WorldWideScience

Sample records for 10-specific small interference

  1. Small Aircraft RF Interference Path Loss

    Science.gov (United States)

    Nguyen, Truong X.; Koppen, Sandra V.; Ely, Jay J.; Szatkowski, George N.; Mielnik, John J.; Salud, Maria Theresa P.

    2007-01-01

    Interference to aircraft radio receivers is an increasing concern as more portable electronic devices are allowed onboard. Interference signals are attenuated as they propagate from inside the cabin to aircraft radio antennas mounted on the outside of the aircraft. The attenuation level is referred to as the interference path loss (IPL) value. Significant published IPL data exists for transport and regional category airplanes. This report fills a void by providing data for small business/corporate and general aviation aircraft. In this effort, IPL measurements are performed on ten small aircraft of different designs and manufacturers. Multiple radio systems are addressed. Along with the typical worst-case coupling values, statistical distributions are also reported that could lead to better interference risk assessment.

  2. Small Aircraft RF Interference Path Loss Measurements

    Science.gov (United States)

    Nguyen, Truong X.; Koppen, Sandra V.; Ely, Jay J.; Szatkowski, George N.; Mielnik, John J.; Salud, Maria Theresa P.

    2007-01-01

    Interference to aircraft radio receivers is an increasing concern as more portable electronic devices are allowed onboard. Interference signals are attenuated as they propagate from inside the cabin to aircraft radio antennas mounted on the outside of the aircraft. The attenuation level is referred to as the interference path loss (IPL) value. Significant published IPL data exists for transport and regional category airplanes. This report fills a void by providing data for small business/corporate and general aviation aircraft. In this effort, IPL measurements are performed on ten small aircraft of different designs and manufacturers. Multiple radio systems are addressed. Along with the typical worst-case coupling values, statistical distributions are also reported that could lead to more meaningful interference risk assessment.

  3. Small-cell network downlink interference suppression method

    Directory of Open Access Journals (Sweden)

    ZHANG Daoxu

    2015-02-01

    Full Text Available In order to control the level of interference among adjacent small-cells effectively,in this paper,we suppress the interference between adjacent small-cells through controlling the small-cell downlink transmission power.Meanwhile,we use a low complexity subcarrier allocation scheme,making small-cell downlink rate be improved as much as possible.In small cell downlink transmission power control,we use a generalized water-filling algorithm which gives the optimal solution of downlink transmission power.Simulation results show that subcarrier allocation scheme and power allocation algorithm can improve small-cell downlink transmission rate and control the level of interference between adjacent small-cell effectively.

  4. Interference-robust Air Interface for 5G Small Cells

    DEFF Research Database (Denmark)

    Tavares, Fernando Menezes Leitão

    . To meet these challenging network capacity expansion requirements, the design of the new 5G RAT standard will make use of three main strategies: more antennas, more spectrum and more cells. All these strategies will have important roles in the new system, but the deployment of a massive number of small...... cells, especially indoors, is expected to provide the largest improvement in network capacity. However, the benefits of this type of ultra-dense deployment do not come for free; strong inter-cell interference, an inherent problem of dense networks, has the potential to limit the expected gains. Due...... robustness is achieved by the clever design of the radio frame structure in such a way that interference suppression receivers can efficiently and effectively mitigate the effects of inter-cell interference. A detailed receiver model is derived (including also receiver imperfections, such as estimation...

  5. RNA interference and small interference RNA%RNA干涉和小干涉RNA

    Institute of Scientific and Technical Information of China (English)

    张芹; 王勇; 钱凯先

    2005-01-01

    RNA干涉(RNA interference.RNAi)可以抑制诸多真核基因的表达,小干涉RNA(small intmference RNA,siRNA)是RNA干涉的引发物,不同的siRNA可以引导不同水平的RNA干涉,不同种细胞中siRNA的寡核苷酸链的性质也有很大的不同.非编码RNA中的微小RNA(micnoRNA,miRNA)与siRNA在结构及作用方式等方面有很多区别和联系.RNAi的作用机制大致有两种:在Drosophila中的一般作用模式和在C.elegans中的扩大作用模式.利用RNA干涉技术可以通过抑制基因的表达来研究其功能;RNA干涉作为基因治疗的工具,在肝炎和AIDS的治疗过程中有一定的作用.RNAi的高特异性、高效性、放大效应和无细胞特异性等特点在科研中得到了广泛的应用.

  6. Dissecting RNA-interference pathway with small molecules.

    Science.gov (United States)

    Chiu, Ya-Lin; Dinesh, Chimmanamada U; Chu, Chia-ying; Ali, Akbar; Brown, Kirk M; Cao, Hong; Rana, Tariq M

    2005-06-01

    RNA interference (RNAi) is a process whereby short-interfering RNAs (siRNA) silence gene expression in a sequence-specific manner. We have screened a chemical library of substituted dihydropteridinones and identified a nontoxic, cell permeable, and reversible inhibitor of the RNAi pathway in human cells. Biochemical and fluorescence resonance-energy transfer experiments demonstrated that one of the compounds, named ATPA-18, inhibited siRNA unwinding that occurred within 6 hr of siRNA transfection. Extracts prepared from ATPA-18-treated cells also exhibited a decrease in target RNA cleavage by activated RNA-induced silencing complex (RISC*). Interestingly, when activated RISC*, which harbors unwound antisense siRNA, was treated with ATPA-18 in vitro, target RNA cleavage was not affected, indicating that this compound inhibited siRNA unwinding or steps upstream of unwinding in the RNAi pathway. Our results also establish the timing of siRNA unwinding and show that siRNA helicase activity is required for RNAi. ATPA-18 analogs will therefore provide a new class of small molecules for studying RNAi mechanisms in a variety of model organisms and deciphering in vivo genetic functions through reverse genetics.

  7. Managing inter-cell interference with advanced receivers and rank adaptation in 5G small cells

    DEFF Research Database (Denmark)

    Tavares, Fernando Menezes Leitão; Berardinelli, Gilberto; Catania, Davide;

    2015-01-01

    The use of receivers with interference suppression capabilities is expected to be a significant performance booster in 5th Generation (5G) ultra-dense small cell networks. In this respect, they could represent an alternative to traditional frequency reuse techniques, facilitating the inter-cell...... interference management. In this paper, we evaluate whether it is possible to rely on such advanced receivers as the main tool to deal with the inter-cell interference problem. We present a system-level performance evaluation in three different dense indoor small cell scenarios using a receiver model...... that includes both interference rejection combining (IRC) and successive interference cancellation (SIC) principles, as well as different rank adaptation strategies. Our results confirm that interference suppression receivers with a supportive system design can indeed represent a valid alternative to frequency...

  8. Targeting Th17 Cells with Small Molecules and Small Interference RNA.

    Science.gov (United States)

    Lin, Hui; Song, Pingfang; Zhao, Yi; Xue, Li-Jia; Liu, Yi; Chu, Cong-Qiu

    2015-01-01

    T helper 17 (Th17) cells play a central role in inflammatory and autoimmune diseases via the production of proinflammatory cytokines interleukin- (IL-) 17, IL-17F, and IL-22. Anti-IL-17 monoclonal antibodies show potent efficacy in psoriasis but poor effect in rheumatoid arthritis (RA) and Crohn's disease. Alternative agents targeting Th17 cells may be a better way to inhibit the development and function of Th17 cells than antibodies of blocking a single effector cytokine. Retinoic acid-related orphan receptor gamma t (RORγt) which acts as the master transcription factor of Th17 differentiation has been an attractive pharmacologic target for the treatment of Th17-mediated autoimmune disease. Recent progress in technology of chemical screen and engineering nucleic acid enable two new classes of therapeutics targeting RORγt. Chemical screen technology identified several small molecule specific inhibitors of RORγt from a small molecule library. Systematic evolution of ligands by exponential enrichment (SELEX) technology enabled target specific aptamers to be isolated from a random sequence oligonucleotide library. In this review, we highlight the development and therapeutic potential of small molecules inhibiting Th17 cells by targeting RORγt and aptamer mediated CD4(+) T cell specific delivery of small interference RNA against RORγt gene expression to inhibit pathogenic effector functions of Th17 lineage.

  9. Targeting Th17 Cells with Small Molecules and Small Interference RNA

    Directory of Open Access Journals (Sweden)

    Hui Lin

    2015-01-01

    Full Text Available T helper 17 (Th17 cells play a central role in inflammatory and autoimmune diseases via the production of proinflammatory cytokines interleukin- (IL- 17, IL-17F, and IL-22. Anti-IL-17 monoclonal antibodies show potent efficacy in psoriasis but poor effect in rheumatoid arthritis (RA and Crohn’s disease. Alternative agents targeting Th17 cells may be a better way to inhibit the development and function of Th17 cells than antibodies of blocking a single effector cytokine. Retinoic acid-related orphan receptor gamma t (RORγt which acts as the master transcription factor of Th17 differentiation has been an attractive pharmacologic target for the treatment of Th17-mediated autoimmune disease. Recent progress in technology of chemical screen and engineering nucleic acid enable two new classes of therapeutics targeting RORγt. Chemical screen technology identified several small molecule specific inhibitors of RORγt from a small molecule library. Systematic evolution of ligands by exponential enrichment (SELEX technology enabled target specific aptamers to be isolated from a random sequence oligonucleotide library. In this review, we highlight the development and therapeutic potential of small molecules inhibiting Th17 cells by targeting RORγt and aptamer mediated CD4+ T cell specific delivery of small interference RNA against RORγt gene expression to inhibit pathogenic effector functions of Th17 lineage.

  10. Experimental Verification of Interference Mitigation Techniques for 5G Small Cells

    DEFF Research Database (Denmark)

    Assefa, Dereje; Berardinelli, Gilberto; Tavares, Fernando Menezes Leitão

    2015-01-01

    Inter-cell interference is the main performance limiting factor in the dense deployment of small cells targeted by the upcoming 5th Generation (5G) radio access technology. In this paper, we present an experimental evaluation of inter-cell interference mitigation techniques in a real indoor office...

  11. Experimental Evaluation of Interference Suppression Receivers and Rank Adaptation in 5G Small Cells

    DEFF Research Database (Denmark)

    Assefa, Dereje; Berardinelli, Gilberto; Catania, Davide;

    2015-01-01

    Advanced receivers are a key component of the 5th Generation (5G) ultra-dense small cells concept given their capability of efficiently dealing with the ever-increasing problem of inter-cell interference. In this paper, we evaluate the potential of interference suppression receivers in real network...... the Interference Rejection Combining (IRC) and Successive Interference Cancellation (SIC) receivers and different rank adaptation approaches. Each node in our software defined radio (SDR) testbed features a 22 MIMO transceiver built with the USRP N200 hardware by Ettus Research. Our experimental results confirm...

  12. Experimental Evaluation of Interference Rejection Combining for 5G small cells,

    DEFF Research Database (Denmark)

    Assefa, Dereje; Berardinelli, Gilberto; Tavares, Fernando Menezes Leitão

    2015-01-01

    The Interference Rejection Combining (IRC) receiver can significantly boost the network throughput in scenarios characterized by dense uncoordinated deployment of small cells, as targeted by future 5th generation (5G) radio access technology. This paper presents an experimental study...

  13. Interference characterization and mitigation benefit analysis for LTE-A macro and small cell deployments

    DEFF Research Database (Denmark)

    Lopez, Victor Fernandez; Pedersen, Klaus I.; Soret, Beatriz

    2015-01-01

    are densely deployed. Thus, the main interference characteristics of the macro layer and the dense small cell layer are studied separately. Moreover, the potential benefit of mitigating the dominant interferer in such scenarios is quantified as an upper bound gain and its time variability is discussed...... is such that 30% of the users could achieve at least a 50% throughput gain if said interferer were mitigated, with some users reaching a 300% improvement during certain time intervals. All the mentioned metrics are remarkably similar in the macro and small cell deployments, which suggests that densification does...

  14. The Inter-Cell Interference Dilemma in Dense Outdoor Small Cell Deployment

    DEFF Research Database (Denmark)

    Polignano, Michele; Mogensen, Preben; Fotiadis, Panagiotis

    2014-01-01

    The deployment of low-power small cells is envisaged as the main driver to accommodate the mobile broadband traffic growth in cellular networks. Depending on the spatial distribution of the user traffic, a densification of the small cells may be required in confined areas. However, deploying more...... does not effect the user throughput and no interference coordination is required. On the other hand, if deployed in open areas (e.g. city squares) the interference coordination enhances both average and coverage user throughput in case of high network load condition.......The deployment of low-power small cells is envisaged as the main driver to accommodate the mobile broadband traffic growth in cellular networks. Depending on the spatial distribution of the user traffic, a densification of the small cells may be required in confined areas. However, deploying more...... and more cells in given areas may imply an increase of the inter-cell interference among the small cells. This study aims at investigating if the inter-cell interference among outdoor small cells may represent an impairment to the user experience, and evaluates if and in what conditions the interference...

  15. An Interference-Aware Distributed Transmission Technique for Dense Small Cell Networks

    DEFF Research Database (Denmark)

    Mahmood, Nurul Huda; Berardinelli, Gilberto; Pedersen, Klaus I.

    2015-01-01

    transmission technique that can efficiently manage the interference in an uncoordinated dense small cell network is investigated in this work. The proposed interference aware scheme only requires instantaneous channel state information at the transmitter end towards the desired receiver. Motivated by penalty...... methods in optimization studies, an interference dependent weighting factor is introduced to control the number of parallel transmission streams. The proposed scheme can outperform a more complex benchmark transmission scheme in terms of the sum network throughput in certain scenarios and with realistic...

  16. Interference-Robust Air Interface for 5G Ultra-dense Small Cells

    DEFF Research Database (Denmark)

    Tavares, Fernando Menezes Leitão; Berardinelli, Gilberto; Mahmood, Nurul Huda

    2016-01-01

    An ultra-dense deployment of small cells is foreseen as the solution to cope with the exponential increase of the data rate demand targeted by the 5th Generation (5G) radio access technology. In this article, we propose an interference-robust air interface built upon the usage of advanced receivers...

  17. Observation of small sub-pulses out of the delayed-interference signal-wavelength converter

    DEFF Research Database (Denmark)

    Sakaguchi, J.; Nielsen, Mads Lønstrup; Ohira, T.;

    2005-01-01

    The generation of small sub-pulses in the delayed-interference signal-wavelength converter (DISC), which has been studied for use in future 160-Gb/s optical time division multiplexing-wavelength division multiplexing (OTDM-WDM) communication systems, was recently predicted as a potential problem....

  18. A method for aircraft magnetic interference compensation based on small signal model and LMS algorithm

    Institute of Scientific and Technical Information of China (English)

    Zhou Jianjun; Lin Chunsheng; Chen Hao

    2014-01-01

    Aeromagnetic interference could not be compensated effectively if the precision of parameters which are solved by the aircraft magnetic field model is low. In order to improve the compensation effect under this condition, a method based on small signal model and least mean square (LMS) algorithm is proposed. According to the method, the initial values of adaptive filter’s weight vector are calculated with the solved model parameters through small signal model at first, then the small amount of direction cosine and its derivative are set as the input of the filter, and the small amount of the interference is set as the filter’s expected vector. After that, the aircraft mag-netic interference is compensated by LMS algorithm. Finally, the method is verified by simulation and experiment. The result shows that the compensation effect can be improved obviously by the LMS algorithm when original solved parameters have low precision. The method can further improve the compensation effect even if the solved parameters have high precision.

  19. Interference Mitigation and Sum Rate Optimization for MIMO Downlink Small Cells

    Directory of Open Access Journals (Sweden)

    H. H. Kha

    2016-12-01

    Full Text Available This paper addresses interference issues in multiuser multiple-input multiple-output (MIMO downlink heterogeneous networks in which multiple small cells are deployed in macrocell coverage. With the higher priority to access the frequency bands, the macro base station (MBS will exploit eigenmode transmission along with water-filling based power allocation to maximize its data rate. To avoid harmful interference to macro users, we propose structures of the precoders at the small cell BSs (SBSs as cascades of two precoding matrices. In addition, to mitigate intra-tier inference in small cells, the SBSs exploit the user scheduling schemes for their associated users. We investigate two user scheduling schemes using the minimum interference leakage and maximum signal to noise ratio criteria. The sum rate of the selected users can be further improved by power allocation. We develop an iterative algorithm using difference of convex functions (d.c. programming to tackle the mathematical challenges of the nonconvex power allocation problem, Numerical simulation results show that the proposed strategy outperforms the conventional methods in terms of the achievable sum rate.

  20. Low-Complexity Interference-Free Downlink Channel Assignment with Improved Performance in Coordinated Small Cells

    KAUST Repository

    Radaydeh, Redha M.

    2015-05-01

    This paper proposes a low-complexity interference-free channel assignment scheme with improved desired downlink performance in coordinated multi-antenna small-coverage access points (APs) that employ the open-access control strategy. The adopted system treats the case when each user can be granted an access to one of the available channels at a time. Moreover, each receive terminal can suppress a limited number of resolvable interfering sources via its highly-correlated receive array. On the other hand, the operation of the deployed APs can be coordinated to serve active users, and the availability of multiple physical channels and the use of uncorrelated transmit antennas at each AP are exploited to improve the performance of supported users. The analysis provides new approaches to use the transmit antenna array at each AP, the multiple physical channels, the receive antenna array at each user in order to identify interference-free channels per each user, and then to select a downlink channel that provides the best possible improved performance. The event of concurrent interference-free channel identification by different users is also treated to further improve the desired link associated with the scheduled user. The analysis considers the practical scenario of imperfect identification of interference-free channel by an active user and/or the imperfectness in scheduling concurrent users requests on the same channel. The developed formulations can be used to study any performance metric and they are applicable for any statistical and geometric channel models. © 2015 IEEE.

  1. Interference with phage lambda development by the small subunit of the phage 21 terminase, gp1.

    OpenAIRE

    1991-01-01

    Bacteriophage lambda development is blocked in cells carrying a plasmid that expresses the terminase genes of phage 21. The interference is caused by the small subunit of phage 21 terminase, gp1. Mutants of lambda able to form plaques in the presence of gp1 include sti mutants. One such mutation, sti30, is an A. T-to-G.C transition mutation at base pair 184 on the lambda chromosome. The sti30 mutation extends the length of the ribosome-binding sequence of the Nul gene that is complementary to...

  2. Improved Interference-Free Channel Allocation in Coordinated Multiuser Multi-Antenna Open-Access Small Cells

    KAUST Repository

    Radaydeh, Redha

    2016-02-16

    This paper investigates low-complexity joint interference avoidance and desired link improvement for single channel allocation in multiuser multi-antenna access points (APs) for open-access small cells. It is considered that an active user is equipped with an atenna array that can be used to suppress interference sources but not to provide spatial diversity. On the other hand, the operation of APs can be coordinated to meet design requirements, and each of which can unconditionally utilize assigned physical channels. Moreover, each AP is equipped with uncorrelated antennas that can be reused simultaneously to serve many active users. The analysis provides new approaches to exploit physical channels, transmit antennas, and APs to mitigate interference, while providing the best possible link gain to an active user through the most suitable interference-free channel. The event of concurrent service requests placed by active users on a specific interference-free channel is discussed for either interference avoidance through identifying unshared channels or desired link improvement via multiuser scheduling. The applicability of the approaches to balance downlink loads is explained, and practical scenarios due to imperfect identification of interference-free channels and/or scheduled user are thoroughly investigated. The developed results are applicable for any statistical and geometric models of the allocated channel to an active user as well as channel conditions of interference users. They can be used to study various performance measures. Numerical and simulation results are presented to explain some outcomes of this work.

  3. Inhibition of full length Hepatitis C Virus particles of 1a genotype through small interference RNA

    Directory of Open Access Journals (Sweden)

    Rehman Sidra

    2011-05-01

    Full Text Available Abstract Background Hepatitis C virus (HCV, a member of the Flaviviridae family of viruses, is a major cause of chronic hepatitis, liver cirrhosis and hepatocellular carcinoma. Currently, the only treatment available consists of a combination of Pegylated interferon alpha (INF-α and ribavirin, but only half of the patients treated show a sufficient antiviral response. Thus there is a great need for the development of new treatments for HCV infections. RNA interference (RNAi represents a new promising approach to develop effective antiviral drugs and has been extremely effective against HCV infection. Results This study was design to assess or explore the silencing effect of small interference RNAs (siRNAs against full length HCV particles of genotype 1a. In the present study six 21-bp siRNAs were designed against different regions of HCV structural genes (Core, E1 and E2. Selected siRNAs were labeled as Csi 301, Csi 29, E1si 52, E1si 192, E2si 86 and E2si 493. Our results demonstrated that siRNAs directed against HCV core gene showed 70% reduction in viral titer in HCV infected liver cells. Moreover, siRNAs against E1 and E2 envelop genes showed a dramatic reduction in HCV viral RNA, E2si 86 exhibited 93% inhibition, while E1si 192, E2si 493 and E1si 52 showed 87%, 80%, and 66% inhibition respectively. No significant inhibition was detected in cells transfected with the negative control siRNA. Conclusion Our results suggested that siRNAs targeted against HCV structural genes efficiently silence full length HCV particles and provide an effective therapeutic option against HCV infection.

  4. A simple and efficient method to transfect small interference RNA into bovine SCNT embryos.

    Science.gov (United States)

    Zhang, Hui; Wang, LiJun; Li, WenZhe; Mao, QingFu; Wang, YongSheng; Li, Qian; Hua, Song; Zhang, Yong

    2015-10-01

    RNA interference is an important tool to study the gene function. Microinjection and electroporation are usually used to transfer DNA, small interference RNA (siRNA), morpholinos, and protein into oocytes or embryos. This study used a simple and effective method to transfect siRNA into bovine somatic cell nuclear transfer (SCNT) embryos. In this method, siRNA transfection and electrofusion of SCNT were combined. A pair of platinum microelectrodes was used during SCNT to complete electrofusion. A CY3-labeled siRNA-targeted DNA methyltransferase-1 (DNMT1) was chosen to verify the siRNA transfection efficiency of this approach. First, a suitable concentration of siRNA was mixed with Zimmermann's fusion medium. Reconstructed embryos were then added into the microdrops of the mixed fusion medium to simultaneously transfect the siRNA and electrofuse the SCNT embryos. Our results showed that transfecting DNMT1 siRNA via the proposed method caused obvious CY3 fluorescence and significant downregulation of DNMT1 messenger RNA, DNMT1 protein, and global DNA methylation levels in the SCNT embryos. Meanwhile, the survival rate after electrofusion (90.4% vs. 89.4% vs. 89.1%, P > 0.05) and developmental rates of the SCNT embryos (72.8% vs. 74.9% vs. 72.4%, P > 0.05; 29.7% vs. 31.7% vs. 29.7%, P > 0.05) were not significantly affected. In summary, siRNAs were effectively transfected into the SCNT embryos via the proposed method and exert their functions, and the normal development of preimplantation SCNT embryos was not affected by the method used.

  5. Interference statistics and capacity analysis for uplink transmission in two-tier small cell networks: A geometric probability approach

    KAUST Repository

    Tabassum, Hina

    2014-07-01

    This paper presents a novel framework to derive the statistics of the interference considering dedicated and shared spectrum access for uplink transmission in two-tier small cell networks such as the macrocell-femtocell networks. The framework exploits the distance distributions from geometric probability theory to characterize the uplink interference while considering a traditional grid-model set-up for macrocells along with the randomly deployed femtocells. The derived expressions capture the impact of path-loss, composite shadowing and fading, uniform and non-uniform traffic loads, spatial distribution of femtocells, and partial and full spectral reuse among femtocells. Considering dedicated spectrum access, first, we derive the statistics of co-tier interference incurred at both femtocell and macrocell base stations (BSs) from a single interferer by approximating generalized- K composite fading distribution with the tractable Gamma distribution. We then derive the distribution of the number of interferers considering partial spectral reuse and moment generating function (MGF) of the cumulative interference for both partial and full spectral reuse scenarios. Next, we derive the statistics of the cross-tier interference at both femtocell and macrocell BSs considering shared spectrum access. Finally, we utilize the derived expressions to analyze the capacity in both dedicated and shared spectrum access scenarios. The derived expressions are validated by the Monte Carlo simulations. Numerical results are generated to assess the feasibility of shared and dedicated spectrum access in femtocells under varying traffic load and spectral reuse scenarios. © 2014 IEEE.

  6. Performance improvement of switched-based interference mitigation for channel assignment in over-loaded small-cell networks

    KAUST Repository

    Gaaloul, Fakhreddine

    2013-05-01

    This paper proposes adequate methods to improve the interference mitigation capability of a recently investigated switched-based interference reduction scheme for single downlink channel assignment in over-loaded small-cell networks. The model assumes that the available orthogonal channels for small cells are distributed among access points in close vicinity, where each access point knows its allocated channels a priori. Each cell has a single antenna, employs the open access strategy, and can reuse its allocated channels simultaneously, while scheduling concurrent service requests. Moreover, the access points can not coordinate their transmissions, and can receive limited feedback from active users. The paper presents low-complexity schemes to identify a suitable channel to serve the scheduled user by maintaining the interference power level within a tolerable range. They attempt to either complement the switched-based scheme by minimum interference channel selection or adopt different interference thresholds on available channels, while reducing the channel examination load. The optimal thresholds for interference mitigation at the desired receive station are quantified for various performance criteria. The performance and processing load of the proposed schemes are obtained analytically, and then compared to those of the single-threshold scheme via numerical and simulation results. © 2002-2012 IEEE.

  7. An Empirical Study of Overlapping Rotor Interference for a Small Unmanned Aircraft Propulsion System

    Directory of Open Access Journals (Sweden)

    Mantas Brazinskas

    2016-10-01

    Full Text Available The majority of research into full-sized helicopter overlapping propulsion systems involves co-axial setups (fully overlapped. Partially overlapping rotor setups (tandem, multirotor have received less attention, and empirical data produced over the years is limited. The increase in demand for compact small unmanned aircraft has exposed the need for empirical investigations of overlapping propulsion systems at a small scale (Reynolds Number < 250,000. Rotor-to-rotor interference at the static state in various overlapping propulsion system configurations was empirically measured using off the shelf T-Motor 16 inch × 5.4 inch rotors. A purpose-built test rig was manufactured allowing various overlapping rotor configurations to be tested. First, single rotor data was gathered, then performance measurements were taken at different thrust and tip speeds on a range of overlap configurations. The studies were conducted in a system torque balance mode. Overlapping rotor performance was compared to an isolated dual rotor propulsion system revealing interference factors which were compared to the momentum theory. Tests revealed that in the co-axial torque-balanced propulsion system the upper rotor outperforms the lower rotor at axial separation ratios between 0.05 and 0.85. Additionally, in the same region, thrust sharing between the two rotors changed by 21%; the upper rotor produced more thrust than the lower rotor at all times. Peak performance was recorded as a 22% efficiency loss when the axial separation ratio was greater than 0.25. The performance of a co-axial torque-balanced system reached a 27% efficiency loss when the axial separation ratio was equal to 0.05. The co-axial system swirl recovery effect was recorded to have a 4% efficiency gain in the axial separation ratio region between 0.05 and 0.85. The smallest efficiency loss (3% was recorded when the rotor separation ratio was between 0.95 and 1 (axial separation ratio was kept at 0

  8. Small interference RNA targeting vascular endothelial growth factor gene effectively attenuates retinal neovascularization in mice model

    Institute of Scientific and Technical Information of China (English)

    KONG Yi-chun; SUN Bei; ZHAO Kan-xing; HAN Mei; WANG Yu-chuan

    2013-01-01

    Background The mechanism of retinal neovascularization is not understood completely.Many growth factors are involved in the process of retinal neovascularization,such as vascular endothelial growth factor (VEGF) and pigment epithelium-deprived factor (PEDF),which are the representatives of angiogenic and antiangiogenic molecules respectively.Oxygen induced retinopathy (OIR) is a useful model to investigate retinal neovascularization.The present study was conducted to investigate the feasibility of small interference RNA (siRNA) targeting VEGF gene in attenuating oxygen induced retinopathy (OIR) by regulating VEGF to PEDF ratio (VEGF/PEDF).Methods In vitro,cultured EOMA cells were transfected with VEGF-siRNA (psi-HITM/EGFPNEGF siRNA) and LipofectamineTM 2000 for 24,48,and 72 hours,respectively.Expression of VEGF mRNA was evaluated by real time polymerase chain reaction (PCR) and the level of VEGF protein was analyzed by Western blotting.In vivo,OIR model mice were established,the mice (C57BL/6J) received an intra-vitreal injection of 1 μl of mixture of psi-HITM/EGFPNEGF siRNA and Lipofectamine 2000.Expressions of retinal VEGF and PEDF protein were measured by Western blotting,retinal neovascularization was observed by fluorescein angiography,and quantified.Results In vitro psi-HITM/EGFP/VEGF siRNA treatment significantly reduced VEGF mRNA and protein expression.In vivo,with decreased VEGF and VEGF-PEDF ratio,significant attenuation of neovascular tufts,avascular regions,tortuous,and dilated blood vessels were observed in the interfered animals.Conclusions VEGF plays an important role in OIR,and the transfection of VEGF-siRNA can effectively downregulate VEGF expression in vivo,accompanied by the downregulation of VEGF-PEDF ratio,and simultaneous attenuation of retinal neovascularization was also observed.These findings suggest that VEGF/PEDF may serve as a potential target in the treatment of retinal neovascularization and RNA interference targeting VEGF expression

  9. Small Interference RNA Targeting TLR4 Gene Effectively Attenuates Pulmonary Inflammation in a Rat Model

    Directory of Open Access Journals (Sweden)

    Feixiang Wu

    2012-01-01

    Full Text Available Objective. The present study was to investigate the feasibility of adenovirus-mediated small interference RNA (siRNA targeting Toll-like receptor 4 (TLR4 gene in ameliorating lipopolysaccharide- (LPS- induced acute lung injury (ALI. Methods. In vitro, alveolar macrophages (AMs were treated with Ad-siTLR4 and Ad-EFGP, respectively, for 12 h, 24 h, and 48 h, and then with LPS (100 ng/mL for 2 h, and the function and expression of TLR4 were evaluated. In vivo, rats received intratracheal injection of 300 μL of normal saline (control group, 300 μL of Ad-EGFP (Ad-EGFP group, or 300 μL of Ad-siTLR4 (Ad-siTLR4 group and then were intravenously treated with LPS (50 mg/kg to induce ALI. Results. Ad-siTLR4 treatment significantly reduced TLR4 expression and production of proinflammatory cytokines following LPS treatment both in vitro and in vivo. Significant alleviation of tissue edema, microvascular protein leakage, and neutrophil infiltration was observed in the AdsiTLR4-treated animals. Conclusion. TLR4 plays a critical role in LPS-induced ALI, and transfection of Ad-siTLR4 can effectively downregulate TLR4 expression in vitro and in vivo, accompanied by alleviation of LPS-induced lung injury. These findings suggest that TLR4 may serve as a potential target in the treatment of ALI and RNA interfering targeting TLR4 expression represents a therapeutic strategy.

  10. Small interference RNA targeting tissue factor inhibits human lung adenocarcinoma growth in vitro and in vivo

    Directory of Open Access Journals (Sweden)

    Wang Jianing

    2011-05-01

    Full Text Available Abstract Background The human coagulation trigger tissue factor (TF is overexpressed in several types of cancer and involved in tumor growth, vascularization, and metastasis. To explore the role of TF in biological processes of lung adenocarcinoma, we used RNA interference (RNAi technology to silence TF in a lung adenocarcinoma cell line A549 with high-level expression of TF and evaluate its antitumor effects in vitro and in vivo. Methods The specific small interfering RNA (siRNA designed for targeting human TF was transfected into A549 cells. The expression of TF was detected by reverse transcription-PCR and Western blot. Cell proliferation was measured by MTT and clonogenic assays. Cell apoptosis was assessed by flow cytometry. The metastatic potential of A549 cells was determined by wound healing, the mobility and Matrigel invasion assays. Expressions of PI3K/Akt, Erk1/2, VEGF and MMP-2/-9 in transfected cells were detected by Western blot. In vivo, the effect of TF-siRNA on the growth of A549 lung adenocarcinoma xenografts in nude mice was investigated. Results TF -siRNA significantly reduced the expression of TF in the mRNA and protein levels. The down-regulation of TF in A549 cells resulted in the suppression of cell proliferation, invasion and metastasis and induced cell apoptosis in dose-dependent manner. Erk MAPK, PI3K/Akt pathways as well as VEGF and MMP-2/-9 expressions were inhibited in TF-siRNA transfected cells. Moreover, intratumoral injection of siRNA targeting TF suppressed the tumor growth of A549 cells in vivo model of lung adenocarcinoma. Conclusions Down-regulation of TF using siRNA could provide a potential approach for gene therapy against lung adenocarcinoma, and the antitumor effects may be associated with inhibition of Erk MAPK, PI3K/Akt pathways.

  11. A Small U-Shaped Bending-Induced Interference Optical Fiber Sensor for the Measurement of Glucose Solutions.

    Science.gov (United States)

    Fang, Yu-Lin; Wang, Chen-Tung; Chiang, Chia-Chin

    2016-09-09

    The study proposes a small U-shaped bending-induced interference optical fiber sensor; this novel sensor is a probe-type sensor manufactured using a mechanical device, a heat source, optical fiber and a packaging module. This probe-type sensor overcomes the shortcomings of conventional optical fibers, including being difficult to repair and a tendency to be influenced by external forces. We manufactured three types of sensors with different curvature radiuses. Specifically, sensors with three radiuses (1.5 mm, 2.0 mm, and 3.0 mm) were used to measure common water and glucose solutions with concentrations of between 6% and 30% (the interval between concentrations was 4%). The results show that the maximal sensitivity was 0.85 dB/% and that the linearly-dependent coefficient was 0.925. The results further show that not only can the small U-shaped bending-induced interference optical fiber sensor achieve high sensitivity in the measurement of glucose solutions, but that it can also achieve great stability and repeatability.

  12. New perspectives on the diversification of the RNA interference system: insights from comparative genomics and small RNA sequencing.

    Science.gov (United States)

    Burroughs, Alexander Maxwell; Ando, Yoshinari; Aravind, L

    2014-01-01

    Our understanding of the pervasive involvement of small RNAs in regulating diverse biological processes has been greatly augmented by recent application of deep-sequencing technologies to small RNA across diverse eukaryotes. We review the currently known small RNA classes and place them in context of the reconstructed evolutionary history of the RNA interference (RNAi) protein machinery. This synthesis indicates that the earliest versions of eukaryotic RNAi systems likely utilized small RNA processed from three types of precursors: (1) sense-antisense transcriptional products, (2) genome-encoded, imperfectly complementary hairpin sequences, and (3) larger noncoding RNA precursor sequences. Structural dissection of PIWI proteins along with recent discovery of novel families (including Med13 of the Mediator complex) suggest that emergence of a distinct architecture with the N-terminal domains (also occurring separately fused to endoDNases in prokaryotes) formed via duplication of an ancestral unit was key to their recruitment as primary RNAi effectors and use of small RNAs of certain preferred lengths. Prokaryotic PIWI proteins are typically components of several RNA-directed DNA restriction or CRISPR/Cas systems. However, eukaryotic versions appear to have emerged from a subset that evolved RNA-directed RNAi. They were recruited alongside RNaseIII domains and RNA-dependent RNA polymerase (RdRP) domains, also from prokaryotic systems, to form the core eukaryotic RNAi system. Like certain regulatory systems, RNAi diversified into two distinct but linked arms concomitant with eukaryotic nucleocytoplasmic compartmentalization. Subsequent elaboration of RNAi proceeded via diversification of the core protein machinery through lineage-specific expansions and recruitment of new components from prokaryotes (nucleases and small RNA-modifying enzymes), allowing for diversification of associating small RNAs. © 2013 John Wiley & Sons, Ltd.

  13. Gene suppression via U1 small nuclear RNA interference (U1i) machinery using oligonucleotides containing 2'-modified-4'-thionucleosides.

    Science.gov (United States)

    Kikuchi, Yusaku; Yamazaki, Naoshi; Tarashima, Noriko; Furukawa, Kazuhiro; Takiguchi, Yoshiharu; Itoh, Kohji; Minakawa, Noriaki

    2013-09-01

    Gene suppression via U1 small nuclear RNA interference (U1i) is considered to be one of the most attractive approaches, and takes the place of general antisense, RNA interference (RNAi), and anti-micro RNA machineries. Since the U1i can be induced by short oligonucleotides (ONs), namely U1 adaptors consisting of a 'target domain' and a 'U1 domain', we prepared adaptor ONs using 2'-modified-4'-thionucleosides developed by our group, and evaluated their U1i activity. As a result, the desired gene suppression via U1i was observed in ONs prepared as a combination of 2'-fluoro-4'-thionucleoside and 2'-fluoronucleoside units as well as only 2'-fluoronucleoside units, while those prepared as combination of 2'-OMe nucleoside/2'-OMe-4'-thionucleoside and 2'-fluoronucleoside units did not show significant activity. Measurement of Tm values indicated that a higher hybridization ability of adaptor ONs with complementary RNA is one of the important factors to show potent U1i activity.

  14. Comparison of dengue virus type 2-specific small RNAs from RNA interference-competent and -incompetent mosquito cells.

    Directory of Open Access Journals (Sweden)

    Jaclyn C Scott

    Full Text Available The exogenous RNA interference (RNAi pathway is an important antiviral defense against arboviruses in mosquitoes, and virus-specific small interfering (siRNAs are key components of this pathway. Understanding the biogenesis of siRNAs in mosquitoes could have important ramifications in using RNAi to control arbovirus transmission. Using deep sequencing technology, we characterized dengue virus type 2 (DENV2-specific small RNAs produced during infection of Aedes aegypti mosquitoes and A. aegypti Aag2 cell cultures and compared them to those produced in the C6/36 Aedes albopictus cell line. We show that the size and mixed polarity of virus-specific small RNAs from DENV-infected A. aegypti cells indicate that they are products of Dicer-2 (Dcr2 cleavage of long dsRNA, whereas C6/36 cells generate DENV2-specific small RNAs that are longer and predominantly positive polarity, suggesting that they originate from a different small RNA pathway. Examination of virus-specific small RNAs after infection of the two mosquito cell lines with the insect-only flavivirus cell fusing agent virus (CFAV corroborated these findings. An in vitro assay also showed that Aag2 A. aegypti cells are capable of siRNA production, while C6/36 A. albopictus cells exhibit inefficient Dcr2 cleavage of long dsRNA. Defective expression or function of Dcr2, the key initiator of the RNAi pathway, might explain the comparatively robust growth of arthropod-borne viruses in the C6/36 cell line, which has been used frequently as a surrogate for studying molecular interactions between arboviruses and cells of their mosquito hosts.

  15. Kinases required in hepatitis C virus entry and replication highlighted by small interference RNA screening.

    Science.gov (United States)

    Trotard, Maud; Lepère-Douard, Charlotte; Régeard, Morgane; Piquet-Pellorce, Claire; Lavillette, Dimitri; Cosset, François-Loic; Gripon, Philippe; Le Seyec, Jacques

    2009-11-01

    The entry pathway of the hepatitis C virus (HCV), a major human pathogen, into the cell is incompletely defined. To better characterize this viral life cycle stage, we screened a small interfering RNA library dedicated to the membrane trafficking and remodeling with the infection model of Huh-7.5.1 cells by HCV pseudoparticles (HCVpp). Results showed that the down-regulation of different factors implied in clathrin-mediated endocytosis (CME) inhibits HCVpp cell infection. In addition, knockdown of the phosphatidylinositol 4-kinase type III-alpha (PI4KIIIalpha) prevented infection by HCVpp or by cell-culture grown JFH-1-based HCV. Moreover, the replication activity of an HCV replicon was also affected by the PI4KIIIalpha knockdown. Additional investigations on the different members of the PI4K family revealed that the presence of PI4KIIIbeta in the host cells influenced their susceptibility to HCVpp infection and their capacity to sustain the HCV replication. The PI4KIII involvement during the HCV life cycle seemed to occur by other ways than the control of the CME or of the membranous expression of HCV receptors. Finally, our library screening completed data on the CME-dependant entry route of HCV and identified 2 kinases, PI4KIIIalpha and beta, as relevant potential therapeutic targets.

  16. Post-transcriptional inhibition of hepatitis C virus replication through small interference RNA

    Directory of Open Access Journals (Sweden)

    Rehman Sidra

    2011-03-01

    Full Text Available Abstract Background Hepatitis C Virus (HCV infection is a major health problem throughout world that causes acute and chronic infection which resulted in liver fibrosis, hepatocellular carcinoma and death. The only therapy currently available for HCV infection is the combination of pegylated interferon alpha (PEG-IFN α and ribavirin. This therapy can effectively clear the virus infection in only 50% of infected individuals. Hence, there is a dire need to develop antiviral agents against HCV. Results This study was design to examine the ability of exogenous small interfering RNAs (siRNAs to block the replication of HCV in human liver cells. In the present study six 21-bp siRNAs were designed against different regions of HCV non-structural genes (NS2, NS3 serine protease/helicase, NS4Band NS5B RNA dependent RNA polymerase. siRNAs were labeled as NS2si241, NS3si-229, NS3si-858, NS4Bsi-166, NS5Bsi-241 and NS5Bsi-1064. We found that siRNAs against HCV NS2- NS5B efficiently inhibit HCV replication in Huh-7 cells. Our results demonstrated that siRNAs directed against HCV NS3 (NS3si-229 and NS3si-858 showed 58% and 88% reduction in viral titer respectively. Moreover, NS4Bsi-166 and NS5Bsi-1064 exhibited a dramatic reduction in HCV viral RNA and resulted in greater than 90% inhibition at a 20 μM concentration, while NS2si-241 showed 27% reduction in viral titer. No significant inhibition was detected in cells transfected with the negative control siRNA. Conclusion Our results suggest that siRNAs targeting against HCV non-structural genes (NS2-NS5B efficiently inhibit HCV replication and combination of these siRNAs of different targets and interferon will be better option to treat HCV infection throughout the world.

  17. A particular set of small non-coding RNAs is bound to the distinctive Argonaute protein of Trypanosoma cruzi: insights from RNA-interference deficient organisms.

    Science.gov (United States)

    Garcia-Silva, Maria Rosa; Sanguinetti, Julia; Cabrera-Cabrera, Florencia; Franzén, Oscar; Cayota, Alfonso

    2014-04-01

    The study of small RNAs and Argonaute proteins in eukaryotes that are deficient in functional RNA interference could provide insights into novel functions of small RNAs. In this study we describe small non-coding RNAs bound to a distinctive Argonaute protein of Trypanosoma cruzi, TcPIWI-tryp. Co-immunoprecipitation of TcPIWI-tryp followed by deep sequencing of isolated RNA identified abundant small RNAs derived from rRNAs and tRNAs. The small RNA repertoire differed from that of the canonical Argonaute in organisms with functional RNA interference, which could indicate novel biological functions for TcPIWI-tryp in T. cruzi and other members of the trypanosomatid clade.

  18. Reversal of chemoresistance with small interference RNA (siRNA) in etoposide resistant acute myeloid leukemia cells (HL-60).

    Science.gov (United States)

    Kachalaki, Saeed; Baradaran, Behzad; Majidi, Jafar; Yousefi, Mehdi; Shanehbandi, Dariush; Mohammadinejad, Sina; Mansoori, Behzad

    2015-10-01

    Overexpression of ATP-binding cassette (ABC) drug transporters is a major barrier in the success of cancer chemotherapy. One way to overcome overexpression of ABC drug transporter-mediated chemoresistance in acute myeloid leukemia is to suppress ABC drug transporter genes expression by small interference RNA (siRNA). In this study was assessed the involvement of ABCB1 gene in the mechanisms of resistance to etoposide in AML cells. The etoposide-resistant HL-60 cells were generated by stepwise exposure increasing concentrations of etoposide. The etoposide-resistant HL-60 cells were transfected with siRNAs using Transfection Reagent. The ABCB1 mRNA expression were assessed by real-time quantitative PCR. The MDR1/P-gp levels were measured by Western blotting. The sensitivity of resistant HL-60 cells to etoposide after transfection was determined using MTT assay. Apoptosis of resistant HL-60 cells after transfection was detected by flow cytometer. It was found that siRNA effectively inhibited ABCB1 expression at both mRNA and protein levels. Knockdown of the ABCB1 gene correlated with increased sensitivity of the resistant HL-60 cells to etoposide and was observed to lower the cytotoxic index (IC50 etoposide value) after transfection. Our results indicate that product of the ABCB1 gene have effective role in resistance to etoposide in acute myeloid leukemia cells. Copyright © 2015. Published by Elsevier Masson SAS.

  19. Adaptive interference-aware multichannel assignment for shared overloaded small-cell access points under limited feedback

    KAUST Repository

    Radaydeh, Redha Mahmoud

    2014-02-01

    This paper proposes a reduced-complexity multichannel assignment scheme for short-range cellular systems. It treats the scenario when a number of small-cell (e.g., femtocell) access points (APs) can be shared to serve active scheduled users. The APs employ isotropic antenna arrays and operate using an open-access control strategy. To improve the reuse ratio of physical resources, the APs are assumed to occupy a single physical channel, wherein coordination among them is infeasible. On the other hand, to improve the spatial coverage, a scheduled user can be served by a single transmit channel from an AP at a time. For the case of overloaded APs and when the feedback links are capacity limited, the scheme attempts to identify the suitable transmit channels from the deployed APs in an adaptive manner such that certain performance and/or processing load limits are satisfied. The effects of some system and design parameters on the outcomes of the scheme are thoroughly discussed. Novel results for the statistics of the resulting interference power are presented, from which results for some performance measures and processing loads are obtained. Numerical and simulations results are provided to clarify the achieved gains, as compared with related models under different operating conditions. © 2013 IEEE.

  20. Down-regulation of Mcl-1 by small interference RNA induces apoptosis and sensitizes HL-60 leukemia cells to etoposide.

    Science.gov (United States)

    Karami, Hadi; Baradaran, Behzad; Esfehani, Ali; Sakhinia, Masoud; Sakhinia, Ebrahim

    2014-01-01

    Acute myeloid leukemia (AML) is a fatal hematological malignancy which is resistant to a variety of chemotherapy drugs. Myeloid cell leukemia-1 (Mcl-1), a death-inhibiting protein that regulates apoptosis, has been shown to be overexpressed in numerous malignancies. In addition, it has been demonstrated that the expression level of the Mcl-1 gene increases at the time of leukemic relapse following chemotherapy. The aim of this study was to target Mcl-1 by small interference RNA (siRNA) and analyze its effects on survival and chemosensitivity of acute myeloid leukemia cell line HL-60. siRNA transfection was performed with a liposome approach. The expression levels of mRNA and protein were measured by real-time quantitative PCR and Western blot analysis, respectively. Trypan blue assays were performed to evaluate tumor cell growth after siRNA transfection. The cytotoxic effects of Mcl-1 siRNA (siMcl-1) and etoposide were determined using MTT assay on their own and in combination. Apoptosis was quantified using a DNA-histone ELISA assay. Transfection with siMcl-1 significantly suppressed the expression of Mcl-1 mRNA and protein in a time- dependent manner, resulting in strong growth inhibition and spontaneous apoptosis. Surprisingly, pretreatment with siMcl-1 synergistically enhanced the cytotoxic effect of etoposide. Furthermore, Mcl-1 down-regulation significantly increased apoptosis sensitivity to etoposide. No significant biological effects were observed with negative control siRNA treatment. Our results suggest that specific suppression of Mcl-1 by siRNA can effectively induce apoptosis and overcome chemoresistance of leukemic cells. Therefore, siMcl-1 may be a potent adjuvant in leukemia chemotherapy.

  1. INHIBITION OF PROLIFERATION OF HUMAN BREAST CANCER MCF-7 CELLS BY SMALL INTERFERENCE RNA AGAINST LRP16 GENE

    Institute of Scientific and Technical Information of China (English)

    韩为东; 赵亚力; 李琦; 母义明; 李雪; 宋海静; 陆祖谦

    2004-01-01

    Objective: Our previous studies have firstly demonstrated that 17(-E2 up-regulates LRP16 gene expression in human breast cancer MCF-7 cells, and ectopic expression of the LRP16 gene promotes MCF-7 cells proliferation. Here, the effects of the LRP16 gene expression on growth of MCF-7 human breast cancer cells and the mechanism were further studied by establishing two stably LRP16-inhibitory MCR-7 cell lines. Methods: Hairpin small interference RNA (siRNA) strategy, by which hairpin siRNA was released by U6 promoter and was mediated by pLPC-based retroviral vector, was adopted to knockdown endogenous LRP16 level in MCF-7 cells. And the hairpin siRNA against green fluorescence protein (GFP) was used as the negative control. The suppressant efficiency of the LRP16 gene expression was confirmed by Nothern blot. Cell proliferation assay and soft agar colony formation assay were used to determine the status of the cells proliferation. Cell cycle checkpoints including cyclin E and cyclin D1 were examined by Western blot. Results: The results from cell proliferation assays suggested that down-regulation of LRP16 gene expression is capable of inhibiting MCF-7 breast cancer cell growth and down-regulation of the LRP16 gene expression is able to inhibit anchorage-independent growth of breast cancer cells in soft agar. We also demonstrated that cyclin E and cyclin D1 proteins were much lower in the LRP16-inhibitory cells than in the control cells. Conclusion: These data suggest that LRP16 gene play an important role in MCF-7 cells proliferation by regulating the pathway of the G1/S transition and may function as an important modulator in regulating the process of tumorigenesis in human breast.

  2. Small RNAs targeting transcription start site induce heparanase silencing through interference with transcription initiation in human cancer cells.

    Directory of Open Access Journals (Sweden)

    Guosong Jiang

    Full Text Available Heparanase (HPA, an endo-h-D-glucuronidase that cleaves the heparan sulfate chain of heparan sulfate proteoglycans, is overexpressed in majority of human cancers. Recent evidence suggests that small interfering RNA (siRNA induces transcriptional gene silencing (TGS in human cells. In this study, transfection of siRNA against -9/+10 bp (siH3, but not -174/-155 bp (siH1 or -134/-115 bp (siH2 region relative to transcription start site (TSS locating at 101 bp upstream of the translation start site, resulted in TGS of heparanase in human prostate cancer, bladder cancer, and gastric cancer cells in a sequence-specific manner. Methylation-specific PCR and bisulfite sequencing revealed no DNA methylation of CpG islands within heparanase promoter in siH3-transfected cells. The TGS of heparanase did not involve changes of epigenetic markers histone H3 lysine 9 dimethylation (H3K9me2, histone H3 lysine 27 trimethylation (H3K27me3 or active chromatin marker acetylated histone H3 (AcH3. The regulation of alternative splicing was not involved in siH3-mediated TGS. Instead, siH3 interfered with transcription initiation via decreasing the binding of both RNA polymerase II and transcription factor II B (TFIIB, but not the binding of transcription factors Sp1 or early growth response 1, on the heparanase promoter. Moreover, Argonaute 1 and Argonaute 2 facilitated the decreased binding of RNA polymerase II and TFIIB on heparanase promoter, and were necessary in siH3-induced TGS of heparanase. Stable transfection of the short hairpin RNA construct targeting heparanase TSS (-9/+10 bp into cancer cells, resulted in decreased proliferation, invasion, metastasis and angiogenesis of cancer cells in vitro and in athymic mice models. These results suggest that small RNAs targeting TSS can induce TGS of heparanase via interference with transcription initiation, and significantly suppress the tumor growth, invasion, metastasis and angiogenesis of cancer cells.

  3. Small regulatory RNAs of the RNA interference (RNAi) pathway as a prophylactic treatment against fish pathogenic viruses

    DEFF Research Database (Denmark)

    Schyth, Brian Dall; Hajiabadi, Seyed Amir Hossein Jalali; Kristensen, Lasse Bøgelund Juel;

    2011-01-01

    . The mechanism can be programmed with several types of small double stranded RNAs - the type of which defines the destiny of the target. One such class of regulatory RNAs called microRNAs are upregulated due to various physiological responses of the cell and they suppress many genes simultaneously believed...

  4. Silencing of MGMT with small interference RNA reversed resistance in human BCUN-resistant glioma cell lines

    Institute of Scientific and Technical Information of China (English)

    XIE Si-ming; FANG Mao; GUO Hui; ZHONG Xue-yun

    2011-01-01

    Background Our previous study had cloned two glioma cell lines SWOZ1 and SWOZ2 isolated from parental glioma cell line SWO38.The 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) resistance of SWOZ1 was higher than that of SWOZ2.Since O6-methylguanine-DNA methyltransferase (MGMT) was thought to be closely related to BCNU resistance in glioma,this study aimed to explore the function of MGMT in glioma resistant to BCNU.Methods A BCNU resistant glioma cell line SWOZ2-BCNU was established.The expression of MGMT was detected in SWOZ1,SWOZ2 and SWOZ2-BCNU.Small interferencing RNA targeting MGMT was used to silence the expression of MGMT in resistant cell lines SWOZ1 and SWOZ2-BCNU.The cytotoxicity of BCNU to these cells was measured using the cell counting kit-8 assay.Statistical analysis was carried out by one-way analysis of variance in statistical package SPSS 13.0.Results The resistance of SWOZ1 and SWOZ2-BCNU against BCNU was 4.9-fold and 5.3-fold higher than that of SWOZ2.The results of quantitative RT-PCR and Western blotting confirmed that MGMT was both significantly increased in SWOZ1 and SWOZ2-BCNU compared to SOWZ2.After transfection with small interferencing RNA targeting MGMT,a decreased level of MGMT mRNA expression in SWOZ1 and SWOZ2-BCNU for more than 75% compared to negative control was found and confirmed by Western blotting.As a result,the resistance against BCNU was reversed for about 50% both in the BCNU-resistant cell lines SWOZ1 and SWOZ2-BCNU.Conclusions Silencing MGMT with specific small interferencing RNA can reverse the BCNU resistant phenotype in these glioma cell lines.MGMT may play an important role both in intrinsic and acquired BCNU-resistance in glioma.

  5. Identification of a Small Molecular Anti - HIV - 1 Compound that Interferes with Formation of the Fusion - active gp41 Core

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    The human immunodeficiency virus type 1 (HIV - 1 ) envelope glycoprotein gp41 plays a critical role in the fusion of viral and target cell membranes. The gp41 extracellular domain, which contains fusion peptide (FP), N - and C - terminal hydrophobic heptad repeats (NHR and CHR, respectively). Peptides derived from NHR and CHR regions,designated N- and C- peptides, respectively, can interact with each other to form a six - stranded coiled - coil domain, representing the fusion-active gp41 core. Our previous studies demonstrated that the C- peptides have potent inhibitory activity against HIV- 1 infection.These peptides inhibit HIV- 1 -mediated membrane fusion by binding to NHR regions for preventing the formation of fusion- active gp41 core. One of the C - peptides, T - 20, which is in the phase Ⅲ clinical trails, is expected to become the first peptide HIV fusion inhibitory drug in the near future. However, this peptide HIV fusion inhibitor lacks oral availability and is sensitive to the proteolytic digestion.Therefore, it is essential to develop small molecular non -peptide HIV fusion inhibitors having similar mechanism of action as the C- peptides. We have established an ELISA- based screening assay using a unique monoclonal antibody, NC- 1, which can specifically bind to a conformational epitope on the gp41 core domain. Using this screening assay, we have identified a small molecular anti- HIV- 1 compound,named ADS-Jl, which inhibits HIV- 1- mediated membrane fusion by blocking the interaction between the NHR and CHR regions to form the fusion - active gp41 core. This compound will be used as a lead to design and develop novel HIV fusion inhibitors as new drugs for the treatment of HIV infection and/or AIDS.

  6. Recovery of dynamic interference

    CERN Document Server

    Baghery, Mehrdad; Rost, Jan M

    2016-01-01

    We develop general quantitative criteria for dynamic interference, a manifestation of double-slit interference in time which should be realizable with brilliant state-of-the-art high-frequency laser sources. Our analysis reveals that the observation of dynamic interference hinges upon maximizing the difference between the dynamic polarization of the initial bound and the final continuum state of the electron during the light pulse, while keeping depletion of the initial state small. Confirmed by numerical results, we predict that this is impossible for the hydrogen ground-state but feasible with excited states explicitly exemplified with the hydrogen 2p-state.

  7. Small RNA interference-mediated gene silencing of heparanase abolishes the invasion, metastasis and angiogenesis of gastric cancer cells

    Directory of Open Access Journals (Sweden)

    Hou Xiaohua

    2010-02-01

    Full Text Available Abstract Background Heparanase facilitates the invasion and metastasis of cancer cells, and is over-expressed in many kinds of malignancies. Our studies indicated that heparanase was frequently expressed in advanced gastric cancers. The aim of this study is to determine whether silencing of heparanase expression can abolish the malignant characteristics of gastric cancer cells. Methods Three heparanase-specific small interfering RNA (siRNAs were designed, synthesized, and transfected into cultured gastric cancer cell line SGC-7901. Heparanase expression was measured by RT-PCR, real-time quantitative PCR and Western blot. Cell proliferation was detected by MTT colorimetry and colony formation assay. The in vitro invasion and metastasis of cancer cells were measured by cell adhesion assay, scratch assay and matrigel invasion assay. The angiogenesis capabilities of cancer cells were measured by tube formation of endothelial cells. Results Transfection of siRNA against 1496-1514 bp of encoding regions resulted in reduced expression of heparanase, which started at 24 hrs and lasted for 120 hrs post-transfection. The siRNA-mediated silencing of heparanase suppressed the cellular proliferation of SGC-7901 cells. In addition, the in vitro invasion and metastasis of cancer cells were attenuated after knock-down of heparanase. Moreover, transfection of heparanase-specific siRNA attenuated the in vitro angiogenesis of cancer cells in a dose-dependent manner. Conclusions These results demonstrated that gene silencing of heparanase can efficiently abolish the proliferation, invasion, metastasis and angiogenesis of human gastric cancer cells in vitro, suggesting that heparanase-specific siRNA is of potential values as a novel therapeutic agent for human gastric cancer.

  8. Caenorhabditis elegans RIG-I Homolog Mediates Antiviral RNA Interference Downstream of Dicer-Dependent Biogenesis of Viral Small Interfering RNAs

    Science.gov (United States)

    Coffman, Stephanie R.; Lu, Jinfeng; Guo, Xunyang; Zhong, Jing; Broitman-Maduro, Gina; Li, Wan-Xiang; Lu, Rui; Maduro, Morris

    2017-01-01

    ABSTRACT Dicer enzymes process virus-specific double-stranded RNA (dsRNA) into small interfering RNAs (siRNAs) to initiate specific antiviral defense by related RNA interference (RNAi) pathways in plants, insects, nematodes, and mammals. Antiviral RNAi in Caenorhabditis elegans requires Dicer-related helicase 1 (DRH-1), not found in plants and insects but highly homologous to mammalian retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs), intracellular viral RNA sensors that trigger innate immunity against RNA virus infection. However, it remains unclear if DRH-1 acts analogously to initiate antiviral RNAi in C. elegans. Here, we performed a forward genetic screen to characterize antiviral RNAi in C. elegans. Using a mapping-by-sequencing strategy, we uncovered four loss-of-function alleles of drh-1, three of which caused mutations in the helicase and C-terminal domains conserved in RLRs. Deep sequencing of small RNAs revealed an abundant population of Dicer-dependent virus-derived small interfering RNAs (vsiRNAs) in drh-1 single and double mutant animals after infection with Orsay virus, a positive-strand RNA virus. These findings provide further genetic evidence for the antiviral function of DRH-1 and illustrate that DRH-1 is not essential for the sensing and Dicer-mediated processing of the viral dsRNA replicative intermediates. Interestingly, vsiRNAs produced by drh-1 mutants were mapped overwhelmingly to the terminal regions of the viral genomic RNAs, in contrast to random distribution of vsiRNA hot spots when DRH-1 is functional. As RIG-I translocates on long dsRNA and DRH-1 exists in a complex with Dicer, we propose that DRH-1 facilitates the biogenesis of vsiRNAs in nematodes by catalyzing translocation of the Dicer complex on the viral long dsRNA precursors. PMID:28325765

  9. Silencing of hpv16 e6 and e7 oncogenic activities by small interference rna induces autophagy and apoptosis in human cervical cancer cells

    Directory of Open Access Journals (Sweden)

    Jonathan Salazar-León

    2011-08-01

    Full Text Available Cervical cancer is the second most common form of death by cancer in women worldwide and has special attention for the development of new treatment strategies. Human Papilloma Virus (HPV persistent infection is the main etiological agent of this neoplasia, and the main cellular transformation mechanism is by disruption of p53 and pRb function by interaction with HPV E6 and E7 oncoproteins. This generates alterations in cellular differentiation and cellular death inhibition. Thus, HPV E6 and E7 oncogenes represent suitable targets for the development of gene therapy strategies against cervical cancer. An attractive technology platform is developing for post-transcriptional selective silencing of gene expression, using small interference RNA. Therefore, in the present study, we used SiHa cells (HPV16+ transiently transfected with specific siRNA expression plasmids for HPV16 E6 and E7 oncogenes. In this model we detected repression of E6 and E7 oncogene and oncoprotein expression, an increase in p53 and hypophosphorylated pRb isoform protein expression, and autophagy and apoptosis morphology features. These findings suggest that selective silencing of HPV16 E6 and E7 oncogenes by siRNAs, has significant biological effects on the survival of human cancer cells and is a potential gene therapy strategy against cervical cancer.

  10. Toponymic interferences

    Directory of Open Access Journals (Sweden)

    Marius Ilie Oros

    1985-12-01

    Full Text Available The study of linguistic interferences has been greatly extended lately. It comprises all language sections. In onomastics great attention was paid to to the study of macrotoponyms of foreign origin. I would like to mention in this respect the research concerning the toponyms of Slavic origin in Romania and Greece, the toponyms of Romance origin in Yugoslavia etc. The studies referring to the interferences in microtoponymy are more rare. These call for the collecting of all microtoponyms through inquiries made in plaees inhabited by mixed populetion from the ethnic point of view. The microtoponymy of these places off ers a very interesting material as far as the interactiong the reciprocal in.fluences of two or more toponymic systems is concerned.

  11. Targeting the epidermal growth factor receptor in non-small cell lung cancer cells: the effect of combining RNA interference with tyrosine kinase inhibitors or cetuximab

    Directory of Open Access Journals (Sweden)

    Chen Gang

    2012-03-01

    Full Text Available Abstract Background The epidermal growth factor receptor (EGFR is a validated therapeutic target in non-small cell lung cancer (NSCLC. However, current single agent receptor targeting does not achieve a maximal therapeutic effect, and some mutations confer resistance to current available agents. In the current study we have examined, in different NSCLC cell lines, the combined effect of RNA interference targeting the EGFR mRNA, and inactivation of EGFR signaling using different receptor tyrosine kinase inhibitors (TKIs or a monoclonal antibody cetuximab. Methods NSCLC cells (cell lines HCC827, H292, H358, H1650, and H1975 were transfected with EGFR siRNA and/or treated with the TKIs gefitinib, erlotinib, and afatinib, and/or with the monoclonal antibody cetuximab. The reduction of EGFR mRNA expression was measured by real-time quantitative RT-PCR. The down-regulation of EGFR protein expression was measured by western blot, and the proliferation, viability, caspase3/7 activity, and apoptotic morphology were monitored by spectrophotometry, fluorimetry, and fluorescence microscopy. The combined effect of EGFR siRNA and different drugs was evaluated using a combination index. Results EGFR-specific siRNA strongly inhibited EGFR protein expression almost equally in all cell lines and inhibited cell growth and induced cell apoptosis in all NSCLC cell lines studied, albeit with a different magnitude. The effects on growth obtained with siRNA was strikingly different from the effects obtained with TKIs. The effects of siRNA probably correlate with the overall oncogenic significance of the receptor, which is only partly inhibited by the TKIs. The cells which showed weak response to TKIs, such as the H1975 cell line containing the T790M resistance mutation, were found to be responsive to siRNA knockdown of EGFR, as were cell lines with downstream TKI resistance mutations. The cell line HCC827, harboring an exon 19 deletion mutation, was more than 10-fold

  12. Extreme ultraviolet Talbot interference lithography.

    Science.gov (United States)

    Li, Wei; Marconi, Mario C

    2015-10-05

    Periodic nanopatterns can be generated using lithography based on the Talbot effect or optical interference. However, these techniques have restrictions that limit their performance. High resolution Talbot lithography is limited by the very small depth of focus and the demanding requirements in the fabrication of the master mask. Interference lithography, with large DOF and high resolution, is limited to simple periodic patterns. This paper describes a hybrid extreme ultraviolet lithography approach that combines Talbot lithography and interference lithography to render an interference pattern with a lattice determined by a Talbot image. As a result, the method enables filling the arbitrary shaped cells produced by the Talbot image with interference patterns. Detailed modeling, system design and experimental results using a tabletop EUV laser are presented.

  13. Interference Coordination for Dense Wireless Networks

    DEFF Research Database (Denmark)

    Soret, Beatriz; Pedersen, Klaus I.; Jørgensen, Niels T.K.

    2015-01-01

    The promise of ubiquitous and super-fast connectivity for the upcoming years will be in large part fulfilled by the addition of base stations and spectral aggregation. The resulting very dense networks (DenseNets) will face a number of technical challenges. Among others, the interference emerges ...... simply react to an identified interference problem. As an example, we propose two algorithms to apply time domain and frequency domain small cell interference coordination in a DenseNet....

  14. IETS and quantum interference

    DEFF Research Database (Denmark)

    Jørgensen, Jacob Lykkebo; Gagliardi, Alessio; Pecchia, Alessandro

    2014-01-01

    Destructive quantum interference in single molecule electronics is an intriguing phenomenon; however, distinguishing quantum interference effects from generically low transmission is not trivial. In this paper, we discuss how quantum interference effects in the transmission lead to either low...... suppressed when quantum interference effects dominate. That is, we expand the understanding of propensity rules in inelastic electron tunneling spectroscopy to molecules with destructive quantum interference....

  15. Pharmacological and small interference RNA-mediated inhibition of breast cancer-associated fatty acid synthase (oncogenic antigen-519) synergistically enhances Taxol (paclitaxel)-induced cytotoxicity.

    Science.gov (United States)

    Menendez, Javier A; Vellon, Luciano; Colomer, Ramon; Lupu, Ruth

    2005-05-20

    combined treatment of C75 and Taxol inactivated the anti-apoptotic AKT (protein kinase B) kinase more than either agent alone, as evidenced by a synergistic down-regulation of AKT phosphorylation at its activating site Ser(473) without affecting AKT protein levels. To rule out a role for non-FAS C75-mediated effects, we finally used the potent and highly sequence-specific mechanism of RNA interference (RNAi) to block FAS-dependent signaling. Importantly, SK-Br3 and multi-drug resistant MCF-7/AdrR cells transiently transfected with sequence-specific double-stranded RNA oligonucleotides targeting FAS gene demonstrated hypersensitivity to Taxol-induced apoptotic cell death. Our findings establish for the first time that FAS blockade augments the cytotoxicity of anti-mitotic drug Taxol against breast cancer cells and that this chemosensitizing effect is schedule-dependent. We suggest that the alternate activation of both the pro-apoptotic p38 MAPK-p53 signaling and the cytoprotective MEK1/2 --> ERK1/2 cascade, as well as the inactivation of the anti-apoptotic AKT activity may explain, at least in part, the sequence-dependent enhancement of Taxol-induced cytotoxicity and apoptosis that follows inhibition of FAS activity in breast cancer cells. If chemically stable FAS inhibitors demonstrate systemic anticancer effects of FAS inhibition in vivo, these findings may render FAS as a valuable molecular target to enhance the efficacy of taxanes-based chemotherapy in human breast cancer.

  16. Opportunistic Interference Alignment in MIMO Interference Channels

    CERN Document Server

    Perlaza, Samir Medina; Lasaulce, Samson; Chaufray, Jean Marie

    2008-01-01

    We present two interference alignment techniques such that an opportunistic point-to-point multiple input multiple output (MIMO) link can reuse, without generating any additional interference, the same frequency band of a similar pre-existing primary link. In this scenario, we exploit the fact that under power constraints, although each radio maximizes independently its rate by water-filling on their channel transfer matrix singular values, frequently, not all of them are used. Therefore, by aligning the interference of the opportunistic radio it is possible to transmit at a significant rate while insuring zero-interference on the pre-existing link. We propose a linear pre-coder for a perfect interference alignment and a power allocation scheme which maximizes the individual data rate of the secondary link. Our numerical results show that significant data rates are achieved even for a reduced number of antennas.

  17. Graphene quantum interference photodetector.

    Science.gov (United States)

    Alam, Mahbub; Voss, Paul L

    2015-01-01

    In this work, a graphene quantum interference (QI) photodetector was simulated in two regimes of operation. The structure consists of a graphene nanoribbon, Mach-Zehnder interferometer (MZI), which exhibits a strongly resonant transmission of electrons of specific energies. In the first regime of operation (that of a linear photodetector), low intensity light couples two resonant energy levels, resulting in scattering and differential transmission of current with an external quantum efficiency of up to 5.2%. In the second regime of operation, full current switching is caused by the phase decoherence of the current due to a strong photon flux in one or both of the interferometer arms in the same MZI structure. Graphene QI photodetectors have several distinct advantages: they are of very small size, they do not require p- and n-doped regions, and they exhibit a high external quantum efficiency.

  18. Graphene quantum interference photodetector

    Directory of Open Access Journals (Sweden)

    Mahbub Alam

    2015-03-01

    Full Text Available In this work, a graphene quantum interference (QI photodetector was simulated in two regimes of operation. The structure consists of a graphene nanoribbon, Mach–Zehnder interferometer (MZI, which exhibits a strongly resonant transmission of electrons of specific energies. In the first regime of operation (that of a linear photodetector, low intensity light couples two resonant energy levels, resulting in scattering and differential transmission of current with an external quantum efficiency of up to 5.2%. In the second regime of operation, full current switching is caused by the phase decoherence of the current due to a strong photon flux in one or both of the interferometer arms in the same MZI structure. Graphene QI photodetectors have several distinct advantages: they are of very small size, they do not require p- and n-doped regions, and they exhibit a high external quantum efficiency.

  19. RNA interference as a gene knockdown technique.

    Science.gov (United States)

    Shan, Ge

    2010-08-01

    Not many scientific breakthroughs bring significant advances simultaneously in both basic research and translational applications like the discovery of RNA interference. Along with the elucidation of the RNA interference pathway and the discovery of its participation in crucial biological events, a branch of science has grown to utilize the RNA interference pathway as a biotechnology for both basic and applied research. Small interference RNA, plasmid-, and virus-encoded short-hairpin RNA are now regular reagents in the tool box of biologists to knockdown the expression of specific genes posttranscriptionally. Efforts have also been made to develop RNA interference based therapeutics into reality. Many concerns about the RNA interference technique have now been answered through research and development, although hurdles are still present. In this review, the RNA interference/microRNA pathway is briefly introduced followed with a detailed summary about the design and application of the RNA interference experiments, along with examples of the utilization of the RNA interference technology in animal cells and model organisms. Recent progresses and current concerns are also highlighted. Two techniques, namely morpholino and external guide sequence, are discussed as complementary gene knockdown technology. RNA interference technology, along with several other alternative gene knockdown techniques, is now indispensable to modern biological and medical research.

  20. Small molecule inhibition of Epstein-Barr virus nuclear antigen-1 DNA binding activity interferes with replication and persistence of the viral genome.

    Science.gov (United States)

    Lee, Eun Kyung; Kim, Sun Young; Noh, Ka-Won; Joo, Eun Hye; Zhao, Bo; Kieff, Elliott; Kang, Myung-Soo

    2014-04-01

    The replication and persistence of extra chromosomal Epstein-Barr virus (EBV) episome in latently infected cells are primarily dependent on the binding of EBV-encoded nuclear antigen 1 (EBNA1) to the cognate EBV oriP element. In continuation of the previous study, herein we characterized EBNA1 small molecule inhibitors (H20, H31) and their underlying inhibitory mechanisms. In silico docking analyses predicted that H20 fits into a pocket in the EBNA1 DNA binding domain (DBD). However, H20 did not significantly affect EBNA1 binding to its cognate sequence. A limited structure-relationship study of H20 identified a hydrophobic compound H31, as an EBNA1 inhibitor. An in vitro EBNA1 EMSA and in vivo EGFP-EBNA1 confocal microscopy analysis showed that H31 inhibited EBNA1-dependent oriP sequence-specific DNA binding activity, but not sequence-nonspecific chromosomal association. Consistent with this, H31 repressed the EBNA1-dependent transcription, replication, and persistence of an EBV oriP plasmid. Furthermore, H31 induced progressive loss of EBV episome. In addition, H31 selectively retarded the growth of EBV-infected LCL or Burkitt's lymphoma cells. These data indicate that H31 inhibition of EBNA1-dependent DNA binding decreases transcription from and persistence of EBV episome in EBV-infected cells. These new compounds might be useful probes for dissecting EBNA1 functions in vitro and in vivo.

  1. Small interference RNA profiling reveals the essential role of human membrane trafficking genes in mediating the infectious entry of dengue virus

    Directory of Open Access Journals (Sweden)

    Chu Justin

    2010-02-01

    Full Text Available Abstract Background Dengue virus (DENV is the causative agent of Dengue fever and the life-threatening Dengue Haemorrhagic fever or Dengue shock syndrome. In the absence of anti-viral agents or vaccine, there is an urgent need to develop an effective anti-viral strategy against this medically important viral pathogen. The initial interplay between DENV and the host cells may represent one of the potential anti-viral targeting sites. Currently the involvements of human membrane trafficking host genes or factors that mediate the infectious cellular entry of dengue virus are not well defined. Results In this study, we have used a targeted small interfering RNA (siRNA library to identify and profile key cellular genes involved in processes of endocytosis, cytoskeletal dynamics and endosome trafficking that are important and essential for DENV infection. The infectious entry of DENV into Huh7 cells was shown to be potently inhibited by siRNAs targeting genes associated with clathrin-mediated endocytosis. The important role of clathrin-mediated endocytosis was confirmed by the expression of well-characterized dominant-negative mutants of genes in this pathway and by using the clathrin endocytosis inhibitor chlorpromazine. Furthermore, DENV infection was shown to be sensitive to the disruption of human genes in regulating the early to late endosomal trafficking as well as the endosomal acidic pH. The importance and involvement of both actin and microtubule dynamics in mediating the infectious entry of DENV was also revealed in this study. Conclusions Together, the findings from this study have provided a detail profiling of the human membrane trafficking cellular genes and the mechanistic insight into the interplay of these host genes with DENV to initiate an infection, hence broadening our understanding on the entry pathway of this medically important viral pathogen. These data may also provide a new potential avenue for development of anti

  2. Inter-WBAN Coexistence and Interference Mitigation

    Institute of Scientific and Technical Information of China (English)

    Bin Liu; Xiaosong Zhao; Lei Zou; Chang Wen Chen

    2015-01-01

    With promising applications in e⁃health and entertainment, wireless body area networks (WBANs) have attracted the in⁃terest of both academia and industry. If WBANs are densely deployed within a small area, serious problems may arise be⁃tween the WBANs. In this paper, we discuss issues related to the coexistence of WBANs and investigate the main fac⁃tors that cause inter⁃WBAN interference. We survey inter⁃WBAN interference mitigation strategies and track recent re⁃search developments. We also discuss unresolved issues re⁃lated to inter⁃WBAN interference mitigation and propose fu⁃ture research directions.

  3. Spin Interference in Rashba 2DEG Systems

    Science.gov (United States)

    Nitta, Junsaku

    The gate controllable SOI provides useful information about spin interference.1 Spin interference effects are studied in two different interference loop structures. It is known that sample specific conductance fluctuations affect the conductance in the interference loop. By using array of many interference loops, we carefully pick up TRS Altshuler-Aronov-Spivak (AAS)-type oscillation which is not sample specific and depends on the spin phase. The experimentally obtained gate voltage dependence of AAS oscillations indicates that the spin precession angle can be controlled by the gate voltage.2 We demonstrate the time reversal Aharonov-Casher (AC) effect in small arrays of mesoscopic rings.3 By using an electrostatic gate we can control the spin precession angle rate and follow the AC phase over several interference periods. We also see the second harmonic of the AC interference, oscillating with half the period. The spin interference is still visible after more than 20π precession angle. We have proposed a Stern-Gerlach type spin filter based on the Rashba SOI.4 A spatial gradient of effective magnetic field due to the nonuniform SOI separates spin up and down electrons. This spin filter works even without any external magnetic fields and ferromagnetic contacts. We show the semiconductor/ferromagnet hybrid structure is an effective way to detect magnetization process of submicron magnets. The problem of the spin injection from ferromagnetic contact into 2DEG is also disicussed. Note from Publisher: This article contains the abstract only.

  4. Conducted interference, challenges and interference cases

    NARCIS (Netherlands)

    Leferink, Frank Bernardus Johannes

    2015-01-01

    Conducted interference has become increasingly problematic in the past few years, especially within the 2-150 kHz band. The high penetration of non-linear loads, combined with distributed generation, will influence the voltage profile, i.e. the power quality. New technologies will introduce new type

  5. Conducted interference, challenges and interference cases

    NARCIS (Netherlands)

    Leferink, Frank Bernardus Johannes

    2015-01-01

    Conducted interference has become increasingly problematic in the past few years, especially within the 2-150 kHz band. The high penetration of non-linear loads, combined with distributed generation, will influence the voltage profile, i.e. the power quality. New technologies will introduce new

  6. Dark Matter Interference

    DEFF Research Database (Denmark)

    Del Nobile, Eugenio; Kouvaris, Christoforos; Sannino, Francesco

    2012-01-01

    We study different patterns of interference in WIMP-nuclei elastic scattering that can accommodate the DAMA and CoGeNT experiments via an isospin violating ratio $f_n/f_p=-0.71$. We study interference between the following pairs of mediators: Z and Z', Z' and Higgs, and two Higgs fields. We show ...

  7. How does interference fall?

    CERN Document Server

    Orlando, Patrick J; Modi, Kavan

    2016-01-01

    We study how single- and double-slit interference patterns fall in the presence of gravity. First, we demonstrate that universality of free fall still holds in this case, i.e., interference patterns fall just like classical objects. Next, we explore lowest order relativistic effects in the Newtonian regime by employing a recent quantum formalism which treats mass as an operator. This leads to interactions between non-degenerate internal degrees of freedom (like spin in an external magnetic field) and external degrees of freedom (like position). Based on these effects, we present an unusual phenomenon, in which a falling double slit interference pattern periodically decoheres and recoheres. The oscillations in the visibility of this interference occur due to correlations built up between spin and position. Finally, we connect the interference visibility revivals with non-Markovian quantum dynamics.

  8. Antitumor effect of RNA interference on non-small-cell lung cancer in vivo%RNA干扰技术抗非小细胞肺癌作用的体内实验研究

    Institute of Scientific and Technical Information of China (English)

    Min Zhang; Chunxue Bai; Xin Zhang; Ling Mao; Yuehong Wang

    2009-01-01

    Objective: Lung cancer has emerged as a leading cause of cancer death in the world. Current therapies are ineffective, thus new approaches are needed to improve the therapeutic ratio. RNA interference (RNAi) has shown promise in gene silencing in vitro, the potential of which in developing new methods for the therapy of non-small-cell lung cancer (NSCLC) needs to be further tested in vivo. In this study, chemically synthesized double-stranded RNA (dsRNA) targeting epidermal growth factor receptor (EGFR) was transfected into NSCLC cell line SPC-A1 cells and established the tumor bur-dened athymic nude mice model to investigate whether dsRNA could induce gene silencing in NSCLC cells in vivo. Methods:SPC-A1 was transfected with EGFR sequence-specific dsRNA formulated with Lipofectamine 2000. SPC-A1 cells (1 x 107>/mL) in 200 μL were injected s.c. Into the left flank area of the mice to establish the tumor burdened athymic nude mice model.Calculate the tumor growth inhibition rate by measuring the diameter and the weight of the tumor. Immunohistochemistry and Western blot were used to monitor the reduction in the production of the EGFR protein. Realtime RT-PCR was used to detect the silencing of the EGFR mRNA level. Results: It displayed that EGFR sequence specific dsRNA (dsRNA-EGFR)significantly inhibited the tumor growth in vivo. The tumor growth inhibition rate was 75.03%. The dsRNA-EGFR sequence specifically silenced EGFR with 53.6% of down-regulation of EGFR protein production and 32.3% of silencing of EGFR mRNA level. Conclusion: DsRNA-EGFR showed a blockbuster effect in downregulation of EGFR mRNA level and protein produc-tion, and inhibition of tumor growth in vivo.

  9. Group Based Interference Alignment

    CERN Document Server

    Ma, Yanjun; Chen, Rui; Yao, Junliang

    2010-01-01

    in $K$-user single-input single-output (SISO) frequency selective fading interference channels, it is shown that the achievable multiplexing gain is almost surely $K/2$ by using interference alignment (IA). However when the signaling dimensions is limited, allocating all the resource to all the users simultaneously is not optimal. According to this problem, a group based interference alignment (GIA) scheme is proposed and a search algorithm is designed to get the group patterns and the resource allocation among them. Analysis results show that our proposed scheme achieves a higher multiplexing gain when the resource is limited.

  10. CRISPR interference: a structural perspective

    Science.gov (United States)

    Reeks, Judith; Naismith, James H.; White, Malcolm F.

    2013-01-01

    CRISPR (cluster of regularly interspaced palindromic repeats) is a prokaryotic adaptive defence system, providing immunity against mobile genetic elements such as viruses. Genomically encoded crRNA (CRISPR RNA) is used by Cas (CRISPR-associated) proteins to target and subsequently degrade nucleic acids of invading entities in a sequence-dependent manner. The process is known as ‘interference’. In the present review we cover recent progress on the structural biology of the CRISPR/Cas system, focusing on the Cas proteins and complexes that catalyse crRNA biogenesis and interference. Structural studies have helped in the elucidation of key mechanisms, including the recognition and cleavage of crRNA by the Cas6 and Cas5 proteins, where remarkable diversity at the level of both substrate recognition and catalysis has become apparent. The RNA-binding RAMP (repeat-associated mysterious protein) domain is present in the Cas5, Cas6, Cas7 and Cmr3 protein families and RAMP-like domains are found in Cas2 and Cas10. Structural analysis has also revealed an evolutionary link between the small subunits of the type I and type III-B interference complexes. Future studies of the interference complexes and their constituent components will transform our understanding of the system. PMID:23805973

  11. Interference and Polarized Light.

    Science.gov (United States)

    Charas, Seymour

    1988-01-01

    Discusses a demonstration of interference phenomena using three sheets of polaroid material, a light source, and a light meter. Describes instructional procedures with mathematical expressions and a diagram. (YP)

  12. Interference in wireless ad hoc networks with smart antennas

    KAUST Repository

    Alabdulmohsin, Ibrahim

    2014-08-01

    In this paper, we show that the use of directional antennas in wireless ad hoc networks can actually increase interference due to limitations of virtual carrier sensing. We derive a simple mathematical expression for interference in both physical and virtual carrier sense networks, which reveals counter-intuitively that receivers in large dense networks with directional antennas can experience larger interference than in omnidirectional networks unless the beamwidth is sufficiently small. Validity of mathematical analysis is confirmed using simulations.

  13. Understanding ghost interference

    Science.gov (United States)

    Qureshi, Tabish; Chingangbam, Pravabati; Shafaq, Sheeba

    2016-08-01

    The ghost interference observed for entangled photons is theoretically analyzed using wave-packet dynamics. It is shown that ghost interference is a combined effect of virtual double-slit creation due to entanglement, and quantum erasure of which-path information for the interfering photon. For the case where the two photons are of different color, it is shown that fringe width of the interfering photon depends not only on its own wavelength, but also on the wavelength of the other photon which it is entangled with.

  14. Retroactive Interference and Forgetting

    Directory of Open Access Journals (Sweden)

    Vinishaa Ankala

    2011-01-01

    Full Text Available Retroactive interference is the amount of information that can be forgotten by a person over time due to newly learned material. In this paper we establish a relationship between the amount of information forgotten by college students while they read and watch television and the time taken to forget it. We equate these numerical equations to solve for the unknown constants. By doing so, we can find the exact equation and also the amount of forgetting information due to retroactive interference.

  15. DNA-guided DNA interference by a prokaryotic Argonaute

    NARCIS (Netherlands)

    Swarts, D.C.; Jore, M.M.; Westra, E.R.; Zhu, Y.; Janssen, J.H.; Snijders, A.P.; Wang, Y.; Patel, D.J.; Berenguer, J.; Brouns, S.J.J.; Oost, van der J.

    2014-01-01

    RNA interference is widely distributed in eukaryotes and has a variety of functions, including antiviral defence and gene regulation. All RNA interference pathways use small single-stranded RNA (ssRNA) molecules that guide proteins of the Argonaute (Ago) family to complementary ssRNA targets:

  16. Destructive Interference of Dualities

    CERN Document Server

    Wotzasek, C

    1998-01-01

    We show that the fusion of two (diffeomorphism) invariant self-dual scalars described by right and left chiral-WZW actions, produces a Hull non-mover field. After fusion, right and left moving modes disappear from the spectrum, displaying in this way the phenomenon of (destructive) quantum interference of dualities.

  17. Interference Alignment for Secrecy

    CERN Document Server

    Koyluoglu, Onur Ozan; Lai, Lifeng; Poor, H Vincent

    2008-01-01

    This paper studies the frequency/time selective $K$-user Gaussian interference channel with secrecy constraints. Two distinct models, namely the interference channel with confidential messages and the one with an external eavesdropper, are analyzed. The key difference between the two models is the lack of channel state information (CSI) about the external eavesdropper. Using interference alignment along with secrecy pre-coding, it is shown that each user can achieve non-zero secure Degrees of Freedom (DoF) for both cases. More precisely, the proposed coding scheme achieves $\\frac{K-2}{2K-2}$ secure DoF {\\em with probability one} per user in the confidential messages model. For the external eavesdropper scenario, on the other hand, it is shown that each user can achieve $\\frac{K-2}{2K}$ secure DoF {\\em in the ergodic setting}. Remarkably, these results establish the {\\em positive impact} of interference on the secrecy capacity region of wireless networks.

  18. Quantum interference in polyenes

    Science.gov (United States)

    Tsuji, Yuta; Hoffmann, Roald; Movassagh, Ramis; Datta, Supriyo

    2014-12-01

    The explicit form of the zeroth Green's function in the Hückel model, approximated by the negative of the inverse of the Hückel matrix, has direct quantum interference consequences for molecular conductance. We derive a set of rules for transmission between two electrodes attached to a polyene, when the molecule is extended by an even number of carbons at either end (transmission unchanged) or by an odd number of carbons at both ends (transmission turned on or annihilated). These prescriptions for the occurrence of quantum interference lead to an unexpected consequence for switches which realize such extension through electrocyclic reactions: for some specific attachment modes the chemically closed ring will be the ON position of the switch. Normally the signs of the entries of the Green's function matrix are assumed to have no physical significance; however, we show that the signs may have observable consequences. In particular, in the case of multiple probe attachments - if coherence in probe connections can be arranged - in some cases new destructive interference results, while in others one may have constructive interference. One such case may already exist in the literature.

  19. Quantum interference in polyenes

    Energy Technology Data Exchange (ETDEWEB)

    Tsuji, Yuta; Hoffmann, Roald, E-mail: rh34@cornell.edu [Department of Chemistry and Chemical Biology, Cornell University, Baker Laboratory, Ithaca, New York 14853 (United States); Movassagh, Ramis [Department of Mathematics, Northeastern University, Boston, Massachusetts 02115, USA and Department of Mathematics, Massachusetts Institute of Technology, Building E18, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139-4307 (United States); Datta, Supriyo [School of Electrical and Computer Engineering, Purdue University, Electrical Engineering Building, 465 Northwestern Ave., West Lafayette, Indiana 47907-2035 (United States)

    2014-12-14

    The explicit form of the zeroth Green's function in the Hückel model, approximated by the negative of the inverse of the Hückel matrix, has direct quantum interference consequences for molecular conductance. We derive a set of rules for transmission between two electrodes attached to a polyene, when the molecule is extended by an even number of carbons at either end (transmission unchanged) or by an odd number of carbons at both ends (transmission turned on or annihilated). These prescriptions for the occurrence of quantum interference lead to an unexpected consequence for switches which realize such extension through electrocyclic reactions: for some specific attachment modes the chemically closed ring will be the ON position of the switch. Normally the signs of the entries of the Green's function matrix are assumed to have no physical significance; however, we show that the signs may have observable consequences. In particular, in the case of multiple probe attachments – if coherence in probe connections can be arranged – in some cases new destructive interference results, while in others one may have constructive interference. One such case may already exist in the literature.

  20. Laser Interference Lithography

    NARCIS (Netherlands)

    van Wolferen, Hendricus A.G.M.; Abelmann, Leon; Hennessy, Theodore C.

    In this chapter we explain how submicron gratings can be prepared by Laser Interference Lithography (LIL). In this maskless lithography technique, the standing wave pattern that exists at the intersection of two coherent laser beams is used to expose a photosensitive layer. We show how to build the

  1. Downlink Interference Alignment

    CERN Document Server

    Suh, Changho; Tse, David

    2010-01-01

    We develop an interference alignment (IA) technique for a downlink cellular system. In the uplink, IA schemes need channel-state-information exchange across base-stations of different cells, but our downlink IA technique requires feedback only within a cell. As a result, the proposed scheme can be implemented with a few changes to an existing cellular system where the feedback mechanism (within a cell) is already being considered for supporting multi-user MIMO. Not only is our proposed scheme implementable with little effort, it can in fact provide substantial gain especially when interference from a dominant interferer (base-station) is significantly stronger than the remaining interference: it is shown that in the two-isolated cell layout, our scheme provides four-fold gain in throughput performance over a standard multi-user MIMO technique. We show through simulations that our technique provides respectable gain under more realistic scenarios: it gives approximately 55% and 20% gain for a linear cell layou...

  2. Interference and radioastronomy

    Science.gov (United States)

    Thompson, A. R.; Vanden Bout, Paul A.; Gergely, Tomas E.

    1991-11-01

    The vulnerabilty of radio astronomy to the growing flood of interfering sources ranging from garage door openers to digital audio broadcast satellites is reviewed. Technical solutions to these problems are briefly examined, and work that needs to be done in the international regulatory system to ameliorate the interference is addressed. An overview is given of existing regulations.

  3. Interference Decoding for Deterministic Channels

    CERN Document Server

    Bandemer, Bernd

    2010-01-01

    An inner bound to the capacity region of a class of three user pair deterministic interference channels is presented. The key idea is to simultaneously decode the combined interference signal and the intended message at each receiver. It is shown that this interference decoding inner bound is strictly larger than the inner bound obtained by treating interference as noise, which includes interference alignment for deterministic channels. The gain comes from judicious analysis of the number of combined interference sequences in different regimes of input distributions and message rates.

  4. RNA interference and antiviral therapy

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    RNA interference (RNAi) is an evolutionally conserved gene silencing mechanism present in a variety of eukaryotic species. RNAi uses short double-stranded RNA (dsRNA) to trigger degradation or translation repression of homologous RNA targets in a sequence-specific manner. This system can be induced effectively in vitro and in vivo by direct application of small interfering RNAs (siRNAs), or by expression of short hairpin RNA (shRNA) with non-viral and viral vectors. To date, RNAi has been extensively used as a novel and effective tool for functional genomic studies, and has displayed great potential in treating human diseases, including human genetic and acquired disorders such as cancer and viral infections. In the present review, we focus on the recent development in the use of RNAi in the prevention and treatment of viral infections. The mechanisms,strategies, hurdles and prospects of employing RNAi in the pharmaceutical industry are also discussed.

  5. Abstract Certification of Global Non-Interference in Rewriting Logic

    CERN Document Server

    Alba-Castro, Mauricio; Escobar, Santiago

    2010-01-01

    Non-interference is a semantic program property that assigns confidentiality levels to data objects and prevents illicit information flows from occurring from high to low security levels. In this paper, we present a novel security model for global non-interference which approximates non-interference as a safety property. We also propose a certification technique for global non-interference of complete Java classes based on rewriting logic, a very general logical and semantic framework that is efficiently implemented in the high-level programming language Maude. Starting from an existing Java semantics specification written in Maude, we develop an extended, information-flow Java semantics that allows us to correctly observe global non-interference policies. In order to achieve a finite state transition system, we develop an abstract Java semantics that we use for secure and effective non-interference Java analysis. The analysis produces certificates that are independently checkable and are small enough to be u...

  6. Transmission of Correlated Messages over Interference Channels with Strong Interference

    Science.gov (United States)

    Choi, Suhan; Yoon, Eunchul; Moon, Hichan

    Transmission of correlated messages over interference channels with strong interference is considered. As a result, an achievable rate region is presented. It is shown that if the messages are correlated, the achievable rate region can be larger than the capacity region given by Costa and El Gamal. As an example, the Gaussian interference channel is considered.

  7. Electromagnetic interference: a radiant future!

    NARCIS (Netherlands)

    Leferink, Frank Bernardus Johannes

    2015-01-01

    Although Electromagnetic Interference and Electromagnetic Compatibility are well established domains, the introduction of new technologies results in new challenges. Changes in both measurement techniques, and technological trends resulting in new types of interference are described. These are the S

  8. Electromagnetic interference: a radiant future!

    NARCIS (Netherlands)

    Leferink, Frank Bernardus Johannes

    2015-01-01

    Although Electromagnetic Interference and Electromagnetic Compatibility are well established domains, the introduction of new technologies results in new challenges. Changes in both measurement techniques, and technological trends resulting in new types of interference are described. These are the

  9. Holographic interference filters

    Science.gov (United States)

    Diehl, Damon W.

    Holographic mirrors have wavelength-selection properties and thus qualify as a class of interference filters. Two theoretical methods for analyzing such structures are developed. The first method uses Hill's matrix method to yield closed-forms solutions in terms of the Floquet-Bloch waves within a periodic structure. A process is developed for implementing this solution method on a computer, using sparse-matrix memory allocation, numerical root-finding algorithms, and inverse-iteration techniques. It is demonstrated that Hill's matrix method is valid for the analysis of finite and multi-periodic problems. The second method of theoretical analysis is a transfer-matrix technique, which is herein termed thin-film decomposition. It is shown that the two methods of solution yield results that differ by, at worst, a fraction of a percent. Using both calculation techniques, a number of example problems are explored. Of key importance is the construction of a set of curves that are useful for the design and characterization of holographic interference filters. In addition to the theoretical development, methods are presented for the fabrication of holographic interference filters using DuPont HRF-800X001 photopolymer. Central to the exposure system is a frequency-stabilized, tunable dye laser. The types of filters fabricated include single-tone reflection filters, two types of multitone reflection filters, and reflection filters for infrared wavelengths. These filters feature index profiles that are not easily attainable through other fabrication methods. As a supplement to the body of the dissertation, the computer algorithms developed to implement Hill's matrix method and thin-film decomposition are also included as an appendix. Further appendices provide more information on Floquet's theorem and Hill's matrix method. A final appendix presents a design for an infrared laser spectrophotometer.

  10. Diboson Interference Resurrection arXiv

    CERN Document Server

    Panico, Giuliano; Wulzer, Andrea

    High-energy diboson processes at the LHC are potentially powerful indirect probes of heavy new physics, whose effects can be encapsulated in higher-dimensional operators or in modified Standard Model couplings. An obstruction however comes from the fact that leading new physics effects often emerge in diboson helicity amplitudes that are anomalously small in the Standard Model. As such, the formally leading Standard Model/New Physics interference contribution cancels in inclusive measurements. This paper describes a solution to this problem.

  11. Interference to satellite systems produced by rainscatter

    Science.gov (United States)

    Howell, R. G.; Thompson, P. T.

    1991-10-01

    Data, obtained from eight small dish receivers, placed around the United Kingdom, and designed to detect the scattering by rain of signals from the British Telecom (BT) 11 GHz microwave network, is presented. Fifteen site years of measurements were analyzed to produce cumulative distributions of effective receive antenna noise temperature and, where rainscattered signals were detected, cumulative distributions of transmission loss. The results obtained are compared with those predicted by a BT/University of Essex rainscatter interference prediction model (SCIMP).

  12. Partial Interference Alignment for K-user MIMO Interference Channels

    CERN Document Server

    Huang, Huang

    2011-01-01

    In this paper, we consider a Partial Interference Alignment and Interference Detection (PIAID) design for $K$-user quasi-static MIMO interference channels with discrete constellation inputs. Each transmitter has M antennas and transmits L independent data streams to the desired receiver with N receive antennas. We focus on the case where not all K-1 interfering transmitters can be aligned at every receiver. As a result, there will be residual interference at each receiver that cannot be aligned. Each receiver detects and cancels the residual interference based on the constellation map. However, there is a window of unfavorable interference profile at the receiver for Interference Detection (ID). In this paper, we propose a low complexity Partial Interference Alignment scheme in which we dynamically select the user set for IA so as to create a favorable interference profile for ID at each receiver. We first derive the average symbol error rate (SER) by taking into account of the non-Guassian residual interfere...

  13. Sensing via optical interference

    Directory of Open Access Journals (Sweden)

    Ryan C. Bailey

    2005-04-01

    Full Text Available Chemical and biological sensing are problems of tremendous contemporary technological importance in multiple regulatory and human health contexts, including environmental monitoring, water quality assurance, workplace air quality assessment, food quality control, many aspects of biodiagnostics, and, of course, homeland security. Frequently, what is needed, or at least wanted, are sensors that are simultaneously cheap, fast, reliable, selective, sensitive, robust, and easy to use. Unfortunately, these are often conflicting requirements. Over the past few years, however, a number of promising ideas based on optical interference effects have emerged. Each is based to some extent on advances in the design and fabrication of functional materials. Generally, the advances are of two kinds: chemo- and bio-selective recognition and binding, and efficient methods for micropatterning or microstructuring.

  14. RNA interference in Lepidoptera

    DEFF Research Database (Denmark)

    Terenius, Ole; Papanicolaou, Alexie; Garbutt, Jennie S.

    2011-01-01

    Gene silencing through RNA interference (RNAi) has revolutionized the study of gene function, particularly in non-model insects. However, in Lepidoptera (moths and butterflies) RNAi has many times proven to be difficult to achieve. Most of the negative results have been anecdotal and the positive...... is particularly successful in the family Saturniidae and in genes involved in immunity. On the contrary, gene expression in epidermal tissues seems to be most difficult to silence. In addition, gene silencing by feeding dsRNA requires high concentrations for success. Possible causes for the variability of success...... in RNAi experiments in Lepidoptera are discussed. The review also points to a need to further investigate the mechanism of RNAi in lepidopteran insects and its possible connection to the innate immune response. Our general understanding of RNAi in Lepidoptera will be further aided in the future as our...

  15. Quantum Interference in Graphene Nanoconstrictions.

    Science.gov (United States)

    Gehring, Pascal; Sadeghi, Hatef; Sangtarash, Sara; Lau, Chit Siong; Liu, Junjie; Ardavan, Arzhang; Warner, Jamie H; Lambert, Colin J; Briggs, G Andrew D; Mol, Jan A

    2016-07-13

    We report quantum interference effects in the electrical conductance of chemical vapor deposited graphene nanoconstrictions fabricated using feedback controlled electroburning. The observed multimode Fabry-Pérot interferences can be attributed to reflections at potential steps inside the channel. Sharp antiresonance features with a Fano line shape are observed. Theoretical modeling reveals that these Fano resonances are due to localized states inside the constriction, which couple to the delocalized states that also give rise to the Fabry-Pérot interference patterns. This study provides new insight into the interplay between two fundamental forms of quantum interference in graphene nanoconstrictions.

  16. RF Self-Interference cancellation for Full-Duplex

    NARCIS (Netherlands)

    van Liempd, B.; Debaillie, B.; Craninckx, J.; Lavin, C.; Palacios, C.; Malotaux, S.; Long, J.R.; van den Broek, Dirk-Jan; Klumperink, Eric A.M.

    2014-01-01

    This paper proposes two RF self-interference cancellation techniques. Their small form-factor enables full-duplex communication links for small-to-medium size portable devices and hence promotes the adoption of full-duplex in mass-market applications and next-generation standards, e.g. IEEE802.11 an

  17. Interference in motor learning - is motor interference sensory?

    DEFF Research Database (Denmark)

    Jensen, Jesper Lundbye; Petersen, Tue Hvass; Rothwell, John C

    mechanisms determine whether or not interference occurs. We hypothesised that interference requires the same neural circuits to be engaged in the two tasks and provoke competing processes of synaptic plasticity. To test this, subjects learned a ballistic ankle plantarflexion task. Early motor memory...

  18. Genomes of parasitic nematodes (Meloidogyne hapla, Meloidogyne incognita, Ascaris suum and Brugia malayi) have a reduced complement of small RNA interference pathway genes: knockdown can reduce host infectivity of M. incognita.

    Science.gov (United States)

    Iqbal, Sadia; Fosu-Nyarko, John; Jones, Michael G K

    2016-07-01

    The discovery of RNA interference (RNAi) as an endogenous mechanism of gene regulation in a range of eukaryotes has resulted in its extensive use as a tool for functional genomic studies. It is important to study the mechanisms which underlie this phenomenon in different organisms, and in particular to understand details of the effectors that modulate its effectiveness. The aim of this study was to identify and compare genomic sequences encoding genes involved in the RNAi pathway of four parasitic nematodes: the plant parasites Meloidogyne hapla and Meloidogyne incognita and the animal parasites Ascaris suum and Brugia malayi because full genomic sequences were available-in relation to those of the model nematode Caenorhabditis elegans. The data generated was then used to identify some potential targets for control of the root knot nematode, M. incognita. Of the 84 RNAi pathway genes of C. elegans used as model in this study, there was a 42-53 % reduction in the number of effectors in the parasitic nematodes indicating substantial differences in the pathway between species. A gene each from six functional groups of the RNAi pathway of M. incognita was downregulated using in vitro RNAi, and depending on the gene (drh-3, tsn-1, rrf-1, xrn-2, mut-2 and alg-1), subsequent plant infection was reduced by up to 44 % and knockdown of some genes (i.e. drh-3, mut-2) also resulted in abnormal nematode development. The information generated here will contribute to defining targets for more robust nematode control using the RNAi technology.

  19. Adaptive transmit selection with interference suppression

    KAUST Repository

    Radaydeh, Redha Mahmoud Mesleh

    2010-01-01

    This paper studies the performance of adaptive transmit channel selection in multipath fading channels. The adaptive selection algorithms are configured for single-antenna bandwidth-efficient or power-efficient transmission with as low transmit channel estimations as possible. Due to the fact that the number of active co-channel interfering signals and their corresponding powers experience random behavior, the adaptation to channels conditions, assuming uniform buffer and traffic loading, is proposed to be jointly based on the transmit channels instantaneous signal-to-noise ratios (SNRs) and signal-to- interference-plus- noise ratios (SINRs). Two interference cancelation algorithms, which are the dominant cancelation and the less complex arbitrary cancelation, are considered, for which the receive antenna array is assumed to have small angular spread. Analytical formulation for some performance measures in addition to several processing complexity and numerical comparisons between various adaptation schemes are presented. ©2010 IEEE.

  20. Canceling Interference in Acupuncture Points Signal

    Directory of Open Access Journals (Sweden)

    Yanexy San Martín Reyes

    2012-07-01

    Full Text Available The present paper propose the cancellation of interference or artifacts by the method of Allen in signals captured in different acupuncture points (Small Intestine Meridian, points ID1-ID2 and ID1-ID19. It is considered that the biosignal under study should be able to be characterized after its acquisition by subtracting the different interference variables that may coexist in the measurement zone, as it is in the case of ECG or any other artifact. The biosignal obtained as a result of the cancellation will be the acupuncture signal or from its imperfection another wave can be obtained as from a bioelectrical point of view such imperfection can be characterized and at the same time can bb useful to establish a long-term correspondence between the behavior of the signals on various acupuncture points and different diseases.

  1. Multiscale Investigation of Chemical Interference in Proteins

    CERN Document Server

    Samiotakis, Antonios; Cheung, Margaret S

    2010-01-01

    We developed a multiscale approach (MultiSCAAL) that integrates the potential of mean force (PMF) obtained from all-atomistic molecular dynamics simulations with a knowledge-based energy function for coarse-grained molecular simulations in better exploring the energy landscape of a small protein under chemical interference such as chemical denaturation. An excessive amount of water molecules in all-atomistic molecular dynamics simulations often negatively impacts the sampling efficiency of some advanced sampling techniques such as the replica exchange method and it makes the investigation of chemical interferences on protein dynamics difficult. Thus, there is a need to develop an effective strategy that focuses on sampling structural changes in protein conformations rather than solvent molecule fluctuations. In this work, we address this issue by devising a multiscale simulation scheme (MultiSCAAL) that bridges the gap between all-atomistic molecular dynamics simulation and coarse-grained molecular simulation...

  2. Sleep can reduce proactive interference.

    Science.gov (United States)

    Abel, Magdalena; Bäuml, Karl-Heinz T

    2014-01-01

    Sleep has repeatedly been connected to processes of memory consolidation. While extensive research indeed documents beneficial effects of sleep on memory, little is yet known about the role of sleep for interference effects in episodic memory. Although two prior studies reported sleep to reduce retroactive interference, no sleep effect has previously been found for proactive interference. Here we applied a study format differing from that employed by the prior studies to induce a high degree of proactive interference, and asked participants to encode a single list or two interfering lists of paired associates via pure study cycles. Testing occurred after 12 hours of diurnal wakefulness or nocturnal sleep. Consistent with the prior work, we found sleep in comparison to wake did not affect memory for the single list, but reduced retroactive interference. In addition we found sleep reduced proactive interference, and reduced retroactive and proactive interference to the same extent. The finding is consistent with the view that arising benefits of sleep are caused by the reactivation of memory contents during sleep, which has been suggested to strengthen and stabilise memories. Such stabilisation may make memories less susceptible to competition from interfering memories at test and thus reduce interference effects.

  3. Output Interference in Recognition Memory

    Science.gov (United States)

    Criss, Amy H.; Malmberg, Kenneth J.; Shiffrin, Richard M.

    2011-01-01

    Dennis and Humphreys (2001) proposed that interference in recognition memory arises solely from the prior contexts of the test word: Interference does not arise from memory traces of other words (from events prior to the study list or on the study list, and regardless of similarity to the test item). We evaluate this model using output…

  4. The RNA interference revolution

    Directory of Open Access Journals (Sweden)

    G. Lenz

    2005-12-01

    Full Text Available The discovery of double-stranded RNA-mediated gene silencing has rapidly led to its use as a method of choice for blocking a gene, and has turned it into one of the most discussed topics in cell biology. Although still in its infancy, the field of RNA interference has already produced a vast array of results, mainly in Caenorhabditis elegans, but recently also in mammalian systems. Micro-RNAs are short hairpins of RNA capable of blocking translation, which are transcribed from genomic DNA and are implicated in several aspects from development to cell signaling. The present review discusses the main methods used for gene silencing in cell culture and animal models, including the selection of target sequences, delivery methods and strategies for a successful silencing. Expected developments are briefly discussed, ranging from reverse genetics to therapeutics. Thus, the development of the new paradigm of RNA-mediated gene silencing has produced two important advances: knowledge of a basic cellular mechanism present in the majority of eukaryotic cells and access to a potent and specific new method for gene silencing.

  5. Communications in interference limited networks

    CERN Document Server

    2016-01-01

    This book offers means to handle interference as a central problem of operating wireless networks. It investigates centralized and decentralized methods to avoid and handle interference as well as approaches that resolve interference constructively. The latter type of approach tries to solve the joint detection and estimation problem of several data streams that share a common medium. In fact, an exciting insight into the operation of networks is that it may be beneficial, in terms of an overall throughput, to actively create and manage interference. Thus, when handled properly, "mixing" of data in networks becomes a useful tool of operation rather than the nuisance as which it has been treated traditionally. With the development of mobile, robust, ubiquitous, reliable and instantaneous communication being a driving and enabling factor of an information centric economy, the understanding, mitigation and exploitation of interference in networks must be seen as a centrally important task.

  6. Interference and Diffraction.

    Science.gov (United States)

    Ross, Marc H.

    This monograph was written for the Conference on the New Instructional Materials in Physics, held at the University of Washington in summer, 1965. The measurement of very small distances and sizes, and the concept of models are discussed in the introduction. The optics of slits is dealt with in chapter 2. Chapter 3 presents the optics of holes.…

  7. Optical interference with digital holograms

    Science.gov (United States)

    Gossman, David; Perez-Garcia, Benjamin; Hernandez-Aranda, Raul I.; Forbes, Andrew

    2016-07-01

    In 1804, Thomas Young reported the observation of fringes in the intensity of light, and attributed it to the concept of interference between coherent sources. In this paper, we revisit this famous experiment and show how it can easily be demonstrated with digital holography. We look closely at the concept of interference with light and ask, "fringes in what?" We then show that depending on how light interferes, fringe patterns in observables other than intensity can be seen. We explain this conceptually and demonstrate it experimentally. We provide a holistic approach to the topic, aided by modern laboratory practices for a straightforward demonstration of the underlying physics.

  8. Improving Dense Network Performance through Centralized Scheduling and Interference Coordination

    DEFF Research Database (Denmark)

    Lopez, Victor Fernandez; Pedersen, Klaus I.; Alvarez, Beatriz Soret

    2017-01-01

    . Interference management at the receiver is achieved through the use of a Network-Assisted Interference Cancellation and Suppression (NAICS) receiver. In order to further boost the 5th percentile user data rates, the transmission rank at the interferers is selectively reduced by a centralized rank coordination......Dense network deployments comprising small cells pose a series of important challenges when it comes to achieving an efficient resource use and curbing inter-cell interference in the downlink. This article examines different techniques to treat these problems in a dynamic way, from the network...... and the receiver sides. As a network coordination scheme, we apply a centralized joint cell association and scheduling mechanism based on dynamic cell switching, by which users are not always served by the strongest perceived cell. The method simultaneously resultsin more balanced loads and increased performance...

  9. Common Interferences in Drug Testing.

    Science.gov (United States)

    Smith, Michael P; Bluth, Martin H

    2016-12-01

    Interferences relating to laboratory toxicology testing refer to results which differ from their true value and are often encountered in the setting of a drug screen compared with confirmatory testing. Such interferences fall into two general categories; those that cause false positive results (when a drug screen is positive but confirmatory testing is negative) and those that cause false negative results (when a drug screen is negative when in reality the sample donor has ingested the tested substance). Such interferences can result from differences in laboratory testing methodology, reagent and analyte cross reactivity, limits of analyte detection, instrument resolution, reporting cutoff, sample processing, tissue type and sample adulteration among others. Awareness of the possible causes of such interferences are integral to proper laboratory result interpretation and patient management. Copyright © 2016 Elsevier Inc. All rights reserved.

  10. Interference Phenomena in Quantum Information

    CERN Document Server

    Stefanak, Martin

    2010-01-01

    One of the key features of quantum mechanics is the interference of probability amplitudes. The reason for the appearance of interference is mathematically very simple. It is the linear structure of the Hilbert space which is used for the description of quantum systems. In terms of physics we usually talk about the superposition principle valid for individual and composed quantum objects. So, while the source of interference is understandable it leads in fact to many counter-intuitive physical phenomena which puzzle physicists for almost hundred years. The present thesis studies interference in two seemingly disjoint fields of physics. However, both have strong links to quantum information processing and hence are related. In the first part we study the intriguing properties of quantum walks. In the second part we analyze a sophisticated application of wave packet dynamics in atoms and molecules for factorization of integers. The main body of the thesis is based on the original contributions listed separately...

  11. Interference of Quantum Market Strategies

    CERN Document Server

    Piotrowski, E W; Syska, J

    2003-01-01

    Recent development in quantum computation and quantum information theory allows to extend the scope of game theory for the quantum world. The paper is devoted to the analysis of interference of quantum strategies in quantum market games.

  12. Multipolar interference effects in nanophotonics

    CERN Document Server

    Liu, Wei

    2016-01-01

    Scattering of electromagnetic waves by an arbitrary nanoscale object can be characterized by a multipole decomposition of the electromagnetic field that allows to describe the scattering intensity and radiation pattern through interferences of dominating excited multipole modes. In modern nanophotonics, both generation and interference of multipole modes start to play an indispensable role, and they enable nanoscale manipulation of light with many related applications. Here we review the multipolar interference effects in metallic, metal-dielectric, and dielectric nanostructures, and suggest a comprehensive view on many phenomena involving the interferences of electric, magnetic and toroidal multipoles, which drive a number of recently discussed effects in nanophotonics such as unidirectional scattering, effective optical antiferromagnetism, generalized Kerker scattering with controlled angular patterns, generalized Brewster angle, and nonradiating optical anapoles. We further discuss other types of possible ...

  13. Evaluate interference in digital channels

    Science.gov (United States)

    Davarian, F.; Sumida, J.

    1985-01-01

    Any future mobile satellite service (MSS) which is to provide simultaneous mobile communications for a large number of users will have to make very efficient use of the spectrum. As the spectrum available for an MSS is limited, the system's channels should be packed as closely together as possible, with minimum-width guard bands. In addition the employment of frequency reuse schemes is an important factor. Difficulties regarding these solutions are related to the introduction of interference in the link. A balance must be achieved between the competing aims of spectrum conservation and low interference. While the interference phenomenon in narrowband FM voice channels is reasonably well understood, very little effort, however, has been devoted to the problem in digital radios. Attention is given to work, which illuminates the effects of cochannel and adjacent channel interference on digital FM (FSK) radios.

  14. CRISPR interference directs strand specific spacer acquisition.

    Directory of Open Access Journals (Sweden)

    Daan C Swarts

    Full Text Available BACKGROUND: CRISPR/Cas is a widespread adaptive immune system in prokaryotes. This system integrates short stretches of DNA derived from invading nucleic acids into genomic CRISPR loci, which function as memory of previously encountered invaders. In Escherichia coli, transcripts of these loci are cleaved into small RNAs and utilized by the Cascade complex to bind invader DNA, which is then likely degraded by Cas3 during CRISPR interference. RESULTS: We describe how a CRISPR-activated E. coli K12 is cured from a high copy number plasmid under non-selective conditions in a CRISPR-mediated way. Cured clones integrated at least one up to five anti-plasmid spacers in genomic CRISPR loci. New spacers are integrated directly downstream of the leader sequence. The spacers are non-randomly selected to target protospacers with an AAG protospacer adjacent motif, which is located directly upstream of the protospacer. A co-occurrence of PAM deviations and CRISPR repeat mutations was observed, indicating that one nucleotide from the PAM is incorporated as the last nucleotide of the repeat during integration of a new spacer. When multiple spacers were integrated in a single clone, all spacer targeted the same strand of the plasmid, implying that CRISPR interference caused by the first integrated spacer directs subsequent spacer acquisition events in a strand specific manner. CONCLUSIONS: The E. coli Type I-E CRISPR/Cas system provides resistance against bacteriophage infection, but also enables removal of residing plasmids. We established that there is a positive feedback loop between active spacers in a cluster--in our case the first acquired spacer--and spacers acquired thereafter, possibly through the use of specific DNA degradation products of the CRISPR interference machinery by the CRISPR adaptation machinery. This loop enables a rapid expansion of the spacer repertoire against an actively present DNA element that is already targeted, amplifying the

  15. Interference, reduced action, and trajectories

    OpenAIRE

    2006-01-01

    Instead of investigating the interference between two stationary, rectilinear wave functions in a trajectory representation by examining the two rectilinear wave functions individually, we examine a dichromatic wave function that is synthesized from the two interfering wave functions. The physics of interference is contained in the reduced action for the dichromatic wave function. As this reduced action is a generator of the motion for the dichromatic wave function, it determines the dichroma...

  16. Multipolar interference effects in nanophotonics.

    Science.gov (United States)

    Liu, Wei; Kivshar, Yuri S

    2017-03-28

    Scattering of electromagnetic waves by an arbitrary nanoscale object can be characterized by a multipole decomposition of the electromagnetic field that allows one to describe the scattering intensity and radiation pattern through interferences of dominating multipole modes excited. In modern nanophotonics, both generation and interference of multipole modes start to play an indispensable role, and they enable nanoscale manipulation of light with many related applications. Here, we review the multipolar interference effects in metallic, metal-dielectric and dielectric nanostructures, and suggest a comprehensive view on many phenomena involving the interferences of electric, magnetic and toroidal multipoles, which drive a number of recently discussed effects in nanophotonics such as unidirectional scattering, effective optical antiferromagnetism, generalized Kerker scattering with controlled angular patterns, generalized Brewster angle, and non-radiating optical anapoles. We further discuss other types of possible multipolar interference effects not yet exploited in the literature and envisage the prospect of achieving more flexible and advanced nanoscale control of light relying on the concepts of multipolar interference through full phase and amplitude engineering.This article is part of the themed issue 'New horizons for nanophotonics'.

  17. Inhibition of protein kinase CK2 with the clinical-grade small ATP-competitive compound CX-4945 or by RNA interference unveils its role in acute myeloid leukemia cell survival, p53-dependent apoptosis and daunorubicin-induced cytotoxicity.

    Science.gov (United States)

    Quotti Tubi, Laura; Gurrieri, Carmela; Brancalion, Alessandra; Bonaldi, Laura; Bertorelle, Roberta; Manni, Sabrina; Pavan, Laura; Lessi, Federica; Zambello, Renato; Trentin, Livio; Adami, Fausto; Ruzzene, Maria; Pinna, Lorenzo A; Semenzato, Gianpietro; Piazza, Francesco

    2013-10-12

    The involvement of protein kinase CK2 in sustaining cancer cell survival could have implications also in the resistance to conventional and unconventional therapies. Moreover, CK2 role in blood tumors is rapidly emerging and this kinase has been recognized as a potential therapeutic target. Phase I clinical trials with the oral small ATP-competitive CK2 inhibitor CX-4945 are currently ongoing in solid tumors and multiple myeloma. We have analyzed the expression of CK2 in acute myeloid leukemia and its function in cell growth and in the response to the chemotherapeutic agent daunorubicin We employed acute myeloid leukemia cell lines and primary blasts from patients grouped according to the European LeukemiaNet risk classification. Cell survival, apoptosis and sensitivity to daunorubicin were assessed by different means. p53-dependent CK2-inhibition-induced apoptosis was investigated in p53 wild-type and mutant cells. CK2a was found highly expressed in the majority of samples across the different acute myeloid leukemia prognostic subgroups as compared to normal CD34+ hematopoietic and bone marrow cells. Inhibition of CK2 with CX-4945, K27 or siRNAs caused a p53-dependent acute myeloid leukemia cell apoptosis. CK2 inhibition was associated with a synergistic increase of the cytotoxic effects of daunorubicin. Baseline and daunorubicin-induced STAT3 activation was hampered upon CK2 blockade. These results suggest that CK2 is over expressed across the different acute myeloid leukemia subsets and acts as an important regulator of acute myeloid leukemia cell survival. CK2 negative regulation of the protein levels of tumor suppressor p53 and activation of the STAT3 anti-apoptotic pathway might antagonize apoptosis and could be involved in acute myeloid leukemia cell resistance to daunorubicin.

  18. Demonstrations of Beats as Moving Interference Patterns.

    Science.gov (United States)

    Stein, T. S.; Dishman, L. G.

    1982-01-01

    Describes a ripple tank demonstration that displays interference patterns responsible for producing beats and provides photographs of computer simulations of various beat interference patterns. Includes programs for the computer simulation and equations of constructive interference paths in beat interference patterns. (Author/SK)

  19. Whirling waves in Interference experiments

    Science.gov (United States)

    Sinha, Urbasi; Sawant, Rahul; Samuel, Joseph; Sinha, Aninda; Sinha, Supurna

    2014-03-01

    In a double slit interference experiment, the wave function at the screen with both slits open is not exactly the sum of the wave functions with the slits individually open one at a time. The three scenarios represent three different boundary conditions and as such, the superposition principle should not be applicable. However, most well- known text books in quantum mechanics implicitly and/or explicitly use this assumption, the wave function hypothesis, which is only approximately true. In our present study, we have used the Feynman path integral formalism to quantify contributions from non-classical paths in interference experiments which provide a measurable deviation from the wave function hypothesis. A direct experimental demonstration for the existence of these non-classical paths is hard. We find that contributions from such paths can be significant and we propose simple three-slit interference experiments to directly confirm their existence. I will also describe some ongoing experimental efforts towards testing our theoretical findings.

  20. Transmission Techniques for Relay-Interference Networks

    CERN Document Server

    Mohajer, Soheil; Fragouli, Christina; Tse, David N C

    2008-01-01

    In this paper we study the relay-interference wireless network, in which relay (helper) nodes are to facilitate competing information flows over a wireless network. We examine this in the context of a deterministic wireless interaction model, which eliminates the channel noise and focuses on the signal interactions. Using this model, we show that almost all the known schemes such as interference suppression, interference alignment and interference separation are necessary for relay-interference networks. In addition, we discover a new interference management technique, which we call interference neutralization, which allows for over-the-air interference removal, without the transmitters having complete access the interfering signals. We show that interference separation, suppression, and neutralization arise in a fundamental manner, since we show complete characterizations for special configurations of the relay-interference network.

  1. Interference in ballistic motor learning - is motor interference really sensory?

    DEFF Research Database (Denmark)

    Lundbye-Jensen, Jesper; Petersen, Tue Hvass; Rothwell, John C

    learned a ballistic ankle plantarflexion task. Interference was observed following subsequent learning of a precision tracking task with the same movement direction and agonist muscles, but not by learning involving the opposite movement and antagonist muscles or by voluntary agonist contractions that did...

  2. Interference, Reduced Action, and Trajectories

    Science.gov (United States)

    Floyd, Edward R.

    2007-09-01

    Instead of investigating the interference between two stationary, rectilinear wave functions in a trajectory representation by examining the trajectories of the two rectilinear wave functions individually, we examine a dichromatic wave function that is synthesized from the two interfering wave functions. The physics of interference is contained in the reduced action for the dichromatic wave function. As this reduced action is a generator of the motion for the dichromatic wave function, it determines the dichromatic wave function’s trajectory. The quantum effective mass renders insight into the behavior of the trajectory. The trajectory in turn renders insight into quantum nonlocality.

  3. Interference, reduced action, and trajectories

    CERN Document Server

    Floyd, E R

    2006-01-01

    Instead of investigating the interference between two stationary, rectilinear wave functions in a trajectory representation by examining the two rectilinear wave functions individually, we examine a dichromatic wave function that is synthesized from the two interfering wave functions. The physics of interference is contained in the reduced action for the dichromatic wave function. As this reduced action is a generator of the motion for the dichromatic wave function, it determines the dichromatic wave function's trajectory. The quantum effective mass renders insight into the behavior of the trajectory. The trajectory in turn renders insight into quantum nonlocality.

  4. Interference of diffusive light waves.

    Science.gov (United States)

    Schmitt, J M; Knüttel, A; Knutson, J R

    1992-10-01

    We examine interference effects resulting from the superposition of photon-density waves produced by coherently modulated light incident upon a turbid medium. Photon-diffusion theory is used to derive expressions for the ac magnitude and phase of the aggregate diffusive wave produced in full- and half-space volumes by two sources. Using a frequency-domain spectrometer operating at 410 MHz, we verify interference patterns predicted by the model in scattering samples having optical properties similar to those of skin tissue. Potential imaging applications of interfering diffusive waves are discussed in the context of the theoretical and experimental results.

  5. "Quantum Interference with Slits" Revisited

    CERN Document Server

    Rothman, Tony

    2010-01-01

    Marcella [arXiv:quant-ph/0703126] has presented a straightforward technique employing the Dirac formalism to calculate single- and double-slit interference patterns. He claims that no reference is made to classical optics or scattering theory and that his method therefore provides a purely quantum mechanical description of these experiments. He also presents his calculation as if no approximations are employed. We show that he implicitly makes the same approximations found in classical treatments of interference and that no new physics has been introduced. At the same time, some of the quantum mechanical arguments Marcella gives are, at best, misleading.

  6. Interference in Time: A Comment

    CERN Document Server

    Horwitz, L P

    2005-01-01

    I comment on the interpretation of a recent experiment showing quantum interference in time. It is pointed out that the standard nonrelativistic quantum theory, used by the authors in their analysis, cannot account for the results found, and therefore that this experiment has fundamental importance beyond the technical advances it represents.

  7. "Quantum Interference with Slits" Revisited

    Science.gov (United States)

    Rothman, Tony; Boughn, Stephen

    2011-01-01

    Marcella has presented a straightforward technique employing the Dirac formalism to calculate single- and double-slit interference patterns. He claims that no reference is made to classical optics or scattering theory and that his method therefore provides a purely quantum mechanical description of these experiments. He also presents his…

  8. Political Interference in Climate Science

    Science.gov (United States)

    Kumar, Mohi

    2007-02-01

    ``All of us have a right to our own views about the seriousness of global warming,'' U.S. Rep. Henry Waxman (D-Calif.), chair of the House Oversight and Government Reform Committee, said at a 30 January committee hearing held to examine political interference in climate science. ``But we don't have a right to our own science.''

  9. "Quantum Interference with Slits" Revisited

    Science.gov (United States)

    Rothman, Tony; Boughn, Stephen

    2011-01-01

    Marcella has presented a straightforward technique employing the Dirac formalism to calculate single- and double-slit interference patterns. He claims that no reference is made to classical optics or scattering theory and that his method therefore provides a purely quantum mechanical description of these experiments. He also presents his…

  10. Interference and memory capacity limitations.

    Science.gov (United States)

    Endress, Ansgar D; Szabó, Szilárd

    2017-10-01

    Working memory (WM) is thought to have a fixed and limited capacity. However, the origins of these capacity limitations are debated, and generally attributed to active, attentional processes. Here, we show that the existence of interference among items in memory mathematically guarantees fixed and limited capacity limits under very general conditions, irrespective of any processing assumptions. Assuming that interference (a) increases with the number of interfering items and (b) brings memory performance to chance levels for large numbers of interfering items, capacity limits are a simple function of the relative influence of memorization and interference. In contrast, we show that time-based memory limitations do not lead to fixed memory capacity limitations that are independent of the timing properties of an experiment. We show that interference can mimic both slot-like and continuous resource-like memory limitations, suggesting that these types of memory performance might not be as different as commonly believed. We speculate that slot-like WM limitations might arise from crowding-like phenomena in memory when participants have to retrieve items. Further, based on earlier research on parallel attention and enumeration, we suggest that crowding-like phenomena might be a common reason for the 3 major cognitive capacity limitations. As suggested by Miller (1956) and Cowan (2001), these capacity limitations might arise because of a common reason, even though they likely rely on distinct processes. (PsycINFO Database Record (c) 2017 APA, all rights reserved).

  11. Investigation of spectral shifts in a white light interferometer with a single interference peak

    Science.gov (United States)

    Xu, Chunhui; Yi, Yingyan; Shu, Zhuo; Li, Min

    2015-04-01

    When the optical path difference between the two arms of an interferometer is so small that only one peak exists within the measurable interference spectrum, traditional white light interference demodulation techniques based on two adjacent interference peaks are not a suitable choice. We report an experimental approach to measure the peak wavelength shifts with only a single interference peak in a fiber white light interferometer. The temperature measurement experiments prove a linear relationship between the peak wavelength and the temperature. The temperature resolution is 0.1°C in theory.

  12. A generalized and parameterized interference model for cognitive radio networks

    KAUST Repository

    Mahmood, Nurul Huda

    2011-06-01

    For meaningful co-existence of cognitive radios with primary system, it is imperative that the cognitive radio system is aware of how much interference it generates at the primary receivers. This can be done through statistical modeling of the interference as perceived at the primary receivers. In this work, we propose a generalized model for the interference generated by a cognitive radio network, in the presence of small and large scale fading, at a primary receiver located at the origin. We then demonstrate how this model can be used to estimate the impact of cognitive radio transmission on the primary receiver in terms of different outage probabilities. Finally, our analytical findings are validated through some selected computer-based simulations. © 2011 IEEE.

  13. RNA interference: past, present and future.

    Science.gov (United States)

    Campbell, Tessa N; Choy, Francis Y M

    2005-01-01

    RNA interference (RNAi) is the sequence-specific gene silencing induced by double-stranded RNA. RNAi is mediated by 21-23 nucleotide small interfering RNAs (siRNAs) which are produced from long double-stranded RNAs by RNAse II-like enzyme Dicer. The resulting siRNAs are incorporated into a RNA-induced silencing complex (RISC) that targets and cleaves mRNA complementary to the siRNAs. Since its inception in 1998, RNAi has been demonstrated in organisms ranging from trypanosomes to nematodes to vertebrates. Potential uses already in progress include the examination of specific gene function in living systems, the development of anti-viral and anti-cancer therapies, and genome-wide screens. In this review, we discuss the landmark discoveries that established the contextual framework leading up to our current understanding of RNAi. We also provide an overview of current developments and future applications.

  14. Spatial DCT-Based Channel Estimation in Multi-Antenna Multi-Cell Interference Channels

    Science.gov (United States)

    Alodeh, Maha; Chatzinotas, Symeon; Ottersten, Bjorn

    2015-03-01

    This work addresses channel estimation in multiple antenna multicell interference-limited networks. Channel state information (CSI) acquisition is vital for interference mitigation. Wireless networks often suffer from multicell interference, which can be mitigated by deploying beamforming to spatially direct the transmissions. The accuracy of the estimated CSI plays an important role in designing accurate beamformers that can control the amount of interference created from simultaneous spatial transmissions to mobile users. Therefore, a new technique based on the structure of the spatial covariance matrix and the discrete cosine transform (DCT) is proposed to enhance channel estimation in the presence of interference. Bayesian estimation and Least Squares estimation frameworks are introduced by utilizing the DCT to separate the overlapping spatial paths that create the interference. The spatial domain is thus exploited to mitigate the contamination which is able to discriminate across interfering users. Gains over conventional channel estimation techniques are presented in our simulations which are also valid for a small number of antennas.

  15. RNA干扰抑制ERCC1对非小细胞肺癌化疗敏感性的影响%The effect of RNA interference-mediated ERCC1 gene on the chemo-treatment sensitivity of non-small-cell lung cancer

    Institute of Scientific and Technical Information of China (English)

    宋志雨; 周航

    2011-01-01

    目的 探讨利用RNA干扰技术沉默切除修复交叉互补基因组1(ERCC1)表达对非小细胞肺癌耐药细胞株顺铂化疗敏感性的影响.方法 设计并合成3段靶向人的ERCC1基因的小分子干扰RNA(siRNA),构建携带ERCC1-shRNA的重组质粒表达载体,采用脂质体Lipofectamine 2000转染入人肺癌细胞株A549/DDP,荧光镜下观察并测定转染效率;应用逆转录聚合酶链反应(RT-PCR)检测转染前后ERCC1 mRNA的表达情况;应用四甲基偶氮唑蓝比色法(MTT)检测干扰ERCC1后A549/DDP细胞对顺铂敏感性的变化.结果 转染针对ERCC1的siRNA后,转染组A549/DDP细胞内ERCC1 mRNA表达均下降,转染后肺癌A549/DDP细胞对顺铂敏感性增加.结论 利用RNA干扰技术能够筛选出高效的特异阻断ERCC1基因表达的siRNA;ERCC1基因表达下调能够增加肺癌A549/DDP细胞对顺铂的敏感性,部分逆转耐药.%Objective To investigate changes of platinum-based chemotherapy sensitivity of silencing excision repair cross complementation 1(ERCC1) gene expression by using RNA interference in non-small-cell lung cancer ( NSCLC) drug resistance cell lines. Methods Three siRNA sequences targeting ERCC1 gene were designed and synthesized. Recombinant plasmid expression vector which carrying ERCCl-shRNA was constructed and transfected into A54 9/DDP cells with Lipofectamine 2000. Transfection efficiency was measured in the fluorescent microscope. The expression of ERCC1 Mrna was detected by reverse transcription-poly-merase chain reaction(RT-PCR). The change of cisplatin sensitivity after interference was test by MTT assay. Results After transfection of ERCCl-siRNA,the ERCC1 Mrna expressions in A549/DDP cells were all reduced. The sensitivity to cisplatin of A549/ DDP cell line was increased after transfection. The sensitivity to cisplatin of A54 9/DDP cell line was increased after transfection. Conclusion Highly effective and specific siRNA targeting ERCC1 gene can be successfully

  16. REM sleep rescues learning from interference.

    Science.gov (United States)

    McDevitt, Elizabeth A; Duggan, Katherine A; Mednick, Sara C

    2015-07-01

    Classical human memory studies investigating the acquisition of temporally-linked events have found that the memories for two events will interfere with each other and cause forgetting (i.e., interference; Wixted, 2004). Importantly, sleep helps consolidate memories and protect them from subsequent interference (Ellenbogen, Hulbert, Stickgold, Dinges, & Thompson-Schill, 2006). We asked whether sleep can also repair memories that have already been damaged by interference. Using a perceptual learning paradigm, we induced interference either before or after a consolidation period. We varied brain states during consolidation by comparing active wake, quiet wake, and naps with either non-rapid eye movement sleep (NREM), or both NREM and REM sleep. When interference occurred after consolidation, sleep and wake both produced learning. However, interference prior to consolidation impaired memory, with retroactive interference showing more disruption than proactive interference. Sleep rescued learning damaged by interference. Critically, only naps that contained REM sleep were able to rescue learning that was highly disrupted by retroactive interference. Furthermore, the magnitude of rescued learning was correlated with the amount of REM sleep. We demonstrate the first evidence of a process by which the brain can rescue and consolidate memories damaged by interference, and that this process requires REM sleep. We explain these results within a theoretical model that considers how interference during encoding interacts with consolidation processes to predict which memories are retained or lost.

  17. Do media players cause interference with pacemakers?

    Science.gov (United States)

    Thaker, Jay P; Patel, Mehul B; Shah, Ashok J; Liepa, Valdis V; Brunett, Joseph D; Jongnarangsin, Krit; Gardiner, Joseph C; Thakur, Ranjan

    2009-11-01

    Electrical devices generate electromagnetic fields that may interfere with pacemakers. Media players cause telemetry interference with pacemakers, but it is not known whether they cause direct interference with pacemakers. The purpose of this study was to examine the interaction between pacemakers and 3 different media players. In this prospective, randomized study, 54 patients with dual chamber pacemakers who were in sinus rhythm underwent baseline observation, followed by observation under telemetry communication. These patients were then randomly evaluated with 3 media players (iPod 3G, iPod Photo, and iPod Touch Apple, Cupertino, CA) with and without telemetry communication for 1 minute each. Patients were monitored for pacemaker malfunction using a single-channel ECG during exposure to media players. The pacemaker was interrogated after each exposure and an interrogation report was printed for evaluation. Pacemaker interference was categorized as type I, II, or III. Types I and II interference described telemetry interference and type III interference was defined as any direct interference with pacemaker function or programmed parameters. A total of 54 patients (29 men and 25 women; mean age 77.2 +/- 9.3 y) were evaluated. In total, of the 162 tests (for telemetry interference) 36.4% were positive (Type I and II). Type III interference was also evaluated in 162 tests and none showed any evidence of direct interference. Media players cause telemetry interference with pacemakers, but they do not directly interfere with pacemaker function.

  18. Parasitic interference in nulling interferometry

    CERN Document Server

    Matter, Alexis; Danchi, William C; Lopez, Bruno; Absil, Olivier

    2013-01-01

    Nulling interferometry aims to detect faint objects close to bright stars. Its principle is to produce a destructive interference along the line-of-sight so that the stellar flux is rejected, while the flux of the off-axis source can be transmitted. In practice, various instrumental perturbations can degrade the nulling performance. Any imperfection in phase, amplitude, or polarization produces a spurious flux that leaks to the interferometer output and corrupts the transmitted off-axis flux. One of these instrumental pertubations is the crosstalk phenomenon, which occurs because of multiple parasitic reflections inside transmitting optics, and/or diffraction effects related to beam propagation along finite size optics. It can include a crosstalk of a beam with itself, and a mutual crosstalk between different beams. This can create a parasitic interference pattern, which degrades the intrinsic transmission map - or intensity response - of the interferometer. In this context, we describe how this instrumental ...

  19. Silicon superconducting quantum interference device

    Energy Technology Data Exchange (ETDEWEB)

    Duvauchelle, J. E.; Francheteau, A.; Marcenat, C.; Lefloch, F., E-mail: francois.lefloch@cea.fr [Université Grenoble Alpes, CEA - INAC - SPSMS, F-38000 Grenoble (France); Chiodi, F.; Débarre, D. [Université Paris-sud, CNRS - IEF, F-91405 Orsay - France (France); Hasselbach, K. [Université Grenoble Alpes, CNRS - Inst. Néel, F-38000 Grenoble (France); Kirtley, J. R. [Center for probing at nanoscale, Stanford University, Palo Alto, California 94305-4045 (United States)

    2015-08-17

    We have studied a Superconducting Quantum Interference Device (SQUID) made from a single layer thin film of superconducting silicon. The superconducting layer is obtained by heavily doping a silicon wafer with boron atoms using the gas immersion laser doping technique. The SQUID is composed of two nano-bridges (Dayem bridges) in a loop and shows magnetic flux modulation at low temperature and low magnetic field. The overall behavior shows very good agreement with numerical simulations based on the Ginzburg-Landau equations.

  20. Interference Mitigation in Cognitive Femtocells

    DEFF Research Database (Denmark)

    Da Costa, Gustavo Wagner Oliveira; Cattoni, Andrea Fabio; Alvarez Roig, Victor;

    2010-01-01

    in densely deployed femto scenarios. In this paper, two key elements of cognitive femtocells are combined: a power control algorithm and a fully distributed dynamic spectrum allocation method. The resulting solution was evaluated through system-level simulations and compared to the separate algorithms...... and fixed frequency reuses. The outage throughput performance of the combined algorithm exceeds all other options, proving the efficiency of the method in reducing inter-cell interference....

  1. RNA干扰%RNA Interference

    Institute of Scientific and Technical Information of China (English)

    陈颖; 朱明华

    2003-01-01

    RNA干扰(RNA interference,RNAi)是一种古老的生物抗病毒机制,能介导序列特异性的mRNA降解,是基因功能研究和蛋白组学的有效工具,在药物靶基因的筛选、抗病毒、肿瘤基因治疗等领域有很好的发展前景.

  2. Improved Linear Parallel Interference Cancellers

    CERN Document Server

    Srikanth, T; Chockalingam, A; Milstein, L B

    2007-01-01

    In this paper, taking the view that a linear parallel interference canceller (LPIC) can be seen as a linear matrix filter, we propose new linear matrix filters that can result in improved bit error performance compared to other LPICs in the literature. The motivation for the proposed filters arises from the possibility of avoiding the generation of certain interference and noise terms in a given stage that would have been present in a conventional LPIC (CLPIC). In the proposed filters, we achieve such avoidance of the generation of interference and noise terms in a given stage by simply making the diagonal elements of a certain matrix in that stage equal to zero. Hence, the proposed filters do not require additional complexity compared to the CLPIC, and they can allow achieving a certain error performance using fewer LPIC stages. We also extend the proposed matrix filter solutions to a multicarrier DS-CDMA system, where we consider two types of receivers. In one receiver (referred to as Type-I receiver), LPIC...

  3. 49 CFR 193.2633 - Interference currents.

    Science.gov (United States)

    2010-10-01

    ...: FEDERAL SAFETY STANDARDS Maintenance § 193.2633 Interference currents. (a) Each component that is subject to electrical current interference must be protected by a continuing program to minimize...

  4. Canceling Stationary Interference Signals Exploiting Secondary Data

    OpenAIRE

    Swärd, Johan; Jakobsson, Andreas

    2014-01-01

    In this paper, we propose a novel interference cancellation method that exploits secondary data to estimate stationary interference components present in both the primary and the secondary data sets, thereby allowing for the removal of such interference from the data sets, even when these components share frequencies with the signal of interest. The algorithm estimates the present interference components one frequency at a time, thus enabling for a computationally efficient algorithm, that re...

  5. Distributed Interference Alignment with Low Overhead

    CERN Document Server

    Ma, Yanjun; Chen, Rui

    2011-01-01

    Based on closed-form interference alignment (IA) solutions, a low overhead distributed interference alignment (LOIA) scheme is proposed in this paper for the $K$-user SISO interference channel, and extension to multiple antenna scenario is also considered. Compared with the iterative interference alignment (IIA) algorithm proposed by Gomadam et al., the overhead is greatly reduced. Simulation results show that the IIA algorithm is strictly suboptimal compared with our LOIA algorithm in the overhead-limited scenario.

  6. Convergent evolution of pathogenicity islands in helper cos phage interference

    Science.gov (United States)

    Manning, Keith A.; Dokland, Terje; Marina, Alberto

    2016-01-01

    Staphylococcus aureus pathogenicity islands (SaPIs) are phage satellites that exploit the life cycle of their helper phages for their own benefit. Most SaPIs are packaged by their helper phages using a headful (pac) packaging mechanism. These SaPIs interfere with pac phage reproduction through a variety of strategies, including the redirection of phage capsid assembly to form small capsids, a process that depends on the expression of the SaPI-encoded cpmA and cpmB genes. Another SaPI subfamily is induced and packaged by cos-type phages, and although these cos SaPIs also block the life cycle of their inducing phages, the basis for this mechanism of interference remains to be deciphered. Here we have identified and characterized one mechanism by which the SaPIs interfere with cos phage reproduction. This mechanism depends on a SaPI-encoded gene, ccm, which encodes a protein involved in the production of small isometric capsids, compared with the prolate helper phage capsids. As the Ccm and CpmAB proteins are completely unrelated in sequence, this strategy represents a fascinating example of convergent evolution. Moreover, this result also indicates that the production of SaPI-sized particles is a widespread strategy of phage interference conserved during SaPI evolution. This article is part of the themed issue ‘The new bacteriology’. PMID:27672154

  7. Convergent evolution of pathogenicity islands in helper cos phage interference.

    Science.gov (United States)

    Carpena, Nuria; Manning, Keith A; Dokland, Terje; Marina, Alberto; Penadés, José R

    2016-11-05

    Staphylococcus aureus pathogenicity islands (SaPIs) are phage satellites that exploit the life cycle of their helper phages for their own benefit. Most SaPIs are packaged by their helper phages using a headful (pac) packaging mechanism. These SaPIs interfere with pac phage reproduction through a variety of strategies, including the redirection of phage capsid assembly to form small capsids, a process that depends on the expression of the SaPI-encoded cpmA and cpmB genes. Another SaPI subfamily is induced and packaged by cos-type phages, and although these cos SaPIs also block the life cycle of their inducing phages, the basis for this mechanism of interference remains to be deciphered. Here we have identified and characterized one mechanism by which the SaPIs interfere with cos phage reproduction. This mechanism depends on a SaPI-encoded gene, ccm, which encodes a protein involved in the production of small isometric capsids, compared with the prolate helper phage capsids. As the Ccm and CpmAB proteins are completely unrelated in sequence, this strategy represents a fascinating example of convergent evolution. Moreover, this result also indicates that the production of SaPI-sized particles is a widespread strategy of phage interference conserved during SaPI evolution.This article is part of the themed issue 'The new bacteriology'.

  8. 47 CFR 22.353 - Blanketing interference.

    Science.gov (United States)

    2010-10-01

    ... are not required to resolve blanketing interference to mobile receivers or non-RF devices or... 47 Telecommunication 2 2010-10-01 2010-10-01 false Blanketing interference. 22.353 Section 22.353... Operational and Technical Requirements Technical Requirements § 22.353 Blanketing interference. Licensees of...

  9. An accumulator model of semantic interference

    NARCIS (Netherlands)

    van Maanen, Leendert; van Rijn, Hedderik

    2007-01-01

    To explain latency effects in picture-word interference tasks, cognitive models need to account for both interference and stimulus onset asynchrony (SOA) effects. As opposed to most models of picture-word interference, which model the time course during the task in a ballistic manner, the RACE model

  10. 表达端粒酶逆转录酶siRNA的溶瘤腺病毒对裸鼠肾癌移植瘤的治疗作用%The antitumor effects of oncolytic adenovirus armed with small interference RNA targeting hTERT gene for renal cancer therapy in nude mouse model

    Institute of Scientific and Technical Information of China (English)

    薛松; 刘斌; 高超; 顾玉明; 郑骏年; 李望; 李海龙; 朱海涛; 辛勇; 刘俊杰; 徐为; 宋文哲

    2009-01-01

    目的 观察表达针对端粒酶逆转录酶(hTERT)基因的小干扰RNA(hTERT siRNA)的溶瘤腺病毒(ZD55-hTERT)抑制肾癌移植瘤生长作用.方法 荷肾癌裸鼠随机分4组,每组8只.瘤体内分别注射ZD55-hTERT、增殖缺陷型腺病毒(Ad-hTERT)、溶瘤腺病毒ZD55-EGFP及磷酸盐缓冲液(PBS),每次注射病毒7×108pfu/只,连续注射3 d.注射后第7天,每组处死3只取肿瘤组织,免疫组织化学检测肿瘤hTERT、E1A表达及凋亡.第50天时处死动物测量肿瘤体积.结果 ZD55-hTERT、Ad-hTERT、ZD55-EGFP及PBS处理组肿瘤体积(mm3)分别为:124.1±27.5、609.0±102.5、499.8±77.1、1552.1±206.4,ZD55-hTERT处理组与各组之间差异有统计学意义(P<0.01).Ad-hTERT处理组肿瘤无E1A表达,ZD55-hTERT处理组E1A大量表达,表明病毒复制.ZD55-hTERT处理组肿瘤hTERT表达显著低于Ad-hTERT处理组,凋亡细胞阳性率均显著高于Ad-hTERT处理组.结论 表达hTERT siRNA的溶瘤腺病毒ZD55-hTERT具有更强的抑制肾癌生长作用.%Objective To investigate the antitumor effect of oncolytic adenovirus armed with small interference RNA targeting hTERT gene for renal cancer therapy. Methods Nude mice were divid-ed randomly into 4 groups (8 mice/group),and were treated by intratumoral injections of ZD55-hTERT ( an oncolytic adenovirus armed with small interference RNA targeting hTERT gene) ,ZD55-EGFP ( an on-colytic adenovirus) and Ad-hTERT (replication-defective adenovirus armed with small interference RNA targeting hTERT gene) with three consecutive daily at 7 × 108 pfu/day or treated with PBS as a control. The expression of E1A and hTERT, and apoptosis of tumor xenografts were assessed by immunohistochemi-cal technique at the 7th day after injections. The tumor volume was measured at the 50th day after injec-tions. Results The tumor volume in ZD55-hTERT treatment group ( 124.1±27.5) was significantly less than that in ZD-EGFP (499.8±77.1 ) and Ad-hTERT ( 609.0±102.5 ) treatment groups

  11. Codebook-based interference alignment for uplink MIMO interference channels

    KAUST Repository

    Lee, Hyun Ho

    2014-02-01

    In this paper, we propose a codebook-based interference alignment (IA) scheme in the constant multiple-input multipleoutput (MIMO) interference channel especially for the uplink scenario. In our proposed scheme, we assume cooperation among base stations (BSs) through reliable backhaul links so that global channel knowledge is available for all BSs, which enables BS to compute the transmit precoder and inform its quantized index to the associated user via limited rate feedback link.We present an upper bound on the rate loss of the proposed scheme and derive the scaling law of the feedback load tomaintain a constant rate loss relative to IA with perfect channel knowledge. Considering the impact of overhead due to training, cooperation, and feedback, we address the effective degrees of freedom (DOF) of the proposed scheme and derive the maximization of the effective DOF. From simulation results, we verify our analysis on the scaling law to preserve the multiplexing gain and confirm that the proposed scheme is more effective than the conventional IA scheme in terms of the effective DOF. © 2014 KICS.

  12. INTERFERENCE CANCELLATION FOR MOBILE DISPERSIVE CHANNELS

    Institute of Scientific and Technical Information of China (English)

    Kazi Takpaya

    2003-01-01

    A robust interference canceller for Multi-Carrier Code Division Multiple Access(MC-CDMA) using Orthogonal Frequency Division Multiplexing (OFDM) in Rayleigh fading isproposed. This interference canceller is robust in the sense that it cancels Inter-Carriers Inter-ference (ICI) and is suitable for use in dispersive channels. To come up the effects of the signaldispersion, Doppler shifts and delay spreads on the performance of MC-CDMA systems over mo-bile fading channels, this interference canceller exploits the merit of the orthogonal signaling andpilot signals to evaluate the channel parameters. This interface canceller is well suited to work initerative turbo interference cancellation.

  13. Iterative Equalization and Interference Alignment for Multiuser MIMO HetNets with Imperfect CSI

    Directory of Open Access Journals (Sweden)

    Daniel Castanheira

    2015-01-01

    Full Text Available In this paper we consider a scenario, where several small-cells work under the same coverage area and spectrum of a macrocell. The signals stemming from the small-cell (macrocell users if not carefully dealt with will generate harmful interference into the macrocell (small-cell. To tackle this problem interference alignment and iterative equalization techniques are considered. By using IA all interference generated by the small-cell (macrocell users is aligned along a low dimensional subspace, at the macrocell (small-cells. This reduces considerably the amount of resources allocated, to enable the coexistence of the two systems. However, perfect IA requires the availability of error-free channel state information (CSI at the transmitters. Due to CSI errors one can have substantial performance degradation due to imperfect alignments. Since in this work the IA precoders are based on imperfect CSI, an efficient iterative space-frequency equalization is designed at the receiver side to cope with the residual aligned interference. The results demonstrate that iterative equalization is robust to imperfect CSI and removes efficiently the interference generated by the poorly aligned interference. Close to matched filter bound performance is achieved, with a very few number of iterations.

  14. Embracing interference in wireless systems

    CERN Document Server

    Gollakota, Shyamnath

    2014-01-01

    The wireless medium is a shared resource. If nearby devices transmit at thesame time, their signals interfere, resulting in a collision. In traditionalnetworks, collisions cause the loss of the transmitted information. For thisreason, wireless networks have been designed with the assumption thatinterference is intrinsically harmful and must be avoided.This book, a revised version of the author's award-winning Ph.D.dissertation, takes an alternate approach: Instead of viewing interferenceas an inherently counterproductive phenomenon that should to be avoided, wedesign practical systems that tra

  15. Cooperative Feedback for MIMO Interference Channels

    CERN Document Server

    Huang, Kaibin

    2010-01-01

    Multi-antenna precoding effectively mitigates the interference in wireless networks. However, the precoding efficiency can be significantly degraded by the overhead due to the required feedback of channel state information (CSI). This paper addresses such an issue by proposing a systematic method of designing precoders for the two-user multiple-input-multiple-output (MIMO) interference channels based on finite-rate CSI feedback from receivers to their interferers, called cooperative feedback. Specifically, each precoder is decomposed into inner and outer precoders for nulling interference and improving the data link array gain, respectively. The inner precoders are further designed to suppress residual interference resulting from finite-rate cooperative feedback. To regulate residual interference due to precoder quantization, additional scalar cooperative feedback signals are designed to control transmitters' power using different criteria including applying interference margins, maximizing sum throughput, an...

  16. Assessment of life interference in anxious children

    DEFF Research Database (Denmark)

    Rapee, Ronald; Thastum, Mikael; Chavira, Denise

    life interference derived from symptoms of anxiety. Broader and more general life interference measures tend to have minimal relevance for children with anxiety disorders. The current paper will describe two measures of life interference that have been developed at the Centre for Emotional Health...... directed at children and adolescents. One measure, the Children's Anxiety Life Interference Scale (CALIS) was developed to assess interference directly associated with symptoms of anxiety in children and adolescents, while the other, the Adolescent Life Interference Scale (ALIS) is a broader measure....... This imbalance has particularly characterised research on child anxiety where few studies have examined either the impact of anxiety disorders on children's lives or the effects of treatments on life interference. To some extent this lack of attention has come from a lack of well developed measures to assess...

  17. Interference Mitigation in Large Random Wireless Networks

    CERN Document Server

    Aldridge, Matthew

    2011-01-01

    A central problem in the operation of large wireless networks is how to deal with interference -- the unwanted signals being sent by transmitters that a receiver is not interested in. This thesis looks at ways of combating such interference. In Chapters 1 and 2, we outline the necessary information and communication theory background, including the concept of capacity. We also include an overview of a new set of schemes for dealing with interference known as interference alignment, paying special attention to a channel-state-based strategy called ergodic interference alignment. In Chapter 3, we consider the operation of large regular and random networks by treating interference as background noise. We consider the local performance of a single node, and the global performance of a very large network. In Chapter 4, we use ergodic interference alignment to derive the asymptotic sum-capacity of large random dense networks. These networks are derived from a physical model of node placement where signal strength d...

  18. RNA interference and Register Machines (extended abstract

    Directory of Open Access Journals (Sweden)

    Masahiro Hamano

    2012-11-01

    Full Text Available RNA interference (RNAi is a mechanism whereby small RNAs (siRNAs directly control gene expression without assistance from proteins. This mechanism consists of interactions between RNAs and small RNAs both of which may be single or double stranded. The target of the mechanism is mRNA to be degraded or aberrated, while the initiator is double stranded RNA (dsRNA to be cleaved into siRNAs. Observing the digital nature of RNAi, we represent RNAi as a Minsky register machine such that (i The two registers hold single and double stranded RNAs respectively, and (ii Machine's instructions are interpreted by interactions of enzyme (Dicer, siRNA (with RISC com- plex and polymerization (RdRp to the appropriate registers. Interpreting RNAi as a computational structure, we can investigate the computational meaning of RNAi, especially its complexity. Initially, the machine is configured as a Chemical Ground Form (CGF, which generates incorrect jumps. To remedy this problem, the system is remodeled as recursive RNAi, in which siRNA targets not only mRNA but also the machine instructional analogues of Dicer and RISC. Finally, probabilistic termination is investigated in the recursive RNAi system.

  19. Investigation on a Small Oscillogram

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    A small oscillogram, one end of which was substituted by a bright point caused by the redox of an appropriate depolarizer and the other end of which was the redox of Hg or the redox of supporting electrolyte cation, was investigated in this paper. Experimental results of application of the small oscillogram to oscillographic determination of cefoperazone showed that the small oscillogram was more stable, sensitive, and less interference than classical oscillogram.

  20. Interference-free SDMA for FBMC-OQAM

    Science.gov (United States)

    Horlin, François; Fickers, Jessica; Deleu, Thibault; Louveaux, Jérome

    2013-12-01

    Filter-bank multi-carrier (FBMC) modulations have recently been considered for the emerging wireless communication systems as a means to improve the utilization of the physical resources and the robustness to channel time variations. FBMC divides the overall frequency channel in a set of subchannels of bandwidth proportionally decreasing with the number of subchannels. If the number of subchannels is high enough, the bandwidth of each subchannel is small enough to assume that it is approximately flat. On the other hand, space-division multiple access (SDMA) is a recognized technique to support multiple access in the downlink of a multi-user system. The user signals are precoded at the base station equipped with multiple antennas to separate the users in the spatial domain. The application of SDMA to FBMC is unfortunately difficult when the channel is too frequency selective (or when the number of subchannels to too small) to assume flat subchannels. In that case, the system suffers from inter-symbol and inter-subchannel interference, besides the multi-user interference inherent to SDMA. State-of-the art solutions simply neglect the inter-symbol/subchannel interference. This article proposes a new SDMA precoder for FBMC capable of mitigating the three sources of interference. It is constructed per subchannel in order to keep an acceptable complexity and has the structure of a filter applied on each subchannel and its neighbors at twice the symbol rate. Numerical results demonstrate that the precoder can get rid of all the interference present in the system and benefit therefore from the diversity and power gains achievable with multiple antenna systems.

  1. Modal interference in spiky nanoshells.

    Science.gov (United States)

    Hastings, Simon P; Qian, Zhaoxia; Swanglap, Pattanawit; Fang, Ying; Engheta, Nader; Park, So-Jung; Link, Stephan; Fakhraai, Zahra

    2015-05-04

    Near-field enhancement of the electric field by metallic nanostructures is important in non-linear optical applications such as surface enhanced Raman scattering. One approach to producing strong localization of the electric field is to couple a dark, non-radiating plasmonic mode with a broad dipolar resonator that is detectable in the far-field. However, characterizing or predicting the degree of the coupling between these modes for a complicated nanostructure can be quite challenging. Here we develop a robust method to solve the T-matrix, the matrix that predicts the scattered electric fields of the incident light, based on finite-difference time-domain (FDTD) simulations and least square fitting algorithms. This method allows us to simultaneously calculate the T-matrix for a broad spectral range. Using this method, the coupling between the electric dipole and quadrupole modes of spiky nanoshells is evaluated. It is shown that the built-in disorder in the structure of these nanoshells allows for coupling between the dipole modes of various orientations as well as coupling between the dipole and the quadrupole modes. A coupling strength of about 5% between these modes can explain the apparent interference features observed in the single particle scattering spectrum. This effect is experimentally verified by single particle backscattering measurements of spiky nanoshells. The modal interference in disordered spiky nanoshells can explain the origin of the spectrally broad quadrupole resonances that result in strong Quadrupole Enhanced Raman Scattering (QERS) in these nanoparticles.

  2. Motor interference in interactive contexts

    Directory of Open Access Journals (Sweden)

    Eris eChinellato

    2015-06-01

    Full Text Available Action observation and execution share overlapping neural substrates, so that simultaneous activation by observation and execution modulates motor performance. Previous literature on simple prehension tasks has revealed that motor influence can be two-sided: facilitation for observed and performed congruent actions and interference for incongruent actions. But little is known of the specific modulations of motor performance in complex forms of interaction. Is it possible that the very same observed movement can lead either to interference or facilitation effects on a temporally overlapping congruent executed action, depending on the context? To answer this question participants were asked to perform a reach-to-grasp movement adopting a precision grip (PG while: (i observing a fixation cross, (ii observing an actor performing a PG with interactive purposes, (iii observing an actor performing a PG without interactive purposes. In particular, in the interactive condition the actor was shown trying to pour some sugar on a large cup located out of her reach but close to the participant watching the video, thus eliciting in reaction a complementary whole-hand grasp. Notably, fine-grained kinematic analysis for this condition revealed a specific delay in the grasping and reaching components and an increased trajectory deviation despite the observed and executed movement’s congruency. Moreover, early peaks of trajectory deviation seem to indicate that socially relevant stimuli are acknowledged by the motor system very early. These data suggest that interactive contexts can determine a prompt modulation of stimulus–response compatibility effects.

  3. CRISPR interference: RNA-directed adaptive immunity in bacteria and archaea

    Science.gov (United States)

    Marraffini, Luciano A.; Sontheimer, Erik J.

    2010-01-01

    Sequence-directed genetic interference pathways control gene expression and preserve genome integrity in all kingdoms of life. The importance of such pathways is highlighted by the extensive study of RNA interference (RNAi) and related processes in eukaryotes. In many bacteria and most archaea, clustered, regularly interspaced short palindromic repeats (CRISPRs) are involved in a more recently discovered interference pathway that protects cells from bacteriophages and conjugative plasmids. CRISPR sequences provide an adaptive, heritable record of past infections and express CRISPR RNAs — small RNAs that target invasive nucleic acids. Here, we review the mechanisms of CRISPR interference and its roles in microbial physiology and evolution. We also discuss potential applications of this novel interference pathway. PMID:20125085

  4. Ramsey Interference with Single Photons

    Science.gov (United States)

    Clemmen, Stéphane; Farsi, Alessandro; Ramelow, Sven; Gaeta, Alexander L.

    2016-11-01

    Interferometry using discrete energy levels of nuclear, atomic, or molecular systems is the foundation for a wide range of physical phenomena and enables powerful techniques such as nuclear magnetic resonance, electron spin resonance, Ramsey-based spectroscopy, and laser or maser technology. It also plays a unique role in quantum information processing as qubits may be implemented as energy superposition states of simple quantum systems. Here, we demonstrate quantum interference involving energy states of single quanta of light. In full analogy to the energy levels of atoms or nuclear spins, we implement a Ramsey interferometer with single photons. We experimentally generate energy superposition states of a single photon and manipulate them with unitary transformations to realize arbitrary projective measurements. Our approach opens the path for frequency-encoded photonic qubits in quantum information processing and quantum communication.

  5. Multistage Relaying Using Interference Networks

    CERN Document Server

    Muthuramalingam, Bama; Thangaraj, Andrew

    2010-01-01

    Wireless networks with multiple nodes that relay information from a source to a destination are expected to be deployed in many applications. Therefore, understanding their design and performance under practical constraints is important. In this work, we propose and study three multihopping decode and forward (MDF) protocols for multistage half-duplex relay networks with no direct link between the source and destination nodes. In all three protocols, we assume no cooperation across relay nodes for encoding and decoding. Numerical evaluation in illustrative example networks and comparison with cheap relay cut-set bounds for half-duplex networks show that the proposed MDF protocols approach capacity in some ranges of channel gains. The main idea in the design of the protocols is the use of coding in interference networks that are created in different states or modes of a half-duplex network. Our results suggest that multistage half-duplex relaying with practical constraints on cooperation is comparable to point...

  6. Spatial light interference microscopy (SLIM).

    Science.gov (United States)

    Wang, Zhuo; Millet, Larry; Mir, Mustafa; Ding, Huafeng; Unarunotai, Sakulsuk; Rogers, John; Gillette, Martha U; Popescu, Gabriel

    2011-01-17

    We present spatial light interference microscopy (SLIM) as a new optical microscopy technique, capable of measuring nanoscale structures and dynamics in live cells via interferometry. SLIM combines two classic ideas in light imaging: Zernike's phase contrast microscopy, which renders high contrast intensity images of transparent specimens, and Gabor's holography, where the phase information from the object is recorded. Thus, SLIM reveals the intrinsic contrast of cell structures and, in addition, renders quantitative optical path-length maps across the sample. The resulting topographic accuracy is comparable to that of atomic force microscopy, while the acquisition speed is 1,000 times higher. We illustrate the novel insight into cell dynamics via SLIM by experiments on primary cell cultures from the rat brain. SLIM is implemented as an add-on module to an existing phase contrast microscope, which may prove instrumental in impacting the light microscopy field at a large scale.

  7. RNA干扰%RNA interference

    Institute of Scientific and Technical Information of China (English)

    江舸; 金由辛

    2003-01-01

    RNA干扰(RNA interference,RNAi)现象是指,当与内源性mRNA编码区某段序列同源的双链RNA(dsRNA)导入细胞后,该mRNA发生特异性的降解,而导致该基因表达的沉寂.这可能反映了生物防范病毒或转座子诱导DNA突变的一种防御机制.RNA干扰已经成为一种重要的研究基因功能的有力工具,并且有希望在对疾病的防御及治疗中发挥重要的作用.

  8. RNA干扰%RNA interference

    Institute of Scientific and Technical Information of China (English)

    陈凌; 郑祥雄

    2003-01-01

    @@ 1998年,Fire等人首次发现双链RNA(dsRNA)能够特异地抑制秀丽新小杆线虫中的纹状肌细胞unc-22基因的表达,这种抑制效能比单独应用正义或反义 RNA强十几倍;进一步研究还发现,用少量dsRNA处理的线虫就能呈现基因沉默的现象,并且该抑制现象可以传给第二代.他们将这一现象称为RNA干扰(RNA interference,RNAi)+[1].因为RNAi作用发生在转录后水平,所以又被称为转录后基因沉默(post-transcriptional gene silencing,PTGS).

  9. CDMA with interference cancellation for multiprobe missions

    Science.gov (United States)

    Divsalar, D.; Simon, M. K.

    1995-01-01

    Code division multiple-access spread spectrum has been proposed for use in future multiprobe/multispacecraft missions. This article considers a general parallel interference-cancellation scheme that significantly reduces the degradation effect of probe (user) interference but with a lesser implementation complexity than the maximum-likelihood technique. The scheme operates on the fact that parallel processing simultaneously removes from each probe (user) the total interference produced by the remaining most reliably received probes (users) accessing the channel. The parallel processing can be done in multiple stages. The proposed scheme uses tentative decision devices with different optimum thresholds at the multiple stages to produce the most reliably received data for generation and cancellation of probe/spacecraft interference. The one-stage interference cancellation was analyzed for two types of tentative decision devices, namely, hard and null zone decisions. Simulation results are given for one- and two-stage interference cancellation for equal as well as unequal received power probes.

  10. Filtering algorithm for dotted interferences

    Energy Technology Data Exchange (ETDEWEB)

    Osterloh, K., E-mail: kurt.osterloh@bam.de [Federal Institute for Materials Research and Testing (BAM), Division VIII.3, Radiological Methods, Unter den Eichen 87, 12205 Berlin (Germany); Buecherl, T.; Lierse von Gostomski, Ch. [Technische Universitaet Muenchen, Lehrstuhl fuer Radiochemie, Walther-Meissner-Str. 3, 85748 Garching (Germany); Zscherpel, U.; Ewert, U. [Federal Institute for Materials Research and Testing (BAM), Division VIII.3, Radiological Methods, Unter den Eichen 87, 12205 Berlin (Germany); Bock, S. [Technische Universitaet Muenchen, Lehrstuhl fuer Radiochemie, Walther-Meissner-Str. 3, 85748 Garching (Germany)

    2011-09-21

    An algorithm has been developed to remove reliably dotted interferences impairing the perceptibility of objects within a radiographic image. This particularly is a major challenge encountered with neutron radiographs collected at the NECTAR facility, Forschungs-Neutronenquelle Heinz Maier-Leibnitz (FRM II): the resulting images are dominated by features resembling a snow flurry. These artefacts are caused by scattered neutrons, gamma radiation, cosmic radiation, etc. all hitting the detector CCD directly in spite of a sophisticated shielding. This makes such images rather useless for further direct evaluations. One approach to resolve this problem of these random effects would be to collect a vast number of single images, to combine them appropriately and to process them with common image filtering procedures. However, it has been shown that, e.g. median filtering, depending on the kernel size in the plane and/or the number of single shots to be combined, is either insufficient or tends to blur sharp lined structures. This inevitably makes a visually controlled processing image by image unavoidable. Particularly in tomographic studies, it would be by far too tedious to treat each single projection by this way. Alternatively, it would be not only more comfortable but also in many cases the only reasonable approach to filter a stack of images in a batch procedure to get rid of the disturbing interferences. The algorithm presented here meets all these requirements. It reliably frees the images from the snowy pattern described above without the loss of fine structures and without a general blurring of the image. It consists of an iterative, within a batch procedure parameter free filtering algorithm aiming to eliminate the often complex interfering artefacts while leaving the original information untouched as far as possible.

  11. Quantum interference from remotely trapped ions

    Energy Technology Data Exchange (ETDEWEB)

    Gerber, S; Rotter, D; Hennrich, M; Blatt, R [Institute for Experimental Physics, University of Innsbruck, Technikerstr. 25, A-6020 Innsbruck (Austria); Rohde, F; Schuck, C; Almendros, M; Gehr, R; Dubin, F; Eschner, J [ICFO-Institut de Ciencies Fotoniques, Mediterranean Technology Park, Av del Canal OlImpic, E-08860 Castelldefels (Spain)], E-mail: francois.dubin@icfo.es

    2009-01-15

    We observe quantum interference of photons emitted by two continuously laser-excited single ions, independently trapped in distinct vacuum vessels. High contrast two-photon interference is observed in two experiments with different ion species, Ca{sup +} and Ba{sup +}. Our experimental findings are quantitatively reproduced by Bloch equation calculations. In particular, we show that the coherence of the individual resonance fluorescence light field is determined from the observed interference.

  12. Opportunistic Interference Alignment for Random Access Networks

    OpenAIRE

    Jin, Hu; Jeon, Sang-Woon; Jung, Bang Chul

    2015-01-01

    An interference management problem among multiple overlapped random access networks (RANs) is investigated, each of which operates with slotted ALOHA protocol. Assuming that access points and users have multiple antennas, a novel opportunistic interference alignment~(OIA) is proposed to mitigate interference among overlapped RANs. The proposed technique intelligently combines the transmit beamforming technique at the physical layer and the opportunistic packet transmission at the medium acces...

  13. Electromagnetic Interference (EMI) and TEMPEST Test Facility

    Data.gov (United States)

    Federal Laboratory Consortium — Electromagnetic Interference (EMI), Electromagnetic Compatibility (EMC) and TEMPEST testing are conducted at EPG's Blacktail Canyon Test Facility in one of its two...

  14. Impact of MIMO Co-Channel Interference

    DEFF Research Database (Denmark)

    Rahman, Muhammad Imadur; De Carvalho, Elisabeth; Prasad, Ramjee

    2007-01-01

    to cellular interference of some specific Multiple Input Multiple Output (MIMO) schemes on the same and other MIMO schemes. The goal is to study the impact of interference from MIMO schemes at a user located in the cell edge. Semi-Analytical evaluations of Signal to Interference and Noise Ratio (SINR) is done...... to find out the SINR statistics of different combinations of desired and interfering links. We have studied linear combining receivers for all the link combinations. Based on the current analysis, it is found that Space-Time Block Code (STBC) is a severe interferer compared to others, and specific...

  15. Interference Alignment Using Variational Mean Field Annealing

    DEFF Research Database (Denmark)

    Badiu, Mihai Alin; Guillaud, Maxime; Fleury, Bernard Henri

    2014-01-01

    We study the problem of interference alignment in the multiple-input multiple- output interference channel. Aiming at minimizing the interference leakage power relative to the receiver noise level, we use the deterministic annealing approach to solve the optimization problem. In the corresponding...... for interference alignment. We also show that the iterative leakage minimization algorithm by Gomadam et al. and the alternating minimization algorithm by Peters and Heath, Jr. are instances of our method. Finally, we assess the performance of the proposed algorithm through computer simulations....

  16. Using Interference to Block RFID Tags

    DEFF Research Database (Denmark)

    Krigslund, Rasmus; Popovski, Petar; Pedersen, Gert Frølund

    We propose a novel method to block RFID tags from responding, using intentional interference. We focus on the experimental evaluation, where we impose interference on the download and uplink, respectively. The results are positive, where modulated CCI shows most effective to block a tag.......We propose a novel method to block RFID tags from responding, using intentional interference. We focus on the experimental evaluation, where we impose interference on the download and uplink, respectively. The results are positive, where modulated CCI shows most effective to block a tag....

  17. Using Interference to Block RFID Tags

    DEFF Research Database (Denmark)

    Krigslund, Rasmus; Popovski, Petar; Pedersen, Gert Frølund

    We propose a novel method to block RFID tags from responding, using intentional interference. We focus on the experimental evaluation, where we impose interference on the download and uplink, respectively. The results are positive, where modulated CCI shows most effective to block a tag.......We propose a novel method to block RFID tags from responding, using intentional interference. We focus on the experimental evaluation, where we impose interference on the download and uplink, respectively. The results are positive, where modulated CCI shows most effective to block a tag....

  18. Dissipative time-dependent quantum transport theory: Quantum interference and phonon induced decoherence dynamics

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Yu, E-mail: zhy@yangtze.hku.hk; Chen, GuanHua, E-mail: ghc@everest.hku.hk [Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong (China); Yam, ChiYung [Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong (China); Beijing Computational Science Research Center, Beijing 100084 (China)

    2015-04-28

    A time-dependent inelastic electron transport theory for strong electron-phonon interaction is established via the equations of motion method combined with the small polaron transformation. In this work, the dissipation via electron-phonon coupling is taken into account in the strong coupling regime, which validates the small polaron transformation. The corresponding equations of motion are developed, which are used to study the quantum interference effect and phonon-induced decoherence dynamics in molecular junctions. Numerical studies show clearly quantum interference effect of the transport electrons through two quasi-degenerate states with different couplings to the leads. We also found that the quantum interference can be suppressed by the electron-phonon interaction where the phase coherence is destroyed by phonon scattering. This indicates the importance of electron-phonon interaction in systems with prominent quantum interference effect.

  19. Dissipative time-dependent quantum transport theory: Quantum interference and phonon induced decoherence dynamics.

    Science.gov (United States)

    Zhang, Yu; Yam, ChiYung; Chen, GuanHua

    2015-04-28

    A time-dependent inelastic electron transport theory for strong electron-phonon interaction is established via the equations of motion method combined with the small polaron transformation. In this work, the dissipation via electron-phonon coupling is taken into account in the strong coupling regime, which validates the small polaron transformation. The corresponding equations of motion are developed, which are used to study the quantum interference effect and phonon-induced decoherence dynamics in molecular junctions. Numerical studies show clearly quantum interference effect of the transport electrons through two quasi-degenerate states with different couplings to the leads. We also found that the quantum interference can be suppressed by the electron-phonon interaction where the phase coherence is destroyed by phonon scattering. This indicates the importance of electron-phonon interaction in systems with prominent quantum interference effect.

  20. On the Potential of Interference Rejection Combining in B4G Networks

    DEFF Research Database (Denmark)

    Tavares, Fernando Menezes Leitão; Berardinelli, Gilberto; Mahmood, Nurul Huda

    2013-01-01

    Beyond 4th Generation (B4G) local area networks will be characterized by the dense uncoordinated deployment of small cells. This paper shows that inter-cell interference, which is a main limiting factor in such networks, can be effectively contained using Interference Rejection Combining (IRC...... and coverage enhancing technique for B4G. The IRC gain mechanism depends strongly on the interference scenario and to some extent on the use of frequency reuse. These results are achieved with no coordination among cells and suggests that Multiple Input Multiple Output (MIMO) rank adaptation and IRC can...

  1. Impulsive interference in communication channels and its mitigation by SPART and other nonlinear filters

    Science.gov (United States)

    Nikitin, Alexei V.; Epard, Marc; Lancaster, John B.; Lutes, Robert L.; Shumaker, Eric A.

    2012-12-01

    A strong digital communication transmitter in close physical proximity to a receiver of a weak signal can noticeably interfere with the latter even when the respective channels are tens or hundreds of megahertz apart. When time domain observations are made in the signal chain of the receiver between the first mixer and the baseband, this interference is likely to appear impulsive. The impulsive nature of this interference provides an opportunity to reduce its power by nonlinear filtering, improving the quality of the receiver channel. This article describes the mitigation, by a particular nonlinear filter, of the impulsive out-of-band (OOB) interference induced in High Speed Downlink Packet Access (HSDPA) by WiFi transmissions, protocols which coexist in many 3G smartphones and mobile hotspots. Our measurements show a decrease in the maximum error-free bit rate of a 1.95 GHz HSDPA receiver caused by the impulsive interference from an OOB 2.4 GHz WiFi transmission, sometimes down to a small fraction of the rate observed in the absence of the interference. We apply a nonlinear SPART filter to recover a noticeable portion of the lost rate and maintain an error-free connection under much higher levels of the WiFi interference than a receiver that does not contain such a filter. These measurements support our wider investigation of OOB interference resulting from digital modulation, which appears impulsive in a receiver, and its mitigation by nonlinear filters.

  2. Interference and interactions in open quantum dots

    CERN Document Server

    Bird, J P; Ferry, D K; Moura, A P S; Lai, Y C; Indlekofer, K M

    2003-01-01

    In this report, we review the results of our joint experimental and theoretical studies of electron-interference, and interaction, phenomena in open electron cavities known as quantum dots. The transport through these structures is shown to be heavily influenced by the remnants of their discrete density of states, elements of which remain resolved in spite of the strong coupling that exists between the cavity and its reservoirs. The experimental signatures of this density of states are discussed at length in this report, and are shown to be related to characteristic wavefunction scarring, involving a small number of classical orbits. A semiclassical analysis of this behaviour shows it to be related to the effect of dynamical tunnelling, in which electrons are injected into the dot tunnel through classically forbidden regions of phase space, to access isolated regular orbits. The dynamical tunnelling gives rise to the formation of long-lived quasi-bound states in the open dots, and the many-body implications a...

  3. Measuring 36Ar without H35Cl interference

    Science.gov (United States)

    Saxton, John

    2015-04-01

    Noble gas measurements are usually made in static mode, when the mass spectrometer sensitivity is inversely proportional to volume: this makes the building of very large instruments to obtain high mass resolution impracticable. A particularly challenging interference has hitherto been H35Cl, which differs in mass from 36Ar by 1 part in 3937. We have developed a method which makes improved use of the available MRP to remove interferences, and used it to obtain HCl-free 36Ar measurements on a multicollector instrument with MRP of only ~6000 (MRP= mass resolving power = m/dm 5-95% on side of peak). By arranging that the target mass position on a minor isotope (e.g. 36Ar), from which the interference must be removed, coincides with the ~50% point on the side of a major isotope (e.g. 40Ar), it is possible both to set the mass accurately and to verify the mass position and stability during measurements. The peak top of 40Ar is measured in a separate mass step. Two small corrections are necessary. One compensates for the residual HCl tail at the 36Ar position. The other arises because the peak is not totally flat in the region of interest: 40Ar and 36Ar+HCl are measured on the peak top, whilst 36Ar is measured at the extreme edge, with slightly lower efficiency. The required correction parameters can be obtained from a series of air calibrations with different target/interference ratios. With samples containing 4x10-15to 3x10-14moles of 40Ar, 36Ar/40Ar was measured, without HCl interference, to a 1σ precision of 0.5%, only slightly worse than counting statistics. This is potentially useful for 40Ar/39Ar dating, where 36Ar is used to correct for trapped air, and may be particularly significant for smaller or younger samples.

  4. INTERFERENCE OF COUNTERPROPAGATING SHOCK WAVES

    Directory of Open Access Journals (Sweden)

    P. V. Bulat

    2015-03-01

    -dynamic discontinuities, the intensities corresponding to the transition from regular to irregular interference were described. Numerical calculations of the shock-wave structure transformation in the conditions of hysteresis were performed. The results were compared with the experiments carried out by hydraulic analogy method. Practical significance. Results of the work complement well the theory of stationary gas-dynamic discontinuities interference and can be used at designing of perspective images of supersonic and hypersonic aircraft.

  5. Exploiting CRISPR/Cas: Interference Mechanisms and Applications

    Directory of Open Access Journals (Sweden)

    André Plagens

    2013-07-01

    Full Text Available The discovery of biological concepts can often provide a framework for the development of novel molecular tools, which can help us to further understand and manipulate life. One recent example is the elucidation of the prokaryotic adaptive immune system, clustered regularly interspaced short palindromic repeats (CRISPR/CRISPR-associated (Cas that protects bacteria and archaea against viruses or conjugative plasmids. The immunity is based on small RNA molecules that are incorporated into versatile multi-domain proteins or protein complexes and specifically target viral nucleic acids via base complementarity. CRISPR/Cas interference machines are utilized to develop novel genome editing tools for different organisms. Here, we will review the latest progress in the elucidation and application of prokaryotic CRISPR/Cas systems and discuss possible future approaches to exploit the potential of these interference machineries.

  6. Intervention of radiation‐induced skin fibrosis by RNA interference

    DEFF Research Database (Denmark)

    Nawroth, Isabel

    and inhibit the expression of target proteins. Therefore, siRNAs are considered as promising therapeutics for treatment of various diseases including genetic and viral diseases, and cancer. In this study, the therapeutic potential of RNA interference was investigated as an intervention strategy for radiation......‐α (TNFα) production by macrophages might promote RIF. RNA interference (RNAi) is an evolutionary conserved gene‐silencing mechanism capable of degrading mRNA containing a homologous sequence to an exogenously introduced double stranded small interfering RNA (siRNA). These siRNAs can induce RNAi......‐induced skin fibrosis. Chitosan‐based nanoparticles (or polyplexes) formed by self‐assembly with siRNA were applied to overcome extracellular and intracellular barriers and deliver siRNA site‐specific. In this work we show that intraperitoneal administration of chitosan/DsiRNA nanoparticles targeting TNFα...

  7. Quantum interference in an asymmetric Mach-Zehnder interferometer

    Science.gov (United States)

    Trenti, A.; Borghi, M.; Mancinelli, M.; Price, H. M.; Fontana, G.; Pavesi, L.

    2016-08-01

    A re-visitation of the well known free space Mach-Zehnder interferometer is reported here. The coexistence between one-photon and two-photons interference from collinear color entangled photon pairs is investigated. Thisarises from an arbitrarily small unbalance in the arm transmittance. The tuning of such asymmetry is reflected in dramatic changes in the coincidence detection, revealing beatings between one particle and two particle interference patterns. In particular, the role of the losses and of the intrinsic phase imperfectness of the lossy beamsplitter are explored in a single-port excited Mach-Zehnder interferometer. This configuration is especially useful for quantum optics on a chip, where the guiding geometry forces photons to travel in the same spatial mode.

  8. Exploiting CRISPR/Cas: Interference Mechanisms and Applications

    Science.gov (United States)

    Richter, Hagen; Randau, Lennart; Plagens, André

    2013-01-01

    The discovery of biological concepts can often provide a framework for the development of novel molecular tools, which can help us to further understand and manipulate life. One recent example is the elucidation of the prokaryotic adaptive immune system, clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated (Cas) that protects bacteria and archaea against viruses or conjugative plasmids. The immunity is based on small RNA molecules that are incorporated into versatile multi-domain proteins or protein complexes and specifically target viral nucleic acids via base complementarity. CRISPR/Cas interference machines are utilized to develop novel genome editing tools for different organisms. Here, we will review the latest progress in the elucidation and application of prokaryotic CRISPR/Cas systems and discuss possible future approaches to exploit the potential of these interference machineries. PMID:23857052

  9. The Nature and Diagnosis of Interference Phenomena.

    Science.gov (United States)

    Denison, Norman

    1966-01-01

    The recognition of the systematic nature of the interference of the mother tongue when learning a second language is among the most significant advances in linguistics for the teaching and learning of foreign languages. The work of Weinreich showed that interference between language systems--the absorption of loan words, calques, and phonological,…

  10. Optimal interference code based on machine learning

    Science.gov (United States)

    Qian, Ye; Chen, Qian; Hu, Xiaobo; Cao, Ercong; Qian, Weixian; Gu, Guohua

    2016-10-01

    In this paper, we analyze the characteristics of pseudo-random code, by the case of m sequence. Depending on the description of coding theory, we introduce the jamming methods. We simulate the interference effect or probability model by the means of MATLAB to consolidate. In accordance with the length of decoding time the adversary spends, we find out the optimal formula and optimal coefficients based on machine learning, then we get the new optimal interference code. First, when it comes to the phase of recognition, this study judges the effect of interference by the way of simulating the length of time over the decoding period of laser seeker. Then, we use laser active deception jamming simulate interference process in the tracking phase in the next block. In this study we choose the method of laser active deception jamming. In order to improve the performance of the interference, this paper simulates the model by MATLAB software. We find out the least number of pulse intervals which must be received, then we can make the conclusion that the precise interval number of the laser pointer for m sequence encoding. In order to find the shortest space, we make the choice of the greatest common divisor method. Then, combining with the coding regularity that has been found before, we restore pulse interval of pseudo-random code, which has been already received. Finally, we can control the time period of laser interference, get the optimal interference code, and also increase the probability of interference as well.

  11. Plant genetics: when not to interfere.

    Science.gov (United States)

    Copenhaver, Gregory P

    2005-04-26

    New evidence suggests that the model plant Arabidopsis has two biochemically distinct pathways that produce genetic crossovers. Studies in several organisms have revealed that one kind of crossover regulation - crossover interference - is applied differently from species to species. Arabidopsis appears to use an interference system similar to that of budding yeast.

  12. Picture-Word Interference Is Semantically Based

    Science.gov (United States)

    Rosinski, Richard R.

    1977-01-01

    Analysis of the performance of second-, fourth-, sixth-grade, and college-level subjects on picture-word interference tasks indicated that distractor words belonging to the same semantic category as pictures produced more interference than either unrelated words or nonsense trigrams. (Author/JMB)

  13. Partial interference subspace rejection in CDMA systems

    DEFF Research Database (Denmark)

    Hansen, Henrik; Affes, Sofiene; Mewelstein, Paul

    2001-01-01

    Previously presented interference subspace rejection (ISR) proposed a family of new efficient multiuser detectors for CDMA. We reconsider in this paper the modes of ISR using decision feedback (DF). DF modes share similarities with parallel interference cancellation (PIC) but attempt to cancel...

  14. Is There Semantic Interference in Delayed Naming?

    NARCIS (Netherlands)

    Mädebach, A.; Oppermann, F.; Hantsch, A.; Curda, C.; Jescheniak, J.D.

    2011-01-01

    The semantic interference effect in the picture-word interference task is interpreted as an index of lexical competition in prominent speech production models. Janssen, Schirm, Mahon, and Caramazza (2008) challenged this interpretation on the basis of experiments with a novel version of this task, w

  15. Interference and the Law of Energy Conservation

    Science.gov (United States)

    Drosd, Robert; Minkin, Leonid; Shapovalov, Alexander S.

    2014-01-01

    Introductory physics textbooks consider interference to be a process of redistribution of energy from the wave sources in the surrounding space resulting in constructive and destructive interferences. As one can expect, the total energy flux is conserved. However, one case of apparent non-conservation energy attracts great attention. Imagine that…

  16. Is There Semantic Interference in Delayed Naming?

    Science.gov (United States)

    Madebach, Andreas; Oppermann, Frank; Hantsch, Ansgar; Curda, Christian; Jescheniak, Jorg D.

    2011-01-01

    The semantic interference effect in the picture-word interference task is interpreted as an index of lexical competition in prominent speech production models. Janssen, Schirm, Mahon, and Caramazza (2008) challenged this interpretation on the basis of experiments with a novel version of this task, which introduced a task-switching component.…

  17. 47 CFR 74.604 - Interference avoidance.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 4 2010-10-01 2010-10-01 false Interference avoidance. 74.604 Section 74.604 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) BROADCAST RADIO SERVICES EXPERIMENTAL RADIO... Stations § 74.604 Interference avoidance. (a) (b) Where two or more licensees are assigned a common...

  18. ``Quantum'' interference with bouncing drops

    Science.gov (United States)

    Bohr, Tomas; Andersen, Anders; Madsen, Jacob; Reichelt, Christian; Lautrup, Benny; Ellegaard, Clive; Levinsen, Mogens

    2013-11-01

    In a series of recent papers (most recently) Yves Couder and collaborators have explored the dynamics of walking drops on the surface of a vibrated bath of silicon oil and have demonstrated a close analogy to quantum phenomena. The bouncing drop together with the surface wave that it excites seems to be very similar to the pilot wave envisaged by de Broglie for quantum particles. In particular, have studied a double slit experiment with walking drops, where an interference pattern identical to the quantum version is found even though it is possible to follow the orbits of the drops and unambigously determine which slit it goes through, something which in quantum mechanics would be ruled out by the Heisenberg uncertainly relations. We have repeated the experiment and present a somewhat more complicated picture. Theoretically, we study a Schrödinger equation with a source term originating from a localised ``particle'' being simultaneously guided by the wave. We present simple solutions to such a field theory and discuss the fundamental difficulties met by such a theory in order to comply with quantum mechanics.

  19. Interference Channels with Strong Secrecy

    CERN Document Server

    He, Xiang

    2009-01-01

    It is known that given the real sum of two independent uniformly distributed lattice points from the same nested lattice codebook, the eavesdropper can obtain at most 1 bit of information per channel regarding the value of one of the lattice points. In this work, we study the effect of this 1 bit information on the equivocation expressed in three commonly used information theoretic measures, i.e., the Shannon entropy, the Renyi entropy and the min entropy. We then demonstrate its applications in an interference channel with a confidential message. In our previous work, we showed that nested lattice codes can outperform Gaussian codes for this channel when the achieved rate is measured with the weak secrecy notion. Here, with the Renyi entropy and the min entropy measure, we prove that the same secure degree of freedom is achievable with the strong secrecy notion as well. A major benefit of the new coding scheme is that the strong secrecy is generated from a single lattice point instead of a sequence of lattic...

  20. Alternative splicing interference by xenobiotics.

    Science.gov (United States)

    Zaharieva, Emanuela; Chipman, J Kevin; Soller, Matthias

    2012-06-14

    The protein coding sequence of most eukaryotic genes (exons) is interrupted by non-coding parts (introns), which are excised in a process termed splicing. To generate a mature messenger RNA (mRNA) hundreds of combinatorial protein-protein and RNA-protein interactions are required to splice out often very large introns with high fidelity and accuracy. Inherent to splicing is the use of alternative splice sites generating immense proteomic diversity from a limited number of genes. In humans, alternative splicing is a major mode of regulating gene expression, occurs in over 90% of genes and is particularly abundant in the brain. Only recently, it has been recognized that the complexity of the splicing process makes it susceptible to interference by various xenobiotics. These compounds include antineoplastic substances, commonly used drugs and food supplements and cause a spectrum of effects ranging from deleterious inhibition of general splicing to highly specific modifications of alternative splicing affecting only certain genes. Alterations in splicing have been implicated in numerous diseases such as cancer and neurodegeneration. Splicing regulation plays an important role in the execution of programmed cell death. The switch between anti- and pro-apoptotic isoforms by alternative splice site selection and misregulation of a number of splicing factors impacts on cell survival and disease. Here, our current knowledge is summarized on compounds interfering with general and alternative splicing and of the current methodology to study changes in these processes relevant to the field of toxicology and future risk assessments.

  1. Asymptomatic Bacteriuria and Bacterial Interference.

    Science.gov (United States)

    Nicolle, Lindsay E

    2015-10-01

    Asymptomatic bacteriuria is very common. In healthy women, asymptomatic bacteriuria increases with age, from bacteriuria, irrespective of age or gender. The prevalence is very high in residents of long-term-care facilities, from 25% to 50% of women and 15% to 40% of men. Escherichia coli is the most frequent organism isolated, but a wide variety of other organisms may occur. Bacteriuria may be transient or persist for a prolonged period. Pregnant women with asymptomatic bacteriuria identified in early pregnancy and who are untreated have a risk of pyelonephritis later in pregnancy of 20% to 30%. Bacteremia is frequent in bacteriuric subjects following mucosal trauma with bleeding, with 5% to 10% of patients developing severe sepsis or septic shock. These two groups with clear evidence of negative outcomes should be screened for bacteriuria and appropriately treated. Asymptomatic bacteriuria in other populations is benign and screening and treatment are not indicated. Antimicrobial treatment has no benefits but is associated with negative outcomes including reinfection with antimicrobial resistant organisms and a short-term increased frequency of symptomatic infection post-treatment. The observation of increased symptomatic infection post-treatment, however, has led to active investigation of bacterial interference as a strategy to prevent symptomatic episodes in selected high risk patients.

  2. Understanding quantum interference in General Nonlocality

    CERN Document Server

    Wanng, Hai-Jhun

    2010-01-01

    In this paper we attempt to give an understanding of quantum double-slit interference of fermions in the framework of General Nonlocality (GN) [J. Math. Phys. 49, 033513 (2008)] by studying the self-interaction of matter wave. From the metric of the GN, we derive a special formalism to interpret the interference contrast when the self-interaction is perturbative. According to the formalism, the characteristic of interference pattern is in agreement with experiment qualitatively. As examples, we apply the formalism to the cases governed by Schr\\"odinger current and Dirac current respectively, both of which are relevant to topology. The gap between these two cases corresponds to a spin-current effect, which is possible to test in the near future. In addition, a general interference formalism for both perturbative and non-perturbative self-interactions is presented. By analyzing the general formalism we predict that in the nonperturbative limit there is no interference at all.

  3. Phonon-Mediated Nonclassical Interference in Diamond

    Science.gov (United States)

    England, Duncan G.; Fisher, Kent A. G.; MacLean, Jean-Philippe W.; Bustard, Philip J.; Heshami, Khabat; Resch, Kevin J.; Sussman, Benjamin J.

    2016-08-01

    Quantum interference of single photons is a fundamental aspect of many photonic quantum processing and communication protocols. Interference requires that the multiple pathways through an interferometer be temporally indistinguishable to within the coherence time of the photon. In this Letter, we use a diamond quantum memory to demonstrate interference between quantum pathways, initially temporally separated by many multiples of the optical coherence time. The quantum memory can be viewed as a light-matter beam splitter, mapping a THz-bandwidth single photon to a variable superposition of the output optical mode and stored phononic mode. Because the memory acts both as a beam splitter and as a buffer, the relevant coherence time for interference is not that of the photon, but rather that of the memory. We use this mechanism to demonstrate nonclassical single-photon and two-photon interference between quantum pathways initially separated by several picoseconds, even though the duration of the photons themselves is just ˜250 fs .

  4. Improved CDMA Performance Using Parallel Interference Cancellation

    Science.gov (United States)

    Simon, Marvin; Divsalar, Dariush

    1995-01-01

    This report considers a general parallel interference cancellation scheme that significantly reduces the degradation effect of user interference but with a lesser implementation complexity than the maximum-likelihood technique. The scheme operates on the fact that parallel processing simultaneously removes from each user the interference produced by the remaining users accessing the channel in an amount proportional to their reliability. The parallel processing can be done in multiple stages. The proposed scheme uses tentative decision devices with different optimum thresholds at the multiple stages to produce the most reliably received data for generation and cancellation of user interference. The 1-stage interference cancellation is analyzed for three types of tentative decision devices, namely, hard, null zone, and soft decision, and two types of user power distribution, namely, equal and unequal powers. Simulation results are given for a multitude of different situations, in particular, those cases for which the analysis is too complex.

  5. Periods of weed interference in cowpea

    Directory of Open Access Journals (Sweden)

    Maria José Pinheiro Corrêa

    2015-12-01

    Full Text Available This work aimed to determine the periods weed interference in cowpea. The experimental design was randomized blocks, and the treatments consisted of periods of control or coexistence with the culture. The periods of control or weed coexistence after culture emergence were: 0-10, 0-20, 0-30, 0-40, 0-50, 0-60 and 0 – 80 days after crop emergence. The main weed density were: AlternantheratenellaColla,CyperusrotundusL., Digitariaciliaris(Retz. Koeler, Eleusineindica(L.Gaertn,MollugoverticillataL.Considering 5% of tolerance in cowpea yield reduction, the period prior interference was 8 days after emergence (DAE, total period of interference prevention was 53 DAE and critical period of interference prevention between 8 and 53 DAE. Weed interference reduced the grainyield up to 46%.

  6. Laser self-mixing interference fiber sensor

    Institute of Scientific and Technical Information of China (English)

    Zhu Jun; Zhao Yan; Jin Guo-fan

    2008-01-01

    Fibre sensors exhibit a number of advantages over other sensors such as high sensitivity, electric insulation, corrosion resistance, interference rejection and so on. And laser elf-mixing interference can accurately detect the phase difference of feedback light. In this paper, a novel laser self-mixing interference fibre sensor that combines the advantages of fibre sensors with those of laser self-mixing interference is presented. Experimental configurations are set up to study the relationship between laser power output and phase of laser feedback light when the fibre trembles or when the fibre is stretched or pressed. The theoretical analysis of pressure sensors based on laser self-mixing interference is indicated to accord with the experimental results.

  7. Interference Alignment for Clustered Multicell Joint Decoding

    CERN Document Server

    Chatzinotas, Symeon

    2010-01-01

    Multicell joint processing has been proven to be very efficient in overcoming the interference-limited nature of the cellular paradigm. However, for reasons of practical implementation global multicell joint decoding is not feasible and thus clusters of cooperating Base Stations have to be considered. In this context, intercluster interference has to be mitigated in order to harvest the full potential of multicell joint processing. In this paper, four scenarios of intercluster interference are investigated, namely a) global multicell joint processing, b) interference alignment, c) resource division multiple access and d) cochannel interference allowance. Each scenario is modelled and analyzed using the per-cell ergodic sum-rate capacity as a figure of merit. In this process, a number of theorems are derived for analytically expressing the asymptotic eigenvalue distributions of the channel covariance matrices. The analysis is based on principles from Free Probability theory and especially properties in the R a...

  8. A novel structure of silicon-on-insulator microring biosensor based on Young's two-slit interference and its simulation

    Institute of Scientific and Technical Information of China (English)

    Su Baoqing; Wang Chunxia; Kan Qiang; Li Junhua; Xie Yiyang; Wang Zhenzhen; Chen Hongda

    2011-01-01

    A novel silicon-on-insulator microring biosensor based on Young's twoslit interference has been demonstrated.The transducer signal from electric field intensity distribution on the interference screen is given by using the transfer matrix method (TMM) and two-slit interference principle.The result shows that the structure we propose is advantageous for sensing as the interference pattern is very sensitive to the ambient refractive index around the microring.A small perturbation in refractive index around the microring △nc will result in a notable shift of destructive interference points (DIPs) on the interference screen.By detecting the shift of the DIPs,the ambient refractive index change can be obtained.

  9. Inhibition of proliferation of human non-Hodgkin's lymphoma Raji cells by small interference RNA silencing Pokemon gene%siRNA 沉默 Pokemon 基因抑制人非霍奇金淋巴瘤 Raji细胞的增殖

    Institute of Scientific and Technical Information of China (English)

    董珂; 蒲业迪; 刘琼; 代广霞; 李丽珍; 李颢; 王玲玲; 王鲁群

    2014-01-01

    Objective Small interference RNA ( siRNA) was used to silence Pokemon gene in human non-Hodgkin's lymphoma Raji cells, then to observe the change of proliferation of Raji cells and explore its possible molecular mecha-nisms.Methods Pokemon-targeted siRNA was constructed with lentivirus vector and transfected to Raji cells. RT-PCR and Western blotting were adopted to confirm the silence effect of Pokemon gene in Raji cells, which were then used to determine the mRNA and protein expressions of bcl-6 and mutant p53.Flow cytometry was used to detect the cell apoptosis of each group.Results Pokemon-siRNA constructed with lentivirus vector could efficiently silence the expression of Pokemon gene in Raji cell (P<0.05).After that, the mRNA and protein expressions of bcl-6 and mutant p53 were significantly decreased (P<0.05) and the cell apoptosis rate was markedly elevated compared with the controls.Conclusion The siRNA Pokemon gene silencing promotes human non-Hodgkin's lymphoma Raji cells apoptosis by lowering the expressions of bcl-6 and mutant p53 gene and protein and inhibiting the proliferation.Poke-mon gene is expected to become a new target for non-Hodgkin's lymphoma treatment.%目的:采用siRNA干扰技术沉默人非霍奇金淋巴瘤Raji细胞中Pokemon基因,观察Raji细胞增殖活性的变化,并探讨其可能的分子机制。方法构建靶向Pokemon基因的siRNA重组慢病毒载体并转染Raji细胞。采用实时定量PCR法和Western blotting法检测Raji细胞Pokemon基因的沉默效果,在Raji细胞中沉默Pokemon基因的表达后采用实时定量PCR法和Western blotting法检测bcl-6和突变型p53表达水平的变化;采用流式细胞术检测Pokemon基因沉默后Raji细胞凋亡的情况。结果利用Pokemon靶向siRNA重组慢病毒载体感染Raji细胞有效沉默Raji细胞Pokemon基因表达(P<0.05)。沉默Pokemon基因后,bcl-6和突变型p53基因和蛋白表达均显著降低(P<0.05)

  10. 小干扰RNA抑制neuro-2a细胞内源β位淀粉样前体蛋白裂解酶1基因的表达%Small interference RNA inhibits the endogenous expression of beta-site APP cleaving enzyme-1 protein in neuro-2a cells

    Institute of Scientific and Technical Information of China (English)

    张小勤; 李峰; 赵艳; 彭映基; 潘玉春; 崔芳岩; 孟和

    2007-01-01

    目的:分析小干扰RNA(small interference RNA,siRNA)抑制neuro-2a细胞内源β位淀粉样前体蛋白裂解酶1基因(Beta-site APP cleaving enzyme protein,BACE1)的表达情况.方法:实验于2004-12/2006-06在中山大学中山医学院和上海交通大学农业与生物学院完成.①用脂质体将EGFP基因表达载体pEGFP-C1 Vector和体外转录合成的针对EGFP基因的小干扰RNA(siEGFP)分别或同时转染neuro-2a细胞,在倒置荧光显微镜下计算EGFP在neuro-2a细胞中的表达率.②将体外转录合成的siBACE1-1,siBACE1-2,siBACE1-3转染neuro-2a细胞,干扰24,48,72 h后分别用Real time RT-PCR定量分析siBACE1对内源BACE1基因表达的抑制率和干扰的时效性.结果:①外源EGFP基因转染neuro-2a细胞后,43%neuro-2a细胞高表达EGFP蛋白.通过转染siEGFP则可有效抑制EGFP基因表达.②3个干扰位点的siBACE1对BACE1基因表达有不同的抑制效率,siBACE1-3使BACE1 mRNA表达水平下降60%,siBACE1-1为13%,siBACE1-2对BACE1 mRNA无明显的抑制作用.③siBACE1抑制内源BACE1基因的表达与干扰时间相关,siBACE1干扰24 h、48 h后BACE1 mRNA的表达与正常组无明显差异(P>0.05),但干扰72 h后,siBACE1-3和siBACE1-1均使BACE1 mRNA表达量下降.结论:体外转录合成的siBACE1能有效抑制neuro-2a细胞内源BACE1基因表达,其抑制率与BACE1基因的干扰位点和干扰时间相关.

  11. Emerging strategies for RNA interference (RNAi) applications in insects.

    Science.gov (United States)

    Nandety, Raja Sekhar; Kuo, Yen-Wen; Nouri, Shahideh; Falk, Bryce W

    2015-01-01

    RNA interference (RNAi) in insects is a gene regulatory process that also plays a vital role in the maintenance and in the regulation of host defenses against invading viruses. Small RNAs determine the specificity of the RNAi through precise recognition of their targets. These small RNAs in insects comprise small interfering RNAs (siRNAs), micro RNAs (miRNAs) and Piwi interacting RNAs (piRNAs) of various lengths. In this review, we have explored different forms of the RNAi inducers that are presently in use, and their applications for an effective and efficient fundamental and practical RNAi research with insects. Further, we reviewed trends in next generation sequencing (NGS) technologies and their importance for insect RNAi, including the identification of novel insect targets as well as insect viruses. Here we also describe a rapidly emerging trend of using plant viruses to deliver the RNAi inducer molecules into insects for an efficient RNAi response.

  12. Electro-optic cosite interference mitigation

    Science.gov (United States)

    Bruno, Jonathan R.; Prucnal, Paul

    2010-02-01

    Cosite interference can be roughly defined as the unintentional degradation of receiver functionality as a result of close proximity to a powerful in-band transmission source; for instance receivers located on modern cellular communication towers often suffer as a result of co-site interference introduced through space limitations and overcrowding. The Opto- Cancellation system was designed as a novel approach to mitigate the problem of co-site interference. The system accomplishes interference cancellation through the integration of traditional EO telecommunications devices into an otherwise wholly RF communications system. This paper will discuss the integration of EO components into an RF communications system as well as the non-traditional integration of EO components to perform co-site interference mitigation. To date the system has performed cancellation up to 80 dB reduction of a narrowband signal and 45 dB reduction of a 100 MHz bandwidth signal without affecting the receiver's signal of interest. The system is able to perform extremely wide-band interference cancellation by utilizing the large instantaneous bandwidth inherent in a fast EO modulator, largely addressing the limitations of traditional RF interference cancellation/mitigation techniques such as digital sampling and filtering.

  13. Wave and particle in molecular interference lithography.

    Science.gov (United States)

    Juffmann, Thomas; Truppe, Stefan; Geyer, Philipp; Major, András G; Deachapunya, Sarayut; Ulbricht, Hendrik; Arndt, Markus

    2009-12-31

    The wave-particle duality of massive objects is a cornerstone of quantum physics and a key property of many modern tools such as electron microscopy, neutron diffraction or atom interferometry. Here we report on the first experimental demonstration of quantum interference lithography with complex molecules. Molecular matter-wave interference patterns are deposited onto a reconstructed Si(111) 7x7 surface and imaged using scanning tunneling microscopy. Thereby both the particle and the quantum wave character of the molecules can be visualized in one and the same image. This new approach to nanolithography therefore also represents a sensitive new detection scheme for quantum interference experiments.

  14. Wave and Particle in Molecular Interference Lithography

    CERN Document Server

    Juffmann, Thomas; Geyer, Philipp; Major, Andras G; Deachapunya, Sarayut; Ulbricht, Hendrik; Arndt, Markus; 10.1103/PhysRevLett.103.263601

    2010-01-01

    The wave-particle duality of massive objects is a cornerstone of quantum physics and a key property of many modern tools such as electron microscopy, neutron diffraction or atom interferometry. Here we report on the first experimental demonstration of quantum interference lithography with complex molecules. Molecular matter-wave interference patterns are deposited onto a reconstructed Si(111) 7x7 surface and imaged using scanning tunneling microscopy. Thereby both the particle and the quantum wave character of the molecules can be visualized in one and the same image. This new approach to nanolithography therefore also represents a sensitive new detection scheme for quantum interference experiments.

  15. Multimode Hong-Ou-Mandel interference

    CERN Document Server

    Walborn, S P; Pádua, S; Monken, C H

    2003-01-01

    We consider multimode two-photon interference at a beam splitter by photons created by spontaneous parametric down-conversion. The resulting interference pattern is shown to depend upon the transverse spatial symmetry of the pump beam. In an experiment, we employ the first-order Hermite-Gaussian modes in order to show that, by manipulating the pump beam, one can control the resulting two-photon interference behavior. We expect these results to play an important role in the engineering of quantum states of light for use in quantum information processing and quantum imaging.

  16. Fano interference in two-photon transport

    Science.gov (United States)

    Xu, Shanshan; Fan, Shanhui

    2016-10-01

    We present a general input-output formalism for the few-photon transport in multiple waveguide channels coupled to a local cavity. Using this formalism, we study the effect of Fano interference in two-photon quantum transport. We show that the physics of Fano interference can manifest as an asymmetric spectral line shape in the frequency dependence of the two-photon correlation function. The two-photon fluorescence spectrum, on the other hand, does not exhibit the physics of Fano interference.

  17. CORRELATED INTERFERENCE CANCELLATION FOR IR-UWB

    Institute of Scientific and Technical Information of China (English)

    Zhang Zaichen; Yu Xutao; Bi Guangguo

    2008-01-01

    In this letter,we propose a hybrid analog/digital detection algorithm,the Correlated Interference Cancellation (CIC) algorithm,for Impulse Radio Ultra-WideBand (IR-UWB) system. The CIC algorithm correlates received signal with its delayed versions in the analog domain and samples the correlation output at the symbol rate. The symbol rate samples are processed in the digital domain to perform interference cancellation. Therefore,CIC works for high data rate systems with heavy InterSymbol Interference (ISI). Simulation results show that CIC achieves good performance in typical UWB channels.

  18. Cross-limb Interference during motor learning

    DEFF Research Database (Denmark)

    Lauber, Benedikt; Jensen, Jesper Lundbye; Keller, Martin

    2013-01-01

    investigate if this interference effect can also be observed in the limb contralateral to the trained one. Therefore, five different groups practiced a ballistic finger flexion task followed by an interfering visuomotor accuracy task with the same limb. Performance in the ballistic task was tested before...... to the trained hand following ballistic training and decreased during accuracy training of the ipsilateral hand. The results demonstrate that contralateral interference effects may occur, and that interference depends on the level of skill acquisition in the interfering motor task. This finding might...

  19. Study of the Interference Affecting the Performance of the Theremin

    Directory of Open Access Journals (Sweden)

    Carmen Bachiller Martín

    2012-01-01

    Full Text Available The theremin is one of the earliest electronic musical instruments. It is named after the Russian physics Professor Lev S. Termen who invented it in 1919. This musical instrument belongs to a very short list of devices which are played without physical contact between the musician and the instrument. theremin players complain about the interference that any object in a radius of approximately 3 meters produces when playing the theremin, modifying the intonation of the instrument. This is a problem when playing in small scenarios, with other musicians which move around it. With the aim of reducing the degree of interference from nearby obstacles, some metallic isolating bars conforming an antenna array can be placed around the theremin pitch antenna. The paper shows different simulations calculated with the commercial software Ansoft HFSS, a tool which allows three-dimensional full wave electromagnetic field simulation, with radio frequencies, millimeter and micro waves, and experimental measures, both showing a reduction in the effect of the interference.

  20. Airborne system for detection and location of radio interference sources

    Science.gov (United States)

    Audone, Bruno; Pastore, Alberto

    1992-11-01

    The rapid expansion of telecommunication has practically saturated every band of Radio Frequency Spectrum; a similar expansion of electrical and electronic devices has affected all radio communications which are, in some way, influenced by a large amount of interferences, either intentionally or unintentionally produced. Operational consequences of these interferences, particularly in the frequency channels used for aeronautical services, can be extremely dangerous, making mandatory a tight control of Electromagnetic Spectrum. The present paper analyzes the requirements and the problems related to the surveillance, for civil application, of the Electromagnetic Spectrum between 20 and 1000 MHz, with particular attention to the detection and location of radio interference sources; after a brief introduction and the indication of the advantages of an airborne versus ground installation, the airborne system designed by Alenia in cooperation with Italian Ministry of Post and Telecommunication, its practical implementation and the prototype installation on board of a small twin turboprop aircraft for experimentation purposes is presented. The results of the flight tests are also analyzed and discussed.

  1. Intervention of radiation‐induced skin fibrosis by RNA interference

    DEFF Research Database (Denmark)

    Nawroth, Isabel

    ‐α (TNFα) production by macrophages might promote RIF. RNA interference (RNAi) is an evolutionary conserved gene‐silencing mechanism capable of degrading mRNA containing a homologous sequence to an exogenously introduced double stranded small interfering RNA (siRNA). These siRNAs can induce RNAi......, lung, spleen and kidney did not reveal cytotoxic side effects after long‐term administration of the nanoparticle formulations. This nanoparticlebased RNAi approach represents a novel approach to prevent RIF in mice with potential application to improve clinical radiation therapeutic strategies....

  2. Role of RNA interference in plant improvement

    Science.gov (United States)

    Jagtap, Umesh Balkrishna; Gurav, Ranjit Gajanan; Bapat, Vishwas Anant

    2011-06-01

    Research to alter crops for their better performance involving modern technology is underway in numerous plants, and achievements in transgenic plants are impacting crop improvements in unparalleled ways. Striking progress has been made using genetic engineering technology over the past two decades in manipulating genes from diverse and exotic sources, and inserting them into crop plants for inducing desirable characteristics. RNA interference (RNAi) has recently been identified as a natural mechanism for regulation of gene expression in all higher organisms from plants to humans and promises greater accuracy and precision to plant improvement. The expression of any gene can be down-regulated in a highly explicit manner exclusive of affecting the expression of any other gene by using RNAi technologies. Additional research in this field has been focused on a number of other areas including microRNAs, hairpin RNA, and promoter methylation. Manipulating new RNAi pathways, which generate small RNA molecules to amend gene expression in crops, can produce new quality traits and having better potentiality of protection against abiotic and biotic stresses. Nutritional improvement, change in morphology, or enhanced secondary metabolite synthesis are some of the other advantages of RNAi technology. In addition to its roles in regulating gene expression, RNAi is also used as a natural defense mechanism against molecular parasites such as jumping genes and viral genetic elements that affect genome stability. Even though much advancement has been made on the field of RNAi over the preceding few years, the full prospective of RNAi for crop improvement remains to be fully realized. The intricacy of RNAi pathway, the molecular machineries, and how it relates to plant development are still to be explained.

  3. MIMO Networks: the Effects of Interference

    CERN Document Server

    Chiani, Marco; Shin, Hyundong

    2008-01-01

    Multiple-input/multiple-output (MIMO) systems promise enormous capacity increase and are being considered as one of the key technologies for future wireless networks. However, the decrease in capacity due to the presence of interferers in MIMO networks is not well understood. In this paper, we develop an analytical framework to characterize the capacity of MIMO communication systems in the presence of multiple MIMO co-channel interferers and noise. We consider the situation in which transmitters have no information about the channel and all links undergo Rayleigh fading. We first generalize the known determinant representation of hypergeometric functions with matrix arguments to the case when the argument matrices have eigenvalues of arbitrary multiplicity. This enables the derivation of the ergodic capacity expressions for MIMO systems in the presence of multiple MIMO interferers. Our analysis is valid for any number of interferers, each with arbitrary number of antennas having possibly unequal power levels....

  4. Signal interference RF photonic bandstop filter.

    Science.gov (United States)

    Aryanfar, Iman; Choudhary, Amol; Shahnia, Shayan; Pagani, Mattia; Liu, Yang; Marpaung, David; Eggleton, Benjamin J

    2016-06-27

    In the microwave domain, signal interference bandstop filters with high extinction and wide stopbands are achieved through destructive interference of two signals. Implementation of this filtering concept using RF photonics will lead to unique filters with high performance, enhanced tuning range and reconfigurability. Here we demonstrate an RF photonic signal interference filter, achieved through the combination of precise synthesis of stimulated Brillouin scattering (SBS) loss with advanced phase and amplitude tailoring of RF modulation sidebands. We achieve a square-shaped, 20-dB extinction RF photonic filter over a tunable bandwidth of up to 1 GHz with a central frequency tuning range of 16 GHz using a low SBS loss of ~3 dB. Wideband destructive interference in this novel filter leads to the decoupling of the filter suppression from its bandwidth and shape factor. This allows the creation of a filter with all-optimized qualities.

  5. Radio VLBI and the quantum interference paradox

    CERN Document Server

    Singal, Ashok K

    2016-01-01

    We address here the question of interference of radio signals from astronomical sources like distant quasars, in a very long baseline interferometer (VLBI), where two (or more) distantly located radio telescopes (apertures), receive simultaneous signal from the sky. In an equivalent optical two-slit experiment, it is generally argued that for the photons involved in the interference pattern on the screen, it is not possible, even in principle, to ascertain which of the two slits a particular photon went through. It is argued that any procedure to ascertain this destroys the interference pattern. But in the case of the modern radio VLBI, it is a routine matter to record the phase and amplitude of the voltage outputs from the two radio antennas on a recording media separately and then do the correlation between the two recorded signals later in an offline manner. Does this not violate the quantum interference principle? We provide a resolution of this problem here.

  6. Exploiting Genetic Interference for Antiviral Therapy.

    Science.gov (United States)

    Tanner, Elizabeth J; Kirkegaard, Karla A; Weinberger, Leor S

    2016-05-01

    Rapidly evolving viruses are a major threat to human health. Such viruses are often highly pathogenic (e.g., influenza virus, HIV, Ebola virus) and routinely circumvent therapeutic intervention through mutational escape. Error-prone genome replication generates heterogeneous viral populations that rapidly adapt to new selection pressures, leading to resistance that emerges with treatment. However, population heterogeneity bears a cost: when multiple viral variants replicate within a cell, they can potentially interfere with each other, lowering viral fitness. This genetic interference can be exploited for antiviral strategies, either by taking advantage of a virus's inherent genetic diversity or through generating de novo interference by engineering a competing genome. Here, we discuss two such antiviral strategies, dominant drug targeting and therapeutic interfering particles. Both strategies harness the power of genetic interference to surmount two particularly vexing obstacles-the evolution of drug resistance and targeting therapy to high-risk populations-both of which impede treatment in resource-poor settings.

  7. Fight plant pests using RNA interference

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    @@ CAS plant physiologists have recently invented a plant-mediated RNA interference (RNAi) technique to effectively and specifically control the gene expression of the cotton bollworm (Helicoverpa armigera) and stunt its growth.

  8. Parallel interference cancellation for CDMA applications

    Science.gov (United States)

    Divsalar, Dariush (Inventor); Simon, Marvin K. (Inventor); Raphaeli, Dan (Inventor)

    1997-01-01

    The present invention provides a method of decoding a spread spectrum composite signal, the composite signal comprising plural user signals that have been spread with plural respective codes, wherein each coded signal is despread, averaged to produce a signal value, analyzed to produce a tentative decision, respread, summed with other respread signals to produce combined interference signals, the method comprising scaling the combined interference signals with a weighting factor to produce a scaled combined interference signal, scaling the composite signal with the weighting factor to produce a scaled composite signal, scaling the signal value by the complement of the weighting factor to produce a leakage signal, combining the scaled composite signal, the scaled combined interference signal and the leakage signal to produce an estimate of a respective user signal.

  9. Interference Between Lactobacilli And Group A Streptococcus ...

    African Journals Online (AJOL)

    Interference Between Lactobacilli And Group A Streptococcus pyogenes : An Expansion To The Concept Of ... New Egyptian Journal of Microbiology ... However, little is known about their health benefits in respiratory and skin infections.

  10. Grassmannian Differential Limited Feedback for Interference Alignment

    CERN Document Server

    Ayach, Omar El

    2011-01-01

    Channel state information (CSI) in the interference channel can be used to precode, align, and reduce the dimension of interference at the receivers, to achieve the channel's maximum multiplexing gain, through what is known as interference alignment. Most interference alignment algorithms require knowledge of all the interfering channels to compute the alignment precoders. CSI, considered available at the receivers, can be shared with the transmitters via limited feedback. When alignment is done by coding over frequency extensions in a single antenna system, the required CSI lies on the Grassmannian manifold and its structure can be exploited in feedback. Unfortunately, the number of channels to be shared grows with the square of the number of users creating too much overhead with conventional feedback methods. This paper proposes Grassmannian differential feedback to reduce feedback overhead by exploiting both the channel's temporal correlation and Grassmannian structure. The performance of the proposed algo...

  11. Conducted Electromagnetic Interference (EMI) in Smart Grids

    CERN Document Server

    Smolenski, Robert

    2012-01-01

    As power systems develop to incorporate renewable energy sources, the delivery systems may be disrupted by the changes involved. The grid’s technology and management must be developed to form Smart Grids between consumers, suppliers and producers. Conducted Electromagnetic Interference (EMI) in Smart Grids considers the specific side effects related to electromagnetic interference (EMI) generated by the application of these Smart Grids. Conducted Electromagnetic Interference (EMI) in Smart Grids presents specific EMI conducted phenomena as well as effective methods to filter and handle them once identified. After introduction to Smart Grids, the following sections cover dedicated methods for EMI reduction and potential avenues for future development including chapters dedicated to: •potential system services, •descriptions of the EMI spectra shaping methods, •methods of interference voltage compensation, and theoretical analysis of experimental results.  By focusing on these key aspects, Conducted El...

  12. Automotive radar - investigation of mutual interference mechanisms

    Science.gov (United States)

    Goppelt, M.; Blöcher, H.-L.; Menzel, W.

    2010-09-01

    In the past mutual interference between automotive radar sensors has not been regarded as a major problem. With an increasing number of such systems, however, this topic is receiving more and more attention. The investigation of mutual interference and countermeasures is therefore one topic of the joint project "Radar on Chip for Cars" (RoCC) funded by the German Federal Ministry of Education and Research (BMBF). RoCC's goal is to pave the way for the development of high-performance, low-cost 79 GHz radar sensors based on Silicon-Germanium (SiGe) Monolithic Microwave Integrated Circuits (MMICs). This paper will present some generic interference scenarios and report on the current status of the analysis of interference mechanisms.

  13. Interference Cancellation System Design Using GNU Radio

    Science.gov (United States)

    2015-12-01

    ARL-TR-7546 ● DEC 2015 US Army Research Laboratory Interference Cancellation System Design Using GNU Radio by Jan Paolo...Interference Cancellation System Design Using GNU Radio by Jan Paolo Acosta Sensors and Electron Devices Directorate, ARL...Design Using GNU Radio 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) Jan Paolo Acosta 5d. PROJECT NUMBER

  14. Test Anxiety: Cognitive Interference or Inadequate Preparation

    Science.gov (United States)

    1990-08-01

    anxiety interferes with students’ recall of prior learning on examinations. This so called interference model has recently been challenged by an...instructions, sometimes called ego involving instructions, suggesting that performance on the research task is related to students’ ability or school...New York: Irvington Press. Culler, R. E., & Holahan , C. (1980). Test taking and academic performance: The effects of study-related behaviors

  15. Simulating interference and diffraction in instructional laboratories

    Science.gov (United States)

    Maurer, L.

    2013-03-01

    Studieshave shown that standard lectures and instructional laboratory experiments are not effective at teaching interference and diffraction. In response, the author created an interactive computer program that simulates interference and diffraction effects using the finite difference time domain method. The software allows students to easily control, visualize and quantitatively measure the effects. Students collected data from simulations as part of their laboratory exercise, and they performed well on a subsequent quiz, showing promise for this approach.

  16. Phase dependent interference effects on atomic excitation

    CERN Document Server

    Jha, Pankaj K; Sautenkov, Vladimir A; Rostovtsev, Yuri V; Scully, Marlan O

    2011-01-01

    We present an experimental and theoretical study of phase-dependent interference effects in multi-photon excitation under bichromatic radio-frequency (rf) field. Using an intense rf pulse, we study the interference between the three-photon and one-photon transition between the Zeeman sub-levels of the ground state of $^{87}$Rb that allows us to determine the carrier-envelope phase of the fields even for long pulses.

  17. Visual Working Memory Capacity and Proactive Interference

    OpenAIRE

    Hartshorne, Joshua K.

    2008-01-01

    BACKGROUND: Visual working memory capacity is extremely limited and appears to be relatively immune to practice effects or the use of explicit strategies. The recent discovery that visual working memory tasks, like verbal working memory tasks, are subject to proactive interference, coupled with the fact that typical visual working memory tasks are particularly conducive to proactive interference, suggests that visual working memory capacity may be systematically under-estimated. METHODOLOGY/P...

  18. Fading and interference mitigation in wireless communications

    CERN Document Server

    Panic, Stefan; Anastasov, Jelena; Spalevic, Petar

    2013-01-01

    The rapid advancement of various wireless communication system services has created the need to analyze the possibility of their performance improvement. Introducing the basic principles of digital communications performance analysis and its mathematical formalization, Fading and Interference Mitigation in Wireless Communications will help you stay up to date with recent developments in the performance analysis of space diversity reception over fading channels in the presence of cochannel interference.The book presents a unified method for computing the performance of digital communication sys

  19. Interference Alignment via Improved Subspace Conditioning

    CERN Document Server

    Kim, Douglas

    2010-01-01

    For the K user, single input single output (SISO), frequency selective interference channel, a new low complexity transmit beamforming design that improves the achievable sum rate is presented. Jointly employing the interference alignment (IA) scheme presented by Cadambe and Jafar in [1] and linear minimum mean square error (MMSE) decoding at the transmitters and receivers, respectively, the new IA precoding design improves the average sum rate while preserving the achievable degrees of freedom of the Cadambe and Jafar scheme, K/2.

  20. Investigation of Interference Models for RFID Systems

    Directory of Open Access Journals (Sweden)

    Linchao Zhang

    2016-02-01

    Full Text Available The reader-to-reader collision in an RFID system is a challenging problem for communications technology. In order to model the interference between RFID readers, different interference models have been proposed, mainly based on two approaches: single and additive interference. The former only considers the interference from one reader within a certain range, whereas the latter takes into account the sum of all of the simultaneous interferences in order to emulate a more realistic behavior. Although the difference between the two approaches has been theoretically analyzed in previous research, their effects on the estimated performance of the reader-to-reader anti-collision protocols have not yet been investigated. In this paper, the influence of the interference model on the anti-collision protocols is studied by simulating a representative state-of-the-art protocol. The results presented in this paper highlight that the use of additive models, although more computationally intensive, is mandatory to improve the performance of anti-collision protocols.

  1. Cross-limb interference during motor learning.

    Directory of Open Access Journals (Sweden)

    Benedikt Lauber

    Full Text Available It is well known that following skill learning, improvements in motor performance may transfer to the untrained contralateral limb. It is also well known that retention of a newly learned task A can be degraded when learning a competing task B that takes place directly after learning A. Here we investigate if this interference effect can also be observed in the limb contralateral to the trained one. Therefore, five different groups practiced a ballistic finger flexion task followed by an interfering visuomotor accuracy task with the same limb. Performance in the ballistic task was tested before the training, after the training and in an immediate retention test after the practice of the interference task for both the trained and the untrained hand. After training, subjects showed not only significant learning and interference effects for the trained limb but also for the contralateral untrained limb. Importantly, the interference effect in the untrained limb was dependent on the level of skill acquisition in the interfering motor task. These behavioural results of the untrained limb were accompanied by training specific changes in corticospinal excitability, which increased for the hemisphere ipsilateral to the trained hand following ballistic training and decreased during accuracy training of the ipsilateral hand. The results demonstrate that contralateral interference effects may occur, and that interference depends on the level of skill acquisition in the interfering motor task. This finding might be particularly relevant for rehabilitation.

  2. Application of RNA interference for the control of female reproductive functions.

    Science.gov (United States)

    Sirotkin, Alexander V

    2012-01-01

    RNA interference, a recently discovered new mechanism controlling gene expression via small RNAs, was shown to be involved in the characterization and control of basic ovarian cell functions. The main classes of small RNAs, as well as their expression in ovaries have been described. Furthermore, the successful application of RNA interference for the study and control of basic ovarian functions (fertility, proliferation, apoptosis, secretory activity, luteogenesis, oocyte maturation and related ovarian cell malignant transformation) and production of recombinant proteins has been demonstrated. Application of RNA interference in reproductive biology and medicine can be successful in three main areas - (1) characterization and prediction of physiological and pathological state (association between particular small RNA and physiological or pathological processes), (2) application of small RNAs for regulation of reproductive processes and (3) treatment of reproductive disorders or their particular indexes. Problems of improvement of small RNA delivery to target ovarian cells and potent RNA interference-related approaches for the treatment of ovarian disorders (especially of ovarian cancer) have been discussed.

  3. Native Language Interference : A study of interference patterns in Swedish students' English writing

    OpenAIRE

    Skoog, Petra

    2006-01-01

    Abstract Titel: Native Language Interference: A study of interference patterns in Swedish students’ English writing. Författare: Skoog, Petra Engelska C, 2006 Abstract: The purpose of this investigation was to find out if there are any patterns of native language interference in Swedish students’ written English. Extensive research has been carried out in the area of native language influence on the target language and a large number of terms are used when the influence of the native language...

  4. Outage analysis of interference-limited systems using STBC with co-channel MIMO interferers

    Institute of Scientific and Technical Information of China (English)

    Yongzhao LI; Leonard J.CIMINI,JR.; Nageen HIMAYAT

    2009-01-01

    The performance of Space-Time Block Coding (STBC) with co-channel MIMO interference is investigated.For an interference-limited environment, the closed-form ex-pressions for the probability density functions of the signal-to-interference ratio are derived and applied to analyze the outage probability with three typical types of co-channel MIMO interferers: STBC, open-loop spatial multiplexing and closed-loop spatial multiplexing. Both theoretical anal-yses and simulation results show that the performance of STBC is independent of the MIMO modes used in the in-terfering links.

  5. A virtual optical probe based on evanescent wave interference

    Institute of Scientific and Technical Information of China (English)

    孙利群; 王佳; 洪涛; 田芊

    2002-01-01

    A virtual probe is a novel immaterial tip based on the near-field evanescent wave interference and small aperture diffraction, which can be used in near-field high-density optical data storage, nano-lithography, near-field optical imaging and spectral detection, near-field optical manipulation of nano-scale specimen, etc. In this paper, the formation mechanism of the virtual probe is analysed, the evanescent wave interference discussed theoretically, andthe sidelobe suppression by small aperture is simulated by the three-dimensional finite-difference time-domain method The simulation results of the optical distribution of the near-field virtual probe reveal that the transmission efficiencyof the virtual probe is 102-104 times higher than that of the nano-aperture metal-coated fibre probe widely used in near-field optical systems. The full width at half maximum of the peak, in other words, the size of virtual probe, is constant whatever the distance in a certain range so that the critical nano-separation control in the near-field system can be relaxed. We give an example of the application of the virtual probe in ultrahigh-density optical data storage.

  6. Regulation of Human Adenovirus Replication by RNA Interference.

    Science.gov (United States)

    Nikitenko, N A; Speiseder, T; Lam, E; Rubtsov, P M; Tonaeva, Kh D; Borzenok, S A; Dobner, T; Prassolov, V S

    2015-01-01

    Adenoviruses cause a wide variety of human infectious diseases. Adenoviral conjunctivitis and epidemic keratoconjunctivitis are commonly associated with human species D adenoviruses. Currently, there is no sufficient or appropriate treatment to counteract these adenovirus infections. Thus, there is an urgent need for new etiology-directed therapies with selective activity against human adenoviruses. To address this problem, the adenoviral early genes E1A and E2B (viral DNA polymerase) seem to be promising targets. Here, we propose an effective approach to downregulate the replication of human species D adenoviruses by means of RNA interference. We generated E1A expressing model cell lines enabling fast evaluation of the RNA interference potential. Small interfering RNAs complementary to the E1A mRNA sequences of human species D adenoviruses mediate significant suppression of the E1A expression in model cells. Furthermore, we observed a strong downregulation of replication of human adenoviruses type D8 and D37 by small hairpin RNAs complementary to the E1A or E2B mRNA sequences in primary human limbal cells. We believe that our results will contribute to the development of efficient anti-adenoviral therapy.

  7. REFIM: A Practical Interference Management in Heterogeneous Wireless Access Networks

    CERN Document Server

    Son, Kyuho; Yi, Yung; Chong, Song

    2011-01-01

    Due to the increasing demand of capacity in wireless cellular networks, the small cells such as pico and femto cells are becoming more popular to enjoy a spatial reuse gain, and thus cells with different sizes are expected to coexist in a complex manner. In such a heterogeneous environment, the role of interference management (IM) becomes of more importance, but technical challenges also increase, since the number of cell-edge users, suffering from severe interference from the neighboring cells, will naturally grow. In order to overcome low performance and/or high complexity of existing static and other dynamic IM algorithms, we propose a novel low-complex and fully distributed IM scheme, called REFIM, in the downlink of heterogeneous multi-cell networks. We first formulate a general optimization problem that turns out to require intractable computation complexity for global optimality. To have a practical solution with low computational and signaling overhead, which is crucial for low-cost small-cell solutio...

  8. The research of the precoding matrices of interference alignment

    Science.gov (United States)

    Du, Yuelin; Xue, Jiang

    2017-01-01

    In recent years, with the rapid development of wireless communication industry, how to manage the interference become a central problem in modern communication system. Actually, this problem mostly comes from the less and less spectrum resource and increasing demand for high data rates. Although many interference management techniques have been proposed, because the interference can exist in any part of wireless communication, some basic problems of network interference are not able to be solved until the emergence of interference alignment technology. Interference alignment, in theory, can enable a performance that all the interference signals fall into the subspace of interference and all the useful signal also fall into the corresponding subspace. In this paper, we focus on the problem of signal transmitted over an interference channel, along the lines of the recently proposed methods of interference alignment. From the basic principle of interference alignment, we can see each receiver maintains its corresponding subspace, the transmitters mold their transmissions regularly in order to make all the interference signal received by a particular receiver and then falls into its interference subspace. The remaining part of the receiver space can be used to get the useful signal. For the general interference channel, compared with the previous method, this kind of technique not only minimizes the interference power that is overflowed out the interference subspace, but also minimizes the power of useful signal that is fell into the interference subspace.

  9. Autobiographical thinking interferes with episodic memory consolidation.

    Directory of Open Access Journals (Sweden)

    Michael Craig

    Full Text Available New episodic memories are retained better if learning is followed by a few minutes of wakeful rest than by the encoding of novel external information. Novel encoding is said to interfere with the consolidation of recently acquired episodic memories. Here we report four experiments in which we examined whether autobiographical thinking, i.e. an 'internal' memory activity, also interferes with episodic memory consolidation. Participants were presented with three wordlists consisting of common nouns; one list was followed by wakeful rest, one by novel picture encoding and one by autobiographical retrieval/future imagination, cued by concrete sounds. Both novel encoding and autobiographical retrieval/future imagination lowered wordlist retention significantly. Follow-up experiments demonstrated that the interference by our cued autobiographical retrieval/future imagination delay condition could not be accounted for by the sound cues alone or by executive retrieval processes. Moreover, our results demonstrated evidence of a temporal gradient of interference across experiments. Thus, we propose that rich autobiographical retrieval/future imagination hampers the consolidation of recently acquired episodic memories and that such interference is particularly likely in the presence of external concrete cues.

  10. General Quantum Interference Principle and Duality Computer

    Institute of Scientific and Technical Information of China (English)

    LONG Gui-Lu

    2006-01-01

    In this article, we propose a general principle of quantum interference for quantum system, and based on this we propose a new type of computing machine, the duality computer, that may outperform in principle both classical computer and the quantum computer. According to the general principle of quantum interference, the very essence of quantum interference is the interference of thesub-waves of the quantum system itself. A quantum system considered here can be any quantum system: a single microscopic particle, a composite quantum system such as an atom or a molecule, or a loose collection of a few quantum objects such as two independent photons. In the duality computer,the wave of the duality computer is split into several sub-waves and they pass through different routes, where different computing gate operations are performed. These sub-waves are then re-combined to interfere to give the computational results. The quantum computer, however, has only used the particle nature of quantum object. In a duality computer,it may be possible to find a marked item from an unsorted database using only a single query, and all NP-complete problems may have polynomial algorithms. Two proof-of-the-principle designs of the duality computer are presented:the giant molecule scheme and the nonlinear quantum optics scheme. We also propose thought experiment to check the related fundamental issues, the measurement efficiency of a partial wave function.

  11. Disentangling posterror and postconflict reduction of interference.

    Science.gov (United States)

    Van der Borght, Liesbet; Braem, Senne; Notebaert, Wim

    2014-12-01

    Conflict monitoring theory (CMT; Botvinick, Braver, Barch, Carter, & Cohen Psychological Review, 108, 624-652, 2001) states that response conflict, the simultaneous activation of two competing responses, increases task focus and reduces interference from irrelevant information. CMT also defines errors as conflict, and reduced interference effects have consistently been reported following errors (Ridderinkhof Psychological Research, 66, 312-323, 2002). However, previous computations of this posterror reduction of interference (PERI) have overlooked the congruency of the previous trial. This is problematic, because most errors are made on incongruent trials, creating a confound between (previous) accuracy and (previous) congruency. Therefore, it is likely that reduced interference following errors is in fact the congruency sequence effect (i.e., reduced interference following incongruent, relative to congruent, trials). Our results corroborate this idea by demonstrating that participants indeed showed significant PERI following a congruent trial, but inverse PERI following an incongruent trial. These findings are discussed in light of the adaptation-by-binding account (Verguts & Notebaert Psychological Review, 115, 518-525, 2008, Trends in Cognitive Sciences, 13, 252-257, 2009).

  12. Epulis and pyogenic granuloma with occlusal interference

    Directory of Open Access Journals (Sweden)

    Widowati Witjaksono

    2005-06-01

    Full Text Available In dental clinic of Hospital University Science Malaysia (HUSM, there were cases with Localized Gingival Enlargement (LGE in the oral cavity with occlusal interference. In this study, three cases were observed. They were a 13 - year- old female with fibrous lge around 31 and 32 with occlusal interference in protrusive movement due to X bite, a 15 - year – old female with pyogenic granuloma near 11 & 21 with occlusal interference due to deep bite; and a 24 – year – old female who was eight months in pregnancy with pyogenic granuloma on the 34-35 and severe generalized pregnancy gingivitis with occlusal interference in centric occlusion and lateral movement. Clinical and histopathological diagnosis of the first case showed fibrous epulis, whereas the second and third cases disclosed pyogenic granuloma. Chronic trauma of the gingiva due to occlusal interference was assumed to be the cause of those LGE in case 1 and 2, while in case 3 poor oral hygiene and chronic trauma were assumed to be the etiologic factors.

  13. Interference effects and phase sensitivity in hearing.

    Science.gov (United States)

    Moore, Brian C J

    2002-05-15

    This paper reviews interference effects in the auditory system, particularly effects occurring in the outer ear and the inner ear (cochlea). Sounds enter the ear canal both directly and after reflections from the pinna. This results in complex spectral patterns, which vary systematically with the direction of incidence of the sound source relative to the head. Evidence is described indicating that these spectral patterns are used in the localization of sounds in space. The cochlea behaves like a limited-resolution frequency analyser. When the components of a complex sound are closely spaced in frequency, they can interfere on the basilar membrane (BM) within the cochlea. Interference effects on the BM are complex, as they are influenced by a physiologically active mechanism which introduces strong nonlinearities, including level-dependent amplification. Interference effects on the BM play a role in many aspects of auditory perception, including the perception of consonance and dissonance, the perception of pitch, the perception of changes in phase, and the perception of timbre. Interference effects in the cochlea may also play a role in producing the spectral regularity observed in sounds reflected from the ear (otoacoustic emissions).

  14. Medial Amygdala Lesions in Male Rats Reduce Aggressive Behavior : Interference With Experience

    NARCIS (Netherlands)

    Vochteloo, J.D.; Koolhaas, J.M.

    1987-01-01

    The medial nucleus of the amygdala (am) has been implicated in a variety of social behaviors. The present experiment will test the hypothesis that the effect of am lesions on intermale aggressive behavior is due to interference with social learning processes. Small electrolytic lesions of the am had

  15. A Simple Laboratory Practical to Illustrate RNA Mediated Gene Interference Using Drosophila Cell Culture

    Science.gov (United States)

    Buluwela, Laki; Kamalati, Tahereh; Photiou, Andy; Heathcote, Dean A.; Jones, Michael D.; Ali, Simak

    2010-01-01

    RNA mediated gene interference (RNAi) is now a key tool in eukaryotic cell and molecular biology research. This article describes a five session laboratory practical, spread over a seven day period, to introduce and illustrate the technique. During the exercise, students working in small groups purify PCR products that encode "in vitro"…

  16. Delaying Interference Training Has Equivalent Effects in Various Pavlovian Interference Paradigms

    Science.gov (United States)

    Powell, Elizabeth J.; Escobar, Martha; Kimble, Whitney

    2013-01-01

    Spontaneous recovery in extinction appears to be inversely related to the acquisition-to-extinction interval, but it remains unclear why this is the case. Rat subjects trained with one of three interference paradigms exhibited less spontaneous recovery of the original response after delayed than immediate interference, regardless of whether…

  17. Experimental Characterization of Close-Emitter Interference in an Optical Camera Communication System

    Science.gov (United States)

    Chavez-Burbano, Patricia; Rabadan, Jose; Perez-Jimenez, Rafael

    2017-01-01

    Due to the massive insertion of embedded cameras in a wide variety of devices and the generalized use of LED lamps, Optical Camera Communication (OCC) has been proposed as a practical solution for future Internet of Things (IoT) and smart cities applications. Influence of mobility, weather conditions, solar radiation interference, and external light sources over Visible Light Communication (VLC) schemes have been addressed in previous works. Some authors have studied the spatial intersymbol interference from close emitters within an OCC system; however, it has not been characterized or measured in function of the different transmitted wavelengths. In this work, this interference has been experimentally characterized and the Normalized Power Signal to Interference Ratio (NPSIR) for easily determining the interference in other implementations, independently of the selected system devices, has been also proposed. A set of experiments in a darkroom, working with RGB multi-LED transmitters and a general purpose camera, were performed in order to obtain the NPSIR values and to validate the deduced equations for 2D pixel representation of real distances. These parameters were used in the simulation of a wireless sensor network scenario in a small office, where the Bit Error Rate (BER) of the communication link was calculated. The experiments show that the interference of other close emitters in terms of the distance and the used wavelength can be easily determined with the NPSIR. Finally, the simulation validates the applicability of the deduced equations for scaling the initial results into real scenarios. PMID:28677613

  18. Reading Ability Is Negatively Related to Stroop Interference

    Science.gov (United States)

    Protopapas, Athanassios; Archonti, Anastasia; Skaloumbakas, Christos

    2007-01-01

    Stroop interference is often taken as evidence for reading automaticity even though young and poor readers, who presumably lack reading automaticity, present strong interference. Here the relationship between reading skills and Stroop interference was studied in a 7th-grade sample. Greater interference was observed in children diagnosed with…

  19. Interference Calculus A General Framework for Interference Management and Network Utility Optimization

    CERN Document Server

    Schubert, Martin

    2012-01-01

    This book develops a mathematical framework for modeling and optimizing interference-coupled multiuser systems. At the core of this framework is the concept of general interference functions, which provides a simple means of characterizing interdependencies between users. The entire analysis builds on the two core axioms scale-invariance and monotonicity. The proposed network calculus has its roots in power control theory and wireless communications. It adds theoretical tools for analyzing the typical behavior of interference-coupled networks. In this way it complements existing game-theoretic approaches. The framework should also be viewed in conjunction with optimization theory. There is a fruitful interplay between the theory of interference functions and convex optimization theory. By jointly exploiting the properties of interference functions, it is possible to design algorithms that outperform general-purpose techniques that only exploit convexity. The title “network calculus” refers to the fact tha...

  20. Collisional quantum interference on rotational energy transfer: physical interpretation of the differential interference angle

    Institute of Scientific and Technical Information of China (English)

    Li Yong-Qing; Li Jian; Ma Feng-Cai

    2006-01-01

    Collisional quantum interference (CQI) on the intramolecular rotational energy transfer is observed in an experiment with a static cell, and the integral interference angles are measured. To obtain more accurate information, an experiment with a molecular beam is carried out, and thereby the relationship between the differential interference angle and the scattering angle is obtained. Based on the first-Born approximation of time-dependent perturbation theory,the theoretical model of CQI is developed in an atom-diatom system in the condition of the molecular beam, with the long-range interaction potential taken into account. The method of measuring correctly the differential interference angle is presented. The tendencies of the differential interference angle changing with the impact parameter and relative velocity are discussed. The theoretical model presented here is important for understanding or performing the experiment in the molecular beam.

  1. Communication in a Poisson Field of Interferers -- Part I: Interference Distribution and Error Probability

    CERN Document Server

    Pinto, Pedro C

    2010-01-01

    We present a mathematical model for communication subject to both network interference and noise. We introduce a framework where the interferers are scattered according to a spatial Poisson process, and are operating asynchronously in a wireless environment subject to path loss, shadowing, and multipath fading. We consider both cases of slow and fast-varying interferer positions. The paper is comprised of two separate parts. In Part I, we determine the distribution of the aggregate network interference at the output of a linear receiver. We characterize the error performance of the link, in terms of average and outage probabilities. The proposed model is valid for any linear modulation scheme (e.g., M-ary phase shift keying or M-ary quadrature amplitude modulation), and captures all the essential physical parameters that affect network interference. Our work generalizes the conventional analysis of communication in the presence of additive white Gaussian noise and fast fading, allowing the traditional results...

  2. On Interference of Chinese with ELL

    Institute of Scientific and Technical Information of China (English)

    九曼

    2011-01-01

    It is popularly admitted that the foreign language learning is strongly influenced by learners' first language.Generally speaking,the interference of Chinese with ELL is divided into negative transfer and positive transfer,which are manifested at various levels during ELL.The thesis aims to show the interference of Chinese with ELL,with the approach of qualitative analysis,the paper is arranged into Part Ⅰ:Introduction; Part Ⅱ:The Contrast between ELL and Chinese Language Acquisition; Part Ⅲ:The Influence of Chinese on ELL:Part Ⅵ:Conclusion.Being aware of the interference of Chinese with ELL will help students overcome the obstacles and promote ELL.

  3. Non-classical paths in interference experiments

    CERN Document Server

    Sawant, Rahul; Sinha, Aninda; Sinha, Supurna; Sinha, Urbasi

    2014-01-01

    In a double slit interference experiment, the wave function at the screen with both slits open is not exactly equal to the sum of the wave functions with the slits individually open one at a time. The three scenarios represent three different boundary conditions and as such, the superposition principle should not be applicable. However, most well known text books in quantum mechanics implicitly and/or explicitly use this assumption which is only approximately true. In our present study, we have used the Feynman path integral formalism to quantify contributions from non-classical paths in quantum interference experiments which provide a measurable deviation from a naive application of the superposition principle. A direct experimental demonstration for the existence of these non-classical paths is hard. We find that contributions from such paths can be significant and we propose simple three-slit interference experiments to directly confirm their existence.

  4. Nonclassical Paths in Quantum Interference Experiments

    Science.gov (United States)

    Sawant, Rahul; Samuel, Joseph; Sinha, Aninda; Sinha, Supurna; Sinha, Urbasi

    2014-09-01

    In a double slit interference experiment, the wave function at the screen with both slits open is not exactly equal to the sum of the wave functions with the slits individually open one at a time. The three scenarios represent three different boundary conditions and as such, the superposition principle should not be applicable. However, most well-known text books in quantum mechanics implicitly and/or explicitly use this assumption that is only approximately true. In our present study, we have used the Feynman path integral formalism to quantify contributions from nonclassical paths in quantum interference experiments that provide a measurable deviation from a naive application of the superposition principle. A direct experimental demonstration for the existence of these nonclassical paths is difficult to present. We find that contributions from such paths can be significant and we propose simple three-slit interference experiments to directly confirm their existence.

  5. Electromagnetic Interference on Large Wind Turbines

    Directory of Open Access Journals (Sweden)

    Florian Krug

    2009-11-01

    Full Text Available Electromagnetic interference (EMI can both affect and be transmitted by mega-watt wind turbines. This paper provides a general overview on EMI with respect to mega-watt wind turbines. Possibilities of measuring all types of electromagnetic interference are shown. Electromagnetic fields resulting from a GSM transmitter mounted on a mega-watt wind turbine will be analyzed in detail. This cellular system operates as a real-time communication link. The method-of-moments is used to analytically describe the electro-magnetic fields. The electromagnetic interference will be analyzed under the given boundary condition with a commercial simulation tool. Different transmitter positions are judged on the basis of their radiation patterns. The principal EMI mechanisms are described and taken into consideration.

  6. Cross-limb Interference during motor learning

    DEFF Research Database (Denmark)

    Lauber, Benedikt; Jensen, Jesper Lundbye; Keller, Martin;

    2013-01-01

    the training, after the training and in an immediate retention test after the practice of the interference task for both the trained and the untrained hand. After training, subjects showed not only significant learning and interference effects for the trained limb but also for the contralateral untrained limb......It is well known that following skill learning, improvements in motor performance may transfer to the untrained contralateral limb. It is also well known that retention of a newly learned task A can be degraded when learning a competing task B that takes place directly after learning A. Here we...... investigate if this interference effect can also be observed in the limb contralateral to the trained one. Therefore, five different groups practiced a ballistic finger flexion task followed by an interfering visuomotor accuracy task with the same limb. Performance in the ballistic task was tested before...

  7. Gravitational and rotational effects in quantum interference

    Energy Technology Data Exchange (ETDEWEB)

    Anandan, J.

    1977-03-15

    The phase shift due to gravitation and rotation in the quantum interference of two coherent beams is obtained relativistically and compared with the recent experiment of Colella, Overhauser, and Werner. A general expression relating the quantum phase shift to the transverse acceleration of a classical particle in the plane of interference for an arbitrary interaction with any external field is given. This can serve as a correspondence principle between quantum physics and classical physics. The phase shift due to the coupling of spin to curvature of space-time is deduced and written explicitly for the special case of a Schwarzschild field. The last result implies that a massless spinning particle can have at most two helicity states and its world line in a gravitational field is a null geodesic. Finally, new experiments are proposed to test the effect of rotation on quantum interference and to obtain direct evidence of the equivalence principle in quantum mechanics.

  8. Transverse relativistic effects in paraxial wave interference

    CERN Document Server

    Bliokh, Konstantin Y; Nori, Franco

    2013-01-01

    We consider relativistic deformations of interfering paraxial waves moving in the transverse direction. Owing to superluminal transverse phase velocities, noticeable deformations of the interference patterns arise when the waves move with respect to each other with non-relativistic velocities. Similar distortions also appear on a mutual tilt of the interfering waves, which causes a phase delay analogous to the relativistic time delay. We illustrate these observations by the interference between a vortex wave beam and a plane wave, which exhibits a pronounced deformation of the radial fringes into a fork-like pattern (relativistic Hall effect). Furthermore, we describe an additional relativistic motion of the interference fringes (a counter-rotation in the vortex case), which become noticeable at the same non-relativistic velocities.

  9. Spiral holographic imaging through quantum interference

    Science.gov (United States)

    Tang, Jie; Ming, Yang; Hu, Wei; Lu, Yan-qing

    2017-07-01

    Spiral holographic imaging in the Hong-Ou-Mandel interference scheme is introduced. Using spontaneous parametric down-conversion as a source of photon pairs, we analyze the joint orbital angular momentum spectrum of a reference photon and the photon encoding information of the object. The first-order interference of light beams in standard holographic imaging is replaced by the quantum interference of two-photon probability amplitudes. The difficulty in retrieving the amplitude and phase structure of an unknown photon is thereby avoided as classical interferometric techniques such as optical holography do not apply. Our results show that the full information of the object's transmission function can be recorded in the spiral hologram, which originates directly from the joint orbital angular momentum spectrum. This presents a lateral demonstration of compressive imaging and can potentially be used for remote sensing.

  10. Multichannel interference mitigation methods in radio astronomy

    CERN Document Server

    Leshem, A; Boonstra, A J; Leshem, Amir; Veen, Alle-Jan van der; Boonstra, Albert-Jan

    2000-01-01

    Radio-astronomical observations are increasingly corrupted by RF interference, and online detection and filtering algorithms are becoming essential. To facilitate the introduction of such techniques into radio astronomy, we formulate the astronomical problem in an array signal processing language, and give an introduction to some elementary algorithms from that field. We consider two topics in detail: interference detection by rank estimation of short-term covariance matrices, and spatial filtering by subspace estimation and projection. We discuss experimental data collected at the Westerbork radio telescope, and illustrate the effectiveness of the space-time detection and blanking process on the recovery of a 3C48 absorption line in the presence of GSM mobile telephony interference.

  11. Proactive interference effects on sentence production

    Science.gov (United States)

    FERREIRA, VICTOR S.; FIRATO, CARLA E.

    2007-01-01

    Proactive interference refers to recall difficulties caused by prior similar memory-related processing. Information-processing approaches to sentence production predict that retrievability affects sentence form: Speakers may word sentences so that material that is difficult to retrieve is spoken later. In this experiment, speakers produced sentence structures that could include an optional that, thereby delaying the mention of a subsequent noun phrase. This subsequent noun phrase was either (1) conceptually similar to three previous noun phrases in the same sentence, leading to greater proactive interference, or (2) conceptually dissimilar, leading to less proactive interference. Speakers produced more thats (and were more disfluencies) before conceptually similar noun phrases, suggesting that retrieval difficulties during sentence production affect the syntactic structures of sentences that speakers produce. PMID:12613685

  12. Hybrid Access Femtocells in Overlaid MIMO Cellular Networks with Transmit Selection under Poisson Field Interference

    KAUST Repository

    Abdel Nabi, Amr A

    2017-09-21

    This paper analyzes the performance of hybrid control-access schemes for small cells (such as femtocells) in the context of two-tier overlaid cellular networks. The proposed hybrid access schemes allow for sharing the same downlink resources between the small-cell network and the original macrocell network, and their mode of operations are characterized considering post-processed signal-to-interference-plus-noise ratios (SINRs) or pre-processed interference-aware operation. The work presents a detailed treatment of achieved performance of a desired user that benefits from MIMO arrays configuration through the use of transmit antenna selection (TAS) and maximal ratio combining (MRC) in the presence of Poisson field interference processes on spatial links. Furthermore, based on the interference awareness at the desired user, two TAS approaches are treated, which are the signal-to-noise (SNR)-based selection and SINR-based selection. The analysis is generalized to address the cases of highly-correlated and un-correlated aggregated interference on different transmit channels. In addition, the effect of delayed TAS due to imperfect feedback and the impact of arbitrary TAS processing are investigated. The analytical results are validated by simulations, to clarify some of the main outcomes herein.

  13. Staphylococcal pathogenicity island interference with helper phage reproduction is a paradigm of molecular parasitism.

    Science.gov (United States)

    Ram, Geeta; Chen, John; Kumar, Krishan; Ross, Hope F; Ubeda, Carles; Damle, Priyadarshan K; Lane, Kristin D; Penadés, José R; Christie, Gail E; Novick, Richard P

    2012-10-02

    Staphylococcal pathogenicity islands (SaPIs) carry superantigen and resistance genes and are extremely widespread in Staphylococcus aureus and in other Gram-positive bacteria. SaPIs represent a major source of intrageneric horizontal gene transfer and a stealth conduit for intergeneric gene transfer; they are phage satellites that exploit the life cycle of their temperate helper phages with elegant precision to enable their rapid replication and promiscuous spread. SaPIs also interfere with helper phage reproduction, blocking plaque formation, sharply reducing burst size and enhancing the survival of host cells following phage infection. Here, we show that SaPIs use several different strategies for phage interference, presumably the result of convergent evolution. One strategy, not described previously in the bacteriophage microcosm, involves a SaPI-encoded protein that directly and specifically interferes with phage DNA packaging by blocking the phage terminase small subunit. Another strategy involves interference with phage reproduction by diversion of the vast majority of virion proteins to the formation of SaPI-specific small infectious particles. Several SaPIs use both of these strategies, and at least one uses neither but possesses a third. Our studies illuminate a key feature of the evolutionary strategy of these mobile genetic elements, in addition to their carriage of important genes-interference with helper phage reproduction, which could ensure their transferability and long-term persistence.

  14. Frequent video game players resist perceptual interference.

    Directory of Open Access Journals (Sweden)

    Aaron V Berard

    Full Text Available Playing certain types of video games for a long time can improve a wide range of mental processes, from visual acuity to cognitive control. Frequent gamers have also displayed generalized improvements in perceptual learning. In the Texture Discrimination Task (TDT, a widely used perceptual learning paradigm, participants report the orientation of a target embedded in a field of lines and demonstrate robust over-night improvement. However, changing the orientation of the background lines midway through TDT training interferes with overnight improvements in overall performance on TDT. Interestingly, prior research has suggested that this effect will not occur if a one-hour break is allowed in between the changes. These results have suggested that after training is over, it may take some time for learning to become stabilized and resilient against interference. Here, we tested whether frequent gamers have faster stabilization of perceptual learning compared to non-gamers and examined the effect of daily video game playing on interference of training of TDT with one background orientation on perceptual learning of TDT with a different background orientation. As a result, we found that non-gamers showed overnight performance improvement only on one background orientation, replicating previous results with the interference in TDT. In contrast, frequent gamers demonstrated overnight improvements in performance with both background orientations, suggesting that they are better able to overcome interference in perceptual learning. This resistance to interference suggests that video game playing not only enhances the amplitude and speed of perceptual learning but also leads to faster and/or more robust stabilization of perceptual learning.

  15. Carbon nanostructure composite for electromagnetic interference shielding

    Indian Academy of Sciences (India)

    Anupama Joshi; Suwarna Datar

    2015-06-01

    This communication reviews current developments in carbon nanostructure-based composite materials for electromagnetic interference (EMI) shielding. With more and more electronic gadgets being used at different frequencies, there is a need for shielding them from one another to avoid interference. Conventionally, metal-based shielding materials have been used. But due to the requirement of light weight, corrosion resistive materials, lot of work is being done on composite materials. In this research the forerunner is the nanocarbon-based composite material whose different forms add different characteristics to the composite. The article focusses on composites based on graphene, graphene oxide, carbon nanotubes, and several other novel forms of carbon.

  16. LANGUAGE AND CULTURE INTERFERENCE IN PLURILINGUAL EDUCATION

    Directory of Open Access Journals (Sweden)

    Hackett-Jones, A.V.

    2016-09-01

    Full Text Available The article deals with interlingual phenomena that occur in the process of multiple language acquisition in a learning environment. The notions of language interference and transfer put forward by the theories of bilingualism, give useful insights when applied to the modern day educational trends. Language and culture interference is an important aspect to be considered with regard to teaching of plurilingual learners, whose communicative competence is formed on the basis of several linguistic and cultural systems that interact with each other and exert mutual influence.

  17. Interference of electromagnetic waves in dynamic metabolism

    Institute of Scientific and Technical Information of China (English)

    黄卡玛; 唐敬贤; 刘永清; 徐兰

    1995-01-01

    Life is a continuous process of the dynamic metabolism.The influence of electromagneticwaves on the process of metabolism cannot be neglected.Here a new theory of electromagnetic interference inthe dynamic metabolism of life is proposed.The statistical dynamic equations of ion and free radical in thebiochemical reaction radiated by electromagnetic waves are given.The intensity of electromagnetic interferencecould be described with an interference factor.Good agreement can be seen between the calculated and meas-ured results for a famous experiment of radio-frequency radiation-induced calcium ion efflux enhancement.

  18. Neutrino tridents and W - Z interference

    Energy Technology Data Exchange (ETDEWEB)

    Mishra, S.R.; Rabinowitz, S.A.; Arroyo, C.; Bachmann, K.T.; Blair, R.E.; Foudas, C.; King, B.J.; Lefmann, W.C.; Leung, W.C.; Oltman, E.; Quintas, P.Z.; Sciulli, F.J.; Seligman, B.G.; Shaevitz, M.H. (Columbia University, New York, New York 10027 (USA)); Merritt, F.S.; Oreglia, M.J.; Schumm, B.A. (University of Chicago, Chicago, Illinois 60637 (USA)); Bernstein, R.H.; Borcherding, F.; Fisk, H.E.; Lamm, M.J.; Marsh, W.; Merritt, K.W.B.; Schellman, H.; Yovanovitch, D.D. (Fermilab, Batavia, Illinois 60510 (USA)); Bodek, A.; Budd, H.S.; de Barbaro, P.; Sakumoto, W.K. (University of Rochester, Rochester, New York 14627 (USA)); Sandler, P.H.; Smith, W.H. (University of Wisconsin, Madison, Wisconsin 53706 (USA))

    1991-06-17

    We present a measurement of neutrino tridents, muon pairs induced by neutrino scattering in the Coulomb field of a target nucleus, in the Columbia-Chicago-Fermilab-Rochester neutrino experiment at the Fermilab Tevatron. The observed number of tridents after geometric and kinematic corrections, 37.0{plus minus}12.4, supports the standard-model prediction of 45.3{plus minus}2.3 events. This is the first demonstration of the {ital W}-{ital Z} destructive interference from neutrino tridents, and rules out, at 99% C.L., the {ital V}-{ital A} prediction without the interference.

  19. Cardiovascular RNA interference therapy: the broadening tool and target spectrum.

    Science.gov (United States)

    Poller, Wolfgang; Tank, Juliane; Skurk, Carsten; Gast, Martina

    2013-08-16

    Understanding of the roles of noncoding RNAs (ncRNAs) within complex organisms has fundamentally changed. It is increasingly possible to use ncRNAs as diagnostic and therapeutic tools in medicine. Regarding disease pathogenesis, it has become evident that confinement to the analysis of protein-coding regions of the human genome is insufficient because ncRNA variants have been associated with important human diseases. Thus, inclusion of noncoding genomic elements in pathogenetic studies and their consideration as therapeutic targets is warranted. We consider aspects of the evolutionary and discovery history of ncRNAs, as far as they are relevant for the identification and selection of ncRNAs with likely therapeutic potential. Novel therapeutic strategies are based on ncRNAs, and we discuss here RNA interference as a highly versatile tool for gene silencing. RNA interference-mediating RNAs are small, but only parts of a far larger spectrum encompassing ncRNAs up to many kilobasepairs in size. We discuss therapeutic options in cardiovascular medicine offered by ncRNAs and key issues to be solved before clinical translation. Convergence of multiple technical advances is highlighted as a prerequisite for the translational progress achieved in recent years. Regarding safety, we review properties of RNA therapeutics, which may immunologically distinguish them from their endogenous counterparts, all of which underwent sophisticated evolutionary adaptation to specific biological contexts. Although our understanding of the noncoding human genome is only fragmentary to date, it is already feasible to develop RNA interference against a rapidly broadening spectrum of therapeutic targets and to translate this to the clinical setting under certain restrictions.

  20. 小分子干扰RNA抑制高氧暴露下人肺腺癌A549细胞中的硫氧还蛋白-2对还原型烟酰胺腺嘌呤二核苷酸脱氢酶亚单位1、细胞色素C氧化酶工表达的影响%Suppressed expression of thioredoxin-2 by small interference RNA in A549 cells exposed to hyperoxia reduced expression of nicotinamide-adenine dinucleotide dehydrogenase subunit 1 and cytochrome C oxidase Ⅰ

    Institute of Scientific and Technical Information of China (English)

    蔡成; 常立文; 李文斌; 陈燕; 单瑞艳; 刘伟; 潘睿

    2010-01-01

    Objective To explore the effects of expression of thioredoxin-2(Trx-2) suppressed by small interference RNA(SiRNA) in A549 cells exposed to hyperoxia on expression of nicotinamide adenine dinucleotide(NADH) dehydrogenase subunit 1(ND1)and cytochrome C oxidase Ⅰ(COX Ⅰ). Methods A549 cells were gained by serial subcultivation in vitro and transfered with synthetic Trx-2 sequence-specific SiRNA and then were randomly divided into air group without interference,hyperoxia group without interference,air group after interference,and hyperoxia group after interference.After exposure to oxygen or room air for 12,24 and 48 h,expressions of Trx-2,ND1 and COX Ⅰ mRNA of these cells were detected by reverse transcription-polymerase chain reaction (RT-PCR),and Trx-2 protein was detected by Western blot. Results (1)Sequence-specific SiRNA targeting Trx-2 could significantly down-regulate its expression in A549 cells.(2)Trx-2 mRNA levds in hyperoxia group without interference at 24 h was higher than those in air group without interference(0.7799±0.1249 VS 0.4424±Ⅰ.1140,P<0.05).Th-2 mRNA levels in hyperoxia group after ireedcrence at 24 h and 48 h were 0.2774±0.0174 and 0.2587±0.0069,lower than those in air group after interference and hyperoxia group without interference (P<0.05).(3)ND1 mRNA levels in hyperoxia group without interference at 24 h was 0.6609±0.0368,lower than those in air group without interference(0.8898±0.1049)(P<0.05).ND1 mRNA levels in hyperoxia group after interference at 12 h was 0.8848±0.0135,higher than those in air group after imederence(P<0.05).ND1 mRNA levels in hypemxia group after interference at 48 h was 0.3808±0.0937,lower than those in air group after imerference and hyperoxia group without interference(P<0.05).(4)COXI mRNA levels in hypemxia group without inteference at 12,24 and 48 h were 1.7313±0.4331,2.1929±0.6722 and 2.0754±0.2584,higher than those in air group witheUt interference,respectively (P<0.05). Conclusions ND1 and

  1. 47 CFR 74.703 - Interference.

    Science.gov (United States)

    2010-10-01

    ... due to terrain shielding and/or Longley-Rice terrain dependent propagation methods, the licensee of a... any condition of interference to the direct reception of the signal of any other TV broadcast analog... of a regularly used signal is impaired by the signals radiated by the low power TV, TV translator,...

  2. Engine Power Effects on Support Interference

    NARCIS (Netherlands)

    Horsten, B.J.C.; Veldhuis, L.L.M.

    2009-01-01

    Renewed interest in propeller propulsion on aircraft configurations combined with higher propeller loads lead to the question how the effects of the propulsion on model support disturbances should be accounted for. In this paper, the determination of engine power effects on support interference of s

  3. Wakeful rest alleviates interference-based forgetting.

    Science.gov (United States)

    Mercer, Tom

    2015-01-01

    Retroactive interference (RI)--the disruptive influence of events occurring after the formation of a new memory--is one of the primary causes of forgetting. Placing individuals within an environment that postpones interference should, therefore, greatly reduce the likelihood of information being lost from memory. For example, a short period of wakeful rest should diminish interference-based forgetting. To test this hypothesis, participants took part in a foreign language learning activity and were shown English translations of 20 Icelandic words for immediate recall. Half of the participants were then given an 8-min rest before completing a similar or dissimilar interfering distractor task. The other half did not receive a rest until after the distractor task, at which point interference had already taken place. All participants were then asked to translate the Icelandic words for a second time. Results revealed that retention was significantly worse at the second recall test, but being allowed a brief rest before completing the distractor task helped reduce the amount of forgetting. Taking a short, passive break can shield new memories from RI and alleviate forgetting.

  4. Genetic Diversity in the Interference Selection Limit

    Science.gov (United States)

    Good, Benjamin H.; Walczak, Aleksandra M.; Neher, Richard A.; Desai, Michael M.

    2014-01-01

    Pervasive natural selection can strongly influence observed patterns of genetic variation, but these effects remain poorly understood when multiple selected variants segregate in nearby regions of the genome. Classical population genetics fails to account for interference between linked mutations, which grows increasingly severe as the density of selected polymorphisms increases. Here, we describe a simple limit that emerges when interference is common, in which the fitness effects of individual mutations play a relatively minor role. Instead, similar to models of quantitative genetics, molecular evolution is determined by the variance in fitness within the population, defined over an effectively asexual segment of the genome (a “linkage block”). We exploit this insensitivity in a new “coarse-grained” coalescent framework, which approximates the effects of many weakly selected mutations with a smaller number of strongly selected mutations that create the same variance in fitness. This approximation generates accurate and efficient predictions for silent site variability when interference is common. However, these results suggest that there is reduced power to resolve individual selection pressures when interference is sufficiently widespread, since a broad range of parameters possess nearly identical patterns of silent site variability. PMID:24675740

  5. Simulation Tools Prevent Signal Interference on Spacecraft

    Science.gov (United States)

    2014-01-01

    NASA engineers use simulation software to detect and prevent interference between different radio frequency (RF) systems on a rocket and satellite before launch. To speed up the process, Kennedy Space Center awarded SBIR funding to Champaign, Illinois-based Delcross Technologies LLC, which added a drag-and-drop feature to its commercial simulation software, resulting in less time spent preparing for the analysis.

  6. Movement Interference in Autism-Spectrum Disorder

    Science.gov (United States)

    Gowen, E.; Stanley, J.; Miall, R. C.

    2008-01-01

    Movement interference occurs when concurrently observing and executing incompatible actions and is believed to be due to co-activation of conflicting populations of mirror neurons. It has also been suggested that mirror neurons contribute towards the imitation of observed actions. However, the exact neural substrate of imitation may depend on task…

  7. Preserved Proactive Interference in Autism Spectrum Disorder

    Science.gov (United States)

    Carmo, Joana C.; Duarte, Elsa; Pinho, Sandra; Filipe, Carlos N.; Marques, J. Frederico

    2016-01-01

    In this study, we aimed to evaluate further the functioning and structuring of the semantic system in autism spectrum disorders (ASD). We analyzed the performance of 19 high-functioning young adults with ASD and a group of 20 age-, verbal IQ- and education-matched individuals with the Proactive Interference (PI) Paradigm to evaluate semantic…

  8. Jam-X: Wireless Agreement under Interference

    CERN Document Server

    Boano, Carlo Alberto; Zúñiga, Marco Antonio; Voigt, Thiemo

    2012-01-01

    Wireless low-power transceivers used in sensor networks such as IEEE 802.15.4 typically operate in unlicensed frequency bands that are subject to external interference from devices transmitting at much higher power. Communication protocols should therefore be designed to be robust against such interference. A critical building block of many protocols at all layers is agreement on a piece of information among a set of nodes. At the MAC layer, nodes may need to agree on a new time slot or frequency channel; at the application layer nodes may need to agree on handing over a leader role from one node to another. Message loss caused by interference may break agreement in two different ways: none of the nodes use the new information (time slot, channel, leader) and stick with the previous assignment, or - even worse - some nodes use the new information and some do not. This may lead to reduced performance or failures. In this paper we investigate the problem of agreement under interference and point out the limitat...

  9. Interference enhanced thermoelectricity in quinoid type structures

    NARCIS (Netherlands)

    Strange, M.; Seldenthuis, J.S.; Verzijl, C.J.O.; Thijssen, J.M.; Solomon, G.C.

    2015-01-01

    Quantum interference (QI) effects in molecular junctions may be used to obtain large thermoelectric responses. We study the electrical conductance G and the thermoelectric response of a series of molecules featuring a quinoid core using density functional theory, as well as a semi-empirical

  10. Collectivity from interference arXiv

    CERN Document Server

    Blok, Boris; Strikman, Mark; Wiedemann, Urs Achim

    In hadronic collisions, interference between different production channels affects momentum distributions of multi-particle final states. As this QCD interference does not depend on the strong coupling constant, it is part of the no-interaction baseline that needs to be controlled prior to searching for other manifestations of collective dynamics. Here, we introduce a model that is based on the QCD theory of multi-parton interactions and that allows one to study interference effects in the production of $m$ particles in hadronic collisions with $N$ parton-parton interactions ("sources"). In an expansion in powers of $1/(N_c^2-1)$ and to leading order in the number of sources $N$, we calculate interference effects in the $m$-particle spectra and we determine from them the second and fourth order cumulant momentum anisotropies $v_n$. Without invoking any azimuthal asymmetry and any density dependent non-linear dynamics in the incoming state, and without invoking any interaction in the final state, we find that ...

  11. Phase-Modulation Laser Interference Microscopy

    DEFF Research Database (Denmark)

    Brazhe, Alexey; Brazhe, Nadezda; Maximov, G. V.

    2008-01-01

    We describe how phase-modulation laser interference microscopy and wavelet analysis can be applied to noninvasive nonstained visualization and study of the structural and dynamical properties of living cells. We show how phase images of erythrocytes can reveal the difference between various...

  12. The Acceptability of Speech with Radio Interference

    DEFF Research Database (Denmark)

    Baykaner, K.; Hummersone, H.; Mason, R.

    2014-01-01

    A listening test was conducted to investigate the acceptability of audio-on-audio interference for radio programs featuring speech as the target. Twenty-one subjects, including naïve and expert listeners, were presented with 200 randomly assigned pairs of stimuli and asked to report, for each trial...

  13. Interference subspace rejection in wideband CDMA:

    DEFF Research Database (Denmark)

    Hansen, Henrik; Affes, Sofiene; Mermelstein, Paul

    2001-01-01

    This paper extends our study on a multi-user receiver structure for base-station receivers with antenna arrays in multicellular systems. The receiver employs a beamforming structure with constraints that nulls the signal component in appropriate interference subspaces. Here we introduce a new mod...

  14. Movement Interference in Autism-Spectrum Disorder

    Science.gov (United States)

    Gowen, E.; Stanley, J.; Miall, R. C.

    2008-01-01

    Movement interference occurs when concurrently observing and executing incompatible actions and is believed to be due to co-activation of conflicting populations of mirror neurons. It has also been suggested that mirror neurons contribute towards the imitation of observed actions. However, the exact neural substrate of imitation may depend on task…

  15. Two-order Interference of Single Photon

    Institute of Scientific and Technical Information of China (English)

    JIANG Yunkun; LI Jian; SHI Baosen; FAN Xiaofeng; GUO Guangcan

    2000-01-01

    A pair of photons called signal and idler photons, respectively, are produced through the nonlinear process of type-I spontaneous parametric downconversion in BBO crystal pumped by the second-harmonic wave of a Ti:sapphire femtosecond laser pulse. The two-order interference phenomenon of the signal photon in Michelson interferometer is observed and give an analysis in detail.

  16. The Acceptability of Speech with Radio Interference

    DEFF Research Database (Denmark)

    Baykaner, K.; Hummersone, H.; Mason, R.

    2014-01-01

    A listening test was conducted to investigate the acceptability of audio-on-audio interference for radio programs featuring speech as the target. Twenty-one subjects, including naïve and expert listeners, were presented with 200 randomly assigned pairs of stimuli and asked to report, for each trial...

  17. Nonsurgical management of disc-interference disorders.

    Science.gov (United States)

    Okeson, J P

    1991-01-01

    Disc-interference disorders are a group of intracapsular problems that make up one category of temporomandibular disorders. The dental profession's understanding of these disorders has changed greatly in recent years. This article reviews current concepts regarding the diagnosis and management of these disorders as revealed through recent clinical studies.

  18. Electron Interference in Ballistic Graphene Nanoconstrictions

    DEFF Research Database (Denmark)

    Baringhaus, Jens; Settnes, Mikkel; Aprojanz, Johannes

    2016-01-01

    We realize nanometer size constrictions in ballistic graphene nanoribbons grown on sidewalls of SiC mesa structures. The high quality of our devices allows the observation of a number of electronic quantum interference phenomena. The transmissions of Fabry-Perot-like resonances are probed...

  19. Mitigation of MIMO Co-Channel Interference using robust interference cancellation receiver

    DEFF Research Database (Denmark)

    Rahman, Muhammad Imadur; De Carvalho, Elisabeth; Prasad, Ramjee

    2007-01-01

    (STBC) link may become equivalent to an interfering Spatial Multiplexing (SM) link. Using this knowledge and understanding, we propose an interference cancellation receiver robust to different types of MIMO interferers at cell edge for the Downlink (DL) of cellular systems. The receiver systematically......) statistics and Bit Error Rate (BER) performance in cellular Orthogonal Frequency Division Multiple Access (OFDMA) systems. We have found that the proposed multiple-symbol linear interference cancellation receiver performs satisfactorily when any kind of single 'logical' stream MIMO scheme is present...

  20. Interference effects of categorization on decision making.

    Science.gov (United States)

    Wang, Zheng; Busemeyer, Jerome R

    2016-05-01

    Many decision making tasks in life involve a categorization process, but the effects of categorization on subsequent decision making has rarely been studied. This issue was explored in three experiments (N=721), in which participants were shown a face stimulus on each trial and performed variations of categorization-decision tasks. On C-D trials, they categorized the stimulus and then made an action decision; on X-D trials, they were told the category and then made an action decision; on D-alone trials, they only made an action decision. An interference effect emerged in some of the conditions, such that the probability of an action on the D-alone trials (i.e., when there was no explicit categorization before the decision) differed from the total probability of the same action on the C-D or X-D trials (i.e., when there was explicit categorization before the decision). Interference effects are important because they indicate a violation of the classical law of total probability, which is assumed by many cognitive models. Across all three experiments, a complex pattern of interference effects systematically occurred for different types of stimuli and for different types of categorization-decision tasks. These interference effects present a challenge for traditional cognitive models, such as Markov and signal detection models, but a quantum cognition model, called the belief-action entanglement (BAE) model, predicted that these results could occur. The BAE model employs the quantum principles of superposition and entanglement to explain the psychological mechanisms underlying the puzzling interference effects. The model can be applied to many important and practical categorization-decision situations in life.

  1. Attentional switches and dual-task interference.

    Directory of Open Access Journals (Sweden)

    Janne F Ettwig

    Full Text Available In four experiments, we studied the time course of interference between detection of an oddball orientation target (OT in an 8-item circular search display, and identification of a letter target (LT in a central stream of distractor letters. Dual-task performance for different temporal lags between targets was compared to single-task performance. When the LT preceded the OT, dual-task performance levels were reduced at short inter-target intervals of 0 and 166 ms; when the OT preceded the LT, the dual-task interference was unexpectedly stronger and lasted for up to 500 ms. Resource competition due to temporally overlapping target processing cannot account for this result, because the feature search task is easier than the letter identification task, and therefore would have generated less interference when presented first. Two alternative explanations were explored. First, by manipulating the spatial inter-target distance, we investigated to what degree there is a penalty associated with directing the attentional window from a large object (the search display to a smaller object (the central letter stream. Second, by varying the duration of the OT and subsequent mask, we studied whether the interference was caused by the difficulty of disengaging attention from the search display. Results support this second explanation and thus indicate that switching attention to the letter stream is hampered by the continuing presence of (masked search display items. This result shows that attentional effects may play a major role in dual-task execution and can easily obscure interference due to other factors such as resource competition.

  2. A Comparative Study of Co-Channel Interference Suppression Techniques

    Science.gov (United States)

    Hamkins, Jon; Satorius, Ed; Paparisto, Gent; Polydoros, Andreas

    1997-01-01

    We describe three methods of combatting co-channel interference (CCI): a cross-coupled phase-locked loop (CCPLL); a phase-tracking circuit (PTC), and joint Viterbi estimation based on the maximum likelihood principle. In the case of co-channel FM-modulated voice signals, the CCPLL and PTC methods typically outperform the maximum likelihood estimators when the modulation parameters are dissimilar. However, as the modulation parameters become identical, joint Viterbi estimation provides for a more robust estimate of the co-channel signals and does not suffer as much from "signal switching" which especially plagues the CCPLL approach. Good performance for the PTC requires both dissimilar modulation parameters and a priori knowledge of the co-channel signal amplitudes. The CCPLL and joint Viterbi estimators, on the other hand, incorporate accurate amplitude estimates. In addition, application of the joint Viterbi algorithm to demodulating co-channel digital (BPSK) signals in a multipath environment is also discussed. It is shown in this case that if the interference is sufficiently small, a single trellis model is most effective in demodulating the co-channel signals.

  3. N-slit interference: Path integrals, Bohmian trajectories

    CERN Document Server

    Sbitnev, Valeriy I

    2010-01-01

    Path integrals give a possibility to compute in details routes of particles from particle sources through slit gratings and further to detectors. The path integral for a particle passing through the Gaussian slit results in the Gaussian wavepacket. The wavepackets prepared on N slits and superposed together give rise to interference pattern in the near-field zone. It transforms to diffraction in the far-field zone represented by divergent principal rays, at that all rays are partitioned from each other by (N-2) subsidiary rays. The Bohmian trajectories in the near-field zone of N-slit gratings show wavy behavior. And they become straight in the far-field zone. The trajectories show zigzag behavior on the interference Talbot carpet (ratio of particle wavelength to a distance between slits are much smaller than 1 and N >> 1). Namely, the trajectories prefer to pass through caustics and avoid lacunae, i.e., places with small probability densities. Monochromatic thermal neutrons (wavelength=0.5 nm) simulate radia...

  4. Interference and Interaction in multi-wall carbon nanotubes

    Science.gov (United States)

    Schönenberger, C.; Bachtold, A.; Strunk, C.; Salvetat, J.-P.; Forró, L.

    We report equilibrium electric resistance R and tunneling spectroscopy (dI/dV)measurements obtained on single multi-wall nanotubes contacted by four metallic Au fingers from above. At low temperature quantum interference phenomena dominate the magnetoresistance. The phase-coherence (lφ)and elastic-scattering lengths (le)are deduced. Because le is of order of the circumference of the nanotubes, transport is quasi-ballistic. This result is supported by a dI/dV spectrum which is in good agreement with the density of states (DOS) due to the one-dimensional subbands expected for a perfect single-wall tube. As a function of temperature T the resistance increases on decreasing T and saturates at 1-10 Kfor all measured nanotubes. R(T) cannot be related to the energy-dependent DOS of graphene but is mainly caused by interaction and interference effects. On a relatively small voltage scale of the order 10 meV, a pseudogap is observed in dI/dV which agrees with Luttinger-liquid theories for nanotubes. Because we have used quantum diffusion based on Fermi-liquid as well as Luttinger-liquid theory in trying to understand our results, a large fraction of this paper is devoted to a careful discussion of all our results.

  5. Interference and interaction in multi-wall carbon nanotubes

    Energy Technology Data Exchange (ETDEWEB)

    Schoenenberger, C.; Bachtold, A.; Strunk, C. [Basel Univ. (Switzerland). Inst. fuer Physik; Salvetat, J.P.; Forro, L. [Institut de Genie Atomique, Ecole Polytechnique Federale de Lausanne, CH-1015 Lausanne (Switzerland)

    1999-09-01

    We report equilibrium electric resistance R and tunneling spectroscopy (dI/dV)measurements obtained on single multi-wall nanotubes contacted by four metallic Au fingers from above. At low temperature quantum interference phenomena dominate the magnetoresistance. The phase-coherence (l{sub {phi}})and elastic-scattering lengths (l{sub e})are deduced. Because l{sub e} is of order of the circumference of the nanotubes, transport is quasi-ballistic. This result is supported by a dI/dV spectrum which is in good agreement with the density of states (DOS) due to the one-dimensional subbands expected for a perfect single-wall tube. As a function of temperature T the resistance increases on decreasing T and saturates at {approx}1-10 Kfor all measured nanotubes. R(T) cannot be related to the energy-dependent DOS of graphene but is mainly caused by interaction and interference effects. On a relatively small voltage scale of the order {approx}10 meV, a pseudogap is observed in dI/dV which agrees with Luttinger-liquid theories for nanotubes. Because we have used quantum diffusion based on Fermi-liquid as well as Luttinger-liquid theory in trying to understand our results, a large fraction of this paper is devoted to a careful discussion of all our results. (orig.) With 8 figs., 66 refs.

  6. Communication in a Poisson Field of Interferers -- Part II: Channel Capacity and Interference Spectrum

    CERN Document Server

    Pinto, Pedro C

    2010-01-01

    In Part I of this paper, we presented a mathematical model for communication subject to both network interference and noise, where the interferers are scattered according to a spatial Poisson process, and are operating asynchronously in a wireless environment subject to path loss, shadowing, and multipath fading. We determined the distribution of the aggregate interference and the error performance of the link. In this second part, we characterize the capacity of the link subject to both network interference and noise. Then, we put forth the concept of spectral outage probability (SOP), a new characterization of the aggregate radio-frequency emission generated by communicating nodes in a wireless network. We present some applications of the SOP, namely the establishment of spectral regulations and the design of covert military networks. The proposed framework captures all the essential physical parameters that affect the aggregate network emission, yet is simple enough to provide insights that may be of value...

  7. The differential interference angle in collisional quantum interference on rotational energy transfer

    Institute of Scientific and Technical Information of China (English)

    Wang Wei-Li; Miao Gang; Chen Yue-Hui; Tang Dan; Ma Feng-Cai

    2008-01-01

    Collisional quantum interference (CQI) in the intramolecular rotational energy transfer was observed in experiment by Sha and co-workers.[1] The interference angle, which measuring the degree of the coherence, were measured in the experiment of the static cell. Based on the first Born approximation of time dependent perturbation theory, taking into accounts the anisotropic Lennard-Jones interaction potentials, this paper describes the theoretical model of CQI in intramolecular rotational energy transfer in an atom-diatom collision system. In the model, the differential interference angle for the experiment of the molecular beam is calculated, the changing tendencies of the differential interference angle with the impact parameter and collision partners are obtained. This theoretical model is important for understanding or performing this kind of experiments.

  8. Feedback-Topology Designs for Interference Alignment in MIMO Interference Channels

    CERN Document Server

    Cho, Sungyoon; Huang, Kaibin; Kim, Dongku; Lau, Vincent K N; Seo, Hanbyul; Kim, Byounghoon

    2011-01-01

    Interference alignment (IA) is a joint-transmission technique that achieves the capacity of the interference channel for high signal-to-noise ratios (SNRs). Most prior work on IA is based on the impractical assumption that perfect and global channel-state information(CSI) is available at all transmitters. To implement IA, each receiver has to feed back CSI to all interferers, resulting in overwhelming feedback overhead. In particular, the sum feedback rate of each receiver scales quadratically with the number of users even if the quantized CSI is fed back. To substantially suppress feedback overhead, this paper focuses on designing efficient arrangements of feedback links, called feedback topologies, under the IA constraint. For the multiple-input-multiple-output (MIMO) K-user interference channel, we propose the feedback topology that supports sequential CSI exchange (feedback and feedforward) between transmitters and receivers so as to achieve IA progressively. This feedback topology is shown to reduce the ...

  9. Receive Diversity and Ergodic Performance of Interference Alignment on the MIMO Gaussian Interference Channel

    CERN Document Server

    Guillaud, Maxime

    2010-01-01

    We consider interference alignment (IA) over K-user Gaussian MIMO interference channel (MIMO-IC) when the SNR is not asymptotically high. We introduce a generalization of IA which enables receive diversity inside the interference-free subspace. We generalize the existence criterion of an IA solution proposed by Yetis et al. to this case, thereby establishing a multi-user diversity-multiplexing trade-off (DMT) for the interference channel. Furthermore, we derive a closed-form tight lower-bound for the ergodic mutual information achievable using IA over a Gaussian MIMO-IC with Gaussian i.i.d. channel coefficients at arbitrary SNR, when the transmitted signals are white inside the subspace defined by IA. Finally, as an application of the previous results, we compare the performance achievable by IA at various operating points allowed by the DMT, to a recently introduced distributed method based on game theory.

  10. Elements of Cellular Blind Interference Alignment --- Aligned Frequency Reuse, Wireless Index Coding and Interference Diversity

    CERN Document Server

    Jafar, Syed A

    2012-01-01

    We explore degrees of freedom (DoF) characterizations of partially connected wireless networks, especially cellular networks, with no channel state information at the transmitters. Specifically, we introduce three fundamental elements --- aligned frequency reuse, wireless index coding and interference diversity --- through a series of examples, focusing first on infinite regular arrays, then on finite clusters with arbitrary connectivity and message sets, and finally on heterogeneous settings with asymmetric multiple antenna configurations. Aligned frequency reuse refers to the optimality of orthogonal resource allocations in many cases, but according to unconventional reuse patterns that are guided by interference alignment principles. Wireless index coding highlights both the intimate connection between the index coding problem and cellular blind interference alignment, as well as the added complexity inherent to wireless settings. Interference diversity refers to the observation that in a wireless network ...

  11. Interference of speckle patterns projected by multimode fibers

    Science.gov (United States)

    Lomer, M.; Rodriguez-Cobo, L.; Madruga, F.; Lopez-Higuera, J. M.

    2015-08-01

    In this paper, the interference speckle patterns generated by multimode optical fibers are described. In our experience two types of interference are present, random interference between modes propagated in the fiber that give rise to speckle pattern, and not random speckle interference patterns using a Michelson interferometer generating a pattern of conventional interference. Multimode fibers using different materials and core radii have been obtained interference patterns quality characteristic reducing the effects of modal noise in fiber speckle patterns. Experimental results and their potential applications are presented.

  12. Reliability Estimations of Control Systems Effected by Several Interference Sources

    Institute of Scientific and Technical Information of China (English)

    DengBei-xing; JiangMing-hu; LiXing

    2003-01-01

    In order to establish the sufficient and necessary condition that arbitrarily reliable systems can not be constructed with function elements under interference sources, it is very important to expand set of interference sources with the above property. In this paper, the models of two types of interference sources are raised respectively: interference source possessing real input vectors and constant reliable interferen cesource. We study the reliability of the systems effected by the interference sources, and the lower bound of the reliability is presented. The results show that it is impossible that arbitrarily reliable systems can not be constructed with the elements effected by above interference sources.

  13. Dependency-dependent interference: NPI interference, agreement attraction, and global pragmatic inferences.

    Science.gov (United States)

    Xiang, Ming; Grove, Julian; Giannakidou, Anastasia

    2013-01-01

    Previous psycholinguistics studies have shown that when forming a long distance dependency in online processing, the parser sometimes accepts a sentence even though the required grammatical constraints are only partially met. A mechanistic account of how such errors arise sheds light on both the underlying linguistic representations involved and the processing mechanisms that put such representations together. In the current study, we contrast the negative polarity items (NPI) interference effect, as shown by the acceptance of an ungrammatical sentence like "The bills that democratic senators have voted for will ever become law," with the well-known phenomenon of agreement attraction ("The key to the cabinets are … "). On the surface, these two types of errors look alike and thereby can be explained as being driven by the same source: similarity based memory interference. However, we argue that the linguistic representations involved in NPI licensing are substantially different from those of subject-verb agreement, and therefore the interference effects in each domain potentially arise from distinct sources. In particular, we show that NPI interference at least partially arises from pragmatic inferences. In a self-paced reading study with an acceptability judgment task, we showed NPI interference was modulated by participants' general pragmatic communicative skills, as quantified by the Autism-Spectrum Quotient (AQ, Baron-Cohen et al., 2001), especially in offline tasks. Participants with more autistic traits were actually less prone to the NPI interference effect than those with fewer autistic traits. This result contrasted with agreement attraction conditions, which were not influenced by individual pragmatic skill differences. We also show that different NPI licensors seem to have distinct interference profiles. We discuss two kinds of interference effects for NPI licensing: memory-retrieval based and pragmatically triggered.

  14. Dependency-dependent interference: NPI interference, agreement attraction, and global pragmatic inferences

    Directory of Open Access Journals (Sweden)

    Ming eXiang

    2013-10-01

    Full Text Available Previous psycholinguistics studies have shown that when forming a long distance dependency in online processing, the parser sometimes accepts a sentence even though the required grammatical constraints are only partially met. A mechanistic account of how such errors arise sheds light on both the underlying linguistic representations involved and the processing mechanisms that put such representations together. In the current study, we contrast the NPI (negative polarity items interference effect, as shown by the acceptance of an ungrammatical sentence like The bills that democratic senators have voted for will ever become law, with the well-known phenomenon of agreement attraction (The key to the cabinets are…. On the surface, these two types of errors look alike and thereby can be explained as being driven by the same source: similarity based memory interference. However, we argue that the linguistic representations involved in NPI licensing are substantially different from those of subject-verb agreement, and therefore the interference effects in each domain potentially arise from distinct sources. In particular, we show that NPI interference at least partially arises from pragmatic inferences. In a self-paced reading study with an acceptability judgment task, we showed NPI interference was modulated by participants’ general pragmatic communicative skills, as quantified by the Autism-Spectrum Quotient (Baron-Cohen 2001, especially in offline tasks. Participants with more autistic traits were actually less prone to the NPI interference effect than those with fewer autistic traits. This result contrasted with agreement attraction conditions, which were not influenced by individual pragmatic skill differences. We also show that different NPI licensors have distinct interference profiles. We discuss two kinds of interference effects for NPI licensing: memory-retrieval based and pragmatically triggered.

  15. Effects of E2 and E1-E2 Interference on Coulomb Dissociation of 19C

    Institute of Scientific and Technical Information of China (English)

    Rajesh Kharab; Pardeep Singh; Ravinder Kumar

    2007-01-01

    We investigate the effects of higher order multipole transitions, in particular electric quadrupole (E2) and E1-E2interference, on the Coulomb dissociation of 19 C within the framework of the first order eikonal approximation.The sensitivity of the total Coulomb breakup cross section and the longitudinal momentum distribution of the core fragment to these effects are checked. The breakup occurs predominately through the dipole transition and the contribution of E2 transition to the total cross section is found to be within the range from 1 to 3% of that of E1. It is further observed that the E1-E2 interference term contributes nothing to the integrated cross section.On the other hand, the longitudinal momentum distribution is observed to be insensitive to the E2 transition while the E1-E2 interference introduces a small asymmetry in its shape.

  16. Micron size superconducting quantum interference devices of lead (Pb)

    Science.gov (United States)

    Paul, Sagar; Biswas, Sourav; Gupta, Anjan K.

    2017-02-01

    Micron size superconducting quantum interference devices (μ-SQUID) of lead (Pb), for probing nano-magnetism, were fabricated and characterized. In order to get continuous Pb films with small grain size, Pb was thermally evaporated on a liquid nitrogen cooled Si substrate. Pb was sandwiched between two thin Cr layers for improved adhesion and protection. The SQUID pattern was made by e-beam lithography with Pb lift-off after deposition. The current-voltage characteristics of these devices show a critical current, which exhibits the expected SQUID oscillations with magnetic field, and two re-trapping currents. As a result these devices have hysteresis at low temperatures, which disappears just below the critical temperature.

  17. Statistical Learning in Automated Troubleshooting: Application to LTE Interference Mitigation

    CERN Document Server

    Tiwana, Moazzam Islam; Altman, Zwi

    2010-01-01

    This paper presents a method for automated healing as part of off-line automated troubleshooting. The method combines statistical learning with constraint optimization. The automated healing aims at locally optimizing radio resource management (RRM) or system parameters of cells with poor performance in an iterative manner. The statistical learning processes the data using Logistic Regression (LR) to extract closed form (functional) relations between Key Performance Indicators (KPIs) and Radio Resource Management (RRM) parameters. These functional relations are then processed by an optimization engine which proposes new parameter values. The advantage of the proposed formulation is the small number of iterations required by the automated healing method to converge, making it suitable for off-line implementation. The proposed method is applied to heal an Inter-Cell Interference Coordination (ICIC) process in a 3G Long Term Evolution (LTE) network which is based on soft-frequency reuse scheme. Numerical simulat...

  18. 核糖核酸干扰%The RNA interference

    Institute of Scientific and Technical Information of China (English)

    孔祥平; LiXing W.Reneker

    2004-01-01

    The phenomenon of RNA interference (RNAi) is highly conserved mechanism in the organism evolution. As a immune system ,RNAi is a ubiquitous mechanism against invading microorganism in plant and animal cells. Recently, it has been found that RNAi is the process by which double-strand RNA(dsRNA) directs sequence-specific degradation of messenger RNA and the mediations of sequence specific messenger RNA degradation are 21-and 23-nucleotide small interfering RNAs that generate by ribonuclease from endogenous longer dsRNA or by transfectious technics from heterologous dsRNA. Over the past few years, the way in which cells respond to dsRNA by silencing homologous genes has revealed a new regulating paradigm in biology.

  19. Generation of siRNA Nanosheets for Efficient RNA Interference

    Science.gov (United States)

    Kim, Hyejin; Lee, Jae Sung; Lee, Jong Bum

    2016-04-01

    After the discovery of small interference RNA (siRNA), nanostructured siRNA delivery systems have been introduced to achieve an efficient regulation of the target gene expression. Here we report a new siRNA-generating two dimensional nanostructure in a formation of nanosized sheet. Inspired by tunable mechanical and functional properties of the previously reported RNA membrane, siRNA nanosized sheets (siRNA-NS) with multiple Dicer cleavage sites were prepared. The siRNA-NS has two dimensional structure, providing a large surface area for Dicer to cleave the siRNA-NS for the generation of functional siRNAs. Furthermore, downregulation of the cellular target gene expression was achieved by delivery of siRNA-NS without chemical modification of RNA strands or conjugation to other substances.

  20. Exotic Looped Trajectories of Photons in Three-Slit Interference

    CERN Document Server

    Magana-Loaiza, Omar S; Mirhosseini, Mohammad; Fickler, Robert; Safari, Akbar; Mick, Uwe; McIntyre, Brian; Banzer, Peter; Rodenburg, Brandon; Leuchs, Gerd; Boyd, Robert W

    2016-01-01

    The validity of the superposition principle and of Born's rule are well-accepted tenants of quantum mechanics. Surprisingly, it has recently been predicted that the intensity pattern formed in a three-slit experiment is seemingly in contradiction with the predictions of the most conventional form of the superposition principle when exotic looped trajectories are taken into account. However, the probability of observing such paths is typically very small and thus rendering them extremely difficult to measure. In this work, we confirm the validity of Born's rule and present the first experimental observation of these exotic trajectories as additional paths for the light by directly measuring their contribution to the formation of optical interference fringes. We accomplish this by enhancing the electromagnetic near-fields in the vicinity of the slits through the excitation of surface plasmons. This process effectively increases the probability of occurrence of these exotic trajectories, demonstrating that they ...

  1. Neuron-specific RNA interference using lentiviral vectors

    DEFF Research Database (Denmark)

    Nielsen, Troels Tolstrup; Marion, Ingrid van; Hasholt, Lis

    2009-01-01

    BACKGROUND: Viral vectors have been used in several different settings for the delivery of small hairpin (sh) RNAs. However, most vectors have utilized ubiquitously-expressing polymerase (pol) III promoters to drive expression of the hairpin as a result of the strict requirement for precise...... transcriptional initiation and termination. Recently, pol II promoters have been used to construct vectors for RNA interference (RNAi). By embedding the shRNA into a micro RNA-context (miRNA) the endogenous miRNA processing machinery is exploited to achieve the mature synthetic miRNA (smiRNA), thereby expanding...... the possible promoter choices and eventually allowing cell type specific down-regulation of target genes. METHODS: In the present study, we constructed lentiviral vectors expressing smiRNAs under the control of pol II promoters to knockdown gene expression in cell culture and in the brain. RESULTS: We...

  2. Interference tables: a useful model for interference analysis in asynchronous multicarrier transmission

    Science.gov (United States)

    Medjahdi, Yahia; Terré, Michel; Ruyet, Didier Le; Roviras, Daniel

    2014-12-01

    In this paper, we investigate the impact of timing asynchronism on the performance of multicarrier techniques in a spectrum coexistence context. Two multicarrier schemes are considered: cyclic prefix-based orthogonal frequency division multiplexing (CP-OFDM) with a rectangular pulse shape and filter bank-based multicarrier (FBMC) with physical layer for dynamic spectrum access and cognitive radio (PHYDYAS) and isotropic orthogonal transform algorithm (IOTA) waveforms. First, we present the general concept of the so-called power spectral density (PSD)-based interference tables which are commonly used for multicarrier interference characterization in spectrum sharing context. After highlighting the limits of this approach, we propose a new family of interference tables called `instantaneous interference tables'. The proposed tables give the interference power caused by a given interfering subcarrier on a victim one, not only as a function of the spectral distance separating both subcarriers but also with respect to the timing misalignment between the subcarrier holders. In contrast to the PSD-based interference tables, the accuracy of the proposed tables has been validated through different simulation results. Furthermore, due to the better frequency localization of both PHYDYAS and IOTA waveforms, FBMC technique is demonstrated to be more robust to timing asynchronism compared to OFDM one. Such a result makes FBMC a potential candidate for the physical layer of future cognitive radio systems.

  3. (Sub-)Optimality of Treating Interference as Noise in the Cellular Uplink With Weak Interference

    KAUST Repository

    Gherekhloo, Soheil

    2015-11-09

    Despite the simplicity of the scheme of treating interference as noise (TIN), it was shown to be sum-capacity optimal in the Gaussian interference channel (IC) with very-weak (noisy) interference. In this paper, the two-user IC is altered by introducing an additional transmitter that wants to communicate with one of the receivers of the IC. The resulting network thus consists of a point-to-point channel interfering with a multiple access channel (MAC) and is denoted by PIMAC. The sum-capacity of the PIMAC is studied with main focus on the optimality of TIN. It turns out that TIN in its naive variant, where all transmitters are active and both receivers use TIN for decoding, is not the best choice for the PIMAC. In fact, a scheme that combines both time division multiple access and TIN (TDMA-TIN) strictly outperforms the naive-TIN scheme. Furthermore, it is shown that in some regimes, TDMA-TIN achieves the sum-capacity for the deterministic PIMAC and the sum-capacity within a constant gap for the Gaussian PIMAC. In addition, it is shown that, even for very-weak interference, there are some regimes where a combination of interference alignment with power control and TIN at the receiver side outperforms TDMA-TIN. As a consequence, on the one hand, TIN in a cellular uplink is approximately optimal in certain regimes. On the other hand, those regimes cannot be simply described by the strength of interference.

  4. The Approximate Capacity Region of the Symmetric $K$-user Gaussian Interference Channel with Strong Interference

    KAUST Repository

    Chaaban, Anas

    2016-03-01

    The symmetric K-user interference channel is studied with the goal of characterizing its capacity region in the strong interference regime within a constant gap. The achievable rate region of a scheme combining rate-splitting at the transmitters and interference alignment and successive decoding/computation at the receivers is derived. Next it is shown that this scheme achieves the so-called greedy-max corner points of the capacity region within a constant gap. By combining this result with previous results by Ordentlich et al. on the sum-capacity of the symmetric interference channel, a constant gap characterization of the capacity region for the strong interference regime is obtained. This leads to the first approximate characterization of the capacity region of the symmetric K-user IC. Furthermore, a new scheme that achieves the sum-capacity of the channel in the strong interference regime within a constant gap is also proposed, and the corresponding gap is calculated. The advantage of the new scheme is that it leads to a characterization within a constant gap without leaving an outage set contrary to the scheme by Ordentlich et al..

  5. A chirp modem incorporating interference excision

    Science.gov (United States)

    Darbyshire, E. P.; Gott, G. F.

    1992-08-01

    The paper describes an experimental 75-baud chirp modem designed to operate at high frequency (HF), which is able to reject interference from other HF users by adaptive filtering at the receiver. It also has inherently good performance in multipath preparation and in white noise, and is thus capable of robust digital communication. The system has been tested over a 170 km point-to-point HF skywave link, in which short chirp messages (approximately 30 s duration) were alternated in time with frequency-exchange keyed (FEK) messages. The total duration of the tests was 72 hours, and included day and night operation. In these tests, the chirp system had an overall performance which was superior to that of FEK. FEK occasionally suffered from long periods (e.g., 1 hour) of severe failure, essentially due to interference, whereas the chirp modem achieved more continuous useful operation.

  6. Interference and Chaos in Metamaterials Cavities

    Science.gov (United States)

    Litchinitser, Natalia; Jose, Jorge

    2014-03-01

    Optical metamaterials are engineered artificial nanostructures that possess optical properties not available in nature. As metamaterials research continues to mature, their practical applications as well as fundamental questions on wave propagation in these materials attract significant interest. In this talk we focus on wave propagation and interference in chaotic wave cavities with negative or near-zero index of refraction and in double-slit configurations. In this context, we explicitly consider an incomplete two-dimensional D-cavity previously studied, which shows chaotic ray propagation together with scars. We have addressed the question as to how that type of wave propagation is modified by adding metamaterials in these chaotic cavities. We find that the wave interference patterns show significant qualitatively and quantitative changes depending on the effective parameters of the cavity, illumination conditions (planes waves versus beams), and geometry of the system. We will discuss possible experimental setups where these results may be validated.

  7. Heuristic explanation of quantum interference experiments

    CERN Document Server

    Guowen, W

    2005-01-01

    A particle is described as a non-spreading wave packet satisfying a linear equation within the framework of special relativity. Young's and other interference experiments are explained with a hypothesis that there is a coupling interaction between the peaked and non-peaked pieces of the wave packet. This explanation of the interference experiments provides a realistic interpretation of quantum mechanics. The interpretation implies that there is physical reality of particles and no wave function collapse. It also implies that neither classical mechanics nor current quantum mechanics is a complete theory for describing physical reality and the Bell inequalities are not the proper touchstones for reality and locality. The problems of the boundary between the macro-world and micro-world and the de-coherence in the transition region (meso-world) between the two are discussed. The present interpretation of quantum mechanics is consistent with the physical aspects of the Copenhagen interpretation, such as, the super...

  8. Unruh effect and macroscopic quantum interference

    CERN Document Server

    Steane, Andrew

    2015-01-01

    We investigate the influence of Unruh radiation on matter-wave interferometry experiments using neutral objects modeled as dielectric spheres. The Unruh effect leads to a loss of coherence through momentum diffusion. This is a fundamental source of decoherence that affects all objects having electromagnetic interactions. However, the effect is not large enough to prevent the observation of interference for objects of any size, even when the path separation is larger than the size of the object. When the acceleration in the interferometer arms is large, inertial tidal forces will disrupt the material integrity of the interfering objects before the Unruh decoherence of the centre of mass motion is sufficient to prevent observable interference.

  9. Revealing interference by continuous variable discordant states.

    Science.gov (United States)

    Meda, A; Olivares, S; Degiovanni, I P; Brida, G; Genovese, M; Paris, M G A

    2013-08-15

    In general, a pair of uncorrelated Gaussian states mixed in a beam splitter (BS) produces a correlated state at the output. However, when the inputs are identical Gaussian states the output state is equal to the input, and no correlations appear, as the interference had not taken place. On the other hand, since physical phenomena do have observable effects, and the BS is there, a question arises on how to reveal the interference between the two beams. We prove theoretically and demonstrate experimentally that this is possible if at least one of the two beams is prepared in a discordant, i.e., Gaussian correlated, state with a third beam. We also apply the same technique to reveal the erasure of polarization information. Our experiment involves thermal states and the results show that Gaussian discordant states, even when they show a positive Glauber P-function, may be useful to achieve specific tasks.

  10. Interference Rejection Techniques in DSSS Communication System

    Institute of Scientific and Technical Information of China (English)

    GONGXiangyang; HUGuangrui

    2003-01-01

    It is known that the narrowband interfer-ence rejection capability of a direct sequence (DS) spread spectrum (SS) system can be enhanced considerably by an interference rejection algorithm prior to correlating it with the pseudo noise (PN) sequence. For narrowband gaussian noise (NGN), the techniques in common use are transver-sal filter. It models SS signal and NGN as stationary, then utilizes temporal correlation difference between SS signal and NBL however, SS signal and NGN are cyclostation-ary (CS). CS signal has correlation in frequency domain called spectrum correlation, which can not be employed by transversal filter. In this article, SS signal and NBIare modeled as CS and FRESH filter is adopted to exploit the correlation both in time domain and frequency domain.Computer simulation shows that FRESH filter can improve the system performance considerably compared with con-ventional transversal filter.

  11. Many-body quantum interference on hypercubes

    Science.gov (United States)

    Dittel, Christoph; Keil, Robert; Weihs, Gregor

    2017-03-01

    Beyond the regime of distinguishable particles, many-body quantum interferences influence quantum transport in an intricate manner. However, symmetries of the single-particle transformation matrix alleviate this complexity and even allow the analytic formulation of suppression laws, which predict final states to occur with a vanishing probability due to total destructive interference. Here we investigate the symmetries of hypercube graphs and their generalisations with arbitrary identical subgraphs on all vertices. We find that initial many-particle states, which are invariant under self-inverse symmetries of the hypercube, lead to a large number of suppressed final states. The condition for suppression is determined solely by the initial symmetry, while the fraction of suppressed states is given by the number of independent symmetries of the initial state. Our findings reveal new insights into particle statistics for ensembles of indistinguishable bosons and fermions and may represent a first step towards many-particle quantum protocols in higher-dimensional structures.

  12. Intercell Interference Coordination through Limited Feedback

    Directory of Open Access Journals (Sweden)

    Lingjia Liu

    2010-01-01

    Full Text Available We consider the applications of multicell transmission schemes to the downlink of future wireless communication networks. A multicell multiple-input multiple output-(MIMOs based scheme with limited coordination among neighboring base stations (BSs is proposed to effectively combat the intercell interference by taking advantage of the degreesoffreedom in the spatial domain. In this scheme, mobile users are required to feedback channel-related information to both serving base station and interfering base station. Furthermore, a chordal distance-based compression scheme is introduced to reduce the feedback overhead. The performance of the proposed scheme is investigated through theoretical analysis as well as system level simulations. Both results suggest that the so-called “intercell interference coordination through limited feedback” scheme is a very good candidate for improving the cell-edge user throughput as well as the average cell throughput of the future wireless communication networks.

  13. Topological Mass Generation as an Interference Phenomenon

    CERN Document Server

    Ilha, A; Ilha, Anderson; Wotzasek, Clovis

    2000-01-01

    It is proposed a new mechanism for the phenomenon of topological mass generation in three spacetime dimensions as the result of the interference of two opposite massless chiral modes. This mechanism, already used to produce the massive vectorial mode of the 2D Schwinger model, is here exploited to produce the gauge invariant massive mode of the Maxwell-Chern-Simons theory. Moreover the procedure is clearly dimensionally independent: a new chiral boson action is proposed for odd and even dimensional space-times to be used as the basic building blocks of the interference schemes. This is a new result that extends the two-dimensional Floreanini-Jackiw action to higher dimensional spaces and is in clear contrast with the twice odd dimensional chiral form extensions.

  14. Interference Phenomenon for Different Chiral Bosonization Schemes

    CERN Document Server

    Abreu, Everton M C; Abreu, Everton M C; Wotzasek, Clovis

    1998-01-01

    We study the relationship between different chiral bosonization schemes (CBS) in the context of the soldering formalism\\cite{MS}, that considers the phenomenon of interference in the quantum field theory\\cite{ABW}. This analysis is done in the framework put forward by Siegel\\cite{WS} and by Floreanini and Jackiw\\cite{FJ} (FJ). We propose a field redefinition that discloses the presence of a noton, a non dynamical field, in Siegel's formulation for chiral bosons. The presence of a noton in the Siegel CBS is a new and surprising result, that separates dynamics from symmetry by diagonalising the Siegel action into the FJ and the noton action. While the first describes the chiral dynamics, the noton carries the symmetry contents, acquiring dynamics upon quantization and is fully responsible for the Siegel anomaly. The diagonal representation proposed here is used to study the effect of quantum interference between gauged rightons and leftons.

  15. Phasor Measurement Unit under Interference Conditions

    DEFF Research Database (Denmark)

    Ghiga, Radu; Martin, Kenneth E.; Wu, Qiuwei

    2017-01-01

    This paper investigates the performance of Phasor Measurement Units (PMUs) under interference conditions which can appear in a power system and are not tested by the C37.118.1 standard. Three PMUs from different vendors configured for the M-class requirements were used to test three possible inte...... robust PMUs and applications resistant to degraded measurements.......This paper investigates the performance of Phasor Measurement Units (PMUs) under interference conditions which can appear in a power system and are not tested by the C37.118.1 standard. Three PMUs from different vendors configured for the M-class requirements were used to test three possible...... scenario focuses on instrument transformer saturation which leads to a modified waveform injected in the PMU. This test goes through different levels of Current Transformer (CT) saturation and analyzes the effect of saturation on the accuracy of PMUs. The test results show PMU measurements will be degraded...

  16. Index Coding - An Interference Alignment Perspective

    CERN Document Server

    Maleki, Hamed; Jafar, Syed A

    2012-01-01

    The index coding problem is studied from an interference alignment perspective, providing new results as well as new insights into, and generalizations of, previously known results. An equivalence is established between multiple unicast index coding where each message is desired by exactly one receiver, and multiple groupcast index coding where a message can be desired by multiple receivers, which settles the heretofore open question of insufficiency of linear codes for the multiple unicast index coding problem by equivalence with multiple groupcast settings where this question has previously been answered. Necessary and sufficient conditions for the achievability of rate half per message are shown to be a natural consequence of interference alignment constraints, and generalizations to feasibility of rate $\\frac{1}{L+1}$ per message when each destination desires at least $L$ messages, are similarly obtained. Finally, capacity optimal solutions are presented to a series of symmetric index coding problems insp...

  17. Belief Propagation Methods for Intercell Interference Coordination

    CERN Document Server

    Rangan, Sundeep

    2010-01-01

    We consider a broad class of interference coordination and resource allocation problems for wireless links where the goal is to maximize the sum of functions of individual link rates. Such problems arise in the context of, for example, fractional frequency reuse (FFR) for macro-cellular networks and dynamic interference management in femtocells. The resulting optimization problems are typically hard to solve optimally even using centralized algorithms but are an essential computational step in implementing rate-fair and queue stabilizing scheduling policies in wireless networks. We consider a belief propagation framework to solve such problems approximately. In particular, we construct approximations to the belief propagation iterations to obtain computationally simple and distributed algorithms with low communication overhead. Notably, our methods are very general and apply to, for example, the optimization of transmit powers, transmit beamforming vectors, and sub-band allocation to maximize the above object...

  18. Interference Alignment with Analog Channel State Feedback

    CERN Document Server

    Ayach, Omar El

    2010-01-01

    Interference alignment (IA) is a multiplexing gain optimal transmission strategy for the interference channel with an arbitrary number of users. While the achieved sum rate with IA is much higher than previously thought possible, the improvement comes at the cost of requiring network channel state information at the transmitters. This can be achieved by explicit feedback, a flexible yet costly approach that incurs large overhead and limits throughput. We propose using analog feedback as an alternative to limited feedback or reciprocity based alignment. We show that the full multiplexing gain observed with perfect channel knowledge is preserved by analog feedback and the mean loss in sum rate is bounded by a constant when signal-to-noise ratio is comparable in both forward and feedback channels. When such feedback quality is not quite possible, a fraction of the degrees of freedom is achieved. We consider the overhead of training and feedback and use this framework to optimize the system's effective throughput...

  19. Diffraction and interference of walking drops

    Science.gov (United States)

    Pucci, Giuseppe; Harris, Daniel M.; Bush, John W. M.

    2016-11-01

    A decade ago, Yves Couder and Emmanuel Fort discovered a wave-particle association on the macroscopic scale: a drop can bounce indefinitely on a vibrating bath of the same liquid and can be piloted by the waves that it generates. These walking droplets have been shown to exhibit several quantum-like features, including single-particle diffraction and interference. Recently, the original diffraction and interference experiments of Couder and Fort have been revisited and contested. We have revisited this system using an improved experimental set-up, and observed a strong dependence of the behavior on system parameters, including drop size and vibrational forcing. In both the single- and the double-slit geometries, the diffraction pattern is dominated by the interaction of the walking droplet with a planar boundary. Critically, in the double-slit geometry, the walking droplet is influenced by both slits by virtue of its spatially extended wave field. NSF support via CMMI-1333242.

  20. rf superconducting quantum interference device metamaterials

    Science.gov (United States)

    Lazarides, N.; Tsironis, G. P.

    2007-04-01

    A rf superconducting quantum interference device (SQUID) array in an alternating magnetic field is investigated with respect to its effective magnetic permeability, within the effective medium approximation. This system acts as an inherently nonlinear magnetic metamaterial, leading to negative magnetic response, and thus negative permeability above the resonance frequency of the individual SQUIDs. Moreover, the permeability exhibits oscillatory behavior at low field intensities, allowing its tuning by a slight change of the intensity of the applied field.

  1. Research Progress on Multimode Interference Switches

    Institute of Scientific and Technical Information of China (English)

    GAO Qing; SHENG Zhi-rui; JIANG Xiao-qing; WANG Ming-hua

    2005-01-01

    Optical switches are key components for constructing optical communication networks, so it is necessary to design optical switches and optical switch arrays with high performance and low cost. As one type of optical switches, the multimode interference(MMI) switches have received considerable attention due to their unique merits. The structures and operation principles of various types of MMI switches are introduced,and the recent progresses of MMI switches are also discussed.

  2. Interference comb-spectroscopy with increasing sensitivity

    Science.gov (United States)

    Pulkin, Sergey; Borisov, Evgenii; Balabas, Michail; Uvarova, Svetlana; Shevtzov, Vladimir; Kalinichev, Alexei; Shoev, Vladislav; Venediktov, Dmitrii; Venediktov, Vladimir

    2016-10-01

    The paper considers the use of holographic interferometer for hologram recording of the wide spectrum from the comb - generator of the femtosecond laser was applied for illuminating of Michelson interferometer with atomic vapor. The behavior of spectral interference fringes on the exit slit of spectrograph reflects the behavior of nonlinear refractive index. The method of holographic interferometry with increasing sensitivity using phase modulator was applied for digital hologram processing.

  3. Development of Studies on RNA Interference

    Institute of Scientific and Technical Information of China (English)

    Li ZHANG; Yaqiong ZHANG; Lina SHE; Wenting XU; Yangying JIA; Shiqing XIE; WenliSUN; Quan LIANG

    2012-01-01

    RNA interference (RNAi), caused by endogenous or exogenous double- stranded RNA (dsRNA) homologous with target genes, refers to gene silencing widely existing in animals and plants. It was first found in plants, and now it has developed into a kind of biotechnology as well as an important approach in post- genome era. This paper is to summarize the achievements of studies on RNAi tech- nology in basic biology, medicine, pharmacy, botany and other fields.

  4. In Vivo Imaging of RNA Interference

    OpenAIRE

    Hong, Hao; Zhang,Yin; Cai, Weibo

    2010-01-01

    RNA interference (RNAi), an effective technique for regulating/silencing specific genes, can be applied to treat various diseases. Multiple clinical trials using RNAi are ongoing and molecular imaging can serve as a powerful tool in RNAi-based therapies. This brief review will highlight the current progress on in vivo imaging of RNAi delivery and silencing effects. Incorporation of suitable molecular imaging techniques into future RNAi-based clinical trials will provide more pieces of the puz...

  5. Control and signal processing by transcriptional interference

    OpenAIRE

    2009-01-01

    A transcriptional activator can suppress gene expression by interfering with transcription initiated by another activator. Transcriptional interference has been increasingly recognized as a regulatory mechanism of gene expression. The signals received by the two antagonistically acting activators are combined by the polymerase trafficking along the DNA. We have designed a dual-control genetic system in yeast to explore this antagonism systematically. Antagonism by an upstream activator bears ...

  6. Interference Cancellation in Cooperative CDMA Networks

    Directory of Open Access Journals (Sweden)

    A. Rajeswari

    2011-01-01

    Full Text Available The wireless communication networks are subjected to multi access interference and multipath fading. To minimize the interference cancellation in CDMA networks, multiple user detection schemes and cooperative communication networks are used. consider the uplink of a cooperative CDMA network, where users cooperate by relaying each other’s messages to the base station. When spreading waveforms are not orthogonal, multiple access interference (MAI exists at the relays and the destination, causing cooperative diversity gains to diminish. To overcome this problem, we integrate various multiuser detection (MUD schemes to mitigate MAI in achieving the full advantages of cooperation. Specifically, the relay-assisted decorrelating multiuser detector (RADMUD is proposed to separate interfering signals at the destination with the help of precoding at the relays along with pre-whitening at the destination. In this paper we examined the BER performance of various MUD schemes are analyzed and compared with cooperative system. The advantages of RAD-MUD with co-operative communication shows better BER performance compared with non co-operative wireless communication system and other existing cooperative MUD schemes are also shown through MATLAB Simulations.

  7. Eliminating ultrasonic interference from respiratory muscle EMG.

    Science.gov (United States)

    Platt, R S; Kieser, T M; Easton, P A

    1998-05-01

    Fine wire recordings of the respiratory muscle electromyogram are often employed to represent muscle activity, and recently ultrasound-sonomicrometry has become a common method of measuring length of respiratory muscles in both acute and chronic preparations. Although recording both EMG and sonomicrometry simultaneously has become standard practice, there has not been any consideration of the potential confounding influence of ultrasound noise upon the recorded EMG spectrum. Activation of the sonomicrometry-ultrasound tranducer introduces a high frequency, high amplitude voltage pulse plus harmonics, which can contaminate the EMG spectrum directly, as well as through aliasing when EMG is sampled directly digitally. We describe the use of a new, combined, wing stabilized sonomicrometry- and EMG measurement transducer to characterize exactly the influence of ultrasound upon the crural diaphragm EMG spectrum, and the development of digital filtering techniques which effectively eliminate the ultrasound interference. Two alternative methods of avoiding ultrasound-EMG interference are also considered. The isolation and elimination of ultrasound-sonomicrometry signal interference may be important in studies where EMG and length are measured together.

  8. Visual working memory capacity and proactive interference.

    Directory of Open Access Journals (Sweden)

    Joshua K Hartshorne

    Full Text Available BACKGROUND: Visual working memory capacity is extremely limited and appears to be relatively immune to practice effects or the use of explicit strategies. The recent discovery that visual working memory tasks, like verbal working memory tasks, are subject to proactive interference, coupled with the fact that typical visual working memory tasks are particularly conducive to proactive interference, suggests that visual working memory capacity may be systematically under-estimated. METHODOLOGY/PRINCIPAL FINDINGS: Working memory capacity was probed behaviorally in adult humans both in laboratory settings and via the Internet. Several experiments show that although the effect of proactive interference on visual working memory is significant and can last over several trials, it only changes the capacity estimate by about 15%. CONCLUSIONS/SIGNIFICANCE: This study further confirms the sharp limitations on visual working memory capacity, both in absolute terms and relative to verbal working memory. It is suggested that future research take these limitations into account in understanding differences across a variety of tasks between human adults, prelinguistic infants and nonlinguistic animals.

  9. Interference Phenomena in Medium Induced Radiation

    CERN Document Server

    Casalderrey-Solana, Jorge

    2011-01-01

    We consider the interference pattern for the medium-induced gluon radiation produced by a color singlet quark-antiquark antenna embedded in a QCD medium with size $L$ and `jet quenching' parameter $\\hat q$. Within the BDMPS-Z regime, we demonstrate that, for a dipole opening angle $\\theta_{q\\bar q} \\gg\\theta_c\\equiv {2}/{\\sqrt{\\hat q L^3}}$, the interference between the medium--induced gluon emissions by the quark and the antiquark is suppressed with respect to the direct emissions. This is so since direct emissions are delocalized throughout the medium and thus yield contributions proportional to $L$ while interference occurs only between emissions at early times, when both sources remain coherent. Thus, for $\\tqq \\gg\\theta_c$, the medium-induced radiation is the sum of the two spectra individually produced by the quark and the antiquark, without coherence effects like angular ordering. For $\\tqq \\ll\\theta_c$, the medium--induced radiation vanishes.

  10. Immunizing digital systems against electromagnetic interference

    Science.gov (United States)

    Ewing, P. D.; Korsah, K.; Antonescu, C.

    This paper discusses the development of the technical basis for acceptance criteria applicable to the immunization of digital systems against electromagnetic interference (EMI). The work is sponsored by the US Nuclear Regulatory Commission and stems from the safety-related issues that need to be addressed as a result of the application of digital instrumentation and control systems in nuclear power plants. Designers of digital circuits are incorporating increasingly higher clock frequencies and lower logic level voltages, thereby leading to potentially greater susceptibility of spurious interference being misinterpreted as legitimate logic. Development of the technical basis for acceptance criteria to apply to these digital systems centers around establishing good engineering practices to ensure that sufficient levels of electromagnetic compatibility (EMC) are maintained between the nuclear power plant's electronic and electromechanical systems. First, good EMC design and installation practices are needed to control the emissions from interference sources and thereby their impact on other nearby circuits and systems. Secondly, a test and evaluation program is needed to outline the EMI tests to be performed, the associated test methods to be followed, and adequate test limits to ensure that the circuit or system under test meets the recommended guidelines. Test and evaluation should be followed by periodic maintenance to assess whether the recommended EMI control practices continue to be adhered to as part of the routine operation of the nuclear power plant. By following these steps, the probability of encountering safety-related instrumentation problems associated with EMI will be greatly reduced.

  11. Interference of allelopathic wheat with different weeds.

    Science.gov (United States)

    Zhang, Song-Zhu; Li, Yong-Hua; Kong, Chui-Hua; Xu, Xiao-Hua

    2016-01-01

    Interference of allelopathic wheat with weeds involves a broad spectrum of species either independently or synergistically with competitive factors. This study examined the interference of allelopathic wheat with 38 weeds in relation to the production of allelochemical 2,4-dihydroxy-7-methoxy-1,4-benzoxazin-3-one (DIMBOA) in wheat with and without root-root interactions. There were substantial differences in weed biomass and DIMBOA concentration in wheat-weed coexisting systems. Among 38 weeds, nine weeds were inhibited significantly by allelopathic wheat but the other 29 weeds were not. DIMBOA levels in wheat varied greatly with weed species. There was no significant relationship between DIMBOA levels and weed suppression effects. Root segregation led to great changes in weed inhibition and DIMBOA level. Compared with root contact, the inhibition of eight weeds was lowered significantly, while significantly increased inhibition occurred in 11 weeds with an increased DIMBOA concentration under root segregation. Furthermore, the production of DIMBOA in wheat was induced by the root exudates from weeds. Interference of allelopathic wheat with weeds not only is determined by the specificity of the weeds but also depends on root-root interactions. In particular, allelopathic wheat may detect certain weeds through the root exudates and respond by increasing the allelochemical, resulting in weed identity recognition. © 2015 Society of Chemical Industry.

  12. Interference suppression in noise radar systems

    Science.gov (United States)

    Djukanović, Slobodan; Daković, Miloš; Thayaparan, Thayananthan; Stanković, Ljubiša

    2011-06-01

    This paper addresses the issue of interference suppression in noise radars. The proposed methods can be divided into non-parametric and parametric ones. The considered non-parametric methods are based on linear time-frequency (TF) tools, namely the short-time Fourier transform (STFT) and local polynomial Fourier transform (LPFT). The STFT is the simplest TF method, but, due to the resolution problem, it performs poorly with highly nonstationary interferences. The LPFT resolves the resolution problem, however at the cost of increased complexity. In parametric methods, the phase of interference is locally approximated by a polynomial, which is motivated by the Weierstrass's theorem. Using the phase approximation, the corrupted received signal is demodulated and successively filtered. Two methods for polynomial phase approximation are considered, the high-order ambiguity function (HAF) and product high-order ambiguity function (PHAF). The method based on the HAF is computationally efficient; however, it suffers from the identifiability problem when multicomponent signals are considered. The identifiability problem can be resolved using the PHAF.

  13. Control and signal processing by transcriptional interference

    Science.gov (United States)

    Buetti-Dinh, Antoine; Ungricht, Rosemarie; Kelemen, János Z; Shetty, Chetak; Ratna, Prasuna; Becskei, Attila

    2009-01-01

    A transcriptional activator can suppress gene expression by interfering with transcription initiated by another activator. Transcriptional interference has been increasingly recognized as a regulatory mechanism of gene expression. The signals received by the two antagonistically acting activators are combined by the polymerase trafficking along the DNA. We have designed a dual-control genetic system in yeast to explore this antagonism systematically. Antagonism by an upstream activator bears the hallmarks of competitive inhibition, whereas a downstream activator inhibits gene expression non-competitively. When gene expression is induced weakly, the antagonistic activator can have a positive effect and can even trigger paradoxical activation. Equilibrium and non-equilibrium models of transcription shed light on the mechanism by which interference converts signals, and reveals that self-antagonism of activators imitates the behavior of feed-forward loops. Indeed, a synthetic circuit generates a bell-shaped response, so that the induction of expression is limited to a narrow range of the input signal. The identification of conserved regulatory principles of interference will help to predict the transcriptional response of genes in their genomic context. PMID:19690569

  14. 47 CFR 27.64 - Protection from interference.

    Science.gov (United States)

    2010-10-01

    ... MISCELLANEOUS WIRELESS COMMUNICATIONS SERVICES Technical Standards § 27.64 Protection from interference. Wireless Communications Service (WCS) stations operating in full accordance with applicable FCC rules and... provided against interference caused by tropospheric and ionospheric propagation of signals....

  15. Quantum Interference of Multiple Beams Induced by Multiple Scattering

    DEFF Research Database (Denmark)

    Ott, Johan Raunkjær; Mortensen, N. Asger; Lodahl, Peter

    2011-01-01

    We report on quantum interference induced by the transmission of quantized light through a multiple-scattering medium. We show that entangled states can be created by multiple-scattering and that quantum interference survives disorder averaging.......We report on quantum interference induced by the transmission of quantized light through a multiple-scattering medium. We show that entangled states can be created by multiple-scattering and that quantum interference survives disorder averaging....

  16. Adjacent Band Interference from San Diego Area Transmitters to Goldstone Deep Space Network Receivers Near 2300 Megahertz

    Science.gov (United States)

    Ho, C.; Bathker, D.; Sue, M.; Peng, T.

    2001-10-01

    The Federal Communications Commission (FCC) has recently granted a commercial company a license to potentially deploy its wireless Internet system in the San Diego area in the 2300- to 2305-MHz frequency range. Each of several base station emitters would transmit a relatively strong effective isotropic radiated power (EIRP) (about 50 W). The frequency band is immediately above the band (2290 to 2300 MHz) used by NASA Deep Space Network (DSN) receiving stations at Goldstone, California. A potential interference problem to DSN receivers thus exists through some anomalous propagation modes, such as tropospheric ducting and rain scattering, and interference must be kept under a very small percentage of time (0.001 percent), as required by NASA deep-space missions. In this article, we have estimated the effects of interference from the wireless Internet system to Goldstone receivers. The calculation results show that at 2300 MHz the interference received by the DSN could exceed the DSN protection level up to 0.1 percent of the time for ducting propagation. For rain scattering, this could occur up to 2.3 percent of the time. At 2290 MHz, due to the transmitter spectrum, interference through either mode is below the DSN protection level. Interference through terrain diffraction will suffer very large attenuations at both frequencies. After considering that in the middle of the path there is a tall mountain peak that largely blocks the surface ducting and direct illumination of rain clouds, the interference generated by the wireless system emitters and propagated

  17. Recommendations for the design of interference probes for the simultaneous measurement of turbulent concentration and velocity

    Science.gov (United States)

    Hewes, Alaïs; Mydlarski, Laurent

    2016-11-01

    The present work focuses on the design and optimization of a thermal-anemometry-based interference probe used to simultaneously measure concentration and velocity at relatively high temporal and spatial resolutions in turbulent flows. Although a small number of similar measurements have been successfully performed, little work has been undertaken to investigate the design of such specialized probes, in which one hot-wire sensor is operated downstream of, and micrometers from, a second one. To this end, experiments performed in the non-buoyant region of a helium-air jet were undertaken to study the effects of overheat ratios, wire separation distances, wire diameters, and wire materials on the performance of interference probes. They revealed that accurate concentration and velocity measurements require that an interference probe have two wires of differing diameters with a small separation, of about 10 μm, between the wires. Furthermore, the upstream wire should be operated at a high overheat ratio and the downstream wire at a low one. An optimal design for an interference probe is presented, and measurements made in a turbulent jet are used to benchmark its accuracy. Supported by the Natural Sciences and Engineering Research Council of Canada (Grant 217184).

  18. Vibration interference analysis and verification of micro-fluidic inertial switch

    Directory of Open Access Journals (Sweden)

    Liu Tingting

    2014-02-01

    Full Text Available The micro-fluidic inertial switch based on liquid metal utilizes the moving mercury droplet to close the switch under the action of acceleration, which is characterized by no moving parts, small contact resistance, long service life and large current. In addition to the requirement of response time, accuracy and reliability, the micro-fluidic inertial switch needs to overcome the impact of the ambient vibration. The influence of the ambient vibration on the performance of switch is investigated by loading pulse or sinusoidal interference signals in the X, Y and Z direction. The numerical results suggest that the performance of micro-fluidic inertial switch is greatly affected by impact interference signal in X sensitive direction as compared with low frequency harmonic signal. If the impact signal with high amplitude lasts only for a short time, the wrong operation might also occur. The interference signals in insensitive direction have a relatively small impact on the performance of switch, and the impact of interference signal can be reduced by reasonable structural design. Finally, anodic bonding, deep reactive ion etching (DRIE and sputtering technique are adopted to fabricate the micro-fluidic inertial switch. The acceleration threshold of the prototype is tested. The experiment results agree with the numerical results, which indicate that the simulation method is valid.

  19. Vibration interference analysis and verification of micro-fluidic inertial switch

    Science.gov (United States)

    Tingting, Liu; Wei, Su; Tao, Yang; Yuan, Xu

    2014-03-01

    The micro-fluidic inertial switch based on liquid metal utilizes the moving mercury droplet to close the switch under the action of acceleration, which is characterized by no moving parts, small contact resistance, long service life and large current. In addition to the requirement of response time, accuracy and reliability, the micro-fluidic inertial switch needs to overcome the impact of the ambient vibration. The influence of the ambient vibration on the performance of switch is investigated by loading pulse or sinusoidal interference signals in the X, Y and Z direction. The numerical results suggest that the performance of micro-fluidic inertial switch is greatly affected by impact interference signal in X sensitive direction as compared with low frequency harmonic signal. If the impact signal with high amplitude lasts only for a short time, the wrong operation might also occur. The interference signals in insensitive direction have a relatively small impact on the performance of switch, and the impact of interference signal can be reduced by reasonable structural design. Finally, anodic bonding, deep reactive ion etching (DRIE) and sputtering technique are adopted to fabricate the micro-fluidic inertial switch. The acceleration threshold of the prototype is tested. The experiment results agree with the numerical results, which indicate that the simulation method is valid.

  20. RNA Interference as a Therapeutic Strategy for the Treatment of Liver Diseases.

    Science.gov (United States)

    Gonzalez-Rodriguez, Agueda; Valverde, Angela M

    2015-01-01

    RNA interference has emerged as an innovative technology for gene silencing that degrades mRNAs complementary to the antisense strands of double-stranded, short interfering RNAs (siRNAs). Its therapeutic application has important advantages over small-molecule drugs since offers the possibility of targeting virtually all genes and allows selective silencing of one or several genes. So far, a relative small proportion of cellular proteins can bind and respond to chemical drugs. Based on that, RNA interference-mediated gene silencing is widely considered as a crucial breakthrough in molecular biology with a direct translation to medicine. The liver has been widely chosen as a model system for the development of RNA interference therapy due to the convenience and availability of effective delivery into this tissue. Numerous preclinical models have revealed promising results, but the safety of this technology remains the primary challenge in developing siRNA based treatments. Liver diseases comprise a broad spectrum of genetic and non-genetic pathologies including acute fulminant liver injury that demands urgent medical care, or chronic pathologies such as nonalcoholic fatty liver (NAFLD), alcoholic liver disease, liver cirrhosis, viral hepatitis and hepatocellular carcinoma (HCC). In some cases restoration of liver function is not possible and alternatives to liver transplantation offering novel and efficient therapeutic approaches are urgently needed. In this review, we describe recent insights on the advantages of using RNA interference in preclinical settings as a targeted strategy with potential to markedly improve the treatment of liver diseases.

  1. Capacity Regions and Sum-Rate Capacities of Vector Gaussian Interference Channels

    CERN Document Server

    Shang, Xiaohu; Kramer, Gerhard; Poor, H Vincent

    2009-01-01

    The capacity regions of vector, or multiple-input multiple-output, Gaussian interference channels are established for very strong interference and aligned strong interference. Furthermore, the sum-rate capacities are established for Z interference, noisy interference, and mixed (aligned weak/intermediate and aligned strong) interference. These results generalize known results for scalar Gaussian interference channels.

  2. An RF interference mitigation methodology with potential applications in scheduling

    Science.gov (United States)

    Wong, Yen F.; Rash, James L.

    1991-01-01

    Software tools for interference analysis and mitigation were developed in the Communications Link Analysis and Simulation System (CLASS) environment for: communications performance evaluation; and mission planning. Potential applications are seen in analysis, evaluation, and optimization of user schedules. Tools producing required separation angles and potential interference intervals can be used as an aid to mutual interference mitigation within a scheduling system.

  3. Bimanual Interference Associated with Handling Different Tool Transformations

    Science.gov (United States)

    Massen, Cristina; Sattler, Christine

    2013-01-01

    Research on bimanual coordination of hand movements has identified several loci of bimanual interference, including interference because of programming different movement parameters or selecting different targets for the two hands. This study investigates the extent and origin of interference when participants execute bimanual actions with tools.…

  4. Visualizing the Solute Vaporization Interference in Flame Atomic Absorption Spectroscopy

    Science.gov (United States)

    Dockery, Christopher R.; Blew, Michael J.; Goode, Scott R.

    2008-01-01

    Every day, tens of thousands of chemists use analytical atomic spectroscopy in their work, often without knowledge of possible interferences. We present a unique approach to study these interferences by using modern response surface methods to visualize an interference in which aluminum depresses the calcium atomic absorption signal. Calcium…

  5. Addressing Cultural and Native Language Interference in Second Language Acquisition

    Science.gov (United States)

    Allard, Daniele; Bourdeau, Jacqueline; Mizoguchi, Riichiro

    2011-01-01

    This paper addresses the problem of cultural and native language interference in second/foreign language acquisition. More specifically, it examines issues of interference that can be traced to a student's native language and that also have a cultural component. To this effect, an understanding of what actually comprises both interference and…

  6. Addressing Cultural and Native Language Interference in Second Language Acquisition

    Science.gov (United States)

    Allard, Daniele; Bourdeau, Jacqueline; Mizoguchi, Riichiro

    2011-01-01

    This paper addresses the problem of cultural and native language interference in second/foreign language acquisition. More specifically, it examines issues of interference that can be traced to a student's native language and that also have a cultural component. To this effect, an understanding of what actually comprises both interference and…

  7. A follow-up study of electromagnetic interference of cellular phones on electronic medical equipment in the emergency department.

    Science.gov (United States)

    Fung, Hin Tat; Kam, Chak Wah; Yau, Hon Hung

    2002-09-01

    Considering the growing use of cellular phones and the fast appearance of new phone models, the electromagnetic interference of currently popular cellular phones on electronic medical equipment was tested. Three Personal Communication System cellular phones were put at different distances from multiple electronic medical devices, the interference effect was observed and the electromagnetic field strength measured with a spectrum analyser. Only two small pieces of equipment, the CO2 airway adapter and the haemoglucostix meter were affected and then only when the phone was in very close proximity. Compared to the results of our study in 1997 testing Global System for Mobile Communication phones, the Personal Communication System phones generated less electromagnetic interference. However a much larger scaled study and an accurate international electromagnetic interference standard are recommended before any change in the current restrictive hospital policy on mobile phone usage could be recommended.

  8. Role of RNA interference (RNAi) in the moss Physcomitrella patens

    KAUST Repository

    Arif, Muhammad Asif

    2013-01-14

    RNA interference (RNAi) is a mechanism that regulates genes by either transcriptional (TGS) or posttranscriptional gene silencing (PTGS), required for genome maintenance and proper development of an organism. Small non-coding RNAs are the key players in RNAi and have been intensively studied in eukaryotes. In plants, several classes of small RNAs with specific sizes and dedicated functions have evolved. The major classes of small RNAs include microRNAs (miRNAs) and small interfering RNAs (siRNAs), which differ in their biogenesis. miRNAs are synthesized from a short hairpin structure while siRNAs are derived from long double-stranded RNAs (dsRNA). Both miRNA and siRNAs control the expression of cognate target RNAs by binding to reverse complementary sequences mediating cleavage or translational inhibition of the target RNA. They also act on the DNA and cause epigenetic changes such as DNA methylation and histone modifications. In the last years, the analysis of plant RNAi pathways was extended to the bryophyte Physcomitrella patens, a non-flowering, non-vascular ancient land plant that diverged from the lineage of seed plants approximately 450 million years ago. Based on a number of characteristic features and its phylogenetic key position in land plant evolution P. patens emerged as a plant model species to address basic as well as applied topics in plant biology. Here we summarize the current knowledge on the role of RNAi in P. patens that shows functional overlap with RNAi pathways from seed plants, and also unique features specific to this species. 2013 by the authors; licensee MDPI, Basel, Switzerland.

  9. Role of RNA Interference (RNAi in the Moss Physcomitrella patens

    Directory of Open Access Journals (Sweden)

    Basel Khraiwesh

    2013-01-01

    Full Text Available RNA interference (RNAi is a mechanism that regulates genes by either transcriptional (TGS or posttranscriptional gene silencing (PTGS, required for genome maintenance and proper development of an organism. Small non-coding RNAs are the key players in RNAi and have been intensively studied in eukaryotes. In plants, several classes of small RNAs with specific sizes and dedicated functions have evolved. The major classes of small RNAs include microRNAs (miRNAs and small interfering RNAs (siRNAs, which differ in their biogenesis. miRNAs are synthesized from a short hairpin structure while siRNAs are derived from long double-stranded RNAs (dsRNA. Both miRNA and siRNAs control the expression of cognate target RNAs by binding to reverse complementary sequences mediating cleavage or translational inhibition of the target RNA. They also act on the DNA and cause epigenetic changes such as DNA methylation and histone modifications. In the last years, the analysis of plant RNAi pathways was extended to the bryophyte Physcomitrella patens, a non-flowering, non-vascular ancient land plant that diverged from the lineage of seed plants approximately 450 million years ago. Based on a number of characteristic features and its phylogenetic key position in land plant evolution P. patens emerged as a plant model species to address basic as well as applied topics in plant biology. Here we summarize the current knowledge on the role of RNAi in P. patens that shows functional overlap with RNAi pathways from seed plants, and also unique features specific to this species.

  10. Contribution of electric quadrupole and dipole-quadrupole interference terms in Coulomb breakup of 15C

    Science.gov (United States)

    Singh, P.; Kharb, S.; Singh, M.

    2014-02-01

    The effects of electric quadrupole ( E2) and dipole-quadrupole interference ( E1- E2) terms in the Coulomb breakup of 15C have been investigated within the framework of eikonal approximation. The sensitivity of Coulomb breakup cross section, differential in relative energy and Longitudinal Momentum Distribution (LMD) of core fragments, towards these terms have been examined. A very small (1% of E1) contribution of E2 transition has been predicted in integrated Coulomb breakup cross section. Further it is also found that the inclusion of E2 and E1- E2 terms introduces a small asymmetry in the peak of relative energy spectrum and also increases the peak height of the spectrum. The contribution of dipole-quadrupole interference terms is clearly shown in LMD, as it introduces an asymmetry in the shape of LMD and enhances the matching between the data and predictions.

  11. Transient interference of transmission and incidence

    CERN Document Server

    Pérez-Prieto, A L; Muga, J G

    2000-01-01

    Due to a transient quantum interference during a wavepacket collision with a potential barrier, a particular momentum, that depends on the potential parameters but is close to the initial average momentum, becomes suppressed. The hole left pushes the momentum distribution outwards leading to a significant constructive enhancement of lower and higher momenta. This is explained in the momentum complex-plane language in terms of a saddle point and two contiguous ``structural'' poles, which are not associated with resonances but with incident and transmitted components of the wavefunction.

  12. Multipolar interference for directed light emission.

    Science.gov (United States)

    Hancu, Ion M; Curto, Alberto G; Castro-López, Marta; Kuttge, Martin; van Hulst, Niek F

    2014-01-08

    By directing light, optical antennas can enhance light-matter interaction and improve the efficiency of nanophotonic devices. Here we exploit the interference among the electric dipole, quadrupole, and magnetic dipole moments of a split-ring resonator to experimentally realize a compact directional optical antenna. This single-element antenna design robustly directs emission even when covered with nanometric emitters at random positions, outperforming previously demonstrated nanoantennas with a bandwidth of 200 nm and a directivity of 10.1 dB from a subwavelength structure. The advantages of this approach bring directional optical antennas closer to practical applications.

  13. Angular momentum sensitive two-center interference.

    Science.gov (United States)

    Ilchen, M; Glaser, L; Scholz, F; Walter, P; Deinert, S; Rothkirch, A; Seltmann, J; Viefhaus, J; Decleva, P; Langer, B; Knie, A; Ehresmann, A; Al-Dossary, O M; Braune, M; Hartmann, G; Meissner, A; Tribedi, L C; AlKhaldi, M; Becker, U

    2014-01-17

    In quantum mechanics the Young-type double-slit experiment can be performed with electrons either traveling through a double slit or being coherently emitted from two inversion symmetric molecular sites. In the latter one the valence photoionization cross sections of homonuclear diatomic molecules were predicted to oscillate over kinetic energy almost 50 years ago. Beyond the direct proof of the oscillatory behavior of these photoionization cross sections σ, we show that the angular distribution of the emitted electrons reveals hitherto unexplored information on the relative phase shift between the corresponding partial waves through two-center interference patterns.

  14. Angular Momentum Sensitive Two-Center Interference

    Science.gov (United States)

    Ilchen, M.; Glaser, L.; Scholz, F.; Walter, P.; Deinert, S.; Rothkirch, A.; Seltmann, J.; Viefhaus, J.; Decleva, P.; Langer, B.; Knie, A.; Ehresmann, A.; Al-Dossary, O. M.; Braune, M.; Hartmann, G.; Meissner, A.; Tribedi, L. C.; AlKhaldi, M.; Becker, U.

    2014-01-01

    In quantum mechanics the Young-type double-slit experiment can be performed with electrons either traveling through a double slit or being coherently emitted from two inversion symmetric molecular sites. In the latter one the valence photoionization cross sections of homonuclear diatomic molecules were predicted to oscillate over kinetic energy almost 50 years ago. Beyond the direct proof of the oscillatory behavior of these photoionization cross sections σ, we show that the angular distribution of the emitted electrons reveals hitherto unexplored information on the relative phase shift between the corresponding partial waves through two-center interference patterns.

  15. Stroop interference in adults with dyslexia.

    Science.gov (United States)

    Proulx, Michael J; Elmasry, Hannah-May

    2015-01-01

    Prior research on developmental dyslexia using Stroop tasks with young participants has found increased interference in participants with dyslexia relative to controls. Here we extend these findings to adult participants, and introduce a novel test of Stroop incongruity, whereby the color names appeared on an object colored in the incongruent color. The results imply that impaired inhibitory and executive attentional mechanisms are still deficient in adults with dyslexia and that other forms of attentional mechanisms, such as object-based attention, might also be impaired in dyslexia. Dyslexia arises not only from deficits in phonological processing, but from attentional mechanisms as well.

  16. Interference Alignment in Dense Wireless Networks

    CERN Document Server

    Niesen, Urs

    2009-01-01

    We consider arbitrary dense wireless networks, in which $n$ nodes are placed in an arbitrary (deterministic) manner on a square region of unit area and communicate with each other over Gaussian fading channels. We provide inner and outer bounds for the $n\\times n$-dimensional unicast and the $n\\times 2^n$-dimensional multicast capacity regions of such a wireless network. These inner and outer bounds differ only by a factor $O(\\log(n))$, yielding a fairly tight scaling characterization of the entire regions. The communication schemes achieving the inner bounds use interference alignment as a central technique and are surprisingly simple.

  17. Quantum Radiation Reaction: From Interference to Incoherence.

    Science.gov (United States)

    Dinu, Victor; Harvey, Chris; Ilderton, Anton; Marklund, Mattias; Torgrimsson, Greger

    2016-01-29

    We investigate quantum radiation reaction in laser-electron interactions across different energy and intensity regimes. Using a fully quantum approach which also accounts exactly for the effect of the strong laser pulse on the electron motion, we identify in particular a regime in which radiation reaction is dominated by quantum interference. We find signatures of quantum radiation reaction in the electron spectra which have no classical analogue and which cannot be captured by the incoherent approximations typically used in the high-intensity regime. These signatures are measurable with presently available laser and accelerator technology.

  18. Quantum radiation reaction: from interference to incoherence

    CERN Document Server

    Dinu, Victor; Ilderton, Anton; Marklund, Mattias; Torgrimsson, Greger

    2015-01-01

    We investigate quantum radiation reaction in laser-electron interactions across different energy and intensity regimes. Using a fully quantum approach which also accounts exactly for the effect of the strong laser pulse on the electron motion, we identify in particular a regime in which radiation reaction is dominated by quantum interference. We find signatures of quantum radiation reaction in the electron spectra which have no classical analogue and which cannot be captured by the incoherent approximations typically used in the high-intensity regime. These signatures are measurable with presently available laser and accelerator technology.

  19. Radio Frequency Interference Mitigation at the WSRT

    CERN Document Server

    Fridman, P A; Millenaar, R P

    2010-01-01

    The sensitivity of radio astronomical stations is often limited by man-made radio frequency interference (RFI) due to a variety of terrestrial activities. An RFI mitigation subsystem (RFIMS) based on real-time digital signalprocessing is proposed here for the Westerbork Synthesis Radio Telescope based on a powerful field programmable gate array processor. In this system the radio astronomy signals polluted by RFI are "cleaned" with the RFIMS before routine back-end correlation processing takes place. The high temporal and frequency resolution of RFIMS allows the detection and excision of RFI better than do standard radio telescope back-end configurations.

  20. Interference Tests at Kawerau, New Zealand

    Energy Technology Data Exchange (ETDEWEB)

    Burnell, John G.; McGuinness, Mark J.

    1987-01-20

    Analysis of interference tests at the Kawerau geothermal field in New Zealand has indicated that the reservoir may be viewed on a coarse scale as a two-layer structure. While these layers have high permeabilities, they are in poor hydrological communication with each other. The shallower layer is modelled as a finite cylindrical reservoir. The deeper layer is modelled as a larger cylindrical reservoir with recharge from the sides. The fitted permeabilities and storativities suggest the importance of flow in fractures at Kawerau. 2 tabs., 14 figs., 8 refs.

  1. Preserved cumulative semantic interference despite amnesia

    Directory of Open Access Journals (Sweden)

    Gary Michael Oppenheim

    2015-05-01

    As predicted by Oppenheim et al’s (2010 implicit incremental learning account, WRP’s BCN RTs demonstrated strong (and significant repetition priming and semantic blocking effects (Figure 1. Similar to typical results from neurally intact undergraduates, WRP took longer to name pictures presented in semantically homogeneous blocks than in heterogeneous blocks, an effect that increased with each cycle. This result challenges accounts that ascribe cumulative semantic interference in this task to explicit memory mechanisms, instead suggesting that the effect has the sort of implicit learning bases that are typically spared in hippocampal amnesia.

  2. RNA interference and its application in plants

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    RNA interference (RNAi), a process that inhibits gene expression by the double-stranded RNA (dsRNA), causes the deg-radation of target messenger RNA molecules. RNAi exists in almost all organisms. We review the recent history of RNAi studies,RNAi molecular mechanisms, characteristics and RNAi applications in higher plants. At the same time, the prospect of RNAi appli-cations in functional genomics and genetic improvement of higher plants and possible future problems and possibilities are also dis-cussed.

  3. Improved Interference configuration for structured illumination microscopy

    Science.gov (United States)

    Chen, Houkai; Wei, Shibiao; Wu, Xiaojing; Yang, Yong; Zhang, Yuquan; Du, Luping; Liu, Jun; Zhu, Siwei; Yuan, Xiaocong

    2017-02-01

    We present an improved structured illumination configuration for structured illumination microscopy (SIM) based on spatial light modulator. Precise phase shifts and rotation of illumination fringes can be dynamically controlled using a spatial light modulator. The method is different from the conventional illumination configuration that are based on interference of ±1 diffractive order light. The experimental setup requires less optical elements making it compact, reliable, and suitable for integration. The method has been applied in the standing-wave total internal reflection fluorescent microscopy. High lateral resolution of sub-100 nm was achieved in single directional resolution enhancement experiments.

  4. Review Results on Wing-Body Interference

    OpenAIRE

    Frolov Vladimir

    2016-01-01

    The paper presents an overview of results for wing-body interference, obtained by the author for varied wing-body combinations. The lift-curve slopes of the wing-body combinations are considered. In this paper a discrete vortices method (DVM) and 2D potential model for cross-flow around fuselage are used. The circular and elliptical cross-sections of the fuselage and flat wings of various forms are considered. Calculations showed that the value of the lift-curve slopes of the wing-body combin...

  5. Auditory list memory and interference processes in monkeys.

    Science.gov (United States)

    Wright, A A

    1999-07-01

    Memory of 2 rhesus monkeys (Macaca mulatta) was tested in a serial probe recognition task with lists of 4 natural or environmental sounds, different retention intervals, and different manipulations of interference. At short retention intervals, increasing the separation of list items reduced the primacy effect and produced a recency effect. Similar results were shown by increasing interference across lists through item repetitions or making the first 2 list items high-interference items. These results indicated that decreasing first-item performance reduced proactive interference on memory of the last list items. At long (20 s) retention intervals, making the last list items of high interference reduced the recency effect, reduced retroactive interference, and produced a primacy effect. Taken together, interference plays a role in determining the primacy and recency effects of the serial-position function.

  6. Italian, French, Polish: in the Bermuda Triangle of linguistic interference

    Directory of Open Access Journals (Sweden)

    Małgorzata Balicka

    2009-01-01

    Full Text Available Increasing contacts between nations make people learn foreign languages. Unfortunately, the use of more than one language system may cause errors due to linguistic interference. In the present paper we consider different definitions of this phenomenon and describe the conditions reąuired for its presence, along with proposals on how to eliminate interference mistakes. A specific case is false friends, words similar in form but different in meaning, which can lead to misunderstandings or even disgrace. As interference implies the knowledge of at least two languages, bilingualism is another problem discussed in the paper. We present different approaches to interference and study the relation between bilingualism and interference. Finally, we discuss loanwords as one of the results of interference. With all these considerations in mind we can make a specific study of interference mistakes made by Polish students of Italian philology.

  7. Reliability Estimations of Control Systems Effected by Several Interference Sources

    Institute of Scientific and Technical Information of China (English)

    Deng Bei-xing; Jiang Ming-hu; Li Xing

    2003-01-01

    In order to estab lish the sufficient and necessary condition that arbitrarily reliable systems can not be construc-ted with function elements under interference sources, it is very important to expand set of interference sources with the above property. In this paper, the models of two types of in-terference sources are raised respectively: interference source possessing real input vectors and constant reliable interference source. We study the reliability of the systems effected by the interference sources, and the lower bound of the reliability is presented. The results show that it is impossible that arbi-trarily reliable systems can not be constructed with the ele-ments effected by above interference sources.

  8. Strong Correlation of Fluorescence Photons without Quantum Interference

    Institute of Scientific and Technical Information of China (English)

    HU Xiang-Ming; WANG Fei

    2007-01-01

    It has been predicted that a driven three-level V atom can emit strongly correlated fluorescence photons in the presence of quantum interference. Here we examine the effects of quantum interference on the intensity correlation of fluorescence photons emitted from a driven three-level A atom. Unexpectedly, strong correlation occurs without quantum interference. The quantum interference tends to reduce the correlation function to a normal level. The essential difference between these two cases is traced to the different effects of quantum interference on coherent population trapping (CPT). For the V atom, quantum interference and coherent excitation combine to lead to CPT. For the A atom, however, the quantum interference tends to spoil CPT while the coherent excitation induces the effect.

  9. Multicast in Femtocell Networks: A Successive Interference Cancellation Approach

    Directory of Open Access Journals (Sweden)

    Donglin Hu

    2014-09-01

    Full Text Available A femtocell is a small cellular base station (BS, typically used for serving approved users within a small coverage. In this paper, we investigate the problem of data multicast in femtocell networks that incorporates superposition coding (SC and successive interference cancellation (SIC. The problem is to decide the transmission schedule for each BS, as well as the power allocation for the SC layers, to achieve a sufficiently large SNR for each layer to be decodable with SIC at each user. Minimizing the total BS power consumption achieves the goal of “green” communications. We formulate a Mixed Integer Nonlinear Programming (MINLP problem, and then reformulate the problem into a simpler form. Upper and lower performance bounds on the total BS power consumption are derived. Finally, we consider three typical connection scenarios, and develop optimal and nearoptimal algorithms for the three scenarios. The proposed algorithms have low computational complexity, and outperform a heuristic scheme with considerable gains in our simulation study.

  10. Inhibition of Monkeypox virus replication by RNA interference

    Directory of Open Access Journals (Sweden)

    Jahrling Peter B

    2009-11-01

    Full Text Available Abstract The Orthopoxvirus genus of Poxviridae family is comprised of several human pathogens, including cowpox (CPXV, Vaccinia (VACV, monkeypox (MPV and Variola (VARV viruses. Species of this virus genus cause human diseases with various severities and outcome ranging from mild conditions to death in fulminating cases. Currently, vaccination is the only protective measure against infection with these viruses and no licensed antiviral drug therapy is available. In this study, we investigated the potential of RNA interference pathway (RNAi as a therapeutic approach for orthopox virus infections using MPV as a model. Based on genome-wide expression studies and bioinformatic analysis, we selected 12 viral genes and targeted them by small interference RNA (siRNA. Forty-eight siRNA constructs were developed and evaluated in vitro for their ability to inhibit viral replication. Two genes, each targeted with four different siRNA constructs in one pool, were limiting to viral replication. Seven siRNA constructs from these two pools, targeting either an essential gene for viral replication (A6R or an important gene in viral entry (E8L, inhibited viral replication in cell culture by 65-95% with no apparent cytotoxicity. Further analysis with wild-type and recombinant MPV expressing green fluorescence protein demonstrated that one of these constructs, siA6-a, was the most potent and inhibited viral replication for up to 7 days at a concentration of 10 nM. These results emphasis the essential role of A6R gene in viral replication, and demonstrate the potential of RNAi as a therapeutic approach for developing oligonucleotide-based drug therapy for MPV and other orthopox viruses.

  11. Aligned Interference Neutralization and the Degrees of Freedom of the 2x2x2 Interference Channel

    CERN Document Server

    Gou, Tiangao; Jeon, Sang-Woon; Chung, Sae-Young

    2010-01-01

    We show that the 2x2x2 interference channel, i.e., the multihop interference channel formed by concatenation of two 2-user interference channels achieves the min-cut outer bound value of 2 DoF, for almost all values of channel coefficients, for both time-varying or fixed channel coefficients. The key to this result is a new idea, called aligned interference neutralization, that provides a way to align interference terms over each hop in a manner that allows them to be cancelled over the air at the last hop.

  12. Occupational stress, work-home interference and burnout among Belgian veterinary practitioners

    Directory of Open Access Journals (Sweden)

    Hansez I

    2008-04-01

    Full Text Available Abstract There have been few formal studies on stress in veterinary surgeons and, in the rare studies available, stress is not examined jointly through the levels of job strain and job engagement, the sources of stress in the issue of work environment and the work-home interference. The authors' goal in this study was to analyse job engagement, job strain, burnout, work-home interference and job stress factors among 216 Belgian veterinary surgeons. Rural practice was compared to small animal and mixed activity. The mean job strain and job engagement level in veterinary surgeons was not higher than what we found in other working populations. However, 15.6% of the group were found to be suffering from high burnout. Rural practitioners had a lower level of job engagement than small animal veterinary surgeons. These small animal practitioners had a lower level of job strain than the mixed practitioners. The level of burnout did not differ significantly across the three types of activity. In comparison to other Belgian and Dutch workers, veterinary surgeons perceived more negative work-home interference. Bovine and mixed practitioners were the most concerned with this problem. The two most important sources of stress reported by bovine practitioners were relations to farmers and working time management (including emergencies and availability.

  13. Occupational stress, work-home interference and burnout among Belgian veterinary practitioners

    Science.gov (United States)

    2008-01-01

    There have been few formal studies on stress in veterinary surgeons and, in the rare studies available, stress is not examined jointly through the levels of job strain and job engagement, the sources of stress in the issue of work environment and the work-home interference. The authors' goal in this study was to analyse job engagement, job strain, burnout, work-home interference and job stress factors among 216 Belgian veterinary surgeons. Rural practice was compared to small animal and mixed activity. The mean job strain and job engagement level in veterinary surgeons was not higher than what we found in other working populations. However, 15.6% of the group were found to be suffering from high burnout. Rural practitioners had a lower level of job engagement than small animal veterinary surgeons. These small animal practitioners had a lower level of job strain than the mixed practitioners. The level of burnout did not differ significantly across the three types of activity. In comparison to other Belgian and Dutch workers, veterinary surgeons perceived more negative work-home interference. Bovine and mixed practitioners were the most concerned with this problem. The two most important sources of stress reported by bovine practitioners were relations to farmers and working time management (including emergencies and availability). PMID:21851711

  14. Quantum interference in an interfacial superconductor

    Science.gov (United States)

    Goswami, Srijit; Mulazimoglu, Emre; Monteiro, Ana M. R. V. L.; Wölbing, Roman; Koelle, Dieter; Kleiner, Reinhold; Blanter, Ya. M.; Vandersypen, Lieven M. K.; Caviglia, Andrea D.

    2016-10-01

    The two-dimensional superconductor that forms at the interface between the complex oxides lanthanum aluminate (LAO) and strontium titanate (STO) has several intriguing properties that set it apart from conventional superconductors. Most notably, an electric field can be used to tune its critical temperature (Tc; ref. 7), revealing a dome-shaped phase diagram reminiscent of high-Tc superconductors. So far, experiments with oxide interfaces have measured quantities that probe only the magnitude of the superconducting order parameter and are not sensitive to its phase. Here, we perform phase-sensitive measurements by realizing the first superconducting quantum interference devices (SQUIDs) at the LAO/STO interface. Furthermore, we develop a new paradigm for the creation of superconducting circuit elements, where local gates enable the in situ creation and control of Josephson junctions. These gate-defined SQUIDs are unique in that the entire device is made from a single superconductor with purely electrostatic interfaces between the superconducting reservoir and the weak link. We complement our experiments with numerical simulations and show that the low superfluid density of this interfacial superconductor results in a large, gate-controllable kinetic inductance of the SQUID. Our observation of robust quantum interference opens up a new pathway to understanding the nature of superconductivity at oxide interfaces.

  15. Absence of auditory 'global interference' in autism.

    Science.gov (United States)

    Foxton, Jessica M; Stewart, Mary E; Barnard, Louise; Rodgers, Jacqui; Young, Allan H; O'Brien, Gregory; Griffiths, Timothy D

    2003-12-01

    There has been considerable recent interest in the cognitive style of individuals with Autism Spectrum Disorder (ASD). One theory, that of weak central coherence, concerns an inability to combine stimulus details into a coherent whole. Here we test this theory in the case of sound patterns, using a new definition of the details (local structure) and the coherent whole (global structure). Thirteen individuals with a diagnosis of autism or Asperger's syndrome and 15 control participants were administered auditory tests, where they were required to match local pitch direction changes between two auditory sequences. When the other local features of the sequence pairs were altered (the actual pitches and relative time points of pitch direction change), the control participants obtained lower scores compared with when these details were left unchanged. This can be attributed to interference from the global structure, defined as the combination of the local auditory details. In contrast, the participants with ASD did not obtain lower scores in the presence of such mismatches. This was attributed to the absence of interference from an auditory coherent whole. The results are consistent with the presence of abnormal interactions between local and global auditory perception in ASD.

  16. RNA interference: Antiviral weapon and beyond

    Institute of Scientific and Technical Information of China (English)

    Quan-Chu Wang; Qing-He Nie; Zhi-Hua Feng

    2003-01-01

    RNA interference (RNAi) is a remarkable type of gene regulation based on sequence-specific targeting and degradation of RNA. The term encompasses related pathways found in a broad range of eukaryotic organisms, including fungi, plants, and animals. RNA interference is part of a sophisticated network of interconnected pathways for cellular defense, RNA surveillance, and development and it may become a powerful tool to manipulate gene expression experimentally. RNAi technology is currently being evaluated not only as an extremely powerful instrument for functional genomic analyses, but also as a potentially useful method to develop specific dsRNA based gene-silencing therapeutics.Several laboratories have been interested in using RNAi to control viral infection and many reports in Nature and in Cell show that short interfering (si) RNAs can inhibit infection by HIV-1, polio and hepatitis C viruses in a sequence-specific manner. RNA-based strategies for gene inhibition in mammalian cells have recently been described, which offer the promise of antiviral therapy.

  17. Normalized GNSS interference pattern technique for altimetry.

    Science.gov (United States)

    Ribot, Miguel Angel; Kucwaj, Jean-Christophe; Botteron, Cyril; Reboul, Serge; Stienne, Georges; Leclère, Jérôme; Choquel, Jean-Bernard; Farine, Pierre-André; Benjelloun, Mohammed

    2014-06-11

    It is well known that reflected signals from Global Navigation Satellite Systems (GNSS) can be used for altimetry applications, such as monitoring of water levels and determining snow height. Due to the interference of these reflected signals and the motion of satellites in space, the signal-to-noise ratio (SNR) measured at the receiver slowly oscillates. The oscillation rate is proportional to the change in the propagation path difference between the direct and reflected signals, which depends on the satellite elevation angle. Assuming a known receiver position, it is possible to compute the distance between the antenna and the surface of reflection from the measured oscillation rate. This technique is usually known as the interference pattern technique (IPT). In this paper, we propose to normalize the measurements in order to derive an alternative model of the SNR variations. From this model, we define a maximum likelihood estimate of the antenna height that reduces the estimation time to a fraction of one period of the SNR variation. We also derive the Cramér-Rao lower bound for the IPT and use it to assess the sensitivity of different parameters to the estimation of the antenna height. Finally, we propose an experimental framework, and we use it to assess our approach with real GPS L1 C/A signals.

  18. Discrete interference modeling via boolean algebra.

    Science.gov (United States)

    Beckhoff, Gerhard

    2011-01-01

    Two types of boolean functions are considered, the locus function of n variables, and the interval function of ν = n - 1 variables. A 1-1 mapping is given that takes elements (cells) of the interval function to antidual pairs of elements in the locus function, and vice versa. A set of ν binary codewords representing the intervals are defined and used to generate the codewords of all genomic regions. Next a diallelic three-point system is reviewed in the light of boolean functions, which leads to redefining complete interference by a logic function. Together with the upper bound of noninterference already defined by a boolean function, it confines the region of interference. Extensions of these two functions to any finite number of ν are straightforward, but have been also made in terms of variables taken from the inclusion-exclusion principle (expressing "at least" and "exactly equal to" a decimal integer). Two coefficients of coincidence for systems with more than three loci are defined and discussed, one using the average of several individual coefficients and the other taking as coefficient a real number between zero and one. Finally, by way of a malfunction of the mod-2 addition, it is shown that a four-point system may produce two different functions, one of which exhibiting loss of a class of odd recombinants.

  19. CP violation: Dalitz interference, CPT and FSI

    CERN Document Server

    Nogueira, J H Alvarenga; Cavalcante, A B R; Frederico, T; Lourenço, O

    2015-01-01

    Resonances and final state interactions (FSI) play a role in the formation of CP violation (CPV) constrained by CPT invariance. We provide a general formulation of CPV including resonances and FSI starting from the CPT constraint. Our discussion is elaborated within a simple $B$ decay model with the $\\rho$ and $f_0(980)$ resonances plus a non resonant background including the $\\pi\\pi \\to KK$ coupled amplitude. We consider few illustrative examples to show the interference patterns appearing in the CP asymmetry, namely, that from the $\\rho$ resonance plus a non-resonant amplitude, and that from the interference of the $\\rho$ and $f_0(980)$ resonances. We perform the fit of the CP asymmetry for the charmless three-body $B^\\pm$ decay channel $B^{\\pm}\\to \\pi^{\\pm} \\pi^+\\pi^-$ and obtain as outcome the $B^{\\pm}\\to \\pi^{\\pm} K^+K^-$ for $\\pi\\pi$ channel asymmetry in the mass region below $1.6$~GeV in fair agreement with the new data LHCb data. Analogously, we also describe the CP asymmetry of the $B^\\pm\\to K^\\pm\\pi...

  20. Normalized GNSS Interference Pattern Technique for Altimetry

    Directory of Open Access Journals (Sweden)

    Miguel Angel Ribot

    2014-06-01

    Full Text Available It is well known that reflected signals from Global Navigation Satellite Systems (GNSS can be used for altimetry applications, such as monitoring of water levels and determining snow height. Due to the interference of these reflected signals and the motion of satellites in space, the signal-to-noise ratio (SNR measured at the receiver slowly oscillates. The oscillation rate is proportional to the change in the propagation path difference between the direct and reflected signals, which depends on the satellite elevation angle. Assuming a known receiver position, it is possible to compute the distance between the antenna and the surface of reflection from the measured oscillation rate. This technique is usually known as the interference pattern technique (IPT. In this paper, we propose to normalize the measurements in order to derive an alternative model of the SNR variations. From this model, we define a maximum likelihood estimate of the antenna height that reduces the estimation time to a fraction of one period of the SNR variation. We also derive the Cramér–Rao lower bound for the IPT and use it to assess the sensitivity of different parameters to the estimation of the antenna height. Finally, we propose an experimental framework, and we use it to assess our approach with real GPS L1 C/A signals.

  1. Phase-locked laser coherent interference

    Institute of Scientific and Technical Information of China (English)

    Jingjing Wang; Xiaobo Wang; Bo He; Liantuan Mao; Suotang Jia

    2011-01-01

    A method of locking the relative phase to provide stable constructive or destructive interference between the phase-modulated sidebands from a pair of phase modulators is demonstrated. It is discussed theoretically for optimal fringe visibility related to the phase noise from faulty system. After phase locking using the phase modulating and lock-in technique, the drift of the relative phase is focalized around ±0.0016 rad and the fringe visibility is restricted to 2×l0-4.%@@ A method of locking the relative phase to provide stable constructive or destructive interference between the phase-modulated sidebands from a pair of phase modulators is demonstrated.It is discussed theoretically for optimal fringe visibility related to the phase noise from faulty system.After phase locking using the vhase modulating and lock-in technique.the drift of the relative phase is focalized around±0.0016 rad and the fringe visibility is restricted to 2×10-4.

  2. Wave interference in Richtmyer-Meshkov flows

    Science.gov (United States)

    Stellingwerf, Robert F.; Pandian, Arun; Abarzhi, Snezhana

    2016-11-01

    While it is a conventional wisdom that the initial conditions determine the linear and nonlinear dynamics of the Richtmyer-Meshkov (RM) flows, the research in this area is focused primarily on the effects of the wavelength and amplitude of the interface perturbation. The information is hitherto largely ignored about the influences on the evolution of Richtmyer-Meshkov instability (RMI) of the relative phase of a multi-wave perturbation and the interference of the perturbation waves. In this work we report a detailed study of confluence of effects of the relative phase as well as amplitudes of the interfacial waves on the structure of bubbles and spikes that is formed at the RM unstable interface after the shock passage. We show that the phase and the wave interference are important factors of the dynamics, because they influence the RM flow qualitatively and quantitatively, including the symmetry of the interface, the morphology of spikes and bubbles, and the RMI growth. The work is supported by the US National Science Foundation.

  3. Interference Alignment: A one-sided approach

    CERN Document Server

    Ghauch, Hadi G

    2011-01-01

    Interference Alignment (IA) is the process of designing signals in such a way that they cast overlapping shadows at their unintended receivers, while remaining distinguishable at the intended ones. Our goal in this paper is to come up with an algorithm for IA that runs at the transmitters only (and is transparent to the receivers), that doesn't require channel reciprocity, and that alleviates the need to alternate between the forward and reverse network as is the case in Distributed IA (Gomadam, Cadambe, Jafar 08'), thereby inducing significant overhead in certain environments where the channel changes frequently. Most importantly, our effort is focused on ensuring that this one-sided approach does not degrade the performance of the system w.r.t. Distributed IA (since it cannot improve it). As a first step, we model the interference in each receiver's desired signal as a function of the transmitters' beamforming vectors. We then propose a simple steepest descent (SD) algorithm and use it to minimize the inter...

  4. Interference Alignment with Partially Coordinated Transmit Precoding

    CERN Document Server

    Yousafzai, Aimal Khan

    2011-01-01

    In this paper, we introduce an efficient interference alignment (IA) algorithm exploiting partially coordinated transmit precoding to improve the number of concurrent interference-free transmissions, i.e., the multiplexing gain, in multicell downlink. The proposed coordination model is such that each base-station simultaneously transmits to two users and each user is served by two base-stations. First, we show in a K-user system operating at the information theoretic upper bound of degrees of freedom (DOF), the generic IA is proper when $K \\leq 3$, whereas the proposed partially coordinated IA is proper when $K \\leq 5$. Then, we derive a non-iterative, i.e., one shot, IA algorithm for the proposed scheme when $K \\leq 5$. We show that for a given latency, the backhaul data rate requirement of the proposed method grows linearly with K. Monte-Carlo simulation results show that the proposed one-shot algorithm offers higher system throughput than the iterative IA at practical SNR levels.

  5. Relay self interference minimisation using tapped filter

    KAUST Repository

    Jazzar, Saleh

    2013-05-01

    In this paper we introduce a self interference (SI) estimation and minimisation technique for amplify and forward relays. Relays are used to help forward signals between a transmitter and a receiver. This helps increase the signal coverage and reduce the required transmitted signal power. One problem that faces relays communications is the leaked signal from the relay\\'s output to its input. This will cause an SI problem where the new received signal at the relay\\'s input will be added with the unwanted leaked signal from the relay\\'s output. A Solution is proposed in this paper to estimate and minimise this SI which is based upon using a tapped filter at the destination. To get the optimum weights for this tapped filter, some channel parameters must be estimated first. This is performed blindly at the destination without the need of any training. This channel parameter estimation method is named the blind-self-interference-channel-estimation (BSICE) method. The next step in the proposed solution is to estimate the tapped filter\\'s weights. This is performed by minimising the mean squared error (MSE) at the destination. This proposed method is named the MSE-Optimum Weight (MSE-OW) method. Simulation results are provided in this paper to verify the performance of BSICE and MSE-OW methods. © 2013 IEEE.

  6. New Interference Mechanism Controls Ultracold Chemistry

    Science.gov (United States)

    Kendrick, Brian K.; Hazra, Jisha; Balakrishnan, N.

    2016-05-01

    A newly discovered interference mechanism has been shown to control the outcome of ultracold chemical reactions. The mechanism originates from the unique properties associated with ultracold collisions, namely: (1) isotropic (s-wave) scattering and (2) an effective quantization of the scattering phase shift (which originates from the bound state structure of the molecule). These two properties can lead to maximum constructive or destructive interference between two interfering reaction pathways (such as exchange and non-exchange in systems with two or more identical nuclei). If the molecular system exhibits a conical intersection, then the associated geometric phase is shown to act as a ``quantum switch'' which can turn the reactivity on or off. Reaction rate coefficients for the O + OH --> H + O2 and H + H2, reactions are presented which explicitly demonstrate the effect. Experimentalists might exploit this new mechanism to control ultracold reactions by the application of external electric or magnetic fields or by the selection of a particular nuclear spin state. This work was supported in part by the LDRD program (Grant No. 20140309ER) at LANL (B.K.) and by NSF Grant PHY-1505557 (N.B.) and ARO MURI Grant No. W911NF-12-1-0476 (N.B.).

  7. Interference Channels with Rate-Limited Feedback

    CERN Document Server

    Vahid, Alireza; Avestimehr, Amir Salman

    2011-01-01

    We study the effect of rate-limited feedback on the capacity region of the two-user interference channel. We consider three different interference models: El Gamal-Costa deterministic model, the linear deterministic model, and the Gaussian model. For the first two models, we develop an achievable scheme that combines three techniques: Han-Kobayashi message splitting, quantize-and-binning, and partial decode-and-forward. We also derive new outer-bounds to show the optimality of our scheme under the linear deterministic model. For the Gaussian model, we establish outer-bounds on the capacity region with rate-limited feedback. Employing lattice codes and the ideas developed in the first two models, we also propose a transmission strategy for the Gaussian model. For symmetric channel gains, we prove that the gap between the achievable sum-rate of the proposed scheme and the outer-bound is bounded by a constant number of bits, independent of the channel gains.

  8. GNSS space-time interference mitigation and attitude determination in the presence of interference signals.

    Science.gov (United States)

    Daneshmand, Saeed; Jahromi, Ali Jafarnia; Broumandan, Ali; Lachapelle, Gérard

    2015-05-26

    The use of Space-Time Processing (STP) in Global Navigation Satellite System (GNSS) applications is gaining significant attention due to its effectiveness for both narrowband and wideband interference suppression. However, the resulting distortion and bias on the cross correlation functions due to space-time filtering is a major limitation of this technique. Employing the steering vector of the GNSS signals in the filter structure can significantly reduce the distortion on cross correlation functions and lead to more accurate pseudorange measurements. This paper proposes a two-stage interference mitigation approach in which the first stage estimates an interference-free subspace before the acquisition and tracking phases and projects all received signals into this subspace. The next stage estimates array attitude parameters based on detecting and employing GNSS signals that are less distorted due to the projection process. Attitude parameters enable the receiver to estimate the steering vector of each satellite signal and use it in the novel distortionless STP filter to significantly reduce distortion and maximize Signal-to-Noise Ratio (SNR). GPS signals were collected using a six-element antenna array under open sky conditions to first calibrate the antenna array. Simulated interfering signals were then added to the digitized samples in software to verify the applicability of the proposed receiver structure and assess its performance for several interference scenarios.

  9. On the Optimality of Opportunistic Interference Alignment in 3-Transmitter MIMO Interference Channels

    CERN Document Server

    Lee, Jung Hoon; Love, David J

    2011-01-01

    In this paper, we propose opportunistic interference alignment (OIA) for three-transmitter multiple-input multiple-output (MIMO) interference channels (ICs). In the proposed OIA scheme, each transmitter has its own user group that consists of $K$ users, and each transmitter opportunistically selects the user whose received interference signals are most aligned. Thus, three-transmitter MIMO IC is opportunistically constructed by three transmitters and their selected users. Contrary to conventional IA, perfect channel information for all of the interference links is not required at the transmitter. Each user just needs to feed back one scalar value in the proposed OIA scheme. When the number of receive antennas is $N_R$ (with $N_R=2M$) and the number of transmit antennas is $N_T$ (with $N_T\\ge M$), we prove that each transmitter can achieve $M$ degrees of freedom (DoF) as the number of users in each group goes to infinity ($K\\to\\infty$), in comparison with the $\\frac{2M}{3}$ DoF known to be achievable in the th...

  10. Degeneracy estimation in interference models on wireless networks

    Science.gov (United States)

    McBride, Neal; Bulava, John; Galiotto, Carlo; Marchetti, Nicola; Macaluso, Irene; Doyle, Linda

    2017-03-01

    We present a Monte Carlo study of interference in real-world wireless networks using the Potts model. Our approach maps the Potts energy to discrete interference levels. These levels depend on the configurations of radio frequency allocation in the network. For the first time, we estimate the degeneracy of these interference levels using the Wang-Landau algorithm. The cumulative distribution function of the resulting density of states is found to increase rapidly at a critical interference value. We compare these critical values for several different real-world interference networks and Potts models. Our results show that models with a greater number of available frequency channels and less dense interference networks result in the majority of configurations having lower interference levels. Consequently, their critical interference levels occur at lower values. Furthermore, the area under the density of states increases and shifts to lower interference values. Therefore, the probability of randomly sampling low interference configurations is higher under these conditions. This result can be used to consider dynamic and distributed spectrum allocation in future wireless networks.

  11. In-flight observations of electromagnetic interferences emitted by satellite

    Institute of Scientific and Technical Information of China (English)

    CAO JinBin; YANG JunYing; YUAN ShiGan; SHEN XuHui; LIU YuanMo; YAN ChunXiao; LI WenZhen; CHEN Tao

    2009-01-01

    Using the data from STAFF/TC-1, this paper for the first time analyzes the electromagnetic interferences of Chinese scientific satellite. The electromagnetic interference of satellite exists mainly below 30 Hz,but can extend to 190 Hz with an obviously decreasing power spectral density. The electromagnetic interferences at frequencies below 190 Hz have good correlation with the solar aspect angle. The electromagnetic interferences at frequencies between 190 and 830 Hz have also correlation with solar aspect angle. However, the electromagnetic interferences at frequencies above 830 Hz have no correlation with the solar aspect angle. The correlation coefficient between solar aspect angel and electromagnetic interferences is around 0.90. The larger the solar aspect angle, the stronger the satellite electromagnetic interference. When the solar aspect angle increases from 90.6° to 93.6°, the electromagnetic interferences at frequencies <10 Hz increase by 8 times and those at frequencies 190-830 Hz increase by 60%. This close association of electromagnetic interferences with the solar aspect angle indicates that the solar aspect angle is the main factor to determine the electromagnetic interferences.The electromagnetic interferences of satellite in sunlight are larger than those in eclipse. The electromagnetic interference produced by solar panel occupies about 87% in the low frequency bend (<100 Hz)and 94% in the high frequency band (>100 Hz) of the total electromagnetic interference produced by satellite. These in flight observations of electromagnetic radiation of satellites will be very helpful to the designs of future satellites of space sciences or earthquake sciences.

  12. In-flight observations of electromagnetic interferences emitted by satellite

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    Using the data from STAFF/TC-1, this paper for the first time analyzes the electromagnetic interferences of Chinese scientific satellite. The electromagnetic interference of satellite exists mainly below 30 Hz, but can extend to 190 Hz with an obviously decreasing power spectral density. The electromagnetic interferences at frequencies below 190 Hz have good correlation with the solar aspect angle. The electromagnetic interferences at frequencies between 190 and 830 Hz have also correlation with solar as-pect angle. However, the electromagnetic interferences at frequencies above 830 Hz have no correlation with the solar aspect angle. The correlation coefficient between solar aspect angel and electromagnetic interferences is around 0.90. The larger the solar aspect angle, the stronger the satellite electromagnetic interference. When the solar aspect angle increases from 90.6° to 93.6°, the electromagnetic interferences at frequencies <10 Hz increase by 8 times and those at frequencies 190―830 Hz increase by 60%. This close association of electromagnetic interferences with the solar aspect angle indicates that the solar aspect angle is the main factor to determine the electromagnetic interferences. The electromagnetic interferences of satellite in sunlight are larger than those in eclipse. The electro-magnetic interference produced by solar panel occupies about 87% in the low frequency band (<100 Hz) and 94% in the high frequency band (>100 Hz) of the total electromagnetic interference produced by satellite. These in flight observations of electromagnetic radiation of satellites will be very helpful to the designs of future satellites of space sciences or earthquake sciences.

  13. Interference of spin states in photoemission from Sb/Ag(111) surface alloys

    Energy Technology Data Exchange (ETDEWEB)

    Meier, Fabian; Osterwalder, Juerg; Hugo Dil, J [Physik-Institut, Universitaet Zuerich, Winterthurerstrasse 190, CH-8057 Zuerich (Switzerland); Petrov, Vladimir [St Petersburg Polytechnical University, 29 Polytechnicheskaya Street, 195251 St Petersburg (Russian Federation); Mirhosseini, Hossein; Henk, Juergen [Max-Planck-Institut fuer Mikrostrukturphysik, D-06120 Halle (Saale) (Germany); Patthey, Luc, E-mail: jan-hugo.dil@psi.ch [Swiss Light Source, Paul Scherrer Institut, CH-5232 Villigen (Switzerland)

    2011-02-23

    Using a three-dimensional spin polarimeter we have gathered evidence for the interference of spin states in photoemission from the surface alloy Sb/Ag(111). This system features a small Rashba-type spin splitting of a size comparable to the momentum broadening of the quasiparticles, thus causing an intrinsic overlap between states with orthogonal spinors. Besides a small spin polarization caused by the spin splitting, we observe a large spin polarization component in the plane normal to the quantization axis of the Rashba effect. Strongly suggestive of coherent spin rotation, this effect is largely independent of the photon energy and photon polarization. (fast track communication)

  14. Viral suppressors of RNA interference impair RNA silencing induced by a Semliki Forest virus replicon in tick cells

    NARCIS (Netherlands)

    Garcia, S.; Billecocq, A.; Crance, J.M.; Prins, M.W.; Garin, D.; Bouloy, M.

    2006-01-01

    It was recently shown that infection of ISE6 tick cells by a recombinant Semliki Forest virus (SFV) expressing a heterologous gene induced small interfering RNAs (siRNAs) and silencing of the gene. To gain information on RNA interference (RNAi) in ticks, three known viral inhibitors that act in diff

  15. Estimating Digital Inter-Symbol Interference Channel Blindly Based on the One-Step Branch Transition Rules in Trellises

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    A novel discrete-time digital inter-symbol interference (ISI) channel blind estimation sub-optimal algorithm is proposed. This algorithm reduces the complexity of the optimal maximum likelihood sequence estimation(MLSE) considerably based on the one-step branch transition rules in trellises, and is suitable for the estimation of the channels with small lengths of ISI.

  16. Viral suppressors of RNA interference impair RNA silencing induced by a Semliki Forest virus replicon in tick cells

    NARCIS (Netherlands)

    Garcia, S.; Billecocq, A.; Crance, J.M.; Prins, M.W.; Garin, D.; Bouloy, M.

    2006-01-01

    It was recently shown that infection of ISE6 tick cells by a recombinant Semliki Forest virus (SFV) expressing a heterologous gene induced small interfering RNAs (siRNAs) and silencing of the gene. To gain information on RNA interference (RNAi) in ticks, three known viral inhibitors that act in diff

  17. Novel Method of Detecting Movement of the Interference Fringes Using One-Dimensional PSD

    Directory of Open Access Journals (Sweden)

    Qi Wang

    2015-06-01

    Full Text Available In this paper, a method of using a one-dimensional position-sensitive detector (PSD by replacing charge-coupled device (CCD to measure the movement of the interference fringes is presented first, and its feasibility is demonstrated through an experimental setup based on the principle of centroid detection. Firstly, the centroid position of the interference fringes in a fiber Mach-Zehnder (M-Z interferometer is solved in theory, showing it has a higher resolution and sensitivity. According to the physical characteristics and principles of PSD, a simulation of the interference fringe’s phase difference in fiber M-Z interferometers and PSD output is carried out. Comparing the simulation results with the relationship between phase differences and centroid positions in fiber M-Z interferometers, the conclusion that the output of interference fringes by PSD is still the centroid position is obtained. Based on massive measurements, the best resolution of the system is achieved with 5.15, 625 μm. Finally, the detection system is evaluated through setup error analysis and an ultra-narrow-band filter structure. The filter structure is configured with a one-dimensional photonic crystal containing positive and negative refraction material, which can eliminate background light in the PSD detection experiment. This detection system has a simple structure, good stability, high precision and easily performs remote measurements, which makes it potentially useful in material small deformation tests, refractivity measurements of optical media and optical wave front detection.

  18. Novel method of detecting movement of the interference fringes using one-dimensional PSD.

    Science.gov (United States)

    Wang, Qi; Xia, Ji; Liu, Xu; Zhao, Yong

    2015-06-02

    In this paper, a method of using a one-dimensional position-sensitive detector (PSD) by replacing charge-coupled device (CCD) to measure the movement of the interference fringes is presented first, and its feasibility is demonstrated through an experimental setup based on the principle of centroid detection. Firstly, the centroid position of the interference fringes in a fiber Mach-Zehnder (M-Z) interferometer is solved in theory, showing it has a higher resolution and sensitivity. According to the physical characteristics and principles of PSD, a simulation of the interference fringe's phase difference in fiber M-Z interferometers and PSD output is carried out. Comparing the simulation results with the relationship between phase differences and centroid positions in fiber M-Z interferometers, the conclusion that the output of interference fringes by PSD is still the centroid position is obtained. Based on massive measurements, the best resolution of the system is achieved with 5.15, 625 μm. Finally, the detection system is evaluated through setup error analysis and an ultra-narrow-band filter structure. The filter structure is configured with a one-dimensional photonic crystal containing positive and negative refraction material, which can eliminate background light in the PSD detection experiment. This detection system has a simple structure, good stability, high precision and easily performs remote measurements, which makes it potentially useful in material small deformation tests, refractivity measurements of optical media and optical wave front detection.

  19. INTERFERENCE COORDINATION METHOD BASED ON GRAPH THEORY IN TWO-TIER CELLULAR NETWORKS

    Institute of Scientific and Technical Information of China (English)

    Shi Jurong; Zhu Qi

    2013-01-01

    This paper studies an interference coordination method by means of spectrum allocation in Long-Term Evolution (LTE) multi-cell scenario that comprises of macrocells and femtocells.The purpose is to maximize the total throughput of femtocells while ensuring the Signal-to-Interference plus Noise Ratio (SINR) of the edge macro mobile stations (mMSs) and the edge femtocell Mobile Stations (fMSs).A new spectrum allocation algorithm based on graph theory is proposed to reduce the interference.Firstly,the ratio of Resource Blocks (RBs) that mMSs occupy is obtained by genetic algorithm.Then,after considering the impact of the macro Base Stations (mBSs) and small scale fading to the fMS on different RBs,multi-interference graphs are established and the spectrum is allocated dynamically.The simulation results show that the proposed algorithm can meet the Quality of Service (QoS) requirements of the mMSs.It can strike a balance between the edge fMSs' throughput and the whole fMSs' throughput.

  20. RNA interference in neuroscience: progress and challenges.

    Science.gov (United States)

    Miller, Victor M; Paulson, Henry L; Gonzalez-Alegre, Pedro

    2005-12-01

    1.RNA interference (RNAi) is a recently discovered biological pathway that mediates post-transcriptional gene silencing. The process of RNAi is orchestrated by an increasingly well-understood cellular machinery. 2. The common entry point for both natural and engineered RNAi are double stranded RNA molecules known as short interfering RNAs (siRNAs), that mediate the sequence-specific identification and degradation of the targeted messenger RNA (mRNA). The study and manipulation of these siRNAs has recently revolutionized biomedical research. 3. In this review, we first provide a brief overview of the process of RNAi, focusing on its potential role in brain function and involvement in neurological disease. We then describe the methods developed to manipulate RNAi in the laboratory and its applications to neuroscience. Finally, we focus on the potential therapeutic application of RNAi to neurological disease.

  1. Time-domain quantum interference in graphene

    Science.gov (United States)

    Fillion-Gourdeau, François; Gagnon, Denis; Lefebvre, Catherine; MacLean, Steve

    2016-09-01

    The electron momentum density obtained from the Schwinger-like mechanism is evaluated for a graphene sample immersed in a homogeneous time-dependent electric field. Based on the analogy between graphene low-energy electrons and quantum electrodynamics (QED), numerical techniques borrowed from strong field QED are employed and compared to approximate analytical approaches. It is demonstrated that for some range of experimentally accessible parameters, the pair production proceeds by sequences of adiabatic evolutions followed by nonadiabatic Landau-Zener transitions, reminiscent of the Kibble-Zurek mechanism describing topological defect density in second order phase transitions. For some field configurations, this yields interference patterns in momentum space which are explained in terms of the adiabatic-impulse model and the Landau-Zener-Stückelberg interferometry.

  2. Symbiont-mediated RNA interference in insects.

    Science.gov (United States)

    Whitten, Miranda M A; Facey, Paul D; Del Sol, Ricardo; Fernández-Martínez, Lorena T; Evans, Meirwyn C; Mitchell, Jacob J; Bodger, Owen G; Dyson, Paul J

    2016-02-24

    RNA interference (RNAi) methods for insects are often limited by problems with double-stranded (ds) RNA delivery, which restricts reverse genetics studies and the development of RNAi-based biocides. We therefore delegated to insect symbiotic bacteria the task of: (i) constitutive dsRNA synthesis and (ii) trauma-free delivery. RNaseIII-deficient, dsRNA-expressing bacterial strains were created from the symbionts of two very diverse pest species: a long-lived blood-sucking bug, Rhodnius prolixus, and a short-lived globally invasive polyphagous agricultural pest, western flower thrips (Frankliniella occidentalis). When ingested, the manipulated bacteria colonized the insects, successfully competed with the wild-type microflora, and sustainably mediated systemic knockdown phenotypes that were horizontally transmissible. This represents a significant advance in the ability to deliver RNAi, potentially to a large range of non-model insects.

  3. Scattering and interference in epitaxial graphene.

    Science.gov (United States)

    Rutter, G M; Crain, J N; Guisinger, N P; Li, T; First, P N; Stroscio, J A

    2007-07-13

    A single sheet of carbon, graphene, exhibits unexpected electronic properties that arise from quantum state symmetries, which restrict the scattering of its charge carriers. Understanding the role of defects in the transport properties of graphene is central to realizing future electronics based on carbon. Scanning tunneling spectroscopy was used to measure quasiparticle interference patterns in epitaxial graphene grown on SiC(0001). Energy-resolved maps of the local density of states reveal modulations on two different length scales, reflecting both intravalley and intervalley scattering. Although such scattering in graphene can be suppressed because of the symmetries of the Dirac quasiparticles, we show that, when its source is atomic-scale lattice defects, wave functions of different symmetries can mix.

  4. Grounding and shielding circuits and interference

    CERN Document Server

    Morrison, Ralph

    2016-01-01

    Applies basic field behavior in circuit design and demonstrates how it relates to grounding and shielding requirements and techniques in circuit design This book connects the fundamentals of electromagnetic theory to the problems of interference in all types of electronic design. The text covers power distribution in facilities, mixing of analog and digital circuitry, circuit board layout at high clock rates, and meeting radiation and susceptibility standards. The author examines the grounding and shielding requirements and techniques in circuit design and applies basic physics to circuit behavior. The sixth edition of this book has been updated with new material added throughout the chapters where appropriate. The presentation of the book has also been rearranged in order to reflect the current trends in the field.

  5. Quantum interference between transverse spatial waveguide modes

    Science.gov (United States)

    Mohanty, Aseema; Zhang, Mian; Dutt, Avik; Ramelow, Sven; Nussenzveig, Paulo; Lipson, Michal

    2017-01-01

    Integrated quantum optics has the potential to markedly reduce the footprint and resource requirements of quantum information processing systems, but its practical implementation demands broader utilization of the available degrees of freedom within the optical field. To date, integrated photonic quantum systems have primarily relied on path encoding. However, in the classical regime, the transverse spatial modes of a multi-mode waveguide have been easily manipulated using the waveguide geometry to densely encode information. Here, we demonstrate quantum interference between the transverse spatial modes within a single multi-mode waveguide using quantum circuit-building blocks. This work shows that spatial modes can be controlled to an unprecedented level and have the potential to enable practical and robust quantum information processing.

  6. Quantum interference between transverse spatial waveguide modes

    Science.gov (United States)

    Mohanty, Aseema; Zhang, Mian; Dutt, Avik; Ramelow, Sven; Nussenzveig, Paulo; Lipson, Michal

    2017-01-01

    Integrated quantum optics has the potential to markedly reduce the footprint and resource requirements of quantum information processing systems, but its practical implementation demands broader utilization of the available degrees of freedom within the optical field. To date, integrated photonic quantum systems have primarily relied on path encoding. However, in the classical regime, the transverse spatial modes of a multi-mode waveguide have been easily manipulated using the waveguide geometry to densely encode information. Here, we demonstrate quantum interference between the transverse spatial modes within a single multi-mode waveguide using quantum circuit-building blocks. This work shows that spatial modes can be controlled to an unprecedented level and have the potential to enable practical and robust quantum information processing. PMID:28106036

  7. Onomastic Interferences in the Language of Migration

    Directory of Open Access Journals (Sweden)

    Ioana Jieanu

    2015-12-01

    Full Text Available In case of bilingual speakers, proper names undergo different transformations, depending on the contextual character of a manifestation of meanings, “the relationship between the proper name and the denoted object being temporary, dependent on the verbal and situational context” (Tomescu 1998: 1. Within the scope of the current economic migration of Romanians to Spain and Italy, the names of Romanian people have undergone various modifications under the influence of Spanish and Italian onomastics. In the present work, the performance of two main tasks is described: an analysis of the interferences which emerge within communication, in case of the proper names of Romanian people who have emigrated to Spain and Italy; and classification of the proper names of new-born children within Romanian families that have settled in these countries.

  8. Interference theory of metamaterial perfect absorbers

    CERN Document Server

    Chen, Hou-Tong

    2011-01-01

    The impedance matching in metamaterial perfect absorbers has been believed to involve and rely on magnetic resonant response, with a direct evidence from the anti-parallel directions of surface currents in the metal structures. Here we present a different theoretical interpretation based on interferences, which shows that the two layers of metal structure in metamaterial absorbers are linked only by multiple reflections with negligible near-field interactions or magnetic resonances. This is further supported by the out-of-phase surface currents derived at the interfaces of resonator array and ground plane through multiple reflections and superpositions. The theory developed here explains all features observed in narrowband metamaterial absorbers and therefore provides a profound understanding of the underlying physics.

  9. Narrowband interference parameterization for sparse Bayesian recovery

    KAUST Repository

    Ali, Anum

    2015-09-11

    This paper addresses the problem of narrowband interference (NBI) in SC-FDMA systems by using tools from compressed sensing and stochastic geometry. The proposed NBI cancellation scheme exploits the frequency domain sparsity of the unknown signal and adopts a Bayesian sparse recovery procedure. This is done by keeping a few randomly chosen sub-carriers data free to sense the NBI signal at the receiver. As Bayesian recovery requires knowledge of some NBI parameters (i.e., mean, variance and sparsity rate), we use tools from stochastic geometry to obtain analytical expressions for the required parameters. Our simulation results validate the analysis and depict suitability of the proposed recovery method for NBI mitigation. © 2015 IEEE.

  10. Biomechanical performance of subpectoral biceps tenodesis: a comparison of interference screw fixation, cortical button fixation, and interference screw diameter.

    Science.gov (United States)

    Sethi, Paul M; Rajaram, Arun; Beitzel, Knut; Hackett, Thomas R; Chowaniec, David M; Mazzocca, Augustus D

    2013-04-01

    Subpectoral biceps tenodesis with interference screw fixation allows reproducible positioning of the tendon to help maintain the length-tension relationship. The aim of our study was to evaluate the role of cortical button fixation in isolation or as an augment to interference screw fixation and to determine if the diameter of the interference screw affected fixation strength. Thirty-two cadaveric shoulders were dissected and randomized to 1 of 4 groups: (1) 7-mm interference screw and cortical button, (2) cortical button alone, (3) 7-mm interference screw, or (4) 8-mm interference screw. Testing was performed on a materials testing system with a 100-N load cycled at 1 Hz for 5000 cycles, followed by an axial load to failure test. Cyclic displacement, ultimate load to failure, and site of failure were recorded for each specimen. The mean ultimate failure loads were 7-mm interference screw with cortical button augmentation, 237.8 ± 120.4 N; cortical button alone, 99.4 ± 16.9 N; 7-mm interference screw, 275.5 ± 56 N; 8-mm interference screw, 277.1 ± 42.1 N. All specimens failed through tendon failure at the screw-tendon-bone interface. The biomechanical performance of subpectoral biceps tenodesis with interference screw fixation was not improved with cortical button augmentation. In addition, cortical button fixation alone yielded a significantly lower ultimate load to failure compared with interference screws. Finally, the biomechanical performance of smaller-diameter interference screws with matching bone tunnels was not affected by interference screw diameter. Copyright © 2013 Journal of Shoulder and Elbow Surgery Board of Trustees. Published by Mosby, Inc. All rights reserved.

  11. Cooperative Precoding with Limited Feedback for MIMO Interference Channels

    CERN Document Server

    Huang, Kaibin

    2010-01-01

    Multi-antenna precoding effectively mitigates the interference in wireless networks. However, the resultant performance gains can be significantly compromised in practice if the precoder design fails to account for the inaccuracy in the channel state information (CSI) feedback. This paper addresses this issue by considering finite-rate CSI feedback from receivers to their interfering transmitters in the two-user multiple-input-multiple-output (MIMO) interference channel, called \\emph{cooperative feedback}, and proposing a systematic precoder design. Specifically, each precoder is decomposed into inner and outer precoders for nulling interference and improving the data-link array gain, respectively. The inner precoders are further designed to suppress the residual interference resulting from the finite-rate cooperative feedback. To regulate such interference, additional scalar cooperative feedback signals are designed to control transmission power using different criteria including fixed interference margins, ...

  12. Quantum Interference in Time-Delayed Nonsequential Double Ionization

    CERN Document Server

    Maxwell, A S

    2015-01-01

    We perform a systematic analysis of quantum interference in nonsequential double ionization focusing on the recollision-excitation with subsequent ionization (RESI) mechanism, employing the strong-field approximation (SFA). We find that interference has a major influence on the shape, localization and symmetry of the correlated electron momentum distributions. In particular, the fourfold symmetry with regard to the parallel momentum components observed in previous SFA studies is broken. Two types of interference are observed and thoroughly analyzed, namely that caused by electron indistinguishability and intra-cycle events, and that stemming from different excitation channels. We find that interference is most prominent around the diagonal and anti-diagonal in the parallel-momentum plane and provide fully analytical expressions for most interference patterns encountered. We also show that this interference can be controlled by an appropriate choice of phase and excited-state geometry. This leads a to myriad o...

  13. Cognitive Aware Interference Mitigation Scheme for LTE Femtocells

    KAUST Repository

    Alqerm, Ismail

    2015-04-21

    Femto-cells deployment in today’s cellular networks came into practice to fulfill the increasing demand for data services. However, interference to other femto and macro-cells users remains an unresolved challenge. In this paper, we propose an interference mitigation scheme to control the cross-tier interference caused by femto-cells to the macro users and the co-tier interference among femtocells. Cognitive radio spectrum sensing capability is utilized to determine the non-occupied channels or the ones that cause minimal interference to the macro users. An awareness based channel allocation scheme is developed with the assistance of the graph-coloring algorithm to assign channels to the femto-cells base stations with power optimization, minimal interference, maximum throughput, and maximum spectrum efficiency. In addition, the scheme exploits negotiation capability to match traffic load and QoS with the channel capacity, and to maintain efficient utilization of the available channels.

  14. Increased Stroop interference with better second-language reading skill.

    Science.gov (United States)

    Braet, Wouter; Noppe, Nele; Wagemans, Johan; Op de Beeck, Hans

    2011-03-01

    Skilled readers demonstrate remarkable efficiency in processing written words, unlike beginning readers for whom reading occurs more serially and places higher demands on visual attention. In the present study, we used the Stroop paradigm to investigate the relationship between reading skill and automaticity, in individuals learning a second language with a different orthographic system. Prior studies using this paradigm have presented a mixed picture, finding a positive, a negative, or no relationship between the size of Stroop interference and reading skills. Our results show that Stroop interference in the second language was positively related to reading skill (when controlled for interference in the first language). Furthermore, interference was positively related to objective but not subjective indices of the amount of exposure to the second language. We suggest that the lack of consistency in the results of earlier studies may be due, at least in part, to these studies looking at Stroop interference in isolation, rather than comparing interference between languages.

  15. Interference Control Modulations Over Conscious Perception

    Directory of Open Access Journals (Sweden)

    Itsaso Colás

    2017-05-01

    Full Text Available The relation between attention and consciousness has been a controversial topic over the last decade. Although there seems to be an agreement on their distinction at the functional level, no consensus has been reached about attentional processes being or not necessary for conscious perception. Previous studies have explored the relation of alerting and orienting systems of attention and conscious perception, but the impact of the anterior executive attention system on conscious access remains unexplored. In the present study, we investigated the behavioral interaction between executive attention and conscious perception, testing control mechanisms both at stimulus-level representation and after error commission. We presented a classical Stroop task, manipulating the proportion of congruent and incongruent trials, and analyzed the effect of reactive and proactive control on the conscious perception of near-threshold stimuli. Reactive control elicited under high proportion congruent conditions influenced participants’ decision criterion, whereas proactive control elicited under low proportion congruent conditions was ineffective in modulating conscious perception. In addition, error commission affected both perceptual sensitivity to detect near-threshold information and response criterion. These results suggest that reactivation of task goals through reactive control strategies in conflict situations impacts decision stages of conscious processing, whereas interference control elicited by error commission impacts both perceptual sensitivity and decision stages of conscious processing. We discuss the implications of our results for the gateway hypothesis about attention and consciousness, as they showed that interference control (both at stimulus-level representation and after error commission can modulate the conscious access of near-threshold stimuli.

  16. Quasiparticle interference in unconventional 2D systems

    Science.gov (United States)

    Chen, Lan; Cheng, Peng; Wu, Kehui

    2017-03-01

    At present, research of 2D systems mainly focuses on two kinds of materials: graphene-like materials and transition-metal dichalcogenides (TMDs). Both of them host unconventional 2D electronic properties: pseudospin and the associated chirality of electrons in graphene-like materials, and spin-valley-coupled electronic structures in the TMDs. These exotic electronic properties have attracted tremendous interest for possible applications in nanodevices in the future. Investigation on the quasiparticle interference (QPI) in 2D systems is an effective way to uncover these properties. In this review, we will begin with a brief introduction to 2D systems, including their atomic structures and electronic bands. Then, we will discuss the formation of Friedel oscillation due to QPI in constant energy contours of electron bands, and show the basic concept of Fourier-transform scanning tunneling microscopy/spectroscopy (FT-STM/STS), which can resolve Friedel oscillation patterns in real space and consequently obtain the QPI patterns in reciprocal space. In the next two parts, we will summarize some pivotal results in the investigation of QPI in graphene and silicene, in which systems the low-energy quasiparticles are described by the massless Dirac equation. The FT-STM experiments show there are two different interference channels (intervalley and intravalley scattering) and backscattering suppression, which associate with the Dirac cones and the chirality of quasiparticles. The monolayer and bilayer graphene on different substrates (SiC and metal surfaces), and the monolayer and multilayer silicene on a Ag(1 1 1) surface will be addressed. The fifth part will introduce the FT-STM research on QPI in TMDs (monolayer and bilayer of WSe2), which allow us to infer the spin texture of both conduction and valence bands, and present spin-valley coupling by tracking allowed and forbidden scattering channels.

  17. Interference Assembly and Fretting Wear Analysis of Hollow Shaft

    OpenAIRE

    Chuanjun Han; Jie Zhang

    2014-01-01

    Fretting damage phenomenon often appears in the interference fit assembly. The finite element model of hollow shaft and shaft sleeve was established, and the equivalent stress and contact stress were computed after interference assembly. The assembly body of hollow shaft and shaft sleeve was in whirling bending load, and the contact status (sticking, sliding, and opening) and the distribution of stress along one typical contact line were computed under different loads, interferences, hollow d...

  18. Interference cancellation technique under imperfect synchronization in cellular systems

    Institute of Scientific and Technical Information of China (English)

    WANG; Xin; WU; Zhuo

    2009-01-01

    In this paper, an asynchronous cooperative cellular system applied with space-time block coding(STBC)is investigated. A signal detector is proposed based on parallel interference cancellation(PIC), to cancel the inter-symbol interference(ISI)caused by the imperfect synchronization. Simulation results show that the proposed PIC detector can effectively suppress the ISI, but there is still a comparatively high error floor, due to the co-channel interference(CCI)of the cellular system.

  19. Cross Layer Interference Management in Wireless Biomedical Networks

    OpenAIRE

    Spanakis, Emmanouil G.; Vangelis Sakkalis; Kostas Marias; Apostolos Traganitis

    2014-01-01

    Interference, in wireless networks, is a central phenomenon when multiple uncoordinated links share a common communication medium. The study of the interference channel was initiated by Shannon in 1961 and since then this problem has been thoroughly elaborated at the Information theoretic level but its characterization still remains an open issue. When multiple uncoordinated links share a common medium the effect of interference is a crucial limiting factor for network performance. In this wo...

  20. Dynamic Resource Coordination and Interference Management for Femtocell Networks

    CERN Document Server

    Liang, Yan; Yang, Chunliang

    2010-01-01

    Femtocell is emerging as a key technology to secure the coverage and capacity in indoor environments. However the deployment of a new femtocell layer may originate undesired interference to the whole system. This paper investigates spectrum resource coordination and interference management for the femtocell networks. A resource coordination scheme based on broadcasting resource coordination request messages by the femto mobile is proposed to reduce the system interference.

  1. Two-photon interference with non-identical photons

    Science.gov (United States)

    Liu, Jianbin; Zhou, Yu; Zheng, Huaibin; Chen, Hui; Li, Fu-li; Xu, Zhuo

    2015-11-01

    Two-photon interference with non-identical photons is studied based on the superposition principle in Feynman's path integral theory. The second-order temporal interference pattern is observed by superposing laser and pseudothermal light beams with different spectra. The reason why there is two-photon interference for photons of different spectra is that non-identical photons can be indistinguishable for the detection system when Heisenberg's uncertainty principle is taken into account. These studies are helpful to understand the second-order interference of light in the language of photons.

  2. Cognitive interference modeling with applications in power and admission control

    KAUST Repository

    Mahmood, Nurul Huda

    2012-10-01

    One of the key design challenges in a cognitive radio network is controlling the interference generated at coexisting primary receivers. In order to design efficient cognitive radio systems and to minimize their unwanted consequences, it is therefore necessary to effectively control the secondary interference at the primary receivers. In this paper, a generalized framework for the interference analysis of a cognitive radio network where the different secondary transmitters may transmit with different powers and transmission probabilities, is presented and various applications of this interference model are demonstrated. The findings of the analytical performance analyses are confirmed through selected computer-based Monte-Carlo simulations. © 2012 IEEE.

  3. On the Beamforming Design for Efficient Interference Alignment

    CERN Document Server

    Choi, Sang Won; Chung, Sae-Young

    2009-01-01

    An efficient interference alignment (IA) scheme is developed for $K$-user single-input single-output frequency selective fading interference channels. The main idea is to steer the transmit beamforming matrices such that at each receiver the subspace dimensions occupied by interference-free desired streams are asymptotically the same as those occupied by all interferences. Our proposed scheme achieves a higher multiplexing gain at any given number of channel realizations in comparison with the original IA scheme, which is known to achieve the optimal multiplexing gain asymptotically.

  4. Classical and quantum interference in multiband optical Bloch oscillations

    CERN Document Server

    Longhi, S

    2010-01-01

    Classical and quantum interference of light propagating in arrays of coupled waveguides and undergoing multiband optical Bloch oscillations (BOs) with negligible Zener tunneling is theoretically investigated. In particular, it is shown that Mach-Zehnder-like interference effects spontaneously arise in multiband BOs owing to beam splitting and subsequent beam recombination occurring in one BO cycle. As a noteworthy example of quantum interference, we discuss the doubling of interference fringes in photon counting rates for a correlated photon pair undergoing two-band BOs, a phenomenon analogous to the manifestation of the de Broglie wavelength of an entangled biphoton state observed in quantum Mach-Zehnder interferometry.

  5. Two-photon Interference with Non-identical Photons

    CERN Document Server

    Liu, Jianbin; Zheng, Huaibin; Chen, Hui; Li, Fu-Li; Xu, Zhuo

    2014-01-01

    The indistinguishability of non-identical photons is dependent on detection system in quantum physics. If two photons with different wavelengths are indistinguishable for a detection system, there can be two-photon interference when these two photons are incident to two input ports of a Hong-Ou-Mandel interferometer, respectively. The reason why two-photon interference phenomena are different for classical and nonclassical light is not due to interference, but due to the properties of light and detection system. These conclusions are helpful to understand the physics and applications of two-photon interference.

  6. Interference susceptibility measurements for an MSK satellite communication link

    Science.gov (United States)

    Kerczewski, Robert J.; Fujikawa, Gene

    1992-01-01

    The results are presented of measurements of the degradation of an MSK satellite link due to modulated and CW (unmodulated) interference. These measurements were made using a hardware based satellite communication link simulator at NASA-Lewis. The results indicate the amount of bit error rate degradation caused by CW interference as a function of frequency and power level, and the degradation caused by adjacent channel and cochannel modulated interference as a function of interference power level. Results were obtained for both the uplink case (including satellite nonlinearity) and the downlink case (linear channel).

  7. 47 CFR 101.105 - Interference protection criteria.

    Science.gov (United States)

    2010-10-01

    ... radio that is modulated by a standard, television (visual) signal, the allowable interference level per... region consisting of the following states: Wyoming, Colorado, New Mexico, Utah, Arizona, Nevada,...

  8. 47 CFR 101.509 - Interference protection criteria.

    Science.gov (United States)

    2010-10-01

    ..., and radiation pattern of the transmitting and receiving antennas. Licensees are expected to cooperate fully in attempting to resolve problems of potential interference before bringing the matter to...

  9. The right posterior paravermis and the control of language interference.

    Science.gov (United States)

    Filippi, Roberto; Richardson, Fiona M; Dick, Frederic; Leech, Robert; Green, David W; Thomas, Michael S C; Price, Cathy J

    2011-07-20

    Auditory and written language in humans' comprehension necessitates attention to the message of interest and suppression of interference from distracting sources. Investigating the brain areas associated with the control of interference is challenging because it is inevitable that activation of the brain regions that control interference co-occurs with activation related to interference per se. To isolate the mechanisms that control verbal interference, we used a combination of structural and functional imaging techniques in Italian and German participants who spoke English as a second language. First, we searched structural MRI images of Italian participants for brain regions in which brain structure correlated with the ability to suppress interference from the unattended dominant language (Italian) while processing heard sentences in their weaker language (English). This revealed an area in the posterior paravermis of the right cerebellum in which gray matter density was higher in individuals who were better at controlling verbal interference. Second, we found functional activation in the same region when our German participants made semantic decisions on written English words in the presence of interference from unrelated words in their dominant language (German). This combination of structural and functional imaging therefore highlights the contribution of the right posterior paravermis to the control of verbal interference. We suggest that the importance of this region for language processing has previously been missed because most fMRI studies limit the field of view to increase sensitivity, with the lower part of the cerebellum being the region most likely to be excluded.

  10. Neural basis of semantic and syntactic interference in sentence comprehension.

    Science.gov (United States)

    Glaser, Yi G; Martin, Randi C; Van Dyke, Julie A; Hamilton, A Cris; Tan, Yingying

    2013-09-01

    According to the cue-based parsing approach (Lewis, Vasishth, & Van Dyke, 2006), sentence comprehension difficulty derives from interference from material that partially matches syntactic and semantic retrieval cues. In a 2 (low vs. high semantic interference)×2 (low vs. high syntactic interference) fMRI study, greater activation was observed in left BA44/45 for high versus low syntactic interference conditions following sentences and in left BA45/47 for high versus low semantic interference conditions following comprehension questions. A conjunction analysis showed BA45 associated with both types of interference, while BA47 was associated with only semantic interference. Greater activation was also observed in the left STG in the high interference conditions. Importantly, the results for the LIFG could not be attributed to greater working memory capacity demands for high interference conditions. The results favor a fractionation of the LIFG wherein BA45 is associated with post-retrieval selection and BA47 with controlled retrieval of semantic information.

  11. An Anti-Interference Coding in UWB-OFDM Communications

    Institute of Scientific and Technical Information of China (English)

    ZHANG Shi-bing; CAO Shi-ke; ZHANG Li-jun

    2005-01-01

    An anti-interference orthogonal coding is introduced based on Hadamard code and Orthogonal Frequency-Division Multiplexing (OFDM), in which all sub-channels of Ultra-WideBand (UWB) system are divided into M sub-bands and the power of the every transmitted symbol spreads over each of the sub-bands rather than one sub-band. The complete mathematical analytical relation between encoding and decoding is present and the robustness of the system to interference is examined. When some sub-channels are affected by interference or jamming, the system could regenerate the symbol from others. Simulation results show that the Anti-Interference UWB-OFDM (AI-OFDM) system has evident advantages over conventional UWB-OFDM systems as well as the Interference Suppressing UWB-OFDM (IS-OFDM) in Bit Error Rate (BER) thanks to its robustness to interference. In the case of bad interference, the AI-OFDM system could work up to snuff without any anti-interference step, but the conventional UWB-OFDM system couldn't. Compared with the IS-OFDM system, the AI-OFDM system improves the performance about 5 dB in Signal-to-Interference Ratio (SIR) and the order of 1~2 in BER.

  12. Adaptive cancellation of Es layer interference using auxiliary horizontal antennas

    Institute of Scientific and Technical Information of China (English)

    Zhao Long; Zhang Ning

    2006-01-01

    Based on a dual-polarization high-frequency wave radar system, an adaptive system using horizontal antennas for the suppression of the Es layer interference (ELI) is described. The data received from the horizontal antennas were correlated with the data received from the Vertically Polarized Antennas (VPAs) to estimate and cancel the interference adaptively in the VPAs. Suppressing the interference after each coherent integration time interval, about 25 dB signal-to-interference ratio is expected with the experimentally derived data.

  13. The phenomenon of RNA interference in oncology: advances, problems and perspectives

    Directory of Open Access Journals (Sweden)

    O. E. Andreeva

    2016-01-01

    Full Text Available Review describes the phenomenon of RNA interference – the recently discovered biological mechanism of the negative regulation of gene expression. The mechanism is based on the block of the translation and/or degradation of messenger RNA under short non-coding RNA, among them: microRNA and small interfering RNA. The paper reviews the molecular processes of the formation of small RNA, the mechanism of their action and the feasibility of small RNA implementation in the anti-tumor therapy. Specially, we analyze the approaches to in vivo delivery of small RNA, in particular – the liposome and exosome constructs, and perspectives of the involvement of such constructs in the cancer treatment.

  14. A novel deliver way of gene silencing by renal artery infusion of naked small interference RNA in a rat renal transplant model%经肾动脉灌注细胞间粘附分子—1小片段干扰RNA减轻移植肾缺血再灌注损伤

    Institute of Scientific and Technical Information of China (English)

    罗光恒; 卢一平; 杨立; 宋珺; 马学; 张立元; 李幼平

    2009-01-01

    Objective To investigate the potential preventive role of small interfering RNA targeting ICAM-1 (ICAM-1siRNA) infusion through renal artery in renal transplant cold ischemia injury model. Methods Fisher rats underwent renal isografting. Following removal, the left kidney was preserved in 0 to 4℃ heparin normal saline (NS) solution for 1 h to reinforce the cold ischemia injury. Before transplant, either ICAM-1siRNA (0.1 mg/kg), or (NS) or control siRNA was infused through the renal artery with the renal vein clamped ex vivo. The left kidney was then implanted and the right kidney was removed. At 6, 12, 24, 48 and 72 h post-operation, serum Cr was measured, and the severity of tubular necrosis and inflamed cells infiltration was assessed by histological grading scale respectively. The expression of ICAM-1 mRNA and protein in isograft was detected by real-time RT-PCR and Western blot, respectively. Results Compared with the NS and control siRNA groups, the values of serum Cr in siRNA group were lower at every time point, and the difference after 12 h was statistically significant (P = 0.01~0.001), but there was no significant difference between NS and control siRNA groups (P>0.05). The tubular necrosis and inflamed cells infiltration were less severe in siRNA group than those in NS and control siRNA groups, with the difference being significant especially in 12, 24 and 48 h. After 12 h, the expression levels of ICAM-1 mRNA and protein in the kidney of siRNA group were significantly down-regulated as compared with NS and control siRNA groups, and the difference reached its peak at 24 h. There was no significant difference among 3 groups at 72 h (P>0.05). Conclusion ICAM-1siRNA can significantly prevent and attenuate the renal damage secondary to ischemia by down-regulating the expression of ICAM-1 protein and mRNA.%目的 探讨经肾动脉灌注细胞间粘附分子-1小片段干扰RNA(ICAM-1 siRNA)对移植肾缺血再灌注损伤(IRI)的影响.方法

  15. On the Degrees of Freedom Achievable Through Interference Alignment in a MIMO Interference Channel

    CERN Document Server

    Razaviyayn, Meisam; Luo, Zhi-Quan

    2011-01-01

    Consider a K-user flat fading MIMO interference channel where the k-th transmitter (or receiver) is equipped with M_k (respectively N_k) antennas. If a large number of statistically independent channel extensions are allowed either across time or frequency, the recent work [1] suggests that the total achievable degrees of freedom (DoF) can be maximized via interference alignment, resulting in a total DoF that grows linearly with K even if M_k and N_k are bounded. In this work we consider the case where no channel extension is allowed, and establish a general condition that must be satisfied by any degrees of freedom tuple (d_1, d2, ..., d_K) achievable through linear interference alignment. For a symmetric system with M_k = M, N_k = N, d_k = d for all k, this condition implies that the total achievable DoF cannot grow linearly with K, and is in fact no more than K(M + N)=(K + 1). We also show that this bound is tight when the number of antennas at each transceiver is divisible by the number of data streams.

  16. Interference Alignment and Neutralization in a Cognitive 3-User MAC-Interference Channel: Degrees of Freedom

    CERN Document Server

    Chaaban, Anas

    2011-01-01

    A network consisting of a point-to-point (P2P) link and a multiple access channel (MAC) sharing the same medium is considered. The resulting interference network, with three transmitters and two receivers is studied from degrees of freedom (DoF) perspective, with and without cognition. Several cognition variants are examined. Namely, the setup is studied with (1) no cognitive transmitters, (2) a cognitive P2P transmitter, (3) one cognitive MAC transmitter, and (4) with two cognitive MAC transmitters. It is shown that having a cognitive P2P transmitter does not bring any DoF gain to the network. This is obtained by showing that the DoF of the two former cases (1) and (2) is 1. However, it is shown that a cognitive MAC transmitter is more beneficial since the latter two cases (3) and (4) have 3/2 DoF. The achievability of 3/2 DoF is guaranteed by using a combination of interference neutralization and interference alignment.

  17. Crystallized Rates Region of the Interference Channel via Correlated Equilibrium with Interference as Noise

    CERN Document Server

    Charafeddine, Mohamad; Paulraj, Arogyaswami; Cioffi, John

    2010-01-01

    Treating the interference as noise in the n-user interference channel, the paper describes a novel approach to the rates region, composed by the time-sharing convex hull of 2^n-1 corner points achieved through On/Off binary power control. The resulting rates region is denoted crystallized rates region. By treating the interference as noise, the n-user rates region frontiers has been found in the literature to be the convex hull of n hyper-surfaces. The rates region bounded by these hyper-surfaces is not necessarily convex, and thereby a convex hull operation is imposed through the strategy of time-sharing. This paper simplifies this rates region in the n-dimensional space by having only an On/Off binary power control. This consequently leads to 2^n-1 corner points situated within the rates region. A time-sharing convex hull is imposed onto those corner points, forming the crystallized rates region. The paper focuses on game theoretic concepts to achieve that crystallized convex hull via correlated equilibrium...

  18. Inducing RNA interference in the arbovirus vector, Culicoides sonorensis.

    Science.gov (United States)

    Mills, M K; Nayduch, D; Michel, K

    2015-02-01

    Biting midges in the genus Culicoides are important vectors of arboviral diseases, including epizootic haemorrhagic disease, bluetongue and most likely Schmallenberg, which cause significant economic burdens worldwide. Research on these vectors has been hindered by the lack of a sequenced genome, the difficulty of consistent culturing of certain species and the absence of molecular techniques such as RNA interference (RNAi). Here, we report the establishment of RNAi as a research tool for the adult midge, Culicoides sonorensis. Based on previous research and transcriptome analysis, which revealed putative small interfering RNA pathway member orthologues, we hypothesized that adult C. sonorensis midges have the molecular machinery needed to perform RNA silencing. Injection of control double-stranded RNA targeting green fluorescent protein (dsGFP), into the haemocoel of 2-3-day-old adult female midges resulted in survival curves that support virus transmission. dsRNA injection targeting the newly identified C. sonorensis inhibitor of apoptosis protein 1 (CsIAP1) orthologue resulted in a 40% decrease of transcript levels and 73% shorter median survivals as compared with dsGFP-injected controls. These results reveal the conserved function of IAP1. Importantly, they also demonstrate the feasibility of RNAi by dsRNA injection in adult midges, which will greatly facilitate studies of the underlying mechanisms of vector competence in C. sonorensis.

  19. RNA interference-mediated inhibition of Hepatitis B Virus replication

    Institute of Scientific and Technical Information of China (English)

    TANG Ni; ZHANG Bingqiang; YAN Ge; PU Dan; GAO Xiaolin; Tong-Chuan He; HUANG Ailong

    2004-01-01

    Persistent and recurrent infection of hepatitis B virus (HBV) represents one of the most common and severe viral infections of humans, and has caused a formidable health problem in the affected countries. Currently used antiviral drugs have a very limited success on controlling HBV replication and infection. RNA interference (RNAi), a process by which double-stranded RNA (dsRNA) directs sequence-specific degradation of target mRNA in mammalian and plant cells, has recently been used to knockdown gene expression in various species. In this study, we sought to determine whether RNAi-mediated silencing of HBV viral gene expression could lead to the effective inhibition of HBV replication. We first developed RNAi vectors that expressed small interfering RNA (siRNA) and targeted the HBV core or surface gene sequence. Our results demonstrated that these specific siRNAs efficiently reduced the levels of corresponding viral RNAs and proteins, and thus suppressed viral replication. Treatment with siRNA gave the greatest reduction in the levels of HBsAg (92%) and in HBeAg (85%) respectively in the cultured cell medium. Our findings further demonstrated that the RNAi-mediated antiviral effect was sequence-specific and dose-dependent. Therefore, our findings strongly suggest that RNAi-mediated silencing of HBV viral genes could effectively inhibit the replication of HBV, hence RNAi-based strategy should be further explored as a more efficacious antiviral therapy of HBV infection.

  20. Silencing structural and nonstructural genes in baculovirus by RNA interference.

    Science.gov (United States)

    Flores-Jasso, C Fabian; Valdes, Victor Julian; Sampieri, Alicia; Valadez-Graham, Viviana; Recillas-Targa, Felix; Vaca, Luis

    2004-06-01

    We review several aspects of RNAi and gene silencing with baculovirus. We show that the potency of RNAi in Spodoptera frugiperda (Sf21) insect cells correlates well with the efficiency of transfection of the siRNA. Using a fluorescein-labeled siRNA we found that the siRNA localized in areas surrounding the endoplasmic reticulum (ER). Both long (700 nucleotides long) and small ( approximately 25 nucleotides long) interfering RNAs were equally effective in initiating RNA interference (RNAi), and the duration of the interfering effect was indistinguishable. Even though RNAi in Sf21 cells is very effective, in vitro experiments show that these cells fragment the long dsRNA into siRNA poorly, when compared to HEK cells. Finally, we show that in vivo inhibition of baculovirus infection with dsRNA homologous to genes that are essential for baculovirus infectivity depends strongly on the amount of dsRNA used in the assays. Five hundred nanogram of dsRNA directly injected into the haemolymph of insects prevent animal death to over 95%. In control experiments, over 96% of insects not injected with dsRNA or injected with an irrelevant dsRNA died within a week. These results demonstrate the efficiency of dsRNA for in vivo prevention of a viral infection by virus that is very cytotoxic and lytic in animals.

  1. Discovery of novel targets with high throughput RNA interference screening.

    Science.gov (United States)

    Kassner, Paul D

    2008-03-01

    High throughput technologies have the potential to affect all aspects of drug discovery. Considerable attention is paid to high throughput screening (HTS) for small molecule lead compounds. The identification of the targets that enter those HTS campaigns had been driven by basic research until the advent of genomics level data acquisition such as sequencing and gene expression microarrays. Large-scale profiling approaches (e.g., microarrays, protein analysis by mass spectrometry, and metabolite profiling) can yield vast quantities of data and important information. However, these approaches usually require painstaking in silico analysis and low-throughput basic wet-lab research to identify the function of a gene and validate the gene product as a potential therapeutic drug target. Functional genomic screening offers the promise of direct identification of genes involved in phenotypes of interest. In this review, RNA interference (RNAi) mediated loss-of-function screens will be discussed and as well as their utility in target identification. Some of the genes identified in these screens should produce similar phenotypes if their gene products are antagonized with drugs. With a carefully chosen phenotype, an understanding of the biology of RNAi and appreciation of the limitations of RNAi screening, there is great potential for the discovery of new drug targets.

  2. Detection and severity classification of extracardiac interference in {sup 82}Rb PET myocardial perfusion imaging

    Energy Technology Data Exchange (ETDEWEB)

    Orton, Elizabeth J., E-mail: eorton@physics.carleton.ca; Kemp, Robert A. de; Glenn Wells, R. [Division of Cardiology, Department of Medicine, University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, Ontario K1Y 4W7 (Canada); Department of Physics, Carleton University, 1125 Colonel By Drive, Ottawa, Ontario K1S 5B6 (Canada); Al Harbi, Ibraheem [Division of Cardiology, Department of Medicine, University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, Ontario K1Y 4W7 (Canada); Department of Medicine (Cardiology), King Fahad Hospital, Medina 42351 (Saudi Arabia); Klein, Ran [Division of Cardiology, Department of Medicine, University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, Ontario K1Y 4W7 (Canada); Department of Biomedical Engineering, Carleton University, 1125 Colonel By Drive, Ottawa, Ontario K1S 5B6 (Canada); Beanlands, Rob S. B. [Division of Cardiology, Department of Medicine, University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, Ontario K1Y 4W7 (Canada)

    2014-10-15

    Purpose: Myocardial perfusion imaging (MPI) is used for diagnosis and prognosis of coronary artery disease. When MPI studies are performed with positron emission tomography (PET) and the radioactive tracer rubidium-82 chloride ({sup 82}Rb), a small but non-negligible fraction of studies (∼10%) suffer from extracardiac interference: high levels of tracer uptake in structures adjacent to the heart which mask the true cardiac tracer uptake. At present, there are no clinically available options for automated detection or correction of this problem. This work presents an algorithm that detects and classifies the severity of extracardiac interference in {sup 82}Rb PET MPI images and reports the accuracy and failure rate of the method. Methods: A set of 200 {sup 82}Rb PET MPI images were reviewed by a trained nuclear cardiologist and interference severity reported on a four-class scale, from absent to severe. An automated algorithm was developed that compares uptake at the external border of the myocardium to three thresholds, separating the four interference severity classes. A minimum area of interference was required, and the search region was limited to that facing the stomach wall and spleen. Maximizing concordance (Cohen’s Kappa) and minimizing failure rate for the set of 200 clinician-read images were used to find the optimal population-based constants defining search limit and minimum area parameters and the thresholds for the algorithm. Tenfold stratified cross-validation was used to find optimal thresholds and report accuracy measures (sensitivity, specificity, and Kappa). Results: The algorithm was capable of detecting interference with a mean [95% confidence interval] sensitivity/specificity/Kappa of 0.97 [0.94, 1.00]/0.82 [0.66, 0.98]/0.79 [0.65, 0.92], and a failure rate of 1.0% ± 0.2%. The four-class overall Kappa was 0.72 [0.64, 0.81]. Separation of mild versus moderate-or-greater interference was performed with good accuracy (sensitivity

  3. RNA interference targets arbovirus replication in Culicoides cells.

    Science.gov (United States)

    Schnettler, Esther; Ratinier, Maxime; Watson, Mick; Shaw, Andrew E; McFarlane, Melanie; Varela, Mariana; Elliott, Richard M; Palmarini, Massimo; Kohl, Alain

    2013-03-01

    Arboviruses are transmitted to vertebrate hosts by biting arthropod vectors such as mosquitoes, ticks, and midges. These viruses replicate in both arthropods and vertebrates and are thus exposed to different antiviral responses in these organisms. RNA interference (RNAi) is a sequence-specific RNA degradation mechanism that has been shown to play a major role in the antiviral response against arboviruses in mosquitoes. Culicoides midges are important vectors of arboviruses, known to transmit pathogens of humans and livestock such as bluetongue virus (BTV) (Reoviridae), Oropouche virus (Bunyaviridae), and likely the recently discovered Schmallenberg virus (Bunyaviridae). In this study, we investigated whether Culicoides cells possess an antiviral RNAi response and whether this is effective against arboviruses, including those with double-stranded RNA (dsRNA) genomes, such as BTV. Using reporter gene-based assays, we established the presence of a functional RNAi response in Culicoides sonorensis-derived KC cells which is effective in inhibiting BTV infection. Sequencing of small RNAs from KC and Aedes aegypti-derived Aag2 cells infected with BTV or the unrelated Schmallenberg virus resulted in the production of virus-derived small interfering RNAs (viRNAs) of 21 nucleotides, similar to the viRNAs produced during arbovirus infections of mosquitoes. In addition, viRNA profiles strongly suggest that the BTV dsRNA genome is accessible to a Dicer-type nuclease. Thus, we show for the first time that midge cells target arbovirus replication by mounting an antiviral RNAi response mainly resembling that of other insect vectors of arboviruses.

  4. RNA interference-based therapeutics: molecular platforms for infectious diseases.

    Science.gov (United States)

    Dyawanapelly, Sathish; Ghodke, Sharwari Bhagwat; Vishwanathan, Ramya; Dandekar, Prajakta; Jain, Ratnesh

    2014-09-01

    The potential uses and therapeutic benefits of RNA interference (RNAi) are enormous. Recent insights into RNAi technologies have highlighted their role in analyzing the functions and regulation of gene expression in eukaryotes and further utilizing this information for identification and amelioration of many diseases. These studies have also established the role of RNAi mediated post-transcriptional gene silencing (PTGS) mechanism in mammals by several endogenous, gene regulation systems including small interfering RNAs (siRNA), micro RNA (miRNA) and small hairpin RNAs (shRNA). Moreover, these RNAi-based therapeutics have demonstrated the capability to silence therapeutically relevant genes in various in vivo models of cancer, infections autoimmune diseases and other genetic disorders. Over the past few decades, infectious diseases have been one of the leading causes of death around the world. Ubiquitously, intracellular obligate or facultative microorganisms cause serious or fatal infections and associated diseases in humans. Currently available literature suggests that infections caused by intracellular pathogens present an intriguing area, wherein RNAi technology may be effectively employed to neutralize the harmful effects of various intracellular pathogens. In this manuscript, we have emphasized on the challenges and opportunities involved in the therapy of such intracellular infections, especially employing RNAi-based interventions. We have focused our discussion on the current state-of-the-art RNAi-based therapies, which have been explored for various intracellular infections mediated by bacteria, fungi, viruses and protozoa. Nanocarrier mediated delivery of siRNA and shRNA molecules have also been found to overcome the various delivery challenges of these biotherapeutics; these have also been briefly summarized here. Furthermore, the outcomes and progresses that have been made in pre-clinical models and clinical trials have also been presented to review the

  5. Signal-background interference for a singlet spin-0 digluon resonance at the LHC

    CERN Document Server

    Martin, Stephen P

    2016-01-01

    Dijet mass distributions can be used to search for spin-0 resonances that couple to two gluons. I show that there is a substantial impact on such searches from the interference between the resonant signal and the continuum QCD background amplitudes. The signal dijet mass distribution is qualitatively modified by this interference, compared to the naive expectation from considering only the pure resonant contribution, even if the total width of the resonance is minimal and very small compared to the experimental dijet mass resolution. The impact becomes more drastic as the total width of the resonance increases. These considerations are illustrated using examples relevant to the 750 GeV diphoton excess recently observed at the LHC.

  6. Magnetic fringe field interference between the quadrupole and corrector magnets in the CSNS/RCS

    Science.gov (United States)

    Yang, Mei; Kang, Wen; Deng, Changdong; Sun, Xianjing; Li, Li; Wu, Xi; Gong, Lingling; Cheng, Da; Zhu, Yingshun; Chen, Fusan

    2017-03-01

    The Rapid Cycling Synchrotron (RCS) of the China Spallation Neutron Source (CSNS) employs large aperture quadrupole and corrector magnets with small aspect ratios and relatively short iron to iron separations; so the fringe field interference becomes serious which results in integral field strength reduction and extra field harmonics. We have performed 3D magnetic field simulations to investigate the magnetic field interference in the magnet assemblies and made some adjustments on the magnet arrangement. The Fourier analysis is used to quantify the integral gradient reduction and field harmonic changes of the quadrupole magnets. Some magnetic field measurements are undertaken to verify the simulation results. The simulation details and the major results are presented in this paper.

  7. Probing C P violation in h →Z γ with background interference

    Science.gov (United States)

    Farina, Marco; Grossman, Yuval; Robinson, Dean J.

    2015-10-01

    We show that the parity of the h Z γ vertex can be probed by interference between the gluon fusion Higgs production, g g →h →γ Z →γ ℓ+ℓ- , and the background, g g →γ Z →γ ℓ+ℓ-,amplitudes. In the presence of a parity violating h Z γ vertex, this interference alters the kinematic distribution of the leptons and photon compared to Standard Model (SM) expectations. For a Higgs with SM-sized width and couplings, we find that the size of the effect enters at most at the 1 0 -2 level. Such a small effect cannot be seen at the LHC, even with futuristic high luminosities. Should there exist other broader scalar particles with larger production cross-section times branching ratio to Z γ , then the parity structure of their Z γ couplings can be probed with this technique.

  8. The Overall Balance Between Cooperation and Interference for a Class of Wireless Networks

    CERN Document Server

    Altieri, Andrés; Piantanida, Pablo; Galarza, Cecilia

    2012-01-01

    This paper investigates the benefits of cooperation in large wireless networks with multiple sources and relays, where the nodes form an homogeneous Poisson point process. The source nodes may dispose of their nearest neighbor from the set of inactive nodes as their relay. Although cooperation can potentially lead to significant improvements on the asymptotic error probability of a communication pair, relaying causes additional interference in the network, increasing the average noise. We address the basic question: how should source nodes optimally balance cooperation vs. interference to guarantee reliability in all communication pairs. Based on the decode-and-forward (DF) scheme at the relays (which is near optimal when the relays are close to their corresponding sources), we derive closed-form approximations to the upper bounds on the error probability, averaging over all node positions. Surprisingly, in the small node-density regime, there is an almost binary behaviour that dictates --depending on network...

  9. Ground-State Cooling of a Mechanical Oscillator by Interference in Andreev Reflection

    Science.gov (United States)

    Stadler, P.; Belzig, W.; Rastelli, G.

    2016-11-01

    We study the ground-state cooling of a mechanical oscillator linearly coupled to the charge of a quantum dot inserted between a normal metal and a superconducting contact. Such a system can be realized, e.g., by a suspended carbon nanotube quantum dot with a capacitive coupling to a gate contact. Focusing on the subgap transport regime, we analyze the inelastic Andreev reflections which drive the resonator to a nonequilibrium state. For small coupling, we obtain that vibration-assisted reflections can occur through two distinct interference paths. The interference determines the ratio between the rates of absorption and emission of vibrational energy quanta. We show that ground-state cooling of the mechanical oscillator can be achieved for many of the oscillator's modes simultaneously or for single modes selectively, depending on the experimentally tunable coupling to the superconductor.

  10. Probing CP Violation in $h \\to Z\\gamma$ with Background Interference

    CERN Document Server

    Farina, Marco; Robinson, Dean J

    2015-01-01

    We show that the parity of the $h Z\\gamma$ vertex can be probed by interference between the gluon fusion Higgs production, $gg \\to h \\to \\gamma Z \\to \\gamma \\ell^+\\ell^-$, and the background, $gg \\to \\gamma Z \\to \\gamma \\ell^+\\ell^-$, amplitudes. In the presence of a parity violating $hZ\\gamma$ vertex, this interference alters the kinematic distribution of the leptons and photon compared to Standard Model (SM) expectations. For a Higgs with SM-sized width and couplings, we find that the size of the effect enters at most at the $10^{-2}$ level. Such a small effect cannot be seen at the LHC, even with futuristic high luminosities. Should there exist other broader scalar particles with larger production cross-section times branching ratio to $Z\\gamma$, then the parity structure of their $Z\\gamma$ couplings can be probed with this technique.

  11. Small RNA Detection by in Situ Hybridization Methods

    OpenAIRE

    Urbanek, Martyna O.; Nawrocka, Anna U.; Krzyzosiak, Wlodzimierz J.

    2015-01-01

    Small noncoding RNAs perform multiple regulatory functions in cells, and their exogenous mimics are widely used in research and experimental therapies to interfere with target gene expression. MicroRNAs (miRNAs) are the most thoroughly investigated representatives of the small RNA family, which includes short interfering RNAs (siRNAs), PIWI-associated RNA (piRNAs), and others. Numerous methods have been adopted for the detection and characterization of small RNAs, which is challenging due to...

  12. RNA Interference (RNAi) Induced Gene Silencing: A Promising Approach of Hi-Tech Plant Breeding.

    Science.gov (United States)

    Younis, Adnan; Siddique, Muhammad Irfan; Kim, Chang-Kil; Lim, Ki-Byung

    2014-01-01

    RNA interference (RNAi) is a promising gene regulatory approach in functional genomics that has significant impact on crop improvement which permits down-regulation in gene expression with greater precise manner without affecting the expression of other genes. RNAi mechanism is expedited by small molecules of interfering RNA to suppress a gene of interest effectively. RNAi has also been exploited in plants for resistance against pathogens, insect/pest, nematodes, and virus that cause significant economic losses. Keeping beside the significance in the genome integrity maintenance as well as growth and development, RNAi induced gene syntheses are vital in plant stress management. Modifying the genes by the interference of small RNAs is one of the ways through which plants react to the environmental stresses. Hence, investigating the role of small RNAs in regulating gene expression assists the researchers to explore the potentiality of small RNAs in abiotic and biotic stress management. This novel approach opens new avenues for crop improvement by developing disease resistant, abiotic or biotic stress tolerant, and high yielding elite varieties.

  13. Interference of electronic apex locators with implantable cardioverter defibrillators

    NARCIS (Netherlands)

    Idzahi, K.; de Cock, C.C.; Shemesh, H.; Brand, H.S.

    2014-01-01

    Introduction The purpose of this in vitro study was to evaluate the potential electromagnetic interference of electronic apex locators (EALs) on implantable cardioverter defibrillators (ICDs). Methods Four different EALs were tested for their ability to interfere with the correct function of 3 diffe

  14. Quantum Interference and Entanglement Induced by Multiple Scattering of Light

    DEFF Research Database (Denmark)

    Ott, Johan Raunkjær; Mortensen, Asger; Lodahl, Peter

    2010-01-01

    We report on the effects of quantum interference induced by the transmission of an arbitrary number of optical quantum states through a multiple-scattering medium. We identify the role of quantum interference on the photon correlations and the degree of continuous variable entanglement between tw...

  15. Interference patterns and extinction ratio of the diatom Coscinodiscus granii

    DEFF Research Database (Denmark)

    Maibohm, Christian; Friis, Søren Michael Mørk; Ellegaard, M.;

    2015-01-01

    We report experimental and theoretical verification of the nature and position of multiple interference points of visible light transmitted through the valve of the centric diatom species Coscinodiscus granii. Furthermore, by coupling the transmitted light into an optical fiber and moving the dia...... the diatom valve between constructive and destructive interference points, an extinction ratio of 20 dB is shown...

  16. Base band data for testing interference mitigation algorithms

    NARCIS (Netherlands)

    Bell, JF; Hall, PJ; Wilson, WE; Sault, RJ; Smegal, RJ; Smith, MR; van Straten, W; Kesteven, MJ; Ferris, RH; Briggs, FH; Carrad, GJ; Sinclair, MW; Gough, RG; Sarkissian, JM; Bunton, JD; Bailes, M

    Digital signal processing is one of many valuable tools for suppressing unwanted signals or interference. Building hardware processing engines seems to be the way to best implement some classes of interference suppression but is, unfortunately, expensive and time-consuming, especially if several

  17. Transparency induced by two photon interference in a beam splitter

    Institute of Scientific and Technical Information of China (English)

    Wang Kai-Ge; Yang Guo-Jian

    2004-01-01

    We propose a special two-photon state which is completely transparent in a 50/50 beam splitter. This effect is caused by the destructive two-photon interference and shows the signature of photon entanglement. We find that the symmetry of the two-photon spectrum plays the key role for the properties of two-photon interference.

  18. Interference Impacts Working Memory in Mild Cognitive Impairment

    Science.gov (United States)

    Aurtenetxe, Sara; García-Pacios, Javier; del Río, David; López, María E.; Pineda-Pardo, José A.; Marcos, Alberto; Delgado Losada, Maria L.; López-Frutos, José M.; Maestú, Fernando

    2016-01-01

    Mild cognitive impairment (MCI) is considered a transitional stage between healthy aging and dementia, specifically Alzheimer's disease (AD). The most common cognitive impairment of MCI includes episodic memory loss and difficulties in working memory (WM). Interference can deplete WM, and an optimal WM performance requires an effective control of attentional resources between the memoranda and the incoming stimuli. Difficulties in handling interference lead to forgetting. However, the interplay between interference and WM in MCI is not well-understood and needs further investigation. The current study investigated the effect of interference during a WM task in 20 MCIs and 20 healthy elder volunteers. Participants performed a delayed match-to-sample paradigm which consisted in two interference conditions, distraction and interruption, and one control condition without any interference. Results evidenced a disproportionate impact of interference on the WM performance of MCIs, mainly in the presence of interruption. These findings demonstrate that interference, and more precisely interruption, is an important proxy for memory-related deficits in MCI. Thus, the current findings reveal novel evidence regarding the causes of WM forgetting in MCI patients, associated with difficulties in the mechanisms of attentional control. PMID:27790082

  19. Interference impacts working memory in mild cognitive impairment

    Directory of Open Access Journals (Sweden)

    Sara Aurtenetxe

    2016-10-01

    Full Text Available Mild cognitive impairment (MCI is considered a transitional stage between healthy aging and dementia, specifically Alzheimer’s disease (AD. The most common cognitive impairment of MCI includes episodic memory loss and difficulties in working memory (WM. Interference can deplete WM, and an optimal WM performance requires an effective control of attentional resources between the memoranda and the incoming stimuli. Difficulties in handling interference lead to forgetting. However, the interplay between interference and WM in MCI is not well understood and needs further investigation. The current study investigated the effect of interference during a WM task in 20 MCIs and 20 healthy elder volunteers. Participants performed a delayed match-to-sample paradigm which consisted in two interference conditions, distraction and interruption, and one control condition without any interference. Results evidenced a disproportionate impact of interference on the WM performance of MCIs, mainly in the presence of interruption. These findings demonstrate that interference, and more precisely interruption, is an important proxy for memory-related deficits in MCI. Thus the current findings reveal novel evidence regarding the causes of WM forgetting in MCI patients, associated with difficulties in the mechanisms of attentional control.

  20. Fraunhofer regime of operation for superconducting quantum interference filters

    DEFF Research Database (Denmark)

    Shadrin, A.V.; Constantinian, K.Y.; Ovsyannikov, G.A.;

    2008-01-01

    Series arrays of superconducting quantum interference devices (SQUIDs) with incommensurate loop areas, so-called superconducting quantum interference filters (SQIFs), are investigated in the kilohertz and the gigahertz frequency range. In SQIFs made of high-T-c bicrystal junctions the flux-to-vol...

  1. 47 CFR 15.711 - Interference avoidance mechanisms.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 1 2010-10-01 2010-10-01 false Interference avoidance mechanisms. 15.711... Television Band Devices § 15.711 Interference avoidance mechanisms. (a) Except as provided in § 15.717... mechanism described in paragraph (b) of this section or spectrum sensing described in paragraph (c) of...

  2. Interference-Cancellation Scheme for Multilayer Cellular Systems

    Institute of Scientific and Technical Information of China (English)

    Wei Li; Yue Zhang; LiKe Huang

    2015-01-01

    A 5G network must be heterogeneous and support the co⁃existence of multilayer cells, multiple standards, and multiple applica⁃tion systems. This greatly improves link performance and increases link capacity. A network with co⁃existing macro and pico cells can alleviate traffic congestion caused by multicast or unicast subscribers, help satisfy huge traffic demands, and further extend converge. In order to practically implement advanced 5G technology, a number of technical problems have to be solved, one of which is inter⁃cell interference. A method called Almost Blank Subframe (ABS) has been proposed to mitigate interference;howev⁃er, the reference signal in ABS still causes interference. This paper describes how interference can be cancelled by using the in⁃formation in the ABS. First, the interference⁃signal model, which takes into account channel effect, time and frequency error, is presented. Then, an interference⁃cancellation scheme based on this model is studied. The timing and carrier frequency offset of the interference signal is compensated. Afterwards, the reference signal of the interfering cell is generated locally and the channel response is estimated using channel statistics. Then, the interference signal is reconstructed according to previous estimation of channel, timing, and carrier frequency offset. The interference is mitigated by subtracting the estimated interference signal. Com⁃puter simulation shows that this interference⁃cancellation algorithm significantly improves performance under different channel conditions.

  3. Direct laser interference ablating nanostructures on organic crystals

    NARCIS (Netherlands)

    Fang, Hong-Hua; Ding, Ran; Lu, Shi-Yang; Wang, Lei; Feng, Jing; Chen, Qi-Dai; Sun, Hong-Bo; Fang, Honghua

    2012-01-01

    Two-beam interference ablation of 1,4-Bis(4-methylstyryl) benzene organic crystal by short laser pulses (10 ns, 355 nm) is presented. The influence of laser fluence, interference period, and pulse number on the morphology have been studied. The morphology is closely associated with the molecular int

  4. Base band data for testing interference mitigation algorithms

    NARCIS (Netherlands)

    Bell, JF; Hall, PJ; Wilson, WE; Sault, RJ; Smegal, RJ; Smith, MR; van Straten, W; Kesteven, MJ; Ferris, RH; Briggs, FH; Carrad, GJ; Sinclair, MW; Gough, RG; Sarkissian, JM; Bunton, JD; Bailes, M

    2001-01-01

    Digital signal processing is one of many valuable tools for suppressing unwanted signals or interference. Building hardware processing engines seems to be the way to best implement some classes of interference suppression but is, unfortunately, expensive and time-consuming, especially if several mit

  5. Do marine natural products interfere with prokaryotic AHL regulatory systems?

    DEFF Research Database (Denmark)

    Kjelleberg, S.; Steinberg, P.; Givskov, Michael Christian

    1997-01-01

    signalling system. We demonstrate that halogenated furanones, a class of secondary metabolites produced by the Australian subtidal red alga DeLisea pulchra, interfere with the acylated homoserine lactone (AHL) regulatory system in several Gram-negative bacteria. Furanones were found to interfere with the AHL...

  6. 47 CFR 80.92 - Prevention of interference.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 5 2010-10-01 2010-10-01 false Prevention of interference. 80.92 Section 80.92... MARITIME SERVICES Operating Requirements and Procedures Operating Procedures-General § 80.92 Prevention of...-communication causes interference to a communication which is already in progress, the interfering station...

  7. Ensuring Secure Non-interference of Programs by Game Semantics

    DEFF Research Database (Denmark)

    Dimovski, Aleksandar

    Non-interference is a security property which states that improper information leakages due to direct and indirect flows have not occurred through executing programs. In this paper we investigate a game semantics based formulation of non-interference that allows to perform a security analysis...

  8. Interference Effects in Strong-Field Dissociative Ionization

    DEFF Research Database (Denmark)

    Yue, Lun; Madsen, Lars Bojer

    2015-01-01

    with simple energy conservation arguments. We explain the structures as interferences between wave packets released during different optical cycles, and during the same optical cycle, respectively. Both inter- and intracycle interference structures are clearly visible in the joint energy spectra. The shapes...

  9. Confidence set interference with a prior quadratic bound. [in geophysics

    Science.gov (United States)

    Backus, George E.

    1989-01-01

    Neyman's (1937) theory of confidence sets is developed as a replacement for Bayesian interference (BI) and stochastic inversion (SI) when the prior information is a hard quadratic bound. It is recommended that BI and SI be replaced by confidence set interference (CSI) only in certain circumstances. The geomagnetic problem is used to illustrate the general theory of CSI.

  10. Interferenze Fonologiche e Identificazione Culturale (Phonological Interferences and Cultural Identity).

    Science.gov (United States)

    Pinto, Maria Antonietta; Frassu, Pinuccia

    1991-01-01

    After a brief summary of the literature on interference and code switching, research with adult Sardinians living in Rome is discussed to determine the relationship between dialectal phonological interference and the degree of identification with the new culture. (26 references) (CFM)

  11. Interference Alignment and Fairness Algorithms for MIMO Cognitive Radio Systems

    Directory of Open Access Journals (Sweden)

    Feng Zhao

    2015-01-01

    Full Text Available Interference alignment (IA is an effective technique to eliminate the interference among wireless nodes. In a multiinput multi-output (MIMO cognitive radio system, multiple secondary users can coexist with the primary user without generating any interference by using the IA technology. However, few works have considered the fairness of secondary users. In this paper, not only is the interference eliminated by IA, but also the fairness of secondary users is considered by two kinds of algorithms. Without losing generality, one primary user and K secondary users are considered in the network. Assuming perfect channel knowledge at the primary user, the interference from secondary users to the primary user is aligned into the unused spatial dimension which is obtained by water-filling among primary user. Also, the interference between secondary users can be eliminated by a modified maximum signal-to-interference-plus-noise algorithm using channel reciprocity. In addition, two kinds of fairness algorithms, max-min fairness and proportional fairness, among secondary users are proposed. Simulation results show the effectiveness of the proposed algorithms in terms of suppressed interference and fairness of secondary nodes. What is more, the performances of the two fairness algorithms are compared.

  12. Quantum interference and diffraction of parametric down-converted biphotons

    Indian Academy of Sciences (India)

    Ryosuke Shimizu; Keiichi Edamatsu; Tadashi Itoh

    2002-08-01

    We present two-photon diffraction and interference experiments utilizing parametric down-converted photon pairs (biphotons) and a transmission grating. The biphoton exhibits a diffraction-interference pattern equivalent to an effective single particle with half wavelength of the constituent photons.

  13. Optical interference coatings for optics and photonics [Invited].

    Science.gov (United States)

    Lee, Cheng-Chung

    2013-01-01

    Optical interference coatings play as an important role in the progress in optics and photonics. In this article we give a minireview of the evolution of optical interference coatings from the theory, the design, to the manufacture. Some interesting but challenging topics for the future are also discussed.

  14. Role interference and subjective well-being among expatriate families

    NARCIS (Netherlands)

    Van der Zee, KI; Salome, E

    2005-01-01

    The present study examined the relation of demands and social support, and positive and negative Work-Home (WHI) and Home-Work interference (HWI) with the subjective well-being of expatriates. Moreover, we were also interested in crossover effects of expatriate interference to the subjective wellbei

  15. Review Results on Wing-Body Interference

    Directory of Open Access Journals (Sweden)

    Frolov Vladimir

    2016-01-01

    Full Text Available The paper presents an overview of results for wing-body interference, obtained by the author for varied wing-body combinations. The lift-curve slopes of the wing-body combinations are considered. In this paper a discrete vortices method (DVM and 2D potential model for cross-flow around fuselage are used. The circular and elliptical cross-sections of the fuselage and flat wings of various forms are considered. Calculations showed that the value of the lift-curve slopes of the wing-body combinations may exceed the same value for an isolated wing. This result confirms an experimental data obtained by other authors earlier. Within a framework of the used mathematical models the investigations to optimize the wing-body combination were carried. The present results of the optimization problem for the wing-body combination allowed to select the optimal geometric characteristics for configuration to maximize the values of the lift-curve slopes of the wing-body combination. It was revealed that maximums of the lift-curve slopes for the optimal mid-wing configuration with elliptical cross-section body had a sufficiently large relative width of the body (more than 30% of the span wing.

  16. Separating cyclostationary signals from spectrally overlapping interference

    Institute of Scientific and Technical Information of China (English)

    GUO Jie; LIU Yun; YE Zhi-hui; SONG Tie-cheng; SHEN Lian-feng

    2006-01-01

    This paper studies an algorithm about separating spectmlly overlapping signals using the cyclostationary properties of signals.On the basis of direct sequence spread system (DSSS),frequency shift filter is added into the receiver of the communication system.Although the structure of frequency shift filter is more complicated than the time-domain filter,it uses both time correlations and frequency spectrum correlations so it can achieve better performances on separating the overlapping signals.After the analysis of cyclostationary characteristic and frequency spectrum correlation,the structure of the frequency shift filter can be gained.Then,a self-adaptive algorithm is utilized for the purpose of achieving optimum multidimensional tap weights of frequency shift components.The simulation results indicate that this method can efficiently separate overlapping signals,and its error rate is lower than the time-domain filter or DSSS system by two orders of magnitude on the condition that high-power interference is added into the system.

  17. Instantaneous Relaying: Optimal Strategies and Interference Neutralization

    CERN Document Server

    Ho, Zuleita

    2012-01-01

    In a multi-user wireless network equipped with multiple relay nodes, some relays are more intelligent than other relay nodes. The intelligent relays are able to gather channel state information, perform linear processing and forward signals whereas the dumb relays is only able to serve as amplifiers. As the dumb relays are oblivious to the source and destination nodes, the wireless network can be modeled as a relay network with *smart instantaneous relay* only: the signals of source-destination arrive at the same time as source-relay-destination. Recently, instantaneous relaying is shown to improve the degrees-of-freedom of the network as compared to classical cut-set bound. In this paper, we study an achievable rate region and its boundary of the instantaneous interference relay channel in the scenario of (a) uninformed non-cooperative source-destination nodes (source and destination nodes are not aware of the existence of the relay and are non-cooperative) and (b) informed and cooperative source-destination...

  18. Fiber Optic Pressure Sensor using Multimode Interference

    Energy Technology Data Exchange (ETDEWEB)

    Ruiz-Perez, V I; Sanchez-Mondragon, J J [INAOE, Apartado Postal 51 y 216, Puebla 72000 (Mexico); Basurto-Pensado, M A [CIICAp, Universidad Autonoma del Estado de Morelos (Mexico); LiKamWa, P [CREOL, University of Central Florida, Orlando, FL 32816 (United States); May-Arrioja, D A, E-mail: iruiz@inaoep.mx, E-mail: mbasurto@uaem.mx, E-mail: delta_dirac@hotmail.com, E-mail: daniel_may_arrioja@hotmail.com [UAT Reynosa Rodhe, Universidad Autonoma de Tamaulipas (Mexico)

    2011-01-01

    Based on the theory of multimode interference (MMI) and self-image formation, we developed a novel intrinsic optical fiber pressure sensor. The sensing element consists of a section of multimode fiber (MMF) without cladding spliced between two single mode fibers (SMF). The MMI pressure sensor is based on the intensity changes that occur in the transmitted light when the effective refractive index of the MMF is changed. Basically, a thick layer of Polydimethylsiloxane (PDMS) is placed in direct contact with the MMF section, such that the contact area between the PDMS and the fiber will change proportionally with the applied pressure, which results in a variation of the transmitted light intensity. Using this configuration, a good correlation between the measured intensity variations and the applied pressure is obtained. The sensitivity of the sensor is 3 {mu}V/psi, for a range of 0-60 psi, and the maximum resolution of our system is 0.25 psi. Good repeatability is also observed with a standard deviation of 0.0019. The key feature of the proposed pressure sensor is its low fabrication cost, since the cost of the MMF is minimal.

  19. Environmental Factors that Interfere in the Germination

    Directory of Open Access Journals (Sweden)

    Lisiane de Souza

    2014-12-01

    Full Text Available This paper refers to the application of experiments with sixth graders of elementary school, aiming motivation, skills development focused on observation, interpersonal relationships in teams, related to the various forms of language skills, as well to identify and resume misconceptions about the external (environmental factors required for seed germination, in order that the contents developed this year refer to the study of the earth, soil, water and air, among others, and that many students do not understand all the concepts and the importance of these factors for the existence of living beings. The experiments were organized in two stages, first to observe the influence of soil and another moment to observe the interference of water, air and light. The temperature impractical activities were conducted, however, during the observation period (three weeks experiments remained in a controlled environment in the science laboratory. For the experiments we used materials easily found in commerce, some recycled; students were organized into six teams, which improved the data collection, the maintenance of the experiments, the calculations of the percentages, and the producing of report. Many of these contents had not yet been studied in other disciplines, but were developed in the discipline of science, respecting prior knowledge and cognitive abilities. The use of experiments was effective for the construction of new knowledge and to develop skills necessary to start the search.

  20. p53 gene therapy using RNA interference.

    Science.gov (United States)

    Berindan-Neagoe, I; Balacescu, O; Burz, C; Braicu, C; Balacescu, L; Tudoran, O; Cristea, V; Irimie, A

    2009-09-01

    p53 gene, discovered almost 35 years ago, keeps the main role in cell cycle control, apoptosis pathways and transcription. p53 gene is found mutated in more than 50% of all human cancers in different locations. Many structures from viral to non viral were designed to incorporate and deliver in appropriate conditions forms of p53 gene or its transcripts, systemically to target tumor cells and to eliminate them through apoptosis or to restore the normal tumor suppressor gene role. Each delivery system presents advantages and low performance in relation to immune system recognition and acceptance. One of the major discoveries in the last years, silencing of RNA, represents a powerful tool for inhibiting post transcriptional control of gene expression. According to several studies, the RNA silencing technology for p53 transcripts together with other carriers or transporters at nano level can be used for creating new therapeutic models. RNA interference for p53 uses different double-stranded (ds) molecules like short interfering (si) RNA and, despite the difficulty of introducing them into mammalian cells due to immune system response, it can be exploited in cancer therapy.