceptive training condition, although their performance was not as good as that of those who adapted actively. These findings suggest that although a protocol that combines action observation and passive training consists of all the processes involved in active training (error detection and correction, effector-specific and proprioceptively based reaching movements), these processes in that protocol may work differently as compared to a protocol in which the same processes are engaged actively.

  18. The combined effects of action observation and passive proprioceptive training on adaptive motor learning.

    Science.gov (United States)

    Lei, Yuming; Bao, Shancheng; Wang, Jinsung

    2016-09-01

    Sensorimotor adaptation can be induced by action observation, and also by passive training. Here, we investigated the effect of a protocol that combined action observation and passive training on visuomotor adaptation, by comparing it with the effect of action observation or passive training alone. Subjects were divided into five conditions during the training session: (1) action observation, in which the subjects watched a video of a model who adapted to a novel visuomotor rotation; (2) proprioceptive training, in which the subject's arm was moved passively to target locations that were associated with desired trajectories; (3) combined training, in which the subjects watched the video of a model during a half of the session and experienced passive movements during the other half; (4) active training, in which the subjects adapted actively to the rotation; and (5) a control condition, in which the subjects did not perform any task. Following that session, all subjects adapted to the same visuomotor rotation. Results showed that the subjects in the combined training condition adapted to the rotation significantly better than those in the observation or proprioceptive training condition, although their performance was not as good as that of those who adapted actively. These findings suggest that although a protocol that combines action observation and passive training consists of all the processes involved in active training (error detection and correction, effector-specific and proprioceptively based reaching movements), these processes in that protocol may work differently as compared to a protocol in which the same processes are engaged actively. PMID:27298007

  19. Complementary Actions

    Directory of Open Access Journals (Sweden)

    Luisa eSartori

    2015-05-01

    Full Text Available Complementary colors are color pairs which, when combined in the right proportions, produce white or black. Complementary actions refer here to forms of social interaction wherein individuals adapt their joint actions according to a common aim. Notably, complementary actions are incongruent actions. But being incongruent is not sufficient to be complementary (i.e., to complete the action of another person. Successful complementary interactions are founded on the abilities: (i to simulate another person’s movements, (ii to predict another person’s future action/s, (iii to produce an appropriate incongruent response which differ, while interacting, with observed ones, and (iv to complete the social interaction by integrating the predicted effects of one’s own action with those of another person. This definition clearly alludes to the functional importance of complementary actions in the perception–action cycle and prompts us to scrutinize what is taking place behind the scenes. Preliminary data on this topic have been provided by recent cutting-edge studies utilizing different research methods. This mini-review aims to provide an up-to-date overview of the processes and the specific activations underlying complementary actions.

  20. Short Term Effectiveness of High Density Large Woody Debris in Asotin Creek as a Cheap and Cheerful Restoration Restoration Action

    OpenAIRE

    Camp, Reid

    2015-01-01

    In response to human impacts, river restoration and rehabilitation actions have become a priority in the United States. In the Pacific Northwest, most restoration actions are focused on repairing degraded freshwater habitat to increase or improve Pacific salmonid production. However, traditional river restoration actions remained largely unchanged for over 100 years despite a lack of definitive evidence that the actions were effective. More recently, there has been a surge in process-based re...

  1. The effective action for the 4-point functions in abelian open superstring theory

    NARCIS (Netherlands)

    de Roo, M; Eenink, MGC; Eenink, Martijn G.C.

    2003-01-01

    We construct the derivative corrections to the four-point vertices in the abelian open string effective action to all orders in alpha'. The result is based on the structure of the string four-point function. Supersymmetry of these vertices is guaranteed by the supersymmetry of the F-4 term in the ef

  2. Non-abelian chiral anomalies and Wess-Zumino effective actions

    International Nuclear Information System (INIS)

    An elementary account is given of the construction of anomalies and effective actions for Goldstone bosons, using the techniques of differential geometry. The emphasis is on simplicity of presentation, comparison of different renormalization schemes and the relationship to bosonization in the case of 2 dimensions. (Auth.)

  3. Nonperturbative corrections to 4D string theory effective actions from SL(2,Z) duality and supersymmetry.

    Science.gov (United States)

    Robles-Llana, Daniel; Rocek, Martin; Saueressig, Frank; Theis, Ulrich; Vandoren, Stefan

    2007-05-25

    We find the D(-1)- and D1-brane instanton contributions to the hypermultiplet moduli space of type IIB string compactifications on Calabi-Yau threefolds. These combine with known perturbative and world sheet instanton corrections into a single modular invariant function that determines the hypermultiplet low-energy effective action.

  4. Wogonin potentiates the antitumor action of etoposide and ameliorates its adverse effects.

    Science.gov (United States)

    Enomoto, Riyo; Koshiba, Chika; Suzuki, Chie; Lee, Eibai

    2011-05-01

    Wogonin, a flavone in the roots of Scutellaria baicalensis, reduced etoposide-induced apoptotic cell death in normal cells, such as bone marrow cells and thymocytes. On the other hand, wogonin potentiated the proapoptotic or cytotoxic action of etoposide in tumor cells, such as Jurkat, HL-60, A549, and NCI-H226. These contradictory actions of wogonin on apoptosis are distinguished by normal or cancer cell types. Wogonin had no effect on apoptosis induced by other anticancer agents in the tumor cells. Thus, the potentiation effect of wogonin was observed only in etoposide-induced apoptosis in tumor cells. In a functional assay for P-glycoprotein (P-gp), wogonin suppressed excretion of calcein, a substrate for P-gp, in these tumor cells. Moreover, wogonin decreased the excretion of radiolabeled etoposide and accordingly increased intracellular content of this agent in the cells. P-gp inhibitors showed a similar potentiation effect on etoposide-induced apoptosis in these tumor cells. Thus, wogonin is likely to potentiate the anticancer action of etoposide due to P-gp inhibition and accumulation of this agent. These findings suggest that wogonin may be a useful chemotherapeutic adjuvant to potentiate the pharmacological action of etoposide and ameliorate its adverse effects. PMID:20658136

  5. Coping with Sales Call Anxiety and Its Effects on Protective Actions

    NARCIS (Netherlands)

    F.D. Belschak (Frank); W.J.M.I. Verbeke (Willem); R.P. Bagozzi (Richard)

    2004-01-01

    textabstractWe study how salespeople cope with sales call anxiety and find that two tactics ultimately reduce dysfunctional protective actions in selling interactions. That is, situation modification and attentional deployment both moderate the effects of felt physiological sensations and anxiety o

  6. Modulatory effect of raloxifene and estrogen on the metabolic action of growth hormone in hypopituitary women.

    LENUS (Irish Health Repository)

    Birzniece, Vita

    2010-05-01

    The metabolic action of GH is attenuated by estrogens administered via the oral route. Selective estrogen receptor modulators lower IGF-I to a lesser degree than 17beta-estradiol in GH-deficient women, and their effect on fat and protein metabolism is unknown.

  7. Characterizing Teaching Effectiveness in the Joint Action Theory in Didactics: An Exploratory Study in Primary School

    Science.gov (United States)

    Sensevy, Gérard

    2014-01-01

    This paper presents an exploratory study of two consecutive reading sessions conducted in primary school by two different teachers. Our purpose is twofold. From a theoretical viewpoint, we propose a tentative set of conditions of teaching effectiveness by relying on the Joint Action Theory in Didactics. From a methodological viewpoint, drawing on…

  8. Effects of the "Positive Action" Program on Indicators of Positive Youth Development among Urban Youth

    Science.gov (United States)

    Lewis, Kendra M.; Vuchinich, Samuel; Ji, Peter; DuBois, David L.; Acock, Alan; Bavarian, Niloofar; Day, Joseph; Silverthorn, Naida; Flay, Brian R.

    2016-01-01

    This study evaluated effects of "Positive Action," a school-based social-emotional and character development intervention, on indicators of positive youth development (PYD) among a sample of low-income, ethnic minority youth attending 14 urban schools. The study used a matched-pair, cluster-randomized controlled design at the school…

  9. Using Action Research Interventions to Improve the Effectiveness of an Executive Team

    Science.gov (United States)

    McCarty, Timothy

    2010-01-01

    Purpose: The purpose of this study was to conduct an in-depth investigation of an executive team, to determine which internal and external factors impacted the team and to determine in what ways action research interventions improved the team's effectiveness. Methodology: The subjects in this study were seven members of a school district…

  10. Kappa-symmetry of superstring sigma model and generalized 10d supergravity equations

    CERN Document Server

    Wulff, L

    2016-01-01

    We determine the constraints imposed on the 10d target superspace geometry by the requirement of classical kappa-symmetry of the Green-Schwarz superstring. In the type I case we find that the background must satisfy a generalization of type I supergravity equations. These equations depend on an arbitrary vector X_a and imply the one-loop scale invariance of the GS sigma model. In the special case when X_a is the gradient of a scalar \\phi (dilaton) one recovers the standard type I equations equivalent to the 2d Weyl invariance conditions of the superstring sigma model. In the type II case we find a generalized version of the 10d supergravity equations the bosonic part of which was introduced in arXiv:1511.05795. These equations depend on two vectors \\X_a and K_a subject to 1st order differential relations (with the equations in the NS-NS sector depending only on the combination X_a = \\X_a + K_a). In the special case of K_a=0 one finds that \\X_a=\\d_a \\phi and thus obtains the standard type II supergravity equat...

  11. The Effect of Sympathetic Antagonists on the Antidepressant Action of Alprazolam

    Directory of Open Access Journals (Sweden)

    Gorash ZM

    2008-01-01

    Full Text Available Alprazolam is an anti-anxiety drug shown to be effective in the treatment of depression. In this study, the effect of sympathetic receptor antagonists on alprazolam–induced antidepressant action was studied using a mouse model of forced swimming behavioral despair. The interaction of three sympathetic receptor antagonists with benzodiazepines, which may impact the clinical use of alprazolam, was also studied. Behavioral despair was examined in six groups of albino mice. Drugs were administered intraperitoneally. The control group received only a single dose of 1% Tween 80. The second group received a single dose of alprazolam, and the third group received an antagonist followed by alprazolam. The fourth group was treated with imipramine, and the fifth group received an antagonist followed by imipramine. The sixth group was treated with a single dose of an antagonist alone (atenolol, a β1-selective adrenoceptor antagonist; propranolol, a non selective β-adrenoceptor antagonist; and prazocin, an α1-adrenoceptor antagonist. Results confirmed the antidepressant action of alprazolam and imipramine. Prazocin treatment alone produced depression, but it significantly potentiated the antidepressant actions of imipramine and alprazolam. Atenolol alone produced an antidepressant effect and potentiated the antidepressant action of alprazolam. Propranolol treatment alone produced depression, and antagonized the effects of alprazolam and imipramine, even producing depression in combined treatments. In conclusion, our results reveal that alprazolam may produce antidepressant effects through the release of noradrenaline, which stimulates β2 receptors to produce an antidepressant action. Imipramine may act by activating β2 receptors by blocking or down-regulating β1 receptors.

  12. Effects of benactyzine on action potentials and contractile force of guinea pig papillary muscles

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    Aim:To explore the effects of benactyzine (BEN) on the action potential and contractile force in guinea pig papillary muscles.Methods:Conventional microelectrode technique was used to record the fast action potentials (FAP) and slow action potentials (SAP) of guinea pig papillary muscles.Results:Benactyzine 5,10,50 μmol·L-1 suppressed the maximal upstroke velocity (vmax) of FAP and contractile force (Fc) concentration-dependently while prolonged the action potential duration at 50%,90% repolarization (APD50,APD90) and effective refractory period (ERP) of FAP.The suppression on the vmax was frequency-dependent.Benactyzine 5,10,50μmol·L-1 lengthened the APD50,APD90 of SAP induced by isoprenaline or histamine when perfused with KCl 22 mmol·L-1 Tyrode's solution.The vmax of the SAP was not decreased by benactyzine 5,10 μmol·L-1 but by 50 μmol·L-1.The effects on the SAP were antagonized by elevation of the extracellular calcium from 2.0 to 5.6 mmol·L-1.The effects of benactyzine on SAP elicited by tetrodotoxin resembled that by isoprenaline or histamine except the more pronounced suppression on vmax and action potential amplitude (APA).The persistent rapid spontaneous activity and triggered tachyarrhythmia induced by ouabain were also abolished immediately by benactyzine 5 μmol·L-1.Conclusion:Benactyzine can inhibit Na+,K+,Ca2+ transmembrane movement and intracellular Ca2+ mobilization in the myocardium,and this may be the electrophysiological basis of its effects against experimental arrhythmias.

  13. Induced low-energy effective action in the 6D, N = (1 , 0) hypermultiplet theory on the vector multiplet background

    Science.gov (United States)

    Buchbinder, I. L.; Merzlikin, B. S.; Pletnev, N. G.

    2016-08-01

    We consider the six dimensional N = (1 , 0) hypermultiplet model coupled to an external field of the Abelian vector multiplet in harmonic superspace approach. Using the superfield proper-time technique we find the divergent part of the effective action and derive the complete finite induced low-energy superfield effective action. This effective action depends on external field and contains in bosonic sector all the powers of the constant Maxwell field strength. The obtained result can be treated as the 6D, N = (1 , 0) supersymmetric Heisenberg-Euler type effective action.

  14. Employee Communicative Actions and Companies' Communication Strategies to Mitigate the Negative Effects of Crises

    DEFF Research Database (Denmark)

    Mazzei, Alessandra; Ravazzani, Silvia

    2013-01-01

    Abstract: Can communication with employees lessen the negative effects of a crisis? In the pre-crisis stage, employee communication can strengthen internal commitment, while in the crisis stage it can reinforce the commitment by means of accommodative crisis communication strategies. Employee...... commitment is at the basis of positive employee communicative actions, like advocacy and positive referrals, which finally protect the company’s reputation. After a theoretical exploration of these issues, this chapter presents first a case study showing how continuous internal communication efforts...... and factual communication based on managers’ and company’s actions are crucial in order to build quality relationships with employees. In turn, this leads to positive employee communicative actions when a crisis occurs. Second, it illustrates a survey of Italian companies which examined internal crisis...

  15. THE EFFECTS OF MAINTENANCE ACTIONS ON THE PFDavg OF SPRING OPERATED PRESSURE RELIEF VALVES

    Energy Technology Data Exchange (ETDEWEB)

    Harris, S.; Gross, R.

    2014-04-01

    The safety integrity level (SIL) of equipment used in safety instrumented functions is determined by the average probability of failure on demand (PFDavg) computed at the time of periodic inspection and maintenance, i.e., the time of proof testing. The computation of PFDavg is generally based solely on predictions or estimates of the assumed constant failure rate of the equipment. However, PFDavg is also affected by maintenance actions (or lack thereof) taken by the end user. This paper shows how maintenance actions can affect the PFDavg of spring operated pressure relief valves (SOPRV) and how these maintenance actions may be accounted for in the computation of the PFDavg metric. The method provides a means for quantifying the effects of changes in maintenance practices and shows how these changes impact plant safety.

  16. Feature activation during word recognition: action, visual, and associative-semantic priming effects

    Directory of Open Access Journals (Sweden)

    Kevin J.Y. Lam

    2015-05-01

    Full Text Available Embodied theories of language postulate that language meaning is stored in modality-specific brain areas generally involved in perception and action in the real world. However, the temporal dynamics of the interaction between modality-specific information and lexical-semantic processing remain unclear. We investigated the relative timing at which two types of modality-specific information (action-based and visual-form information contribute to lexical-semantic comprehension. To this end, we applied a behavioral priming paradigm in which prime and target words were related with respect to (1 action features, (2 visual features, or (3 semantically associative information. Using a Go/No-Go lexical decision task, priming effects were measured across four different inter-stimulus intervals (ISI = 100 ms, 250 ms, 400 ms, and 1,000 ms to determine the relative time course of the different features . Notably, action priming effects were found in ISIs of 100 ms, 250 ms, and 1,000 ms whereas a visual priming effect was seen only in the ISI of 1,000 ms. Importantly, our data suggest that features follow different time courses of activation during word recognition. In this regard, feature activation is dynamic, measurable in specific time windows but not in others. Thus the current study (1 demonstrates how multiple ISIs can be used within an experiment to help chart the time course of feature activation and (2 provides new evidence for embodied theories of language.

  17. Effects of acetylcholine and noradrenalin on action potentials of isolated rabbit sinoatrial and atrial myocytes

    Directory of Open Access Journals (Sweden)

    Arie O. Verkerk

    2012-05-01

    Full Text Available The autonomic nervous system controls heart rate and contractility through sympathetic and parasympathetic inputs to the cardiac tissue, with acetylcholine (ACh and noradrenalin (NA as the chemical transmitters. In recent years, it has become clear that specific Regulators of G protein Signalling proteins (RGS proteins suppress muscarinic sensitivity and parasympathetic tone, identifying RGS proteins as intriguing potential therapeutic targets. In the present study, we have identified the effects of 1 µM ACh and 1 µM NA on the intrinsic action potentials of sinotrial (SA nodal and atrial myocytes. Single cells were enzymatically isolated from the SA node or from the left atrium of rabbit hearts. Action potentials were recorded using the amphotericin-perforated patch-clamp technique in the absence and presence of ACh, NA or a combination of both. In SA nodal myocytes, ACh increased cycle length and decreased diastolic depolarization rate, whereas NA decreased cycle length and increased diastolic depolarization rate. Both ACh and NA increased maximum upstroke velocity. Furthermore, ACh hyperpolarized the maximum diastolic potential. In atrial myocytes stimulated at 2 Hz, both ACh and NA hyperpolarized the maximum diastolic potential, increased the action potential amplitude, and increased the maximum upstroke velocity. Action potential duration at 50 and 90% repolarization was decreased by ACh, but increased by NA. The effects of both ACh and NA on action potential duration showed a dose dependence in the range of 1–1,000 nM, while a clear-cut frequency dependence in the range of 1–4 Hz was absent. Intermediate results were obtained in the combined presence of ACh and NA in both SA nodal and atrial myocytes. Our data uncover the extent to which SA nodal and atrial action potentials are intrinsically dependent on ACh, NA or a combination of both and may thus guide further experiments with RGS proteins.

  18. Inverse Scattering Method and Soliton Solution Family for String Effective Action

    Institute of Scientific and Technical Information of China (English)

    GAO Ya-Jun

    2009-01-01

    A modified Hauser-Ernst-type linear system is established and used to develop an inverse scattering method for solving the motion equations of the string effective action describing the coupled gravity, dilaton and Kalb-Ramond fields. The reduction procedures in this inverse scattering method are found to be fairly simple, which makes the proposed inverse scattering method applied fine and effective. As an application, a concrete family of soliton solutions for the considered theory is obtained.

  19. Reducing aggressive intergroup action tendencies : effects of intergroup contact via perceived intergroup threat

    OpenAIRE

    Schmid, K.; Hewstone, M.; Küpper, B.; Zick, A.; Tausch, N.

    2014-01-01

    Katharina Schmid and Miles Hewstone gratefully acknowledge support from the Leverhulme Trust that facilitated the writing of this paper. Two studies tested the prediction that more positive intergroup contact would be associated with reduced aggressive intergroup action tendencies, an effect predicted to occur indirectly via reduced intergroup threat perceptions, and over and above well-established effects of contact on intergroup attitudes. Study 1, using data based on a cross-section of ...

  20. Wess-Zumino-Witten action and photons from the Chiral Magnetic Effect

    OpenAIRE

    Fukushima, Kenji; Mameda, Kazuya

    2012-01-01

    We revisit the Chiral Magnetic Effect (CME) using the chiral Lagrangian. We demonstrate that the electric-current formula of the CME is derived immediately from the contact part of the Wess-Zumino-Witten action. This implies that the CME could be, if observed, a signature for the local parity violation, but a direct evidence for neither quark deconfinement nor chiral restoration. We also discuss the reverse Chiral Magnetic Primakoff Effect, i.e. the real photon production through the vertex a...

  1. Promoting the translation of intentions into action by implementation intentions: Behavioral effects and physiological correlates

    Directory of Open Access Journals (Sweden)

    Frank eWieber

    2015-07-01

    Full Text Available The present review addresses the physiological correlates of planning effects on behavior. Although intentions to act qualify as predictors of behavior, accumulated evidence indicates that there is a substantial gap between even strong intentions and subsequent action. One effective strategy to reduce this intention-behavior gap is the formation of implementation intentions that specify when, where, and how to act on a given goal in an if-then format (If I encounter situation Y, then I will initiate action Z!. It has been proposed that implementation intentions render the mental representation of the situation highly accessible and establish a strong associative link between the mental representations of the situation and the action. These process assumptions have been examined in behavioral research, and in physiological research, a field that has begun to investigate the temporal dynamics of and brain areas involved in implementation intention effects. In the present review, we first summarize studies on the cognitive processes that are central to the strategic automation of action control by implementation intentions. We then examine studies involving critical samples with impaired self-regulation. Lastly, we review studies that have applied physiological measures such as heart rate, cortisol level, and eye movement, as well as electroencephalography (EEG and functional magnetic resonance imaging (fMRI studies on the neural correlates of implementation intention effects. In support of the assumed processes, implementation intentions increased goal attainment in studies on cognitive processes and in critical samples, modulated brain waves related to perceptual and decision processes, and generated less activity in brain areas associated with effortful action control. In our discussion, we reflect on the status quo of physiological research on implementation intentions, methodological and conceptual issues, related research, and propose future

  2. Linear Response Theory for Symmetry Improved Two Particle Irreducible Effective Actions

    CERN Document Server

    Brown, Michael J; Kosov, Daniel S

    2016-01-01

    We investigate the linear response of an O(N) scalar quantum field theory subject to external perturbations using the symmetry improved two particle irreducible effective action formalism [A. Pilaftsis and D. Teresi, Nucl. Phys. B874, 594 (2013)]. Despite satisfactory equilibrium behavior, we find a number of unphysical effects at the linear response level. Goldstone boson field fluctuations are over-determined, with the only consistent solution being to set the fluctuations and their driving sources to zero, except for momentum modes where the Higgs and Goldstone self-energies obey a particular relationship. Also Higgs field fluctuations propagate masslessly, despite the Higgs propagator having the correct mass. These pathologies are independent of any truncation of the effective action and still exist even if we relax the over-determining Ward identities, so long as the constraint is formulated O(N)-covariantly. We discuss possible reasons for the apparent incompatibility of the constraints and linear respo...

  3. Linear response theory for symmetry improved two particle irreducible effective actions

    Science.gov (United States)

    Brown, Michael J.; Whittingham, Ian B.; Kosov, Daniel S.

    2016-05-01

    We investigate the linear response of an O (N ) scalar quantum field theory subject to external perturbations using the symmetry-improved two-particle irreducible effective action (SI-2PIEA) formalism [A. Pilaftsis and D. Teresi, Nucl. Phys. B874, 594 (2013)]. Despite satisfactory equilibrium behavior, we find a number of unphysical effects at the linear response level. Goldstone boson field fluctuations are overdetermined, with the only consistent solution being to set the fluctuations and their driving sources to zero, except for momentum modes where the Higgs and Goldstone self-energies obey a particular relationship. Also Higgs field fluctuations propagate masslessly, despite the Higgs propagator having the correct mass. These pathologies are independent of any truncation of the effective action and still exist even if we relax the overdetermining Ward identities, so long as the constraint is formulated O (N ) covariantly. We discuss possible reasons for the apparent incompatibility of the constraints and linear response approximation and possible ways forward.

  4. Mixed Heavy-Light Matching in the Universal One-Loop Effective Action

    CERN Document Server

    Ellis, Sebastian A R; You, Tevong; Zhang, Zhengkang

    2016-01-01

    Recently, a general result for evaluating the path integral at one loop was obtained in the form of the Universal One-Loop Effective Action. It may be used to derive effective field theory operators of dimensions up to six, by evaluating the traces of matrices in this expression, with the mass-dependence encapsulated in the universal coefficients. Here we show that it can account for loops of mixed heavy-light particles in the matching procedure. Our prescription for computing these mixed contributions to the Wilson coefficients is conceptually simple. Moreover it has the advantage of maintaining the universal structure of the effective action, which we illustrate using the example of integrating out a heavy electroweak triplet scalar coupling to a light Higgs doublet. Finally we also identify new structures that were previously neglected in the universal results.

  5. Entrainment and task co-representation effects for discrete and continuous action sequences.

    Science.gov (United States)

    van der Wel, Robrecht P R D; Fu, En

    2015-12-01

    A large body of work has established an influence of other people's actions on our own actions. For example, actors entrain to the movements of others, in studies that typically employ continuous movements. Likewise, studies on co-representation have shown that people automatically co-represent a co-actor's task, in studies that typically employ discrete actions. Here we examined entrainment and co-representation within a single task paradigm. Participants sat next to a confederate while simultaneously moving their right hand back and forth between two targets. We crossed whether or not the participant and the confederate moved over an obstacle and manipulated whether participants generated discrete or continuous movement sequences, while varying the space between the actors and whether the actors could see each other's movements. Participants moved higher when the confederate cleared an obstacle than when he did not. For continuous movements, this effect depended on the availability of visual information, as would be expected on the basis of entrainment. In contrast, the co-actor's task modulated the height of discrete movements, regardless of the availability of visual information, which is consistent with co-representation. Space did not have an effect. These results provide new insights into the interplay between co-representation and entrainment for discrete- and continuous-action tasks. PMID:25911443

  6. High efficiency, blue emitting materials based on phenanthro[9,10-d]imidazole derivatives

    Energy Technology Data Exchange (ETDEWEB)

    Jayabharathi, J., E-mail: jtchalam2005@yahoo.co.in; Sathishkumar, R.; Thanikachalam, V.; Jayamoorthy, K.

    2014-09-15

    The blue light emitting materials based on a fluoro phenanthro [9,10-d] imidazole derivatives prepared by a facial synthetic process exhibit good thermal stability, highly efficient fluorescence and balanced carrier injection. The multi-layered device based on fluoro phenanthroimidazole derivatives shows a higher luminance in a lower turn-on voltage. The device performance implies that the phenanthroimidazole unit is an excellent building block for tuning the carrier injection properties as well as blue emission. - Highlights: • Phenanthroimidazole exhibits high T{sub m} and T{sub d5} values, fluorescent efficiency, preparation cost and charge injection property. • The carrier injection and transport ability can be evidenced from the hole-only and electron-only devices. • These materials are used as building block for efficient blue light emitting materials. • Chemical structure modification improving the materials' properties.

  7. Effectiveness and sustainability of remedial actions for land restoration in Abeokuta urban communities, Ogun State, Nigeria

    Science.gov (United States)

    Lawal-Adebowale, Okanlade

    2016-04-01

    Land as a major collective human property faces a great deal of threats and eventual degradation from both natural and human causal factors across the globe. But for the central role of land in human's sustenance and quality living, man cannot afford to lose its natural asset and as such takes mitigating or remedial actions to save and restore his land for sustainable use. In view of this, the study assessed the causal factors of land degradation in urban areas of Abeokuta and effectiveness and sustainability of the taken remedial actions to stem the tide of land degradation in the study area. The selected communities were purposively selected based on the observed prevalence of degraded lands in the areas. A qualitative research approach which encompasses observational techniques - participant/field observation, interactive discussion and photographic capturing, was used for collection of data on land degradation in the study area. A combination of phenomenological, inductive thematic analysis and conversation/discourse analysis was employed for data analysis. The results showed land gradients/slopes, rainfall, run-offs/erosion, land-entrenched foot impacts, sand scraping/mining, poor/absence of drainage system and land covers as causal factors of land degradation in the study area. The employed remedial actions for restoration of degraded land included filling of drenches with sand bags, wood logs, bricks and stones, and sand filling. The study though observed that filling of drenches caused by erosion with rubles/stones and construction of drainage were effective remedial actions, good drainage system was presumed to be the most appropriate and sustainable remedial action for land restoration in the study area.

  8. Comment on ''Functional integral for Weyl fermions and the effective action''

    Energy Technology Data Exchange (ETDEWEB)

    Banerjee, R.; Banerjee, H.

    1989-02-15

    Baaklini's method of obtaining the effective action for Weyl fermions is shown to yield either a gauge-invariant or a gauge-variant form depending on the specific definition employed in the analysis. The structures of the effective action proposed by Baaklini are found to correspond to the standard expressions.

  9. Remarks on effective action and entanglement entropy of Maxwell field in generic gauge

    CERN Document Server

    Solodukhin, Sergey N

    2012-01-01

    We analyze the dependence of the effective action and the entanglement entropy in the Maxwell theory on the gauge fixing parameter $a$ in $d$ dimensions. For a generic value of $a$ the corresponding vector operator is nonminimal. The operator can be diagonalized in terms of the transverse and longitudinal modes. Using this factorization we obtain an expression for the heat kernel coefficients of the nonminimal operator in terms of the coefficients of two minimal Beltrami-Laplace operators acting on 0- and 1-forms. This expression agrees with an earlier result by Gilkey et al. Working in a regularization scheme with the dimensionful UV regulators we introduce three different regulators: for transverse, longitudinal and ghost modes, respectively. We then show that the effective action and the entanglement entropy do not depend on the gauge fixing parameter $a$ provided the certain ($a$-dependent) relations are imposed on the regulators. Comparing the entanglement entropy with the black hole entropy expressed in...

  10. A note on scaling arguments in the effective average action formalism

    CERN Document Server

    Pagani, Carlo

    2016-01-01

    The effective average action (EAA) is a scale dependent effective action where a scale $k$ is introduced via an infrared regulator. The $k-$dependence of the EAA is governed by an exact flow equation to which one associates a boundary condition at a scale $\\mu$. We show that the $\\mu-$dependence of the EAA is controlled by an equation fully analogous to the Callan-Symanzik equation which allows to define scaling quantities straightforwardly. Particular attention is paid to composite operators which are introduced along with new sources. We discuss some simple solutions to the flow equation for composite operators and comment their implications in the case of a local potential approximation.

  11. Supplemental action learning workshops: Understanding the effects of independent and cooperative workshops on students' knowledge

    Science.gov (United States)

    Morris, Kathryn Michelle

    Community colleges enroll more than half of the undergraduate population in the United States, thereby retaining students of varying demographics with extracurricular demands differing from traditional four-year university students. Often in a collegiate lecture course, students are limited in their abilities to absorb and process information presented by their instructors due to content-specific cognitive gaps between the instructor and the student (Preszler, 2009). Research has shown that implementation of instructor-facilitated action learning workshops as supplemental instruction may help bridge these cognitive gaps allowing better student conceptualization and dissemination of knowledge (Drake, 2011; Fullilove & Treisman, 1990; Preszler, 2009; Udovic, Morris, Dickman, Postlethwait, & Wetherwax, 2002). The purpose of this study was to determine the effects of cooperative action learning workshops and independent action learning workshops on students' knowledge of specified topics within a General Biology I with lab course. The results of this investigation indicate that implementation of an instructor-facilitated action learning workshop did not affect students' knowledge gain; furthermore, attendance of a particular workshop style (independent or cooperative) did not affect students' knowledge gain.

  12. Amplitudes Topologiques et l'Action Effective de la Théorie des Cordes

    OpenAIRE

    Zein Assi, Ahmad

    2013-01-01

    In this thesis, we study a class of higher derivative couplings in the string effective action arising at the junction of topological string theory and supersymmetric gauge theories in the Omega-background. They generalise a series of gravitational couplings involving gravitons and graviphotons, which reproduces the topological string theory partition function. The latter reduces, in the field theory limit, to the partition function of the gauge theory in the Omega-background when one if its ...

  13. Effect of intrathecal baclofen on the monosynaptic reflex in humans: evidence for a postsynaptic action.

    OpenAIRE

    Azouvi, P; Roby-Brami, A.; Biraben, A; Thiebaut, J B; Thurel, C; Bussel, B

    1993-01-01

    Intrathecal baclofen is a very powerful antispastic agent. Its mechanism of action on the monosynaptic H-reflex in spinal patients was investigated. It could inhibit rapidly and profoundly monosynaptic reflexes in lower limbs, but did not modify Ia vibratory inhibition of the soleus H-reflex. To assess more precisely its effect on Ia afferents, an experimental paradigm using Ia heteronymous facilitation of the soleus H-reflex was used. Intrathecal baclofen did not modify the amount of monosyn...

  14. On the application of the effective action approach to amplitudes with reggeon splitting

    International Nuclear Information System (INIS)

    Application of the effective action approach to amplitudes with loop integration is studied for collisions on two and three centers with possible gluon emission. A rule is formulated for the integration around pole singularities in the induced vertices which brings the results in agreement with the QCD. It is demonstrated that the amplitudes can be restored from the purely transverse picture by introducing the standard Feynman propagators for intermediate gluons and quarks. (orig.)

  15. Improved hard-thermal-loop effective action for hot QED and QCD

    CERN Document Server

    Flechsig, F; Flechsig, Fritjof; Rebhan, Anton K

    1995-01-01

    The conventional results for hard thermal loops, which are the building blocks of resummed perturbation theory in thermal field theories, have collinear singularities when external momenta are light-like. It is shown that by taking into account asymptotic thermal masses these singularities are removed. The thus improved hard thermal loops can be summarized by compact gauge-invariant effective actions, generalizing the ones found by Taylor and Wong, and by Braaten and Pisarski.

  16. Low energy effective action on a self-gravitating D-brane

    CERN Document Server

    Onda, S; Koyama, K; Hayakawa, S; Onda, Sumitada; Shiromizu, Tetsuya; Koyama, Kazuya; Hayakawa, Shoko

    2003-01-01

    Recently the study of braneworld on the self-gravitating D-brane has been initiated and derived the gravitational equation on the brane by holographic and geometrical projection methods. Surprisingly, in common with these two methods, the matter on the brane cannot be the source of the gravity on the brane at leading order. In this paper we will propose the low energy effective action on the D-brane coupled with gravity which derives the same results.

  17. Effects of action of ultrasound with capsaicin in the treatment of post traumatic pathology

    Directory of Open Access Journals (Sweden)

    Ioan OSWALD

    2007-05-01

    Full Text Available There are numerous methods of administering drugs to the body,both passive and active. A recent review of the literature on phonophoresis reports that 75 % of the studies reviewed reported positive effects, ultrasound energy with drugs like gel or cream can travel through body tissue. Capsaicin was the active ingredient in hot chilli peppers has selection actions on unmyelinated C fibres and thinly myelinated A primary sensory neurones.

  18. Partially Massless Higher-Spin Theory II: One-Loop Effective Actions

    CERN Document Server

    Brust, Christopher

    2016-01-01

    We continue our study of a generalization of the D-dimensional linearized Vasiliev higher-spin equations to include a tower of partially massless (PM) fields. We compute one-loop effective actions by evaluating zeta functions for both the "minimal" and "non-minimal" parity-even versions of the theory. Specifically, we compute the log-divergent part of the effective action in odd-dimensional Euclidean AdS spaces for D=7 through 19 (dual to the $a$-type conformal anomaly of the dual boundary theory), and the finite part of the effective action in even-dimensional Euclidean AdS spaces for D=4 through 8 (dual to the free energy on a sphere of the dual boundary theory). We pay special attention to the case D=4, where module mixings occur in the dual field theory and subtlety arises in the one-loop computation. The results provide evidence that the theory is UV complete and one-loop exact, and we conjecture and provide evidence for a map between the inverse Newton's constant of the partially massless higher-spin th...

  19. Observing grasping actions directed to emotion-laden objects: effects upon corticospinal excitability

    Directory of Open Access Journals (Sweden)

    Anaelli A Nogueira-Campos

    2016-08-01

    Full Text Available The motor system is recruited whenever one executes an action as well as when one observes the same action being executed by others. Although it is well established that emotion modulates the motor system, the effect of observing other individuals acting in an emotional context is particularly elusive. The main aim of this study was to investigate the effect induced by the observation of grasping directed to emotion-laden objects upon corticospinal excitability (CSE. Participants classified video-clips depicting the right-hand of an actor grasping emotion-laden objects. Twenty video-clips differing in terms of valence but balanced in arousal level were selected. Motor evoked potentials (MEPs were then recorded from the first dorsal interosseous using transcranial magnetic stimulation (TMS while the participants observed the selected emotional video-clips. During the video-clip presentation, TMS pulses were randomly applied at one of two different time points of grasping: (1 maximum grip aperture, and (2 object contact time. CSE was higher during the observation of grasping directed to unpleasant objects compared to pleasant ones. These results indicate that when someone observes an action of grasping directed to emotion-laden objects, the effect of the object valence promotes a specific modulation over the motor system.

  20. Observing Grasping Actions Directed to Emotion-Laden Objects: Effects upon Corticospinal Excitability.

    Science.gov (United States)

    Nogueira-Campos, Anaelli A; Saunier, Ghislain; Della-Maggiore, Valeria; De Oliveira, Laura A S; Rodrigues, Erika C; Vargas, Claudia D

    2016-01-01

    The motor system is recruited whenever one executes an action as well as when one observes the same action being executed by others. Although it is well established that emotion modulates the motor system, the effect of observing other individuals acting in an emotional context is particularly elusive. The main aim of this study was to investigate the effect induced by the observation of grasping directed to emotion-laden objects upon corticospinal excitability (CSE). Participants classified video-clips depicting the right-hand of an actor grasping emotion-laden objects. Twenty video-clips differing in terms of valence but balanced in arousal level were selected. Motor evoked potentials (MEPs) were then recorded from the first dorsal interosseous using transcranial magnetic stimulation (TMS) while the participants observed the selected emotional video-clips. During the video-clip presentation, TMS pulses were randomly applied at one of two different time points of grasping: (1) maximum grip aperture, and (2) object contact time. CSE was higher during the observation of grasping directed to unpleasant objects compared to pleasant ones. These results indicate that when someone observes an action of grasping directed to emotion-laden objects, the effect of the object valence promotes a specific modulation over the motor system. PMID:27625602

  1. Interference effects of two and three super-tall buildings under wind action

    Institute of Scientific and Technical Information of China (English)

    Ming Gu; Zhuang-Ning Xie

    2011-01-01

    Most previous investigations on interference effects of tall buildings under wind actions focused on the wind induced interference effects between two buildings,and the interference effects of three or more buildings have seldom been studied so far due to the huge workload involved in experiments and data processing.In this paper,mean and dynamic force/response interference effects and peak wind pressure interference effects of two and three tall buildings,especially the three-building configuration,are investigated through a series of wind tunnel tests on typical tall building models using high frequency force balance technique and wind pressure measurements.Furthermore,the present paper focuses on the effects of parameters,including breadth ratio and height ratio of the buildings and terrain category,on the interference factors and derives relevant regression results for the interference factors.

  2. Induced parity violating thermal effective action for (2+1)-dimensional fermions interacting with a non-Abelian background

    International Nuclear Information System (INIS)

    We study the parity breaking effective action in 2+1 dimensions, generated, at finite temperature, by massive fermions interacting with a non-Abelian gauge background. We explicitly calculate, in the static limit, parity violating amplitudes up to the seven point function, which allows us to determine the corresponding effective actions. There are two classes of such actions that arise: namely, terms that do not manifestly depend on E(vector sign) and ones that do. We derive the exact effective action that is not manifestly dependent on E(vector sign). For the other class that depends explicitly on E(vector sign), there are families of terms that can be determined order by order in perturbation theory. We attempt to generalize our results to nonstatic backgrounds through the use of time ordered exponentials and prove gauge invariance, both small and large, of the resulting effective action. We also point out some open questions that need to be further understood

  3. Learning to control actions: transfer effects following a procedural cognitive control computerized training.

    Directory of Open Access Journals (Sweden)

    Nitzan Shahar

    Full Text Available Few studies have addressed action control training. In the current study, participants were trained over 19 days in an adaptive training task that demanded constant switching, maintenance and updating of novel action rules. Participants completed an executive functions battery before and after training that estimated processing speed, working memory updating, set-shifting, response inhibition and fluid intelligence. Participants in the training group showed greater improvement than a no-contact control group in processing speed, indicated by reduced reaction times in speeded classification tasks. No other systematic group differences were found across the different pre-post measurements. Ex-Gaussian fitting of the reaction-time distribution revealed that the reaction time reduction observed among trained participants was restricted to the right tail of the distribution, previously shown to be related to working memory. Furthermore, training effects were only found in classification tasks that required participants to maintain novel stimulus-response rules in mind, supporting the notion that the training improved working memory abilities. Training benefits were maintained in a 10-month follow-up, indicating relatively long-lasting effects. The authors conclude that training improved action-related working memory abilities.

  4. Motivating Exercise: The Interactive Effect of General Action Goals and Past Behavior on Physical Activity.

    Science.gov (United States)

    Hepler, Justin; Wang, Wei; Albarracin, Dolores

    2012-09-01

    Although exercise is recognized as a powerful tool to combat obesity, remarkably few US adults pursue adequate amounts of exercise, with one major impediment being a lack of motivation for active behaviors. Recent empirical work has demonstrated that behavior can be guided by goals to be generally active or inactive. In the present paper, an experiment is presented in which participants played or observed a video game, were primed with action or inaction goals, and practiced a stretching exercise for as long as desired. Exposure to environmental action cues led to increased time spent exercising. This effect was moderated by past behavior, such that individuals who had just engaged in an active task (played a videogame) were insensitive to attempts to motivate general action. This suggests that the effectiveness of attempts to motivate activity ("just do it", "be active") hinges on the recent past-behavior of the targeted individuals. An implication of this work is that participation in certain leisure activities, such as playing videogames, may be causally related to a lack of motivation for exercise.

  5. Effective-action approach to wave propagation in scalar QED plasmas

    Science.gov (United States)

    Shi, Yuan; Fisch, Nathaniel J.; Qin, Hong

    2016-07-01

    A relativistic quantum field theory with nontrivial background fields is developed and applied to study waves in plasmas. The effective action of the electromagnetic 4-potential is calculated ab initio from the standard action of scalar QED using path integrals. The resultant effective action is gauge invariant and contains nonlocal interactions, from which gauge bosons acquire masses without breaking the local gauge symmetry. To demonstrate how the general theory can be applied, we give two examples: a cold unmagnetized plasma and a cold uniformly magnetized plasma. Using these two examples, we show that all linear waves well known in classical plasma physics can be recovered from relativistic quantum results when taking the classical limit. In the opposite limit, classical wave dispersion relations are modified substantially. In unmagnetized plasmas, longitudinal waves propagate with nonzero group velocities even when plasmas are cold. In magnetized plasmas, anharmonically spaced Bernstein waves persist even when plasmas are cold. These waves account for cyclotron absorption features observed in spectra of x-ray pulsars. Moreover, cutoff frequencies of the two nondegenerate electromagnetic waves are red-shifted by different amounts. These corrections need to be taken into account in order to correctly interpret diagnostic results in laser plasma experiments.

  6. Acute effects of specific actions after the “on your marks” command

    Directory of Open Access Journals (Sweden)

    IOANNIS KESOGLOU

    2016-04-01

    Full Text Available Improved temporal sequencing of high – intensity muscle contractions prior to the sprint start may maximize motoneuron excitability and may enhance fast twitch fiber recruitment and sprint start effectiveness. The aim of the study was to assess a the electromyographic activity of the gastrocnemius lateralis, biceps femoris and vastus femoris muscles under exposure to specific voluntary, dynamic actions (quick skipping or tuck jumps that sometimes sprinters perform after the “on your marks” command and to an external involuntary stimulus (WBV-whole body vibration and b the effectiveness of the above stimuli applied on the activation level of lower limb muscles in order to produce neuromuscular activation the very last moment just behind the blocks, as this is measured by the RT and time in 1.5m and 3m after the sprint start.Ten male sprinters executed sprint starts under 4 experimental conditions after the “on your marks command”: 1st condition – without performing any action, 2nd performing tuck jumps, 3rd performing quick skipping and 4th after being exposed to vibration stimuli. No significant difference in average muscle activity was observed after evaluation of the EMG raw data for the tuck jumps and quick skipping actions. No significant differences were, also, observed for RT and time in 1.5m and 3m in conditions 2 to 4.

  7. Effects of terpineol on the compound action potential of the rat sciatic nerve

    OpenAIRE

    M.R. Moreira; G.M.P. Cruz; Lopes, M S; A.A.C. Albuquerque; J.H. Leal-Cardoso

    2001-01-01

    Terpineol, a volatile terpenoid alcohol of low toxicity, is widely used in the perfumery industry. It is an important chemical constituent of the essential oil of many plants with widespread applications in folk medicine and in aromatherapy. The effects of terpineol on the compound action potential (CAP) of rat sciatic nerve were studied. Terpineol induced a dose-dependent blockade of the CAP. At 100 µM, terpineol had no demonstrable effect. At 300 µM terpineol, peak-to-peak amplitude and con...

  8. On modelling of physical effects accompanying the propagation of action potentials in nerve fibres

    CERN Document Server

    Engelbrecht, Jüri; Tamm, Kert; Laasmaa, Martin; Vendelin, Marko

    2016-01-01

    The recent theoretical and experimental studies have revealed many details of signal propagation in nervous systems. In this paper an attempt is made to unify various mathematical models which describe the signal propagation in nerve fibres. The analysis of existing single models permits to select the leading physiological effects. As a result, a more general mathematical model is described based on the coupling of action potentials with mechanical waves in a nerve fibre. The crucial issue is how to model coupling effects which are strongly linked to the ion currents through biomembranes.

  9. Next-to-leading gluonic reggeons in the high-energy effective action

    CERN Document Server

    Kirschner, R

    1998-01-01

    We study the next-to-leading gluon exchange in the high-energy scattering that contributes to the amplitude to order $s^0$ up to logarithmic corrections. Similar to the leading gluon exchange these contribution can be described in terms of reggeon exchanges. There are several gluonic reggeons at the next-to-leading level. Some of them transfer parity or gauge group representation different from the leading gluonic reggeon. Unlike the leading one they are sensitive to the helicity and transverse momenta of the scattering partons. We extend the high-energy effective action and derive from the action of gluodynamics the terms describing the next-to-leading reggeons and their interaction in the multi-Regge approximation.

  10. Impact of nutritional labelling on 10-d energy intake, appetite perceptions and attitudes towards food.

    Science.gov (United States)

    Carbonneau, Elise; Perron, Julie; Drapeau, Vicky; Lamarche, Benoît; Doucet, Éric; Pomerleau, Sonia; Provencher, Véronique

    2015-12-28

    The purpose of this study was to investigate the impact of nutritional labelling on energy intake, appetite perceptions and attitudes towards food. During a 10-d period, seventy normal-weight (BMIlabelling groups in which the only difference was the label posted on lunch meal entrée: (1) low-fat label, (2) energy label (energy content of the entrée and average daily needs) and (3) no label (control). Average energy intake was calculated by weighing all foods before v. after daily consumption. Hunger and fullness perceptions were rated on visual analogue scales immediately before and after each meal. Satiety efficiency was assessed through the calculation of the satiety quotient (SQ). The appreciation and perceived healthiness of the lunch entrées were rated on eight-point Likert scales. There was no difference in energy intake, SQ and attitudes towards food between the three labelling groups. Fasting hunger perception was higher in the low-fat label group compared with the two others groups (P=0·0037). No interactions between labelling groups and BMI categories were observed. In conclusion, although labelling does not seem to influence energy intake, a low-fat label may increase women's fasting hunger perceptions compared with an energy label or no label.

  11. Photochemical Conversion of Phenanthro[9,10-d]imidazoles into π-Expanded Heterocycles.

    Science.gov (United States)

    Skonieczny, Kamil; Gryko, Daniel T

    2015-06-01

    We discovered that phenanthro[9,10-d]imidazoles bearing a 2-halogenoaryl substituent at position 2 undergo swift photochemically driven direct arylation, leading to barely known phenanthro[9',10':4,5]imidazo[1,2-f]phenanthridines. The reaction is high-yielding, and it does not require any sensitizer or base. The discovered process is tolerant of a variety of substituents present both at positions 1 and 2; i.e., strongly electron-donating and electron-withdrawing substituents are tolerated as well as various heterocyclic units. Steric hindrance does not affect this process. The evidence gathered here indicates that SRN1 mechanism is operating in this case with the formation of radical anion as a critical step, followed by heterolytic cleavage of a carbon-halogen bond. Also TfO groups were shown to undergo cyclization, which allows the use of salicylaldehydes in the construction of heterocyclic systems. Efficiency of this photochemically driven direct arylation has been demonstrated by the synthesis of two systems possessing 13 and 17 conjugated rings, respectively. Phenanthro[9',10':4,5]imidazo[1,2-f]phenanthridines are blue-emitters, and they exhibit strong fluorescence in solution and in the solid state in direct contrast to their precursors. PMID:25938658

  12. Alignment effects in beer mugs: Automatic action activation or response competition?

    Science.gov (United States)

    Roest, Sander A; Pecher, Diane; Naeije, Lilian; Zeelenberg, René

    2016-08-01

    Responses to objects with a graspable handle are faster when the response hand and handle orientation are aligned (e.g., a key press with the right hand is required and the object handle is oriented to the right) than when they are not aligned. This effect could be explained by automatic activation of specific motor programs when an object is viewed. Alternatively, the effect could be explained by competition at the response level. Participants performed a reach-and-grasp or reach-and-button-press action with their left or right hand in response to the color of a beer mug. The alignment effect did not vary as a function of the type of action. In addition, the alignment effect disappeared in a go/no-go version of the task. The same results were obtained when participants made upright/inverted decisions, so that object shape was task-relevant. Our results indicate that alignment effects are not due to automatic motor activation of the left or right limb.

  13. Alignment effects in beer mugs: Automatic action activation or response competition?

    Science.gov (United States)

    Roest, Sander A; Pecher, Diane; Naeije, Lilian; Zeelenberg, René

    2016-08-01

    Responses to objects with a graspable handle are faster when the response hand and handle orientation are aligned (e.g., a key press with the right hand is required and the object handle is oriented to the right) than when they are not aligned. This effect could be explained by automatic activation of specific motor programs when an object is viewed. Alternatively, the effect could be explained by competition at the response level. Participants performed a reach-and-grasp or reach-and-button-press action with their left or right hand in response to the color of a beer mug. The alignment effect did not vary as a function of the type of action. In addition, the alignment effect disappeared in a go/no-go version of the task. The same results were obtained when participants made upright/inverted decisions, so that object shape was task-relevant. Our results indicate that alignment effects are not due to automatic motor activation of the left or right limb. PMID:27184058

  14. Tetrandrine and related bis-benzylisoquinoline alkaloids from medicinal herbs: cardiovascular effects and mechanisms of action

    Institute of Scientific and Technical Information of China (English)

    Chiu-Yin KWAN; FI ACHIKE

    2002-01-01

    Tetrandrine (TET), a bis-benzylisoquinoline alkaloid purified and identified an active ingredient in a Chinese medicinal herb, Radix Stephanae tetrandrae, has been used traditionally for the treatment of congestive circulatory disorder and inflammatory diseases. TET, together with a few of its structural analogues, has long been demonstrated to have antihypertensive action in clinical as well as animal studies. Presumably, the primary anti-hypertensive action of TET is due to its vasodilatory properties. TET prevents or inhibits vascular contraction induced by membrane depolarization with KCl or α-adrenoceptor activation with phenylephrine (PE). TET (30 μmol/L) also inhibits the release of endothelium-derived nitric oxide (NO) as well as NO production by inducible NO synthase.TET apparently inhibits multiple Ca2+ entry pathways as demonstrated in cell types lacking the L-type Ca2+ channels.In cardiac muscle cells, TET inhibits both L- and T-type Ca2+ channels. In addition to its actions on cardiovascular tissues, TET may also exert its anti-hypertensive action via a Ca2+-dependent manner on other tissues intimately involved in the modulation of blood pressure control, such as adrenal glands. In adrenal glomerulosa cells, KCl- or angiotensin II-induced aldosterone synthesis is highly dependent on extracellular Ca2+. Steroidogenesis and Ca2+-influx in bovine adrenal glomerulosa cells have been shown to be potently inhibited by TET. In bovine adrenal chromaffin cells, TET inhibits Ca2+ currents via L- and N-type channels as well as other unidentified channels with IC50 of 10 μmol/L. Other than the Ca2+ antagonistic effects, TET also interacts with the α-adrenergic receptors and muscarinic receptors based on functional as well as radioligand binding studies. Apart from its functional effects,TET and related compounds also exert effects on tissue structures, such as remodelling of hypertrophied heart and inhibition of angiogenesis, probably by causing apoptotic

  15. Effect of Sr90 and ethanol on work ability in case of combined and separate action of these factors

    International Nuclear Information System (INIS)

    Effect of 90Sr and ethanol on workability of white mice males in long-term experiment is studied. It is shown that dynamic workability is decreased to a greater extent at 90Sr effect than at ethanol one. The data on predominance of the effects of combined action of these factors are obtained. Differences in time regularities of dose-effect dependence for the studied factors make it difficult to get a unique answer to the question about the character of combined action. By most factors a slight increase of combined radionuclide and ethanol effect in the end of experiment, as well as accelerated decrease of muscular work, are detected. Lower radionuclide doses hat no effect on the value of combined action that is totally referred to ethanol action

  16. The high energy behavior of QCD. The effective action and the triple-Pomeron-vertex

    Energy Technology Data Exchange (ETDEWEB)

    Hentschinski, Martin

    2009-07-15

    We study integrations over light-cone momenta in the high energy effective action of QCD. After a brief review of the effective action, we arrive on a regularization mechanism from matching of effective action diagrams with QCD diagrams, which we apply to a re-derivation of the reggeized gluon and of the BFKL-equation. We study consequences of the proposed regularization on the analytic structure of 2{yields}3 and 2{yields}4 production amplitudes in the Multi-Regge-Kinematics. We derive a certain part of the 1-loop corrections to the production vertex and demonstrate that they yield the on-set of corrections demanded by the Steinmann-relations. The Reggeon-Particle-2-Reggeon vertex is determined and applied to the construction of various signature configurations of the production amplitudes. We extend the proposed regularization method to states of three and four reggeized gluons and propose a supplement to the effective Lagrangian. We derive vertices for the 1-3 and 2-4 reggeized-gluon-transition inside the elastic amplitude and verify that signature conservation is obeyed. Integral equations for the state of three and four reggeized gluons are formulated and shown to be in accordance with a result by Bartels and Wuesthoff. In a second part we investigate the high-energy behavior of QCD for different surface topologies of color graphs. After a brief review of the planar limit (bootstrap and gluon reggeization) and of the cylinder topology (BFKL) we investigate the 3{yields}3 scattering in the triple Regge limit which belongs to the pair-of-pants topology. We re-derive the triple Pomeron vertex function and show that it belongs to a specific set of graphs in color space which we identify as the analog of the Mandelstam diagram. We then extend the study to the high-energy behavior of N=4 SYM where we find a new class of color graphs not present in QCD. (orig.)

  17. A functional approach to quantum friction: effective action and dissipative force

    CERN Document Server

    Farías, M Belén; Lombardo, Fernando C; Mazzitelli, Francisco D; López, Adrián E Rubio

    2014-01-01

    We study the Casimir friction due to the relative, uniform, lateral motion of two parallel mirrors coupled to a vacuum real scalar field, $\\phi$. We follow a functional approach, whereby nonlocal terms in the action for $\\phi$, concentrated on the mirrors' locii, appear after functional integration of the microscopic degrees of freedom. This action for $\\phi$, which incorporates the relevant properties of the mirrors, is then used as the starting point for two complementary evaluations: Firstly, we calculate the { in-out} effective action for the system, which develops an imaginary part, hence a non-vanishing probability for the decay (because of friction) of the initial vacuum state. Secondly, we evaluate another observable: the vacuum expectation value of the frictional force, using the { in-in} or Closed Time Path formalism. Explicit results are presented for zero-width mirrors and half-spaces, in a model where the microscopic degrees of freedom at the mirrors are a set of identical quantum harmonic oscill...

  18. Gauge Coupling Field, Currents, Anomalies and N=1 Super-Yang-Mills Effective Actions

    CERN Document Server

    Ambrosetti, Nicola; Derendinger, Jean-Pierre; Hartog, Jelle

    2016-01-01

    Working with a gauge coupling field in a linear superfield, we construct effective Lagrangians for N=1 super-Yang-Mills theory fully compatible with the expected all-order behaviour or physical quantities. Using the one-loop dependence on its ultraviolet cutoff and anomaly matching or cancellation of R and dilatation anomalies, we obtain the Wilsonian effective Lagrangian. With similar anomaly matching or cancellation methods, we derive the effective action for gaugino condensates, as a function of the real coupling field. Both effective actions lead to a derivation of the NSVZ beta function from algebraic arguments only. The extension of results to N=2 theories or to matter systems is briefly considered. The main tool for the discussion of anomalies is a generic supercurrent structure with 16_B+16_F operators (the S multiplet), which we derive using superspace identities and field equations for a fully general gauge theory Lagrangian with the linear gauge coupling superfield, and with various U(1)_R currents...

  19. Improving Conservation Community Group Effectiveness Using Mind Mapping and Action Research

    Directory of Open Access Journals (Sweden)

    Hanabeth Luke

    2014-01-01

    Full Text Available This paper examines a case study where mind mapping is used within an action research project to foster improved community group effectiveness and decision-making. The case study focusses on the social dynamics experienced during the formative stage of a community action group in Byron Bay, New South Wales; one of a network of such groups, formed to ensure that sustainable environmental management practices are followed in proposed coal-seam gas developments. In the context of examining systemic social interactions within such a group, the study recognises both the importance of communication and the susceptibility of individuals to certain behavioural patterns. Negative emergent norms led to excessive behaviours that threatened to hinder effective communication and group behaviour. Use of mind mapping countered this negative tendency, focussing the inherent positive qualities of the group, and thus enabling more efficient decision-making. Shown to be an effective tool for overcoming communication barriers and increasing cohesion; its power lies in maintaining process transparency, removing power-structures and ego-centric personal barriers, hence facilitating effective communal knowledge sharing, clarification, idea crystallisation, and planning.

  20. Perturbative Computation of the Gluonic Effective Action via Polyaokov's World-Line Path Integral

    CERN Document Server

    Avramis, S D; Ktorides, C N

    2002-01-01

    The Polyakov world-line path integral describing the propagation of gluon field quanta is constructed by employing the background gauge fixing method and is subsequently applied to analytically compute the divergent terms of the one (gluonic) loop effective action to fourth order in perturbation theory. The merits of the proposed approach is that, to a given order, it reduces to performing two integrations, one over a set of Grassmann and one over a set of Feynman-type parameters through which one manages to accomodate all Feynman diagrams entering the computation at once.

  1. Three-dimensional noncommutative Yukawa theory: Induced effective action and propagating modes

    CERN Document Server

    Bufalo, R

    2016-01-01

    In this paper, we establish the analysis of noncommutative Yukawa theory, encompassing neutral and charged scalar fields. We approach the analysis by considering carefully the derivation of the respective effective actions. Hence, based on the obtained results, we compute the one-loop contributions to the neutral and charged scalar field self-energy, as well as to the Chern-Simons polarization tensor. In order to properly define the behaviour of the quantum fields, the known UV/IR mixing due to radiative corrections is analysed in the one-loop physical dispersion relation of the scalar and gauge fields.

  2. Effects of Potassium Currents upon Action Potential of Cardiac Cells Exposed to External Electric fields

    Institute of Scientific and Technical Information of China (English)

    An-Ying Zhang; Xiao-Feng Pang

    2008-01-01

    Previous studies show that exposure to high-voltage electric fields would influence the electro cardiogram both in experimental animate and human beings. The effects of the external electric fields upon action potential of cardiac cells are studied in this paper based on the dynamical model, LR91. Fourth order Runger-Kuta is used to analyze the change of potassium ion channels exposed to external electric fields in detail. Results indicate that external electric fields could influence the current of potassium ion by adding an induced component voltage on membrane. This phenomenon might be one of the reasons of heart rate anomaly under the high-voltage electric fields.

  3. Evaluation of the Antibacterial Effects and Mechanism of Action of Protocatechualdehyde against Ralstonia solanacearum

    Directory of Open Access Journals (Sweden)

    Shili Li

    2016-06-01

    Full Text Available Protocatechualdehyde (PCA is an important plant-derived natural product that has been associated with a wide variety of biological activities and has been widely used in medicine as an antioxidant, anti-aging and an anti-inflammatory agent. However, fewer reports concerning its antibacterial effects on plant-pathogenic bacteria exist. Therefore, in this study, protocatechualdehyde was evaluated for its antibacterial activity against plant pathogens along with the mechanism of its antibacterial action. PCA at 40 μg/mL was highly active against R. solanacearum and significantly inhibited its growth. The minimum bactericidal concentration and minimum inhibitory concentration values for PCA were 40 μg/mL and 20 μg/mL, respectively. Further investigation of the mechanism of action of PCA via transmission electron microscopy and biological assays indicated that the destruction of the cell structure, the shapes and the inhibition of biofilm formation were important. In addition, the application of PCA effectively reduced the incidence of bacterial wilt on tobacco under greenhouse conditions, and the control efficiency was as high as 92.01% at nine days after inoculation. Taken together, these findings suggest that PCA exhibits strong antibacterial activity against R. solanacearum and has the potential to be applied as an effective antibacterial agent for controlling bacterial wilt caused by R. solanacearum.

  4. Effects of triclocarban on intact immature male rat: augmentation of androgen action.

    Science.gov (United States)

    Duleba, Antoni J; Ahmed, Mohamed I; Sun, Meng; Gao, Allen C; Villanueva, Jesus; Conley, Alan J; Turgeon, Judith L; Benirschke, Kurt; Gee, Nancy A; Chen, Jiangang; Green, Peter G; Lasley, Bill L

    2011-02-01

    Triclocarban (TCC; 3,4,4'-trichlorocarbanilide) is an antimicrobial agent used widely in various personal hygiene products including soaps. Recently, TCC has been shown to enhance testosterone-induced effects in vitro and to enlarge accessory sex organs in castrated male rats. This study was designed to evaluate the effects of TCC on intact age-matched male rats and on human prostate LNCaP and C4-2B cells. Seven-week-old male Sprague-Dawley rats received either a normal diet or a diet supplemented with TCC (0.25% in diet) for 10 days. Triclocarban induced hyperplasia of accessory sex organs in the absence of significant qualitative histological changes. Serum luteinizing hormone (LH) and testosterone were not significantly altered by TCC treatment. In prostate cancer-derived LNCaP and C4-2B cells, TCC potentiated androgen actions via androgen receptor-dependent actions. In conclusion, TCC significantly affects intact male reproductive organs and potentiates androgen effects in prostate cancer cells. PMID:20889956

  5. Anomaly-induced effective action and Chern–Simons modification of general relativity

    Energy Technology Data Exchange (ETDEWEB)

    Mauro, Sebastião [Departamento de Física, ICE, Universidade Federal de Juiz de Fora, CEP: 36036-330, Juiz de Fora, MG (Brazil); Shapiro, Ilya L., E-mail: ilyashapiro2003@yahoo.com.br [Département de Physique Théorique and Center for Astroparticle Physics, Université de Genève, 24 quai Ansermet, CH-1211 Genéve 4 (Switzerland); Departamento de Física, ICE, Universidade Federal de Juiz de Fora, CEP: 36036-330, Juiz de Fora, MG (Brazil); Tomsk State Pedagogical University and Tomsk State University, Tomsk, 634041 (Russian Federation)

    2015-06-30

    Recently it was shown that the quantum vacuum effects of massless chiral fermion field in curved space–time leads to the parity-violating Pontryagin density term, which appears in the trace anomaly with imaginary coefficient. In the present work the anomaly-induced effective action with the parity-violating term is derived. The result is similar to the Chern–Simons modified general relativity, which was extensively studied in the last decade, but with the kinetic terms for the scalar different from those considered previously in the literature. The parity-breaking term makes no effect on the zero-order cosmology, but it is expected to be relevant in the black hole solutions and in the cosmological perturbations, especially gravitational waves.

  6. Effective action for the Regge processes in QCD and in gravity

    Energy Technology Data Exchange (ETDEWEB)

    Lipatov, L.N. [Petersburg Nuclear Physics Institute (Russian Federation); Hamburg Universitaet (Germany)

    2011-10-15

    It is known, that the Gribov approach to the hadron-hadron high energy scattering is based on an effective field theory for the Pomeron interactions. The gluons and gravitons are reggeized and therefore it is natural to reformulate QCD and gravity at high energies in terms of the reggeons and their interactions. We review the basic ideas of the BFKL approach in QCD and in supersymmetric gauge models and present it in the form of the gauge-invariant effective theory for the reggeized gluon interactions. A similar generally covariant action for the reggeized gravitons is formulated in terms of effective currents satisfying the Hamilton-Jacobi equation. Its supersymmetric generalization is discussed.

  7. Effects of berberine in the gastrointestinal tract - a review of actions and therapeutic implications.

    Science.gov (United States)

    Chen, Chunqiu; Yu, Zhen; Li, Yongyu; Fichna, Jakub; Storr, Martin

    2014-01-01

    Berberine is an isoquinoline alkaloid present in several plant species, including Coptis sp. and Berberis sp. In traditional medicine, extracts of berberine are used in the treatment of diarrhea of different origins. Recent studies have shown that berberine and its derivatives have significant biological effects on gastrointestinal (GI) and other functions and may become therapeutics for the treatment of diarrhea, gastroenteritis, diabetes, hyperlipidemia, cardiovascular diseases and inflammatory conditions. This paper summarizes the current knowledge on the actions of berberine in the GI tract. Binding and target sites, activated intracellular pathways, as well as the absorption and metabolism of berberine are discussed. Effects that may be useful in future clinical treatment, like antidiarrheal, anti-inflammatory and antitumor effects are critically reviewed and potential clinical applications are presented in detail. PMID:25183302

  8. Novel insights into lithium's mechanism of action: neurotrophic and neuroprotective effects.

    Science.gov (United States)

    Quiroz, Jorge A; Machado-Vieira, Rodrigo; Zarate, Carlos A; Manji, Husseini K

    2010-01-01

    The monovalent cation lithium partially exerts its effects by activating neurotrophic and neuroprotective cellular cascades. Here, we discuss the effects of lithium on oxidative stress, programmed cell death (apoptosis), inflammation, glial dysfunction, neurotrophic factor functioning, excitotoxicity, and mitochondrial stability. In particular, we review evidence demonstrating the action of lithium on cyclic adenosine monophosphate (cAMP)-mediated signal transduction, cAMP response element binding activation, increased expression of brain-derived neurotrophic factor, the phosphatidylinositide cascade, protein kinase C inhibition, glycogen synthase kinase 3 inhibition, and B-cell lymphoma 2 expression. Notably, we also review data from clinical studies demonstrating neurotrophic effects of lithium. We expect that a better understanding of the clinically relevant pathophysiological targets of lithium will lead to improved treatments for those who suffer from mood as well as neurodegenerative disorders.

  9. National Wildlife Refuge System Action Plan : Response to Independent Evaluation of the Effectiveness of the Refuge System

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This action plan is the first in what the Leadership Team intends to be a recurring annual plan to monitor and address overall Refuge System effectiveness. The plan...

  10. Biological Effects of Contact Action of 1470 vs. 810 nm Semiconductor Lasers in vitro

    Directory of Open Access Journals (Sweden)

    Schumilova N.A.

    2014-12-01

    Full Text Available The aim of the investigation is to identify the character of biological effects of contact action of semiconductor laser with a wavelength of 1470 nm on the tissues with different optical and mechanical properties compared to the exposure to laser radiation with a wavelength of 810 nm. Materials and Methods. The study was performed on a chicken muscle tissue, liver of the cattle, nasal polyp, removed nasal septum cartilage. While making a linear incision of the tissues by the laser with a speed of 2 mm/s assessment of the width of ablation and coagulation zones, and the crater depth with the following measurement under the microscopy conditions were carried on. Weighing of the tissue specimens before and after the spot action was performed. Standardization of the operating speed was achieved by using uniformly moving recorder chart. Results. Radiation power increment of 1470 nm wavelength laser contributes to the increase of the ablation and coagulation zone width to a greater degree compared to 810 nm laser. Exposure to 1470 nm laser with a power of 1 W causes the tissue to stick to the fiber. When power is 2 W, coagulation zone of soft tissues is comparable, and in some cases exceeds it after treatment by 810 nm laser. In relation to the crater depth, 1470 nm radiation is inferior to 810 nm radiation, but is superior in relation to vaporization abilities. Conclusion. For tissue ablation with 1470 nm laser a power of 2 W is optimal, as it provides a sparing superficial effect, and in a number of cases exceeds the action of 810 nm 7 W laser by its coagulation properties. Generation of a crater with a less depth after application of 1470 nm laser allows it to be recommended for superficial coagulation of vascular lesions.

  11. Toxicity, sublethal effects, and potential modes of action of select fungicides on freshwater fish and invertebrates

    Science.gov (United States)

    Elskus, Adria A.

    2012-01-01

    Despite decades of agricultural and urban use of fungicides and widespread detection of these pesticides in surface waters, relatively few data are available on the effects of fungicides on fish and invertebrates in the aquatic environment. Nine fungicides are reviewed in this report: azoxystrobin, boscalid, chlorothalonil, fludioxonil, myclobutanil, fenarimol, pyraclostrobin, pyrimethanil, and zoxamide. These fungicides were identified as emerging chemicals of concern because of their high or increasing global use rates, detection frequency in surface waters, or likely persistence in the environment. A review of the literature revealed significant sublethal effects of fungicides on fish, aquatic invertebrates, and ecosystems, including zooplankton and fish reproduction, fish immune function, zooplankton community composition, metabolic enzymes, and ecosystem processes, such as leaf decomposition in streams, among other biological effects. Some of these effects can occur at fungicide concentrations well below single-species acute lethality values (48- or 96-hour concentration that effects a response in 50 percent of the organisms, that is, effective concentration killing 50 percent of the organisms in 48 or 96 hours) and chronic sublethal values (for example, 21-day no observed adverse effects concentration), indicating that single-species toxicity values may dramatically underestimate the toxic potency of some fungicides. Fungicide modes of toxic action in fungi can sometimes reflect the biochemical and (or) physiological effects of fungicides observed in vertebrates and invertebrates; however, far more studies are needed to explore the potential to predict effects in nontarget organisms based on specific fungicide modes of toxic action. Fungicides can also have additive and (or) synergistic effects when used with other fungicides and insecticides, highlighting the need to study pesticide mixtures that occur in surface waters. For fungicides that partition to

  12. Different goods, different effects: Exploring the effects of generalized social trust in large-N collective action

    DEFF Research Database (Denmark)

    Sønderskov, Kim Mannemar

    2009-01-01

    Does generalized social trust help solve large-N collective action problems? This paper argues so, offering a novel explanation for the relationship: People tend to cooperate if they expect others to be cooperating, which implies that people holding generalized social trust more readily cooperate...... in large-N dilemmas because they expect that most people will cooperate. The paper tests the explanation in a rigorous design. The analyses show a positive, robust effect of generalized social trust on public good provision, but no effect is found in a joint product situation. This supports the hypothesis...

  13. EFFECTIVENESS OF A PARTICIPATORY ACTION ORIENTED TRAINING INTERVENTION APPROACH AMONG HARVESTERS IN OIL PALM PLANTATION

    Directory of Open Access Journals (Sweden)

    Ng Yee Guan

    2014-01-01

    Full Text Available Consistent with the global demand for palm oil, the intensified upstream harvesting activities of oil palms’ fresh fruit bunches, despite the harvesters evidences of various ergonomics risk factors leading to musculoskeletal disorders should be a cause for concern. Thus, this study describes the effectiveness of a modified and locally adapted Participatory Action-Oriented Training intervention program in improving the working environment of the harvesters. A training program modified and customized to the harvesters’ working in oil palm plantation consist of 3 primary instrument (awareness video, interactive lecture and action checklist with 3 reinforcing activities (to increase knowledge, enhance understanding and practical application. Based on the result of post-intervention assessment, the self-reported prevalence of MSD and KAP score among Intervention Group (IG did not significantly differ from Control Group (CG. Instead of decreasing, the prevalence of MSD in the past 12 months and 7 days increased within IG. Qualitative findings in this research show that the negative psychosocial and organizational climate has severely affected the implementation of PAOT rendering the effect of the intervention approach. The interventions were ineffective on the IG as this study suffers from various situational barriers as obstacles to benefit the full extent of PAOT advantages.

  14. Effects of the action of hydrogen peroxide on the electrical properties of polyaniline-aluminium composites

    Energy Technology Data Exchange (ETDEWEB)

    Gmati, Fethi; Manaii, Aymen; Mohamed, Abdellatif Belhadj [Laboratory of Photovoltaic (LPV), Centre of Research and Technology of Energy (CRTEn), Technopole of Borj Cedria, Hammam Lif 2050 (Tunisia); Fattoum, Arbi, E-mail: gmati_fethi@yahoo.fr [Unit of Research: Materials Environment and Energy (06/UR/12-01), Faculty of Sciences Gafsa (Tunisia)

    2011-08-10

    The effects of the action of hydrogen peroxide (H{sub 2}O{sub 2}) as an oxidizing agent on the electrical properties of polyaniline-aluminium (PANI-Al) composites are studied. Direct current (dc) electrical conductivity is investigated in the temperature range 303-453 K. A decrease in the conductivity with attack time is observed. The results are compatible with UV-visible and infrared absorption measurements and scanning electron microscopy analysis. The experimental data show a transition from a negative temperature coefficient of resistivity (TCR) to a positive TCR. This transition becomes more pronounced when the attack time increases. Depending on the H{sub 2}O{sub 2} attack time, we found that the dc conductivity of the composites is described by two distinct models: the first is a series combination between the fluctuation-induced tunnelling (FIT) model with a metallic transport model, the second is a combination between Mott's three-dimensional variable range hopping with an intrinsic metallic model. The different FIT and Mott parameters are evaluated. The change in the conduction mechanism is attributed to the disorder and the localization effect caused by the action of H{sub 2}O{sub 2} on the PANI-Al composite.

  15. Influence of extra training means on effectiveness of fencers’ technical tactic actions

    Directory of Open Access Journals (Sweden)

    Lopatenko G.O.

    2016-06-01

    Full Text Available Purpose: to determine influence of the worked out extra training means’ complex on effectiveness of realization of elite sportsmen’s competition functioning components. Material: in the research 12 fencers participated. The researches were conducted in the morning, against the background of organism’s recreation. Before sportsmen’s duel we applied two types of pre-competition warming up: traditional and experimental. Video recording was fulfilled with video camera Samsung HMX-S15. Results: we calculated volume, effectiveness and efficiency of sportsmen’s actions in fights with different opponents and in different situations of duel. We showed possibility of extra training complexes’ application, oriented on mobilization of workability in the process of direct pre-start preparation of elite sportsmen. Such exercises considered main actions and organism’s typical responses in the process of competition functioning. Conclusions: Consideration of typolical (for fencing organism’s responses and peculiarities of competition functioning structure influence positively on indicators of sportsmen’s competition functioning.

  16. Hypotensive effect and endothelium-dependent vascular action of leaves of Alpinia purpurata (Vieill K. Schum

    Directory of Open Access Journals (Sweden)

    Alessandra Tesch da Silva

    2014-04-01

    Full Text Available The aims of this study were to evaluate the chemical profile, vascular reactivity, and acute hypotensive effect (AHE of the ethanolic extract of leaves of Alpinia purpurata (Vieill K. Schum (EEAP. Its chemical profile was evaluated using HPLC-UV, ICP-OES, and colorimetric quantification of total flavonoids and polyphenols. The vascular reactivity of the extract was determined using the mesenteric bed isolated from WKY. AHE dose-response curves were obtained for both EEAP and inorganic material isolated from AP (IAP in WKY and SHR animals. Cytotoxic and mutagenic safety levels were determined by the micronucleus test. Rutin-like flavonoids were quantified in the EEAP (1.8 ± 0.03%, and the total flavonoid and polyphenol ratios were 4.1 ± 1.8% and 5.1 ± 0.3%, respectively. We observed that the vasodilation action of EEAP was partially mediated by nitric oxide (·NO. The IAP showed the presence of calcium (137.76 ± 4.08 μg mg-1. The EEAP and IAP showed an AHE in WKY and SHR animals. EEAP did not have cytotoxic effects or cause chromosomic alterations. The AHE shown by EEAP could result from its endothelium-dependent vascular action. Rutin-like flavonoids, among other polyphenols, could contribute to these biological activities, and the calcium present in EEAP could act in a synergistic way.

  17. [The effect of blood serum proteins from the seal on the analgetic action of narcotic analgesics].

    Science.gov (United States)

    Aslaniants, Zh K; Melik-Eganov, G R; Evstratov, A V; Ivanov, M P; Batrakov, S G; Korobov, N V; Iasnetsov, V V

    1991-11-01

    The protein fraction isolated from blood of seal, Phoca groenlandica, has been found to produce hyperalgesic effect on rats exposed to thermic or electrocutaneous nociceptive stimulation, but fail to affect writhes provoked by intraperitoneal injection of acetic acid solution on mice. When combined with morphine, the fraction lowered completely its narcotic analgetic action in the above mentioned tests. On the contrary, these same proteins combined with promedol or fentanil enhanced and prolonged analgetic effect of the latter. Tested in vitro the protein showed neither opioid nor anti-opioid activity. Therefore it is reasonable to suppose that neurophysiological activity of the isolated fraction is due to the peptides formed on enzymatic hydrolysis of proteins in vivo rather than these proteins as such. PMID:1687360

  18. Effect of sampling frequency on the measurement of phase-locked action potentials.

    Directory of Open Access Journals (Sweden)

    Go eAshida

    2010-09-01

    Full Text Available Phase-locked spikes in various types of neurons encode temporal information. To quantify the degree of phase-locking, the metric called vector strength (VS has been most widely used. Since VS is derived from spike timing information, error in measurement of spike occurrence should result in errors in VS calculation. In electrophysiological experiments, the timing of an action potential is detected with finite temporal precision, which is determined by the sampling frequency. In order to evaluate the effects of the sampling frequency on the measurement of VS, we derive theoretical upper and lower bounds of VS from spikes collected with finite sampling rates. We next estimate errors in VS assuming random sampling effects, and show that our theoretical calculation agrees with data from electrophysiological recordings in vivo. Our results provide a practical guide for choosing the appropriate sampling frequency in measuring VS.

  19. Wess-Zumino-Witten action and photons from the Chiral Magnetic Effect

    CERN Document Server

    Fukushima, Kenji

    2012-01-01

    We revisit the Chiral Magnetic Effect (CME) using the chiral Lagrangian. We demonstrate that the electric-current formula of the CME is derived immediately from the contact part of the Wess-Zumino-Witten action. This implies that the CME could be, if observed, a signature for the local parity violation, but a direct evidence for neither quark deconfinement nor chiral restoration. We also discuss the reverse Chiral Magnetic Primakoff Effect, i.e. the real photon production through the vertex associated with the CME, which is kinematically possible for space-time inhomogeneous magnetic field and the strong theta angle. We make a semi-quantitative estimate for the photon yield to find that it could be on the observable level as compared to the thermal photon.

  20. Unintended consequences of management actions in salt pond restoration: cascading effects in trophic interactions.

    Directory of Open Access Journals (Sweden)

    John Y Takekawa

    Full Text Available Salt evaporation ponds have played an important role as habitat for migratory waterbirds across the world, however, efforts to restore and manage these habitats to maximize their conservation value has proven to be challenging. For example, salinity reduction has been a goal for restoring and managing former salt evaporation ponds to support waterbirds in the South Bay Salt Pond Restoration Project in San Francisco Bay, California, USA. Here, we describe a case study of unexpected consequences of a low-dissolved oxygen (DO event on trophic interactions in a salt pond system following management actions to reduce salinity concentrations. We document the ramifications of an anoxic event in water quality including salinity, DO, and temperature, and in the response of the biota including prey fish biomass, numerical response by California Gulls (Larus californicus, and chick survival of Forster's Tern (Sterna forsteri. Management actions intended to protect receiving waters resulted in decreased DO concentrations that collapsed to zero for ≥ 4 consecutive days, resulting in an extensive fish kill. DO depletion likely resulted from an algal bloom that arose following transition of the pond system from high to low salinity as respiration and decomposition outpaced photosynthetic production. We measured a ≥ 6-fold increase in biomass of fish dropped on the levee by foraging avian predators compared with weeks prior to and following the low-DO event. California Gulls rapidly responded to the availability of aerobically-stressed and vulnerable fish and increased in abundance by two orders of magnitude. Mark-recapture analysis of 254 Forster's Tern chicks indicated that their survival declined substantially following the increase in gull abundance. Thus, management actions to reduce salinity concentrations resulted in cascading effects in trophic interactions that serves as a cautionary tale illustrating the importance of understanding the interaction

  1. Empowering America's Communities to Prepare for the Effects of Climate Change: Developing Actionable Climate Science Under the President's Climate Action Plan

    Science.gov (United States)

    Duffy, P. B.; Colohan, P.; Driggers, R.; Herring, D.; Laurier, F.; Petes, L.; Ruffo, S.; Tilmes, C.; Venkataraman, B.; Weaver, C. P.

    2014-12-01

    Effective adaptation to impacts of climate change requires best-available information. To be most useful, this information should be easily found, well-documented, and translated into tools that decision-makers use and trust. To meet these needs, the President's Climate Action Plan includes efforts to develop "actionable climate science". The Climate Data Initiative (CDI) leverages the Federal Government's extensive, open data resources to stimulate innovation and private-sector entrepreneurship in support of actions to prepare for climate change. The Initiative forges commitments and partnerships from the private, NGO, academic, and public sectors to create data-driven tools. Open data from Federal agencies to support this innovation is available on Climate.Data.gov, initially focusing on coastal flooding but soon to expand to topics including food, energy, water, energy, transportation, and health. The Climate Resilience Toolkit (CRT) will facilitate access to data-driven resilience tools, services, and best practices, including those accessible through the CDI. The CRT will also include access to training and tutorials, case studies, engagement forums, and other information sources. The Climate Action Plan also calls for a public-private partnership on extreme weather risk, with the goal of generating improved assessments of risk from different types of extreme weather events, using methods and data that are transparent and accessible. Finally, the U.S. Global Change Research Program and associated agencies work to advance the science necessary to inform decisions and sustain assessments. Collectively, these efforts represent increased emphasis across the Federal Government on the importance of information to support climate resilience.

  2. Action Research in Special Education: An Inquiry Approach for Effective Teaching and Learning. Practitioner Inquiry Series

    Science.gov (United States)

    Bruce, Susan M.; Pine, Gerald J.

    2010-01-01

    This is the first book about action research devoted to the complex issues faced by children with disabilities and their teachers. The authors begin by providing the historical and philosophical underpinnings of action research and then present a framework for conducting action research in special education. In addition, they feature four examples…

  3. Effect of shear connectors on local buckling and composite action in steel concrete composite walls

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Kai, E-mail: kai-zh@purdue.edu [School of Civil Engineering, Purdue University, West Lafayette, IN (United States); Varma, Amit H., E-mail: ahvarma@purdue.edu [School of Civil Engineering, Purdue University, West Lafayette, IN (United States); Malushte, Sanjeev R., E-mail: smalusht@bechtel.com [Bechtel Power Corporation, Frederick, MD (United States); Gallocher, Stewart, E-mail: stewart.gallocher@steelbricks.com [Modular Walling Systems Ltd., Glasgow (United Kingdom)

    2014-04-01

    Steel concrete composite (SC) walls are being used for the third generation nuclear power plants, and also being considered for small modular reactors. SC walls consist of thick concrete walls with exterior steel faceplates serving as reinforcement. These steel faceplates are anchored to the concrete infill using shear connectors, for example, headed steel studs. The steel faceplate thickness (t{sub p}) and yield stress (F{sub y}), and the shear connector spacing (s), stiffness (k{sub s}), and strength (Q{sub n}) determine: (a) the level of composite action between the steel plates and the concrete infill, (b) the development length of steel faceplates, and (c) the local buckling of the steel faceplates. Thus, the shear connectors have a significant influence on the behavior of composite SC walls, and should be designed accordingly. This paper presents the effects of shear connector design on the level of composite action and development length of steel faceplates in SC walls. The maximum steel plate slenderness, i.e., ratio of shear connector spacing-to-plate thickness (s/t{sub p}) ratio to prevent local buckling before yielding is also developed based on the existing experimental database and additional numerical analysis.

  4. Enforcement actions and their effectiveness in securities regulation:Empirical evidence from management earnings forecasts

    Institute of Scientific and Technical Information of China (English)

    Yunling Song; Xinwei Ji

    2012-01-01

    Due to resource constraints,securities regulators cannot find or punish all firms that have conducted irregular or even illegal activities(hereafter referred to as fraud).Those who study securities regulations can only find the instances of fraud that have been punished,not those that have not been punished,and it is these unknown cases that would make the best control sample for studies of enforcement action criteria.China’s mandatory management earnings forecasts solve this sampling problem.In the A-share market,firms that have not forecasted as mandated are likely in a position to be punished by securities regulators or are attempting to escape punishment,and their identification allows researchers to build suitable study and control samples when examining securities regulations.Our results indicate that enforcement actions taken by securities regulators are selective.The probability that a firm will be punished for irregular management forecasting is significantly related to proxies for survival rates.Specifically,fraudulent firms with lower return on assets(ROAs) or higher cash flow risk are more likely to be punished.Further analysis shows that selective enforcement of regulations has had little positive effect on the quality of listed firms’ management forecasts.

  5. Functional foods effective for hepatitis C: Identification of oligomeric proanthocyanidin and its action mechanism

    Institute of Scientific and Technical Information of China (English)

    Yo-ichi; Ishida; Masahiko; Takeshita; Hiroaki; Kataoka

    2014-01-01

    Hepatitis C virus(HCV)is a major cause of viral hepatitis and currently infects approximately 170 million people worldwide.An infection by HCV causes high rates of chronic hepatitis(>75%)and progresses to liver cirrhosis and hepatocellular carcinoma ultimately.HCV can be eliminated by a combination of pegylatedα-interferon and the broad-spectrum antiviral drug ribavirin;however,this treatment is still associated with poor efficacy and tolerability and is often accompanied by serious side-effects.While some novel direct-actingantivirals against HCV have been developed recently,high medical costs limit the access to the therapy in cost-sensitive countries.To search for new natural anti-HCV agents,we screened local agricultural products for their suppressive activities against HCV replication using the HCV replicon cell system in vitro.We found a potent inhibitor of HCV RNA expression in the extracts of blueberry leaves and then identified oligomeric proanthocyanidin as the active ingredient.Further investigations into the action mechanism of oligomeric proanthocyanidin suggested that it is an inhibitor of heterogeneous nuclear ribonucleoproteins(hn RNPs)such as hn RNP A2/B1.In this review,we presented an overview of functional foods and ingredients efficient for HCV infection,the chemical structural characteristics of oligomeric proanthocyanidin,and its action mechanism.

  6. Effects of the association of antifungal drugs on the antimicrobial action of endodontic sealers

    Directory of Open Access Journals (Sweden)

    Paulo Henrique WECKWERTH

    2015-01-01

    Full Text Available This in vitro study aimed to determine the susceptibility of oral specimens and ATCC lineages of Candida albicans for five endodontic sealers, which were pure and associated with two antifungal drugs, and to analyze their effect on the physical properties. For this purpose, 30 lineages of C. albicans, collected from the oral cavity of patients assisted at the endodontics clinic of the Universidade Sagrado Coração, were analyzed. Yeasts susceptibility to the sealers was tested by diffusion on agar plates. Physical properties were evaluated according to the ADA specification no. 57. The pure versions of the Sealer 26, AH Plus, Endofill, Fillapex, and Sealapex demonstrated antifungal activity, with Endofill presenting the greatest inhibition zones. All cements, except for Endofill, had their antifungal actions enhanced by addition of ketoconazole and fluconazole (p < 0.05, and the AH Plus presented the best antifungal activity. The addition of antifungal drugs did not interfere with the setting time and flowability of the sealers. It was concluded that the addition of antifungals to endodontic sealers enhanced the antimicrobial action of most cements tested without altering their physical properties.

  7. Effect of shear connectors on local buckling and composite action in steel concrete composite walls

    International Nuclear Information System (INIS)

    Steel concrete composite (SC) walls are being used for the third generation nuclear power plants, and also being considered for small modular reactors. SC walls consist of thick concrete walls with exterior steel faceplates serving as reinforcement. These steel faceplates are anchored to the concrete infill using shear connectors, for example, headed steel studs. The steel faceplate thickness (tp) and yield stress (Fy), and the shear connector spacing (s), stiffness (ks), and strength (Qn) determine: (a) the level of composite action between the steel plates and the concrete infill, (b) the development length of steel faceplates, and (c) the local buckling of the steel faceplates. Thus, the shear connectors have a significant influence on the behavior of composite SC walls, and should be designed accordingly. This paper presents the effects of shear connector design on the level of composite action and development length of steel faceplates in SC walls. The maximum steel plate slenderness, i.e., ratio of shear connector spacing-to-plate thickness (s/tp) ratio to prevent local buckling before yielding is also developed based on the existing experimental database and additional numerical analysis

  8. Differential effects of forward and backward masks on the relationship between perception and action.

    Science.gov (United States)

    Deplancke, A; Madelain, L; Coello, Y

    2016-03-01

    A recent series of experiments has shown that the effects of near-threshold stimuli on perceptual and motor responses are highly dependent on experimental conditions. In particular, motor influences of near-threshold distractors were observed when using low-contrast unmasked stimuli and high-contrast masked stimuli although only the latter affected motor responses in the absence of stimulus awareness. These results are compatible with neurophysiological models of visual masking, suggesting that early neural responses to a visual stimulus can be decomposed in feedforward activations to-and feedback activations from-higher visual areas, correlating respectively with the actual presence of the stimulus and its conscious perception. We tested the compatibility between these neurophysiological models and the behavioural data obtained in near-threshold experiments. We recorded fast reaching movements directed to a highly visible target followed by a report of the presence of a near-threshold distractor presented either at low contrast without mask or at high contrast with a backward or forward mask. Analysis of hand trajectories revealed that deviations toward the distractor were observed in the no-mask condition when the distractor was present and reported, and when it was present but not reported in the backward and forward mask conditions, although the effect was weaker in the latter condition. These data reveal that the presence or absence of perception-action dissociations in behavioural studies are well accounted for by neurophysiological models of visual masking and that behavioural effects of near-threshold distractors cannot result merely from on a dichotomic visual system for perception and action.

  9. Nonlinear effects in infrared action spectroscopy of silicon and vanadium oxide clusters: experiment and kinetic modeling.

    Science.gov (United States)

    Calvo, Florent; Li, Yejun; Kiawi, Denis M; Bakker, Joost M; Parneix, Pascal; Janssens, Ewald

    2015-10-21

    For structural assignment of gas phase compounds, infrared action spectra are usually compared to computed linear absorption spectra. However, action spectroscopy is highly nonlinear owing to the necessary transfer of the excitation energy and its subsequent redistribution leading to statistical ionization or dissociation. Here, we examine by joint experiment and dedicated modeling how such nonlinear effects affect the spectroscopic features in the case of selected inorganic clusters. Vibrational spectra of neutral silicon clusters are recorded by tunable IR-UV two-color ionization while IR spectra for cationic vanadium oxide clusters are obtained by IR multiphoton absorption followed by dissociation of the bare cluster or of its complex with Xe. Our kinetic modeling accounts for vibrational anharmonicities, for the laser interaction through photon absorption and stimulated emission rates, as well as for the relevant ionization or dissociation rates, all based on input parameters from quantum chemical calculations. Comparison of the measured and calculated spectra indicates an overall agreement as far as trends are concerned, except for the photodissociation of the V3O7(+)-Xe messenger complex, for which anharmonicities are too large and poorly captured by the perturbative anharmonic model. In all systems studied, nonlinear effects are essentially manifested by variations in the intensities as well as spectral broadenings. Differences in some band positions originate from inaccuracies of the quantum chemical data rather than specific nonlinear effects. The simulations further yield information on the average number of photons absorbed, which is otherwise unaccessible information: several to several tens of photons need to be absorbed to observe a band through dissociation, while three to five photons can be sufficient for detection of a band via IR-UV ionization. PMID:26208251

  10. Protective action of low-intensity laser radiation relative to the toxic effect of metals (experimental study in vitro)

    Science.gov (United States)

    Dejneka, S. Y.

    1997-12-01

    The study of a possible cytotoxic effect of different doses of low-insensitive laser radiation and protective action of low-intensive laser radiation relative to the toxic effect of metals was carried out by means of the alternative method of investigation in vitro on cell cultura Hela. It was established that the investigated doses of low-intensive laser radiation had not produced any toxic effect on cell culture Hela, so the mentioned doses were not cytotoxic. It was revealed that laser radiation reduced the level of the cytotoxic effect of the studied metal salts on the cell culture, and possessed the protective action against the toxic effect of metals. This action has a clear-cut dose- related character.

  11. Magnetic Back Action Effect of Magnetic Sensors for eLISA/NGO

    Science.gov (United States)

    Mateos, I.; Diaz-Aguiló, M.; Gibert, F.; Lloro, I.; Lobo, A.; Nofrarias, M.; Ramos-Castro, J.

    2013-01-01

    The fluxgate magnetometers used in LISA Pathfinder mission are able to perform very low noise measurements at milli-Hertz frequency, however they need to be kept somehow away from the Test Masses (TMs) due to the quantity of ferromagnetic material contained in the fluxgate's core, which constitutes a potential source of disturbance to the performance. As a result, the estimation of the magnetic field and gradient in the TMs is very problematic, despite the excellent quality of the readout data. The design of a magnetic diagnostic measuring system able to deal with the magnetic constraints for eLISA/NGO will imply the magnetic characterization of the sensors in order to estimate the magnetic back action effect on their environment. The magnetic impact caused by the magnetometers also depends on the noise reduction techniques used in the signal conditioning circuit, which is being studied to develop criteria for the best choice of magnetic sensors for eLISA/NGO.

  12. Two-particle irreducible effective actions versus resummation: analytic properties and self-consistency

    CERN Document Server

    Brown, Michael

    2015-01-01

    Approximations based on two-particle irreducible (2PI) effective actions (also known as $\\Phi$-derivable, Cornwall-Jackiw-Tomboulis or Luttinger-Ward functionals depending on context) have been widely used in condensed matter and non-equilibrium quantum/statistical field theory because this formalism gives a robust, self-consistent, non-perturbative and systematically improvable approach which avoids problems with secular time evolution. The strengths of 2PI approximations are often described in terms of a selective resummation of Feynman diagrams to infinite order. However, the Feynman diagram series is asymptotic and summation is at best a dangerous procedure. Here we show that, at least in the context of a toy model where exact results are available, the true strength of 2PI approximations derives from their self-consistency rather than any resummation. This self-consistency allows truncated 2PI approximations to capture the branch points of physical amplitudes where adjustments of coupling constants can t...

  13. Effective action of heterotic compactification on K3 with non-trivial gauge bundles

    Energy Technology Data Exchange (ETDEWEB)

    Schasny, Martin

    2012-10-15

    In this thesis we study the heterotic string compactified on K3 with non-trivial gauge bundles. We focus on two backgrounds, the well-known standard embedding and abelian line bundles. Using a Kaluza-Klein reduction, the six-dimensional effective action is computed up to terms of order {alpha}'{sup 2} with special attention on the hypermultiplet sector. We compute the moduli dependent couplings of the matter fields and analyze the geometry of the hyperscalar sigma model. Moreover, we prove the consistency with six-dimensional supergravity and derive the appropriate D-term scalar potential. For the line bundle backgrounds we show that the gauge flux stabilizes some geometrical moduli and renders some abelian vector multiplets massive.

  14. String states, loops and effective actions in noncommutative field theory and matrix models

    Science.gov (United States)

    Steinacker, Harold C.

    2016-09-01

    Refining previous work by Iso, Kawai and Kitazawa, we discuss bi-local string states as a tool for loop computations in noncommutative field theory and matrix models. Defined in terms of coherent states, they exhibit the stringy features of noncommutative field theory. This leads to a closed form for the 1-loop effective action in position space, capturing the long-range non-local UV/IR mixing for scalar fields. The formalism applies to generic fuzzy spaces. The non-locality is tamed in the maximally supersymmetric IKKT or IIB model, where it gives rise to supergravity. The linearized supergravity interactions are obtained directly in position space at one loop using string states on generic noncommutative branes.

  15. String states, loops and effective actions in noncommutative field theory and matrix models

    Directory of Open Access Journals (Sweden)

    Harold C. Steinacker

    2016-09-01

    Full Text Available Refining previous work by Iso, Kawai and Kitazawa, we discuss bi-local string states as a tool for loop computations in noncommutative field theory and matrix models. Defined in terms of coherent states, they exhibit the stringy features of noncommutative field theory. This leads to a closed form for the 1-loop effective action in position space, capturing the long-range non-local UV/IR mixing for scalar fields. The formalism applies to generic fuzzy spaces. The non-locality is tamed in the maximally supersymmetric IKKT or IIB model, where it gives rise to supergravity. The linearized supergravity interactions are obtained directly in position space at one loop using string states on generic noncommutative branes.

  16. Nonlinear refractive index measurements and self-action effects in Roselle-Hibiscus Sabdariffa solutions

    Science.gov (United States)

    Henari, F. Z.; Al-Saie, A.

    2006-12-01

    We report the observation of self-action phenomena, such as self-focusing, self-defocusing, self-phase modulation and beam fanning in Roselle-Hibiscus Sabdariffa solutions. This material is found to be a new type of natural nonlinear media, and the nonlinear reflective index coefficient has been determined using a Z-scan technique and by measuring the critical power for the self-trapping effect. Z-scan measurements show that this material has a large negative nonlinear refractive index, n 2 = 1 × 10-4 esu. A comparison between the experimental n 2 values and the calculated thermal value for n 2 suggests that the major contribution to nonlinear response is of thermal origin.

  17. The effect of animation on learning action symbols by individuals with intellectual disabilities.

    Science.gov (United States)

    Fujisawa, Kazuko; Inoue, Tomoyoshi; Yamana, Yuko; Hayashi, Humirhiro

    2011-03-01

    The purpose of the present study was to investigate whether participants with intellectual impairments could benefit from the movement associated with animated pictures while they were learning symbol names. Sixteen school students, whose linguistic-developmental age ranged from 38?91 months, participated in the experiment. They were taught 16 static visual symbols and the corresponding action words (naming task) in two sessions conducted one week apart. In the experimental condition, animation was employed to facilitate comprehension, whereas no animation was used in the control condition. Enhancement of learning was shown in the experimental condition, suggesting that the participants benefited from animated symbols. Furthermore, it was found that the lower the linguistic developmental age, the more effective the animated cue was in learning static visual symbols.

  18. Effective action of heterotic compactification on K3 with non-trivial gauge bundles

    International Nuclear Information System (INIS)

    In this thesis we study the heterotic string compactified on K3 with non-trivial gauge bundles. We focus on two backgrounds, the well-known standard embedding and abelian line bundles. Using a Kaluza-Klein reduction, the six-dimensional effective action is computed up to terms of order α'2 with special attention on the hypermultiplet sector. We compute the moduli dependent couplings of the matter fields and analyze the geometry of the hyperscalar sigma model. Moreover, we prove the consistency with six-dimensional supergravity and derive the appropriate D-term scalar potential. For the line bundle backgrounds we show that the gauge flux stabilizes some geometrical moduli and renders some abelian vector multiplets massive.

  19. String states, loops and effective actions in noncommutative field theory and matrix models

    CERN Document Server

    Steinacker, Harold C

    2016-01-01

    Refining previous work by Iso, Kawai and Kitazawa, we discuss bi-local string states as a tool for loop computations in noncommutative field theory and matrix models. Defined in terms of coherent states, they exhibit the stringy features of noncommutative field theory. This leads to a closed form for the 1-loop effective action in position space, capturing the long-range non-local UV/IR mixing for scalar fields. The formalism applies to generic fuzzy spaces. The non-locality is tamed in the maximally supersymmetric IKKT or IIB model, where it gives rise to supergravity. The linearized supergravity interactions are obtained directly in position space at one loop using string states on generic noncommutative branes.

  20. Antispasmodic Effects and Action Mechanism of Essential Oil of Chrysactinia mexicana A. Gray on Rabbit Ileum

    Directory of Open Access Journals (Sweden)

    Daniel Zavala-Mendoza

    2016-06-01

    Full Text Available The Chrysactinia mexicana A. Gray (C. mexicana plant is used in folk medicine to treat fever and rheumatism; it is used as a diuretic, antispasmodic; and it is used for its aphrodisiac properties. This study investigates the effects of the essential oil of C. mexicana (EOCM on the contractility of rabbit ileum and the mechanisms of action involved. Muscle contractility studies in vitro in an organ bath to evaluate the response to EOCM were performed in the rabbit ileum. EOCM (1–100 µg·mL−1 reduced the amplitude and area under the curve of spontaneous contractions of the ileum. The contractions induced by carbachol 1 µM, potassium chloride (KCl 60 mM or Bay K8644 1 µM were reduced by EOCM (30 µg·mL−1. Apamin 1 µM and charybdotoxin 0.01 µM decreased the inhibition induced by EOCM. The d-cAMP 1 µM decreased the inhibition induced by EOCM. l-NNA 10 µM, Rp-8-Br-PET-cGMPS 1 µM, d,l-propargylglycine 2 mM, or aminooxyacetic acid hemihydrochloride 2 mM did not modify the EOCM effect. In conclusion, EOCM induces an antispasmodic effect and could be used in the treatment of intestinal spasms or diarrhea processes. This effect would be mediated by Ca2+, Ca2+-activated K+ channels and cAMP.

  1. Effects of covert subject actions on percent body fat by air-displacement plethsymography.

    Science.gov (United States)

    Tegenkamp, Michelle H; Clark, R Randall; Schoeller, Dale A; Landry, Greg L

    2011-07-01

    Air-displacement plethysmography (ADP) is used for estimation of body composition, however, some individuals, such as athletes in weight classification sports, may use covert methods during ADP testing to alter their apparent percent body fat. The purpose of this study was to examine the effect of covert subject actions on percent body fat measured by ADP. Subjects underwent body composition analysis in the Bod Pod following the standard procedure using the manufacturer's guidelines. The subjects then underwent 8 more measurements while performing the following intentional manipulations: 4 breathing patterns altering lung volume, foot movement to disrupt air, hand cupping to trap air, and heat and cold exposure before entering the chamber. Increasing and decreasing lung volume during thoracic volume measurement and during body density measurement altered the percent body fat assessment (p < 0.001). High lung volume during thoracic gas measures overestimated fat by 3.7 ± 2.1 percentage points. Lowered lung volume during body volume measures overestimated body fat by an additional 2.2 ± 2.1 percentage points. The heat and cold exposure, tapping, and cupping treatments provided similar estimates of percent body fat when compared with the standard condition. These results demonstrate the subjects were able to covertly change their estimated ADP body composition value by altering breathing when compared with the standard condition. We recommend that sports conditioning coaches, athletic trainers, and technicians administering ADP should be aware of the potential effects of these covert actions. The individual responsible for administering ADP should remain vigilant during testing to detect deliberate altered breathing patterns by athletes in an effort to gain a competitive advantage by manipulating their body composition assessment.

  2. Effect of selected anti-inflammatory drugs on the lethal actions of Leiurus quinquestriatus venom

    Directory of Open Access Journals (Sweden)

    N. A. Abdoon

    2006-01-01

    Full Text Available The cumulative actions of scorpion neurotoxins are complex and may be traced to activation of different ion channels with subsequent release of various transmitters and modulators including inflammatory mediators. This could lead to various pathological manifestations such as acute respiratory distress syndrome (ARDS, systemic inflammatory response syndrome (SIRS, and multiple organ failure (MOF. Several approaches have been advocated to treat the multitude of scorpion-venom-elicited pathological changes. However, few have tried to combat the venom-induced effects on the inflammatory process, which manifest as ARDS, SIDS and MOF. Thus, the aim of this study was to determine the capability of inhibitors of different steps of the inflammatory sequence of events in scorpion envenomation to ameliorate the detrimental action of the venom and prolong survival of mice injected with Leiurus quinquestriatus quinquestriatus (LQQ venom. Animals were divided into groups (n = 10 and given montelukast (10 or 20 mg.kg-1, orally, hydrocortisone (5 or 10 mg.kg-1, intravenously or indomethacin (10 or 20 mg kg-1, intravenously. Then, all animals were subcutaneously injected with either 0.25 or 0.3 mg.kg-1 LQQ venom. Signs and symptoms of envenomation were recorded and survival percentages after 24 hours as well as survival time were determined in each group. To analyze data, we utilized Covariance Wilcoxon survival statistics and survival distribution curves. In general, when compared to venom alone, administration of montelukast (p<0.001, hydrocortisone (p<0.05 and indomethacin (p<0.05 prolonged survival time and increased the percentage of surviving animals per group, with montelukast exhibiting the greatest protecting power. Thus, anti-inflammatory drugs may play an important role in protection against the lethal effects of scorpion venoms.

  3. QED effective action for an O(2)xO(3) symmetric field in the full mass range

    CERN Document Server

    Ahmadiniaz, N; Raya, A; Schubert, C

    2013-01-01

    An interesting class of background field configurations in QED are the O(2)xO(3) symmetric fields. Those backgrounds have some instanton-like properties and yield a one-loop effective action that is highly nontrivial but amenable to numerical calculation, for both scalar and spinor QED. Here we use the recently developed "partial-wave-cutoff method" for a numerical analysis of both effective actions in the full mass range. In particular, at large mass we are able to match the asymptotic behavior of the physically renormalized effective action against the leading two mass levels of the inverse mass (or heat kernel) expansion. At small mass we obtain good numerical results even in the massless case for the appropriately (unphysically) renormalized effective action after the removal of the chiral anomaly term through a small radial cutoff factor. In particular, we show that the effective action after this removal remains finite in the massless limit, which also provides indirect support for M. Fry's hypothesis t...

  4. Infrared divergences and harmonic anomalies in the two-loop superstring effective action

    CERN Document Server

    Pioline, Boris

    2015-01-01

    We analyze the pertubative contributions to the $D^4 R^4$ and $D^6 R^4$ couplings in the low-energy effective action of type II string theory compactified on a torus $T^d$, with particular emphasis on two-loop corrections. In general, it is necessary to introduce an infrared cut-off $\\Lambda$ to separate local interactions from non-local effects due to the exchange of massless states. We identify the degenerations of the genus-two Riemann surface which are responsible for power-like dependence on $\\Lambda$, and give an explicit prescription for extracting the $\\Lambda$-independent effective couplings. These renormalized couplings are then shown to be eigenmodes of the Laplace operator with respect to the torus moduli, up to computable anomalous source terms arising in the presence of logarithmic divergences, in precise agreement with predictions from U-duality. Our results for the two-loop $D^6 R^4$ contribution also probe essential properties of the Kawazumi-Zhang invariant

  5. The action of mimetic peptides on connexins protects fibroblasts from the negative effects of ischemia reperfusion

    Science.gov (United States)

    Glass, Beverley J.; Hu, Rebecca G.; Phillips, Anthony R. J.; Becker, David L.

    2015-01-01

    ABSTRACT Connexins have been proposed as a target for therapeutic treatment of a variety of conditions. The main approaches have been by antisense or small peptides specific against connexins. Some of these peptides enhance communication while others interfere with connexin binding partners or bind to the intracellular and extracellular loops of connexins. Here, we explored the mechanism of action of a connexin mimetic peptide by evaluating its effect on gap junction channels, connexin protein levels and hemichannel activity in fibroblast cells under normal conditions and following ischemia reperfusion injury which elevates Cx43 levels, increases hemichannel activity and causes cell death. Our results showed that the effects of the mimetic peptide were concentration-dependent. High concentrations (100-300 μM) significantly reduced Cx43 protein levels and GJIC within 2 h, while these effects did not appear until 6 h when using lower concentrations (10-30 μM). Cell death can be reduced when hemichannel opening and GJIC were minimised. PMID:26471768

  6. The action of mimetic peptides on connexins protects fibroblasts from the negative effects of ischemia reperfusion

    Directory of Open Access Journals (Sweden)

    Beverley J. Glass

    2015-11-01

    Full Text Available Connexins have been proposed as a target for therapeutic treatment of a variety of conditions. The main approaches have been by antisense or small peptides specific against connexins. Some of these peptides enhance communication while others interfere with connexin binding partners or bind to the intracellular and extracellular loops of connexins. Here, we explored the mechanism of action of a connexin mimetic peptide by evaluating its effect on gap junction channels, connexin protein levels and hemichannel activity in fibroblast cells under normal conditions and following ischemia reperfusion injury which elevates Cx43 levels, increases hemichannel activity and causes cell death. Our results showed that the effects of the mimetic peptide were concentration-dependent. High concentrations (100-300 μM significantly reduced Cx43 protein levels and GJIC within 2 h, while these effects did not appear until 6 h when using lower concentrations (10-30 μM. Cell death can be reduced when hemichannel opening and GJIC were minimised.

  7. Effects of terpineol on the compound action potential of the rat sciatic nerve

    Directory of Open Access Journals (Sweden)

    M.R. Moreira

    2001-10-01

    Full Text Available Terpineol, a volatile terpenoid alcohol of low toxicity, is widely used in the perfumery industry. It is an important chemical constituent of the essential oil of many plants with widespread applications in folk medicine and in aromatherapy. The effects of terpineol on the compound action potential (CAP of rat sciatic nerve were studied. Terpineol induced a dose-dependent blockade of the CAP. At 100 µM, terpineol had no demonstrable effect. At 300 µM terpineol, peak-to-peak amplitude and conduction velocity of CAP were significantly reduced at the end of 180-min exposure of the nerve to the drug, from 3.28 ± 0.22 mV and 33.5 ± 7.05 m/s, respectively, to 1.91 ± 0.51 mV and 26.2 ± 4.55 m/s. At 600 µM, terpineol significantly reduced peak-to-peak amplitude and conduction velocity from 2.97 ± 0.55 mV and 32.8 ± 3.91 m/s to 0.24 ± 0.23 mV and 2.72 ± 2.72 m/s, respectively (N = 5. All these effects developed slowly and were reversible upon 180-min washout.

  8. [NEW MECHANISM OF HYPOGLYCEMIC ACTION OF EMBRYONIC ANTITUMOR MODULATOR MKRTCHYAN BY ACTIVATION OF IT'S MEMBRANOPROTECTIVE EFFECT].

    Science.gov (United States)

    Aghajanova, E

    2015-12-01

    As a new means of prevention and treatment of diabetes can be considered Embryonic antitumor modulator Mkrtchyan (EATM). According to our data on the STZ model of diabetes in rats EATM revealed hypoglycemic effect. Moreover, EATM prevented the development of oxidative stress. It is shown that EATM having immunomodulatory action, realizes its effect by regulating the Nox (NAPH oxidase) system. Inactivation of Nox, including the pancreas, is one of the factors determining the safety of the organ responsible for the development of diabetes. The release of the Nox is increased ex vivo and in the patients with type 1 and 2 diabetes. Mechanism for enhancing of the Nox isoforms release from erythrocyte membranes and blood serum exosomes in the presence of ferriHb in diabetes may be due to destabilizing of the cell membranes. It is established that the glucose at low concentrations bound to isoforms of Nox at the membrane surface due to increasing their stability, and at high concentrations, on the contrary, it lowers their stability. Thus, we have demonstrated a new mechanism of destabilization of cell membranes in diabetes mellitus. Suppression of the release of the pancreas Nox membrane cells in this pathology by means of EATM is perhaps a new mechanism of stabilization of these membranes, which explains the antidiabetic effect of the preparation. PMID:26719557

  9. Unexpected events induce motor slowing via a brain mechanism for action-stopping with global suppressive effects.

    Science.gov (United States)

    Wessel, Jan R; Aron, Adam R

    2013-11-20

    When an unexpected event occurs in everyday life (e.g., a car honking), one experiences a slowing down of ongoing action (e.g., of walking into the street). Motor slowing following unexpected events is a ubiquitous phenomenon, both in laboratory experiments as well as such everyday situations, yet the underlying mechanism is unknown. We hypothesized that unexpected events recruit the same inhibition network in the brain as does complete cancellation of an action (i.e., action-stopping). Using electroencephalography and independent component analysis in humans, we show that a brain signature of successful outright action-stopping also exhibits activity following unexpected events, and more so in blocks with greater motor slowing. Further, using transcranial magnetic stimulation to measure corticospinal excitability, we show that an unexpected event has a global motor suppressive effect, just like outright action-stopping. Thus, unexpected events recruit a common mechanism with outright action-stopping, moreover with global suppressive effects. These findings imply that we can now leverage the considerable extant knowledge of the neural architecture and functional properties of the stopping system to better understand the processing of unexpected events, including perhaps how they induce distraction via global suppression.

  10. Bactericidal Effects and Mechanism of Action of Olanexidine Gluconate, a New Antiseptic.

    Science.gov (United States)

    Hagi, Akifumi; Iwata, Koushi; Nii, Takuya; Nakata, Hikaru; Tsubotani, Yoshie; Inoue, Yasuhide

    2015-08-01

    Olanexidine gluconate [1-(3,4-dichlorobenzyl)-5-octylbiguanide gluconate] (development code OPB-2045G) is a new monobiguanide compound with bactericidal activity. In this study, we assessed its spectrum of bactericidal activity and mechanism of action. The minimal bactericidal concentrations of the compound for 30-, 60-, and 180-s exposures were determined with the microdilution method using a neutralizer against 320 bacterial strains from culture collections and clinical isolates. Based on the results, the estimated bactericidal olanexidine concentrations with 180-s exposures were 869 μg/ml for Gram-positive cocci (155 strains), 109 μg/ml for Gram-positive bacilli (29 strains), and 434 μg/ml for Gram-negative bacteria (136 strains). Olanexidine was active against a wide range of bacteria, especially Gram-positive cocci, including methicillin-resistant Staphylococcus aureus and vancomycin-resistant enterococci, and had a spectrum of bactericidal activity comparable to that of commercial antiseptics, such as chlorhexidine and povidone-iodine. In vitro experiments exploring its mechanism of action indicated that olanexidine (i) interacts with the bacterial surface molecules, such as lipopolysaccharide and lipoteichoic acid, (ii) disrupts the cell membranes of liposomes, which are artificial bacterial membrane models, (iii) enhances the membrane permeability of Escherichia coli, (iv) disrupts the membrane integrity of S. aureus, and (v) denatures proteins at relatively high concentrations (≥160 μg/ml). These results indicate that olanexidine probably binds to the cell membrane, disrupts membrane integrity, and its bacteriostatic and bactericidal effects are caused by irreversible leakage of intracellular components. At relatively high concentrations, olanexidine aggregates cells by denaturing proteins. This mechanism differs slightly from that of a similar biguanide compound, chlorhexidine.

  11. Multinational corporations and health care in the United States and Latin America: strategies, actions, and effects.

    Science.gov (United States)

    Jasso-Aguilar, Rebeca; Waitzkin, Howard; Landwehr, Angela

    2004-01-01

    In this article we analyze the corporate dominance of health care in the United States and the dynamics that have motivated the international expansion of multinational health care corporations, especially to Latin America. We identify the strategies, actions, and effects of multinational corporations in health care delivery and public health policies. Our methods have included systematic bibliographical research and in-depth interviews in the United States, Mexico, and Brazil. Influenced by public policy makers in the United States, such organizations as the World Bank, International Monetary Fund, and World Trade Organization have advocated policies that encourage reduction and privatization of health care and public health services previously provided in the public sector. Multinational managed care organizations have entered managed care markets in several Latin American countries at the same time as they were withdrawing from managed care activities in Medicaid and Medicare within the United States. Corporate strategies have culminated in a marked expansion of corporations' access to social security and related public sector funds for the support of privatized health services. International financial institutions and multinational corporations have influenced reforms that, while favorable to corporate interests, have worsened access to needed services and have strained the remaining public sector institutions. A theoretical approach to these problems emphasizes the falling rate of profit as an economic motivation of corporate actions, silent reform, and the subordination of polity to economy. Praxis to address these problems involves opposition to policies that enhance corporate interests while reducing public sector services, as well as alternative models that emphasize a strengthened public sector

  12. A rapid sound-action association effect in human insular cortex.

    Directory of Open Access Journals (Sweden)

    Isabella Mutschler

    Full Text Available BACKGROUND: Learning to play a musical piece is a prime example of complex sensorimotor learning in humans. Recent studies using electroencephalography (EEG and transcranial magnetic stimulation (TMS indicate that passive listening to melodies previously rehearsed by subjects on a musical instrument evokes differential brain activation as compared with unrehearsed melodies. These changes were already evident after 20-30 minutes of training. The exact brain regions involved in these differential brain responses have not yet been delineated. METHODOLOGY/PRINCIPAL FINDING: Using functional mri (fmri, we investigated subjects who passively listened to simple piano melodies from two conditions: in the 'actively learned melodies' condition subjects learned to play a piece on the piano during a short training session of a maximum of 30 minutes before the fMRI experiment, and in the 'passively learned melodies' condition subjects listened passively to and were thus familiarized with the piece. We found increased fMRI responses to actively compared with passively learned melodies in the left anterior insula, extending to the left fronto-opercular cortex. The area of significant activation overlapped the insular sensorimotor hand area as determined by our meta-analysis of previous functional imaging studies. CONCLUSIONS/SIGNIFICANCE: Our results provide evidence for differential brain responses to action-related sounds after short periods of learning in the human insular cortex. As the hand sensorimotor area of the insular cortex appears to be involved in these responses, re-activation of movement representations stored in the insular sensorimotor cortex may have contributed to the observed effect. The insular cortex may therefore play a role in the initial learning phase of action-perception associations.

  13. Effect of action observation therapy on daily activities and motor recovery in stroke patients

    Directory of Open Access Journals (Sweden)

    Mei-Hong Zhu

    2015-09-01

    Conclusion: Action observation therapy significantly improves upper extremity motor function and performance of activities of daily living, and alleviates upper limb spasticity in patients with stroke.

  14. Effects and mechanisms of action of sildenafil citrate in human chorionic arteries.

    LENUS (Irish Health Repository)

    Maharaj, Chrisen H

    2009-01-01

    OBJECTIVES: Sildenafil citrate, a specific phosphodiesterase-5 inhibitor, is increasingly used for pulmonary hypertension in pregnancy. Sildenafil is also emerging as a potential candidate for the treatment of intra-uterine growth retardation and for premature labor. Its effects in the feto-placental circulation are not known. Our objectives were to determine whether phosphodiesterase-5 is present in the human feto-placental circulation, and to characterize the effects and mechanisms of action of sildenafil citrate in this circulation. STUDY DESIGN: Ex vivo human chorionic plate arterial rings were used in all experiments. The presence of phosphodiesterase-5 in the feto-placental circulation was determined by western blotting and immunohistochemical staining. In a subsequent series of pharmacologic studies, the effects of sildenafil citrate in pre-constricted chorionic plate arterial rings were determined. Additional studies examined the role of cGMP and nitric oxide in mediating the effects of sildenafil. RESULTS: Phosphodiesterase-5 mRNA and protein was demonstrated in human chorionic plate arteries. Immunohistochemistry demonstrated phosphodiesterase-5 within the arterial muscle layer. Sildenafil citrate produced dose dependent vasodilatation at concentrations at and greater than 10 nM. Both the direct cGMP inhibitor methylene blue and the cGMP-dependent protein kinase inhibitor Rp-8-Br-PET-cGMPS significantly attenuated the vasodilation produced by sildenafil citrate. Inhibition of NO production with L-NAME did not attenuate the vasodilator effects of sildenafil. In contrast, sildenafil citrate significantly enhanced the vasodilation produced by the NO donor sodium nitroprusside. CONCLUSION: Phosphodiesterase-5 is present in the feto-placental circulation. Sildenafil citrate vasodilates the feto-placental circulation via a cGMP dependent mechanism involving increased responsiveness to NO.

  15. Derivative expansion of the effective action for quantum electrodynamics in 2+1 and 3+1 dimensions

    International Nuclear Information System (INIS)

    The derivative expansion of the one-loop effective action in QED3 and QED4 (quantum electrodynamics) is considered. The first term in such an expansion is the effective action for a constant electromagnetic field. An explicit expression for the next term containing two derivatives of the field strength Fμν, but exact in the magnitude of the field strength, is obtained. The general results for both fermion and scalar electrodynamics are presented. The cases of pure electric and pure magnetic external fields are considered in detail. The Feynman technique for the perturbative expansion of the one-loop effective action in the number of derivatives is developed. copyright 1999 American Institute of Physics

  16. Effect of hypoxia on specific dynamic action and postprandial cardiovascular physiology in rainbow trout (Oncorhynchus mykiss).

    Science.gov (United States)

    Eliason, Erika J; Farrell, Anthony P

    2014-05-01

    Fish routinely encounter hypoxic environments, which may have detrimental effects on digestion and performance. The present study measured oxygen consumption (MO2), gastrointestinal blood flow (GBF), cardiac output (Vb) and heart rate (f(H)) in rainbow trout Oncorhynchus mykiss at 10°C-11.5°C while exposed to a 1.5-h step-wise hypoxia treatment (80%, 60% and 40% saturation=16.7, 12.6 and 8.4 kPa, respectively), which began 4 h after being fed 1% of their body mass. GBF and f(H) significantly decreased by 41 and 25%-29%, respectively, at the most severe hypoxia step (40% saturation), while MO2 and Vb were maintained throughout the entire hypoxia exposure. Thus, GBF and f(H) were more sensitive to hypoxia than MO2 or Vb in digesting rainbow trout. Subsequent to the hypoxic exposure, the fish were returned to normoxia and monitored for a total of 50h after feeding. While the magnitude of SDA was unaffected, peak postprandial MO2 was reduced by 17%, and the duration of specific dynamic action (SDA) was prolonged by 6h in hypoxia-treated fish when compared to control fish. In conclusion, digestive performance was compromised both during and after the hypoxic exposure, which could lead to negative effects on growth.

  17. Mass sum rule of the effective action on vacua with broken rigid N=1 supersymmetry

    Directory of Open Access Journals (Sweden)

    H. Itoyama

    2015-04-01

    Full Text Available We present an extension of the mass sum rule that applies to renormalizable rigid supersymmetric field theories to the case of the N=1 supersymmetric effective action (the gauged non-linear sigma model consisting of adjoint scalar superfields and vector superfields possessing a Kähler potential, a set of gauge coupling functions (second prepotential derivatives and a superpotential, which respectively set their energy scales. The mass sum rule derived is valid for any vacua, including the (metastable one of broken supersymmetry with the condensates of D-term and/or F-term. We manage to extend these analyses to the cases where superfields in (anti-fundamental representation are present. The supertrace is shown to vanish in those cases where underlying geometry is special Kähler and theory under concern is anomaly free. Simple phenomenological application is given, providing an upper bound for gaugino masses. We discuss that the effects of the D and/or F condensates can be represented as a set of soft breaking terms with their strengths predicted by the scales.

  18. Effects of melatonin on pethidine-induced physical dependence and its antioxidative action

    Institute of Scientific and Technical Information of China (English)

    LI Shu-hui; LI Xiao-hui

    2008-01-01

    Objective To study the effects of melatonin on pethidine-induced physical dependence and its antioxidative action. Methods A trauma-pain model was established in Wistar rats by combining right limb amputation with 50 ℃ tail-flick test. The contents of MDA and the activity of the total superoxide dismutase(SOD) in the brain tissue of trauma-pain rats were detected by thiobarbituric acid method and the xanthine oxidase method. A physical dependence model in mice was reproduced by subcutaneous injection of pethidine and the withdrawal syndromes were induced by intraperitoneal injection of naloxone. Results The contents of MDA enhanced, but the activity of SOD decreased greatly in brain tissues postinjury in rats. Melatonin (30, 60,120 mg·kg-1) i. p. reduced the contents of MDA and enhanced the activity of SOD dose-depen-dently. Melatonin alone showed no withdrawal syndrome when it was given until the dosage of 840 mg· kg-1. Moreover, Melatonin (5, 15, 20 mg·kg-1)obviously inhibited the withdrawal jumpings of mice in pethidine-treated groups dose-dependently (P<0.01 ), the jumping rates of mice were decreased 61.4%, 72.8 %, 84.8 %, respectively. Conclusions The present results indicated that melatonin has good antioxidatire effects on the trauma rats. In addiction, melatonin might inhibit withdrawal syndromes in pethidine-dependent mice.

  19. Biological actions of silver nanoparticles embedded in titanium controlled by micro-galvanic effects.

    Science.gov (United States)

    Cao, Huiliang; Liu, Xuanyong; Meng, Fanhao; Chu, Paul K

    2011-01-01

    Titanium embedded with silver nanoparticles (Ag NPs) using a single step silver plasma immersion ion implantation (Ag-PIII) demonstrate micro-galvanic effects that give rise to both controlled antibacterial activity and excellent compatibility with osteoblasts. Scanning electron microscopy (SEM) shows that nanoparticles with average sizes of about 5 nm and 8 nm are formed homogeneously on the titanium surface after undergoing Ag-PIII for 0.5 h and 1 h, respectively. Transmission electron microscopy (TEM) and X-ray photoelectron spectroscopy (XPS) indicate that those nanoparticles are metallic silver produced on and underneath the titanium surface via a local nucleation process from the solid solution of α-Ti(Ag). The Ag-PIII samples inhibit the growth of both Staphylococcus aureus and Escherichia coli while enhancing proliferation of the osteoblast-like cell line MG63. Electrochemical polarization and Zeta potential measurements demonstrate that the low surface toxicity and good cytocompatibility are related to the micro-galvanic effect between the Ag NPs and titanium matrix. Our results show that the physico-chemical properties of the Ag NPs are important in the control of the cytotoxicity and this study opens a new window for the design of nanostructured surfaces on which the biological actions of the Ag NPs can be accurately tailored.

  20. Two-particle irreducible effective actions versus resummation: Analytic properties and self-consistency

    Directory of Open Access Journals (Sweden)

    Michael Brown

    2015-11-01

    Full Text Available Approximations based on two-particle irreducible (2PI effective actions (also known as Φ-derivable, Cornwall–Jackiw–Tomboulis or Luttinger–Ward functionals depending on context have been widely used in condensed matter and non-equilibrium quantum/statistical field theory because this formalism gives a robust, self-consistent, non-perturbative and systematically improvable approach which avoids problems with secular time evolution. The strengths of 2PI approximations are often described in terms of a selective resummation of Feynman diagrams to infinite order. However, the Feynman diagram series is asymptotic and summation is at best a dangerous procedure. Here we show that, at least in the context of a toy model where exact results are available, the true strength of 2PI approximations derives from their self-consistency rather than any resummation. This self-consistency allows truncated 2PI approximations to capture the branch points of physical amplitudes where adjustments of coupling constants can trigger an instability of the vacuum. This, in effect, turns Dyson's argument for the failure of perturbation theory on its head. As a result we find that 2PI approximations perform better than Padé approximation and are competitive with Borel–Padé resummation. Finally, we introduce a hybrid 2PI–Padé method.

  1. Modulatory Effects and Action Mechanisms of Tryptanthrin on Murine Myeloid Leukemia Cells

    Institute of Scientific and Technical Information of China (English)

    Hoi-Ling Chan; Hon-Yan Yip; Nai-Ki Mak; Kwok-Nam Leung

    2009-01-01

    Leukemia is the disorder of hematopoietic cell development and is characterized by an uncoupling of cell proliferation and differentiation. There is a pressing need for the development of novel tactics for leukemia therapy as conventional treatments often have severe adverse side effects. Tryptanthrin (6,12-dihydro-6,12-dioxoindolo-(2,1-b)-quinazoline) is a naturally-occurring, weakly basic alkaloid isolated from the dried roots of medicinal indigo plants (Ban-Lan-Gen). It has been reported to have various biological and pharmacological activities, including anti-microbial, anti-inflammatory, immunomodulatory and anti-tumor effects. However, its modulatory effects and action mechanisms on myeloid cells remain poorly understood. In this study, tryptanthrin was shown to suppress the proliferation of the murine myeloid leukemia WEHI-3B JCS cells in a dose- and time-dependent manner. It also significantly reduced the growth of WEHI-3B JCS cells in vivo in syngeneic BALB/c mice. However, it exhibited no significant direct cytotoxicity on normal murine peritoneal macrophages. Flow cytometric analysis showed an obvious cell cycle arrest of the tryptanthrin-treated WEHI-3B JCS cells at the G0/G1 phase. The expression of cyclin D2,D3, Cdk 2, 4 and 6 genes in WEHI-3B JCS cells was found to be down-regulated at 24 h as measured by RT-PCR. Morphological and functional studies revealed that tryptanthrin could induce differentiation in WEHI-3B JCS cells, as shown by the increases in vacuolation, cellular granularity and NBT-reducing activity in tryptanthrin-treated cells. Collectively, our findings suggest that tryptanthrin might exert its anti-tumor effect on the murine myelomonocytic leukemia WEHI-3B JCS cells by causing cell cycle arrest and by triggering cell differentiation. Cellular & Molecular Immunology. 2009;6(5):335-342.

  2. Effects of Brief Imitative Experience on EEG Desynchronization during Action Observation

    Science.gov (United States)

    Marshall, Peter J.; Bouquet, Cedric A.; Shipley, Thomas F.; Young, Thomas

    2009-01-01

    There is a good deal of evidence that observing the actions of other people is associated with activation of the observer's motor system, which may reflect involvement of the mirror neuron system (MNS) in certain aspects of action processing in humans. Furthermore, variation in the extent of this activation appears to be partly dependent on…

  3. Naming Action in Japanese: Effects of Semantic Similarity and Grammatical Class

    Science.gov (United States)

    Iwasaki, Noriko; Vinson, David P.; Vigliocco, Gabriella; Watanabe, Masumi; Arciuli, Joanne

    2008-01-01

    This study investigated whether the semantic similarity and grammatical class of distracter words affects the naming of pictured actions (verbs) in Japanese. Three experiments used the picture-word interference paradigm with participants naming picturable actions while ignoring distracters. In all three experiments, we manipulated the semantic…

  4. Symmetry improvement of 3PI effective actions for O (N ) scalar field theory

    Science.gov (United States)

    Brown, Michael J.; Whittingham, Ian B.

    2015-04-01

    N-particle irreducible effective actions (nPIEA) are a powerful tool for extracting nonperturbative and nonequilibrium physics from quantum field theories. Unfortunately, practical truncations of nPIEA can unphysically violate symmetries. Pilaftsis and Teresi (PT) addressed this by introducing a "symmetry improvement" scheme in the context of the 2PIEA for an O (2) scalar theory, ensuring that the Goldstone boson is massless in the broken symmetry phase [A. Pilaftsis and D. Teresi, Nucl. Phys. B874, 594 (2013)]. We extend this idea by introducing a symmetry improved 3PIEA for O (N ) theories, for which the basic variables are the one-, two- and three-point correlation functions. This requires the imposition of a Ward identity involving the three-point function. We find that the method leads to an infinity of physically distinct schemes, though a field theoretic analogue of d'Alembert's principle is used to single out a unique scheme. The standard equivalence hierarchy of nPIEA no longer holds with symmetry improvement, and we investigate the difference between the symmetry improved 3PIEA and 2PIEA. We present renormalized equations of motion and counterterms for two- and three-loop truncations of the effective action, though we leave their numerical solution to future work. We solve the Hartree-Fock approximation and find that our method achieves a middle ground between the unimproved 2PIEA and PT methods. The phase transition predicted by our method is weakly first order and the Goldstone theorem is satisfied, while the PT method correctly predicts a second-order phase transition. In contrast, the unimproved 2PIEA predicts a strong first-order transition with large violations of the Goldstone theorem. We also show that, in contrast to PT, the two-loop truncation of the symmetry improved 3PIEA does not predict the correct Higgs decay rate, although the three-loop truncation does, at least to leading order. These results suggest that symmetry improvement should not

  5. Effect and Functional Mechanism of the Action of Exogenous Gibberellin on Flowering of Peach

    Institute of Scientific and Technical Information of China (English)

    AN Li-jun; JIN Liang; YANG Chun-qin; LI Tian-hong

    2008-01-01

    This study was conducted to assess the effect of gibberellin and its possible mechanism of action on peach flower formation. At flower induction, 100 mg L-1 of gibberellic acid 3 (GA3) was sprayed on the leaves of peach [Prunus persica (L.) Batsch.] cv. Bayuecui. Using anatomy, immunohistochemistry, and semi-quantitation, the in situ distribution of GAs and the expression of the key genes involved in peach flower formation in the apical meristem were studied during flowering differentiation. The results showed that induction of flowering in the Bayuecui peach occurred prior to 10 July in Beijing, China. Flower induction and further differentiation of the peach flower organs were significantly inhibited by leaf-spraying of GA3 at a concentration of 100 mg L-1 during the induction stage. The flowering rate was only 11.67% after treatment. The distribution of GA1 in the apical meristem varied during the process of flower bud differentiation. From 13 June to 25 July, the GA1 signal from control plants was detected mainly in the vascular bundles at the base of the flower buds. No GA1 signal was detected in the apical meristem. After treatment with GA3, the distribution was similar to that of the control from 13 June to 3 July. On 13 July, a GA1 signal was detected in the apical meristem accompanied by an increase in the GA1 signal in the vascular bundles at the base of the flower buds. The GAI signal weakened significantly in both the vascular bundles and the apical meristem on 25 July. The expression of the genes PpLEAFY and MADS6 in flower buds could be detected only on 10 October in the GA3-treated plants. The critical period for flower induction of Bayuecui peach in Beijing was in early July, during which time, leaf-spraying with 100 mg L-1 GA3 could effectively inhibit flower induction and further differentiation of the flower buds. GA1 in the gibberellin family was the suppressor for flower induction in peach. Its action was affected by the stage of flower bud

  6. The effect of behavioral preferences on skill acquisition in determining unspecified, suitable action patterns to control humanoid robots.

    Science.gov (United States)

    Takayama, Taiki; Watanabe, Tetsuyou

    2015-08-01

    This research investigated the effect of behavioral preferences on learning efficiency when attempting to determine unspecified, but suitable action sequences for unfamiliar tasks. The goal of this research was to develop a skill acquisition support system for the elderly to aid them in using unfamiliar IT products, particularly those of welfare systems. Here, behavioral preference is defined as the type of action sequences that people would prefer to adopt for completing unfamiliar tasks. To achieve this goal, this research investigated the action sequences of participants when they attempt to control the posture of an unfamiliar humanoid robot with an unfamiliar controller. The participants were assigned the task of making the humanoid stand on one foot. Machine-learning-based methods were presented for analyzing the behavioral preferences. The analysis results indicate that participants having behavioral preferences of adopting random action sequences can complete the task in a much shorter time, compared to participants having a behavioral preference of adopting action sequences similar to those of previous actions. PMID:26738048

  7. Clinical Effect and Action Mechanism of Weicao Capsule(威草胶囊)In Treating Gout

    Institute of Scientific and Technical Information of China (English)

    SONG En-feng; XIANG Qiong; REN Kai-ming; HU Jia-cai; WU Fan; GONG Mei-fang; ZHANG Hong; BI Hui-min

    2008-01-01

    Obiective:To study the therapeutic effect of Weicao Capsule(威草胶囊,WCC)on gout.Methods:Two hundred gout patients were assigned to two groups.The treated group was groups were given the respective treatments orally 3 times a day,2 capsules each time with 2 weeks as one course and all patients received 2 successive courses of treatment.Changes of blood β2-microglobulin(β2-M),hemoglobin(Hb),24 h urinary protein(24 h UP),pH value of urine and blood uric acid(BUA)as well as kidney function were observed.Results:After treatment,IeveI of β2-M got lowered significantly,Hb and 24 h UP,blood urea nitrogen,serum creatinine and the clearance rate of creatinine,as well as blood lipids all improved obviously in the treated group(all P<0.01),while these parameters remained unchanged in the control group (P>0.05).The pH value of urine was improved in both groups showing an insignificant difference between them(P>0.05).BUA was decreased in both groups with a decrease to a larger extent in the treated group(P<0.01).The total effective rate was 87% in the treated group,which was superior to that in the control group(62%,P<0.05).Conclusion:WCC has a favorable therapeutic effect on gout and its mechanism of action for improving renal function and reducing urinary protein could be related with the lowering of blood β2-M,BUA and lipids.

  8. Effects of estragole on the compound action potential of the rat sciatic nerve

    Directory of Open Access Journals (Sweden)

    J.H. Leal-Cardoso

    2004-08-01

    Full Text Available Estragole, a relatively nontoxic terpenoid ether, is an important constituent of many essential oils with widespread applications in folk medicine and aromatherapy and known to have potent local anesthetic activity. We investigated the effects of estragole on the compound action potential (CAP of the rat sciatic nerve. The experiments were carried out on sciatic nerves dissected from Wistar rats. Nerves, mounted in a moist chamber, were stimulated at a frequency of 0.2 Hz, with electric pulses of 50-100-µs duration at 10-20 V, and evoked CAP were monitored on an oscilloscope and recorded on a computer. CAP control parameters were: peak-to-peak amplitude (PPA, 9.9 ± 0.55 mV (N = 15, conduction velocity, 92.2 ± 4.36 m/s (N = 15, chronaxy, 45.6 ± 3.74 µs (N = 5, and rheobase, 3.9 ± 0.78 V (N = 5. Estragole induced a dose-dependent blockade of the CAP. At 0.6 mM, estragole had no demonstrable effect. At 2.0 and 6.0 mM estragole, PPA was significantly reduced at the end of 180-min exposure of the nerve to the drug to 85.6 ± 3.96 and 13.04 ± 1.80% of control, respectively. At 4.0 mM, estragole significantly altered PPA, conduction velocity, chronaxy, and rheobase (P <= 0.05, ANOVA; N = 5 to 49.3 ± 6.21 and 77.7 ± 3.84, 125.9 ± 10.43 and 116.7 ± 4.59%, of control, respectively. All of these effects developed slowly and were reversible upon a 300-min wash-out. The data show that estragole dose-dependently blocks nerve excitability.

  9. Effects of the bleaching sequence on the optical brighteners action in eucalyptus kraft pulp

    Directory of Open Access Journals (Sweden)

    Mauro Manfredi

    2014-06-01

    Full Text Available During the bleaching process the pulp is treated with chemical reagents that can be retained in the pulp and interfere in the action of the optical brighteners. Different bleaching sequences can produce pulps at the same brightness but with different potential to whiteness increase when treated with optical brighteners. The objective of this study was to evaluate the influence of the bleaching sequence on the efficiency of disulphonated and tetrasulphonated optical brighteners. Eucalyptus kraft pulp was bleached using four different bleaching sequences. For each pulp three brightness targets were aimeds. For each bleaching sequence mathematical model was generated for predicting the final pulp whiteness according to the initial brightness and the optical brightener charge applied. The presence of organochlorine residues in the pulp reduced the effectiveness of the optical brighteners. Therefore, bleaching sequences that use low chlorine dioxide charge favors for greater gains in whiteness with the application of optical brighteners. The replacement of the final chlorine dioxide bleaching stage with a hydrogen peroxide one in the sequence increased the efficiency of the optical brightening agents.

  10. Immunomodulatory effects of fluoxetine: A new potential pharmacological action for a classic antidepressant drug?

    Science.gov (United States)

    Di Rosso, María Emilia; Palumbo, María Laura; Genaro, Ana María

    2016-07-01

    Selective serotonin reuptake inhibitors are frequently used antidepressants. In particular, fluoxetine is usually chosen for the treatment of the symptoms of depression, obsessive-compulsive, panic attack and bulimia nervosa. Antidepressant therapy has been associated with immune dysfunction. However, there is contradictory evidence about the effect of fluoxetine on the immune system. Experimental findings indicate that lymphocytes express the serotonin transporter. Moreover it has been shown that fluoxetine is able to modulate the immune function through a serotonin-dependent pathway and through a novel independent mechanism. In addition, several studies have shown that fluoxetine can alter tumor cell viability. Thus, it was recently demonstrated in vivo that chronic fluoxetine treatment inhibits tumor growth by increasing antitumor T-cell activity. Here we briefly review some of the literature referring to how fluoxetine is able to modify, for better or worse, the functionality of the immune system. These results of our analysis point to the relevance of the novel pharmacological action of this drug as an immunomodulator helping to treat several pathologies in which immune deficiency and/or deregulation is present. PMID:26644208

  11. Effect of meal size on the specific dynamic action of the juvenile snakehead (Channa argus).

    Science.gov (United States)

    Wang, Qianqian; Wang, Wen; Huang, Qingda; Zhang, Yurong; Luo, Yiping

    2012-04-01

    The effect of meal size on the specific dynamic action (SDA) of the juvenile snakehead (Channa argus) was assessed at 25 °C. The fish were fed with test diets at meal sizes of 0.5, 1, 2, 3, 4, and 5% body mass and the postprandial oxygen consumption rate was determined at 1-h intervals until it returned to the pre-prandial level. The peak metabolic rate increased from 237.4 to 283.2 mg O(2) kg(-1) h(-1) as the relative meal size increased from 0.5% to 3% and leveled off at 4% and 5%. Factorial metabolic scope increased from 1.53 to 1.99 and SDA duration increased from 11.7 to 32.3h as the relative meal size increased from 0.5% to 5%. The relationship between SDA duration (D) and relative meal size (M) was described as: D=4.28 M+10.62 (r(2)=0.752, Psnakehead may adopt different feeding strategies when taking in different amounts of food.

  12. The effective action of D6-branes in mathcal{N} = 1 type IIA orientifolds

    Science.gov (United States)

    Kerstan, Max; Weigand, Timo

    2011-06-01

    We use a Kaluza-Klein reduction to compute the low-energy effective action for the massless modes of a spacetime-filling D6-brane wrapped on a special Lagrangian 3-cycle of a type IIA Calabi-Yau orientifold. The modifications to the characteristic data of the mathcal{N} = 1 bulk orientifold theory in the presence of a D6-brane are analysed by studying the underlying Type IIA supergravity coupled to the brane world volume in the democratic formulation and performing a detailed dualisation procedure. The mathcal{N} = 1 chiralcoordinates are found to be in agreement with expectations from mirror symmetry. We work out the Kähler potential for the chiral superfields as well as the gauge kinetic functions for the bulk and the brane gauge multiplets including the kinetic mixing between the two. The scalar potential resulting from the dualisation procedure can be formally interpreted in terms of a superpotential. Finally, the gauging of the Peccei-Quinn shift symmetries of the complex structure multiplets reproduces the D-term potential enforcing the calibration condition for special Lagrangian 3-cycles.

  13. The effective action of D6-branes in N=1 type IIA orientifolds

    CERN Document Server

    Kerstan, Max

    2011-01-01

    We use a Kaluza-Klein reduction to compute the low-energy effective action for the massless modes of a spacetime-filling D6-brane wrapped on a special Lagrangian 3-cycle of a type IIA Calabi-Yau orientifold. The modifications to the characteristic data of the N=1 bulk orientifold theory in the presence of a D6-brane are analysed by studying the underlying Type IIA supergravity coupled to the brane worldvolume in the democratic formulation and performing a detailed dualisation procedure. The N=1 chiral coordinates are found to be in agreement with expectations from mirror symmetry. We work out the Kahler potential for the chiral superfields as well as the gauge kinetic functions for the bulk and the brane gauge multiplets including the kinetic mixing between the two. The scalar potential resulting from the dualisation procedure can be formally interpreted in terms of a superpotential. Finally, the gauging of the Peccei-Quinn shift symmetries of the complex structure multiplets reproduces the D-term potential e...

  14. Is India's policy framework geared for effective action on avoidable blindness from diabetes?

    Directory of Open Access Journals (Sweden)

    Shivani M Gaiha

    2016-01-01

    Full Text Available Background: The growing burden of avoidable blindness caused by diabetic retinopathy (DR needs an effective and holistic policy that reflects mechanisms for early detection and treatment of DR to reduce the risk of blindness. Materials and Methods: We performed a comprehensive health policy review to highlight the existing systemic issues that enable policy translation and to assess whether India's policy architecture is geared to address the mounting challenge of DR. We used a keyword-based Internet search for documents available in the last 15 years. Two reviewers independently assessed retrieved policies and extracted contextual and program-oriented information and components delineated in national policy documents. Using a “descriptive analytical” method, the results were collated and summarized as per themes to present status quo, gaps, and recommendations for the future. Results: Lack of focus on building sustainable synergies that require well laid out mechanisms for collaboration within and outside the health sector and poor convergence between national health programs appears to be the weakest links across policy documents. Conclusions: To reasonably address the issues of consistency, comprehensiveness, clarity, context, connectedness, and sustainability, policies will have to rely more strongly on evidence from operational research to support decisions. There is a need to involve multiple stakeholders from multiple sectors, recognize contributions from not-for-profit sector and private health service providers, and finally bring about a nuanced holistic perspective that has a voice with implementable multiple sector actions.

  15. Conservation Without Borders: Building Communication and Action Across Disciplinary Boundaries for Effective Conservation

    Science.gov (United States)

    Margles, Shawn W.; Peterson, Richard B.; Ervin, Jamison; Kaplin, Beth A.

    2010-01-01

    Interdisciplinary approaches to conservation research and environmental management continue to garner interest among practitioners, academics, and students. Yet, cases of practitioners and researchers from different disciplines successfully working in concert towards an integrated conservation approach are rare. What is preventing practitioners of multiple disciplines from harmoniously working together? Why are practitioners and academics struggling to apply their graduate training to real world conservation? What is preventing the benefits of cooperation and partnerships between different disciplines addressing conservation from being realized? This special issue “Conservation without Borders: Building Communication and Action across Disciplinary Boundaries for Effective Conservation” asks readers to consider the numerous interpretations and implications of the phrase “Conservation without Borders” and to reflect on how different academic and disciplinary lenses can contribute to a more integrated approach to tackling conservation challenges. The articles that comprise this special issue offer readers insights into the ways in which different disciplines view conservation work and interdisciplinary approaches to environmental problems. Bringing these perspectives and approaches together in one place is a step towards improving communication across disciplines for the purpose of achieving more successful biodiversity conservation.

  16. Effective action approach to cosmological perturbations in dark energy and modified gravity

    International Nuclear Information System (INIS)

    In light of upcoming observations modelling perturbations in dark energy and modified gravity models has become an important topic of research. We develop an effective action to construct the components of the perturbed dark energy momentum tensor which appears in the perturbed generalized gravitational field equations, δGμν = 8πGδTμν+δUμν for linearized perturbations. Our method does not require knowledge of the Lagrangian density of the dark sector to be provided, only its field content. The method is based on the fact that it is only necessary to specify the perturbed Lagrangian to quadratic order and couples this with the assumption of global statistical isotropy of spatial sections to show that the model can be specified completely in terms of a finite number of background dependent functions. We present our formalism in a coordinate independent fashion and provide explicit formulae for the perturbed conservation equation and the components of δUμν for two explicit generic examples: (i) the dark sector does not contain extra fields, L = L(gμν) and (ii) the dark sector contains a scalar field and its first derivative L = L(gμν,φ,∇μφ). We discuss how the formalism can be applied to modified gravity models containing derivatives of the metric, curvature tensors, higher derivatives of the scalar fields and vector fields

  17. Symmetry improvement of 3PI effective actions for O(N) scalar field theory

    CERN Document Server

    Brown, Michael J

    2015-01-01

    [Abridged] n-Particle Irreducible Effective Actions ($n$PIEA) are a powerful tool for extracting non-perturbative and non-equilibrium physics from quantum field theories. Unfortunately, practical truncations of $n$PIEA can unphysically violate symmetries. Pilaftsis and Teresi (PT) addressed this by introducing a "symmetry improvement" scheme in the context of the 2PIEA for an O(2) scalar theory, ensuring that the Goldstone boson is massless in the broken symmetry phase [A. Pilaftsis and D. Teresi, Nuc.Phys. B 874, 2 (2013), pp. 594--619]. We extend this by introducing a symmetry improved 3PIEA for O(N) theories, for which the basic variables are the 1-, 2- and 3-point correlation functions. This requires the imposition of a Ward identity involving the 3-point function. The method leads to an infinity of physically distinct schemes, though an analogue of d'Alembert's principle is used to single out a unique scheme. The standard equivalence hierarchy of $n$PIEA no longer holds with symmetry improvement and we i...

  18. Effects of Action Video Game on Attention Distribution: A Cognitive Study

    Science.gov (United States)

    Zhang, Xuemin; Yan, Bin; Shu, Hua

    Based on the previous researches, Flanker compatibility effect paradigm was applied to explore the degree where people process the visual information presented on to-be-ignored locations. In present study, this paradigm was used to investigate attention distribution of Video Game Players (VGPs) and Non Video Game Players (NVGPs). The results suggested, under low perceptual load, VGPs tried to focus their attention on the task at-hand whereas the NVGPs tried to explore the adjacent locations with the left-over resources from the research task; however, under high perceptual load, the players would process the visual information at the adjacent locations of the target with the left-over resources, because they had comparatively greater attention capability, whereas the non-players focused their attention on the target locations to finish the search task. To conclude, the present study suggested that action video game play could not only enhance the attention capacity but also cause a different way of attention distribution in different perceptual load situations.

  19. COST 271 Action - Effects of the upper atmosphere on terrestrial and Earth-space communications: introduction

    Directory of Open Access Journals (Sweden)

    L. R. Cander

    2004-06-01

    Full Text Available The COST 271 ActionEffects of the Upper Atmosphere on Terrestrial and Earth-space Communications » within the European ionospheric community has the objectives, embodied in the Memorandum of Understanding (MoU: to study the influence of upper atmospheric conditions on terrestrial and Earth-space communications, to develop methods and techniques to improve ionospheric models over Europe for telecommunication and navigation applications and to transfer the results to the appropriate Radiocommunication Study Groups of the International Telecommunication Union (ITU-R and other national and international organizations dealing with the modern communication systems. This introductory paper summarises briefly the background and historical context of COST 271 and outlines the main objectives, working methods and structure. It also lists the participating countries and institutions, the Management Committee (MC Meetings, Workshops and Short-term Scientific Missions. In addition, the paper discusses the dissemination of the results and the collaboration among the participating institutions and researchers, before outlining the content of the Final Report.

  20. Effects of diphosphonic acid on ilmenorutile collecting property and research of action mechanism

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    The effects of several collectors and their dosage on pure ilmenorutile at different pH values were studied and the collecting strength of several representative collectors was investigated. The experimental results indicate that diphosphonic acid is a good collector for ilmenorutile and the recovery of ilmenorutile ranges from 90.87% to 91.70% when the pulp pH value is 2.0-4.0 and the dosage is 75mg/L. Thesequence of collecting ability for several collectors is as follows: diphosphonic acid > TF279 > cyclic alkyl hydroximic acid > benzyl arsenic acid > salicylic hydroximic acid > alkyl hydroximic acid. Meanwhile, IAS (infrared absorption spectrum) and XPS (X-ray photoelectron spectroscopy) were used to detect and analyze the action mechanism of diphosphonic acid on ilmenorutile. IAS results showed that the characterid between wave numeber and cm, and diphosphonic acid had adsorbed on the surface of ilmenorutile. XPS results indicated that the binding energy of P2P peak of ilmenorutile had changed 0.45eV after treated by diphosphonic acid. This proves that the adsorption is mainly chemical adsorption.

  1. Effective lattice action for the configurations smeared by the Wilson flow

    CERN Document Server

    Kagimura, Aya; Yamamura, Ryo

    2015-01-01

    We investigate a trajectory for the Wilson flow in the theory space. For this purpose, we determine the coefficient of the plaquette and rectangular terms in the action for the configurations defined by the solution of the Wilson flow. The demon method regarded as one of the inverse Monte Carlo methods is used for the determination of them. Starting from the conventional Wilson plaquette action of quenched QCD, we find that the coefficient of the plaquette grows while that of the rectangular tends to negative with the development of the flow as the known improved actions. We also find that the trajectory forms a straight line in the two-coupling theory space.

  2. Intracellular recordings of action potentials by an extracellular nanoscale field-effect transistor

    Science.gov (United States)

    Duan, Xiaojie; Gao, Ruixuan; Xie, Ping; Cohen-Karni, Tzahi; Qing, Quan; Choe, Hwan Sung; Tian, Bozhi; Jiang, Xiaocheng; Lieber, Charles M.

    2012-03-01

    The ability to make electrical measurements inside cells has led to many important advances in electrophysiology. The patch clamp technique, in which a glass micropipette filled with electrolyte is inserted into a cell, offers both high signal-to-noise ratio and temporal resolution. Ideally, the micropipette should be as small as possible to increase the spatial resolution and reduce the invasiveness of the measurement, but the overall performance of the technique depends on the impedance of the interface between the micropipette and the cell interior, which limits how small the micropipette can be. Techniques that involve inserting metal or carbon microelectrodes into cells are subject to similar constraints. Field-effect transistors (FETs) can also record electric potentials inside cells, and because their performance does not depend on impedance, they can be made much smaller than micropipettes and microelectrodes. Moreover, FET arrays are better suited for multiplexed measurements. Previously, we have demonstrated FET-based intracellular recording with kinked nanowire structures, but the kink configuration and device design places limits on the probe size and the potential for multiplexing. Here, we report a new approach in which a SiO2 nanotube is synthetically integrated on top of a nanoscale FET. This nanotube penetrates the cell membrane, bringing the cell cytosol into contact with the FET, which is then able to record the intracellular transmembrane potential. Simulations show that the bandwidth of this branched intracellular nanotube FET (BIT-FET) is high enough for it to record fast action potentials even when the nanotube diameter is decreased to 3 nm, a length scale well below that accessible with other methods. Studies of cardiomyocyte cells demonstrate that when phospholipid-modified BIT-FETs are brought close to cells, the nanotubes can spontaneously penetrate the cell membrane to allow the full-amplitude intracellular action potential to be

  3. One-loop and D-instanton corrections to the effective action of open string models

    Energy Technology Data Exchange (ETDEWEB)

    Schmidt-Sommerfeld, Maximilian

    2009-07-02

    Methods for the calculation of certain corrections to effective actions, which comprehend the low-energy physics of string compactifications with open strings, are explained. First the shape of such actions is describes and some examples for compactifications are presented, especially a type I string model to which a dual model on the base of the heterotic string is known. Then corrections on the gauge coupling constant and on the gauge-kinetic function are discussed. general procedures for their calculation are sketched and applied to some models. The explicitly determinded corrections depend non-holomorphically on the moduli of the compactification manifold. It is explained that this is not in disagreement on the holomorphy of the gauge-kinetic function and how the latter can be extracted from the calculated results. Next D-instantons and their influence on the low-energy action are detailedly analyzed, whereby the zero modes of the instantons and global Abelian symmetries play a central role. A formula for the caclulation of scattering matrix elements in instanton sectors is given. It is to be expected that the considered instantons contribute to the superpotential of the low-energy action. However from the formula it becomes not immediately clear, how far this is possible. The mentioned formula seems to lead to expressions, which are in disagreement to the holomorphy of the superpotential. It is shown that non-holomorphic terms partly simplify, partly are so composed that the result is in accordance with the holomorphy of the superpotential. The D-instanton calculus is then used in order to derive the ADS superpotential, which is known from field theory. That this is possible is to be considered as successful test of the instanton calculus. D-instanton corrections to the gauge-kinetic functions are considered. S duality between the type I and the heterotic string is used in order to determine how the structure of the zero modes of the relevant instantons looks

  4. New two-dimensional effective actions for non-singular black holes

    CERN Document Server

    Kunstatter, Gabor; Taves, Tim

    2015-01-01

    We construct a two-dimensional action that is an extension of spherically symmetric Einstein-Lanczos-Lovelock gravity. The action contains arbitrary functions of the areal radius and the norm squared of its gradient, but the field equations are second order and obey a generalized Birkhoff's theorem. Since the field equations are derived from an action invariant under coordinate transformations preserving spherical symmetry, the diffeomorphism algebra closes. In complete analogy with spherically symmetric Einstein-Lanczos-Lovelock gravity, the Hamiltonian constraint can be written in terms of a generalized Misner-Sharp mass function that determines the form of the vacuum solution. The arbitrary functions in the action allow for vacuum solutions that describe a larger class of interesting non-singular black-hole spacetimes than previously available. These theories can therefore be used to study the dynamics of non-singular black-hole formation and evaporation, thereby shedding light on alternative resolutions o...

  5. Preevaluation of the effectiveness of geothermodynamic action on the oil reserviors of western Siberia

    Energy Technology Data Exchange (ETDEWEB)

    Dyadkon, Yu.D.; Boguslavskii, E.I.; Malofeev, G.V.; Teslyuk, E.V.; Vashurkin, A.T.; Weinblatt, A.B.

    1980-01-01

    A preevaluation for the increase in crude yield and the economic efficiency of goethermodynamic action has been identified as a result of analyzing the hot flooding conditions of oil reserviors in western Siberian fields using petrogeothermal resources.

  6. Reading between the Lines of Online Course Evaluations: Identifiable Actions That Improve Student Perceptions of Teaching Effectiveness and Course Value

    Science.gov (United States)

    Jones, Stephanie J.

    2012-01-01

    Students continue to demand and enroll in online courses, but are not always satisfied with their experiences. The purpose of this study was to determine if students' responses to evaluations for online courses could be used to identify faculty actions that could lead to improved evaluation scores in teaching effectiveness and overall course…

  7. Escalation of Commitment to an Ineffective Course of Action: The Effect of Feedback Having Negative Implications for Self-Identity.

    Science.gov (United States)

    Brockner, Joel; And Others

    1986-01-01

    Examines entrapment, the process by which organizational decision makers escalate commitment to an ineffective course of action to justify allocation of previous resources. Two laboratory experiments exploring individuals' perceptions of entrapment and its effect on their self identity are described. Also discusses practical theoretical…

  8. Maggot therapy´s modes of action : effect of maggot secretions on microbiological, haematological and immunological processes

    NARCIS (Netherlands)

    Plas, Maartje Jeriena Adriana van der

    2009-01-01

    The work described in this thesis focussed on the modes of action of maggot therapy in chronic wounds, especially related to the inflammatory phase of wound healing. For this purpose, the effect of maggot excretions and/or secretions on microbiological, haematological and immunological processes was

  9. Full mass range analysis of the QED effective action for an O(2)xO(3) symmetric field

    CERN Document Server

    Ahmadiniaz, Naser; Raya, Alfredo; Schubert, Christian

    2013-01-01

    An interesting class of background field configurations in quantum electrodynamics (QED) are the O(2)xO(3) symmetric fields, originally introduced by S.L. Adler in 1972. Those backgrounds have some instanton-like properties and yield a one-loop effective action that is highly nontrivial, but amenable to numerical calculation. Here, we use the recently developed "partial-wave-cutoff method" for a full mass range numerical analysis of the effective action for the "standard" O(2)xO(3) symmetric field, modified by a radial suppression factor. At large mass, we are able to match the asymptotics of the physically renormalized effective action against the leading two mass levels of the inverse mass expansion. For small masses, with a suitable choice of the renormalization scheme we obtain stable numerical results even in the massless limit. We analyze the N - point functions in this background and show that, even in the absence of the radial suppression factor, the two-point contribution to the effective action is t...

  10. Parent Drug Education: A Participatory Action Research Study into Effective Communication about Drugs between Parents and Unrelated Young People

    Science.gov (United States)

    Mallick, Jane

    2007-01-01

    Parent drug education is considered a key aspect of drug prevention. Effective communication acts as protective factor for drug misuse in young people. This study is a Participatory Action Research study of "Drugsbridge", a drug education programme that has an emphasis on facilitating intergenerational communication about drugs between parents and…

  11. Effective action approach to higher-order relativistic tidal interactions in binary systems and their effective one body description

    CERN Document Server

    Bini, Donato; Faye, Guillaume

    2012-01-01

    The gravitational-wave signal from inspiralling neutron-star--neutron-star (or black-hole--neutron-star) binaries will be influenced by tidal coupling in the system. An important science goal in the gravitational-wave detection of these systems is to obtain information about the equation of state of neutron star matter via the measurement of the tidal polarizability parameters of neutron stars. To extract this piece of information will require to have accurate analytical descriptions of both the motion and the radiation of tidally interacting binaries. We improve the analytical description of the late inspiral dynamics by computing the next-to-next-to-leading order relativistic correction to the tidal interaction energy. Our calculation is based on an effective-action approach to tidal interactions, and on its transcription within the effective-one-body formalism. We find that second-order relativistic effects (quadratic in the relativistic gravitational potential $u=G(m_1 +m_2)/(c^2 r)$) significantly increa...

  12. The Paris Declaration on Aid Effectiveness and the Accra Agenda for Action

    OpenAIRE

    OECD Development Co-operation Directorate, DCD-DAC

    2008-01-01

    The Paris Declaration, endorsed on 2 March 2005, is an international agreement to which over one hundred Ministers, Heads of Agencies and other Senior Officials adhered and committed their countries and organisations to continue to increase efforts in harmonisation, alignment and managing aid for results with a set of monitorable actions and indicators. The Accra Agenda for Action (AAA) was drawn up in 2008 and builds on the commitments agreed in the Paris Declaration.

  13. Effect of metal complexation to anti-inflammatory over the action against oxidative and free radicals: ketoprofen action; Efeito da complexacao de metais aos antiinflamatorios na acao contra agentes oxidativos e radicais livres: acao do cetoprofeno

    Energy Technology Data Exchange (ETDEWEB)

    Manente, Francine Alessandra; Mello, Lucas Rosolen de Almeida; Vellosa, Jose Carlos Rebuglio [UEPG, Universidade Estadual de Ponta Grossa, Departamento de Analises Clinicas eToxicologicas, Ponta Grossa, PR (Brazil); Khalil, Omar Arafat Kdudsi [IFG, Instituto Federal de Goias, Campus de Formosa, Formosa - GO (Brazil); Carvalho, Claudio Teodoro de [UFGD, Universidade Federal da Grande Dourados, Faculdade de Ciencias Exatas e Tecnologias, Dourados-MS (Brazil); Bannach, Gilbert [UNESP, Universidade Estadual Paulista Julio de Mesquita Filho, Faculdade de Ciencias de Bauru, Bauru, SP (Brazil)

    2011-07-01

    Free radicals are highly reactive species generated in living organisms for the purpose of protection. However, in some circumstances, they are responsible for the occurrence or aggravation of tissue damage. Many anti-inflammatory drugs have a direct effect on free radicals and not radical reactive species, which contributes to its actions against inflammation. Ketoprofen is a nonsteroidal anti-inflammatory agent that generates free radicals by photo irradiation and has an important hemolytic effect with that. The complexation of metals to different drugs has been used as a strategy to improve the pharmacological action of different molecules and reduce their side effects. This paper presents the results of ketoprofen and their metallic complexes action on erythrocytes and free radicals. It was observed that the cerium enhances the scavenger properties of ketoprofen on free radicals, while copper enhances its action over non-radical oxidants. Copper also reduced the hemolytic effect presented by ketoprofen meanwhile its cerium derivative maintained it. (author)

  14. Time for actions in lucid dreams: Effects of task modality, length, and complexity

    Directory of Open Access Journals (Sweden)

    Daniel eErlacher

    2014-01-01

    Full Text Available The relationship between time in dreams and real time has intrigued scientists for centuries. The question if actions in dreams take the same time as in wakefulness can be tested by using lucid dreams where the dreamer is able to mark time intervals with prearranged eye movements that can be objectively identified in EOG recordings. Previous research showed an equivalence of time for counting in lucid dreams and in wakefulness (Erlacher & Schredl, 2004; LaBerge, 1985, but Erlacher and Schredl (2004 found that performing squats required about 40 % more time in lucid dreams than in the waking state. To find out if the task modality, the task length, or the task complexity results in prolonged times in lucid dreams, an experiment with three different conditions was conducted.In the first condition, five proficient lucid dreamers spent one to three non-consecutive nights in the sleep laboratory. Participants counted to 10, 20 and 30 in wakefulness and in their lucid dreams. Lucidity and task intervals were time stamped with left-right-left-right eye movements. The same procedure was used for the second condition where eight lucid dreamers had to walk 10, 20 or 30 steps. In the third condition, eight lucid dreamers performed a gymnastics routine, which in the waking state lasted the same time as walking 10 steps.Again, we found that performing a motor task in a lucid dream requires more time than in wakefulness. Longer durations in the dream state were present for all three tasks, but significant differences were found only for the tasks with motor activity (walking and gymnastics. However, no difference was found for relative times (no disproportional time effects and a more complex motor task did not result in more prolonged times. Longer durations in lucid dreams might be related to the lack of muscular feedback or slower neural processing during REM sleep. Future studies should explore factors that might be associated with prolonged durations.

  15. Time for actions in lucid dreams: effects of task modality, length, and complexity.

    Science.gov (United States)

    Erlacher, Daniel; Schädlich, Melanie; Stumbrys, Tadas; Schredl, Michael

    2013-01-01

    The relationship between time in dreams and real time has intrigued scientists for centuries. The question if actions in dreams take the same time as in wakefulness can be tested by using lucid dreams where the dreamer is able to mark time intervals with prearranged eye movements that can be objectively identified in EOG recordings. Previous research showed an equivalence of time for counting in lucid dreams and in wakefulness (LaBerge, 1985; Erlacher and Schredl, 2004), but Erlacher and Schredl (2004) found that performing squats required about 40% more time in lucid dreams than in the waking state. To find out if the task modality, the task length, or the task complexity results in prolonged times in lucid dreams, an experiment with three different conditions was conducted. In the first condition, five proficient lucid dreamers spent one to three non-consecutive nights in the sleep laboratory. Participants counted to 10, 20, and 30 in wakefulness and in their lucid dreams. Lucidity and task intervals were time stamped with left-right-left-right eye movements. The same procedure was used for the second condition where eight lucid dreamers had to walk 10, 20, or 30 steps. In the third condition, eight lucid dreamers performed a gymnastics routine, which in the waking state lasted the same time as walking 10 steps. Again, we found that performing a motor task in a lucid dream requires more time than in wakefulness. Longer durations in the dream state were present for all three tasks, but significant differences were found only for the tasks with motor activity (walking and gymnastics). However, no difference was found for relative times (no disproportional time effects) and a more complex motor task did not result in more prolonged times. Longer durations in lucid dreams might be related to the lack of muscular feedback or slower neural processing during REM sleep. Future studies should explore factors that might be associated with prolonged durations.

  16. Effect of knockout of α2δ-1 on action potentials in mouse sensory neurons.

    Science.gov (United States)

    Margas, Wojciech; Ferron, Laurent; Nieto-Rostro, Manuela; Schwartz, Arnold; Dolphin, Annette C

    2016-08-01

    Gene deletion of the voltage-gated calcium channel auxiliary subunit α2δ-1 has been shown previously to have a cardiovascular phenotype, and a reduction in mechano- and cold sensitivity, coupled with delayed development of neuropathic allodynia. We have also previously shown that dorsal root ganglion (DRG) neuron calcium channel currents were significantly reduced in α2δ-1 knockout mice. To extend our findings in these sensory neurons, we have examined here the properties of action potentials (APs) in DRG neurons from α2δ-1 knockout mice in comparison to their wild-type (WT) littermates, in order to dissect how the calcium channels that are affected by α2δ-1 knockout are involved in setting the duration of individual APs and their firing frequency. Our main findings are that there is reduced Ca(2+) entry on single AP stimulation, particularly in the axon proximal segment, reduced AP duration and reduced firing frequency to a 400 ms stimulation in α2δ-1 knockout neurons, consistent with the expected role of voltage-gated calcium channels in these events. Furthermore, lower intracellular Ca(2+) buffering also resulted in reduced AP duration, and a lower frequency of AP firing in WT neurons, mimicking the effect of α2δ-1 knockout. By contrast, we did not obtain any consistent evidence for the involvement of Ca(2+)-activation of large conductance calcium-activated potassium (BK) and small conductance calcium-activated potassium (SK) channels in these events. In conclusion, the reduced Ca(2+) elevation as a result of single AP stimulation is likely to result from the reduced duration of the AP in α2δ-1 knockout sensory neurons.This article is part of the themed issue 'Evolution brings Ca(2+) and ATP together to control life and death'. PMID:27377724

  17. Time for actions in lucid dreams: effects of task modality, length, and complexity.

    Science.gov (United States)

    Erlacher, Daniel; Schädlich, Melanie; Stumbrys, Tadas; Schredl, Michael

    2013-01-01

    The relationship between time in dreams and real time has intrigued scientists for centuries. The question if actions in dreams take the same time as in wakefulness can be tested by using lucid dreams where the dreamer is able to mark time intervals with prearranged eye movements that can be objectively identified in EOG recordings. Previous research showed an equivalence of time for counting in lucid dreams and in wakefulness (LaBerge, 1985; Erlacher and Schredl, 2004), but Erlacher and Schredl (2004) found that performing squats required about 40% more time in lucid dreams than in the waking state. To find out if the task modality, the task length, or the task complexity results in prolonged times in lucid dreams, an experiment with three different conditions was conducted. In the first condition, five proficient lucid dreamers spent one to three non-consecutive nights in the sleep laboratory. Participants counted to 10, 20, and 30 in wakefulness and in their lucid dreams. Lucidity and task intervals were time stamped with left-right-left-right eye movements. The same procedure was used for the second condition where eight lucid dreamers had to walk 10, 20, or 30 steps. In the third condition, eight lucid dreamers performed a gymnastics routine, which in the waking state lasted the same time as walking 10 steps. Again, we found that performing a motor task in a lucid dream requires more time than in wakefulness. Longer durations in the dream state were present for all three tasks, but significant differences were found only for the tasks with motor activity (walking and gymnastics). However, no difference was found for relative times (no disproportional time effects) and a more complex motor task did not result in more prolonged times. Longer durations in lucid dreams might be related to the lack of muscular feedback or slower neural processing during REM sleep. Future studies should explore factors that might be associated with prolonged durations. PMID:24474942

  18. Different mechanisms for role relations versus verb-action congruence effects: evidence from ERPs in picture-sentence verification.

    Science.gov (United States)

    Knoeferle, Pia; Urbach, Thomas P; Kutas, Marta

    2014-10-01

    Extant accounts of visually situated language processing do make general predictions about visual context effects on incremental sentence comprehension; these, however, are not sufficiently detailed to accommodate potentially different visual context effects (such as a scene-sentence mismatch based on actions versus thematic role relations, e.g., (Altmann & Kamide, 2007; Knoeferle & Crocker, 2007; Taylor & Zwaan, 2008; Zwaan & Radvansky, 1998)). To provide additional data for theory testing and development, we collected event-related brain potentials (ERPs) as participants read a subject-verb-object sentence (500 ms SOA in Experiment 1 and 300 ms SOA in Experiment 2), and post-sentence verification times indicating whether or not the verb and/or the thematic role relations matched a preceding picture (depicting two participants engaged in an action). Though incrementally processed, these two types of mismatch yielded different ERP effects. Role-relation mismatch effects emerged at the subject noun as anterior negativities to the mismatching noun, preceding action mismatch effects manifest as centro-parietal N400s greater to the mismatching verb, regardless of SOAs. These two types of mismatch manipulations also yielded different effects post-verbally, correlated differently with a participant's mean accuracy, verbal working memory and visual-spatial scores, and differed in their interactions with SOA. Taken together these results clearly implicate more than a single mismatch mechanism for extant accounts of picture-sentence processing to accommodate. PMID:25216075

  19. Defining soldier equipment trade space: load effects on combat marksmanship and perception-action coupling.

    Science.gov (United States)

    Palmer, Christopher J; Bigelow, Carol; Van Emmerik, Richard E A

    2013-01-01

    Soldier equipment compromises task performance as temporal constraints during critical situations and load increase inertial and interactive forces during movement. Methods are necessary to optimise equipment that relate task performance to underlying coordination and perception-action coupling. Employing ecological task analysis and methods from dynamical systems theory, equipment load and coordination was examined during two sub-tasks embedded in combat performance, threat discrimination and dynamic marksmanship. Perception-action coupling was degraded with load during threat discrimination, leading to delays in functional reaction time. Reduced speed and accuracy during dynamic marksmanship under load was related to disrupted segmental coordination and adaptability during postural transitions between targets. These results show how reduced performance under load relates to coordination changes and perception-action coupling. These changes in functional capability are directly related to soldier survivability in combat. The methods employed may aid equipment design towards more optimised performance by modifying equipment or its distribution on humans. PMID:24028557

  20. Combined effects of estrogenic chemicals with the same mode of action using an estrogen receptor binding bioassay.

    Science.gov (United States)

    Yang, Rong; Li, Na; Ma, Mei; Wang, Zijian

    2014-11-01

    The increasing amounts of various estrogenic chemicals coexisting in the aquatic environment may pose environmental risks. While the concept of estradiol equivalent (EEQ) has been frequently applied in studying estrogenic mixtures, few experiments have been done to prove its reliability. In this study, the reliability of EEQ and the related model concentration addition (CA) was verified based on the two-hybrid recombinant yeast bioassay when all mixture components had the same mode of action and target of action. Our results showed that the measured estrogenic effects could be well predicted by CA and EEQ for all laboratory-made mixtures using two designs, despite the varying estrogenic activity, concentration levels and ratios of the test chemicals. This suggests that when an appropriate endpoint and its relevant bioassay are chosen, CA should be valid and the application of EEQ in predicting the effect of non-equi-effect mixtures is feasible. PMID:25461542

  1. Reinvigorating International Climate Policy: A Comprehensive Framework for Effective Nonstate Action

    NARCIS (Netherlands)

    Chan, Sander; Asselt, van Harro; Hale, Thomas; Hoehne, N.E.

    2015-01-01

    As countries negotiate a new climate agreement for the United Nations climate conference in December 2015, a groundswell of climate actions is emerging as cities, regions, businesses and civil society groups act on mitigation and adaptation, independently, with each other and with national governmen

  2. Striving for the moral self : The effects of recalling past moral actions on future moral behavior

    NARCIS (Netherlands)

    Jordan, J.; Mullen, E.; Murnighan, J.K.

    2011-01-01

    People's desires to see themselves as moral actors can contribute to their striving for and achievement of a sense of self-completeness. The authors use self-completion theory to predict (and show) that recalling one's own (im)moral behavior leads to compensatory rather than consistent moral action

  3. An integrated approach for prospectively investigating a mode-of-action for rodent liver effects

    International Nuclear Information System (INIS)

    Registration of new plant protection products (e.g., herbicide, insecticide, or fungicide) requires comprehensive mammalian toxicity evaluation including carcinogenicity studies in two species. The outcome of the carcinogenicity testing has a significant bearing on the overall human health risk assessment of the substance and, consequently, approved uses for different crops across geographies. In order to understand the relevance of a specific tumor finding to human health, a systematic, transparent, and hypothesis-driven mode of action (MoA) investigation is, appropriately, an expectation by the regulatory agencies. Here, we describe a novel approach of prospectively generating the MoA data by implementing additional end points to the standard guideline toxicity studies with sulfoxaflor, a molecule in development. This proactive MoA approach results in a more robust integration of molecular with apical end points while minimizing animal use. Sulfoxaflor, a molecule targeting sap-feeding insects, induced liver effects (increased liver weight due to hepatocellular hypertrophy) in an initial palatability probe study for selecting doses for subsequent repeat-dose dietary studies. This finding triggered the inclusion of dose-response investigations of the potential key events for rodent liver carcinogenesis, concurrent with the hazard assessment studies. As predicted, sulfoxaflor induced liver tumors in rats and mice in the bioassays. The MoA data available by the time of the carcinogenicity finding supported the conclusion that the carcinogenic potential of sulfoxaflor was due to CAR/PXR nuclear receptor activation with subsequent hepatocellular proliferation. This MoA was not considered to be relevant to humans as sulfoxaflor is unlikely to induce hepatocellular proliferation in humans and therefore would not be a human liver carcinogen. - Highlights: • We prospectively generated MoA data into standard guideline toxicity studies. • A proactive MoA approach

  4. An integrated approach for prospectively investigating a mode-of-action for rodent liver effects

    Energy Technology Data Exchange (ETDEWEB)

    LeBaron, Matthew J., E-mail: MJLeBaron@dow.com [Toxicology and Environmental Research and Consulting, The Dow Chemical Company, Midland, MI, 48674 (United States); Geter, David R., E-mail: dave.geter@gmail.com [Toxicology and Environmental Research and Consulting, The Dow Chemical Company, Midland, MI, 48674 (United States); Rasoulpour, Reza J. [Toxicology and Environmental Research and Consulting, The Dow Chemical Company, Midland, MI, 48674 (United States); Gollapudi, B. Bhaskar, E-mail: BBGollapudi@dow.com [Toxicology and Environmental Research and Consulting, The Dow Chemical Company, Midland, MI, 48674 (United States); Thomas, Johnson, E-mail: JThomas4@dow.com [Toxicology and Environmental Research and Consulting, The Dow Chemical Company, Midland, MI, 48674 (United States); Murray, Jennifer, E-mail: AMurray@dow.com [Toxicology and Environmental Research and Consulting, The Dow Chemical Company, Midland, MI, 48674 (United States); Kan, H. Lynn, E-mail: HLKan@dow.com [Toxicology and Environmental Research and Consulting, The Dow Chemical Company, Midland, MI, 48674 (United States); Wood, Amanda J., E-mail: AJWood@dow.com [Toxicology and Environmental Research and Consulting, The Dow Chemical Company, Midland, MI, 48674 (United States); Elcombe, Cliff, E-mail: CliffElcombe@cxrbiosciences.com [CXR Biosciences, 2 James Lindsay Place, Dundee Technopole, Dundee, DD1 5JJ, Scotland (United Kingdom); Vardy, Audrey, E-mail: audrey_vardy@europe.bd.com [CXR Biosciences, 2 James Lindsay Place, Dundee Technopole, Dundee, DD1 5JJ, Scotland (United Kingdom); McEwan, Jillian, E-mail: jillian.mcewan@rtmcewan.co.uk [CXR Biosciences, 2 James Lindsay Place, Dundee Technopole, Dundee, DD1 5JJ, Scotland (United Kingdom); Terry, Claire, E-mail: CTerry@dow.com [Dow AgroSciences, Abingdon, Oxfordshire (United Kingdom); Billington, Richard, E-mail: RBillington@dow.com [Dow AgroSciences, Abingdon, Oxfordshire (United Kingdom)

    2013-07-15

    Registration of new plant protection products (e.g., herbicide, insecticide, or fungicide) requires comprehensive mammalian toxicity evaluation including carcinogenicity studies in two species. The outcome of the carcinogenicity testing has a significant bearing on the overall human health risk assessment of the substance and, consequently, approved uses for different crops across geographies. In order to understand the relevance of a specific tumor finding to human health, a systematic, transparent, and hypothesis-driven mode of action (MoA) investigation is, appropriately, an expectation by the regulatory agencies. Here, we describe a novel approach of prospectively generating the MoA data by implementing additional end points to the standard guideline toxicity studies with sulfoxaflor, a molecule in development. This proactive MoA approach results in a more robust integration of molecular with apical end points while minimizing animal use. Sulfoxaflor, a molecule targeting sap-feeding insects, induced liver effects (increased liver weight due to hepatocellular hypertrophy) in an initial palatability probe study for selecting doses for subsequent repeat-dose dietary studies. This finding triggered the inclusion of dose-response investigations of the potential key events for rodent liver carcinogenesis, concurrent with the hazard assessment studies. As predicted, sulfoxaflor induced liver tumors in rats and mice in the bioassays. The MoA data available by the time of the carcinogenicity finding supported the conclusion that the carcinogenic potential of sulfoxaflor was due to CAR/PXR nuclear receptor activation with subsequent hepatocellular proliferation. This MoA was not considered to be relevant to humans as sulfoxaflor is unlikely to induce hepatocellular proliferation in humans and therefore would not be a human liver carcinogen. - Highlights: • We prospectively generated MoA data into standard guideline toxicity studies. • A proactive MoA approach

  5. From primed concepts to action: A meta-analysis of the behavioral effects of incidentally presented words.

    Science.gov (United States)

    Weingarten, Evan; Chen, Qijia; McAdams, Maxwell; Yi, Jessica; Hepler, Justin; Albarracín, Dolores

    2016-05-01

    A meta-analysis assessed the behavioral impact of and psychological processes associated with presenting words connected to an action or a goal representation. The average and distribution of 352 effect sizes (analyzed using fixed-effects and random-effects models) was obtained from 133 studies (84 reports) in which word primes were incidentally presented to participants, with a nonopposite control group, before measuring a behavioral dependent variable. Findings revealed a small behavioral priming effect (dFE = 0.332, dRE = 0.352), which was robust across methodological procedures and only minimally biased by the publication of positive (vs. negative) results. Theory testing analyses indicated that more valued behavior or goal concepts (e.g., associated with important outcomes or values) were associated with stronger priming effects than were less valued behaviors. Furthermore, there was some evidence of persistence of goal effects over time. These results support the notion that goal activation contributes over and above perception-behavior in explaining priming effects. In summary, theorizing about the role of value and satisfaction in goal activation pointed to stronger effects of a behavior or goal concept on overt action. There was no evidence that expectancy (ease of achieving the goal) moderated priming effects. (PsycINFO Database Record PMID:26689090

  6. Intentional Action and Action Slips.

    Science.gov (United States)

    Heckhausen, Heinz; Beckmann, Jurgen

    1990-01-01

    An explanation of action slips is offered that examines controlled actions in the context of an intentional behavior theory. Actions are considered guided by mentally represented intentions, subdivided into goal intentions and contingent instrumental intentions. Action slips are categorized according to problem areas in the enactment of goal…

  7. Effects of nerve growth factor on the action potential duration and repolarizing currents in a rabbit model of myocardial infarction

    Institute of Scientific and Technical Information of China (English)

    Yun-Feng Lan; Yang Li; Jian-Cheng Zhang; Jin-Lao Gao; Xue-Ping Wang; Zhou Fang; Yi-Cheng Fu; Mei-Yan Chen; Min Lin; Qiao Xue

    2013-01-01

    Objectives To investigate the effect of nerve growth factor (NGF) on the action potential and potassium currents of non-infarcted myocardium in the myocardial infarcted rabbit model. Methods Rabbits with occlusion of the left anterior descending coronary artery were prepared and allowed to recover for eight weeks (healed myocardial infarction, HMI). During ligation surgery of the left coronary artery, a polyethylene tube was placed near the left stellate ganglion in the subcutis of the neck for the purpose of administering NGF 400 U/d for eight weeks (HMI + NGF group). Cardiomyocytes were isolated from regions of the non-infarcted left ventricular wall and the action potentials and ion currents in these cells were recorded using whole-cell patch clamps. Results Compared with HMI and control cardiomyocytes, significant prolongation of APD50 or APD90 (Action potential duration (APD) measured at 50% and 90% of repolarization) in HMI + NGF cardiomyocytes was found. The results showed that the 4-aminopyridine sensitive transient outward potassium current (Ito), the rapidly activated omponent of delayed rectifier potassium current (IKr), the slowly activated component of delayed rectifier potassium current (IKs), and the L-type calcium current (ICaL) were significantly altered in NGF + HMI cardiomyocytes compared with HMI and control cells. Conclusions Our results suggest that NGF treatment significantly prolongs APD in HMI cardiomyocytes and that a decrease in outward potassium currents and an increase of inward Ca2+ current are likely the underlying mechanism of action.

  8. Key Issues in the Modes of Action and Effects of Trichloroethylene Metabolites for Liver and Kidney Tumorigenesis

    OpenAIRE

    Caldwell, Jane C.; Keshava, Nagalakshmi

    2006-01-01

    Trichloroethylene (TCE) exposure has been associated with increased risk of liver and kidney cancer in both laboratory animal and epidemiologic studies. The U.S. Environmental Protection Agency 2001 draft TCE risk assessment concluded that it is difficult to determine which TCE metabolites may be responsible for these effects, the key events involved in their modes of action (MOAs), and the relevance of these MOAs to humans. In this article, which is part of a mini-monograph on key issues in ...

  9. Computational modeling of voltage-gated Ca channels inhibition: identification of different effects on uterine and cardiac action potentials

    Directory of Open Access Journals (Sweden)

    Wing Chiu eTong

    2014-10-01

    Full Text Available The uterus and heart share the important physiological feature whereby contractile activation of the muscle tissue is regulated by the generation of periodic, spontaneous electrical action potentials (APs. Preterm birth arising from premature uterine contractions is a major complication of pregnancy and there remains a need to pursue avenues of research that facilitate the use of drugs, tocolytics, to limit these inappropriate contractions without deleterious actions on cardiac electrical excitation. A novel approach is to make use of mathematical models of uterine and cardiac APs, which incorporate many ionic currents contributing to the AP forms, and test the cell-specific responses to interventions. We have used three such models – of uterine smooth muscle cells (USMC, cardiac sinoatrial node cells (SAN and ventricular cells – to investigate the relative effects of reducing two important voltage-gated Ca currents – the L-type (ICaL and T-type (ICaT Ca currents. Reduction of ICaL (10% alone, or ICaT (40% alone, blunted USMC APs with little effect on ventricular APs and only mild effects on SAN activity. Larger reductions in either current further attenuated the USMC APs but with also greater effects on SAN APs. Encouragingly, a combination of ICaL and ICaT reduction did blunt USMC APs as intended with little detriment to APs of either cardiac cell type. Subsequent overlapping maps of ICaL and ICaT inhibition profiles from each model revealed a range of combined reductions of ICaL and ICaT over which an appreciable diminution of USMC APs could be achieved with no deleterious action on cardiac SAN or ventricular APs. This novel approach illustrates the potential for computational biology to inform us of possible uterine and cardiac cell-specific mechanisms. Incorporating such computational approaches in future studies directed at designing new, or repurposing existing, tocolytics will be beneficial for establishing a desired uterine

  10. A frame-dependent gravitational effective action mimics a cosmological constant, but modifies the black hole horizon

    CERN Document Server

    Adler, Stephen L

    2016-01-01

    A frame dependent effective action motivated by the postulates of three-space general coordinate invariance and Weyl scaling invariance exactly mimics a cosmological constant in Robertson-Walker spacetimes. However, in a static spherically symmetric Schwarzschild-like geometry it modifies the black hole horizon structure within microscopic distances of the nominal horizon, in such a way that $g_{00}$ never vanishes. This could have important implications for the black hole "information paradox".

  11. A survey of the effective factors in students' adherence to university dress code policy, using the theory of reasoned action

    OpenAIRE

    MOHAMMAD HOSSEIN KAVEH; LEILA MORADI; MARYAM HESAMPOUR; JAFAR HASAN ZADEH

    2015-01-01

    Introduction: Recognizing the determinants of behavior plays a major role in identification and application of effective strategies for encouraging individuals to follow the intended pattern of behavior. The present study aimed to analyze the university students’ behaviors regarding the amenability to dress code, using the theory of reasoned action (TRA). Methods: In this cross sectional study, 472 students were selected through multi-stage random sampling. The data were ...

  12. Maggot therapy´s modes of action: effect of maggot secretions on microbiological, haematological and immunological processes

    OpenAIRE

    Plas, Maartje Jeriena Adriana van der

    2009-01-01

    The work described in this thesis focussed on the modes of action of maggot therapy in chronic wounds, especially related to the inflammatory phase of wound healing. For this purpose, the effect of maggot excretions and/or secretions on microbiological, haematological and immunological processes was investigated. The results showed that maggot excretions/secretions breakdown biofilms of both Gram-positive and Gram-negative bacteria, exposing them to the immune system, antibiotics, and ingesti...

  13. Pretest and posttest calculations of Semiscale Test S-07-10D with the TRAC computer program

    International Nuclear Information System (INIS)

    The Transient Reactor Analysis Code (TRAC) developed at the Los Alamos National Laboratory was used to predict the behavior of the small-break experiment designated Semiscale S-07-10D. This test simulates a 10 per cent communicative cold-leg break with delayed Emergency Core Coolant injection and blowdown of the broken-loop steam generator secondary. Both pretest calculations that incorporated measured initial conditions and posttest calculations that incorporated measured initial conditions and measured transient boundary conditions were completed. The posttest calculated parameters were generally between those obtained from pretest calculations and those from the test data. The results are strongly dependent on depressurization rate and, hence, on break flow

  14. Time for actions in lucid dreams: effects of task modality, length, and complexity

    OpenAIRE

    Erlacher, Daniel; Schädlich, Melanie; Stumbrys, Tadas; Schredl, Michael

    2014-01-01

    The relationship between time in dreams and real time has intrigued scientists for centuries. The question if actions in dreams take the same time as in wakefulness can be tested by using lucid dreams where the dreamer is able to mark time intervals with prearranged eye movements that can be objectively identified in EOG recordings. Previous research showed an equivalence of time for counting in lucid dreams and in wakefulness (LaBerge, 1985; Erlacher and Schredl, 2004), but Erlacher and Schr...

  15. Time for actions in lucid dreams: Effects of task modality, length, and complexity

    OpenAIRE

    Daniel eErlacher; Melanie eSchädlich; Tadas eStumbrys; Michael eSchredl

    2014-01-01

    The relationship between time in dreams and real time has intrigued scientists for centuries. The question if actions in dreams take the same time as in wakefulness can be tested by using lucid dreams where the dreamer is able to mark time intervals with prearranged eye movements that can be objectively identified in EOG recordings. Previous research showed an equivalence of time for counting in lucid dreams and in wakefulness (Erlacher & Schredl, 2004; LaBerge, 1985), but Erlacher and Schred...

  16. Motivating Exercise: The Interactive Effect of General Action Goals and Past Behavior on Physical Activity

    OpenAIRE

    Hepler, Justin; Wang, Wei; Albarracin, Dolores

    2011-01-01

    Although exercise is recognized as a powerful tool to combat obesity, remarkably few US adults pursue adequate amounts of exercise, with one major impediment being a lack of motivation for active behaviors. Recent empirical work has demonstrated that behavior can be guided by goals to be generally active or inactive. In the present paper, an experiment is presented in which participants played or observed a video game, were primed with action or inaction goals, and practiced a stretching exer...

  17. Multi-Scale Action Effectiveness Research in the Lower Columbia River and Estuary, 2012

    Energy Technology Data Exchange (ETDEWEB)

    Johnson, Gary E.; Sather, Nichole K.; Storch, Adam; Johnson, Jeff; Skalski, J. R.; Teel, D. J.; Brewer, Taylor; Bryson, Amanda J.; Dawley, Earl M.; Kuligowski, D. R.; Whitesel, T.; Mallette, Christine

    2013-11-30

    The study reported herein was conducted for the U.S. Army Corps of Engineers, Portland District (USACE) by researchers at the Pacific Northwest National Laboratory (PNNL), Oregon Department of Fish and Wildlife (ODFW), National Marine Fisheries Service (NMFS), University of Washington (UW), and U.S. Fish and Wildlife Service (USFWS). The goal of the study was to evaluate the ecological benefits of restoration actions for juvenile salmon in the lower Columbia River and estuary (LCRE; rkm 0–234).

  18. Policies, Actions and Effects for China s Forestry Response to Global Climate Change

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    Climate change is a great concern of various countries, the public and science community, and forest plays an important role in mitigating climate change. The paper made a comprehensive analysis regarding the policy selections of China to promote forestry response to the global climate change, and elaborated the concrete actions and achievements in this regard. Policy selections include: 1) Reinforce tree planting and afforestation, increase the forested area and enhance the capacity of carbon sequestration...

  19. Joint Action of a Pair of Rowers in a Race: Shared Experiences of Effectiveness Are Shaped by Interpersonal Mechanical States.

    Science.gov (United States)

    R'Kiouak, Mehdi; Saury, Jacques; Durand, Marc; Bourbousson, Jérôme

    2016-01-01

    The purpose of this study was to understand how a single pair of expert individual rowers experienced their crew functioning in natural conditions when asked to practice a joint movement for the first time. To fulfill this objective, we conducted a field study of interpersonal coordination that combined phenomenological and mechanical data from a coxless pair activity, to analyze the dynamics of the (inter)subjective experience compared with the dynamics of the team coordination. Using an enactivist approach to social couplings, these heterogeneous data were combined to explore the salience (and accuracy) of individuals' shared experiences of their joint action. First, we determined how each rower experienced the continuous crew functioning states (e.g., feelings of the boat's glide). Second, the phenomenological data helped us to build several categories of oar strokes (i.e., cycles), experienced by the rowers as either detrimentally or effectively performed strokes. Third, the mechanical signatures that correlated with each phenomenological category were tracked at various level of organization (i.e., individual-, interpersonal-, and boat-levels). The results indicated that (a) the two rowers did not pay attention to their joint action during most of the cycles, (b) some cycles were simultaneously lived as a salient, meaningful experience of either a detrimental (n = 15 cycles) or an effective (n = 18 cycles) joint action, and (c) the mechanical signatures diverged across the delineated phenomenological categories, suggesting that the way in which the cycles were experienced emerged from the variance in some mechanical parameters (i.e., differences in peak force level and mean force). Notably, the mechanical measures that helped to explain differences within the phenomenological categories were found at the interpersonal level of analysis, thus suggesting an intentional inter-personal mode of regulation of their joint action. This result is further challenged and

  20. The effect of action video game experience on task-switching

    Science.gov (United States)

    Green, C.Shawn; Sugarman, Michael A.; Medford, Katherine; Klobusicky, Elizabeth; Daphne Bavelier

    2012-01-01

    There is now a substantial body of work demonstrating that action video game experience results in enhancements in a wide variety of perceptual skills. More recently, several groups have also demonstrated improvements in abilities that are more cognitive in nature, in particular, the ability to efficiently switch between tasks. In a series of four experiments, we add to this body of work, demonstrating that the action video game player advantage is not exclusively due to an ability to map manual responses onto arbitrary buttons, but rather generalizes to vocal responses, is not restricted to tasks that are perceptual in nature (e.g. respond to a physical dimension of the stimulus such as its color), but generalizes to more cognitive tasks (e.g. is a number odd or even), and is present whether the switch requires a goal-switch or only a motor switch. Finally, a training study establishes that the relationship between the reduction in switch cost and action game playing is causal. PMID:22393270

  1. The Effects of Action and Violence in Television Programs on the Social Behavior and Imaginative Play of Preschool Children.

    Science.gov (United States)

    Huston-Stein, Aletha; And Others

    The independent contributions of action and violence in television programs to children's attention and social behavior were investigated. Pairs of preschool children were assigned to one of four television conditions (1) high action-high violence, (2) high action-low violence, (3) low action-low violence, or (4) no television. Action was defined…

  2. Transforming Conflict into Effective Action: A Case Study on the Effects of Anthropogenic Sound on Marine Mammals

    Science.gov (United States)

    Lewandowski, Jill K.

    Like many wicked environmental problems of our time, marine sound and its potential effects on marine mammals is characterized by high levels of scientific uncertainty, diversified values across many stakeholder groups, political and regulatory complexities, and a continually evolving ecological and social environment. Further, the history of conflict and the relationships between major actors has rooted the issue firmly in identity conflict where prejudices lead to avoidance of working together. What results is continuing controversy, failed management decisions, litigation and an increasing frustration by all parties on why a better solution cannot be found. Ultimately, the intractability of the issue is not about the science, nor will the science ever tame the issue on its own. Rather, the issue is intractable because of the conflict between people about the most appropriate path forward. It is then imperative to understand, address, and transform this conflict in order to move off the decision carousel toward improved conservation outcomes and sustainable decisions for all. This research used an explanatory case study approach to quantitatively and qualitatively investigate the context and reasoning underlying conflict on this issue. Three methods were used in order to triangulate the data, and thus add rigor, including: (1) a document review of 230 publications: (2) exploratory interviews with 10 collaborative action experts and semi-structured interviews with 58 marine mammals and sound stakeholders; and (3) participant review of selected analyses. Data elucidate how different stakeholder groups define the problem and potential solutions, how they see their role and view the role of other stakeholders, specific experiences that increased or decrease conflict, and design preferences for a collaborative effort. These data are combined with conflict transformation principles to provide recommendations for a collaborative, transformative framework designed to

  3. A3 Adenosine Receptor Allosteric Modulator Induces an Anti-Inflammatory Effect: In Vivo Studies and Molecular Mechanism of Action

    Directory of Open Access Journals (Sweden)

    Shira Cohen

    2014-01-01

    Full Text Available The A3 adenosine receptor (A3AR is overexpressed in inflammatory cells and in the peripheral blood mononuclear cells of individuals with inflammatory conditions. Agonists to the A3AR are known to induce specific anti-inflammatory effects upon chronic treatment. LUF6000 is an allosteric compound known to modulate the A3AR and render the endogenous ligand adenosine to bind to the receptor with higher affinity. The advantage of allosteric modulators is their capability to target specifically areas where adenosine levels are increased such as inflammatory and tumor sites, whereas normal body cells and tissues are refractory to the allosteric modulators due to low adenosine levels. LUF6000 administration induced anti-inflammatory effect in 3 experimental animal models of rat adjuvant induced arthritis, monoiodoacetate induced osteoarthritis, and concanavalin A induced liver inflammation in mice. The molecular mechanism of action points to deregulation of signaling proteins including PI3K, IKK, IκB, Jak-2, and STAT-1, resulting in decreased levels of NF-κB, known to mediate inflammatory effects. Moreover, LUF6000 induced a slight stimulatory effect on the number of normal white blood cells and neutrophils. The anti-inflammatory effect of LUF6000, mechanism of action, and the differential effects on inflammatory and normal cells position this allosteric modulator as an attractive and unique drug candidate.

  4. On the Reduction of Vector and Axial-Vector Fields in a Meson Effective Action at O(p4)

    International Nuclear Information System (INIS)

    Starting from an effective NJL-type quark interaction we have derived an effective meson action for the pseudoscalar sector. The vector and axial-vector degrees of freedom have been integrated out, applying the static equations of motion. As the results we have found a (reduced) pseudoscalar meson Lagrangian of the Gasser-Leutwyler type with modified structure coefficients Li. This method has been also used to construct the reduced weak and electromagnetic-weak currents. The application of the reduced Lagrangian and currents has been considered in physical processes. 36 refs., 1 fig., 1 tab

  5. The two-loop effective action and some symmetries of the Riemann tensor and the Kalb-Ramond H field

    CERN Document Server

    Ozkurt, S S

    2003-01-01

    Sometimes ago, it has been proposed in a paper by N.Kaloper and K.A.Meissner (\\PR {\\bf D56} (1997) 7940) that if one makes local redefinitions of fields, it does not change the equations of motion (in the redefined fields); however, this comment has not generally been accepted, namely, the redefined fields satisfy different equations of motion. For this reason, the whole action will be written in terms of the zeroth-order field equations in this paper. In this study, we also observe that N.Kaloper and K.A.Meissner's effective action (\\PR {\\bf D56} (1997) 7940)which has a duality symmetry beyond the first loop, can be written in terms of the zeroth-order field equations if the Riemann tensor and the Kalb-Ramond field have some symmetries. For example, K\\"{a}hler manifolds have these symmetries.

  6. Effects of bacterial action on waste rock producing acid drainage in the Brazilian first uranium mine

    International Nuclear Information System (INIS)

    This work is an evolution of the methodology showed in the paper 'Study of waste of waste rock piles producing acid drainage in the Brazilian first uranium mine', also submitted for INAC2009. Therefore, the present work also related to the determination of chemical species leaching from waste rock pile 4 (WRP4) of the Uranium Mine and Milling Facility located in the Pocos de Caldas Plateau, as well as the generation of acid waters. With the previous experimental setup, it has been observed that not only water and available oxygen are significant to pyrite oxidation reaction, but bacterial activity as well. As a first approach, the present work addresses the same experiment, but now testing without the influence of bacterial action. Therefore, the new methodology and experimental setup is now capable of determining the acidity of water in contact with material from the WRP4 and the concentration of chemical species dissolved as function of time. Such would also show the extent of bacterial action interference on the pyrite oxidation reaction. Results are based on mass balances comparing concentrations of chemical species in the waste rock before the experiment and in the waste rock plus the remaining water after the experiment. In addition, the evolution of the pH and EMF (electromotive force) values along with chemical species quantified through the experiment are presented through graphics. That is followed by discussions on the significance of such results in terms of concentration of the involved chemical species. The present work has also shown the need of improving the injection of air into the system. A more sophisticated experimental setup should be assembled in the near future, which would allow the quantification of differences between experimental tests with and without bacterial action. (author)

  7. Reflecting on mirror mechanisms: motor resonance effects during action observation only present with low-intensity transcranial magnetic stimulation.

    Directory of Open Access Journals (Sweden)

    Michela Loporto

    Full Text Available Transcranial magnetic stimulation (TMS studies indicate that the observation of other people's actions influences the excitability of the observer's motor system. Motor evoked potential (MEP amplitudes typically increase in muscles which would be active during the execution of the observed action. This 'motor resonance' effect is thought to result from activity in mirror neuron regions, which enhance the excitability of the primary motor cortex (M1 via cortico-cortical pathways. The importance of TMS intensity has not yet been recognised in this area of research. Low-intensity TMS predominately activates corticospinal neurons indirectly, whereas high-intensity TMS can directly activate corticospinal axons. This indicates that motor resonance effects should be more prominent when using low-intensity TMS. A related issue is that TMS is typically applied over a single optimal scalp position (OSP to simultaneously elicit MEPs from several muscles. Whether this confounds results, due to differences in the manner that TMS activates spatially separate cortical representations, has not yet been explored. In the current study, MEP amplitudes, resulting from single-pulse TMS applied over M1, were recorded from the first dorsal interosseous (FDI and abductor digiti minimi (ADM muscles during the observation of simple finger abductions. We tested if the TMS intensity (110% vs. 130% resting motor threshold or stimulating position (FDI-OSP vs. ADM-OSP influenced the magnitude of the motor resonance effects. Results showed that the MEP facilitation recorded in the FDI muscle during the observation of index-finger abductions was only detected using low-intensity TMS. In contrast, changes in the OSP had a negligible effect on the presence of motor resonance effects in either the FDI or ADM muscles. These findings support the hypothesis that MN activity enhances M1 excitability via cortico-cortical pathways and highlight a methodological framework by which the

  8. Reflecting on mirror mechanisms: motor resonance effects during action observation only present with low-intensity transcranial magnetic stimulation.

    Science.gov (United States)

    Loporto, Michela; Holmes, Paul S; Wright, David J; McAllister, Craig J

    2013-01-01

    Transcranial magnetic stimulation (TMS) studies indicate that the observation of other people's actions influences the excitability of the observer's motor system. Motor evoked potential (MEP) amplitudes typically increase in muscles which would be active during the execution of the observed action. This 'motor resonance' effect is thought to result from activity in mirror neuron regions, which enhance the excitability of the primary motor cortex (M1) via cortico-cortical pathways. The importance of TMS intensity has not yet been recognised in this area of research. Low-intensity TMS predominately activates corticospinal neurons indirectly, whereas high-intensity TMS can directly activate corticospinal axons. This indicates that motor resonance effects should be more prominent when using low-intensity TMS. A related issue is that TMS is typically applied over a single optimal scalp position (OSP) to simultaneously elicit MEPs from several muscles. Whether this confounds results, due to differences in the manner that TMS activates spatially separate cortical representations, has not yet been explored. In the current study, MEP amplitudes, resulting from single-pulse TMS applied over M1, were recorded from the first dorsal interosseous (FDI) and abductor digiti minimi (ADM) muscles during the observation of simple finger abductions. We tested if the TMS intensity (110% vs. 130% resting motor threshold) or stimulating position (FDI-OSP vs. ADM-OSP) influenced the magnitude of the motor resonance effects. Results showed that the MEP facilitation recorded in the FDI muscle during the observation of index-finger abductions was only detected using low-intensity TMS. In contrast, changes in the OSP had a negligible effect on the presence of motor resonance effects in either the FDI or ADM muscles. These findings support the hypothesis that MN activity enhances M1 excitability via cortico-cortical pathways and highlight a methodological framework by which the neural

  9. Over 10 dB Net Coding Gain Based on 20% Overhead Hard Decision Forward Error Correction in 100G Optical Communication Systems

    DEFF Research Database (Denmark)

    Li, Bomin; Larsen, Knud J.; Zibar, Darko;

    2011-01-01

    We propose a product code with shortened BCH component codes for 100G optical communication systems. Simulation result shows that 10 dB net coding gain is promising at post- FEC BER of 1E-15.......We propose a product code with shortened BCH component codes for 100G optical communication systems. Simulation result shows that 10 dB net coding gain is promising at post- FEC BER of 1E-15....

  10. EFFECTS OF CHANGES IN HIP POSITION ON ACTIONS OF SPINAL INHIBITORY INTERNEURONS IN HUMANS

    OpenAIRE

    Knikou, Maria

    2006-01-01

    The aim of the present study was to establish whether in healthy human subjects the actions of group I muscle afferents arising from the same spinal segments as the soleus innervation (e.g., common peroneal nerve; CPN) or from more proximal spinal segments (femoral nerve; FN) on the soleus H-reflex are modified by changes in hip position. Control and conditioned soleus H-reflexes were elicited and recorded via conventional methods. In seated subjects, CPN and FN stimulation resulted in simila...

  11. Antimicrobial compounds targeting Gram-negative bacteria in food: Their mode of action and combinational effects

    DEFF Research Database (Denmark)

    Hyldgaard, Morten

    2015-01-01

    compromising food shelf-life or safety. Natural antimicrobial compounds have therefore gained increased interest as a label-friendly alternative that can be added directly to food products. Although natural antimicrobials constitute an interesting source of compounds, it is often not understood how...... projects concerning the efficiency of combining natural antimicrobial agents in vitro or in a food matrix. In the first project, the action mechanism behind the natural antimicrobial cationic biopolymer ε-poly-L-lysine was studied against the Gram-positive Listeria innocua and the Gram-negative Escherichia...

  12. Effect of low-frequency electrical stimulation parameters on its anticonvulsant action during rapid perforant path kindling in rat.

    Science.gov (United States)

    Shahpari, Marzieh; Mirnajafi-Zadeh, Javad; Firoozabadi, Seyed Mohammad P; Yadollahpour, Ali

    2012-03-01

    Low frequency stimulation (LFS) may be considered as a new potential therapy for drug-resistant epilepsy. However, the relation between LFS parameters and its anticonvulsant effects is not completely determined. In this study, the effect of some LFS parameters on its anticonvulsant action was investigated in rats. In all animals, stimulating and recording electrodes were implanted into the perforant path and dentate gyrus, respectively. In one group of animals, kindling stimulations were applied until rats achieved a fully kindled state. In other groups, different patterns of LFS were applied at the end of kindling stimulations during twenty consecutive days. In the first experiment the effect of LFS pulse numbers was investigated on its anticonvulsant action. Animals were divided randomly into three groups and 1, 4, and 8 packages of LFS (each pack contains 200 pulses, 0.1 ms pulse duration at 1 Hz) were applied five minutes after termination of kindling stimulations. Obtained results showed that 4 packages of LFS had the strongest anticonvulsant effects. Therefore, this pattern (4 packages) was used in the next experiment. In the second experiment, 4 packages of LFS were applied at intervals of 30 s and 30 min after termination of kindling stimulations. The strongest anticonvulsant effect was observed in the group received LFS at the interval of 30 s. Therefore, this pattern was selected for the third experiment. In the third experiment the effect of LFS at frequencies of 0.25 Hz and 5 Hz was investigated. The group of animals which received LFS at the frequency of 0.25 Hz showed somehow stronger anticonvulsant effect. The results indicate that different parameters of LFS have important role in induction of LFS anticonvulsant effects. Regarding this view, it seems that the slower LFS frequency and the shorter interval between LFS and kindling stimulations, the stronger anticonvulsant effect will be observed. But there is no direct relation between number of

  13. Action physics

    Science.gov (United States)

    McGinness, Lachlan P.; Savage, C. M.

    2016-09-01

    More than a decade ago, Edwin Taylor issued a "call to action" that presented the case for basing introductory university mechanics teaching around the principle of stationary action [E. F. Taylor, Am. J. Phys. 71, 423-425 (2003)]. We report on our response to that call in the form of an investigation of the teaching and learning of the stationary action formulation of physics in a first-year university course. Our action physics instruction proceeded from the many-paths approach to quantum physics to ray optics, classical mechanics, and relativity. Despite the challenges presented by action physics, students reported it to be accessible, interesting, motivational, and valuable.

  14. Joint action of a pair of rowers in a race: Shared experiences of effectiveness are shaped by interpersonal mechanical states

    Directory of Open Access Journals (Sweden)

    Mehdi eR'kiouak

    2016-05-01

    Full Text Available The purpose of this study was to understand how a single pair of expert individual rowers experienced their crew functioning in natural conditions when asked to practice a joint movement for the first time. To fulfill this objective, we conducted a field study of interpersonal coordination that combined phenomenological and mechanical data from a coxless pair activity, to analyze the dynamics of the (intersubjective experience compared with the dynamics of the team coordination. Using an enactivist approach to social couplings, these heterogeneous data were combined to explore the salience (and accuracy of individuals’ shared experiences of their joint action. First, we determined how each rower experienced the continuous crew functioning states (e.g., feelings of the boat’s glide. Second, the phenomenological data helped us to build several categories of oar strokes (i.e., cycles, experienced by the rowers as either detrimentally or effectively performed strokes. Third, the mechanical signatures that correlated with each phenomenological category were tracked at various level of organization (i.e., individual-, interpersonal-, and boat-levels. The results indicated that (a the two rowers did not pay attention to their joint action during most of the cycles, (b some cycles were simultaneously lived as a salient, meaningful experience of either a detrimental (n= 15 cycles or an effective (n=18 cycles joint action, and (c the mechanical signatures diverged across the delineated phenomenological categories, suggesting that the way in which the cycles were experienced emerged from the variance in some mechanical parameters (i.e., differences in peak force level and mean force. Notably, the mechanical measures that helped to explain differences within the phenomenological categories were found at the interpersonal level of analysis, thus suggesting an intentional inter-personal mode of regulation of their joint action. This result is further

  15. Exploring perception-action relations in music production: The asymmetric effect of tonal class.

    Science.gov (United States)

    Jebb, Andrew T; Pfordresher, Peter Q

    2016-05-01

    When playing musical passages, performers integrate the pitch content of auditory feedback with current action plans. However, this process depends on the degree to which the musical structure of the feedback melody is perceived as similar to the structure of what is planned. Four experiments reported here explored the relationship between the tonal class of planned melodies (tonal or atonal) and the sequence of events formed by auditory feedback. Participants produced short melodies from memory that were either tonal (Experiments 1 and 3) or atonal (Experiments 2 and 4). Auditory feedback matched the planned melody with respect to contour but could vary in tonal class. The results showed that when participants planned a tonal melody, atonal feedback was treated as unrelated to the planned sequence. However, when planning an atonal melody, tonal feedback was still treated as similar to the planned sequence. This asymmetric similarity mirrors findings found within the music perception literature and implies that schematic musical knowledge is highly active in determining perception-action relations during music performance. PMID:26594878

  16. Deleterious effects of lard-enriched diet on tissues fatty acids composition and hypothalamic insulin actions.

    Science.gov (United States)

    Dornellas, A P S; Watanabe, R L H; Pimentel, G D; Boldarine, V T; Nascimento, C M O; Oyama, L M; Ghebremeskel, K; Wang, Y; Bueno, A A; Ribeiro, E B

    2015-12-01

    Altered tissue fatty acid (FA) composition may affect mechanisms involved in the control of energy homeostasis, including central insulin actions. In rats fed either standard chow or a lard-enriched chow (high in saturated/low in polyunsaturated FA, HS-LP) for eight weeks, we examined the FA composition of blood, hypothalamus, liver, and retroperitoneal, epididymal and mesenteric adipose tissues. Insulin-induced hypophagia and hypothalamic signaling were evaluated after intracerebroventricular insulin injection. HS-LP feeding increased saturated FA content in adipose tissues and serum while it decreased polyunsaturated FA content of adipose tissues, serum, and liver. Hypothalamic C20:5n-3 and C20:3n-6 contents increased while monounsaturated FA content decreased. HS-LP rats showed hyperglycemia, impaired insulin-induced hypophagia and hypothalamic insulin signaling. The results showed that, upon HS-LP feeding, peripheral tissues underwent potentially deleterious alterations in their FA composition, whist the hypothalamus was relatively preserved. However, hypothalamic insulin signaling and hypophagia were drastically impaired. These findings suggest that impairment of hypothalamic insulin actions by HS-LP feeding was not related to tissue FA composition. PMID:26525379

  17. Effects of ionizing-radiation and post-radiation action of some plant growth regulators on the seed germination and seedling growth of Scotch pine

    Directory of Open Access Journals (Sweden)

    Leszek Michalski

    2015-05-01

    Full Text Available The effects of small doses of gamma irradiation on the seed germination and seedling growth of Scotch pine and post-radiation action of water solutions of IAA, GA3 and kinetin have been investigated. Changes in the destructive action of ionizing-radiation toy gibberellic acid and its intensifying by IAA and kinetin has been found.

  18. Differential Cross Sections for the H + D2 → HD(v' = 3, j' = 4-10) + D Reaction above the Conical Intersection.

    Science.gov (United States)

    Gao, Hong; Sneha, Mahima; Bouakline, Foudhil; Althorpe, Stuart C; Zare, Richard N

    2015-12-17

    We report rovibrationally selected differential cross sections (DCSs) of the benchmark reaction H + D2 → HD(v' = 3, j' = 4-10) + D at a collision energy of 3.26 eV, which exceeds the conical intersection of the H3 potential energy surface at 2.74 eV. We use the PHOTOLOC technique in which a fluorine excimer laser at 157.64 nm photodissociates hydrogen bromide (HBr) molecules to generate fast H atoms and the HD product is detected in a state-specific manner by resonance-enhanced multiphoton ionization. Fully converged quantum wave packet calculations were performed for this reaction at this high collision energy without inclusion of the geometric phase (GP) effect, which takes into account coupling to the first excited state of the H3 potential energy surface. Multimodal structures can be observed in most of the DCSs up to j' = 10, which is predicted by theory and also well-reproduced by experiment. The theoretically calculated DCSs are in good overall agreement with the experimental measurements, which indicates that the GP effect is not large enough that its existence can be verified experimentally at this collision energy. PMID:26090780

  19. Action Effects and Task Knowledge: The Influence of Anticipatory Priming on the Identification of Task-Related Stimuli in Experts.

    Directory of Open Access Journals (Sweden)

    William M Land

    Full Text Available The purpose of the present study was to examine the extent to which anticipation of an action's perceptual effect primes identification of task-related stimuli. Specifically, skilled (n = 16 and novice (n = 24 tennis players performed a choice-reaction time (CRT test in which they identified whether the presented stimulus was a picture of a baseball bat or tennis racket. Following their response, auditory feedback associated with either baseball or tennis was presented. The CRT test was performed in blocks in which participants predictably received the baseball sound or tennis sound irrespective of which stimulus picture was displayed. Results indicated that skilled tennis players responded quicker to tennis stimuli when the response was predictably followed by the tennis auditory effect compared to the baseball auditory effect. These findings imply that, within an individual's area of expertise, domain-relevant knowledge is primed by anticipation of an action's perceptual effect, thus allowing the cognitive system to more quickly identify environmental information. This finding provides a more complete picture of the influence that anticipation can have on the cognitive-motor system. No differences existed for novices.

  20. Concentration addition, independent action and generalized concentration addition models for mixture effect prediction of sex hormone synthesis in vitro

    DEFF Research Database (Denmark)

    Hadrup, Niels; Taxvig, Camilla; Pedersen, Mikael;

    2013-01-01

    of the concentration addition (CA), independent action (IA) and generalized concentration addition (GCA) models. First we measured effects of single chemicals and mixtures thereof on steroid synthesis in H295R cells. Then single chemical data were applied to the models; predictions of mixture effects were calculated......, for which the models could not be applied, was identified. In addition, the data indicate that in non-potency adjusted mixtures the effects cannot always be accounted for by single chemicals.......Humans are concomitantly exposed to numerous chemicals. An infinite number of combinations and doses thereof can be imagined. For toxicological risk assessment the mathematical prediction of mixture effects, using knowledge on single chemicals, is therefore desirable. We investigated pros and cons...

  1. Local Actions in the Post-carbon Transition: A Simulation of the Macroeconomic Effects

    International Nuclear Information System (INIS)

    In 2009 a programme -'Re-thinking Society in a Post-carbon Society'- steered jointly by the Foresight Department of the French Ecology Ministry and the French Environment and Energy Management Agency (ADEME), was launched in France. It is still ongoing and aims to produce a final report in 2013. The idea of a transition towards a 'post- carbon' society includes four main objectives: reducing greenhouse gas emissions by 2050 to one quarter of what they were in 1990; near-autonomy with regard to carbon energies (petrol, gas, coal); an adequate capacity to adapt to climate change and, lastly, greater attention to situations of 'energy precariousness'. As part of the dossier Futuribles is devoting to this programme this month, Cedric Allio, Henri Waisman and Jean-Charles Hourcade present here the study carried out by CIRED (International Research Center on Environment and Development) on the role played by local action in the post-carbon transition . The authors begin by reminding us of the importance of the transport sector in the increase in energy demand and in greenhouse gas emissions, and the need to bring about significant changes in individuals' mobility behaviours if a post-carbon transition on a substantial scale is to be achieved. To do this, local initiatives could be crucial, given their impact on the spatial organization of territories, and could complement the measures put in place at higher levels (national, European or global). This is what clearly emerges from the model developed by CIRED to study the interactions between local and global levels in the post-carbon transition and to provide a macro-economic frame for the scenarios envisaged in the 'Post-carbon Cities' programme. The authors offer a comparison of two scenarios for reducing greenhouse gas emissions by half by 2050, but doing so by very different transition processes, and they show how, in these two contexts, local and global actions are interconnected and how that connection and a correct

  2. Deformation of a laser plasma corona under the action of a ponderomotive force and accompanying effects

    International Nuclear Information System (INIS)

    The pattern of deformation of the density profile of an inhomogeneous laser plasma flow due to the action of a ponderomotive force is identified. The dynamic pattern of generation of non-linear potential fields in the plasma, including caviton-trapped fields, is demonstrated. By isolating the dissipative mechanisms, it was possible to determine the proportion of the energy dissipated in the plasma as a result of the Cherenkov mechanism of interaction between the potential fields and electrons, and thus, the energy which results in the generation of hot electrons. It was shown that a comparatively low plasma flow rate qualitatively alters the pattern of interaction between laser radiation and a plasma. In particular, the formation of cavitons is impeded, the generation of short-wavelength longitudinal fields is suppressed, and the proportion of electromagnetic radiation energy absorbed as a result of the Cherenkov interaction is reduced, i.e., the energy transferred to the fast electrons is reduced. (author)

  3. The effect of action video game playing on sensorimotor learning: Evidence from a movement tracking task.

    Science.gov (United States)

    Gozli, Davood G; Bavelier, Daphne; Pratt, Jay

    2014-10-12

    Research on the impact of action video game playing has revealed performance advantages on a wide range of perceptual and cognitive tasks. It is not known, however, if playing such games confers similar advantages in sensorimotor learning. To address this issue, the present study used a manual motion-tracking task that allowed for a sensitive measure of both accuracy and improvement over time. When the target motion pattern was consistent over trials, gamers improved with a faster rate and eventually outperformed non-gamers. Performance between the two groups, however, did not differ initially. When the target motion was inconsistent, changing on every trial, results revealed no difference between gamers and non-gamers. Together, our findings suggest that video game playing confers no reliable benefit in sensorimotor control, but it does enhance sensorimotor learning, enabling superior performance in tasks with consistent and predictable structure. PMID:25318081

  4. Propeller effect in action in the ultraluminous accreting magnetar M82 X-2

    CERN Document Server

    Tsygankov, Sergey S; Suleimanov, Valery F; Poutanen, Juri

    2015-01-01

    We present here the first convincing observational manifestation of a magnetar-like magnetic field in an accreting neutron star in binary system - the first pulsating ultra-luminous X-ray source X-2 in the galaxy M82. Using the Chandra X-ray observatory data we show that the source exhibit the bimodal distribution of the luminosity with two well-defined peaks separated by a factor of 40. This behaviour can be interpreted as the action of the "propeller regime" of accretion. The onset of the propeller in a 1.37 s pulsar at luminosity of ~$10^{40}$ erg/s implies the dipole component of the neutron star magnetic field of ~$10^{14}$ G.

  5. Is a generalized NJL model the effective action of massless QCD?

    CERN Document Server

    de Oca, Alejandro Cabo Montes

    2015-01-01

    A local and gauge invariant alternative version of QCD for massive fermions introduced in previous works, is considered here to just propose a theory which includes Nambu-Jona-Lasinio (NJL) terms in its defining action in a renormalizable form. The Lagrangian includes a special kind of new vertices which at first sight, look as breaking power counting renormalizability. However, these terms also modify the quark propagators, to become more decreasing that the Dirac propagator at large momenta, indicating that the theory is renormalizable. Therefore, it follows the surprising conclusion that the added NJL four fermions terms does not break renormalizability. The approach, can also be interpreted as a slightly generalized renormalization procedure for massless QCD, which seems able to incorporate the mass generating properties for the quarks of the NJL model, in a renormalizable way. The structure of the free propagator, given by the substraction between a massive and a massless Dirac one in the Lee-Wick form, ...

  6. The effect of action video game playing on sensorimotor learning: Evidence from a movement tracking task.

    Science.gov (United States)

    Gozli, Davood G; Bavelier, Daphne; Pratt, Jay

    2014-10-12

    Research on the impact of action video game playing has revealed performance advantages on a wide range of perceptual and cognitive tasks. It is not known, however, if playing such games confers similar advantages in sensorimotor learning. To address this issue, the present study used a manual motion-tracking task that allowed for a sensitive measure of both accuracy and improvement over time. When the target motion pattern was consistent over trials, gamers improved with a faster rate and eventually outperformed non-gamers. Performance between the two groups, however, did not differ initially. When the target motion was inconsistent, changing on every trial, results revealed no difference between gamers and non-gamers. Together, our findings suggest that video game playing confers no reliable benefit in sensorimotor control, but it does enhance sensorimotor learning, enabling superior performance in tasks with consistent and predictable structure.

  7. Improving regulatory effectiveness in federal/state siting actions: water supplies and the nuclear licensing process

    International Nuclear Information System (INIS)

    The Interstate Conference on Water Problems (ICWP) is a national association of State, intrastate, and interstate officials concerned with water resources administration and related matters. The Conference was established in 1959 as an outgrowth of regional conferences on water problems as recognized in the same year by action of the General Assembly of the States. This report was produced by the Interstate Conference on Water Problems in an effort to provide a compilation and summary of the views of selected States regarding relationships of water supplies to the nuclear power plant licensing process. This publication does not represent the official position of the U.S Water Resources Council, or the U.S. Nuclear Regulatory Commission, nor does it represent the position of any single state or the ICWP

  8. Propeller effect in action in the ultraluminous accreting magnetar M82 X-2

    Science.gov (United States)

    Tsygankov, Sergey S.; Mushtukov, Alexander A.; Suleimanov, Valery F.; Poutanen, Juri

    2016-03-01

    We present here the first convincing observational manifestation of a magnetar-like magnetic field in an accreting neutron star in binary system - the first pulsating ultraluminous X-ray source X-2 in the galaxy M82. Using the Chandra X-ray observatory data, we show that the source exhibit the bimodal distribution of the luminosity with two well-defined peaks separated by a factor of 40. This behaviour can be interpreted as the action of the `propeller regime' of accretion. The onset of the propeller in a 1.37 s pulsar at luminosity of ˜1040 erg s-1 implies the dipole component of the neutron star magnetic field of ˜1014 G.

  9. Identification of Effects of Regulatory Actions on Air Quality in Goods Movement Corridors in California.

    Science.gov (United States)

    Su, Jason G; Meng, Ying-Ying; Pickett, Melissa; Seto, Edmund; Ritz, Beate; Jerrett, Michael

    2016-08-16

    Few studies have assessed the impact of regulatory actions on air quality improvement through a comprehensive monitoring effort. In this study, we designed saturation sampling of nitrogen oxides (NOX) for the counties of Los Angeles and Alameda (San Francisco Bay) before (2003-2007) and after (2008-2013) implementation of goods movement actions in California. We further separated the research regions into three location categories, including goods movement corridors (GMCs), nongoods movement corridors (NGMCs), and control areas (CTRLs). Linear mixed models were developed to identify whether reductions in NOX were greater in GMCs than in other areas, after controlling for potential confounding, including weather conditions (e.g., wind speed and temperature) and season of sampling. We also considered factors that might confound the relationship, including traffic and cargo volumes that may have changed due to economic downturn impacts. Compared to the pre-policy period, we found reductions of average pollutant concentrations for nitrogen dioxide (NO2) and NOX in GMCs of 6.4 and 21.7 ppb. The reductions were smaller in NGMCs (5.9 and 16.3 ppb, respectively) and in CTRLs (4.6 and 12.1 ppb, respectively). After controlling for potential confounding from weather conditions, season of sampling, and the economic downturn in 2008, the linear mixed models demonstrated that reductions in NO2 and NOX were significantly greater in GMCs compared to reductions observed in CTRLs; there were no statistically significant differences between NGMCs and CTRLs. These results indicate that policies regulating goods movement are achieving the desired outcome of improving air quality for the state, particularly in goods movement corridors where most disadvantaged communities live. PMID:27380254

  10. On D-brane anti D-brane effective actions and their corrections to all orders in alpha-prime

    Energy Technology Data Exchange (ETDEWEB)

    Hatefi, Ehsan, E-mail: ehatefi@ictp.it [International Centre for Theoretical Physics, Strada Costiera 11, Trieste (Italy)

    2013-09-01

    Based on a four point function, the S-matrix elements at disk level of the scattering amplitude of one closed string Ramond-Ramond field (C) and two tachyons and one scalar field, we find out new couplings in brane anti brane effective actions for p = n, p+2 = n cases. Using the infinite corrections of the vertex of one RR, one gauge and one scalar field and applying the correct expansion, it is investigated in detail how we produce the infinite gauge poles of the amplitude for p = n case. By discovering new higher derivative corrections of two tachyon-two scalar couplings in brane anti brane systems to all orders in α', we also obtain the infinite scalar poles in (t'+s'+u)-channel in field theory. Working with the complete form of the amplitude with the closed form of the expansion and comparing all the infinite contact terms of this amplitude, we derive several new Wess-Zumino couplings with all their infinite higher derivative corrections in the world volume of brane anti brane systems. In particular, in producing all the infinite scalar poles of < V{sub C}V{sub φ}V{sub T}V{sub T} > , one has to consider the fact that scalar's vertex operator in (-1)-picture must carry the internal σ{sub 3} Chan-Paton matrix. The symmetric trace effective action has a non-zero coupling between Dφ{sup (1)i} and Dφ{sup (2)}{sub i} while this coupling does not exist in ordinary trace effective action.

  11. Research on the influence of action between fin and anti-rolling tank on the integrated stabilization effect

    Institute of Scientific and Technical Information of China (English)

    YU Li-jun; JIN Hong-zhang; WANG Hui; YANG Sheng

    2007-01-01

    Through analyzing the roll model of the integrated system of fin and anti-rolling tank, this paper uses binomial equation to simplify the module and check how the approximate parameters simulate the original function. Based on the simplified module, the influence of fin and anti-rolling tank on the coefficient items of the roll module is discussed, and the influencing factors between fin and anti-rolling tank are analysed. And through simulation, the influence of action between fin and anti-rolling tank on the static characteristics, and the integrated stabilization effect, are analyzed.

  12. Effects of rapid and slow potassium repolarization currents and calcium dynamics on hysteresis in restitution of action potential duration.

    Science.gov (United States)

    Wu, Runze; Patwardhan, Abhijit

    2007-04-01

    We used a mathematical model to investigate effects of repolarizing currents I(kr) and I(ks), calcium (Ca) current I(CaL), and Ca dynamics in network sarcoplasmic reticulum and junctional sarcoplasmic reticulum (JSR) on hysteresis in restitution of action potential duration. Enhanced I(kr) increased slope of restitution, hysteresis loop thickness, and delay between peaks of diastolic intervals and action potential duration. Increase in I(ks) decreased loop thickness and peak delay. Decrease in I(CaL) had effects similar to increasing I(kr), except slope of restitution decreased markedly. Uptake of Ca into the network sarcoplasmic reticulum had less effect on hysteresis than transfer of Ca into JSR. Faster transfer of Ca into JSR markedly decreased loop thickness and peak delay. Our results provide insight into mechanisms responsible for this newly identified property of restitution. Such information will be valuable in studies where modification of hysteresis is used to investigate its role in arrhythmogenesis. PMID:16895773

  13. The sunk cost effect across species: A review of persistence in a course of action due to prior investment.

    Science.gov (United States)

    Magalhães, Paula; Geoffrey White, K

    2016-05-01

    The sunk cost effect is the bias or tendency to persist in a course of action due to prior investments of effort, money or time. At the time of the only review on the sunk cost effect across species (Arkes & Ayton, 1999), research with nonhuman animals had been ecological in its nature, and the findings about the effect of past investments on current choice were inconclusive. However, in the last decade a new line of experimental laboratory-based research has emerged with the promise of revolutionizing the way we approach the study of the sunk cost effect in nonhumans. In the present review we challenge Arkes and Ayton's conclusion that the sunk cost effect is exclusive to humans, and describe evidence for the sunk cost effect in nonhuman animals. By doing so, we also challenge the current explanations for the sunk cost effect in humans, as they are not applicable to nonhumans. We argue that a unified theory is called for, because different independent variables, in particular, investment amount, have the same influence on the sunk cost effect across species. Finally, we suggest possible psychological mechanisms shared across different species, contrast and depreciation, that could explain the sunk cost effect. PMID:27151560

  14. Optomechanical effects of two-level systems in a back-action evading measurement of micro-mechanical motion

    Science.gov (United States)

    Suh, J.; Weinstein, A. J.; Schwab, K. C.

    2013-07-01

    We show that the two-level systems (TLS) in lithographic superconducting circuits act as a power-dependent dielectric leading to non-linear responses in a parametrically coupled electromechanical system. Driven TLS shift the microwave resonance frequency and modulate the mechanical resonance through the optical spring effect. By pumping with two tones in a back-action evading measurement, these effects produce a mechanical parametric instability which limits single quadrature imprecision to 1.4 xzp. The microwave resonator noise is also consistent to a TLS-noise model. These observations suggest design strategies for minimizing TLS effects to improve ground-state cooling and quantum non-demolition measurements of motion.

  15. Optomechanical effects of two-level systems in a back-action evading measurement of micro-mechanical motion

    International Nuclear Information System (INIS)

    We show that the two-level systems (TLS) in lithographic superconducting circuits act as a power-dependent dielectric leading to non-linear responses in a parametrically coupled electromechanical system. Driven TLS shift the microwave resonance frequency and modulate the mechanical resonance through the optical spring effect. By pumping with two tones in a back-action evading measurement, these effects produce a mechanical parametric instability which limits single quadrature imprecision to 1.4 xzp. The microwave resonator noise is also consistent to a TLS-noise model. These observations suggest design strategies for minimizing TLS effects to improve ground-state cooling and quantum non-demolition measurements of motion

  16. The Antihyperglycemic Effects of Rhizoma Coptidis and Mechanism of Actions: A Review of Systematic Reviews and Pharmacological Research

    Directory of Open Access Journals (Sweden)

    Hui Wang

    2014-01-01

    Full Text Available Rhizoma Coptidis (Huang Lian in Chinese pinyin is among the most widely used traditional Chinese herbal medicines and has a profound history of more than 2000 years of being used as a therapeutic herb. The antidiabetic effects of Rhizoma Coptidis have been extensively investigated in animal experiments and clinical trials and its efficacy as a promising antihyperglycemic agent has been widely discussed. In the meantime, findings from modern pharmacological studies have contributed the majority of its bioactivities to berberine, the isoquinoline alkaloids component of the herb, and a number of experiments testing the antidiabetic effects of berberine have been initiated. Therefore, we conducted a review of the current evidence profile of the antihyperglycemic effects of Rhizoma Coptidis as well as its main component berberine and the possible mechanism of actions, in order to summarize research evidence in this area and identify future research directions.

  17. Radiative Contributions to the Effective Action of Self-Interacting Scalar Field on a Manifold with Boundary

    CERN Document Server

    Tsoupros, G

    2000-01-01

    The effect of quantum corrections to a conformally invariant field theory for a self-interacting scalar field on a curved manifold with boundary is considered. The analysis is most easily performed in a space of constant curvature the boundary of which is characterised by constant extrinsic curvature. An extension of the spherical formulation in the presence of a boundary is attained through use of the method of images. Contrary to the consolidated vanishing effect in maximally symmetric space-times the contribution of the massless "tadpole" diagram no longer vanishes in dimensional regularisation. As a result, conformal invariance is broken due to boundary-related vacuum contributions. The evaluation of one-loop contributions to the two-point function suggests an extension, in the presence of matter couplings, of the simultaneous volume and boundary renormalisation in the effective action.

  18. The effectiveness of community action in reducing risky alcohol consumption and harm: a cluster randomised controlled trial.

    Directory of Open Access Journals (Sweden)

    Anthony Shakeshaft

    2014-03-01

    Full Text Available BACKGROUND: The World Health Organization, governments, and communities agree that community action is likely to reduce risky alcohol consumption and harm. Despite this agreement, there is little rigorous evidence that community action is effective: of the six randomised trials of community action published to date, all were US-based and focused on young people (rather than the whole community, and their outcomes were limited to self-report or alcohol purchase attempts. The objective of this study was to conduct the first non-US randomised controlled trial (RCT of community action to quantify the effectiveness of this approach in reducing risky alcohol consumption and harms measured using both self-report and routinely collected data. METHODS AND FINDINGS: We conducted a cluster RCT comprising 20 communities in Australia that had populations of 5,000-20,000, were at least 100 km from an urban centre (population ≥ 100,000, and were not involved in another community alcohol project. Communities were pair-matched, and one member of each pair was randomly allocated to the experimental group. Thirteen interventions were implemented in the experimental communities from 2005 to 2009: community engagement; general practitioner training in alcohol screening and brief intervention (SBI; feedback to key stakeholders; media campaign; workplace policies/practices training; school-based intervention; general practitioner feedback on their prescribing of alcohol medications; community pharmacy-based SBI; web-based SBI; Aboriginal Community Controlled Health Services support for SBI; Good Sports program for sports clubs; identifying and targeting high-risk weekends; and hospital emergency department-based SBI. Primary outcomes based on routinely collected data were alcohol-related crime, traffic crashes, and hospital inpatient admissions. Routinely collected data for the entire study period (2001-2009 were obtained in 2010. Secondary outcomes based on pre

  19. Potential effect and mechanism of action of topical chamomile (Matricaria chammomila L.) oil on migraine headache: A medical hypothesis.

    Science.gov (United States)

    Zargaran, Arman; Borhani-Haghighi, Afshin; Faridi, Pouya; Daneshamouz, Saeid; Kordafshari, Gholamreza; Mohagheghzadeh, Abdolali

    2014-11-01

    Migraine is a chronic recurring headache for which no complete treatment has been found yet. Therefore, finding new treatment approaches and medicines is important. In this review, we consider the probable mechanism of action of a traditional and ethnic formulary of chamomile extract in sesame oil as a new topical medication for migraine pain relief. Chamomile oil is prepared in Traditional Persian Medicine by boiling aqueous extract of chamomile in sesame oil. To optimize the procedure, we can use a Clevenger-type apparatus to extract the essential oil and add it to the end product. The preparation includes both essential oils (chamazulene and bisabolol oxide) and polyphenols (a flavonoid such as apigenin and its derivatives). It probably possesses pain relief effects for migraines because of the following properties: (1) chamazulene and apigenin, which inhibit iNOS expression in activated macrophages and can lead to the prohibition of NO release and synthesis; (2) chamomile flavonoids, which have a strong inhibitory effect on endogenous prostaglandin E2 (PGE2) levels in RAW 264.7 macrophages and can play the role of selective COX-2 inhibitor; (3) chamomile polyphenols, which possess anti-inflammatory effects due to the inhibition of pro-inflammatory biomarkers in THP1 macrophages and which can reduce inflammation in neurovascular units (NVU) at the site of migraine pain; (4) chamomile, which has neuroprotective effects because of reduced NO levels; (5) sesamine in sesame oil, which possesses an anti-inflammatory effect. These effects are supported by main pathophysiological theories of migraine such as neural and sensitization theories. Chamomile oil is a traditional formulation still used in Iran as an ethno-medicine. Because of the mentioned mechanisms of action, it can be hypothesized that chamomile oil is a novel medicine for the relief of migraine pain. PMID:25238714

  20. EFFECTS OF DESENSITIZATION AND REBOUND TO ADENOSINE ON ACTION POTENTIAL AND CONTRACTILITY IN ATRIAL CELLS IN GUINEA-PIGS

    Institute of Scientific and Technical Information of China (English)

    张凤杰; 臧伟进; 于晓江; 胡浩; 张春虹; 孙强; 吕军

    2002-01-01

    Objective To investigate the effects of desensitization and rebound to adenosine(Ado) on action potential duration(APD) and contractility in guinea-pig atrial cells. Methods Electrical activity was recorded using standard intracellular microelectrode technique and contractility was recorded using. We studied the effects of adenosine on the action potential and desensitization of contractility and rebound of contractility. Results The results showed that action potential duration were shortened by 1,10,100μmol*L-1Ado, the ratio of shortened APD was (9.58±1.40)%,(13.80±2.26)%,(24.80±3.19)%, respectively. 1μmol*L-1Ado had no desensitization (P>0.05), but the time of desensitization of 10μmol*L-1 Ado and 100μmol*L-1 Ado was 1 minute(P<0.05) and 5 minutes(P<0.05), respectively. The desensitization of contractility of 10*!μmol*L-1 Ado was obvious in atrial cells, the decrease of contractility of 10*!μmol*L-1 Ado was obvious in atrial cells, the decrease of contractility was changed from (31.4±16.04)%(2 minutes) to (50.60±15.87)% (4 minutes), compared with control. After washing out Ado, contractility was shown to rebound, the ratio of increase of contractility by 1,10,100μmol*L-1 Ado was (12.38±7.50)%,(19.00±8.14)% and (27.60±13.44)%, respectively. Conclusion Ado can abbreviate APD in atrial cells. The desensitization of Ado on APD is characterized by concentration-dependent and time-dependent in atrial cells, and the desensitization of contractility of Ado is obvious and contractility was shown to rebound after washing out Ado.

  1. Protective effects of steroidal alkaloids isolated from Solanum paniculatum L. against mitomycin cytotoxic and genotoxic actions

    Directory of Open Access Journals (Sweden)

    PABLINE M. VIEIRA

    2013-06-01

    Full Text Available Solanum paniculatum L. is a plant species widespread throughout tropical America, especially in the Brazilian Cerrado region. It is used in Brazil for culinary purposes and in folk medicine to treat liver and gastric dysfunctions, as well as hangovers. Previous studies with S. paniculatum ethanolic leaf extract or ethanolic fruit extract demonstrated that they have no genotoxic activity neither in mice nor in bacterial strains, although their cytotoxicity and antigenotoxicity were demonstrated in higher doses. In order to assess the possible compounds responsible for the activities observed, we fractionated the ethanolic fruit extract of S. paniculatum, characterized by 1H and 13C NMR spectra, and evaluated two fractions containing steroidal alkaloids against mitomycin C (MMC using the mouse bone marrow micronucleus test. Swiss mice were orally treated with different concentrations (25, 50, or 100 mg.kg−1 of each fraction simultaneously with a single intraperitonial dose of MMC (4 mg.kg−1. Antigenotoxicity was evaluated by using the frequency of micronucleated polychromatic erythrocytes (MNPCE, whereas anticytotoxicity was assessed by the polychromatic and normochromatic erythrocytes ratio (PCE/NCE. Our results demonstrated that steroidal alkaloids isolated from S. paniculatum strongly protected cells against MMC aneugenic and/or clastogenic activities as well as modulated MMC cytotoxic action.

  2. Somatosensory effects of action inhibition: a study with the stop-signal paradigm.

    Science.gov (United States)

    Walsh, Eamonn; Haggard, Patrick

    2010-07-01

    When a weak shock is delivered to the finger immediately before a voluntary movement, or during a delay interval where subjects are prepared to make the movement, shock detection rates worsen progressively as the movement approaches. Further, we previously showed that shock detection improves again if a NoGo signal produces inhibition of a prepared response. Here, we used a somatosensory version of the stop-signal paradigm to investigate inhibitory processing during the 'horserace' period when motor excitation and inhibition processes may be simultaneously active. When subjects made a rapid keypress response to a go-signal, shock detection deteriorated in a time-dependent manner, replicating sensory suppression. However, when go-signals were followed by adaptively delayed stop-signals so that subjects could not inhibit the prepared movement, and made errors of commission, we found a paradoxical brief increase in shock detection performance just after the stop-signal, as if in a NoGo trial. During this brief window, the somatosensory system showed a pattern consistent with motor inhibition, even though the motor system itself was too far advanced in movement execution for action to be inhibited. Most models of stop-signal processing propose a two-horse race between excitation and inhibition, with a winner-takes-all solution. We show that there may be distinct motor and somatosensory races. Moreover, inhibitory processes may lead in the somatosensory race, at least briefly, even when excitatory processes win the motor race.

  3. Radiosensitivity of Nicotiana protoplasts. Action on cell; cycle effects of low dose and fractionated irradiations; biological repair

    International Nuclear Information System (INIS)

    Leaf protoplasts of Nicotiana plumbaginifolia and Nicotiana sylvestris demonstrate five main qualities: they can be maintained as haploid lines; they constitute starting populations with a remarkable cytological homogeneity; they show a transient initial lag-phase; they yield very high plating efficiencies and retain permanently a complete differentiation capacity; being derived of a cell wall, they appear well adapted for fusion experiments or enzymatic dosages. The resumption of mitotic activity was followed by cytophotometric measurements, labelling experiments, nuclear sizing and enzymatic assays. The action of 5 Gy gamma-ray irradiations delayed entrance in the S-phase, provoked an otherwise not verified dependency between transcription, translation and protein synthesis, increased nuclear volumes in the G2-phase, and slightly stimulated the activity of a repair enzyme. The plating efficiency was a sensitive end-point which allowed the evaluation of the biological effectiveness of low to medium radiation-doses after gamma-ray and fast neutron irradiations. The neutron dose-RBE relationship increased from 3 to 25 when the dose decreased from 5 Gy to 5 mGy. When fractionated into low single doses only, a neutron dose of 300 mGy markedly increased its biological effectiveness: this phenomenon could not be explained by cell progression, and necessitated additional hypotheses involving other mechanisms in the specific action of low radiation doses. Radiation-induced UDS was measured in presence of aphidicolin. A beta-like DNA-polymerase was shown to be definitely involved in nuclear repair synthesis

  4. Antibacterial Effects and Mode of Action of Selected Essential Oils Components against Escherichia coli and Staphylococcus aureus

    Directory of Open Access Journals (Sweden)

    Julio Cesar Lopez-Romero

    2015-01-01

    Full Text Available Bacterial resistance has been increasingly reported worldwide and is one of the major causes of failure in the treatment of infectious diseases. Natural-based products, including plant secondary metabolites (phytochemicals, may be used to surpass or reduce this problem. The objective of this study was to determine the antibacterial effect and mode of action of selected essential oils (EOs components: carveol, carvone, citronellol, and citronellal, against Escherichia coli and Staphylococcus aureus. The minimum inhibitory concentration (MIC and minimum bactericidal concentration (MBC were assessed for the selected EOs components. Moreover, physicochemical bacterial surface characterization, bacterial surface charge, membrane integrity, and K+ leakage assays were carried out to investigate the antimicrobial mode of action of EOs components. Citronellol was the most effective molecule against both pathogens, followed by citronellal, carveol, and carvone. Changes in the hydrophobicity, surface charge, and membrane integrity with the subsequent K+ leakage from E. coli and S. aureus were observed after exposure to EOs. This study demonstrates that the selected EOs have significant antimicrobial activity against the bacteria tested, acting on the cell surface and causing the disruption of the bacterial membrane. Moreover, these molecules are interesting alternatives to conventional antimicrobials for the control of microbial infections.

  5. The specificity of albumin denaturation on physiological preparations under thermal and gamma-radiation effects (actions)

    International Nuclear Information System (INIS)

    Comparative investigation is performed of the alteration in thin structure of absorption spectra of albumin solutions under thermal and radiation effect resulting in protein denaturation. Gamma radiation effect of 57Co on the preparations of bull and man serum albumins was studied as well as a number of serum preparations. Analysis of the results obtained permits to conclude that different qualitative and quantitative mechanisms of denaturation alterations under the temperature and gamma radiation effects on albumin solutions takes place

  6. Effects of the histamine H1 receptor antagonist hydroxyzine on hERG K+ channels and cardiac action potential duration

    Institute of Scientific and Technical Information of China (English)

    Byung Hoon LEE; Seung Ho LEE; Daehyun CHU; Jin Won HYUN; Han CHOE; Bok Hee CHOI; Su-Hyun JO

    2011-01-01

    To investigate the effects of hydroxyzine on human ether-a-go-go-related gene (hERG) channels to determine the electrolphysiological basis for its proarrhythmic effects.Methods:hERG channels were expressed in Xenopus oocytes and HEK293 cells,and the effects of hydroxyzine on the channels were examined using two-microelectrode voltage-clamp and patch-clamp techniques,respectively.The effects of hydroxyzine on action potential duration were examined in guinea pig ventricular myocytes using current clamp.Results:Hydroxyzine (0.2 and 2 μmol/L) significantly increased the action potential duration at 90% repolarization (APD90) in both concentration- and time-dependent manners.Hydroxyzine (0.03-3 μmol/L) blocked both the steady-state and tail hERG currents.The block was voltage-dependent,and the values of IC50 for blocking the steady-state and tail currents at +20 mV was 0.18±0.02 μmol/L and 0.16±0.01 μmol/L,respectively,in HEK293 cells.Hydroxyzine (5 μmol/L) affected both the activated and the inactivated states of the channels,but not the closed state.The S6 domain mutation Y652A attenuated the blocking of hERG current by ~6-fold.Conclusion:The results suggest that hydroxyzine could block hERG channels and prolong APD.The tyrosine at position 652 in the channel may be responsible for the proarrhythmic effects of hydroxyzine.

  7. Enforcement actions: Significant actions resolved

    International Nuclear Information System (INIS)

    This compilation summarizes significant enforcement actions that have been resolved during one quarterly period (October - December 1993) and includes copies of letters, Notices, and Orders sent by the Nuclear Regulatory Commission to licensees with respect to these enforcement actions. It is anticipated that the information in this publication will be widely disseminated to managers and employees engaged in activities licensed by the NRC, so that actions can be taken to improve safety by avoiding future violations similar to those described in this publication

  8. Enforcement actions: Significant actions resolved

    International Nuclear Information System (INIS)

    This compilation summarizes significant enforcement actions that have been resolved during one quarterly period (July - September 1992) and includes copies of letters, Notices, and Orders sent by the Nuclear Regulatory Commission to licensees with respect to these enforcement actions. It is anticipated that the information in this publication will be widely disseminated to managers and employees engaged in activities licensed by the NRC, so that actions can be taken to improve safety by avoiding future violations similar to those described in this publication

  9. The Hawthorne Misunderstanding (and How to Get the Hawthorne Effect in Action Research).

    Science.gov (United States)

    Gottfredson, Gary D.

    1996-01-01

    Examines the original Hawthorne relay-assembly research. Asserts the "Hawthorne misunderstanding" is common in criminology and criminal justice because authors have failed to properly attribute the explanation of increased work output to the Hawthorne effect. Describes the Hawthorne effect, how it is produced, and ways to achieve the Hawthorne…

  10. Recent State Action on Teacher Effectiveness: What's in State Laws and Regulations?

    Science.gov (United States)

    Mead, Sara

    2012-01-01

    During the 2010, 2011, and 2012 legislative sessions, a combination of federal policy incentives and newly elected governors and legislative majorities in many states following the 2010 elections sparked a wave of legislation addressing teacher effectiveness. More than 20 states passed legislation designed to address educator effectiveness by…

  11. Enforcement actions: Significant actions resolved

    International Nuclear Information System (INIS)

    This compilation summarizes significant enforcement actions that have been resolved during one quarterly period (January--March 1989) and includes copies of letters, Notices, and Orders sent by the Nuclear Regulatory Commission to licensees with respect to these enforcement actions. Also included are a number of enforcement actions that had been previously resolved but not published in this NUREG. It is anticipated that the information in this publication will be widely disseminated to managers and employees engaged in activities licensed by the NRC, so that actions can be taken to improve safety by avoiding future violations similar to those described in this publication

  12. Enforcement actions: Significant actions resolved

    International Nuclear Information System (INIS)

    This compilation summarizes significant enforcement actions that have been resolved during one quarterly period (January--March 1990) and includes copies of letters, Notices, and Orders sent by the Nuclear Regulatory Commission to licensees with respect to these enforcement actions. Also included are a number of enforcement actions that had been previously resolved but not published in this NUREG. It is anticipated that the information in this publication will be widely disseminated to managers and employees engaged in activities licensed by the NRC, so that actions can be taken to improve safety by avoiding future violations similar to those described in this publication

  13. Effect of thermal cutaneous stimulation on the gastric motor activity: Study of the mechanism of action

    Institute of Scientific and Technical Information of China (English)

    Ahmed Shafik; Ali A Shafik; Olfat El Sibai; Ismail A Shafik

    2008-01-01

    AIM: To investigate the mechanism of action of thermal cutaneous stimulation on the gastric motor inhibition.METHODS: The gastric tone of 33 healthy volunteers (20 men, mean age 36.7 ±8.4 years) was assessed by a barostat system consisting of a balloon-ended tube connected to a strain gauge and air-injection system. The tube was introduced into the stomach and the balloon was inflated with 300 mL of air. The skin temperature was elevated in increments of 3℃ up to 49℃ and the gastric tone was simultaneously assessed by recording the balloon volume variations expressed as the percentage change from the baseline volume. The test was repeated after separate anesthetization of the skin and stomach with lidocaine and after using normal saline instead of lidocaine.RESULTS: Thermal cutaneous stimulation resulted in a significant decrease of gastric tone 61.2% ±10.3% of the mean baseline volume. Mean latency was 25.6 ± 1.2 ms.After 20 min of individual anesthetization of the skin and stomach, thermal cutaneous stimulation produced no significant change in gastric tone.CONCLUSION: Decrease in the gastric tone in response to thermal cutaneous stimulation suggests a reflex relationship which was absent on individual anesthetization of the 2 possible arms of the reflex arc:the skin and the stomach. We call this relationship the "cutaneo-gastric inhibitory reflex". This reflex may have the potential to serve as an investigative tool in the diagnosis of gastric motor disorders, provided further studies are performed in this respect.

  14. Conditions for critical effects in the mass action kinetics equations for water radiolysis

    Energy Technology Data Exchange (ETDEWEB)

    Wittman, Richard S.; Buck, Edgar C.; Mausolf, Edward J.; McNamara, Bruce K.; Smith, Frances N.; Soderquist, Chuck Z.

    2014-11-25

    We report on a subtle global feature of the mass action kinetics equations for water radiolysis that results in predictions of a critical behavior in H2O2 and associated radical concentrations. While radiolysis kinetics has been studied extensively in the past, it is only in recent years that high speed computing has allowed the rapid exploration of the solution over widely varying dose and compositional conditions. We explore the radiolytic production of H2O2 under various externally fixed conditions of molecular H2 and O2 that have been regarded as problematic in the literature – specifically, “jumps” in predicted concentrations, and inconsistencies between predictions and experiments have been reported for alpha radiolysis. We computationally map-out a critical concentration behavior for alpha radiolysis kinetics using a comprehensive set of reactions. We then show that all features of interest are accurately reproduced with 15 reactions. An analytical solution for steady-state concentrations of the 15 reactions reveals regions in [H2] and [O2] where the H2O2 concentration is not unique – both stable and unstable concentrations exist. The boundary of this region can be characterized analytically as a function of G-values and rate constants independent of dose rate. Physically, the boundary can be understood as separating a region where a steady-state H2O2 concentration exists, from one where it does not exist without a direct decomposition reaction. We show that this behavior is consistent with reported alpha radiolysis data and that no such behavior should occur for gamma radiolysis. We suggest experiments that could verify or discredit a critical concentration behavior for alpha radiolysis and could place more restrictive ranges on G-values from derived relationships between them.

  15. Conditions for critical effects in the mass action kinetics equations for water radiolysis

    Energy Technology Data Exchange (ETDEWEB)

    Wittman, Richard S.; Buck, Edgar C.; Mausolf, Edward J.; McNamara, Bruce K.; Smith, Frances N.; Soderquist, Chuck Z.

    2014-12-26

    We report on a subtle global feature of the mass action kinetics equations for water radiolysis that results in predictions of a critical behavior in H2O2 and associated radical concentrations. While radiolysis kinetics has been studied extensively in the past, it is only in recent years that high speed computing has allowed the rapid exploration of the solution over widely varying dose and compositional conditions. We explore the radiolytic production of H2O2 under various externally fixed conditions of molecular H2 and O2 that have been regarded as problematic in the literature – specifically, “jumps” in predicted concentrations, and inconsistencies between predictions and experiments have been reported for alpha radiolysis. We computationally map-out a critical concentration behavior for alpha radiolysis kinetics using a comprehensive set of reactions. We then show that all features of interest are accurately reproduced with 15 reactions. An analytical solution for steady-state concentrations of the 15 reactions reveals regions in [H2] and [O2] where the H2O2 concentration is not unique – both stable and unstable concentrations exist. The boundary of this region can be characterized analytically as a function of G-values and rate constants independent of dose rate. Physically, the boundary can be understood as separating a region where a steady-state H2O2 concentration exists, from one where it does not exist without a direct decomposition reaction. We show that this behavior is consistent with reported alpha radiolysis data and that no such behavior should occur for gamma radiolysis. We suggest experiments that could verify or discredit a critical concentration behavior for alpha radiolysis and could place more restrictive ranges on G-values from derived relationships between them.

  16. Advanced Forward Modeling and Inversion of Stokes Profiles Resulting from the Joint Action of the Hanle and Zeeman Effects

    CERN Document Server

    Ramos, A Asensio; Degl'Innocenti, E Landi

    2008-01-01

    A big challenge in solar and stellar physics in the coming years will be to decipher the magnetism of the solar outer atmosphere (chromosphere and corona) along with its dynamic coupling with the magnetic fields of the underlying photosphere. To this end, it is important to develop rigorous diagnostic tools for the physical interpretation of spectropolarimetric observations in suitably chosen spectral lines. Here we present a computer program for the synthesis and inversion of Stokes profiles caused by the joint action of atomic level polarization and the Hanle and Zeeman effects in some spectral lines of diagnostic interest, such as those of the He I 10830 A and D_3 multiplets. It is based on the quantum theory of spectral line polarization, which takes into account all the relevant physical mechanisms and ingredients (optical pumping, atomic level polarization, Zeeman, Paschen-Back and Hanle effects). The influence of radiative transfer on the emergent spectral line radiation is taken into account through a...

  17. OH radicals from the indirect actions of X-rays induce cell lethality and mediate the majority of the oxygen enhancement effect.

    Science.gov (United States)

    Hirayama, Ryoichi; Ito, Atsushi; Noguchi, Miho; Matsumoto, Yoshitaka; Uzawa, Akiko; Kobashi, Gen; Okayasu, Ryuichi; Furusawa, Yoshiya

    2013-11-01

    We examined OH radical-mediated indirect actions from X irradiation on cell killing in wild-type Chinese hamster ovary cell lines (CHO and AA8) under oxic and hypoxic conditions, and compared the contribution of direct and indirect actions under both conditions. The contribution of indirect action on cell killing can be estimated from the maximum degree of protection by dimethylsulfoxide, which suppresses indirect action by quenching OH radicals without affecting the direct action of X rays on cell killing. The contributions of indirect action on cell killing of CHO cells were 76% and 50% under oxic and hypoxic conditions, respectively, and those for AA8 cells were 85% and 47%, respectively. Therefore, the indirect action on cell killing was enhanced by oxygen during X irradiation in both cell lines tested. Oxygen enhancement ratios (OERs) at the 10% survival level (D10 or LD90) for CHO and AA8 cells were 2.68 ± 0.15 and 2.76 ± 0.08, respectively. OERs were evaluated separately for indirect and direct actions, which gave the values of 3.75 and 2.01 for CHO, and 4.11 and 1.32 for AA8 cells, respectively. Thus the generally accepted OER value of ∼3 is best understood as the average of the OER values for both indirect and direct actions. These results imply that both indirect and direct actions on cell killing require oxygen for the majority of lethal DNA damage, however, oxygen plays a larger role in indirect than for direct effects. Conversely, the lethal damage induced by the direct action of X rays are less affected by oxygen concentration.

  18. Clinical evaluation of the cross-action and between teeth toothbrushes effects on the bacterial plaque and gingival status

    Directory of Open Access Journals (Sweden)

    Sayar Ferena

    2015-05-01

    Full Text Available Background and Aims: The routine mechanical plaque control is done by toothbrush. With regard to different designs of tooth head brushes in order to better plaque removal, the aim of this study was to evaluate the effect of between teeth and cross-action tooth brush on the plaque and gingival status among dental students of dental branch-Islamic Azad University during 2012-13 academic years.   Materials and Methods: This single-blind, cross over, clinical trial was conducted on 30 subjects with mean age (23±0.9 in two groups of 15 persons . They had at least 20 teeth and had gingivitis with no history of antibiotic use in the last 3 months. Those who were undergoing orthodontic treatment, using drugs affecting the gums and having crown and bridge were excluded from the study. The first group used the cross action toothbrush and the second group used between teeth toothbrush and the subjects were asked to brush their teeth for two minutes twice a day in modified bass method and not to floss during the execution of this study. After 14 days plaque index (Turesky, Approximal plaque index and gingival bleeding index were recorded on all teeth except third molars. After a week wash out period, second stage of the study was conducted the same as the first stage with the other kind of brush for each group. Data were analyzed using Generalized Linear Model (GLM test.   Results: There was no statistical significant difference between two toothbrushes based on plaque index, gingival bleeding index and approximal plaque index, respectively (P = 0.29, P = 0.47, P = 0.33. In all measured indices, the treatment sequence showed no significant difference (P = 0.23.   Conclusion: There was no statistical difference between cross-action and between teeth toothbrush in reducing plaque and gingival bleeding.

  19. Investigating the effect of clinical governess approach on patients' length of stay in emergency department: an action research study.

    Directory of Open Access Journals (Sweden)

    Tahmine Salehi

    2014-02-01

    Full Text Available Over the past decade, clinical governance approach with aims to improve the quality of health services has been proposed in Iran. Considering the obvious problems especially patients' length of stay (LOS in the emergency departments (EDs; the present study has been carried out with the purpose of Investigating the effect of clinical governess approach on patients' LOS in the one of the largest medical centers in the country. After the problem was specified by the 17 interviews with employees and managers of the ED; the emergency clinical governance committee was formed by two academic researchers and seven ED staff (key participants that had the most involvement with the subject of study. The activities of the committee, including planning, acting, observing and reflecting, was organized by using participatory action research approach and action research cycle (Kemmis 1995. During this time, three formal meetings with key participants were held in 6-month intervals. Monthly records of patients' average LOS and interview with ED staff were used to analyze the findings. The research was completed with two cycles in one year. Committee members took the following actions. As a result, the patients' LOS reduced from 2.68 days to 1.73 days. Make regular patients visits by medical groups especially orthopedists and neurologists; Decision making about patients situation by emergency physicians and transferring patients to the relevant units by bed managers; Refusing to admit elective patients during overcrowding times; to regulate the list of patients requiring ICU by anesthesiologists. Prolonged LOS can be due to various causes and a team approach, which is one of the requirements of clinical governance approach, is needed to manage it. The results showed that the multidisciplinary team could make positive changes and reduce LOS in emergency setting.

  20. Modifying action of gibberellin on the cytogenetic effect of radiation in Crepis capillaris L

    International Nuclear Information System (INIS)

    Radioprotactive properties of gibberellin were studied during treating the Crepic capillaris seeds before irradiation. The radioprotective effect observed did not depend on the interphase stage. Gibberellin was shown to unduce no chromosome mutations

  1. 14 CFR 1216.321 - Environmental effects abroad of major Federal actions.

    Science.gov (United States)

    2010-01-01

    ... participating with or not otherwise involved in the NASA activity; (3) The export of products or facilities... environmental effects on natural and ecological resources of global importance and which the President in...

  2. 21 CFR 25.60 - Environmental effects abroad of major agency actions.

    Science.gov (United States)

    2010-04-01

    ... export of products (or emissions) that in the United States are prohibited or strictly regulated because... effects on natural and ecological resources of global importance designated under the Executive Order....

  3. Dual action mechanisms of KK-3, a newly synthesized leu-enkephalin derivative, in the production of spinal analgesic effects.

    Science.gov (United States)

    Takahashi, M; Senda, T; Kaneto, H

    1990-04-01

    The action mechanism for the production of spinal analgesia of KK-3, tyrosyl-N-methyl-gamma-aminobutylyl-phenylalaninol, was examined by the tail pinch and tail flick methods. Intrathecal KK-3, 2.5, 5 and 10 nmol/mouse, dose-dependently produced an analgesic effect in both methods. In the tail pinch method, the analgesia was suppressed by 2 mg/kg but not by 1 mg/kg of naloxone; however, the analgesic effect was significantly antagonized by 1 and 2 mg/kg Mr2266, a kappa-antagonist. Meanwhile, both naloxone and Mr2266 failed to block the analgesic effect of KK-3 in the tail flick test. Intrathecal capsaicin, 0.3, 3 and 15 nmol/mouse, also produced a dose-dependent analgesic effect in the tail flick test, whereas no appreciable analgesia could be found in the tail pinch test. Neither naloxone nor Mr2266 blocked the analgesic effect of capsaicin. The results indicate that KK-3 may possess two separate pharmacological mechanisms for the production of analgesic effects on the spinal level: one is the depletion of substance P following its release from the spinal cord, and the other is the mediation through kappa-opioid receptors. PMID:2342228

  4. Nongenomic steroid action: Inhibiting effects on cell-to-cell communication between rat ventricular myocytes

    OpenAIRE

    Verrecchia, Franck; Sarrouilhe, Denis; Hervé, Jean-Claude

    2001-01-01

    Numerous steroids are now believed to possess rapid membrane effects independent of the classical gene activation pathways and are potent modulators of membrane proteins, including voltage-and ligand-operated channels. The effects of steroids on the functional state of the intercellular channels clustered in gap junctions were compared by estimation of either the permeability for a fluorescent dye or the electrical conductance in cardiac myocytes of newborn rat. At 25 μM, the esters of 17β-es...

  5. Effect of Prenatal Exposure to Lead on Estrogen Action in the Prepubertal Rat Uterus

    OpenAIRE

    Tchernitchin, Andrei N.; Leonardo Gaete; Rodrigo Bustamante; Aracelly Báez

    2012-01-01

    Lead is a widely spread environmental pollutant known to affect both male and female reproductive systems in humans and experimental animals and causes infertility and other adverse effects. The present paper investigated the effects of prenatal exposure to lead on different parameters of estrogen stimulation in the uterus of the prepubertal rat. In prenatally and perinatally exposed rats, estrogen-induced endometrial eosinophilia, endometrial stroma edema, and eosinophil migration towards th...

  6. Carcinogenic effects of the combined action of /sup 241/Am and. gamma. -radiation

    Energy Technology Data Exchange (ETDEWEB)

    Filippova, L.G.; Buldakov, L.A.; Nifatov, A.P. (Institut Biofiziki, Moscow (USSR))

    In experiments on Wistar rats a study was made of the carcinogenic effects of the combined exposure to /sup 241/Am administered intrapertioneally (6.7 to 229.4 kBq/kg body weight) and external ..gamma..-radiation (/sup 137/Cs, 175 cGy). The occurrence of osteosarcoma, leucosis, skin and mammary tumors increased in the exposed animals. The combined irradiation produced an additive carcinogenic effect.

  7. The protective effect and action mechanism of Vaccinium myrtillus L. on gastric ulcer in mice.

    Science.gov (United States)

    Ogawa, Kenjirou; Oyagi, Atsushi; Tanaka, Junji; Kobayashi, Saori; Hara, Hideaki

    2011-08-01

    Vaccinium myrtillus L. anthocyanoside (VMA) is used as a folk medicine to treat diseases related to gastric ulcers in northern Europe. However, the effects of VMA and its detailed mechanism on gastric ulcer have not been investigated sufficiently. Therefore, the aim of the present study was to investigate the protective effects of VMA on gastric mucosal damage in a murine gastric ulcer model. First the effects of VMA on ethanol-induced gastric ulcers in mice were investigated. Then, the levels of lipid peroxide in murine stomach homogenates were measured to investigate the antioxidative effects of VMA. In addition, the free radical scavenging activity of VMA and its main anthocyanidins were evaluated by electron spin resonance measurement. Oral administration of VMA (10, 30 and 100 mg/kg) significantly protected gastric mucosa against HCl/ethanol-induced gastric ulcers. Furthermore, VMA inhibited lipid peroxide levels in a concentration-dependent manner and showed high scavenging activity against the superoxide anion radical (·O(2) (-) ) and the hydroxyl radical (·OH). Anthocyanidins also showed scavenging activity against the ·O(2) (-) , while only delphinidin showed high scavenging activity against the ·OH. These findings indicate that the protective effects of VMA on HCl/ethanol-induced gastric mucosal injury may be partially due to the antiperoxidative effects of anthocyanidins.

  8. Learning about goals: development of action perception and action control

    OpenAIRE

    Verschoor, Stephan Alexander

    2014-01-01

    By using innovative paradigms, the present thesis provides convincing evidence that action-effect learning, and sensorimotor processes in general play a crucial role in the development of action- perception and production in infancy. This finding was further generalized to sequential action. Furthermore the thesis suggests that means-selection-, ends-selection information, and action-effect knowledge together feed into a unitary concept of goal. Both these findings have the potential to gener...

  9. Facilitation effect of observed motor deviants in a cooperative motor task: Evidence for direct perception of social intention in action.

    Science.gov (United States)

    Quesque, François; Delevoye-Turrell, Yvonne; Coello, Yann

    2016-08-01

    Spatiotemporal parameters of voluntary motor action may help optimize human social interactions. Yet it is unknown whether individuals performing a cooperative task spontaneously perceive subtly informative social cues emerging through voluntary actions. In the present study, an auditory cue was provided through headphones to an actor and a partner who faced each other. Depending on the pitch of the auditory cue, either the actor or the partner were required to grasp and move a wooden dowel under time constraints from a central to a lateral position. Before this main action, the actor performed a preparatory action under no time constraint, consisting in placing the wooden dowel on the central location when receiving either a neutral ("prêt"-ready) or an informative auditory cue relative to who will be asked to perform the main action (the actor: "moi"-me, or the partner: "lui"-him). Although the task focused on the main action, analysis of motor performances revealed that actors performed the preparatory action with longer reaction times and higher trajectories when informed that the partner would be performing the main action. In this same condition, partners executed the main actions with shorter reaction times and lower velocities, despite having received no previous informative cues. These results demonstrate that the mere observation of socially driven motor actions spontaneously influences the low-level kinematics of voluntary motor actions performed by the observer during a cooperative motor task. These findings indicate that social intention can be anticipated from the mere observation of action patterns. PMID:26288247

  10. Evaluation of neural reflex activation as a mode of action for the acute respiratory effects of ozone.

    Science.gov (United States)

    Prueitt, Robyn L; Goodman, Julie E

    2016-09-01

    Exposure to elevated levels of ozone has been associated with a variety of respiratory-related health endpoints in both epidemiology and controlled human exposure studies, including lung function decrements and airway inflammation. A mode of action (MoA) for these effects has not been established, but it has been proposed that they may occur through ozone-induced activation of neural reflexes. We critically reviewed experimental studies of ozone exposure and neural reflex activation and applied the International Programme on Chemical Safety (IPCS) mode-of-action/human relevance framework to evaluate the biological plausibility and human relevance of this proposed MoA. Based on the currently available experimental data, we found that the proposed MoA of neural reflex activation is biologically plausible for the endpoint of ozone-induced lung function decrements at high ozone exposures, but further studies are needed to fill important data gaps regarding the relevance of this MoA at lower exposures. A role for the proposed MoA in ozone-induced airway inflammation is less plausible, as the evidence is conflicting and is also of unclear relevance given the lack of studies conducted at lower exposures. The evidence suggests a different MoA for ozone-induced inflammation that may still be linked to the key events in the proposed MoA, such that neural reflex activation may have some degree of involvement in modulating ozone-induced neutrophil influx, even if it is not a direct role. PMID:27569521

  11. Effects of imidapril on heterogeneity of action potential and calcium current of ventriclar myocytes in infarcted rabbits

    Institute of Scientific and Technical Information of China (English)

    YangLI; QiaoXUE; JieMA; Cun-taiZHANG; PingQIU; LinWANG; WeiGAO; ReiCHENG; Zai-yinLU; Shi-wenWANG

    2004-01-01

    AIM: To investigate the effects of chronic treatment with imidapril on the electrophysiologic heterogeneous change of the noninfarcted myocardium of rabbits after myocardial infarction and the mechanism of its antiarrhythmic efficacy. METHODS: Rabbits with left coronary artery ligation were prepared and allowed to recover for 8 weeks. Myocytes were isolated from subendocardial, midmyocardial, and subepicardial regions of the noninfarcted left ventricular wall. Action potentials and calcium current were recorded using whole-cell patch clamp technique. RESULTS: The action potential duration of repolarization 90 % (APD90) was more prolonged in midmyocardium rather than in subepicardium and subendocardium with healed myocardial infarction. The transmural dispersion of repolarization (TDR) was increased in the three ventricular regions. The amplitude of/Ca-L was enhanced but its density was decreased in noninfarcted ventricular myocytes due to increased cell membrane capacitance. The increased differences of calcium currents among subepicardium, midmyocardium, and subendocardium were also discovered. Normalization of heterogeneous changes in repolarization after treatment with imidapril was observed and decrease of TDR in noninfarcted area was measured. Early after depolarization (EAD) events of noninfarcted midmyocardium were markedly decreased by imidapril. CONCLUSION: Imidapril reduced the electrophysiologic heterogeneities in noninfarcted area in rabbits after myocardial infarction. This ability of imidapril may contribute to its antiarrhythmic efficacy.

  12. Effects of imidapril on heterogeneity of action potential and calcium current of ventriclar myocytes in infarcted rabbits

    Institute of Scientific and Technical Information of China (English)

    Yang LI; Shi-wen WANG; Qiao XUE; Jie MA; Cun-tai ZHANG; Ping QIU; Lin WANG; Wei GAO; Rei CHENG; Zai-ying LU

    2004-01-01

    AIM: To investigate the effects of chronic treatment with imidapril on the electrophysiologic heterogeneous change of the noninfarcted myocardium of rabbits after myocardial infarction and the mechanism of its antiarrhythmic efficacy. METHODS: Rabbits with left coronary artery ligation were prepared and allowed to recover for 8 weeks.Myocytes were isolated from subendocardial, midmyocardial, and subepicardial regions of the noninfarcted left ventricular wall. Action potentials and calcium current were recorded using whole-cell patch clamp technique.RESULTS: The action potential duration of repolarization 90 % (APD90)was more prolonged in midmyocardium rather than in subepicardium and subendocardium with healed myocardial infarction. The transmural dispersion of repolarization (TDR) was increased in the three ventricular regions. The amplitude of ICa-L was enhanced but its density was decreased in noninfarcted ventricular myocytes due to increased cell membrane capacitance. The increased differences of calcium currents among subepicardium, midmyocardium, and subendocardium were also discovered. Normalization of heterogeneous changes in repolarization after treatment with imidapril was observed and decrease of TDR in noninfarcted area was measvred. Early after depolarization (EAD) events of noninfarcted midmyocardium were markedly decreased by imidapril. CONCLUSION: Imidapril reduced the electrophysiologic heterogeneities in noninfarcted area in rabbits after myocardial infarction. This ability of imidapril may contribute to its antiarrhythmic efficacy.

  13. Effects of changes in frequency on guinea pig ventricular action potential duration and on QT interval under different experimental conditions.

    Science.gov (United States)

    von Savigny, L; Hohnloser, S; Antoni, H

    1981-01-01

    Isolated perfused guinea pig hearts (Langendorff preparation) were arrested by carbachol (0.1-0.2 mg/l) and electrically stimulated in the region of the av-conducting system. The QT interval was determined by means of extracellular electrodes at different driving frequencies. Separate experiments were performed on papillary muscles from the right ventricle to measure the duration of the transmembrane action potential under comparable conditions. At 35 degrees C (Ke+ 5.4 mmol/l) increasing the frequency of stimulation (range 12-120/min) caused the action potential duration (APD) to decrease to a greater extent than the QT interval. Stepwise rising of the external K+ concentration up to 16.2 mmol/l produced a nearly parallel shift to the APD-frequency relation to lower values. Again, the QT interval was less affected by increasing the external K+ concentration than the APD. Stepwise reduction of the temperature down to 20 degrees C prolonged the APD as well as the QT interval, the effects being more pronounced at lower than at higher stimulation frequencies. Under all examined experimental conditions, the APD proved to be markedly shorter than the QT interval even when the latter is diminished by the duration of QRS. The results suggest that no close relation exists between the APD and the QT interval. The observed divergencies may be due to functional differences among various parts of the ventricles.

  14. Antimicrobial effects of copper(II) bis(thiosemicarbazonato) complexes provide new insight into their biochemical mode of action.

    Science.gov (United States)

    Djoko, Karrera Y; Paterson, Brett M; Donnelly, Paul S; McEwan, Alastair G

    2014-04-01

    The copper(II) complexes of bis-thiosemicarbazones (Cu(btsc)) such as Cu(atsm) and Cu(gtsm) are neutral, lipophilic compounds that show promise as therapeutics for the treatment of certain neurological diseases and cancers. Although the effects of these compounds have been described at the cellular level, there is almost no information about their biochemical mode of action. In this work, we showed that Cu(atsm) and Cu(gtsm) displayed antimicrobial activities against the human obligate pathogen Neisseria gonorrhoeae that were more than 100 times more potent than Cu(NO3)2 salt alone. Treatment with Cu(btsc) also produced phenotypes that were consistent with copper poisoning, but the levels of intracellular copper were undetectable by ICP MS. We observed that Cu(btsc) interacted with proteins in the cell membrane. Systematic measurements of O2 uptake further demonstrated that treatment with both Cu(atsm) and Cu(gtsm) led to dose-dependent inhibition of respiratory electron transfer processes via succinate and NADH dehydrogenases. These dehydrogenases were not inhibited by a non-btsc source of Cu(II). The results led us to conclude that the biochemical mechanism of Cu(btsc) action is likely more complex than the present, simplistic model of copper release into the cytoplasm. PMID:24435165

  15. Simon in action: the effect of spatial congruency on grasping trajectories.

    Science.gov (United States)

    Freud, Erez; Aisenberg, Daniela; Salzer, Yael; Henik, Avishai; Ganel, Tzvi

    2015-01-01

    The Simon effect, one of the well-known stimulus-response compatibility effects, is usually explained as an expression of a conflict that occurs at the response selection stage. Here, we extended previous findings to provide evidence for post-response selection expression of the Simon effect. Following a presentation of a visual stimulus, participants grasped one of two objects that differed slightly in size. The results showed that visual stimulus congruency modulated grasping trajectories. Particularly, movements were more lateralized in congruent trials. This lateralization decreased as reaction time (RT) increased and therefore this effect could not be fully dissociated from the response selection stage. However, size sensitivity, as measured by the time taken to reach the maximum grip aperture between the fingers, was decreased for incongruent trials, unrelated to RT. This finding provides novel evidence for an independent expression of the Simon effect in post-response selection stages. Overall, our findings extend previous studies and demonstrate that the spatial conflict evoked by the Simon task encompasses several components and independently affects response selection stages as well as other components of motor execution.

  16. Participation of citral in the bronchodilatory effect of ginger oil and possible mechanism of action.

    Science.gov (United States)

    Mangprayool, Thitiya; Kupittayanant, Sajeera; Chudapongse, Nuannoi

    2013-09-01

    The extract of ginger, the rhizomes of Zingiber officinale Roscoe (Zingiberaceae), has been reported to possess anti-hyperactivity and anti-inflammation on airway. The present study described brochodilatory activity of ginger oil and identified its active compound. Ginger oil was extracted by hydro-distillation. The compositions of ginger oil were analyzed by gas chromatography and mass spectrometer. Citral, eucalyptol and camphene were found to be the major components. Ginger oil and citral, but not camphene, suppressed rat tracheal contraction induced by carbachol (CCh). Consistent with previous report, eucalyptol showed a relaxing effect on rat airway. Since the content of eucalyptol in ginger oil was relatively low, the contribution of eucalyptol to the bronchodilatory effect of ginger oil was small. To elucidate the mechanisms responsible for the myorelaxing effect, propranolol (a β-adrenergic receptor antagonist), indomethacin (a COX inhibitor) and L-NAME (a NOS inhibitor) were used to block the inhibitory effects of ginger oil and citral. It was found that propranolol, but not indomethacin and L-NAME, reversed bronchodilatory effects of both ginger oil and citral, suggesting that a possible mechanism involved β-adrenergic receptor. This study provides the pharmacological basis supporting the therapeutic potential of Z. officinale rhizomes as a bronchodilator. PMID:23685048

  17. Stereoscopically Observing Manipulative Actions.

    Science.gov (United States)

    Ferri, S; Pauwels, K; Rizzolatti, G; Orban, G A

    2016-08-01

    The purpose of this study was to investigate the contribution of stereopsis to the processing of observed manipulative actions. To this end, we first combined the factors "stimulus type" (action, static control, and dynamic control), "stereopsis" (present, absent) and "viewpoint" (frontal, lateral) into a single design. Four sites in premotor, retro-insular (2) and parietal cortex operated specifically when actions were viewed stereoscopically and frontally. A second experiment clarified that the stereo-action-specific regions were driven by actions moving out of the frontoparallel plane, an effect amplified by frontal viewing in premotor cortex. Analysis of single voxels and their discriminatory power showed that the representation of action in the stereo-action-specific areas was more accurate when stereopsis was active. Further analyses showed that the 4 stereo-action-specific sites form a closed network converging onto the premotor node, which connects to parietal and occipitotemporal regions outside the network. Several of the specific sites are known to process vestibular signals, suggesting that the network combines observed actions in peripersonal space with gravitational signals. These findings have wider implications for the function of premotor cortex and the role of stereopsis in human behavior. PMID:27252350

  18. Brane actions and string dualities

    NARCIS (Netherlands)

    Eyras, E; Lozano, Y; Ceresole, A; Kounnas, C; Lust, D; Theisen, S

    1999-01-01

    An effective action for the M9-brane is proposed. We study its relation with other branes via dualities. Among these, we find actions for branes which are not suggested by the central charges of the Type II superalgebras.

  19. Mechanism of Action of Rare Earths in High Effective Fe Powder Welding Rods

    Institute of Scientific and Technical Information of China (English)

    Han Yongquan; Li Jianguo; Yao Qinghu; Liu Yan; Huang Lihong

    2007-01-01

    The optimum coating composition of alkali Fe powder welding rods was designed by orthogonal experiment with mix rates. A new kind of effective RE-Fe powder welding rod was prepared which could be used at the condition of direct and indirect current. The arc characteristics and stabilities of effective Fe powder welding rods containing RE were analyzed by HANNOVER analyzer. The efficiency of Fe powder welding rods was tested by weighting method. It wag found that the stability of Fe powder welding rods Wag improved when it was added with rare earths. The results of impact experiment at low temperatures and SEM analysis on impact break showed that the grain was refined, the welding joint was cleaned, and the mechanical properties of joint was enhanced with proper RE content. It was provided with good processing property for this effective RE-Fe powder welding rod, and its efficiency could arrive at 180%.

  20. Effects of Nicotinamide on Mouse Skin Tumor Development and lts Mode of Action

    Institute of Scientific and Technical Information of China (English)

    KRISHNA P. GUPTA

    1999-01-01

    Nicotinamide (NA), a naturally occuring vitamin and a protease inhibitor, has been shown to be effective in treating some skin ailments. It inhibits cell proliferation and induces cell differentiation. This report shows the effects of NA on mouse skin tumor development and on the critical events involved in this process. NA reduced tumor growth, inhibited the 12-O-tetradecanoylphorbol- 13-acetate (TPA) induced ornithine decarboxylase activity, but induced the transglutaminase activity which was inhibited by TPA under different experimental conditions.The effects of NA on ornithine decarboxylase (ODC) and transglutaminase (TG) indicated that nicotinamide (NA) probably programmmed the cells for their death in the natural course of time, I.e. Programed cell death. This observation indicates that NA might be a better agent for the detailed study and for the better use in prevention of cancer alone or in combination with other drugs.

  1. Magnetoplastic effect: dislocation structure relaxation under the action of magnetic field in non-magnetic crystals

    International Nuclear Information System (INIS)

    A new physical phenomenon - magnetoplastic effect lying in shifting of dislocations under the influence of permanent magnetic field at the absence of mechanical load is detected and studied for some non-magnetic monocrystals (NaCl, LiF, CsI, Zn and Al). Experiments are carried out in B=0.1-2 T magnetic fields within T= 4.2-293 K range. Main properties of the observed effect enabling to introduce a hypothesis about its nature, are determined. 14 refs., 9 figs

  2. Draft effect on wave action with a semi-infinite elastic plate

    Institute of Scientific and Technical Information of China (English)

    TENG Bin; GOU Ying; CHENG Liang; LIU Shuxue

    2006-01-01

    A method for analyzing reflection and transmission of ocean waves from a semi-infinite elastic plate with a draft is developed. The relation of energy conservation for plates with three different edge conditions (free, simply supported and built-in) is also derived. It is found that the present method satisfies the energy relation very well. The effects of draft on wave reflection and transmission coefficients as well as on the vertical vibration of the plates are examined through numerical tests. It is demonstrated that the zero draft assumption works well for low wave frequencies, but the effect of plate draft becomes significant for high wave frequencies.

  3. Effects of Triclocarban on Intact Immature Male Rat: Augmentation of Androgen Action

    OpenAIRE

    Duleba, Antoni J.; Ahmed, Mohamed I.; Sun, Meng; Gao, Allen C.; Villanueva, Jesus; Conley, Alan J.; Turgeon, Judith L.; Benirschke, Kurt; Gee, Nancy A.; Chen, Jiangang; Green, Peter G.; Lasley, Bill L

    2011-01-01

    Triclocarban (TCC; 3,4,4′-trichlorocarbanilide) is an antimicrobial agent used widely in various personal hygiene products including soaps. Recently, TCC has been shown to enhance testosterone-induced effects in vitro and to enlarge accessory sex organs in castrated male rats. This study was designed to evaluate the effects of TCC on intact age-matched male rats and on human prostate LNCaP and C4–2B cells. Seven-week-old male Sprague-Dawley rats received either a normal diet or a diet supplem...

  4. "Just out of reach: On the reliability of the action-sentence compatibility effect": Correction to Papesh (2015).

    Science.gov (United States)

    2016-09-01

    Reports an error in "Just out of reach: On the reliability of the action-sentence compatibility effect" by Megan H. Papesh (, 2015[Dec], Vol 144[6], e116-e141). In the article, the Procedure did not directly state that response options were not visible on the computer screen during Experiments 7 and 8. The first sentence of the Procedure for Experiment 7 should read, "Participants completed a modified button-press version of the experiment described in Experiment 4; unlike Experiment 4, Experiment 7 included no visible on-screen elements apart from the to-be-judged sentences, which came from Glenberg and Kaschak (2002)." (The following abstract of the original article appeared in record .) The action-sentence compatibility effect (ACE; Glenberg & Kaschak, 2002), a hallmark finding in Embodied Cognition, implicates the motor system in language comprehension. In the ACE, people process sentences implying movement toward or away from themselves, responding with actions toward or away from their bodies. These processes interact, implying a linkage between linguistic and motor systems. From a theoretical perspective, the ACE has been extremely influential, being widely cited evidence in favor of embodied cognition. The present study began as an attempt to extend the ACE in a new direction, but eventually became a series of attempts to simply replicate the effect. Across 8 experiments, I tested whether the ACE extends to a novel mouse-tracking method and/or is susceptible to higher-order cognitive influences. In 3 experiments, attempts were made to "disembody" the ACE by presenting participants' names on the computer screen (as in Markman & Brendl, 2005). In each experiment, the ACE could not be disembodied, because the ACE did not occur. In further experiments, the ACE was not observed in reading times, regardless of response mode (mouse movements vs. button-presses) or stimuli, including those from the original research. Similarly, no ACE was observed in physical

  5. Inhibitory control training for appetitive behaviour change: A meta-analytic investigation of mechanisms of action and moderators of effectiveness.

    Science.gov (United States)

    Jones, Andrew; Di Lemma, Lisa C G; Robinson, Eric; Christiansen, Paul; Nolan, Sarah; Tudur-Smith, Catrin; Field, Matt

    2016-02-01

    Inhibitory control training (ICT) is a novel intervention in which participants learn to associate appetitive cues with inhibition of behaviour. We present a meta-analytic investigation of laboratory studies of ICT for appetitive behaviour change in which we investigate candidate mechanisms of action, individual differences that may moderate its effectiveness, and compare it to other psychological interventions. We conducted random-effects generic inverse variance meta-analysis on data from 14 articles (18 effect sizes in total). Participants who received ICT chose or consumed significantly less food or alcohol compared to control groups (SMD = 0.36, 95% CIs [0.24, 0.47]; Z = 6.18, p Effect sizes were larger for motor (Go/No-Go and Stop Signal) compared to oculomotor (Antisaccade) ICT. The effects of ICT on behaviour were comparable to those produced by other psychological interventions, and effects of ICT on food intake were greater in participants who were attempting to restrict their food intake. The magnitude of the effect of ICT on behaviour was predicted by the proportion of successful inhibitions but was unrelated to the absolute number of trials in which appetitive cues were paired with the requirement to inhibit, or the contingency between appetitive cues and the requirement to inhibit. The effect of ICT on cue devaluation (primarily assessed with implicit association tests) was not statistically significant. Our analysis confirms the efficacy of ICT for short-term behaviour change in the laboratory, and we have demonstrated that its effectiveness may depend on pairings between appetitive cues and successful inhibition. We highlight the need for further research to translate these findings outside of the laboratory. PMID:26592707

  6. Using the Dynamic Model of Educational Effectiveness to Design Strategies and Actions to Face Bullying

    Science.gov (United States)

    Kyriakides, Leonidas; Creemers, Bert P. M.; Muijs, Daniel; Rekers-Mombarg, Lyset; Papastylianou, Dona; Van Petegem, Peter; Pearson, Diana

    2014-01-01

    This project investigates the impact of the dynamic approach to school improvement (DASI) aiming to help schools face and reduce bullying through integrating research on bullying with educational effectiveness research (EER). A network of approximately 15 schools in each participating country (i.e., Belgium, Cyprus, England, Greece, and The…

  7. Using the dynamic model of educational effectiveness to design strategies and actions to face bullying

    NARCIS (Netherlands)

    Kyriakides, Leonidas; Creemers, Bert P.M.; Muijs, Daniel; Rekers-Mombarg, Lyset; Papastylianou, Donna; Van Petegem, Peter; Pearson, Diana

    2014-01-01

    This project investigates the impact of the dynamic approach to school improvement (DASI) aiming to help schools face and reduce bullying through integrating research on bullying with educational effectiveness research (EER). A network of approximately 15 schools in each participating country (i.e.,

  8. Chiral effects in adrenocorticolytic action of o,p'-DDD (mitotane) in human adrenal cells.

    Science.gov (United States)

    Asp, V; Cantillana, T; Bergman, A; Brandt, I

    2010-03-01

    Adrenocortical carcinoma (ACC) is a rare malignant disease with poor prognosis. The main pharmacological choice, o,p'-DDD (mitotane), produces severe adverse effects. Since o,p'-DDD is a chiral molecule and stereoisomers frequently possess different pharmacokinetic and/or pharmacodynamic properties, we isolated the two o,p'-DDD enantiomers, (R)-(+)-o,p'-DDD and (S)-(-)-o,p'-DDD, and determined their absolute structures. The effects of each enantiomer on cell viability and on cortisol and dehydroepiandrosterone (DHEA) secretion in the human adrenocortical cell line H295R were assessed. We also assayed the o,p'-DDD racemate and the m,p'- and p,p'-isomers. The results show small but statistically significant differences in activity of the o,p'-DDD enantiomers for all parameters tested. The three DDD isomers were equally potent in decreasing cell viability, but p,p'-DDD affected hormone secretion slightly less than the o,p'- and m,p'-isomers. The small chiral differences in direct effects on target cells alone do not warrant single enantiomer administration, but might reach importance in conjunction with possible stereochemical effects on pharmacokinetic processes in vivo.

  9. The Effect of 'Excessive' Tax Planning and Tax Setting on Welfare: Action Needed?

    NARCIS (Netherlands)

    H. Vrijburg (Hendrik)

    2014-01-01

    textabstract__Abstract__ This article presents a literature review on the welfare effects of excessive company taxation practices. The article intends to structure the debate by sketching a conceptual framework of thought for the topic under consideration and places the existing literature within t

  10. Metabolic action of neuropeptide Y in relation to its effect on feeding.

    Science.gov (United States)

    Ruffin, M P; Even, P C; El-Ghissassi, M; Nicolaidis, S

    1997-12-01

    Because energy homeostasis depends on a continuous balance between food intake, energy expenditure, and energy storage, it was expected that neuropeptide Y (NPY) could act not only on food intake but also on metabolic parameters. Using an original calorimetric device that allows the computation of the background metabolism (energy expenditure free from the cost of locomotor activity), we assessed the effect of a microinjection of NPY upon the quantitative (background metabolism, thermic effect of food) and qualitative (respiratory quotient) components of energy metabolism. NPY was injected into the juxtafornical hypothalamus at a dose that promotes feeding behavior (1 microg/0.5 microL) and enhances locomotor activity. Although total metabolism was increased proportionally to locomotion, no effect of NPY on background metabolism was observed when no food was available. Only following a calibrated meal given 30 min after the microinjection did NPY induce a delayed decrease in respiratory quotient whereas the postprandial background metabolism remained unaffected. In conclusion, only the new-generation calorimeters can show that the NPY-induced rise in overall metabolic rate is entirely accounted for by the unavoidable enhancement in locomotor activity and that the only metabolic effect of NPY is the delayed postprandial respiratory quotient decrease, suggesting a postabsorptive orientation toward more lipid utilization. PMID:9383111

  11. Pharmaceutical residues in aquatic systems: mode of action and effects on mussel physiology

    OpenAIRE

    Buratti, Sara

    2011-01-01

    Pharmaceutical residues contaminate aquatic ecosystems as a result of their widespread human and veterinary usage. Since continuously released and not efficiently removed, certain pharmaceuticals exhibit pseudo-persistence thus generating concerns for the health of aquatic wildlife. This work aimed at assessing on mussels Mytilus galloprovincialis, under laboratory conditions, the effects of three pharmaceuticals, carbamazepine (antiepileptic), propranolol (β-blocker) and oxytetracycline (...

  12. Acceptance and Values-Based Action in Chronic Pain: A Study of Treatment Effectiveness and Process

    Science.gov (United States)

    Vowles, Kevin E.; McCracken, Lance M.

    2008-01-01

    Developing approaches within cognitive behavioral therapy are increasingly process-oriented and based on a functional and contextual framework that differs from the focus of earlier work. The present study investigated the effectiveness of acceptance and commitment therapy (S. C. Hayes, K. Strosahl, & K. G. Wilson, 1999) in the treatment of…

  13. Action Research on Effects of a Pidgin English (Open to Suggestion).

    Science.gov (United States)

    Aina, Joseph O.

    1991-01-01

    Investigates the effects of Pidgin English used for communication outside the classroom on Nigerian students' reading and writing. Concludes that knowledge of Pidgin English favorably affected Standard English reading comprehension but did not help writing. Notes that Pidgin-speaking students have solid linguistic competencies on which to build.…

  14. Effects of Isoflurane on the Actions of Neuromuscular Blockers on the Muscle Nicotine Acetylcholine Receptors

    Institute of Scientific and Technical Information of China (English)

    李传翔; 姚尚龙; 聂辉; 吕斌

    2004-01-01

    In this study, we tested the hypothesis that volatile anesthetic enhancement of muscle relaxation is the result of combined drug effects on the nicotinic acetylcholine receptors. The poly A m RNA from muscle by isolation were microinjected into Xenopus oocytes for receptor expression.Concentration-effect curves for the inhibition of Ach-induced currents were established for vecuronium, rocuranium, and isoflurane. Subsequently, inhibitory effects of NDMRs were studied in the presence of the isoflurane at a concentration equivalent to half the concentration producing a 50 %inhibition alone. All tested drugs produced rapid and readily reversible concentration-dependent inhibition. The 50 % inhibitory concentration values were 889 μmol/L (95 % CI: 711-1214μmol),33.4 μmol (95 % CI: 27.1-41.7 nmol) and 9.2 nmol (95 % CI: 7.9-12.3 nmol) for isoflurane,rocuranium and vecuronium, respectively. Coapplication of isoflurane significantly enhanced the inhibitory effects of rocuranium and vecuronium, and it was especially so at low concentration of NMDRs. Isoflurane increases the potency of NDMRs, possibly by enhancing antagonist affinity at the receptor site.

  15. Effectiveness of elite female basketball players’ technical-tactic actions and ways for their improvement at stage of maximal realization of individual potentials

    Directory of Open Access Journals (Sweden)

    Sushko R.A.

    2015-08-01

    Full Text Available Purpose: study effectiveness of elite female basketball players’ technical-tactic actions and determine the ways for their improvement at stage of maximal realization of individual potentials. Material: the authors analyzed competition functioning’s indicators of female basketball players of national combined team of Ukraine and their age characteristics. Results: effectiveness of technical-tactic actions in structure of national female basketball players’ combined team of Ukraine competition functioning at European championship. The authors present: indicators of team composition; roles in team; won and lost games; quantity of scored and skipped points; technical-tactic actions; age of sportswomen. Age indicators of elite female basketball players at stage of maximal realization have been given. Conclusions: we have composed a list of the most important technical-tactic actions in competition functioning. We also outlined ways for their perfection at stage of maximal realization of individual potentials of elite female basketball players of different game roles.

  16. Differential Effects of Secretin-fragments imply a dual Mechanism of Action for Secretin

    DEFF Research Database (Denmark)

    Kofod, Hans; Thams, P; Holst, J J

    1991-01-01

    higher activity than that earlier shown for S22-27 and had the same effect on the dynamic pattern of insulin release as secretin, while the elongating sequence Leu-Gln-Arg (S19-21) had no effect on the insulin release. The nonapeptide Leu-Ser-Arg-Leu-Arg-Asp-Ser-Ala-Arg (S10-18) had no influence...... on the insulin release. Glucagon release seen after intact secretin could not be shown for any of the smaller fragments. Accumulation of cAMP in the islets as seen with secretin, could at 10 mmol/L D-glucose only be demonstrated with S22-27 or S19-27 but not with S10-18 or S1-6. Our results indicate that full...

  17. Public health in action: effective school health needs renewed international attention

    OpenAIRE

    Benzian, Habib; Monse, Bella; Belizario, Jr., Vicente; Schratz, Alexander; Sahin, Murat; Palenstein Helderman, Wim Van

    2012-01-01

    School health programmes as a platform to deliver high-impact health interventions are currently underrated by decision makers and do not get adequate attention from the international public health community. We describe the award-winning Fit for School Approach from the Philippines as an example of a large-scale, integrated, cost-effective and evidence-based programme that bridges the gap between sectors, and between evidence and practice. In view of the challenges to achieve the health and ...

  18. Participatory Action Research: Effect of Emphasising Graduate Attributes on Work-Placement Reflection

    OpenAIRE

    Dunne, Julie

    2015-01-01

    This project aimed to investigate what the effect of activities to promote awareness of graduate attributes development introduced during 2014/15 would be on the quality of reflection displayed in student pharmacy technicians’ workplacement blogs. The project was undertaken in response to a deficit in critical reflection shown in earlier years. The work-placement blogs from 2013/14 were used as a comparison for this study. The theoretical perspective included a constructivist ontological posi...

  19. Optimizing Effectiveness in Electronic Prescriptions for Pediatric Outpatients: A Call for Responsive Action

    OpenAIRE

    Parrish II, Richard H.; Sandra Benavides; Joseph T. Malak; Amy L Potts; Micheal Guirguis; Tracy Hagemann

    2014-01-01

    A pediatric compounded non-sterile products repository (pCNP) to optimize the effectiveness and safety of “off-label” use of compounded pharmacotherapy through complete transmission of electronic prescriptions across the continuum of care is described. The advent of electronic prescribing has the potential to refocus and resolve long-standing issues of prescription therapy for pediatric patients related to formulation, indication, dosing, and outcomes follow-up, among others. This white paper...

  20. Effects of Honey and Its Mechanisms of Action on the Development and Progression of Cancer

    Directory of Open Access Journals (Sweden)

    Omotayo O. Erejuwa

    2014-02-01

    Full Text Available Honey is a natural product known for its varied biological or pharmacological activities—ranging from anti-inflammatory, antioxidant, antibacterial, antihypertensive to hypoglycemic effects. This review article focuses on the role of honey in modulating the development and progression of tumors or cancers. It reviews available evidence (some of which is very recent with regards to the antimetastatic, antiproliferative and anticancer effects of honey in various forms of cancer. These effects of honey have been thoroughly investigated in certain cancers such as breast, liver and colorectal cancer cell lines. In contrast, limited but promising data are available for other forms of cancers including prostate, bladder, endometrial, kidney, skin, cervical, oral and bone cancer cells. The article also underscores the various possible mechanisms by which honey may inhibit growth and proliferation of tumors or cancers. These include regulation of cell cycle, activation of mitochondrial pathway, induction of mitochondrial outer membrane permeabilization, induction of apoptosis, modulation of oxidative stress, amelioration of inflammation, modulation of insulin signaling and inhibition of angiogenesis. Honey is highly cytotoxic against tumor or cancer cells while it is non-cytotoxic to normal cells. The data indicate that honey can inhibit carcinogenesis by modulating the molecular processes of initiation, promotion, and progression stages. Thus, it may serve as a potential and promising anticancer agent which warrants further experimental and clinical studies.

  1. A strategy for regulatory action when new adverse effects of a licensed product emerge.

    Science.gov (United States)

    Aronson, Jeffrey K; Price, Deirdre; Ferner, Robin E

    2009-01-01

    Regulatory agencies grant product licences (marketing authorizations) for medicinal products in the light of evidence that the balance between benefit and harm in the population is favourable. Here we consider a framework for allowing regulatory agencies to make rational decisions when reviewing product licences in the light of new information about harms that change that balance. The regulator can revoke the product licence, restrict the product's availability or change the 'label' in different ways. We examine the features of the adverse effect that may be relevant in making the decision: namely, individual differences in susceptibility; the possibility of monitoring; and the availability of protective strategies. The balance of benefit and harm, and the time-course and dose relation of the adverse effect play important roles in the decision-making process. We set out how these factors can help determine the logical response to new information on the balance between benefit and harm, and provide a series of relevant examples. We believe that when regulatory agencies have to decide how to amend the product licence of a drug when new serious adverse effects cause concern, they would find it useful to adopt a framework of this kind, using different strategies for different cases. Our proposed framework could also be useful in risk management planning during drug development.

  2. THE EFFECT OF HYPOXIA ON THE MAXIMUM MATABOLIC RATE AND SPECIFIC DYNAMIC ACTION IN ATLANTIC COD Gadus morhua

    DEFF Research Database (Denmark)

    Steffensen, John Fleng

    2010-01-01

    the fi sh. The fish were fed single rations of fillets of herring, equivalent to 5 % wet body mass. Hypoxia was controlled by an oxygen regulator injecting compressed nitrogen in the water via a solenoid valve. In addition the maximum metabolic rate of starved fish was measured in normoxia and 4 levels...... and fish kept at high densities. Feeding is followed by an increase in the metabolic rate. termed the specific dynamic action (SDA). SDA integrates all the energetic expenditures involved in feeding. It is generally agreed that the increased metabolic rate is caused by biochemical transformation of food...... of hypoxia compared. Maximum metabolic rate compared to standard metabolic rate is termed the Scope for Activity. The results showed that hypoxia at 6.3 kPa does influence the SDA. The effect on the SDA curve on cod fed 5 % of the wet body mass was that the peak metabolic rate was significantly depressed (44...

  3. Multi-Scale Action Effectiveness Research in the Lower Columbia River and Estuary, 2011 - FINAL ANNUAL REPORT

    Energy Technology Data Exchange (ETDEWEB)

    Sather, Nichole K.; Storch, Adam; Johnson, Gary E.; Teel, D. J.; Skalski, J. R.; Bryson, Amanda J.; Kaufmann, Ronald M.; Woodruff, Dana L.; Blaine, Jennifer; Kuligowski, D. R.; Kropp, Roy K.; Dawley, Earl M.

    2012-05-31

    The study reported here was conducted by researchers at Pacific Northwest National Laboratory (PNNL), the Oregon Department of Fish and Wildlife (ODFW), the University of Washington (UW), and the National Marine Fisheries Service (NMFS) for the U.S. Army Corps of Engineers, Portland District (USACE). This research project was initiated in 2007 by the Bonneville Power Administration to investigate critical uncertainties regarding juvenile salmon ecology in shallow tidal freshwater habitats of the lower Columbia River. However, as part of the Washington Memorandum of Agreement, the project was transferred to the USACE in 2010. In transferring from BPA to the USACE, the focus of the tidal freshwater research project shifted from fundamental ecology toward the effectiveness of restoration in the Lower Columbia River and estuary (LCRE). The research is conducted within the Action Agencies Columbia Estuary Ecosystem Restoration Program (CEERP). Data reported herein spans the time period May 2010 to September 2011.

  4. Consistency of the Hamiltonian formulation of the lowest-order effective action of the complete Horava theory

    International Nuclear Information System (INIS)

    We perform the Hamiltonian analysis for the lowest-order effective action, up to second order in derivatives, of the complete Horava theory. The model includes the invariant terms that depend on ∂ilnN proposed by Blas, Pujolas, and Sibiryakov. We show that the algebra of constraints closes. The Hamiltonian constraint is of second-class behavior and it can be regarded as an elliptic partial differential equation for N. The linearized version of this equation is a Poisson equation for N that can be solved consistently. The preservation in time of the Hamiltonian constraint yields an equation that can be consistently solved for a Lagrange multiplier of the theory. The model has six propagating degrees of freedom in the phase space, corresponding to three even physical modes. When compared with the λR model studied by us in a previous paper, it lacks two second-class constraints, which leads to the extra even mode.

  5. Seeing and Being Green? The Effect of Money Priming on Willingness to Perform Sustainable Actions, Social Connectedness, and Prosociality.

    Science.gov (United States)

    Capaldi, Colin A; Zelenski, John M

    2016-01-01

    This investigation attempted to conceptually replicate/extend research that suggests that reminders of money can inhibit prosociality, promote self-sufficiency, and influence political beliefs. Based on these results, we hypothesized that money primes would decrease willingness to engage in sustainable actions. We also predicted that people would distribute points less prosocially and feel less socially connected when money was primed. Individuals were recruited from an undergraduate participant pool and MTurk. Meta-analytic results across the two samples revealed that money priming did not have a significant impact on willingness to act sustainably, but it did cause participants to distribute points less prosocially and report lower social connectedness than individuals in the control condition. While effects were smaller than those reported in Vohs, Mead, and Goode (2006), this study still offers support for the detrimental impact of reminders of money on interpersonal relations. PMID:25950374

  6. Observations of the Joint Action of the Hanle and Zeeman Effects in the D2 Line of BaII

    CERN Document Server

    Ramelli, R; Bueno, J Trujillo; Belluzzi, L; Degl'Innocenti, E Landi

    2009-01-01

    We show a selection of high-sensitivity spectropolarimetric observations obtained over the last few years in the Ba II D2-line with the Zurich Imaging Polarimeter (ZIMPOL) attached to the Gregory Coude Telescope of IRSOL. The measurements were collected close to the solar limb, in several regions with varying degree of magnetic activity. The Stokes profiles we have observed show clear signatures of the joint action of the Hanle and Zeeman effects, in very good qualitative agreement with the theoretical expectations. Polarimetric measurements of this line show to be very well suited for magnetic field diagnostics of the lower solar chromosphere, from regions with field intensities as low as 1 gauss to strongly magnetized ones having kG field strengths.

  7. Ultra-rapid access to words in chronic aphasia: the effects of intensive language action therapy (ILAT).

    Science.gov (United States)

    MacGregor, Lucy J; Difrancesco, Stephanie; Pulvermüller, Friedemann; Shtyrov, Yury; Mohr, Bettina

    2015-03-01

    Effects of intensive language action therapy (ILAT) on automatic language processing were assessed using Magnetoencephalography (MEG). Auditory magnetic mismatch negativity (MMNm) responses to words and pseudowords were recorded in twelve patients with chronic aphasia before and immediately after two weeks of ILAT. Following therapy, Patients showed significant clinical improvements of auditory comprehension as measured by the Token Test and in word retrieval and naming as measured by the Boston Naming Test. Neuromagnetic responses dissociated between meaningful words and meaningless word-like stimuli ultra-rapidly, approximately 50 ms after acoustic information first allowed for stimulus identification. Over treatment, there was a significant increase in the left-lateralisation of this early word-elicited activation, observed in perilesional fronto-temporal regions. No comparable change was seen for pseudowords. The results may reflect successful, therapy-induced, language restitution in the left hemisphere. PMID:25403745

  8. Anti-amnestic and anti-aging effects of ginsenoside Rg1 and Rb1 and its mechanism of action

    Institute of Scientific and Technical Information of China (English)

    Yong CHENG; Li-hong SHEN; Jun-tian ZHANG

    2005-01-01

    In the present paper, we overview the discovery of new biological activities induced by ginsenoside Rg1 and Rb1 and discuss possible mechanisms of action. Both compounds could increase neural plasticity in efficacy and structure; espe cially Rg1, as one small molecular drug, can increase proliferation and differentia tion of neural progenitor cells in dentate gyms of hippocampus of normal adult mice and global ischemia model in gerbils. This finding has great value for treat ment of Alzheimer's disease and other neurodegenerative disorders which is characterized by neurons loss. Increase of expression of brain derived neurotrophic factor, Bcl-2 and antioxidant enzyme, enhanced new synapse formation, inhibition of apoptosis and calcium overload are also important neuron protective factors. Rg1 and Rb1 have common effects, but there are some differences in pharmacol ogy and mechanism. These differences may attribute to their different chemical structure. Rg1 is panaxtriol with two sugars, while Rb1 is panaxtriol with four sugars.

  9. Seeing and Being Green? The Effect of Money Priming on Willingness to Perform Sustainable Actions, Social Connectedness, and Prosociality.

    Science.gov (United States)

    Capaldi, Colin A; Zelenski, John M

    2016-01-01

    This investigation attempted to conceptually replicate/extend research that suggests that reminders of money can inhibit prosociality, promote self-sufficiency, and influence political beliefs. Based on these results, we hypothesized that money primes would decrease willingness to engage in sustainable actions. We also predicted that people would distribute points less prosocially and feel less socially connected when money was primed. Individuals were recruited from an undergraduate participant pool and MTurk. Meta-analytic results across the two samples revealed that money priming did not have a significant impact on willingness to act sustainably, but it did cause participants to distribute points less prosocially and report lower social connectedness than individuals in the control condition. While effects were smaller than those reported in Vohs, Mead, and Goode (2006), this study still offers support for the detrimental impact of reminders of money on interpersonal relations.

  10. Studies on inhibitory effect of Baicalein on MCF-7 Cells and its mechanism of action

    International Nuclear Information System (INIS)

    Acute toxicity to the normal cells from the conventional chemotherapeutic drugs has been one of the stumbling blocks for effective therapy. Further, increased acidity and hypoxia in solid tumour decreases the therapeutic effectiveness of radiotherapy and chemotherapy. The transcriptional response to cellular hypoxia is primarily mediated by the transcription factor hypoxia-inducible factor-1 (HIF-1). Thus, controlling HIF-1 could be an attractive target for cancer therapy. In view of the above considerations studies were undertaken to identify the phytoceutical which can be effective for cancer therapy. One of the phytoceutical being studied is Saicalein (BA), a compound extracted from the root of Scutellaria boicalensis, which is an active flavonoid extensively used in traditional Chinese medicine. In the present study the effects of BA on toxicity to the MCF-7 line was tested. MCF-7 cells when treated with BA exhibited concentration dependent toxicity. MCF-7 cells when treated with BA at the concentration of 50 μM, 50% cells lost viability. Further, it was shown that BA radio-sensitize the MCF-7 cells in vitro, as tested by LDH leakage assay. Radiation (4 Gy) alone did not show marked LDH leakage, however post radiation exposure treatment with BA (50 μM) of MCF-7 cells resulted in increased LDH leakage. In vitro wound healing assay was performed - which is the test for cell migration and cell proliferation. BA inhibited the wound closure by 97%. Overall the results demonstrate the anticancer potential of BA. In order to determine the effect of BA on transcription activation by HIF-1, a cell-based reporter assay for HIF-1 functional antagonist in MCF-7 cells was established. A luciferase reporter gene under the control of HRE from the erythropoietin gene (pTK-HRE3-luc) was employed to monitor HIF-1 activity. MCF-7 cells were transiently transfected with aforementioned plasmid followed by growing them in the presence of CoCl2, (hypoxia mimetic agent) and under

  11. Action spectra again?

    Science.gov (United States)

    Coohill, T P

    1991-11-01

    Action spectroscopy has a long history and is of central importance to photobiological studies. Action spectra were among the first assays to point to chlorophyll as the molecule most responsible for plant growth and to DNA as the genetic material. It is useful to construct action spectra early in the investigation of new areas of photobiological research in an attempt to determine the wavelength limits of the radiation region causing the studied response. But due to the severe absorption of ultraviolet (UV) radiation by biological samples, UV action spectra were first limited to small cells (bacteria and fungi). Advances in techniques (e.g. single cell culture) and analysis allowed accurate action spectra to be reported even for mammalian cells. But precise analytical action spectra are often difficult to obtain when large, pigmented, or groups of cells are investigated. Here some action spectra are limited in interpretation and merely supply a wavelength vs effect curve. When polychromatic sources are employed, the interpretation of action spectra is even more complex and formidable. But such polychromatic action spectra can be more directly related to ambient responses. Since precise action spectra usually require the completion of a relatively large number of careful experiments using somewhat sophisticated equipment over a range of at least six wavelengths, they are often not pursued. But they remain central to the elucidation of the effect being studied. The worldwide community has agreed that stratospheric ozone is depleting, with the possibility of a consequent rise in the amount of UV-B (290-320 nm) reaching the earth's surface. It is therefore essential that new action spectra be completed for UV-B effects on a large variety of responses of human, animal, and aquatic plant systems. Combining these action spectra with the known amounts of UV-B reaching the biosphere can give rise to solar UV effectiveness spectra that, in turn, can give rise to estimates

  12. [Review of the effects of mindfulness meditation on mental and physical health and its mechanisms of action].

    Science.gov (United States)

    Ngô, Thanh-Lan

    2013-01-01

    Interventions based on mindfulness have become increasingly popular. This article reviews the empirical literature on its effects on mental and physical health, discusses presumed mechanisms of action as well as its proposed neurobiological underpinning. Mindfulness is associated with increased well-being as well as reduced cognitive reactivity and behavioral avoidance. It seems to contribute to enhance immune functions, diminish inflammation, diminish the reactivity of the autonomic nervous system, increase telomerase activity, lead to higher levels of plasmatic melatonin and serotonin. It enhances the quality of life for patients suffering from chronic pain, fibromylagia and HIV infection. It facilitates adaptation to the diagnosis of cancer and diabetes. It seems to lead to symptomatic improvement in irritable bowel syndrome, chronic fatigue syndrome, hot flashes, insomnia, stress related hyperphagia. It diminishes craving in substance abuse. The proposed mechanism of action are enhanced metacognitive conscience, interoceptive exposure, experiential acceptance, self-management, attention control, memory, relaxation. Six mechanism of actions for which neurological underpinnings have been published are: attention regulation (anterior cingulate cortex), body awareness (insula, temporoparietal junction), emotion regulation (modulation of the amygdala by the lateral prefrontal cortex), cognitive re-evaluation (activation of the dorsal medial prefrontal cortex or diminished activity in prefrontal regions), exposure/extinction/reconsolidation (ventromedial prefrontal cortex, hippocampus, amygdala) and flexible self-concept (prefrontal median cortex, posterior cingulated cortex, insula, temporoparietal junction). The neurobiological effects of meditation are described. These are: (1) the deactivation of the default mode network that generates spontaneous thoughts, contributes to the maintenance of the autobiographical self and is associated with anxiety and depression

  13. Anti-Inflammatory Applications of Melittin, a Major Component of Bee Venom: Detailed Mechanism of Action and Adverse Effects.

    Science.gov (United States)

    Lee, Gihyun; Bae, Hyunsu

    2016-01-01

    Inflammation is a pervasive phenomenon triggered by the innate and adaptive immune systems to maintain homeostasis. The phenomenon normally leads to recovery from infection and healing, but when not properly phased, inflammation may cause immune disorders. Bee venom is a toxin that bees use for their protection from enemies. However, for centuries it has been used in the Orient as an anti-inflammatory medicine for the treatment of chronic inflammatory diseases. Bee venom and its major component, melittin, are potential means of reducing excessive immune responses and provide new alternatives for the control of inflammatory diseases. Recent experimental studies show that the biological functions of melittin could be applied for therapeutic use in vitro and in vivo. Reports verifying the therapeutic effects of melittin are accumulating in the literature, but the cellular mechanism(s) of the anti-inflammatory effects of melittin are not fully elucidated. In the present study, we review the current knowledge on the therapeutic effects of melittin and its detailed mechanisms of action against several inflammatory diseases including skin inflammation, neuroinflammation, atherosclerosis, arthritis and liver inflammation, its adverse effects as well as future prospects regarding the use of melittin. PMID:27187328

  14. Anti-Inflammatory Applications of Melittin, a Major Component of Bee Venom: Detailed Mechanism of Action and Adverse Effects

    Directory of Open Access Journals (Sweden)

    Gihyun Lee

    2016-05-01

    Full Text Available Inflammation is a pervasive phenomenon triggered by the innate and adaptive immune systems to maintain homeostasis. The phenomenon normally leads to recovery from infection and healing, but when not properly phased, inflammation may cause immune disorders. Bee venom is a toxin that bees use for their protection from enemies. However, for centuries it has been used in the Orient as an anti-inflammatory medicine for the treatment of chronic inflammatory diseases. Bee venom and its major component, melittin, are potential means of reducing excessive immune responses and provide new alternatives for the control of inflammatory diseases. Recent experimental studies show that the biological functions of melittin could be applied for therapeutic use in vitro and in vivo. Reports verifying the therapeutic effects of melittin are accumulating in the literature, but the cellular mechanism(s of the anti-inflammatory effects of melittin are not fully elucidated. In the present study, we review the current knowledge on the therapeutic effects of melittin and its detailed mechanisms of action against several inflammatory diseases including skin inflammation, neuroinflammation, atherosclerosis, arthritis and liver inflammation, its adverse effects as well as future prospects regarding the use of melittin.

  15. Enforcement actions: Significant actions resolved

    International Nuclear Information System (INIS)

    This compilation summarizes significant enforcement actions that have been resolved during one quarterly period (October--December 1990) and includes copies of letters, Notices, and Orders sent by the Nuclear Regulatory Commission to licensees with respect to these enforcement actions. It is anticipated that the information in this publication will be widely disseminated to managers and employees engaged in activities licensed by the NRC, so that actions can be taken to improve safety by avoiding future violations similar to those described in this publication

  16. Enforcement actions: Significant actions resolved

    International Nuclear Information System (INIS)

    This compilation summarizes significant enforcement actions that have been resolved during one quarterly period (January--March 1992) and includes copies of letters, Notices, and Orders sent by the Nuclear Regulatory Commission to licensees with respect to these enforcement actions. It is anticipated that the information in this publication will be widely disseminated to managers and employees engaged in activities licensed by the NRC, so that actions can be taken to improve safety by avoiding future violations similar to those described in this publication

  17. Enforcement actions: Significant actions resolved

    International Nuclear Information System (INIS)

    This compilation summarizes significant enforcement actions that have been resolved during one quarterly period (October--December 1992) and includes copies of letters, Notices, and Orders sent by the Nuclear Regulatory Commission to licensees with respect to these enforcement actions. It is anticipated that the information in this publication will be widely disseminated to managers and employees engaged in activities licensed by the NRC, so that actions can be taken to improve safety by avoiding future violations similar to those described in this publication

  18. Enforcement actions: Significant actions resolved

    International Nuclear Information System (INIS)

    This compilation summarizes significant enforcement actions that have been resolved during one quarterly period (April-June 1991) and includes copies of letters, Notices, and Orders sent by the Nuclear Regulatory Commission to licensees with respect to these enforcement actions. It is anticipated that the information in this publication will be widely disseminated to managers and employees engaged in activities licensed by the NRC, so that actions can be taken to improve safety by avoiding future violations similar to those described in this publication

  19. Enforcement actions: Significant actions resolved

    International Nuclear Information System (INIS)

    This compilation summarizes significant enforcement actions that have been resolved during one quarterly period (July--September 1989) and includes copies of letters, Notices, and Orders sent by the Nuclear Regulatory Commission to licensees with respect to these enforcement actions. It is anticipated that the information in this publication will be widely disseminated to managers and employees engaged in activities licensed by the NRC, so that actions can be taken to improve safety by avoiding future violations similar to those described in this publication

  20. Enforcement actions: Significant actions resolved

    International Nuclear Information System (INIS)

    This compilation summarizes significant enforcement actions that have been resolved during one quarterly period (April--June 1992) and includes copies of letters, Notices, and Orders sent by the Nuclear Regulatory Commission to licensees with respect to these enforcement actions. It is anticipated that the information in this publication will be widely disseminated to managers and employees engaged in activities licensed by the NRC, so that actions can be taken to improve safety by avoiding future violations similar to those described in this publication