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Sample records for 1-year extension study

  1. Deferasirox effectively reduces iron overload in non-transfusion-dependent thalassemia (NTDT) patients: 1-year extension results from the THALASSA study.

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    Taher, Ali T; Porter, John B; Viprakasit, Vip; Kattamis, Antonis; Chuncharunee, Suporn; Sutcharitchan, Pranee; Siritanaratkul, Noppadol; Galanello, Renzo; Karakas, Zeynep; Lawniczek, Tomasz; Habr, Dany; Ros, Jacqueline; Zhu, Zewen; Cappellini, M Domenica

    2013-11-01

    Patients with non-transfusion-dependent thalassemia (NTDT) often develop iron overload that requires chelation to levels below the threshold associated with complications. This can take several years in patients with high iron burden, highlighting the value of long-term chelation data. Here, we report the 1-year extension of the THALASSA trial assessing deferasirox in NTDT; patients continued with deferasirox or crossed from placebo to deferasirox. Of 133 patients entering extension, 130 completed. Liver iron concentration (LIC) continued to decrease with deferasirox over 2 years; mean change was -7.14 mg Fe/g dry weight (dw) (mean dose 9.8 ± 3.6 mg/kg/day). In patients originally randomized to placebo, whose LIC had increased by the end of the core study, LIC decreased in the extension with deferasirox with a mean change of -6.66 mg Fe/g dw (baseline to month 24; mean dose in extension 13.7 ± 4.6 mg/kg/day). Of 166 patients enrolled, 64 (38.6 %) and 24 (14.5 %) patients achieved LIC Deferasirox progressively decreases iron overload over 2 years in NTDT patients with both low and high LIC. Safety profile of deferasirox over 2 years was consistent with that in the core study.

  2. A 1-year Study of Eye Trauma at Farabi Hospital

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    J. Faraji Oskooie

    1998-04-01

    Full Text Available The author conducted 1-year study investigating the causation and management of eye trauma at Farabi Eye' center. All patients sustaining eye injuries who were evaluated by ophthalmology service over one year interval were included."n. A formal questionnaire was completed with details of the injuiy being obtained. An ophthalmologic examination was performed on each patient, and examination findings and diagnostic tests obtained, diagnosis and treatment were recorded and analyzed."nNine hundreds and sixty-one injuries (65% occured in males and 503 (35% in females. The average age was 30 years. This study included 1464 eye injuries."nFour handreds and eighty-five (nearly 30% of patients were in pediatric age group. Seventy percent of all patients were admitted within 24 hours of their injury. Fourty percent of all injuries occurred in the street, 30% at home, 15% at the work place , the rest either in school or sport field."nAmong those older than 65 years of age, 70% of injuries were the result of fall. Seventy percent of all eye injuries were caused by blunt trauma. Diagnosis and management were recorded."nConclusions : Tehran and other metropolitans population is more likely to sustain eye trauma as the result of an assault and is less likely to be involved in a work- or sports-related one."nGiven poor compliance without patient management and follow-up, aggressive primary management may be indicated to optimize visual outcome

  3. Falls prediction in elderly people : A 1-year prospective study

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    Swanenburg, Jaap; de Bruin, Eling D.; Uebelhart, Daniel; Mulder, Theo

    2010-01-01

    The aim of the present study was to determine whether force plate variables in single- and dual-task situations are able to predict the risk of multiple falls in a community-dwelling elderly population. Two hundred and seventy elderly persons (225 females, 45 males; age, 73 7 years) performed balanc

  4. Changes in flow experience among occupational therapy students: a 1-year longitudinal study

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    Kazuki Hirao

    2014-07-01

    Full Text Available Purpose: The purpose of this 1-year longitudinal study is to investigate the change in flow experience among occupational therapy students (OTS. Methods: In December 2012, we prospectively recruited 97 OTS from the Department of Occupational Therapy, Kibi International University. To assess flow experience in daily life, we used the Flow Experience Checklist. Results: The dataset included 87 OTS, of which 75 participated in the assessment at 1 year (follow-up rate, 86.2%. The mean age at baseline of 45 male and 30 female OTS was 19.59±1.1 years (range, 18 to 24 years. A comparison of the ‘frequency of flow experience’ showed significant differences between baseline values and those after 1 year (December 2013 among male OTS (P<0.05. Conclusion: The present results indicate that, for male OTS, the frequency of flow was significantly reduced after 1 year compared with baseline values. This finding suggests the need for further education to increase the frequency of flow among male OTS.

  5. Mandibular Overdentures Supported by 6-mm Dental Implants : A 1-Year Prospective Cohort Study

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    Gulje, Felix; Raghoebar, Gerry M.; Ter Meulen, Jan-Willem P.; Vissink, Arjan; Meijer, Henny J. A.; Guljé, Felix

    2012-01-01

    Background: The extremely resorbed edentulous mandible, with a bone height of 8 mm or less, is still a challenge in implant dentistry. Recently, dental implants of 6 mm in length have been developed. Purpose: The purpose of this 1-year prospective cohort study was to evaluate treatment outcome of ma

  6. Efficacy of risedronate in men with primary and secondary osteoporosis: results of a 1-year study.

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    Ringe, J D; Faber, H; Farahmand, P; Dorst, A

    2006-03-01

    Osteoporosis is prevalent in men with an estimated one in eight men older than 50 years suffering from osteoporotic fracture, and a higher mortality rate after fracture among men compared with women. There are few approved therapies for osteoporosis in men. This observational study assesses the efficacy and safety of risedronate in the treatment of men with primary and secondary osteoporosis. A single-center, open label, randomized, prospective 1-year study was conducted in men with primary or secondary osteoporosis. Patients were randomized to risedronate (risedronate 5 mg/day plus calcium 1,000 mg/day and vitamin D 800 IU/day) or control groups (alfacalcidol 1 mug/day plus calcium 500 mg/day or vitamin D 1,000 IU/day plus calcium 800 mg/day). Bone mineral density (BMD) measurements, X-rays of the spine, a medical history and physical exam, and patient self-assessments of back pain were performed at baseline and 12 months. Blinded semi-quantitative fracture assessment was conducted by a radiologist. A total of 316 men with osteoporosis were enrolled in the trial (risedronate, n=158; control, n=158). At 1 year lumbar spine BMD increased by 4.7% in the risedronate group versus an increase of 1.0% in the control group (P<0.001). Significant increases in BMD at the total hip and femoral neck were also observed with risedronate compared with the control group. The incidence of new vertebral fracture in the risedronate group was reduced by 60% versus the control group (P=0.028). Daily treatment with risedronate for 12 months significantly increased BMD at the lumbar spine, femoral neck and total hip and significantly reduced the incidence of new vertebral fractures. This is the first prospective, randomized, controlled trial to demonstrate a significant reduction in vertebral fractures in 1 year in men with primary or secondary osteoporosis.

  7. Cognitive and affective assessment in day care versus institutionalized elderly patients: a 1-year longitudinal study

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    Maseda A

    2014-06-01

    Full Text Available Ana Maseda, Aránzazu Balo, Laura Lorenzo–López, Leire Lodeiro–Fernández, José Luis Rodríguez–Villamil, José Carlos Millán–CalentiGerontology Research Group, Faculty of Health Sciences, University of A Coruña, A Coruña, SpainPurpose: Cognitive decline and depression are two common mental health problems that may create a need for long-term care among the elderly. In the last decade, the percentage of older adults who receive health care in nursing homes, day care centers, or home support services has increased in Europe. The objectives of this descriptive and nonrandomized longitudinal study were to evaluate and to compare the cognitive and affective evolution of day care versus institutionalized older patients through a 1-year period, and to assess the presence of cognitive and affective impairment as a function of the care setting.Patients and methods: Ninety-four patients were assessed at baseline, and 63 (67.0% were reassessed 1 year later. Neuropsychological assessment included measures of cognitive performance (general cognitive status, visuospatial, and language abilities and affective status (depressive symptoms.Results: Our findings indicated that the majority of the participants (day care and institutionalized patients had mild–moderate cognitive impairment at baseline, which significantly increased in both groups after 1-year follow-up. However, the rate of change in global cognitive function did not significantly differ between groups over time. Regarding language abilities, naming function maintained among day care patients in comparison with institutionalized patients, who showed worse performance at follow-up. As regards to affective status, results revealed that institutionalized patients had a significant reduction in depressive symptoms at follow-up, when compared to day care patients. Results also highlight the high frequency of cognitive impairment and depressive symptoms regardless of the care setting

  8. Optic neuritis in Hong Kong: a 1-year follow-up study.

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    Lau, Patrick P K; Yau, Gordon S K; Lee, Jacky W Y; Wong, Winnie W Y; Tam, Victor T Y; Chan, Eric Y T; Tse, Doris M W; Yuen, Can Y F

    2015-06-01

    To investigate the etiology and prevalence of optic neuritis in a Chinese population. This was a single centre prospective cohort study. Consecutive patients with either a first or recurrent attack of optic neuritis from November 2010 to December 2011 were recruited from a district hospital in Hong Kong Special Administrative Region, China. All patients underwent serology testing for NMO (neuromyelitis optica) IgG; oligoclonal bands from lumbar puncture; computer tomography and contrast magnetic resonance imaging (MRI) of the brain and orbit as well as visual field; and optical coherence tomography testing. Patients were followed up for 1 year after the initial attack. 30 optic neuritis subjects were recruited. 73.3 % (22/30) remain as clinical isolated syndrome (CIS) after 1-year follow-up. 10 % (3/30) patients developed multiple sclerosis. 10 % (3/30) were diagnosed with NMO and 6.7 % (2/30) with NMO-spectrum disorder. The majority of acute unilateral optic neuritis in Chinese was CIS in origin although a fraction does progress to develop MS or NMO-related disorders. Clinicians should be aware of the associations and offer appropriate systemic workups.

  9. Efficacy and safety of tiotropium Respimat SMI in COPD in two 1-year randomized studies.

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    Bateman, Eric; Singh, Dave; Smith, David; Disse, Bernd; Towse, Lesley; Massey, Dan; Blatchford, Jon; Pavia, Demetri; Hodder, Rick

    2010-08-09

    Two 1-year studies evaluated the long-term efficacy and safety of tiotropium 5 or 10 microg versus placebo, inhaled via the Respimat Soft Mist Inhaler (SMI). The two studies were combined and had 4 co-primary endpoints (trough FEV(1) response, Mahler Transition Dyspnea Index [TDI] and St George's Respiratory Questionnaire scores all at week 48, and COPD exacerbations per patient-year). A total of 1990 patients with COPD participated (mean FEV(1): 1.09 L). The mean trough FEV(1) response of tiotropium 5 or 10 microg relative to placebo was 127 or 150 mL, respectively (both P SMI 5 microg demonstrated sustained improvements in patients with COPD relative to placebo and similar to the 10 microg dose but with a lower frequency of anticholinergic adverse events.

  10. Whooping cough in South-East Romania: a 1-year study.

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    Dinu, Sorin; Guillot, Sophie; Dragomirescu, Cristiana Cerasella; Brun, Delphine; Lazăr, Stefan; Vancea, Geta; Ionescu, Biatrice Mariana; Gherman, Mariana Felicia; Bjerkestrand, Andreea-Florina-Dana; Ungureanu, Vasilica; Guiso, Nicole; Damian, Maria

    2014-03-01

    The incidence of whooping cough in Romania is substantially underestimated, and, as noted by the health authorities, this is mostly due to the lack of both awareness and biological diagnosis. We conducted a 1-year study in Bucharest in order to assess the circulation of Bordetella pertussis, the main etiological agent of whooping cough. Fifty-one subjects suspected of whooping cough were enrolled. Culture, real-time PCR, and enzyme-linked immunosorbent assay were used for laboratory diagnosis. Whooping cough patients (63%) were distributed among all age groups, and most were unvaccinated, incompletely vaccinated, or had been vaccinated more than 5 years previously. Bordetella holmesii DNA was detected in 22% of the bordetellosis cases; these patients included adults; teenagers; and, surprisingly, young children. B. pertussis isolates were similar to the clinical isolates currently circulating elsewhere in Europe. One isolate does not express pertactin, an antigen included in some acellular pertussis vaccines.

  11. Latent transition models to study women's changing of dietary patterns from pregnancy to 1 year postpartum.

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    Sotres-Alvarez, Daniela; Herring, Amy H; Siega-Riz, Anna-Maria

    2013-04-15

    Latent class models are useful for classifying subjects by dietary patterns. Our goals were to use latent transition models to identify dietary patterns during pregnancy and postpartum, to estimate the prevalence of these dietary patterns, and to model transition probabilities between dietary patterns as a function of covariates. Women who were enrolled in the Pregnancy, Infection, and Nutrition Study (University of North Carolina, 2000-2005) were followed for 1 year postpartum, and their diets were assessed in the second trimester and at 3 and 12 months postpartum (n = 519, 484, and 374, respectively) by using a food frequency questionnaire. After adjusting for energy intake, parity, smoking status, race, and education, we identified 3 dietary patterns and named them "prudent," "health conscious Western," and "Western." Nulliparas were 2.9 and 2.1 times more likely to be in the "prudent" class than the "health conscious Western" or the "Western" class, respectively. The 3 dietary patterns were very stable, with the "health conscious Western" class being the least stable; the probability for staying in the same class was 0.74 and 0.87 at 3 and 12 months postpartum, respectively. Breastfeeding mothers were more likely than nonbreastfeeding mothers to switch dietary pattern class (P = 0.0286). Except for breastfeeding mothers, most women did not switch dietary patterns from pregnancy to postpartum.

  12. Increased Cardiovascular Events and Subclinical Atherosclerosis in Rheumatoid Arthritis Patients: 1 Year Prospective Single Centre Study

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    Ruscitti, Piero; Cipriani, Paola; Masedu, Francesco; Romano, Silvio; Berardicurti, Onorina; Liakouli, Vasiliki; Carubbi, Francesco; Di Benedetto, Paola; Alvaro, Saverio; Penco, Maria; Valenti, Marco; Giacomelli, Roberto

    2017-01-01

    Objectives Several studies showed the close relationship between Rheumatoid Arthritis (RA) and cerebro-cardiovascular events (CVEs) and subclinical atherosclerosis. In this study, we investigated the occurrence of CVEs and subclinical atherosclerosis during the course of RA and we evaluated the possible role of both traditional cardiovascular (CV) and disease related risk factors to predict the occurrence of new CVEs and the onset of subclinical atherosclerosis. Methods We designed a single centre, bias-adjusted, prospective, observational study to investigate, in a homogeneous subset of RA patients, the occurrence of new onset of CVEs and subclinical atherosclerosis. Statistical analyses were performed to evaluate the role of traditional CV and disease-related risk factors to predict the occurrence of new CVEs and subclinical atherosclerosis. Results We enrolled 347 RA patients prospectively followed for 12 months. An increased percentage of patients experienced CVEs, developed subclinical atherosclerosis and was affected by systemic arterial hypertension (SAH), type 2 diabetes mellitus and metabolic syndrome (MS), at the end of follow up. Our analysis showed that the insurgence of both SAH and MS, during the follow up, the older age, the CVE familiarity and the lack of clinical response, were associated with a significantly increased risk to experience CVEs and to develop subclinical atherosclerosis. Conclusions Our study quantifies the increased expected risk for CVEs in a cohort of RA patients prospectively followed for 1 year. The occurrence of both new CVEs and subclinical atherosclerosis in RA patients may be explained by inflammatory burden as well as traditional CV risk factors. PMID:28103312

  13. Cow's milk protein intolerance in infants under 1 year of age: a prospective epidemiological study.

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    Schrander, J J; van den Bogart, J P; Forget, P P; Schrander-Stumpel, C T; Kuijten, R H; Kester, A D

    1993-08-01

    Incidence and clinical manifestation of cow's milk protein intolerance (CMPI) were studied in 1158 unselected newborn infants followed prospectively from birth to 1 year of age. No food changes were required in 914 infants who were used as healthy controls. When CMPI was suspected (211 infants), diagnostic dietary interventions according to a standard protocol were performed. After exclusion of lactose intolerance, two positive cow's milk elimination/challenge tests were considered diagnostic of CMPI. Two hundred and eleven symptomatic infants were examined for possible CMPI. A large group of 80 infants improved on a lactose reduced formula. In 87/211 infants CMPI was excluded (sick controls). Finally CMPI was proven in 26 infants. The calculated incidence rate for CMPI was 2.8%. The principal symptoms in infants with CMPI were gastrointestinal, dermatological and respiratory in 50%, 31% and 19% respectively. A positive family history for atopy (first or second degree relatives) was more frequent in either CMPI infants (65%), or sick controls (63%) when compared to either healthy controls (35%) or infants improving on a low lactose formula (51%). Differences between patients with CMPI and sick controls were only found for the presence of atopy in at least 2 first degree relatives [(5/26 in CMPI infants and 4/87 in sick controls (P < 0.05)] and for multiorgan involvement [10/26 infants with CMPI as opposed to 12/87 in the sick control group (P < 0.02)]. These statistical differences are too weak to be of clinical value.

  14. Effectiveness of a multidisciplinary heart failure disease management programme on 1-year mortality: Prospective cohort study.

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    Laborde-Castérot, Hervé; Agrinier, Nelly; Zannad, Faiez; Mebazaa, Alexandre; Rossignol, Patrick; Girerd, Nicolas; Alla, François; Thilly, Nathalie

    2016-09-01

    We performed a multicenter prospective observational cohort study (Epidémiologie et Pronostic de l'Insuffisance Cardiaque Aiguë en Lorraine, Epidemiology and Prognosis of Acute Heart Failure in Lorraine [EPICAL2]) to evaluate the effectiveness on mortality of a community-based multidisciplinary disease management programme (DMP) for heart failure (HF) patients.Between October 2011 and October 2012, 1816 patients, who were hospitalized for acute HF or who developed acute HF during a hospitalization, were included from 21 hospitals in a northeast region of France. At hospital admission, their mean age was 77.3 (standard deviation [SD] 11.6) years and mean left ventricular ejection fraction was 45.0 (SD 16.0)%. A subset of patients were enrolled in a multidimensional DMP for HF (n = 312, 17.2%), based on structured patient education, home monitoring visits by HF-trained nurses, and automatic alerts triggered by significant clinical and biological changes to the patient. The DMP involved general practitioners, nurses, and cardiologists collaborating via an individual web-based medical electronic record. The outcome was all-cause mortality from the 3rd to the 12th month after discharge. During the follow-up, a total of 377 (20.8%) patients died: 321 (21.3%) in the control group and 56 (17.9%) in the DMP group. In a propensity score analysis, DMP was associated with lower 1-year all-cause mortality (hazard ratio 0.65, 95% CI 0.46-0.92). Instrumental variable analysis gave similar results (hazard ratio 0.56, 0.27-1.16).In a real world setting, a multidimensional DMP for HF with structured patient education, home nurse monitoring, and appropriate physician alerts may improve survival when implemented after discharge from hospitalization due to worsening HF.

  15. A 1-year time course study of the relaxation times and histology for irradiated rat lungs

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    Shioya, S.; Haida, M.; Fukuzaki, M.; Ono, Y.; Tsuda, M.; Ohta, Y.; Yamabayashi, H. (Tokai Univ. School of Medicine, Kanagawa (Japan))

    1990-05-01

    To investigate the NMR relaxation times for irradiated rat lung tissue, we measured T1 and T2 at 11 different times during the injury's 1-year time course. A biexponential analysis of T2 was used to determine T2 fast (T2f) and T2 slow (T2s). In addition, we measured water content and correlated changes in the relaxation times with pathological changes. The correlation indicates the following: (1) Shortly after irradiation, the biexponential T2 decay for 1/3 of the samples became monoexponential and there were no noticeable pathological changes observed using light microscopy. (2) During radiation pneumonitis, T2f and T2s were prolonged. This accompanied acute edematous changes and inflammatory cell infiltration. (3) Finally, during radiation fibrosis T1 shortened and collagen increased. We observed no significant correlation between relaxation time changes and water content changes throughout the 1-year time course.

  16. A prospective study of the 1-year incidence of fibromyalgia after acute whiplash injury

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    Ferrari, Robert

    2015-01-01

    Objective To measure the 1-year incidence of fibromyalgia in a cohort of acute whiplash-injured participants. Methods Consecutive acute patients with whiplash were assessed via the 2010 Modified American College of Rheumatology (ACR) criteria for fibromyalgia at 3 months, 6 months and 1 year postinjury. At each of these follow-up points, participants were also examined for recovery from whiplash injury. Results Of an initial 268 participants, data on recovery was available for 264 participant...

  17. Impact of Different Childhood Adversities on 1-Year Outcomes of Psychotic Disorder in the Genetics and Psychosis Study.

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    Trotta, Antonella; Murray, Robin M; David, Anthony S; Kolliakou, Anna; O'Connor, Jennifer; Di Forti, Marta; Dazzan, Paola; Mondelli, Valeria; Morgan, Craig; Fisher, Helen L

    2016-03-01

    While the role of childhood adversity in increasing the risk of psychosis has been extensively investigated, it is not clear what the impact of early adverse experiences is on the outcomes of psychotic disorders. Therefore, we investigated associations between childhood adversity and 1-year outcomes in 285 first-presentation psychosis patients. Exposure to childhood adversity prior to 17 years of age was assessed using the Childhood Experience of Care and Abuse Questionnaire. Data on illness course, symptom remission, length of psychiatric hospitalization, compliance with medication, employment, and relationship status were extracted from clinical records for the year following first contact with mental health services for psychosis. Seventy-one percent of patients reported exposure to at least 1 type of childhood adversity (physical abuse, sexual abuse, parental separation, parental death, disrupted family arrangements, or being taken into care). No robust associations were found between childhood adversity and illness course or remission. However, childhood physical abuse was associated with almost 3-fold increased odds of not being in a relationship at 1-year follow-up compared to patients who did not report such adverse experiences. There was also evidence of a significant association between parental separation in childhood and longer admissions to psychiatric wards during 1-year follow-up and 2-fold increased odds of noncompliance with medication compared to those not separated from their parents. Therefore, our findings suggest that there may be some specificity in the impact of childhood adversity on service use and social functioning among psychosis patients over the first year following presentation to mental health services.

  18. Does Sensitivity to Orthographic Regularities Influence Reading and Spelling Acquisition? A 1-Year Prospective Study

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    Rothe, Josefine; Schulte-Körne, Gerd; Ise, Elena

    2014-01-01

    Recent studies focused on the influence of orthographic processing on reading and spelling performance. It was found that orthographic processing is an independent predictor of reading and spelling performance in different languages and children of different ages. This study investigated sensitivity to orthographic regularities in German-speaking…

  19. Factors Influencing Rehospitalisation of Patients with Schizophrenia in Japan: A 1-year Longitudinal Study

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    Takeshi Shimada

    2016-12-01

    Conclusion: This study provided preliminary support for the finding that individualized occupational therapy and proper adherence to outpatient treatment and medication are associated with reducing the rehospitalisation of patients with schizophrenia in Japan.

  20. Pragmatic Functions in Late Talkers: A 1-Year Follow-Up Study

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    MacRoy-Higgins, Michelle; Kliment, Sarah

    2017-01-01

    This study analyzed spontaneous language samples of three-year-olds with a history of expressive language delay (late talkers) and age-matched controls using Dore's Conversational Acts analysis (1978) and Mean Length of Utterance (MLU; Brown, 1973). Differences were observed between groups in utterances classified as organizational device and…

  1. Video game addiction and college performance among males: results from a 1 year longitudinal study.

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    Schmitt, Zachary L; Livingston, Michael G

    2015-01-01

    This study explored the pattern of video game usage and video game addiction among male college students and examined how video game addiction was related to expectations of college engagement, college grade point average (GPA), and on-campus drug and alcohol violations. Participants were 477 male, first year students at a liberal arts college. In the week before the start of classes, participants were given two surveys: one of expected college engagement, and the second of video game usage, including a measure of video game addiction. Results suggested that video game addiction is (a) negatively correlated with expected college engagement, (b) negatively correlated with college GPA, even when controlling for high school GPA, and (c) negatively correlated with drug and alcohol violations that occurred during the first year in college. Results are discussed in terms of implications for male students' engagement and success in college, and in terms of the construct validity of video game addiction.

  2. Diffusion tensor imaging study of pediatric patients with congenital hydrocephalus: 1-year postsurgical outcomes.

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    Mangano, Francesco T; Altaye, Mekibib; McKinstry, Robert C; Shimony, Joshua S; Powell, Stephanie K; Phillips, Jannel M; Barnard, Holly; Limbrick, David D; Holland, Scott K; Jones, Blaise V; Dodd, Jonathan; Simpson, Sarah; Mercer, Deanna; Rajagopal, Akila; Bidwell, Sarah; Yuan, Weihong

    2016-09-01

    OBJECTIVE The purpose of this study was to investigate white matter (WM) structural abnormalities using diffusion tensor imaging (DTI) in children with hydrocephalus before CSF diversionary surgery (including ventriculoperitoneal shunt insertion and endoscopic third ventriculostomy) and during the course of recovery after surgery in association with neuropsychological and behavioral outcome. METHODS This prospective study included 54 pediatric patients with congenital hydrocephalus (21 female, 33 male; age range 0.03-194.5 months) who underwent surgery and 64 normal controls (30 female, 34 male; age range 0.30-197.75 months). DTI and neurodevelopmental outcome data were collected once in the control group and 3 times (preoperatively and at 3 and 12 months postoperatively) in the patients with hydrocephalus. DTI measures, including fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD) values were extracted from the genu of the corpus callosum (gCC) and the posterior limb of internal capsule (PLIC). Group analysis was performed first cross-sectionally to quantify DTI abnormalities at 3 time points by comparing the data obtained in the hydrocephalus group for each of the 3 time points to data obtained in the controls. Longitudinal comparisons were conducted pairwise between different time points in patients whose data were acquired at multiple time points. Neurodevelopmental data were collected and analyzed using the Adaptive Behavior Assessment System, Second Edition, and the Bayley Scales of Infant Development, Third Edition. Correlation analyses were performed between DTI and behavioral measures. RESULTS Significant DTI abnormalities were found in the hydrocephalus patients in both the gCC (lower FA and higher MD, AD, and RD) and the PLIC (higher FA, lower AD and RD) before surgery. The DTI measures in the gCC remained mostly abnormal at 3 and 12 months after surgery. The DTI abnormalities in the PLIC were

  3. DTI study of Children with Congenital Hydrocephalus: 1 Year Post-Surgical Outcomes

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    Mangano, Francesco T.; Altaye, Mekibib; McKinstry, Robert C.; Shimony, Joshua S.; Powell, Stephanie K.; Phillips, Jannel M.; Barnard, Holly; Limbrick, David D.; Holland, Scott K.; Jones, Blaise V.; Dodd, Jonathon; Simpson, Sarah; Deanna, Mercer; Rajagopal, Akila; Bidwell, Sarah; Yuan, Weihong

    2016-01-01

    Object To investigate white matter structural abnormalities using diffusion tensor imaging (DTI) in children with hydrocephalus before CSF diversionary surgery (including ventriculoperitoneal shunting and endoscopic third ventriculoscopy) and the course of recovery post-surgery in association with neuropsychological and behavioral outcome. Methods This was a prospective study that included 54 children with congenital hydrocephalus (21F/33M; age range: 0.03–194.5 months) who underwent surgery and 64 normal controls (30F/34M, age range: 0.30–197.75 months). DTI and neurodevelopmental outcome data were collected once in the control group and at pre-surgery, 3-month, and 12-month post-surgery in the patients. DTI measures, including fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD) values were extracted from the genu of corpus callosum (gCC) and the posterior limb of internal capsule (PLIC). Group analysis was performed first cross-sectionally to quantify DTI abnormalities at three time points by comparing the controls and the patients group at the three time points separately. Longitudinal comparisons were conducted pairwise between different time points in patients whose data were acquired at multiple time points. Neurodevelopmental data were collected and analyzed using the Adaptive Behavior Assessment System, Second Edition (ABAS-II) and the Bayley Scales of Infant Development, Third Edition (Bayley-III). Correlation analyses were performed between DTI and behavioral outcomes. Results Significant DTI abnormalities were found in both the gCC (lower FA and higher MD, AD, and RD) and the PLIC (higher FA, lower AD and RD) at pre-surgery. The DTI measures in the gCC remained mostly abnormal at 3-month and 12-month post-surgery. The DTI abnormalities in the PLIC were significant in FA and AD at 3-month post-surgery but did nor persist when tested at 12-month post-surgery. Significant longitudinal DTI changes in the

  4. A longitudinal, event-related potential pilot study of adult obsessive-compulsive disorder with 1-year follow-up

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    Yamamuro K

    2016-09-01

    Full Text Available Kazuhiko Yamamuro,1 Koji Okada,2 Naoko Kishimoto,1 Toyosaku Ota,1 Junzo Iida,3 Toshifumi Kishimoto1 1Department of Psychiatry, Nara Medical University School of Medicine, 2Department of Psychiatry, Jingumaecocorono-Clinic, 3Faculty of Nursing, Nara Medical University School of Medicine, Kashihara, Japan Aim: Earlier brain imaging research studies have suggested that brain abnormalities in obsessive-compulsive disorder (OCD normalize as clinical symptoms improve. However, although many studies have investigated event-related potentials (ERPs in patients with OCD compared with healthy control subjects, it is currently unknown whether ERP changes reflect pharmacological and psychotherapeutic effects. As such, the current study examined the neurocognitive components of OCD to elucidate the pathophysiological abnormalities involved in the disorder, including the frontal-subcortical circuits.Methods: The Yale-Brown Obsessive-Compulsive Scale was used to evaluate 14 adult patients with OCD. The present study also included ten age-, sex-, and IQ-matched controls. The P300 and mismatch negativity (MMN components during an auditory oddball task at baseline for both groups and after 1 year of treatment for patients with OCD were measured.Results: Compared with controls, P300 amplitude was attenuated in the OCD group at Cz and C4 at baseline. Pharmacotherapy and psychotherapy treatment for 1 year reduced OCD symptomology. P300 amplitude after 1 year of treatment was significantly increased, indicating normalization compared with baseline at Fz, Cz, C3, and C4. We found no differences in P300 latency, MMN amplitude, or MMN latency between baseline and after one year of treatment.Conclusion: ERPs may be a useful tool for evaluating pharmacological and cognitive behavioral therapy in adult patients with OCD. Keywords: obsessive-compulsive disorder, event-related potentials, P300, mismatch negativity, improvement

  5. Individual, physical and psychological risk factors for neck pain in Australian office workers: a 1-year longitudinal study.

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    Hush, Julia M; Michaleff, Zoe; Maher, Christopher G; Refshauge, Kathryn

    2009-10-01

    Neck pain is more prevalent in office workers than in the general community. To date, findings from prospective studies that investigated causal relationships between putative risk factors and the onset of neck pain in this population have been limited by high loss to follow-up. The aim of this research was to prospectively evaluate a range of risk factors for neck pain in office workers, using validated and reliable objective measures as well as attain an estimate of 1-year incidence. We assembled a cohort of 53 office workers without neck pain and measured individual, physical, workplace and psychological factors at baseline. We followed participants for 1 year to measure the incidence of neck pain. We achieved 100% participant follow-up. Cox regression analysis was applied to examine the relationship between the putative risk factors and the cumulative incidence of neck pain. The 1-year incidence proportion of neck pain in Australian office workers was estimated in this study to be 0.49 (95% CI 0.36-0.62). Predictors of neck pain with moderate to large effect sizes were female gender (HR: 3.07; 95% CI: 1.18-7.99) and high psychological stress (HR: 1.64; 95% CI: 0.66-4.07). Protective factors included increased mobility of the cervical spine (HR: 0.44; 95% CI: 0.19-1.05) and frequent exercise (HR: 0.64; 95% CI: 0.27-1.51). These results reveal that neck pain is common in Australian office workers and that there are risk factors that are potentially modifiable.

  6. Developing Extension Professionals to Develop Extension Programs: A Case Study for the Changing Face of Extension

    Directory of Open Access Journals (Sweden)

    Scott R. Cummings

    2015-06-01

    Full Text Available Development of Cooperative Extension programs depends upon the skills and abilities of competent Extension professionals. The most effective manner of building program development competencies in these Extension professionals is through professional development. A wide variety of competencies are necessary for Extension professionals to develop programs, including strong interpersonal skills. Differences exist between the professional development efforts of Extension institutions and are highlighted herein. Major challenges to delivery of professional development include time and budget, but these can be overcome through planning and innovation and use of online or hybrid methods. Professional development for program development is essential to furthering Extension’s mission, especially during times of rapid change.

  7. Acupuncture and occlusal splint therapy in the treatment of craniomandibular disorders. II. A 1-year follow-up study.

    Science.gov (United States)

    List, T; Helkimo, M

    1992-12-01

    Eighty patients, of whom 22 were men and 58 women, participated in a 1-year follow-up study. All participants in the study showed signs and symptoms of craniomandibular disorders (CMD) and had had pain for more than 6 months at treatment start. The patients were randomly assigned to either acupuncture or occlusal splint therapy. Those patients who did not respond to either of the treatment modes were offered various additional therapies. The result showed that 57% of the patients who received acupuncture and 68% of the patients treated with occlusal splint therapy benefited subjectively (p < 0.01) and clinically (p < 0.001) from the treatment over a 12-month period. No statistically significant difference was found between the two groups as to the assessment variables. Those patients who received various additional therapies after acupuncture and/or occlusal splint therapy responded favorably to additional treatment in only a few instances. The study showed that acupuncture gave positive results similar to those of occlusal splint therapy in patients with primarily myogenic CMD symptoms over a 1-year follow-up period.

  8. Time to First Shunt Failure in Pediatric Patients over 1 Year Old: A 10-Year Retrospective Study.

    Science.gov (United States)

    Shannon, Chevis N; Carr, Kevin R; Tomycz, Luke; Wellons, John C; Tulipan, Noel

    2013-01-01

    Studies comparing alternatives to ventriculoperitoneal (VP) shunting for treatment of hydrocephalus have often relied upon data from an earlier era that may not be representative of contemporary shunt survival outcomes. We sought to determine the shunt survival rate of our cohort and compare our results to previously published shunt survival and endoscopic third ventriculostomy (ETV) success rates. We identified 95 patients between 1 and 18 years of age, who underwent initial VP shunt placement between January 2001 and December 2010. Our study shows a shunt survival rate of 85% at 6 months and 79% at 2 years, for initial shunts in pediatric patients over 1 year of age in this cohort. The overall infection rate was 3%. This compares favorably with published success rates of ETV at similar time points as well as with the rate of infection. This suggests that ventricular shunting remains a viable alternative to ETV in the older child.

  9. 1-year follow-up after radiofrequency tonsillotomy and laser tonsillotomy in children: a prospective, double-blind, clinical study.

    Science.gov (United States)

    Stelter, Klaus; Ihrler, Stephan; Siedek, Vanessa; Patscheider, Martin; Braun, Thomas; Ledderose, Georg

    2012-02-01

    In the last decade, tonsillotomy has come into vogue again, whereas the number of tonsillectomies is decreasing rapidly. In a previous study, the tonsillotomy with laser or radiofrequency therapy proved as a safe and effective procedure with minimal pain and hemorrhage. This follow-up study determines which method is more effective with respect to long-term outcome, recurrence of tonsillar hyperplasia and recurrence of tonsillitis. A prospective, randomised, double-blinded controlled clinical study was conducted at the Department of Otorhinolaryngology of the Ludwig-Maximilians-University, Munich, Germany. Twenty-six children with tonsillar hypertrophy were included. Tonsillotomy was performed on one side with monopolar radiofrequency and on the other side with a carbon dioxide laser. Exactly 1 year after the procedure, all 26 patients were documented by digital photography to define a possible recurrence of tonsillar hyperplasia. All parents were asked for occurring tonsillitis and fulfilled the Glasgow Children's Benefit Inventory (GCBI) for health-related quality of life after surgical procedures. In seven children, a slightly visible recurrence of the tonsillar hyperplasia occurred, without any symptoms or correlation to the different methods and sides. One child with recurrent tonsillitis and hyperplasia had to be tonsillectomized 8 months after the initial tonsillotomy procedure. The specimen showed open crypts with bacterial infection in the deep. The GCBI resulted in highly significant benefits of the surgery in all categories and subcategories. In conclusion, both methods, the laser tonsillotomy and the radiofrequency method, were equal concerning the effectiveness and safety after 1 year. Further investigations have to aim at the long-term outcome after tonsillotomy in patients with recurrent infections.

  10. Randomised study for the 1-year crestal bone maintenance around modified diameter implants with different loading protocols: a radiographic evaluation.

    Science.gov (United States)

    Danza, Matteo; Tortora, Pietro; Quaranta, Alessandro; Perrotti, Vittoria; Vozza, Iole; Piattelli, Adriano

    2010-08-01

    This study evaluated by standardised digitised periapical radiography the crestal bone maintenance around modified diameter internal hex implants with variable thread design and narrow neck loaded with different procedures. Forty implants were placed in 25 patients. Twenty implants were conventionally loaded, 20 ones immediately loaded. Radiographs were taken with a customised bite record and processed with software. Measurements of bone from the fixture-abutment junction to mesial and distal marginal bone levels were made. Student's t test statistical analysis was adopted. Baseline data were variable; at 1-year follow-up, there were no significant differences for marginal bone loss between immediately and conventionally loaded maxillary implants (p = 0.1031), whilst there were slight significant differences between immediately and conventionally loaded implants in the mandible (p = 0.0141). Crestal bone maintenance around conventionally and immediately loaded modified diameter implants was similar, with slight significant differences in mandible where a lower marginal bone loss was observed.

  11. Young male soccer players exhibit additional bone mineral acquisition during the peripubertal period: 1-year longitudinal study.

    Science.gov (United States)

    Zouch, Mohamed; Vico, Laurence; Frere, Delphine; Tabka, Zouhair; Alexandre, Christian

    2014-01-01

    The aim of this study was to determine whether soccer could have different bone benefits in prepubescent and pubescent boys. We investigated 76 boys aged 10 to 13 years during a 1-year study. All boys were prepubescent at the beginning of the study (T0); pubescent status was determined by a complete 24-h urine hormonal assay of FSH-LH, with LH ≤ 0.31 IU/24 h and FSH ≤ 2.19 IU/24 h corresponding to prepubescent Tanner stage I and with 0.31 soccer players (F1) and 13 controls (C1)), and 41 boys had entered puberty (26 soccer players (F2) and 15 controls (C2)). Soccer players completed 2 to 5 h of training plus one competition game per week during the school year, and controls only had physical education at school. Bone mineral content (BMC) was measured at T0 and T1 by DPX in the lumbar spine, total hip, and whole body (WB) for a comparison between soccer players and controls. At T0, no BMC difference was found between F1 and C1, but BMC was higher in F2 than C2 in WB and weight-bearing sites. At T1, BMC was higher in WB and weight-bearing sites in both F1 and F2 compared to their respective controls. Between T0 and T1, soccer induced a BMC gain at weight-bearing sites in both F1 and F2 compared to C1 and C2, respectively. The soccer-related bone gain was greater in WB and weight-bearing (the lumbar spine, total hip, and supporting leg) and non-weight-bearing bones (dominant arm and nondominant arm) in boys who became pubescent than in boys who remained prepubescent. In conclusion, 1-year study in young male soccer players demonstrates that the process of bone accretion at the very early phase of puberty is more intensely stimulated by the combination of physical exercise and sexual impregnation than by one of these factors alone.

  12. Time to relapse and remission of bipolar disorder: findings from a 1-year prospective study in Thailand

    Directory of Open Access Journals (Sweden)

    Leelahanaj T

    2013-08-01

    Full Text Available Thawatchai Leelahanaj,1 Ronnachai Kongsakon,2 Somrak Choovanichvong,3 Sookjaroen Tangwongchai,4 Suchat Paholpak,5 Thoranin Kongsuk,6 Manit Srisurapanont7 For the Thai Bipolar Registry Study Group 1Department of Psychiatry and Neurology, Phramongkutklao Hospital, Bangkok, Thailand; 2Department of Psychiatry, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand; 3Srithanya Hospital, Nonthaburi, Thailand; 4Department of Psychiatry, Chulalongkorn University, Bangkok, Thailand; 5Department of Psychiatry, Khon Kaen University, Khon Kaen, Thailand; 6Prasrimahabhodi Psychiatric Hospital, Ubon Ratchathani, Thailand; 7Department of Psychiatry, Chiang Mai University, Chiang Mai, Thailand Background and methods: This study aimed to determine time to relapse and remission of mood episodes in Thai patients with bipolar disorder (BD. The Thai Bipolar Disorder Registry was a multicenter, prospective, naturalistic, observational study conducted in Thailand. Participants were adult inpatients or outpatients with Diagnostic and Statistical Manual of Mental Disorders bipolar disorder. The diagnosis of bipolar disorder, current psychiatric comorbidity, mood relapse, and mood remission were determined by using the Mini International Neuropsychiatric Interview. Relapse and remission were assessed every 2 months. Results: Of 424 BD participants, 404 (95.3% were BD I, and 258 (60.8% were female. At entry, 260 (61.3% had recovered, and 49 (11.6% were recovering. During 1-year follow-up (381.7 person-years, 92 participants (21.7% had 119 relapses or 0.31 (95% confidence interval 0.25–0.35 episodes per person-year. Among 119 relapses, 58 (48.7%, 39 (32.7%, and 21 (17.6% of them were depressive, hypomanic, and manic episodes, respectively. Using the Kaplan–Meier method, we found that 25% of the participants relapsed in 361 days. Of the 400 participants who reached remission, 113 (28.2% had mood relapses. Of 173 mood events accountable for remission analysis, the

  13. Predictors of Poststroke Health-Related Quality of Life in Nigerian Stroke Survivors: A 1-Year Follow-Up Study

    Directory of Open Access Journals (Sweden)

    Ashiru Mohammad Hamza

    2014-01-01

    Full Text Available This study aims to identify the predictors in the different aspects of the health-related quality of life (HRQoL and to measure the changes of functional status over time in a cohort of Nigerian stroke survivors. A prospective observational study was conducted in three hospitals of Kano state of Nigeria where stroke survivors receive rehabilitation. The linguistic-validated Hausa versions of the stroke impact scale 3.0, modified Rankin scale, Barthel index and Beck depression inventory scales were used. Paired samples t-test was used to calculate the amount of changes that occur over time and the forward stepwise linear regression model was used to identify the predictors. A total of 233 stroke survivors were surveyed at 6 months, and 93% (217/233 were followed at 1 year after stroke. Functional disabilities were significantly reduced during the recovery phase. Motor impairment, disability, and level of depression were independent predictors of HRQoL in the multivariate regression analysis. The involvement of family members as caregivers is the key factor for those survivors with improved functional status. Thus, to enhance the quality of poststroke life, it is proposed that a holistic stroke rehabilitation service and an active involvement of family members are established at every possible level.

  14. Effect of monochloramine treatment on colonization of a hospital water distribution system by Legionella spp.: a 1 year experience study.

    Science.gov (United States)

    Mancini, Benedetta; Scurti, Maria; Dormi, Ada; Grottola, Antonella; Zanotti, Andrea; Cristino, Sandra

    2015-04-01

    Contamination of hot water distribution systems by Legionella represents a great challenge due to difficulties associated with inactivating microorganisms, preserving the water characteristics. The aim of this study was to examine over the course of 1 year in 11 fixed sites, the impact of monochloramine disinfection on Legionella, heterotrophic bacteria (36 °C), Pseudomonas aeruginosa contamination, and chemical parameters of a plumbing system in an Italian hospital. Three days after installation (T0), in the presence of monochloramine concentration between 1.5 and 2 mg/L, 10/11 sites (91%) were contaminated by L. pneumophila serogroups 3 and 10. After these results, the disinfectant dosage was increased to between 6 and 10 mg/L, reducing the level of Legionella by three logarithmic unit by 2 months postinstallation (T2) until 6 months later (T3). One year later (T4), there was a significant reduction (p = 0.0002) at 8/11 (73%) sites. Our data showed also a significant reduction of heterotrophic bacteria (36 °C) in 6/11 (55%) sites at T4 (p = 0.0004), by contrast the contamination of P. aeruginosa found at T0 in two sites persisted up until T4. The results of the present study show that monochloramine is a promising disinfectant that can prevent Legionella contamination of hospital water supplies.

  15. Sing Your Lungs Out—a community singing group for chronic obstructive pulmonary disease: a 1-year pilot study

    Science.gov (United States)

    McNaughton, Amanda; Weatherall, Mark; Williams, Mathew; McNaughton, Harry; Aldington, Sarah; Williams, Gayle; Beasley, Richard

    2017-01-01

    Objective Singing group participation may benefit patients with chronic obstructive pulmonary disease (COPD). Previous studies are limited by small numbers of participants and short duration of generally hospital-based singing group intervention. This study examines the feasibility of long-term participation in a community singing group for patients with COPD who had completed pulmonary rehabilitation (PR). Methods This was a feasibility cohort study. Patients with COPD who had completed PR and were enrolled in a weekly community exercise group were recruited to a new community-based singing group which met weekly for over 1 year. Measurements at baseline, 4 months and 1 year comprised comprehensive pulmonary function tests including lung volumes, 6 min walk test (6MWT), Clinical COPD Questionnaire (CCQ), Hospital Anxiety and Depression Scale (HADS) and hospital admission days for acute exacerbation of COPD (AECOPD) for 1 year before and after the first singing group session. Findings There were 28 participants with chronic lung disease recruited from 140 people approached. Five withdrew in the first month. 21 participants meeting Global Initiative for Chronic Obstructive Lung Disease criteria for COPD completed 4-month and 18 completed 1-year assessments. The mean attendance was 85%. For the prespecified primary outcome measure, total HADS score, difference between baseline and 12 months was −0.9, 95% CI −3.0 to 1.2, p=0.37. Of the secondary measures, a significant reduction was observed for HADS anxiety score after 1 year of −0.9 (95% CI −1.8 to −0.1) points, p=0.038 and an increase in the 6MWT at 1 year, of 65 (95% CI 35 to 99) m compared with baseline pexercise group and provide evidence of improved exercise capacity and a reduction in anxiety. Trial registration number ACTRN12615000736549; Results. PMID:28119393

  16. Optimising iron chelation therapy with deferasirox for non-transfusion-dependent thalassaemia patients: 1-year results from the THETIS study.

    Science.gov (United States)

    Taher, Ali T; Cappellini, M Domenica; Aydinok, Yesim; Porter, John B; Karakas, Zeynep; Viprakasit, Vip; Siritanaratkul, Noppadol; Kattamis, Antonis; Wang, Candace; Zhu, Zewen; Joaquin, Victor; Uwamahoro, Marie José; Lai, Yong-Rong

    2016-03-01

    Efficacy and safety of iron chelation therapy with deferasirox in iron-overloaded non-transfusion-dependent thalassaemia (NTDT) patients were established in the THALASSA study. THETIS, an open-label, single-arm, multicentre, Phase IV study, added to this evidence by investigating earlier dose escalation by baseline liver iron concentration (LIC) (week 4: escalation according to baseline LIC; week 24: adjustment according to LIC response, maximum 30mg/kg/day). The primary efficacy endpoint was absolute change in LIC from baseline to week 52. 134 iron-overloaded non-transfusion-dependent anaemia patients were enrolled and received deferasirox starting at 10mg/kg/day. Mean actual dose±SD over 1year was 14.70±5.48mg/kg/day. At week 52, mean LIC±SD decreased significantly from 15.13±10.72mg Fe/g dw at baseline to 8.46±6.25mg Fe/g dw (absolute change from baseline, -6.68±7.02mg Fe/g dw [95% CI: -7.91, -5.45]; P<0.0001). Most common drug-related adverse events were gastrointestinal: abdominal discomfort, diarrhoea and nausea (n=6 each). There was one death (pneumonia, not considered drug related). With significant and clinically relevant reductions in iron burden alongside a safety profile similar to that in THALASSA, these data support earlier escalation with higher deferasirox doses in iron-overloaded non-transfusion-dependent anaemia patients.

  17. Efficacy and safety of tiotropium Respimat® SMI in COPD in two 1-year randomized studies

    Directory of Open Access Journals (Sweden)

    Eric Bateman

    2010-06-01

    Full Text Available Eric Bateman1, Dave Singh2, David Smith3, Bernd Disse4, Lesley Towse5, Dan Massey5, Jon Blatchford5, Demetri Pavia5, Rick Hodder61Division of Pulmonology, Department of Medicine, University of Cape Town, Cape Town, South Africa; 2University Hospital of South Manchester Foundation Trust, University of Manchester, Manchester, UK; 3North Bristol Lung Centre, Southmead Hospital, Bristol, UK; 4Boehringer Ingelheim, GmbH, Ingelheim, Germany; 5Boehringer Ingelheim, Ltd., Bracknell, Berkshire, UK; 6Divisions of Pulmonary and Critical Care Medicine, University of Ottawa, Ottawa, Ontario, CanadaAbstract: Two 1-year studies evaluated the long-term efficacy and safety of tiotropium 5 or 10 μg versus placebo, inhaled via the Respimat® Soft MistTM Inhaler (SMI. The two studies were combined and had 4 co-primary endpoints (trough FEV1 response, Mahler Transition Dyspnea Index [TDI] and St George’s Respiratory Questionnaire scores all at week 48, and COPD exacerbations per patient-year. A total of 1990 patients with COPD participated (mean FEV1: 1.09 L. The mean trough FEV1 response of tiotropium 5 or 10 μg relative to placebo was 127 or 150 mL, respectively (both P < 0.0001. The COPD exacerbation rate was significantly lower with tiotropium 5 μg (RR = 0.78; P = 0.002 and tiotropium 10 μg (RR = 0.73; P = 0.0008; the health-related quality of life and Mahler TDI co-primary endpoints were significantly improved with both doses (both P < 0.0001. Adverse events were generally balanced except anticholinergic class effects, which were more frequent with active treatment. Fatal events occurred in 2.4% (5 μg, 2.7% (10 μg, and 1.6% (placebo of patients; these differences were not significant. Tiotropium Respimat® SMI 5 μg demonstrated sustained improvements in patients with COPD relative to placebo and similar to the 10 μg dose but with a lower frequency of anticholinergic adverse events.Keywords: COPD, exacerbations, FEV1, quality of life, Respimat

  18. Differential effects of mental and physical health and coping style on work ability: a 1-year follow-up study among aging workers

    NARCIS (Netherlands)

    Vijfeijke, H. van de; Leijten, F.R.; Ybema, J.F.; Heuvel, S.G. van den; Robroek, S.J.; Beek, A.J. van der; Burdorf, A.; Taris, T.W.

    2013-01-01

    OBJECTIVE: This study examines whether mental and physical health relate differently to work ability and whether these associations vary with coping style. METHODS: A 1-year longitudinal study was conducted among 8842 employees aged 45 to 64 years from the Study on Transitions in Employment, Ability

  19. Protocol for the dano-run study: A 1-year observational follow-up study on running related injuries in 1000 novice runners

    DEFF Research Database (Denmark)

    Nielsen, R.O.; Ramskov, Daniel; Buist, Ida

    2011-01-01

    their GPS watch at each training session and upload data to an internet based database. All participants are followed for 1 year. Assessment of risk factors Running volume measured as absolute number of kilometres and the graduation in kilometres pr. week over a period of 3 weeks. Main outcome measurement...... weekly training graduations. Conclusion This study may be the first study to adequately measure running patterns reliably in a large sample. The exposure is quantified by GPS, which is not affected by subject recall and is therefore a clear methodological improvement compared to previous studies...

  20. Study on Extension Strategy-Tactics-Planning

    Institute of Scientific and Technical Information of China (English)

    YangChunyan; ZhangYongjun; ZhuDongmei

    2004-01-01

    Extension strategy-tactics-planning (ESTP), based upon the science of Extenics, is established for the purpose of solving contradictory problems. In this paper, the fundamental thoughts, theories and methods of ESTP are introduced concisely. The highlights of ESTP are that the techniques, used in the case of tackling such problems as how to generate the ideas of strategy-tactics-planning, how to completely analyze the resources, how to exploit extension resources, how to transfer the incompatible into the compati-ble, and how to transfer the opposite into the co-existent, are developed in a formalized way. And regarding the practices of ESTP, the applications of ESTP in resource integration, project, market development, and the prevention and handling crises are presented.

  1. A 1-year multicenter randomized double-blind comparison of repaglinide and glyburide for the treatment of type 2 diabetes. Dutch and German Repaglinide Study Group

    NARCIS (Netherlands)

    Wolffenbuttel, B H; Landgraf, R

    1999-01-01

    OBJECTIVE: Repaglinide is a newly developed oral blood glucose-lowering agent that exerts its effect by stimulating insulin secretion. This multicenter study was designed to compare the efficacy and safety of this drug with glyburide in a 1-year randomized double-blind study of outpatients with type

  2. Maxillary Overdentures Supported by Anteriorly or Posteriorly Placed Implants Opposed by a Natural Dentition in the Mandible : A 1-Year Prospective Case Series Study

    NARCIS (Netherlands)

    Slot, Jan; Raghoebar, Gerry M.; Vissink, Arjan; Meijer, Henny J. A.

    2014-01-01

    Background: For maxillary overdenture therapy, treatment guidelines are missing. There is a need for longitudinal studies. Purpose: The purpose of this 1-year prospective case series study was to assess the treatment outcome of maxillary overdentures supported by six dental implants opposed by natur

  3. Relevance of the 1-year dog study in assessing human health risks for registration of pesticides. An update to include pesticides registered in Japan.

    Science.gov (United States)

    Kobel, Werner; Fegert, Ivana; Billington, Richard; Lewis, Richard; Bentley, Karin; Langrand-Lerche, Carole; Botham, Phil; Sato, Masako; Debruyne, Eric; Strupp, Christian; van Ravenzwaay, Bennard

    2014-11-01

    Over 400 active pesticides are registered in Japan (FAMIC 2013). The results of dog toxicity studies (usually, the 1-year study) were used by the Japanese regulatory authorities to establish the acceptable daily intake (ADI) for 45 pesticide active ingredients (about 9%). A retrospective review of ADIs established in Japan with dog studies as pivotal data for their derivation was performed: the ADIs were reassessed under the assumption that the 1-year dog study would not be available and an alternate ADI was derived based on the remaining toxicology database. In 35 of the 45 cases (77.8%) the ADI resulting from the absence of the 1-year dog study was no greater than twice the Japanese ADI, a difference considered not to be of biological significance. In 6 cases (13%) the resulting ADI was 2-5 times higher, which is considered of questionable biological relevance. On further evaluation of the database, three of these six cases were assessed as to clarify that there is no clear difference and for the other three additional studies to clarify that uncertain findings would have been required. In 3 of the 45 cases (7%) there may be a real difference within the ADI ratio of 2-5. Only in 1 case (2.2%) ADI was five times higher than that has been set. Accordingly, the absence of a 1-year dog study does not appear to influence the ADI derivation in a relevant manner in more than 98% of cases. For the four compounds with a real difference in ADI, consumer exposure would still be well below the alternative ADI. Therefore, a strong case can be made that the standard mandatory requirement to conduct a 1-year dog study, in addition to the 3-month study, is not justified and of no additional value in protecting human health. In addition, a substantial reduction in test animals could be achieved.

  4. Rapid Naming in Relation to Reading and Writing in Korean (Hangul), Chinese (Hanja) and English among Korean Children: A 1-Year Longitudinal Study

    Science.gov (United States)

    Cho, Jeung-Ryeul; Chiu, Ming Ming

    2015-01-01

    The relation of rapid automatised naming (RAN) to word recognition may depend on the phonological regularity of the orthography. This study examined differential contributions of RAN to reading and writing in Korean alphabetic Hangul, logographic Hanja (Chinese) and English as a second language among 73 fifth graders in Korea across 1?year. RAN…

  5. Foot pronation is not associated with increased injury risk in novice runners wearing a neutral shoe : a 1-year prospective cohort study

    NARCIS (Netherlands)

    Nielsen, Rasmus Oestergaard; Buist, Ida; Parner, Erik Thorlund; Nohr, Ellen Aagaard; Sorensen, Henrik; Lind, Martin; Rasmussen, Sten

    2014-01-01

    Objective To investigate if running distance to first running-related injury varies between foot postures in novice runners wearing neutral shoes. Design A 1-year epidemiological observational prospective cohort study. Setting Denmark. Participants A total of 927 novice runners equivalent to 1854 fe

  6. Prolonged fatigue is associated with sickness absence in men but not in women : prospective study with 1-year follow-up of white-collar employees

    NARCIS (Netherlands)

    Roelen, Corne A. M.; van Rhenen, Willem; Groothoff, Johan W.; van der Klink, Jac J. L.; Bultmann, Ute

    2014-01-01

    Prolonged fatigue adversely affects an individual's performance and functioning. The present study investigated the prospective associations between prolonged fatigue and sickness absence (SA) during 1-year follow-up. At baseline, a convenience sample of white-collar employees received the 20-item C

  7. Elbow and wrist/hand symptoms among 6,943 computer operators: a 1-year follow-up study (the NUDATA study)

    DEFF Research Database (Denmark)

    Lassen, C. F.; Mikkelsen, S.; Kryger, Ann Isabel

    2004-01-01

    BACKGROUND: The aim of this study was to examine relations between computer work aspects and elbow and wrist/hand pain conditions and disorders. METHODS: In a 1-year follow-up study among 6,943 technical assistants and machine technicians self-reported active mouse and keyboard time, ergonomic...... exposures and associations with elbow and wrist/hand pain were determined. Standardized clinical examinations were performed among symptomatic participants at baseline and at follow-up. RESULTS: For continuous duration of mouse time adjusted linear effects were statistically significant for all investigated...... pain conditions. For continuous duration of keyboard time the corresponding effects were statistically significant for wrist/hand pain conditions except incident 'severe' wrist/hand pain. There were no threshold effects above 0 hr per week (hr/w) of mouse exposure in association with pain conditions...

  8. A study on adverse drug reactions to non-ionic contrast medium in an Indian population: a 1-year experience

    Directory of Open Access Journals (Sweden)

    Subhrojyoti Bhowmick

    2014-12-01

    Conclusions: This pilot study reveals that adverse reactions to NICM are rare and severe reactions are less common among the patients of Indian origin. However, a larger multicentric study across the country should be carried out to understand the safety profile of these CM better among the Indian population. [Int J Basic Clin Pharmacol 2014; 3(6.000: 1066-1071

  9. Single Restorations in the Resorbed Posterior Mandible Supported by 6-mm Implants : A 1-Year Prospective Case Series Study

    NARCIS (Netherlands)

    Gulje, Felix L.; Raghoebar, Gerry M.; Vissink, Arjan; Meijer, Henny J. A.

    2015-01-01

    PurposeThe aim of this prospective case series study was to assess the clinical performance of single restorations in the posterior mandible supported by 6-mm implants. Materials and MethodsTwenty-one consecutive patients with one or more missing premolars or molars in the posterior mandible and wit

  10. Outdoor Operational Stability of Indium-Free Flexible Polymer Solar Modules Over 1 Year Studied in India, Holland, and Denmark

    DEFF Research Database (Denmark)

    Angmo, Dechan; Sommeling, Paul M.; Gupta, Ritu;

    2014-01-01

    -cost plastic barrier material with the use of a UV curing adhesive. The impact of differences in the climatic conditions on the performance of the modules is highlighted and the performance of the modules under storage conditions in parallel with the outdoor study is investigated. While all Gen-I modules...

  11. Socioeconomic status and duration and pattern of sickness absence. A 1-year follow-up study of 2331 hospital employees

    DEFF Research Database (Denmark)

    Kristensen, Trine Rønde; Jensen, Signe Marie; Kreiner, Svend;

    2010-01-01

    prospective cohort study of 2331 hospital employees. Baseline information include job title, work unit, perceived general health, work factors and personal factors recorded from hospital administrative files or by questionnaire (response rate 84%). Sickness absence during follow-up was divided into short (1...

  12. Changes in lifestyle habits after counselling by nurse practitioners : 1-year results of the Groningen Overweight and Lifestyle study

    NARCIS (Netherlands)

    ter Bogt, Nancy C. W.; Milder, Ivon E. J.; Bemelmans, Wanda J. E.; Beltman, Frank W.; Broer, Jan; Smit, Andries J.; van der Meer, Klaas

    2011-01-01

    Objectives: The Groningen Overweight and Lifestyle (GOAL) study primarily aims at preventing weight gain by nurse practitioners (NP) guided by a standardized computerized software program. Since favourable changes in physical activity (PA) and diet may improve health independently of weight (loss),

  13. Clinical evaluation of unselected cardiac arrest survivors in a tertiary center over a 1-year period (the LAZARUZ study)

    DEFF Research Database (Denmark)

    Marstrand, Peter; Corell, Pernille; Henriksen, Finn Lund;

    2016-01-01

    and supplemental electrocardiograms were evaluated for additional diagnostic information. RESULTS: 43 cardiac arrest survivors were included, 34 (79%) were male and the average age was 48years (range 23-64, SD 13.0). The most common etiologies identified in cardiac arrest survivors were ischemic heart disease (33...... of the electrocardiogram. We suggest that these ECG derived clues be investigated in future studies including genetic test results and data from relatives....

  14. Clinical assessment of prognostic factors for long-term pain and handicap after whiplash injury: a 1-year prospective study

    DEFF Research Database (Denmark)

    Kasch, H; Qerama, E; Kongsted, Alice

    2008-01-01

    of non-painful complaints and active neck mobility [active cervical range of motion (CROM)]. All 458 high-risk patients and 230 low-risk patients received mailed questionnaires after 3, 6 and 12 months. Two examiners examined all high-risk patients (n = 458) and 41 consecutive low-risk patients at median......BACKGROUND AND PURPOSE: Physical mechanisms are the possible factors involved in the development and maintenance of long-term handicaps after acute whiplash injury. This study prospectively examined the role of active neck mobility, cervical and extra-cervical pains, as well as non...

  15. Morbid obese adults increased their sense of coherence 1 year after a patient education course: a longitudinal study

    Directory of Open Access Journals (Sweden)

    Fagermoen MS

    2015-03-01

    Full Text Available May Solveig Fagermoen,1 Glenys Hamilton,2 Anners Lerdal1,3 1Department of Nursing Science, Institute of Health and Society, University of Oslo, Oslo, Norway; 2GAH Consulting, Boston, MA, USA; 3Department of Research, Lovisenberg Diakonale Hospital, Oslo, Norway Background: Personal factors are key elements to understand peoples' health behavior. Studies of such factors are important to develop targeted interventions to improve health. The main purpose of this study is to explore sense of coherence (SOC in a sample of persons with morbid obesity before and after attending a patient education course and to explore the association between SOC and sociodemographic and other personal factors. Methods: In this longitudinal purposely sampled study, the participants completed questionnaires on the first day of the course and 12 months after course completion. Sixty-eight participants had valid scores on the selected variables at follow-up: SOC, self-esteem, and self-efficacy. Relationships were assessed with correlation analyses and paired and independent samples t-tests and predictors with linear regression analyses. Results: From baseline to follow-up, the total SOC score and the subdimension scores comprehensibility, manageability, and meaningfulness all increased significantly. At both time points, the SOC scores were low compared to the general population but similar to scores in other chronically ill. At baseline, a multivariate analysis showed that older age, having paid work, and higher self-esteem were directly related to higher total SOC score after controlling for other sociodemographic factors and the participants' level of self-efficacy. Multivariate analyses of the relationship between baseline predictors of SOC at 12-month follow-up, controlling for baseline SOC scores or sociodemographic or personal factors, revealed that none of these variables independently predicted SOC scores at follow-up. Conclusion: The total SOC score and its

  16. Bone mineral density of the proximal femur after hip resurfacing arthroplasty: 1-year follow-up study

    Directory of Open Access Journals (Sweden)

    Anttila Esa

    2011-05-01

    Full Text Available Abstract Background Hip resurfacing arthroplasty (HRA is considered a bone-preserving procedure and may eliminate proximal femoral stress shielding and osteolysis. However, in addition to implant-related stress-shielding factors, various patient-related factors may also have an effect on bone mineral density (BMD of the proximal femur in patients with HRA. Thus, we studied the effects of stem-neck angle, demographic variables, and physical functioning on the BMD of the proximal femur in a one-year follow-up. Methods Thirty three patients (9 females and 24 males with a mean (SD age of 55 (9 years were included in the study. BMD was measured two days and 3, 6, and 12 months postoperatively and 10 regions of interest (ROI were used. Stem-neck angle was analyzed from anteroposterior radiographs. Results Three months postoperatively, BMD decreased in six out of 10 regions of interest (ROI on the side operated on and in one ROI on the control side (p Conclusions After an early drop, the BMD of the upper femur was restored and even exceeded the preoperative level at one year follow-up. From a clinical standpoint, the changes in BMD in these HRA patients could not be explained by stem-neck angle or patient related factors.

  17. Psychological and Work Stress Assessment of Patients following Angioplasty or Heart Surgery: Results of 1-year Follow-up Study.

    Science.gov (United States)

    Fiabane, Elena; Giorgi, Ines; Candura, Stefano M; Argentero, Piergiorgio

    2015-12-01

    The aim of this study was to explore changes in subjective psychological health and perceived work stress among patients who returned to work (RTW) after a multidisciplinary cardiac rehabilitation (CR) following cardiac interventions. A total of 108 patients were evaluated at the beginning of their CR, at 6 and 12 months after discharge. Self-report questionnaires were used to assess depression, anxiety, illness perception and work stress at each time stage. Results showed reports of depressive symptoms significantly decreased (p work stress after their RTW. Patients' psychological health and work stress need to be assessed during the CR and should be also carefully monitored after the RTW in order to identify patients' psychological and work-related barriers and facilitate a safe and successful work reintegration.

  18. Effects of phytoestrogen genistein on cytogenetic biomarkers in postmenopausal women: 1 year randomized, placebo-controlled study.

    Science.gov (United States)

    Atteritano, Marco; Pernice, Francesco; Mazzaferro, Susanna; Mantuano, Stefania; Frisina, Alessia; D'Anna, Rosario; Cannata, Maria Letizia; Bitto, Alessandra; Squadrito, Francesco; Frisina, Nicola; Buemi, Michele

    2008-07-28

    To evaluate in a twelve-month, randomized placebo-controlled study whether pure administration of phytoestrogen genistein (54 mg/day) might reduce cytogenetic biomarkers in peripheral lymphocytes of postmenopausal women. A total of 57 postmenopausal women met the criteria and were randomly assigned to receive phytoestrogen genistein (n = 30) or placebo (n = 27). There was no significant difference in age, length of time since menopause or body mass index between the two groups. After one year, plasma genistein level was 0.14 +/- 0.01 micromol/L in the control group and 0.72 +/- 0.08 micromol/L in the genistein group (P < 0.0001). At baseline, sister chromatid exchange rate was 4.97 +/- 2.17 in the control group and 4.96 +/- 1.83 in the genistein group (P = 0.89). After one year, sister chromatid exchange rate was 4.96 +/- 2.16 in the control group and 3.98 +/- 1.14 in the genistein group (P < 0.05). High frequency cells count was 3% in the genistein group and 5% in the control group (P < 0.05) at the end of the study. Chromosomal aberration frequency was 5.55% in the control group at time 0 and 5.75% in the genistein group; after one year, the figures were 5.86% in the control group and 4.5% in the genistein group (P < 0.05). After one year, there was a negative relationship between sister chromatid exchange rate and plasma levels (r = - 0.43; P < 0.05) in the genistein group. Phytoestrogen genistein has been shown in postmenopausal women to be effective in the reduction of cytogenetic biomarkers. The protective effect on genomic damage appears to be a particularly promising tool in reducing the risk of cancer.

  19. FDG PET during radiochemotherapy is predictive of outcome at 1 year in non-small-cell lung cancer patients: a prospective multicentre study (RTEP2)

    Energy Technology Data Exchange (ETDEWEB)

    Vera, Pierre; Edet-Sanson, Agathe; Modzelewski, Romain [Henri Becquerel Center and QuantIF - Litis EA-Equipe d' Accueil-4108 and Rouen University Hospital, Department of Nuclear Medicine, Henri Becquerel Cancer Center, Rouen (France); Mezzani-Saillard, Sandrine; Thureau, Sebastien; Dubray, Bernard [Henri Becquerel Center and QuantIF - Litis ' ' EA (Equipe d' Accueil) 4108' ' and Rouen University Hospital, Department of Radiation Oncology and Medical Physics, Henri Becquerel Cancer Center, Rouen (France); Menard, Jean-Francois [Rouen University Hospital and University of Rouen, Department of Biostatistics, Rouen (France); Meyer, Marc-Etienne [Amiens University Hospital, Department of Nuclear Medicine, Amiens (France); Jalali, Khadija [Amiens University Hospital, Department of Radiation Oncology, Amiens (France); Bardet, Stephane [Francois Baclesse Cancer Center, Department of Nuclear Medicine, Caen (France); Lerouge, Delphine [Francois Baclesse Cancer Center, Department of Radiation Oncology, Caen (France); Houzard, Claire [Hospices Civils de Lyon, Department of Nuclear Medicine, Lyon (France); Mornex, Francoise [Hospices Civils de Lyon, Department of Radiation Oncology, Lyon (France); Olivier, Pierre [Brabois University Hospital, Department of Nuclear Medicine, Nancy (France); Faure, Guillaume [Centre prive de Radiotherapie de Metz, Department of Radiation Oncology, Metz (France); Rousseau, Caroline [Renee Gauducheau Cancer Center, Department of Nuclear Medicine, Nantes (France); Mahe, Marc-Andre [Institut de Cancerologie-Rene Gauducheau, Department of Radiation Oncology, Nantes (France); Gomez, Philippe [Centre Frederic Joliot, Radiation Oncology, Rouen (France); Clinique Saint-Hilaire, Rouen (France); Brenot-Rossi, Isabelle [Institut Paoli Calmette, Department of Nuclear Medicine, Marseille (France); Salem, Naji [Institut Paoli Calmette, Department of Radiation Oncology, Marseille (France)

    2014-06-15

    To assess prospectively the prognostic value of FDG PET/CT during curative-intent radiotherapy (RT) with or without concomitant chemotherapy in patients with non-small-cell lung cancer (NSCLC). Patients with histological proof of invasive localized NSCLC and evaluable tumour, and who were candidates for curative-intent radiochemotherapy (RCT) or RT were preincluded after providing written informed consent. Definitive inclusion was conditional upon significant FDG uptake before RT (PET{sub 1}). All included patients had a FDG PET/CT scan during RT (PET{sub 2}, mean dose 43 Gy) and were evaluated by FDG PET/CT at 3 months and 1 year after RT. The main endpoint was death (from whatever cause) or tumour progression at 1 year. Of 77 patients preincluded, 52 were evaluable. Among the evaluable patients, 77 % received RT with induction chemotherapy and 73 % RT with concomitant chemotherapy. At 1 year, 40 patients (77 %) had died or had tumour progression. No statistically significant association was found between stage (IIIB vs. other), histology (squamous cell carcinoma vs. other), induction or concomitant chemotherapy, and death/tumour progression at 1 year. The SUV{sub max} in the PET{sub 2} scan was the single variable predictive of death or tumour progression at 1 year (odds ratio 1.97, 95 % CI 1.25 - 3.09, p = 0.003) in multivariate analysis. The area under the receiver operating characteristic curve was 0.85 (95 % CI 0.73 - 0.94, p < 10{sup -4}). A SUV{sub max} value of 5.3 in the PET{sub 2} scan yielded a sensitivity of 70 % and a specificity of 92 % for predicting tumour progression or death at 1 year. This prospective multicentre study demonstrated the prognostic value in terms of disease-free survival of SUV{sub max} assessed during the 5th week of curative-intent RT or RCT in NSCLC patients (NCT01261598; RTEP2 study). (orig.)

  20. Daily-Life Gait Quality as Predictor of Falls in Older People: A 1-Year Prospective Cohort Study

    Science.gov (United States)

    van Schooten, Kimberley S.; Pijnappels, Mirjam; Rispens, Sietse M.; Elders, Petra J. M.; Lips, Paul; Daffertshofer, Andreas; Beek, Peter J.; van Dieën, Jaap H.

    2016-01-01

    Falls can have devastating consequences for older people. We determined the relationship between the likelihood of fall incidents and daily-life behavior. We used wearable sensors to assess habitual physical activity and daily-life gait quality (in terms of e.g. stability, variability, smoothness and symmetry), and determined their predictive ability for time-to-first-and-second-falls. 319 older people wore a trunk accelerometer (Dynaport MoveMonitor, McRoberts) during one week. Participants further completed questionnaires and performed grip strength and trail making tests to identify risk factors for falls. Their prospective fall incidence was followed up for six to twelve months. We determined interrelations between commonly used gait characteristics to gain insight in their interpretation and determined their association with time-to-falls. For all data -including questionnaires and tests- we determined the corresponding principal components and studied their predictive ability for falls. We showed that gait characteristics of walking speed, stride length, stride frequency, intensity, variability, smoothness, symmetry and complexity were often moderately to highly correlated (r > 0.4). We further showed that these characteristics were predictive of falls. Principal components dominated by history of falls, alcohol consumption, gait quality and muscle strength proved predictive for time-to-fall. The cross-validated prediction models had adequate to high accuracy (time dependent AUC of 0.66–0.72 for time-to-first-fall and 0.69–0.76 for -second-fall). Daily-life gait quality obtained from a single accelerometer on the trunk is predictive for falls. These findings confirm that ambulant measurements of daily behavior contribute substantially to the identification of elderly at (high) risk of falling. PMID:27389583

  1. Daily-Life Gait Quality as Predictor of Falls in Older People: A 1-Year Prospective Cohort Study.

    Directory of Open Access Journals (Sweden)

    Kimberley S van Schooten

    Full Text Available Falls can have devastating consequences for older people. We determined the relationship between the likelihood of fall incidents and daily-life behavior. We used wearable sensors to assess habitual physical activity and daily-life gait quality (in terms of e.g. stability, variability, smoothness and symmetry, and determined their predictive ability for time-to-first-and-second-falls. 319 older people wore a trunk accelerometer (Dynaport MoveMonitor, McRoberts during one week. Participants further completed questionnaires and performed grip strength and trail making tests to identify risk factors for falls. Their prospective fall incidence was followed up for six to twelve months. We determined interrelations between commonly used gait characteristics to gain insight in their interpretation and determined their association with time-to-falls. For all data -including questionnaires and tests- we determined the corresponding principal components and studied their predictive ability for falls. We showed that gait characteristics of walking speed, stride length, stride frequency, intensity, variability, smoothness, symmetry and complexity were often moderately to highly correlated (r > 0.4. We further showed that these characteristics were predictive of falls. Principal components dominated by history of falls, alcohol consumption, gait quality and muscle strength proved predictive for time-to-fall. The cross-validated prediction models had adequate to high accuracy (time dependent AUC of 0.66-0.72 for time-to-first-fall and 0.69-0.76 for -second-fall. Daily-life gait quality obtained from a single accelerometer on the trunk is predictive for falls. These findings confirm that ambulant measurements of daily behavior contribute substantially to the identification of elderly at (high risk of falling.

  2. Short- and Long-Term Efficacy of Intensive Rehabilitation Treatment on Balance and Gait in Parkinsonian Patients: A Preliminary Study with a 1-Year Followup

    Directory of Open Access Journals (Sweden)

    Giuseppe Frazzitta

    2013-01-01

    Full Text Available Parkinson’s disease (PD is a neurodegenerative disease in which gait and balance disturbances are relevant symptoms that respond poorly to pharmacological treatment. The aim of this study was to investigate whether a 4-week inpatient multidisciplinary intensive rehabilitation treatment (MIRT is effective in improving balance and gait and whether improvements persist at a one-year followup. We studied 20 PD inpatients (stage 3 Hoehn-Yahr who underwent a MIRT. Outcome measures were UPDRS items for balance (30, falls (13, and walk (29, Berg Balance Scale, six-minute walking test, Timed Up and Go Test, and Comfortable-Fast gait speeds. Patients were evaluated at admission, at the end of the 4-week treatment, and at a 1-year followup. Pharmacological therapy was unchanged during MIRT and follow-up. All outcome measures improved significantly at the end of treatment. At 1-year follow-up control, UPDRS walk and Comfortable-Fast gait speeds still maintained better values with respect to admission (P=0.009, P=0.03, and P=0.02, resp., while the remaining scales did not differ significantly. Our results demonstrate that the MIRT was effective in improving balance and gait and that the improvement in gait performances was partially maintained also after 1 year.

  3. Free thyroxine levels are associated with cognitive changes in individuals with a first episode of psychosis: A prospective 1-year follow-up study.

    Science.gov (United States)

    Labad, J; Barbero, J D; Gutiérrez-Zotes, A; Montalvo, I; Creus, M; Cabezas, Á; Solé, M; Algora, M J; Garcia-Parés, G; Vilella, E

    2016-03-01

    The results of previous cross-sectional studies suggest that free thyroxine (FT4) levels are associated with cognitive abilities (particularly attention/vigilance) during the early stages of psychosis. We aimed to explore whether hypothalamic-pituitary-thyroid hormones predict cognitive changes in a 1-year longitudinal study following first episodes of psychosis (FEP). We studied 36 FEP patients and a control group of 50 healthy subjects (HS). Plasma levels of thyroid-stimulating hormone (TSH) and FT4 were measured. Cognitive assessment was performed with the MATRICS Cognitive Consensus Cognitive Battery (MCCB). FEP patients were assessed twice (baseline and after 1year), whereas HS were assessed only once. We compared cognitive changes at 1year between three groups based on baseline FT4 levels: 1) lowest quartile (Q1, FT41.54ng/dL). No differences in TSH or FT4 levels were found between HS and FEP patients. All participants had FT4 levels within the normal range. HS outperformed FEP patients in all cognitive tasks. In relation to the relationship between FT4 levels and cognitive changes, a U-shaped pattern was observed: FEP patients from the middle quartiles (Q2-Q3) improved in attention/vigilance, whereas both extreme quartiles (Q1 and Q4) showed a worsening in this cognitive domain over time. Patients with lower FT4 (Q1) showed poorer baseline attention; therefore, lower baseline FT4 levels predicted a poorer prognosis in terms of attention performance. Our study suggests that baseline FT4 levels are associated with changes in attention and vigilance performance over one year in FEP patients.

  4. Effect of aerobic training on EEG alpha asymmetry and depressive symptoms in the elderly: a 1-year follow-up study

    Directory of Open Access Journals (Sweden)

    A.C. Deslandes

    2010-06-01

    Full Text Available The effect of physical exercise on the treatment of depressive elderly adults has not been investigated thus far in terms of changes in cortical hemispheric activity. The objective of the present study was to identify changes in depressive symptoms, quality of life, and cortical asymmetry produced by aerobic activity. Elderly subjects with a diagnosis of major depressive disorder (DSM-IV were included. Twenty patients (70% females, 71 ± 3 years were divided into an exercise group (pharmacological treatment plus aerobic training and a control group (undergoing pharmacological treatment in a quasi-experimental design. Pharmacological treatment was maintained stable throughout the study (antidepressants and anxiolytics. Subjects were evaluated by depression scales (Beck Depression Inventory, Hamilton Depression Rating Scale, Montgomery-Asberg Depression Rating Scale and the Short Form Health Survey-36, and electroencephalographic measurements (frontal and parietal alpha asymmetry before and after 1 year of treatment. After 1 year, the control group showed a decrease in cortical activity on the right hemisphere (increase of alpha power, which was not observed in the exercise group. The exercise group showed a significant decrease of depressive symptoms, which was not observed in the control group. This result was also accompanied by improved treatment response and remission rate after 1 year of aerobic exercise associated with treatment. This study provides support for the effect of aerobic training on alpha activity and on depressive symptoms in elderly patients. Exercise facilitates the treatment of depressive elderly adults, leading to clinical and physical improvement and protecting against a decrease in cortical activity.

  5. Impact of Libido at 2 Weeks after Stroke on Risk of Stroke Recurrence at 1-Year in a Chinese Stroke Cohort Study

    Institute of Scientific and Technical Information of China (English)

    Jing-Jing Li; Huai-Wu Yuan; Chun-Xue Wang; Ben-Yan Luo; Jie Ruan; Ning Zhang; Yu-Zhi Shi

    2015-01-01

    Background:There were few studies on the relation between changes in libido and incidence of stroke recurrence.The aim of this study was to investigate the relationship between libido decrease at 2 weeks after stroke and recurrent stroke at 1-year.Methods:It is a multi-centered,prospective cohort study.The 14th item of the Hamilton Depression Rating Scale-17 was used to evaluate changes of libido in poststroke patients at 2 weeks.Stroke recurrence was defined as an aggravation of former neurological functional deficit,new local or overall symptoms,or stroke diagnosed at re-admission.Results:Among 2341 enrolled patients,1757 patients had completed follow-up data,533 (30.34%) patients had decreased libido at 2 weeks,and 166 (9.45%) patients had recurrent stroke at 1-year.Multivariate logistic regression analysis showed that,compared with patients with normal libido,the odds ratio (OR) of recurrent stroke in patients with decreased libido was reduced by 41% (OR =0.59,95% confidence interval [CI]:0.40-0.87).The correlation was more prominent among male patients (OR =0.52,95% CI:0.31-0.85) and patients of≥60 years of age (OR =0.57,95% CI:0.35-0.93).Conclusions:One out of three stroke patients in mainland China has decreased libido at 2 weeks after stroke.Decreased libido is a protective factor for stroke recurrence at 1-year,which is more prominent among older male patients.

  6. Long-term effects of 1-year maintenance training on physical functioning and health status in patients with COPD: A randomized controlled study

    DEFF Research Database (Denmark)

    Ringbaek, Thomas; Brondum, Eva; Martinez, Gerd;

    2010-01-01

    PURPOSE: To examine whether maintenance training (MT) for 1 year improved the long-term effects of a 7-week chronic obstructive pulmonary disease (COPD) rehabilitation program. METHODS: After a 7-week outpatient rehabilitation program, 96 patients with COPD were randomized to either an MT group (n...... study period. Primary effect parameters were Endurance Shuttle Walk Test (ESWT) time and health status (St. George's Respiratory Questionnaire, SGRQ). Secondary effect parameters were adherence to supervised training, dropout rates, and hospitalization. RESULTS: Compared with the control group, the MT...

  7. Cognitive function and neurodevelopmental outcomes in HIV-infected Children older than 1 year of age randomized to early versus deferred antiretroviral therapy: the PREDICT neurodevelopmental study.

    OpenAIRE

    Puthanakit, T.; Ananworanich, J.; Vonthanak, S.; Kosalaraksa, P; Hansudewechakul, R; Lugt, J. van der; Kerr, SJ; Kanjanavanit, S.; Ngampiyaskul, C.; Wongsawat, J; Luesomboon, W.; Vibol, U.; Pruksakaew, K; Suwarnlerk, T; Apornpong, T

    2013-01-01

    We previously reported similar AIDS-free survival at 3 years in children who were >1 year old initiating antiretroviral therapy (ART) and randomized to early versus deferred ART in the Pediatric Randomized to Early versus Deferred Initiation in Cambodia and Thailand (PREDICT) study. We now report neurodevelopmental outcomes.Two hundred eighty-four HIV-infected Thai and Cambodian children aged 1-12 years with CD4 counts between 15% and 24% and no AIDS-defining illness were randomized to initia...

  8. Hospitalization for Pneumonia is Associated With Decreased 1-Year Survival in Patients With Type 2 Diabetes: Results From a Prospective Cohort Study.

    Science.gov (United States)

    Falcone, Marco; Tiseo, Giusy; Russo, Alessandro; Giordo, Laura; Manzini, Elisa; Bertazzoni, Giuliano; Palange, Paolo; Taliani, Gloria; Cangemi, Roberto; Farcomeni, Alessio; Vullo, Vincenzo; Violi, Francesco; Venditti, Mario

    2016-02-01

    Diabetes mellitus is a frequent comorbid conditions among patients with pneumonia living in the community.The aim of our study is to evaluate the impact of hospitalization for pneumonia on early (30 day) and late mortality (1 year) in patients with type 2 diabetes mellitus.Prospective comparative cohort study of 203 patients with type 2 diabetes hospitalized for pneumonia versus 206 patients with diabetes hospitalized for other noninfectious causes from January 2012 to December 2013 at Policlinico Umberto I (Rome). Enrolled patients were followed up to discharge and up to 1 year after initial hospital admission or death.Overall, 203 patients with type 2 diabetes admitted to hospital for pneumonia were compared to 206 patients with type 2 diabetes admitted for other causes (39.3% decompensated diabetes, 21.4% cerebrovascular diseases, 9.2% renal failure, 8.3% acute myocardial infarction, and 21.8% other causes). Compared to control patients, those admitted for pneumonia showed a higher 30-day (10.8% vs 1%, P pneumonia had a higher incidence of moderate to severe chronic kidney disease, hemodialysis, and malnutrition were more likely to present with a mental status deterioration, and had a higher number of cardiovascular events during the follow-up period. Cox regression analysis found age, Charlson comorbidity index, pH pneumonia as variables independently associated with mortality.Hospitalization for pneumonia is associated with decreased 1-year survival in patients with type 2 diabetes, and appears to be a major determinant of long-term outcome in these patients.

  9. Long-Term Course of Failed Back Surgery Syndrome (FBSS) Patients Receiving Integrative Korean Medicine Treatment: A 1 Year Prospective Observational Multicenter Study

    Science.gov (United States)

    Lee, Jinho; Shin, Joon-Shik; Lee, Yoon Jae; Kim, Me-riong; Choi, Areum; Lee, Jun-Hwan; Shin, Kyung-Min; Shin, Byung-Cheul; Cho, Jae-Heung

    2017-01-01

    Background With increase of spine surgeries, failed back surgery syndrome (FBSS) prevalence is also rising. While complementary and alternative medicine (CAM) is commonly used for low back pain (LBP), there are no studies reporting use of integrative Korean medicine in FBSS patients. Methods Patients with pain continuing after back surgery or recurring within 1 year and visual analogue scale (VAS) of LBP or leg pain of ≥6 (total n = 120) were recruited at 2 hospital sites from November 2011 to September 2014. Weekly sessions of integrative Korean medicine treatment were conducted for 16 weeks (herbal medicine, acupuncture/electroacupuncture, pharmacopuncture/bee venom pharmacopuncture, and Chuna manual therapy) with additional follow-ups at 24 weeks and 1 year. Outcome measures included VAS of LBP and leg pain (primary outcome), Oswestry Disability Index (ODI), Short-Form 36 (SF-36), medical use, and patient global impression of change (PGIC). Results VAS of LBP and leg pain improved at 6 months (LBP from 6.1±2.0 at baseline to 2.9±2.3; and leg pain from 5.4±2.6 to 2.4±2.5, respectively). Eighty patients (66.7%) showed improvement of 50% or more in main pain of LBP or leg pain from baseline. Disability and quality of life also improved at 6 months (ODI from 41.3±12.3 at baseline to 23.6±13.6; and SF-36 from 42.8±14.5 to 62.7±16.8). At 1 year follow-up, conventional medical management use decreased, improvement in pain and disability was maintained, and 79.2% reported improvement of PGIC. Conclusions Despite limitations as an observational study, integrative Korean medicine treatment showed positive results in pain, function, and quality of life of FBSS patients. PMID:28129399

  10. Diffuse excessive high signal intensity in low-risk preterm infants at term-equivalent age does not predict outcome at 1 year: a prospective study

    Energy Technology Data Exchange (ETDEWEB)

    Leitner, Yael [Tel Aviv Sourasky Medical Centre, Child Development Centre, Dana-Dwek Children' s Hospital, Tel Aviv (Israel); Tel Aviv University, Sackler Faculty of Medicine, Tel Aviv (Israel); Weinstein, Maya [Tel Aviv Sourasky Medical Centre, Functional Brain Centre, The Wohl Institute for Advanced Imaging, Tel Aviv (Israel); Bar Ilan University, Department of Psychology, Gonda Multidisciplinary Brain Research Centre, Ramat-Gan (Israel); Myers, Vicki [Tel Aviv Sourasky Medical Centre, Functional Brain Centre, The Wohl Institute for Advanced Imaging, Tel Aviv (Israel); Uliel, Shimrit; Geva, Karen [Tel Aviv Sourasky Medical Centre, Child Development Centre, Dana-Dwek Children' s Hospital, Tel Aviv (Israel); Berger, Irit; Marom, Ronella [Tel Aviv Sourasky Medical Centre, Department of Neonatology, Lis Maternity Hospital, Tel Aviv (Israel); Tel Aviv University, Sackler Faculty of Medicine, Tel Aviv (Israel); Bashat, Dafna Ben [Tel Aviv University, Sackler Faculty of Medicine, Tel Aviv (Israel); Tel Aviv University, Sagol School of Neuroscience, Tel Aviv (Israel); Ben-Sira, Liat [Tel Aviv University, Sackler Faculty of Medicine, Tel Aviv (Israel); Tel Aviv Sourasky Medical Centre, Department of Radiology, Tel Aviv (Israel); Geva, Ronny [Bar Ilan University, Department of Psychology, Gonda Multidisciplinary Brain Research Centre, Ramat-Gan (Israel); Gross-Tsur, Varda [Shaare-Zedek Medical Centre, Neuropediatric Unit, Jerusalem (Israel)

    2014-08-15

    The outcome of premature infants with only diffuse excessive high signal intensity (DEHSI) is not clear. We explored the relationship between DEHSI, white matter (WM) diffusion characteristics, perinatal characteristics, and neurobehavioral outcome at 1 year in a homogenous group of preterm infants without major brain abnormalities. Fifty-eight preterm infants, gestational age 29 ± 2.6 weeks, underwent an MRI at term-equivalent age (TEA). Griffiths Mental Developmental Scales, neurological assessment, and Parental Stress Index (PSI) were performed at 1 year corrected age. These measures were compared between preterm infants according to DEHSI classification (none, mild, moderate). Diffusion tensor imaging was used in major WM volumes of interest to objectively measure the degree of WM maturation. No significant differences were detected in the perinatal risk characteristics, neurobehavioral outcome, and PSI at 1 year between infants with different DEHSI classifications. In infants with DEHSI, increased axial and radial diffusivities were detected in the optic radiations, centrum semiovale, and posterior limb of the internal capsule, indicating less advanced maturation of the WM. Significant correlations were detected between the time interval from birth to MRI and the WM microstructure in infants without DEHSI. DEHSI in premature infants is neither a predictive measure for short-term adverse neurobehavioral outcome nor related to perinatal risk characteristics. Extrauterine exposure time had a differential effect on WM maturational trajectories in infants with DEHSI compared to those without. We suggest DEHSI may represent an alteration in WM maturational characteristics. Further follow-up studies may verify later consequences of DEHSI in premature infants. (orig.)

  11. Prospective study of telephone calls to a hotline for infectious disease consultation: analysis of 7,863 solicited consultations over a 1-year period.

    Science.gov (United States)

    Gennai, S; François, P; Sellier, E; Vittoz, J-P; Hincky-Vitrat, V; Pavese, P

    2011-04-01

    To respond to the increasing requests of non-infectious disease physicians for access to infectious diseases expertise, a hotline was created in the infectious diseases consultation (IDC) unit of the Grenoble university-affiliated hospital (GUH). This study describes the patterns of solicited consultations provided by the hotline during a 1-year period. We conducted a prospective study of consecutive solicited IDCs requested by physicians in 2008. A total of 7,863 consultations were requested by physicians over 1 year; 4,407 (56.0%) by ambulatory physicians, 2,933 (37.3%) by GUH physicians, and 523 (6.7%) by physicians in public or private hospitals. The majority of consultations were requested via cell phone (58.7%). The main reasons for requesting a consultation were related to antimicrobial treatment for hospital-based physicians and prophylaxis for ambulatory physicians (p hotline attests to an important need for such expertise consultation, both in hospitals and in ambulatory medicine.

  12. Long-term effects of St. John's wort (Hypericum perforatum) treatment: a 1-year safety study in mild to moderate depression.

    Science.gov (United States)

    Brattström, Axel

    2009-04-01

    Long-term safety and the effects of a St. John's wort (SJW) extract Ze 117 (Hypericum perforatum) were evaluated in the treatment of patients with depression. An open multicentre safety study with 440 out-patients suffering from mild to moderate depression according to ICD-10 was conducted. Patients were treated for up to 1 year with 500 mg St. John's wort extract per day (Ze 117). Evaluation criteria were safety (adverse event frequency) and influence on depression (HAM-D, CGI). Two hundred and seventeen (49%) patients reported 504 adverse events, 30 (6%) of which were possibly or probably related to the treatment. Gastrointestinal and skin complaints were the most common events associated with treatment. No age-related difference in the safety of the applied medication was found. The long-term intake of up to 1 year of the study medication did not result in any changes in clinical chemistry and electrocardiogram recordings. Body mass index (BMI) did not change either. Mean HAM-D scores decreased steadily from 20.58 at baseline to 12.07 at week 26 and to 11.18 at week 52. Mean CGI scores decreased from 3.99 to 2.20 at week 26 and 2.19 at week 52. Therefore, St. John's wort extract ZE 117 is a safe and effective way to treat mild to moderate depression over long periods of time, and therefore seems especially suitable for a relapse prevention.

  13. The Development of Musical Skills of Underprivileged Children Over the Course of 1 Year: A Study in the Context of an El Sistema-Inspired Program.

    Science.gov (United States)

    Ilari, Beatriz S; Keller, Patrick; Damasio, Hanna; Habibi, Assal

    2016-01-01

    Developmental research in music has typically centered on the study of single musical skills (e.g., singing, listening) and has been conducted with middle class children who learn music in schools and conservatories. Information on the musical development of children from different social strata, who are enrolled in community-based music programs, remains elusive. This study examined the development of musical skills in underprivileged children who were attending an El Sistema-inspired program in Los Angeles. We investigated how children, predominantly of Latino ethnicity, developed musically with respect to the following musical skills - pitch and rhythmic discrimination, pitch matching, singing a song from memory, and rhythmic entrainment - over the course of 1 year. Results suggested that participation in an El Sistema-inspired program affects children's musical development in distinct ways; with pitch perception and production skills developing faster than rhythmic skills. Furthermore, children from the same ethnic and social background, who did not participate in the El Sistema-inspired music program, showed a decline in singing and pitch discrimination skills over the course of 1 year. Taken together, these results are consistent with the idea of musical development as a complex, spiraling and recursive process that is influenced by several factors including type of musical training. Implications for future research are outlined.

  14. Thermal Aging Study of a Dow Corning SE 1700 Porous Structure Made by Direct Ink Writing: 1-Year Results and Long-Term Predictions

    Energy Technology Data Exchange (ETDEWEB)

    Small, Ward [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Pearson, Mark A. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Maiti, Amitesh [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Metz, Thomas R. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Duoss, Eric B. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Wilson, Thomas S. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2015-11-13

    Dow Corning SE 1700 (reinforced polydimethylsiloxane) porous structures were made by direct ink writing (DIW). The specimens (~50% porosity) were subjected to various compressive strains (15, 30, 45%) and temperatures (room temperature, 35, 50, 70°C) in a nitrogen atmosphere (active purge) for 1 year. Compression set and load retention of the aged specimens were measured periodically during the study. Compression set increased with strain and temperature. After 1 year, specimens aged at room temperature, 35, and 50°C showed ~10% compression set (relative to the applied compressive deflection), while those aged at 70°C showed 20-40%. Due to the increasing compression set, load retention decreased with temperature, ranging from ~90% at room temperature to ~60-80% at 70°C. Long-term compression set and load retention at room temperature were predicted by applying time-temperature superposition (TTS). The predictions show compression set relative to the compressive deflection will be ~10-15% with ~70-90% load retention after 50 years at 15-45% strain, suggesting the material will continue to be mechanically functional. Comparison of the results to previously acquired data for cellular (M97*, M9760, M9763) and RTV (S5370) silicone foams suggests that the SE 1700 DIW porous specimens are on par with, or outperform, the legacy foams.

  15. Is "football for all" safe for all? Cross-sectional study of disparities as determinants of 1-year injury prevalence in youth football programs.

    Directory of Open Access Journals (Sweden)

    Örjan Dahlström

    Full Text Available BACKGROUND: Football (soccer is endorsed as a health-promoting physical activity worldwide. When football programs are introduced as part of general health promotion programs, equal access and limitation of pre-participation disparities with regard to injury risk are important. The aim of this study was to explore if disparity with regard to parents' educational level, player body mass index (BMI, and self-reported health are determinants of football injury in community-based football programs, separately or in interaction with age or gender. METHODOLOGY/PRINCIPAL FINDINGS: Four community football clubs with 1230 youth players agreed to participate in the cross-sectional study during the 2006 season. The study constructs (parents' educational level, player BMI, and self-reported health were operationalized into questionnaire items. The 1-year prevalence of football injury was defined as the primary outcome measure. Data were collected via a postal survey and analyzed using a series of hierarchical statistical computations investigating associations with the primary outcome measure and interactions between the study variables. The survey was returned by 827 (67.2% youth players. The 1-year injury prevalence increased with age. For youths with parents with higher formal education, boys reported more injuries and girls reported fewer injuries than expected; for youths with lower educated parents there was a tendency towards the opposite pattern. Youths reporting injuries had higher standardized BMI compared with youths not reporting injuries. Children not reporting full health were slightly overrepresented among those reporting injuries and underrepresented for those reporting no injury. CONCLUSION: Pre-participation disparities in terms of parents' educational level, through interaction with gender, BMI, and self-reported general health are associated with increased injury risk in community-based youth football. When introduced as a general health

  16. Factors associated with adherence to nucleos(t)ide analogs in chronic hepatitis B patients: results from a 1-year follow-up study.

    Science.gov (United States)

    Peng, Jie; Yin, Junhua; Cai, Shaohang; Yu, Tao; Zhong, Chunxiu

    2015-01-01

    Little is known about the factors associated with patient compliance with nucleos(t)ide analog (NUC) treatment for chronic hepatitis B (CHB). The purpose of this study was to examine the association between sociodemographic and clinical characteristics and adherence to NUCs among patients with CHB. A total of 211 CHB patients receiving NUC monotherapy were asked to report the number of prescribed doses of medication they had taken during the last 90 days. A total of four 3-month adherence scores were averaged to obtain a combined rate of NUC adherence during a 1-year follow up period. The mean age of the patients was 29.6 years, 79% were men, and 68% had no prior NUC treatment for CHB. Females, patients without a previous NUC treatment, and those who had NUC drug resistance showed better adherence to NUC treatment, and compliance was better with telbivudine than with lamivudine and entecavir.

  17. Cut off values of laser fluorescence for different storage methods at different time intervals in comparison to frozen condition: A 1 year in vitro study

    Directory of Open Access Journals (Sweden)

    Rudra Kaul

    2014-01-01

    Full Text Available Aims: The aim of the following study is to evaluate the change in laser fluorescence (LF values for extracted teeth stored in different solutions over 1 year period, to give cut-off values for different storage media at different time intervals to get them at par with the in vivo conditions and to see which medium gives best results with the least change in LF values and while enhancing the validity of DIAGNOdent in research. Materials and Methods: Ninety extracted teeth selected, from a pool of frozen teeth, were divided into nine groups of 10 each. Specimens in Groups 1-8 were stored in 1% chloramine, 10% formalin, 10% buffered formalin, 0.02% thymol, 0.12% chlorhexidine, 3% sodium hypochlorite, a commercially available saliva substitute-Wet Mouth (ICPA Pharmaceuticals and normal saline respectively at 4°C. The last group was stored under frozen condition at −20°C without contact with any storage solution. DIAGNOdent was used to measure the change the LF values at day 30, 45, 60, 160 and 365. Statistical Analysis Used: The mean change in LF values in different storage mediums at different time intervals were compared using two-way ANOVA. Results: At the end of 1 year, significant decrease in fluorescence (P < 0.05 was observed in Groups 1-8. Maximum drop in LF values occurred between day 1 and 30. Group 9 (frozen specimens did not significantly change their fluorescence response. Conclusions: An inevitable change in LF takes place due to various storage media commonly used in dental research at different time intervals. The values obtained from our study can remove the bias caused by the storage media and the values of LF thus obtained can hence be conveniently extrapolated to the in vivo condition.

  18. Cut off values of laser fluorescence for different storage methods at different time intervals in comparison to frozen condition: A 1 year in vitro study

    Science.gov (United States)

    Kaul, Rudra; Kaul, Vibhuti; Farooq, Riyaz; Wazir, Nikhil Dev; Khateeb, Shafayat Ullah; Malik, Altaf H; Masoodi, Ajaz Amin

    2014-01-01

    Aims: The aim of the following study is to evaluate the change in laser fluorescence (LF) values for extracted teeth stored in different solutions over 1 year period, to give cut-off values for different storage media at different time intervals to get them at par with the in vivo conditions and to see which medium gives best results with the least change in LF values and while enhancing the validity of DIAGNOdent in research. Materials and Methods: Ninety extracted teeth selected, from a pool of frozen teeth, were divided into nine groups of 10 each. Specimens in Groups 1-8 were stored in 1% chloramine, 10% formalin, 10% buffered formalin, 0.02% thymol, 0.12% chlorhexidine, 3% sodium hypochlorite, a commercially available saliva substitute-Wet Mouth (ICPA Pharmaceuticals) and normal saline respectively at 4°C. The last group was stored under frozen condition at −20°C without contact with any storage solution. DIAGNOdent was used to measure the change the LF values at day 30, 45, 60, 160 and 365. Statistical Analysis Used: The mean change in LF values in different storage mediums at different time intervals were compared using two-way ANOVA. Results: At the end of 1 year, significant decrease in fluorescence (P < 0.05) was observed in Groups 1-8. Maximum drop in LF values occurred between day 1 and 30. Group 9 (frozen specimens) did not significantly change their fluorescence response. Conclusions: An inevitable change in LF takes place due to various storage media commonly used in dental research at different time intervals. The values obtained from our study can remove the bias caused by the storage media and the values of LF thus obtained can hence be conveniently extrapolated to the in vivo condition. PMID:24778506

  19. Predictors and dietary consequences of frequent intake of high-sugar, low-nutrient foods in 1-year-old children participating in the ABIS study.

    Science.gov (United States)

    Brekke, Hilde K; van Odijk, Jenny; Ludvigsson, Johnny

    2007-01-01

    Foods rich in sugar have been suggested to contribute to the increasing prevalence of obesity in children. The aim of this report is to investigate the dietary pattern in 1-year-old children who frequently receive foods rich in sugar but low in nutrients and to study associated demographic and parental factors. During 1977-9, 21,700 infants were invited to participate in this prospective, population-based, longitudinal cohort study. Screening questionnaires were completed for 16,070 infants after delivery. Follow-up questionnaires from 10,762 children at 1 year of age are included in the analysis. It was found that 24% of the children received sweets/pastries more often than one or two times per week. They had a higher intake of French fries, potato crisps and cream as well as a lower intake of fruit and vegetables. A frequent intake of sugar-rich, low-nutrient foods was significantly associated with several maternal factors (high intake of sweets/pastries during pregnancy, young age, mother living alone) as well as presence of older siblings. Maternal smoking during pregnancy and maternal overweight were of borderline significance. Parental education level was inversely associated with the frequency of intake of sweets/pastries in the child. Children who frequently receive sweets/pastries also have an otherwise unfavourable dietary pattern. Several parental and demographic factors were associated with this feeding pattern, especially high intake of sweets/pastries during pregnancy. Screening of pregnant women for risk predictors like consumption of sweets/pastries, young age and smoking could be possible ways of identifying children at future risk for low dietary quality.

  20. Deferasirox reduces iron overload significantly in nontransfusion-dependent thalassemia: 1-year results from a prospective, randomized, double-blind, placebo-controlled study.

    Science.gov (United States)

    Taher, Ali T; Porter, John; Viprakasit, Vip; Kattamis, Antonis; Chuncharunee, Suporn; Sutcharitchan, Pranee; Siritanaratkul, Noppadol; Galanello, Renzo; Karakas, Zeynep; Lawniczek, Tomasz; Ros, Jacqueline; Zhang, Yiyun; Habr, Dany; Cappellini, Maria Domenica

    2012-08-02

    Nontransfusion-dependent thalassemia (NTDT) patients may develop iron overload and its associated complications despite receiving only occasional or no transfusions. The present 1-year, randomized, double-blind, placebo-controlled THALASSA (Assessment of Exjade in Nontransfusion-Dependent Thalassemia) trial assessed the efficacy and safety of deferasirox in iron-overloaded NTDT patients. A total of 166 patients were randomized in a 2:1:2:1 ratio to starting doses of 5 or 10 mg/kg/d of deferasirox or placebo. The means ± SD of the actual deferasirox doses received over the duration of the study in the 5 and 10 mg/kg/d starting dose cohorts were 5.7 ± 1.4 and 11.5 ± 2.9 mg/kg/d, respectively. At 1 year, the liver iron concentration (LIC) decreased significantly compared with placebo (least-squares mean [LSM] ± SEM, -2.33 ± 0.7 mg Fe/g dry weight [dw], P = .001, and -4.18 ± 0.69 mg Fe/g dw, P deferasirox groups, respectively (baseline values [means ± SD], 13.11 ± 7.29 and 14.56 ± 7.92 mg Fe/g dw, respectively). Similarly, serum ferritin decreased significantly compared with placebo by LSM -235 and -337 ng/mL for the deferasirox 5 and 10 mg/kg/d groups, respectively (P deferasirox significantly reduces iron overload in NTDT patients with a frequency of overall adverse events similar to placebo.

  1. A 1-year follow-up study exploring the associations between perception of illness and health-related quality of life in persons with chronic obstructive pulmonary disease

    Directory of Open Access Journals (Sweden)

    Bonsaksen T

    2013-12-01

    Full Text Available Tore Bonsaksen,1 Stacey Haukeland-Parker,2 Anners Lerdal,3,4 May Solveig Fagermoen4,5 1Department of Occupational Therapy, Prosthetics and Orthotics, Faculty of Health Sciences, Oslo and Akershus University College of Applied Sciences, Oslo, Norway; 2Department of Physiotherapy, Østfold Hospital Trust, Fredrikstad, Norway; 3Research Department, Lovisenberg Diakonale Hospital, Oslo, Norway; 4Department of Nursing Science, Institute of Health and Society, University of Oslo, Oslo, Norway; 5Department of Gastroenterology, Division of Medicine, Oslo University Hospital, Oslo, Norway Abstract: Chronic obstructive pulmonary disease (COPD is a progressive respiratory disease with an increasing prevalence worldwide. Its potential consequences, including reduced function and reduced social participation, are likely to be associated with decreased health-related quality of life (HRQoL. However, illness perceptions and self-efficacy beliefs may also play a part in determining HRQoL in persons with COPD. The aim of this study was to explore the relationships between illness perceptions, self-efficacy, and HRQoL in a sample of persons with COPD in a longitudinal perspective. The context of the study was a patient education course from which the participants were recruited. Data concerning sociodemographic variables, social support, physical activity, illness perceptions, general self-efficacy, and HRQoL were collected before the course started and 1 year after completion. Linear regression was used in the analyses. The results showed that less consequences and less symptoms (identity were associated with higher physical HRQoL (PCS at baseline and at 1-year follow-up. Less emotional response was similarly associated with higher mental HRQoL (MCS at both time points. Lower self-efficacy showed a borderline significant association with higher PCS at baseline, but was unrelated to MCS at both time points. Self-efficacy showed no influence on the associations

  2. Workplace Issues in Extension--A Delphi Study of Extension Educators

    Science.gov (United States)

    Kroth, Michael; Peutz, Joey

    2011-01-01

    Using the Delphi technique, expert Extension educators identified and prioritized those workplace issues they believe will be the most important to attract, motivate, and retain Extension educators/agents over the next 5 to 7 years. Obtaining and then utilizing a talented, highly motivated workforce during a period when many will be retiring will…

  3. Low-cost, low-field dedicated extremity magnetic resonance imaging in early rheumatoid arthritis: a 1-year follow-up study

    DEFF Research Database (Denmark)

    Lindegaard, H.M.; Vallø, J.; Hørslev-Petersen, K.;

    2006-01-01

    OBJECTIVE: To study the ability of low-cost low-field dedicated extremity magnetic resonance imaging (E-MRI) to assess and predict erosive joint damage in the wrist and metacarpophalangeal (MCP) joints of patients with early rheumatoid arthritis. METHODS: 24 previously untreated patients with rhe......OBJECTIVE: To study the ability of low-cost low-field dedicated extremity magnetic resonance imaging (E-MRI) to assess and predict erosive joint damage in the wrist and metacarpophalangeal (MCP) joints of patients with early rheumatoid arthritis. METHODS: 24 previously untreated patients...... with rheumatoid arthritis with joint symptoms for treatment with conventional clinical or biochemical examinations, x rays of both hands and wrists, and E-MRI of the dominant wrist and MCP joints. RESULTS: At baseline, all...... patients showed magnetic resonance imaging (MRI) synovitis, and MRI erosions were detected in 21 bones (10 patients). 6 (29%) of these, distributed among two patients, were seen on x ray. One x ray erosion was not detected by MRI. At 1 year, MRI and x ray detected 15 and 8 new erosions, respectively...

  4. Language Development: 1 Year Olds

    Science.gov (United States)

    ... Stages Listen Español Text Size Email Print Share Language Development: 1 Year Olds Page Content Article Body ... assured, it’s not your imagination. He’s developing his language and comprehension skills right on schedule. This giant ...

  5. Factors associated with adherence to nucleos(tide analogs in chronic hepatitis B patients: results from a 1-year follow-up study

    Directory of Open Access Journals (Sweden)

    Peng J

    2015-01-01

    Full Text Available Jie Peng, Junhua Yin, Shaohang Cai, Tao Yu, Chunxiu Zhong Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong Province, People’s Republic of China Abstract: Little is known about the factors associated with patient compliance with nucleos(tide analog (NUC treatment for chronic hepatitis B (CHB. The purpose of this study was to examine the association between sociodemographic and clinical characteristics and adherence to NUCs among patients with CHB. A total of 211 CHB patients receiving NUC monotherapy were asked to report the number of prescribed doses of medication they had taken during the last 90 days. A total of four 3-month adherence scores were averaged to obtain a combined rate of NUC adherence during a 1-year follow up period. The mean age of the patients was 29.6 years, 79% were men, and 68% had no prior NUC treatment for CHB. Females, patients without a previous NUC treatment, and those who had NUC drug resistance showed better adherence to NUC treatment, and compliance was better with telbivudine than with lamivudine and entecavir. Keywords: chronic hepatitis B, nucleos(tide analogues, adherence, follow-up, resistance

  6. Long-term graft survival after conversion from cyclosporin to azathioprine 1 year after renal transplantation. A prospective, randomized study from 1 to 6 years after transplantation.

    Science.gov (United States)

    Pedersen, E B; Hansen, H E; Kornerup, H J; Madsen, S; Sørensen, A W

    1993-01-01

    Cyclosporin has improved graft survival after renal transplantation, but cyclosporin nephrotoxicity is a severe clinical problem. Conversion from cyclosporin to azathioprine 1 year after transplantation might improve long-term graft survival by avoidance of cyclosporin nephrotoxicity. After treatment with cyclosporin and prednisolone during the first year after renal transplantation, 106 patients were consecutively randomized to treatment with either azathioprine and prednisolone or cyclosporin and prednisolone in a prospective, controlled study during the following 5 years, i.e. 6 years after transplantation. Actuarial estimates of graft survival rates after inclusion in the study were obtained by the product-limit method of Kaplan-Meier, and the Mantel-Cox log rank test was used to compare the two treatment regimens. When the end-points in the analyses were cessation of graft function or withdrawal of immunosuppressive treatment due to side-effects, and when patients alive with graft function or who had died with a functioning graft were treated as censored observations, graft survival 5 years after inclusion in the study was 57.7 +/- 5.2% in the total material and was the same in both the azathioprine group (52.4 +/- 7.7%) and the cyclosporin group (63.3 +/- 6.7%) (log rank = 0.40, P = 0.53). When cessation of graft function was the only end-point, graft survival 5 years after inclusion in the study was 73.7 +/- 5.2% for the total material with no significant differences between the two groups (log rank = 0.58, P = 0.45).(ABSTRACT TRUNCATED AT 250 WORDS)

  7. Outcomes of West Nile encephalitis patients after 1 year of West Nile encephalitis outbreak in Kerala, India: A follow-up study.

    Science.gov (United States)

    Balakrishnan, Anukumar; Thekkekara, Romy Jose; Tandale, Babasheb V

    2016-11-01

    We reported an acute encephalitis syndrome outbreak in Alappuzha district in Kerala, India during the year 2011. The etiology was confirmed to be West Nile virus lineage 1. Many encephalitis patients from this outbreak exhibited neurological sequelae post recovery. This study was aimed to assess the clinical outcomes of West Nile encephalitis confirmed case-patients after 1 year of acute illness. Forty West Nile virus confirmed encephalitis patients were selected from the 2011 outbreak was included in this study. Out of 40 cases, only 30 survived after 12 months. Among these 30 recovered case-patients, 27 (90%) consented for clinical follow-up and 23 (73.67%) of them consented for assessment of cognitive impairment and deposition of blood sample for antibody testing. The most common symptom observed in these patients was fatigue (25.93%). Other symptoms included dizziness (7.4%), decreased sense of hearing (7.4%) and decreased sense of smell (7.4%). Reduced power in limbs was found in 33.33% of the cases. Most of the patients (23.1%) were dependent on others for normal daily living activities. The patients also had probable risk of poor cognition (29.41%) and dementia (57.14%). None of the patients were positive for WNV specific IgM at 12 months post onset of disease. The study concluded that the long-term sequelae were noticed in WNV positive patients. Prevention effort should be focused on the elderly (≥60 years old) people who have a higher risk of severe sequelae. The state health authorities should create awareness among people in order to prevent the transmission of disease. J. Med. Virol. 88:1856-1861, 2016. © 2016 Wiley Periodicals, Inc.

  8. A Conceptual Framework for Determining Training Needs of Extension Agents Applied to Dairy Science. The Findings from Extension Studies.

    Science.gov (United States)

    Verma, Satish

    A summary of an Extension Education dissertation on a study to develop a framework of curriculum and learning theory features, to determine needs of Extension agents, and to show its application to dairy science is presented. Tyler's rationale for deriving educational objectives (curriculum theory) and Bloom's taxonomy of cognitive behavior…

  9. Immediate, non-submerged, root-analogue direct laser metal sintering (DLMS) implants: a 1-year prospective study on 15 patients.

    Science.gov (United States)

    Mangano, Francesco Guido; De Franco, Michele; Caprioglio, Alberto; Macchi, Aldo; Piattelli, Adriano; Mangano, Carlo

    2014-07-01

    This study evaluated the 1-year survival and success rate of root-analogue direct laser metal sintering (DLMS) implants, placed into the extraction sockets of 15 patients. DLMS is a technology which allows solids with complex geometry to be fabricated by annealing metal powder microparticles in a focused laser beam, according to a computer-generated three-dimensional (3D) model; the fabrication process involves the laser-induced fusion of titanium microparticles, in order to build, layer-by-layer, the desired object. Cone-beam computed tomography (CBCT) acquisition and 3D image conversion, combined with the DLMS process, allow the fabrication of custom-made, root-analogue implants (RAIs). CBCT images of 15 non-restorable premolars (eight maxilla; seven mandible) were acquired and transformed into 3D models: from these, custom-made, root-analogue DLMS implants with integral abutment were fabricated. Immediately after tooth extraction, the RAIs were placed in the sockets and restored with a single crown. One year after implant placement, clinical and radiographic parameters were assessed: success criteria included absence of pain, suppuration, and exudation; absence of implant mobility and absence of continuous peri-implant radiolucency; distance between the implant shoulder and the first visible bone-to-implant contact implants were lost, for a survival rate of 100 %. All implants were stable, with no signs of infection. The good conditions of the peri-implant tissues were confirmed by the radiographic examination, with a mean DIB of 0.7 mm (±0.2). The possibility of fabricating custom-made, RAI DLMS implants opens new interesting horizons for immediate placement of dental implants.

  10. Long-term effects of 1-year maintenance training on physical functioning and health status in patients with COPD: A randomized controlled study

    DEFF Research Database (Denmark)

    Ringbaek, Thomas; Brondum, Eva; Martinez, Gerd;

    2010-01-01

    PURPOSE: To examine whether maintenance training (MT) for 1 year improved the long-term effects of a 7-week chronic obstructive pulmonary disease (COPD) rehabilitation program. METHODS: After a 7-week outpatient rehabilitation program, 96 patients with COPD were randomized to either an MT group (...

  11. Characterization of Retinal Disease Progression in a 1-Year Longitudinal Study of Eyes With Mild Nonproliferative Retinopathy in Diabetes Type 2

    DEFF Research Database (Denmark)

    Ribeiro, Luisa; Bandello, Francesco; Tejerina, Amparo Navea

    2015-01-01

    PURPOSE: To identify eyes of patients with diabetes type 2 that show progression of retinal disease within a 1-year period using noninvasive techniques. METHODS: Three hundred seventy-four type 2 diabetic patients with mild nonproliferative diabetic retinopathy (Early Treatment Diabetic Retinopat...

  12. Power Extension Package (PEP) system definition extension, orbital service module systems analysis study. Volume 2: PEP

    Science.gov (United States)

    1979-01-01

    User power, duration, and orbit requirements, which were the prime factors influencing power extension package (PEP) design, are discussed. A representative configuration of the PEP concept is presented and the major elements of the system are described as well as the PEP-to-Orbiter and remote manipulator interface provisions.

  13. Risk factors for development of non-specific musculoskeletal pain in preteens and early adolescents: a prospective 1-year follow-up study

    Directory of Open Access Journals (Sweden)

    Auvinen Anssi

    2007-05-01

    Full Text Available Abstract Background Musculoskeletal pain symptoms are common in children and adolescents. These symptoms have a negative impact on children's physical and emotional well-being, but their underlying aetiology and risk factors are still poorly understood. Most of the previous cohort studies were conducted among mid and/or late adolescents and were mainly focused on a specific pain location (e.g. low back pain or neck pain. The purpose of this study is to estimate occurrence of new-onset pain symptoms, in all musculoskeletal locations, in preteens and early adolescents and investigate risk factors for development of these symptoms. Methods 1756 schoolchildren (mean age 10.8 were recruited from schools in southern Finland. Information was extracted as to whether they experienced musculoskeletal pain and a total of 1192 children were identified as free of musculoskeletal pain symptoms. Information was collected on factors which could potentially predict the development of musculoskeletal pain: headache, abdominal pain, sadness/feeling down, day-time tiredness, difficulty in falling asleep, waking up during nights, level of physical activity and hypermobility. These children were followed-up 1-year later and those with new episodes of non-traumatic and traumatic musculoskeletal pain symptoms were identified. Results A total of 1113 schoolchildren (93% of baseline pain-free children were found at one-year follow-up. New episodes of musculoskeletal pain were reported by 21.5% of these children. Of them 19.4% reported non-traumatic pain and 4.0% reported traumatic pain. The neck was the most commonly reported site with non-traumatic pain, while the lower limb was the most common site for traumatic pain. The independent risk factors for non-traumatic musculoskeletal pain were headache (OR = 1.68, [95% CI 1.16–2.44] and day-time tiredness (OR = 1.53, [95% CI 1.03–2.26]. The risk factors for traumatic musculoskeletal pain were vigorous exercise (OR = 3

  14. Study of oral Ketoconazole on recurrent & extensive Pityriasis Versicolor

    Directory of Open Access Journals (Sweden)

    Moghaddami M

    1997-04-01

    Full Text Available Several topical agents have been used for treating Pityriasis versicolor. But the main problem is recurrence. In this study 82 patients with recurrent and/or extensive from of infection were treated with oral Ketoconazole. 200 mg once daily for a maximum of 4 weeks. Seventeen patients have been infected for the first time and sixty five for the several times. The duration of disease in most cases (35.4% were between 1-3 years. Out of 82 studied patients only 60 cases were referred for follow up. The clinical and mycological cure were seen in 54 cases (90% after 15 days therapy. In other 6 patients after 15 days the lesions have not cured completely so the treatment was continued for other 2 weeks, but after that, only one of them referred to the clinic, which treatment extended with topical therapy.

  15. Clinical Performance and Safety of 108 SpineJack Implantations: 1-Year Results of a Prospective Multicentre Single-Arm Registry Study

    Directory of Open Access Journals (Sweden)

    David Noriega

    2015-01-01

    Full Text Available This prospective, consecutive, multicentre observational registry aimed to confirm the safety and clinical performance of the SpineJack system for the treatment of vertebral compression fractures (VCF of traumatic origin. We enrolled 103 patients (median age: 61.6 years with 108 VCF due to trauma, or traumatic VCF with associated osteoporosis. Primary outcome was back pain intensity (VAS. Secondary outcomes were Oswestry Disability Index (ODI, EuroQol-VAS, and analgesic consumption. 48 hours after surgery, a median relative decrease in pain intensity of 81.5% was observed associated with a significant reduction in analgesic intake. Improvements in disability (91.3% decrease in ODI score and in quality of life (increase 21.1% of EQ-VAS score were obtained 3 months after surgery. All results were maintained at 12 months. A reduction in the kyphotic angulation was observed postoperatively (-5.4±6.3°; p<0.001, remained at 12 months (-4.4±6.0°, p=0.002. No adverse events were implant-related and none required device removal. Three patients (2.9% experienced procedure-related complications. The overall adjacent fracture rate up to 1 year after surgery was 2.9%. The SpineJack procedure is an effective, low-risk procedure for patients with traumatic VCF allowing a fast and sustained improvement in quality of life over 1 year after surgery.

  16. Plasmodium vivax sub-patent infections after radical treatment are common in Peruvian patients: results of a 1-year prospective cohort study.

    Directory of Open Access Journals (Sweden)

    Peter Van den Eede

    Full Text Available BACKGROUND: There is an increasing body of literature reporting treatment failure of the currently recommended radical treatment of Plasmodium vivax infections. As P. vivax is the main malaria species outside the African continent, emerging tolerance to its radical treatment regime could have major consequences in countries like Peru, where 80% of malaria cases are due to P. vivax. Here we describe the results of a 1-year longitudinal follow up of 51 confirmed P. vivax patients living around Iquitos, Peruvian Amazon, and treated according to the Peruvian national guidelines. METHODOLOGY: Each month a blood sample for microscopy and later genotyping was systematically collected. Recent exposure to infection was estimated by detecting antibodies against the P. vivax circumsporozoite protein (CSP and all PCR confirmed P. vivax infections were genotyped with 16 polymorphic microsatellites. RESULTS: During a 1-year period, 84 recurrent infections, 22 positive also by microscopy, were identified, with a median survival time to first recurrent infection of 203 days. Most of them (71% were asymptomatic; in 13 patients the infection persisted undetected by microscopy for several consecutive months. The genotype of mostly recurrent infections differed from that at day 0 while fewer differences were seen between the recurrent infections. The average expected heterozygosity was 0.56. There was strong linkage disequilibrium (I(A(s = 0.29, p<1.10(-4 that remained also when analyzing only the unique haplotypes, suggesting common inbreeding. CONCLUSION: In Peru, the P. vivax recurrent infections were common and displayed a high turnover of parasite genotypes compared to day 0. Plasmodium vivax patients, even when treated according to the national guidelines, may still represent an important parasite reservoir that can maintain transmission. Any elimination effort should consider such a hidden reservoir.

  17. University Extra-Mural Studies and Extension Outreach: Incompatibilities

    Science.gov (United States)

    Rogers, Alan

    2014-01-01

    The argument of this paper is that--within a wide range of university responses to the challenge of outreach--there grew up in the extra-mural or adult education departments of many UK universities an alternative epistemological paradigm to the older and more traditional extension programmes. This paradigm threatened the extension approach and has…

  18. Medical students who decompress during the M-1 year outperform those who fail and repeat it: A study of M-1 students at the University of Illinois College of Medicine at Urbana-Champaign 1988–2000

    Directory of Open Access Journals (Sweden)

    Freund Gregory G

    2005-05-01

    Full Text Available Abstract Background All medical schools must counsel poor-performing students, address their problems and assist them in developing into competent physicians. The objective of this study was to determine whether students with academic deficiencies in their M-1 year graduate more often, spend less time to complete the curriculum, and need fewer attempts at passing USMLE Step 1 and Step 2 by entering the Decompressed Program prior to failure of the M-1 year than those students who fail the M-1 year and then repeat it. Method The authors reviewed the performance of M-1 students in the Decompressed Program and compared their outcomes to M-1 students who failed and fully repeated the M-1 year. To compare the groups upon admission, t-Tests comparing the Cognitive Index of students and MCAT scores from both groups were performed. Performance of the two groups after matriculation was also analyzed. Results Decompressed students were 2.1 times more likely to graduate. Decompressed students were 2.5 times more likely to pass USMLE Step 1 on the first attempt than the repeat students. In addition, 46% of those in the decompressed group completed the program in five years compared to 18% of the repeat group. Conclusion Medical students who decompress their M-1 year prior to M-1 year failure outperform those who fail their first year and then repeat it. These findings indicate the need for careful monitoring of M-1 student performance and early intervention and counseling of struggling students.

  19. Study on gene sensor based on primer extension

    Institute of Scientific and Technical Information of China (English)

    陈誉华; 宋今丹; 李大为

    1997-01-01

    Based on the fact that the resonant frequency of a piezoelectric crystal is the function of its surface deposit, and that the primer extends after it hybridizes with the template, the primer extension gene sensor technique was developed. The prominent feature of the technique is that fast and sensitive frequency signals are used as the monitoring system of gene hybridization and primer strand extension. Results show that this technique may be used in homologous analysis of nucleic acid, trace DNA detection, and determining the integration of DNA. It may also be used for isolation of target gene, gene mutation analysis, and predicting the location of a gene in its genome.

  20. Extension Master Gardener Social Media Needs: A National Study

    Science.gov (United States)

    Vines, Karen A.; Jeannette, Karen; Eubanks, Emily; Lawrence, Maggie; Radhakrishna, Rama

    2016-01-01

    An online survey was conducted to assess the feasibility of providing training on the use of social media for the Extension Master Gardener (EMG) program. Volunteers (n = 1,275) and coordinators (n = 111) responded. Findings indicate the existence of sufficient interest in a nationally coordinated social media training. Inclusion of social media…

  1. An Extension Case Study in Institutional Innovation: Microfinance Intermediary Formation

    Science.gov (United States)

    Edelman, Mark A.

    2015-01-01

    An institutional innovation process led by Extension created a statewide microfinance intermediary. The intermediary provides business technical assistance and microloans to entrepreneurs having difficulty securing conventional credit but having workable business plans. The process included (1) gathering indicators of a problem; (2) formation of a…

  2. Choking - adult or child over 1 year

    Science.gov (United States)

    Abdominal thrusts - adult or child over 1 year; Heimlich maneuver - adult or child over 1 year: Choking - back ... back blows, or both. To perform abdominal thrusts (Heimlich maneuver): Stand behind the person and wrap your arms ...

  3. MVPA Is Associated with Lower Weight Gain in 8–10 Year Old Children: A Prospective Study with 1 Year Follow-Up

    OpenAIRE

    Abigail Fisher; Claire Hill; Laura Webber; Lisa Purslow; Jane Wardle

    2011-01-01

    BACKGROUND: Studies relating physical activity (PA) to weight gain in children have produced mixed results, although there is some evidence for stronger associations with more intense physical activities. The present study tested the hypothesis that weight gain over one year in 8-10 year olds would be more strongly predicted by moderate and vigorous physical activity (MVPA) than total physical activity (total PA) or sedentary behaviour. METHODOLOGY: Participants were 280 children taking part ...

  4. Buccal bone thickness at dental implants in the aesthetic zone : A 1-year follow-up cone beam computed tomography study

    NARCIS (Netherlands)

    Slagter, Kirsten W.; Raghoebar, Gerry M.; Bakker, Nicolaas A.; Vissink, Arjan; Meijer, Henny J. A.

    2017-01-01

    Sufficient buccal bone thickness (BBT) is important for an optimal aesthetic outcome of implant treatment in the aesthetic zone. The aim of the study was to assess BBT at dental implants placed in the aesthetic zone (incisor, canine or first premolar in the maxilla) (immediate or delayed, with or wi

  5. Associations of Work-Related Factors and Work Engagement with Mental and Physical Health: A 1-Year Follow-up Study Among Older Workers

    NARCIS (Netherlands)

    Leijten, F.R.M.; Heuvel, S.G. van den; Beek, A.J. van der; Ybema, J.F.; Robroek, S.J.W.; Burdorf, A.

    2015-01-01

    Purpose The goals of this study were to determine whether, among older employees, unfavourable physical and psychosocial work-related factors were associated with poorer mental and physical health and whether high work engagement buffered the associations between unfavourable work-related factors an

  6. Associations of Work-Related Factors and Work Engagement with Mental and Physical Health : A 1-Year Follow-up Study Among Older Workers

    NARCIS (Netherlands)

    Leijten, Fenna R M; van den Heuvel, Swenne G.; van der Beek, Allard J.; Ybema, Jan Fekke; Robroek, Suzan J W; Burdorf, Alex

    2015-01-01

    Purpose The goals of this study were to determine whether, among older employees, unfavourable physical and psychosocial work-related factors were associated with poorer mental and physical health and whether high work engagement buffered the associations between unfavourable work-related factors an

  7. The relationship between low back pain and leisure time physical activity in a working population of cleaners - a study with weekly follow-ups for 1 year

    DEFF Research Database (Denmark)

    Jespersen, Tobias; Jorgensen, Marie B; Hansen, Jorgen V

    2012-01-01

    intensity in the subsequent 4 weeks. METHODS: 188 cleaners consented to participate in a 52-week text message survey about hours of LTPA and intensity of LBP (from 0 to 9) over the previous 7 days. The correlation between LBP and LTPA was calculated by Pearson correlation coefficient. During an episode...... on studies involving patient populations. The purpose of the study was (1) to investigate the correlation between LBP and LTPA on a weekly basis over the course of a year in a high-risk group of cleaners; and (2) to investigate if maintaining LTPA during an episode of acute LBP has a positive effect on LBP......: The correlation between weekly LTPA and LBP data was negative, but numerically low (r = 0.069) and statistically insignificant (p = 0.08). Among the 82 cleaners experiencing at least one episode of acute LBP, those maintaining LTPA during an episode of acute LBP did not have a lower pain intensity (average LBP...

  8. Using self-efficacy theory to educate a patient with chronic obstructive pulmonary disease: A case study of 1-year follow-up.

    Science.gov (United States)

    Kaşıkçı, Magfiret K

    2011-02-01

    Self-efficacy is important in determining which activities or situations an individual will perform or avoid. This is a case study report to explore the utility of structured education programme on strengthening self-efficacy in an older adult with chronic obstructive pulmonary disease (COPD). To comprehensively evaluate this intervention, a combined qualitative and quantitative approach was used. Although qualitative data were collected following the interview guide, quantitative data were collected by the demographic data form and the COPD Self-Efficacy Scale (CSES) at the preprogramme and postprogramme stage. The patient's self-efficacy scores improved after 8 weeks of the structured education programme and remained relatively constant on all the repeated measurements after education. Qualitative data were identified as 'difficulties' and 'facilities'. This study indicates that, by applying a self-efficacy theory, a planned education programme could be useful in improving both short-term and long-term self-efficacy in patients with COPD.

  9. [Comparative study of 3 drugs (aceglutamide aluminum, zinc acexamate, and magaldrate) in the long-term maintenance treatment (1 year) of peptic ulcer].

    Science.gov (United States)

    Varas Lorenzo, M J; López Martínez, A; Gordillo Bernal, J; Mundet Surroca, J

    1991-08-01

    In a multicentre study, 146 peptic ulcer patients who had recently healed with H2 antagonists (38 gastric, 108 duodenal ulcers) received randomly for a year one of the following mucosal protecting antiulcer drugs: aceglutamide aluminium salt (AAL), zinc acexamate (ZAC) and magaldrate (MAG). Forty six patients received AAL (700 mg bid), 50 patients received ZAC (300 mg at single nocturnal dose) and 50 patients received MAG (800 mg bid). An endoscopic examination was performed at the beginning of the study and 12 months later. Clinical examinations where performed on months 3, 6 and 9, advancing the endoscopical control in case of ulcer symptoms. ZAC showed to be superior to MAG (p less than 0.05, chi-square test) in preventing relapses, with a favourable tendence in front of AAL, but without reaching statistical significance. Its important to mention the high number of withdrawals and the good tolerance of the treatments.

  10. MVPA is associated with lower weight gain in 8-10 year old children: a prospective study with 1 year follow-up.

    Directory of Open Access Journals (Sweden)

    Abigail Fisher

    Full Text Available BACKGROUND: Studies relating physical activity (PA to weight gain in children have produced mixed results, although there is some evidence for stronger associations with more intense physical activities. The present study tested the hypothesis that weight gain over one year in 8-10 year olds would be more strongly predicted by moderate and vigorous physical activity (MVPA than total physical activity (total PA or sedentary behaviour. METHODOLOGY: Participants were 280 children taking part in the Physical Exercise and Appetite in Children Study (PEACHES. Weight status was assessed using body mass index (BMI, fat mass index (FMI, and waist circumference (WC in school Year 4 (baseline; age 8.7 yrs and Year 5 (follow-up; age 9.7 yrs. Physical activity was measured at baseline using the Actigraph GT1M accelerometer to assess total PA (mean accelerometers counts per minute, MVPA; ≥ 4000 counts per minute and sedentary time (<100 counts per minute. PRINCIPAL FINDINGS: After adjustment for baseline BMI, SES, sex and ethnicity, MVPA was significantly associated with follow-up BMI (adjusted β  = -0.07; p = 0.002. This association was independent of total PA or sedentary time. Similar results were observed for FMI; again MVPA was significantly associated with follow up FMI (β = -0.16; p = 0.001 independent of total PA or sedentary time. The pattern was similar for WC (β = -0.07, but the association between MVPA and WC did not reach significance at p = 0.06. CONCLUSION: The results of this study strongly support promotion of MVPA in children.

  11. Quality of life among patients undergoing bariatric surgery: associations with mental health- A 1 year follow-up study of bariatric surgery patients

    Directory of Open Access Journals (Sweden)

    Stubhaug Bjarte

    2011-09-01

    Full Text Available Abstract Background Preoperative mental health seems to have useful predictive value for Health Related Quality of Life (HRQOL after bariatric surgery. The aim of the present study was to assess pre- and postoperative psychiatric disorders and their associations with pre- and postoperative HRQOL. Method Data were assessed before (n = 127 and one year after surgery (n = 87. Psychiatric disorders were assessed by Mini International Neuropsychiatric Interview (M.I.N.I. and Structured Clinical Interview (SCID-II. HRQOL was assessed by the Short Form 36 (SF-36 questionnaire. Results Significant improvements were found in HRQOL from preoperative assessment to follow-up one year after surgery. For the total study population, the degree of improvement was statistically significant (p values Conclusion This study reports the novel finding that patients without postoperative psychiatric disorders achieved a HRQOL comparable to the general population one year after bariatric surgery; while patients with postoperative psychiatric disorders did not reach the HRQOL level of the general population. Our results support monitoring patients with psychiatric disorders persisting after surgery for suboptimal improvements in quality of life after bariatric surgery. Trial Registration The trial is registered at http://www.clinicaltrials.gov prior to patient inclusion (ProtocolID16280.

  12. Depression in relation to anxiety, obsessionality and phobia among neurosurgical patients with a primary brain tumor: a 1-year follow-up study.

    Science.gov (United States)

    Mainio, Arja; Hakko, Helinä; Niemelä, Asko; Koivukangas, John; Räsänen, Pirkko

    2011-10-01

    Depression is found to be present in up to 44% of brain tumor patients during their illness process. Anxiety as a comorbid psychiatric disorder with depression has formerly been studied, but phobia or obsessive-compulsive symptoms among brain tumor patients have not yet been noticed. By using a clinical prospective database of primary brain tumor patients (n=77) we studied the level of depression, anxiety, obsessionality (traits and symptoms) and phobic anxiety symptoms. Psychiatric symptoms were assessed before tumor operation as well as at three months and at one year after operation. The presence of comorbid anxiety, obsessionality and phobic anxiety symptoms was assessed before operation and at follow-ups in depressed and non-depressed patients, separately. Before tumor operation 16% of the patients had depression according to Beck Depression Inventory (BDI), while 10% had depression at three months and 15% at one year after operation. The depressed patients had statistically significantly higher anxiety scores and phobic scores at all three measurement points compared to corresponding scores among non-depressed brain tumor patients. The mean obsessionality scores among depressed brain tumor patients were significantly higher when measured before operation and at one year after the operation compared to non-depressed patients. To our knowledge, this is the first study so far in which comorbidity of psychiatric symptoms has been shown among depressive brain tumor patients. Concurrent comorbid conditions have been shown to be associated with increased severity, morbidity and chronicity of depression. It is recommended that treatment of depressive patients complicated with comorbid psychiatric disorders be planned by psychiatric units.

  13. The Health Initiative Program for Kids (HIP Kids): effects of a 1-year multidisciplinary lifestyle intervention on adiposity and quality of life in obese children and adolescents - a longitudinal pilot intervention study

    OpenAIRE

    Bock, Dirk E; Robinson, Tracy; Seabrook, Jamie A; Rombeek, Meghan; Norozi, Kambiz; Filler, Guido; Rauch, Ralf; Clarson, Cheril L

    2014-01-01

    Background Though recent data suggest that multidisciplinary outpatient interventions can have a positive effect on childhood obesity, it is still unclear which program components are most beneficial and how they affect quality of life (QoL). The aim of this study was to determine if a 1-year multidisciplinary, family-centered outpatient intervention based on social cognitive theory would be effective in (i) preventing further increases in BMI and BMI z-score, and (ii) improving QoL in obese ...

  14. Intra-articular hyaluronan is without clinical effect in knee osteoarthritis: a multicentre, randomised, placebo-controlled, double-blind study of 337 patients followed for 1 year

    DEFF Research Database (Denmark)

    Jørgensen, Anette; Stengaard-Pedersen, Kristian; Simonsen, Lars Ole;

    2010-01-01

    Objective To examine the long-term efficacy and safety of five intra-articular injections with hyaluronan in knee osteoarthritis. Methods A multicentre, randomised, placebo-controlled double-blind study of 337 patients fulfilling the American College of Rheumatology (ACR) criteria for knee...... efficacy parameter. LFI, pain on walking 50 m based on visual analogue scale (VAS pain 50 m), paracetamol consumption, patients' global assessment, Nottingham health profile, joint effusion and number of responders were secondary efficacy parameters. The efficacy parameters were analysed by intention...... to treat (ITT) and per protocol (PP). All adverse events (AE) were recorded as safety parameters. Results Time to recurrence showed no significant treatment effect (ITT analysis, p = 0.26). Change from baseline in LFI and VAS pain 50 m for the ITT population showed no treatment effect. Paracetamol...

  15. Coping behaviour of extension agents in role conflict situations: a case study in Xinji county, China

    OpenAIRE

    Huang, R.Q.

    1998-01-01

    This book is about the coping behaviour of extension agents in role conflict situations in a changing environment in China. The study presents the case of cotton production in Xinji county, China.Chapter 1 gives background information on Chinese agricultural and rural reform since 1978 and its impact for extension system and extension agents. Before the rural reform, Chinese agriculture was collectively managed. The extension system dealt with collective groups of farmers and was used as a po...

  16. Posterior muscle chain activity during various extension exercises: an observational study

    OpenAIRE

    De Ridder, Eline MD; Oosterwijck, Jessica O; Vleeming, Andry; Vanderstraeten, Guy G.; Danneels, Lieven A

    2013-01-01

    Background: Back extension exercises are often used in the rehabilitation of low back pain. However, at present it is not clear how the posterior muscles are recruited during different types of extension exercises. Therefore, the present study will evaluate the myoelectric activity of thoracic, lumbar and hip extensor muscles during different extension exercises in healthy persons. Based on these physiological observations we will make recommendations regarding the use of extensions exercises...

  17. Effect of neck strength training on health-related quality of life in females with chronic neck pain: a randomized controlled 1-year follow-up study

    Directory of Open Access Journals (Sweden)

    Kautiainen Hannu

    2010-05-01

    Full Text Available Abstract Background Chronic neck pain is a common condition associated not only with a decrease in neck muscle strength, but also with decrease in health-related quality of life (HRQoL. While neck strength training has been shown to be effective in improving neck muscle strength and reducing neck pain, HRQoL among patients with neck pain has been reported as an outcome in only two short-term exercise intervention studies. Thus, reports on the influence of a long-term neck strength training intervention on HRQoL among patients with chronic neck pain have been lacking. This study reports the effect of one-year neck strength training on HRQoL in females with chronic neck pain. Methods One hundred eighty female office workers, 25 to 53 years of age, with chronic neck pain were randomized to a strength training group (STG, n = 60, endurance training group (ETG, n = 60 or control group (CG, n = 60. The STG performed high-intensity isometric neck strengthening exercises with an elastic band while the ETG performed lighter dynamic neck muscle training. The CG received a single session of guidance on stretching exercises. HRQoL was assessed using the generic 15D questionnaire at baseline and after 12 months. Statistical comparisons among the groups were performed using bootstrap-type analysis of covariance (ANCOVA with baseline values as covariates. Effect sizes were calculated using the Cohen method for paired samples. Results Training led to statistically significant improvement in the 15D total scores for both training groups, whereas no changes occurred for the control group (P = 0.012, between groups. The STG improved significantly in five of 15 dimensions, while the ETG improved significantly in two dimensions. Effect size (and 95% confidence intervals for the 15D total score was 0.39 (0.13 to 0.72 for the STG, 0.37 (0.08 to 0.67 for the ETG, and -0.06 (-0.25 to 0.15 for the CG. Conclusions One year of either strength or endurance training seemed

  18. The relationship between low back pain and leisure time physical activity in a working population of cleaners - a study with weekly follow-ups for 1 year

    Directory of Open Access Journals (Sweden)

    Jespersen Tobias

    2012-02-01

    Full Text Available Abstract Background Low back pain (LBP and leisure time physical activity (LTPA are considered to be closely related, and clinical guidelines for the treatment of acute LBP recommend patients stay physically active. However, the documentation for this recommendation is sparse and based on studies involving patient populations. The purpose of the study was (1 to investigate the correlation between LBP and LTPA on a weekly basis over the course of a year in a high-risk group of cleaners; and (2 to investigate if maintaining LTPA during an episode of acute LBP has a positive effect on LBP intensity in the subsequent 4 weeks. Methods 188 cleaners consented to participate in a 52-week text message survey about hours of LTPA and intensity of LBP (from 0 to 9 over the previous 7 days. The correlation between LBP and LTPA was calculated by Pearson correlation coefficient. During an episode of acute LBP, a mixed effect logistic regression model was used to investigate whether cleaners who maintain LTPA have a lower pain intensity and higher probability of returning to initial pain intensity within the following four weeks compared with cleaners who decrease LTPA during acute LBP. Results The correlation between weekly LTPA and LBP data was negative, but numerically low (r = -0.069 and statistically insignificant (p = 0.08. Among the 82 cleaners experiencing at least one episode of acute LBP, those maintaining LTPA during an episode of acute LBP did not have a lower pain intensity (average LBP intensity difference between groups of 0.06; 95% confidence interval (95% CI of -0.417 to 0.539 or higher probability of returning to initial pain level (Odds ratio 1,02; 95% CI of 0.50 to 2.09 in the following four weeks compared with cleaners decreasing LTPA during acute LBP. Conclusions Hours of LTPA and intensity of LBP measured on a weekly basis throughout a year showed no close correlation. Maintaining LTPA during an episode of acute LBP did not result in a

  19. A prospective study of treatment patterns and 1-year outcome of Asian age-related macular degeneration and polypoidal choroidal vasculopathy.

    Directory of Open Access Journals (Sweden)

    Chui Ming Gemmy Cheung

    Full Text Available OBJECTIVE: To study the treatment patterns and visual outcome over one year in Asian patients with choroidal neovascular membrane secondary to age-related macular degeneration (AMD-CNV and polypoidal choroidal vasculopathy (PCV. DESIGN: Prospective cohort, non-interventional study. METHODS: 132 treatment-naïve patients who received treatment for AMD-CNV and PCV were included. All patients underwent standardized examination procedures including retinal imaging at baseline and follow-up. AMD-CNV and PCV were defined on fundus fluorescein angiography and indocyanine green angiography at baseline. Patients were treated according to standard of care.We report the visual acuity (VA and optical coherence tomography (OCT measurements at baseline, month 3 and month 12 The factors influencing month 12 outcomes were analyzed. MAIN OUTCOME MEASURE: Type of treatment, number of Anti-vascular endothelial growth factor (VEGF treatments, visual outcome over one year. RESULTS: Anti-VEGF monotherapy was the initial treatment in 89.1% of AMD-CNV, but only 15.1% of PCV. The mean number of anti-VEGF injections up to month 12 was 3.97 (4.51 AMD-CNV, 3.43 PCV, p = 0.021. Baseline OCT, month 3 OCT and month 3 VA were significant in determining continuation of treatment after month 3. At month 12, mean VA improved from 0.82 (∼20/132 at baseline to 0.68 (∼20/96 at month 12 (mean gain 6.5 ETDRS letters, p = 0.002. 34.2% of eyes (38/113 eyes gained ≥15 ETDRS letters and 14.4% (16/113 eyes lost ≥15 ETDRS letters. There were no significant differences in visual outcome between AMD-CNV and PCV (p = 0.51. Factors predictive of month 12 visual outcome were baseline VA, baseline OCT central macular thickness, month 3 VA and age. CONCLUSIONS: There is significant variation in treatment patterns in Asian eyes with exudative maculopathy. There is significant visual improvement in all treatment groups at one year. These data highlight the need for high quality

  20. Study of factors responsible for recurrence of seizures in controlled epileptics for more than 1 years after withdrawal of antiepileptic drugs.

    Directory of Open Access Journals (Sweden)

    Lamdhade S

    2002-07-01

    Full Text Available 531 epileptic patients, who had achieved remission mostly for 2 years or more were studied. The mean follow up period was 5 years. Recurrence was noted in 103 patients (19% after gradual withdrawal of AED, over a period of 3-4 months. 424 patients (81% did not have recurrence. The recurrence rate was influenced adversely by factors like adolescent age and later onset seizures, pre-treatment duration of symptoms more than 3 years, pre-treatment precipitating factors like emotional stress, lack of sleep and meals (however, number in each group is small, positive family history of epilepsy, focal neurodeficit, absence and myoclonic plus grandmal type of clinical seizures, paroxysmal generalized spike and wave discharges and generalized short polyspike and wave discharges in the pretreatment EEG, atrophic changes on CT brain scan (in small numbers, head trauma at birth or later and hereditary factors as etiology of epilepsy, and more than 30 number of seizures before achieving the remission. Factors like, sex, frequency of seizures, period of remission i.e. two years or more and number of drugs used to achieve remission, did not have any significant adverse effect. However, in the last parameter 95% remission was achieved by one or a combination of two drugs (72% and 23% respectively.

  1. Marine n-3 polyunsaturated fatty acids affect the blood pressure control in patients with newly diagnosed hypertension - a 1-year follow-up study.

    Science.gov (United States)

    Bagge, Carina N; Strandhave, Charlotte; Skov, Charlotte M; Svensson, My; Schmidt, Erik B; Christensen, Jeppe H

    2017-02-28

    Marine long-chained n-3 polyunsaturated fatty acids (PUFA) are recognized for their cardio-protective effects, including potential lowering of blood pressure. We hypothesized that higher habitual fish intake and n-3 PUFA plasma levels were associated with lower blood pressure and being less likely to receive antihypertensive medication after one-year follow-up. In this prospective study of 115 patients, we assessed 24 h ambulatory and central blood pressure, plasma phospholipid fatty acid composition using gas chromatography and participants completed a food frequency questionnaire, including fish-eating habits. All measurements were repeated at one-year follow-up. At baseline, patients consuming fish ≥2 times per month for dinner had significantly higher plasma levels of total marine n-3 PUFA, docosahexaenoic acid and eicosapentaenoic acid as well as significantly lower central blood pressure and a trend towards lower peripheral blood pressure. At follow-up, 21 patients (18%) without antihypertensive medication had significantly higher plasma levels of n-3 PUFA, docosahexaenoic acid and eicosapentaenoic acid as well as a higher, but still acceptable 24 h ambulatory blood pressure (137/85 mmHg) compared to subjects receiving antihypertensive medication. The untreated group was more prone to take fish oil capsules and increased their plasma levels of n-3 PUFA compared to baseline. In patients with newly diagnosed, untreated hypertension, regular fish consumption was accompanied by lower blood pressure. After one year, patients without antihypertensive medication were characterized by a significant increase and higher plasma levels of n-3 PUFA. This supports a blood pressure-lowering effect and suggests an increase in marine n-3 PUFA intake as part of non-pharmacological treatment of hypertension.

  2. Deep Brain Stimulation of the Globus Pallidus Internus in Patients with Intractable Tourette Syndrome: A 1-year Follow-up Study

    Institute of Scientific and Technical Information of China (English)

    Xiao-Hua Zhang; Jian-Yu Li; Yu-Qing Zhang; Yong-Jie Li

    2016-01-01

    Background:Deep brain stimulation (DBS) has been a promising treatment for patients with refractory Tourette syndrome (TS) for more than a decade.Despite successful DBS treatment of TS in more than 100 patients worldwide,studies with a large patient sample and long-term follow-up assessments are still scarce.Accordingly,we investigated the clinical efficacy and safety of globus pallidus internus (GPi) DBS in the treatment of intractable TS in 24 patients with a l-year follow-up assessment.Methods:Bilateral/unilateral GPi-DBS was performed in 24 patients with TS.We evaluated symptoms of tics and obsessive-compulsive disorder (OCD) through the Yale Global Tic Severity Scale (YGTSS) and Yale-Brown Obsessive-compulsive Scale (Y-BOCS).We used the Wechsler Adult Intelligence Scale-Revised in China (WAIS-RC) to evaluate the safety of the treatment.We conducted follow-up assessments of all patients for at least 12 months (12-99 months).Results:Symptoms of tics and OCD were significantly relieved at a 12-month follow-up assessment.The mean YGTSS score was 74.04 ± 11.52,49.83 ± 10.91,32.58 ± 7.97,and 31.21 ± 8.87 at baseline,3,6,and 12 months,respectively.The mean YGTSS scores obtained at the follow-up assessments were significantly different from the baseline (P < 0.05).The improvement in motor tics was superior to that in phonic tics.The mean Y-BOCS scores were 21.61 ± 4.97,18 ± 4.58,14.39 ± 3.99,and 13.78 ± 4.56 at baseline,3,6,and 12 months,respectively (P < 0.05).We observed a remarkable improvement in psychiatric comorbidities,such as OCD and attention-deficit hyperactivity disorder,after the procedure.WAIS-RC scores were comparable before and after the operation.There were no severe postoperative complications.Conclusion:GPi-DBS appears to comprehensively alleviate tic symptoms and psychiatric comorbidities in patients with TS,thus significantly improving patients' quality of life.

  3. Facial fractures: a 1-year retrospective study in a hospital in Belo Horizonte Fraturas de face: um estudo retrospectivo de 1 ano em um hospital de Belo Horizonte

    Directory of Open Access Journals (Sweden)

    Bruno Ramos Chrcanovic

    2004-12-01

    Full Text Available A retrospective study was performed to assess facial fractures in patients treated at a public hospital in Belo Horizonte, in 2000. The data collected included age, gender, etiology, distribution of maxillofacial trauma considering day of the week and month, anatomic site of the fracture, and treatment. The analyses involved descriptive statistics and chi-squared test, Bonferroni test and analysis of variance. A total of 1,326 facial fractures were found in 911 patients. Most fractures occurred in adults with age ranging from 21 to 30 years. Men were more affected than women, with a male-female ratio of 4.69:1. Accidents causing facial fractures occurred predominantly on weekends. Bicycle and motorcycle accidents were the major cause of trauma, followed by interpersonal violence, automobile accidents, and falls. When the relation between the gender and the etiology of facial fractures was analyzed, a significant relation was noted between these variables (p Um estudo retrospectivo foi realizado para avaliar fraturas faciais em pacientes atendidos no ano de 2000 em um hospital público de Belo Horizonte. As informações coletadas incluíam idade, sexo, etiologia, distribuição do trauma de acordo com o dia da semana e o mês, o local anatômico da fratura e o tratamento. As análises envolveram estatísticas descritivas, teste qui-quadrado, teste Bonferroni e análise de variância. Foram encontradas 1.326 fraturas de face em 911 pacientes. A maioria das fraturas ocorreu em adultos na faixa etária de 21 a 30 anos. Os homens foram mais acometidos do que as mulheres, numa proporção homem:mulher de 4,69:1. Os traumas causadores de fraturas faciais ocorreram predominantemente nos fins de semana. Os acidentes de moto e bicicleta foram a maior causa de trauma, seguidos por violência interpessoal, acidentes automobilísticos e quedas. Quando analisada a relação entre o gênero e a etiologia das fraturas de face, observou-se uma associa

  4. Predictors of short- and long-term outcome in patients with chronic non-specific neck pain undergoing an exercise-based rehabilitation program: a prospective cohort study with 1-year follow-up.

    Science.gov (United States)

    Cecchi, Francesca; Molino-Lova, Raffaele; Paperini, Anita; Boni, Roberta; Castagnoli, Chiara; Gentile, Jacopo; Pasquini, Guido; Macchi, Claudio

    2011-10-01

    The aim of this study was to describe the clinical course of patients with chronic, non-specific neck pain undergoing a public health covered, exercise-based rehabilitation program and to identify predictors of poor outcome. A prospective cohort study was carried out on patients with non-specific neck pain (6 months or longer), referred by their general practitioner to a 6-session program, including education and individually tailored exercise. The primary outcome measure for the course of neck pain was the Northwick neck pain questionnaire (NPQ) administered on baseline, discharge, and 1 year from discharge. Poor outcome was defined as NPQ score improving neck pain history, and the clinical features described by NPQ. From January 2008 to June 2009, 212 patients were consecutively assessed for eligibility: 178 were enrolled and 162 completed follow-up (mean age = 65.3; 75% women). Baseline NPQ average score (40.7 + 17.1) improved by MCID on discharge (26.1 + 16.3) and at 1 year (28.5 + 17.3%). The poor outcome was reported by 45% patients on discharge and by 56% at follow-up. Pain-related medication intake independently predicted poor short- (OR 4.24; 95% CI 1.83-9.84; p = 0.001) and long-term (OR 2.69; 95% CI 1.19-6.06; p = 0.017) outcome, and catastrophizing (OR 2.91; 95% CI 1.31-6.48; p = 0.009) predicted poor outcome at 1 year. Our cohort of patients with chronic neck pain undergoing an exercise-based rehabilitation program reported improvement by or beyond MICD-NPQ in 55% cases on discharge and in 44% cases at 1 year. Poor outcome was predicted by pain-related medication intake in the short and long term, and by catastrophizing in the long term.

  5. Baseline Serum Osteopontin Levels Predict the Clinical Effectiveness of Tocilizumab but Not Infliximab in Biologic-Naive Patients with Rheumatoid Arthritis: A Single-Center Prospective Study at 1 Year (the Keio First-Bio Cohort Study.

    Directory of Open Access Journals (Sweden)

    Keisuke Izumi

    Full Text Available To explore the baseline predictors of clinical effectiveness after tocilizumab or infliximab treatment in biologic-naïve rheumatoid arthritis patients.Consecutive biologic-naïve patients with rheumatoid arthritis initiating infliximab (n = 57 or tocilizumab (n = 70 treatment were included in our prospective cohort study. Our cohort started in February 2010, and the patients observed for at least 1 year as of April 2013 were analysed. We assessed baseline variables including patients' characteristics (age, sex, disease duration, prednisolone dose, methotrexate dose, other disease-modifying antirheumatic drug use, Clinical Disease Activity Index [CDAI] and serum biomarker levels (C-reactive protein, immunoglobulin M-rheumatoid factor, anti-cyclic citrullinated protein/peptide antibodies, interferon-γ, interleukin (IL-1β, IL-2, IL-6, IL-8, IL-10, IL-17, tumor necrosis factor-α, soluble intercellular adhesion molecule-1, bone alkaline phosphatase, osteonectin, osteopontin to extract factors associated with clinical remission (CDAI ≤ 2.8 at 1 year using univariate analyses, and the extracted factors were entered into a multivariate logistic regression model. Similar analyses were also performed for Simplified Disease Activity Index (SDAI remission (≤ 3.3 and Disease Activity Score with 28 joint counts, erythrocyte sedimentation rate (DAS28-ESR remission (< 2.6.There were no significant differences in the baseline characteristics except for methotrexate use between the groups. In the multivariate analyses, the low baseline osteopontin levels (OR 0.9145, 95% CI 0.8399-0.9857 were identified as predictors of CDAI remission in the tocilizumab group, whereas no predictors of CDAI remission were found in the infliximab group. Similar results were obtained when using SDAI and DAS28-ESR remission criteria.Baseline low serum osteopontin levels predict clinical remission 1 year after tocilizumab treatment and not infliximab treatment in biologic

  6. Handgrip strength, quadriceps muscle power, and optimal shortening velocity roles in maintaining functional abilities in older adults living in a long-term care home: a 1-year follow-up study

    Directory of Open Access Journals (Sweden)

    Kozicka I

    2016-05-01

    Full Text Available Izabela Kozicka, Tomasz Kostka Department of Geriatrics, Medical University of Lodz, Lodz, Poland Purpose: To assess the relative role of handgrip strength (HGS, quadriceps muscle power (Pmax, and optimal shortening velocity (υopt in maintaining functional abilities (FAs in older adults living in a long-term care home over a 1-year follow-up. Subjects and methods: Forty-one inactive older institutionalized adults aged 69.8±9.0 years participated in this study. HGS, Pmax, υopt, cognitive function using the Mini-Mental State Examination, depressive symptoms using the Geriatric Depression Scale, nutritional status using the Mini Nutritional Assessment (MNA, and physical activity (PA using the Seven-Day Physical Activity Recall Questionnaire were assessed at baseline and at 1-year follow-up. FAs were assessed with activities of daily living (ADL, instrumental ADL, and Timed Up & Go test. Results: Both at baseline and at follow-up, FAs were related to age, HGS, Pmax/kg, υopt, MNA, and PA. These associations were generally similar in both sexes. As revealed in multiple regression analysis, υopt was the strongest predictor of FA, followed by Pmax/kg, PA, and MNA. FA deteriorated after 1 year as measured by ADL and Timed Up & Go test. Pmax and υopt, but not HGS, also decreased significantly after 1 year. Nevertheless, 1-year changes in FAs were not related to changes in HGS, Pmax, υopt, or PA. Conclusion: The 1-year period of physical inactivity among older institutionalized adults was found to have a negative effect on their FAs, Pmax, and υopt. The present study demonstrates that Pmax and, especially, υopt correlated with FAs of older adults more than HGS, both at baseline and at follow-up. Despite this, 1-year natural fluctuations of PA, Pmax, and υopt are not significant enough to influence FAs in inactive institutionalized older adults. Keywords: aging, handgrip strength, institutionalization, functional status, physical activity

  7. Vocabulary Learning through Extensive Reading: A Case Study

    Science.gov (United States)

    Senoo, Yasuko; Yonemoto, Kazuhiro

    2014-01-01

    The role and importance of reading in second language vocabulary learning have been discussed by many researchers because of the richness and variety of vocabulary in written texts compared to oral discourse (Horst, 2005; Nation, 2001). However, despite the recent increase of studies in this field, there are very few studies focusing on…

  8. Extensive HLA class Ⅱ studies in Chinese narcoleptic patients.

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    Objective: Narcolepsy is a debilitating, lifelong sleep disorder. Its familial occurrence suggests that genetic factors may be of importance in the etiology. Narcolepsy is a very rare disease among Chinese, thus it was of interest to study the association of narcolepsy with the HLA system in Chinese narcoleptic patients.

  9. Your Child's Development: 1 Year (12 Months)

    Science.gov (United States)

    ... Kids For Parents MORE ON THIS TOPIC Your Child's Checkup: 1 Year (12 Months) Your Baby's Growth: 12 Months Your Baby's Hearing, Vision, and Other Senses: 12 Months Sleep and Your 8- to 12-Month-Old Growth ...

  10. An extensive Study of Teaching / Learning Quantum Mechanics in College

    CERN Document Server

    Akarsu, Bayram

    2010-01-01

    Quantum physics is considered as one of the most remarkable discoveries of contemporary physics grown during previous century and gradually manifested to the scientific world such as inventions of laser, the transistor, the electron microscope, and semiconductor. Teaching of physical science has been stressed in the National Science Education Standards (NSES) from level K-12 as well as many state science standards (Gossard, 2000). The objectives of the current study are to investigate prospective elucidation of the most common learning difficulties, insufficient teaching strategies and other significant instructional or conceptual problems encountered by science and engineering college students at the senior and/or junior level during the instruction of Quantum Physics. Although conceptual issues about learning and teaching of Quantum Physics were addressed in the current study, I mainly focused on the ways the teachers approach teaching it, as well as considerations of how the classroom environments should f...

  11. A cross-cultural comparison of brand extension success factors: A meta-study

    NARCIS (Netherlands)

    Henseler, Jörg; Horvath, Csilla; Sarstedt, Marko; Zimmermann, Lorenz

    2010-01-01

    In this article, we examine the influence of cross-cultural traits on brand extension success. Drawing on prior brand extension studies from different countries, we conduct a comprehensive meta-analysis, complementing the data sets with Hofstede's cultural dimensions values. Our results show that al

  12. Using C Language Extensions for Developing Embedded Software: A Case Study

    NARCIS (Netherlands)

    Voelter, M.; Van Deursen, A.; Kolb, B.; Eberle, S.

    2015-01-01

    We report on an industrial case study on developing the embedded software for a smart meter using the C programming language and domain-specific extensions of C such as components, physical units, state machines, registers and interrupts. We find that the extensions help significantly with managing

  13. Posterior muscle chain activity during various extension exercises: An observational study

    NARCIS (Netherlands)

    E.M. de Ridder (Eline Md); J.O. van Oosterwijck (Jessica O); A. Vleeming (Andry); G.G. Vanderstraeten (Guy G); L.A. Danneels (Lieven A)

    2013-01-01

    textabstractBackground: Back extension exercises are often used in the rehabilitation of low back pain. However, at present it is not clear how the posterior muscles are recruited during different types of extension exercises. Therefore, the present study will evaluate the myoelectric activity of th

  14. Power Extension Package (PEP) system definition extension, orbital service module systems analysis study. Volume 3: PEP analysis and tradeoffs

    Science.gov (United States)

    1979-01-01

    The objectives, conclusions, and approaches for accomplishing 19 specific design and analysis activities related to the installation of the power extension package (PEP) into the Orbiter cargo bay are described as well as those related to its deployment, extension, and retraction. The proposed cable handling system designed to transmit power from PEP to the Orbiter by way of the shuttle remote manipulator system is described and a preliminary specification for the gimbal assembly, solar array drive is included.

  15. From Extension Science to Communication and Innovation Studies. New Theoretical Trends from Wageningen.

    Science.gov (United States)

    Heymann, F. V.

    1998-01-01

    Wageningen University's extension science program shifted from a positivist to a constructivist foundation. Participatory methodologies and interactive policies are being developed, and the program's name has been changed to Communication and Innovation Studies. (SK)

  16. Power Extension Package (PEP) system definition extension, orbital service module systems analysis study. Volume 12: PEP data item descriptions

    Science.gov (United States)

    1979-01-01

    Contractor information requirements necessary to support the power extension package project of the space shuttle program are specified for the following categories of data: project management; configuration management; systems engineering and test; manufacturing; reliability, quality assurance and safety; logistics; training; and operations.

  17. Power Extension Package (PEP) system definition extension, orbital service module systems analysis study. Volume 4: PEP functional specification

    Science.gov (United States)

    1979-01-01

    The functional, performance, design, and test requirements for the Orbiter power extension package and its associated ground support equipment are defined. Both government and nongovernment standards and specifications are cited for the following subsystems: electrical power, structural/mechanical, avionics, and thermal control. Quality control assurance provisions and preparation for delivery are also discussed.

  18. Power Extension Package (PEP) system definition extension, orbital service module systems analysis study. Volume 5: PEP environmental specification

    Science.gov (United States)

    1979-01-01

    This specification establishes the natural and induced environments to which the power extension package may be exposed during ground operations and space operations with the shuttle system. Space induced environments are applicable at the Orbiter attach point interface location. All probable environments are systematically listed according to each ground and mission phase.

  19. Long-term safety and efficacy of once-daily topical brimonidine tartrate gel 0.5% for the treatment of moderate to severe facial erythema of rosacea: results of a 1-year open-label study.

    Science.gov (United States)

    Moore, Angela; Kempers, Steven; Murakawa, George; Weiss, Jonathan; Tauscher, Amanda; Swinyer, Leonard; Liu, Hong; Leoni, Matthew

    2014-01-01

    Once-daily topical brimonidine tartrate (BT) gel 0.5% was shown to be efficacious and safe for the treatment of erythema of rosacea in previous studies including a 4-week treatment phase. In the present 1-year study, we aimed to assess the long-term safety and efficacy of the treatment. Subjects with moderate to severe erythema of rosacea were instructed to apply topical BT gel 0.5% once daily for 12 months. Severity of erythema and adverse events (AEs) were evaluated. Approximately 345 subject years of exposure to BT gel 0.5% was achieved in the study. The incidence of AEs and AEs judged to be related to the study drug was higher at the beginning and decreased over the course of the study. Similar safety profiles were observed between the subjects who had received or not received concomitant therapies for the inflammatory lesions of rosacea. Effect of topical BT gel 0.5% on erythema severity was observed after the first application and the durability of the effect was maintained until the end of the study at month 12, with no tachyphylaxis observed. In conclusion, once-daily topical BT gel 0.5% is safe and consistently effective for the long-term treatment of moderate to severe erythema of rosacea, even in the presence of concomitant therapies for the inflammatory lesions of rosacea.

  20. Influence of a secondary downsizing of the femoral component on the extension gap: a cadaveric study.

    Science.gov (United States)

    Sriphirom, Pornpavit; Raungthong, Nathee; Chutchawan, Pirapon; Thiranon, Chaiyot; Sukandhavesa, Nantawit

    2012-10-01

    The purpose of this study was to evaluate the effect of a secondary reduction of the femoral component size on flexion and extension gaps intraoperatively in posterior-stabilized total knee arthroplasty (PS-TKA) monitored by computer-assisted surgery. The authors hypothesized that cutting additional bone on the posterior femoral condyle may increase the extension gap due to the posterior capsule and soft tissue loosening. Reduction of the femoral component size was performed by additional 4-in-1 cuts after the PS-TKA on 15 cadaveric knees using a ligamentous tension device with the aid of computer-assisted surgery. Measurements of the medial and lateral flexion gaps, as well as the medial and lateral extension gaps, were recorded before and after reducing the femoral component size. Trial components were used from a mobile-bearing total knee system.After reducing the femoral component size, the medial and lateral flexion and extension gaps measured larger than their initial size. The mean increases of the medial extension and flexion gaps and the lateral extension and flexion gaps were 1.3 ± 0.9, 1.0 ± 1.2, 1.1 ± 1.2, and 1.3 ± 1.3 mm, respectively; all 4 differences were significant (P ≤ .05). Surgeons should be aware of the effect of downsizing components intraoperatively because it might lead to an extension laxity. Thus, a downsizing of the femoral component may compromise the postoperative stability of TKA.

  1. Process skill rather than motor skill seems to be a predictor of costs for rehabilitation after a stroke in working age; a longitudinal study with a 1 year follow up post discharge

    Directory of Open Access Journals (Sweden)

    Björkdahl Ann

    2007-12-01

    Full Text Available Abstract Background In recent years a number of costs of stroke studies have been conducted based on incidence or prevalence and estimating costs at a given time. As there still is a need for a deeper understanding of factors influencing these costs the aim of this study was to calculate the direct and indirect costs in a younger ( Methods Fifty-eight patients included in a study of home rehabilitation and followed for 1 year after discharge from the rehabilitation unit, were interviewed about their use of health care services, assistance, medications and assistive devices. Costs (defined as the cost for society were calculated. A linear regression of cost and variables of functioning, ability, community integration and health-related quality of life was done. Results Inpatient care contributed substantially to the direct cost with a mean length of stay of 92 days. Rehabilitation during the first year constituted of an average of 28 days in day clinics, 38 physiotherapy sessions and 20 occupational therapy sessions. The total direct mean cost was 80 020 € and the indirect cost 35 129 €. The direct costs were influenced by the process skill (the ability to plan and perform a given task and to adapt when needed and presence of aphasia. Indirect costs for informal care giving increased for patients with a lower health-related quality of life as well as a low score on home integration. Conclusion Costs are high in this group of young (

  2. Power Extension Package (PEP) system definition extension, orbital service module systems analysis study. Volume 1: Executive summary

    Science.gov (United States)

    1979-01-01

    An array deployment assembly, power regulation and control assembly, the necessary interface, and display and control equipment comprise the power extension package (PEP) which is designed to provide increased power and duration, as well as reduce fuel cell cryogen consumption during Spacelab missions. Compatible with all currently defined missions and payloads, PEP imposes minimal weight and volume penalties on sortie missions, and can be installed and removed as needed at the launch site within the normal Orbiter turnaround cycle. The technology on which it is based consists of a modified solar electric propulsion array, standard design regulator and control equipment, and a minimally modified Orbiter design. The requirements from which PEP was derived, and the system and its performance capabilities are described. Features of the recommended project are presented.

  3. A Global Worldview among Extension Professionals: A Case Study of Best Practices for Study Abroad Programs

    Science.gov (United States)

    Lockett, Landry; Moore, Lori; Wingenbach, Gary

    2014-01-01

    Globalization and diversifying communities in the United States mandate internationally minded Extension professionals and programming. The knowledge necessary for successfully working in international agricultural and Extension education is vast and takes time to acquire. A catalyst for this learning process is participation in university- or…

  4. Limiting factors of exercise performance 1 year after lung transplantation

    NARCIS (Netherlands)

    Reinsma, G. D.; ten Hacken, N. H. T.; Grevink, R. G.; van der Bij, W.; Koer, G. H.; van Weert, E.

    2006-01-01

    Background: After lung transplantation (LTx). exercise capacity frequently remains limited, despite significantly improved pulmonary function. The aim of this study was to evaluate maximal exercise capacity and peripheral muscle force before and 1 year after LTx, and to determine whether peripheral

  5. Liver transplantation before 1 year of age

    Science.gov (United States)

    Esquivel, Carlos O.; Koneru, Baburao; Karrer, Frederick; Todo, Satoru; Iwatsuki, Shunzaburo; Gordon, Robert D.; Makowka, Leonard; Marsh, Wallis J.; Starzl, Thomas E.

    2010-01-01

    Since 1981, 20 infants younger than 1 year of age received 26 orthotopic liver transplants. Immunosuppression was with cyclosporine and corticosteroids. Thirteen (65%) of the recipients were discharged from the hospital. To date, 12 (60%) of the 20 recipients are surviving, with follow-up of 1 to 56 months (average 14 months). The 5-year actuarial survival is 53.8%. The allograft liver function in the majority of surviving infants is excellent. The predominant causes of mortality were primary nonfunction of the allograft (three patients) and sepsis (three). Major morbidity was caused by hepatic artery thrombosis (five patients), gastrointestinal complications (six), biliary tract complications (five), and bacterial and viral infections (13). Six patients underwent retransplantation; three of these six survived. Results could be improved by prevention of hepatic artery thrombosis, by decreasing the incidence of sepsis, and by procurement of more and better suited pediatric donors. PMID:3550022

  6. Coping behaviour of extension agents in role conflict situations: a case study in Xinji county, China

    NARCIS (Netherlands)

    Huang, R.Q.

    1998-01-01

    This book is about the coping behaviour of extension agents in role conflict situations in a changing environment in China. The study presents the case of cotton production in Xinji county, China.Chapter 1 gives background information on Chinese agricultural and rural reform since 1978 and its impac

  7. Meeting Extension Programming Needs with Technology: A Case Study of Agritourism Webinars

    Science.gov (United States)

    Rich, Samantha Rozier; Komar, Stephen; Schilling, Brian; Tomas, Stacy R.; Carleo, Jenny; Colucci, Susan J.

    2011-01-01

    As clientele needs diversify, Extension educators are examining new technologies, including online tools, to deliver educational programming and resources. Using agritourism as the educational topic, the study reported here sought to evaluate participants' acceptance of online educational programming (webinars) and the effectiveness of the…

  8. In vivo knee laxity in flexion and extension: a radiographic study in 30 older healthy subjects.

    NARCIS (Netherlands)

    Heesterbeek, P.J.; Verdonschot, N.J.J.; Wymenga, A.B.

    2008-01-01

    In order to determine how "tight" a total knee prosthesis should be implanted, it is important to know the amount of laxity in a healthy knee. The objective of this study was to determine knee laxity in extension and flexion in healthy, non-arthritic knees of subjects similar in age to patients unde

  9. Study on Winter Survival of the 1-year-old Seedlings of 19 Landscaping Tree Species%19种园林绿化树木1年生播种苗越冬研究

    Institute of Scientific and Technical Information of China (English)

    马晓辉; 刘燕; 王良民

    2012-01-01

    In this experiment, freezing injuries in winter for the 1-year-old seedlings of 19 landscaping tree species common in the central Shanxi were compared to examine the winter survival ability of landscaping tree seedlings and to provide a practical reference guide for seedling propagation in the area. The results indicated: (1) the 1-year-old seedlings of Acer mono, Platycladus orientalis, Fraxinus pennsylvanica, Euonymus bungeanus, Koelreuteria paniculata, Gleditsia japonica, Syringa reticulata and Ligustrum obtusifolum could safely survive winter in the area, without or with little freezing injuries. Seedling propagation was appropriate for these species in the area. (2) The seedlings of Firmiana simplex and Hibiscus syriacus suffered most serious freezing injuries, resulting in very low survival rates despite under protection in the winter. Seedling propagation was not appropriate for the two species in the area. (3) The seedlings of Cornus alba, Albizia julibrissin, Pterocarya stenoptera, Acer negundo, Platanus acerifolia, Cercis chinensis, Toona sinensis, Lagerstroemia indica and Catalpa bungei suffered varying degrees of freezing injuries and needed to be observed in the second even third winters to decide if seedling propagation was appropriate for these species in this area. (4) The freezing injury index with properly weighted class 4 could more objectively reflect and compare freezing injuries of the different tree seedlings. The results from this study could provide a practical reference guide for seedling propagation of the 19 species in the area.%为了检测山西中部园林绿化树种播种苗的越冬特性,进而为苗木培育提供实用参考依据,对19种山西中部地区常见的园林绿化树种的1年生播种苗进行了越冬受冻害比较研究.结果表明:(1)五角枫、侧柏、洋白蜡、丝棉木、栾树、山皂荚、暴马丁香和水蜡的1年生播种苗可以在该地区安全越冬,不受冻害影响或受冻害影响很

  10. Why Work for Extension? An Examination of Job Satisfaction and Motivation in a Statewide Employee Retention Study

    Science.gov (United States)

    Harder, Amy; Gouldthorpe, Jessica; Goodwin, Jeff

    2014-01-01

    Understanding motivation and job satisfaction is important for increasing rates of employee retention within Extension. The purpose of the study reported here was to explore factors positively affecting the motivation of Extension professionals in their careers. An online survey of Extension professionals in Colorado was conducted. Factors such as…

  11. Power Extension Package (PEP) system definition extension, orbital service module systems analysis study. Volume 10: PEP project plan

    Science.gov (United States)

    1979-01-01

    Contents: project plan summary; project and mission objectives; related studies and technology support activities; technical summary; management; procurement approach; project definition items and schedule; resources; management review; controlled items; and safety, reliability, and quality assurance.

  12. Economic feasibility study for intensive and extensive wastewater treatment considering greenhouse gases emissions.

    Science.gov (United States)

    Molinos-Senante, M; Hernández-Sancho, F; Sala-Garrido, R; Cirelli, G

    2013-07-15

    Economic feasibility assessments represent a key issue for selecting which wastewater treatment processes should be implemented. The few applications that exist focus on the positive economic value of externalities, overlooking the existence of negative externalities. However, wastewater treatment plants (WWTPs) consume a significant amount of energy, contributing to climate change. In this context, as a pioneering approach, greenhouse gas emissions (GHG) have been incorporated as a negative externality of wastewater treatment. Within this framework, this study aims to compare the economic feasibility of five technologies, both intensive and extensive, for small communities. The results show that both the investment and operation costs are higher for intensive than for extensive technologies. Moreover, significant differences in the value of negative externalities were observed. This study demonstrates that from an economic perspective, constructed wetland is the most suitable option for treating wastewater in small agglomerations.

  13. The experience of family members of ICU patients who require extensive monitoring: a qualitative study.

    Science.gov (United States)

    Smith, Claudia DiSabatino; Custard, Kristi

    2014-09-01

    A mixed methods study using family research with a phenomenological approach (n = 5 families) was conducted to explore family members' perceptions about the extensive monitoring technology used on their critically ill family member after cardiac surgery, as experienced when family members initially visited the patient in the cardiovascular intensive care unit. Five relevant themes emerged: overwhelmed by all of the machines; feelings of uncertainty; methods of coping; meaning of the numbers on the machines; and need for education.

  14. A Study of Agricultural Technology Extension and Synchronous Development of Agricultural Modernization,Urbanization and Industrialization in China

    Institute of Scientific and Technical Information of China (English)

    Bibo HU

    2016-01-01

    Through the study of relationship between agricultural technology extension and the development of agricultural modernization,urbanization and industrialization,it is found that agricultural technology extension is an important means to achieve synchronous development of agricultural modernization,urbanization and industrialization. Based on the sample data in China during 1978-2011,we perform the empirical analysis using VAR model and cointegration analysis and impulse response methods. The results show that there is a long-term positive equilibrium relationship between agricultural technology extension and the development of agricultural modernization,urbanization and industrialization,and agricultural technology extension plays a role in promoting agricultural modernization,urbanization and industrialization to varying degrees. Finally,it is concluded that there is a need to establish efficient agricultural technology extension mechanism and diversified agricultural technology extension investment mechanism to make agricultural technology extension better promote China’s agricultural modernization,urbanization and industrialization.

  15. An Optimal Observing System Study for the Kuroshio Extension using Particle Filters

    Science.gov (United States)

    Kramer, Werner; van Leeuwen, Peter Jan; Pierieni, Stefano; Dijkstra, Henk

    2010-05-01

    The Kuroshio Extension - the eastward-flowing free jet formed when the warm waters of the Kuroshio separate from the Japanese coast - reveals bimodal behavior. It changes from an elongated, energetic meandering jet into a weaker, unstable jet with a reduced zonal penetration. Many of its characteristics, e.g. the decadal period and the more stable character of the elongated state, are also observed in a reduced-gravity ocean model of the northern Pacific basin with a schematic Japanese coastline driven by a constant double-gyre wind field. The success of this idealized model suggests that intrinsic nonlinear mechanisms play a major role in determining the meander pattern of the mean flow. The low complexity of the model makes it ideal to perform an observing system study. Here, we take a new approach by using particle filters to assimilate observations into the model. An ensemble of model states is integrated over time from an initial distribution. The first approach is to pick one run as the synthetic truth. Observations are produced from this synthetic truth with an additional observation error. The particle filter technique adjusts the weight of each ensemble run - each particle - according to the observation value and the error distribution. From the ensemble and its weight distribution the expectation and probability distribution of the state vector can be computed. As the ensemble itself is not altered by the filter, different sets of observations, e.g. with different geometrical configurations, locations and/or time resolutions, can be analyzed a posteriori. The particle filter analyses allows us to identify which observations have a large impact on reconstructing the true state of Kuroshio Extension. More precisely, which observations contribute to a (local) reduction in the entropy of the ensemble. In a way each observation is then linked to an area of influence, which permits for determining the flow of information. We will present results where

  16. The Empirical Study in Rising Life Expectancy by 1 Year in China%“人均预期寿命提高1岁”的实证研究

    Institute of Scientific and Technical Information of China (English)

    苟晓霞

    2012-01-01

    温家宝总理在政府工作报告中首次提出十二五时期"人均预期寿命提高1岁"的目标。本文在生命表数据基础上,通过计算平均预期寿命贡献率并进行相关分析与回归分析后得出:我国目前平均预期寿命虽然已高于绝大多数发展中国家,但其绝对增速正逐渐放慢。而降低60~90岁年龄段老年人口死亡率、提高居民消费水平、缩小家庭规模、迁移有条件的离退休老人到低海拔地区养老是实现人均预期寿命提高1岁目标的有效路径。%Wen Jiabao proposed to rise life expectancy by 1 year in 2015 in the government work report.It is significant.Based on the complete life tables,this paper calculated contribution rate of life expectancy,did correlation and regression analysis.Conclusion: At present,the life expectancy in China is higher than that in most of developing countries,but the growth rate slowing down.The effective paths to achieve the goal of rising life expectancy by 1 year include: reducing mortality of 60~90 age,raising the level of consumption,reducing family size and migrating retired old people to live in low altitude areas.

  17. A Detailed Study about Foraging Behavior of Artificial Bee Colony (ABC and its Extensions

    Directory of Open Access Journals (Sweden)

    S.Santhosh Kumar

    2013-04-01

    Full Text Available Swam intelligence is an emerging field in Artificial Intelligence. The living nature and life style of animals, birds and other living organisms can be inherited and applied to solve many real worldproblems. ABC is a recently developed swam intelligence algorithm developed by Dervis Karaboga in the year 2005.In ABC, foraging is one of the behavior of honey bees to search, collect food from its foodresources. Many research works has undergone about foraging behavior and it is applied to solve variety of optimization problems. This paper discusses the detailed study of different types of extensions offoraging behavior of honey bees.

  18. Natural history of extensive diaphragmatic injury on the right side: experimental study in rats

    Directory of Open Access Journals (Sweden)

    Jorge Henrique Rivaben

    2014-08-01

    Full Text Available OBJECTIVE: To evaluate the natural healing of the rat diaphragm that suffered an extensive right penetrating injury.METHODS: Animals were submitted to an extensive penetrating injury in right diaphragm. The sample consisted of 40 animals. The variables studied were initial weight, weight 21 days after surgery; healing of the diaphragm, non-healing of the diaphragm, and herniated abdominal contents into the chest.RESULTS: Ten animals were used as controls for weight and 30 animals were operated. Two animals died during the experiment, so 28 animals formed the operated group; healing of the diaphragm occurred in 15 animals (54%, 11 other animals showed diaphragmatic hernia (39% and in two we observed only diaphragmatic injury without hernia (7%. Among the herniated organs, the liver was found in 100% of animals, followed by the omentum in 77%, small bowel in 62%, colon in 46%, stomach in 31% and spleen in 15%. The control group and the diaphragmatic healing subgroup showed increased weight since the beginning of the study and the 21 days after surgery (p <0.001. The unhealed group showed no change in weight (p = 0.228.CONCLUSION: there is a predominance of spontaneous healing in the right diaphragm; animals in which there was no healing of the diaphragm did not gain weight, and the liver was the organ present in 100% the diaphragmatic surface in all rats with healed diaphragm or not.

  19. Efficacy and safety of eculizumab in atypical hemolytic uremic syndrome from 2-year extensions of phase 2 studies

    NARCIS (Netherlands)

    Licht, C.; Greenbaum, L.A.; Muus, P.; Babu, S.; Bedrosian, C.L.; Cohen, D.J.; Delmas, Y.; Douglas, K.; Furman, R.R.; Gaber, O.A.; Goodship, T.; Herthelius, M.; Hourmant, M.; Legendre, C.M.; Remuzzi, G.; Sheerin, N.; Trivelli, A.; Loirat, C.

    2015-01-01

    Atypical hemolytic uremic syndrome (aHUS) is a rare, possibly life-threatening disease characterized by platelet activation, hemolysis and thrombotic microangiopathy (TMA) leading to renal and other end-organ damage. We originally conducted two phase 2 studies (26 weeks and 1 year) evaluating eculiz

  20. The Use of an e-Learning System for Agricultural Extension: A Case Study of the Rural Development Administration, Korea

    Science.gov (United States)

    Park, Duk-Byeong; Cho, Yong-Been; Lee, Minsoo

    2007-01-01

    The study explores the e-learning system of the Computer-Based Agricultural Extension Program (CBAES) and examines the differences in user satisfaction and preferences between the two systems for Agricultural Education and Extension at the Rural Development Administration (RDA) in Korea. It also describes the architecture, services, user…

  1. Balance 1 year after TKA: correlation with clinical variables.

    Science.gov (United States)

    Bascuas, Iria; Tejero, Marta; Monleón, Sandra; Boza, Roser; Muniesa, Josep Maria; Belmonte, Roser

    2013-01-01

    Knee osteoarthritis results in changes that affect balance. It has been reported that osteoarthritis worsens proprioception and increases the risk of falling. The objective of this study was to assess changes in balance among patients with knee osteoarthritis at 1 year after total knee arthroplasty (TKA) surgery and its relationship with clinical variables. This prospective, observational study evaluated 44 patients before and 1 year after TKA. Variables analyzed included age, body mass index, pain, range of motion for both knees, bilateral quadriceps and hamstrings muscle strength, gait velocity, and Knee Society score. Balance and posture control were assessed using the following computerized posturography tests: the weight bearing test, modified Clinical Test of Sensory Interaction on Balance (mCTSIB) test, and sit-to-stand test. Pre- and postoperative differences were analyzed using Wilcoxon and chi-square tests, and effect size was measured using standardized response mean. Correlations were assessed by the Spearman test. One year after TKA, some improvement in balance tests was observed. Significant differences were observed in the mCTSIB test: foam surface with open eyes (P≤.001), foam surface with closed eyes (P≤.001), and composite value (P≤.001). Effect size was moderate to high. Age showed significant correlation with mCTSIB composite value changes (-0.369; P=.037). No significant correlations were found between posturographic tests and other analyzed variables. Balance measured by computerized posturography improved 1 year after TKA. Significant changes were observed between open and closed eyes using a foam surface for the mCTSIB test. A mild negative correlation was found between age and posturographic changes.

  2. A model study of the Gulf Stream Extension intrinsic low-frequency variability

    Science.gov (United States)

    Quattrocchi, Giovanni; Pierini, Stefano; Dijkstra, Henk A.

    2010-05-01

    A process-oriented model study aimed at understanding aspects of the intrinsic low-frequency variability of the Gulf Stream Extension is presented. Reduced-gravity and two-layer shallow water eddy-permitting models are implemented in a domain spanning the latitudes from 10°S to 60°N, with schematic coastlines representing correctly the large-scale shape of the continental boundaries. The forcing, provided by a time-independent climatological wind stress field, is obtained from 41 years (1961-2001) of ECMWF Re-Analysis data. In the two-layer model a Deep Western Boundary Current is introduced through boundary forcing. The dissipative mechanisms are the lateral eddy viscosity (with coefficient A) and the interfacial friction (with coefficient F) and, in the two-layer model, also the bottom friction. Sensitivity experiments are carried out by varying A and F, and the results are interpreted also in terms of dynamical systems theory. For sufficiently high dissipation a steady western boundary current and corresponding extension jet are obtained: their comparison with AVISO altimeter data provides experimental validation of the model setup. Decreasing A and F leads to a first Hopf bifurcation and to the successive transition to chaotic fluctuations characterized by interannual time scales. A thorough analysis is carried out also by considering previous work on more idealized double-gyre flows.

  3. OpenARC: Extensible OpenACC Compiler Framework for Directive-Based Accelerator Programming Study

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Seyong [ORNL; Vetter, Jeffrey S [ORNL

    2014-01-01

    Directive-based, accelerator programming models such as OpenACC have arisen as an alternative solution to program emerging Scalable Heterogeneous Computing (SHC) platforms. However, the increased complexity in the SHC systems incurs several challenges in terms of portability and productivity. This paper presents an open-sourced OpenACC compiler, called OpenARC, which serves as an extensible research framework to address those issues in the directive-based accelerator programming. This paper explains important design strategies and key compiler transformation techniques needed to implement the reference OpenACC compiler. Moreover, this paper demonstrates the efficacy of OpenARC as a research framework for directive-based programming study, by proposing and implementing OpenACC extensions in the OpenARC framework to 1) support hybrid programming of the unified memory and separate memory and 2) exploit architecture-specific features in an abstract manner. Porting thirteen standard OpenACC programs and three extended OpenACC programs to CUDA GPUs shows that OpenARC performs similarly to a commercial OpenACC compiler, while it serves as a high-level research framework.

  4. Extension Trial of Qigong for Fibromyalgia: A Quantitative and Qualitative Study

    Directory of Open Access Journals (Sweden)

    Jana Sawynok

    2013-01-01

    Full Text Available This extension trial is an open-label observational trial of 20 subjects with fibromyalgia who undertook level 2 Chaoyi Fanhuan Qigong (CFQ training following an earlier controlled trial of level 1 CFQ. Subjects practiced 60 min/day for 8 weeks and continued some daily practice for 6 months. Quantitative measures, assessed at baseline, 8 weeks, 4 and 6 months, were of pain, impact, sleep, physical and mental functions, and practice time. Qualitative comments also were recorded. Compared to baselines, CFQ practice led to significant improvements in pain, impact, sleep, and physical function in the 13 subjects (65% who completed the trial; changes were present at 8 weeks and were maintained for the 6-month trial duration. A highly motivated subgroup of N=5, who practiced the most, had the best outcomes in terms of end symptomology, and qualitative comments indicated health benefits in other domains as well. Qualitative comments by the remaining N=8 trial completers and N=7 withdrawals indicate different experiences with the practice. This extension trial indicates that diligent CFQ practice over time produces significant health gains in fibromyalgia in a subset of individuals. Future studies will need to address factors that might predispose to favourable outcomes.

  5. Preliminary results of an extensive study of fragmentation measurements for medical and space applications

    CERN Document Server

    Agodi, C; Calabretta, L; Cirrone, G A P C; Cuttone, G; De Napoli, M; Fiorini, F; Giacoppo, F; Mairani, A; Morone, M C; Patera, V; Raciti, G; Rapisarda, E; Ricciardi, V; Romano, F; Sala, P; Sciubba, A

    2010-01-01

    Here we report on preliminary results of an extensive study of fragmentation cross sections measurements useful for medical and space applications. In particular, we looked at the hadrontherapy and space radiation research. Indeed, the measure of fragmentation cross sections is an important information to estimate how this process modifies dose distributions and biological effectiveness, both inside human body and spacecraft. In this picture we started to measure the fragmentation of 12C beam accelerated by the Superconducting Cyclotron at 32 AMeV, 62 AMeV on 12C, 207Pb and 197Au at the INFN Laboratory Nazionali del Sud in Catania (Italy). Preliminary comparison between absolute cross-sections measured for the systems: 12C+207Pb at 32AMeV and for 12C+197Au at 62AMeV is performed.

  6. Clinical and Serum-Based Markers Are Associated with Death within 1 year of de novo Implant in Primary Prevention ICD Recipients

    Science.gov (United States)

    Zhang, Yiyi; Guallar, Eliseo; Blasco-Colmenares, Elena; Dalal, Darshan; Butcher, Barbara; Norgard, Sanaz; Tjong, Fleur V. Y.; Eldadah, Zayd; Dickfeld, Timm; Ellenbogen, Kenneth A.; Marine, Joseph E.; Tomaselli, Gordon F.; Cheng, Alan

    2014-01-01

    Background Implantable cardioverter defibrillator (ICD) implantation is contraindicated in those with <1 year life expectancy. Objective To develop a risk prediction score for 1-year mortality in patients with primary prevention ICDs and to determine the incremental improvement in discrimination when incorporating serum-based biomarkers to traditional clinical variables. Methods We analyzed data from the PROSE-ICD study, a large prospective observational study of patients undergoing primary prevention ICD implantation who were extensively phenotyped for clinical and serum markers. We identified variables predicting 1-year mortality and synthesized them into a comprehensive risk scoring construct using backward selection. Results Among 1,189 patients deemed by their treating physicians as having reasonable 1 year life expectancy, 62 patients died within 1 year of ICD implantation. The risk score, comprised of 6 clinical factors (age ≥75 years, New York Heart Association class III/IV, atrial fibrillation, eGFR <30mL/min/1.73m2, diabetes, and use of diuretics), had good discrimination (AUC=0.77) for 1-year mortality. Addition of 3 biomarkers (TNF-αRII, pro-BNP, and cTnT) further improved model discrimination to 0.82. Patients with 0-1, 2-3, 4-6, or 7-9 risk factors had 1-year mortality rates of 0.8%, 2.7%, 16.1% and 46.2%, respectively. Conclusions Individuals with more co-morbidities and elevations of specific serum biomarkers were at increased risk for all-cause mortality despite being deemed as having reasonable 1 year life expectancy. A simple risk score comprised of readily available clinical data and serum biomarkers may better identify patients at high risk of early mortality and improve patient selection and counseling for primary prevention ICD therapy. PMID:25446153

  7. Study of muon bundles from extensive air showers with the ALICE detector at CERN LHC

    Science.gov (United States)

    Shtejer, K.

    2016-05-01

    ALICE is one of four large experiments at the CERN Large Hadron Collider, specially designed to study particle production in ultra-relativistic heavy-ion collisions. Located 52 meters underground with 28 meters of overburden rock, it has also been used to detect muons produced by cosmic-ray interactions in the upper atmosphere. The large size and excellent tracking capability of the ALICE Time Projection Chamber are exploited to study the muonic component of extensive air showers. We present the multiplicity distribution of these atmospheric muons and its comparison with Monte Carlo simulations. The latest version of the QGSJET hadronic interaction model was used to simulate the development of the resulting air showers. High multiplicity events containing more than 100 reconstructed muons were also studied. Similar events have been studied in previous underground experiments such as ALEPH and DELPHI at LEP without satisfactory explanations for the frequency of the highest multiplicity events. We demonstrate that the high muon-multiplicity events observed in ALICE stem from primary cosmic rays with energies above 1016 eV and that the frequency of these events can be successfully described by assuming a heavy mass composition of primary cosmic rays in this energy range.

  8. Extensive occupational finger use delays age effects in tactile perception-an ERP study.

    Science.gov (United States)

    Reuter, Eva-Maria; Voelcker-Rehage, Claudia; Vieluf, Solveig; Winneke, Axel H; Godde, Ben

    2014-05-01

    Tactile expertise, resulting from extensive use of hands, has previously been shown to improve tactile perception in blind people and musicians and to be associated with changes in the central processing of tactile information. This study investigated whether expertise, due to precise and deliberate use of the fingers at work, relates to improved tactile perception and whether this expertise interacts with age. A tactile pattern and a frequency discrimination task were conducted while ERPs were measured in experts and nonexperts of two age groups within middle adulthood. Independently of age, accuracy was better in experts than in nonexperts in both tasks. Somatosensory N70 amplitudes were larger with increasing age and for experts than for nonexperts. P100 amplitudes were smaller in experts than in nonexperts in the frequency discrimination task. In the pattern discrimination task, P300 difference wave amplitude was reduced in experts and late middle-aged adults. In the frequency discrimination task, P300 was more equally distributed in late middle-aged adults. We conclude that extensive, dexterous manual work leads to acquisition of tactile expertise and that this expertise might delay, but not counteract, age effects on tactile perception. Comparable neurophysiological changes induced by age and expertise presumably have different underlying mechanisms. Enlarged somatosensory N70 amplitudes might result from reduced inhibition in older adults but from enhanced, specific excitability of the somatosensory cortex in experts. Regarding P300, smaller amplitudes might indicate fewer available resources in older adults and, by contrast, a reduced need to engage as much cognitive effort to the task in experts.

  9. An investigation of impact of Brand Extension on Parent Brand Image: A case study of Johnson, UK

    Directory of Open Access Journals (Sweden)

    Muhammad Shakil Ahmad

    2011-05-01

    Full Text Available Purpose of study: The main purpose of this study is to investigate the impact of brand extensions on parent brand image. For this purpose Johnson is selected as parent brand for current study. The selected brand extensions are Johnson shampoo, Johnson’s isotonic drinks, Johnson’s sportswear and Johnson’s suntan lotion. Research Methodology: sample was selected from Bradford, UK. Sample consists of consumer of Johnson including males as well as female. Total sample size is 250 and data was collected through self administered questionnaires. Convenience sampling was selected as sampling technique. Results: Correlation analysis indicated negative impact of brand extension on parent brand image if brand extension is done in different brand categories. Perceived brand quality and perceived brand fit of the extension also affect the parent brand image. Conclusion: It is concluded that if brand extension is done in the same product category of parent brand then there is possibly high acceptance for the brand extension rather than in the different product categories.

  10. Developing Sustainable Farmer-Led Extension Groups: Lessons from a Bangladeshi Case Study

    Science.gov (United States)

    Islam, Md. Mofakkarul; Gray, David; Reid, Janet; Kemp, Peter

    2011-01-01

    The limited effectiveness and fiscal unsustainability of professional-led public sector extension systems in developing countries have aroused considerable interest in Farmer-led Extension (FLE) approaches in the recent decades. A key challenge facing these initiatives is a lack of sustainability of the farmer groups developed through project or…

  11. Online Extensive Reading for Advanced Foreign Language Learners: An Evaluation Study

    Science.gov (United States)

    Arnold, Nike

    2009-01-01

    The following article reports the findings of a qualitative evaluation of an online extensive reading program in German as a foreign language. Designed for advanced learners, it differs from traditional extensive reading programs in two important aspects: students read online instead of printed materials, and there was no teacher preselection to…

  12. Towards a cosmic-ray mass-composition study at Tunka Radio Extension

    Science.gov (United States)

    Kostunin, D.; Bezyazeekov, P. A.; Budnev, N. M.; Fedorov, O.; Gress, O. A.; Haungs, A.; Hiller, R.; Huege, T.; Kazarina, Y.; Kleifges, M.; Korosteleva, E. E.; Krömer, O.; Kungel, V.; Kuzmichev, L. A.; Lubsandorzhiev, N.; Mirgazov, R. R.; Monkhoev, R.; Osipova, E. A.; Pakhorukov, A.; Pankov, L.; Prosin, V. V.; Rubtsov, G. I.; Schröder, F. G.; Wischnewski, R.; Zagorodnikov, A.

    2017-03-01

    The Tunka Radio Extension (Tunka-Rex) is a radio detector at the TAIGA facility located in Siberia nearby the southern tip of Lake Baikal. Tunka-Rex measures air-showers induced by high-energy cosmic rays, in particular, the lateral distribution of the radio pulses. The depth of the air-shower maximum, statistically depends on the mass of the primary particle, is determined from the slope of the lateral distribution function (LDF). Using a model-independent approach, we have studied possible features of the one-dimensional slope method and tried to find improvements for the reconstruction of primary mass. To study the systematic uncertainties given by different primary particles, we have performed simulations using the CONEX and CoREAS software packages of the recently released CORSIKA v7.5 including the modern high-energy hadronic models QGSJet-II.04 and EPOS-LHC. The simulations have shown that the largest systematic uncertainty in the energy deposit is due to the unknown primary particle. Finally, we studied the relation between the polarization and the asymmetry of the LDF.

  13. Study protocol: Audit and Best Practice for Chronic Disease Extension (ABCDE Project

    Directory of Open Access Journals (Sweden)

    Thompson Sandra

    2008-09-01

    Full Text Available Abstract Background A growing body of international literature points to the importance of a system approach to improve the quality of care in primary health care settings. Continuous Quality Improvement (CQI concepts and techniques provide a theoretically coherent and practical way for primary care organisations to identify, address, and overcome the barriers to improvements. The Audit and Best Practice for Chronic Disease (ABCD study, a CQI-based quality improvement project conducted in Australia's Northern Territory, has demonstrated significant improvements in primary care service systems, in the quality of clinical service delivery and in patient outcomes related to chronic illness care. The aims of the extension phase of this study are to examine factors that influence uptake and sustainability of this type of CQI activity in a variety of Indigenous primary health care organisations in Australia, and to assess the impact of collaborative CQI approaches on prevention and management of chronic illness and health outcomes in Indigenous communities. Methods/design The study will be conducted in 40–50 Indigenous community health centres from 4 States/Territories (Northern Territory, Western Australia, New South Wales and Queensland over a five year period. The project will adopt a participatory, quality improvement approach that features annual cycles of: 1 organisational system assessment and audits of clinical records; 2 feedback to and interpretation of results with participating health centre staff; 3 action planning and goal setting by health centre staff to achieve system changes; and 4 implementation of strategies for change. System assessment will be carried out using a System Assessment Tool and in-depth interviews of key informants. Clinical audit tools include two essential tools that focus on diabetes care audit and preventive service audit, and several optional tools focusing on audits of hypertension, heart disease, renal

  14. Towards a cosmic-ray mass-composition study at Tunka Radio Extension (ARENA 2016)

    CERN Document Server

    Kostunin, D; Budnev, N M; Fedorov, O; Gress, O A; Haungs, A; Hiller, R; Huege, T; Kazarina, Y; Kleifges, M; Korosteleva, E E; Krömer, O; Kungel, V; Kuzmichev, L A; Lubsandorzhiev, N; Mirgazov, R R; Monkhoev, R; Osipova, E A; Pakhorukov, A; Pankov, L; Prosin, V V; Rubtsov, G I; Schröder, F G; Wischnewski, R; Zagorodnikov, A

    2016-01-01

    The Tunka Radio Extension (Tunka-Rex) is a radio detector at the TAIGA facility located in Siberia nearby the southern tip of Lake Baikal. Tunka-Rex measures air-showers induced by high-energy cosmic rays, in particular, the lateral distribution of the radio pulses. The depth of the air-shower maximum, which statistically depends on the mass of the primary particle, is determined from the slope of the lateral distribution function (LDF). Using a model-independent approach, we have studied possible features of the one-dimensional slope method and tried to find improvements for the reconstruction of primary mass. To study the systematic uncertainties given by different primary particles, we have performed simulations using the CONEX and CoREAS software packages of the recently released CORSIKA v7.5 including the modern high-energy hadronic models QGSJet-II.04 and EPOS-LHC. The simulations have shown that the largest systematic uncertainty in the energy deposit is due to the unknown primary particle. Finally, we...

  15. Multi-spacecraft observations to study the shock extension in the inner heliosphere

    Science.gov (United States)

    de Lucas, Aline; Schwenn, Rainer; Marsch, Eckart; Lago, Alisson Dal; de Gonzalez, Alicia L. Clúa; Echer, Ezequiel; Gonzalez, Walter D.; da Silva, Marlos R.

    2009-03-01

    The two Helios probes traveled at variable longitudinal and radial separations through the inner heliosphere. They collected most valuable high resolution plasma and magnetic field data for an entire solar cycle. The mission is still so successful that no other missions will collect the same kind of data in the next 20 years. One of the subjects studied after the success of the Helios mission was the identification of more than 390 shock waves driven by Interplanetary Coronal Mass Ejections (ICMEs). Combining the data from both probes, we make a statistical study for the extension of the shock waves in the interplanetary medium. For longitudinal separations of 90° we found a cutoff value at this angular separation. A shock has 50% of chance to be observed by both probes and the same probability for not being observed by two spacecrafts at the same time, when the angle between them is around 90°. We describe the dependence of the probability for shocks to be observed by both probes with decreasing spacecraft separation. Including plasma data from the ISEE-3 and IMP-8 spacecrafts improves our statistical evaluation substantially.

  16. Study on shelf life extension of papayas irradiated by /sup 60/Co gamma-rays

    Energy Technology Data Exchange (ETDEWEB)

    Chang, M.S.; Chen, M.D.; Lin, C.T.; Fu, Y.K.

    1984-11-01

    Papayas are one of the main fresh fruits in Taiwan area. Papaya fruits were treated with hot water to pasteurize peels followed by /sup 60/Co gamma-ray irradiation to extend the ripening time. The purpose of synergetic methods is to extend the shelf life of papaya fruits. This experiment was carried out by seven treatments, which were: (1) control group, (2) hot water treatment only, (3) hot water treatment with a 25 krad ..gamma..-irradiation, (4) hot water treatment with a 50 krad ..gamma..-irradiation, (5) hot water treatment with a 75 krad ..gamma..-irradiation, (6) 75 krad ..gamma..-irradiation only, and (7) hot water treatment with a 100 krad ..gamma..-irradiation. The items of observation were: surface yellowing, surface decaying, quality of texture, and length of period lasted after irradiation for 50% marketable papayas. The results of this study showed that a shelf-life extension of six days could be obtained for papayas subjected to hot water (50 to 55/sup 0/C) treatment and a 100 krad irradiation. 3 refs., 2 figs., 2 tabs.

  17. An Application Domain Extension to CityGML for immovable property taxation: A Turkish case study

    Science.gov (United States)

    Çağdaş, Volkan

    2013-04-01

    It is generally acknowledged that immovable property taxes are one of the main revenue sources for local government. The literature emphasizes that the administration of property taxes needs well-developed inventories or registers that provide complete and accurate records of the taxed properties and their legal-economic attributes. This requirement is generally fulfilled by Spatial Data Infrastructures (SDIs) in which the coordinate exchange and sharing of geo-spatial data is provided by separate registers/information systems such as: cadastral systems, building and address registers. Recently, the Open Geospatial Consortium presented a core component of a 3D SDI in the form of an international domain standard for representing, storing and exchanging 3D city models. The CityGML allows the semantic and 3D geometrical representation of physical objects but does not deal with the legal and administrative aspects of the city objects which are required for the process of property taxation. This paper outlines the development of an Application Domain Extension (ADE) for the immovable property taxation domain that expands the CityGML data model with the legal and administrative concepts defined in Turkish Law. The study shows that this ADE could be a 3D national data model for municipal information systems and facilitate a more efficient taxation process, as well as providing data for urban planning, facility management and other municipal services.

  18. Otitis media with effusion in children younger than 1 year

    Science.gov (United States)

    Di Francesco, Renata Cantisani; Barros, Vivian Boschesi; Ramos, Rafael

    2016-01-01

    Abstract Objective: To determine the prevalence of otitis media with effusion in children younger than 1 year and its association with the season of the year, artificial feeding, environmental and perinatal factors. Methods: Retrospective study of 184 randomly included medical records from a total of 982 healthy infants evaluated for hearing screening tests. Diagnosis of otitis media with effusion was based on otoscopy (amber-gold color, fluid level, handle of malleus position), type B tympanometric curves and absence of otoacoustic emissions. Incomplete medical records or those describing acute otitis media, upper respiratory tract infections on the assessment day or in the last 3 months, neuropathies and craniofacial anomalies were excluded. Data such as gestational age, birth weight, Apgar score, type of feeding and day care attendance were compared between children with and without otitis media with effusion through likelihood tests and multivariate analysis. Results: 25.3% of 184 infants had otitis media with bilateral effusion; 9.2% had unilateral. In infants with otitis media, the following were observed: chronological age of 9.6±1.7 months; gestational age >38 weeks in 43.4% and birth weight >2500g in 48.4%. Otitis media with effusion was associated with winter/fall, artificial feeding, Apgar score <7 and day care attendance. The multivariate analysis showed that artificial feeding is the factor most often associated to otitis media with effusion. Conclusions: Otitis media with effusion was found in about one third of children younger than 1 year and was mainly associated with artificial feeding. PMID:26559603

  19. Otitis media with effusion in children younger than 1 year

    Directory of Open Access Journals (Sweden)

    Renata Cantisani Di Francesco

    2016-06-01

    Full Text Available Abstract Objective: To determine the prevalence of otitis media with effusion in children younger than 1 year and its association with the season of the year, artificial feeding, environmental and perinatal factors. Methods: Retrospective study of 184 randomly included medical records from a total of 982 healthy infants evaluated for hearing screening tests. Diagnosis of otitis media with effusion was based on otoscopy (amber-gold color, fluid level, handle of malleus position, type B tympanometric curves and absence of otoacoustic emissions. Incomplete medical records or those describing acute otitis media, upper respiratory tract infections on the assessment day or in the last 3 months, neuropathies and craniofacial anomalies were excluded. Data such as gestational age, birth weight, Apgar score, type of feeding and day care attendance were compared between children with and without otitis media with effusion through likelihood tests and multivariate analysis. Results: 25.3% of 184 infants had otitis media with bilateral effusion; 9.2% had unilateral. In infants with otitis media, the following were observed: chronological age of 9.6±1.7 months; gestational age >38 weeks in 43.4% and birth weight >2500g in 48.4%. Otitis media with effusion was associated with winter/fall, artificial feeding, Apgar score <7 and day care attendance. The multivariate analysis showed that artificial feeding is the factor most often associated to otitis media with effusion. Conclusions: Otitis media with effusion was found in about one third of children younger than 1 year and was mainly associated with artificial feeding.

  20. Community perceptions on the significant extension of life: an exploratory study among urban adults in Brisbane, Australia.

    Science.gov (United States)

    Underwood, Mair; Bartlett, Helen P; Partridge, Brad; Lucke, Jayne; Hall, Wayne D

    2009-02-01

    Some researchers in the field of ageing claim that significant extension of the human lifespan will be possible in the near future. While many of these researchers have assumed that the community will welcome this technology, there has been very little research on community attitudes to life extension. This paper presents the results of an in-depth qualitative study of community attitudes to life extension across age groups and religious boundaries. There were 57 individual interviews, and 8 focus groups (totalling 72 focus group participants) conducted with community members in Brisbane, Australia. Community attitudes to life extension were more varied and complex than have been assumed by some biogerontologists and bioethicists. While some participants would welcome the opportunity to extend their lives others would not even entertain the possibility. This paper details these differences of opinion and reveals contrasting positions that reflect individualism or social concern among community members. The findings also highlight the relationship between Christianity, in particular belief in an afterlife, and attitudes to life extension technology. Overall, the study raises questions about the relationship between interest in life extension, the medicalisation of ageing and the increasing acceptability of enhancement technologies that need to be addressed in more representative samples of the community.

  1. A 1-year study to compare the hemostatic effects of oral contraceptive containing 20 microg of ethinylestradiol and 100 microg of levonorgestrel with 30 microg of ethinylestradiol and 100 microg of levonorgestrel

    DEFF Research Database (Denmark)

    Jespersen, Jørgen; Endrikat, Jan; Düsterberg, Bernd

    2005-01-01

    OBJECTIVES: To comparatively evaluate the impact of a balanced one-third dose-reduced oral contraceptive on hemostatic variables. METHODS: In an open-label, randomized study, a dose-reduced oral contraceptive containing 20 microg of ethinylestradiol (EE) and 100 microg of levonorgestrel (LNG......) was compared with a reference preparation containing 30 microg of EE and 150 microg of LNG. One-year data were obtained from 48 volunteers. RESULTS: The direction and magnitude of the changes (increase or decrease) in most of the hemostatic variables were similar in both treatment groups. The majority...

  2. Seasonal variations and sources study by way of back trajectories and ANOVA for ambient air pollutants (particulates and metallic elements) within a mixed area at Longjing, central Taiwan: 1-year observation.

    Science.gov (United States)

    Fang, Guor-Cheng; Lo, Chaur-Tsuen; Zhuang, Yuan-Jie; Cho, Meng-Hsien; Huang, Chao-Yang; Xiao, You-Fu; Tsai, Kai-Hsiang

    2017-02-01

    This study measured the concentrations of particulates and metallic elements in ambient air by using PS-1 sampler (TSP) at Longjing area. And this study focuses on the collection of ambient air particulates, metallic elements, particulate-bound mercury Hg(p), concentrations. In addition, the sources of ambient pollutants by way of back trajectory analysis are found. Moreover, test mean concentration variance differences for metallic elements (PM, Hg(p), Mn, Fe, Zn, Cr, Cu, and Pb) among the four seasons (spring, summer, autumn and winter) through ANOVA are calculated. The result indicates that the average highest particulate concentration occurred in winter season, and the order was winter > spring > autumn > summer, and the mostly highest average metallic element (Mn, Fe, Zn, Cr, Cu, Pb) concentrations occurred in autumn. Moreover, the mostly average lowest metallic element concentrations occurred in summer. In addition, the above results of backward trajectories that the major particulate pollutants parcel mainly come from northeastern Taiwan. Moreover, when comparing the results of the first half year to that of the second half year, the they indicated that all metallic elements displayed significant differences in concentrations except those of Hg(p), Mn, Fe, Zn. Finally, metallic element Hg(p) is the only one which showed no significant concentration difference from either seasonal variations or half-year observations.

  3. Power Extension Package (PEP) system definition extension, orbital service module systems analysis study. Volume 11: PEP, cost, schedules, and work breakdown structure dictionary

    Science.gov (United States)

    1979-01-01

    Cost scheduling and funding data are presented for the reference design of the power extension package. Major schedule milestones are correlated with current Spacelab flight dates. Funding distributions provide for minimum expenditure during the first year of the project.

  4. Erosive progression is minimal, but erosion healing rare, in patients with rheumatoid arthritis treated with adalimumab. A 1 year investigator-initiated follow-up study using high-resolution computed tomography as the primary outcome measure

    DEFF Research Database (Denmark)

    Møller Døhn, U; Boonen, A; Hetland, M L;

    2009-01-01

    : Disease activity score, C-reactive protein, tender and swollen joints count and Health Assessment Questionnaire score had all decreased at 6 and 12 months (wilcoxon signed-ranks test pchange in any imaging parameters of joint destruction was observed at 6 and 12 months. High...... two low-grade radiographic erosions in the wrist or metacarpophalangeal (MCP) joints in the same (index) hand, initiated adalimumab 40 mg subcutaneously every other week. Thirty-five patients completed the study (median age 61 years (interquartile range 46-68), disease duration 8 years (3-15)). CT...... intrareader agreements were reached (mean intraobserver intraclass coefficients: 0.96 (CT) and 0.97 (radiography)). The number of patients with change scores exceeding the smallest detectable change (SDC) was comparable on CT and radiography, as were the proportions of patients progressing...

  5. Comparison of volumetric bone mineral density in the operated and contralateral knee after anterior cruciate ligament and reconstruction: A 1-year follow-up study using peripheral quantitative computed tomography.

    Science.gov (United States)

    Mündermann, Annegret; Payer, Nina; Felmet, Gernot; Riehle, Hartmut

    2015-12-01

    The purpose of this study was to quantify changes in volumetric bone mineral density (vBMD) in the tibial plateau of the operated and contralateral leg measured using peripheral quantitative computed tomography (pQCT) before and 3, 6, and 12 months after anterior cruciate ligament (ACL) reconstruction. The ACL was reconstructed with a hamstring tendon autograft using press-fit fixation. pQCT measurements of the proximal tibia were obtained in 61 patients after ACL reconstruction, and total, cortical, and trabecular vBMD were calculated. vBMD in the operated leg decreased from baseline to 3 months (-12% [total], -11% [cortical], and -12.6% [trabecular]; preconstruction contributed to loss in bone mineral density within the first year after surgery. The role of factors such as time of weight-bearing, joint mechanics, post-traumatic inflammatory reactions, or genetic predisposition in modulating the development of posttraumatic knee osteoarthritis after ACL injury should be further elucidated.

  6. The extension of smoke-free areas and acute myocardial infarction mortality: before and after study

    Science.gov (United States)

    Sánchez, Emília; Benet, Josep; Cabezas, Carmen; Castillo, Antonia; Guarga, Alex; Saltó, Esteve; Tresserras, Ricard

    2011-01-01

    Objectives Recent studies suggest that comprehensive smoking regulations to decrease exposure to second-hand smoke reduce the rates of acute myocardial infarction (AMI). The objective of this paper is to analyse if deaths due to AMI in Spain declined after smoking prevention legislation came into force in January 2006. Design Information was collected on deaths registered by the Instituto Nacional de Estadística for 2004–2007. Age- and sex-specific annual AMI mortality rates with 95% CIs were estimated, as well as age-adjusted annual AMI mortality rates by sex. Annual relative risks of death from AMI were estimated with an age-standardised Poisson regression model. Results Adjusted AMI mortality rates in 2004 and 2005 are similar, but in 2006 they show a 9% decline for men and a 8.7% decline for women, especially among those over 64 years of age. In 2007 there is a slower rate of decline, which reaches statistical significance for men (−4.8%) but not for women (−4%). The annual relative risk of AMI death decreased in both sexes (p<0.001) from 1 to 0.90 in 2006, and to 0.86 in 2007. Conclusion The extension of smoke-free regulations in Spain was associated with a reduction in AMI mortality, especially among the elderly. Although other factors may have played a role, this pattern suggests a likely influence of the reduction in population exposure to second-hand smoke on AMI deaths. PMID:22021746

  7. Identifying the Functional Flexion-extension Axis of the Knee: An In-Vivo Kinematics Study.

    Directory of Open Access Journals (Sweden)

    Li Yin

    Full Text Available This study aimed to calculate the flexion-extension axis (FEA of the knee through in-vivo knee kinematics data, and then compare it with two major anatomical axes of the femoral condyles: the transepicondylar axis (TEA defined by connecting the medial sulcus and lateral prominence, and the cylinder axis (CA defined by connecting the centers of posterior condyles.The knee kinematics data of 20 healthy subjects were acquired under weight-bearing condition using bi-planar x-ray imaging and 3D-2D registration techniques. By tracking the vertical coordinate change of all points on the surface of femur during knee flexion, the FEA was determined as the line connecting the points with the least vertical shift in the medial and lateral condyles respectively. Angular deviation and distance among the TEA, CA and FEA were measured.The TEA-FEA angular deviation was significantly larger than that of the CA-FEA in 3D and transverse plane (3.45° vs. 1.98°, p < 0.001; 2.72° vs. 1.19°, p = 0.002, but not in the coronal plane (1.61° vs. 0.83°, p = 0.076. The TEA-FEA distance was significantly greater than that of the CA-FEA in the medial side (6.7 mm vs. 1.9 mm, p < 0.001, but not in the lateral side (3.2 mm vs. 2.0 mm, p = 0.16.The CA is closer to the FEA compared with the TEA; it can better serve as an anatomical surrogate for the functional knee axis.

  8. Prophylactic cranial irradiation could improve overall survival in patients with extensive small cell lung cancer. A retrospective study

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Yi [Tsinghua University, Medical Center Tsinghua University, Beijing (China); Li, Jinyu; Hu, Yi; Lin, Zhi; Jiao, Shunchang [Chinese PLA General Hospital, Department of Medical Oncology, Beijing (China); Zhang, Yibao [Peking University Cancer Hospital and Institute, Key laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Radiotherapy, Beijing (China); Zhao, Zhifei [Chinese PLA General Hospital, Department of Radiation Oncology, Beijing (China)

    2016-12-15

    To evaluate the effect of prophylactic cranial irradiation (PCI) on overall survival (OS) in patients with extensive small cell lung cancer (ESCLC). Between April 2005 and May 2014, 204 patients with ESCLC who had any response (according to RECIST 1.1) to initial chemotherapy were reviewed. All patients had undergone appropriate imaging tests to exclude brain metastases before initial chemotherapy. PCI was performed on 45 patients (22.1 %) and the remaining patients (77.9 %) received no such treatment (control group). Primary endpoint was OS. The incidence of brain metastases, brain metastases-free survival (BMFS), and adverse effects were also evaluated. Survival data of the 204 patients were analyzed statistically. PCI significantly prolonged median OS from 12.6 to 16.5 months as compared to the control group (hazard ratio, HR, 0.63; 95 % confidence interval, CI, 0.41 to 0.96; p = 0.033). PCI significantly lowered the risk of brain metastases (HR 0.48; 95 % CI 0.30 to 0.76; p = 0.001). The 1-year incidence of brain metastases was 17.1 and 55.9 % in the PCI and control group, respectively. PCI significantly correlated with the increased median BMFS (p = 0.002). Additionally, multivariate analyses demonstrated that PCI was a favorable independent predictor of OS, BMFS, and the incidence of brain metastases. Acute and chronic adverse effects were generally low grade and well tolerated in patients receiving PCI. PCI after any response to initial chemotherapy significantly improved OS of ESCLC patients analyzed in this study. (orig.) [German] Beurteilung des Effekts der prophylaktischen kranialen Bestrahlung (PCI) auf das Gesamtueberleben (OS) bei Patienten mit ausgedehntem kleinzelligem Lungenkarzinom (ESCLC). Zwischen April 2005 und Mai 2014 wurden 204 Patienten mit ESCLC nach Ansprechen auf eine initiale Chemotherapie (gemaess RECIST 1.1) untersucht. Vor der Chemotherapie wurden bei allen Patienten Untersuchungen mit entsprechenden Bildgebungsverfahren

  9. Three-year outcomes of individualized ranibizumab treatment in patients with diabetic macular edema : the RESTORE extension study

    NARCIS (Netherlands)

    Schmidt-Erfurth, Ursula; Lang, Gabriele E; Holz, Frank G; Schlingemann, Reinier O; Lanzetta, Paolo; Massin, Pascale; Gerstner, Ortrud; Bouazza, Abdelkader Si; Shen, Haige; Osborne, Aaron; Mitchell, Paul

    2014-01-01

    OBJECTIVE: To evaluate long-term efficacy and safety profiles during 3 years of individualized ranibizumab treatment in patients with visual impairment due to diabetic macular edema (DME). DESIGN: Phase IIIb, multicenter, 12-month, randomized core study and 24-month open-label extension study. PARTI

  10. Identification of the Competencies Needed to Apply Social Marketing to Extension Programming: Results of a Delphi Study

    Science.gov (United States)

    Warner, Laura A.; Stubbs, Eric; Murphrey, Theresa Pesl; Huynh, Phuong

    2016-01-01

    The purpose of this study was to identify the specific competencies needed to apply social marketing, a promising approach to behavior change, to Extension programming. A modified Delphi study was used to achieve group consensus among a panel of experts on the skills, characteristics, and knowledge needed to successfully apply this behavior change…

  11. Spatial Double Generalized Beta Regression Models: Extensions and Application to Study Quality of Education in Colombia

    Science.gov (United States)

    Cepeda-Cuervo, Edilberto; Núñez-Antón, Vicente

    2013-01-01

    In this article, a proposed Bayesian extension of the generalized beta spatial regression models is applied to the analysis of the quality of education in Colombia. We briefly revise the beta distribution and describe the joint modeling approach for the mean and dispersion parameters in the spatial regression models' setting. Finally, we…

  12. A Study of Informal Learning among University of Wyoming Extension Educators

    Science.gov (United States)

    Skrabut, Stanley A.

    2013-01-01

    University of Wyoming Extension educators are often hired because of their subject matter expertise; yet, they must still develop education skills as well as learn to use various and ever-changing technologies. This research was conducted to understand what impact guided instruction on informal learning concepts and methods had on UW Extension…

  13. Spatial Double Generalized Beta Regression Models: Extensions and Application to Study Quality of Education in Colombia

    Science.gov (United States)

    Cepeda-Cuervo, Edilberto; Núñez-Antón, Vicente

    2013-01-01

    In this article, a proposed Bayesian extension of the generalized beta spatial regression models is applied to the analysis of the quality of education in Colombia. We briefly revise the beta distribution and describe the joint modeling approach for the mean and dispersion parameters in the spatial regression models' setting. Finally, we motivate…

  14. A study on the optimization of plant life extension and decommissioning for the improvement of economy in nuclear power plant

    Energy Technology Data Exchange (ETDEWEB)

    Shin, Jae In; Jung, K. J.; Chung, U. S.; Baik, S. T.; Park, S. K.; Lee, D. G.; Kim, H. R.; Park, B. Y

    2000-01-01

    Fundamentals on the plan, the national policy, the safety securities for the life extension of the nuclear power plant was established from the domestic/abroad documents and case studies in relation with the life extension and decommissioning of the nuclear power plant. Concerning the decommissioning of the nuclear power plant, the management according to decommissioning stages was analyzed by the investigation of the domestic/abroad standard of the decommissioning (decontamination. dismantling) technology and regulation. Moreover, the study on the cost estimation method has been carried out for the decommissioning of the nuclear power plant. (author)

  15. Applications of Extensive Green-roof Systems in Contributing to Sustainable Development in Densely Populated Cities: a Hong Kong Study

    Directory of Open Access Journals (Sweden)

    Xiaoling Zhang

    2011-03-01

    Full Text Available Developed cities such as Hong Kong are usually densely populated. Since the land is limited, high-rise buildings are constructed. When the building height becomes higher, air flow is reduced and heat is trapped among high-rise buildings. Air temperature will be greatly increased and air pollution becomes a serious problem. This creates a walled building problem. To reduce air temperature caused by the wall-effects, various methods have been developed in the previous studies. One typical method is the use of green roof systems. The application of extensive green roofs on the existing building rooftops has been recommended in Hong Kong since 2001. The advantage of this practice is that no additional floor area is required and it can also improve urban greenery. Although a green roof system has been introduced and adopted in Hong Kong since 2001, the emphasis is mainly given to the application of intensive green roofs for podium garden instead of extensive green roofs. It is considered valuable and necessary of the extensive green roofs for the buildings. This paper investigates the current practice of using extensive green roofs in Hong Kong. The constraints in applying extensive green roofs are investigated, which leads to studying the solutions for mitigating these constraints and improving the future development of the implementation.

  16. A study of storage life extension for high performance chemically amplified resist coated blanks

    Science.gov (United States)

    Yang, Sin-Ju; Seo, Sung-Min; Ko, Sang-Hoon; Cha, Han-Sun; Kang, Geung-Won; Nam, Kee-Soo; Seo, Woong-Won; Jung, Woo-Kyun; Cho, Hyun-Kyoon; Kim, Jin-Min; Choi, Sang-Soo

    2005-06-01

    The importance of advanced e-beam writing system and chemically amplified resist (CAR) coated blank is increasing gradually in high-end grade photomask manufacture according to CD embodiment of 90 nm and beyond technology node requiring because of the shrinkage of design rule in the semiconductor industry. However, many studies have been reported that CAR has several troubles and especially, CAR sensitivity change is occurred by airborne molecular contamination (AMC). So, the storage life of CAR coated blank is shortened. This problem may cause the difficulty of high-end grade photomask manufacture because it is hard to secure stable mean to target (MTT) and CD uniformity by sensitivity change, T-top profile and footing profile. Therefore, the purpose of this paper is to investigate the storage life extension for high performance CAR coated blank through improvement of the packing materials. Firstly, a variety of packing materials were collected and the selected packing materials were analyzed by Automatic Thermal Desorption Gas Chromatograph/Mass Spectrometer (ATD GC/MS) and Ion Chromatograph (IC) to examine AMC generated from the packing materials. As a result, molecular condensables such as alcohols, hydrocarbons and fatty acids were detected and molecular acids and molecular bases those are NH4+, Cl-, NOx- and SOx- were also detected from the packing materials, respectively. From the above results, we selected the best packing materials which generated the least AMC and the worst packing materials which generated the most AMC. Additionally, we verified photomask process with CAR coated blanks which were packed with those packing materials with post coating delay (PCD) by 50 kV e-beam writing system. In consequence, dose to clear (DTC) showed 4.6 μC/cm2 at 0 day PCD for both of the best and the worst packing materials of CAR coated blank. After 90 days PCD, DTC variation was only 0.4 μC/cm2 for the best packing materials, but DTC variation of 4.0 μC/cm2

  17. Theoretical parametric study of the relative advantages of winglets and wing-tip extensions

    Science.gov (United States)

    Heyson, H. H.; Riebe, G. D.; Fulton, C. L.

    1977-01-01

    It was found that for identical increases in bending moment, a winglet provides a greater gain in induced efficiency than a tip extension. Winglet toe-in angle allows design trades between efficiency and root moment. A winglet showed the greatest benefit when the wing loads were heavy near the tip. Washout diminished the benefit of either tip modification, and the gain in induced efficiency became a function of lift coefficient; heavy wing loadings obtained the greatest benefit from a winglet, and low speed performance was enhanced even more than cruise performance. Both induced efficiency and bending moment increased with winglet length and outward cant. The benefit of a winglet relative to a tip extension was greatest for a nearly vertical winglet. Root bending moment was proportional to the minimum weight of bending material required in the wing; it is a valid index of the impact of tip modifications on a new wing design.

  18. Micro-computed tomography study of the abnormal osseous extensions of sella turcica.

    Science.gov (United States)

    Skrzat, J; Kozerska, M; Wróbel, A

    2014-02-01

    The paper presents anatomical considerations on the abnormal ossification, which occurred around the dorsum of the sella turcica in the human skull of the female individual. Probably the morphological alterations of the sellar region were associated with extensive heterotopic ossification of the dura mater attached to the dorsum of the sella turcica and the posterior clinoid processes. The analysis of gray values of the voxels representing the areas of abnormal ossification indicated on variation in bone density in the entire sample. We have established that the highest mineralisation of bony tissue occurred in the marginal parts of the osseous extensions deriving from the posterior clinoid processes. The ossified parts of dura mater attached to the posterior clinoid processes showed significantly higher content of the hydroxyapatite (1.9 g/cm3) than the dorsum of the sella turcica (1.0 g/cm3).

  19. EXTENSION THROUGH ANALOGY A USEFUL METHOD IN THE STUDY OF DISPARITIES

    Directory of Open Access Journals (Sweden)

    Viorica PUSCACIU

    2006-01-01

    Full Text Available The method of extension through analogy is, in our view, useful for comparisons between miscellaneous economical indicators belonging to the same structure, also between indicators which belongs to various economical areas like cities, regions, countries. Taking into account Romania’s admission to the European Union, this method would establish the extant temporary disparities and would impress those responsible in the political economy. As a novelty we present it inthe context of square trends.

  20. Agri-technologies and travelling facts: case study of extension education in Tamil Nadu, India

    OpenAIRE

    2008-01-01

    This paper is motivated by two broad questions: how is technology transferred from academia to non-academic domains, and how well do facts within these technologies travel? These questions are explored in the context of a particular extension education program in Tamil Nadu, south India. The paper explores the extent to which fertigation technologies (drip irrigation) and other farm and postharvest technologies travelled from the Tamil Nadu Agricultural University to the farming community in ...

  1. A Theoretical Extension of the Technology Acceptance Model: Four Longitudinal Field Studies

    OpenAIRE

    Viswanath Venkatesh; Fred D. Davis

    2000-01-01

    The present research develops and tests a theoretical extension of the Technology Acceptance Model (TAM) that explains perceived usefulness and usage intentions in terms of social influence and cognitive instrumental processes. The extended model, referred to as TAM2, was tested using longitudinal data collected regarding four different systems at four organizations (N = 156), two involving voluntary usage and two involving mandatory usage. Model constructs were measured at three points in ti...

  2. Controlled categorisation processing in brand extension evaluation by Indo-European language speakers. An ERP study.

    Science.gov (United States)

    Fudali-Czyż, Agnieszka; Ratomska, Marta; Cudo, Andrzej; Francuz, Piotr; Kopiś, Natalia; Tużnik, Przemysław

    2016-08-15

    The purpose of our experiment was to test event-related potentials (ERP) accompanying the process of brand extension evaluation in people speaking Indo-European languages. The experimental procedure consisted of sequential presentations of pairs of stimuli; namely, a beverage brand name and a product name. The products fell into the category of beverages (congruent trials) or clothes (incongruent trials). In the response condition (RC), the participants decided whether they accepted the product as an extension of the brand. In the no-response condition (NRC), the participants' task was to attend the stimuli and try to remember them. In the response condition, the amplitudes of the N270, P300 and N400 components were sensitive to incongruence between the product category and the previously presented brand. However, in the no-response condition, differences emerged only at the level of early P1 and P2 components. Our results suggest that, in people speaking one of the Indo-European languages, the process of categorisation in brand extension evaluation is not automatic.

  3. Detailed studies of the electron lateral distribution in extensive air showers with energies around 10(16) eV

    Science.gov (United States)

    Dzikowski, T.; Gawin, J.; Wdowczyk, J.

    1984-01-01

    Detailed studies have been performed of the electron lateral distribution in extensive air showers using the Lodz extensive air shower array. The showers were grouped according to their particle densities around 20 m from the core. The grouping was made in very narrow intervals of the densities. For every group of showers and for every distance interval /changing by 5 m/ histograms of the numbers of electron counters discharged have been obtained. The trays of G.M counters were located at following distances from the center of the triggering detectors array: 16 m, 76 m, 117 m, 137 m, 141 m and 147 m.

  4. On application of non—extensive statistical mechanics to studying ecological diversity

    Science.gov (United States)

    Van Xuan, Le; Lan, Nguyen Tri; Viet, Nguyen Ai

    2016-06-01

    The concept of Tsallis entropy provides an extension of thermodynamics and statistical physics. In the ecology, Tsallis entropy is proposed to be a new class of diversity indices Sq which covers many common diversity indices found in ecological literature. As a new statistical model for the Whittaker plots describing species abundance distribution, the truncated exponential distribution is used to calculate the diversity and evenness indices. The obtained results in new model are graphically compared with those in previous publication in the same field of interests, and shows a good agreement. A further development of a thermodynamic theory of ecological systems that is consistent with entropic approach of statistical physics is motivated.

  5. A comparison study of CORSIKA and COSMOS simulations for extensive air showers

    CERN Document Server

    Roh, Soonyoung; Ryu, Dongsu; Kang, Hyesung; Kasahara, Katsuaki; Kido, Eiji; Taketa, Akimichi

    2013-01-01

    Cosmic rays with energy exceeding ~ 10^{18} eV are referred to as ultra-high energy cosmic rays (UHECRs). Monte Carlo codes for extensive air shower (EAS) simulate the development of EASs initiated by UHECRs in the Earth's atmosphere. Experiments to detect UHECRs utilize EAS simulations to estimate their energy, arrival direction, and composition. In this paper, we compare EAS simulations with two different codes, CORSIKA and COSMOS, presenting quantities including the longitudinal distribution of particles, depth of shower maximum, kinetic energy distribution of particle at the ground, and energy deposited to the air. We then discuss implications of our results to UHECR experiments.

  6. The Safe Dates program: 1-year follow-up results.

    Science.gov (United States)

    Foshee, V A; Bauman, K E; Greene, W F; Koch, G G; Linder, G F; MacDougall, J E

    2000-01-01

    OBJECTIVES: An earlier report described desirable 1-month follow-up effects of the Safe Dates program on psychological, physical, and sexual dating violence. Mediators of the program-behavior relationship also were identified. The present report describes the 1-year follow-up effects of the Safe Dates program. METHODS: Fourteen schools were in the randomized experiment. Data were gathered by questionnaires in schools before program activities and 1 year after the program ended. RESULTS: The short-term behavioral effects had disappeared at 1 year, but effects on mediating variables such as dating violence norms, conflict management skills, and awareness of community services for dating violence were maintained. CONCLUSIONS: The findings are considered in the context of why program effects might have decayed and the possible role of boosters for effect maintenance. PMID:11029999

  7. Standardization of doctoral study in agricultural and extension education: is the field of study mature enough for achievement of the optimum degree of order?

    Science.gov (United States)

    Briers, G E; Lindner, J R; Shinn, G C; Wingenbach, G W; Baker, M T

    2010-01-01

    Agricultural and extension education--or some derivative name--is a field of study leading to the doctoral degree in universities around the world. Is there are body of knowledge or a taxonomy of the knowledge--e.g., a knowledge domain--that one should possess with a doctorate in agricultural and extension education? The purpose of this paper was to synthesize the work of researchers who attempted to define the field of study, with a taxonomy comprising the knowledge domains (standards) and knowledge objects--structured interrelated sets of data, knowledge, and wisdom--of the field of study. Doctoral study in agricultural and extension education needs a document that provides for rules and guidelines--rules and guidelines that in turn provide for common and repeated use--all leading to achievement of an optimum degree of order in the context of academic, scholarly, and professional practice in agricultural and extension education. Thus, one would know in broad categories the knowledge, skills, and abilities possessed by one who holds a doctoral degree in agricultural and extension education. That is, there would exist a standard for doctoral degrees in agricultural and extension education. A content analysis of three previous attempts to categorize knowledge in agricultural and extension education served as the primary technique to create a new taxonomy--or to confirm an existing taxonomy--for doctoral study in agricultural and extension education. The following coalesced as nine essential knowledge domains for a doctorate in agricultural and extension education: (1) history, philosophy, ethics, and policy; (2) agricultural/rural development; (3) organizational development and change management; (4) planning, needs assessment, and evaluation; (5) learning theory; (6) curriculum development and instructional design; (7) teaching methods and delivery strategies; (8) research methods and tools; and, (9) scholarship and communications.

  8. Glomus jugulare tumor with intra- and extracranial extension. A case report with MRI study

    Energy Technology Data Exchange (ETDEWEB)

    Morisako, Toshitaka; Goya, Tomokazu; Wakisaka, Shinichiro; Kinoshita, Kazuo

    1987-11-01

    A case of glomus jugulare tumor with intra- and extracranial extension is described. The patient was a 63-year-old woman who complained of gait and memory disturbances. On admission neurological examination revealed recent memory disturbance, left deafness, left XI, XIIth cranial nerve palsies, and slight ataxic gait. Roentgenogram of the skull showed an enlarged left jugular foramen with bone erosion. Plain X-ray computerized tomography scan (X-CT) indicated obstructive hydrocephalus and X-CT with contrast enhancement revealed a mass lesion in the left posterior cranial fossa extending through enlarged left jugular foramen to the extracranial space toward the level of C/sub 2/. Cerebral angiography demonstrated a large mass with blood supply from branches of left external carotid and vertebral arteries. The tumor stain was not remarkable. Left internal jugular vein was completely obstructed at the level of the second cervical vertebral body. Magnetic resonance imaging (MRI) clearly showed the tumor extending from the anterolateral portion to the second cervical vertebral body through the enlarged jugular foramen to the posterior cranial fossa. Brain stem and cerebellar hemisphere which were markedly compressed by the mass were clearly visualized. At first a ventriculo-peritoneal shunt was made and four weeks later subtotal removal of the tumor was undertaken. Histopathology of tumor specimen showed typical glomus jugulare tumor. MRI was considered to be very useful for the diagnosis and treatment of the glomus jugulare tumor with intra- and extracranial extension

  9. Hybrid Extensive Air Shower Detector Array at the University of Puebla to Study Cosmic Rays

    Science.gov (United States)

    Martínez, O.; Pérez, E.; Salazar, H.; Villaseñor, L.

    We describe the design of an extensive air shower detector array built in the Campus of the University of Puebla (located at 19°N, 90°W, 800 gcm -2) to measure the energy and arrival direction of primary cosmic rays with energies around 1015 eV. The array consists of 18 liquid scintillator detectors (12 in the first stage) and 6 water Cherenkov detectors (one of 10 m 2 cross section and five smaller ones of 1.86 m 2 cross section), distributed in a square grid with a detector spacing of 20 m over an area of 4000 m 2. In this paper we discuss the calibration and stability of the array, and discuss the capability of hybrid arrays, such as this one consisting of water Cherenkov and liquid scintillator detectors, to allow a separation of the electromagnetic and muon components of extensive air showers. This separation plays an important role in the determination of the mass and identity of the primary cosmic ray. This facility is also used to train students interested in the field of cosmic rays.

  10. Safety of a new extensively hydrolysed formula in children with cow's milk protein allergy: a double blind crossover study

    Directory of Open Access Journals (Sweden)

    Schaafsma Anne

    2002-10-01

    Full Text Available Abstract Background Formulae for infants with cow's milk protein allergy (CMA should be based on extensively hydrolysed protein. 'Extensively' however is not strictly defined. Differences in molecular weight and peptide chain length may affect its clinical outcome. We studied the safety of a new extensively hydrolysed casein based formula (Frisolac Allergycare®: FAC for children with IgE mediated CMA. Methods Thirty children, aged 1.5 – 14.8 years old (median 4.9 years with persistent CMA were enrolled in this double-blind reference product (Nutramigen®: NUT controlled crossover study. All had positive skin prick tests (SPT and IgE mediated allergy, showing immediate reactions after ingestion of small amounts of milk. Twenty-five children also had positive radio allergen sorbent tests (RAST to cow's milk. Formulae provided consisted of 80% elementary formula in combination with 20% reference or test product. Crossover periods lasted for two weeks. From both products molecular weight (MALDI-TOF method and HPLC and peptide chain length distribution (adapted Edman degradation were determined. Results Maximum molecular weights of NUT and FAC are 2.1 and 2.56 kDa, respectively. The contribution of free amino acids and small peptides Conclusions The new extensively hydrolysed casein-based formula (FAC can safely be used in children with IgE mediated cow's milk allergy.

  11. An Examination Some of Educational – Extension Factors Influencing Use of Transgenic Plants (Case Study: Ilam, Iran

    Directory of Open Access Journals (Sweden)

    Mohammad Bagher Arayesh

    2015-12-01

    Full Text Available The purpose of this study was to examine the effect of educational – extension factors on the use of transgenic plants. This study was conducted through a survey design. The research was an applied study type. The research method of this study is descriptive-correlation. Statistical population of the study consisted of all of biotechnology experts of Research Center of Agriculture of Ilam Province (N=63. Census method was used in this study. A questionnaire was the main tool which the face and content its validity was confirmed by panel of University Experts. Reliability Coefficient (Cronbach's alpha of the questionnaire was 92%. Results showed that the use of media (radio and TV was the most important factor in the use of transgenic plants. The result of Spearman correlation coefficients showed that, there was a significant relationship between the variables such as the use of communication media, communication with extension professionals, and scientific rank of professional with use of transgenic plants. Multiple regression analysis results showed that varriables like scientific rank, relationship with extension professionals and mass media have positive effect on the dependent variable of application of transgenic plants, describing 53.2% of the changes of the mentioned dependent variable.

  12. Bioassay, isolation and studies on the mechanism of action of neurite extension factor

    Science.gov (United States)

    Kligman, D.

    1984-01-01

    The identification and purification of molecules active in promoting neurite outgrowth requires a sensitive reproducible bioassay. A quantitative bioassay was utilized to purify a neurite extension factor (NEF) based on counting the number of phase bright neurons with processes at least equal to one cell body diameter after 20 hrs. in culture is defined, serum free medium. Using a combination of heat treatment DEAE cellulose chromatography and gel filtration, an acidic protein of M sub r = 75,000 was highly purified. Upon reduction, it yields subunits of M sub r = 37,000. Purified fractions are active half maximally at 100 ng/ml in inducing neurite outgrowth in this bioassay. Currently, monoclonal antibodies to NEF are being produced. Female Balb C mice were immunized with the antigen and fusions with mouse myeloma cells will be performed to yield hybridoma cells.

  13. The Study and Simulation of Multi-interface Extension for OLSR Protocol

    Directory of Open Access Journals (Sweden)

    Zhong Hui

    2016-01-01

    Full Text Available The way to improve the performance of the throughput in the wireless Mesh network is nodes with multiple interfaces. In view of the problem of multi-interface multi-channel extension for OLSR protocol, multi–interface multi-channel OLSR protocol is proposed. Nodes can have multiple network interfaces, but each node has only one IP, using the index of interface to distinguish the multiple interfaces of the node. Selected the receiving interface according to the channel, modified the message delivery method and introduces the protocol implementation and technology. Finally, the simulation is carried out by using the extended NS2. Simulation results show that extended OLSR protocol has high network performance, and improve the network throughput. What is new and original in this paper is adding multiple physical interface support for proactive protocol OLSR.

  14. Regularized Risk Minimization by Nesterov's Accelerated Gradient Methods: Algorithmic Extensions and Empirical Studies

    CERN Document Server

    Zhang, Xinhua; Vishwanathan, S V N

    2010-01-01

    Nesterov's accelerated gradient methods (AGM) have been successfully applied in many machine learning areas. However, their empirical performance on training max-margin models has been inferior to existing specialized solvers. In this paper, we first extend AGM to strongly convex and composite objective functions with Bregman style prox-functions. Our unifying framework covers both the $\\infty$-memory and 1-memory styles of AGM, tunes the Lipschiz constant adaptively, and bounds the duality gap. Then we demonstrate various ways to apply this framework of methods to a wide range of machine learning problems. Emphasis will be given on their rate of convergence and how to efficiently compute the gradient and optimize the models. The experimental results show that with our extensions AGM outperforms state-of-the-art solvers on max-margin models.

  15. Site directed spin labeling studies of Escherichia coli dihydroorotate dehydrogenase N-terminal extension

    Energy Technology Data Exchange (ETDEWEB)

    Couto, Sheila G. [Instituto de Fisica de Sao Carlos, Universidade de Sao Paulo, Av. Trabalhador Sao-carlense 400, C.P. 369, 13560-970, Sao Carlos, SP (Brazil); Grupo de Biofisica e Fisica Aplicada a Medicina, Instituto de Fisica, Universidade Federal de Goias, Campus Samambaia, C.P. 131, 74001-970, Goiania, GO (Brazil); Cristina Nonato, M. [Laboratorio de Cristalografia de Proteinas, Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Universidade de Sao Paulo, Av. do Cafe S/N, 14040-903, Ribeirao Preto, SP (Brazil); Costa-Filho, Antonio J., E-mail: ajcosta@ffclrp.usp.br [Instituto de Fisica de Sao Carlos, Universidade de Sao Paulo, Av. Trabalhador Sao-carlense 400, C.P. 369, 13560-970, Sao Carlos, SP (Brazil); Departamento de Fisica, Faculdade de Filosofia, Ciencias e Letras de Ribeirao Preto, Av. Bandeirantes 3900, 14040-901, Ribeirao Preto, SP (Brazil)

    2011-10-28

    Highlights: Black-Right-Pointing-Pointer EcDHODH is a membrane-associated enzyme and a promising target for drug design. Black-Right-Pointing-Pointer Enzyme's N-terminal extension is responsible for membrane association. Black-Right-Pointing-Pointer N-terminal works as a molecular lid regulating access to the protein interior. -- Abstract: Dihydroorotate dehydrogenases (DHODHs) are enzymes that catalyze the fourth step of the de novo synthesis of pyrimidine nucleotides. In this reaction, DHODH converts dihydroorotate to orotate, using a flavine mononucleotide as a cofactor. Since the synthesis of nucleotides has different pathways in mammals as compared to parasites, DHODH has gained much attention as a promising target for drug design. Escherichia coli DHODH (EcDHODH) is a family 2 DHODH that interacts with cell membranes in order to promote catalysis. The membrane association is supposedly made via an extension found in the enzyme's N-terminal. In the present work, we used site directed spin labeling (SDSL) to specifically place a magnetic probe at positions 2, 5, 19, and 21 within the N-terminal and thus monitor, by using Electron Spin Resonance (ESR), dynamics and structural changes in this region in the presence of a membrane model system. Overall, our ESR spectra show that the N-terminal indeed binds to membranes and that it experiences a somewhat high flexibility that could be related to the role of this region as a molecular lid controlling the entrance of the enzyme's active site and thus allowing the enzyme to give access to quinones that are dispersed in the membrane and that are necessary for the catalysis.

  16. Extensive study of HD 25558, a long-period double-lined binary with two SPB components

    OpenAIRE

    Sodor, A.; De Cat, P.; Wright, D J; Neiner, C.; Briquet, M.; Lampens, P.; Dukes, R. J.; Henry, G. W.; Williamson, M.H.; Brunsden, E.; Pollard, K.R.; Cottrell, P. L.; Maisonneuve, F.; Kilmartin, P.M.; Matthews, J

    2014-01-01

    We carried out an extensive observational study of the Slowly Pulsating B (SPB) star, HD 25558. The ~2000 spectra obtained at different observatories, the ground-based and MOST satellite light curves revealed that this object is a double-lined spectroscopic binary with an orbital period of about 9 years. The observations do not allow the inference of an orbital solution. We determined the physical parameters of the components, and found that both lie within the SPB instability strip. Accordin...

  17. Study of Thorium-Plutonium Fuel for Possible Operating Cycle Extension in PWRs

    Directory of Open Access Journals (Sweden)

    Klara Insulander Björk

    2013-01-01

    Full Text Available Computer simulations have been carried out to investigate the possibility of extending operating cycle length in the Pressurised Water Reactor Ringhals 3 by the use of thorium-plutonium oxide fuel. The calculations have been carried out using tools and methods that are normally employed for reload design and safety evaluation in Ringhals 3. The 3-batch reload scheme and the power level have been kept unchanged, and a normal uranium oxide fuel assembly designed for a 12-month operating cycle in this reactor is used as a reference. The use of plutonium as the fissile component reduces the worth of control rods and soluble boron, which makes it necessary to modify the control systems. The delayed neutron fraction is low compared with the reference, but simulations and qualitative assessments of relevant transients indicate that the reactor could still be operated safely. Differences in reactivity coefficients are mainly beneficial for the outcome of transient simulations for the thorium based fuel. A 50% extension of the current 12-month operating cycle length should be possible with thorium-plutonium mixed oxide fuel, given an upgrade of the control systems. More detailed simulations have to be carried out for some transients in order to confirm the qualitative reasoning presented.

  18. Successful liver transplantation in babies under 1 year.

    OpenAIRE

    Beath, S V; Brook, G D; Kelly, D. A.; Cash, A J; McMaster, P; Mayer, A. D.; Buckels, J A

    1993-01-01

    OBJECTIVE--To review the outcome of liver transplantation in babies aged less than 1 year. DESIGN--Prospective evaluation of survival, clinical complications, and nutritional and developmental status before and one year after liver transplantation. SETTING--The Children's Hospital and Queen Elizabeth Hospital, Birmingham. SUBJECTS--All 25 babies who received liver transplantation from January 1989 to December 1992 were included. Median age was 9 months and median weight was 7.0 kg. Seven babi...

  19. Longitudinal profile of Nµ/Ne in extensive air showers: Implications for cosmic rays mass composition study

    Directory of Open Access Journals (Sweden)

    D Purmohammad

    2013-10-01

    Full Text Available Nµ/Ne, muon to electron population ratio in extensive air showers at high altitudes has been shown to be a suitable estimator of primary cosmic rays mass composition. This study is based on simulated extensive air showers. The Nµ/Ne ratio has been obtained in 100 depths from the top of the atmosphere to the sea level for different primary particle masses and energies. An empirical relation between cosmic ray atomic mass and Nµ/Ne has been obtained. The relation has then been used for estimation of atomic masses of progenitors of another set of simulated showers. Although the estimated masses are rough, the accuracy of the estimation improves with observation altitude.

  20. Application of non-extensive entropy to study of decoherence of RbCl quantum dot qubit: Tsallis entropy

    Science.gov (United States)

    Khordad, R.; Rastegar Sedehi, H. R.

    2017-01-01

    In this work, an electron which is strongly coupled to the LO-phonon in triangular quantum dots with Coulomb impurity is considered. The eigenenergies and eigenfunctions of the ground and the first-excited states of the electron are obtained using the Pekar variational method. We have studied decoherence of RbCl quantum dot qubit using the non-extensive entropy (Tsallis entropy) for different values of Coulomb impurity parameter, polaronic radius and electron-LO phonon coupling strength. Numerical analysis shows that the entropy has the oscillatory periodic evolution as function of the time due to the triangular form of the confinement. It is found that entropy oscillates under a standing wave envelope with increasing the Coulomb impurity parameter, electron-LO phonon coupling strength and polaronic radius. With reducing the non-extensive parameter q, the entropy increases and thereby we can miss information about the system.

  1. Outpatient treated burns in infants younger than 1 year in Helsinki during 2005-2009.

    Science.gov (United States)

    Laitakari, Elina; Koljonen, Virve; Pyörälä, Sari; Rintala, Risto

    2014-05-01

    In general, voluminous data exists concerning burns in children, but the data focusing specially on children less than 1 year of age is sporadic. We therefore focused on examining the special features of burns in children less than 1 year of age. A retrospective study of all outpatient treated burn patients burns, representing 15% of all pediatric burns during the study period. The majority was male and aged 9-12 months. Most of the burns occurred at home, and in most cases a caregiver was present in the injury room. Scalds were the most common type of injury followed by contact burns. The most common source of scald was from cups containing hot drink, and the most common source of contact burn was hot stoves or oven doors. Special attention needs to be targeted toward the prevention of burns in children less than 1 year of age. The majority of the injuries could have been prevented with more vigilance.

  2. Empirical Studies on Legitimation Strategies: A Case for International Business Research Extension

    DEFF Research Database (Denmark)

    Turcan, Romeo V.; Marinova, Svetla Trifonova; Rana, Mohammad Bakhtiar

    2012-01-01

    The paper focuses on legitimation and legitimation strategies applied by companies. Following the process of systematic review, we analyze empirical studies exploring legitimation and legitimation strategies from different theoretical perspectives. Using the key findings by reconnoitering and com...

  3. Magnetic studies over the northern extension of the Prathap ridge complex, eastern Arabian sea

    Digital Repository Service at National Institute of Oceanography (India)

    Krishna, K.S.; Murty, G.P.S.; Srinivas, K.; Rao, D.G.

    studies, constrainEd. by seismic results, determine the varied nature and depth to the top of the causative basement bodies. Similarities of the geophysical signatures of the ridges and their structural resemblance perhaps point to their common origin...

  4. STrengthening the REporting of Genetic Association Studies (STREGA: an extension of the STROBE statement.

    Directory of Open Access Journals (Sweden)

    Julian Little

    2009-02-01

    Full Text Available Making sense of rapidly evolving evidence on genetic associations is crucial to making genuine advances in human genomics and the eventual integration of this information in the practice of medicine and public health. Assessment of the strengths and weaknesses of this evidence, and hence the ability to synthesize it, has been limited by inadequate reporting of results. The STrengthening the REporting of Genetic Association studies (STREGA initiative builds on the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE Statement and provides additions to 12 of the 22 items on the STROBE checklist. The additions concern population stratification, genotyping errors, modelling haplotype variation, Hardy-Weinberg equilibrium, replication, selection of participants, rationale for choice of genes and variants, treatment effects in studying quantitative traits, statistical methods, relatedness, reporting of descriptive and outcome data, and the volume of data issues that are important to consider in genetic association studies. The STREGA recommendations do not prescribe or dictate how a genetic association study should be designed but seek to enhance the transparency of its reporting, regardless of choices made during design, conduct, or analysis.

  5. Metabolomics as an extension of proteomic analysis: study of acute kidney injury.

    Science.gov (United States)

    Portilla, Didier; Schnackenberg, Laura; Beger, Richard D

    2007-11-01

    Although proteomics studies the global expression of proteins, metabolomics characterizes and quantifies their end products: the metabolites, produced by an organism under a certain set of conditions. From this perspective it is apparent that proteomics and metabolomics are complementary and when joined allow a fuller appreciation of an organism's phenotype. Our studies using (1)H-nuclear magnetic resonance spectroscopic analysis showed the presence of glucose, amino acids, and trichloroacetic acid cycle metabolites in the urine after 48 hours of cisplatin administration. These metabolic alterations precede changes in serum creatinine. Biochemical studies confirmed the presence of glucosuria, but also showed the accumulation of nonesterified fatty acids, and triglycerides in serum, urine, and kidney tissue, despite increased levels of plasma insulin. These metabolic alterations were ameliorated by the use of fibrates. We propose that the injury-induced metabolic profile may be used as a biomarker of cisplatin-induced nephrotoxicity. These studies serve to illustrate that metabolomic studies add insight into pathophysiology not provided by proteomic analysis alone.

  6. STrengthening the REporting of Genetic Association Studies (STREGA – An Extension of the STROBE Statement

    Directory of Open Access Journals (Sweden)

    Julian Little

    2009-09-01

    Full Text Available Making sense of rapidly evolving evidence on genetic associations is crucial to making genuine advances in human genomics and the eventual integration of this information in the practice of medicine and public health. Assessment of the strengths and weaknesses of this evidence, and hence the ability to synthesize it, has been limited by inadequate reporting of results. The STrengthening the REporting of Genetic Association studies (STREGA initiative builds on the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE Statement and provides additions to 12 of the 22 items on the STROBE checklist. The additions concern population stratification, genotyping errors, modelling haplotype variation, Hardy-Weinberg equilibrium, replication, selection of participants, rationale for choice of genes and variants, treatment effects in studying quantitative traits, statistical methods, relatedness, reporting of descriptive and outcome data, and the volume of data issues that are important to consider in genetic association studies. The STREGA recommendations do not prescribe or dictate how a genetic association study should be designed but seek to enhance the transparency of its reporting, regardless of choices made during design, conduct, or analysis.

  7. Generalisation and extension of a web-based data collection system for clinical studies using Java and CORBA.

    Science.gov (United States)

    Eich, H P; Ohmann, C

    1999-01-01

    Inadequate informatical support of multi-centre clinical trials lead to pure quality. In order to support a multi-centre clinical trial a data collection via WWW and Internet based on Java has been developed. In this study a generalization and extension of this prototype has been performed. The prototype has been applied to another clinical trial and a knowledge server based on C+t has been integrated via CORBA. The investigation and implementation of security aspects of web-based data collection is now under evaluation.

  8. Extensive simulation studies on the reconstructed image resolution of a position sensitive detector based on pixelated CdTe crystals

    CERN Document Server

    Zachariadou, K; Kaissas, I; Seferlis, S; Lambropoulos, C; Loukas, D; Potiriadis, C

    2011-01-01

    We present results on the reconstructed image resolution of a position sensitive radiation instrument (COCAE) based on extensive simulation studies. The reconstructed image resolution has been investigated in a wide range of incident photon energies emitted by point-like sources located at different source-to-detector distances on and off the detector's symmetry axis. The ability of the detector to distinguish multiple radioactive sources observed simultaneously is investigating by simulating point-like sources of different energies located on and off the detector's symmetry axis and at different positions

  9. A simple extension of contraction theory to study incremental stability properties

    DEFF Research Database (Denmark)

    Jouffroy, Jerome

    Contraction theory is a recent tool enabling to study the stability of nonlinear systems trajectories with respect to one another, and therefore belongs to the class of incremental stability methods. In this paper, we extend the original definition of contraction theory to incorporate...

  10. An Extension Landau-Lifshitz Model in Studying Soft Ferromagnetic Films

    Institute of Scientific and Technical Information of China (English)

    Jing-na Li; Xiao-feng Wang; Zheng-an Yao

    2007-01-01

    In this paper, we propose a model in studying soft ferromagnetic films, which is readily accessible experimentally. By using penalty approximation and compensated compactness, we prove that the dynamical equation in thin film has a local weak solution. Moreover, the corresponding linear equation is also dealt with in great detail.

  11. Method Modification Study for the Thermo Scientific SureTect™ Listeria Species Assay-Matrix Extension.

    Science.gov (United States)

    Cloke, Jonathan; Evans, Katharine; Crabtree, David; Hughes, Annette; Simpson, Helen; Holopainen, Jani; Wickstrand, Nina; Kauppinen, Mikko; Leon-Velarde, Carlos; Larson, Nathan; Dave, Keron; Chen, Yi; Ryser, Elliot; Carter, Mark

    2016-01-01

    The Thermo Scientific™ SureTect™ Listeria species assay is a new real-time PCR assay for the detection of all species of Listeria in food and environmental samples. The assay was originally certified as Performance Tested Methods(SM) (PTM) 071304 in 2013. This report details the method modification study undertaken to extend the performance claims of the assay for matrixes of raw ground turkey, raw ground pork, bagged lettuce, raw pork sausages, pasteurized 2% fat milk, raw cod, pasteurized brie cheese, and ice cream. The method modification study was conducted using the AOAC Research Institute (RI) PTM program to validate the SureTect PCR assay in comparison to the reference method detailed in ISO 11290-1:1996 including amendment 1:2004. All matrixes were tested by Thermo Fisher Scientific (Basingstoke, United Kingdom). In addition, three matrixes (raw cod, bagged lettuce, and pasteurized brie cheese) were analyzed independently as part of the AOAC RI-controlled independent laboratory study by the University of Guelph, Canada. Using probability of detection statistical analysis, there was no significant difference in the performance between the SureTect assay and the International Organization for Standardization reference method for any of the matrixes analyzed in this study.

  12. What reassurances do the community need regarding life extension? Evidence from studies of community attitudes and an analysis of film portrayals.

    Science.gov (United States)

    Underwood, Mair

    2014-04-01

    It is increasingly recognized that community attitudes impact on the research trajectory, entry, and reception of new biotechnologies. Yet biogerontologists have generally been dismissive of public concerns about life extension. There is some evidence that biogerontological research agendas have not been communicated effectively, with studies finding that most community members have little or no knowledge of life extension research. In the absence of knowledge, community members' attitudes may well be shaped by issues raised in popular portrayals of life extension (e.g., in movies). To investigate how popular portrayals of life extension may influence community attitudes, I conducted an analysis of 19 films depicting human life extension across different genres. I focussed on how the pursuit of life extension was depicted, how life extension was achieved, the levels of interest in life extension shown by characters in the films, and the experiences of extended life depicted both at an individual and societal level. This paper compares the results of this analysis with the literature on community attitudes to life extension and makes recommendations about the issues in which the public may require reassurance if they are to support and accept life extension technologies.

  13. Extensive studies of MRS APDs for plastic scintillator muon veto detectors of cryogenic experiments

    Energy Technology Data Exchange (ETDEWEB)

    Falkenstein, R., E-mail: falkenst@pit.physik.uni-tuebingen.de [Kepler Center for Astro and Particle Physics, University of Tuebingen, Auf der Morgenstelle 14, 72076 Tuebingen (Germany); Bezrukov, L.B. [Institute for Nuclear Research of RAS, Moscow (Russian Federation); Freund, K. [Kepler Center for Astro and Particle Physics, University of Tuebingen, Auf der Morgenstelle 14, 72076 Tuebingen (Germany); Golovin, A.V.; Golovin, V.M. [Centre for Perspective Technology and Apparatus, Moscow (Russian Federation); Grabmayr, P.; Jochum, J. [Kepler Center for Astro and Particle Physics, University of Tuebingen, Auf der Morgenstelle 14, 72076 Tuebingen (Germany); Lubsandorzhiev, B.K. [Kepler Center for Astro and Particle Physics, University of Tuebingen, Auf der Morgenstelle 14, 72076 Tuebingen (Germany); Institute for Nuclear Research of RAS, Moscow (Russian Federation); Lubsandorzhiev, N.B.; Poleshuk, R.V. [Institute for Nuclear Research of RAS, Moscow (Russian Federation); Polyansky, I.N. [Centre for Perspective Technology and Apparatus, Moscow (Russian Federation); Ritter, F.; Sailer, C. [Kepler Center for Astro and Particle Physics, University of Tuebingen, Auf der Morgenstelle 14, 72076 Tuebingen (Germany); Shaibonov, B.A.M. [Institute for Nuclear Research of RAS, Moscow (Russian Federation)

    2012-12-11

    Low background experiments need active muon veto detectors to shield them from cosmic muons. Plastic scintillator panels with WLS fiber and multi-pixel Geiger-mode avalanche photodiodes readout are widely used in such experiments due to their compactness and robustness. In this paper, results from the study of the basic MRS APD parameters, such as breakdown voltages, quenching resistors, internal gain and dark count rates are presented, as well as temperature dependencies of some of these parameters. In a small fraction of the MRS APDs, some strange dips in the I-V curves just preceding the breakdown voltage point have been observed.

  14. Two-Dimensional Numerical Modeling of Intracontinental Extension: A Case Study Of the Baikal Rift Formation

    DEFF Research Database (Denmark)

    Yang, H.; Chemia, Zurab; Artemieva, Irina

    and geophysical studies, the geodynamic origin and evolution of the BRZ is still debated. We applytwo-dimensional finite difference code to model the lithosphere-scale de-formation in several locations across the strike of the Baikal Rift zone. The model se-tup takes an advantage of regional geophysical models...... to determinethe set of parameters that may define regional li-thosphere evolution towards the present lithosphere structure, which we further con-trol by gravity data, regional volcanism, and the age of the BRZ formation. We dem-onstrate the roleof pre-existing faults on the BRZ evolution and on formation of "off...

  15. Nightmares as predictors of suicide: an extension study including war veterans

    Science.gov (United States)

    Sandman, Nils; Valli, Katja; Kronholm, Erkki; Vartiainen, Erkki; Laatikainen, Tiina; Paunio, Tiina

    2017-01-01

    Nightmares are intensive dreams with negative emotional tone. Frequent nightmares can pose a serious clinical problem and in 2001, Tanskanen et al. found that nightmares increase the risk of suicide. However, the dataset used by these authors included war veterans in whom nightmare frequency - and possibly also suicide risk - is elevated. Therefore, re-examination of the association between nightmares and suicide in these data is warranted. We investigated the relationship between nightmares and suicide both in the general population and war veterans in Finnish National FINRISK Study from the years 1972 to 2012, a dataset overlapping with the one used in the study by Tanskanen et al. Our data comprise 71,068 participants of whom 3139 are war veterans. Participants were followed from their survey participation until the end of 2014 or death. Suicides (N = 398) were identified from the National Causes of Death Register. Frequent nightmares increase the risk of suicide: The result of Tanskanen et al. holds even when war experiences are controlled for. Actually nightmares are not significantly associated with suicides among war veterans. These results support the role of nightmares as an independent risk factor for suicide instead of just being proxy for history of traumatic experiences. PMID:28294195

  16. Relationship of sleep disturbance and therapeutic effect of depression in elderly inpatients: an observational 1-year follow-up study%老年抑郁障碍患者睡眠紊乱与抑郁疗效关系的一年随访研究

    Institute of Scientific and Technical Information of China (English)

    孙新宇; 李涛; 程瑶; 高锦霞; 张卫华

    2015-01-01

    sleep disturbance in elderly inpatients with depression in the acute treatment duration and its association with 1-year outcome were observed,so as to give reference for reasonable treatment of sleep disturbance in the aged.Methods In an observationally naturalistic study,69 consecutive elderly inpatient with ICD-10 criteria for depressive disorders were included.The sleep disturbance was assessed with the Pittsburgh Sleep Quality Index (PSQI) at baseline,2-week,4-week treatment and 1-year follow-up,and total score of 8 or higher was defined as having sleep disturbance.The HAMD and HAMA for illness severity,and MMSE for cognitive functioning was assessed simuhaneously.At the 1-year follow-up,the Global Assessment Function (GAF) was used for assessing social functioning as well.Results The PSQI scores at baseline,2-week,3-week and 1-year follow-up were (15.4±3.8),(12.0±4.6),(9.4±4.3) and (8.5±4.7),and repeated measured variance of analysis showed the differences of scores between 2-week,4-week and baseline were statistically significant (F=48.85,40.92;both P<0.05),while the difference between 4-week and 1-year follow-up was not significant (F=1.86,P=0.178).At 2-and 4-week treatment,the rate of co-therapy of hypnotics was higher inpatients with sleep disturbance.The decreased rates ofPSQI score at 2-week was correlated to the decreased rate of HAMD score at 2-week (r=0.33,P=0.006) and 4-week (r=0.40; P=0.001),but not at 1-year follow-up (r=0.16,P=0.228).At 1-year follow-up,having sleep disturbance was significantly associated with higher HAMD score (OR=11.56,Wald X2=4.26; P<0.05),but the associations with HAMA,MMSE and GAF scores were not significant.Conclusion Sleep disturbance in the elderly inpatients with depression could be improved with effective antidepressant treatment,and improvement in early treatment phase could predict better therapeutic effect in the acute phase.The residual sleep disturbance at 1-year follow-up may be an important residual symptom of

  17. A study on the life extension of polymer materials under radiation environment

    Energy Technology Data Exchange (ETDEWEB)

    Park, K. J.; Park, S. W.; Cho, S. H.; Hong, S. S

    2000-12-01

    The object of this study is to improve the stability and the economic profit by reducing the radiation-induced degradation rate of polymer material used under the radiation environment. So far, the resistance to radiation-induced oxidation of a polymer has been improved by the stabilizers. They can play an important role in the anti-oxidants that interrupt the radical-mediated oxidation chain reaction. The stabilization effect could be larger than that achieved in an inert-atmosphere irradiation. Stabilization is a function of stabilizer concentration up to a certain threshold, but it is not further improved above this concentration. Beyond the threshold, the rate of radiation-induced oxidation goes up to the rate that is characteristic for the unstabilized polymer. To make up for this weakness, a technique depositing a thin layer of diamond-like carbon (DLC) on the polymer surface was developed for protecting the radiation-induced oxidation in the air.

  18. The unexpected outcomes of anti-aging, rejuvenation, and life extension studies: an origin of modern therapies.

    Science.gov (United States)

    Stambler, Ilia

    2014-06-01

    The search for life-extending interventions has been often perceived as a purely academic pursuit, or as an unorthodox medical enterprise, with little or no practical outcome. Yet, in fact, these studies, explicitly aiming to prolong human life, often constituted a formidable, though hardly ever acknowledged, motivation for biomedical research and discovery. At least several modern biomedical fields have originated directly from rejuvenation and life extension research: (1) Hormone replacement therapy was born in Charles-Edouard Brown-Séquard's rejuvenation experiments with animal gland extracts (1889). (2) Probiotic diets originated in Elie Metchnikoff's conception of radically prolonged "orthobiosis" (c. 1900). (3) The development of clinical endocrinology owed much to Eugen Steinach's "endocrine rejuvenation" operations (c. 1910s-1920s). (4) Tissue transplantations in humans (allografts and xenografts) were first widely performed in Serge Voronoff's "rejuvenation by grafting" experiments (c. 1910s-1920s). (5) Tissue engineering was pioneered during Alexis Carrel's work on cell and tissue immortalization (c. 1900-1920). (6) Cell therapy (and particularly human embryonic cell therapy) was first widely conducted by Paul Niehans for the purposes of rejuvenation as early as the 1930s. Thus, the pursuit of life extension and rejuvenation has constituted an inseparable and crucial element in the history of biomedicine. Notably, the common principle of these studies was the proactive maintenance of stable, long-term homeostasis of the entire organism.

  19. Do Extensive Rubber Plantation Influences Local Environment? A Case Study From Tripura, Northeast India.

    Directory of Open Access Journals (Sweden)

    Abhik Majumder

    2014-12-01

    Full Text Available Tripura is the second largest Natural Rubber (NR producing state of India. As most of the NR plantation in the state is rain dependent, it is observed that fluctuation in monsoon poses a serious threat to plantation growth of NR crops. The effect of such shift and fluctuation in climate ranges from surface and ground water level variation, air quality and soil preservation. At present no assessment is available to critically review the impact of large scale NR plantation on environment. In the present paper the effect and impact of annual rainfall deficit, depleted ground water level, average local atmospheric temperature variation and rainfall ground water recharge on NR plantation is studied for the state of Tripura. Considering the large scale accelerated NR plantation in the state, an attempt has been made to figure out the consequences related to water management. The multidirectional environmental threat to the state comprising annual rainfall deficit of 23.3 %, depleted ground water level and significant rise in average atmospheric temperature may severely hit the production of NR in the region. Moreover, the estimated requirement of water to produce ribbed smokes sheet (RSS will may escalate to more than 152140 kiloliters in the next ten years. The predicted amount of wastewater generated (directly or indirectly in RSS collection and industry processing effluents may cause large environmental issue due to their open disposal in many cases. Hence, also claims a threat to the rubber production and growth of the sector.

  20. Extensive X-ray variability studies of NGC 7314 using long XMM-Newton observations

    CERN Document Server

    Emmanoulopoulos, D; Vaughan, S; Papadakis, I E

    2016-01-01

    We present a detailed X-ray variability study of the low mass Active Galactic Nuclei (AGN) NGC 7314 using the two newly obtained XMM-Newton observations ($140$ and $130$ ks), together with two archival data sets of shorter duration ($45$ and $84$ ks). The relationship between the X-ray variability characteristics and other physical source properties (such as the black hole mass) are still relatively poorly defined, especially for low-mass AGN. We perform a new, fully analytical, power spectral density (PSD) model analysis method, which will be described in detail in a forthcoming paper, that takes into consideration the spectral distortions, caused by red-noise leak. We find that the PSD in the $0.5-10$ keV energy range, can be represented by a bending power-law with a bend around $6.7\\times10^{-5}$ Hz, having a slope of $0.51$ and $1.99$ below and above the bend, respectively. Adding our bend time-scale estimate, to an already published ensemble of estimates from several AGN, supports the idea that the bend ...

  1. Improving the Agronomy of Alyssum murale for Extensive Phytomining: A Five-Year Field Study.

    Science.gov (United States)

    Bani, Aida; Echevarria, Guillaume; Sulçe, Sulejman; Morel, Jean Louis

    2015-01-01

    Large ultramafic areas exist in Albania, which could be suitable for phytomining with native Alyssum murale. We undertook a five-year field experiment on an ultramafic Vertisol, aimed at optimizing a low-cost Ni-phytoextraction crop of A. murale which is adapted to the Balkans. The following aspects were studied on 18-m2 plots in natural conditions: the effect of (i) plant phenology and element distribution, (ii) plant nutrition and fertilization, (iii) plant cover and weed control and (iv), planting technique (natural cover vs. sown crop). The optimal harvest time was set at the mid-flowering stage when Ni concentration and biomass yield were highest. The application of N, P, and K fertilizers, and especially a split 100-kg ha(-1) N application, increased the density of A. murale against all other species. It significantly increased shoot yield, without reducing Ni concentration. In natural stands, the control of graminaceous weeds required the use of an anti-monocots herbicide. However, after the optimization of fertilization and harvest time, weed control procured little benefit. Finally, cropping sown A. murale was more efficient than enhancing native stands and gave higher biomass and phytoextraction yields; biomass yields progressively improved from 0.3 to 9.0 t ha(-1) and phytoextracted Ni increased from 1.7 to 105 kg ha(-1).

  2. BNP and NT-proBNP, Predictors of 1-Year Mortality in Nursing Home Residents

    NARCIS (Netherlands)

    Barents, Maaike; Hillege, Hans H. L.; van der Horst, Iwan C. C.; de Boer, Rudolph A.; Koster, J.; Muskiet, Frits A. J.; de Jongste, Mike J. L.

    2008-01-01

    Objectives: To investigate 1-year mortality prediction of B type natriuretic peptide (BNP) and N terminal-proBNP (NT-proBNP) in institutionalized elderly with multiple morbidities. Design: Prospective cross-sectional study. Setting: One nursing home. Participants: Ninety-three residents (mean age 81

  3. High 1-Year Complication Rate after Anterior Resection for Rectal Cancer

    NARCIS (Netherlands)

    Snijders, H. S.; Bakker, I. S.; Dekker, J. W. T.; Vermeer, T. A.; Consten, E. C. J.; Hoff, C.; Klaase, J. M.; Havenga, K.; Tollenaar, R. A. E. M.; Wiggers, T.

    2014-01-01

    Surgical options after anterior resection for rectal cancer include a primary anastomosis, anastomosis with a defunctioning stoma, and an end colostomy. This study describes short-term and 1-year outcomes of these different surgical strategies. Patients undergoing surgical resection for primary mid

  4. Management of Apical Periodontitis : Healing of Post-treatment Periapical Lesions Present 1 Year after Endodontic Treatment

    NARCIS (Netherlands)

    Zhang, Ming-Ming; Liang, Yu-Hong; Gao, Xue-Jun; Jiang, Lan; van der Sluis, Luc; Wu, Min-Kai

    2015-01-01

    Introduction: Post-treatment periapical lesions present 1 year after treatment may heal during the second year or later. The aim of this study was to assess second-year volumetric changes in post-treatment periapical radiolucencies detected 1 year after treatment. Methods: Post-treatment periapical

  5. Extensive X-ray variability studies of NGC 7314 using long XMM-Newton observations

    Science.gov (United States)

    Emmanoulopoulos, D.; McHardy, I. M.; Vaughan, S.; Papadakis, I. E.

    2016-08-01

    We present a detailed X-ray variability study of the low-mass active galactic nuclei (AGN) NGC 7314 using the two newly obtained XMM-Newton observations (140 and 130 ks), together with two archival data sets of shorter duration (45 and 84 ks). The relationship between the X-ray variability characteristics and other physical source properties (such as the black hole mass) are still relatively poorly defined, especially for low-mass AGN. We perform a new, fully analytical, power spectral density (PSD) model analysis method, which will be described in detail in a forthcoming paper, that takes into consideration the spectral distortions, caused by red-noise leak. We find that the PSD in the 0.5-10 keV energy range, can be represented by a bending power law with a bend around 6.7 × 10-5 Hz, having a slope of 0.51 and 1.99 below and above the bend, respectively. Adding our bend time-scale estimate, to an already published ensemble of estimates from several AGN, supports the idea that the bend time-scale depends linearly only on the black hole mass and not on the bolometric luminosity. Moreover, we find that as the energy range increases, the PSD normalization increases and there is a hint that simultaneously the high-frequency slope becomes steeper. Finally, the X-ray time-lag spectrum of NGC 7314 shows some very weak signatures of relativistic reflection, and the energy resolved time-lag spectrum, for frequencies around 3 × 10-4 Hz, shows no signatures of X-ray reverberation. We show that the previous claim about ks time delays in this source, is simply an artefact induced by the minuscule number of points entering during the time-lag estimation in the low-frequency part of the time-lag spectrum (i.e. below 10-4 Hz).

  6. Comparative study of human mitochondrial proteome reveals extensive protein subcellular relocalization after gene duplications

    Directory of Open Access Journals (Sweden)

    Huang Yong

    2009-11-01

    Full Text Available Abstract Background Gene and genome duplication is the principle creative force in evolution. Recently, protein subcellular relocalization, or neolocalization was proposed as one of the mechanisms responsible for the retention of duplicated genes. This hypothesis received support from the analysis of yeast genomes, but has not been tested thoroughly on animal genomes. In order to evaluate the importance of subcellular relocalizations for retention of duplicated genes in animal genomes, we systematically analyzed nuclear encoded mitochondrial proteins in the human genome by reconstructing phylogenies of mitochondrial multigene families. Results The 456 human mitochondrial proteins selected for this study were clustered into 305 gene families including 92 multigene families. Among the multigene families, 59 (64% consisted of both mitochondrial and cytosolic (non-mitochondrial proteins (mt-cy families while the remaining 33 (36% were composed of mitochondrial proteins (mt-mt families. Phylogenetic analyses of mt-cy families revealed three different scenarios of their neolocalization following gene duplication: 1 relocalization from mitochondria to cytosol, 2 from cytosol to mitochondria and 3 multiple subcellular relocalizations. The neolocalizations were most commonly enabled by the gain or loss of N-terminal mitochondrial targeting signals. The majority of detected subcellular relocalization events occurred early in animal evolution, preceding the evolution of tetrapods. Mt-mt protein families showed a somewhat different pattern, where gene duplication occurred more evenly in time. However, for both types of protein families, most duplication events appear to roughly coincide with two rounds of genome duplications early in vertebrate evolution. Finally, we evaluated the effects of inaccurate and incomplete annotation of mitochondrial proteins and found that our conclusion of the importance of subcellular relocalization after gene duplication on

  7. Dietary chocolate colors during their storage up to 1 year

    Directory of Open Access Journals (Sweden)

    Popov-Raljić Jovanka

    2007-01-01

    Full Text Available In this work color quality characteristics of the upper surfaces of commercial dietary chocolates of different manufacturers were investigated. Color was determined instrumentally, using the three stimulus colorimeter "MINOLTA" Chroma meter CR 400. Results were expressed in CIE, CIELab and Hünter systems, immediately after the production (0 - 30 days and after 90, 180, 270 and 360 days of keeping in storage at the temperature of 15°C. Whitening Index (WI was also calculated. On the basis of the obtained results, it could be concluded that all the analyzed samples of dietary chocolates had approximately the same color characteristics qualities (lightness, nuance and color saturation, having only negligible variations, during keeping and storage at 15°C for up to 1 year.

  8. Relationship between tongue strength and 1-year life expectancy in elderly people needing nursing care.

    Science.gov (United States)

    Yajima, Yuri; Kikutani, Takeshi; Tamura, Fumiyo; Yoshida, Mitsuyoshi

    2017-01-05

    Tongue strength is a useful indicator of oral function and has been found to decrease with aging and reduced physical functioning. The present study aimed to assess the relationships of tongue strength with physical function, mental function, and nutritional status, and also between these factors and 1-year outcomes, to determine whether tongue strength is related to life expectancy in elderly people needing nursing care. The subjects were 140 elderly individuals requiring needing nursing care (49 men and 91 women; ≥65 years). The investigated items included sex, age, activities of daily living (ADL), comorbidity, cognitive function, nutritional status, eating function, occlusal support, and tongue strength. Furthermore, a follow-up study was conducted 1 year later, and factors related to death were identified. The mean tongue strength of the total 140 subjects was 20.3 ± 8.6 kPa. Tongue strength was assessed relative to each of the investigated items, using the t test and one-way analysis of variance. Tongue strength was significantly related to ADL, comorbidity, cognitive function, calf circumference, food intake, and occlusal support. Fifteen subjects were found to have died at the 1-year follow-up study. We assessed the relationships of 1-year outcomes with each of the factors examined, and 1-year outcomes were found to be significantly related to ADL and tongue strength.

  9. Algebraic extensions of fields

    CERN Document Server

    McCarthy, Paul J

    1991-01-01

    ""...clear, unsophisticated and direct..."" - MathThis textbook is intended to prepare graduate students for the further study of fields, especially algebraic number theory and class field theory. It presumes some familiarity with topology and a solid background in abstract algebra. Chapter 1 contains the basic results concerning algebraic extensions. In addition to separable and inseparable extensions and normal extensions, there are sections on finite fields, algebraically closed fields, primitive elements, and norms and traces. Chapter 2 is devoted to Galois theory. Besides the fundamenta

  10. Flexion-extension gap in cruciate-retaining versus posterior-stabilized total knee arthroplasty: a cadaveric study.

    Science.gov (United States)

    Matthews, Joshua; Chong, Alexander; McQueen, David; O'Guinn, Justin; Wooley, Paul

    2014-05-01

    We re-examined experimental model results using half-body specimens with intact extensor mechanisms and navigation to evaluate cruciate-retaining (CR) and posterior stabilized (PS) total knee arthroplasty (TKA) component gaps through an entire range of motion. Six sequential testing regimens were conducted with the knee intact, with a CR TKA in place, and with a PS TKA in place, with and without 22 N traction in place at each stage. Each of 10 knees was taken through six full ranges of motion from 0° to 120° at every stage using a navigated knee system to record component gapping. No significant difference was found between loaded and unloaded component gaps, and no significant differences were found in component gapping between CR and PS TKAs throughout a full range of motion. Flexion-extension gap measurements were significantly different from previously published data (at 90° flexion). No difference was found in kinematics when comparing CR and PS TKA component designs. Our results suggest that intact extensor mechanisms may be required to perform proper kinematic studies of TKA. Our findings provide evidence that the extensor mechanism may play a major role in the flexion-extension gaps in cadaveric knees.

  11. Hydrological performance of an extensive green roof: a case study from the central Europe (Bustehrad, Czech Republic)

    Science.gov (United States)

    Tománková, Klára; Sněhota, Michal; Jelínková, Vladimíra

    2016-04-01

    Extensive green roofs with a thin growing medium require minimal maintenance, and in general no irrigation. The proper functioning of such systems rests with their structural constituents, especially with the substrate used for planting. An extensive green roof with poorly developed vegetation and with a soil layer of a maximum thickness of 5 cm mixed with local stripped topsoil with crushed bricks and green waste was studied with respect to the hydrological behavior. The substrate classified as loam comprises a significant proportion of very fine particles and thus it is prone to clogging up of soil pores and forming of fissures on the surface. The green roof studied is well equipped for measuring meteorological data including air temperature, wind speed and direction, net radiation, relative humidity, and rainfall intensity. The meteorological information on the site is completed by soil temperature measurement. The 12 m long transect is equipped with eight time domain reflectometry probes (TDR) to monitor soil water content. Soil physical properties (bulk density, porosity, grain size distribution) and soil hydraulic characteristics (soil water retention curve) were obtained. The numerical modeling of transient soil water movement in the green roof substrate was performed using a two-dimensional model based on the Richards' equation. Results were compared with the soil water content data acquired. Six alternative scenarios were formulated to discuss possible improvement of green roof functioning and four selected scenarios were simulated. The study helped us to improve our understanding of the flow processes through the green roof soil system under study. The alternative scenario simulations allowed hydrological assessment of roof construction amendments. The research was realized as a part of the University Centre for Energy Efficient Buildings supported by the EU and with financial support from the Czech Science Foundation under project number 14-10455P.

  12. Spiritual absence and 1-year mortality after hematopoietic stem cell transplant.

    Science.gov (United States)

    Pereira, Deidre B; Christian, Lisa M; Patidar, Seema; Bishop, Michelle M; Dodd, Stacy M; Athanason, Rebecca; Wingard, John R; Reddy, Vijay S

    2010-08-01

    Religiosity and spirituality have been associated with better survival in large epidemiologic studies. This study examined the relationship between spiritual absence and 1-year all-cause mortality in allogeneic hematopoietic stem cell transplant (HSCT) recipients. Depression and problematic compliance were examined as possible mediators of a significant spiritual absence-mortality relationship. Eighty-five adults (mean = 46.85 years old, SD = 11.90 years) undergoing evaluation for allogeneic HSCT had routine psychologie evaluation prior to HSCT admission. The Millon Behavioral Medicine Diagnostic was used to assess spiritual absence, depression, and problematic compliance, the psychosocial predictors of interest. Patient status at 1 year and survival time in days were abstracted from medical records. Cox regression analysis was used to examine the relationship between the psychosocial factors of interest and mortality after adjusting for relevant biobehavioral factors. Twenty-nine percent (n = 25) of participants died within 1 year of HSCT. After covarying for disease type, individuals with the highest spiritual absence and problematic compliance scores were significantly more likely to die 1-year post-HSCT (hazard ratio [HR] = 2.49, P = .043 and HR = 3.74, P = .029, respectively), particularly secondary to infection, sepsis, or graft-versus-host disease (GVHD) (HR = 4.56, P = .01 and HR = 5.61, P = .014), relative to those without elevations on these scales. Depression was not associated with 1-year mortality, and problematic compliance did not mediate the relationship between spiritual absence and mortality. These preliminary results suggest that both spiritual absence and problematic compliance may be associated with poorer survival following HSCT. Future research should examine these relations in a larger sample using a more comprehensive assessment of spirituality.

  13. Outcome of knee injuries in general practice: 1-year follow-up

    OpenAIRE

    2010-01-01

    Background Knee injuries may lead to pain and to functional limitations in the activities of daily living. Patients with knee injuries are frequently seen in general practice; however, the outcome and management in these patients is not known. Aim To assess the outcome and management of knee injuries at 12 months' follow-up in general practice. Design of study A prospective observational cohort study with a 1-year follow-up. Setting. Primary health care. Method Adult patients consulting their...

  14. Application of capillary electrophoresis to the simultaneous determination and stability study of four extensively used penicillin derivatives

    Directory of Open Access Journals (Sweden)

    Brigitta Simon

    2014-09-01

    Full Text Available The applicability of capillary electrophoresis for the analysis of four extensively used penicillin derivatives (benzylpenicillin, ampicillin, amoxicillin, oxacilllin has been studied. Because of structural similarities, the electrophoretic behavior of these derivatives is very similar; consequently an efficient separation using the conventional capillary zone electrophoresis is hard to be achieved. Their simultaneous separation was solved by using micellar electrokinetic capillary chromatography, the separation being based on the differential partition of the analytes between the micellar and aqueous phase. Using a buffer solution containing 25 mM sodium tetraborate and 100 mM sodium dodecyl sulfate as surfactant, at a pH of 9.3, applying a voltage of + 25 kV at a temperature of 25 °C, we achieved the simultaneous separation of the studied penicillin derivatives in less then 5 minutes. The separation conditions were optimized and the analytical performance of the method was evaluated in terms of precision, linearity, limit of detection, and quantification. Also, a simple capillary zone electrophoresis method was applied to study the stability of the studied penicillin derivatives in water at different temperatures, using ciprofloxacin hydrochloride as internal standard. It was observed that the extent of the hydrolysis of penicillins in water is highly dependent on the time and also temperature.

  15. AOAC Official MethodSM Matrix Extension Validation Study of Assurance GDSTM for the Detection of Salmonella in Selected Spices.

    Science.gov (United States)

    Feldsine, Philip; Kaur, Mandeep; Shah, Khyati; Immerman, Amy; Jucker, Markus; Lienau, Andrew

    2015-01-01

    Assurance GDSTM for Salmonella Tq has been validated according to the AOAC INTERNATIONAL Methods Committee Guidelines for Validation of Microbiological Methods for Food and Environmental Surfaces for the detection of selected foods and environmental surfaces (Official Method of AnalysisSM 2009.03, Performance Tested MethodSM No. 050602). The method also completed AFNOR validation (following the ISO 16140 standard) compared to the reference method EN ISO 6579. For AFNOR, GDS was given a scope covering all human food, animal feed stuff, and environmental surfaces (Certificate No. TRA02/12-01/09). Results showed that Assurance GDS for Salmonella (GDS) has high sensitivity and is equivalent to the reference culture methods for the detection of motile and non-motile Salmonella. As part of the aforementioned validations, inclusivity and exclusivity studies, stability, and ruggedness studies were also conducted. Assurance GDS has 100% inclusivity and exclusivity among the 100 Salmonella serovars and 35 non-Salmonella organisms analyzed. To add to the scope of the Assurance GDS for Salmonella method, a matrix extension study was conducted, following the AOAC guidelines, to validate the application of the method for selected spices, specifically curry powder, cumin powder, and chili powder, for the detection of Salmonella.

  16. [Postoperative morbidity in surgically treated extension fractures of the distal radius. A comparative study of dorsal and volar approach].

    Science.gov (United States)

    Zettl, R P; Ruchholtz, S; Taeger, G; Obertacke, U; Nast-Kolb, D

    2001-08-01

    The aim of this study was to investigate perioperative morbidity in operative interventions in distal radiusfractures, comparing the operative approach from volar and dorsal. Only problems, resulting from the operative approach towards the distal aspect of the radius, were examined. In a Case-Control-Study, we investigated patients with operative by plate-osteosynthesis treated distal radius-extensions-fractures. During 3 years we investigated 92 patients. 49 were operated with a volar approach, and after changing the operative management, consecutive 43 patients with a dorsal approach to the distal radius. Indications for operative treatment were not changed. The approach to the distal aspect of the radius corresponded to the recent guidelines. Further perioperative procedures were identical, including procedures in anesthesiology. Datas of patients have been investigated for epidemiology, kind of operations, point of time in treatment, duration of operation, X-Ray, immobilisation and time of inhospital stay as well as all documented complications. It has been shown, that in respect of all criterias, concerning length of operation (106 vs. 83 min), intraoperative X-Ray (3.0 vs. 1.65 min) as well as postoperative immobilisation (33 vs. 25 days), and documented incidences of complications like secondary wound-healing (19/49 vs. 0/43) or nerval irritations (13/49 vs. 1/43), the dorsal osteosynthesis is definitively to be favored.

  17. The Type IIP SN 2005ay: An Extensive Study From UltraViolet To Near-IR

    Science.gov (United States)

    Bufano, F. M.; Turatto, M.; Zampieri, L.; Gal-Yam, A.

    2006-08-01

    Several supernova types are thought to explode via the gravitational collapse of the core of massive stars at the end of their lifetimes. The great observational diversity has not been fully understood even if it clearly involves the progenitor masses and configurations at the time of explosion. These Supernovae, called Core Collapse Supernovae (CC SNe), are expected to dominate the counts of SNe observed at high redshifts and to be the only observable probe of the first generation stars (Pop III). Recently indicated as reliable distance indicators (Hamuy 02, Pastorello `03), CC SNe are objects of great interest but significantly less studied in comparison with the Termonuclear ones. With the aim to understand better the reasons of the heterogeneous behaviour , we have started an extensive study of the properties of SN II with different observational features (luminosity, velocity, etc..). Here we present the last results on our first observed target, SN2005ay, a Type IIP supernova observed in an extended way from the Ultraviolet wavelengths, provided by the GALEX , to the Optical and near-IR , obtained with IISP (Italian Intensive Supernova Program).

  18. Lagrangian study of surface transport in the Kuroshio Extension area based on simulation of propagation of Fukushima-derived radionuclides

    CERN Document Server

    Prants, S V; Uleysky, M Yu

    2013-01-01

    Lagrangian approach is applied to study near-surface large-scale transport in the Kuroshio Extension area using a simulation with synthetic particles advected by AVISO altimetric velocity field. A material line technique is applied to find the origin of water masses in cold-core cyclonic rings pinched off from the jet in summer 2011. Tracking and Lagrangian maps provide the evidence of cross-jet transport. Fukushima derived caesium isotopes are used as Lagrangian tracers to study transport and mixing in the area a few months after the March of 2011 tsunami that caused a heavy damage of the Fukushima nuclear power plant (FNPP). Tracking maps are computed to trace the origin of water parcels with measured levels of Cs-134 and Cs-137 concentrations collected in two R/V cruises in June and July 2011 in the large area of the Northwest Pacific. It is shown that Lagrangian simulation is useful to finding the surface areas that are potentially dangerous due to the risk of radioactive contamination. The results of sim...

  19. Effectiveness of Agricultural Extension Activities

    Directory of Open Access Journals (Sweden)

    Ali AL-Sharafat

    2012-01-01

    Full Text Available Problem statement: Jordans agricultural extension service is seriously under-staffed and its effectiveness is consequently compromised. Reservations are being expressed about the performance and capability of the agricultural extension system in Jordan. The performance of this sector has been disappointing and has failed to transfer agricultural technology to the farmers. The main objective of this study is to assess the effectiveness of Jordans agricultural extension services. Approach: The effect of extension services on olive productivity in the study area was investigated. A total number of 60 olive producers were selected to be interviewed for this study. This number was enough to achieve the study objectives. The interviewed producers were distributed almost equally within olive production locations in the study area. The sample obtained through the simple random sampling technique. The two groups had been chosen and distributed randomly into an experimental group (30 farmers; 10 for each source of extension service and control group (30 farmers. The experimental group received extension services and the control group received no extension services. Two interview-cum-structured questionnaires were designed and used to collect information and data for this study. The first instrument was designed for farmers who received extension services and the second from farmers who received no extension services. Another questionnaire was designed for administrators of extension organizations concerned with providing extension services to farmers. To find the differences that may exist between two studied groups, One Way Analysis of Variance (ANOVA, t-test and LSD test via Statistical Package for Social Sciences software (SPSS were used. The average net profit obtained from an area of one dynamo of olive farm was the main item to be considered in determining the effectiveness of agricultural extension activities. Results and Conclusion: The results of

  20. Long-term safety and efficacy of clobazam for Lennox-Gastaut syndrome: interim results of an open-label extension study.

    Science.gov (United States)

    Ng, Yu-Tze; Conry, Joan; Paolicchi, Juliann; Kernitsky, Lydia; Mitchell, Wendy; Drummond, Rebecca; Isojarvi, Jouko; Lee, Deborah; Owen, Randall

    2012-12-01

    In an ongoing open-label extension (OV-1004), patients with Lennox-Gastaut syndrome who had completed 1 of 2 randomized controlled trials (OV-1002 [Phase II] or OV-1012 [Phase III]) are receiving clobazam at dosages ≤2.0 mg/kg/day (≤80 mg/day). Of 306 eligible patients from OV-1002 or OV-1012, 267 entered the open-label extension. As of the interim date, July 1, 2010, 213 patients (79.8%) had remained in the trial, and 189 had received clobazam for ≥12 months, 128 for ≥18 months, and 94 for ≥24 months. Median percentage decreases in average weekly rates of drop seizures were 71.1% and 91.6% at Months 3 and 24. Mean modal and mean maximum daily dosages were 0.94 mg/kg and 1.22 mg/kg for those who had received clobazam for ≥1 year. The 4 most common adverse events were upper respiratory tract infection (18.4%), fall (14.2%), pneumonia (13.9%), and somnolence (12.7%). Clobazam's adverse event profile was consistent with its profile in controlled trials.

  1. Effects on Metabolic Health after a 1-Year-Lifestyle Intervention in Overweight and Obese Children: A Randomized Controlled Trial

    Directory of Open Access Journals (Sweden)

    Maria Waling

    2012-01-01

    Results. BMI z-scores decreased in both groups, 0.22 (P = 0.002 and 0.23 (P = 0.003 in intervention and control group, respectively, during the 1-year study, but there was no difference in BMI between the groups at 1-year measurement (P = 0.338. After 1 year, there was a significant difference in waist circumference, waist/hip ratio, and apolipoprotein B/A1 ratio between intervention and control group. Conclusions. The intervention had limited effects on anthropometrics and metabolic markers, which emphasizes the need of preventing childhood overweight and obesity.

  2. Sniff to see. Comparing sniffing position versus simple head extension position for glottic exposure - A prospective, randomized cross over study

    Directory of Open Access Journals (Sweden)

    Nishant Sahay

    2016-01-01

    Conclusion: Sniffing position provides better glottis exposure and it is easier to intubate a patient in the sniffing position as compared to simple head extension position. Sniffing position should therefore be used as initial position when attempting intubation.

  3. RAPID KNEE-EXTENSIONS TO INCREASE QUADRICEPS MUSCLE ACTIVITY IN PATIENTS WITH TOTAL KNEE ARTHROPLASTY: A RANDOMIZED CROSS-OVER STUDY

    Science.gov (United States)

    Wilquin, Lousia; Jakobsen, Thomas Linding; Holsgaard-Larsen, Anders; Bandholm, Thomas

    2017-01-01

    Background Inhibition of the quadriceps muscle and reduced knee-extension strength is common shortly following total knee arthroplasty (weeks to months), due to reduced voluntary activation of the quadriceps muscle. In healthy subjects, strength training with heavy loads is known to increase agonist muscle activity, especially if the exercise is conducted using rapid muscle contractions. Purpose The purpose of this study was to examine if patients with total knee arthroplasty could perform rapid knee-extensions using a 10 RM load four to eight weeks after surgery, and the degree to which rapid knee-extensions were associated with greater voluntary quadriceps muscle activity during an experimental strength training session, compared to that elicited using slow knee-extensions. Study Design A randomized cross-over study. Methods Twenty-four patients (age 66.5) 4-8 weeks post total knee arthroplasty randomly performed one set of five rapid, and one set of five slow knee-extensions with the operated leg, using a load of their 10 repetition maximum, while surface electromyography recordings were obtained from the vastus medialis and lateralis of the quadriceps muscle. Results Data from 23 of the 24 included patients were analyzed. Muscle activity was significantly higher during rapid knee-extensions (120.2% [10th-90th percentile: 98.3-149.1]) compared to slow knee-extensions (106.0% [88.8-140.8]) for the vastus lateralis (pknee-extensions were performed at a median angular velocity of 19.7 degrees/sec (13.7-24.4) and 51.4 degrees/sec (28.9-63.1), respectively Conclusion Four to eight weeks after their total knee arthroplasty, the patients in the present study were able to conduct rapid knee-extensions according to the experimental protocol with an approximately doubled angular velocity compared to slow knee-extensions. This was associated with increased muscle activity in the vastus lateralis when compared to slow knee-extensions, but not in the vastus medialis. Whether

  4. Validation of Health Extension Workers Job Motivation Scale in Gamo-Gofa Zone, Southern Ethiopia: A Cross-Sectional Study.

    Science.gov (United States)

    Mohammed, Shikur; Tilahun, Marelign; Kote, Mesfin; Mama, Mohamedaman; Tamiru, Dessalegn

    2015-01-01

    Introduction. Well-trained and highly motivated community health workers are critical for delivery of community-based health care services. Understanding what motivates especially community health care providers for better community health requires the use of psychometrically reliable and valid scale. This study was conducted to validate job motivation scale in Gamo Gofa Zone, Southern Ethiopia. Methods. A cross-sectional study was conducted in 150 health care posts in Gamo Gofa Zone, from February 01, 2013, to March 01, 2013. A total of 301 participants responded to questionnaires asking about sociodemographic characteristics and job motivation. Exploratory factor analysis with principal component extraction and varimax with Kaiser Normalization rotation were employed to develop scales for job motivation. Eigenvalues greater than 1 were used as criterion of extraction. Items with item factor loadings less than 0.4 and double loaded items were dropped. Alpha and exploratory factor analyses were examined to test reliability and validity of the scale. Results. During exploratory factor analysis eight factors emerged from the three dimensions of job motivation scale, namely, educational career, workload, financial incentive, supervisor encouragement, community recognition, access to infrastructure, living condition, and better achievement in work. The factor loadings of the items in each dimension ranged from 0.58 to 0.83. Crobach's alpha of the scales ranged from 0.79 to 0.90. To check validities of the scales developed in this study, the previous studies conducted to develop job motivation scale were used. Conclusion. Although the present scale has the potential to measure the job motivation of health extension workers and it is low in cost and easy to administer and analyze, it should be field-tested at different settings.

  5. A study on the extension of the cycle length and change of the fuel reloading pattern for HANARO

    Energy Technology Data Exchange (ETDEWEB)

    Lee, C. S.; Jeo, D. G.; Park, S. J.; Kim, H. I. [KAERI, Taejon (Korea, Republic of)

    2003-10-01

    HANARO is operated with the cycle length of 28 days at 30MW and thus about 9 cycles a year. Three 36-element assemblies and two 18-element assemblies are discharged in the core and refueled. About 27 36-element assemblies and 18 18-element assemblies are consumed during a year. To reduce the consumption of fuel assemblies, the methods extending the cycle length and changing the fuel reloading pattern were studied in this paper. These two methods make the maximum linear power higher than current value. The excess reactivity at the end of cycle for the cycle length of 29.5 and 30 days is reduced to 14.4 mk and 11.0 mk. By the extension of the cycle length, more than two 36-element fuel assemblies are saved during a year. When the fuel reloading pattern is changed, the excess reactivity at the end of cycle has the value from 14 mk to 23 mk and two 18-element assemblies are saved during a year. But it is needed to manage the irradiation tests in the core because of decreasing the excess reactivity.

  6. Extensive study of HD 25558, a long-period double-lined binary with two SPB components

    CERN Document Server

    Sódor, Á; Wright, D J; Neiner, C; Briquet, M; Lampens, P; Dukes, R J; Henry, G W; Williamson, M H; Brunsden, E; Pollard, K R; Cottrell, P L; Maisonneuve, F; Kilmartin, P M; Matthews, J; Kallinger, T; Beck, P G; Kambe, E; Engelbrecht, C A; Czanik, R J; Yang, S; Hashimoto, O; Honda, S; Fu, J N; Castanheira, B; Lehmann, H; Bognár, Zs; Behara, N; Scaringi, S; Van Winckel, H; Menu, J; Lobel, A; Mathias, P; Saesen, S; Vučković, M

    2013-01-01

    We carried out an extensive observational study of the Slowly Pulsating B (SPB) star, HD 25558. The ~2000 spectra obtained at different observatories, the ground-based and MOST satellite light curves revealed that this object is a double-lined spectroscopic binary with an orbital period of about 9 years. The observations do not allow the inference of an orbital solution. We determined the physical parameters of the components, and found that both lie within the SPB instability strip. Accordingly, both show line-profile variations due to stellar pulsations. Eleven independent frequencies were identified in the data. All the frequencies were attributed to one of the two components based on Pixel-by-pixel variability analysis of the line profiles. Spectroscopic and photometric mode identification was also performed for the frequencies of both stars. These results suggest that the inclination and rotation of the two components are rather different. The primary is a slow rotator with ~6 d period, seen at ~60 deg i...

  7. A pilot study for the analysis of dream reports using Maslow's need categories: an extension to the emotional selection hypothesis.

    Science.gov (United States)

    Coutts, Richard

    2010-10-01

    The emotional selection hypothesis describes a cyclical process that uses dreams to modify and test select mental schemas. An extension is proposed that further characterizes these schemas as facilitators of human need satisfaction. A pilot study was conducted in which this hypothesis was tested by assigning 100 dream reports (10 randomly selected from 10 dream logs at an online web site) to one or more categories within Maslow's hierarchy of needs. A "match" was declared when at least two of three judges agreed both for category and for whether the identified need was satisfied or thwarted in the dream narrative. The interjudge reliability of the judged needs was good (92% of the reports contained at least one match). The number of needs judged as thwarted did not differ significantly from the number judged as satisfied (48 vs. 52%, respectively). The six "higher" needs (belongingness, esteem, cognitive, aesthetic, self-actualization, and transcendence) were scored significantly more frequently (81%) than were the two lowest or "basic" needs (physiological and safety, 19%). Basic needs were also more likely to be judged as thwarted, while higher needs were more likely to be judged as satisfied. These findings are discussed in the context of Maslow's hierarchy of needs as a framework for investigating theories of dream function, including the emotional selection hypothesis and other contemporary dream theories.

  8. Primer extension studies on alpha-amylase mRNAs in barley aleurone. II. Hormonal regulation of expression.

    Science.gov (United States)

    Chandler, P M; Jacobsen, J V

    1991-04-01

    Relative levels of different alpha-amylase mRNAs were assessed by primer extension experiments using RNA prepared from aleurone of barley (Hordeum vulgare L. cv. Himalaya). Three different aleurone systems were studied: protoplasts prepared from aleurone layers, isolated aleurone layers, and aleurone from germinated grain. Oligonucleotide primers specific for the low-pI and high-pI alpha-amylase groups allowed the levels of different alpha-amylase mRNAs to be assessed both within and between the two groups. In all aleurone systems the same set of alpha-amylase mRNAs was produced in response to either applied gibberellic acid (aleurone protoplasts, isolated aleurone layers) or, presumably, native gibberellin(s) (germinated grain). This result indicates that the same set of genes is being expressed in each case. Differences were observed between the different aleurone systems in regulation of levels of alpha-amylase mRNAs. In particular, the regulation of alpha-amylase mRNA levels in aleurone of germinated grain has unique features which are not adequately explained by the response of isolated aleurone layers to gibberellic acid.

  9. Three-dimensional assessment of mandibular advancement 1 year after surgery

    Science.gov (United States)

    de Assis Ribeiro Carvalho, Felipe; Cevidanes, Lucia Helena Soares; Motta, Alexandre Trindade Simões da; de Oliveira Almeida, Marco Antonio; Phillips, Ceib

    2010-01-01

    Introduction This prospective observational study evaluated changes in the 3-dimensional position and remodeling of the mandibular rami, condyles, and chin at splint removal and 1 year after mandibular advancement surgery. Methods Presurgery, splint removal (4–6 weeks postsurgery), and 1-year postsurgery cone-beam computed tomography scans of 27 subjects were used. Superimposition on the cranial base was used to assess positional or remodeling changes in the anatomic regions of interest. Surface distance displacements were visually displayed and quantified by 3-dimensional color maps. A 1-sample t test was used to assess the average postsurgical changes of each region of interest. The level of significance was set at 0.05. Results After antero-inferior chin displacement with surgery (mean, 6.81 ± 3.2 mm at splint removal), the average 1-year post-surgery displacement was not statistically significant (P = 0.44). Postsurgical adaptations greater than 2 mm were observed in 48% of the patients: 16% with an additional anterior-inferior displacement of the chin of 2 to 4 mm, and 4% with ≥4 mm; 20% had postero-superior movement of 2 to 4 mm, and 8% had postero-superior movement of ≥4 mm. The condyles tended to move, on average, ≤2 mm supero-posteriorly with surgery, and this small positional displacement was maintained 1 year postsurgery (right condyle, P = 0.58; left, P = 0.88). The rami exhibited outward (lateral) movements with surgery, with greater displacement of the inferior part of the rami (≥2 mm in 65% of the subjects). This torque of the ramus with surgery was stable 1 year postsurgery. Conclusions Three-dimensional assessment of skeletal changes with mandibular advancement surgery shows that nearly half of the patients have >2 mm change in chin position from splint removal to the 1-year follow-up, with approximately equal chances of anterior and posterior movement. Torque of the rami usually occurs with mandibular advancement surgery. PMID:20381760

  10. Phase 1 and Extension Study of Clofarabine plus Cyclophosphamide in Patients with Relapsed/Refractory Acute Lymphoblastic Leukemia (ALL)

    Science.gov (United States)

    Faderl, S; Balakrishnan, K; Thomas, DA; Ravandi, F; Borthakur, G; Burger, J; Ferrajoli, A; Cortes, J; O’Brien, S; Kadia, T; Feliu, J; Plunkett, W; Gandhi, V; Kantarjian, HM

    2014-01-01

    Background Clofarabine is a nucleoside analog with activity in children with ALL. Based on the hypothesis that clofarabine inhibits DNA repair following exposure to DNA damaging agents, we designed a phase 1 and extension study to evaluate the combination of clofarabine with cyclophosphamide in adult patients with relapsed/refractory ALL. Methods The continual reassessment method (CRM) was used to define the maximum tolerated dose (MTD). Results Fifty patients with a median age of 30 years (range 21–72 years) were enrolled of whom 30 patients were part of the phase 1 group. Clofarabine 40 mg/m2 iv daily x 3 days and cyclophosphamide 200 mg/m2 iv q 12 hours x 3 days were established as the MTD. Dose limiting toxicities were diarrhea, transaminase elevations, and skin rashes. The response rate of the whole study group was 14% including 10% of patients who achieved complete remission (CR) or CR without platelet recovery. Three responses occurred in patients with primary refractory disease. Early mortality (< 30 days) was 6%. The median response duration was 69 days (range 5–315 days). Median overall survival was about 3 months. Compared to day 1 (cyclophosphamide alone), H2AX phosphorylation was increased on day 2 when clofarabine and cyclophosphamide were administered as a couplet (n = 8). Conclusions The combination of clofarabine plus cyclophosphamide at the doses used in this study and in a group of heavily pretreated patients with ALL is only moderately effective. Other doses, alternative schedules, or a more favorable patient population may achieve better results. (Word count: 248) PMID:24440659

  11. Study on New Extension Pattern Classifiers%新的可拓模式分类器研究

    Institute of Scientific and Technical Information of China (English)

    管凤旭; 王科俊; 姜倩

    2013-01-01

    为了解决传统可拓模式分类器只适合用于模式类别较少和一维数据等缺点,针对可拓学中可拓距和关联函数的特点,提出了采用可拓距和关联函数新的可拓模式分类器,包括平均关联函数法、K最大关联函数法和最大关联函数法.详细介绍三种可拓模式分类器的设计步骤;并针对平均样本法、平均距离法、K近邻法、最近邻法和三种可拓模式分类器,采用二维平面数据、多维向量数据和手指静脉图像特征矩阵数据进行实验对比分析.实验结果表明:新的基于可拓距与关联函数的可拓模式分类器算法不仅可以解决模式类别较多的多维数据问题,分类效果也可以达到经典的K近邻分类器或最近邻分类器的分类水平.%In order to overcome some defects that the traditional extension pattern classifier is only suitable for little small pattern classification and one -dimensional data, according to the characteristics of the extension distance and the correlation function of extension, three new algorithms of extension pattern classifier were proposed. The algorithms are the average correlation function, K - maximum correlation function and maximum correlation function based on the extension distance and the extension correlation function. The steps of the extension pattern classifiers were introduced in detail. For these classifiers of the average sample, the average distance, the k - nearest neighbor, the nearest neighbor and the extension pattern classifiers, the two - dimensional data, the multi - dimensional vector data and the matrix data of finger vein image feature were used to compare and analyze the classification effects of the extension pattern classifiers. Experimental results show that the new extension pattern classifiers can deal with multiple patterns and multi - dimensional data, and its classification result can reach the level of k - nearest neighbor classifier or nearest neighbor

  12. Improved MR imaging of the cervical spine, 2; Study of disk protrusion in the cervical spine in flexion-versus-extension views

    Energy Technology Data Exchange (ETDEWEB)

    Tanno, Munehiko; Kyomasu, Yoshinori; Nakayama, Masafumi (Tokyo Metropolitan Geriatric Hospital, Tokyo (Japan)) (and others)

    1990-12-01

    Comparative study of incidence of disk protrusion was performed on the basis of MR imaging in a state of flexion versus extension. The results showed that the incidnece of disk protrusion at each disk level was generally higher on the extension images than on the flexion images at the corresponding levels. The degree of difference in the incidence of the disk protrusion on flexion and extension was the greatest at the mid-cervical level spine. Based on the results with respect to features of the cervical spine in extension and flexion, it appears that the difference in incidence of disk protrusion is probably caused by movement in response to bending of the cervical spine. These results may provide information concerning the dynamic of cervical disks and may partly explain cases in which patients have symptoms of cervical myelopathy and/or radiculopathy but have no disk protrusion on images in the neutral position. (author).

  13. Longitudinal study of a heteroplasmic 3460 Leber hereditary optic neuropathy family by multiplexed primer-extension analysis and nucleotide sequencing

    Energy Technology Data Exchange (ETDEWEB)

    Ghosh, S.S.; Fahy, E. [Applied Genetics, San Diego, CA (United States); Bodis-Wollner, I. [State Univ. of New York College of Optometry, New York, NY (United States)] [and others

    1996-02-01

    Nucleotide-sequencing and multiplexed primer-extension assays have been used to quantitate the mutant-allele frequency in 14 maternal relatives, spanning three generations, from a family that is heteroplasmic for the primary Leber hereditary optic neuropathy (LHON) mutation at nucleotide 3460 of the mitochondrial genome. There was excellent agreement between the values that were obtained with the two different methods. The longitudinal study shows that the mutant-allele frequency was constant within individual family members over a sampling period of 3.5 years. Second, although there was an overall increase in the mutant-allele frequency in successive generations, segregation in the direction of the mutant allele was not invariant, and there was one instance in which there was a significant decrease in the frequency from parent to offspring. From these two sets of results, and from previous studies of heteroplasmic LHON families, we conclude that there is no evidence for a marked selective pressure that determines the replication, segregation, or transmission of primary LHON mutations to white blood cells and platelets. Instead, the mtDNA molecules are most likely to replicate and segregate under conditions of random drift at the cellular level. Finally, the pattern of transmission in this maternal lineage is compatible with a developmental bottleneck model in which the number of mitochondrial units of segregation in the female germ line is relatively small in relation to the number of mtDNA molecules within a cell. However, this is not an invariant pattern for humans, and simple models of mitochondrial gene transmission are inappropriate at the present time. 37 refs., 4 figs., 1 tab.

  14. Matrix Extension Study: Validation of the Compact Dry TC Method for Enumeration of Total Aerobic Bacteria in Selected Foods.

    Science.gov (United States)

    Mizuochi, Shingo; Nelson, Maria; Baylis, Chris; Jewell, Keith; Green, Becky; Limbum, Rob; Fernandez, Maria Cristina; Salfinger, Yvonne; Chen, Yi

    2016-01-01

    A validation study was conducted to extend the matrix claim for the Nissui Compact Dry Total Count (TC), Performance Tested Method(s)(SM) (PTM) Certification No. 010404, to cooked chicken, lettuce, frozen fish, milk powder, and pasteurized whole milk. The method was originally certified by the AOAC Research Institute Performance Tested Method(s)(SM) Program for raw meat products. The Compact Dry TC is a ready-to-use dry media sheet that is rehydrated by adding 1 mL of diluted sample. A total aerobic colony count can be determined in the sample following 48 h of incubation. Matrix extension studies were conducted by Campden BRI (formerly Campden and Chorleywood Food Research Association Technology Limited), Chipping Campden, UK. Single-laboratory data were collected for cooked chicken, lettuce, frozen fish, and milk powder, whereas a multilaboratory study was conducted on pasteurized milk. Fourteen laboratories participated in the collaborative study. The Compact Dry TC was tested at two time points, 48 ± 3 h and 72 ± 3 h and compared with the current International Organization for Standardization (ISO) method at the time of the study, ISO 4833:2003 (this standard is withdrawn and has been replaced by: ISO 4833-1:2013 and ISO 4833-2:2013), Microbiology of food and animal feeding stuffs-Horizontal method for the enumeration of microorganisms-Colony-count technique at 30°C. The data were logarithmically transformed and evaluated for repeatability (plus reproducibility for pasteurized milk), RSD of repeatability (plus RSD of reproducibility for milk), r(2), and mean difference between methods with 95% confidence interval (CI). A CI outside of (-0.5 to 0.5) on the log10 mean difference was used as the criterion to establish significant statistical difference between methods. No significant differences were found between the Compact Dry TC 48 and 72 h time points, with the exception of one contamination level of cooked chicken and one contamination level of dry milk

  15. How hot is too hot? Live-trapped gray wolf rectal temperatures and 1-year survival

    Science.gov (United States)

    Barber-Meyer, Shannon M.; Mech, L. David

    2014-01-01

    The ability of physically restrained and anesthetized wolves to thermoregulate is lessened and could lead to reduced survival, yet no information is available about this subject. Therefore, we analyzed rectal temperatures related to survival 1 year post-capture from 173 adult (non-pup) gray wolves (Canis lupus) captured in modified foot-hold traps for radiocollaring during June–August, 1988–2011, in the Superior National Forest of northeastern Minnesota, USA. The maximum observed rectal temperature (“maxtemp,” ° F, ° C) in each wolf during capture (x = 104.0, 40.0; SD = 2.0, 1.1; min. = 95.9, 35.5; max. = 108, 42.2) was not a significant predictor of survival to 1 year post-capture. Although no weather or morphometric variable was a significant predictor of maxtemps, wolves initially anesthetized with ketamine–xylazine rather than telazol®–xylazine averaged higher maxtemps. This information does not fully address possible effects of high body temperatures related to live-capture and handling of wolves, but it does provide a useful waypoint for future assessments of this relationship and a reassurance to wildlife practitioners that the maxtemps observed in our study did not appear to affect 1-year survival.

  16. Extension of mental preparation positively affects motor imagery as compared to motor execution: a functional near-infrared spectroscopy study.

    Science.gov (United States)

    Holper, Lisa; Scholkmann, Felix; Shalóm, Diego E; Wolf, Martin

    2012-05-01

    Motor imagery (MI) is widely used to study cognitive action control. Although, the neural simulation theory assumes that MI and motor execution (ME) share many common features, the extent of similarity and whether it spreads into the preparation phase is still under investigation. Here we asked, whether an extension of physiological mental preparation has a comparable effect on MI and ME. Data were recorded using wireless functional near-infrared spectroscopy (fNIRS) in a two-stage task design where subjects were cued with or without preparatory stimuli to either execute or imagine complex sequential thumb-finger tasks. The main finding is that the extended mental preparation has a significant positive effect on oxy-hemoglobin (∆[O(2)Hb]) in response to MI, which is proportionally larger as that found in response to ME. Furthermore, fNIRS was capable to discriminate within each task whether it was preceded by preparatory stimuli or not. Transition from mental preparation to actual performance (ME or MI) was reflected by a dip of the fNIRS signal presumably related to underlying cortical processes changing between preparation and task performance. Statistically significant main effects of 'Preparation' and 'Task' showed that ∆[O(2)Hb] during preparation was preparation-specific, i.e., positively affected by the presence of preparatory stimuli, whereas during task performance ∆[O(2)Hb] was both preparation- and task-specific, i.e., additionally affected by the task mode. These results are particularly appealing from a practical point of view for making use of MI in neuroscientific applications. Especially neurorehabilitation and neural interfaces may benefit from utilizing positive interactions between mental preparation and MI performance.

  17. Adapting Agriculture Platforms for Nutrition: A Case Study of a Participatory, Video-Based Agricultural Extension Platform in India

    Science.gov (United States)

    Kadiyala, Suneetha; Morgan, Emily H.; Cyriac, Shruthi; Margolies, Amy; Roopnaraine, Terry

    2016-01-01

    Successful integration of nutrition interventions into large-scale development programmes from nutrition-relevant sectors, such as agriculture, can address critical underlying determinants of undernutrition and enhance the coverage and effectiveness of on-going nutrition-specific activities. However, evidence on how this can be done is limited. This study examines the feasibility of delivering maternal, infant, and young child nutrition behaviour change communication through an innovative agricultural extension programme serving nutritionally vulnerable groups in rural India. The existing agriculture programme involves participatory production of low-cost videos promoting best practices and broad dissemination through village-level women’s self-help groups. For the nutrition intervention, 10 videos promoting specific maternal, infant, and young child nutrition practices were produced and disseminated in 30 villages. A range of methods was used to collect data, including in-depth interviews with project staff, frontline health workers, and self-help group members and their families; structured observations of mediated video dissemination sessions; nutrition knowledge tests with project staff and self-help group members; and a social network questionnaire to assess diffusion of promoted nutrition messages. We found the nutrition intervention to be well-received by rural communities and viewed as complementary to existing frontline health services. However, compared to agriculture, nutrition content required more time, creativity, and technical support to develop and deliver. Experimentation with promoted nutrition behaviours was high, but sharing of information from the videos with non-viewers was limited. Key lessons learned include the benefits of and need for collaboration with existing health services; continued technical support for implementing partners; engagement with local cultural norms and beliefs; empowerment of women’s group members to champion

  18. Studies on the control of cell wall extension. Yearly progress report, September 1, 1978-August 31, 1979

    Energy Technology Data Exchange (ETDEWEB)

    Cleland, R. E.

    1979-01-01

    Research has been centered around the question as to how plant cell enlargement is controlled and regulated at the cellular level. Progress is reported on the following projects: proton permeability of plant cuticles; the control of osmoregulation in Avena coleoptiles; an analysis of the acid-extension curves. (ACR)

  19. Oral fingolimod (FTY720) in multiple sclerosis: two-year results of a phase II extension study

    DEFF Research Database (Denmark)

    O'Connor, P; Comi, G; Montalban, X;

    2009-01-01

    OBJECTIVE: To report the results of a 24-month extension of a phase II trial assessing the efficacy, safety, and tolerability of the once-daily oral sphingosine-1-phosphate receptor modulator, fingolimod (FTY720), in relapsing multiple sclerosis (MS). METHODS: In the randomized, double-blind, pla...

  20. Using Extensible Markup Language (XML) for the Single Source Delivery of Educational Resources by Print and Online: A Case Study

    Science.gov (United States)

    Walsh, Lucas

    2007-01-01

    This article seeks to provide an introduction to Extensible Markup Language (XML) by looking at its use in a single source publishing approach to the provision of teaching resources in both hardcopy and online. Using the development of the International Baccalaureate Organisation's online Economics Subject Guide as a practical example, this…

  1. Prediction of mortality 1 year after hospital admission.

    LENUS (Irish Health Repository)

    Kellett, J

    2012-09-01

    Hospital admission, especially for the elderly, can be a seminal event as many patients die within a year. This study reports the prediction of death within a year of admission to hospital of the Simple Clinical Score (SCS) and ECG dispersion mapping (ECG-DM). ECG-DM is a novel technique that analyzes low-amplitude ECG oscillations and reports them as the myocardial micro-alternation index (MMI).

  2. Health problems presented to family practices in the Netherlands 1 year before and 1 year after a disaster.

    NARCIS (Netherlands)

    Soeteman, R.J.; Yzermans, C.J.; Kerssens, J.J.; Dirkzwager, A.J.; Donker, G.A.; Veen, P.M. ten; Bosch, W.J.H.M. van den; Zee, J. van der

    2007-01-01

    BACKGROUND: Disasters often have negative health consequences. Studies of health problems presented in family practice before and after a disaster are rare. The present study analyzed health problems before and after a disaster and predictors of increased morbidity after the disaster as presented in

  3. Multilayer Multidimensional Extension Set Theory

    Institute of Scientific and Technical Information of China (English)

    CAO Shao-zhong; YANG Guo-wei; TU Xu-yan

    2006-01-01

    In order to study the contradiction problem of multilayer multidimensional complex systems, the concepts of extension field and stable field of intersection and union of multilayer multidimensional extension set are given. Then the related operations and properties are discussed. The results of study expand the concepts of intersection and union of extension set to a general situation, and provide the theoretical basis for production of the concepts of intersection and union of multilayer multidimensional matter element system extension set. In this way, it will be possible that matter element system theory is used to creative designs of complex systems.

  4. ALGEBRAIC EXTENSION OF *-A OPERATOR

    Institute of Scientific and Technical Information of China (English)

    左红亮; 左飞

    2014-01-01

    In this paper, we study various properties of algebraic extension of∗-A operator. Specifically, we show that every algebraic extension of∗-A operator has SVEP and is isoloid. And if T is an algebraic extension of∗-A operator, then Weyl’s theorem holds for f (T ), where f is an analytic functions on some neighborhood of σ(T ) and not constant on each of the components of its domain.

  5. A study on the optimization of plant life extension and decommissioning for the improvement of economy in nuclear power plant

    Energy Technology Data Exchange (ETDEWEB)

    Shin, Jae In; Jung, K. J.; Chung, U. S.; Baik, S. T.; Park, S. K.; Lee, D. G.; Kim, H. R.; Park, B. Y

    2001-01-01

    Fundamental concepts on the life extension of the nuclear power plant and decommissioning optimization were established from the domestic abroad information and case analyses. Concerning the decommissioning of the nuclear power plant, the management according to decommissioning stages was analyzed by the investigation of the standard of the decommissioning(decontamination dismantling) regulation. Moreover, basics were set for the decommissioning of domestic nuclear power plants and research reactors from the analyses on the decommissioning technology and precedence.

  6. Studies on crack extension in solid propellant%固体推进剂裂纹扩展研究综述

    Institute of Scientific and Technical Information of China (English)

    胡松启; 周宴星; 刘迎吉; 陈静

    2012-01-01

    The research status of the crack extension in solid propellant at home and abroad are introduced. Experimental study and theoretical analysis of the crack extension in solid propellant are summarized. The advantages and disadvantages of such study are analyzed. The influences of various factors on crack extension in solid propellant are generalized. The results show that the tension ma- chine and high-speed photography are main means for studying the mechanics characteristic of pro- pellant with crack, and the combustion property of propellant and the extension of crack; the working pressure in combustion chamber, pressure boost rate, style and size of crack, and burning rate of pro- pellant arc the important factors for the crack extension in solid propellant. It is pointed out that it is necessary to research the quantitative relationship between various factors and crack extension.%介绍国内外关于固体推进剂裂纹扩展的研究现状,总结固体推进剂裂纹扩展的试验研究和理论分析方法,归纳影响固体推进剂裂纹扩展的各种因素。分析认为:采用拉伸装置研究有裂纹推进剂力学性能和利用高速摄影系统研究裂纹燃烧和扩展情况是当前主要的研究手段;发动机燃烧室内压力、升压速率、裂纹形状尺寸和推进剂燃速是装药裂纹扩展的重要因素;必须进一步开展各因素和裂纹扩展的定量关系研究。

  7. Effect of knee joint icing on knee extension strength and knee pain early after total knee arthroplasty: a randomized cross-over study

    DEFF Research Database (Denmark)

    Holm, Bente; Husted, Henrik; Kehlet, Henrik

    2012-01-01

    Objective: To investigate the acute effect of knee joint icing on knee extension strength and knee pain in patients shortly after total knee arthroplasty.Design: A prospective, single-blinded, randomized, cross-over study.Setting: A fast-track orthopaedic arthroplasty unit at a university hospital...

  8. Lifestyle-Related Factors Contributing to Decline in Knee Extension Strength among Elderly Women: A Cross-Sectional and Longitudinal Cohort Study.

    Directory of Open Access Journals (Sweden)

    Narumi Kojima

    Full Text Available This cross-sectional and 4-year longitudinal cohort study aimed to clarify how various lifestyle-related variables affect knee extension strength in elderly Japanese women. The participants were community-dwelling women (n = 575 living in the Itabashi Ward of Tokyo, Japan aged 75-85 years at baseline (in 2008 who returned for a follow-up examination 4 years later (in 2012. Maximum isometric knee extension strength in the dominant leg was measured during comprehensive medical check-ups at baseline and follow-up. Interviews with participants included questions on their history of 11 diseases and lifestyle-related factors such as physical activity as well as dietary, smoking, and drinking habits. Cross-sectional and longitudinal analyses yielded inconsistent results regarding the associations between lifestyle-related factors and knee extension strength. While going out more frequently and regular physical exercise positively affected baseline knee extension strength, they did not affect knee extension strength in the longitudinal analysis. The longitudinal analysis revealed that more frequent intake of soy products or green and yellow vegetables at baseline decreased age-related knee extension strength decline. The inconsistent results from the cross-sectional and longitudinal analyses indicate that conducting both types of analyses is crucial for researching this type of subject. The present study demonstrates that the age-related decline in muscle strength is lower in those who frequently eat soy products or green and yellow vegetables. Thus, recommending higher intake of soy products, and green and yellow vegetables for the elderly might help maintain their muscle health.

  9. Incidence of Acute Diarrhea Among Children Aged 0 - 1 Year in Southern Brazil, 2012

    Directory of Open Access Journals (Sweden)

    Nascimento

    2015-09-01

    Full Text Available Background The incidence rate of acute diarrheal disease in children is a health indicator, and the estimation of these data can help guide public health policies. Objectives The aim of this study was to estimate the incidence and risk factors for acute diarrheal disease in children aged 0 - 1 year. Patients and Methods An observational prospective cohort study was conducted on 210 children recruited at Hospital Nossa Senhora da Conceicao, in Tubarao, state of Santa Catarina, Brazil. Children born between July and September 2012 were followed up for 12 months. The presence of three or more liquid or loose stools during a 24-hour period was considered acute diarrhea. The categories of variables evaluated were comprised of sociodemographic characteristics (per capita income, maternal education, maternal age, access to medical care [public or private], and housing and living conditions [sanitation and hygiene, water supply, daycare attendance, and domestic animal] and characteristics of the child (gender, birth weight, and breastfeeding. Results The incidence of acute diarrhea among the 0 - 1-year-old children was 26.7 cases per 1,000 children per month. Independent risk factors for the occurrence of diarrhea were maternal age under 20 years and health care services provided by the Brazilian National Health System (SUS. Conclusions The high incidence density of diarrhea among the children recruited in this study indicates the need for educational programs directed at people who are involved in this issue.

  10. A comparison of emission calculations using different modeled indicators with 1-year online measurements.

    Science.gov (United States)

    Lengers, Bernd; Schiefler, Inga; Büscher, Wolfgang

    2013-12-01

    The overall measurement of farm level greenhouse gas (GHG) emissions in dairy production is not feasible, from either an engineering or administrative point of view. Instead, computational model systems are used to generate emission inventories, demanding a validation by measurement data. This paper tests the GHG calculation of the dairy farm-level optimization model DAIRYDYN, including methane (CH₄) from enteric fermentation and managed manure. The model involves four emission calculation procedures (indicators), differing in the aggregation level of relevant input variables. The corresponding emission factors used by the indicators range from default per cow (activity level) emissions up to emission factors based on feed intake, manure amount, and milk production intensity. For validation of the CH₄ accounting of the model, 1-year CH₄ measurements of an experimental free-stall dairy farm in Germany are compared to model simulation results. An advantage of this interdisciplinary study is given by the correspondence of the model parameterization and simulation horizon with the experimental farm's characteristics and measurement period. The results clarify that modeled emission inventories (2,898, 4,637, 4,247, and 3,600 kg CO₂-eq. cow(-1) year(-1)) lead to more or less good approximations of online measurements (average 3,845 kg CO₂-eq. cow(-1) year(-1) (±275 owing to manure management)) depending on the indicator utilized. The more farm-specific characteristics are used by the GHG indicator; the lower is the bias of the modeled emissions. Results underline that an accurate emission calculation procedure should capture differences in energy intake, owing to milk production intensity as well as manure storage time. Despite the differences between indicator estimates, the deviation of modeled GHGs using detailed indicators in DAIRYDYN from on-farm measurements is relatively low (between -6.4% and 10.5%), compared with findings from the literature.

  11. Determinants of telomere attrition over 1 year in healthy older women: stress and health behaviors matter.

    Science.gov (United States)

    Puterman, E; Lin, J; Krauss, J; Blackburn, E H; Epel, E S

    2015-04-01

    Telomere length, a reliable predictor of disease pathogenesis, can be affected by genetics, chronic stress and health behaviors. Cross-sectionally, highly stressed postmenopausal women have shorter telomeres, but only if they are inactive. However, no studies have prospectively examined telomere length change over a short period, and if rate of attrition is affected by naturalistic factors such as stress and engagement in healthy behaviors, including diet, exercise, and sleep. Here we followed healthy women over 1 year to test if major stressors that occurred over the year predicted telomere shortening, and whether engaging in healthy behaviors during this period mitigates this effect. In 239 postmenopausal, non-smoking, disease-free women, accumulation of major life stressors across a 1-year period predicted telomere attrition over the same period-for every major life stressor that occurred during the year, there was a significantly greater decline in telomere length over the year of 35 bp (P<0.05). Yet, these effects were moderated by health behaviors (interaction B=0.19, P=0.04). Women who maintained relatively higher levels of health behaviors (1 s.d. above the mean) appeared to be protected when exposed to stress. This finding has implications for understanding malleability of telomere length, as well as expectations for possible intervention effects. This is the first study to identify predictors of telomere length change over the short period of a year.

  12. Development of 1-year-old computational phantom and calculation of organ doses during CT scans using Monte Carlo simulation.

    Science.gov (United States)

    Pan, Yuxi; Qiu, Rui; Gao, Linfeng; Ge, Chaoyong; Zheng, Junzheng; Xie, Wenzhang; Li, Junli

    2014-09-21

    With the rapidly growing number of CT examinations, the consequential radiation risk has aroused more and more attention. The average dose in each organ during CT scans can only be obtained by using Monte Carlo simulation with computational phantoms. Since children tend to have higher radiation sensitivity than adults, the radiation dose of pediatric CT examinations requires special attention and needs to be assessed accurately. So far, studies on organ doses from CT exposures for pediatric patients are still limited. In this work, a 1-year-old computational phantom was constructed. The body contour was obtained from the CT images of a 1-year-old physical phantom and the internal organs were deformed from an existing Chinese reference adult phantom. To ensure the organ locations in the 1-year-old computational phantom were consistent with those of the physical phantom, the organ locations in 1-year-old computational phantom were manually adjusted one by one, and the organ masses were adjusted to the corresponding Chinese reference values. Moreover, a CT scanner model was developed using the Monte Carlo technique and the 1-year-old computational phantom was applied to estimate organ doses derived from simulated CT exposures. As a result, a database including doses to 36 organs and tissues from 47 single axial scans was built. It has been verified by calculation that doses of axial scans are close to those of helical scans; therefore, this database could be applied to helical scans as well. Organ doses were calculated using the database and compared with those obtained from the measurements made in the physical phantom for helical scans. The differences between simulation and measurement were less than 25% for all organs. The result shows that the 1-year-old phantom developed in this work can be used to calculate organ doses in CT exposures, and the dose database provides a method for the estimation of 1-year-old patient doses in a variety of CT examinations.

  13. Prognostic factors for weight loss over 1-year period in patients recently diagnosed with mild Alzheimer Disease

    DEFF Research Database (Denmark)

    Hansen, M.L.; Waldorff, F.B.; Waldemar, G.;

    2011-01-01

    % in 1 year for defining weight loss. The mean age at inclusion was 76.1 years. Sixty-six patients (24.6%) lost more than 4% of their body weight during the study period. A logistic regression showed that an increase of 1 baseline body mass index point significantly increased the odds of weight loss by 9......%. Furthermore, the results suggested a trend that for men, living alone was a risk factor for losing weight, whereas for women living with somebody was associated with a higher risk. However, further studies are pertinent within this area. As weight loss is a predictor of mortality in patients with AD...

  14. Extensive air showers

    CERN Document Server

    Rao, M V S

    1997-01-01

    Ultrahigh energy cosmic rays carry information about their sources and the intervening medium apart from providing a beam of particles for studying certain features of high energy interactions currently inaccessible at man-made accelerators. They can at present be studied only via the extensive air showers (EAS's) they generate while passing through the Earth's atmosphere, since their fluxes are too low for the experiments of limited capability flown in balloons and satellites. The EAS is generated by a series of interactions of the primary cosmic ray and its progeny with the atmospheric nucle

  15. Enabling the development of Community Extensions to GI-cat - the SIB-ESS-C case study

    Science.gov (United States)

    Bigagli, L.; Meier, N.; Boldrini, E.; Gerlach, R.

    2009-04-01

    GI-cat is a Java software package that implements discovery and access services for disparate geospatial resources. An instance of GI-cat provides a single point of service for querying and accessing remote, as well as local, heterogeneous sources of geospatial information, either through standard interfaces, or taking advantage of GI-cat advanced features, such as incremental responses, query feedback, etc. GI-cat supports a number of de-iure and de-facto standards, but can also be extended to additional community catalog/inventory services, by defining appropriate mediation components. The GI-cat and the SIB-ESS-C development teams collaborated in the development of a mediator to the Siberian Earth Science System Cluster (SIB-ESS-C), a web-based infrastructure to support the communities of environmental and Earth System research in Siberia. This activity resulted in the identification of appropriate technologies and internal mechanisms supporting the development of GI-cat extensions, that are the object of this work. GI-cat is actually built up of a modular framework of SOA components, that can be variously arranged to fit the needs of a community of users. For example, a particular GI-cat instance may be configured to provide discovery functionalities onto an OGC WMS; or to adapt a THREDDS catalog to the standard OGC CSW interface; or to merge a number of CDI repositories into a single, more efficient catalog. The flexibility of GI-cat framework is achieved thanks to its design, that follows the Tree of Responsibility (ToR) pattern and the Uniform Pipe and Filter architectural style. This approach allows the building of software blocks that can be flexibly reused and composed in multiple ways. In fact, the components that make up any GI-cat configuration all implement two common interfaces (i.e. IChainNode and ICatalogService), that support chaining one component to another . Hence, it would suffice to implement those interfaces (plus an appropriate factory

  16. BDNF mediates improvements in executive function following a 1-year exercise intervention

    Directory of Open Access Journals (Sweden)

    Regina Lynn Leckie

    2014-12-01

    Full Text Available Executive function declines with age, but engaging in aerobic exercise may attenuate decline. One mechanism by which aerobic exercise may preserve executive function is through the up-regulation of brain-derived neurotropic factor (BDNF, which also declines with age. The present study examined BDNF as a mediator of the effects of a 1-year walking intervention on executive function in 90 older adults (mean age = 66.82. Participants were randomized to a stretching and toning control group or a moderate intensity walking intervention group. BDNF serum levels and performance on a task-switching paradigm were collected at baseline and follow-up. We found that age moderated the effect of intervention group on changes in BDNF levels, with those in the highest age quartile showing the greatest increase in BDNF after 1-year of moderate intensity walking exercise (p = .036. The mediation analyses revealed that BDNF mediated the effect of the intervention on task-switch accuracy, but did so as a function of age, such that exercise-induced changes in BDNF mediated the effect of exercise on task-switch performance only for individuals over the age of 71. These results demonstrate that both age and BDNF serum levels are important factors to consider when investigating the mechanisms by which exercise interventions influence cognitive outcomes, particularly in elderly populations.

  17. The communal reading of comics: a case study of an extensive reading project for adult basic literacy

    Directory of Open Access Journals (Sweden)

    Esther Ramani

    2008-08-01

    Full Text Available This paper describes a piece of classroom-centred research we did into the extensive reading practices of adult basic literacy learners. The research reported here was part of a larger research project into the 'communicational' teaching of English for beginning learners inspired by the work of Prabhu (1987. Using comics supplied by The Storyteller Group, we experimented with the Prabhu/Krashen 'acquisition' approach and extended the pedagogy through trial and error, documenting the whole process with the help of video recordings and our own notes. We present four stages in this 'reading for pleasure' course with descriptions of the pedagogy and excerpts of classroom interaction. Important outcomes of this research are the creative use of language promoted by story re-telling and the desire for ownership of books by learners once they experience ownership of the story through task-based activities on the comics.

  18. Comparative Study of the Use of Extensible Business Reporting Language (XBRL in Projects for the Supervision of Banking Institutions

    Directory of Open Access Journals (Sweden)

    Myrna Berríos Pagan

    2011-08-01

    Full Text Available The objective of this research is to make a comparative analysis of the use of Extensible Business Reporting Language (XBRL in the projects undertaken for the mandatory filing of banks’ financial information in the United States and the European Union. The agencies overseeing these filing requirements are the Federal Financial Institutions Examination Council (FFIEC and the Committee of European Banking Supervisors (CEBS in the United States and the European Union, respectively. This comparative analysis is made for the following five dimensions: 1 project definition and scope; 2 planned project activities and responsibilities of stakeholders; 3 project management methodology and process; 4 progress monitoring, deadlines, and milestones; and 5 outcomes in terms of project goals and objectives.

  19. Case study of a commercial sheep flock under extensive mountain grazing: Pasture derived lipid compounds in milk and cheese.

    Science.gov (United States)

    Valdivielso, I; Bustamante, M A; Aldezabal, A; Amores, G; Virto, M; Ruiz de Gordoa, J C; de Renobales, M; Barron, L J R

    2016-04-15

    Terpenoid, fat-soluble antioxidant and fatty acid (FA) composition of pasture as well as those of milk and cheese from a commercial sheep flock managed under extensive mountain grazing in the east region of the Cantabrian mountain (Northern Spain) was investigated. The grazing period lasted for 2 months and ewes were at late lactation stage. Plants, feces, bulk milk and cheese samples were collected on two sampling dates. The abundance of the dominating botanical families in the mountain pasture prevailed in the sheep diet of the commercial flock. Major terpenoids and tocols in the pasture appeared as major ones in milk and cheese, whereas C18 unsaturated FAs in milk and cheese were derived from the intake of C18 polyunsaturated FAs which were prevalent in the pasture. No carotene was detected in the dairy samples but retinol (free or esterified), derived from the intake of β-carotene present in pasture plants, was found in milk and cheese.

  20. 森田疗法对精神分裂症患者自尊水平和生活满意度的1年随访%Effect of Morita Therapy on Self-esteem and Life Satisfaction for Schizophrenia:1 Year Follow-up Study

    Institute of Scientific and Technical Information of China (English)

    周依文; 周一平

    2014-01-01

    Objective To observe the effect of Morita therapy on self-esteem level and life satisfaction in schizophrenic patients. Meth-ods 140 schizophrenic patients received Morita therapy, and followed up for 1 year. Self-esteem Scale (SES), Life Satisfaction Index B (LSIB), and Personal and Social Performance scale (PSP) were evaluated. Results The scores of SES and LSIB significantly improved after treatment (P=0.000). 117 cases (83.57%) were in stable condition;20 cases (14.29%) were in unstable condition with poor medication com-pliance;only 3 cases (2.14%) needed to be re-hospitalized due to relapse. The 117 cases were followed up for 1 year, and their SES and LSIB scores maintained at the level when discharge, in which 94 cases kept in well social function. Conclusion Morita therapy can improve the self-esteem and life satisfaction of schizophrenic patients, and maintain good social function.%目的:观察森田疗法对精神分裂症患者自尊水平、生活满意度和社会功能的效果。方法对140例精神分裂症患者在住院期间应用森田疗法理论指导,出院后跟踪随访1年,采用自尊量表(SES)、生活满意度指数B(LSIB)和出院后个人和社会表现量表(PSP)进行评定。结果治疗后,康复期精神分裂症患者SES评分和LSIB评分有显著提高(P=0.000)。出院后117例(83.57%)病情稳定;20例(14.29%)出现服药依从性差,病情不稳定,3例(2.14%)复发再入院。对病情稳定者随访1年后,SES评分和LSIB评分均保持在出院水平;94例患者社会功能保持在良好水平以上。结论森田疗法对改善康复期精神分裂症患者的自尊水平、主观生活满意度和保持良好的社会功能有积极的临床实践意义。

  1. 2 years versus 1 year of adjuvant trastuzumab for HER2-positive breast cancer (HERA)

    DEFF Research Database (Denmark)

    Goldhirsch, Aron; Gelber, Richard D; Piccart-Gebhart, Martine J

    2013-01-01

    Trastuzumab has established efficacy against breast cancer with overexpression or amplification of the HER2 oncogene. The standard of care is 1 year of adjuvant trastuzumab, but the optimum duration of treatment is unknown. We compared 2 years of treatment with trastuzumab with 1 year of treatmen......, and updated the comparison of 1 year of trastuzumab versus observation at a median follow-up of 8 years, for patients enrolled in the HERceptin Adjuvant (HERA) trial....

  2. Compression-extension transition of continental crust in a subduction zone: A parametric numerical modeling study with implications on Mesozoic-Cenozoic tectonic evolution of the Cathaysia Block

    Science.gov (United States)

    Chan, Lung Sang; Gao, Jian-Feng

    2017-01-01

    The Cathaysia Block is located in southeastern part of South China, which situates in the west Pacific subduction zone. It is thought to have undergone a compression-extension transition of the continental crust during Mesozoic-Cenozoic during the subduction of Pacific Plate beneath Eurasia-Pacific Plate, resulting in extensive magmatism, extensional basins and reactivation of fault systems. Although some mechanisms such as the trench roll-back have been generally proposed for the compression-extension transition, the timing and progress of the transition under a convergence setting remain ambiguous due to lack of suitable geological records and overprinting by later tectonic events. In this study, a numerical thermo-dynamical program was employed to evaluate how variable slab angles, thermal gradients of the lithospheres and convergence velocities would give rise to the change of crustal stress in a convergent subduction zone. Model results show that higher slab dip angle, lower convergence velocity and higher lithospheric thermal gradient facilitate the subduction process. The modeling results reveal the continental crust stress is dominated by horizontal compression during the early stage of the subduction, which could revert to a horizontal extension in the back-arc region, combing with the roll-back of the subducting slab and development of mantle upwelling. The parameters facilitating the subduction process also favor the compression-extension transition in the upper plate of the subduction zone. Such results corroborate the geology of the Cathaysia Block: the initiation of the extensional regime in the Cathaysia Block occurring was probably triggered by roll-back of the slowly subducting slab. PMID:28182640

  3. A 1-year follow-up study on the drug use pattern of heroin addicts who return to society after detoxification%海洛因依赖者戒毒回归社会后一年转归情况随访研究

    Institute of Scientific and Technical Information of China (English)

    江海峰; 李质彬; 杜江; 潘淑均; 陈红; 钟娜; 赵敏

    2013-01-01

    目的 了解海洛因依赖者戒毒回归社会后1年内药物滥用的结局与转归,分析海洛因依赖者戒断后1年复吸的预后因素.方法 使用自制个案调查表、应激感觉量表(PSS)和成瘾行为严重度指数量表(ASI)对563例回归社会后1年的海洛因依赖者进行访谈评估,并使用自然病程问卷(NHI)跟踪随访1年内复吸发生情况,对操守时间进行生存分析.结果 共249例完成1年随访面谈,其中发生复吸者为111例(44.6%),平均操守时间为(8.3±0.3)个月;复吸者心理渴求程度[(3.69±3.60)分∶(0.40±1.46)分;P<0.01]、PSS评分[(19.0±4.7)分∶(17.6±4.6)分;P<0.05]及ASI的躯体状况[0.00(0.00 ~0.33)分∶0.00(0.00 ~0.02)分;P<0.01]、就业状况[(0.83±0.27)分∶(0.67±0.30)分;P<0.01]、毒品使用状况[0.14(0.00 ~0.25)分∶0.00(0.00 ~ 0.00)分;P<0.01]、酒精滥用情况[0.00(0.00 ~0.08)分∶0.00(0.00 ~0.00)分;P<0.05]、法律状况[(0.00(0.00 ~0.05)分∶0.00(0.00 ~0.00)分;P<0.01]、家庭支持[0.13(0.04 ~0.26)分∶0.10(0.00 ~0.18)分;P<0.01]和精神状况[0.00(0.09 ~0.36)分∶0.00(0.00 ~0.00)分;P<0.01]因子分均高于操守者;Cox回归分析显示,基线心理渴求程度是复吸的危险因素(OR=1.226,P<0.01).结论 海洛因依赖者戒毒后回归社会后1年内发生复吸行为比例高,有无发生复吸的海洛因依赖者具有不同的临床特征,降低毒品的心理渴求程度可降低回归社会后复吸的风险.%Objective To examine the drug use pattern of detoxificated heroin addicts after 1 year from return to society after detoxification,and to identify predictors of relapse.Methods 563 heroin addicts were accessed by case questionnaire and the Perceived Stress Scall(PPS),Addiction Severity Index (ASI),and followed after 1 year by the Nature History Interview (NHI) from return to society after detoxification."Relapse" was defined as any heroin use during 1 year

  4. Evaluation of laryngoscopic view, intubation difficulty and sympathetic response during direct laryngoscopy in sniffing position and simple head extension: a prospective and randomized comparative study

    OpenAIRE

    Rashmi Pal; Sangeeta Chauhan; Bhanu Kumar Ved; Shankar Rao Lad

    2015-01-01

    Background: Airway management is critical to the care of patients and direct laryngoscopy is the mainstay of airway management. Despite the proliferation of difficult airway devices, sniffing position for laryngoscopy remains the gold standard and ideal position. This prospective, randomized and single-blind study was done to evaluate and compare the laryngoscopic view, complexity of intubation and sympathetic response during laryngoscopy in sniffing position and simple head extension. Met...

  5. Experimental Study of Crack Initiation and Extension Induced by Hydraulic Fracturing in a Tree-Type Borehole Array

    Directory of Open Access Journals (Sweden)

    Yiyu Lu

    2016-06-01

    Full Text Available High-pressure hydraulic fracturing technology in coal and coal bed methane mines can lead to roof and floor damage, and fracture initiation disorder that leads to a “blank area”, and other issues. A new method of hydraulic fracturing is proposed to increase the homogeneous permeability of coal in underground coalmines. Numerical and other simulation tests for different forms of a tree-type, branched borehole model are presented. The results show that the branched array causes cracks to initiate from the bottom of the array, and these extend along the direction of the adjacent boreholes. Generally, as the number of branched boreholes increases, the coal seam fracture network also increase, improving the distribution of the fracture network, making the fracturing effect better. The branched boreholes appear to reduce initiation pressure and, with increasing branches, the initiation pressure decreases. A model with four tree-type, branched boreholes leads to a reduction in initiation pressure of 69%. In terms of permeability improvement technology in underground coalmines, a branched hydraulic fracturing borehole array has the advantages of reducing initiation pressure, controlling crack initiation and extension, enhancing the fracturing effect and reducing the destruction of the roof and floor.

  6. Genetic evaluation of weaning weight and probability of lambing at 1 year of age in Targhee lambs

    Science.gov (United States)

    The objective of this study was to investigate genetic control of 120-day weaning weight and the probability of lambing at 1 year of age in Targhee ewe lambs. Records of 5,967 ewe lambs born from 1989 to 2012 and first exposed to rams for breeding at approximately 7 months of age were analyzed. Reco...

  7. Immediate Single-Tooth Implant Placement in Bony Defects in the Esthetic Zone : A 1-Year Randomized Controlled Trial

    NARCIS (Netherlands)

    Slagter, Kirsten W.; Meijer, Henny J. A.; Bakker, Nicolaas A.; Vissink, Arjan; Raghoebar, Gerry M.

    2016-01-01

    Background: This study aims to assess, with regard to marginal bone level (MBL), whether the outcome of immediate implant placement in bony defects in the esthetic zone was non-inferior to delayed implant placement after 1 year. Methods: Forty patients with a failing tooth in the esthetic zone and a

  8. A simple risk score predicts poor quality of life and non-survival at 1 year follow-up in dialysis patients

    NARCIS (Netherlands)

    de Jonge, P; Ruinemans, GMF; Huyse, FJ; ter Wee, PM

    2003-01-01

    Background. Quality of life (QoL) in end-stage renal disease patients has become an important focus of attention in evaluating dialysis. We studied risk factors of poor QoL at 1 year follow-up. Methods. Of a baseline sample of 80 dialysis patients, we contacted 60 patients who were alive at 1 year f

  9. Patient-centeredness and quality management in Dutch diabetes care organizations after a 1-year intervention

    Science.gov (United States)

    Campmans-Kuijpers, Marjo JE; Lemmens, Lidwien C; Baan, Caroline A; Rutten, Guy EHM

    2016-01-01

    Background More focus on patient-centeredness in care for patients with type 2 diabetes requests increasing attention to diabetes quality management processes on patient-centeredness by managers in primary care groups and outpatient clinics. Although patient-centered care is ultimately determined by the quality of interactions between patients and clinicians at the practice level, it should be facilitated at organizational level too. This nationwide study aimed to assess the state of diabetes quality management on patient-centeredness at organizational level and its possibilities to improve after a tailored intervention. Methods This before–after study compares the quality management on patient-centeredness within Dutch diabetes care groups and outpatient clinics before and after a 1-year stepwise intervention. At baseline, managers of 51 diabetes primary care groups and 28 outpatient diabetes clinics completed a questionnaire about the organization’s quality management program. Patient-centeredness (0%–100%) was operationalized in six subdomains: facilitating self-management support, individualized care plan support, patients’ access to medical files, patient education policy, safeguarding patients’ interests, and formal patient involvement. The intervention consisted of feedback and benchmark and if requested a telephone call and/or a consultancy visit. After 1 year, the managers completed the questionnaire again. The 1-year changes were examined by dependent (non) parametric tests. Results Care groups improved significantly on patient-centeredness (from 47.1% to 53.3%; P=0.002), and on its subdomains “access to medical files” (from 42.0% to 49.4%), and “safeguarding patients’ interests” (from 58.1% to 66.2%). Outpatient clinics, which scored higher at baseline (66.7%) than care groups, did not improve on patient-centeredness (65.6%: P=0.54) or its subdomains. “Formal patient involvement” remained low in both care groups (23.2%) and

  10. Patient-centeredness and quality management in Dutch diabetes care organizations after a 1-year intervention

    Directory of Open Access Journals (Sweden)

    Campmans-Kuijpers MJ

    2016-10-01

    Full Text Available Marjo JE Campmans-Kuijpers,1 Lidwien C Lemmens,2 Caroline A Baan,2 Guy EHM Rutten1 1Julius Centre for Health Sciences and Primary Care, University Medical Centre Utrecht, Utrecht, 2Centre for Nutrition, Prevention and Health Services, National Institute of Public Health and the Environment, Bilthoven, Utrecht, the Netherlands Background: More focus on patient-centeredness in care for patients with type 2 diabetes requests increasing attention to diabetes quality management processes on patient-centeredness by managers in primary care groups and outpatient clinics. Although patient-centered care is ultimately determined by the quality of interactions between patients and clinicians at the practice level, it should be facilitated at organizational level too. This nationwide study aimed to assess the state of diabetes quality management on patient-centeredness at organizational level and its possibilities to improve after a tailored intervention.Methods: This before–after study compares the quality management on patient-centeredness within Dutch diabetes care groups and outpatient clinics before and after a 1-year stepwise intervention. At baseline, managers of 51 diabetes primary care groups and 28 outpatient diabetes clinics completed a questionnaire about the organization’s quality management program. Patient-centeredness (0%–100% was operationalized in six subdomains: facilitating self-management support, individualized care plan support, patients’ access to medical files, patient education policy, safeguarding patients’ interests, and formal patient involvement. The intervention consisted of feedback and benchmark and if requested a telephone call and/or a consultancy visit. After 1 year, the managers completed the questionnaire again. The 1-year changes were examined by dependent (non parametric tests.Results: Care groups improved significantly on patient-centeredness (from 47.1% to 53.3%; P=0.002, and on its subdomains “access to

  11. Evidence of Bordetella pertussis infection in vaccinated 1-year-old Danish children

    DEFF Research Database (Denmark)

    von Linstow, Marie-Louise; Pontoppidan, Peter Lotko; von König, Carl-Heinz Wirsing

    2010-01-01

    We measured IgA and IgG antibodies to pertussis toxin (PT) and filamentous hemagglutinin (FHA) in sera from 203 1-year-old children who had received one to three doses of a monocomponent PT toxoid vaccine. Ten children (5%) had IgA antibody to PT indicating recent infection; seven of these children...... had received three doses of vaccine. PT IgA responders did not have significantly longer coughing episodes than PT IgA non-responders. Since an IgA antibody response occurs in only approximately 50% of infected children, the actual infection rate in our cohort is estimated to approximately 10......%. The apparent high Bordetella pertussis infection rate in Danish infants suggests that the monocomponent PT toxoid vaccine used in Denmark has limited efficacy against B. pertussis infection. A prospective immunization study comparing a multi-component vaccine with the present monocomponent PT toxoid vaccine...

  12. 1-Year Outcomes of FFRCT-Guided Care in Patients With Suspected Coronary Disease

    DEFF Research Database (Denmark)

    Douglas, Pamela S; De Bruyne, Bernard; Pontone, Gianluca;

    2016-01-01

    BACKGROUND: Coronary computed tomographic angiography (CTA) plus estimation of fractional flow reserve using CTA (FFRCT) safely and effectively guides initial care over 90 days in patients with stable chest pain. Longer-term outcomes are unknown. OBJECTIVES: The study sought to determine the 1-year...... clinical, economic, and quality-of-life (QOL) outcomes of using FFRCT instead of usual care. METHODS: Consecutive patients with stable, new onset chest pain were managed by either usual testing (n = 287) or CTA (n = 297) with selective FFRCT (submitted in 201, analyzed in 177); 581 of 584 (99.5%) completed...... events were infrequent, with 2 in each arm of the planned invasive group and 1 in the planned noninvasive cohort (usual care strategy). In the planned invasive stratum, mean costs were 33% lower with CTA and selective FFRCT ($8,127 vs. $12,145 usual care; p

  13. Substance use disorder counselors' job performance and turnover after 1 year: linear or curvilinear relationship?

    Science.gov (United States)

    Laschober, Tanja C; de Tormes Eby, Lillian Turner

    2013-07-01

    The main goals of the current study were to investigate whether there are linear or curvilinear relationships between substance use disorder counselors' job performance and actual turnover after 1 year utilizing four indicators of job performance and three turnover statuses (voluntary, involuntary, and no turnover as the reference group). Using longitudinal data from 440 matched counselor-clinical supervisor dyads, results indicate that overall, counselors with lower job performance are more likely to turn over voluntarily and involuntarily than not to turn over. Further, one of the job performance measures shows a significant curvilinear effect. We conclude that the negative consequences often assumed to be "caused" by counselor turnover may be overstated because those who leave both voluntarily and involuntarily demonstrate generally lower performance than those who remain employed at their treatment program.

  14. 双相情感障碍I型患者病情缓解后认知功能的1年随访研究%Cognitive function in euthymic Patients with biPolar I disorder:a 1-year follow-uP study

    Institute of Scientific and Technical Information of China (English)

    沈辉; 张毅; 陈美娟; 费慧; 钱时兴

    2014-01-01

    Objective:To explore the characteristic of the impairment of cognitive function in patients with bipolar I disorder(BD-I). Method:Sixty-six euthymic patients with BD-I and 66 healthy-matched con-trols were cognitively assessed twice over a 1-year follow-up. The patients were in euthymic during the both eval-uations. Cognitive assessment were performed by using digit symbol,digit span,trail making test( TMT)and Wisconsin card sorting test(WSCT). Results:①The results of digit symbol,digit span,TMT and WSCT were significantly poorer in BD-I patients than in normal controls(all P ﹤ 0. 01). Such deficits were maintained over a 1-year period(P ﹥ 0. 02). ②In BD-I patients,digit span,TMT-A and digit symbol were significantly correlated with duration of illness(P ﹤ 0. 02 or P ﹤ 0. 01). Digit forward,TMT-A and digit symbol were significantly corre-lated with current job situation(P ﹤ 0. 02 or P ﹤ 0. 01). None of the indexes of cognitive function were signifi-cantly correlated with length of euthymia or the age of onset(P ﹥ 0. 02). Conclusion:Cognitive functions,in-cluding attention,memory and executive function are impaired in BD-I patients. This impairment is maintained but does not worsen over 1-year period.%目的:探讨双相情感障碍 I 型患者认知功能的损害特点。方法:纳入66例缓解期双相情感障碍 I 型患者和66名正常对照者,随访1年,分别采用数字符号、数字广度(顺背、倒背)、连线测验 A (TMT-A)、连线测验 B(TMT-B)和威斯康星卡片分类测验(WCST)评定,比较基线和1年后认知功能的变化。两次评定时要求患者均处于缓解期。结果:①患者组数字符号、数字广度(顺背、倒背)、TMT-A、TMT-B 和 WSCT(总错误数和持续错误数)成绩均差于正常对照组(P 均﹤0.01),1年后这种损害持续存在,并且保持稳定不变(P ﹥0.02)。②患者组顺背、倒背、TMT-A 和数字符号

  15. An Economic Evaluation of Iranian Horticultural Research and Extension Policy: The Case Study of Almond Late Flowering Cultivars

    Directory of Open Access Journals (Sweden)

    Seyed Safdar Hosseini

    2013-09-01

    Full Text Available This paper examines the economic effects of investment in developing and introducing Almond Late Flowering Cultivars (ALFC in a period of 52 years from 1968 to 2020, developed in Sahand Horticultural Research Station (SHRS, using the economic surplus model and field survey data. ALFC make almond supply curve move less to the left when there is a chilling case, thus affect the economic surplus of producers and consumers. Results showed that because of ALFC, economic surplus of producers and consumers had been increased about 0.4 and 0.6 million US Dollars, respectively that the share of consumers from benefits was 58 percent. The social net present value of ALFC regarding to the cost of research and extension was about 0.1 million US Dollars. It was identified that the internal rate of return in developing and introducing of ALFC had been about 11%. The findings expressed that if the research investment in ALFC could keep the position of almond supply curve unchanged unless the weather conditions, then the economic surplus of producers and consumers would decreased 3 and 4.2 million US Dollars less annually, respectively and internal rate of return in almond research would be 33 %. Comparing the results showed that the introduction of late flowering cultivars could reduce the loss only 4 % per hectare. The results illustrated that investment in R&E of almond could make supply curve shift less in chilling situation because of decrease in cultivation cost, but it is necessary to enhance almond yield too. The findings identify that the efficiency of current system of R&E for almond is low. So it is a necessity to find ways for make better the R&E performance in Iran.

  16. Identifying groups at risk for 1-year membership termination from a fitness center at enrollment.

    Science.gov (United States)

    Hooker, Stephanie A; Ross, Kaile M; Ranby, Krista W; Masters, Kevin S; Peters, John C; Hill, James O

    2016-12-01

    The vast majority of Americans do not engage in adequate regular physical activity despite its well-known health benefits. Even when individuals attempt to become more active by joining a fitness center, estimates suggest that nearly half terminate their membership within the first 6 months. A better understanding of who is at risk for early membership termination upon joining may help researchers develop targeted interventions to improve the likelihood that individuals will successfully maintain memberships and physical activity. This study's purpose was to identify, based on a wellness assessment (WA) used in fitness centers, individuals at risk for fitness membership termination prior to 1-year. Center members (N = 441; Mage = 41.9, SD = 13.1; 74.4% female) completed a comprehensive WA of stress, life satisfaction, physical fitness, metabolic health, and sleep quality at the beginning of their memberships and were followed for one year. Latent class analyses utilized the WA to identify four groups: (a) healthy, (b) unhealthy, (c) poor psychological wellness, and (d) poor physical wellness. Participants in the poor psychological wellness group (OR = 2.24, p = 0.007) and the unhealthy group (OR = 2.40, p = 0.037) were significantly more likely to terminate their memberships at 1-year as compared to the healthy group. Participants with poor physical wellness visited the fitness center less frequently than healthy participants (p psychological wellness is a risk factor for terminating memberships, whereas poor physical wellness is not. Future studies should replicate these latent classes and develop targeted interventions to address psychological wellness as a method to improve fitness membership retention.

  17. Qualitative Examination of Adolescent Health-Related Quality of Life at 1 Year Postconcussion

    Science.gov (United States)

    Iadevaia, Cheree; Roiger, Trevor; Zwart, Mary Beth

    2015-01-01

    Context Moderate to severe traumatic brain injuries can negatively influence health-related quality of life (HRQOL) in adolescent patients. The effect of sport-related concussion on adolescent HRQOL remains unclear. Objective To investigate the perceptions of adolescent student-athletes and their parents regarding the adolescents' HRQOL 1 year after sport-related concussion. Design Qualitative study. Setting Secondary school. Patients or Other Participants Seven adolescent student-athletes (age range, 12–16 years) who sustained a sport-related concussion at least 1 year (15.3 ± 2.8 months) before the study participated along with their primary care-giving parents (n = 7). Data Collection and Analysis Fourteen semistructured face-to-face interviews (7 adolescents, 7 parents) were completed. Interviews were transcribed and inductively analyzed by a team of 3 athletic trainers with 32 combined years of professional experience. Themes were negotiated through a consensual review process. Participant checks were completed to ensure trustworthiness of the results. Results Four major themes emerged from the interviews: (1) significant effect of symptoms, (2) feelings of frustration, (3) influence on school attendance and activities, and (4) nature of interpersonal and team relationships. Participants indicated that the physical symptoms of the concussion substantially affected their emotional and academic function. The influence of the concussion on social interactions seemed to depend on the nature of interpersonal relationships. Conclusions Sport-related concussion can negatively influence physical and emotional function, academics, and interpersonal interactions as perceived by adolescent student-athletes and their parents. Education of parents and their children, school professionals, coaches, and teammates remains critical to effectively recognize and manage sport-related concussion. Secondary school districts also play a critical role in the concussion

  18. Identifying groups at risk for 1-year membership termination from a fitness center at enrollment

    Directory of Open Access Journals (Sweden)

    Stephanie A. Hooker

    2016-12-01

    Full Text Available The vast majority of Americans do not engage in adequate regular physical activity despite its well-known health benefits. Even when individuals attempt to become more active by joining a fitness center, estimates suggest that nearly half terminate their membership within the first 6 months. A better understanding of who is at risk for early membership termination upon joining may help researchers develop targeted interventions to improve the likelihood that individuals will successfully maintain memberships and physical activity. This study's purpose was to identify, based on a wellness assessment (WA used in fitness centers, individuals at risk for fitness membership termination prior to 1-year. Center members (N = 441; Mage = 41.9, SD = 13.1; 74.4% female completed a comprehensive WA of stress, life satisfaction, physical fitness, metabolic health, and sleep quality at the beginning of their memberships and were followed for one year. Latent class analyses utilized the WA to identify four groups: (a healthy, (b unhealthy, (c poor psychological wellness, and (d poor physical wellness. Participants in the poor psychological wellness group (OR = 2.24, p = 0.007 and the unhealthy group (OR = 2.40, p = 0.037 were significantly more likely to terminate their memberships at 1-year as compared to the healthy group. Participants with poor physical wellness visited the fitness center less frequently than healthy participants (p < 0.01. Results suggest that poor psychological wellness is a risk factor for terminating memberships, whereas poor physical wellness is not. Future studies should replicate these latent classes and develop targeted interventions to address psychological wellness as a method to improve fitness membership retention.

  19. Phase II study of a 3-day schedule with topotecan and cisplatin in patients with previously untreated small cell lung cancer and extensive disease

    DEFF Research Database (Denmark)

    Sorensen, M.; Lassen, Ulrik Niels; Jensen, Peter Buhl;

    2008-01-01

    and cisplatin are needed. The aim of this phase II study was to establish the response rate and response duration in chemo-naive patients with SCLC receiving a 3-day topotecan and cisplatin schedule. METHODS: Simons optimal two-stage design was used. Patients with previously untreated extensive disease SCLC......, adequate organ functions and performance status less than 3 were eligible. Topotecan (2.0 mg/m, intravenously) was administered on days 1 to 3 with cisplatin (50 mg/m, intravenously) on day 3 every 3 weeks for a total of six cycles. RESULTS: Forty-three patients received 219 cycles of chemotherapy. Median.......3-7.7), respectively. CONCLUSION: Three-day topotecan with cisplatin on day 3 is active and safe in extensive disease SCLC. An ongoing phase III randomized trial compares this combination to standard treatment Udgivelsesdato: 2008/8...

  20. An Integrative Analysis of an Extensive Green Roof System: A Case Study of the Schleman Green Roof

    Science.gov (United States)

    Hoover, F.; Bowling, L. C.

    2013-12-01

    In urban environments where populations continue to rise, the need for affective stormwater management and runoff control methods is ever prevalent. Increased population growth and city expansion means greater impervious surfaces and higher rates of stormwater runoff. In well-established cities, this proves particularly difficult due to a constraining built environment and limited pervious spaces, even in cities as small as 40,000 residents. Work to reduce runoff in combined sewer systems (CSS) and municipal separated storm sewer systems (MS4) by use of best-management practices is one route currently under investigation. The Purdue University campus is making efforts to reduce their impact on the West Lafayette CSS and MS4. Green roofs are one management practice being used for runoff mitigation. Specifically, Schleman Hall, an administrative student affairs building, has a small green roof located on the second floor installed in 2008. In cooperation with Purdue Physical Facilities, monitoring and analysis for the Schleman extensive green roof at Purdue University was performed from June 2012 to December 2012. The objective was to determine the stormwater retention, output water quality and net present value for the 165 m2 roof. The results from the water balance analysis revealed retention rates on average of 58% of precipitation per rain event, where retention included soil moisture, evaporation and detention/depression storage. The water quality metrics tested were Nitrate-Nitrite (NO2-NO3), Orthophosphate (PO4), Ammonia-Ammonium ion (NH3-NH4), Sulfate (SO4), total suspended solids (TSS) and pH. The pollutant concentration and load results varied, but the pH levels from precipitation increased in all samples after passing through the substrate. SO4 and PO4 results yielded higher concentrations and loads in the green roof output than the control output and precipitation, while NO2-NO3 and NH3-NH4 yielded concentrations and loads that were reduced by the green

  1. An Evaluation of the Mulligan Stew 4-H Television Series for Extension Service, USDA. Volume II: Report of the Study.

    Science.gov (United States)

    Shapiro, Sydelle Stone; And Others

    Conducted on over 3,000 fourth, fifth, and sixth grade children in six states, this study documents changes in nutrition-related knowledge and behaviors which can be related to participating in the Mulligan Stew television series. This volume is a detailed elaboration of the study findings as well as a description of the study design,…

  2. Bone mineral density in rheumatoid arthritis patients 1 year after adalimumab therapy: arrest of bone loss

    Science.gov (United States)

    Wijbrandts, C A; Klaasen, R; Dijkgraaf, M G W; Gerlag, D M; van Eck-Smit, B L F; Tak, P P

    2009-01-01

    Objective: To explore the effects of anti-tumour necrosis factor (TNF)α antibody therapy on bone mineral density (BMD) of the lumbar spine and femur neck in patients with rheumatoid arthritis (RA). Methods: A total of 50 patients with active RA (DAS28⩾3.2) who started adalimumab (40 mg subcutaneously/2 weeks) were included in an open label prospective study. All patients used stable methotrexate and were allowed to use prednisone (⩽10 mg/day). The BMD of the lumbar spine and femur neck was measured before and 1 year after start of treatment. Results: Disease activity at baseline (28-joint Disease Activity Score (DAS28)) and disease duration were inversely correlated with femoral neck BMD and lumbar spine BMD (p<0.05). Mean BMD of lumbar spine and femur neck remained unchanged after 1 year of adalimumab therapy (+0.3% and +0.3%, respectively). Of interest, a beneficial effect of prednisone on change in femur neck BMD was observed with a relative increase with prednisone use (+2.5%) compared to no concomitant prednisone use (−0.7%), (p = 0.015). Conclusion: In contrast to the progressive bone loss observed after conventional disease-modifying antirheumatic drug therapy, TNF blockade may result in an arrest of general bone loss. Consistent with previous observations, the data also suggest that the net effect of low-dose corticosteroids on BMD in RA may be beneficial, possibly resulting from their anti-inflammatory effects. PMID:18408246

  3. Trunk and hip muscle recruitment patterns during the prone leg extension following a lateral ankle sprain: A prospective case study pre and post injury

    Directory of Open Access Journals (Sweden)

    Lehman Gregory J

    2006-02-01

    Full Text Available Abstract Background and case presentation The prone leg extension (PLE is commonly used to identify dysfunction of muscle recruitment patterns. The prone leg extension is theorized to identify proximal muscle disturbances which are a result of distal injury or dysfunction (i.e. an ankle sprain. This case study compares the trunk and hip muscle (bilateral lower erector spine, ipsilateral hamstring and ipsilateral gluteus maximus timing during a PLE of a 27 year old female runner during a healthy state (pre ankle sprain and 2 and 8 weeks post ankle sprain. Results and discussion The gluteus maximus muscle onsets at 8 weeks post injury appeared to occur earlier compared with 2 weeks post injury. The Right Erector Spinae at 8 weeks post injury was also active earlier compared with the participant's non-injured state. A large degree of variability can be noted within trials on the same day for all muscle groups. Conclusion An acute ankle injury did not result in a delay in gluteus maximus muscle activation. The utility of the prone leg extension as a clinical and functional test is questionable due to the normal variability seen during the test and our current inability to determine what is normal and what is dysfunctional.

  4. Control of LDL-C in coronary heart disease patients within 1 year after coronary stenting:A multicenter follow-up study%冠状动脉支架置入术后1年内低密度脂蛋白胆固醇控制情况多中心随访研究

    Institute of Scientific and Technical Information of China (English)

    陈劲松; 邓节喜; 张丽伟; 田峰; 阮发晖; 陈韵岱

    2013-01-01

    Objective To provide the evidence for rational intervention of LDL-C by analyzing its control in coronary heart disease (CHD) patients after coronary stenting. Methods Baseline data before coronary stenting and 1-year follow-up data (including serum LDL-C level, drugs used, diet, exercises) about patients who underwent coronary stenting in 3 hospitals from January 2011 to June 2012 were analyzed.Results A total of 1 274 patients were followed up. The abnormal LDL-C rate was 30.0%, 36.3%, 44.8% respectively when its target value was set at 2.08 mmol/L and 45.7%, 53.4%, 58.6% respectively when its target value was set at 1.82 mmol/L 1, 6 and 12 months after coronary stenting (P<0.05). The incidence of major adverse cardiovascular events (MACEs) was significantly higher in patients with their LDL-C≥2.08 mmol/L 6 months after coronary stenting than in those 7 - 12 months after coronary stenting (7.5%vs 3.7%,P= 0.000 8). Multivariate logistic regression analysis revealed that non-adjusted lipid-decreasing statin therapy (OR = 2.73, 95%CI: 1.89 - 3.57), baseline LDL-C level≥3.37 mmol/L (OR = 2.28, 95%CI: 1.76 - 2.92), poor diet control (OR = 1.65, 95%CI: 1.21 - 2.37) and poor medication compliance (OR = 1.44, 95%CI: 1.09 - 2.15) were the risk factors for abnormal LDL-C.Conclusion LDL-C is abnormal in a considerable number of patients 1 year after coronary stenting. The incidence of MACEs is high in patients with abnormal LDL-C.%目的:分析患者冠状动脉支架置入术后1年内低密度脂蛋白胆固醇(low-density lipoprotein cholesterol,LDL-C)控制情况,为合理干预提供依据。方法收集三家医院于2011年1月-2012年6月接受冠状动脉支架置入术患者术前基线资料及1年随访资料,分析各项血脂指标的控制、用药、饮食及运动情况。结果随访患者共1274例,以2.08 mmol/L为LDL-C的目标值时,1个月、6个月、1年的未达标率分别为30.0%、36.3%、44.8%(P<0.05);以1.82 mmol

  5. Overstretching of a 30 bp DNA duplex studied with steered molecular dynamics simulation: Effects of structural defects on structure and force-extension relation

    Science.gov (United States)

    Li, H.; Gisler, T.

    2009-11-01

    Single-molecule experiments on polymeric DNA show that the molecule can be overstretched at nearly constant force by about 70% beyond its relaxed contour length. In this publication we use steered molecular dynamics (MD) simulation to study the effect of structural defects on force-extension curves and structures at high elongation in a 30 base pair duplex pulled by its torsionally unconstrained 5' -5' ends. The defect-free duplex shows a plateau in the force-extension curve at 120pN in which large segments with inclined and paired bases (“S-DNA”) near both ends of the duplex coexist with a central B-type segment separated from the former by small denaturation bubbles. In the presence of a base mismatch or a nick, force-extension curves are very similar to the ones of the defect-free duplex. For the duplex with a base mismatch, S-type segments with highly inclined base pairs are not observed; rather, the overstretched duplex consists of B-type segments separated by denaturation bubbles. The nicked duplex evolves, via a two-step transition, into a two-domain structure characterized by a large S-type segment coexisting with several short S-type segments which are separated by short denaturation bubbles. Our results suggest that in the presence of nicks the force-extension curve of highly elongated duplex DNA might reflect locally highly inhomogeneous stretching. Supplementary material in the form of a PDF file available from the Journal web page at 10.1140/epje/i2009-10524-5 and is accessible for authorised users.

  6. An Evaluation of the Mulligan Stew 4-H Television Series for Extension Service, USDA. Volume III: Case Studies.

    Science.gov (United States)

    Abt Associates, Inc., Cambridge, MA.

    Conducted on over 3,000 fourth, fifth, and sixth grade children in six states, this study documents changes in nutrition-related knowledge and behaviors which can be related to participating in the Mulligan Stew television series. The case studies which comprise this volume function as a brief organizational analysis of the Mulligan Stew effort at…

  7. Bottom pressure, vertical acoustic round-trip travel time, and near-bottom currents data collected by Current-and-Pressure-recording Inverted Echo Sounders (CPIES), as part of the Kuroshio Extension System Study (KESS), from 26 April 2004 to 25 June 2006 in the Kuroshio Extension east of Japan (NODC Accession 0073269)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set contains Current and Pressure recording Inverted Echo Sounder (CPIES) measurements collected during the Kuroshio Extension System Study (KESS) under...

  8. A simple risk stratification model that predicts 1-year postoperative mortality rate in patients with solid-organ cancer.

    Science.gov (United States)

    Chou, Wen-Chi; Wang, Frank; Cheng, Yu-Fan; Chen, Miao-Fen; Lu, Chang-Hsien; Wang, Cheng-Hsu; Lin, Yung-Chang; Yeh, Ta-Sen

    2015-11-01

    This study aimed to construct a scoring system developed exclusively from the preoperative data that predicts 1-year postoperative mortality in patients with solid cancers. A total of 20,632 patients who had a curative resection for solid-organ cancers between 2007 and 2012 at Chang Gung Memorial Hospital Linkou Medical Center were included in the derivation cohort. Multivariate logistic regression analysis was performed to develop a risk model that predicts 1-year postoperative mortality. Patients were then stratified into four risk groups (low-, intermediate-, high-, and very high-risk) according to the total score (0-43) form mortality risk analysis. An independent cohort of 16,656 patients who underwent curative cancer surgeries at three other hospitals during the same study period (validation cohort) was enrolled to verify the risk model. Age, gender, cancer site, history of previous cancer, tumor stage, Charlson comorbidity index, American Society of Anesthesiologist score, admission type, and Eastern Cooperative Oncology Group performance status were independently predictive of 1-year postoperative mortality. The 1-year postoperative mortality rates were 0.5%, 3.8%, 14.6%, and 33.8%, respectively, among the four risk groups in the derivation cohort (c-statistic, 0.80), compared with 0.9%, 4.2%, 14.6%, and 32.6%, respectively, in the validation cohort (c-statistic, 0.78). The risk stratification model also demonstrated good discrimination of long-term survival outcome of the four-tier risk groups (P model not only predicts 1-year postoperative mortality but also differentiates long-term survival outcome between the risk groups.

  9. Type A-B scores and insomnia among college students: a replication and extension of earlier studies.

    Science.gov (United States)

    Hayer, C A; Hicks, R A

    1993-12-01

    In an attempt to rationalize conflicting sets of data from earlier studies, groups of Type A- and Type B-classified university students were asked to respond to a sleep habits questionnaire that included the items of the Coren Insomnia Scale. As was the case in two earlier studies, we found significant but weak evidence from the Coren scale only that Type A-scoring students experience more sleep problems than Type B scorers. We also found, as in a recent study, a sharp increase in sleep problems among all the students sampled from the frequencies reported by similar groups in 1982.

  10. Strengthening the Reporting of Observational Studies in Epidemiology-Nutritional Epidemiology (STROBE-nut: An Extension of the STROBE Statement.

    Directory of Open Access Journals (Sweden)

    Carl Lachat

    2016-06-01

    Full Text Available Concerns have been raised about the quality of reporting in nutritional epidemiology. Research reporting guidelines such as the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE statement can improve quality of reporting in observational studies. Herein, we propose recommendations for reporting nutritional epidemiology and dietary assessment research by extending the STROBE statement into Strengthening the Reporting of Observational Studies in Epidemiology-Nutritional Epidemiology (STROBE-nut.Recommendations for the reporting of nutritional epidemiology and dietary assessment research were developed following a systematic and consultative process, coordinated by a multidisciplinary group of 21 experts. Consensus on reporting guidelines was reached through a three-round Delphi consultation process with 53 external experts. In total, 24 recommendations for nutritional epidemiology were added to the STROBE checklist.When used appropriately, reporting guidelines for nutritional epidemiology can contribute to improve reporting of observational studies with a focus on diet and health.

  11. Extensive Field Survey, Laboratory and Greenhouse Studies Reveal Complex Nature of Pseudomonas syringae-Associated Hazelnut Decline in Central Italy.

    Science.gov (United States)

    Lamichhane, Jay Ram; Bartoli, Claudia; Varvaro, Leonardo

    2016-01-01

    Pseudomonas avellanae (Pav) has been reported as the causal agent of bacterial decline and bacterial canker of hazelnut in Italy and Greece, respectively. Both hazelnut diseases were reported to be similar in terms of symptoms, severity and persistence. In this study, we found that both symptomatic and asymptomatic trees in the field were colonized by Pav. Multilocus Sequence Typing (MLST) analysis showed that Pav strains isolated during this study in Italy belong to the P. syringae phylogroup 1 and they are closely related to Pav strains previously isolated in Greece from hazelnut bacterial canker. On the other hand, strains isolated in earlier studies from hazelnut decline in Italy belong to both phylogroup 1 and 2 of P. syringae. Both phylogroup 1 strains of P. syringae from Greece and Italy are different than strains isolated in this study in terms of their capacity to excrete fluorescent pigments on different media. Despite the same plant genotype and cropping practices adopted, the incidence of hazelnut decline ranged from nearly 0 to 91% across our study sites. No disease developed on plants inoculated with Pav through wounding while leaf scar inoculations produced only mild disease symptoms. Based on our results and the previously reported correlation between pedo-climatic conditions and hazelnut decline, we conclude that hazelnut decline in central Italy could be incited by a combination of predisposing (adverse pedo-climatic conditions) and contributing factors (Pav). Because this is a true decline different from "bacterial canker" described in Greece, we refer to it as hazelnut decline (HD).

  12. Extension of Studies with 3M Empore TM and Selentec MAG *SEP SM Technologies for Improved Radionuclide Field Sampling

    Energy Technology Data Exchange (ETDEWEB)

    Beals, D.M. [Westinghouse Savannah River Company, AIKEN, SC (United States); Bibler, J.P.; Brooks, D.A.

    1996-07-10

    The Savannah River Technology Center is evaluating new field sampling methodologies to more easily determine concentrations of radionuclides in aqueous systems. One methodology studied makes use of 3M EmporeTM disks. The disks are composed of selective resins embedded in a Teflon support. The disks remove the ion of interest from aqueous solutions when the solution is passed through the disk. The disk can then be counted directly to quantify the isotope of interest. Four types of disks were studied during this work: for the extraction of technetium (two types), cesium, plutonium, and strontium. A sampler has been developed for automated, unattended, in situ use of the EmporeTM disks.

  13. Torque-wrench extension

    Science.gov (United States)

    Peterson, D. H.

    1981-01-01

    Torque-wrench extension makes it easy to install and remove fasteners that are beyond reach of typical wrenches or are located in narrow spaces that prevent full travel of wrench handle. At same time, tool reads applied torque accurately. Wrench drive system, for torques up to 125 inch-pounds, uses 2 standard drive-socket extensions in aluminum frame. Extensions are connected to bevel gear that turns another bevel gear. Gears produce 1:1 turn ratio through 90 degree translation of axis of rotation. Output bevel has short extension that is used to attach 1/4-inch drive socket.

  14. Type Safe Extensible Programming

    Science.gov (United States)

    Chae, Wonseok

    2009-10-01

    Software products evolve over time. Sometimes they evolve by adding new features, and sometimes by either fixing bugs or replacing outdated implementations with new ones. When software engineers fail to anticipate such evolution during development, they will eventually be forced to re-architect or re-build from scratch. Therefore, it has been common practice to prepare for changes so that software products are extensible over their lifetimes. However, making software extensible is challenging because it is difficult to anticipate successive changes and to provide adequate abstraction mechanisms over potential changes. Such extensibility mechanisms, furthermore, should not compromise any existing functionality during extension. Software engineers would benefit from a tool that provides a way to add extensions in a reliable way. It is natural to expect programming languages to serve this role. Extensible programming is one effort to address these issues. In this thesis, we present type safe extensible programming using the MLPolyR language. MLPolyR is an ML-like functional language whose type system provides type-safe extensibility mechanisms at several levels. After presenting the language, we will show how these extensibility mechanisms can be put to good use in the context of product line engineering. Product line engineering is an emerging software engineering paradigm that aims to manage variations, which originate from successive changes in software.

  15. Competency Modeling in Extension Education: Integrating an Academic Extension Education Model with an Extension Human Resource Management Model

    Science.gov (United States)

    Scheer, Scott D.; Cochran, Graham R.; Harder, Amy; Place, Nick T.

    2011-01-01

    The purpose of this study was to compare and contrast an academic extension education model with an Extension human resource management model. The academic model of 19 competencies was similar across the 22 competencies of the Extension human resource management model. There were seven unique competencies for the human resource management model.…

  16. Empirical Testing of a Theoretical Extension of the Technology Acceptance Model: An Exploratory Study of Educational Wikis

    Science.gov (United States)

    Liu, Xun

    2010-01-01

    This study extended the technology acceptance model and empirically tested the new model with wikis, a new type of educational technology. Based on social cognitive theory and the theory of planned behavior, three new variables, wiki self-efficacy, online posting anxiety, and perceived behavioral control, were added to the original technology…

  17. STrengthening the Reporting of OBservational studies in Epidemiology - Molecular Epidemiology (STROBE-ME): An extension of the STROBE statement

    NARCIS (Netherlands)

    Gallo, V.; Egger, M.; McCormack, V.; Farmer, P.B.; Ioannidis, J.P.; Kirsch-Volders, M.; Matullo, G.; Phillips, D.H.; Schoket, B.; Stromberg, U.; Vermeulen, R.; Wild, C.; Porta, M.; Vineis, P.

    2012-01-01

    Eur J Clin Invest 2012; 42 (1): 1-16 SUMMARY POINTS: Advances in laboratory techniques have led to a rapidly increasing use of biomarkers in epidemiological studies. Biomarkers of internal dose, early biological change, susceptibility and clinical outcomes are used as proxies for investigating inter

  18. STrengthening the Reporting of OBservational studies in Epidemiology - Molecular Epidemiology (STROBE-ME): An extension of the STROBE statement

    NARCIS (Netherlands)

    Gallo, V.; Egger, M.; McCormack, V.; Farmer, P.B.; Ioannidis, J.P.; Kirsch-Volders, M.; Matullo, G.; Phillips, D.H.; Schoket, B.; Stromberg, U.; Vermeulen, R.; Wild, C.; Porta, M.; Vineis, P.

    2012-01-01

    Advances in laboratory techniques have led to a rapidly increasing use of biomarkers in epidemiological studies. Biomarkers of internal dose, early biological change, susceptibility and clinical outcomes are used as proxies for investigating interactions between external and / or endogenous agents a

  19. STrengthening the Reporting of OBservational studies in Epidemiology - Molecular Epidemiology (STROBE-ME): An extension of the STROBE statement

    NARCIS (Netherlands)

    Gallo, V.; Egger, M.; McCormack, V.; Farmer, P.B.; Ioannidis, J.P.; Kirsch-Volders, M.; Matullo, G.; Phillips, D.H.; Schoket, B.; Stromberg, U.; Vermeulen, R.; Wild, C.; Porta, M.; Vineis, P.

    2012-01-01

    Advances in laboratory techniques have led to a rapidly increasing use of biomarkers in epidemiological studies. Biomarkers of internal dose, early biological change, susceptibility, and clinical outcomes are used as proxies for investigating the interactions between external and/or endogenous agent

  20. Novel models on fluid's variable thermo-physical properties for extensive study on convection heat and mass transfer

    Science.gov (United States)

    Shang, De-Yi; Zhong, Liang-Cai

    2016-04-01

    Our novel models for fluid's variable physical properties are improved and reported systematically in this work for enhancement of theoretical and practical value on study of convection heat and mass transfer. It consists of three models, namely (1) temperature parameter model, (2) polynomial model, and (3) weighted-sum model, respectively for treatment of temperature-dependent physical properties of gases, temperature-dependent physical properties of liquids, and concentration- and temperature-dependent physical properties of vapour-gas mixture. Two related components are proposed, and involved in each model for fluid's variable physical properties. They are basic physic property equations and theoretical similarity equations on physical property factors. The former, as the foundation of the latter, is based on the typical experimental data and physical analysis. The latter is built up by similarity analysis and mathematical derivation based on the former basic physical properties equations. These models are available for smooth simulation and treatment of fluid's variable physical properties for assurance of theoretical and practical value of study on convection of heat and mass transfer. Especially, so far, there has been lack of available study on heat and mass transfer of film condensation convection of vapour-gas mixture, and the wrong heat transfer results existed in widespread studies on the related research topics, due to ignorance of proper consideration of the concentration- and temperature-dependent physical properties of vapour-gas mixture. For resolving such difficult issues, the present novel physical property models have their special advantages.

  1. Explanation and Elaboration Document for the STROBE-Vet Statement: Strengthening the Reporting of Observational Studies in Epidemiology - Veterinary Extension

    DEFF Research Database (Denmark)

    O'Connor, A M; Sargeant, J M; Dohoo, I R;

    2016-01-01

    The STROBE (Strengthening the Reporting of Observational Studies in Epidemiology) statement was first published in 2007 and again in 2014. The purpose of the original STROBE was to provide guidance for authors, reviewers and editors to improve the comprehensiveness of reporting; however, STROBE h...

  2. Novel models on fluid's variable thermo-physical properties for extensive study on convection heat and mass transfer

    Science.gov (United States)

    Shang, De-Yi; Zhong, Liang-Cai

    2017-01-01

    Our novel models for fluid's variable physical properties are improved and reported systematically in this work for enhancement of theoretical and practical value on study of convection heat and mass transfer. It consists of three models, namely (1) temperature parameter model, (2) polynomial model, and (3) weighted-sum model, respectively for treatment of temperature-dependent physical properties of gases, temperature-dependent physical properties of liquids, and concentration- and temperature-dependent physical properties of vapour-gas mixture. Two related components are proposed, and involved in each model for fluid's variable physical properties. They are basic physic property equations and theoretical similarity equations on physical property factors. The former, as the foundation of the latter, is based on the typical experimental data and physical analysis. The latter is built up by similarity analysis and mathematical derivation based on the former basic physical properties equations. These models are available for smooth simulation and treatment of fluid's variable physical properties for assurance of theoretical and practical value of study on convection of heat and mass transfer. Especially, so far, there has been lack of available study on heat and mass transfer of film condensation convection of vapour-gas mixture, and the wrong heat transfer results existed in widespread studies on the related research topics, due to ignorance of proper consideration of the concentration- and temperature-dependent physical properties of vapour-gas mixture. For resolving such difficult issues, the present novel physical property models have their special advantages.

  3. Extensive Field Survey, Laboratory and Greenhouse Studies Reveal Complex Nature of Pseudomonas syringae-Associated Hazelnut Decline in Central Italy.

    Directory of Open Access Journals (Sweden)

    Jay Ram Lamichhane

    Full Text Available Pseudomonas avellanae (Pav has been reported as the causal agent of bacterial decline and bacterial canker of hazelnut in Italy and Greece, respectively. Both hazelnut diseases were reported to be similar in terms of symptoms, severity and persistence. In this study, we found that both symptomatic and asymptomatic trees in the field were colonized by Pav. Multilocus Sequence Typing (MLST analysis showed that Pav strains isolated during this study in Italy belong to the P. syringae phylogroup 1 and they are closely related to Pav strains previously isolated in Greece from hazelnut bacterial canker. On the other hand, strains isolated in earlier studies from hazelnut decline in Italy belong to both phylogroup 1 and 2 of P. syringae. Both phylogroup 1 strains of P. syringae from Greece and Italy are different than strains isolated in this study in terms of their capacity to excrete fluorescent pigments on different media. Despite the same plant genotype and cropping practices adopted, the incidence of hazelnut decline ranged from nearly 0 to 91% across our study sites. No disease developed on plants inoculated with Pav through wounding while leaf scar inoculations produced only mild disease symptoms. Based on our results and the previously reported correlation between pedo-climatic conditions and hazelnut decline, we conclude that hazelnut decline in central Italy could be incited by a combination of predisposing (adverse pedo-climatic conditions and contributing factors (Pav. Because this is a true decline different from "bacterial canker" described in Greece, we refer to it as hazelnut decline (HD.

  4. [The combined DAK therapy of obesity for children and adolescents. Evaluation after 1 year].

    Science.gov (United States)

    Adam, S; Westenhöfer, J; Rudolphi, B; Kraaibeek, H K

    2008-04-10

    In 2003, the program "The combined DAK therapy of obesity for children and adolescents", funded and conducted by the Deutsche Angestellten Krankenkasse (DAK) (A German Health Insurance Company), has started. The whole treatment lasts for 1 year including an initial inpatient therapy for 6 weeks followed by an outpatient treatment at home that adresses the overweight patients and their families. The therapy contents are developed according to the recommendations of the "Arbeitsgemeinschaft Adipositas im Kindes- und Jugendalter (AGA)". In a prospective cohort study a sample of 604 subjects was studied in order to examine the achievement of the treatment goals weight reduction, behaviour modification and improvement of quality of life. The development of weight was evaluated using BMI-SDS. 44,1% of children and adolescents had a successful weight reduction, they reduced their weight at least by 0,3 BMI-SDS. Furthermore, significant changes of health behaviour, physical fitness and quality of life were observed. However, during the outpatient treatment an impairment of some behaviour changes were observed. Nevertheless, the study has identified significant, positive effects in weight loss, behaviour modifications, changes in physical fitness and in the development of quality of life as a result of the therapy. It is demonstrated that a relapse in "old behaviour" followed by an increase of weight after the inpatient treatment can be avoided bythe subsequent outpatient therapy.

  5. Effectiveness of sealing active proximal caries lesions with an adhesive system: 1-year clinical evaluation

    Directory of Open Access Journals (Sweden)

    Clarisse Abuchaim

    2010-09-01

    Full Text Available The objective of this study was to evaluate the effectiveness of a therapeutic sealant to arrest non-cavitated proximal carious lesion progression. The study population comprised 44 adolescents who had bitewing radiographs taken for caries diagnosis. Non-cavitated lesions extending up to half of dentin thickness were included in the sample. In the experimental group (n = 33, the proximal caries-lesion surfaces were sealed with an adhesive (OptiBond Solo, Kerr after tooth separation. The control group (n = 11 received no treatment, except for oral hygiene instructions including use of dental floss. Follow-up radiographs were taken after one year and were analyzed in comparison with baseline radiographs. In a blind study setting, visual readings were performed by two examiners, blinded to whether the examined radiograph was baseline or follow-up, and whether it concerned a test or control lesion. The efficacy of sealing treatment was evaluated by the McNemar test (0.05. About 22% of the sealed lesions showed reduction, 61% showed no change and 16% showed progression. For the control lesions, the corresponding values were 27%, 36% and 36% respectively. The number of lesions that showed reduction and no changes were merged and therefore 83.3% of the sealed lesions and 63.6% of the control lesions were considered clinically successful. No statistical significance was detected (p > 0.05. In the course of 1 year, sealing proximal caries lesions was not shown to be superior to lesion monitoring.

  6. Dissociated incretin response to oral glucose at 1 year after restrictive vs. malabsorptive bariatric surgery

    DEFF Research Database (Denmark)

    Guldstrand, M; Ahrén, B; Näslund, E;

    2009-01-01

    (JIB, n = 5) was performed in 12 women, aged 26-39 years, with severe obesity [body mass index (BMI) 46.6 +/- 2.3 kg/m(2)]. After 1 year, 75 g glucose was administered and plasma levels of glucose, insulin, GIP and GLP-1 were determined regularly during the following 2 h. RESULTS: At 1 year after......AIM: Compare the response to oral glucose of the two incretin hormones, glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) at 1 year after restrictive vs. malabsorptive bariatric surgery. METHODS: Vertical banded gastroplasty (VBG, n = 7) or jejunoileal bypass...... = 0.007). CONCLUSIONS: We conclude that at 1 year after bariatric surgery, the two incretins show dissociated responses in that the GIP secretion is higher after VBG whereas GLP-1 secretion is higher after JIB. This dissociated incretin response is independent from reduction in body weight, glucose...

  7. Automation impact study of Army training management 2: Extension of sampling and collection of installation resource data

    Energy Technology Data Exchange (ETDEWEB)

    Sanquist, T.F.; McCallum, M.C.; Hunt, P.S.; Slavich, A.L.; Underwood, J.A.; Toquam, J.L.; Seaver, D.A.

    1989-05-01

    This automation impact study of Army training management (TM) was performed for the Army Development and Employment Agency (ADEA) and the Combined Arms Training Activity (CATA) by the Battelle Human Affairs Research Centers and the Pacific Northwest Laboratory. The primary objective of the study was to provide the Army with information concerning the potential costs and savings associated with automating the TM process. This study expands the sample of units surveyed in Phase I of the automation impact effort (Sanquist et al., 1988), and presents data concerning installation resource management in relation to TM. The structured interview employed in Phase I was adapted to a self-administered survey. The data collected were compatible with that of Phase I, and both were combined for analysis. Three US sites, one reserve division, one National Guard division, and one unit in the active component outside the continental US (OCONUS) (referred to in this report as forward deployed) were surveyed. The total sample size was 459, of which 337 respondents contributed the most detailed data. 20 figs., 62 tabs.

  8. Homology models of human gamma-crystallins: structural study of the extensive charge network in gamma-crystallins.

    Science.gov (United States)

    Salim, Asmat; Zaidi, Zafar H

    2003-01-17

    The lens is composed of highly stable and long-lived proteins, the crystallins which are divided into alpha-, beta-, and gamma-crystallins. Human gamma-crystallins belong to the betagamma superfamily. A large number of gamma-crystallins have been sequenced and have been found to share remarkable sequence homology with each other. Some of the gamma-crystallins from various sources have also been elucidated structurally by X-ray crystallographic or NMR spectroscopic experiments. Their three-dimensional structures are also similar having consisted of two domains each possessing two Greek key motifs. In this study we have constructed the comparative or homology models of the four major human gamma-crystallins, gammaA-,gammaB-, gammaC-, and gammaD-crystallins and studied the charge network in these crystallins. Despite an overall structural similarity between these crystallins, differences in the ion pair formation do exist which is partly due to the differences in their primary sequence and partly due to the structural orientation of the neighboring amino acids. In this study, we present an elaborate analysis of these charged interactions and their formation or loss with respect to the structural changes.

  9. The bilateral leg strength deficit is present in old, young and adolescent females during isokinetic knee extension and flexion.

    Science.gov (United States)

    Kuruganti, Usha; Seaman, Kenneth

    2006-06-01

    The bilateral limb deficit (BLD) describes the difference in maximal or near maximal force generating capacity of muscles when they are contracted alone or in combination with the contralateral muscles. A deficit occurs when the summed unilateral force is greater than the bilateral force. This study examined the presence of the BLD during isokinetic knee extensions and flexions in a group of adolescent females (n=8, mean of 15+/-1 years) and compared with previously reported data by this researcher of adult and older females. Data were collected from subjects during slow (45 deg/s) isokinetic knee extensions and flexions and it was found that a BLD exists during both extension and flexion regardless of age. Furthermore, this study is the first to examine the presence of the deficit in an adolescent population. Myoelectric signal (MES) data showed that there is no difference between bilateral and unilateral isokinetic knee extensions and flexions regardless of age group.

  10. Studies of an extensively axisymmetric rocket based combined cycle (RBCC) engine powered single-stage-to-orbit (SSTO) vehicle

    Science.gov (United States)

    Foster, Richard W.; Escher, William J. D.; Robinson, John W.

    1989-01-01

    The present comparative performance study has established that rocket-based combined cycle (RBCC) propulsion systems, when incorporated by essentially axisymmetric SSTO launch vehicle configurations whose conical forebody maximizes both capture-area ratio and total capture area, are capable of furnishing payload-delivery capabilities superior to those of most multistage, all-rocket launchers. Airbreathing thrust augmentation in the rocket-ejector mode of an RBCC powerplant is noted to make a major contribution to final payload capability, by comparison to nonair-augmented rocket engine propulsion systems.

  11. A human breast cancer model for the study of telomerase inhibitors based on a new biotinylated-primer extension assay

    OpenAIRE

    1999-01-01

    Telomerase is an RNA-dependent polymerase that synthesizes telomeric DNA (TTAGGG)n repeats. The overall goal of our work was to establish human cancer models that can be used to design clinical trials with telomerase inhibitors. The objectives of this study were (1) to set up a human breast cancer system that allows evaluation of the effects of telomerase inhibitors in cultured cells using a non-amplified telomerase assay and (2) to test this system using two drugs (cisplatin and TMPyP4) that...

  12. An extensive optical study of V2491 Cyg (Nova Cyg 2008 N.2), from maximum brightness to return to quiescence

    CERN Document Server

    Munari, U; Dallaporta, S; Cherini, G; Valisa, P; Tomasella, L

    2010-01-01

    The photometric and spectroscopic evolution of the He/N and very fast Nova Cyg 2008 N2 (V2491 Cyg) is studied in detail. A primary maximum was reached at V=7.45 +/-0.05 on April 11.37 (+/-0.1) 2008 UT, followed by a smooth decline characterized by t2(V)=4.8 days, and then a second maximum was attained at V=9.49 +/-0.03, 14.5 days after the primary one. This is the only third nova to have displayed a secondary maximum, after V2362 Cyg and V1493 Aql. The development and energetics of the secondary maximum is studied in detail. The smooth decline that followed was accurately monitored until day +144 when the nova was 8.6 mag fainter than maximum brightness, well into its nebular phase, with its line and continuum emissivity declining as t-3. The reddening affecting the nova was E(B-V)=0.23 +/-0.01, and the distance of 14 kpc places the nova at a height above the galactic plane of 1.1 kpc, larger than typical for He/N novae. The expansion velocity of the bulk of ejecta was 2000 km/sec, with complex emission profi...

  13. Overview of an Extensive Multi-wavelength Study of GX 339-4 during the 2010 Outburst

    CERN Document Server

    Bel, M Cadolle; D'Avanzo, P; Russell, D M; Tomsick, J; Corbel, S; Lewis, F; Rahoui, F; Buxton, M; Goldoni, P; Kuulkers, E

    2011-01-01

    The microquasar GX 339-4 experienced a new outburst in 2010: it was observed simultaneously at various wavelengths from radio up to soft gamma-rays. We focused on observations that are quasi-simultaneous with those made with the INTEGRAL and RXTE satellites: these were collected in 2010 March-April during our INTEGRAL Target of Opportunity program, and during some of the other INTEGRAL observing programs with GX 339-4 in the field-of-view. X-ray transients are extreme systems that often harbour a black hole, and are known to emit throughout the whole electromagnetic spectrum when in outburst. The goals of our program are to understand the evolution of the physical processes close to the black hole and to study the connections between the accretion and ejection. We analysed radio, NIR, optical, UV, X-ray and soft gamma-ray observations. We studied the source evolution in detail by producing light curves, hardness-intensity diagrams and spectra. We fitted the broadband data with phenomenological, then physical,...

  14. Matrix Extension Study: Validation of the Compact Dry CF Method for Enumeration of Total Coliform Bacteria in Selected Foods.

    Science.gov (United States)

    Mizuochi, Shingo; Nelson, Maria; Baylis, Chris; Green, Becky; Jewell, Keith; Monadjemi, Farinaz; Chen, Yi; Salfinger, Yvonne; Fernandez, Maria Cristina

    2016-01-01

    The Compact Dry "Nissui" CF method, Performance Tested Method(SM) 110401, was originally certified for enumeration of coliform bacteria by the AOAC Research Institute Performance Tested Methods(SM) program for raw meat products. Compact Dry CF is a ready-to-use dry media sheet, containing a cold-soluble gelling agent, a chromogenic medium, and selective agents, which are rehydrated by adding 1 mL of diluted sample. Coliform bacteria produce blue/blue-green colonies on the Compact Dry CF, allowing a coliform colony count to be determined in the sample after 24 ± 2 h incubation. A validation study was organized by Campden BRI (formerly Campden and Chorleywood Food Research Association Technology, Ltd), Chipping Campden, United Kingdom, to extend the method's claim to include cooked chicken, fresh bagged prewashed shredded iceberg lettuce, frozen fish, milk powder, and pasteurized 2% milk. Campden BRI collected single-laboratory data for cooked chicken, lettuce, frozen fish, and milk powder, whereas a multilaboratory study was conducted on pasteurized milk. Thirteen laboratories participated in the interlaboratory study. The Compact Dry CF method was compared to ISO 4832:2006 "Microbiology of food and animal feeding stuffs-Horizontal method for the enumeration of coliforms-Colony-count technique," the current version at the time this study was conducted. Each matrix was evaluated at either four or five contamination levels of coliform bacteria (including an uncontaminated level). After logarithmic transformation of counts at each level, the data for pasteurized whole milk were analyzed for sr, sR, RSDr, and RSDR. Regression analysis was also performed and r(2) was reported. Mean difference between methods with 95% confidence interval (CI) was calculated. A log10 range of -0.5 to 0.5 for the CI was used as the acceptance criterion to establish significant statistical difference between methods. In the single-laboratory evaluation (for cooked chicken, lettuce, frozen

  15. Inductions and coinductions for Hopf extensions

    Institute of Scientific and Technical Information of China (English)

    Freddy Van Oystaeyen; 许永华; 张印火

    1996-01-01

    The induction and coinduction functors for the two types of Hopf extensions (Hopf Galois extensions and dual to Hopf Galois extension) and the symmetry between them are studied; by using the theory of separable functors further links between these two classes are provided.

  16. Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study

    Directory of Open Access Journals (Sweden)

    Cribbs David H

    2012-07-01

    Full Text Available Abstract Background This study undertakes a systematic and comprehensive analysis of brain gene expression profiles of immune/inflammation-related genes in aging and Alzheimer’s disease (AD. Methods In a well-powered microarray study of young (20 to 59 years, aged (60 to 99 years, and AD (74 to 95 years cases, gene responses were assessed in the hippocampus, entorhinal cortex, superior frontal gyrus, and post-central gyrus. Results Several novel concepts emerge. First, immune/inflammation-related genes showed major changes in gene expression over the course of cognitively normal aging, with the extent of gene response far greater in aging than in AD. Of the 759 immune-related probesets interrogated on the microarray, approximately 40% were significantly altered in the SFG, PCG and HC with increasing age, with the majority upregulated (64 to 86%. In contrast, far fewer immune/inflammation genes were significantly changed in the transition to AD (approximately 6% of immune-related probesets, with gene responses primarily restricted to the SFG and HC. Second, relatively few significant changes in immune/inflammation genes were detected in the EC either in aging or AD, although many genes in the EC showed similar trends in responses as in the other brain regions. Third, immune/inflammation genes undergo gender-specific patterns of response in aging and AD, with the most pronounced differences emerging in aging. Finally, there was widespread upregulation of genes reflecting activation of microglia and perivascular macrophages in the aging brain, coupled with a downregulation of select factors (TOLLIP, fractalkine that when present curtail microglial/macrophage activation. Notably, essentially all pathways of the innate immune system were upregulated in aging, including numerous complement components, genes involved in toll-like receptor signaling and inflammasome signaling, as well as genes coding for immunoglobulin (Fc receptors and human

  17. Evidence of Rapidly Warming Rivers in the UK from an Extensive Additive Modelling Study at the National Scale Using R

    Science.gov (United States)

    Simpson, G. L.

    2011-12-01

    River water temperature data exhibit non-linear behaviour over the past 50 or so years. Standard techniques for identifying and quantifying trends have centred around the use of linear regression and Mann-Kendall and Thiel-Sen procedures. Observational data from UK rivers suggest that temperatures are far more variable then assumed under these statistical models. In a national-scale assessment of the response of riverine systems to global climatic change, an additive model framework was employed to model patterns in water temperatures from a large database of temporal observational data. Models were developed using R, which allowed for the deployment of cutting-edge additive modelling techniques to describe trends at 2773 sites across England and Wales, UK. At a subset of sites, additive models were used to model long-term trends, trends within seasons and the long-term variation in the seasonal pattern of water temperatures. Changes in water temperature have important consequences for aquatic ecology, with some species being particularly sensitive even to small shifts in temperature during some or all of their lifecycle. While there are many studies reporting increasing regional and global air temperatures, evidence for changes in river water temperature has thus far been site specific and/or from sites heavily influenced by human activities that could themselves lead to warming. Here I present selected results from a national-scale assessment of changing river water temperatures, covering the whole of England and Wales, comprising data from 2,773 locations. Positive trends in water temperature were observed at 86% of sites. At a subset of sites, seasonal trend models were developed, which showed that 90% of locations demonstrated statistically significant increases in water temperature during Autumn and Winter periods. Multivariate smoothers, that allow for within-year and longer-term trend interactions in time, suggest that periods of warmer waters now extend

  18. Fish Culture Economics and Extension

    Directory of Open Access Journals (Sweden)

    E.N. Ogamba

    2012-12-01

    Full Text Available Fish culture economics and extension was reviewed to enable fish culturist plan effectively before involved in fish culture and practices. The cost and benefits of fish culture need be known before participation in the business. There is need for cross-link between research and the fishing community. Prior to introduction of any new innovation in fisheries extension and evaluation of such programmers, the agency responsible for such exercise should have full knowledge of the existing farming practice/techniques and the reasons behind them. In assessing or evaluating the impact of any new techniques or programmers, consideration should be given to such factors as natural conditions, local infrastructures, socio cultural setting, farmers’ production aims and labor economics. The study reviews the types of feasibility study, a typical feasibility study and report on a fish farm project and detail analysis of culture extension to enable fish culturist plan effectively before involved in fish culture and practices.

  19. Do Multidimensional Pain Inventory scale score changes indicate risk of receiving sick leave benefits 1 year after a pain rehabilitation programme?

    DEFF Research Database (Denmark)

    Nyberg, Vanja E; Novo, Mehmed; Sjölund, Bengt H

    2011-01-01

    To study whether scale score changes in the Multidimensional Pain Inventory (MPI) can predict which persons disabled by pain will receive sick leave benefits 1 year after completing a pain rehabilitation programme.......To study whether scale score changes in the Multidimensional Pain Inventory (MPI) can predict which persons disabled by pain will receive sick leave benefits 1 year after completing a pain rehabilitation programme....

  20. Gain in Quality-adjusted Life-years in Patients with Rheumatoid Arthritis During 1 Year of Biological Therapy

    DEFF Research Database (Denmark)

    Linde, Louise; Sørensen, Jan; Østergaard, Mikkel;

    2013-01-01

    The quality-adjusted life-year (QALY) is used to measure outcome in rheumatoid arthritis (RA) studies; identification of drivers of a gain in QALY might help predict a treatment response. We investigated how changes in components of the Disease Activity Score-28 joints (DAS28) were associated...... with the European League Against Rheumatism (EULAR) and European Quality of Life 5 Dimensions (EQ-5D) responses; and what baseline variables predicted the change in QALY following 1 year of biological therapy....

  1. Experience with cinacalcet in primary hyperparathyroidism: results after 1 year of treatment

    Science.gov (United States)

    García-Martín, Antonia; Luque-Pazos, Alessandra

    2013-01-01

    Objectives: To assess the characteristics of patients with primary hyperparathyroidism (PHPT) treated with cinacalcet and to evaluate its efficacy in reducing serum calcium and parathyroid hormone (PTH) concentrations after 1 year of treatment. Methods: The study included 20 patients with PHPT who had completed at least 12 months of treatment with cinacalcet (eight patients for refusal of parathyroidectomy, three for surgery not possible due to comorbidities and nine for progressive hypercalcemia prior to surgery). We recorded clinical and biochemical data at baseline, and after 3, 6 and 12 months of treatment. We also monitored adverse events. Cinacalcet was administered in increasing doses until normal serum calcium was reached or side effects preventing a further increase occurred. Results: After 3 months of treatment, serum calcium significantly decreased (11.73 ± 0.85 versus 10.71 ± 1.63 mg/dl, p < 0.001) and serum phosphorus significantly increased (2.41 ± 0.48 versus 2.63 ± 0.70 mg/dl, p = 0.004) while no significant change occurred in PTH (181.91 ± 102.37 versus 195.47 ± 111.71 pg/ml, p = 0.695). No further variation was observed after 6 months compared with 3 months of follow up. However, after 12 months of treatment, there was a significant decrease in PTH concentrations compared with baseline (181.91 ± 102.37 versus 152.47± 70.16 pg/ml, p = 0.028) as well as serum calcium (11.73 ± 0.85 versus 10.20± 0.95 mg/dl, p < 0.001); serum phosphorus significantly increased (2.41 ± 0.48 versus 2.71 ± 0.43 mg/dl, p = 0.01). Normocalcemia (S-Ca < 10.2 mg/dl) was achieved in 55% of patients. The medication was usually well tolerated (83.4%). Most common adverse events were nausea and vomiting, especially at the beginning of therapy. Conclusion: Cinacalcet rapidly reduced serum calcium in patients with PHPT and this reduction remained stable after 1 year of treatment. We also observed a decrease in PTH. Cinacalcet is an effective alternative in nonsurgical

  2. A 1-year clinical evaluation of fissure sealants on permanent first molars

    Directory of Open Access Journals (Sweden)

    Nupur Ninawe

    2012-01-01

    Full Text Available Objective : To evaluate and compare the retention, marginal discoloration, surface texture and anatomical form of pit and fissure sealants. Materials and Methods : Thirty children between the ages of 6 and 10 years, who were attending the school health program regularly, had participated in the study. A split-mouth design was used in which the two fissure sealants (Helioseal-F and Glass ionomer Fuji VII were randomly placed in 60 matched contralateral pairs of permanent molar teeth. Sealants were rated by a single trained and calibrated examiner using mouth mirrors and probes following the US Public Health Service criteria. The sealants were evaluated at 3 months, 6 months and 1 year intervals. Results : The data obtained for retention, marginal discoloration, surface texture and anatomical form of pit and fissure sealants were tabulated and compared statistically using the Chi-square test of significance. Conclusion : The Helioseal-F sealant was better than the Glass ionomer Fuji VII sealant with respect to retention, anatomical form and surface texture. Both the materials showed similar results with respect to marginal discoloration.

  3. Mandibular incisor alignment and dental arch changes 1 year after extraction of deciduous canines.

    Science.gov (United States)

    Sjögren, Anders; Arnrup, Kristina; Lennartsson, Bertil; Huggare, Jan

    2012-10-01

    This study investigated the early effects on mandibular incisor irregularity and rotation together with dental arch dimensions of the extraction of four deciduous canines. Children, during early mixed dentition, were randomized into one extraction (n = 32) and one control (n = 41) group. Dental casts from baseline (T0) and 1 year follow-up (T1) were used to evaluate changes in the irregularity index and in mandibular incisor rotation, dental arch dimensions, overjet, and overbite. Median mandibular incisor irregularity decreased over time, significantly more in the extraction than the control group (1.2 versus 0.7 mm; P extraction group (42 versus 20 per cent; P extraction group versus 34 per cent in the control group (P extraction group (1.3, 1.1 mm and 2.4, 2.0 mm, respectively; P extraction of the deciduous canines, small improvements in mandibular incisor alignment were seen, together with reduced arch dimensions. Little's index underestimated malalignment related to tooth rotation.

  4. The First Cause of Traumatic Death in Children < 1 Year: A Review on Abusive Head Trauma

    Directory of Open Access Journals (Sweden)

    Pietro Ferrara

    2016-07-01

    Full Text Available Context Pediatric abusive head trauma (AHT can be defined as an injury to the skull or intracranial contents of a child under the age of 5 due to inflicted blunt impact or violent shaking. Evidence Acquisition AHT is the most common cause of traumatic death in children younger than 1 year, and it is the leading cause of death due to child abuse. Clinical presentation observed in children with AHT depends on the type of AHT and accompanying injuries. History and physical examination are important for diagnosing AHT and for distinguishing it from other conditions that can mimic shaken baby syndrome, such as accidental trauma, cancer, metabolic diseases, and others. Results Progress in research on the medical diagnosis of AHT has been remarkable, while the development of treatment strategies has been limited. For these reasons, there is an urgent need to develop effective treatment strategies for AHT able to improve the outcomes. Conclusions The construction of a nationwide database that supports clinical studies is required in the future.

  5. Predictors of mortality within 1 year after primary ovarian cancer surgery

    DEFF Research Database (Denmark)

    Ørskov, Mette; Iachina, Maria; Guldberg, Rikke;

    2016-01-01

    important predictors of mortality from the multivariable model were residual tumour tissue >2 cm versus no residual tumour (HR=4.58 (95% CI 3.20 to 6.59)), residual tumour tissue ≤2 cm versus no residual tumour (HR=2.50 (95% CI 1.63 to 3.82)) and age >64 years versus age ≤64 years (HR=2.33 (95% CI 1.69 to 3......OBJECTIVES: To identify predictors of mortality within 1 year after primary surgery for ovarian cancer. DESIGN: Prospective nationwide cohort study from 1 January 2005 to 31 December 2012. SETTING: Evaluation of data from the Danish Gynaecology Cancer Database and the Danish Civil Registration...... (ASA) score, body mass index (BMI), International Federation of Gynaecology and Obstetrics (FIGO) stage, residual tumour tissue after surgery, perioperative blood transfusion and calendar year of surgery. RESULTS: The overall 1-year survival was 84%. Within 0-180 days after surgery, the 3 most...

  6. [Factors associated with the psychological impact of the Great East Japan earthquake on high school students 1 year and 4 months after the disaster].

    Science.gov (United States)

    Funakoshi, Shunichi; Ohno, Takashi; Kodaka, Akira; Okuyama, Junko; Honda, Nami; Inoue, Takao; Sato, Yuki; Miyajima, Maki; Tomita, Hiroaki; Denda, Kenzou; Matsuoka, Hiroo

    2014-01-01

    The purpose of this study was to investigate factors associated with the psychological impact of the Great East Japan Earthquake on high school students 1 year and 4 months after the disaster, and clarify support needs of the students. In the outreach program for students of three high schools in coastal areas of southern Miyagi Prefecture, Japan, 1,973 students were surveyed after obtaining informed consent for participation. Questionnaires included: the Quick Inventory of Depressive Symptomatology (QIDS-J), Self-rating Anxiety Scale (SAS), Impact of Event Scale-revised (IES-R), and Connor-Davidson Resilience Scale (CD-RISC10). All scores were compared using SPSS 20.0 J between school grades, locations of the schools, and extent of damage due to the Great East Japan Earthquake. Our analysis showed a significant positive correlation between school grades and the level of anxiety. PTSR scores, but not anxiety nor depressive scores, of students whose lives have suffered extensive damage were significantly higher than those of students who have not. Students of high schools which have suffered extensive damage and use temporary buildings showed significantly higher levels of depression and anxiety, and significantly lower resilience, compared to students of high schools which were not damaged. Although previous findings demonstrated that younger children have a higher risk of being influenced by disasters, symptoms related to PTSR and depression were found frequently in the high school students as well. Among the high school students, our analysis showed a positive correlation between the level of anxiety and school grades, probably because the disaster has affected an influential and pivotal point in their lives.

  7. Benefits of extensive recruitment effort persist during follow-ups and are consistent across age group and survey method. The TRAILS study

    Directory of Open Access Journals (Sweden)

    Nederhof Esther

    2012-07-01

    Full Text Available Abstract Background Extensive recruitment effort at baseline increases representativeness of study populations by decreasing non-response and associated bias. First, it is not known to what extent increased attrition occurs during subsequent measurement waves among subjects who were hard-to-recruit at baseline and what characteristics the hard-to-recruit dropouts have compared to the hard-to-recruit retainers. Second, it is unknown whether characteristics of hard-to-recruit responders in a prospective population based cohort study are similar across age group and survey method. Methods First, we compared first wave (T1 easy-to-recruit with hard-to-recruit responders of the TRacking Adolescents’ Individual Lives Survey (TRAILS, a prospective population based cohort study of Dutch (preadolescents (at first wave: n = 2230, mean age = 11.09 (SD 0.56, 50.8% girls, with regard to response rates at subsequent measurement waves. Second, easy-to-recruit and hard-to-recruit participants at the fourth TRAILS measurement wave (n = 1881, mean age = 19.1 (SD 0.60, 52.3% girls were compared with fourth wave non-responders and earlier stage drop-outs on family composition, socioeconomic position (SEP, intelligence (IQ, education, sociometric status, substance use, and psychopathology. Results First, over 60% of the hard-to-recruit responders at the first wave were retained in the sample eight years later at the fourth measurement wave. Hard-to-recruit dropouts did not differ from hard-to-recruit retainers. Second, extensive recruitment efforts for the web based survey convinced a population of nineteen year olds with similar characteristics as the hard-to-recruit eleven year olds that were persuaded to participate in a school-based survey. Some characteristics associated with being hard-to-recruit (as compared to being easy-to-recruit were more pronounced among non-responders, resembling the baseline situation (De Winter et al.2005

  8. Prevalence of anal incontinence during pregnancy and 1 year after delivery in a cohort of primiparous women and a control group of nulliparous women

    DEFF Research Database (Denmark)

    Svare, Jens A; Hansen, Bent B; Lose, Gunnar

    2016-01-01

    INTRODUCTION: The aim of the study was to examine the prevalence of anal incontinence (AI) during pregnancy and 1 year after delivery in primiparous women and to compare it with the prevalences in nulliparous women. MATERIAL AND METHODS: A validated questionnaire regarding AI was filled in by 1018...... primiparous women after delivery and by 1836 nulliparous women (baseline). A similar questionnaire was filled in 1 year later by both groups. RESULTS: At baseline the prevalence of flatus incontinence was significantly higher in the primiparous than the nulliparous women (35 vs. 25%), while incontinence...... study showed remarkably high prevalences of AI during pregnancy and 1 year after delivery in primiparous women and likewise in nulliparous women at baseline and 1 year later. These results may indicate that factors other than pregnancy and delivery are of importance for AI in young women....

  9. Cotorsion Pair Extensions

    Institute of Scientific and Technical Information of China (English)

    De Xu ZHOU

    2009-01-01

    Assume that S is an almost excellent extension of R. Using functors Hom R(S,-) and -(×)R S, we establish some connections between classes of modules (L)R and (L)S, cotorsion pairs ((A)R, (A)R)and ((A)S, (B)S). If (L)S is a T-extension or (and) H-extension of (L)R, we show that (L)S is a (resp., monomorphic, epimorphic, special) preenveloping class if and only if so is (L)R. If (S, S) is a TH-extension of ((A)R,(B)R), we obtain that ((A)S,(B)S) is complete (resp., of finite type, of cofinite type, hereditary, perfect, n-tilting) if and only if so is ((A)R,(B)R).

  10. University of Wisconsin - Extension

    Science.gov (United States)

    ... for News Media UW-Extension In The News Social Media Resources Academic Affairs From the Provost Scholarship Governance ... Purchase Order Alert Get help with your small business Read chancellor communications Find online degree programs Explore UW Flexible Option ...

  11. Type extension trees

    DEFF Research Database (Denmark)

    Jaeger, Manfred

    2006-01-01

    We introduce type extension trees as a formal representation language for complex combinatorial features of relational data. Based on a very simple syntax this language provides a unified framework for expressing features as diverse as embedded subgraphs on the one hand, and marginal counts...... of attribute values on the other. We show by various examples how many existing relational data mining techniques can be expressed as the problem of constructing a type extension tree and a discriminant function....

  12. A Feasibility Study of Fuzzy FES Controller Based on Cycle-to-Cycle Control: An Experimental Test of Knee Extension Control

    Science.gov (United States)

    Watanabe, Takashi; Masuko, Tomoya; Arifin, Achmad; Yoshizawa, Makoto

    Functional Electrical Stimulation (FES) can be effective in assisting or restoring paralyzed motor functions. The purpose of this study is to examine experimentally the fuzzy controller based on cycle-to-cycle control for FES-induced gait. A basic experimental test was performed on controlling maximum knee extension angle with normal subjects. In most of control trials, the joint angle was controlled well compensating changes in muscle responses to electrical stimulation. The results show that the fuzzy controller would be practical in clinical applications of gait control by FES. An automatic parameter tuning would be required practically for quick responses in reaching the target and in compensating the change in muscle responses without causing oscillating responses.

  13. Hyperuricemia beyond 1 year after kidney transplantation in pediatric patients: Prevalence and risk factors

    Science.gov (United States)

    Einollahi, B.; Einollahi, H.; Rostami, Z.

    2012-01-01

    Hyperuricemia is frequent among adult renal transplant recipients; however, data among pediatric kidney recipients are scarce. This study is designed to estimate the prevalence and risk factors of late post-transplant hyperuricemia in pediatric recipients. A retrospective observational multicenter study on 179 pediatric renal recipients (5–18 years) was conducted between April 2008 and January 2011 from five kidney transplant centers of Tehran, Iran. All recipients were followed up for more than 1 year (5.9 ±3.3 years) after transplantation. A total of 17686 blood samples were obtained for serum uric acid (SUA). The normal range of SUA was defined as SUA 1.86–5.93 mg/dl for children between 2 and 15 years in both genders; 2.40–5.70 mg/dl for girls aged >15 years; 3.40–7.0 mg/dl for boys aged >15 and more than 6 and 7 mg/dl in boys and girls older than 15 years old. The median age of the children was 13 years. Male recipients were more popular than female (male/female 59/41%). Hyperuricemia was detected in 50.2% of patients. Mean SUA concentration was 5.9±1.7 mg/dl and mean SUA concentration in hyperuricemic patients was 7.7±1.2 mg/dl. While at multivariate logistic regression elevated serum creatinine concentration (P<0.001) and the time span after renal transplantation (P=0.02) had impact on late post-transplant hyperuricemia. High cyclosporine level (C0 and C2) was not risk factor for huperuricemia. Late post-transplant hyperuricemia was found in about half of pediatric renal recipients, and was associated with impaired renal allograft function. PMID:23162272

  14. Encouraging responses in sexual and relationship violence prevention: what program effects remain 1 year later?

    Science.gov (United States)

    Moynihan, Mary M; Banyard, Victoria L; Cares, Alison C; Potter, Sharyn J; Williams, Linda M; Stapleton, Jane G

    2015-01-01

    Colleges and universities are high-risk settings for sexual and relationship violence. To address these problems, institutions of higher education have implemented prevention programs, many of which train students as potential bystanders who can step in to help diffuse risky situations, identify and challenge perpetrators, and assist victims. The impact of bystander sexual and relationship violence prevention programs on long-term behavior of bystanders has remained a key unanswered question for those who seek to offer the most effective programs as well as for policy makers. In this study, the researchers experimentally evaluated the effectiveness of the Bringing in the Bystander® in-person program. Participants were 948 1st-year college students of whom 47.8% were women and 85.2% identified as White (15% also identified as Hispanic in a separate question) between the ages of 18 and 24 at two universities (one a rural, primarily residential campus and the other an urban, highly commuter campus) in the northeastern United States. To date, this is the first study to have found positive behavior changes as long-lasting as 1 year following an educational workshop focusing on engaging bystanders in preventing sexual and relationship violence. Even so, many questions remain to be answered about prevention and intervention of this type. More prospective research is needed on bystander-focused prevention of these forms of violence to help understand and better predict the complicated relationships both between and among the attitudes and behaviors related to preventing sexual and relationship violence. In this regard, we make specific recommendations for designing and evaluating programs based on our findings relating to the importance of moderators, especially two key understudied ones, readiness to help and opportunity to intervene.

  15. Motor performance after posteroventral pallidotomy and VIM-thalamotomy in Parkinson's disease: a 1-year follow-up study Desempenho motor após palidotomia póstero-ventral e talamotomia ventro-lateral na doença de Parkinson: acompanhamento de um ano

    Directory of Open Access Journals (Sweden)

    PATRÍCIA M. C. AGUIAR

    2000-09-01

    Full Text Available Twenty-three patients with Parkinson's disease underwent stereotactic surgery. To study the long-term motor performance, the patients were evaluated at the pre-operative period and at the 1st, 3rd, 6th, and 12th post-operative months, with the following scales: Unified Parkinson's Disease Rating Scale (UPDRS motor score and Larsen's Scale for Dyskinesias. The patients under levodopa therapy were assessed both in "on" and "off" periods. Fourteen unilateral ventrolateral thalamotomies (VLT, 4 unilateral posteroventral pallidotomies (PVP, 2 bilateral PVP, and 3 VLT with contralateral PVP were performed. The motor improvement was significant and long-lasting in the "off" period, except for 2 patients. The "on" period quality improved, mainly due to the control of dyskinesias. The improvement of dyskinesias was long-lasting for the majority of the patients. There was no significant decrease in the levodopa dose. Three patients showed permanent complications, but none was severe.Vinte e três pacientes portadores de doença de Parkinson foram submetidos a cirurgia estereotáxica para tratamento da doença. Com o objetivo de estudar o desempenho motor a longo prazo, os pacientes foram avaliados clinicamente no período pré-operatório, no 1°, 3°, 6°, e 12° mês pós-operatório, com as seguintes escalas: Escala Unificada para Doença de Parkinson (Unified Parkinson's Disease Rating Scale-UPDRS, item III, escore motor e com a Escala de Larsen para Discinesias. Os pacientes que utilizavam levodopa foram avaliados nos estados "off" e "on". Foram realizadas 14 talamotomias ventro-laterais (TVL unilaterais, 4 palidotomias póstero-ventrais (PPV unilaterais, 2 PPV bilaterais; 3 TVL associadas à PPV contralateral. O benefício motor foi observado de forma significante no estado "off", e manteve-se a longo prazo na maioria dos pacientes, exceto em 2. Houve melhora da qualidade do período "on", devido ao controle das discinesias. A melhora das

  16. 重度肥胖病人腹腔镜可调节胃束带术术后1年营养随访研究%Nutritional status after laparoscopic adjustable gastric banding in morbid obesity patients: A 1-year follow-up study

    Institute of Scientific and Technical Information of China (English)

    刘燕萍; 朱慧娟; 康维明; 赵宇星; 金洽儿; 于健春

    2012-01-01

    目的:探讨重度肥胖病人行腹腔镜可调节胃束带术(LAGB)前后营养管理方法,观察营养状态变化.方法:重度肥胖LAGB手术病人15例,术前至术后1年进行极低能量饮食干预,并测定术前、术后1、3、6和12个月的体重、超重部分减重%(EWL%)、体重指数(BMI)、骨骼肌、体脂%、血清清蛋白(ALB)、前清蛋白(PA)、总胆固醇(TC)、三酰甘油(TG),以评价能量、蛋白质营养状况及脂代谢变化,随访并发症发生情况.结果:至LAGB术后12个月,EWL%平均达到57.66%,蛋白质营养状况正常,TC、TG水平下降,脂代谢显著改善.15例病人并发症发生情况均有不同程度改善.结论:LAGB围手术期进行极低能量饮食干预及持续的营养管理能改善能量营养过剩,并维持营养状态正常.%Objective: The study aimed to evaluate the effectiveness of laparoscopic adjustable gastric banding (LAGB) surgery in morbidly obese patients. Methods: The nutrition levels of 15 morbidly obese patients were measured pre and post LAGB. Various medical indicators were recorded periodically to assess the energy, protein and lipometabolism. These indicators included preoperative body weight, postoperative body weight at 1 ,3,6,12 months, percentage of excess weight loss (EWL% ) , body mass index (BMI) , skeletal muscle, body fat percentage, plasma albumin (ALB) ,prealbumin (PA) , total cholesterol (TC) and triglyceride (TG). Complications were also followed up. Results: At 12 months after LAGB surgery,the average EWL% was 57. 66% , the protein nutrition sustained normal, the level of TC and TG decreased and lipometabolism was improved significantly. The complications in all patients were improved. Conclusion: A very-low-energy diet intervention and continuous nutrition care can improve over-nutrition and maintain the normal nutrition in the perioperative period of LAGB surgery.

  17. NACRE Update and Extension Project

    Science.gov (United States)

    Aikawa, Masayuki; Arai, Koji; Arnould, Marcel; Takahashi, Kohji; Utsunomiya, Hiroaki

    2006-04-01

    NACRE, the `nuclear astrophysics compilation of reaction rates', has been widely utilized in stellar evolution and nucleosynthesis studies since its publication in 1999. We describe here the current status of a Konan-Université Libre de Bruxelles (ULB) joint project that aims at its update and extension.

  18. Two isoforms of cyclooxygenase contribute to augmented endothelium-dependent contractions in femoral arteries of 1-year-old rats

    Institute of Scientific and Technical Information of China (English)

    Yi SHI; Ricky YK MAN; Paul M VANHOUTTE

    2008-01-01

    Aim: The present experiments were designed to study the changes in endothe-lium-dependent contractions with aging. Methods: The rat femoral arteries of 20-week and 1-year-old rats with and without endothelium were suspended in organ chambers to record isometric tension. The production of oxygen-derived free radicals in the endothelium was measured with 2',7'-dichiorodihydrofluorescein diacetate (DCF) using confocal microscopy. Protein presences were determined by Western blotting. Results: In the arteries from the 1-year-old rats, endothe-lium-dependent relaxations to A23187 were reduced, but the endothelium-depen-dent contractions to A23187 (in the presence of Nω-nitro-L-arginine methyl ester hydrochloride [L-NAME; an inhibitor of nitric oxide synthase]) were augmented, demonstrating endothelial dysfunction with aging. Indomethacin normalized the responses, suggesting that a cyclooxygenase (COX)-dependent contraction is prominent in aging. The endothelium-dependent contractions were also prevented by terntroban (a blocker of thromboxane-prostanoid receptors), confirming the activation of thromboxane-prostanoid receptors on vascular smooth muscle. Valeryl salicylate and NS-398 (preferential inhibitors of COX-1 and COX-2, respectively) partially reduced the response, indicating that both COX-1 and COX-2 are involved. Western blotting confirmed the upregulation of both isoforms in the arteries of the 1-year-old rats. In the presence of L-NAME, A23187 increased the DCF fluores-cence in the endothelium, demonstrating that the production of oxygen-derived free radicals contributes to endothelium-dependent contractions. The activity of catalase was reduced in the arteries with endothelium of 1-year-old rats, indicating that hydrogen peroxide is the likely mediator of increased oxidative stress in the aging endothelium. Conclusion: Endothelium-dependent contractions are aug-mented with aging. Oxidative stress potentiates the response, and both COX-1 and COX-2 are

  19. 抑郁障碍住院老年患者的躯体症状及治疗后转归的1年随访%Somatic symptoms and dynamic changes after treatment in elderly inpatients with depression:A 1-year follow-up study

    Institute of Scientific and Technical Information of China (English)

    赵贵淳; 梁英; 王骁; 李涛; 程瑶; 孙新宇

    2015-01-01

    Objective:To explore the characteristics of somatic symptoms and their dynamic changes after treatment in elderly inpatients with depression,so as to give supported data in differential diagnosis and management of somatic symptoms in the elderly patients.Methods:Totally 69 consecutively hospitalized depression patients(≥60 years)were enrolled in the study,and 62 of them completed the 12-month follow-up.The diagnoses were made according to International Statistical Classification of Diseases and Related Health Problem-10th revision(ICD-10) criteria.The Hamilton Depression Scale(HAMD),Hamilton Anxiety Scale(HAMA)and Somatic Symptom Self-rat-ing Scale-Somatic factor(SSS-S)were used to assess the severity of depression,anxiety and somatic symptoms, which were evaluated at baseline,2 weeks,4 weeks and the end of 12-monthr espectively.The Minimum Mental State Examination(MMSE)were used to evaluate cognitive function,and Global Assessment Function(GAF)were used to evaluate social function at the end of 12-month follow-up.Result:Somatic symptoms presented in the all patients at the stages of depressive episode.The most common ones were gastrointestinal symptoms(91%),dizzi-ness or headache(66%),cardiovascular symptoms(59%).SSS-S scores at 2 weeks and 4 weeks of antidepressant treatment were significantly improved compared with those of baseline,[(13.6 ±3.2),(12.4 ±2.8)vs.(17.1 ± 4.8),analyzed by repeated measures of ANOVA,P <0.05].The changes of SSS-S scores were positive associated to the changes of anxiety symptoms and the effect of physical diseases,analyzed by hierarchical linear model analy-sis.At the stages of rehabilitation,residual somatic symptoms were positive associated to the degree of anxiety symptoms(OR =2.132,P <0.05),and unrelated to the level of HAMD,MMSE and GAF scores analyzed by logis-tic regression analysis.Conclusion:Somatic symptoms are various in elderly inpatients with depression during the a-cute phase,which are improved greatly as effective

  20. Outcomes, infectiousness, and transmission dynamics of patients with extensively drug-resistant tuberculosis and home-discharged patients with programmatically incurable tuberculosis: a prospective cohort study

    KAUST Repository

    Dheda, Keertan

    2017-01-19

    Background: The emergence of programmatically incurable tuberculosis threatens to destabilise control efforts. The aim of this study was to collect prospective patient-level data to inform treatment and containment strategies. Methods: In a prospective cohort study, 273 South African patients with extensively drug-resistant tuberculosis, or resistance beyond extensively drug-resistant tuberculosis, were followed up over a period of 6 years. Transmission dynamics, infectiousness, and drug susceptibility were analysed in a subset of patients from the Western Cape using whole-genome sequencing (WGS; n=149), a cough aerosol sampling system (CASS; n=26), and phenotypic testing for 18 drugs (n=179). Findings: Between Oct 1, 2008, and Oct 31, 2012, we enrolled and followed up 273 patients for a median of 20·3 months (IQR 9·6-27·8). 203 (74%) had programmatically incurable tuberculosis and unfavourable outcomes (treatment failure, relapse, default, or death despite treatment with a regimen based on capreomycin, aminosalicylic acid, or both). 172 (63%) patients were discharged home, of whom 104 (60%) had an unfavourable outcome. 54 (31%) home-discharged patients had failed treatment, with a median time to death after discharge of 9·9 months (IQR 4·2-17·4). 35 (20%) home-discharged cases were smear-positive at discharge. Using CASS, six (23%) of 26 home-discharged cases with data available expectorated infectious culture-positive cough aerosols in the respirable range (<5 μm), and most reported inter-person contact with suboptimal protective mask usage. WGS identified 17 (19%) of the 90 patients (with available sequence data) that were discharged home before the diagnosis of 20 downstream cases of extensively drug-resistant tuberculosis with almost identical sequencing profiles suggestive of community-based transmission (five or fewer single nucleotide polymorphisms different and with identical resistance-encoding mutations for 14 drugs). 11 (55%) of these downstream

  1. Reorganization of Agricultural Extension toward Green Agriculture

    Directory of Open Access Journals (Sweden)

    Mohammad S. Allahyari

    2009-01-01

    Full Text Available Problem statement: Considering unsustainable agricultural conditions of Iran and organizational recession and inability of current extension organization to achieve sustainability, it seems that extension systems require a new organizational structure to achieve sustainability objectives. The purpose of the present study was to identify the most appropriate characteristics for extension organization toward green agriculture in Iran context. Approach: To fulfill this objective, a sample of 120 respondents was selected through simple random sampling technique. A survey study was applied as a methodology of research. A mailed questionnaire was used to collect the data. The response rate of questionnaire was 65.83% (N = 79. Appropriate descriptive statistics such as mean scores, standard deviations and variation ratio were used. Results: Extension experts believed that among important organizational characteristics of extension system for supporting green agriculture collaboration among research, extension, education organizations, farmers' associations, NGOs, rural credit agencies, transportation companies, considering local groups and learning organization had very high importance for supporting green agriculture. According to factor analysis, the implications for extension organization were categorized into two groups consisting: (1 Holistic organizations (2 Participatory organizations that those factors explained 67.54% of the total variance of the research variables. Conclusion: Identifying suitable extension mechanisms had important role for developing extension system. Therefore, identifying extension organizational characteristics for supporting green agriculture of Iran is one of the major approaches needs to be carefully thought and accurately implemented for the extension system development.

  2. Percutaneous fixation of fractures of the spine: 1-year clinical and radiological follow-up

    Directory of Open Access Journals (Sweden)

    Carlos Fernando Pereira da Silva Herrero

    2014-12-01

    Full Text Available Objective: To evaluate the preliminary results of the surgical treatment through minimally invasive fixation technique in patients with thoracolumbar spinal fractures. Methods: Retrospective study of 17 patients with fractures of thoracolumbar vertebrae who underwent surgery with percutaneous fixation in the period of 2009 to 2011. The clinical evaluation of the results was performed using the SF-36 and Oswestry questionnaires. The radiographic parameters evaluated were: fracture classification according to Magerl's criteria, wedge angle of the fractured vertebrae and bisegmental Cobb angle. These measurements were made in the preoperative, immediate postoperative and 1 year after surgery. Other data such as associated injuries, neurological deficit, post-surgical infection, loosening and breakage of implants were also considered. Results: The data revealed average scores above 80% in all domains of the SF-36 questionnaire while in Oswestry Questionnaire, 79% of patients had minimal or absent physical limitations with a mean score of 12.4±11.89%. The average Cobb angle for preoperative kyphosis was 5.53º±13.80o, 2.18º±13.38o in the early postoperative period and 5.26º±13.95o one year after surgery. The average correction obtained after surgery was 3.35º and the average correction loss was 3.19º. No complications such as post-surgical infection, permanent neurological deficits and implant loosening and breakage were observed. Conclusion: The surgical treatment of fractures of thoracolumbar vertebrae using a minimally invasive technique provides satisfactory clinical and radiographic results with low complication rates.

  3. Management of tongue and lip laceration due to dystonia in a 1-year-old infant

    Directory of Open Access Journals (Sweden)

    J P Beena

    2017-01-01

    Full Text Available This case report describes the management of tongue and lip lacerations due to dystonia in a 1-year-old infant. A splint was given to raise the bite and prevent repeated trauma and aid in healing of the oral tissue. This paper highlights the importance of pediatric dentist's role in improving quality of patient care in an intensive care unit.

  4. An Analysis of 1-Year Impacts of Youth Transition Demonstration Projects

    Science.gov (United States)

    Fraker, Thomas M.; Luecking, Richard G.; Mamun, Arif A.; Martinez, John M.; Reed, Deborah S.; Wittenburg, David C.

    2016-01-01

    This article examines the impacts of the Youth Transition Demonstration, an initiative of the Social Security Administration (SSA) to improve employment outcomes for youth with disabilities. Based on a random assignment design, the analysis uses data from a 1-year follow-up survey and SSA administrative records for 5,203 youth in six research…

  5. Blood pressure 1 year after stroke: the need to optimize secondary prevention

    DEFF Research Database (Denmark)

    Hornnes, Nete; Larsen, Klaus; Boysen, Gudrun

    2011-01-01

    stroke or transient ischemic attack were randomly assigned to either usual care or to 4 home visits by a nurse. During the visits, the nurse measured and recorded BP and provided individually tailored counseling on a healthy lifestyle. A total of 303 patients completed the 1-year follow up. No change...

  6. Enteroaggregative Escherichia coli in Daycare-A 1-Year Dynamic Cohort Study

    DEFF Research Database (Denmark)

    Hebbelstrup Jensen, Betina; Stensvold, Christen R; Struve, Carsten

    2016-01-01

    Enteroaggregative Escherichia coli (EAEC) has been associated with persistent diarrhea, reduced growth acceleration, and failure to thrive in children living in developing countries and with childhood diarrhea in general in industrialized countries. The clinical implications of an EAEC carrier...

  7. Vancomycin resistance, esp, and strain relatedness: a 1-year study of enterococcal bacteremia.

    Science.gov (United States)

    Harrington, S M; Ross, T L; Gebo, K A; Merz, W G

    2004-12-01

    The prevalence of esp, a gene associated with infection-derived and outbreak strains, in enterococcal blood isolates from 2002 was determined. Fifty-five of 137 (40.1%) Enterococcus faecalis isolates, 30 of 58 (51.7%) E. faecium isolates, 1 of 1 E. raffinosus isolate, 0 of 4 E. gallinarum isolates, and 0 of 1 E. casseliflavus isolate were positive. esp wasn't associated with vancomycin resistance (VR) or clinical service. VR E. faecium isolates were less genetically diverse than vancomycin-susceptible strains. A large cluster of VR isolates, belonging to esp-positive E. faecium, was revealed. These data support the hypothesis that esp and VR may contribute to dissemination of particular clones.

  8. Comparison between repaglinide and glipizide in Type 2 diabetes mellitus: a 1-year multicentre study

    DEFF Research Database (Denmark)

    Madsbad, Sten; Kilhovd, B; Lager, I

    2001-01-01

    AIMS: To evaluate the long-term effectiveness and safety of repaglinide, a novel prandial glucose regulator, in comparison with glipizide in the treatment of patients with Type 2 diabetes. METHODS: Diet or tablet-treated patients with Type 2 diabetes (n = 256; age 40-75 years, body mass index (BMI......) 20-35 kg/m2, HbA1c 4.2-12.8%), without signs of severe microvascular or macrovascular complications, were included in this double-blind, multicentre, parallel-group comparative trial. Patients were randomized at a 2:1 ratio to repaglinide, 1-4 mg at mealtimes, or glipizide, 5-15 mg daily. RESULTS......: Changes in fasting blood glucose (FBG) and HbA1c during the 12 months of treatment showed a significant difference in favour of repaglinide. In oral hypoglycaemic agents (OHA)-naive patients, HbA1c decreased in the repaglinide and glipizide groups by 1.5% and 0.3%, respectively (P

  9. Comparison between repaglinide and glipizide in Type 2 diabetes mellitus: a 1-year multicentre study

    DEFF Research Database (Denmark)

    Madsbad, Sten; Kilhovd, B; Lager, I;

    2001-01-01

    AIMS: To evaluate the long-term effectiveness and safety of repaglinide, a novel prandial glucose regulator, in comparison with glipizide in the treatment of patients with Type 2 diabetes. METHODS: Diet or tablet-treated patients with Type 2 diabetes (n = 256; age 40-75 years, body mass index (BMI...... with Type 2 diabetes, and is better than glipizide in controlling HbA1c and FBG levels, overall, and in OHA-naive patients....

  10. Circulating surfactant protein D is decreased in early rheumatoid arthritis: a 1-year prospective study

    DEFF Research Database (Denmark)

    Hoegh, S V; Lindegaard, H M; Sorensen, G L;

    2008-01-01

    Innate immune system abnormalities, e.g., mannan-binding lectin (MBL) genotype variants, have been demonstrated to modify the disease course of rheumatoid arthritis (RA). Surfactant protein D (SP-D) shares important structural and functional properties with MBL suggesting that SP-D may...... with traditional disease activity measures indicate that SP-D reflects a distinctive aspect in the RA pathogenesis....

  11. Little change of modifiable risk factors 1 year after stroke: a pilot study

    DEFF Research Database (Denmark)

    Hornnes, Nete; Larsen, Klaus; Boysen, Gudrun

    2010-01-01

    Recurrent stroke accounts for about 25% of admissions for acute stroke. For the prevention of recurrent cerebro and cardiovascular disease, stroke patients are advised to change modifiable stroke risk factors before discharge from stroke units.......Recurrent stroke accounts for about 25% of admissions for acute stroke. For the prevention of recurrent cerebro and cardiovascular disease, stroke patients are advised to change modifiable stroke risk factors before discharge from stroke units....

  12. Perceived Emotional Intelligence as Predictor of Psychological Adjustment in Adolescents: A 1-Year Prospective Study

    Science.gov (United States)

    Salguero, Jose M.; Palomera, Raquel; Fernandez-Berrocal, Pablo

    2012-01-01

    In recent years, emotional intelligence has appeared as a predictor of adults' mental health, but little research has examined its involvement in adolescents' psychological adjustment. In this paper, we analyzed the predictive validity of perceived emotional intelligence (attention to feelings, emotional clarity, and emotional repair) over…

  13. Pain and functional impairment 1 year after inguinal herniorrhaphy: a nationwide questionnaire study

    DEFF Research Database (Denmark)

    Bay-Nielsen, M; Perkins, F M; Kehlet, H

    2001-01-01

    of hernia, the different types of surgical repairs, or the different types of anesthesia. The second questionnaire was returned by 83%. Of these, 46 (4%) reported constant pain. The intensity of pain while at rest was moderate or severe in 40 (3%); with physical activity, pain was moderate or severe in 91...... (8%). Impairment of specific daily activities as a result of pain was reported by 194 (16.6%). Pain characteristics were predominantly sensory, with a low use of affective terms. CONCLUSION: One year after inguinal hernia repair, pain is common (28.7%) and is associated with functional impairment...... in more than half of those with pain. These factors should be addressed when discussing the need for surgical intervention for an inguinal hernia....

  14. Rotigotine transdermal system for long-term treatment of patients with advanced Parkinson's disease: results of two open-label extension studies, CLEOPATRA-PD and PREFER.

    Science.gov (United States)

    LeWitt, Peter A; Boroojerdi, Babak; Surmann, Erwin; Poewe, Werner

    2013-07-01

    Open-label extensions [studies SP516 (NCT00501969) and SP715 (NCT00594386)] of the CLEOPATRA-PD and PREFER studies were conducted to evaluate the safety, tolerability and efficacy of the dopaminergic agonist, rotigotine, over several years of follow-up in patients with advanced Parkinson's disease (PD). Eligible subjects completing the double-blind trials received open-label adjunctive rotigotine (≤16 mg/24 h) for up to 4 and 6 years in Studies SP516 and SP715, respectively. Safety and tolerability were assessed using adverse events, vital signs and laboratory parameters, and efficacy assessed using the unified Parkinson's disease rating scale (UPDRS). Of the 395 and 258 patients enrolled in the SP516 and SP715 studies, 48 and 45 % completed, respectively. Adverse events were typically dopaminergic effects [e.g., somnolence (18-25 %/patient-year), insomnia (5-7 %/patient-year), dyskinesias (4-8 %/patient-year) and hallucinations (4-8 %/patient-year)], or related to the transdermal application of a patch (application site reactions: 14-15 %/patient-year). There were no clinically relevant changes in vital signs or laboratory parameters in either study. Mean UPDRS part II (activities of daily living) and part III (motor function) total scores improved from double-blind baseline during dose titration, then gradually declined over the maintenance period. In study SP516, mean UPDRS part II and III total scores were 0.8 points above and 2.8 points below double-blind baseline, respectively, at end of treatment. In study SP715, mean UPDRS part II and III total scores were 4.1 points above and 0.2 points below baseline, respectively, at end of treatment. In these open-label studies, adjunctive rotigotine was efficacious with an acceptable safety and tolerability profile in patients with advanced PD for up to 6 years.

  15. EXTENSIVE READING IN CHINA

    Institute of Scientific and Technical Information of China (English)

    1996-01-01

    IntroductionMost teachers and students in China are quite familiar with the term‘extensive reading’,but how itshould be taught still remains a problem.This paper covers the aims of extensive reading and the methodsand materials used in the course.Then some practical suggestions will be given to make the course moreinteresting and efficient.According to Dzao(1990).extensive reading is‘the course where other reading skills-speed,predictionand making inference-can be developed,’and‘where there is practice in geting the gist,in summarisingmain ideas,in understanding the author’s purpose and theme...’.So the aims of this course are todevelop general reading skills,the ability,to read quickly and to grasp the main ideas of the text.Toachieve these,students must enlarge their vocabulary,so this is also regarded as one of the aims.

  16. Android Access Control Extension

    Directory of Open Access Journals (Sweden)

    Anton Baláž

    2015-12-01

    Full Text Available The main objective of this work is to analyze and extend security model of mobile devices running on Android OS. Provided security extension is a Linux kernel security module that allows the system administrator to restrict program's capabilities with per-program profiles. Profiles can allow capabilities like network access, raw socket access, and the permission to read, write, or execute files on matching paths. Module supplements the traditional Android capability access control model by providing mandatory access control (MAC based on path. This extension increases security of access to system objects in a device and allows creating security sandboxes per application.

  17. Recent extensions to GALPROP

    CERN Document Server

    Strong, A W

    2015-01-01

    Some recent extensions to the GALPROP cosmic-ray propagation package are described. The enhancements include: an accurate solution option, improved convection formulation, alternative spatial boundary conditions, polarized synchrotron emission, new magnetic field models, updated gamma-ray production cross-sections, free-free radio emission and absorption, primary positrons, additional injection spectral breaks, deuterium production by pp fusion, hadronic energy losses, improved HEALPix skymap format, compatibility with latest HEALPix release, and various bug fixes. The Explanatory Supplement has been extensively updated, including details of these enhancements. A compatible plot package GALPLOT for GALPROP output is also provided, as well as other related software.

  18. Roles of octopamine and dopamine in appetitive and aversive memory acquisition studied in olfactory conditioning of maxillary palpi extension response in crickets.

    Directory of Open Access Journals (Sweden)

    Yukihisa eMatsumoto

    2015-09-01

    Full Text Available Elucidation of reinforcing mechanisms for associative learning is an important subject in neuroscience. Based on results of our previous pharmacological studies in crickets, we suggested that octopamine and dopamine mediate reward and punishment signals, respectively, in associative learning. In fruit-flies, however, it was concluded that dopamine mediates both appetitive and aversive reinforcement, which differs from our suggestion in crickets. In our previous studies, the effect of conditioning was tested at 30 min after training or later, due to limitations of our experimental procedures, and thus the possibility that octopamine and dopamine were not needed for initial acquisition of learning was not ruled out. In this study we first established a conditioning procedure to enable us to evaluate acquisition performance in crickets. Crickets extended their maxillary palpi and vigorously swung them when they perceived some odors, and we found that crickets that received pairing of an odor with water reward or sodium chloride punishment exhibited an increase or decrease in percentages of maxillary palpi extension responses to the odor. Using this procedure, we found that octopamine and dopamine receptor antagonists impair acquisition of appetitive and aversive learning, respectively. This finding suggests that neurotransmitters mediating appetitive reinforcement differ in crickets and fruit-flies.

  19. Association of renal biomarkers with 3-month and 1-year outcomes among critically ill acute stroke patients.

    Directory of Open Access Journals (Sweden)

    Ying-Chih Huang

    Full Text Available BACKGROUND: The comparative relationships of widely recognized biomarkers of renal injury with short-term and long-term outcomes among critically ill acute stroke patients are unknown. We evaluated the impact of baseline albuminuria [urine albumin-creatinine ratio (UACR ≥ 30 mg/g] or low estimated glomerular filtration rate (eGFR<60 ml/min per 1.73 m(2 on stroke patients admitted to the intensive care unit (ICU. METHODS: We reviewed data on consecutive stroke patients admitted to a hospital ICU in Taiwan from September 2007 to August 2010 and followed-up for 1 year. Baseline UACR was categorized into <30 mg/g (normal, 30-299 mg/g (microalbuminuria, and ≥ 300 mg/g (macroalbuminuria, while eGFR was divided into ≥ 60, 45-59, and <45 ml/min per 1.73 m(2. The outcome measure was death or disability at 3-month and 1-year after stroke onset, assessed by dichotomizing the modified Rankin Scale at 3-6 versus 0-2. RESULTS: Of 184 consecutive patients, 153 (83% met study entry criteria. Mean age was 67.9 years and median admission NIHSS score was 16. Among the renal biomarkers, only macroalbuminuria was associated with poorer 3-month outcome (OR 8.44, 95% CI 1.38 to 51.74, P = 0.021 and 1-year outcome (OR 18.06, 95% CI 2.59 to 125.94, P = 0.003 after adjustment of relevant covariates. When ischemic and hemorrhagic stroke were analyzed separately, macroalbuminuria was associated with poorer 1-year outcome among ischemic (OR 17.10, 95% CI 1.04 to 280.07, P = 0.047 and hemorrhagic stroke patients (OR 1951.57, 95% CI 1.07 to 3561662.85, P = 0.048, respectively, after adjustment of relevant covariates and hematoma volume. CONCLUSIONS: Presence of macroalbuminuria indicates poor 3-month and 1-year outcomes among critically ill acute stroke patients.

  20. Extensions of tempered representations

    NARCIS (Netherlands)

    Opdam, E.; Solleveld, M.

    2013-01-01

    Let π, π′ be irreducible tempered representations of an affine Hecke algebra H with positive parameters. We compute the higher extension groups Ext nH(π,π′) explicitly in terms of the representations of analytic R-groups corresponding to π and π′. The result has immediate applications to the computa

  1. Mobile Applications for Extension

    Science.gov (United States)

    Drill, Sabrina L.

    2012-01-01

    Mobile computing devices (smart phones, tablets, etc.) are rapidly becoming the dominant means of communication worldwide and are increasingly being used for scientific investigation. This technology can further our Extension mission by increasing our power for data collection, information dissemination, and informed decision-making. Mobile…

  2. Examining eXtension: Diffusion, Disruption, and Adoption among Iowa State University Extension and Outreach Professionals

    Science.gov (United States)

    Taylor, Cayla; Miller, Greg

    2016-01-01

    As eXtension unveils its new membership model, Iowa State University Extension and Outreach must determine how best to support professionals and clientele using the technology. This article reports on a study that used the diffusion of innovations and disruptive innovation theories to assess Iowa Extension professionals' adoption and perceptions…

  3. Persistence of the effects of Cerebrolysin on cognition and qEEG slowing in vascular dementia patients: results of a 3-month extension study.

    Science.gov (United States)

    Muresanu, Dafin F; Alvarez, X Anton; Moessler, Herbert; Novak, Philipp H; Stan, Adina; Buzoianu, Anca; Bajenaru, Ovidiu; Popescu, Bogdan O

    2010-12-15

    The maintenance of the effects of Cerebrolysin, a peptidergic compound with neurotrophic activity, on cognitive performance and qEEG activity was investigated through a 12-week, open-label extension of a 4-week, randomised, placebo-controlled pilot study. Thirty-three out of 41 patients with mild-to-moderate severe probable vascular dementia (VaD) according to NINDS-AIREN participating in the double-blind phase of the study were also assessed at the follow-up visit at week 16. Patients received i.v. infusions of Cerebrolysin (10 or 30 mL) or placebo (saline) 5 days/week for 4 weeks. Neuropsychological evaluations and qEEG recordings were done at baseline, week 4 and week 16. The mean change in score from baseline in the ADAS-cog+ and the slow-to-fast qEEG power ratio (PR), used as an index of qEEG slowing, were the two primary endpoints. Correlations between changes in cognition and qEEG induced by the treatment were also assessed. At the week 16 follow-up visit, Cerebrolysin improved (pCerebrolysin on cognition and qEEG activity in VaD patients for at least 12 weeks after treatment cessation, and they suggest the potential utility of qEEG parameters as biomarkers for VaD clinical trials.

  4. Metabolic syndrome and aerobic fitness in patients with first-episode schizophrenia, including a 1-year follow-up

    DEFF Research Database (Denmark)

    Nyboe, L.; Vestergaard, C. H.; Moeller, M. K.

    2015-01-01

    OBJECTIVE: To compare the prevalence of metabolic syndrome (MetS) and metabolic abnormalities in patients with first-episode schizophrenia (FES) with sex- and age-matched healthy controls; to investigate changes in MetS during 1year of treatment; and to investigate predictors of MetS. METHODS......: Patients with FES (N=99) and healthy controls (N=50) were included in the study. MetS was defined according to IDF based on waist circumference (WC), blood pressure (BP), triglycerides (TG), high-density lipoprotein (HDL), and fasting-glucose. Data on physical activity, aerobic fitness, smoking...

  5. Sexual function in male patients with obstructive sleep apnoea after 1 year of CPAP treatment

    DEFF Research Database (Denmark)

    Petersen, Marian Christin; Kristensen, Ellids; Berg, Søren;

    2012-01-01

    year of CPAP treatment, a total of 207 CPAP-compliant male patients (age 26-77) received a survey with questions drawn from two self-administered questionnaires on sexuality - Life Satisfaction 11 (LiSat-11) and brief sexual function inventory (BSFI). For assessment of daytime sleepiness, we used...... the Epworth sleepiness scale (ESS). RESULTS: Response rate was 76%. We found no significant changes in satisfaction with relation to partner or life as a whole, but satisfaction with sexual life (LiSat-11) and both general and functional aspects of sexuality (BSFI) were significantly improved after 1 year......OBJECTIVE: Our objective was to investigate what impact 1 year of effective nocturnal continuous positive airway pressure (CPAP) treatment had on general and functional aspects of sexuality in male patients with a confirmed diagnosis of obstructive sleep apnoea (OSA). METHODS: Before and after 1...

  6. Cystone® for 1 year did not change urine chemistry or decrease stone burden in cystine stone formers.

    Science.gov (United States)

    Erickson, Stephen B; Vrtiska, Terri J; Canzanello, Vincent J; Lieske, John C

    2011-06-01

    Cystine kidney stones frequently recur because inadequate prevention exists. We recruited documented recurrent cystine kidney stone formers (6 men, 4 women, 44 ± 17 years) into a 2-phased study to assess safety and effectiveness of Cystone®, a herbal treatment used to prevent and facilitate passage of cystine kidney stones. The first phase was a randomized double-blinded 12 weeks crossover study assessing the effect of Cystone® versus placebo (2 tablets BID) on urinary chemistries. The second phase was an open label 1 year study of Cystone® to determine if renal stone burden decreased, as assessed by quantitative and subjective assessment of CT. There was no statistically significant change of urinary composition from baseline short (6 weeks) or long (52 weeks) term on Cystone®, including volume (2525, 2611, 2730 ml), pH (6.7, 6.7, 7.05), and cystine excretion (2770, 2889, 4025 μmol). Pre and post-CT was available in nine patients. Although seven kidneys lost stones spontaneously or surgically, overall stone burden increased in seven kidneys, was unchanged in nine, and fell in only two. Quantitative scoring increased in both the left and right kidneys (1602-1667 and 301-2064 volumetric units, respectively). Therefore, this study does not suggest that Cystone® has a favorable effect on urinary chemistries that could decrease cystine stone formation, nor does it appear to prevent stone growth or promote stone passage over a 1-year period.

  7. Evaluation of laryngoscopic view, intubation difficulty and sympathetic response during direct laryngoscopy in sniffing position and simple head extension: a prospective and randomized comparative study

    Directory of Open Access Journals (Sweden)

    Rashmi Pal

    2015-08-01

    Conclusion: Sniffing position provided better glottis visualization and intubation difficulty score and increased the success rate of intubation as compared to simple head extension. [Int J Res Med Sci 2015; 3(8.000: 1895-1901

  8. Changes in corneal topography and biomechanical properties after collagen cross linking for keratoconus: 1-year results

    Directory of Open Access Journals (Sweden)

    Mohammadreza Sedaghat

    2015-01-01

    Full Text Available Purpose: To evaluate changes in corneal topography and biomechanical properties after collagen cross-linking (CXL for progressive keratoconus. Patients and Methods: Collagen cross-linking was performed on 97 eyes. We assessed uncorrected visual acuity (UCVA and best corrected visual acuity (BCVA. Corneal topography indices were evaluated using placido disc topography, scanning slit anterior topography (Orbscan II, and rotating Scheimpflug topography (Pentacam. Specular microscopy and corneal biomechanics were evaluated. Results: A 1-year-follow-up results revealed that UCVA improved from 0.31 to 0.45 and BCVA changed from 0.78 to 0.84 (P < 0.001. The mean of average keratometry value decreased from 49.62 to 47.95 D (P < 0.001. Astigmatism decreased from 4.84 to 4.24 D (P < 0.001. Apex corneal thickness decreased from 458.11 to 444.46 mm. Corneal volume decreased from 56.66 to 55.97 mm 3 (P < 0.001. Posterior best fit sphere increased from 55.50 to 46.03 mm (P = 0.025. Posterior elevation increased from 99.2 to 112.22 mm (P < 0.001. Average progressive index increased from 2.26 to 2.56 (P < 0.001. A nonsignificant decrease was observed in mean endothelial count from 2996 to 2928 cell/mm 2 (P = 0.190. Endothelial coefficient of variation (CV increased nonsignificantly from 18.26 to 20.29 (P = 0.112. Corneal hysteresis changed from 8.18 to 8.36 (P = 0.552 and corneal resistance factor increased from 6.98 to 7.21(P = 0.202, so these changes were not significant. Conclusion: Visual acuity and K values improved after CXL. In spite of the nonsignificant increase in endothelial cell count and increase in the CV, CLX seems to be a safe treatment for keratoconus. Further studies with larger sample sizes and longer follow-up periods are recommended.

  9. Risk of Recurrent Helicobacter pylori Infection 1 Year After Initial Eradication Therapy in 7 Latin American Communities

    Science.gov (United States)

    Morgan, Douglas R.; Torres, Javier; Sexton, Rachael; Herrero, Rolando; Salazar-Martínez, Eduardo; Robert Greenberg, E.; Bravo, Luis Eduardo; Dominguez, Ricardo L.; Ferreccio, Catterina; Lazcano-Ponce, Eduardo C.; Meza-Montenegro, Maria Mercedes; Peña, Edgar M.; Peña, Rodolfo; Correa, Pelayo; Martínez, María Elena; Chey, William D.; Valdivieso, Manuel; Anderson, Garnet L.; Goodman, Gary E.; Crowley, John J.; Baker, Laurence H.

    2013-01-01

    Importance The long-term effectiveness of Helicobacter pylori eradication programs for preventing gastric cancer will depend on recurrence risk and individual and community factors. Objective To estimate risk of H pylori recurrence and assess factors associated with successful eradication 1 year after treatment. Design, Setting, and Participants Cohort analysis of 1463 randomized trial participants aged 21 to 65 years from 7 Latin American communities, who were treated for H pylori and observed between September 2009 and July 2011. Interventions Randomization to 1 of 3 treatment groups: 14-day lansoprazole, amoxicillin, and clarithromycin (triple therapy); 5-day lansoprazole and amoxicillin followed by 5-day lansoprazole, clarithromycin, and metronidazole (sequential); or 5-day lansoprazole, amoxicillin, clarithromycin, and metronidazole (concomitant). Participants with a positive (13) C-urea breath test (UBT) 6 to 8 weeks posttreatment were offered voluntary re-treatment with 14-day bismuth-based quadruple therapy. Measurements Recurrent infection after a negative posttreatment UBT and factors associated with successful eradication at 1-year follow-up. Results Among participants with UBT-negative results who had a 1-year follow-up UBT (n=1091), 125 tested UBT positive, a recurrence risk of 11.5% (95% CI, 9.6%–13.5%). Recurrence was significantly associated with study site (P=.03), nonadherence to initial therapy (adjusted odds ratio [AOR], 2.94; 95% CI, 1.31–6.13; P=.01), and children in the household (AOR, 1.17; 95% CI, 1.01–1.35 per child; P=.03). Of the 281 with positive posttreatment UBT results, 138 completed re-treatment, of whom 93 tested UBT negative at 1 year. Among the 1340 who had a 1-year UBT, 80.4% (95% CI, 76.4%–83.9%), 79.8% (95% CI, 75.8%–83.5%), and 77.8% (95% CI, 73.6%–81.6%) had UBT-negative results in the triple, sequential, and concomitant groups, respectively (P=.61), with 79.3% overall effectiveness (95% CI, 77.1%–81.5%). In a

  10. The role of health extension workers in improving utilization of maternal health services in rural areas in Ethiopia: a cross sectional study

    Directory of Open Access Journals (Sweden)

    Medhanyie Araya

    2012-10-01

    Full Text Available Abstract Background Community health workers are widely used to provide care for a broad range of health issues. Since 2003 the government of Ethiopia has been deploying specially trained new cadres of community based health workers named health extension workers (HEWs. This initiative has been called the health extension program. Very few studies have investigated the role of these community health workers in improving utilization of maternal health services. Methods A cross sectional survey of 725 randomly selected women with under-five children from three districts in Northern Ethiopia. We investigated women’s utilization of family planning, antenatal care, birth assistance, postnatal care, HIV testing and use of iodized salt and compared our results to findings of a previous national survey from 2005. In addition, we investigated the association between several variables and utilization of maternal health services using logistic regression analysis. Results HEWs have contributed substantially to the improvement in women’s utilization of family planning, antenatal care and HIV testing. However, their contribution to the improvement in health facility delivery, postnatal check up and use of iodized salt seems insignificant. Women who were literate (OR, 1.85, listened to the radio (OR, 1.45, had income generating activities (OR, 1.43 and had been working towards graduation or graduated as model family (OR, 2.13 were more likely to demonstrate good utilization of maternal health services. A model family is by definition a family which has fulfilled all the packages of the HEP. Conclusions The HEWs seem to have substantial contribution in several aspects of utilization of maternal health services but their insignificant contribution in improving health facility delivery and skilled birth attendance remains an important problem. More effort is needed to improve the effectiveness of HEWs in these regards. For example, strengthening HEWs

  11. Chinese Herbal Decoction Based on Syndrome Differentiation as Maintenance Therapy in Patients with Extensive-Stage Small-Cell Lung Cancer: An Exploratory and Small Prospective Cohort Study

    Directory of Open Access Journals (Sweden)

    Rui Liu

    2015-01-01

    Full Text Available Objective. To investigate the treatment effect and treatment length of Chinese herbal decoction (CHD as maintenance therapy on patients with extensive-stage small-cell lung cancer (ES-SCLC and to reflect the real syndrome differentiation (Bian Zheng practices of traditional Chinese medicine (TCM. Patients and Methods. Different CHDs were prescribed for each patient based on syndrome differentiation. The length of CHD treatment was divided into two phases for analyzing progression-free survival (PFS and postprogression survival (PPS. Results. Three hundred and fifty-seven CHDs were prescribed based on syndrome differentiation during the study period. Median PFS was significantly longer in patients who received CHD >3 months than patients who received CHD ≤3 months in the first phase (8.7 months versus 4.5 months; hazard ratio (HR, 0.52; 95% confidence interval (CI, 0.41–0.99; P=0.0009. Median PPS was significantly longer in patients who received CHD >7 months than patients who received CHD ≤7 months in the second phase (11.7 months versus 5.1 months; HR, 2.32; 95% CI, 1.90–2.74; P=0.002. Conclusion. CHD could improve PFS and PPS, which are closely related to treatment time and deepness of response of first-line therapy. In addition, CHD could improve body function and keep patients in a relatively stable state.

  12. Correlation between serum uric acid levels and clinical characteristics in patients with longitudinally extensive transverse myelitis A case-control study

    Institute of Scientific and Technical Information of China (English)

    Xiaofan You; Wei Qin; Jing Ye; Yonggang Hao; Wenhui Zhao; Wenli Hu

    2011-01-01

    Uric acid is reduced in demyelinating diseases, including multiple sclerosis and neuromyelitis optica (NMO).Longitudinally extensive transverse myelitis (LETM) is often an early manifestation of NMO.Whether uric acid levels are reduced at presentation of LETM remains unknown.The present study investigated serum uric acid levels by evaluating 35 patients with LETM, 64 with NMO, 62 with multiple sclerosis, 63 Mth other neurological diseases and 65 healthy controls.In addition, we tested the correlation between serum uric acid and the clinical characteristics of LETM.All patients were in the acute phase, defined as less than 1 month from onset or relapse.The results revealed that serum uric acid levels in LETM were significantly lower than in multiple sclerosis, other neurological diseases and healthy controls, but no difference was found between LETM and NMO.A negative correlation between uric acid levels and Expanded Disability Status Scale scores was found in LETM patients (r=-0.545, P < 0.05).The results suggest that uric acid levels are reduced in patients with LETM, raising the possibility that lower uric acid levels are an indicator of disease disability.Moreover, reduced uric acid levels may be a risk factor in NMO.

  13. The First Order Transfer Function in the Analysis of Agrochemical Data in Honey Bees (Apis Mellifera L.: Proboscis Extension Reflex (PER Studies

    Directory of Open Access Journals (Sweden)

    Lisa A. De Stefano

    2014-01-01

    Full Text Available This paper describes a mathematical model of the learning process suitable for studies of conditioning using the proboscis extension reflex (PER in honey bees when bees are exposed to agrochemicals. Although procedural variations exist in the way laboratories use the PER paradigm, proboscis conditioning is widely used to investigate the influence of pesticides and repellents on honey bee learning. Despite the availability of several mathematical models of the learning process, no attempts have been made to apply a mathematical model to the learning curve in honey bees exposed to agrochemicals. Our model is based on the standard transfer function in the form Y=B3 e-B2 (X-1 +B4(1-e-B2 (X-1 where X is the trial number, Y is the proportion of correct responses, B2 is the learning rate, B3 is readiness to learn, and B4 is ability to learn. We reanalyze previously published data on the effect of several classes of agrochemicals including: (1 those that are considered harmless to bees (e.g., pymetrozine, essential oils, dicofol; (2 sublethal exposure to pesticides known to harm honey bees (e.g., coumaphos, cyfluthrin, fluvalinate, permethrin; and (3 putative repellents of honey bees (e.g., butyric acid, citronella. The model revealed additional effects not detected with standard statistical tests of significance.

  14. An Assessment of Extension Education Curriculum at Land Grant Universities

    Science.gov (United States)

    Harder, Amy; Mashburn, Diane; Benge, Matt

    2009-01-01

    A critical assessment of extension education is needed to ensure there are adequate opportunities for students to study extension education and that the curriculum is relevant to today's Cooperative Extension Service. This descriptive study was conducted to assess extension education curriculum by identifying and comparing the courses being taught…

  15. Modal extension rule

    Institute of Scientific and Technical Information of China (English)

    WU Xia; SUN Jigui; LIN Hai; FENG Shasha

    2005-01-01

    Modal logics are good candidates for a formal theory of agents. The efficiency of reasoning method in modal logics is very important, because it determines whether or not the reasoning method can be widely used in systems based on agent. In this paper,we modify the extension rule theorem proving method we presented before, and then apply it to P-logic that is translated from modal logic by functional transformation. At last, we give the proof of its soundness and completeness.

  16. Longitudinally extensive optic neuritis in pediatric patients.

    Science.gov (United States)

    Graves, Jennifer; Kraus, Verena; Soares, Bruno P; Hess, Christopher P; Waubant, Emmanuelle

    2015-01-01

    Extensive optic nerve demyelinating lesions on magnetic resonance imaging (MRI) in adults could indicate a diagnosis other than multiple sclerosis with worse prognosis such as neuromyelitis optica. We report the frequency of longitudinally extensive lesions in children with first events of optic neuritis. Subjects had brain or orbit MRI within 3 months of onset and were evaluated at the University of California, San Francisco, Pediatric Multiple Sclerosis Center. Lesion length, determined by T2 hyperintensity or contrast enhancement, was blindly graded as absent, focal or longitudinally extensive (at least 2 contiguous segments of optic nerve). Of 25 subjects, 9 (36%) had longitudinally extensive optic neuritis. Extensive lesions were not associated with non-multiple sclerosis versus multiple sclerosis diagnosis (P = 1.00). No association between age and lesion extent was observed (P = .26). Prospective studies are needed to determine if longitudinally extensive optic neuritis can predict visual outcome.

  17. Aqua-Sim水声信道仿真平台扩展研究%Study on the Extension of Underwater Acoustic Channel with Aqua-Sim

    Institute of Scientific and Technical Information of China (English)

    李丹

    2014-01-01

    The simulator of underwater acoustic channel is one of the most important technologies to ocean network study and has been received extensive attention. Underwater acoustic channel is too complex and volatile to implement the computer simula-tor. For issues of existing studies on models and simulations of underwater acoustic channel, a modified simulator with Aqua-Sim is proposed. In order to build satisfactory experimental environments, the seawater characteristics, such as temperature, salinity, lati-tude, depth and so on, are set with the user interface, and are used as parameters for formulas of sound velocity and background noise. The simulation experiment shows that the effect of improved Aqua-Sim is closer to the actual seawater.%水声信道计算机仿真平台作为海洋网络研究的关键部分已受到广泛关注。由于水声信道具有复杂多变的特性,水声信道的普适性计算机仿真平台研究具有一定难度。本文针对现有水声信道仿真研究存在的问题,对Aqua-Sim水声信道仿真平台进行改进。将海水温度、盐度、纬度和深度等海域环境特征作为仿真平台水下声速和背景噪声计算参数,在仿真实验搭建过程中通过动态参数接口灵活搭建符合实验要求的仿真环境。仿真实验表明,改进后的Aqua-Sim平台仿真效果更加逼近实际海水信道环境。

  18. Mosaic: Policy Homomorphic Network Extension

    CERN Document Server

    Li, L Erran; Yang, Y R

    2010-01-01

    With the advent of large-scale cloud computing infrastructure, network extension and migration has emerged as a major challenge in the management of modern enterprise networks. Many enterprises are considering extending or relocating their network components, in whole or in part, to remote, private and public data centers, in order to attain scalability, failure resilience, and cost savings for their network applications. In this paper, we conduct a first rigorous study on the extension and migration of an enterprise network while preserving its performance and security requirements, such as layer 2/layer 3 reachability, and middle-box traversal through load balancer, intrusion detection and ACLs. We formulate this increasingly important problem, present preliminary designs, and conduct experiments to validate the feasibility of our designs.

  19. Linear programming foundations and extensions

    CERN Document Server

    Vanderbei, Robert J

    2001-01-01

    Linear Programming: Foundations and Extensions is an introduction to the field of optimization. The book emphasizes constrained optimization, beginning with a substantial treatment of linear programming, and proceeding to convex analysis, network flows, integer programming, quadratic programming, and convex optimization. The book is carefully written. Specific examples and concrete algorithms precede more abstract topics. Topics are clearly developed with a large number of numerical examples worked out in detail. Moreover, Linear Programming: Foundations and Extensions underscores the purpose of optimization: to solve practical problems on a computer. Accordingly, the book is coordinated with free efficient C programs that implement the major algorithms studied: -The two-phase simplex method; -The primal-dual simplex method; -The path-following interior-point method; -The homogeneous self-dual methods. In addition, there are online JAVA applets that illustrate various pivot rules and variants of the simplex m...

  20. NURBS curve blending using extension

    Institute of Scientific and Technical Information of China (English)

    Yong-jin LIU; Rong-qi QIU; Xiao-hui LIANG

    2009-01-01

    Curve and surface blending is an important operation in CAD systems, in which a non-uniform rational B-spline (NURBS) has been used as the de facto standard. In local comer blending, two curves intersecting at that comer are first made disjoint, and then the third blending curve is added-in to smoothly join the two curves with G1-or G2-continuity. In this paper we present a study to solve the joint problem based on curve extension. The following nice properties of this extension algorithm are exploited in depth: (1) The parameterization of the original shapes does not change; (2) No additional fragments are created.Various examples are presented to demonstrate that our solution is simple and efficient.

  1. Less extensive surgery compared to extensive surgery

    DEFF Research Database (Denmark)

    Lauszus, Finn F; Petersen, Astrid Christine; Neumann, Gudrun

    2014-01-01

    OBJECTIVE: To describe the outcome of adult granulosa cell tumor (AGCT) with respect to initial clinical findings, methods of surgery, and perioperative treatment. STUDY DESIGN: Retrospective follow-up study. Setting: All hospitals in Jutland. Sample: 163 women diagnosed with AGCT. Methods: Follow......-up by hospital data files, general practitioner, death certificate, and autopsy report. Revision of histopathology by a single pathologist. Main outcome measures: Survival and relapse by clinical data, stage, and type of surgery. RESULTS: The incidence of AGCT was 1.37 per year per 100,000 women (95% CI: 1.08, 1...... in postmenopausal women was associated with surgery including hysterectomy and bilateral oophorectomy (psurgery. Endometrial carcinoma was found 138 times (95% CI: 48, 275) more prevalent than the expected rate. CONCLUSION...

  2. Taxonomy for Assessing Evaluation Competencies in Extension

    Science.gov (United States)

    Rodgers, Michelle S.; Hillaker, Barbara D.; Haas, Bruce E.; Peters, Cheryl

    2012-01-01

    Evaluation of public service programming is becoming increasingly important with current funding realities. The taxonomy of evaluation competencies compiled by Ghere et al. (2006) provided the starting place for Taxonomy for Assessing Evaluation Competencies in Extension. The Michigan State University Extension case study described here presents a…

  3. CANONICAL EXTENSIONS OF SYMMETRIC LINEAR RELATIONS

    NARCIS (Netherlands)

    Sandovici, Adrian; Davidson, KR; Gaspar, D; Stratila, S; Timotin, D; Vasilescu, FH

    2006-01-01

    The concept of canonical extension of Hermitian operators has been recently introduced by A. Kuzhel. This paper deals with a generalization of this notion to the case of symmetric linear relations. Namely, canonical regular extensions of symmetric linear relations in Hilbert spaces are studied. The

  4. Tennessee Extension Agents' Perceptions of Performance Appraisal

    Science.gov (United States)

    Donaldson, Joseph L.; French, Russell L.

    2013-01-01

    Performance appraisal is necessary for summative decisions about employees, such as merit pay and promotion. The research reported here describes Extension agent perceptions of their performance appraisal system. The population studied consisted of all Tennessee Extension agents (N = 312). Surveys were completed by 218 respondents, for a completed…

  5. Mechanical heterogeneities and lithospheric extension

    Science.gov (United States)

    Duretz, Thibault; Petri, Benoit; Mohn, Geoffroy; Schenker, Filippo L.; Schmalholz, Stefan

    2016-04-01

    Detailed geological and geophysical studies of passive margins have highlighted the multi-stage and depth-dependent aspect of lithospheric thinning. Lithospheric thinning involves a variety of structures (normal faults, low angle detachments, extensional shear zones, extraction faults) and leads to a complex architecture of passive margins (with e.g. necking zone, mantle exhumation, continental allochthons). The processes controlling the generation and evolution of these structures as well as the impact of pre-rift inheritance are so far incompletely understood. In this study, we investigate the impact of pre-rift inheritance on the development of rifted margins using two-dimensional thermo-mechanical models of lithospheric thinning. To first order, we represent the pre-rift mechanical heterogeneities with lithological layering. The rheologies are kept simple (visco-plastic) and do not involve any strain softening mechanism. Our models show that mechanical layering causes multi-stage and depth-dependent extension. In the initial rifting phase, lithospheric extension is decoupled: as the crust undergoes thinning by brittle (frictional-plastic) faults, the lithospheric mantle accommodates extension by symmetric ductile necking. In a second rifting phase, deformation in the crust and lithospheric mantle is coupled and marks the beginning of an asymmetric extension stage. Low angle extensional shear zones develop across the lithosphere and exhume subcontinental mantle. Furthemore, crustal allochthons and adjacent basins develop coevally. We describe as well the thermal evolution predicted by the numerical models and discuss the first-order implications of our results in the context of the Alpine geological history.

  6. Necessity and Opportunity: the 1-Year Master's ABA Program at Auburn University.

    Science.gov (United States)

    Johnston, James M

    2016-05-01

    The Auburn University Master of Science program in Applied Behavior Analysis was designed to accommodate not only the requirements of the Behavior Analyst Certification Board for approved course sequences and practicum training, but unavoidable limitations in faculty and other resources. These limitations were incompatible with the more traditional 2-year curriculum model, so a 1-year program was designed that met the necessary conditions. This article describes the resulting academic and practicum curriculum, the key funding mechanisms that allowed the program to develop, and the opportunities and benefits that this model afforded.

  7. EXTENSIONS OF SOME INEQUALITIES

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    By using a simple analytic method the following inequalities are proved:(bx+y-ax+y)/(bx-ax)≥[(x+y)/x][(a+b)/2]y,for 0<a<b,x≥1,y>0,x+y≥2;(bx+y-ax+y)/(bx-ax)<[(x+y)/x][(a+b)/2]y,for0<a<b,0<x<1,y>0,x+y≤2.These inequalities are the extensions of inequalities of Qi Feng, Xu Senlin and Zheng Lin. And a conjection of Qi Feng is proved not true.

  8. Study of the Thermal Decomposition of PFPEs Lubricants on a Thin DLC Film Using Finitely Extensible Nonlinear Elastic Potential Based Molecular Dynamics Simulation

    Directory of Open Access Journals (Sweden)

    S. K. Deb Nath

    2014-01-01

    Full Text Available Perfluoropolyethers (PFPEs are widely used as hard disk lubricants for protecting carbon overcoat reducing friction between the hard disk interface and the head during the movement of head during reading and writing data in the hard disk. Due to temperature rise of PFPE Zdol lubricant molecules on a DLC surface, how polar end groups are detached from lubricant molecules during coating is described considering the effect of temperatures on the bond/break density of PFPE Zdol using the coarse-grained bead spring model based on finitely extensible nonlinear elastic potential. As PFPE Z contains no polar end groups, effects of temperature on the bond/break density (number of broken bonds/total number of bonds are not so significant like PFPE Zdol. Effects of temperature on the bond/break density of PFPE Z on DLC surface are also discussed with the help of graphical results. How bond/break phenomenonaffects the end bead density of PFPE Z and PFPE Zdol on DLC surface is discussed elaborately. How the overall bond length of PFPE Zdol increases with the increase of temperature which is responsible for its decomposition is discussed with the help of graphical results. At HAMR condition, as PFPE Z and PFPE Zdol are not suitable lubricant on a hard disk surface, it needs more investigations to obtain suitable lubricant. We study the effect of breaking of bonds of nonfunctional lubricant PFPE Z, functional lubricants such as PFPE Zdol and PFPE Ztetrao, and multidented functional lubricants such as ARJ-DS, ARJ-DD, and OHJ-DS on a DLC substrate with the increase of temperature when heating of all of the lubricants on a DLC substrate is carried out isothermally using the coarse-grained bead spring model by molecular dynamics simulations and suitable lubricant is selected which is suitable on a DLC substrate at high temperature.

  9. Use of the AngioSculpt scoring balloon for infrapopliteal lesions in patients with critical limb ischemia: 1-year outcome.

    Science.gov (United States)

    Bosiers, Marc; Deloose, Koen; Cagiannos, Catherine; Verbist, Jürgen; Peeters, Patrick

    2009-01-01

    The AngioSculpt Scoring Balloon Catheter (AngioScore, Inc., Fremont, CA) is composed of a semicompliant balloon encircled by three nitinol spiral struts providing targeted lesion scoring on balloon inflation. Between April 2005 and April 2006, procedural and follow-up data on 31 patients (mean age 76 years; 54.8% males) endovascularly treated for severe infrapopliteal disease were collected. The AngioSculpt catheter was used to treat 36 complex, tibioperoneal, atherosclerotic lesions. All patients had symptomatic critical limb ischemia (Rutherford 4-5) and single-vessel runoff to the ankle. Complication-free survival at 1 month was the safety end point, whereas primary patency and limb salvage were the efficacy end points evaluated at 1 year. The AngioSculpt balloon was successfully inflated in all 36 target lesions. Eleven patients (35.5%) required additional stenting for minor dissections or suboptimal stenosis reduction. The 1-month complication-free survival was 96.8%. One-year survival, primary patency, and limb salvage rates were 83.9 +/- 6.6%, 61.0 +/- 9.3%, and 86.3 +/- 6.4%, respectively. The 1-year data show the AngioSculpt Scoring Balloon Catheter to be an effective and safe treatment for infrapopliteal, atherosclerotic lesions in patients with critical limb ischemia. However, more patients, a longer follow-up, and randomized studies comparing it with conventional balloon angioplasty and stenting in the infrapopliteal region are required.

  10. Self-management of chronic pain in Malaysian patients: effectiveness trial with 1-year follow-up.

    Science.gov (United States)

    Cardosa, Mary; Osman, Zubaidah Jamil; Nicholas, Michael; Tonkin, Lois; Williams, Amanda; Abd Aziz, Khuzaimah; Mohd Ali, Ramli; Dahari, Norhana Mohd

    2012-03-01

    Self-management of chronic illnesses has been widely recognised as an important goal on quality of life, health service utilisation and cost grounds. This study describes the first published account on the application of this approach to people suffering from chronic pain conditions in a Southeast Asian country, Malaysia. A heterogeneous sample of chronic pain patients in Malaysia attended a 2-week cognitive-behavioural pain management programme (PMP) aimed at improving daily functional activities and general psychological well-being. Complete datasets from 70 patients out of 102 patients who attended 11 programmes conducted from 2002 to 2007, as well as the 1-month and 1-year follow-up sessions at the hospital clinic, are reported. The pre- to post-treatment results on self-report measures indicate that significant gains were achieved on the dimensions of pain, disability and psychological well-being. These gains were maintained at both 1-month and 1-year follow-ups. The results mirror those reported from similar interventions in Europe and North America and indicate the concept of self-management of a chronic illness is acceptable and meaningful to Asian patients. Importantly, the achieved outcomes were independent of gender and ethnic group status.

  11. Clinical performance of a resin-modified glass-ionomer and two polyacid-modified resin composites in cervical lesions restorations: 1-year follow-up.

    Science.gov (United States)

    Chinelatti, M A; Ramos, R P; Chimello, D T; Palma-Dibb, R G

    2004-03-01

    The aim of this study was to assess the clinical performance of a resin-modified glass-ionomer cement (Vitremer) and two polyacid-modified resin composites (F2000 and Freedom) over 1 year. Nineteen patients with at least three cervical lesions were selected, providing an initial sample size of 87 restorations (29 per material), being 78 to non-carious and nine to carious lesions. Restorations were evaluated at baseline, 6 months and 1 year after placement, using modified US Public Health Service criteria: colour match, marginal discoloration, caries, anatomical form, marginal integrity and surface texture. At baseline, restorations were considered as acceptable for all criteria. At 1-year recall, 21 restorations per material were re-examined. Freedom was rated Bravo or Charlie for all the examined criteria and Vitremer earned an Alfa rating solely for the criterion caries. On the contrary, F2000 showed the best overall results, although presenting significant alteration in colour match. Statistical analysis of data was performed using chi-square and Mc Nemar tests. As to the evaluated periods, significant difference was observed solely between baseline and 1-year recall. Freedom and Vitremer were statistically different (P < 0.01) as to anatomical form and surface texture. For F2000, significant difference (P < 0.05) was noticed as to colour match and anatomical form. After 1-year follow-up, F2000 showed the most acceptable results as to the analysed criteria.

  12. The safety and tolerability of vortioxetine: Analysis of data from randomized placebo-controlled trials and open-label extension studies.

    Science.gov (United States)

    Baldwin, David S; Chrones, Lambros; Florea, Ioana; Nielsen, Rebecca; Nomikos, George G; Palo, William; Reines, Elin

    2016-03-01

    The safety and tolerability of vortioxetine in adults with major depressive disorder was assessed. Tolerability was based on the nature, incidence and severity of treatment-emergent adverse events (TEAEs) during acute (6/8) week treatment in 11 randomized, double-blind placebo-controlled short-term studies in major depressive disorder: six with an active reference. Symptoms following discontinuation were assessed through the Discontinuation-Emergent Signs and Symptoms checklist in three studies. Long-term (⩽52 weeks) tolerability was evaluated in five open-label extension studies. Patients (n =5701) were acutely treated with either placebo (n=1817), vortioxetine (5-20mg/day; n=3018), venlafaxine XR (225mg/day; n=113) or duloxetine (60mg/day; n=753). The withdrawal rate due to TEAEs during treatment with vortioxetine (5-20mg/day) was 4.5-7.8%, compared with placebo (3.6%), venlafaxine XR (14.2%) or duloxetine (8.8%). Common TEAEs (incidence ⩾5% and >2 × placebo) with vortioxetine (5-20mg/day) were nausea (20.9-31.2%) and vomiting (2.9-6.5%). For vortioxetine (5-20mg/day), the incidence of TEAEs associated with insomnia was 2.0-5.1% versus 4.0% for placebo, and with sexual dysfunction 1.6-1.8% versus 1.0% for placebo. Discontinuation symptoms as assessed by the mean Discontinuation-Emergent Signs and Symptoms total score after abrupt discontinuation were comparable to placebo in the first and second week. Vortioxetine had no effect relative to placebo on clinical laboratory parameters, body weight, heart rate or blood pressure. Vortioxetine showed no clinically relevant effect on ECG parameters, including the QTcF interval. In long-term treatment, no new types of TEAEs were seen; the mean weight gain was 0.7-0.8kg. Thus, vortioxetine (5-20mg/day) appears safe and generally well tolerated in the treatment of major depressive disorder.

  13. FIELD TEST INSTRUCTION 100-NR-2 OPERABLE UNIT DESIGN OPTIMIZATION STUDY FOR SEQUESTRATION OF SR-90 SATURATED ZONE APATITE PERMEABLE REACTIVE BARRIER EXTENSION

    Energy Technology Data Exchange (ETDEWEB)

    BOWLES NA

    2010-10-06

    The objective of this field test instruction is to provide technical guidance for aqueous injection emplacement of an extension apatite permeable reactive barrier (PRE) for the sequestration of strontium-90 (Sr-90) using a high concentration amendment formulation. These field activities will be conducted according to the guidelines established in DOE/RL-2010-29, 100-NR-2 Design Optimization Study, hereafter referred to as the DOS. The DOS supports the Federal Facility Agreement Consent Order (EPA et al., 1989), Milestone M-16-06-01, and 'Complete Construction of a Permeable Reactive Barrier at 100-N.' Injections of apatite precursor chemicals will occur at an equal distance intervals on each end of the existing PRE to extend the PRB from the existing 91 m (300 ft) to at least 274 m (900 ft). Field testing at the 100-N Area Apatite Treatability Test Site, as depicted on Figure 1, shows that the barrier is categorized by two general hydrologic conceptual models based on overall well capacity and contrast between the Hanford and Ringold hydraulic conductivities. The upstream portion of the original barrier, shown on Figure 1, is characterized by relatively low overall well specific capacity. This is estimated from well development data and a lower contrast in hydraulic conductivity between the Hanford formation and Ringold Formations. Comparison of test results from these two locations indicate that permeability contrast between the Hanford formation and Ringold Formation is significantly less over the upstream one-third of the barrier. The estimated hydraulic conductivity for the Hanford formation and Ringold Formation over the upstream portion of the barrier based on observations during emplacement of the existing 91 m (300 ft) PRB is approximately 12 and 10 m/day (39 and 32 ft/day), respectively (PNNL-17429). However, these estimates should be used as a rough guideline only, as significant variability in hydraulic conductivity is likely to be observed in

  14. Induction of Maturogenesis by Partial Pulpotomy: 1 Year Follow-Up

    Directory of Open Access Journals (Sweden)

    A. Bacaksiz

    2013-01-01

    Full Text Available In cariously exposed immature permanent teeth, the treatment choice is controversial in pediatric dentistry. Radical root canal treatment usually appears to be the solution for these teeth. Even partial pulpotomy is a vital treatment for traumatically exposed immature permanent teeth; extending the borders of indication towards cariously exposed immature permanent teeth with reversible pulpitis may abolish the necessity of pulpectomy. This article describes the partial pulpotomy of a cariously affected immature permanent teeth and the follow-up for 1 year. A healthy 11-year-old male patient was referred to Gazi University Faculty of Dentistry Department of Pediatric Dentistry. The patient had reversible pulpitis symptoms on teeth numbered 45. At radiographic examination, immature apex and deep caries lesion were observed and partial pulpotomy was performed by using calcium hydroxide to maintain vitality of the pulp and allow continued development of root dentin expecting the root will attain full maturity. Clinical and radiographic follow-up demonstrated a vital pulp besides not only closure of the apex (apexogenesis, but also physiologic root development (maturogenesis after 1 year. Partial pulpotomy is an optional treatment for cariously exposed immature permanent teeth for preserving vitality and physiological root development.

  15. Learning to learn with farmers. A case study of an adult learning extension project conducted in Queensland, Australia 1990-1995.

    NARCIS (Netherlands)

    Hamilton, N.A.

    1995-01-01

    In this thesis, the relationship between the use of participatory processes in the development and use of information and knowledge and their impact on change is described and explored. This research utilises a major extension project carried out with respect to fallow management in southern Queensl

  16. Manipulation does not add to the effect of extension exercises in chronic low-back pain (LBP). A randomized, controlled, double blind study

    DEFF Research Database (Denmark)

    Rasmussen, J.; Laetgaard, J.; Lindecrona, A.L.;

    2008-01-01

    by a visual analogue scale. RESULTS: Pain in both back and leg decreased without differences between groups. Segmental binding of the low-back was associated with persisting clinical symptoms at four weeks. CONCLUSION: No additional effect was demonstrated of manipulation, when extension exercises were used...

  17. Calcific tendinopathy of the shoulder with intraosseous extension: outcomes of ultrasound-guided percutaneous irrigation

    Energy Technology Data Exchange (ETDEWEB)

    Klontzas, Michail E. [University Hospital and Department of Radiology, University of Crete, Department of Medical Imaging, Heraklion, Crete (Greece); Imperial College London, Department of Chemical Engineering, London (United Kingdom); Vassalou, Evangelia E.; Karantanas, Apostolos H. [University Hospital and Department of Radiology, University of Crete, Department of Medical Imaging, Heraklion, Crete (Greece)

    2017-02-15

    Rotator cuff calcific tendinopathy (RCCT) with intraosseous extension is a rare complication of tendinous and peritendinous involvement. The purpose of our study is to evaluate the outcome of ultrasound-guided percutaneous irrigation of calcific tendinopathy (US-PICT) in patients with intraosseous involvement. From January 2011 to June 2014, patients with a clinical and imaging diagnosis of RCCT were prospectively categorised in two groups based on imaging findings: group A (10 patients) with intraosseous RCCT and group B (control group 35 patients) without osseous involvement. US-PICT followed by subacromial injection was applied to all patients in groups A and B. During a 1-year follow-up, treatment outcome in terms of pain and functional improvement was evaluated at 3 weeks, 3 months, 6 months, and 1 year, with the use of a four-grade scale. The study has been approved by our hospital's ethics committee. Mean improvement scores of group A were significantly lower than those of group B at all time points (p < 0.0001). Improvement of group B was noted mainly within the first 3 months post-treatment (p = 0.016). Outcomes of ultrasound-guided treatment in cases of RCCT with intraosseous extension are significantly less favourable than in purely tendinous or peritendinous disease. (orig.)

  18. Solutions to Burnout and Retention as Perceived by County Extension Agents of the Colorado State University Extension System

    OpenAIRE

    Matt Benge; Amy Harder; Jeff Goodwin

    2015-01-01

    This study explored solutions to the issue of burnout and retention of Extension agents. Extension agents experience burnout for reasons such as long hours, stress, and organizational factors. As Extension administration addresses job satisfaction and performance of Extension employees, burnout and retention issues identified in this study can facilitate efforts to enhance the effectiveness of a statewide Extension program. Herzberg’s Motivation-Hygiene Theory was the theoretical framework fo...

  19. A new wide-diameter bone-anchored hearing implant-prospective 1-year data on complications, implant stability, and survival

    DEFF Research Database (Denmark)

    Foghsgaard, Søren; Caye-Thomasen, Per

    2014-01-01

    OBJECTIVE: To investigate a new wide bone-anchored hearing implant considering initial stability, stability over time, implant loss, and skin reaction. STUDY DESIGN: Consecutive, prospective case series. SETTING: Tertiary referral center. PATIENTS: Twenty adult patients were enrolled. All......, and 1 year after surgery. Skin and soft tissue reactions according to Holgers grading system. RESULTS: Implant stability quotient measurements revealed a significant increase in ISQ during the first 10 days after operation, and the ISQ values continued to rise throughout the 1-year observation period...

  20. Urinary incontinence during pregnancy and 1 year after delivery in primiparous women compared with a control group of nulliparous women

    DEFF Research Database (Denmark)

    Hansen, Bent Brandt; Svare, Jens; Viktrup, Lars

    2012-01-01

    AIMS: To investigate the impact of the first pregnancy and delivery on the prevalence and types of urinary incontinence during pregnancy and 1 year after delivery. METHODS: The study was a prospective cohort study with a control group. Primiparous women, who delivered in our department from June......, the prevalence of any type of urinary incontinence in the primiparous group was 32.1%, compared to 13.8% in the control group. Adjusted OR¿=¿3.3 (95%CI¿=¿2.4-4.4). One year after delivery, the prevalence in the primiparous group was 29.3%, compared to 16.6% in the control group. Adjusted OR¿=¿2.5 (95%CI¿=¿1...... in the primiparous group. The symptoms and impact on quality of life seemed to be mild to moderate in both groups. Neurourol. Urodynam. © 2011 Wiley Periodicals, Inc....

  1. Correlates of 1-year incidence of urinary incontinence in older Latino adults enrolled in a community-based physical activity trial.

    Science.gov (United States)

    Morrisroe, Shelby N; Rodriguez, Larissa V; Wang, Pin-Chieh; Smith, Ariana L; Trejo, Laura; Sarkisian, Catherine A

    2014-04-01

    The prevalence of urinary incontinence (UI) among older urban Latinos is high. Insight into etiologies of and contributing factors to the development of this condition is needed. This longitudinal cohort study identified correlates of 1-year incidence of UI in older community-dwelling Latino adults participating in a senior center-based physical activity trial in Los Angeles, California. Three hundred twenty-eight Latinos aged 60 to 93 participating in Caminemos, a randomized trial to increase walking, were studied. Participants completed an in-person survey and physical performance measures at baseline and 1 year. UI was measured using the International Consultation on Incontinence item: "How often do you leak urine?" Potential correlates of 1-year incidence of UI included sociodemographic, behavioral, medical, physical, and psychosocial characteristics. The overall incidence of UI at 1 year was 17.4%. Incident UI was associated with age, baseline activity of daily living impairment, health-related quality of life (HRQoL), mean steps per day, and depressive symptoms. Multivariate logistic regression models revealed that improvement in physical performance score (odds ratio (OR) = 0.69, 95% confidence interval (CI) = 0.50-0.95) and high baseline physical (OR = 0.60, 95% CI = 0.40-0.89) and mental (OR = 0.62, 95% CI = 0.43-0.91) HRQoL were independently associated with lower rates of 1-year incident UI. An increase in depressive symptoms at 1 year (OR = 4.48, 95% CI = 1.02-19.68) was independently associated with a higher rate of incident UI. One-year UI incidence in this population of older urban Latino adults participating in a walking trial was high but was lower in those who improved their physical performance. Interventions aimed at improving physical performance may help prevent UI in older Latino adults.

  2. Retrospective study of irinotecan/cisplatin followed by etoposide/cisplatin or the reverse sequence in extensive-stage small cell lung cancer

    Directory of Open Access Journals (Sweden)

    Xiao XG

    2015-08-01

    Full Text Available Xiaoguang Xiao, Shujing Wang, Shu Xia, Man Zou, Yang Li, Yao Wei, Qi Mei, Yuan Chen Department of Oncology, Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, People’s Republic of China Background: Much research has confirmed the favorable effect of irinotecan/cisplatin (IP and etoposide/cisplatin (EP on extensive-stage small cell lung cancer (E-SCLC. This study investigated two sequential orders of IP and EP in the treatment of E-SCLC. We also compared the efficacy and safety of IP and EP in first-line chemotherapy in E-SCLC. Methods: Ninety-three untreated patients with E-SCLC were randomly allocated to two groups. Group A received IP as first-line therapy until progression and then changed to EP; group B received EP as first-line therapy until tumor progression followed by IP. The primary endpoints were overall survival and time to second tumor progression. The secondary endpoints were first progression-free survival (PFS, ie, time from randomization to first occurrence of tumor progression after first-line treatment with IP or EP, tumor response, and safety of the different sequential treatment orders of IP and EP. Results: Median overall survival was 15.4 months in group A (IP followed by EP versus 15.7 months in group B (EP followed by IP; P=0.483. The median time to second tumor progression was 9.5 months in group A versus 9.9 months in group B (P=0.361. As first-line and second-line therapy, IP achieved a 95.9% and 60% disease control rate, respectively, and EP achieved 95.6% and 59% disease control rate. The median first PFS was not significantly different between group A and group B (6.5 months and 6.3 months, respectively; P=0.256. Grade 3/4 diarrhea appeared to be significantly more frequent with IP than with EP. The probability of anemia and thrombocytopenia was not significantly different between the two groups. However, significantly more patients who received the IP regimen as

  3. Type-D personality but not depression predicts severity of anxiety in heart failure patients at 1-year follow-up

    DEFF Research Database (Denmark)

    Schiffer, Angélique A; Pedersen, Susanne S.; Broers, Herman

    2008-01-01

    Chronic heart failure (CHF) is a debilitating condition associated with poor outcome, including increased anxiety. However, anxiety and its determinants have not yet been studied systematically in CHF. We examined whether type-D personality and depressive symptoms would predict clinically...... significant anxiety at 1-year follow-up....

  4. Er:YAG pre-treatment for bonding of orthodontic bracket: 1 year of in vitro treatment

    Science.gov (United States)

    de Jesus Tavarez, Rudys Rodolfo; Lima Bezerra, Gisele; de Souza Penha, Karla Janilee; Torres, Carlos Rocha Gomes; Firoozmand, Leily Macedo

    2017-01-01

    Objective The aim of this study was to evaluate in vitro bond strength of metal brackets bonded with: total etch, total etch with erbium: yttrium aluminum garnet laser (Er:YAG) and self-etching adhesive systems, submitted to thermal-mechanical cycling, simulating 1 year of orthodontic treatment. Materials and methods For the study, 80 bovine incisors were randomly divided into 3 experimental groups (n=16 each): XT- acid etching + Transbond XT, XT/Er:YAG- Transbond XT associated with Er:YAG laser irradiation (λ=2.94 μm, 60 mJ, 10 Hz) and SEP- Transbond Plus Self Etching Primer. Samples were submitted to thermal-mechanical cycling, simulating 1 year of orthodontic treatment. Afterward, the shear bond strength test was performed in a universal test machine at a speed of 0.5mm/min. Samples were evaluated under a stereomicroscope and by scanning electron microscopy for analysis of enamel surface and adhesive remnant index. Data were analyzed using Kruskal–Wallis and Mann–Whitney (with Bonferroni correction) statistical tests. Results Statistically significant difference was observed between the groups studied (p<0.05). Groups XT and SEP showed the highest bond strength values, without statistical difference between them, while group XT/Er:YAG showed reduction in bond strength values. Higher frequency of adhesive failures between enamel and adhesive system was verified for groups XT and XT/Er:YAG. Conclusion The conventional (XT) and self-etching (SEP) adhesive systems showed mean bond strength values, similar between them, whereas the previous application of Er:YAG laser promoted the lowest bond strength values.

  5. Shock-wave therapy for tennis and golfer's elbow--1 year follow-up.

    Science.gov (United States)

    Krischek, O; Hopf, C; Nafe, B; Rompe, J D

    1999-01-01

    Thirty patients with chronic medial epicondylitis were treated with low-energy shock waves. They received 500 impulses of 0.08 mJ/mm2 three times at weekly intervals. At 1 year follow-up examinations were performed. According to the Verhaar criteria, only seven patients reached excellent or good results. In eight cases a fair outcome was recorded, and in 14 patients the outcome was poor. Only six patients were satisfied with the treatment. The average relief of pain was 32%. These data were significantly worse than for identically treated patients with chronic tennis elbow. Thus, the question arises as to whether extracorporal shock-wave therapy is indicated in medial epicondylitis.

  6. A histopathological score on baseline biopsies from elderly donors predicts outcome 1 year after renal transplantation

    DEFF Research Database (Denmark)

    Toft, Birgitte G; Federspiel, Birgitte H; Sørensen, Søren S

    2012-01-01

    Kidneys from elderly deceased patients and otherwise marginal donors may be considered for transplantation and a pretransplantation histopathological score for prediction of postoperative outcome is warranted. In a retrospective design, 29 baseline renal needle biopsies from elderly deceased donors...... wall thickness of arteries and/or arterioles. Nineteen renal baseline biopsies from 15 donors (age: 64 ± 10 years) were included and following consensus the histopathological score was 4.3 ± 2.1 (intraclass correlation coefficient: 0.81; confidence interval: 0.66-0.92). The donor organs were used...... for single renal transplantation (recipient age: 47 ± 3 years). Two grafts were lost after the transplantation. In the remaining 17 recipients the 1-year creatinine clearance (54 ± 6 mL/min) correlated to the baseline histopathological score (r(2) = 0.59; p

  7. Safety and efficacy of nurse-controlled analgesia in patients less than 1 year of age

    Directory of Open Access Journals (Sweden)

    Walia H

    2016-06-01

    Full Text Available Hina Walia,1 Dmitry Tumin,1 Sharon Wrona,1 David Martin,1,2 Tarun Bhalla,1,2 Joseph D Tobias,1-3 1Department of Anesthesiology and Pain Medicine, Nationwide Children’s Hospital, 2Department of Anesthesiology and Pain Medicine, 3Department of Pediatrics, The Ohio State University College of Medicine, Columbus, OH, USA Background: The management of acute pain presents unique challenges in the younger pediatric population. Although patient-controlled devices are frequently used in patients ≥6 years of age, alternative modes of analgesic delivery are needed in infants.Objective: To examine the safety and efficacy of nurse-controlled analgesia (NCA in neonates less than 1 year of age.Methods: Data from patients <1 year of age receiving NCA as ordered by the Acute Pain Service at our institution were collected over a 5-year period and reviewed retrospectively. The primary outcomes were activation of the institution’s Rapid Response Team (RRT or Code Blue, signifying severe adverse events. Pain score after NCA initiation was a secondary outcome.Results: Among 338 girls and 431 boys, the most common opioid used for NCA was fentanyl, followed by morphine and hydromorphone. There were 39 (5% cases involving RRT or Code Blue activation, of which only one (Code Blue was activated due to a complication of NCA (apnea. Multivariable logistic regression demonstrated morphine NCA to be associated with greater odds of RRT activation (OR=3.29, 95% CI=1.35, 8.03, P=0.009 compared to fentanyl NCA. There were no statistically significant differences in pain scores after NCA initiation across NCA agents.Conclusion: NCA is safe in neonates and infants, with comparable efficacy demonstrated for the three agents used. The elevated incidence of RRT activation in patients receiving morphine suggests caution in its use and consideration of alternative agents in this population. Keywords: nurse-controlled analgesia, pain medicine, Rapid Response Team

  8. Perinatal dioxin exposure and the neurodevelopment of Vietnamese toddlers at 1 year of age.

    Science.gov (United States)

    Pham, Tai The; Nishijo, Muneko; Nguyen, Anh Thi Nguyet; Tran, Nghi Ngoc; Van Hoang, Luong; Tran, Anh Hai; Nguyen, Trung Viet; Nishijo, Hisao

    2015-12-01

    Dioxin concentrations remain elevated in both the environment and in humans residing near former US Air Force bases in South Vietnam. This may potentially have adverse health effects, particularly on infant neurodevelopment. We followed 214 infants whose mothers resided in a dioxin-contaminated area in Da Nang, Vietnam, from birth until 1 year of age. Perinatal exposure to dioxins was estimated from toxic equivalent (TEQ) levels of polychlorinated dibenzodioxins and polychlorinated dibenzofurans (PCDDs/Fs-TEQ), and 2,3,7,8-tetrachlorodibenzo-p-dioxin (2,3,7,8-TetraCDD) concentrations in breast milk. In infants, daily dioxin intake (DDI) was used as an index of postnatal exposure through breastfeeding. Neurodevelopment of toddlers was assessed using the Bayley Scales of Infant and Toddler Development, Third Edition (Bayley-III). No significant differences in neurodevelopmental scores were exhibited for cognitive, language or motor functions between four exposure groups of PCDDs/Fs-TEQ or 2,3,7,8-TetraCDD. However, social-emotional scores were decreased in the high PCDDs/Fs-TEQ group and the high 2,3,7,8-TetraCDD group compared with those with mild exposure, after adjusting for confounding factors. Cognitive scores in the mild, moderate, and high DDI groups were significantly higher than those in low DDI group, but there were no differences in cognitive scores among the three higher DDI groups. These results suggest that perinatal exposure to dioxins may affect social-emotional development of 1-year-old toddlers, without diminishing global neurodevelopmental function.

  9. Quotient Semigroups and Extension Semigroups

    Indian Academy of Sciences (India)

    Rong Xing; Changguo Wei; Shudong Liu

    2012-08-01

    We discuss properties of quotient semigroup of abelian semigroup from the viewpoint of *-algebra and apply them to a survey of extension semigroups. Certain interrelations among some equivalence relations of extensions are also considered.

  10. The BGAN extension programme

    Science.gov (United States)

    Rivera, Juan J.; Trachtman, Eyal; Richharia, Madhavendra

    2005-11-01

    Mobile satellite telecommunications systems have undergone an enormous evolution in the last decades, with the interest in having advanced telecommunications services available on demand, anywhere and at any time, leading to incredible advances. The demand for braodband data is therefore rapidly gathering pace, but current solutions are finding it increasingly difficult to combine large bandwidth with ubiquitous coverage, reliability and portability. The BGAN (Broadband Global Area Network) system, designed to operate with the Inmarsat-4 satellites, provides breakthrough services that meet all of these requirements. It will enable broadband connection on the move, delivering all the key tools of the modern office. Recognising the great impact that Inmarsat's BGAN system will have on the European satellite communications industry, and the benefits that it will bring to a wide range of European industries, in 2003 ESA initiated the "BGAN Extension" project. Its primary goals are to provide the full range of BGAN services to truly mobile platforms, operating in aeronautical, vehicular and maritime environments, and to introduce a multicast service capability. The project is supported by the ARTES Programme which establishes a collaboration agreement between ESA, Inmarsat and a group of key industrial and academic institutions which includes EMS, Logica, Nera and the University of Surrey (UK).

  11. Efficacy and safety of switching from reference infliximab to CT-P13 compared with maintenance of CT-P13 in ankylosing spondylitis: 102-week data from the PLANETAS extension study

    Science.gov (United States)

    Park, Won; Yoo, Dae Hyun; Miranda, Pedro; Brzosko, Marek; Wiland, Piotr; Gutierrez-Ureña, Sergio; Mikazane, Helena; Lee, Yeon-Ah; Smiyan, Svitlana; Lim, Mie-Jin; Kadinov, Vladimir; Abud-Mendoza, Carlos; Kim, HoUng; Lee, Sang Joon; Bae, YunJu; Kim, SuYeon; Braun, Jürgen

    2017-01-01

    Objectives To investigate the efficacy and safety of switching from infliximab reference product (RP) to its biosimilar or maintaining biosimilar treatment in patients with ankylosing spondylitis (AS). Methods This open-label extension study recruited patients with AS who completed a 54-week, randomised controlled study comparing CT-P13 with RP (PLANETAS). CT-P13 (5 mg/kg) was administered intravenously every 8 weeks from week 62 to week 102. Efficacy end points included the proportion of patients achieving Assessment of SpondyloArthritis international Society (ASAS)20. Antidrug antibodies (ADAs) were measured using an electrochemiluminescent method. Data were analysed for patients treated with CT-P13 in the main PLANETAS study and the extension (maintenance group) and those who were switched to CT-P13 during the extension study (switch group). Results Overall, 174 (82.9%) of 210 patients who completed the first 54 weeks of PLANETAS and agreed to participate in the extension were enrolled. Among these, 88 were maintained on CT-P13 and 86 were switched to CT-P13 from RP. In these maintenance and switch groups, respectively, ASAS20 response rates at week 102 were 80.7% and 76.9%. ASAS40 and ASAS partial remission were also similar between groups. ADA positivity rates were comparable (week 102: 23.3% vs 27.4%). Adverse events led to treatment discontinuation during the extension study in 3 (3.3%) and 4 (4.8%) patients, respectively. Conclusions This is the first study to show that switching from RP to its biosimilar CT-P13 is possible without negative effects on safety or efficacy in patients with AS. In the maintenance group, CT-P13 was effective and well tolerated over 2 years of treatment. Trial registration number NCT01571206; Results. PMID:27117698

  12. Pegylated interferon in HBeAg-positive and -negative chronic hepatitis B patients: post-treatment 1-year results of three Turkish centres.

    Science.gov (United States)

    Yamazhan, Tansu; Kurtaran, Behice; Pullukçu, Hüsnü; Yüksel, Esma; Özkaya, Deniz; Taşbakan, Meltem Işıkgöz; Sipahi, Oğuz Reşat; Durusoy, Raika; Aksu, Hasan Salih Zeki

    2014-12-01

    In this study, we aimed to evaluate the 1-year post-treatment follow-up results of 112 patients who received pegylated interferon (PEG-IFN) for 52 weeks. HBeAg negativity/seroconversion and/or negative HBV-DNA at the end of the treatment were considered as response. Patients who had response at the end of treatment but had HBV-DNA breakthrough during 1-year follow-up were considered as relapse. The study group comprised 112 cases (34 HBeAg-positive, 78 HBeAg-negative). In HBeAg-positive and -negative cases, end-of-treatment response rates were 2·9% and 60·2%, whereas 1-year sustained virological response rates were 0 and 33·3%, respectively. When we compared relapse cases versus cases with response at the end of 1-year follow-up, being female and having low viral load were the two parameters associated with higher response rates (Chi-square, P  =  0·028; Mann-Whitney U test, P  =  0·023). Overall non-response rates to PEG-IFN were high (57·1%). Results in HBeAg-positive cases were disappointing.

  13. Diet in 1-year-old farm and control children and allergy development: results from the FARMFLORA birth cohort

    Science.gov (United States)

    Jonsson, Karin; Green, My; Barman, Malin; Sjöberg, Agneta; Brekke, Hilde K.; Wold, Agnes E.; Sandberg, Ann-Sofie

    2016-01-01

    Background A farming environment confers strong protection against allergy development. We have previously shown that farming mothers consume more full-fat dairy than control mothers, who instead consume more low-fat dairy, margarine, and oils; margarine and oil intake was associated with increased risk of allergy development in their children. Objectives The aims of this study were to investigate the differences in diet between children in farming and control families at 1 year of age, to investigate the relation between the diets of the mothers and their children, and to relate the children's diet to allergy development. Design The diet of 1-year-old children from dairy farming families (n=28) and from control families in the same rural area (n=37) was assessed by 24-h dietary recalls, followed by 24-h food diaries. Allergy was diagnosed by pediatricians at 3 years of age using strict predefined criteria. Results Farm children had a higher intake of farm milk, whole cream, cholesterol, saturated fat, and fat in total and tended to eat more butter, while controls consumed more carbohydrates and poultry and tended to eat more margarine. Farm children also had higher intakes of homemade porridge/gruel, oily fish, and iodine. The intake of butter and whole milk in children and mothers correlated significantly in farm families but not in controls. A weak negative association was found between seafood intake and allergy development, while allergy was positively associated with the intake of pork as well as zinc in the control group; these intakes also correlated with each other. Conclusions Consistent with mothers in farming families, the children consumed more full-fat dairy and saturated fat than did controls, but this could not be linked to the low risk of allergy in the farming group. Seafood intake might protect against allergy development, in accordance with earlier findings. PMID:27534847

  14. Diet in 1-year-old farm and control children and allergy development: results from the FARMFLORA birth cohort

    Directory of Open Access Journals (Sweden)

    Karin Jonsson

    2016-08-01

    Full Text Available Background: A farming environment confers strong protection against allergy development. We have previously shown that farming mothers consume more full-fat dairy than control mothers, who instead consume more low-fat dairy, margarine, and oils; margarine and oil intake was associated with increased risk of allergy development in their children. Objectives: The aims of this study were to investigate the differences in diet between children in farming and control families at 1 year of age, to investigate the relation between the diets of the mothers and their children, and to relate the children's diet to allergy development. Design: The diet of 1-year-old children from dairy farming families (n=28 and from control families in the same rural area (n=37 was assessed by 24-h dietary recalls, followed by 24-h food diaries. Allergy was diagnosed by pediatricians at 3 years of age using strict predefined criteria. Results: Farm children had a higher intake of farm milk, whole cream, cholesterol, saturated fat, and fat in total and tended to eat more butter, while controls consumed more carbohydrates and poultry and tended to eat more margarine. Farm children also had higher intakes of homemade porridge/gruel, oily fish, and iodine. The intake of butter and whole milk in children and mothers correlated significantly in farm families but not in controls. A weak negative association was found between seafood intake and allergy development, while allergy was positively associated with the intake of pork as well as zinc in the control group; these intakes also correlated with each other. Conclusions: Consistent with mothers in farming families, the children consumed more full-fat dairy and saturated fat than did controls, but this could not be linked to the low risk of allergy in the farming group. Seafood intake might protect against allergy development, in accordance with earlier findings.

  15. Extensions and Pullbacks in QB-rings

    OpenAIRE

    Ara, Pere; Pedersen, Gert K.; Perera, Francesc

    2001-01-01

    We prove a new extension result for $QB-$rings that allows us to examine extensions of rings where the ideal is purely infinite and simple. We then use this result to explore various constructions that provide new examples of $QB-$rings. More concretely, we show that a surjective pullback of two $QB-$rings is usually again a $QB-$ring. Specializing to the case of an extension of a semi-prime ideal $I$ of a unital ring $R$, the pullback setting leads naturally to the study of rings whose multi...

  16. A Classification of BPEL Extensions

    Directory of Open Access Journals (Sweden)

    Oliver Kopp

    2011-10-01

    Full Text Available The Business Process Execution Language (BPEL has emerged as de-facto standard for business processes implementation. This language is designed to be extensible for including additional valuable features in a standardized manner. There are a number of BPEL extensions available. They are, however, neither classified nor evaluated with respect to their compliance to the BPEL standard. This article fills this gap by providing a framework for classifying BPEL extensions, a classification of existing extensions, and a guideline for designing BPEL extensions.

  17. The Study to the Choice of Brand Extension Model and Strategy%论品牌延伸模式与策略的选择

    Institute of Scientific and Technical Information of China (English)

    罗满建

    2011-01-01

    This article introduces and inductive brand extension mode and strategy types and function, demonstrates the mode and strategy selection should rely on conditions, mutual matching nature. Facilitate brand manager guide practical control activities.%文章介绍并归纳品牌延伸模式和策略种类及作用,论证了模式和策略的选择应依赖条件、相互之间的匹配性。便于品牌经营者指导实际的管控活动。

  18. Matrix Extension Study: Validation of the Compact Dry EC Method for Enumeration of Escherichia coli and non-E. coli Coliform Bacteria in Selected Foods.

    Science.gov (United States)

    Mizuochi, Shingo; Nelson, Maria; Baylis, Chris; Green, Becky; Jewell, Keith; Monadjemi, Farinaz; Chen, Yi; Salfinger, Yvonne; Fernandez, Maria Cristina

    2016-01-01

    The Compact Dry "Nissui" EC method, originally certified by the AOAC Research Institute Performance Test Method(SM) program for enumeration of Escherichia coli and non-E. coli coliforms in raw meat products (Performance Tested Method(SM) 110402), has undergone an evaluation to extend the method's claim to cooked chicken, prewashed bagged shredded iceberg lettuce, frozen cod filets, instant nonfat dry milk powder, and pasteurized milk (2% fat). Compact Dry EC is a ready-to-use dry media sheet containing a cold-soluble gelling agent, selective agents, and a chromogenic medium, which are rehydrated by adding 1 mL diluted sample. E. coli form blue/blue-purple colonies, whereas other coliform bacteria form red/pink colonies. Users can obtain an E. coli count (blue/blue-purple colonies only) and a total coliform count (red/pink plus blue/blue-purple colonies) after 24 ± 2 h of incubation at 37 ± 1°C. The matrix extension study was organized by Campden BRI (formerly Campden and Chorleywood Food Research Association Technology, Ltd), Chipping Campden, United Kingdom. Method comparison data for cooked chicken, prewashed bagged shredded iceberg lettuce, frozen cod filets, and instant nonfat dry milk powder were collected in a single-laboratory evaluation by Campden BRI. A multilaboratory study was conducted on pasteurized milk (2% fat), with 13 laboratories participating. The Compact Dry EC method was compared to ISO 16649-2:2001 "Microbiology of food and animal feeding stuffs-Horizontal method for the enumeration of beta-glucuronidase-positive Escherichia coli-Part 2: Colony-count technique at 44 degrees C using 5-bromo-4-chloro-3-indolyl beta-D-glucuronide" and to ISO 4832:2006 "Microbiology of food and animal feeding stuffs-Horizontal method for the enumeration of coliforms-Colony-count technique," the current standards at the time of this study. Each matrix was evaluated separately for E. coli and non-E. coli coliforms at each contamination level (including an

  19. Prognostic role of D-dimer for in-hospital and 1-year mortality in exacerbations of COPD

    Directory of Open Access Journals (Sweden)

    Hu G

    2016-10-01

    Full Text Available Guoping Hu,1 Yankui Wu,2 Yumin Zhou,3 Zelong Wu,1 Liping Wei,1 Yuqun Li,1 GongYong Peng,3 Weiqiang Liang,1 Pixin Ran3 1Department of Respiratory Medicine, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, 2Department of Respiratory Disease of People’s Hospital of Guangxi Zhuang Autonomous Region, Guangxi Zhuang Autonomous Region, 3Guangzhou Institute of Respiratory Disease, State Key Lab of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, People’s Republic of China Background and objective: Serum D-dimer is elevated in respiratory disease. The objective of our study was to investigate the effect of D-dimer on in-hospital and 1-year mortality after acute exacerbations of chronic obstructive pulmonary disease (AECOPD. Methods: Upon admission, we measured 343 AECOPD patients’ serum D-dimer levels and arterial blood gas analysis, and recorded their clinical characteristics. The level of D-dimer that discriminated survivors and non-survivors was determined using a receiver operator curve (ROC. The risk factors for in-hospital mortality were identified through univariate analysis and multiple logistic regression analyses. To evaluate the predictive role of D-dimer for 1-year mortality, univariate and multivariate Cox regression analyses were performed. Results: In all, 28 patients died, and 315 patients survived in the in-hospital period. The group of dead patients had lower pH levels (7.35±0.11 vs 7.39±0.05, P<0.0001, higher D-dimer, arterial carbon dioxide tension (PaCO2, C-reactive protein (CRP, and blood urea nitrogen (BUN levels (D-dimer 2,244.9±2,310.7 vs 768.2±1,078.4 µg/L, P<0.0001; PaCO2: 58.8±29.7 vs 46.1±27.0 mmHg, P=0.018; CRP: 81.5±66, P=0.001; BUN: 10.20±6.87 vs 6.15±3.15 mmol/L, P<0.0001, and lower hemoglobin levels (118.6±29.4 vs 128.3±18.2 g/L, P=0.001. The areas under the ROC curves of D-dimer for in-hospital death were 0

  20. Congenital abnormality of the vagina complicated by haemato-pyocolpos in a 1-year labrador retriever.

    Science.gov (United States)

    Alonge, S; Romussi, S; Grieco, V; Luvoni, G C

    2015-06-01

    A 1-year-old female Labrador retriever was referred with a few days history of haematic-like vulvar discharge. Physical examination, vaginal inspection and palpation did not reveal any remarkable finding. Transabdominal ultrasound showed echogenic fluid accumulation in the vagina suggesting haemato-pyocolpos. An exploratory laparotomy was performed: a well-delimited ectasic vagina was identified. Ovariohysterectomy and partial vaginectomy and vaginoplasty were performed to spay the bitch and to remove the ectasic vagina. Post-operative recovery and 12-month follow-up were uneventful. Clinical, morphological and histological findings were consistent with a congenital abnormality of the muscular layer of the vagina complicated by haemato-pyocolpos. The disorganization of the vaginal tunica muscularis may have acted as locus minoris resistentiae in the vaginal wall. The organ was dilated and atonic due to the gradual accumulation of physiological fluids complicated by an overgrowth of genital bacteria. This congenital disorder has to be taken into account as differential diagnosis of haemato-pyocolpos with vaginal discharge in young bitches.

  1. Depression and posttraumatic stress disorder in temporary settlement residents 1 year after the Sichuan earthquake.

    Science.gov (United States)

    Cheng, Zhang; Ma, Ning; Yang, Lei; Agho, Kingsley; Stevens, Garry; Raphael, Beverley; Cui, Lijun; Liu, Yongqiao; Yan, Baoping; Ma, Hong; Yu, Xin

    2015-03-01

    The authors sought to determine the prevalence and risk factors for major depressive disorder and posttraumatic stress disorder (PTSD) among survivors living in temporary accommodation in the Yongxing settlement in Mianyang city 1 year after the Sichuan earthquake for further interventions. They interviewed 182 residents, using the Structured Clinical Interview for DSM-IV Axis I Disorders and a self-report questionnaire. The 12-month prevalence of depressive disorder and PTSD were 48.9% and 39.6%, respectively. Multivariate analysis indicated that bereaved survivors were 5.51 times (adjusted odds ratio [AOR] = 5.51; 95% confidence interval [CI] =2.14-14.22) more likely to report PTSD and 2.42 times (AOR = 2.42; 95%CI =1.00-5.48) more likely to report depressive disorder than nonbereaved survivors. Older age and receipt of government financial support were significantly associated with 12-month PTSD. Depressive disorder 12 months after the earthquake was associated with receipt of government financial support, pre-earthquake physical illness, single marital status, being currently employed, and Han ethnicity.

  2. Sustained sympathetic and blood pressure reduction 1 year after renal denervation in patients with resistant hypertension.

    Science.gov (United States)

    Hering, Dagmara; Marusic, Petra; Walton, Antony S; Lambert, Elisabeth A; Krum, Henry; Narkiewicz, Krzysztof; Lambert, Gavin W; Esler, Murray D; Schlaich, Markus P

    2014-07-01

    Renal denervation (RDN) reduces muscle sympathetic nerve activity (MSNA) and blood pressure (BP) in resistant hypertension. Although a persistent BP-lowering effect has been demonstrated, the long-term effect on MSNA remains elusive. We investigated whether RDN influences MSNA over time. Office BP and MSNA were obtained at baseline, 3, 6, and 12 months after RDN in 35 patients with resistant hypertension. Office BP averaged 166±22/88±19 mm Hg, despite the use of an average of 4.8±2.1 antihypertensive drugs. Baseline MSNA was 51±11 bursts/min ≈2- to 3-fold higher than the level observed in healthy controls. Mean office systolic and diastolic BP significantly decreased by -12.6±18.3/-6.5±9.2, -16.1±25.6/-8.6±12.9, and -21.2±29.1/-11.1±12.9 mm Hg (Phypertension and high baseline MSNA. These observations are compatible with the hypothesis of a substantial contribution of afferent renal nerve signaling to increased BP in resistant hypertension and argue against a relevant reinnervation at 1 year after procedure.

  3. Beyond Earth: Weaving Science and Indigenous Culture - A 1-year NSF Planning Grant

    Science.gov (United States)

    Young, Timothy; Guy, M.; Baker Big-Back, C.; Froelich, K.

    2011-01-01

    We present results of a 1-year NSF planning grant called Beyond Earth. The project is designed to engage Native American, urban, and rural families in science learning while piloting curriculum development and implementation that incorporates both Native and Western epistemologies. Physical, earth, and space science content is juxtaposed with indigenous culture, stories, language and epistemology in after-school programs and teacher training. Project partners include the Dakota Science Center, Fort Berthold Community College, and Sitting Bull College. The Native American tribes represented in this initiative illustrate partnerships between the Dakota, Lakota, Nakota, Hidatsa, Mandan, and Arikara. Over the past year the primary project deliverables include a culturally responsive curriculum Beyond Earth Moon Module, teacher training workshops, a project website. The curriculum module introduces students to the moon's appearance, phases, and positions in the sky using the Night Sky Planetarium Experience Station to explore core concepts underlying moon phases and eclipses using the interactive Nature Experience Station before engaging in the culminating Mission Challenge in which they apply their knowledge to problem solving situations and projects. The Native Science and Western Science activities developed, planetarium explorations created, and website toolkit utilizations are presented.

  4. Ablation for atrial fibrillation during mitral valve surgery: 1-year results through continuous subcutaneous monitoring†

    Science.gov (United States)

    Bogachev-Prokophiev, Alexandr; Zheleznev, Sergey; Romanov, Alexander; Pokushalov, Evgeny; Pivkin, Alexey; Corbucci, Giorgio; Karaskov, Alexander

    2012-01-01

    Continuous monitoring of cardiac rhythm may play an important role in measuring the true symptomatic/asymptomatic atrial fibrillation (AF) burden and improve the management of anti-arrhythmic and anti-thrombotic therapies. Forty-seven patients with mitral valve disease and longstanding persistent AF (LSPAF) underwent a left atrial maze procedure with bipolar radiofrequency and valve surgery. The follow-up data recorded by an implanted loop recorder were analysed after 3, 6 and 12 months. On discharge, 40 (85.1%) patients were in stable sinus rhythm, as documented by in-office electrocardiography (ECG), 4 (8.5%) were in pacemaker rhythm and 3 (6.4%) were in AF. One (2.1%) patient died after 7 months. On 12-month follow-up examination, 30 (65.2%) patients had an AF burden 0.5%. Two (4.3%) patients with AF recurrences were completely asymptomatic. Among the symptomatic events stored by the patients, only 27.6% was confirmed as genuine AF recurrences according to the concomitant ECG recorded by the implanted loop recorder. A concomitant bipolar maze procedure during mitral valve surgery is effective in treating AF, as proved by detailed 1-year continuous monitoring. PMID:22514258

  5. Ablation for atrial fibrillation during mitral valve surgery: 1-year results through continuous subcutaneous monitoring.

    Science.gov (United States)

    Bogachev-Prokophiev, Alexandr; Zheleznev, Sergey; Romanov, Alexander; Pokushalov, Evgeny; Pivkin, Alexey; Corbucci, Giorgio; Karaskov, Alexander

    2012-07-01

    Continuous monitoring of cardiac rhythm may play an important role in measuring the true symptomatic/asymptomatic atrial fibrillation (AF) burden and improve the management of anti-arrhythmic and anti-thrombotic therapies. Forty-seven patients with mitral valve disease and longstanding persistent AF (LSPAF) underwent a left atrial maze procedure with bipolar radiofrequency and valve surgery. The follow-up data recorded by an implanted loop recorder were analysed after 3, 6 and 12 months. On discharge, 40 (85.1%) patients were in stable sinus rhythm, as documented by in-office electrocardiography (ECG), 4 (8.5%) were in pacemaker rhythm and 3 (6.4%) were in AF. One (2.1%) patient died after 7 months. On 12-month follow-up examination, 30 (65.2%) patients had an AF burden 0.5%. Two (4.3%) patients with AF recurrences were completely asymptomatic. Among the symptomatic events stored by the patients, only 27.6% was confirmed as genuine AF recurrences according to the concomitant ECG recorded by the implanted loop recorder. A concomitant bipolar maze procedure during mitral valve surgery is effective in treating AF, as proved by detailed 1-year continuous monitoring.

  6. Results of 1 year of clinical experience with independent dose calculation software for VMAT fields

    Directory of Open Access Journals (Sweden)

    Juan Fernando Mata Colodro

    2014-01-01

    Full Text Available It is widely accepted that a redundant independent dose calculation (RIDC must be included in any treatment planning verification procedure. Specifically, volumetric modulated arc therapy (VMAT technique implies a comprehensive quality assurance (QA program in which RIDC should be included. In this paper, the results obtained in 1 year of clinical experience are presented. Eclipse from Varian is the treatment planning system (TPS, here in use. RIDC were performed with the commercial software; Diamond ® (PTW which is capable of calculating VMAT fields. Once the plan is clinically accepted, it is exported via Digital Imaging and Communications in Medicine (DICOM to RIDC, together with the body contour, and then a point dose calculation is performed, usually at the isocenter. A total of 459 plans were evaluated. The total average deviation was -0.3 ± 1.8% (one standard deviation (1SD. For higher clearance the plans were grouped by location in: Prostate, pelvis, abdomen, chest, head and neck, brain, stereotactic radiosurgery, lung stereotactic body radiation therapy, and miscellaneous. The highest absolute deviation was -0.8 ± 1.5% corresponding to the prostate. A linear fit between doses calculated by RIDC and by TPS produced a correlation coefficient of 0.9991 and a slope of 1.0023. These results are very close to those obtained in the validation process. This agreement led us to consider this RIDC software as a valuable tool for QA in VMAT plans.

  7. Results of 1 year of clinical experience with independent dose calculation software for VMAT fields.

    Science.gov (United States)

    Colodro, Juan Fernando Mata; Berna, Alfredo Serna; Puchades, Vicente Puchades; Amores, David Ramos; Baños, Miguel Alcaraz

    2014-10-01

    It is widely accepted that a redundant independent dose calculation (RIDC) must be included in any treatment planning verification procedure. Specifically, volumetric modulated arc therapy (VMAT) technique implies a comprehensive quality assurance (QA) program in which RIDC should be included. In this paper, the results obtained in 1 year of clinical experience are presented. Eclipse from Varian is the treatment planning system (TPS), here in use. RIDC were performed with the commercial software; Diamond(®) (PTW) which is capable of calculating VMAT fields. Once the plan is clinically accepted, it is exported via Digital Imaging and Communications in Medicine (DICOM) to RIDC, together with the body contour, and then a point dose calculation is performed, usually at the isocenter. A total of 459 plans were evaluated. The total average deviation was -0.3 ± 1.8% (one standard deviation (1SD)). For higher clearance the plans were grouped by location in: Prostate, pelvis, abdomen, chest, head and neck, brain, stereotactic radiosurgery, lung stereotactic body radiation therapy, and miscellaneous. The highest absolute deviation was -0.8 ± 1.5% corresponding to the prostate. A linear fit between doses calculated by RIDC and by TPS produced a correlation coefficient of 0.9991 and a slope of 1.0023. These results are very close to those obtained in the validation process. This agreement led us to consider this RIDC software as a valuable tool for QA in VMAT plans.

  8. A 1-year-old boy with persistent, generalized eruption. Urticaria pigmentosa.

    Science.gov (United States)

    Mir, Adnan; Chamlin, Sarah L

    2014-01-01

    A healthy 1-year-old boy born at full term after an uncomplicated pregnancy presented to the dermatology clinic for a widespread eruption with gradual onset since 3 months of age. He was otherwise well, afebrile, feeding well, and gaining weight appropriately. The child was overall asymptomatic, though some of his lesions occasionally became red and pruritic. His mother noticed that after mild illnesses, he was more prone to these flares. She denied flushing, vomiting, diarrhea, respiratory distress, and irritability. He was meeting all developmental milestones and started walking at 11 months of age. The remainder of his review of systems was unremarkable, and family history was noncontributory. Physical exam revealed a well-appearing, well-nourished, playful, and interactive toddler. There were innumerable discrete and coalescing pink-brown macules and papules concentrated on the trunk and extending onto the proximal upper and lower extremities bilaterally, as well as the neck and lower face. Stroking the lesions quickly led to development of erythematous edematous wheals. There was no hepatosplenomegaly, and the lymph node exam was unremarkable.

  9. 泛耐药结核病的研究现状%Advance in study of extensively drip-resistant tuberculosis

    Institute of Scientific and Technical Information of China (English)

    李坚

    2008-01-01

    泛耐药结核病(extensively drug-resistant tuberculosiss,XDR-TB)是结核病患者感染的结核分枝杆菌对利福平和异烟肼耐药,同时对任何一个氟喹诺酮类药物耐药,以及至少对卷曲霉素、卡那霉素和阿米卡星中的一个耐药.XDR-TB的出现将使人类结核病控制面临新威胁和新挑战.本文对XDR-TB的定义、流行病学研究、临床特点和防控措施的研究现状进行综述.%Extensively drug-resistant tuberculosis(XDR-TB) is caused by a strain of Mycobaeterium tuberculosis resistant to isoniazid and rifampin (which defines multi-drug resistant tuberculosis) in addition to any fluoroquinolone and at least one of the three following injectable drugs: capreomycin, kanamyein,and amikacin. The appearance of XDR-TB has made control o~ human tuberculosis challenging in global. This article reviews definition,epidemiology,clinical feature and prevention and control of tuberculosis.

  10. STUDY ABOUT ROLE EXTENSION DESIGN OF PACKAGING CONTAINER%儿童食品包装容器的角色延展设计研究

    Institute of Scientific and Technical Information of China (English)

    严敏

    2015-01-01

    包装容器的角色延展设计是对于绿色设计理念新思路的探索。儿童食品消费群体的多元化,对其包装提出了更高的要求。本文从收纳容器、智力手工玩具,学习用具三个方面探讨儿童食品包装容器角色延展方向。通过外观造型、结构改造、图文添加等几个方面挖掘儿童包装的新意向,达到包装与人互动,包装融入生活的目的。%Role extension design of packaging container is to explore new idea of green design concept. Diversification of children's food consumption groups put forward higher requirements to their packaging. This article probe role extension directions of children's food packaging containers by container, intel igence handmade toys, and school supplies. Looking for new function of children packaging by appearance, structural reform, and adding graphics, is to achieve purpose of packaging interact with people, and integrate into life.

  11. Baseline status and dose to the penile bulb predict impotence 1 year after radiotherapy for prostate cancer

    Energy Technology Data Exchange (ETDEWEB)

    Cozzarini, Cesare; Badenchini, Fabio [San Raffaele Scientific Institute, Radiotherapy, Milano (Italy); Rancati, Tiziana [Fondazione IRCCS Istituto Nazionale dei Tumori, Prostate Cancer Program, Milan (Italy); Palorini, Federica; Improta, Ilaria; Fiorino, Claudio [San Raffaele Scientific Institute, Medical Physics, Milan (Italy); Avuzzi, Barbara [Fondazione IRCCS Istituto Nazionale dei Tumori, Radiation Oncology 1, Milan (Italy); Degli Esposti, Claudio [Ospedale Bellaria, Radiotherapy, Bologna (Italy); Girelli, Giuseppe [Ospedale ASL9, Radiotherapy, Ivrea (Italy); Vavassori, Vittorio [Cliniche Gavazzeni-Humanitas, Radiotherapy, Bergamo (Italy); Valdagni, Riccardo [Fondazione IRCCS Istituto Nazionale dei Tumori, Prostate Cancer Program, Milan (Italy); Fondazione IRCCS Istituto Nazionale dei Tumori, Radiation Oncology 1, Milan (Italy)

    2016-05-15

    To assess the predictors of the onset of impotence 1 year after radiotherapy for prostate cancer. In a multi-centric prospective study, the International Index of Erectile Function (IIEF) questionnaire-based potency of 91 hormone-naive and potent patients (IIEF1-5 > 11 before radiotherapy) was assessed. At the time of this analysis, information on potency 1 year after treatment was available for 62 of 91 patients (42 treated with hypofractionation: 2.35-2.65 Gy/fr, 70-74.2 Gy; 20 with conventional fractionation: 74-78 Gy). Prospectively collected individual information and D{sub max}/D{sub mean} to the penile bulb were available; the corresponding 2 Gy-equivalent values (EQD2 {sub max}/EQD2 {sub mean}) were also considered. Predictors of 1-year impotency were assessed through uni- and multi-variable backward logistic regression: The best cut-off values discriminating between potent and impotent patients were assessed by ROC analyses. The discriminative power of the models and goodness-of-fit were measured by AUC analysis and the Hosmer-Lemeshow (H and L) test. At 1-year follow-up, 26 of 62 patients (42 %) became impotent. The only predictive variables were baseline IIEF1-5 values (best cut-off baseline IIEF1-5 ≥ 19), D{sub max} ≥ 68.5 Gy and EQD2 {sub max} ≥ 74.2 Gy. The risk of 1-year impotence may be predicted by a two-variable model including baseline IIEF1-5 (OR: 0.80, p = 0.003) and EQD2 {sub max} ≥ 74.2 Gy (OR: 4.1, p = 0.022). The AUC of the model was 0.77 (95% CI: 0.64-0.87, p = 0.0007, H and L: p = 0.62). The 1-year risk of impotency after high-dose radiotherapy in potent men depends on the EQD2 {sub max} to the penile bulb and on baseline IIEF1-5 values. A significant reduction in the risk may be expected mainly when sparing the bulb in patients with no/mild baseline impotency (IIEF1-5 > 17). (orig.) [German] Beurteilung von Praediktoren fuer das Auftreten von Impotenz 1 Jahr nach Radiotherapie bei Prostatakrebs. In einer multizentrischen

  12. Selfadjoint extensions of multipoint singular differential operators

    Directory of Open Access Journals (Sweden)

    Zameddin I. Ismailov

    2013-10-01

    Full Text Available This article describes all selfadjoint extensions of the minimal operator generated by a linear singular multipoint symmetric differential-operator expression for first order in the direct sum of Hilbert spaces of vector-functions. This description is done in terms of the boundary values, and it uses the Everitt-Zettl and the Calkin-Gorbachuk methods. Also the structure of the spectrum of these extensions is studied.

  13. Effect of 1 year of discontinuation of raloxifene or estrogen therapy on bone mineral density after 5 years of treatment in healthy postmenopausal women.

    Science.gov (United States)

    Neele, S J M; Evertz, R; De Valk-De Roo, G; Roos, J C; Netelenbos, J C

    2002-04-01

    The beneficial effects of hormone replacement therapy (HRT), selective estrogen receptor modulators (SERMs), or bisphosphonates in the prevention and treatment of osteoporosis in postmenopausal women have been well established. However, little is known about the effects of discontinuation of treatment on bone mineral density. We investigated the effect of 1 year of discontinuation of the SERM raloxifene (Ral; 60 mg and 150 mg), conjugated equine estrogen (CEE; 0.625 mg), and placebo after 5 years of treatment in a double-blind, randomized study. Thirty-eight of 59 healthy and hysterectomized postmenopausal women (mean age 55 years) completed the treatment and 1 year follow-up period. Lumbar spine and femoral neck bone mineral density (BMD) were performed with dual-energy X-ray absorptiometry, before, during, and at the end of treatment, as well as after 1 year of discontinuation of therapy. One year of discontinuation significantly reduced the mean lumbar spine BMD in the raloxifene- and estrogen-treated women (p protect against bone loss after 1 year of withdrawal of therapy, and that the rate of bone loss was not significantly different from that of placebo-treated women.

  14. Comparison of weight loss outcomes 1 year after sleeve gastrectomy and Roux-en-Y gastric bypass in patients aged above 50 years

    Directory of Open Access Journals (Sweden)

    Palanivelu Praveenraj

    2016-01-01

    Full Text Available Introduction: Safe, effective weight loss with resolution of comorbidities has been convincingly demonstrated with bariatric surgery in the aged obese. They, however, lose less weight than younger individuals. It is not known if degree of weight loss is influenced by the choice of bariatric procedure. The aim of this study was to compare the degree of weight loss between laparoscopic sleeve gastrectomy (LSG and laparoscopic Roux-en-Y gastric bypass (LRYGB in patients above the age of 50 years at 1 year after surgery. Materials and Methods: A retrospective analysis was performed of all patients more than 50 years of age who underwent LSG or LRYGB between February 2012 and July 2013 with at least 1 year of follow-up. Data evaluated at 1 year included age, sex, weight, body mass index (BMI, mean operative time, percentage of weight loss and excess weight loss, resolution/remission of diabetes, morbidity and mortality. Results: Of a total of 86 patients, 54 underwent LSG and 32 underwent LRYGB. The mean percentage of excess weight loss at the end of 1 year was 60.19 ± 17.45 % after LSG and 82.76 ± 34.26 % after LRYGB (P = 0.021. One patient developed a sleeve leak after LSG, and 2 developed iron deficiency anaemia after LRYGB. The remission/improvement in diabetes mellitus and biochemistry was similar. Conclusion: LRYGB may offer better results than LSG in terms of weight loss in patients over 50 years of age.

  15. Comparison of weight loss outcomes 1 year after sleeve gastrectomy and Roux-en-Y gastric bypass in patients aged above 50 years

    Science.gov (United States)

    Praveenraj, Palanivelu; Gomes, Rachel M; Kumar, Saravana; Perumal, Sivalingam; Senthilnathan, Palanisamy; Parthasarathi, Ramakrishnan; Rajapandian, Subbiah; Palanivelu, Chinnusamy

    2016-01-01

    INTRODUCTION: Safe, effective weight loss with resolution of comorbidities has been convincingly demonstrated with bariatric surgery in the aged obese. They, however, lose less weight than younger individuals. It is not known if degree of weight loss is influenced by the choice of bariatric procedure. The aim of this study was to compare the degree of weight loss between laparoscopic sleeve gastrectomy (LSG) and laparoscopic Roux-en-Y gastric bypass (LRYGB) in patients above the age of 50 years at 1 year after surgery. MATERIALS AND METHODS: A retrospective analysis was performed of all patients more than 50 years of age who underwent LSG or LRYGB between February 2012 and July 2013 with at least 1 year of follow-up. Data evaluated at 1 year included age, sex, weight, body mass index (BMI), mean operative time, percentage of weight loss and excess weight loss, resolution/remission of diabetes, morbidity and mortality. RESULTS: Of a total of 86 patients, 54 underwent LSG and 32 underwent LRYGB. The mean percentage of excess weight loss at the end of 1 year was 60.19 ± 17.45 % after LSG and 82.76 ± 34.26 % after LRYGB (P = 0.021). One patient developed a sleeve leak after LSG, and 2 developed iron deficiency anaemia after LRYGB. The remission/improvement in diabetes mellitus and biochemistry was similar. CONCLUSION: LRYGB may offer better results than LSG in terms of weight loss in patients over 50 years of age. PMID:27279392

  16. On non-extensive nature of thermal conductivity

    Indian Academy of Sciences (India)

    Ashok Razdan

    2007-01-01

    In this paper we study non-extensive nature of thermal conductivity. It is observed that there is similarity between non-extensive entropic index and fractal dimension obtained for the silica aerogel thermal conductivity data at low temperature.

  17. Treatment of proximal superficial caries lesions on primary molar teeth with resin infiltration and fluoride varnish versus fluoride varnish only: efficacy after 1 year

    DEFF Research Database (Denmark)

    Ekstrand, K R; Bakhshandeh, A; Martignon, S

    2010-01-01

    This split-mouth study aimed to assess the efficacy of resin-infiltrated lesions covered by fluoride varnish (FV) versus FV treatment only of proximal lesions on deciduous molar teeth. The study lasted for 1 year. Children with 2 or more superficial proximal lesions on deciduous molar teeth.......01). Radiographically, 23% of the test lesions and 62% of the control lesions had progressed (p 35% and significant. To conclude, resin infiltration in conjunction with fluoride varnish seems promising...

  18. An investigation of mass composition of ultra-high energy cosmic rays with energies above 1019 eV via the study of extensive air showers

    Directory of Open Access Journals (Sweden)

    Doostmohammadi S.

    2012-01-01

    Full Text Available The electron and muon components of extensive air shower (EAS with energies above 1019 eV are analyzed via various giant EAS arrays. A varying property of showers is observed for two energy ranges; higher and lower than (3 − 4 x 1019 eV. The age parameter, zenith angle, shower size dependence on muon size and shower size dependence on primary energy show an increment of mass composition (MC above (3−4x 1019eV. Comparison of the observed EAS results with the simulations of Capdevielle et al. (2000 and Shinozaki et al. (2005 gives at most 20% photon fraction for primary energies above 1019 eV. The arrival directions of showers above 4x1019 eV indicate an increasing concentration towards the super galactic plane.

  19. Robot-assisted laparoscopic pyeloplasty: minimum 1-year follow-up

    Science.gov (United States)

    Patel, Vipul; Thaly, Rahul; Shah, Ketul

    2007-02-01

    Objectives: To evaluate the feasibility and efficacy of robotic-assisted laparoscopic pyeloplasty. Laparoscopic pyeloplasty has been shown to have a success rate comparable to that of the open surgical approach. However, the steep learning curve has hindered its acceptance into mainstream urologic practice. The introduction of robotic assistance provides advantages that have the potential to facilitate precise dissection and intracorporeal suturing. Methods: A total of 50 patients underwent robotic-assisted laparoscopic dismembered pyeloplasty. A four-trocar technique was used. Most patients were discharged home on day 1, with stent removal at 3 weeks. Patency of the ureteropelvic junction was assessed in all patients with mercaptotriglycylglycine Lasix renograms at 1, 3, 6, 9, and 12 months, then every 6 months for 1 year, and then yearly. Results: Each patient underwent a successful procedure without open conversion or transfusion. The average estimated blood loss was 40 ml. The operative time averaged 122 minutes (range 60 to 330) overall. Crossing vessels were present in 30% of the patients and were preserved in all cases. The time for the anastomosis averaged 20 minutes (range 10 to 100). Intraoperatively, no complications occurred. Postoperatively, the average hospital stay was 1.1 days. The stents were removed at an average of 20 days (range 14 to 28) postoperatively. The average follow-up was 11.7 months; at the last follow-up visit, each patient was doing well. Of the 50 patients, 48 underwent one or more renograms, demonstrating stable renal function, improved drainage, and no evidence of recurrent obstruction. Conclusions: Robotic-assisted laparoscopic pyeloplasty is a feasible technique for ureteropelvic junction reconstruction. The procedure provides a minimally invasive alternative with good short-term results.

  20. Aerosol source apportionment from 1-year measurements at the CESAR tower in Cabauw, the Netherlands

    Science.gov (United States)

    Schlag, Patrick; Kiendler-Scharr, Astrid; Blom, Marcus Johannes; Canonaco, Francesco; Sebastiaan Henzing, Jeroen; Moerman, Marcel; Prévôt, André Stephan Henry; Holzinger, Rupert

    2016-07-01

    Intensive measurements of submicron aerosol particles and their chemical composition were performed with an Aerosol Chemical Speciation Monitor (ACSM) at the Cabauw Experimental Site for Atmospheric Research (CESAR) in Cabauw, the Netherlands, sampling at 5 m height above ground. The campaign lasted nearly 1 year from July 2012 to June 2013 as part of the EU-FP7-ACTRIS project (Q-ACSM Network). Including equivalent black carbon an average particulate mass concentration of 9.50 µg m-3 was obtained during the whole campaign with dominant contributions from ammonium nitrate (45 %), organic aerosol (OA, 29 %), and ammonium sulfate (19 %). There were 12 exceedances of the World Health Organization (WHO) PM2.5 daily mean limit (25 µg m-3) observed at this rural site using PM1 instrumentation only. Ammonium nitrate and OA represented the largest contributors to total particulate matter during periods of exceedance. Source apportionment of OA was performed season-wise by positive matrix factorization (PMF) using the multilinear engine 2 (ME-2) controlled via the source finder (SoFi). Primary organic aerosols were attributed mainly to traffic (8-16 % contribution to total OA, averaged season-wise) and biomass burning (0-23 %). Secondary organic aerosols (SOAs, 61-84 %) dominated the organic fraction during the whole campaign, particularly on days with high mass loadings. A SOA factor which is attributed to humic-like substances (HULIS) was identified as a highly oxidized background aerosol in Cabauw. This shows the importance of atmospheric aging processes for aerosol concentration at this rural site. Due to the large secondary fraction, the reduction of particulate mass at this rural site is challenging on a local scale.

  1. Effect of ethnicity on weight loss among adolescents 1 year after bariatric surgery

    Institute of Scientific and Technical Information of China (English)

    Sarah; E; Messiah; Gabriela; Lopez-Mitnik; Deborah; Winegar; Bintu; Sherif; Kristopher; L; Arheart; Kirk; W; Reichard; Marc; P; Michalsky; Steven; E; Lipshultz; Tracie; L; Miller; Alan; S; Livingstone; Nestor; de; la; Cruz-Muoz

    2013-01-01

    AIM:To investigate whether or not bariatric surgeryweight outcomes vary by ethnicity in a large,nationally representative sample of adolescents.METHODS:The Bariatric Outcomes Longitudinal Database was used for analysis and contains data on surgeries performed on adolescents from 2004 to 2010from 423 surgeons at 360 facilities across the United States Adolescents(n=827)between 11 and 19 years old who underwent either gastric bypass or adjustable gastric banding surgery were included in the analysis.Outcome measures included changes in anthropometric measurements[weight(kg)and body mass index]from baseline to 3(n=739),6(n=512),and 12(n=247)mo after surgery.RESULTS:A year after patients underwent either gastric bypass(51%)or adjustable gastric banding(49%)surgery,mean estimated weight loss for all ethnic groups differed by a maximum of only 1.5 kg,being34.3 kg(95%CI:30.0-38.5 kg)for Hispanics,33.8 kg(95%CI:27.3-40.3 kg)for non-Hispanic blacks,and32.8 kg(95%CI:30.9-34.7 kg)for non-Hispanic whites.No overall pairwise group comparisons were significant,indicating that no ethnic group had better weight loss outcomes than did another.CONCLUSION:Bariatric surgery substantially reduces the weight of severely obese adolescents at 1 year post-procedure with little variation by ethnicity and/or gender.These results suggest that bariatric surgery is a safe and reasonable treatment for all severely obese adolescents with the appropriate indications.

  2. Change in Metabolic Profile after 1-Year Nutritional-Behavioral Intervention in Obese Children

    Directory of Open Access Journals (Sweden)

    Elvira Verduci

    2015-12-01

    Full Text Available Research findings are inconsistent about improvement of specific cardio-metabolic variables after lifestyle intervention in obese children. The aim of this trial was to evaluate the effect of a 1-year intervention, based on normocaloric diet and physical activity, on body mass index (BMI, blood lipid profile, glucose metabolism and metabolic syndrome. Eighty-five obese children aged ≥6 years were analyzed. The BMI z-score was calculated. Fasting blood samples were analyzed for lipids, insulin and glucose. The homeostatic model assessment of insulin resistance (HOMA-IR was calculated and insulin resistance was defined as HOMA-IR >3.16. HOMA-β%, quantitative insulin sensitivity check index and triglyceride glucose index were calculated. The metabolic syndrome was defined in accordance with the International Diabetes Federation criteria. At the end of intervention children showed a reduction (mean (95% CI in BMI z-score (−0.58 (−0.66; −0.50, triglycerides (−0.35 (−0.45; −0.25 mmol/L and triglyceride glucose index (−0.29 (−0.37; −0.21, and an increase in HDL cholesterol (0.06 (0.01; 0.11 mmol/L. Prevalence of insulin resistance declined from 51.8% to 36.5% and prevalence of metabolic syndrome from 17.1% to 4.9%. Nutritional-behavioral interventions can improve the blood lipid profile and insulin sensitivity in obese children, and possibly provide benefits in terms of metabolic syndrome.

  3. 大面积烧伤延迟复苏效果探讨%Study on the Effect of Delayed Resuscitation in Extensive Burn Patients

    Institute of Scientific and Technical Information of China (English)

    张宏; 林国安

    2014-01-01

    Objective To explore the means and efficacy of delayed resuscitation in patients with extensive burns. Method The fluid resuscitation plan for shock stage of burns provided by the 107th Hospital of PLA (hereinafter referred to as 107 Resuscitation Plan) was adopted as the resuscitation treatment in 25 patients with extensive burns and at delayed admission, and the efficacy was observed. Result Twenty three patients were all healed and discharged, two patients died from multi-organ failure 6 days and 34 days after injury respectively. Conclusion The 107 Resuscitation Plan can help es-timate the accumulated loss of fluid and transfusion speed. It can be used in patients who were at shock stage and delayed to be hospitalized.%目的:探讨大面积烧伤患者延迟复苏的方法及其疗效。方法采用中国人民解放军第107医院提出的烧伤休克期液体复苏方案(下称“107复苏方案”)对25例延迟入院的大面积烧伤患者进行复苏治疗,观察治疗效果。结果23例患者痊愈出院,2例患者分别于伤后第6天和第34天死于多器官功能衰竭。结论107复苏方案能够预估累积丢失量和输液速度,可用于延迟入院治疗的烧伤休克期患者。

  4. Selective contribution of each hamstring muscle to anterior cruciate ligament protection and tibiofemoral joint stability in leg-extension exercise: a simulation study.

    Science.gov (United States)

    Biscarini, Andrea; Botti, Fabio Massimo; Pettorossi, Vito Enrico

    2013-09-01

    A biomechanical model was developed to simulate the selective effect of the co-contraction force provided by each hamstring muscle on the shear and compressive tibiofemoral joint reaction forces, during open kinetic-chain knee-extension exercises. This model accounts for instantaneous values of knee flexion angle [Formula: see text], angular velocity and acceleration, and for changes in magnitude, orientation, and application point of external resistance. The tibiofemoral shear force (TFSF) largely determines the tensile force on anterior cruciate ligament (ACL) and posterior cruciate ligament (PCL). Biceps femoris is the most effective hamstring muscle in decreasing the ACL-loading TFSF developed by quadriceps contractions for [Formula: see text]. In this range, the semimembranosus generates the dominant tibiofemoral compressive force, which enhances joint stability, opposes anterior/posterior tibial translations, and protects cruciate ligaments. The semitendinosus force provides the greatest decreasing gradient of ACL-loading TFSF for [Formula: see text], and the greatest increasing gradient of tibiofemoral compressive force for [Formula: see text]. However, semitendinosus efficacy is strongly limited by its small physiological section. Hamstring muscles behave as a unique muscle in enhancing the PCL-loading TFSF produced by quadriceps contractions for [Formula: see text]. The levels of hamstrings co-activation that suppress the ACL-loading TFSF considerably shift when the knee angular acceleration is changed while maintaining the same level of knee extensor torque by a concurrent adjustment in the magnitude of external resistance. The knowledge of the specific role and the optimal activation level of each hamstring muscle in ACL protection and tibiofemoral stability are fundamental for planning safe and effective rehabilitative knee-extension exercises.

  5. Use of automated external defibrillators in a Brazilian airline. A 1-year experience

    Directory of Open Access Journals (Sweden)

    Alves Paulo Magalhães

    2001-01-01

    Full Text Available After the incorporation of automated external defibrilators by other airlines and the support of the Brazilian Society of cardiology, Varig Airlines Began the onboard defibrilation program with the initial purpose of equiping wide-body aircrafts frequently used in international flights and that airplanes use in the Rio - São Paulo route. With all fight attendants trained, the automated. External defibrilation devides were incorporated to 34 airplanes of a total pleet of 80 aircrats. The devices were intalled in the bagage compartments secured with velero straps and 2 pairs of electrods, one or which pre-conected to the device to minimize application time. Later, a portable monitor was addres to the ressocitation kit in the long flights. The expansion of the knowledge of the basic life support fundamentors and the correted implantation of the survival chain and of the automated external defibrilators will increase the extense of recovery of cardiorespiratory arrest victins in aircrafts.

  6. Grip strength measurements at two different wrist extension positions in chronic lateral epicondylitis-comparison of involved vs. uninvolved side in athletes and non athletes: a case-control study

    Directory of Open Access Journals (Sweden)

    Bhargava Arti S

    2010-09-01

    Full Text Available Abstract Background Lateral epicondylitis is a common sports injury of the elbow caused due to altered muscle activation during repetitive wrist extension in many athletic and non-athletic endeavours. The amount of muscle activity and timing of contraction eventually is directly dependent upon joint position during the activity. The purpose of our study was to compare the grip strength in athletes with lateral epicondylalgia in two different wrist extension positions and compare them between involved and uninvolved sides of athletes and non-athletes. Methods An assessor-blinded case-control study of eight athletes and twenty-two non-athletes was done. The grip strength was measured using JAMAR® hand dynamometer in kilograms-force at 15 degrees (slightly extended and 35 degrees (moderately extended wrist extension positions (maintained by wrist splints on both involved and uninvolved sides of athletes and non-athletes with unilateral lateral epicondylitis of atleast 3 months duration. Their pain was to be elicited with local tenderness and two of three tests being positive- Cozen's, Mill's manoeuvre, resisted middle finger extension tests. For comparisons of grip strength, Wilcoxon signed rank test was used for within-group comparison (between 15 and 35 degrees wrist extension positions and Mann-Whitney U test was used for between-group (athletes vs. non-athletes comparisons at 95% confidence interval and were done using SPSS 11.5 for Windows. Results Statistically significant greater grip strength was found in 15 degrees (27.75 ± 4.2 kgms in athletes; 16.45 ± 4.2 kgms in non-athletes wrist extension than at 35 degrees (25.25 ± 3.53 kgm in athletes and 14.18 ± 3.53 kgm in non-athletes. The athletes had greater grip strength than non-athletes in each of test positions (11.3 kgm at 15 degrees and 11.07 kgm at 35 degrees measured. There was also a significant difference between involved and uninvolved sides' grip strength at both wrist

  7. Neuropsychological performance of a patient suspected of dementia taking lorazepam and retested 1 year later following titration.

    Science.gov (United States)

    Scott, Bonnie M; Schmitt, Andrew L; Livingston, Ronald B

    2016-01-01

    The effects of medication on neuropsychological performance have yet to be fully investigated, particularly in older patients. As such, the present case study was undertaken to examine the specific impact of benzodiazepine use on neuropsychological performance by providing a comparison of the test-retest data of an 81-year-old patient taking lorazepam. A comprehensive neuropsychological evaluation was conducted: (a) during the initial referral, while the patient had been taking high doses of lorazepam for approximately 3 years; and (b) 6 months after complete titration, which was 1 year after the initial evaluation. Normative scores derived from the 2 trials were compared via calculation of Reliable Change Indexes. Neuropsychological performance during both evaluations was indicative of dementia, including similar degrees of impairment in delayed memory, verbal fluency, and olfaction. However, scores obtained during the second evaluation were somewhat higher, with significant improvements observed in immediate memory, visuospatial/construction abilities, language function, abstract concept formation, and set shifting. Results of the current case study suggest that several neuropsychological domains may be particularly sensitive to chronic benzodiazepine use. Although the overall diagnostic picture in the present study remained unaltered, clinicians should be cognizant of such medication effects and the potential for these neuropsychological alterations to obscure differential diagnosis.

  8. Nonalcoholic fatty liver disease and increased risk of 1-year all-cause and cardiac hospital readmissions in elderly patients admitted for acute heart failure

    Science.gov (United States)

    Valbusa, Filippo; Bonapace, Stefano; Agnoletti, Davide; Scala, Luca; Grillo, Cristina; Arduini, Pietro; Turcato, Emanuela; Mantovani, Alessandro; Zoppini, Giacomo; Arcaro, Guido; Byrne, Christopher; Targher, Giovanni

    2017-01-01

    Nonalcoholic fatty liver disease (NAFLD) is an emerging risk factor for heart failure (HF). Although some progress has been made in improving survival among patients admitted for HF, the rates of hospital readmissions and the related costs continue to rise dramatically. We sought to examine whether NAFLD and its severity (diagnosed at hospital admission) was independently associated with a higher risk of 1-year all-cause and cardiac re-hospitalization in patients admitted for acute HF. We studied 212 elderly patients who were consecutively admitted with acute HF to the Hospital of Negrar (Verona) over a 1-year period. Diagnosis of NAFLD was based on ultrasonography, whereas the severity of advanced NAFLD fibrosis was based on the fibrosis (FIB)-4 score and other non-invasive fibrosis scores. Patients with acute myocardial infarction, severe valvular heart diseases, end-stage renal disease, cancer, known liver diseases or decompensated cirrhosis were excluded. Cox regression was used to estimate hazard ratios (HR) for the associations between NAFLD and the outcome(s) of interest. The cumulative rate of 1-year all-cause re-hospitalizations was 46.7% (n = 99, mainly due to cardiac causes). Patients with NAFLD (n = 109; 51.4%) had remarkably higher 1-year all-cause and cardiac re-hospitalization rates compared with their counterparts without NAFLD. Both event rates were particularly increased in those with advanced NAFLD fibrosis. NAFLD was associated with a 5-fold increased risk of 1-year all-cause re-hospitalization (adjusted-hazard ratio 5.05, 95% confidence intervals 2.78–9.10, pacute HF. PMID:28288193

  9. Comparing the predictive accuracy of frailty, comorbidity, and disability for mortality: a 1-year follow-up in patients hospitalized in geriatric wards

    Science.gov (United States)

    Ritt, Martin; Ritt, Julia Isabel; Sieber, Cornel Christian; Gaßmann, Karl-Günter

    2017-01-01

    Background Studies evaluating and comparing the power of frailty, comorbidity, and disability instruments, together and in parallel, for predicting mortality are limited. Objective This study aimed to evaluate and compare the measures of frailty, comorbidity, and disability in predicting 1-year mortality in geriatric inpatients. Design Prospective cohort study. Patients and setting A total of 307 inpatients aged ≥65 years in geriatric wards of a general hospital participated in the study. Measurements The patients were evaluated in relation to different frailty, comorbidity, and disability instruments during their hospital stays. These included three frailty (the seven-category Clinical Frailty Scale [CFS-7], a 41-item frailty index [FI], and the FRAIL scale), two comorbidity (the Cumulative Illness Rating Scale for Geriatrics [CIRS-G] and the comorbidity domain of the FI [Comorbidity-D-FI]), and two disability instruments (disability in basic activities of daily living [ADL-Katz] and the instrumental and basic activities of daily living domains of the FI [IADL/ADL-D-FI]). The patients were followed-up over 1 year. Results Using FI, CIRS-G, Comorbidity-D-FI, and ADL-Katz, this study identified a patient group with a high (≥50%) 1-year mortality rate in all of the patients and the two patient subgroups (ie, patients aged 65–82 years and ≥83 years). The CFS-7, FI, FRAIL scale, CIRS-G, Comorbidity-D-FI, and IADL/ADL-D-FI (analyzed as full scales) revealed useful discriminative accuracy for 1-year mortality (ie, an area under the curve >0.7) in all the patients and the two patient subgroups (all P<0.001). Thereby, CFS-7 (in all patients and the two patient subgroups) and FI (in the subgroup of patients aged ≥83 years) showed greater discriminative accuracy for 1-year mortality compared to other instruments (all P<0.05). Conclusion All the different instruments emerged as suitable tools for risk stratification in geriatric inpatients. Among them, CFS-7, and in

  10. Extensive Renovation of Heritage Buildings

    DEFF Research Database (Denmark)

    Rasmussen, Torben Valdbjørn; Møller, Eva B.; Buch-Hansen, Thomas Cornelius

    2015-01-01

    In the debate on whether or not heritage buildings should be included in work to mitigate climate change impacts, it is important to assess the impact of these buildings. Therefore the results of an extensive energy upgrading of a listed complex was studied. Climate change and measures to mitigate...... its effects have been a global priority for more than a decade. Efforts to mitigate climate change have focused on reducing greenhouse gas emissions, especially CO2. As a consequence, there is an increased interest in reducing the energy consumption and increase the indoor climate standard of many...... feasible energy-upgrading measures for implementation including measures to provide an acceptable indoor climate. The energy savings as well as the reduction of CO2 emissions are calculated. Furthermore, it is discussed how measures can affect the durability of a heritage building, as measures may create...

  11. Think - Baltic Extension / Kalle Kask

    Index Scriptorium Estoniae

    Kask, Kalle

    2002-01-01

    Tallinna TÜ Rehabilitatsiooni tehnoloogia keskus korraldas pressikonverentsi, kus tutvustati osalemist EL V raamprogrammis Think - Baltic Extension, mis on suunatud puuetega inimeste tööhõive tagamisele

  12. Unexpected dominance of 1 year old parr among migrating salmon and sea trout individuals in the River Siesartis, Lithuania

    Directory of Open Access Journals (Sweden)

    Kęstutis Skrupskelis

    2015-12-01

    However, 1 year age parr unexpectedly dominated among salmon juveniles descending towards the Sea in the restocked Siesartis River, which is situated 400 km to the Baltic Sea. The same phenomenon has been observed among migrating sea trout individuals, too. Mass migration of 1 year age salmon and sea trout parr with mean body length ranging from 69 to 150 mm can hardly be explained by density-dependant regulatory mechanisms alone. Possible impact of particularly long distance migration route is also discussed.

  13. "I was born full deaf." Written language outcomes after 1 year of strategic and interactive writing instruction.

    Science.gov (United States)

    Wolbers, Kimberly A; Dostal, Hannah M; Bowers, Lisa M

    2012-01-01

    Nonstandard grammatical forms are often present in the writing of deaf students that are rarely, if ever, seen in the writing of hearing students. With the implementation of Strategic and Interactive Writing Instruction (SIWI) in previous studies, students have demonstrated significant gains in high-level writing skills (e.g., text structure) but have also made gains with English grammar skills. This 1-year study expands on prior research by longitudinally examining the written language growth (i.e., writing length, sentence complexity, sentence awareness, and function words) of 29 deaf middle-school students. A repeated-measures analysis of variance with a between-subjects variable for literacy achievement level was used to examine gains over time and the intervention's efficacy when used with students of various literacy levels. Students, whether high or low achieving, demonstrated statistically significant gains with writing length, sentence complexity, and sentence awareness. Subordinate clauses were found to be an area of difficulty, and follow up strategies are suggested. An analysis of function word data, specifically prepositions and articles, revealed different patterns of written language growth by language group (e.g., American Sign Language users, oral students, users of English-based sign).

  14. EXTENSION EDUCATION SYMPOSIUM: reinventing extension as a resource--what does the future hold?

    Science.gov (United States)

    Mirando, M A; Bewley, J M; Blue, J; Amaral-Phillips, D M; Corriher, V A; Whittet, K M; Arthur, N; Patterson, D J

    2012-10-01

    The mission of the Cooperative Extension Service, as a component of the land-grant university system, is to disseminate new knowledge and to foster its application and use. Opportunities and challenges facing animal agriculture in the United States have changed dramatically over the past few decades and require the use of new approaches and emerging technologies that are available to extension professionals. Increased federal competitive grant funding for extension, the creation of eXtension, the development of smartphone and related electronic technologies, and the rapidly increasing popularity of social media created new opportunities for extension educators to disseminate knowledge to a variety of audiences and engage these audiences in electronic discussions. Competitive grant funding opportunities for extension efforts to advance animal agriculture became available from the USDA National Institute of Food and Agriculture (NIFA) and have increased dramatically in recent years. The majority of NIFA funding opportunities require extension efforts to be integrated with research, and NIFA encourages the use of eXtension and other cutting-edge approaches to extend research to traditional clientele and nontraditional audiences. A case study is presented to illustrate how research and extension were integrated to improve the adoption of AI by beef producers. Those in agriculture are increasingly resorting to the use of social media venues such as Facebook, YouTube, LinkedIn, and Twitter to access information required to support their enterprises. Use of these various approaches by extension educators requires appreciation of the technology and an understanding of how the target audiences access information available on social media. Technology to deliver information is changing rapidly, and Cooperative Extension Service professionals will need to continuously evaluate digital technology and social media tools to appropriately integrate them into learning and

  15. The effect of extensive reading and paired-associate learning on long-term vocabulary retention: an event-related potential study.

    Science.gov (United States)

    Chun, Eunjin; Choi, Sungmook; Kim, Junsoo

    2012-07-19

    We investigated the relative efficacy of extensive reading (ER) and paired-associate learning (PAL) in the ability of second language (L2) learners to retain new vocabulary words. To that end, we combined behavioral measures (i.e., vocabulary tests) and an event-related potential (ERP) investigation with a focus on the N400 ERP component to track short- and long-term vocabulary retention as a consequence of the two different approaches. Behavioral results indicated that both ER and PAL led to substantial short-term retention of the target words. In contrast, on a long-term basis, ER was more effective than PAL to a considerable degree as indicated by a large-size effect (d=1.35). Evidence from the N400 effects (d=1.70) observed in the parietal electrode group (P3, Pz, P4) provided further support for the superior effects of ER over PAL on long-term vocabulary retention. The converging evidence challenges the assumptions of some L2 researchers and makes a significant contribution to the literature of vocabulary acquisition, because it provides the first ERP evidence that ER is more conducive to long-term vocabulary retention than PAL.

  16. Thigh and knee circumference, knee-extension strength, and functional performance after fast-track total hip arthroplasty

    DEFF Research Database (Denmark)

    Holm, Bente; Kristensen, Morten Tange; Husted, Henrik;

    2011-01-01

    OBJECTIVE: To (1) quantify changes in knee-extension strength and functional-performance at discharge after fast-track total hip arthroplasty (THA) and (2) investigate whether these changes correlate to changes in thigh and knee circumference (ie, swelling) or pain. DESIGN: A prospective......, descriptive, hypothesis-generating study. SETTING: A special unit for fast-track hip and knee arthroplasty operations at a university hospital. PARTICIPANTS: Twenty-four patients (20 women and 4 men; ages 69 ± 6.1 years) scheduled for primary unilateral THA. METHODS: All patients were evaluated before surgery...... and on the day of hospital discharge. MAIN OUTCOME MEASURES: Knee-extension strength, thigh and knee joint circumference, hip pain, and functional performance (Timed Up & Go, 30-Second Chair Stand, and 10-Meter Walk tests). RESULTS: All investigated variables changed significantly from before to after surgery...

  17. Characteristics and Motivational Factors of Effective Extension Advisory Leaders

    Science.gov (United States)

    Spearman, Teresa Joy

    2011-01-01

    Building an effective Extension advisory leadership system is essential for Cooperative Extension to ensure the existence and relevance of university outreach programs to meet community needs. The purpose of this study has been to explore characteristics and motivational factors of effective Extension advisory leaders for identifying, motivating,…

  18. Using Authentic Materials for Extensive Reading to Promote English Proficiency

    Science.gov (United States)

    Guo, Siao-cing

    2012-01-01

    Current literature points to the importance and benefits of extensive reading. Extensive reading provides contextualized clues for better reading comprehension (Krashen, 1982), and substantial linguistic input (Bell, 1998) needed for language development. Several studies have found a correlation between extensive reading and specific linguistic…

  19. Frames and extension problems I

    DEFF Research Database (Denmark)

    Christensen, Ole

    2014-01-01

    In this article we present a short survey of frame theory in Hilbert spaces. We discuss Gabor frames and wavelet frames and set the stage for a discussion of various extension principles; this will be presented in the article Frames and extension problems II (joint with H.O. Kim and R.Y. Kim)....

  20. Extensive Reading Coursebooks in China

    Science.gov (United States)

    Renandya, Willy A.; Hu, Guangwei; Xiang, Yu

    2015-01-01

    This article reports on a principle-based evaluation of eight dedicated extensive reading coursebooks published in mainland China and used in many universities across the country. The aim is to determine the extent to which these coursebooks reflect a core set of nine second language acquisition and extensive reading principles. Our analysis shows…