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Sample records for 01llb k58 h21

  1. Preparation of a Lipopolysaccharide from Escherichia coli 01lla, 01llb, k58: h21 bacterial wall, labeled with carbon-14; Preparacion de un lipopolisacarido de la pared baceteriana de escherichia coli 01lla, 01llb, K58: H21, marcado con carbono-14

    Energy Technology Data Exchange (ETDEWEB)

    Solano Aunon, M. L.; Pacheco Lopez, J.; Garcia Pineda, M. D.; Roca, M.; Bayon, A.

    1981-07-01

    A brief description of the morphological and chemical structure of Li po polysaccharides is given, as well as its occurrence in nature and its mechanisms of action. It is emphasized the usefulness for actual biochemical and biomedical research of the labeled Lipopolysaccharide. The method for the labelling, isolation and purification of 14''C-Lipopolysacchari de is described. (Author) 23 refs.

  2. Avia pursuit airplane B.H. 21

    Science.gov (United States)

    Serryer, J

    1926-01-01

    Built by the 'Czecho-Slovakian' aircraft factory, AVIA, the B.H. 21, has a top speed of 250 MPH, and carries 120 kg of gasoline and 20 kg of oil, giving it a radius of action of 600-650 km. It is equipped with a Hispano-Suiza engine capable of 300 HP.

  3. Glycosaminoglycans enhance the fibrillation propensity of the ß2-microglobulin cleavage variant--¿K58-ß2m

    DEFF Research Database (Denmark)

    Corlin, Dorthe B; Johnsen, Christina K; Nissen, Mogens H

    2010-01-01

    in the early aggregates, hereby promoting the assembly of these into fibrils, whereas the copper ions appear to have a destabilizing effect on the monomers. This keeps them in a structure forming amorphous aggregates for a longer period of time, leading to the formation of spherical bodies followed....... In this study, we show that fibrillogenesis of a cleavage variant of ß2m, ¿K58-ß2m, which can be found in the circulation of hemodialysis patients and is able to fibrillate at near-physiological pH in vitro, is affected by the presence of copper ions and heparan sulfate. It is found that the fibrils generated...... when heparan sulfate is present have increased length and diameter, and possess enhanced stability and seeding properties. However, when copper ions are present the fibrils are short, thin and less stable, and form at a slower rate. We suggest that heparan sulfate stabilizes the cleaved monomers...

  4. Observation of a 331 K (58 degrees C) spin transition for bis[hydrotris (1,2,4-triazol-1-yl)borate]iron(II) by variable temperature infrared spectroscopy and magnetic susceptibility measurements

    NARCIS (Netherlands)

    van Koningsbruggen, Petra J.; Miller, Joel S.

    2008-01-01

    Fe{HB(C(2)H(2)N(3))(3)}(2) is observed by variable temperature infrared and magnetic studies to have a spin transition between the low spin S = 0 and high spin S = 2 states at 331 K (58 degrees C) with thermal hysteresis of similar to 1.5 K. Changes in the triazole ligand IR absorptions demonstrate

  5. Genetic Diversity and Virulence Potential of Shiga Toxin-Producing Escherichia coli O113:H21 Strains Isolated from Clinical, Environmental, and Food Sources

    Science.gov (United States)

    Delannoy, Sabine; Lacher, David W.; dos Santos, Luis Fernando; Beutin, Lothar; Fach, Patrick; Rivas, Marta; Hartland, Elizabeth L.; Paton, Adrienne W.; Guth, Beatriz E. C.

    2014-01-01

    Shiga toxin-producing Escherichia coli strains of serotype O113:H21 have caused severe human diseases, but they are unusual in that they do not produce adherence factors coded by the locus of enterocyte effacement. Here, a PCR microarray was used to characterize 65 O113:H21 strains isolated from the environment, food, and clinical infections from various countries. In comparison to the pathogenic strains that were implicated in hemolytic-uremic syndrome in Australia, there were no clear differences between the pathogens and the environmental strains with respect to the 41 genetic markers tested. Furthermore, all of the strains carried only Shiga toxin subtypes associated with human infections, suggesting that the environmental strains have the potential to cause disease. Most of the O113:H21 strains were closely related and belonged in the same clonal group (ST-223), but CRISPR analysis showed a great degree of genetic diversity among the O113:H21 strains. PMID:24858089

  6. Fluorescence Quenching of Anthracene by N,N-Diethylaniline and Phenothiazine in Triton X-100/n-C10H21OH/H2O Microemulsion

    Institute of Scientific and Technical Information of China (English)

    GUO Xia; XU Hui; GUO Rong

    2003-01-01

    The photo-induced electron transfer reactions of anthracene with N,N-diethylaniline(DEA) and phenothiazine(PTZ) occur in the membrane phase of a Triton X-100/n-C10H21OH(1-decanol)/H2O microemulsion. DEA and PTZ exist in the membrane phase of the microemulsion. Anthracene exists in the oil continuous phase of the W/O microemulsion and in the oil core and membrane phase of the O/W microemulsion.

  7. Characterization of a chromosomally integrated luxCDABE marker for investigation of shiga toxin-producing Escherichia coli O91:H21 shedding in cattle

    Science.gov (United States)

    Hong, Yingying; Mathew, Alan G.

    2011-06-01

    Shiga toxin-producing Escherichia coli (STEC) O91:H21 has been recognized as a potential life-threatening foodborne pathogen and is commonly involved in human infections in European countries. Fecal shedding of the organism by cattle is considered to be the ultimate source for contaminations. Studies examining STEC shedding patterns often include inoculation of strains carrying antibiotic resistance makers for identifiable recovery. However, indigenous intestinal microflora exhibiting similar antibiotic resistance patterns can confound such studies. Such was the case in a study by our group when attempting to characterize shedding patterns of O91:H21 in calves. A chromosomally integrated bioluminescence marker using a luxCDABE cassette from Photorhabdus luminescens was developed in O91:H21 to overcome such shortcomings of antibiotic resistance markers during animal challenge experiment. The marker was validated in various aspects and was shown to have no impact on metabolic reactions, isotype virulence gene patterns, cost to growth, and additionally demonstrated high in vitro stability. Together, the results indicated that a chromosomally integrated luxCDABE based marker may be a superior system for the study of STEC colonization and shedding in cattle.

  8. Radioimmunoscintigraphy of colorectal carcinoma using technetium-99m-labeled, totally human monoclonal antibody 88BV59H21-2.

    Science.gov (United States)

    Gulec, S A; Serafini, A N; Moffat, F L; Vargas-Cuba, R D; Sfakianakis, G N; Franceschi, D; Crichton, V Z; Subramanian, R; Klein, J L; De Jager, R L

    1995-12-01

    Radioimmunoscintigraphy (RIS) using human monoclonal antibodies offers the important clinical advantage of repeated imaging over murine monoclonal antibodies by eliminating the cross-species antibody response. This article reports a Phase I-II clinical trial with Tc-99m-labeled, totally human monoclonal antibody 88BV59H21-2 in patients with colorectal carcinoma. The study population consisted of 34 patients with colorectal cancer (20 men and 14 women; age range, 44-81 years). Patients were administered 5-10 mg antibody labeled with 21-41 mCi Tc-99m by the i.v. route and imaged at 3-10 and 16-24 h after infusion using planar and single-photon emission computed tomographic (CT) techniques. Pathological confirmation was obtained in 25 patients who underwent surgery. Human antihuman antibody (HAHA) titers were checked prior to and 1 and 3 months after the infusion. RIS with Tc-99m-labeled 88BV59H21-2 revealed a better detection rate in the abdomen-pelvis region compared with axial CT. The combined use of both modalities increased the sensitivity in both the liver and abdomen-pelvis regions. Ten patients developed mild adverse reactions (chills and fever). No HAHA response was detected in this series. Tc-99m-labeled human monoclonal antibody 88BV59H21-2 RIS shows promise as a useful diagnostic modality in patients with colorectal cancer. RIS alone or in combination with CT is more sensitive than CT in detecting tumor within the abdomen and pelvis. Repeated RIS studies may be possible, due to the lack of a HAHA response.

  9. A new alpha-globin variant with increased oxygen affinity in a Swiss family: Hb Frauenfeld [alpha 138(H21)Ser-->Phe, TCC>TTC (alpha 2)].

    Science.gov (United States)

    Hochuli, Michel; Zurbriggen, Karin; Schmid, Marlis; Speer, Oliver; Rochat, Philippe; Frauchiger, Beat; Kleinert, Peter; Schmugge, Markus; Troxler, Heinz

    2009-01-01

    A new alpha-globin mutation [alpha 138(H21)Ser-->Phe] was found in a 55-year-old male proband with an erythrocytosis known since his youth. Cation exchange high performance liquid chromatography (HPLC) revealed an additional peak eluting slightly before Hb A indicating the presence of a variant. The peak area of the variant was approximately one-third that of Hb A suggesting an alpha-globin variant. Matrix-assisted laser desorption ionization-time-of-flight mass spectrometry analysis confirmed the mutation at the protein level. The variant is also detectable with isoelectric focusing and reversed phase HPLC. DNA analysis revealed a heterozygous sequence mutation at codon 138 of the alpha2 gene. A C>T transition at the second nucleotide of the codon indicated a Ser-->Phe exchange. The variant showed increased oxygen affinity and was named Hb Frauenfeld.

  10. C15H21RuSe

    Science.gov (United States)

    Mikhova, B. M.

    This document is part of Subvolume D5 `Chemical Shifts and Coupling Constants for Carbon-13. Part 5: Organometallic Compounds' of Volume 35 `Nuclear Magnetic Resonance Data' of Landolt-Börnstein Group III: `Condensed Matter'.

  11. Hemoglobin Syracuse (alpha2beta2-143(H21)His leads to Pro), a new high-affinity variant detected by special electrophoretic methods. Observations on the auto-oxidation of normal and variant hemoglobins.

    Science.gov (United States)

    Jensen, M; Oski, F A; Nathan, D G; Bunn, H F

    1975-01-01

    Family members from four generations were found to have polycythemia and increased whole blood O2 affinity (P50; 11 mm Hg; normal, 27 mm Hg). No abnormal hemoglobin bands were seen after electrophoresis on starch gel at pH 8.6 or agar gel at pH 6.0. Analysis of the oxygenated hemolysate by isoelectric focusing on polyacrylamide gel revealed two closely spaced bands. When deoxygenated hemolysate was analyzed in oxygen-free gels, the two components were more widely separated. About 40% of the patient's hemoglobin focused at a more acid pH than hemoglobin A, indicating a hemoglobin variant with impaired Bohr effect. Chromatography of globin in 8 M urea revealed two beta-chain peaks, the first of which was eluted at a lower buffer molarity than normal beta chain. Fingerprints of tryptic digests of the aminoethylated chains were done on silica gel thin-layer plates. Tp 14 from the abnormal beta chain had slower electrophoretic mobility and a greater Rf value. Amino acid analyses of this peptide gave values identical with those of betaTp 14, except that it contained one proline residue and no histidine. Since the one His in betaTp 14 is in position 143, hemoglobin Syracuse in alpha2beta2-143 His leads to Pro. Native Hb Syracuse could be separated from hemoglobin A on a carboxymethylcellulose column. The inclusion of 0.1 mM EDTA in the preparative buffers proved very useful in reducing the formation of methemoglobin. Oxygen equilibria of purified hemoglobin Syracuse showed high oxygen affinity (P50 value 12% that of hemoglobin A) and lack of cooperativity between subunits (Hill's n equals 1.1). The alkaline Bohr effect was about half that of hemoglobin A. The proline substitution at betaH21 disrupts the helical configuration and probably prevents the formation of salt bonds that are important in stabilizing the deoxy structure and contribute to the alkaline Bohr effect. Since beta143 His is a binding site for 2,3-diphosphoglycerate (2,3-DPG), it is not suprising that

  12. The Regulation of Expression of the Stx2d Toxins in Shiga Toxin-producing Escherichia coli O91:H21 Strain B2F1

    Science.gov (United States)

    2002-01-01

    EHEC 1 group consists only of O157:H7 and O157:NM, two serotypes that appear to represent recent clones that have spread globally . Members of the...which carnitine is used in the bacterial cell (Fig. 22). The role this gene might have as a global regulator is unclear; however, the caiD-coding...mRNA secondary structure in differential expression of Shiga toxin genes J.Bacteriol. 175: 597-603. Hamilton,C.M., Aldea ,M., Washburn,B.K

  13. SPECIAL SESSION: (H21) on Global Precipitation Mission for Hydrology and Hydrometeorology. Sampling-Error Considerations for GPM-Era Rainfall Products

    Science.gov (United States)

    Bell, Thomas L.; Lau, William K. M. (Technical Monitor)

    2002-01-01

    The proposed Global Precipitation Mission (GPM) builds on the success of the Tropical Rainfall Measuring Mission (TRMM), offering a constellation of microwave-sensor-equipped smaller satellites in addition to a larger, multiply-instrumented "mother" satellite that will include an improved precipitation radar system to which the precipitation estimates of the smaller satellites can be tuned. Coverage by the satellites will be nearly global rather than being confined as TRMM was to lower latitudes. It is hoped that the satellite constellation can provide observations at most places on the earth at least once every three hours, though practical considerations may force some compromises. The GPM system offers the possibility of providing precipitation maps with much better time resolution than the monthly averages around which TRMM was planned, and therefore opens up new possibilities for hydrology and data assimilation into models. In this talk, methods that were developed for estimating sampling error in the rainfall averages that TRMM is providing will be used to estimate sampling error levels for GPM-era configurations. Possible impacts on GPM products of compromises in the sampling frequency will be discussed.

  14. Mutations in the Histone-like Nucleoid Structuring Regulatory Gene (hns) Decrease the Adherence of Shiga Toxin-producing Escherichia coli 091:H21 Strain B2F1 to Human Colonic Epithelial Cells and Increase the Production of Hemolysin

    Science.gov (United States)

    1999-10-19

    long wave ultra- violet light (Chapman et aI., 1991; Zadik et al., 1993). Because 0157:H7 strains are negative for p-glucuronidase this test...by cross-linking with ultra violet (UV) light (Church and Gilbert, 1984). The blot was blocked at least 4 hours before addition of labeled probe (see...with a trans-blot SO semi-dry apparatus (Bio-Rad). The membranes were blocked with 5% nonfat dried milk ( Carnation Co., Los Angeles, CAl in Tris

  15. Dicty_cDB: Contig-U03047-1 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available ,37h,61h La... 46 4.2 1 ( EX346464 ) GQ03103.SP6_H21 GQ031 - Xylem Scrapings (Normaliz... 46 4.2 1 ( EX34611...2 ) GQ03103.SP6.1_H21 GQ031 - Xylem Scrapings (Normal... 46 4.2 1 ( EX345398 ) GQ03103.B7.1_H21 GQ031 - Xylem Scraping

  16. Coupling Graphene Sheets with Magnetic Nanoparticles for Energy Storage and Microelectronics

    Science.gov (United States)

    2015-08-13

    corrected STM images obtained: (a) in air on a monolayer graphene substrate grown by chemical vapor deposition on a polycrystalline copper foil...substrate imposed by the polycrystalline copper carrier material (as shown by Figure 19b, which was acquired over a particularly rough surface area...HOPG and graphene building blocks bearing a ligand to the upper deck of the pillar in order to promote ligand exchange. OC10H21OC10H21 OC10H21 OC10H21

  17. Transformational leadership sub-dimensions and their link to leaders' personality and performance

    NARCIS (Netherlands)

    Deinert, A.; Homan, A.C.; Boer, D.; Voelpel, S.C.; Gutermann, D.

    2015-01-01

    The multi-dimensionality of the transformational leadership construct has been under debate in the last decades. To shed more light on this issue, we conducted a meta-analysis (k = 58 studies), examining the transformational leadership sub-dimensions and their links to leader personality and perform

  18. Transformational leadership sub-dimensions and their link to leaders' personality and performance

    NARCIS (Netherlands)

    Deinert, A.; Homan, A.C.; Boer, D.; Voelpel, S.C.; Gutermann, D.

    2015-01-01

    The multi-dimensionality of the transformational leadership construct has been under debate in the last decades. To shed more light on this issue, we conducted a meta-analysis (k = 58 studies), examining the transformational leadership sub-dimensions and their links to leader personality and

  19. AcEST: DK960100 [AcEST

    Lifescience Database Archive (English)

    Full Text Available 1. 5' end sequence. DK960100 - Show DK960100 Clone id TST39A01NGRL0006_H21 Library TST39 Length 690 Definiti...on Adiantum capillus-veneris mRNA. clone: TST39A01NGRL0006_H21. 5' end sequence. Accession DK960100 Tissue t...tein database search programs, Nucleic Acids Res. 25:3389-3402. Query= DK960100|Adiantum capillus-veneris mR...ucleic Acids Res. 25:3389-3402. Query= DK960100|Adiantum capillus-veneris mRNA, clone: TST39A01NGRL0006_H21,

  20. Studies on the Biology of the Tube-Building Amphipod Microdeutopus gryllotalpa. A Model for Marine Fouling Processes.

    Science.gov (United States)

    1984-01-01

    144-153. Dingle, H. & Caldwell, R.L. 1972. Reproductive and maternal behaicr of the mantis shrimp Gonodactylus bredini manning (Crustacea: Stomatopoda...restricted to Acknowledgements. I thank P. Fenimore for his help in the peracarids. Individuals of the snapping shrimp Alpheus collecting animals, and R...Knowlton. N.: Sexual selection and dimorphism in two demes of mar. biol. Ass. U.K. 58. 585-596 (1978) a symbiotic. snapping shrimp . Evolution 34. 161

  1. SwissProt search result: AK069229 [KOME

    Lifescience Database Archive (English)

    Full Text Available AK069229 J023012H21 (Q9TV66) Potassium/sodium hyperpolarization-activated cyclic nu...cleotide-gated channel 4 (Hyperpolarization-activated cation channel 4) (HAC-4) HCN4_RABIT 9e-16 ...

  2. SwissProt search result: AK069229 [KOME

    Lifescience Database Archive (English)

    Full Text Available AK069229 J023012H21 (O88705) Potassium/sodium hyperpolarization-activated cyclic nu...cleotide-gated channel 3 (Hyperpolarization-activated cation channel 3) (HAC-3) HCN3_MOUSE 4e-16 ...

  3. AcEST: DK952954 [AcEST

    Lifescience Database Archive (English)

    Full Text Available TST38A01NGRL0015_H21 616 Adiantum capillus-veneris mRNA. clone: TST38A01NGRL0015_H21. 5' end sequence. DK95...2954 - Show DK952954 Clone id TST38A01NGRL0015_H21 Library TST38 Length 616 Definiti...on Adiantum capillus-veneris mRNA. clone: TST38A01NGRL0015_H21. 5' end sequence. Accession DK952954 Tissue t... of protein database search programs, Nucleic Acids Res. 25:3389-3402. Query= DK952954|Adiantum capillus-ven...2 G 544 G Sbjct: 565 G 565 Score = 79.7 bits (195), Expect = 1e-14 Identities = 5

  4. Survival in acidic and alcoholic medium of Shiga toxin-producing Escherichia coli O157:H7 and non-O157:H7 isolated in Argentina

    Directory of Open Access Journals (Sweden)

    Sanz Marcelo E

    2003-08-01

    Full Text Available Abstract Background In spite of Argentina having one of the highest frequencies of haemolytic uraemic syndrome (HUS, the incidence of Escherichia coli O157:H7 is low in comparison to rates registered in the US. Isolation of several non-O157 shiga toxin-producing Escherichia coli (STEC strains from cattle and foods suggests that E. coli O157:H7 is an uncommon serotype in Argentina. The present study was undertaken to compare the survival rates of selected non-O157 STEC strains under acidic and alcoholic stress conditions, using an E. coli O157:H7 strain as reference. Results Growth at 37°C of E. coli O26:H11, O88:H21, O91:H21, O111:H-, O113:H21, O116:H21, O117:H7, O157:H7, O171:H2 and OX3:H21, was found to occur at pH higher than 4.0. When the strains were challenged to acid tolerance at pH as low as 2.5, viability extended beyond 8 h, but none of the bacteria, except E. coli O91:H21, could survive longer than 24 h, the autochthonous E. coli O91:H21 being the more resistant serotype. No survival was found after 24 h in Luria Bertani broth supplemented with 12% ethanol, but all these serotypes were shown to be very resistant to 6% ethanol. E. coli O91:H21 showed the highest resistance among serotypes tested. Conclusions This information is relevant in food industry, which strongly relies on the acid or alcoholic conditions to inactivate pathogens. This study revealed that stress resistance of some STEC serotypes isolated in Argentina is higher than that for E. coli O157:H7.

  5. A novel chalcone derivative attenuates the diabetes-induced renal injury via inhibition of high glucose-mediated inflammatory response and macrophage infiltration

    Energy Technology Data Exchange (ETDEWEB)

    Fang, Qilu [Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang (China); Zhao, Leping [Department of Pharmacy, the Affiliated Yueqing Hospital, Wenzhou Medical University, Wenzhou, Zhejiang (China); Wang, Yi; Zhang, Yali [Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang (China); Li, Zhaoyu [Department of International High School, Shanghai Jiaotong University Nanyang Affiliated (Kunshan) School, Minhang District, Shanghai (China); Pan, Yong; Kanchana, Karvannan; Wang, Jingying; Tong, Chao [Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang (China); Li, Dan, E-mail: yqyyld@163.com [Department of Nephrology, the Affiliated Yueqing Hospital, Wenzhou Medical University, Wenzhou, Zhejiang (China); Liang, Guang, E-mail: wzmcliangguang@163.com [Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang (China)

    2015-01-15

    Inflammation plays a central role in the development and progression of diabetic nephropathy (DN). Researches on novel anti-inflammatory agents may offer new opportunities for the treatment of DN. We previously found a chalcone derivative L6H21 could inhibit LPS-induced cytokine release from macrophages. The aim of this study was to investigate whether L6H21 could ameliorate the high glucose-mediated inflammation in NRK-52E cells and attenuate the inflammation-mediated renal injury. According to the results, L6H21 showed a great inhibitory effect on the expression of pro-inflammatory cytokines, cell adhesion molecules, chemokines, and macrophage adhesion via down-regulation of NF-κB/MAPKs activity in high glucose-stimulated renal NRK-52E cells. Further, in vivo oral administration with L6H21 at a dosage of 20 mg/kg/2 days showed a decreased expression of pro-inflammatory cytokines, cell adhesion molecules, which subsequently contributed to the inhibition on renal macrophage infiltration, the reduction of serum creatinine and BUN levels, and the improvement on the fibrosis and pathological changes in the renal tissues of diabetic mice. These findings provided that chalcone derived L6H21 may be a promising anti-inflammatory agent and have the potential in the therapy of diabetic nephropathy, and importantly, MAPK/NF-κB signaling system may be a novel therapeutic target for human DN in the future. - Highlights: • Inflammation plays a central role in the development of diabetic nephropathy. • Compound L6H21 reduced the high glucose-mediated inflammation in NRK-52E cells. • Compound L6H21 attenuated the inflammation-mediated renal injury. • L6H21 exhibited anti-inflammatory effects via inactivation of NF-κB/MAPKs. • MAPKs/NF-κB may be a novel therapeutic target in diabetic nephropathy treatment.

  6. Dicty_cDB: VSF780 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available 0.17 1 BU572652 |BU572652.1 PA__Ea0001H21f Almond developing seed Prunus dulcis cDNA clone PA__Ea0001H21f, ...mic clone UUGC1M0399K06 R, DNA sequence. 48 0.17 1 BU573578 |BU573578.1 PA__Ea0004H03f Almond developing

  7. Half-a-Century of the »Körmend Growth Study«

    OpenAIRE

    Eiben, O. G.; Tóth, G.

    2000-01-01

    The authors give a sketch about the „Körmend Growth Study« which is series of cross-sectional growth studies, carried out in Körmend, a small town in Western Hungary. The first investigation was carried out in 1958 (K-58) and it has been repeated every ten years (K-68, K-78, K-88, and K-98). All 3-18 year-old healthy boys and girls in nurseries and schools in Körmend were involved in the study. Twenty-three body measurements were taken. This paper focuses on changes in height, ...

  8. Amino Acid Substitutions That Affect Receptor Binding and Stability of the Hemagglutinin of Influenza A/H7N9 Virus

    Science.gov (United States)

    Schrauwen, Eefje J. A.; Burke, David F.; Rimmelzwaan, Guus F.; Herfst, Sander; Fouchier, Ron A. M.

    2016-01-01

    Receptor-binding preference and stability of hemagglutinin have been implicated as crucial determinants of airborne transmission of influenza viruses. Here, amino acid substitutions previously identified to affect these traits were tested in the context of an A/H7N9 virus. Some combinations of substitutions, most notably G219S and K58I, resulted in relatively high affinity for α2,6-linked sialic acid receptor and acid and temperature stability. Thus, the hemagglutinin of the A/H7N9 virus may adopt traits associated with airborne transmission. PMID:26792744

  9. AcEST: DK950000 [AcEST

    Lifescience Database Archive (English)

    Full Text Available TST38A01NGRL0007_H21 704 Adiantum capillus-veneris mRNA. clone: TST38A01NGRL0007_H2...1. 5' end sequence. DK950000 CL57Contig1 Show DK950000 Clone id TST38A01NGRL0007_H21 Library TST38 Length 70...4 Definition Adiantum capillus-veneris mRNA. clone: TST38A01NGRL0007_H21. 5' end sequence. Accession DK95000...tabase search programs, Nucleic Acids Res. 25:3389-3402. Query= DK950000|Adiantum...T: a new generation of protein database search programs, Nucleic Acids Res. 25:3389-3402. Query= DK9500

  10. 早熟玉米新品种海玉14的选育及栽培技术

    Institute of Scientific and Technical Information of China (English)

    隋冬华; 唐贵; 唐克; 李瑞

    2012-01-01

    海玉14是海伦东升种业有限责任公司科研所2003年以自选系H20为母本,外引系H21为父本杂交选育而成。母本H20是合344与自330的二环系,父本H21是外引不稳定材料经多代连续自交选育而成的自交系。

  11. Recurrent Hemolytic and Uremic Syndrome Induced by Escherichia Coli

    Science.gov (United States)

    Commereuc, Morgane; Weill, Francois-Xavier; Loukiadis, Estelle; Gouali, Malika; Gleizal, Audrey; Kormann, Raphaël; Ridel, Christophe; Frémeaux-Bacchi, Véronique; Rondeau, Eric; Hertig, Alexandre

    2016-01-01

    Abstract A widespread belief is that typical hemolytic and uremic syndrome (HUS) does not recur. We report the case of a patient infected twice with raw milk taken from his own cow and containing a Shiga toxin–producing Escherichia coli O174:H21 that induced recurrent HUS causing severe renal and cerebral disorders. A genomic comparison of the human and bovine Shiga toxin–producing Escherichia coli O174:H21 isolates revealed that they were identical. Typical HUS may recur. Since milk from this animal was occasionally distributed locally, thereby posing a serious threat for the whole village, this particular cow was destroyed. PMID:26735524

  12. Coupling Graphene Sheets with Iron Oxide Nanoparticles for Energy Storage and Microelectronics

    Science.gov (United States)

    2015-12-18

    polycrystalline copper foil showing the alveolar graphene atomic structure (2.2x2.2 nm, setpoint lT=110pA, sample bias VB= -350 mV), and (b,c) at the...areas and protrusions on the substrate imposed by the polycrystalline copper carrier material (as shown by Figure 19b, which was acquired over a...and adsorb on HOPG and graphene building blocks bearing a ligand to the upper deck of the pillar in order to promote ligand exchange. OC10H21OC10H21

  13. Unfolding, aggregation, and seeded amyloid formation of lysine-58-cleaved beta(2)-microglobulin

    DEFF Research Database (Denmark)

    Heegaard, N.H.H.; Jørgensen, T.J.D.; Rozlosnik, N.;

    2005-01-01

    beta(2)-Microglobulin (beta(2)m) is the amyloidogenic protein in dialysis-related amyloidosis, but the mechanisms underlying beta(2)m fibrillogenesis in vivo are largely unknown. We study a structural variant of beta(2)M that has been linked to cancer and inflammation and may be present in the ci......beta(2)-Microglobulin (beta(2)m) is the amyloidogenic protein in dialysis-related amyloidosis, but the mechanisms underlying beta(2)m fibrillogenesis in vivo are largely unknown. We study a structural variant of beta(2)M that has been linked to cancer and inflammation and may be present...... in the circulation of dialysis patients. This beta(2)M variant, Delta K58-beta(2)m, is a disulfide-linked two-chain molecule consisting of amino acid residues 1-57 and 59-99 of intact beta(2)m, and we here demonstrate and characterize its decreased conformational stability as compared to wild-type (wt) beta(2)M......, and at 37 degrees C the half-time for unfolding is more than 170-fold faster than at 15 degrees C. Conformational changes are also reflected by a very prominent Congo red binding of Delta K58-beta(2)m at 37 degrees C, by the evolution of thioflavin T fluorescence, and by changes in intrinsic fluorescence...

  14. Influence of acid-soluble proteins from bivalve Siliqua radiata ligaments on calcium carbonate crystal growth

    Science.gov (United States)

    Huang, Zeng-Qiong; Zhang, Gang-Sheng

    2016-08-01

    In vitro biomimetic synthesis of calcium carbonate (CaCO3) in the presence of shell proteins is a heavily researched topic in biomineralization. However, little is known regarding the function of bivalve ligament proteins in the growth of CaCO3 crystals. In this study, using fibrous protein K58 from Siliqua radiata ligaments or coverslips as substrates, we report the results of our study of CaCO3 precipitation in the presence or absence of acid-soluble proteins (ASP) from inner ligament layers. ASP can disturb the controlling function of K58 or a coverslip on the crystalline phase, resulting in the formation of aragonite, calcite, and vaterite. In addition, we identified the following four primary components from ASP by mass spectroscopy: alkaline phosphatase (ALP), ABC transporter, keratin type II cytoskeletal 1 (KRT 1), and phosphate ABC transporter, phosphate-binding protein (PstS). Further analysis revealed that the first three proteins and especially ALP, which is important in bone mineralisation, could affect the polymorphism and morphology of CaCO3 crystals by trapping calcium ions in their domains. Our results indicate that ALP may play an important role in the formation of aragonite in S. radiata ligaments. This paper may facilitate our understanding of the biomineralization process.

  15. Drug: D07572 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available D07572 Drug Amylocaine hydrochloride; Dolodent (TN) C14H21NO2. HCl 271.1339 271.783 D07572.gif Local anesthe...tic map07015 Local analgesics CAS: 532-59-2 PubChem: 51091891 LigandBox: D07572 NIK

  16. Drug: D06376 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available hetic [topical] Component of Otodyne (TN) CAS: 1155-03-9 PubChem: 47208033 LigandBo...D06376 Drug Zolamine hydrochloride (USAN) C15H21N3OS. HCl 327.1172 327.8727 D06376.gif Antihistaminic; Anest

  17. 2,5,11,14-Tetraoxa-8-azadispiro[13.4.0]nonadeca-15,17,19-triene

    Directory of Open Access Journals (Sweden)

    Quanying Gan

    2010-05-01

    Full Text Available The title compound, C14H21NO4, has been synthesized from o-dihydroxybenzene by a three-step reaction. There are two chemically equal but crystallographically independent molecules in the asymmetric unit. The crystal packing is governed by C—H...O hydrogen bonds and C—H...π interactions, forming an infinite network.

  18. (9E)-9-benzylidene-2-methylsulfanyl-5-phenyl-6,7,8,9-tetrahydropyrimido[4,5-b]quinolin-4(3H)-one: a hydrogen-bonded R2(2)(8) dimer.

    Science.gov (United States)

    Becerra, Diana; Insuasty, Braulio; Cobo, Justo; Glidewell, Christopher

    2013-12-15

    In the molecule of the title compound, C25H21N3OS, which was prepared by mild oxidation of the corresponding 5,6,7,8,9,10-hexahydro analogue, the fused carbocyclic ring adopts an envelope conformation. Pairs of molecules are linked into cyclic centrosymmetric dimers by pairs of inversion-related N-H···O hydrogen bonds.

  19. Deacetyl tenuazonic acid p-toluenesulfonylhydrazone

    Directory of Open Access Journals (Sweden)

    Irene Nehls

    2009-12-01

    Full Text Available The title compound {systematic name: 4-methyl-N′-[(3E-2-(1-methylpropyl-5-oxopyrrolidin-3-ylidene]benzenesulfonohydrazide}, C15H21N3O3S, is the condensation product of deacetyl tenuazonic acid (DTA and p-toluenesulfonohydrazide. The crystal structure consists of chains along [100] linked by N—H...O hydrogen bonds.

  20. Neglette ma essenziali: le imposte dei governi sub-nazionali. Una rassegna internazionale

    Directory of Open Access Journals (Sweden)

    G. BROSIO

    2013-10-01

    Full Text Available This work offers an updated review of the fiscal instruments available for the financing of sub-national governments. It is based essentially on the experiences observed in developing countries, however, some reference is also made to underdeveloped countries and those of the East.  JEL Codes: H21Keywords: Financing, sub-national governments, developing countries

  1. 27 CFR 21.49 - Formula No. 23-H.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Formula No. 23-H. 21.49 Section 21.49 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT... and Authorized Uses § 21.49 Formula No. 23-H. (a) Formula. To every 100 gallons of alcohol add:...

  2. Dicty_cDB: SLE886 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available at Anthesis cDN... 64 9e-23 4 ( CX643299 ) UCRPT02_67F01_b Poncirus trifoliata Roots with Ir... 64 1e-22 4 ...( CX643300 ) UCRPT02_67F01_g Poncirus trifoliata Roots with Ir... 64 1e-22 4 ( CF833900 ) UCRCS02_04H21_f Ru

  3. Drug: D08420 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available D08420 Drug Primaquine (INN); Kanaprim (TN) C15H21N3O 259.1685 259.3467 D08420.gif Antiprotozoa...oquinolines P01BA03 Primaquine D08420 Primaquine (INN) USP drug classification [BR:br08302] Antiparasitics Antiprotozoa

  4. Drug: D01595 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available D01595 Drug Phenyliodoundecynoate (JAN) C17H21IO2 384.0586 384.2519 D01595.gif CAS:... 2020-25-9 PubChem: 7848658 LigandBox: D01595 NIKKAJI: J186.731H ATOM 20 1 C8x C 15.5299 -19.1738 2 C8x C 15

  5. EST Table: FY000874 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available FY000874 bmov3h21 11/11/04 65 %/109 aa ref|XP_970998.1| PREDICTED: similar to Evolution...%/109 aa gi|91094187|ref|XP_970998.1| PREDICTED: similar to Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial [Tribolium castaneum] FS756091 bmov ...

  6. EST Table: FY011605 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available FY011605 rbmov3h21 11/11/04 49 %/238 aa ref|XP_970998.1| PREDICTED: similar to Evolution..._970998.1| PREDICTED: similar to Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial [Tribolium castaneum] FY016706 bmov ...

  7. Drug: D05830 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available D05830 Drug Sermetacin (USAN/INN) C22H21ClN2O6 444.1088 444.8649 D05830.gif Anti-in...flammatory CAS: 57645-05-3 PubChem: 47207491 LigandBox: D05830 NIKKAJI: J14.534C ATOM 31 1 C8y C 22.6554 -22

  8. Drug: D01465 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available D01465 Drug Nizofenone fumarate (JAN); Ekonal (TN) C21H21ClN4O3. C4H4O4 528.1412 528.9416 D01465.gif Nootrop...ic; Vasodilator,cerebral Therapeutic category: 2190 ATC code: N06BX10 Thromboxane A

  9. SwissProt search result: AK069229 [KOME

    Lifescience Database Archive (English)

    Full Text Available AK069229 J023012H21 (P59111) Potassium voltage-gated channel subfamily H member 8 (...Voltage-gated potassium channel subunit Kv12.1) (Ether-a-go-go-like potassium channel 3) (ELK channel 3) (ELK3) (Fragment) KCNH8_MOUSE 8e-17 ...

  10. 2-[2-(2-Hydroxyethoxyphenyl]-4,4,5,5-tetramethyl-2-imidazoline-1-oxyl 3-oxide

    Directory of Open Access Journals (Sweden)

    Lin-Lin Jing

    2011-12-01

    Full Text Available In the title compound, C15H21N2O4, the nitronyl nitroxide unit displays a twisted conformation. The crystal structure is stabilized by non-classical C—H...O and C—H...π hydrogen bonds, which build up a three-dimensional network.

  11. Dichlorido(η6-toluene[tris(4-methoxyphenylphosphine]ruthenium(II

    Directory of Open Access Journals (Sweden)

    Rui-Xiang Li

    2008-02-01

    Full Text Available In the title compound, [RuCl2(C7H8(C21H21O3P], the RuII atom possesses a pseudo-octahedral geometry and the metrical parameters around the metallic core compare well with those of similar three-legged-piano-stool complexes.

  12. Characterization and virulence potential of serogroup O113 Shiga toxin-producing Escherichia coli strains isolated from beef and cattle in the United States

    Science.gov (United States)

    Shiga toxin-producing Escherichia coli (STEC) of serotype O113:H21 have caused severe diseases but are unusual in that they do not produce the intimin protein required for adherence to intestinal epithelial cells. Strains of serogroup O113 are one of the most common STEC found in ground beef and be...

  13. Drug: D08757 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available Neurolite (TN) C12H21N2O5S2. Tc. 433.9956 436.3417 Therapeutic category: 4300 Therapeutic category of drugs... in Japan [BR:br08301] 4 Agents affecting cellular function 43 Radioactive drugs 430 Radioactive drugs 4300 Radioactive drugs

  14. Sendero Luminoso: Case Study in Insurgency

    Science.gov (United States)

    1993-01-01

    Guzman grew up in Arequipa, where he learned that violence could produce radical change. He was also influenced by the Peruvian Marxist Jose Carlos 64...16H 21. 13, Russell Watson and Brook Lamar, "It’s Your Tum to Lose," Newsweek, 28 September 1992, pp. 28~29. 14. Jorge Castaneda , "The Decline of

  15. Drug: D10370 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available D10370 Drug Mavatrep (USAN) C25H21F3N2O 422.1606 422.4423 D10370.gif Treatment of pain vanillo... Ion channels Related to voltage-gated cation channels Transient receptor potential family, TRPV (Vanilloid)

  16. N,N-Dimethyl-3-(1-naphthyloxy-3-(2-thienylpropan-1-amine

    Directory of Open Access Journals (Sweden)

    Jin-Tang Wang

    2008-03-01

    Full Text Available The title compound, C19H21NOS, is an intermediate for the synthesis of duloxetine hydrochloride. In the molecular structure, the thiophene and naphthalene ring systems make a dihedral angle of 87.5°. All bond lengths and angles involving heteroatoms are as expected. In the crystal structure, no classical hydrogen bonds are found.

  17. Dicty_cDB: Contig-U15711-1 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available B3_G22 GQ020: Clean ROOTS systems -Diurnal... 38 0.30 2 ( DV981985 ) GQ0167.B3_H21 GQ016: Primary, secondary... SHOOT -N ... 38 0.30 2 ( DV986039 ) GQ0207.B3_C18 GQ020: Clean ROOTS systems -Diurnal... 38 0.30 2 ( AZ6931

  18. Drug: D07307 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available D07307 Drug Cyamemazine (INN); Tercian (TN) C19H21N3S 323.1456 323.4551 D07307.gif Neuroleptic; Antihistamin...ic ATC code: N05AA06 Anatomical Therapeutic Chemical (ATC) classification [BR:br083

  19. Drug: D07756 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available 07756.gif Neuroleptic; Antihistaminic ATC code: N05AA06 Anatomical Therapeutic Chemical (ATC) classification...D07756 Drug Cyamemazine tartrate; Tercian (TN) C19H21N3S. C4H6O6 473.1621 473.542 D

  20. Drug: D02091 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available staminic ATC code: D04AA04 R06AC04 H1-receptor antagonist [HSA:3269] [KO:K04149] hs...D02091 Drug Tripelennamine hydrochloride (USP); PBZ-SR (TN) C16H21N3. HCl 291.1502 291.819 D02091.gif Antihi

  1. 1,5,6-Triphenyl-8-oxa-7-selena-6-phosphabicyclo[3.2.1]octane-6-selone

    Directory of Open Access Journals (Sweden)

    Yang Li

    2008-01-01

    Full Text Available The structure of the title compound, C23H21OPSe2, consists of fused puckered five- and six-membered rings, PSeC2O and C5O, respectively, with a C2O bridgehead. The C5O ring adopts a chair conformation, whilst the C2PSeO ring has an envelope conformation.

  2. Drug: D05173 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available D05173 Drug Nisoxetine (USAN/INN) C17H21NO2 271.1572 271.3541 D05173.gif Antidepressant Selective nora...drenalin reuptake inhibitor noradrenalin transporter inhibitor [HSA:6530] [KO:K05035] map... Solute carrier family SLC6 SLC6A2 (noradrenalin transporter) [HSA:6530] [KO:K050

  3. Drug: D00196 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available D00196 Drug Physostigmine (USP); Eserine (TN) C15H21N3O2 275.1634 275.3461 D00196.g... D00196 Physostigmine (USP) CAS: 57-47-6 PubChem: 7847264 DrugBank: DB00981 LigandBox: D00196 NIKKAJI: J4.57

  4. 6-Chloro-2,4-bis(dimethylamino-1,3,5-trimethylborazine

    Directory of Open Access Journals (Sweden)

    Mark A. Rodriguez

    2013-02-01

    Full Text Available The borazine ring of the title molecule, C7H21B3ClN5, shows a mild distortion from a planar to a flattened boat conformation. Steric effects due to the methyl and dimethylamine substituents appear to be the cause of this distortion.

  5. Drug: D06633 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available 33.gif Insomnia, major depression, and schizophrenia 5-HT2A-receptor antagonist [HSA:3356] [KO:K04157] hsa04...D06633 Drug Pruvanserin hydrochloride (USAN) C22H21FN4O. HCl 412.1466 412.8877 D066

  6. Drug: D02968 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available 2968.gif Antiemetic in chemotherapy-induced emesis; Antidepressant; Treatment of psychiatric conditions [sub...D02968 Drug Aprepitant (JAN/USAN/INN); Emend (TN) C23H21F7N4O3 534.1502 534.4267 D0

  7. Drug: D09024 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available D09024 Drug Totrombopag choline (USAN) C25H21N8O2. C5H14NO 569.2863 569.6574 D09024.gif Treatment of chemoth...erapy-induced thrombocytopenia, treatment of thrombocytopenia associated liver dise

  8. Drug: D01804 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available D01804 Drug Cadralazine (JP16/INN); Cadral (TN) C12H21N5O3 283.1644 283.3268 D01804...tives C02DB04 Cadralazine D01804 Cadralazine (JP16/INN) CAS: 64241-34-5 PubChem: 7848866 LigandBox: D01804

  9. Drug: D01288 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available 88 359.8466 D01288.gif Stimulant [respiratory] Same as: C12717 ATC code: R07AB08 Anatomical Therapeutic Chem...D01288 Drug Dimefline hydrochloride (JAN/USAN); Remeflin (TN) C20H21NO3. HCl 359.12

  10. SwissProt search result: AK069229 [KOME

    Lifescience Database Archive (English)

    Full Text Available AK069229 J023012H21 (O88704) Potassium/sodium hyperpolarization-activated cyclic nu...cleotide-gated channel 1 (Brain cyclic nucleotide gated channel 1) (BCNG-1) (Hyperpolarization-activated cation channel 2) (HAC-2) HCN1_MOUSE 8e-15 ...

  11. SwissProt search result: AK069229 [KOME

    Lifescience Database Archive (English)

    Full Text Available AK069229 J023012H21 (O88703) Potassium/sodium hyperpolarization-activated cyclic nu...cleotide-gated channel 2 (Brain cyclic nucleotide gated channel 2) (BCNG-2) (Hyperpolarization-activated cation channel 1) (HAC-1) HCN2_MOUSE 4e-13 ...

  12. N-Phenyladamantane-1-sulfinamide

    Directory of Open Access Journals (Sweden)

    Mrityunjoy Datta

    2008-08-01

    Full Text Available In the racemic title compound, C16H21NOS, the molecules are packed into polymeric chains in the b-axis direction and are linked along the b axis by N—H...O and C—H...O hydrogen bonds.

  13. Arabidopsis CDS blastp result: AK069229 [KOME

    Lifescience Database Archive (English)

    Full Text Available AK069229 J023012H21 At2g23980.1 cyclic nucleotide-regulated ion channel / cyclic nu...cleotide-gated channel (CNGC6) identical to cyclic nucleotide and calmodulin-regulated ion channel (cngc6) GI:4581207 from [Arabidopsis thaliana] 0.0 ...

  14. Drug: D04752 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available onatremia [selective V2-receptor antagonist] arginine vasopressin receptor 2 (AVPR2...D04752 Drug Lixivaptan (USAN/INN) C27H21ClFN3O2 473.1306 473.9259 D04752.gif Treatment of nonhypovolemic hyp

  15. Dicty_cDB: FC-AR22 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available mRNA sequence. 50 0.023 1 BU572652 |BU572652.1 PA__Ea0001H21f Almond developing seed Prunus dulcis cDNA clo...BAC, RP23-158F1, complete sequence. 48 0.092 1 BU573578 |BU573578.1 PA__Ea0004H03f Almond developing

  16. Drug: D00080 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available D00080 Drug Chondroitin sulfate A (JAN) (C14H21NO14S)n D00080.gif Same as: C00634 A...ntirheumatic agents, non-steroids M01AX25 Chondroitin sulfate D00080 Chondroitin sulfate A (JAN) CAS: 24967-

  17. Dicty_cDB: SSL755 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available map 6245135-6357017 strain AX4, complete sequence. 36 0.082 9 CA982933 |CA982933.1 AGENCOURT_11279987 Wellc...e:XL094h21, 3' end, single read. 48 0.30 1 BE506694 |BE506694.1 db85g10.y1 Wellcome CRC pSK animal cap Xenop

  18. Download this PDF file

    African Journals Online (AJOL)

    Two new minor tetranortriterpenes, 2',3'-dihydrosalannin and 1- ... H-7 in 8 and 9 were very similar to those reported for salannin (6) [6], salannol (10) [9] .... (1H, m, H-15), 6.33 (1 H, m, H-22), 7.28-7.34 (2H, m, H-21, H-23); 'QC NMR: see Table.

  19. Drug: D06552 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available D06552 Drug Alcaftadine (USAN/INN); Lastacaft (TN) C19H21N3O 307.1685 307.3895 D06552.gif Anti-allergic...03] S SENSORY ORGANS S01 OPHTHALMOLOGICALS S01G DECONGESTANTS AND ANTIALLERGICS S01GX Other antiallergics S0

  20. SwissProt search result: AK072466 [KOME

    Lifescience Database Archive (English)

    Full Text Available AK072466 J023118H21 (Q95LA2) Dimethylaniline monooxygenase [N-oxide-forming] 1 (EC ...1.14.13.8) (Hepatic flavin-containing monooxygenase 1) (FMO 1) (Dimethylaniline oxidase 1) FMO1_CANFA 3e-14 ...

  1. SwissProt search result: AK072466 [KOME

    Lifescience Database Archive (English)

    Full Text Available AK072466 J023118H21 (Q8K4C0) Dimethylaniline monooxygenase [N-oxide-forming] 5 (EC ...1.14.13.8) (Hepatic flavin-containing monooxygenase 5) (FMO 5) (Dimethylaniline oxidase 5) FMO5_RAT 7e-17 ...

  2. SwissProt search result: AK072466 [KOME

    Lifescience Database Archive (English)

    Full Text Available AK072466 J023118H21 (P17635) Dimethylaniline monooxygenase [N-oxide-forming] 2 (EC ...1.14.13.8) (Pulmonary flavin-containing monooxygenase 2) (FMO 2) (Dimethylaniline oxidase 2) (FMO 1B1) FMO2_RABIT 1e-15 ...

  3. SwissProt search result: AK072466 [KOME

    Lifescience Database Archive (English)

    Full Text Available AK072466 J023118H21 (P50285) Dimethylaniline monooxygenase [N-oxide-forming] 1 (EC ...1.14.13.8) (Hepatic flavin-containing monooxygenase 1) (FMO 1) (Dimethylaniline oxidase 1) FMO1_MOUSE 2e-12 ...

  4. SwissProt search result: AK072466 [KOME

    Lifescience Database Archive (English)

    Full Text Available AK072466 J023118H21 (Q8HZ70) Dimethylaniline monooxygenase [N-oxide-forming] 2 (EC ...1.14.13.8) (Pulmonary flavin-containing monooxygenase 2) (FMO 2) (Dimethylaniline oxidase 2) (FMO 1B1) FMO2_PANTR 9e-18 ...

  5. Drug: D07454 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available D07454 Drug Amylocaine (BAN) C14H21NO2 235.1572 235.322 D07454.gif Local anesthetic... Same as: C14169 map07015 Local analgesics CAS: 644-26-8 PubChem: 51091785 LigandBox: D07454 NIKKAJI: J13.80

  6. SwissProt search result: AK072740 [KOME

    Lifescience Database Archive (English)

    Full Text Available AK072740 J023134H21 (Q93WU2) Eugenol O-methyltransferase (EC 2.1.1.146) ((Iso)eugenol... O-methyltransferase EOMT1) (S-adenosysl-L-methionine:(Iso)eugenol O-methyltransferase EOMT1) EOMT1_OCIBA 3e-67 ...

  7. SwissProt search result: AK072740 [KOME

    Lifescience Database Archive (English)

    Full Text Available AK072740 J023134H21 (Q93WU3) Chavicol O-methyltransferase (EC 2.1.1.146) ((Iso)eugenol... O-methyltransferase CVOMT1) (S-adenosysl-L-methionine:(Iso)eugenol O-methyltransferase CVOMT1) CVMT1_OCIBA 3e-65 ...

  8. Drug: D01383 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available (TN) C15H21NO2. HCl 283.1339 283.7937 D01383.gif Analgesic [narcotic] Therapeutic category: 8211 ATC code: ...idine hydrochloride (JP16); Meperidine hydrochloride (USP) USP drug classification [BR:br08302] Analgesics Opioid Analgesic

  9. Drug: D05312 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available D05312 Drug Oxycodone (USAN/INN) C18H21NO4 315.1471 315.3636 D05312.gif Analgesic [...ds N02AA05 Oxycodone D05312 Oxycodone (USAN/INN) USP drug classification [BR:br08302] Analgesics Opioid Analgesic...s, Long-acting Oxycodone D05312 Oxycodone (USAN/INN) Opioid Analgesics, Shor

  10. Drug: D01599 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available D01599 Drug Gliclazide (JP16/INN); Glimicron (TN) C15H21N3O3S 323.1304 323.4105 D01599.gif Antidiabetic...ents affecting metabolism 396 Antidiabetic agents 3961 Sulfonylureas D01599 Glicl

  11. Drug: D00379 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available D00379 Drug Tolazamide (JP16/USP/INN); Tolinase (TN) C14H21N3O3S 311.1304 311.3998 D00379.gif Antidiabetic...od Glucose Regulators Antidiabetic Agents Tolazamide D00379 Tolazamide (JP16/USP/INN) Target-based classific

  12. Drug: D10200 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available D10200 Drug Ipragliflozin L-proline (JAN) C21H21FO5S. C5H9NO2 519.1727 519.5823 D10200.gif Antidiabetic... [DS:H00409] sodium glucose co-transporter2 (SGLT2) inhibitor [HSA:6524] [KO:K14382] map07051 Antidiabetic

  13. SwissProt search result: AK072740 [KOME

    Lifescience Database Archive (English)

    Full Text Available AK072740 J023134H21 (Q9LEL5) 3'-hydroxy-N-methyl-(S)-coclaurine 4'-O-methyltransfer...ase (EC 2.1.1.116) (S-adenosyl-L-methionine:3'-hydroxy-N-methylcoclaurine 4'-O-methyltransferase) (4'-OMT) 4OMT_COPJA 3e-44 ...

  14. (E-N′-[4-(Dimethylaminobenzylidene]-2-(4-methylphenoxyacetohydrazide

    Directory of Open Access Journals (Sweden)

    M. K. Usha

    2014-02-01

    Full Text Available In the title compound, C18H21N3O2, the dihedral angle between the benzene rings is 68.85 (11°. In the crystal, the molecules are linked by C—H...O and N—H...O hydrogen bonds, as well as weak C—H...π contacts, forming a three-dimensional supramolecular architecture.

  15. Arabidopsis CDS blastp result: AK067891 [KOME

    Lifescience Database Archive (English)

    Full Text Available AK067891 J013124H21 At4g22260.1 alternative oxidase, putative / immutans protein (I...M) identical to IMMUTANS from Arabidopsis thaliana [gi:4138855]; contains Pfam profile PF01786 alternative oxidase 1e-110 ...

  16. Drug: D07872 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available D07872 Drug Dosulepin (INN); Dothiepin; Dothep (TN) C19H21NS 295.1395 295.4417 D07872.gif Antidepress...ant, trycyclic ATC code: N06AA16 Tricyclic antidepressants serotonin transporter inhibitor... [HSA:6532] [KO:K05037]; noradrenalin transporter inhibitor [HSA:6530] [KO:K05035] map07027 Antidepressants

  17. Chlorido{N-[(diethylamino)dimethylsilyl]anilido-κN}(N,N,N′,N′-tetramethylethane-1,2-diamine-κ2N,N′)iron(II)

    National Research Council Canada - National Science Library

    Chen, Juan

    2012-01-01

    In the title iron(II) complex, [Fe(C12H21N2Si)Cl(C6H16N2)], the FeII cation is coordinated by two N atoms from the tetramethylethane-1,2-diamine ligand [Fe—N = 2.191 (5) and 2.215 (4) Å...

  18. EST Table: FY018488 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available FY018488 rbmov22h21 11/11/04 97 %/265 aa ref|NP_001040121.1| endothelial-monocyte a...ctivating polypeptide II [Bombyx mori] gb|ABD36113.1| endothelial-monocyte activating polypeptide II [Bombyx

  19. EST Table: FY007658 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available FY007658 bmov22h21 11/11/04 100 %/199 aa ref|NP_001040121.1| endothelial-monocyte a...ctivating polypeptide II [Bombyx mori] gb|ABD36113.1| endothelial-monocyte activating polypeptide II [Bombyx

  20. Drug: D06632 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available , major depression, and schizophrenia 5-HT2A-receptor antagonist [HSA:3356] [KO:K04157] hsa04020(3356) Calci...D06632 Drug Pruvanserin (USAN/INN) C22H21FN4O 376.1699 376.4267 D06632.gif Insomnia

  1. DNA binding sites recognised in vitro by a knotted class 1 homeodomain protein encoded by the hooded gene, k, in barley (Hordeum vulgare)

    DEFF Research Database (Denmark)

    Krusell, L; Rasmussen, I; Gausing, K

    1997-01-01

    of knotted1 from maize was isolated from barley seedlings and expressed as a maltose binding protein fusion in E. coli. The purified HvH21-fusion protein selected DNA fragments with 1-3 copies of the sequence TGAC. Gel shift experiments showed that the TGAC element was required for binding and the results...

  2. Dicty_cDB: Contig-U04752-1 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available erti... 44 8.5 1 ( EL432776 ) CHCS7140.b1_G10.ab1 CHC(LMS) Texas blueweed Helia...... 44 8.5 1 ( EL431134 ) CHCS564.b1_H21.ab1 CHC(LMS) Texas blueweed Helian... 44 8.5 1 ( DR108760 ) USDA-FP_1

  3. Dicty_cDB: Contig-U15987-1 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available 58 ) CHCL6708.b1_H21.ab1 CHC(LMS) Texas blueweed Helia... 50 0.18 1 ( EH497612 ) FDR107-P00039-DEPE-F_G10 FD...d CBHI Metridium senile tentacle Metri... 38 0.68 2 ( EL418567 ) CHCL6991.b1_M19.ab1 CHC(LMS) Texas blueweed

  4. SwissProt search result: AK070181 [KOME

    Lifescience Database Archive (English)

    Full Text Available AK070181 J023043H21 (P09095) Tyrocidine synthetase I [Includes: ATP-dependent D-phenylala...nine adenylase (D-PheA) (D-phenylalanine activase); Phenylalanine racemase [ATP-hydrolyzing] (EC 5.1.1.11)] TYCA_BREPA 2e-19 ...

  5. (E-2,2′-[3-(2-Nitrophenylprop-2-ene-1,1-diyl]bis(3-hydroxycyclohex-2-en-1-one

    Directory of Open Access Journals (Sweden)

    Joo Hwan Cha

    2012-01-01

    Full Text Available In the title compound, C21H21NO6, each of the cyclohexenone rings adopts a half-chair conformation. Each of the pairs of hydroxy and carbonyl O atoms are oriented to allow for the formation of intramolecular O—H...O hydrogen bonds, which are typical of xanthene derivatives.

  6. 1-(Adamantan-1-yl-3-(4-fluorophenylthiourea

    Directory of Open Access Journals (Sweden)

    Nasser R. El-Brollosy

    2012-05-01

    Full Text Available In the title molecule, C17H21FN2S, the mean planes of the benzene ring and the thiourea fragment form a dihedral angle of 61.93 (9°. In the crystal, pairs of weak N—H...S interactions link the molecules, forming inversion dimers.

  7. Sumoylation Inhibits the Growth Suppressive Properties of Ikaros.

    Directory of Open Access Journals (Sweden)

    Apostol Apostolov

    Full Text Available The Ikaros transcription factor is a tumor suppressor that is also important for lymphocyte development. How post-translational modifications influence Ikaros function remains partially understood. We show that Ikaros undergoes sumoylation in developing T cells that correspond to mono-, bi- or poly-sumoylation by SUMO1 and/or SUMO2/3 on three lysine residues (K58, K240 and K425. Sumoylation occurs in the nucleus and requires DNA binding by Ikaros. Sumoylated Ikaros is less effective than unsumoylated forms at inhibiting the expansion of murine leukemic cells, and Ikaros sumoylation is abundant in human B-cell acute lymphoblastic leukemic cells, but not in healthy peripheral blood leukocytes. Our results suggest that sumoylation may be important in modulating the tumor suppressor function of Ikaros.

  8. Identification of amino acid residues involved in the interaction between measles virus Haemagglutin (MVH) and its human cell receptor (signaling lymphocyte activation molecule, SLAM).

    Science.gov (United States)

    Xu, Qin; Zhang, Peng; Hu, Chunling; Liu, Xin; Qi, Yipeng; Liu, Yingle

    2006-07-31

    Signaling lymphocyte activation molecule (SLAM; also known as CD150) is a newly identified cellular receptor for measles virus (MV). The interaction between MV Haemagglutin (MVH) and SLAM is an initial step for MV entry. We have identified several novel SLAM binding sites at residues S429, T436 and H437 of MVH protein and MVH mutants in these residues dramatically decrease the ability to interaction with the cell surface SLAM and fail to coprecipitation with SLAM in vivo as well as malfunction in syncytium formation. At the same time, K58, S59 and H61 of SLAM was also identified to be critical for MVH and SLAM binding. Further, these residues may be useful targets for the development of measles therapy.

  9. Angular momentum and topological dependence of Kepler's Third Law in the Broucke-Hadjidemetriou-H\\'enon family of periodic three-body orbits

    CERN Document Server

    Janković, Marija R

    2016-01-01

    We use 57 recently found topological satellites of Broucke-Hadjidemetriou-Henon's periodic orbits with values of the topological exponent $k$ ranging from $k$ = 3 to $k$ = 58 to plot the angular momentum $L$ as a function of the period $T$, with both $L$ and $T$ rescaled to energy $E=-\\frac12$. Upon plotting $L(T/k)$ we find that all our solutions fall on a curve that is virtually indiscernible by naked eye from the $L(T)$ curve for non-satellite solutions. The standard deviation of the satellite data from the sixth-order polynomial fit to the progenitor data is $\\sigma = 0.13$. This regularity supports Henon's 1976 conjecture that the linearly stable Broucke-Hadjidemetriou-Henon orbits are also perpetually, or Kolmogorov-Arnold-Moser stable.

  10. Hydrogenation/Dehydrogenation Performances of the MgH2-WS2 Composites

    Institute of Scientific and Technical Information of China (English)

    WANG Jiasheng; ZHANG Wei; CHENG Ying; KE Dandan; HAN Shumin

    2015-01-01

    The hydrogenation/dehydrogenation kinetics and thermodynamic behaviors of the MgH2-WS2 composites were investigated. The TPD (Temperature-Programmed-Desorption) curves showed that the onset dehydrogenation temperature of the MgH2 + 20wt% WS2 composite was 615 K, 58 K lower than that of the pristine MgH2. The kinetic measurements showed that within 21 min, the MgH2 + 20wt% WS2 composite could absorb 2.818wt% at 423 K, and release 4.244 wt% of hydrogen at 623 K, while the hydriding/dehydriding capacity of MgH2 reached only 0.979wt% and 2.319wt% respectively under identical conditions. The improvement of hydrogenation/dehydrogenation performances for the composite was attributed to the co-catalytic effect between the new phases W and MgS which formed during the ball-milling process.

  11. Synthesis and Characterization of 8-Hydroxyquinoline Derivative Containing a Triphenylamine Unit and Its Metal Complexes

    Institute of Scientific and Technical Information of China (English)

    JING, Hui-Lian; ZENG, He-Ping; ZHOU, Ya-Dong; WANG, Ting-Ting; YUAN, Guo-Zan; OUYANG, Xin-Hua

    2006-01-01

    A new 8-hydroxyquinoline derivative (5) was synthesized and characterized by ESI-MS, 1H NMR spectroscopy,elemental analysis and IR spectroscopy. The photophysical properties of compounds 5, 6 and 7 were also detemined by UV-vis and FL spectroscopy. The vibrational frequency of ligand 5 predicted by using B3LYP method is in good agreement with experimentally determined values. The compositions of the corresponding copper(Ⅱ) and zinc(Ⅱ)complexes were confirmed to be Cu(C29H21N2O)2·H2O (6) and Zn(C29H21N2O)2·H2O (7) by elementary analysis,thermogravimetry analysis and IR spectroscopy.

  12. Dicty_cDB: AFK120 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available 1.yg.ab1 QG_ABCDI lettuce salinas Lactuca sativa cDNA clone QGC16K01, mRNA sequence. 54 3e-05 2 BQ862793 |BQ...862793.1 QGC22B11.yg.ab1 QG_ABCDI lettuce salinas Lactuca sativa cDNA clone QGC22...B11, mRNA sequence. 54 3e-05 2 BQ864368 |BQ864368.1 QGC26H21.yg.ab1 QG_ABCDI lettuce salinas Lactuca sativa ...cDNA clone QGC26H21, mRNA sequence. 54 3e-05 2 BQ861698 |BQ861698.1 QGC19F15.yg.ab1 QG_ABCDI lettuce salinas

  13. Dicty_cDB: SFE493 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available 6K01.yg.ab1 QG_ABCDI lettuce salinas Lactuca sativa cDNA clone QGC16K01, mRNA seq...uence. 54 3e-09 3 BQ862793 |BQ862793.1 QGC22B11.yg.ab1 QG_ABCDI lettuce salinas Lactuca sativa cDNA clone QG...C22B11, mRNA sequence. 54 3e-09 3 BQ864368 |BQ864368.1 QGC26H21.yg.ab1 QG_ABCDI lettuce salinas Lactuca sati...g.ab1 QG_ABCDI lettuce salinas Lactuca sativa cDNA clone QGC19F15, mRNA sequence. 54 3e-09 3 BW191896 |BW191...va cDNA clone QGC26H21, mRNA sequence. 54 3e-09 3 BQ861698 |BQ861698.1 QGC19F15.y

  14. Vibrational Spectra of 3-(Adamantan-1-YL)-4-(2-Propen-1-YL)-1 H-1,2,4-Triazole-5(4 H)-Thione

    Science.gov (United States)

    Gladkov, L. L.; Matsukovich, A. S.; Pavich, T. A.; Gaponenko, S. V.; El-Emam, A. A.

    2017-01-01

    Vibrational spectra of 3-(adamantan-1-yl)-4-(2-propen-1-yl)-1H-1,2,4-triazole-5(4H)-thione (C15H21N3S), which was promising for drug development, were studied experimentally and theoretically. The geometric structure and normal modes of the molecule and its dimer were calculated using quantum-mechanical density functional theory. It was shown that the experimentally obtained vibrational spectra were due to dimeric C15H21N3S structures. This conclusion was confirmed by spectra of the isotopically substituted compound with a deuterated imine. Bands at 1496 and 1549 cm-1 were identified as markers of dimer formation. Bands at 936 and 1244 cm-1 were found to be markers of intermolecular interactions of adamantane fragments.

  15. Two One-Parameter Special Geometries

    CERN Document Server

    Braun, Volker; de la Ossa, Xenia

    2015-01-01

    The special geometries of two recently discovered Calabi-Yau threefolds with $h^{11}=1$ are analyzed in detail. These correspond to the 'minimal three-generation' manifolds with $h^{21}=4$ and the `24-cell' threefolds with $h^{21}=1$. It turns out that the one-dimensional complex structure moduli spaces for these manifolds are both very similar and surprisingly complicated. Both have 6 hyperconifold points and, in addition, there are singularities of the Picard-Fuchs equation where the threefold is smooth but the Yukawa coupling vanishes. Their fundamental periods are the generating functions of lattice walks, and we use this fact to explain why the singularities are all at real values of the complex structure.

  16. Subsolidus binary phase diagram of C10Zn-C18Zn of thermotropic phase transitions materials

    Institute of Scientific and Technical Information of China (English)

    武克忠; 王新东; 刘晓地; 左萍

    2004-01-01

    The thermotropic phase transitions layer compound in the perovskite type (n-C10 H21 NH3 )2 ZnCl4 and (nC18 H37 NH3 )2 ZnCl4 were synthesized and, at the same time, a series of rnixtures C10 Zn/C18 Zn were prepared. The experimental binary phase diagram of C10 Zn/C18 Zn was established by means of differential scanning calorimetry (DSC) and X-ray diffraction. In the phase diagram, compound (n-C10 H21 NH3 ) (n-C21 H37 NH3 )ZnCl4 and two eutectoid invariants were observed; two eutectoid temperatures are about 53 ℃ and 58 ℃. Contrasting with other similar systems, there are three noticeable solid solution ranges at the left and right boundary and middle of the phase diagram.

  17. The Voronoi Diagram for the Euclidean Traveling Salesman Problem Is Piecemeal Quartic and Hyperbolic

    Science.gov (United States)

    1990-06-01

    ceiling function is of cubic order as predicted by the analysis. Acknowledgments The research has greatly benefited from discussions with Gerald ...The Science of Computing. Exploring tole Nature and Power of Algorithms. Addison-Wesley. Reading MA. � 1989 [H21 Held, M . and R M Karp , "The...34Traveling salesman cycles are not always subgrapris of Voronoi duals", Information Processing .etters 16(l):11-12. January 1983. (K21 Karp , R.M

  18. Drug: D08247 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available D08247 Drug Nalorphine (INN); Nalorphine serb (TN) C19H21NO3 311.1521 311.3749 D08247...Antidotes V03AB02 Nalorphine D08247 Nalorphine (INN) Target-based classification of drugs [BR:br08310] G Pro...K04215] Nalorphine [ATC:V03AB02] D08247 Nalorphine (INN) CAS: 62-67-9 PubChem: 96024935 LigandBox: D08247 NI

  19. Drug: D02476 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available D02476 Drug Meclocycline (USAN/INN) C22H21ClN2O8 476.0986 476.8637 D02476.gif Antib... of acne D10AF04 Meclocycline D02476 Meclocycline (USAN/INN) Antiinfectives [BR:b...] Tetracyclines Meclocycline [ATC:D10AF04] D02476 Meclocycline (USAN/INN) CAS: 2013-58-3 PubChem: 7849531 LigandBox: D0247

  20. Drug: D10196 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available D10196 Drug Ipragliflozin (INN) C21H21FO5S 404.1094 404.4518 D10196.gif Antidiabeti... Target-based classification of drugs [BR:br08310] Transporters Solute carrier family SLC5 SLC5A2 [HSA:6524] [KO:K14382] Ipragliflozi...n D10196 Ipragliflozin (INN) CAS: 761423-87-4 PubChem: 1

  1. 30 aastat pärast diktatuuri hukku pole rahu Hispaaniasse naasnud / Priit Kivi

    Index Scriptorium Estoniae

    Kivi, Priit

    2005-01-01

    Ilmunud ka: Postimees : na russkom jazõke Ajal. Postimees : na russkom jazõke lüh. 21. nov., lk 11. Hispaania paremäärmuslased süüdistavad sotsialistlikku valitsust riigi tahtlikus lõhkumises. Franco-kummardajate terava vastuseisu on pälvinud valitsuse toetus samasooliste abielule, Kataloonia iseseisvuspüüdluste toetamine ning planeeritav õppekava, mis vähendab usuõpetuse tähtsust koolides. Lisa: Kindral Francisco Franco

  2. Drug: D07642 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available D07642 Drug Cefminox (INN); CMNX C16H21N7O7S3 519.0665 519.5756 D07642.gif Antibiotic, cephalosporin... ATC code: J01DC12 Semisynthetic cephalosporin: broad spectrum cephalosporin penicillin bin... SYSTEMIC USE J01 ANTIBACTERIALS FOR SYSTEMIC USE J01D OTHER BETA-LACTAM ANTIBACTERIALS J01DC Second-generation cephalosporin

  3. (2,6-Diisopropyl-phen-yl)(2-thienylmethyl-ene)amine.

    Science.gov (United States)

    Imhof, Wolfgang

    2009-02-25

    The title compound, C(17)H(21)NS, was prepared by the condensation of thio-phene-2-carbaldehyde with 2,6-diiso-propyl-aniline. It crystallizes with two mol-ecules in the asymmetric unit. The mol-ecules are inter-connected via a C-H⋯N hydrogen bond. The dihedral angles between the thio-phene and phenyl rings are 81.7 (7) and 85.5 (7)°.

  4. Spectroscopic investigation of phase transitions in 1-nonanol and 1-decanol

    CERN Document Server

    Chernolevska, Yelyzaveta; Pogorelov, Valeriy; Doroshenko, Iryna; Doroshenko, Olena; Sablinskas, Valdas; Balevicius, Vytautas

    2016-01-01

    FTIR spectra of monohydric alcohols 1-nonanol (C9H19OH) and 1-decanol (C10H21OH) were registered in the spectral region from 500 cm-1 to 4000 cm-1 at temperatures from -50 to + 25 {\\deg}C for 1-nonanol and +100 {\\deg}C for 1-decanol. Temperature-induced spectra changes were compared for these two alcohols. The authors link the observed changes with the transformations of cluster structure occurring during phase transitions.

  5. Crystal structure of bis[S-hexyl 3-(4-methylbenzylidenedithiocarbazato-κ2N3,S]nickel(II

    Directory of Open Access Journals (Sweden)

    M. B. H. Howlader

    2015-02-01

    Full Text Available In the title complex, [Ni(C15H21N2S22], the NiII atom exhibits a square-planar coordination geometry and is located on an inversion centre leading to a trans configuration of the N,S-chelating ligands. In the crystal, the complex molecules stack at a distance of 4.6738 (3 Å along the a axis, which exclude any significant interactions between the aromatic rings.

  6. Drug: D08174 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available D08174 Drug Memantine (INN); Exiba (TN) C12H21N 179.1674 179.3018 D08174.gif Anti-Alzheimer...'s [DS:H00056] Same as: C13736 ATC code: N06DX01 Indication: Alzheimer's disease adamantane derivati...napse hsa05010(2902+2903+2904+2905+2906) Alzheimer's disease Transporter: SLC22A2 [HSA:6582] map07056 Agents for Alzheimer

  7. Drug: D01297 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available D01297 Drug Pirenzepine hydrochloride (USAN) C19H21N5O2. 2HCl 423.1229 424.3242 D01...pine D01297 Pirenzepine hydrochloride (USAN) Target-based classification of drugs [...eceptor M1 [HSA:1128] [KO:K04129] Pirenzepine [ATC:A02BX03] D01297 Pirenzepine hy...ASE (GORD) A02BX Other drugs for peptic ulcer and gastro-oesophageal reflux disease (GORD) A02BX03 Pirenze

  8. Drug: D08389 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available D08389 Drug Pirenzepine (INN) C19H21N5O2 351.1695 351.4023 D08389.gif Gastric secre...x disease (GORD) A02BX03 Pirenzepine D08389 Pirenzepine (INN) Target-based classification of drugs [BR:br083...M1 [HSA:1128] [KO:K04129] Pirenzepine [ATC:A02BX03] D08389 Pirenzepine (INN) CAS:

  9. Drug: D00822 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available D00822 Drug Citalopram hydrobromide (USAN); Celexa (TN) C20H21FN2O. HBr 404.09 405....06AB Selective serotonin reuptake inhibitors N06AB04 Citalopram D00822 Citalopram hydrobromide (USAN) USP dr...n and Norepinephrine Reuptake Inhibitors) Citalopram D00822 Citalopram hydrobromi...serotonin transporter) [HSA:6532] [KO:K05037] Citalopram [ATC:N06AB04] D00822 Citalopram hydrobromide (USAN)

  10. Drug: D10171 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available D10171 Drug Tedatioxetine hydrobromide (USAN) C18H21NS. HBr 363.0656 364.343 D10171...-receptor [HSA:3358] [KO:K04157] Tedatioxetine D10171 Tedatioxetine hydrobromide (USAN) 5-HT3-receptor [HSA:...3359 9177 170572 200909 285242] [KO:K04819] Tedatioxetine D10171 Tedatioxetine hydrobromide... [KO:K08155] [TC:2.A.1.2.29] Tedatioxetine D10171 Tedatioxetine hydrobromide (USAN) CAS: 960151-65-9 PubChem

  11. Drug: D01879 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available D01879 Drug Eptazocine hydrobromide (JAN); Sedapain (TN) C15H21NO. HBr 311.0885 312...l nervous system 114 Antipyretics and analgesics, anti-inflammatory agents 1149 Others D01879 Eptazocine hydrobromide...ed receptors Rhodopsin family Opioid mu-opioid receptor [HSA:4988] [KO:K04215] Eptazocine D01879 Eptazocine hydrobromide... (JAN) kappa-opioid receptor [HSA:4986] [KO:K04214] Eptazocine D01879 Eptazocine hydrobromide (J

  12. Crystal structure of 5-chloro-3-cyclohexylsulfinyl-2,4,6-trimethyl-1-benzofuran

    Directory of Open Access Journals (Sweden)

    Hong Dae Choi

    2014-09-01

    Full Text Available In the title compound, C17H21ClO2S, the cyclohexyl ring adopts a chair conformation with the C—S bond in an equatorial orientation. In the crystal, molecules are linked by C—H...O and C—H...π hydrogen bonds and a Cl...π [3.594 (2 Å] contact into chains along the a-axis direction.

  13. 5-Cyclohexyl-2-(3-fluorophenyl-3-methylsulfinyl-1-benzofuran

    Directory of Open Access Journals (Sweden)

    Hong Dae Choi

    2012-04-01

    Full Text Available In the title compound, C21H21FO2S, the cyclohexyl ring adopts a chair conformation. The 3-fluorophenyl ring makes a dihedral angle of 38.38 (6° with the mean plane [r.m.s. deviation = 0.010 (1 Å] of the benzofuran fragment. In the crystal, molecules are linked by weak C—H...O hydrogen bonds.

  14. 2-[(1RS,3RS,3aRS,6aSR-5-Benzyl-4,6-dioxo-3-phenyloctahydropyrrolo[3,4-c]pyrrol-1-yl]acetamide

    Directory of Open Access Journals (Sweden)

    Konstantin V. Kudryavtsev

    2011-12-01

    Full Text Available In the title compound, C21H21N3O3, the relative stereochemistry of the four stereogenic C atoms has been determined. The dihedral angle between the phenyl rings is 77.63 (7°. In the crystal, ribbons spread along the a axis are formed by N—H...O hydrogen bonds. C—H...π interactions also occur.

  15. Dicty_cDB: AFK872 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available ACR23H21, complete sequence. 42 0.051 6 AI484136 |AI484136.1 EST248943 tomato resistant, Cornell Lycopersico...12 2 AI490786 |AI490786.1 EST241494 tomato shoot, Cornell Lycopersicon esculentum cDNA clone cLEB3H9 similar... AI773934 |AI773934.1 EST255034 tomato resistant, Cornell Lycopersicon esculentum cDNA clone cLER8N1, mRNA s

  16. Dicty_cDB: CFG834 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available one BACR23H21, complete sequence. 42 0.038 6 AI484136 |AI484136.1 EST248943 tomato resistant, Cornell Lycope...38 0.10 2 AI490786 |AI490786.1 EST241494 tomato shoot, Cornell Lycopersicon esculentum cDNA clone cLEB3H9 si....10 2 AI773934 |AI773934.1 EST255034 tomato resistant, Cornell Lycopersicon esculentum cDNA clone cLER8N1, m

  17. Dicty_cDB: SSH878 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available M library Mus musculus genomic clone UUGC1M0399K06 R, DNA sequence. 48 0.076 1 BU572652 |BU572652.1 PA__Ea0001H21f Almond developing...nce. 48 0.076 1 BU573578 |BU573578.1 PA__Ea0004H03f Almond developing seed Prunus dulcis cDNA clone PA__Ea00

  18. Dicty_cDB: FC-IC0858 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available AC, RP23-158F1, complete sequence. 48 0.060 1 BU572652 |BU572652.1 PA__Ea0001H21f Almond developing...6.1 Lupinus luteus mRNA for ribosomal protein L30. 48 0.060 1 BU573578 |BU573578.1 PA__Ea0004H03f Almond developing

  19. Drug: D06303 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available D06303 Drug Vincofos (USAN/INN) C11H21Cl2O4P 318.0555 319.1618 D06303.gif Anthelmin...tic CAS: 17196-88-2 PubChem: 47207960 LigandBox: D06303 NIKKAJI: J9.078F ATOM 18 1 C1b C 21.2292 -17.8938 2

  20. Heavyweight Dendritic Inks for Positive Microcontact Printing

    NARCIS (Netherlands)

    Perl, András; Peter, Mária; Ravoo, Bart Jan; Reinhoudt, David N.; Huskens, Jurriaan

    2006-01-01

    Poly(propylene imine) dendrimers with dialkyl sulfide end groups were prepared and developed as inks for positive microcontact printing ((+)uCP) on gold. Long (C10H21-S-C10H20-), medium (C3H7-S-C4H8-), and short (CH3-S-CH2-) dialkyl sulfide end groups were attached to second- and third-generation PP

  1. Bromido(2-{1-[2-(piperidin-1-ylethylimino]ethyl}phenolatocopper(II

    Directory of Open Access Journals (Sweden)

    Xiao-Fan Zhao

    2010-08-01

    Full Text Available In the title complex, [CuBr(C15H21N2O], the CuII atom is coordinated by one phenolate O, one imine N and one amine N atom of the tridentate Schiff base ligand and by one bromide ion, resulting in a distorted CuBrN2O square-planar geometry for the metal ion, with the N atoms in a cis conformation.

  2. Drug: D00847 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available (TN) C18H21NO4. HCl 351.1237 351.8246 D00847.gif Analgesic [narcotic] Same as: C08026 ATC code: N02AA05 mu-o...ide (USP) USP drug classification [BR:br08302] Analgesics Opioid Analgesics, Long...-acting Oxycodone D00847 Oxycodone hydrochloride (USP) Opioid Analgesics, Short-acting Oxycodone D00847 Oxyc

  3. Early Attachment Sites for Shiga-toxigenic Escherichia coli O157:H7 in Experimentally Inoculated Weaned Calves

    Science.gov (United States)

    Weaned 3-to- 4-month-old calves were fasted 48 h, inoculated with 10**10 CFU of Shiga toxin-positive Escherichia coli (STEC) O157:H7 strain 86-24 (STEC O157) or STEC O91:H21 strain B2F1 (STEC O91), Shiga toxin-negative E. coli O157:H7 strain 87-23 (Stx**- O157), or non-pathogenic control E. coli, ne...

  4. Drug: D01665 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available D01665 Drug Voglibose (JP16/USAN/INN); Basen (TN) C10H21NO7 267.1318 267.2762 D01665.gif Antidiabetic...se metabolism hsa04973(8972) Carbohydrate digestion and absorption map07051 Antidiabetics Therapeutic catego...ry of drugs in Japan [BR:br08301] 3 Agents affecting metabolism 39 Other agents affecting metabolism 396 Antidiabetic

  5. Drug: D10112 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available D10112 Drug Dexmecamylamine hydrochloride (USAN) C11H21N. HCl 203.1441 203.7521 D10112.gif Treatment of major depressive disorder nicotinic cholinergic receptor alpha4beta2 antagonist [HSA:11...04813] Dexmecamylamine D10112 Dexmecamylamine hydrochloride (USAN) CAS: 107596-30-5 PubChem: 135626830 LigandBox: D1011...s Cys-loop superfamily Acetylcholine (nicotinic) alpha4beta2 nicotinic receptor [HSA:1137 1141] [KO:K04806 K

  6. Drug: D10111 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available D10111 Drug Dexmecamylamine (USAN) C11H21N 167.1674 167.2911 D10111.gif Treatment o...ily Acetylcholine (nicotinic) alpha4beta2 nicotinic receptor [HSA:1137 1141] [KO:K04806 K04813] Dexmecamylamine D1011...1 Dexmecamylamine (USAN) CAS: 107538-05-6 PubChem: 135626829 LigandBox: D10111 ATOM 12 1 C1z C 25.1

  7. Drug: D09324 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available D09324 Drug Bederocin (USAN/INN) C20H21BrFN3OS 449.0573 450.3676 D09324.gif Antibac...ntiinfectives [BR:br08307] Antibacterials Protein biosynthesis inhibitor methionyl-tRNA synthetase (MetRS) inhibitor [KO:K01874] Bed...erocin D09324 Bederocin (USAN/INN) CAS: 757942-43-1 PubCh

  8. 2-[5-(4-Methoxyphenyl-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl]-6-methyl-1,3-benzothiazole

    Directory of Open Access Journals (Sweden)

    Hoong-Kun Fun

    2011-09-01

    Full Text Available In the title compound, C24H21N3OS, the pyrazole ring makes dihedral angles of 5.40 (7 and 6.72 (8° with the benzo[d]thiazole ring system and the benzene ring, respectively, and a dihedral angle of 85.72 (8° with the methoxy-substituted benzene ring. In the crystal structure, the molecules are linked by C—H...π interactions.

  9. Drug: D00315 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available D00315 Drug Etodolac (JP16/USP/INN); Lodine (TN) C17H21NO3 287.1521 287.3535 D00315.gif Anti-inflammatory... USP drug classification [BR:br08302] Analgesics Nonsteroidal Anti-inflammatory D...rugs Etodolac D00315 Etodolac (JP16/USP/INN) Anti-inflammatory Agents Nonsteroidal Anti-inflammatory Drugs E

  10. Drug: D08343 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available st [HSA:4988] [KO:K04215] hsa04080(4988) Neuroactive ligand-receptor interaction map07028 Antipsychotics map07039 Opioid analgesic...3327 D08343.gif Opioid analgesic Same as: C07128 ATC code: N02AB02 Synthesis opioid mu-opioid receptor agoni...D08343 Drug Pethidine (INN); Meperidine; Pethidine DBL (TN) C15H21NO2 247.1572 247.

  11. Drug: D01208 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available D01208 Drug Aluminum clofibrate (JAN/INN); Alfibrate (TN) C20H21AlCl2O7 470.048 471...GENTS C10A LIPID MODIFYING AGENTS, PLAIN C10AB Fibrates C10AB03 Aluminium clofibrate D01208 Aluminum clofibr...tivated receptor (PPAR) alpha [HSA:5465] [KO:K07294] Aluminium clofibrate [ATC:C10AB03] D01208 Aluminum clof

  12. (Isopropylamino(methyldiphenylphosphonium iodide

    Directory of Open Access Journals (Sweden)

    Normen Peulecke

    2011-07-01

    Full Text Available The title compound, C16H21NP+·I−, was obtained by the reaction of Ph2PN(iPrP(PhN(iPrH with MeI involving cleavage of one of the P—N bonds in diethyl ether. The two phenyl rings form a dihedral angle of 82.98 (5°. A weak donor–acceptor N—H...I interaction is observed.

  13. Drug: D08288 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available D08288 Drug Nortriptyline (INN); Nortrilen (TN) C19H21N 263.1674 263.3767 D08288.gif Antidepress...ant, tricyclic Same as: C07274 ATC code: N06AA10 Tricyclic antidepressants serotonin transporte... Serotonergic synapse Enzyme: CYP2D6 [HSA:1565] Genomic biomarker: CYP2D6 [HSA:1565] map07027 Antidepress... D08288 Nortriptyline (INN) USP drug classification [BR:br08302] Antidepressants Tricyclics Nortriptyline D0

  14. Drug: D08124 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available D08124 Drug Levosalbutamol (INN) C13H21NO3 239.1521 239.3107 D08124.gif Antiasthmat...onists R03AC02 Salbutamol D08124 Levosalbutamol (INN) R03C ADRENERGICS FOR SYSTEM...IC USE R03CC Selective beta-2-adrenoreceptor agonists R03CC02 Salbutamol D08124 Levosalbutamol (INN) Target-...energic receptor [HSA:154] [KO:K04142] Levosalbutamol D08124 Levosalbutamol (INN)

  15. Drug: D06656 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available D06656 Drug Tezampanel (USAN); Tezampanel hydrate C13H21N5O2. H2O 297.1801 297.3534... receptor [HSA:2897 2898 2899 2900 2901] [KO:K05201 K05202 K05203 K05204 K05205] Tezampanel D06656 Tezampanel... (USAN) AMPA receptor [HSA:2890 2891 2892 2893] [KO:K05197 K05198 K05199 K05200] Tezampanel D06656 Tezampanel

  16. Drug: D07102 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available D07102 Drug Alizapride (INN); Plitican (TN) C16H21N5O2 315.1695 315.3702 D07102.gif... DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS A03F PROPULSIVES A03FA Propulsives A03FA05 Alizapride D07102 Alizapride...amily Dopamine dopamine D2-receptor [HSA:1813] [KO:K04145] Alizapride [ATC:A03FA05] D07102 Alizapride

  17. (Isopropyl­amino)(meth­yl)diphenyl­phospho­nium iodide

    Science.gov (United States)

    Peulecke, Normen; Peitz, Stephan; Müller, Bernd H.; Spannenberg, Anke; Rosenthal, Uwe

    2011-01-01

    The title compound, C16H21NP+·I−, was obtained by the reaction of Ph2PN(iPr)P(Ph)N(iPr)H with MeI involving cleavage of one of the P—N bonds in diethyl ether. The two phenyl rings form a dihedral angle of 82.98 (5)°. A weak donor–acceptor N—H⋯I inter­action is observed. PMID:21837129

  18. Dicty_cDB: Contig-U16289-1 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available LX4a46b02f1 250DPH (..) Rutilus rutilus cDNA cl... 84 1e-22 3 ( EG534235 ) RrLX4a46h21f1 250DPH (..) Rutilus...... 100 1e-22 3 ( BG260500 ) 602372044F1 NIH_MGC_93 Homo sapiens cDNA clone IM... 70 1e-22 4 ( EG534067 ) Rr

  19. EST Table: FS743730 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available FS743730 E_FL_bmmt_26H21_R_0 10/09/28 49 %/178 aa gb|ACN52067.1| insect intestinal mucin 3 [Mamestra configu...rata] 10/09/07 n.h 10/08/28 n.h 10/09/10 n.h 10/09/10 n.h 10/09/10 n.h FS740161 bmmt ...

  20. 30 aastat pärast diktatuuri hukku pole rahu Hispaaniasse naasnud / Priit Kivi

    Index Scriptorium Estoniae

    Kivi, Priit

    2005-01-01

    Ilmunud ka: Postimees : na russkom jazõke Ajal. Postimees : na russkom jazõke lüh. 21. nov., lk 11. Hispaania paremäärmuslased süüdistavad sotsialistlikku valitsust riigi tahtlikus lõhkumises. Franco-kummardajate terava vastuseisu on pälvinud valitsuse toetus samasooliste abielule, Kataloonia iseseisvuspüüdluste toetamine ning planeeritav õppekava, mis vähendab usuõpetuse tähtsust koolides. Lisa: Kindral Francisco Franco

  1. Drug: D07825 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available D07825 Drug Diethylcarbamazine (INN); Camin (TN) C10H21N3O 199.1685 199.2932 D07825...P02CB Piperazine and derivatives P02CB02 Diethylcarbamazine D07825 Diethylcarbamazine... (INN) Antiinfectives [BR:br08307] Antiparasitics Antinematodal agents Piperazine and derivatives Diethylcarbamazine... [ATC:P02CB02] D07825 Diethylcarbamazine (INN) CAS: 90-89-1 PubChem: 96024522 DrugBank: DB00711

  2. 1,5-Dimethyl-4-(1-methyl-3-oxo-3-phenylprop-1-enylamino-2-phenyl-1H-pyrazol-3(2H-one

    Directory of Open Access Journals (Sweden)

    Hualing Zhu

    2011-07-01

    Full Text Available In the title compound, C21H21N3O2, an intramolecular N—H...O interaction generates an S(6 ring, which stablizes the enamine–keto tautomer. The S(6 ring makes dihedral angles of 33.07 (7, 56.50 (8 and 38.59 (8°, respectively, with the benzoylacetone benzene ring and the antipyrine pyrazole and benzene rings.

  3. Occurrence and characterization of Shiga toxin-producing Escherichia coli O157:H7 and other non-sorbitol-fermenting E. coli in cattle and humans in urban areas of Morogoro, Tanzania

    DEFF Research Database (Denmark)

    Lupindu, Athumani M; Olsen, John Elmerdahl; Ngowi, Helena A

    2014-01-01

    effects on Vero cells. The prevalence of STEC in cattle was 1.6%, out of which 0.9% was serotype O157:H7 and the overall prevalence of diarrheagenic E. coli in cattle was 2.2%. The serotypes O157:H7, O142:H34, O113:H21, O+:H-, O+:H16, and O25:H4 were identified. One ESBL-producing isolate showed the MLST...

  4. 1-[Morpholino(phenylmethyl]-2-naphthol

    Directory of Open Access Journals (Sweden)

    Min Min Zhao

    2010-06-01

    Full Text Available There are two independent molecules in the asymmetric unit of the title compound, C21H21NO2, which was synthesized by the one-pot reaction of 2-naphthol, morpholine and benzaldehyde. The dihedral angles between the naphthalene ring systems and the benzene rings are 84.03 (7 and 75.76 (8° in the two molecules and an intramolecular O—H...N hydrogen bond occurs in each independent molecule.

  5. Stabilizing Effect of a Double-Harmonic RF System in the CERN PS

    CERN Document Server

    Bhat, C M; Damerau, H; Hancock, S; Mahner, E; Zimmermann, F

    2010-01-01

    Motivated by the discussions on scenarios for LHC upgrades, beam studies on the stability of flat bunches in a double-harmonic RF system have been conducted in the CERN Proton Synchrotron (PS). Injecting nearly nominal LHC beam intensity per cycle, 18 bunches are accelerated on harmonic h=21 to 26 GeV with the 10 MHz RF system. On the flat-top, all bunches are then transformed to flat bunches by adiabatically adding RF voltage at h=42 from a 20 MHz cavity in anti-phase to the h=21 system. The voltage ratio V(h42)/V(h21) of about 0.5 was set according to simulations. For the next 140 ms,longitudinal profiles show stable bunches in the double harmonic RF bucket until extraction. Without the second harmonic component, coupled-bunch oscillations are observed. The flatness of the bunches along the batch is analyzed as a measure of the relative phase error between the RF systems due to beam loading. Measurements of electron cloud effects induced by the beam are also discussed. The results of beam dynamics simulatio...

  6. Stabilizing effect of a double-harmonic RF system in the CERN PS

    CERN Document Server

    Bhat, C M; Damerau, H; Hancock, S; Mahner, E; Zimmermann, F

    2010-01-01

    Motivated by the discussions on scenarios for LHC upgrades, beam studies on the stability of flat bunches in a double-harmonic RF system have been conducted in the CERN Proton Synchrotron (PS). Injecting nearly nominal LHC beam intensity per cycle, 18 bunches are accelerated on harmonic h = 21 to 26GeV with the 10MHz RF system. On the flat-top, all bunches are then transformed to flat bunches by adiabatically adding RF voltage at h = 42 from a 20MHz cavity in anti-phase to the h = 21 system. The voltage ratio V (h42)/V (h21) of about 0.5 was set according to simulations. For the next 140 ms, longitudinal profiles show stable bunches in the double-harmonic RF bucket until extraction. Without the second harmonic component, coupled-bunch oscillations are observed. The flatness of the bunches along the batch is analyzed as a measure of the relative phase error between the RF systems due to beam loading. The results of beam dynamics simulations and their comparison with the measured data are presented.

  7. STABILIZING EFFECT OF A DOUBLE-HARMONIC RF SYSTEM IN THE CERN PS

    CERN Document Server

    Bhat, C M; Damerau, H; Hancock, S; Mahner, E; Zimmermann, F

    2009-01-01

    Motivated by the discussions on scenarios for LHC upgrades, beam studies on the stability of flat bunches in a double-harmonic RF system have been conducted in the CERN Proton Synchrotron (PS). Injecting nearly nominal LHC beam intensity per cycle, 18 bunches are accelerated on harmonic h = 21 to 26GeV with the 10MHz RF system. On the flat-top, all bunches are then transformed to flat bunches by adiabatically adding RF voltage at h = 42 from a 20MHz cavity in anti-phase to the h = 21 system. The voltage ratio V (h42)/V (h21) of about 0.5 was set according to simulations. For the next 140 ms, longitudinal profiles show stable bunches in the double-harmonic RF bucket until extraction. Without the second harmonic component, coupled-bunch oscillations are observed. The flatness of the bunches along the batch is analyzed as a measure of the relative phase error between the RF systems due to beam loading. The results of beamdynamics simulations and their comparison with the measured data are presented.

  8. Heat resistance of Fe-Al intermetallics in the context of selected heat-resistant and hihg-temperature creep resistant steels

    Directory of Open Access Journals (Sweden)

    P. Baranowski

    2009-04-01

    Full Text Available Results are hereby presented of heat-resistance tests of two Fe3Al and FeAl intermetallic phase-based alloys in the context of St41k-typeboiler steel and 50H21G9N4 high-temperature creep resistant steel. It has been ascertained that heat resistance of the 50H21G9N4 steeland of the Fe3Al and FeAl intermetallic phase-based alloys significantly exceeds that of the boiler steel tested in the air atmosphere and the atmosphere of a flue gas with CO, CO2, SiO2 content alike. Improvement of these properties depends of exposure conditions. The largest differences have been observed when the tests were carried out in temperature 1023 K and in the flue gas atmosphere. The differences have been more and more noticeable as the exposition duration extended. A tendency has been also recorded of smaller mass decrements of the Fe3Al and FeAl intermetallic phase-based alloys as compared to the 50H21G9N4 steel.

  9. 萘基桥联有机-无机杂化介孔材料的合成及其光学性质%Synthesis and Optical Properties of Organic-Inorganic Hybrid Mesoporous Materials with Naphthalene Bridging Groups

    Institute of Scientific and Technical Information of China (English)

    崔小燕; 韩书华; 孙元元; 王莎莎; 邱晓勇; 高萌

    2013-01-01

    Ordered naphthalene-bridged hybrid periodic mesoporous organosilicas (PMOs) were synthesized by co-condensation of 2,7-bis(3-triethoxysilylpropylaminocarbonyloxy) naphthalene (NIS) and tetraethoxy orthosilane (TEOS) using cationic trimeric surfactant [C10H21N +(CH3)2(CH2)2N +(CH3) (C10H21)-(CH2)2N+(CH3)2C10H21]·3Br- as a structure-directing agent. The resulting samples were characterized by powder X-ray diffraction, high resolution transmission electron microscopy, nitrogen adsorption-desorption, and differential scanning calorimetry/thermogravimetric analysis. Ordered mesoporous hybrid materials with a crystal-like pore wal formed when the molar ratio of NIS to the sum of NIS and TEOS was 40%. When this value is below or above 40%, ordered mesoporous hybrid materials with amorphous phase in the pore wal s, and nonporous hybrid materials are obtained, respectively. As the number of naphthyl groups in the pore wal s increases, the thermal stability of the hybrid materials is enhanced through the strongπ-πinteractions between organic groups. Because of the fluorescent naphthyl groups in the silica framework, the PMOs exhibit optical behavior consistent with excimer formation. Absorption spectra of the PMOs show blue shifts compared with that of the precursor (NIS), suggesting the formation of aggregates in the pore wal s of the hybrid materials. As the molar ratio of NIS to the sum of NIS and TEOS increases, the fluorescence quantum yield of the PMOs decreases through fluorescence quenching caused by aggregation of naphthyl groups.%  以短链阳离子三聚表面活性剂[C10H21N+(CH3)2(CH2)2N+(CH3)(C10H21)(CH2)2N+(CH3)2C10H21]·3Br-为结构导向剂,通过2,7-二(3-三乙氧硅基氨丙酯基)萘(NIS)和四乙氧基硅烷(TEOS)共缩聚,制备了有序的萘基桥联的杂化周期性介孔有机硅(PMOs)。样品通过X射线衍射(XRD)、高分辨透射电镜(HRTEM)、氮气吸附-脱附、差示扫描量热/热重分析(DSC/TGA)表征

  10. Drug: D02477 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available D02477 Drug Meclocycline sulfosalicylate (USP); Meclan (TN) C22H21ClN2O8. C7H6O6S 694.0872 695.0477 D0247...10AF Antiinfectives for treatment of acne D10AF04 Meclocycline D02477 Meclocyclin...f 30S ribosomal subunit inhibitor [KO:K01977] Tetracyclines Meclocycline [ATC:D10AF04] D02477 Meclocycline s...ulfosalicylate (USP) CAS: 73816-42-9 PubChem: 7849532 LigandBox: D02477 NIKKAJI:

  11. Drug: D00110 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available D00110 Drug Cocaine (USP); Cocaine (TN) C17H21NO4 303.1471 303.3529 D00110.gif Eryt...:K04841] hsa04726(6532) Serotonergic synapse hsa04728(6323+6531) Dopaminergic synapse hsa05030(6531) Cocaine... Sodium channel blocking drugs map07234 Neurotransmitter transporter inhibitors map05030 Cocaine addiction A... N01 ANESTHETICS N01B ANESTHETICS, LOCAL N01BC Esters of benzoic acid N01BC01 Cocaine D00110 Cocaine (USP) R... RESPIRATORY SYSTEM R02 THROAT PREPARATIONS R02A THROAT PREPARATIONS R02AD Anesthetics, local R02AD03 Cocaine D00110 Coca

  12. Drug: D03797 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available D03797 Drug Prinomastat (USAN/INN) C18H21N3O5S2 423.0923 423.5064 D03797.gif Antine...metalloproteinase 2 [HSA:4313] [KO:K01398] Prinomastat D03797 Prinomastat (USAN/INN) matrix metalloproteinas...e 3 [HSA:4314] [KO:K01394] Prinomastat D03797 Prinomastat (USAN/INN) matrix metal...loproteinase 9 [HSA:4318] [KO:K01403] Prinomastat D03797 Prinomastat (USAN/INN) matrix metalloproteinase 13 ...[HSA:4322] [KO:K07994] Prinomastat D03797 Prinomastat (USAN/INN) matrix metalloproteinase 14 [HSA:4323] [KO:K07763] Prinomas

  13. Supervivencia de VTEC O157 y no-O157 en agua de bebederos y materia fecal de bovinos

    OpenAIRE

    Rosana Polifroni; Etcheverría, Analía I.; Arroyo, Guillermo H; Padola, Nora L.

    2016-01-01

    Verotoxin-producing E. coli (VTEC) are the etiologic agent of hemolytic-uremic syndrome (HUS), that affect children typically ranged in age from six months old to five years old. The transmission is produced by consumption of contaminated foods, by direct contact with animals or the environment and person to person. In previous studies we determined that the environment of a dairy farm is a non animal reservoir, for that we proposed to study the survival of 4 VTEC isolates (O20:H19; O91:H21; ...

  14. 5-Cyclohexyl-3-(4-fluorophenylsulfinyl-2-methyl-1-benzofuran

    Directory of Open Access Journals (Sweden)

    Hong Dae Choi

    2011-04-01

    Full Text Available In the title compound, C21H21FO2S, the cyclohexyl ring adopts a chair conformation. The 4-fluorophenyl ring makes a dihedral angle of 83.55 (4° with the mean plane of the benzofuran fragment. In the crystal, molecules are linked through weak intermolecular C—H...O and C—H...π interactions. The crystal structure also exhibits aromatic π–π interactions between the furan rings of neighbouring molecules [centroid–centroid distance = 3.541 (2 Å].

  15. 5-Cyclohexyl-3-(4-fluorophenylsulfonyl-2-methyl-1-benzofuran

    Directory of Open Access Journals (Sweden)

    Hong Dae Choi

    2011-04-01

    Full Text Available In the title compound, C21H21FO3S, the cyclohexyl ring adopts a chair conformation. The 4-fluorophenyl ring makes a dihedral angle of 77.71 (4° with the mean plane of the benzofuran fragment. In the crystal, molecules are linked through intermolecular C—H...O hydrogen bonds and aromatic π–π interactions between the furan rings of neighbouring molecules [centroid–centroid distance = 3.578 (2 Å].

  16. Drug: D07473 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available D07473 Drug Atomoxetine (INN); Tomoxetine C17H21NO 255.1623 255.3547 D07473.gif Ant...TROPICS N06BA Centrally acting sympathomimetics N06BA09 Atomoxetine D07473 Atomoxetine (INN) USP drug classi...ty Disorder Agents, Non- amphetamines Atomoxetine D07473 Atomoxetine (INN) Target-based classification of dr...ugs [BR:br08310] Transporters Solute carrier family SLC6 SLC6A2 (noradrenalin transporter) [HSA:6530] [KO:K05035] Atom...oxetine [ATC:N06BA09] D07473 Atomoxetine (INN) CAS: 83015-26-3 PubChem:

  17. La misura della pressione fiscale in rapporto al prodotto interno lordo in luogo del prodotto interno netto:un capitolo dell'illusione fiscale

    Directory of Open Access Journals (Sweden)

    Francesco Forte

    2012-04-01

    Full Text Available The present paper calls attention on a major macroeconomic fiscal illusion: that arising fram the current official practice of expressing the main fiscal indicators and particularly tax burden as percentage of GDP rather than NDPF (Net Domestic Product at Factor Costs. This methodology causes a systematic undervaluation af the tax burden, by something between 25% (Sweden and Austria and 15% (Switzerland. Correctly measured, tax bur­den in most European countries is much abave 50% and in the Nordic coun­tries above 65% or close to it!  JEL Codes: H20, H21Keywords:

  18. Drug: D02100 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available D02100 Drug Ziprasidone mesylate (USAN); Ziprasidone mesylate hydrate; Geodon (TN) ...C21H21ClN4OS. CH4SO3. 3H2O 562.1323 563.0871 D02100.gif Antipsychotic [central D2 and 5HT2 receptor antagoni... N05 PSYCHOLEPTICS N05A ANTIPSYCHOTICS N05AE Indole derivatives N05AE04 Ziprasidone D02100 Ziprasidone mesyl...ate (USAN) USP drug classification [BR:br08302] Antipsychotics 2nd Generation/Atypical Ziprasidone D02100 Zi...prasidone mesylate (USAN) Bipolar Agents Bipolar Agents, Other Ziprasidone D02100

  19. Drug: D01004 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available D01004 Drug Homatropine hydrobromide (JP16/USP); Isopto homatropine (TN) C16H21NO3.... HBr 355.0783 356.2548 D01004.gif Anticholinergic [ophthalmic] Therapeutic category: 1311 ATC code: S01FA05 ...ing nervous system and sensory organs 13 Agents affecting sensory organs 131 Ophthalmic agents 1311 Mydriatic agents D0100... S01FA Anticholinergics S01FA05 Homatropine D01004 Homatropine hydrobromide (JP16/USP) Target-based classifi...nic cholinergic receptor [HSA:1128 1129 1131 1132 1133] [KO:K04129 K04130 K04131 K04132 K04133] Homatropine [ATC:S01FA05] D0100

  20. Crystal structure of 1-(2,4-dimethylphenyl-2-(4-trimethylsilyl-1H-1,2,3-triazol-1-ylethanone

    Directory of Open Access Journals (Sweden)

    G. B. Venkatesh

    2014-12-01

    Full Text Available The asymmetric unit of the title compound, C15H21N3OSi, contains two molecules with similar conformations (r.m.s. overlay fit for the 20 non-H atoms = 0.163 Å. The dihedral angles between the planes of the 1,2,3-triazole and 2,4-dimethylbenzene rings are 27.0 (3 and 19.5 (3°. In the crystal, molecules are linked by very weak C—H...O and C—H...N hydrogen bonds to generate [100] chains. The chains are cross-linked by C—H...π interactions.

  1. (R-[(R-3-Benzyl-2-oxooxazolidin-4-yl][4-(methylsulfonylphenyl]methyl acetate

    Directory of Open Access Journals (Sweden)

    Feng Li

    2014-05-01

    Full Text Available The structure of the title compound, C20H21NO6S, is of interest with respect to its antibacterial properties. The oxazolidine ring makes dihedral angles of 79.63 (14 and 56.16 (12° with the phenyl and benzene rings, respectively, while the phenyl and benzene rings make a dihedral angle of 64.37 (13°. In the crystal, non-classical C—H...O hydrogen bonds link adjacent molecules along the c axis.

  2. ALMA Observations of Orion Source I at 350 and 660 GHz

    CERN Document Server

    Plambeck, R L

    2016-01-01

    Orion Source I ('SrcI') is the protostar at the center of the Kleinmann-Low Nebula. ALMA observations of SrcI at 350 and 660 GHz failed to detect the H26$\\alpha$ and H21$\\alpha$ recombination lines, ruling out the possibility that SrcI is a hypercompact HII region. The deconvolved size of the continuum source is approximately 0.23 x 0.05" (100 x 20 AU); it is interpreted as a disk viewed almost edge-on. The continuum flux density is proportional to $\

  3. Acoustooptic Diffraction in Borate Crystals

    CERN Document Server

    Martynyuk-Lototska, I; Krupych, O; Adamiv, V; Smirnov, Ye; Vlokh, R

    2004-01-01

    The efficiency of acoustooptic (AO) diffraction in a-BaB2O4 and Li2B4O7 crystals is studied experimentally. The crystals are shown to be quite good AO materials. The efficiency of AO diffraction in a-BaB2O4 reaches h=30% at the electric signal power of P=0.7W for the transverse acoustic wave and 15% at the power of P=0.56W for the longitudinal wave. The same parameter for Li2B4O7 reaches h=21% at P=0,81W for the longitudinal acoustic wave.

  4. Diethyl [(4-nitrobenzamido(phenylmethyl]phosphonate

    Directory of Open Access Journals (Sweden)

    Jing-Wei Chen

    2014-05-01

    Full Text Available In the title compound, C18H21N2O6P, the dihedral angle between the benzene and phenyl rings is 85.1 (2°. In the crystal, molecules are linked via pairs of N—H...O(=P hydrogen bonds, forming inversion dimers with graph-set notation R22(10. One of the ethyl groups is disordered over two sets of sites, with occupancies 0.746 (11 and 0.254 (11.

  5. Crystal structure of diethyl [(4-nitrophenylamino(2-hydroxyphenylmethyl]phosphonate methanol monosolvate

    Directory of Open Access Journals (Sweden)

    QingMing Wang

    2014-09-01

    Full Text Available In the title compound, C17H21N2O6P·CH3OH, the planes of the 4-nitroaniline and 2-hydroxyphenyl groups form a dihedral angle of 84.04 (8°. The P atom exhibits tetrahedral geometry involving two O-ethyl groups, a Cα atom and a double-bonded O atom. In the crystal, O—H...O, N—H...O and C—H...O hydrogen bonds link the α-aminophosphonic acid and methanol molecules into chains that propagate parallel to the a axis.

  6. rac-Dimethyl 2-(tert-butylamino-5-oxo-4,5-dihydropyrano[3,2-c]chromene-3,4-dicarboxylate

    Directory of Open Access Journals (Sweden)

    S. Antony Inglebert

    2011-11-01

    Full Text Available The title compound, C20H21NO7, is asymmetric with a chiral centre located in the pyran ring and crystallizes as a racemate. The molecular framework is somewhat bent; the coumarin moiety and the pyran ring are inclined by 7.85 (5°. The molecular structure is characterized by an intramolecular N—H...O hydrogen bond, which generates an S(6 ring motif, and the crystal packing is stabilized by intermolecular C—H...O hydrogen bonds. The 3-carboxylate O atom is involved in both of them, having a bifurcated character.

  7. A Microcomputer-Based Method for Predicting Viscous Flow about a Ship Hull.

    Science.gov (United States)

    1982-12-01

    09100 CPRI =SORT(CNUFRS*UEI*Sll1*121*SIN(THETAI)*Hll/H21 09200 * *UREFI/UE1 09300 CPR’--SRT(CNUFRS*UE2- *Sl2)*H22*SIN(THETA2)*H12/H22 09400 * *UREFI/(JE...2 09500 CPR3=S(’,RT(CNUFRS*UE3*Sl3)*H23*SIN(THETA3)*H13/H23 09600 * *UREFI/UE3 09700 DCPDZ=Dl* CPRI +D2*CPR2.:"+D3*CPR3 09800 IF(NX.EG,.NXr) Go To: 120

  8. (S-Methyl 2-benzamido-3-(3,4-dimethoxyphenylpropanoate

    Directory of Open Access Journals (Sweden)

    Tricia Naicker

    2012-01-01

    Full Text Available The dimethoxypbenzene ring in the title compound, C19H21NO5, is gauche to the amide group and anti to the ester group. The chirality was confirmed to be S from two-dimensional NMR spectroscopy. In the crystal, N—H...O and C—H...O hydrogen bonds and several short-contact interactions (2.07–3.45 Å create chains parallel to [110]. The phenyl ring is disordered over two orientations in a 0.54 (2:0.46 (2 ratio.

  9. Tris(4-methylphenylphosphine selenide

    Directory of Open Access Journals (Sweden)

    Alfred Muller

    2011-01-01

    Full Text Available In the title molecule, C21H21PSe or PSe(C7H73, the P atom has a distorted PSeC3 tetrahedral environment, formed by the Se atom [P=Se = 2.1119 (5 Å] and three aryl rings. Two short intramolecular C—H...Se contacts occur. In the crystal, weak intermolecular C—H...Se interactions link the molecules into zigzag double chains propagating in [100]. The previous report of this structure [Zhdanov et al. (1953. Dokl. Akad. Nauk SSSR (Russ. (Proc. Nat. Acad. Sci. USSR, 92, 983–985] contained no geometrical data.

  10. Tris(4-methylphenyl)phosphine selenide

    OpenAIRE

    Alfred Muller

    2011-01-01

    In the title molecule, C21H21PSe or PSe(C7H7)3, the P atom has a distorted PSeC3 tetrahedral environment, formed by the Se atom [P=Se = 2.1119 (5) Å] and three aryl rings. Two short intramolecular C—H...Se contacts occur. In the crystal, weak intermolecular C—H...Se interactions link the molecules into zigzag double chains propagating in [100]. The previous report of this structure [Zhdanov et al. (1953). Dokl. Akad. Nauk SSSR (Russ.) (Proc. Na...

  11. Money or Joy

    DEFF Research Database (Denmark)

    Alstadsæter, Annette; Kolm, Anne-Sofie; Larsen, Birthe

    2005-01-01

    This paper examines the effect of taxes on the individuals' choices of educational direction, and thus on the economy.s skill composition. A proportional labour tax induces too many workers with high innate ability to choose an educational type associated with high consumption value and low effort....... This increases the skill mismatch and aggregate unemployment in the economy. The government can correct for this distortion by use of differentiated tuition fees or tax rates.JEL codes: J64, J68, H21, H24Keywords: Unemployment, matching, education, optimal taxation, tuition fees...

  12. (2E-3-{4-[(1H-1,3-Benzimidazol-2-ylmethoxy]-3-ethoxyphenyl}-1-(4-bromophenylprop-2-en-1-one monohydrate

    Directory of Open Access Journals (Sweden)

    Jerry P. Jasinski

    2011-04-01

    Full Text Available In the title compound, C25H21BrN2O3·H2O, the benzimidazole fragment and the water molecule of crystallization are each disordered over two sets of sites of equal occupancy. The dihedral angles between the least-squares planes of the benzimidazole and the 3-ethoxy- and 4-bromobenzene rings are 86.9 (6 and 85.1 (1°, respectively in one disorder component. The crystal packing is stabilized by intermolecular O—H...O, O—H...N and N—H...N hydrogen bonds, which link the molecules into chains along the a axis.

  13. N-(2-Allyl-4-ethoxy-2H-indazol-5-yl-4-methylbenzenesulfonamide

    Directory of Open Access Journals (Sweden)

    Hakima Chicha

    2014-05-01

    Full Text Available The indazole ring system of the title compound, C19H21N3O3S, is almost planar (r.m.s. deviation = 0.0192 Å and forms dihedral angles of 77.99 (15 and 83.9 (3° with the benzene ring and allyl group, respectively. In the crystal, centrosymmetrically related molecules are connected by pairs of N—H...O hydrogen bonds into dimers, which are further linked by C—H...O hydrogen bonds, forming columns parallel to the b axis.

  14. trans-Dichloridobis[tris(2-methoxyphenylphosphine]palladium(II

    Directory of Open Access Journals (Sweden)

    Charmaine van Blerk

    2009-11-01

    Full Text Available The structure of the title compound, [PdCl2(C21H21O3P2], shows a nearly square-planar geometry for the PdII atom within the Cl2Pd[P(PhOMe3]2 ligand set. The PdII atom sits on a centre of inversion and therefore the asymmetric unit contains one half-molecule, i.e. half of one PdII atom, one Cl atom and one tris(2-methoxyphenylphosphine ligand.

  15. Diazido{(S-1-phenyl-N,N-bis[(2-pyridylmethyl]ethanamine}copper(II

    Directory of Open Access Journals (Sweden)

    Sankara Rao Rowthu

    2011-07-01

    Full Text Available In the title compound, [Cu(N32(C20H21N3], the CuII ion is coordinated by the three N atoms of the (S-1-phenyl-N,N-bis[(2-pyridylmethyl]ethanamine ligand and two N atoms from two azide anions, resulting in a distorted square-pyramidal environment. A weak intermolecular C—H...N hydrogen-bonding interaction between one pyridine group of the ligand and an azide N atom of an adjacent complex unit gives a one-dimensional chain structure parallel to the c axis.

  16. Diphenyl[2-(2-pyridylaminomethylphenyl]phosphine oxide

    Directory of Open Access Journals (Sweden)

    Simón Hernández-Ortega

    2010-05-01

    Full Text Available The title compound, C24H21N2OP, was obtained by reacting 2-aminopyridine and 2-(diphenylphosphinylbenzaldehyde in ethanol. It crystallizes with two crystallographically independent molecules in the asymmetric unit. The aminopyridine units and the benzene ring bonded to the phosphine oxide P atom form dihedral angles of 88.58 (7 and 82.47 (9° in the two molecules. The crystal structure displays strong N—H...O and weak C—H...O hydrogen bonds along the b axis and C—H...π aromatic intra- and intermolecular interactions.

  17. Drug: D08421 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available D08421 Drug Procainamide (INN) C13H21N3O 235.1685 235.3253 D08421.gif Antiarrhythmic... Same as: C07401 ATC code: C01BA02 Class I antiarrhythmic agent voltage-gated sodium channel (SCN1A) blocke...581] Transporter inhibition: SLC47A1 [HSA:55244] map07037 Antiarrhythmic drugs map07213 Dopamine receptor ag... CLASS I AND III C01BA Antiarrhythmics, class Ia C01BA02 Procainamide D08421 Procainamide (INN) USP drug cla...ssification [BR:br08302] Cardiovascular Agents Antiarrhythmics Procainamide D08421 Procainamide (INN) Target

  18. Drug: D00483 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available 6H21NO2. HCl 295.1339 295.8044 D00483.gif Anti-adrenergic [beta-receptor]; Cardiac depressant [anti-arrhythmic...] Therapeutic category: 2123 2149 ATC code: C07AA05 Class II antiarrhythmic agent beta1-adrenergic recepto...enomic biomarker: CYP2D6 [HSA:1565] CYP inhibition: CYP1A2 [HSA:1544] map07037 Antiarrhythmic drugs map07048... Cardiovascular agents 212 Antiarrhythmic agents 2123 Beta blockers D00483 Propranolol hydrochloride (JP16/U

  19. Drug: D00477 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available Pronestyl (TN) C13H21N3O. HCl 271.1451 271.7863 D00477.gif Cardiac depressant [anti-arrhythmic] Therapeutic ...category: 2121 ATC code: C01BA02 Class I antiarrhythmic agent (Ia) voltage-gated sodium channel (SCN1A) bloc...:6581] Transporter inhibition: SLC47A1 [HSA:55244] map07028 Antipsychotics map07037 Antiarrhythmic drugs map...TIARRHYTHMICS, CLASS I AND III C01BA Antiarrhythmics, class Ia C01BA02 Procainami...de D00477 Procainamide hydrochloride (JP16/USP) USP drug classification [BR:br08302] Cardiovascular Agents Antiarrhythmic

  20. Aids to Navigation Service Force Mix 2000 Project. Volume 1. Development and Application of an Aids to Navigation Service Force Mix Decision Support System

    Science.gov (United States)

    1992-07-01

    Hours: 0.00 LT ANT ?: DBN ANT ?: (Database: Survey.db Report#: 6) Appendix H Page H-21 12/02/91 BUOY TENDER SUMMARY Page 22 Primary Unit: ACACIA District...2-5 2.2.4 ATON Tug Barges ........................ 2-5 2.2.5 Aids to Navigation Teams ( ANTs ) ................. 2-6 2.3 ATON SERVICES...navigation boat ANT aids to navigation team AOPS abstract of operations ATON aids to navigation ATONIS aids to navigation information system BRIDGE

  1. Drug: D01428 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available D01428 Drug Fenoterol hydrobromide (JAN); Berotec (TN) C17H21NO4. HBr 383.0732 384....ividual organs 22 Respiratory organ agents 225 Bronchodilators 2252 Isoprenalines D01428 Fenoterol hydrobromide...-adrenoreceptor agonists R03AC04 Fenoterol D01428 Fenoterol hydrobromide (JAN) R03C ADRENERGICS FOR SYSTEMIC... USE R03CC Selective beta-2-adrenoreceptor agonists R03CC04 Fenoterol D01428 Fenoterol hydrobromide...psin family Adrenaline beta2-adrenergic receptor [HSA:154] [KO:K04142] Fenoterol [ATC:G02CA03] D01428 Fenoterol hydrobromide

  2. Ethyl 2-(1,2,3,4-tetrahydrospiro[carbazole-3,2′-[1,3]dioxolan]-9-ylacetate

    Directory of Open Access Journals (Sweden)

    Philipp M. G. Löffler

    2009-04-01

    Full Text Available In the title compound, C18H21NO4, the hydrogenated six-membered ring of the carbazole unit adopts a half-chair conformation. The dioxolane ring and ethylacetate substituent point to opposite sides of the carbazole plane. The ethylacetate substituent adopts an essentially fully extended conformation, and its mean plane forms a dihedral angle of 83.8 (1° with respect to the carbazole mean plane. The molecules are arranged into stacks in which the carbazole planes form a dihedral angle of 4.4 (1° and have an approximate interplanar separation of 3.6 Å.

  3. [(4-Methylbenzylbis(pyridin-2-ylmethylamine-κ3N,N′,N′′]bis(thiocyanato-κScopper(II dichloromethane hemisolvate

    Directory of Open Access Journals (Sweden)

    Yan Qi

    2012-04-01

    Full Text Available The title compound, [Cu(NCS2(C20H21N3]·0.5CH2Cl2, crystallized with two independent complex molecules (A and B in the asymmetric unit, accompanied by one dichloromethane solvent molecule. Each CuII atom has a square-pyramidal geometry, being coordinated by five N atoms, three from the (4-methylbenzylbis(pyridin-2-ylmethylamine ligand and two from the thiocyanate ligands. In the crystal, the B molecules are linked via C—H...S interactions, forming chains propagating along [100].

  4. 3-{[Bis(pyridin-2-ylmethylamino]methyl}-2-hydroxy-5-methylbenzaldehyde

    Directory of Open Access Journals (Sweden)

    Ruo-Xu Wang

    2012-06-01

    Full Text Available In the title compound, C21H21N3O2, the pyridine rings and the benzene ring lie in a propeller arrangement around the central tertiary amine N atom. The dihedral angles formed by the benzene ring with the pyridine rings are 61.0 (3 and 49.6 (3°, while the dihedral angle between the pyridine rings is 69.7 (3°. The molecular conformation is stabilized by intramolecular bifurcated O—H...N hydrogen bonds. In the crystal, inversion dimers are formed via pairs of C—H...N hydrogen bonds.

  5. 5′-Methylsulfanyl-4′-oxo-7′-phenyl-3′,4′-dihydro-1′H-spiro[cyclohexane-1,2′-quinazoline]-8′-carbonitrile dimethylformamide monosolvate

    Directory of Open Access Journals (Sweden)

    Xuan Liu

    2011-08-01

    Full Text Available In the title compound, C21H21N3OS·C3H7NO, the carbonitrile molecule is built up of two fused six-membered rings and one six-membered ring linked through a spiro C atom. The 1,3-diaza ring adopts an envelope conformation and the cyclohexane ring adopts a chair conformation. The dihedral angle between the aromatic rings is 46.7 (3°. In the crystal, the components are linked by N—H...O hydrogen bonds.

  6. Drug: D02689 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available D02689 Drug Ramelteon (JAN/USAN/INN); Rozerem (TN) C16H21NO2 259.1572 259.3434 D026...sory organs 11 Agents affecting central nervous system 119 Miscellaneous 1190 Miscellaneous D02689 Ramelteon... N NERVOUS SYSTEM N05 PSYCHOLEPTICS N05C HYPNOTICS AND SEDATIVES N05CH Melatonin receptor agonists N05CH02 Ramelteon D02689 Ramelt...eon (JAN/USAN/INN) USP drug classification [BR:br08302] Sleep Disorder Agents Sleep Disorders, Other Ramelt...eon D02689 Ramelteon (JAN/USAN/INN) Target-based classificat

  7. Dicty_cDB: AFI627 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available 19D15 5' sequence, mRNA sequence. 38 0.12 2 AI490786 |AI490786.1 EST241494 tomato shoot, Cornell Lycopersico...e, mRNA sequence. 38 0.12 2 AI773934 |AI773934.1 EST255034 tomato resistant, Cornell Lycopersicon esculentum...11252.5 Drosophila melanogaster clone BACR23H21, complete sequence. 42 0.058 6 AI484136 |AI484136.1 EST248943 tomato resistant, Corne...ll Lycopersicon esculentum cDNA clone cLER1C5, mRNA sequence. 38 0.12 2 BG128254 |B

  8. 5′-Methyl-4′-oxo-7′-phenyl-3′,4′-dihydro-1′H-spiro[cyclohexane-1,2′-quinazoline]-8′-carbonitrile

    Directory of Open Access Journals (Sweden)

    Jianhong Tang

    2011-07-01

    Full Text Available The title compound, C21H21N3O, was obtained by cyclocondensation of 3-amino-5-methyl-[1,1′-biphenyl]-2,4-dicarbonitrile with cyclohexanone. The six-membered 1,3-diaza ring assumes an envelope conformation [with the flap atom displaced by 0.511 (7 Å from the plane through the other ring atoms] and the cyclohexane ring displays a chair conformation. The dihedral angle between the aromatic rings is 42.61 (7°.In the crystal, the molecules form hydrogen-bonded bands along [011].

  9. (E-N-[Cyclopentyl(morpholin-4-ylmethylidene]-4-fluorobenzenesulfonamide

    Directory of Open Access Journals (Sweden)

    Ilya Efimov

    2016-01-01

    Full Text Available The title compound, C16H21FN2O3S, was obtained from the reaction between sulfonyl azide, cyclohexanone and morpholine. The bond lengths at the amidine N—C—N grouping are similar [1.326 (3 and 1.338 (3 Å], indicating significant conjugation. The cyclopentyl moiety displays disorder of one of the methylene groups into two orientations with occupancy coefficients 0.75/0.25. No shortened intermolecular contacts in the crystal are observed.

  10. 5-(Anthracen-9-yl-3-(4-nitrophenyl-1-phenyl-4,5-dihydro-1H-pyrazole

    Directory of Open Access Journals (Sweden)

    Bao-Li Dong

    2010-11-01

    Full Text Available In the title compound, C29H21N3O2, the five-membered pyrazoline ring is nearly planar, the maximum deviation being 0.037 (3 Å. The anthracene ring system is approximately perpendicular to the central pyrazoline ring, making a dihedral angle of 86.55 (16°, whereas the two attached benzene rings are oriented at smaller dihedral angles of 12.9 (2 and 14.7 (2°with respect to the pyrazoline ring. An intramolecular C—H...N hydrogen bond is observed.

  11. Diethylenetriaminium hexafluoridotitanate(IV fluoride

    Directory of Open Access Journals (Sweden)

    J. Lhoste

    2008-11-01

    Full Text Available The title compound, (C6H21N4[TiF6]F, was synthesized by the reaction of TiO2, tris(2-aminoethylamine, HF and ethanol at 463 K in a microwave oven. The crystal structure consists of two crystallographically independent [TiF6]2− anions, two fluoride anions and two triply-protonated tris(2-aminoethylamine cations. The Ti atoms are coordinated by six F atoms within slightly distorted octahedra. The anions and cations are connected by intermolecular N—H...F hydrogen bonds.

  12. N-(2-Chlorophenyl-2-({5-[4-(methylsulfanylbenzyl]-4-phenyl-4H-1,2,4-triazol-3-yl}sulfanylacetamide

    Directory of Open Access Journals (Sweden)

    Hoong-Kun Fun

    2011-08-01

    Full Text Available In the title molecule, C24H21ClN4OS2, the central 1,2,4-triazole ring forms dihedral angles of 89.05 (9, 86.66 (9 and 82.70 (10° with the chloro-substituted benzene ring, the methylsulfanyl-substituted benzene ring and the phenyl ring, respectively. In the crystal, molecules are linked into sheets parallel to (100 by intermolecular N—H...N and weak C—H...O hydrogen bonds.

  13. turboTDDFT 2.0 - Hybrid functionals and new algorithms within time-dependent density-functional perturbation theory

    CERN Document Server

    Ge, Xiaochuan; Rocca, Dario; Gebauer, Ralph; Baroni, Stefano

    2014-01-01

    We present a new release of the turboTDDFT code featuring an implementation of hybrid functionals, a recently introduced pseudo-Hermitian variant of the Liouville-Lanczos approach to time-dependent density-functional perturbation theory, and a newly developed Davidson-like algorithm to compute selected interior eigenvalues/vectors of the Liouvillian super-operator. Our implementation is thoroughly validated against benchmark calculations performed on the cyanin (C$_{21}$O$_{11}$H$_{21}$) molecule using the Gaussian09 and turboTDDFT 1.0 codes.

  14. EST Table: FS730301 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available FS730301 E_FL_bmmt_18H21_F_0 10/09/28 96 %/137 aa ref|NP_731941.1| effete [Drosophi...la melanogaster] ref|NP_001119686.1| effete [Acyrthosiphon pisum] ref|XP_310998.2| AGAP000145-PA [Anopheles ...protein ligase) (Ubiquitin carrier protein) (Protein effete) [Tribolium castaneum...AltName: Full=Ubiquitin-protein ligase; AltName: Full=Ubiquitin carrier protein; AltName: Full=Protein effet...e emb|CAA44453.1| ubiquitin-conjugating enzyme [Drosophila melanogaster] gb|AAF55093.1| effet

  15. Drug: D00415 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available D00415 Drug Zolmitriptan (JAN/USAN/INN); Zomig (TN) C16H21N3O2 287.1634 287.3568 D0...asoconstrictors 2160 Vasoconstrictors D00415 Zolmitriptan (JAN/USAN/INN) Anatomic...PREPARATIONS N02CC Selective serotonin (5HT1) agonists N02CC03 Zolmitriptan D00415 Zolmitriptan (JAN/USAN/IN...d Receptor Agonists Zolmitriptan D00415 Zolmitriptan (JAN/USAN/INN) Target-based classification of drugs [BR...:br08310] G Protein-coupled receptors Rhodopsin family Serotonin 5-HT1B-receptor [HSA:3351] [KO:K04153] Zolmitriptan

  16. Drug: D00451 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available D00451 Drug Sumatriptan (JAN/USP/INN); Imigran (TN); Imitrex (TN) C14H21N3O2S 295.1...216 Vasoconstrictors 2160 Vasoconstrictors D00451 Sumatriptan (JAN/USP/INN) Anato...NE PREPARATIONS N02CC Selective serotonin (5HT1) agonists N02CC01 Sumatriptan D00451 Sumatriptan (JAN/USP/IN...d Receptor Agonists Sumatriptan D00451 Sumatriptan (JAN/USP/INN) Target-based classification of drugs [BR:br...08310] G Protein-coupled receptors Rhodopsin family Serotonin 5-HT1B-receptor [HSA:3351] [KO:K04153] Sumatriptan

  17. Drug: D02147 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available D02147 Drug Albuterol (USP); Salbutamol; Proventil (TN) C13H21NO3 239.1521 239.3107... D02147.gif Bronchodilator [DS:H00079] ATC code: R03AC02 R03CC02 beta2-adrenergic receptor agonist [HSA:154]...3A ADRENERGICS, INHALANTS R03AC Selective beta-2-adrenoreceptor agonists R03AC02 Salbutamol D02147 Albuterol... (USP); Salbutamol R03C ADRENERGICS FOR SYSTEMIC USE R03CC Selective beta-2-adren...oreceptor agonists R03CC02 Salbutamol D02147 Albuterol (USP); Salbutamol USP drug classification [BR:br08302

  18. Drug: D07563 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available D07563 Drug Alizapride hydrochloride; Plitican (TN) C16H21N5O2. HCl 351.1462 351.83...ETABOLISM A03 DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS A03F PROPULSIVES A03FA Propulsives A03FA05 Alizapride D07563 Alizapride...receptors Rhodopsin family Dopamine dopamine D2-receptor [HSA:1813] [KO:K04145] Alizapride... [ATC:A03FA05] D07563 Alizapride hydrochloride CAS: 59338-87-3 PubChem: 51091884 LigandBox: D07563

  19. 3-(4-Hexyloxyphenyl-1,2,4-triazolo[3,4-b]benzothiazole

    Directory of Open Access Journals (Sweden)

    Dieter Schollmeyer

    2014-03-01

    Full Text Available The title compound, C20H21N3OS, was prepared by Huisgen reaction of 5-(4-hexyloxyphenyltetrazole and chlorobenzothiazole. The essentially planar benzothiazolotriazole framework [maximum deviation from the mean plane of 0.077 (1 Å for the bridgehead N atom] and the phenyl ring form a dihedral angle of 53.34 (5°. The hexyloxy chain adopts a gauche–all-anti conformation. The intracentroid separation of 3.7258 (8 Å between the triazole and benzene rings is the closest contact between individual molecules in the crystal.

  20. (E-2-[4-(Piperidin-1-ylbenzylidene]-2,3-dihydro-1H-inden-1-one

    Directory of Open Access Journals (Sweden)

    Mohamed Ashraf Ali

    2010-11-01

    Full Text Available In the title compound, C21H21NO, the indene ring system is essentially planar with a maximum deviation of 0.066 (1 Å and makes dihedral angles of 7.93 (6 and 2.43 (6°, respectively, with the benzene plane and the mean plane of the piperidine ring. These latter two planes make a dihedral angle of 7.61 (7°. In the crystal, molecules are linked by C—H...O interactions, forming infinite chains along the b axis.

  1. Calculation of Electromagnetic Scattering by a Perfect Conductor.

    Science.gov (United States)

    1980-06-05

    AD-A091 027 NAVAL SURFACE WEAPONS CENTER SILVER SPRING NO0 F/G 20/3 CALCULATION OF ELECTROMAGNETIC SCATTERING BY A PERFECT CONDUCTO --ETCIU) JUN G0 A...let aO,r nonBr. We have 1E.2 - aHl.2 = V.(H I x E2) BE 1.E 2 _ * H H_ . 21. MUller , C., Foundations of the Mathematical Theory of Electromagnetic...20. Kellogg, R. B., "A Scattering Problem for Maxwell’s Equations," Ibid. 21. MUller , C., Foundations of the Mathematical Theory of Electromagnetic

  2. Dichlorido[N-(N,N-dimethylcarbamimidoyl-N′,N′,4-trimethylbenzohydrazonamide]platinum(II nitromethane hemisolvate

    Directory of Open Access Journals (Sweden)

    Dmitrii S. Bolotin

    2014-04-01

    Full Text Available In the title compound, [PtCl2(C13H21N5]·0.5CH3NO2, the PtII atom is coordinated in a slightly distorted square-planar geometry by two Cl atoms and two N atoms of the bidentate ligand. The (1,3,5-triazapentadienePtII metalla ring is slightly bent and does not conjugate with the aromatic ring. In the crystal, N—H...Cl hydrogen bonds link the complex molecules, forming chains along [001]. The nitromethane solvent molecule shows half-occupancy and is disordered over two sets of sites about an inversion centre.

  3. Drug: D00803 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available D00803 Drug Diethylcarbamazine citrate (JP16/USP); Hetrazan (TN) C10H21N3O. C6H8O7 ...642 Anthelmintics 6428 Piperazines D00803 Diethylcarbamazine citrate (JP16/USP) A...REPELLENTS P02 ANTHELMINTICS P02C ANTINEMATODAL AGENTS P02CB Piperazine and derivatives P02CB02 Diethylcarbamazine D00803 Diethylcarb...ntiparasitics Antinematodal agents Piperazine and derivatives Diethylcarbamazine [ATC:P02CB02] D00803 Diethylcarbamazine...amazine citrate (JP16/USP) Antiinfectives [BR:br08307] A

  4. Ethyl 2-(4-bromophenyl-1-[3-(1H-imidazol-1-ylpropyl]-1H-benzimidazole-5-carboxylate monohydrate

    Directory of Open Access Journals (Sweden)

    Yeong Keng Yoon

    2011-11-01

    Full Text Available In the title compound, C22H21BrN4O2·H2O, the two pyrazole rings are essentially planar [maximum deviations 0.002 (1 and 0.002 (1 Å], and form a dihedral angle of 73.46 (9°. The dihedral angle between the benzene rings is 29.33 (7°. In the crystal, molecules are connected via C—H...O and O—H...N hydrogen bonds, forming layers in the ab plane.

  5. 1-[(6-Chloro-3-pyridylmethyl]-N-(4-ethoxyphenyl-3-phenyl-1H-pyrazole-5-carboxamide

    Directory of Open Access Journals (Sweden)

    Zheng Tang

    2009-04-01

    Full Text Available In the title compound, C24H21ClN4O2, the pyrazole ring makes dihedral angles of 7.70 (11, 89.17 (11 and 40.68 (11° with the phenyl, pyridine and ethoxyphenyl rings, respectively. There are some intramolecular C—H...O and C—H...π bonds giving rigidity to the molecule, while weak intermolecular N—H...N and C—H...π hydrogen bonds link the molecules into a two-dimensional structure.

  6. Crystal structure of 5-[4-(di-methyl-amino)-phen-yl]-3-(4-methyl-phen-yl)-4,5-di-hydro-1H-pyrazole-1-carbaldehyde.

    Science.gov (United States)

    Adam, Farook; Samshuddin, Seranthimata; Ameram, Nadiah; Subramaya; Samartha, Laxminarayana

    2015-12-01

    The title compound, C19H21N3O, comprises a central pyrazole ring which is N-connected to an aldehyde group and C-connected twice to substituted benzene rings. The pyrazole ring is twisted on the C-C single bond, and the least-squares plane through this ring forms dihedral angles of 82.44 (5) and 4.52 (5)° with the (di-methyl-amino)-benzene and p-tolyl rings, respectively. In the crystal, weak C-H⋯O hydrogen bonds link mol-ecules into supra-molecular tubes along the b axis.

  7. Drug: D08100 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available D08100 Drug Ketobemidone (INN) C15H21NO2 247.1572 247.3327 D08100.gif Opioid Analge... NERVOUS SYSTEM N02 ANALGESICS N02A OPIOIDS N02AB Phenylpiperidine derivatives N02AB01 Ketobemidone D08100 K...04 2905 2906] [KO:K05208 K05209 K05210 K05211 K05212] Ketobemidone [ATC:N02AB01] D08100 Ketobemidone (INN) C...AS: 469-79-4 PubChem: 96024790 LigandBox: D08100 NIKKAJI: J5.929C ATOM 18 1 C1z C

  8. La riduzione dei tassi dell'interesse

    Directory of Open Access Journals (Sweden)

    P. SYLOS LABINI

    2013-10-01

    Full Text Available The article considers the effects of raising the tax rate on gross interest payments on public bonds in Italy. Several economists have suggested that such a measure is a duplication devoid of real effects because, given the demand for such bonds, the State would be forced to increase the gross interest payment by exactly the same amount it collects by raising the tax rate. By contrast, the author claims that such a measure would provide a net cash benefit for the public finances.  JEL Codes: E43, H21, H63Keywords: Tax rates, interest payments, Italy, public finances

  9. Drug: D01830 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available D01830 Drug Arotinolol hydrochloride (JP16); Almarl (TN) C15H21N3O2S3. HCl 407.0563... 408.0021 D01830.gif Antihypertensive Therapeutic category: 2123 alpha1-adrenergic receptor antagonist [HSA:...146 147 148] [KO:K04137 K04136 K04135]; beta1-adrenergic receptor antagonist [HSA:153] [KO:K04141]; beta2-adr...energic receptor antagonist [HSA:154] [KO:K04142]; beta3-adrenergic receptor ant...48+153+154+155) Neuroactive ligand-receptor interaction hsa04261(146+147+148+153+154) Adrenergic signaling i

  10. Drug: D07465 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available D07465 Drug Arotinolol (INN) C15H21N3O2S3 371.0796 371.5411 D07465.gif Antiarrhythmic alpha1-adr...energic receptor antagonist [HSA:146 147 148] [KO:K04137 K04136 K04135]; beta1-adrenergic recep...tor antagonist [HSA:153] [KO:K04141]; beta2-adrenergic receptor antagonist [HSA:154] [KO:K04142]; beta3-adre...61(146+147+148+153+154) Adrenergic signaling in cardiomyocytes hsa04270(146+147+148) Vascular smooth muscle ...contraction hsa04970(146+147+148+153+154+155) Salivary secretion map07214 beta-Adr

  11. Nutritional disorder of lettuce cv. Veronica in nutrient solution with suppressed macronutrients

    Directory of Open Access Journals (Sweden)

    Thiago Batista Firmato de Almeida

    2011-06-01

    Full Text Available Lettuce is the most popular of the leafy vegetables. It is known worldwide and its consumption occurs mainly in the natural form. The objective was to evaluate the effect of macronutrient omission on the growth and nutritional status of the lettuce cv. Veronica, and to describe the visual symptoms of nutritional deficiency. The treatments complete consisted of the solution and the individual omission of N, P, K, Ca, Mg and S, under a completely randomized design with three replications. Plants were grown in Hoagland & Arnon, in pots (8L. At 56 days after transplant we evaluated plant height, leaf number, leaf area, SPAD index, dry matter of shoots, roots and whole plant, levels of macronutrients in shoots and roots, and the nature of nutritional disorders. The omission of nutrients affected the growth variables. The nutrients found in lettuce plants from nutrient solution and the complete omission in the shoot were, respectively, N= 23.2 to 9.5, P= 5.4 to 1.3, K= 58,9 to 3.2, Ca= 12.1 to 3.6, Mg= 5.5 to 0.7 and S= 3.2 to 1.5g.kg-1. The omission of macronutrients caused quality losses, since it affected the nutrition of the vegetables and this resulted in morphological changes, reflected as symptoms of deficiency for each nutrient.

  12. Comparison of eight different agars for the recovery of clinically relevant non-O157 Shiga toxin-producing Escherichia coli from baby spinach, cilantro, alfalfa sprouts and raw milk.

    Science.gov (United States)

    Kase, Julie A; Maounounen-Laasri, Anna; Son, Insook; Lin, Andrew; Hammack, Thomas S

    2015-04-01

    The FDA Bacteriological Analytical Manual (BAM) Chapter 4a recommends several agars for isolating non-O157 Shiga toxin-producing Escherichia coli (STEC); not all have been thoroughly tested for recovering STECs from food. Using E. coli strains representing ten clinically relevant O serogroups (O26, O45, O91, O103, O104, O111, O113, O121, O128, O145) in artificially-contaminated fresh produce--bagged baby spinach, alfalfa sprouts, cilantro, and raw milk--we evaluated the performance of 8 different agars. Performance was highly dependent upon strain used and the presence of inhibitors, but not necessarily dependent on food matrix. Tellurite resistant-negative strains, O91:-, O103:H6, O104:H21, O113:H21, and O128, grew poorly on CHROMagar STEC, Rainbow agar O157, and a modified Rainbow O157 (mRB) agar. Although adding washed sheep's blood to CHROMagar STEC and mRB agars improved overall performance; however, this also reversed the inhibition of non-target bacteria provided by original formulations. Variable colony coloration made selecting colonies from Rainbow agar O157 and mRB agars difficult. Study results support a strategy using inclusive agars (e.g. L-EMB, SHIBAM) in combination with selective agars (R & F E. coli O157:H7, CHROMagar STEC) to allow for recovery of the most STECs while increasing the probability of recovering STEC in high bacterial count matrices. Published by Elsevier Ltd.

  13. Electrochemical Behavior and Determination of Trifluoperazine at Decanethiol Self- Assembled Monolayer Modified Gold Electrodes

    Institute of Scientific and Technical Information of China (English)

    HUANG Fei; YAN Quan-ping; ZENG Bai-zhao

    2005-01-01

    The electrochemical behavior of trifluoperazine at decanethiol self-assembled monolayer (SAM) modified gold electrodes (i. e. C10 H21 SH/Au) has been studied. Trifluoperazine can effectively accumulate on C10 H21 SH/Au elec trodes and generate a sensitive anodic peak at about 0. 63 V (vs. SCE) in 0.05 mol/L pH 9.4 Na2B4O7 buffer solution.Under the selected conditions, the anodic peak current was linear to trifluoperazine concentration in the range of 5.0 ×10 7-3. 0× 10-5 mol/L with correlation coefficient of 0. 997,the detection limit was 3.0 × 10-8 mol/L. This method was applied to the determination of trifluoperazine in drug samples and the recovery was 97.3%-104.0%. It was found that sodium dodecyl sulfate (SDS) could make the anodic peak current increase. In the presence of SDS, the peak at about 0.63V turned into two peaks, resulting from the change of the electrochemical mechanism.

  14. A Three-Generation Calabi-Yau Manifold with Small Hodge Numbers

    CERN Document Server

    Braun, Volker; Davies, Rhys

    2009-01-01

    We present a complete intersection Calabi-Yau manifold Y that has Euler number -72 and which admits free actions by two groups of automorphisms of order 12. These are the cyclic group Z_12 and the non-Abelian dicyclic group Dic_3. The quotient manifolds have chi=-6 and Hodge numbers (h^11,h^21)=(1,4). With the standard embedding of the spin connection in the gauge group, Y gives rise to an E_6 gauge theory with 3 chiral generations of particles. The gauge group may be broken further by means of the Hosotani mechanism combined with continuous deformation of the background gauge field. For the non-Abelian quotient we obtain a model with 3 generations with the gauge group broken to that of the standard model. Moreover there is a limit in which the quotients develop 3 conifold points. These singularities may be resolved simultaneously to give another manifold with (h^11,h^21)=(2,2) that lies right at the tip of the distribution of Calabi-Yau manifolds. This strongly suggests that there is a heterotic vacuum for t...

  15. Triadophilia: A Special Corner in the Landscape

    CERN Document Server

    Candelas, Philip; He, Yang-Hui; Szendroi, Balazs

    2007-01-01

    It is well known that there are a great many apparently consistent vacua of string theory. We draw attention to the fact that there appear to be very few Calabi--Yau manifolds with the Hodge numbers h^{11} and h^{21} both small. Of these, the case (h^{11}, h^{21})=(3,3) corresponds to a manifold on which a three generation heterotic model has recently been constructed. We point out also that there is a very close relation between this manifold and several familiar manifolds including the `three-generation' manifolds with \\chi=-6 that were found by Tian and Yau, and by Schimmrigk, during early investigations. It is an intriguing possibility that we may live in a naturally defined corner of the landscape. The location of these three generation models with respect to a corner of the landscape is so striking that we are led to consider the possibility of transitions between heterotic vacua. The possibility of these transitions, that we here refer to as transgressions, is an old idea that goes back to Witten. Here...

  16. The occurrence of subtilase-cytotoxin-encoding genes in environmental Escherichia coli isolated from a Northern California estuary.

    Science.gov (United States)

    Pereira, Maria das Graças C; Byrne, Barbara A; Nguyen, Trân B H; Lewis, David J; Atwill, E Robert

    2013-06-01

    The presence of subtilase-cytotoxin-encoding genes was determined in 397 environmental Escherichia coli strains isolated from water, suspended solids, and sediments sampled from different hydrological and environmental conditions in a California estuary. A total of 7 strains (1.76%) were found to harbor subtilase-cytotoxin-encoding genes. Using primers targeting subA only, we generated PCR amplicons from 2 strains; while using primers targeting the 3' end of SubA downstream to the 5' end of SubB, amplicons of 232 bp were generated from 5 additional strains. The 556 bp subA sequences were almost identical to that in the subtilase-cytotoxin-positive strain ED 591 (98%), while subAB sequences of 2 non-Shiga-toxigenic strains revealed 100% similarity with the Shiga-toxigenic E. coli O113:H21 strain 98NK2 that was isolated from an outbreak of hemolytic uremic syndrome. Additionally, the serogroup O113:H21 was present in this collection of environmental E. coli, and it was found to harbor stx2d, hra1 that encodes the heat resistant agglutinin 1, and a subAB sequence similar to that in the non-Shiga-toxigenic E. coli subtilase cytotoxin strain ED 591. To further understand potential health risks posed by strains encoding SubAB, future epidemiological studies should consider screening isolates for subAB regardless of the presence of Shiga-toxin-encoding genes.

  17. Size distribution of particle-phase molecular markers during a severe winter pollution episode.

    Science.gov (United States)

    Kleeman, Michael J; Riddle, Sarah G; Jakober, Chris A

    2008-09-01

    Airborne particulate matter was collected using filter samplers and cascade impactors in six size fractions below 1.8 microm during a severe winter air pollution event at three sites in the Central Valley of California. The smallest size fraction analyzed was 0.056 source apportionment calculations. Colocated impactor and filter measurements were highly correlated (R8 > 0.8) for retene, benzo[ghi]flouranthene, chrysene, benzo[b]fluoranthene, benzo[k]fluoranthene, benzo[e]pyrene, benzo[a]pyrene, perylene, indeno[1,2,3-cd]pyrene, benzo[ghi]perylene, coronene, MW302 polycyclic aromatic hydrocarbon (PAHs), 17beta(H)-21alpha(H)-30-norhopane, 17alpha(H)-21beta(H)-hopane, alphabetabeta-20R-C29-ethylcholestane, levoglucosan, and cholesterol. Of these compounds, levoglucosan was present in the highest concentration (60-2080 ng m(-3)) followed by cholesterol (6-35 ng m(-3)), PAHs (2-38 ng m(-3)), and hopanes and steranes (0-2 ng m(-3)). Nighttime concentrations were higher than daytime concentrations in all cases. Organic compound size distributions were generally similar to the total carbon size distributions during the nighttime but showed greater variability during the daytime. This may reflect the dominance of fresh emission in the stagnant surface layer during the evening hours and the presence of aged organic aerosol at the surface during the daytime when the atmosphere is better mixed. All of the measured organic compound particle size distributions had a single mode that peaked somewhere between 0.18 and 0.56 microm, but the width of each distribution varied by compound. Cholesterol generally had the broadest particle size distribution, while benzo[ghi]perylene and 17alpha(H)-21beta(H)-29-norhopane generally had sharper peaks. The difference between the size distributions of the various particle-phase organic compounds reflects the fact that these compounds exist in particles emitted from different sources. The results of the current study will prove useful for size

  18. 2010年福建南平及永安监测点致泻大肠杆菌的监测报告%Surveillance of diarrheagenic Escherichia coli infection in Nanping and Yongan monitoring sites of Fujian in 2010

    Institute of Scientific and Technical Information of China (English)

    林杰; 陈爱平; 陈建辉; 李玉燕; 杨劲松; 郑金凤

    2011-01-01

    目的:为了解福建省腹泻病人中致泻大肠杆菌的感染情况.方法:应用多重PCR或单重PCR方法检测致泻大肠杆菌的EPEC/EHEC eaeA基因、EHEC stx基因、EAEC aggR基因、EIECipaH、EIEC virA、ETEC ST、ETEC LT、EPECbp基因.API 20E生化鉴定条进行生化试验.血清学鉴定.结果:2010年度共分离得19株致泻大肠杆菌,检出率为10.9%.1株EAEC;1株tEPEC;4株aEPEC; 13株ETEC.19株分离的致泻大肠杆菌经API 20E鉴定均为大肠埃希菌.1株tEPEC与EPEC三种多价诊断血清型均不凝集,而1株aEPEC血清型为O111:K58(B4).13株ETEC菌株血清型:多数为O6:K15,1株O25:K19(L),3株未能分型.结论:监测结果对于我们了解福建省致泻大肠杆菌感染情况,预警潜在发生疫情的可能性有其重要性.这些菌种的获得可以为下一步研究其毒力特征、分子分型及耐药性积累原始材料.%Objective:To understand the condition of Diarrheagenic Escherichia coli (DEC) infection in Fujian province. Methods: Genes such as EPEC/EHEC eaek, EHEC stx, EAEC aggR, EIEC ipaH, EIEC virA, ETEC ST, ETEC LT, EPEC bfp were detected by multiplex or single PCR. Biochemical identification was determined by API 20E strip and serotyping was performed. Results: 19 strains of DEC (1 EAEC, 1 tEPEC, 4 aEPEC and 13 ETEC) were isolated in the surveillance in 2010, and the detection rate was 10.9%. All isolated strains were identified as E. Coli by API 20E strip. 1 tEPEC didn't agglutinate with EPEC multivalence diagnostic serum, whereas 1 aEPEC agglutinated with EPEC serum 0111 :K58( B4). Serotypes of 13 ETEC were mainly 06:K15, while the others were 1 strain for O25:K19(L) , 3 strains untyped. Conclusion: The surveillance is important to understand DEC infection in Fujian province and early warn the potential of DEC epidemic. The isolated strains provide material for further study of their virulence characteristics, molecular typing and antibiotic resistance.

  19. Molecular and Genetic Characterization of HIV-1 Tat Exon-1 Gene from Cameroon Shows Conserved Tat HLA-Binding Epitopes: Functional Implications

    Science.gov (United States)

    Teto, Georges; Fonsah, Julius Y.; Tagny, Claude T.; Mbanya, Dora; Nchindap, Emilienne; Kenmogne, Leopoldine; Fokam, Joseph; Njamnshi, Dora M.; Kouanfack, Charles; Njamnshi, Alfred K.; Kanmogne, Georgette D.

    2016-01-01

    HIV-1 Tat plays a critical role in viral transactivation. Subtype-B Tat has potential use as a therapeutic vaccine. However, viral genetic diversity and population genetics would significantly impact the efficacy of such a vaccine. Over 70% of the 37-million HIV-infected individuals are in sub-Saharan Africa (SSA) and harbor non-subtype-B HIV-1. Using specimens from 100 HIV-infected Cameroonians, we analyzed the sequences of HIV-1 Tat exon-1, its functional domains, post-translational modifications (PTMs), and human leukocyte antigens (HLA)-binding epitopes. Molecular phylogeny revealed a high genetic diversity with nine subtypes, CRF22_01A1/CRF01_AE, and negative selection in all subtypes. Amino acid mutations in Tat functional domains included N24K (44%), N29K (58%), and N40K (30%) in CRF02_AG, and N24K in all G subtypes. Motifs and phosphorylation analyses showed conserved amidation, N-myristoylation, casein kinase-2 (CK2), serine and threonine phosphorylation sites. Analysis of HLA allelic frequencies showed that epitopes for HLAs A*0205, B*5301, Cw*0401, Cw*0602, and Cw*0702 were conserved in 58%–100% of samples, with B*5301 epitopes having binding affinity scores > 100 in all subtypes. This is the first report of N-myristoylation, amidation, and CK2 sites in Tat; these PTMs and mutations could affect Tat function. HLA epitopes identified could be useful for designing Tat-based vaccines for highly diverse HIV-1 populations, as in SSA. PMID:27438849

  20. Budgeting of major nutrients and the mitigation options for nutrient mining in semi-arid tropical agro-ecosystem of Tamil Nadu, India using NUTMON model.

    Science.gov (United States)

    Surendran, U; Rama Subramoniam, S; Raja, P; Kumar, V; Murugappan, V

    2016-04-01

    Mining of nutrients from soil is a major problem in developing countries causing soil degradation and threaten long-term food production. The present study attempts to apply NUTrient MONitoring (NUTMON) model for carrying out nutrient budgeting to assess the stocks and flows of nitrogen (N), phosphorus (P), and potassium (K) in defined geographical unit based on the inputs, viz., mineral fertilizers, manures, atmospheric deposition, and sedimentation, and outputs, viz., harvested crop produces, residues, leaching, denitrification, and erosion losses. The study area covers Coimbatore and Erode Districts, which are potential agricultural areas in western agro-ecological zone of Tamil Nadu, India. The calculated nutrient balances for both the districts at district scale, using NUTMON methodology, were negative for nitrogen (N -3.3 and -10.1 kg ha(-1)) and potassium (K -58.6 and -9.8 kg ha(-1)) and positive for phosphorus (P +14.5 and 20.5 kg ha(-1)). Soil nutrient pool has to adjust the negative balance of N and K; there will be an expected mining of nutrient from the soil reserve. A strategy was attempted for deriving the fertilizer recommendation using Decision Support System for Integrated Fertilizer Recommendation (DSSIFER) to offset the mining in selected farms. The results showed that when DSSIFER recommended fertilizers are applied to crops, the nutrient balance was positive. NUTMON-Toolbox with DSSIFER would serve the purpose on enhancing soil fertility, productivity, and sustainability. The management options to mitigate nutrient mining with an integrated system approach are also discussed.

  1. A shock tube and theoretical study on the pyrolysis of 1,4-dioxane.

    Science.gov (United States)

    Yang, X; Jasper, A W; Giri, B R; Kiefer, J H; Tranter, R S

    2011-03-07

    The dissociation of 1, 2 and 4% 1,4-dioxane dilute in krypton was studied in a shock tube using laser schlieren densitometry, LS, for 1550-2100 K with 56 ± 4 and 123 ± 3 Torr. Products were identified by time-of-flight mass spectrometry, TOF-MS. 1,4-dioxane was found to initially dissociate via C-O bond fission followed by nearly equal contributions from pathways involving 2,6 H-atom transfers to either the O or C atom at the scission site. The 'linear' species thus formed (ethylene glycol vinyl ether and 2-ethoxyacetaldehyde) then dissociate by central fission at rates too fast to resolve. The radicals produced in this fission break down further to generate H, CH(3) and OH, driving a chain decomposition and subsequent exothermic recombination. High-level ab initio calculations were used to develop a potential energy surface for the dissociation. These results were incorporated into an 83 reaction mechanism used to simulate the LS profiles with excellent agreement. Simulations of the TOF-MS experiments were also performed with good agreement for consumption of 1,4-dioxane. Rate coefficients for the overall initial dissociation yielded k(123Torr) = (1.58 ± 0.50) × 10(59) × T(-13.63) × exp(-43970/T) s(-1) and k(58Torr) = (3.16 ± 1.10) × 10(79) × T(-19.13) × exp(-51326/T) s(-1) for 1600 < T < 2100 K.

  2. Molten salt CO2 capture and electro-transformation (MSCC-ET) into capacitive carbon at medium temperature: effect of the electrolyte composition.

    Science.gov (United States)

    Deng, Bowen; Chen, Zhigang; Gao, Muxing; Song, Yuqiao; Zheng, Kaiyuan; Tang, Juanjuan; Xiao, Wei; Mao, Xuhui; Wang, Dihua

    2016-08-15

    Electrochemical transformation of CO2 into functional materials or fuels (i.e., carbon, CO) in high temperature molten salts has been demonstrated as a promising way of carbon capture, utilisation and storage (CCUS) in recent years. In a view of continuous operation, the electrolysis process should match very well with the CO2 absorption kinetics. At the same time, in consideration of the energy efficiency, a molten salt electrochemical cell running at lower temperature is more beneficial to a process powered by the fluctuating renewable electricity from solar/wind farms. Ternary carbonates (Li : Na : K = 43.5 : 31.5 : 25.0) and binary chlorides (Li : K = 58.5 : 41.5), two typical kinds of eutectic melt with low melting points and a wide electrochemical potential window, could be the ideal supporting electrolyte for the molten salt CO2 capture and electro-transformation (MSCC-ET) process. In this work, the CO2 absorption behaviour in Li2O/CaO containing carbonates and chlorides were investigated on a home-made gas absorption testing system. The electrode processes as well as the morphology and properties of carbon obtained in different salts are compared to each other. It was found that the composition of molten salts significantly affects the absorption of CO2, electrode processes and performance of the product. Furthermore, the relationship between the absorption and electro-transformation kinetics are discussed based on the findings.

  3. Development of The Viking Speech Scale to classify the speech of children with cerebral palsy.

    Science.gov (United States)

    Pennington, Lindsay; Virella, Daniel; Mjøen, Tone; da Graça Andrada, Maria; Murray, Janice; Colver, Allan; Himmelmann, Kate; Rackauskaite, Gija; Greitane, Andra; Prasauskiene, Audrone; Andersen, Guro; de la Cruz, Javier

    2013-10-01

    Surveillance registers monitor the prevalence of cerebral palsy and the severity of resulting impairments across time and place. The motor disorders of cerebral palsy can affect children's speech production and limit their intelligibility. We describe the development of a scale to classify children's speech performance for use in cerebral palsy surveillance registers, and its reliability across raters and across time. Speech and language therapists, other healthcare professionals and parents classified the speech of 139 children with cerebral palsy (85 boys, 54 girls; mean age 6.03 years, SD 1.09) from observation and previous knowledge of the children. Another group of health professionals rated children's speech from information in their medical notes. With the exception of parents, raters reclassified children's speech at least four weeks after their initial classification. Raters were asked to rate how easy the scale was to use and how well the scale described the child's speech production using Likert scales. Inter-rater reliability was moderate to substantial (k>.58 for all comparisons). Test-retest reliability was substantial to almost perfect for all groups (k>.68). Over 74% of raters found the scale easy or very easy to use; 66% of parents and over 70% of health care professionals judged the scale to describe children's speech well or very well. We conclude that the Viking Speech Scale is a reliable tool to describe the speech performance of children with cerebral palsy, which can be applied through direct observation of children or through case note review. Copyright © 2013 Elsevier Ltd. All rights reserved.

  4. Position for Site-Specific Attachment of a DOTA Chelator to Synthetic Affibody Molecules Has a Different Influence on the Targeting Properties of 68Ga-Compared to 111In-Labeled Conjugates

    Directory of Open Access Journals (Sweden)

    Hadis Honarvar

    2014-12-01

    Full Text Available Affibody molecules, small (7 kDa scaffold proteins, are a promising class of probes for radionuclide molecular imaging. Radiolabeling of Affibody molecules with the positron-emitting nuclide 68Ga would permit the use of positron emission tomography (PET, providing better resolution, sensitivity, and quantification accuracy than single-photon emission computed tomography (SPECT. The synthetic anti-HER2 ZHER2:S1 Affibody molecule was conjugated with DOTA at the N-terminus, in the middle of helix 3, or at the C-terminus. The biodistribution of 68Ga- and 111In-labeled Affibody molecules was directly compared in NMRI nu/nu mice bearing SKOV3 xenografts. The position of the chelator strongly influenced the biodistribution of the tracers, and the influence was more pronounced for 68Ga-labeled Affibody molecules than for the 111In-labeled counterparts. The best 68Ga-labeled variant was 68Ga-[DOTA-A1]-ZHER2:S1 which provided a tumor uptake of 13 ± 1 %ID/g and a tumor to blood ratio of 39 ± 12 at 2 hours after injection. 111In-[DOTA-A1]-ZHER2:S1 and 111In-[DOTA-K58]-ZHER2:S1 were equally good at this time point, providing a tumor uptake of 15 to 16 %ID/g and a tumor to blood ratio in the range of 60 to 80. In conclusion, the selection of the best position for a chelator in Affibody molecules can be used for optimization of their imaging properties. This may be important for the development of Affibody-based and other protein-based imaging probes.

  5. Structure-Triggered High Quantum Yield Luminescence and Switchable Dielectric Properties in Manganese(II) Based Hybrid Compounds.

    Science.gov (United States)

    Wang, Zhong-Xia; Li, Peng-Fei; Liao, Wei-Qiang; Tang, Yuanyuan; Ye, Heng-Yun; Zhang, Yi

    2016-04-01

    Two new manganese(II) based organic-inorganic hybrid compounds, C11H21Cl3MnN2 (1) and C11H22Cl4MnN2 (2), with prominent photoluminescence and dielectric properties were synthesized by solvent modulation. Compound 1 with novel trigonal bipyramidal geometry exhibits bright red luminescence with a lifetime of 2.47 ms and high quantum yield of 35.8 %. Compound 2 with tetrahedral geometry displays intense long-lived (1.54 ms) green light emission with higher quantum yield of 92.3 %, accompanied by reversible solid-state phase transition at 170 K and a distinct switchable dielectric property. The better performance of 2 results from the structure, including a discrete organic cation moiety and inorganic metal anion framework, which gives the cations large freedom of motion.

  6. Crystal structure of (1,3-di-tert-butyl-η5-cyclopentadienyltrimethylhafnium(IV

    Directory of Open Access Journals (Sweden)

    Adrián Pérez-Redondo

    2015-05-01

    Full Text Available The molecule of the title organometallic hafnium(IV compound, [Hf(CH33(C13H21] or [HfMe3(η5-C5H3-1,3-tBu2], adopts the classical three-legged piano-stool geometry for monocyclopentadienylhafnium(IV derivatives with the three methyl groups bonded to the Hf(IV atom at the legs. The C atoms of the two tert-butyl group bonded to the cyclopentadienyl (Cp ring are 0.132 (5 and 0.154 (6 Å above the Cp least-squares plane. There are no significant intermolecular interactions present between the molecules in the crystal structure.

  7. Novel methanol-tolerant Ir-S/C chalcogenide electrocatalysts for oxygen reduction in DMFC fuel cell

    Institute of Scientific and Technical Information of China (English)

    Jingyu Ma; Desheng Ai; Xiaofeng Xie; Jianwei Guo

    2011-01-01

    Novel methanol-tolerant oxygen-reduction catalysts, iridium-sulphur (Ir-S) chalcogenides with differ ent Ir/S atomic ratios, were synthesized via a precipitation method using H21rCI6 and Na2SO3 as the Ir and S precursors. Powder X-ray diffraction (XRD) and transmission electron microscopy (TEM) were used to characterize the IrxSl-x/C chalcogenide catalysts. Particle size ranging from 2.5 to 2.8 nm though obvious agglomeration was found on carbon support. However, these chalcogenide catalysts showed strong catalytic activity towards the oxygen reduction reaction (ORR) and high methanol tolerance, strongly suggesting these novel catalysts as promising candidates for direct methanol fuel cell (DMFC) cathode applications.

  8. 6-Benzyl-3,4-dimethoxy-10-methylpyrido[2′,1′:2,3]imidazo[4,5-c]isoquinolin-5(6H-one

    Directory of Open Access Journals (Sweden)

    Kathrin Meindl

    2009-10-01

    Full Text Available Pyrido[2′,1′:2,3]imidazo[4,5-c]isoquinolin-5(6H-ones such as the title compound, C24H21N3O3, can be obtained in a few minutes in a microwave-assisted three-component reaction from 2-aminopyridines, isocyanides and 2-carboxybenzaldehydes. In the title compound, the pyrido[2′,1′:2,3]imidazo[4,5-c]isoquinolin-5(6H-one ring system is almost planar (mean deviation 0.068 Å. The dihedral angle between the benzyl ring and the pyrido[2′,1′:2,3]imidazo[4,5-c]isoquinolin-5(6H-one ring system is 78.2°. The crystal structure is stabilized by intermolecular C—H...O and C—H...N hydrogen bonds.

  9. DECENTRALIZATION, FISCAL CAPABILITY AND PUBLIC SPENDING EFFICIENCY

    Directory of Open Access Journals (Sweden)

    Abdul Hakim

    2012-01-01

    Full Text Available Assigning autonomy to regency governments in Indonesia has failed to increase regency’s economies.While it increases regency government role in planning and initiating policies, its impact oneconomic development has been insignificant. This stems from the lack of institution’s capacity inorganizing the bulk funds transfer from the central government which leads to inefficiency in resourceallocation. This paper maps these regencies based on their fiscal dependency. This paperalso applies Data Envelopment Analysis to identify the efficient and non efficient regencies in sucha way that the non efficient regencies might use the efficient ones as the benchmark to increase theirefficiency.Keywords: Autonomy, regency government, efficiencyJEL classification numbers: H21, H53, H71, H72

  10. Synthesis and Crystal Structure of 2-(N-Cyclohexyl)-imino-1,4-succinic Acid Dihydrate

    Institute of Scientific and Technical Information of China (English)

    郭金波; 李森兰; 郁兆莲; 陈庆华

    2005-01-01

    The title compound, 2-(N-cyclohexyl)-imino-1,4-succinic acid dihydrate 4, has been prepared and structurally determined by X-ray diffraction analysis. Crystal data: monoclinic, space group Cc, a = 7.5790(15), b = 24.860(5), c = 7.1394(14)(A), β = 104.23(3)°, V = 1303.9(4) (A)3, C10H21NO6, Mr = 251.28, Z = 4, Dc = 1.280 g/cm3, μ = 0.105 mm-1, F(000) = 544, R = 0.0397 and wR = 0.0918 for 1212 observed reflections with I ≥ 2σ(I). X-ray structure analysis reveals that there exist two intramolecular and six intermolecular hydrogen-bonding interactions in the crystal lattice, which can stabilize the configuration of the α-imino acid dihydrate 4.

  11. Theoretical Investigation on the Adsorption of Ag+ and Hydrated Ag+ Cations on Clean Si(111)Surface

    Institute of Scientific and Technical Information of China (English)

    SHENG Yong-Li; LI Meng-Hua; WANG Zhi-Guo; LIU Yong-Jun

    2008-01-01

    In this paper,the adsorption of Ag+ and hydrated Ag+ cations on clean Si(111)surface were investigated by using cluster(Gaussian 03)and periodic(DMol3)ab initio calculations.Si(111)surface was described with cluster models(Si14H17 and Si22H21)and a four-silicon layer slab with periodic boundary conditions.The effect of basis set superposition error(BSSE)was taken into account by applying the counterpoise correction.The calculated results indicated that the binding energies between hydrated Ag+ cations and clean Si(111)surface are large,suggesting a strong interaction between hydrated Ag+ cations and the semiconductor surface.With the increase of number,water molecules form hydrogen bond network with one another and only one water molecule binds directly to the Ag+ cation.The Ag+ cation in aqueous solution will safely attach to the clean Si(111)surface.

  12. A new layered iron fluorophosphate

    Indian Academy of Sciences (India)

    Amitava Choudhury

    2002-04-01

    A new iron fluorophosphate of the composition, [C6N4H21] [Fe2F2(HPO4)3][H2PO4]·2H2O, I has been prepared by the hydrothermal route. This compound contains iron fluorophosphate layers and the H2PO$_{4}^{-}$ anions are present in the interlayer space along with the protonated amine and water molecules. The compound crystallizes in the monoclinic space group 21/. ( = 13.4422(10) Å, = 9.7320(10) Å, = 18.3123(3) Å, = 92.1480 °, = 2393.92(5) Å3, = 4, = 719.92, calc = 1.997 g cm-3, 1 = 0.03 and 2 = 0.09).

  13. A novel high-performance high-frequency SOI MESFET by the damped electric field

    Science.gov (United States)

    Orouji, Ali A.; Khayatian, Ahmad; Keshavarzi, Parviz

    2016-06-01

    In this paper, we introduce a novel silicon-on-insulator (SOI) metal-semiconductor field-effect-transistor (MESFET) using the damped electric field (DEF). The proposed structure is geometrically symmetric and compatible with common SOI CMOS fabrication processes. It has two additional oxide regions under the side gates in order to improve DC and RF characteristics of the DEF structure due to changes in the electrical potential, the electrical field distributions, and rearrangement of the charge carriers. Improvement of device performance is investigated by two-dimensional and two-carrier simulation of fundamental parameters such as breakdown voltage (VBR), drain current (ID), output power density (Pmax), transconductance (gm), gate-drain and gate-source capacitances, cut-off frequency (fT), unilateral power gain (U), current gain (h21), maximum available gain (MAG), and minimum noise figure (Fmin). The results show that proposed structure operates with higher performances in comparison with the similar conventional SOI structure.

  14. Sõda on poliitika jätkamine teiste vahenditega : kuidas Euroopa ja USA on jõudnud Iraagi sõja õhtule / Toomas Hendrik Ilves

    Index Scriptorium Estoniae

    Ilves, Toomas Hendrik, 1953-

    2003-01-01

    Järg Eesti Päevaleht : Eriväljaanne 20. märts lk. 3 (lüh.) ; 21. märts lk. 3 "Maailmakord pärast Iraagi sõda" (täistekst) ;15. aprill lk. 3 "Tavalised vahendid pärast sõda". Autor selgitab, millised sajandite kogemused on viinud Euroopa ja USA tüli ning Iraagi sõjani. Iraagi sõja mõjust maailma uuele julgeolekusüsteemile.USA visioon sõjajärgsest Iraagist ja Lähis-Idast. USA võidu mõju Lähis-Ida rahvastele ja riikidele, Venemaale. Arvete klaarimine minevikuga kui Iraagi demokratiseerimise võtmeküsimus. Kommenteerivad Henry Kissinger ja Francis Fukuyama

  15. Synthesis and structural study of 4-(2-chlorophenyl)-2-ethoxy-5,6,7,8,9,10-hexahydrocycloocta[B]pyridine-3-carbonitrile

    Science.gov (United States)

    Fathima, K. Saiadali; Vasumathi, M.; Anitha, K.

    2016-05-01

    The novel organic material C20H21ClN2O was synthesized by One-Pot synthesis method and the single crystals were grown by slow evaporation solution growth technique. The crystal structure was elucidated by subjecting the grown crystals to the single crystal x-ray diffraction analysis and was refined by full matrix least-squares method to R=0.039 for 2746 reflections. Crystal system of the grown crystal was found to be monoclinic with the space group P21/a and a=9.196(4) Å, b=13.449(4) Å, c=14.818(4) Å, β= 101.542(3)°, V=1795.6(11) Å3 and Z=4. In this crystal structure, cyclooctanone prefers to reside in a chair-boat conformation. The structure is stabilized by attractive molecular force such as CH/π interaction called hydrophobic interaction.

  16. Tris(4-methyl­phen­yl)phosphine selenide

    Science.gov (United States)

    Muller, Alfred

    2011-01-01

    In the title mol­ecule, C21H21PSe or PSe(C7H7)3, the P atom has a distorted PSeC3 tetra­hedral environment, formed by the Se atom [P=Se = 2.1119 (5) Å] and three aryl rings. Two short intra­molecular C—H⋯Se contacts occur. In the crystal, weak inter­molecular C—H⋯Se inter­actions link the mol­ecules into zigzag double chains propagating in [100]. The previous report of this structure [Zhdanov et al. (1953 ▶). Dokl. Akad. Nauk SSSR (Russ.) (Proc. Nat. Acad. Sci. USSR), 92, 983–985] contained no geometrical data. PMID:21522754

  17. Tris(4-methyl-phen-yl)phosphine selenide.

    Science.gov (United States)

    Muller, Alfred

    2010-12-08

    In the title mol-ecule, C(21)H(21)PSe or PSe(C(7)H(7))(3), the P atom has a distorted PSeC(3) tetra-hedral environment, formed by the Se atom [P=Se = 2.1119 (5) Å] and three aryl rings. Two short intra-molecular C-H⋯Se contacts occur. In the crystal, weak inter-molecular C-H⋯Se inter-actions link the mol-ecules into zigzag double chains propagating in [100]. The previous report of this structure [Zhdanov et al. (1953 ▶). Dokl. Akad. Nauk SSSR (Russ.) (Proc. Nat. Acad. Sci. USSR), 92, 983-985] contained no geometrical data.

  18. (4S-4-Benzyl-N-{[(4S-4-benzyl-2-oxo-1,3-oxazolidin-3-yl]sulfonyl}-2-oxo-1,3-oxazolidine-3-carboxamide

    Directory of Open Access Journals (Sweden)

    Malika Berredjem

    2010-07-01

    Full Text Available The title compound, C21H21N3O7S, contains an oxazolidinone ring and a sulfonamide group, both characteristic for biologically and pharrmaceutically active compounds. Both stereogenic centres reveal an S absolute configuration. The two oxazolidinone rings are in an envelope conformation with the methylene carbon flap atoms deviating by 0.428 (1 and 0.364 (2 Å from the best least-square planes formed by the four other ring atoms. An intramolecular N—H...O hydrogen bond contributes to the folded conformation of the molecule. In the crystal, weak intermolecular C—H...O interactions connect the molecules into helices along the the twofold screw axes.

  19. Improved Bunch Splitting for the 75ns LHC Beam

    CERN Document Server

    Damerau, H

    2011-01-01

    The 75ns variant was added to the PS arsenal of LHC-type beams by adapting the 20MHz cavity used to produce the 25 and 50ns variants to operate at a switchable 13MHz. This permitted splitting from harmonic 14 to 28, but at a cost in adiabaticity compared with the h=2142 splitting of the other two cases. Consequently, a delicate empirical optimization was necessary to bring the 75ns beam inside specification. More recently the speed at which the bunches, once fully distinct, are moved apart has been revisited and further optimization achieved. As a by-product, deliberately degrading the splitting by moving the bunches apart too quickly led to sufficient coherent motion in the resultant bunch pair to permit a voltage calibration of the 13MHz cavity by means of the influence on convergence of the rf voltage input into the iterative algorithm of the Tomoscope [1,2].

  20. Crystal structure of (1,3-di-tert-butyl-η5-cyclo­penta­dien­yl)tri­methyl­hafnium(IV)

    Science.gov (United States)

    Pérez-Redondo, Adrián; Varela-Izquierdo, Víctor; Yélamos, Carlos

    2015-01-01

    The mol­ecule of the title organometallic hafnium(IV) com­pound, [Hf(CH3)3(C13H21)] or [HfMe3(η5-C5H3-1,3-tBu2)], adopts the classical three-legged piano-stool geometry for mono­cyclo­penta­dienylhafnium(IV) derivatives with the three methyl groups bonded to the Hf(IV) atom at the legs. The C atoms of the two tert-butyl group bonded to the cyclo­penta­dienyl (Cp) ring are 0.132 (5) and 0.154 (6) Å above the Cp least-squares plane. There are no significant inter­molecular inter­actions present between the mol­ecules in the crystal structure. PMID:25995884

  1. Crystal structure of (1,3-di-tert-butyl-η(5)-cyclo-penta-dien-yl)tri-methyl-hafnium(IV).

    Science.gov (United States)

    Pérez-Redondo, Adrián; Varela-Izquierdo, Víctor; Yélamos, Carlos

    2015-05-01

    The mol-ecule of the title organometallic hafnium(IV) com-pound, [Hf(CH3)3(C13H21)] or [HfMe3(η(5)-C5H3-1,3- (t) Bu2)], adopts the classical three-legged piano-stool geometry for mono-cyclo-penta-dienylhafnium(IV) derivatives with the three methyl groups bonded to the Hf(IV) atom at the legs. The C atoms of the two tert-butyl group bonded to the cyclo-penta-dienyl (Cp) ring are 0.132 (5) and 0.154 (6) Å above the Cp least-squares plane. There are no significant inter-molecular inter-actions present between the mol-ecules in the crystal structure.

  2. Sõda on poliitika jätkamine teiste vahenditega : kuidas Euroopa ja USA on jõudnud Iraagi sõja õhtule / Toomas Hendrik Ilves

    Index Scriptorium Estoniae

    Ilves, Toomas Hendrik, 1953-

    2003-01-01

    Järg Eesti Päevaleht : Eriväljaanne 20. märts lk. 3 (lüh.) ; 21. märts lk. 3 "Maailmakord pärast Iraagi sõda" (täistekst) ;15. aprill lk. 3 "Tavalised vahendid pärast sõda". Autor selgitab, millised sajandite kogemused on viinud Euroopa ja USA tüli ning Iraagi sõjani. Iraagi sõja mõjust maailma uuele julgeolekusüsteemile.USA visioon sõjajärgsest Iraagist ja Lähis-Idast. USA võidu mõju Lähis-Ida rahvastele ja riikidele, Venemaale. Arvete klaarimine minevikuga kui Iraagi demokratiseerimise võtmeküsimus. Kommenteerivad Henry Kissinger ja Francis Fukuyama

  3. Crystal structure of 1-[2-(4-chlorophenyl-4,5-diphenyl-1H-imidazol-1-yl]propan-2-ol

    Directory of Open Access Journals (Sweden)

    Shaaban K. Mohamed

    2017-01-01

    Full Text Available The title compound, C24H21ClN2O, crystallizes with two unique molecules in the asymmetric unit. In each molecule, the central imidazole ring is substituted at the 2-, 4- and 5-positions by benzene rings. The 2-substituted ring carries a Cl atom at the 4-position. One of the imidazole N atoms in each molecule has a propan-2-ol substituent. In the crystal, a series of O—H...N, C—H...O and C—H...Cl hydrogen bonds, augmented by several C—H...π(ring interactions, generate a three-dimensional network of molecules stacked along the a-axis direction.

  4. (4Z-2-Phenyl-1-{(E-[4-(propan-2-ylbenzylidene]amino}-4-[(thiophen-2-ylmethylidene]-1H-imidazol-5(4H-one

    Directory of Open Access Journals (Sweden)

    Kamni

    2016-04-01

    Full Text Available In the title molecule, C24H21N3OS, the imidazole ring subtends dihedral angles of 4.6 (1 and 20.2 (1° with the thiophene and iso-propylbenzene rings, respectively. The plane of the imidazole ring forms a dihedral angle of 39.9 (1° with the phenyl ring. An intramolecular C—H...N hydrogen bond closes an S(6 ring. In the crystal, pairs of C—H...O hydrogen bonds link molecules into inversion dimers featuring R22(10 graph-set motifs. Aromatic π–π stacking interactions are observed between the thiophene and imidazole rings [centroid–centroid distance = 3.570 (2 Å] and thiophene and benzene rings [centroid–centroid distance = 3.889 (2 Å]. Weak C—H...π interactions are also observed.

  5. Ethyl 1-[3-(1H-imidazol-1-ylpropyl]-2-(4-chlorophenyl-1H-benzo[d]imidazole-5-carboxylate dihydrate

    Directory of Open Access Journals (Sweden)

    Yeong Keng Yoon

    2011-09-01

    Full Text Available In the title compound, C22H21ClN4O2·2H2O, the almost-planar benzimidazole ring system [maximum deviation 0.014 (1 Å] is inclined at angles of 36.32 (5 and 74.75 (7° with respect to the phenyl and imidazole rings, respectively. In the crystal structure, the water molecules are linked to the organic molecules to form a three-dimensional network via O—H...N and O—H...O hydrogen bonds. The packing is further consolidated by a pair of bifurcated C—H...O bonds, generating R12(6 loops. C—H...π interactions are also observed.

  6. Bis(2-amino-5-benzyl-3-ethoxycarbonyl-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-5-ium bis(4-methoxyphenyldiphosphonate

    Directory of Open Access Journals (Sweden)

    Mehmet Akkurt

    2014-03-01

    Full Text Available The asymmetric unit of the title salt, 2C17H21N2O2S+·C14H14O7P22−, contains half of a centrosymmetric bis(4-methoxyphenyldiphosphonate anion and one 2-amino-5-benzyl-3-ethoxycarbonyl-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-5-ium cation. In the anion, the O atoms of the diphosphonate group are disordered over two positions with equal occupancies. In the cation, the ethyl group is disordered over two orientations with a refined occupancy ratio of 0.753 (5:0.247 (5, and the tetrahydropyridinium ring adopts a distorted half-chair conformation. In the crystal, the ions are linked by C—H...O, N—H...O and C—H...S hydrogen bonds into a three-dimensional network.

  7. Tribenzylammonium chloride

    Directory of Open Access Journals (Sweden)

    Waly Diallo

    2014-05-01

    Full Text Available Single crystals of the title salt, C21H21NH+·Cl−, were isolated as a side product from the reaction involving [(C6H5CH23NH]2[HPO4] and Sn(CH33Cl in ethanol. Both the cation and the anion are situated on a threefold rotation axis. The central N atom in the cation has a slightly distorted tetrahedral environment, with angles ranging from 107.7 to 111.16 (10°. In the crystal, the tribenzylammonium cations and chloride anions are linked through N—H...Cl and C—H...Cl hydrogen bonds, leading to the formation of infinite chains along [001]. The crystal studied was a merohedral twin.

  8. trans-Carbonylchloridobis(tri-p-tolylphosphinerhodium(I acetone solvate

    Directory of Open Access Journals (Sweden)

    Brian R. James

    2008-03-01

    Full Text Available The title compound, [RhCl(C21H21P2(CO]·C3H6O, was precipitated in trace yield from a reaction of RhCl(cod(THP with P(p-tol3 in a 1:1 acetone-d6/CD3OD solution under a hydrogen atmosphere [p-tol = p-tolyl, THP = tris(hydroxymethylphosphine, P(CH2OH3, and cod = 1,5-cyclooctadiene]. The complex displays a square-planar geometry around the RhI atom. The complex molecules and the acetone molecules are linked into a chain along the a axis by intermolecular C—H...Cl and C—H...O hydrogen bonds.

  9. Bis[μ-N-(tert-butyldimethylsilyl-N-(pyridin-2-ylmethylamido]bis[methylcobalt(II

    Directory of Open Access Journals (Sweden)

    Astrid Malassa

    2012-09-01

    Full Text Available The green title complex, [Co2(CH32(C12H21N2Si2], was obtained from bis{[μ-N-tert-butyldimethylsilyl-N-(pyridin-2-ylmethylamido]chloridocobalt(II} and methyllithium in diethyl ether at 195 K via a metathesis reaction. The dimeric cobalt(II complex exhibits a crystallographic center of inversion in the middle of the Co2N2 ring (average Co—N = 2.050 Å. The CoII atom shows a distorted tetrahedral coordination sphere. The exocyclic Co—N bond length to the pyridyl group shows a similar value of 2.045 (4 Å. The exocyclic methyl group has a rather long Co—C bond length of 2.019 (5 Å.

  10. 4-Phenyl-1-[(1R,4R-1,7,7-trimethyl-2-oxobicyclo[2.2.1]heptan-3-ylidene]hydrazinecarbothioamide

    Directory of Open Access Journals (Sweden)

    Gabriela Porto de Oliveira

    2016-11-01

    Full Text Available In the title compound, C17H21N3OS [common nomenclature: (R-camphor 4-phenylthiosemicarbazone], the N—N—C—(S—N fragment deviates slightly from planarity, with a maximum deviation of 0.0259 (12 Å for the hydrazinic N atom, and makes an angle of 29.55 (0° with the aromatic ring. The molecular structure is stabilized by an intramolecular N—H...O hydrogen bond and a short N—H...N interaction with graph-set motifs S(6 and S(5, respectively. In the crystal, the centrosymmetric arrangement of the molecules resembles a herringbone packing motif along [001]. As a result of the steric effects of the camphor entity, an apolar organic periphery and the intramolecular nature of the hydrogen bonds, neither strong nor relevant intermolecular interactions are observed.

  11. (E-4-[(1-Benzyl-4-benzylidene-2,5-dioxopyrrolidin-3-ylmethyl]benzaldehyde 0.25-hydrate

    Directory of Open Access Journals (Sweden)

    Tao Yu

    2012-04-01

    Full Text Available The crystal structure of the title compound, C26H21NO3·0.25H2O, reveals one stereogenic centre in the molecule. Nevertheless, due to the observed centrosymmetric space group, both enantiomers are present in the crystal packing. The water molecule of crystallisation is located on a crystallographic inversion center. The molecule contains one five-membered ring (A and three six-membered rings (benzyl ring B, benzylidene ring C and formylbenzyl ring D. All four rings are not coplanar: the dihedral angles between rings A and B, A and C, and A and D are 70.35 (9, 33.8 (1 and 60.30 (9°, respectively. In the crystal, pairs of weak C—H...O interactions lead to the formation of centrosymmetric dimers. Additional C—H...O interactions link the dimers into chains along [011].

  12. ESO 113-IG45 galaxy and/or quasar?

    CERN Document Server

    West, R M; Danks, A C

    1978-01-01

    Spectroscopy, UBV photometry and photography have been obtained of the extraordinary 13th magnitude object ESO 113-IG45 identified as a Seyfert galaxy by Fairall (1977); R.A.=01/sup h/ 21/sup m/.9; Decl .=-59 degrees 04' (1950). V/sub 0/=13630+or-50 km s/sup -1/; M/sub V /=-24/sup m/.0; largest diameter 75 kpc or more (with H/sub 0/=55 km s /sup -1/ Mpc/sup -1/). The nucleus is stellar-like and several times more luminous than the surrounding envelope which has a well-developed lane-structure. It is the intrinsically most luminous Seyfert nuclear yet known, and may be described as a 'quasar in the center of a (spiral) galaxy'. It is probably associated with the X-ray source 2A0120-591. (14 refs).

  13. Ethyl 2-(1,2,3,4-tetrahydro­spiro­[carba­zole-3,2′-[1,3]dioxolan]-9-yl)acetate

    Science.gov (United States)

    Löffler, Philipp M. G.; Ulven, Trond; Bond, Andrew D.

    2009-01-01

    In the title compound, C18H21NO4, the hydrogenated six-membered ring of the carbazole unit adopts a half-chair conformation. The dioxolane ring and ethyl­acetate substituent point to opposite sides of the carbazole plane. The ethyl­acetate substituent adopts an essentially fully extended conformation, and its mean plane forms a dihedral angle of 83.8 (1)° with respect to the carbazole mean plane. The mol­ecules are arranged into stacks in which the carbazole planes form a dihedral angle of 4.4 (1)° and have an approximate inter­planar separation of 3.6 Å. PMID:21582427

  14. N-(3-{[(Z-(3-Hydroxy-4-methylphenylimino]methyl}pyridin-2-ylpivalamide

    Directory of Open Access Journals (Sweden)

    Şehriman Atalay

    2016-03-01

    Full Text Available The molecular structure of the title compound, C18H21N3O2, contains pivalamide, pyridin and hydroxy-methylphenyl moieties. The whole molecule is not planar, the dihedral angle between the benzene rings being 34.84 (7°. The molecular conformation is stabilized by an intramolecular N—H...N hydrogen bond. In the crystal, molecules are linked by O—H...O, O—H...N and C—H...O hydrogen bonds. The C and H atoms of the tert-butyl group disordered over two sets of sites with an occupancy ratio of 0.692 (5:0.308 (5.

  15. Bis[(2-methylbenzylbis(pyridin-2-ylmethyl-κNamine-κN]manganese(II bis(perchlorate

    Directory of Open Access Journals (Sweden)

    Ray J. Butcher

    2014-03-01

    Full Text Available In the title complex, [Mn(C20H21N32](ClO42, two tridentate (2-methylbenzylbis(pyridin-2-ylmethylamine (L ligands form the MnII complex [MnL2](ClO42. The MnII ion lies on a twofold axis and the complex cation is significantly distorted from regular octahedral geometry. The packing is stabilized by weak C—H...O interactions between the cations and anions, which link them into a zigzag ribbon along [101]. The perchlorate anion is disordered and was constrained to be tetrahedral with two orientations having occupancies of 0.768 (4 and 0.232 (4. The 2-methylbenzyl moiety is also disordered over two sets of sites, with occupancies of 0.508 (15 and 0.492 (15.

  16. 5-Cyclohexyl-2-(2-fluorophenyl-3-methylsulfinyl-1-benzofuran

    Directory of Open Access Journals (Sweden)

    Hong Dae Choi

    2013-06-01

    Full Text Available In the title compound, C21H21FO2S, the cyclohexyl ring adopts a chair conformation. The 2-fluorobenzene ring makes a dihedral angle of 38.68 (6° with the mean plane [r.m.s. deviation = 0.018 (2 Å] of the benzofuran fragment. In the crystal, molecules are linked by pairs of C—H...O hydrogen bonds into dimers, which are further packed into stacks along the c axis by C—H...O hydrogen bonds. In addition, the stacked molecules exhibit S...O contacts [3.1733 (13 Å] involving the sulfinyl groups. The F atom is disordered over two positions, with site-occupancy factors of 0.961 (3 and 0.039 (3.

  17. A triclinic polymorph of (-)-(S)-N-benzyl-2-[(R)-6-fluoro-chroman-2-yl]-2-hy-droxy-ethanaminium bromide.

    Science.gov (United States)

    Rousselin, Yoann; Laureano, Hugo; Clavel, Alexandre

    2013-12-01

    The title salt, C18H21FNO2 (+)·Br(-), determined at 115 K, crystallizes in the triclinic space group P1. The previously reported polymorph occurs in the monoclinic space group P21 and has two independent mol-ecules in the asymmetric unit [Peeters et al. (1993 ▶). Acta Cryst. C49, 2157-2160]. In the title molecule, the pyran rings adopt half-chair conformations. The absolute configuration is S for the hy-droxy-bearing C atom and R for the asymmetric C atom in the di-hydro-pyran unit. In the crystal, the components are linked by N-H⋯Br and O-H⋯Br hydrogen bonds, forming chains along the c-axis direction. The crystal studied was refined as an inversion twin.

  18. 1-Decyl-6-nitro-1H-benzimidazol-2(3H-one

    Directory of Open Access Journals (Sweden)

    Younes Ouzidan

    2011-11-01

    Full Text Available The title molecule, C17H25N3O3, is built up from fused six- and five-membered rings linked to a –C10H21 chain. The fused-ring system is essentially planar, the largest deviation from the mean plane being 0.009 (2 Å. The chain is roughly perpendicular to this plane, making a dihedral angle of 79.5 (2°. In the crystal, N—H...O hydrogen bonds build infinite chains along [010]. There are channels in the structure containing disordered hexane. The contribution of this solvent to the scattering power was suppressed using the SQUEEZE option in PLATON [Spek (2009. Acta Cryst. D65, 148–155].

  19. Crystal growth and characterization studies of novel luminescent 2D coordination polymer of lead-benzilate possessing edge sharing PbO6 polyhedra

    Science.gov (United States)

    Soumya Mol, U. S.; Drisya, R.; Satheesh Chandran, P. R.; Sudarsanakumar, M. R.; Suma, S.; Sudhadevi Antharjanam, P. K.

    2016-12-01

    Single crystals of a new coordination polymer of lead-benzilate, C28H21O6Pb·C2H5OH have been successfully grown by gel diffusion technique at room temperature. The colourless single crystals were obtained within a week. The crystal structure was elucidated using single crystal X-ray diffraction studies. The compound possesses a polymeric structure constructed from edge sharing PbO6 polyhedra. Single crystal X-ray diffraction analysis showed that the compound crystallizes in triclinic space group P-1. The grown crystals were further characterized by elemental analysis, FT-IR, UV-Visible and thermogravimetric analysis. The photoluminescent properties of the complex and the ligand were also investigated.

  20. dc and microwave performance of a 0.1-micron gate InAs/In(0.52)Al(0.48)As MODFET

    Science.gov (United States)

    Yang, D.; Chen, Y. C.; Brock, T.; Bhattacharya, Pallab K.

    1992-06-01

    The performance characteristics of 0.1-micron gate InAs/In(0.52)Al(0.48)As MODFETs grown by molecular beam epitaxy are measured and analyzed. The transistors are characterized by measured g sub m (max) = 840 mS/mm, f sub T = 128 GHz, and a very high current carrying capability, e.g., I sub dss = 934 mA/mm at V sub gs = 0.4 V and V sub ds = 2.7 V. The value of f sub T is estimated from extrapolation of the current gain (H21) at a -6-dB/octave rolloff. This is the first report on the microwave characteristics of an InAs-channel MODFET and establishes the superiority of this heterostructure system.

  1. Must losing taxes on saving be harmful?

    DEFF Research Database (Denmark)

    Huizinga, Harry; Nielsen, Søren Bo

    2004-01-01

    are financed by taxes on savingand investment. There is international cross-ownership of firms, and countries areassumed to be unable to tax away pure profits. Countries then face an incentiveto impose a rather high investment tax also borne by foreigners. In this setting,the loss of the saving tax instrument...... on account of international tax evasion mayprevent the overall saving-investment tax wedge from becoming too high, and hencemay be beneficial for moderate preferences for public goods. A world with 'high-spending' governments, in contrast, is made worse off by the loss of saving taxes,and hence stands...... to gain from international cooperation to restore saving taxation.JEL-Classifcation: H87, H21Keywords: Capital income taxation, cross-ownership, coordination...

  2. Tetrahydroberberine, a pharmacologically active naturally occurring alkaloid.

    Science.gov (United States)

    Pingali, Subramanya; Donahue, James P; Payton-Stewart, Florastina

    2015-04-01

    Tetrahydroberberine (systematic name: 9,10-dimethoxy-5,8,13,13a-tetrahydro-6H-benzo[g][1,3]benzodioxolo[5,6-a]quinolizine), C20H21NO4, a widely distributed naturally occurring alkaloid, has been crystallized as a racemic mixture about an inversion center. A bent conformation of the molecule is observed, with an angle of 24.72 (5)° between the arene rings at the two ends of the reduced quinolizinium core. The intermolecular hydrogen bonds that play an apparent role in crystal packing are 1,3-benzodioxole -CH2···OCH3 and -OCH3···OCH3 interactions between neighboring molecules.

  3. Tris(4-methoxyphenylphosphine selenide

    Directory of Open Access Journals (Sweden)

    Melina Raymundo

    2016-08-01

    Full Text Available The title compound, C21H21O3PSe, is comprised of a P atom in a distorted tetrahedral environment, attached to the Se atom and three C atoms of the phenyl rings. The P—Se bond length is 2.1214 (12 Å. All three methoxy groups are near coplanar with their respective phenyl rings, with the angles between the phenyl ring and the C—O bond of the methoxy groups being 5.7 (2, 1.5 (4, and 5.7 (3°. The torsion angles of the phenyl rings relative to the P=Se bond are 35.62 (10, 35.07 (13, and 44.50 (11°. No strong intermolecular interactions were observed, but that in addition to van der Waals forces, there are C—H...π and C—H...Se close contacts.

  4. Control of nitrous oxide emission from Chironomus plumosus larvae by nitrate and temperatur

    DEFF Research Database (Denmark)

    Stief, Peter; Polerecky, Lubos; Poulsen, Morten

    2010-01-01

    of Chironomus plumosus in field and laboratory experiments. Larvae collected from lake sediments emitted between 2 and 73 pmol N2O ind.-1 h-1 during the warm season, but took up maximally 227 pmol N2O ind.21 h21 during winter. Larvae kept in laboratory microcosms emitted between 14 and 122 pmol N2O ind.-1 h-1......, and N2O uptake was never observed. For both types of larvae, the rate of N2O emission was stimulated by temperature (when the NO3- concentration in the water column was higher than 25–50 µmol L-1) and by NO3- (when the temperature was higher than 4–10°C). Modeling based on experimentally determined...

  5. 6-Butyl-5-(4-methylphenoxy-3-phenyl-3H-1,2,3-triazolo[4,5-d]pyrimidin-7(6H-one

    Directory of Open Access Journals (Sweden)

    Hong-Mei Wang

    2010-11-01

    Full Text Available In the title compound, C21H21N5O2, the triazolopyrimidine ring system is essentially planar [maximum displacement = 0.021 (4 Å] and forms dihedral angles of 41.17 (9 and 67.99 (8° with the phenyl and benzene rings, respectively. The n-butyl side chains is disordered over two positions with an ccupancy ratio of 0.77:0.23. An intramolecular C—H...O hydrogen-bonding interaction stabilizes the molecular conformation. In the crystal, molecules are linked by intermolecular C—H...O and C—H...N hydrogen bonds into a three-dimensional network. In addition, π–π stacking interactions involving the triazole and pyrimidine rings of adjacent molecules are observed, with centroid–centroid distances of 3.545 (1 Å.

  6. Crystal structure of ethyl 2-(2,4,5-trimethoxyphenylquinoline-4-carboxylate

    Directory of Open Access Journals (Sweden)

    T. O. Shrungesh Kumar

    2015-07-01

    Full Text Available In the title compound, C21H21NO5, the dihedral angle between the quinoline ring system (r.m.s. deviation = 0.028 Å and the trimethoxybenzene ring is 43.38 (5°. The C atoms of the methoxy groups deviate from their attached benzene ring by −0.396 (2, −0.049 (2 and 0.192 (2 Å for the ortho-, meta- and para-substituents, respectively. The pendant ethyl chain is disordered over two orientations in a 0.527 (5:0.473 (5 ratio. A short intramolecular C—H...O contact closes an S(6 ring. In the crystal, inversion dimers linked by pairs of weak C—H...O interactions generate R22(6 loops. The dimers are linked by further C—H...O interactions to generate [1-10] chains.

  7. Measuring Tax Efficiency

    DEFF Research Database (Denmark)

    Raimondos-Møller, Pascalis; Woodland, Alan D.

    2004-01-01

    This paper introduces an index of tax optimality thatmeasures the distance of some current tax structure from the optimal taxstructure in the presence of public goods. In doing so, we derive a [0, 1]number that reveals immediately how far the current tax configurationis from the optimal one and......, thereby, the degree of efficiency of a taxsystem. We call this number the Tax Optimality Index. We show howthe basic method can be altered in order to derive a revenue equivalentuniform tax, which measures the size of the public sector. A numericalexample is used to illustrate the method developed.......JEL Code: H21, H41.Keywords: Tax optimality index, excess burden, distance function.Authors Affiliations: Raimondos-Møller: Copenhagen Business School, CEPR,CESifo, and EPRU. Woodland: University of Sydney....

  8. Petroleum hydrocarbon persistence following the Deepwater Horizon oil spill as a function of shoreline energy.

    Science.gov (United States)

    Evans, Meredith; Liu, Jiqing; Bacosa, Hernando; Rosenheim, Brad E; Liu, Zhanfei

    2017-02-15

    An important aspect of oil spill science is understanding how the compounds within spilled oil, especially toxic components, change with weathering. In this study we follow the evolution of petroleum hydrocarbons, including n-alkanes, polycyclic aromatic hydrocarbons (PAHs) and alkylated PAHs, on a Louisiana beach and salt marsh for three years following the Deepwater Horizon spill. Relative to source oil, we report overall depletion of low molecular weight n-alkanes and PAHs in all locations with time. The magnitude of depletion, however, depends on the sampling location, whereby sites with highest wave energy have highest compound depletion. Oiled sediment from an enclosed bay shows high enrichment of high molecular weight PAHs relative to 17α(H),21β(H)-hopane, suggesting the contribution from sources other than the Deepwater Horizon spill, such as fossil fuel burning. This insight into hydrocarbon persistence as a function of hydrography and hydrocarbon source can inform policy and response for future spills.

  9. Tri-μ-ethanethiolato-bis{[η5-1,2,3,4-tetramethyl-5-(trimethylsilylcyclopentadienyl]iron(II,III}(FeII–FeIII

    Directory of Open Access Journals (Sweden)

    Jing Li

    2009-12-01

    Full Text Available The title complex, [Fe2(C2H5S3(C12H21Si2], has an unusual Fe2S3 core. The two 1,2,3,4-tetramethyl-5-(trimethylsilylcyclopentadienyl (Cp′ ligands coordinate to the Fe atoms with their C5 planes perpendicular [dihedral angles = 88.23 (7 and 88.55 (7°] to the Fe—Fe vector, building two Cp′Fe subunits. These two subunits are bridged by three thiolate ligands. There are no significant differences in the coordination geometries between the two Fe atoms. The short Fe—Fe distance of 2.7842 (5 Å is clear evidence of an intermetallic bond. Such a diiron–sulfur structure might act as a model of active sites in some metalloproteins.

  10. Bis(μ-diisopropylphosphanido-κ2P:Pbis[hydrido(triisopropylphosphane-κPplatinum(II

    Directory of Open Access Journals (Sweden)

    Nicole Arnold

    2012-06-01

    Full Text Available In the centrosymmetric molecular structure of the title compound [Pt2(C6H14P2H2(C9H21P2], each PtII atom is bound on one side to a phosphane ligand (PiPr3 and a hydrido ligand. On the other side, it is bound to two phosphanide ligands (μ-PiPr2, which engage a bridging position between the two PtII atoms, forming a distorted square-planar structure motif. The Pt...Pt distance is 3.6755 (2 Å. A comparable molecular structure was observed for bis(μ-di-tert-butylphosphanidobis[hydrido(triethylphosphaneplatinum(II] [Itazaki et al. (2004. Organometallics, 23, 1610–1621].

  11. The MSSM Spectrum from (0,2)-Deformations of the Heterotic Standard Embedding

    CERN Document Server

    Braun, Volker; Davies, Rhys; Donagi, Ron

    2011-01-01

    We construct supersymmetric compactifications of E_8 \\times E_8 heterotic string theory which realise exactly the massless spectrum of the Minimal Supersymmetric Standard Model (MSSM) at low energies. The starting point is the standard embedding on a Calabi-Yau threefold which has Hodge numbers (h^11,h^21) = (1,4) and fundamental group Z_12, which gives an E_6 grand unified theory with three net chiral generations. The gauge symmetry is then broken to that of the standard model by a combination of discrete Wilson lines and continuous deformation of the gauge bundle. On eight distinct branches of the moduli space, we find stable bundles with appropriate cohomology groups to give exactly the massless spectrum of the MSSM.

  12. N-[7-Ethoxy-1-(prop-2-en-1-yl-1H-indazol-4-yl]-4-methylbenzenesulfonamide

    Directory of Open Access Journals (Sweden)

    Najat Abbassi

    2011-07-01

    Full Text Available In the title compound, C19H21N3O3S, the C—SO2—NH—C torsion angle is 103.72 (11°. The almost planar indazole ring [r.m.s. deviation = 0.0202 (14 Å] is twisted away from the methylbenzene ring by 76.87 (7°. The vinyl group is disordered over two orientations with site occupancies of 0.622 (10 and 0.378 (10. The S atom has a distorted tetrahedral geometry [maximum deviation: O—S—O = 119.18 (11°]. An intramolecular C—H...O hydrogen bond occurs. In the crystal, two molecules are linked about a center of inversion by pairs of N—H...O hydrogen bonds, generating a dimer. C—H...π interactions are also observed.

  13. (±-N-[4-Acetyl-5-methyl-5-(4-methylcyclohex-3-enyl-4,5-dihydro-1,3,4-thiadiazol-2-yl]acetamide

    Directory of Open Access Journals (Sweden)

    Ahmed Benharref

    2008-03-01

    Full Text Available The new title thiadiazole compound, C14H21N3O2S, was semi-synthesized starting from 1-(4-methylcyclohex-3-enylethanone, a natural product isolated from Cedrus atlantica essential oil. The stereochemistry has been confirmed by single-crystal X-ray diffraction. The thiadiazoline ring is roughly planar, although it may be regarded as having a half-chair conformation. The cyclohexenyl ring has a half-chair conformation. The most interesting feature is the formation of a pseudo-ring formed by four molecules associated through N—H...O hydrogen bonds around a fourfold inversion axis, forming an R44(28 motif.

  14. (±)-N-[4-Acetyl-5-methyl-5-(4-methyl-cyclo-hex-3-en-yl)-4,5-dihydro-1,3,4-thia-diazol-2-yl]acetamide.

    Science.gov (United States)

    Mohammed, Tebbaa; Mazoir, Noureddine; Daran, Jean-Claude; Berraho, Moha; Benharref, Ahmed

    2008-02-20

    The new title thiadiazole compound, C(14)H(21)N(3)O(2)S, was semi-synthesized starting from 1-(4-methyl-cyclo-hex-3-en-yl)ethanone, a natural product isolated from Cedrus atlantica essential oil. The stereochemistry has been confirmed by single-crystal X-ray diffraction. The thia-diazo-line ring is roughly planar, although it may be regarded as having a half-chair conformation. The cyclo-hexenyl ring has a half-chair conformation. The most inter-esting feature is the formation of a pseudo-ring formed by four mol-ecules associated through N-H⋯O hydrogen bonds around a fourfold inversion axis, forming an R(4) (4)(28) motif.

  15. (R-2-[(Dimethylaminomethyl]-1,1′-bis(diphenylphosphinothioylferrocene dichloromethane monsolvate

    Directory of Open Access Journals (Sweden)

    Elisabeth Philippe

    2012-06-01

    Full Text Available In the title compound, [Fe(C20H21NPS(C17H14PS]·CH2Cl2, both cyclopentadienyl (Cp rings constituting the ferrocene unit are substituted by a sulfur-protected diphenylphosphine. One of the Cp ligands is additionally substituted by a dimethylaminomethyl group causing the chirality of the molecule. Surprisingly, although the synthetic procedure yielded the title compound as a racemic mixture, the reported crystal is enantiomerically pure with the R absolute configuration. The dimethylamino group is exo with respect to the Cp ring. Both diphenylthiophosphine groups are trans with respect to the centroid–Fe–centroid direction. Weak intramolecular C—H...S and C—H...π interactions between symmetry-related molecules are observed. The contribution of the disordered solvent was removed from the refinement using SQUEEZE in PLATON [Spek (2009. Acta Cryst. D65, 148–155].

  16. Variations of intestinal calcium absorption in adult frogs (Rana esculenta). Effect of lysine.

    Science.gov (United States)

    el Maraghi-Ater, H; Hourdry, J; Mesnard, J; Dupuis, Y

    1987-01-01

    Intestinal calcium absorption was investigated in an adult frog (Rana esculenta) by injecting a CaCl2 solution containing 45Ca into the lumen. The 45Ca absorption coefficient in the proximal loop was higher than in the distal loop, only when the CaCl2 solution was left for 4 h. This coefficient increased both in the proximal and distal loops when a 4-h treatment was substituted for a 1-h treatment. The coefficient increased in the whole intestine during the first 2 h of treatment (1 h: 21%; 2 h: 55%) and remained stable afterwards in our experimental conditions. The intestinal calcium absorption increase occurred early in the presence of L-lysine (100 mM), since the coefficient already reached its maximum value (52%) after a 1-h treatment.

  17. Bis[μ-N-(tert-butyldimethylsilylquinolin-8-aminato-1:2κ2N1,N8:N8](N,N,N′,N′-tetramethylethane-1,2-diamine-1κ2N,N′lithiumsodium

    Directory of Open Access Journals (Sweden)

    Juan Chen

    2012-12-01

    Full Text Available In the heterometallic title bulky amido complex, [LiNa(C15H21N2Si2(C6H16N2], both alkali metal ions are four-coordinated with distorted tetrahedral geometries. The Li+ ion is N,N′-chelated by the N-silylated amido ligand, with Li—N = 2.015 (5 and 2.074 (5 Å. The two amido ligands are arranged cis to each other. The molecule exhibits a twofold rotational symmetry operation along the Li–Na axis. The Na+ ion is coordinated by two N atoms from the tetramethylethylenediamine ligand [Na—N = 2.553 (4 Å] and shares two amido N atoms from the N-silylated amido ligands with the Li+ ion. Although the crystal structure contains voids with an approximate volume of 50 Å3 there is no inclusion of solvent molecules.

  18. 2-Benzylsulfanyl-N-(1,3-dimethylimidazolidin-2-ylideneaniline

    Directory of Open Access Journals (Sweden)

    Ulrich Flörke

    2013-04-01

    Full Text Available The molecular structure of the title compound, C18H21N3S, shows a twisted conformation with a dihedral angle of 67.45 (4° between the aromatic ring planes and an N—C—C—S torsion angle of −5.01 (13°. The imidazolidine ring and the aniline moiety make a dihedral angle of 56.03 (4° and the asscociated C—N—C angle is 125.71 (10°. The guanidine-like C=N double bond is clearly localized, with a bond length of 1.2879 (14 Å. The C—S—C angle is 102.12 (5° and the S—C(aromatic and S—C bond lengths are 1.7643 (11 and 1.8159 (12 Å.

  19. Chlorido[1-diphenylphosphanyl-3-(phenylsulfanylpropane-κ2P,S](η5-pentamethylcyclopentadienyliridium(III chloride monohydrate

    Directory of Open Access Journals (Sweden)

    Gerd Ludwig

    2012-06-01

    Full Text Available The crystal structure of the title compound, [Ir(C10H15Cl(C21H21PS]Cl·H2O, consists of discrete [Ir(η5-C5Me5Cl{Ph2P(CH23SPh-κP,κS}]+ cations, chloride anions and water molecules. The IrIII atom is coordinated by an η5-C5Me5 ligand, a chloride and a Ph2P(CH23SPh-κP,κS ligand, leading to a three-legged piano-stool geometry. In the crystal, two water molecules and two chloride anions are linked by weak O—H...Cl hydrogen bonding into tetramers that are located on centers of inversion. The H atoms of one of the methyl groups are disordered and were refined using a split model.

  20. Dicty_cDB: Contig-U05154-1 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available ( AC235776 ) Zonotrichia albicollis clone CH264-226A16, WORKIN... 52 0.021 1 ( AC169893 ) Macaca mulatta clone CH250-286A2, WORK...ING DRAFT S... 46 0.022 2 ( AC008452 ) Homo sapiens chromosome 5 clone CTC-345F2, WORKIN... musculus chromosome 5 clone RP23-286B6 map 5,... 50 0.084 1 ( AC129749 ) Rattus norvegicus clone CH230-50O23, WORK... AC099075 ) Rattus norvegicus clone CH230-41C6, WORKING DRAFT... 50 0.084 1 ( AC0...98172 ) Rattus norvegicus clone CH230-160H21, WORKING DRA... 50 0.084 1 ( AC096311 ) Rattus norvegicus clone CH230-126I16, WORK

  1. Dicty_cDB: CHQ694 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available clone RP11-849J9 map 18, WORKING DRAFT SEQUENCE, 3 unordered pieces. 44 2.0 1 AC154810 |AC154810.1 Mus muscu...lus chromosome 17 clone RP24-530D23, WORKING DRAFT SEQUENCE, 5 unordered pieces. ...44 2.0 1 AP001364 |AP001364.3 Homo sapiens genomic DNA, chromosome 18q12 clone:RP11-867A6, WORKING DRAFT SEQ... IN PROGRESS ***, 4 unordered pieces. 44 2.0 1 AC136530 |AC136530.2 Rattus norvegicus clone CH230-106H21, WORK... genomic DNA, chromosome 18q12 clone:RP11-849J9, WORKING DRAFT SEQUENCE, 31 unordered pieces. 44 2.0 1 AC094

  2. Dicty_cDB: VHC435 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available 2401 |AC012401.4 Homo sapiens chromosome 3 clone RP11-209H21 map 3, WORKING DRAFT...N PROGRESS ***, 45 unordered pieces. 46 0.53 1 AC156237 |AC156237.2 Bos taurus clone CH240-40A2, WORKING DRA...FT SEQUENCE, 16 unordered pieces. 46 0.53 1 AC152689 |AC152689.3 Bos taurus clone CH240-8B21, WORK...ING DRAFT SEQUENCE, 27 unordered pieces. 46 0.53 1 AC166516 |AC166516.3 Bos taurus clone CH240-172A2, WORK...ne TKIDN2001672, 5' end, mRNA sequence. 44 2.1 1 AC125297 |AC125297.3 Rattus norvegicus clone CH230-10D11, WORK

  3. Crystal structure of 1-(2,4-di-methyl-phen-yl)-2-(4-tri-methyl-silyl-1H-1,2,3-triazol-1-yl)ethanone.

    Science.gov (United States)

    Venkatesh, G B; Nagarajaiah, H; Prasad, N L; HariPrasad, S; Begum, Noor Shahina

    2014-12-01

    The asymmetric unit of the title compound, C15H21N3OSi, contains two mol-ecules with similar conformations (r.m.s. overlay fit for the 20 non-H atoms = 0.163 Å). The dihedral angles between the planes of the 1,2,3-triazole and 2,4-di-methyl-benzene rings are 27.0 (3) and 19.5 (3)°. In the crystal, mol-ecules are linked by very weak C-H⋯O and C-H⋯N hydrogen bonds to generate [100] chains. The chains are cross-linked by C-H⋯π inter-actions.

  4. The Lipopolysaccharide-induced metabolome signature in Arabidopsis thaliana reveals dynamic reprogramming of Phytoalexin and Phytoanticipin pathways

    CSIR Research Space (South Africa)

    Finnegan, T

    2016-09-22

    Full Text Available 2 [M-H]- C / L 6.91/9.68 Sulfoglucobrassicin (N-sulfoindol-3-yl)-methyl glucosinolate) 527.0106 4.10 C16H20N2O12S3 [M-H]- L 1.71 Aliphatic glucosinolates: precursors / intermediates 4-Methylthiobutanaldoxime 134.0561 1.85 C5H11NOS [M-H]- C - 2-Oxo-6... Cell / Medium / Leaf VIP score 2-Oxo-9-methylthiononanoate 217.0980 4.05 C10H17O3S [M-H]- C 2.96 9-Methylthiononanaldoxime 292.0963 10.25 C10H21NOS [M+FA +Na]- C 2.58 9-Methylthiononylhydroximoyl-L-cysteine 321.1380 6.66 C13H26N2O3S2 [M-H]- C / L 1.89/3...

  5. Lipopolysaccharide-induced metabolome signature in Arabidopsis thaliana reveals dynamic reprogramming of Phytoalexin and Phytoanticipin pathways

    CSIR Research Space (South Africa)

    Finnegan, T

    2016-09-01

    Full Text Available 2 [M-H]- C / L 6.91/9.68 Sulfoglucobrassicin (N-sulfoindol-3-yl)-methyl glucosinolate) 527.0106 4.10 C16H20N2O12S3 [M-H]- L 1.71 Aliphatic glucosinolates: precursors / intermediates 4-Methylthiobutanaldoxime 134.0561 1.85 C5H11NOS [M-H]- C - 2-Oxo-6... Cell / Medium / Leaf VIP score 2-Oxo-9-methylthiononanoate 217.0980 4.05 C10H17O3S [M-H]- C 2.96 9-Methylthiononanaldoxime 292.0963 10.25 C10H21NOS [M+FA +Na]- C 2.58 9-Methylthiononylhydroximoyl-L-cysteine 321.1380 6.66 C13H26N2O3S2 [M-H]- C / L 1.89/3...

  6. 4,4-Difluoro-2,3;5,6-bis(tetramethylene-4-bora-3a,4a-diaza-s-indacene (LD540

    Directory of Open Access Journals (Sweden)

    Kirsi Salorinne

    2014-01-01

    Full Text Available The title compound, C18H21BF2N2, is a lipophilic dye based on a BODIPY fluorophore backbone, which was developed for microscopic imaging of lipid droplets; the molecule has a planar BODIPY core [dihedral angle between the pyrrole rings = 2.3 (3°] and two tetramethylene substituents at the 2,3- and 5,6-positions in a half-chair conformation. One of the tetramethylene substituents is disordered over two two sets of sites with site occupancies of 0.5. In the crystal, pairs of C—H...F interactions link the molecules into inversion dimers. Neighbouring dimers are linked by further C—H...F interactions, forming an infinite array. C—H...π and π–π [centroid–centroid distance = 4.360 (3 Å] interactions are observed between the BODIPY core and the tetramethylene substituents of neighbouring dimer pairs.

  7. Bis{4-methylbenzyl 2-[4-(propan-2-ylbenzylidene]hydrazinecarbodithioato-κ2N2,S}nickel(II: crystal structure and Hirshfeld surface analysis

    Directory of Open Access Journals (Sweden)

    Enis Nadia Md Yusof

    2017-03-01

    Full Text Available The complete molecule of the title hydrazine carbodithioate complex, [Ni(C19H21N2S22], is generated by the application of a centre of inversion. The NiII atom is N,S-chelated by two hydrazinecarbodithioate ligands, which provide a trans-N2S2 donor set that defines a distorted square-planar geometry. The conformation of the five-membered chelate ring is an envelope with the NiII atom being the flap atom. In the crystal, p-tolyl-C—H...π(benzene-iPr, iPr-C—H...π(p-tolyl and π–π interactions [between p-tolyl rings with inter-centroid distance = 3.8051 (12 Å] help to consolidate the three-dimensional architecture. The analysis of the Hirshfeld surface confirms the importance of H-atom contacts in establishing the packing.

  8. Methyl (3R*,3′S*-1′,1′′-dimethyl-2,2′′-dioxodispiro[indoline-3,2′-pyrrolidine-3′,3′′-indoline]-4′-carboxylate

    Directory of Open Access Journals (Sweden)

    G. Ganesh

    2012-10-01

    Full Text Available In the title compound, C22H21N3O4, the central pyrrolidine ring adopts an envelope conformation with the N atom in the flap position. The indoline ring systems are almost perpendicular to the mean plane of the pyrrolidine ring, making dihedral angles of 86.4 (8 and 83.1 (8°. The acetate group attached to the pyrrolidine ring assumes an extended conformation. In thecrystal, N—H...O hydrogen bonds result in the formation of a C(7 chain running along [100]. The crystal packing also features π–π interactions [centroid–centroid distance = 3.2032 (11 Å].

  9. Crystal structure of (E-1-{2-[(5,5-dimethyl-1,3,2-dioxaphosphinan-2-yloxy]naphthalen-1-yl}-N-(4-fluorophenylmethanimine

    Directory of Open Access Journals (Sweden)

    Musa A. Said

    2015-01-01

    Full Text Available In the title compound, C22H21FNO3P, a 1,3,2-dioxaphosphinan-2-yloxy derivative, three O atoms are bonded in a trigonal–pyramidal manner to the P atom. The exocyclic P—O bond is significantly longer than the two endocyclic P—O bonds, viz. 1.6678 (12 Å compared to 1.6046 (13 and 1.6096 (12 Å. The six-membered ring which includes the P atom has a chair conformation. The fluorophenyl ring is inclined to the naphthalene ring system by 24.42 (7°. In the crystal, molecules are linked via C—H...π interactions, forming slabs lying parallel to (10-1.

  10. (2E-3-(6-Chloro-2-methoxyquinolin-3-yl-1-(2-methyl-4-phenylquinolin-3-ylprop-2-en-1-one acetone monosolvate

    Directory of Open Access Journals (Sweden)

    Edward R. T. Tiekink

    2013-08-01

    Full Text Available In the title solvate, C29H21ClN2O2·C3H6O, a prop-2-en-1-one bridge links two quinolinyl residues; the latter are almost perpendicular [dihedral angle = 78.27 (6°]. The dihedral angle between the quinonyl ring system and its pendant phenyl group is 59.78 (8°. A small twist in the bridging prop-2-en-1-one group is noted [O=C—C=C torsion angle = −10.6 (3°]. In the crystal, a three-dimensional architecture arises as a result of C—H...O and π–π stacking [centroid–centroid distances = 3.5504 (12–3.6623 (12 Å].

  11. Methyl trans-(±-1-oxo-2-phenethyl-3-(thiophen-2-yl-1,2,3,4-tetrahydroisoquinoline-4-carboxylate

    Directory of Open Access Journals (Sweden)

    Mehmet Akkurt

    2009-06-01

    Full Text Available In the title compound, C23H21NO3S, the piperidine ring of the tetrahydroisoquinolinone unit adopts a screw-boat conformation. The thiophene ring is disordered in a 0.700 (3:0.300 (3 ratio by an approximate 180° rotation of the ring around the C—C bond linking the ring to the tetrahydroisoquinolinone unit. The benzene ring of the tetrahydroisoquinolinone unit makes dihedral angles of 83.1 (2 and 62.38 (11° with the major occupancy thiophene ring and the phenyl ring, respectively. The dihedral angle between the phenyl ring and the thiophene ring is 71.0 (2°. In the crystal structure, molecules are linked together by intermolecular C—H...O and C—H...π interactions.

  12. Functional studies of the gene slr2049 from Synechocystis sp. PCC6803 and its site-directed mutation.

    Science.gov (United States)

    Liu, Bingjun; Chen, Sili; Zhang, Lei

    2015-06-01

    Phycobiliprotein is a homologous family of light-harvesting chromoproteins existing in cyanobacteria, red algae and cryptophytes. Phycobiliprotein is made up of phycobilin and its corresponding apophycobiliprotein, and they are covalently linked by the thioether bond with the bilin lyase. Using the software BLAST, we have found gene slr2049 in Synechocystis sp. PCC6803 homologous to the biliprotein lyase gene cpeS. This paper investigates the protein expressed by gene slr2049 to find the enzymatic activity characteristics. We cloned slr2049 and its related genes cpcB, ho1, and pcyA which are linked with the synthesis of phycocyanin. Special amino acid mutagenesis was performed on slr2049 to construct eight mutants slr2049 (H21S), slr2049 (L23S), slr2049 (A24S), slr2049 (F25S), slr2049 (W72L), slr2049 (G84S), slr2049 (R107S) and slr2049 (Y124S). These mutants were ligated with vectors pEDFDuet-1 and pET-23a to construct pCDF-cpcB-slr2049 wild-type, pCDF-cpcB-slr2049 mutants and pET-ho1-pcyA, for the purpose of protein expression and analysis. The results showed that the wild-type and mutants slr2049 (H21S), slr2049 (L23S), slr2049 (F25S), slr2049 (W72L), slr2049 (G84S), and slr2049 (Y124S) can catalyze CpcB to couple on PCB correctly and the products have unique spectral characteristics. However mutants slr2049 (A24S) and slr2049 (R107S) have no spectral characteristics. Thus, it is suggested that alanine at position 24 and arginine at position 107 are the active sites.

  13. Estimation of wave characteristics during hurricane in the Hoian area, central Vietnam

    Digital Repository Service at National Institute of Oceanography (India)

    Mau, L.D.; SanilKumar, V.; Nayak, G.N.; Mandal, S.

    .5 20.6 5.7 187.6 4.6 9.4 2 12h/08/10/1955 15.7 108.6 12.9 3.7 149.5 2.5 7.4 3 18h/14/04/1956 15.3 109.0 10.3 5.2 119.2 1.8 6.4 4 6h/12/10/1957 15.5 108.5 33.4 5.2 264.8 8.8 12.4 5 0h/15/9/1964 15.7 108.3 38.6 6.4 281.5 10.5 13.3 6 0h/27/9/1964 16.../09/1984 15.5 108.6 12.8 5.2 138.5 2.4 7.2 12 18h/21/10/1986 15.2 108.8 25.7 4.7 226.6 6.3 10.8 13 18h/24/5/1989 15.8 108.6 36.0 3.1 263.5 9.4 12.7 14 18h/21/10/1996 15.5 108.8 13.0 3.6 150.3 2.6 7.5 15 0h/25/9/1997 15.5 108.8 38.6 3.1 271.9 10.3 13.2 16...

  14. Profile of Shiga toxin-producing Escherichia coli strains isolated from dogs and cats and genetic relationships with isolates from cattle, meat and humans.

    Science.gov (United States)

    Bentancor, A; Rumi, M V; Carbonari, C; Gerhardt, E; Larzábal, M; Vilte, D A; Pistone-Creydt, V; Chinen, I; Ibarra, C; Cataldi, A; Mercado, E C

    2012-05-04

    Pets can be reservoirs of Shiga toxin-producing Escherichia coli (STEC) strains. The aim of this study was to examine nine strains belonging to several serotypes (O91:H21, O91:H16, O178:H19, O8:H19, O22:H8, O22:HNT, ONT:H8), previously recovered from cats or dogs. To this end, we assessed a set of additional virulence genes (stx(2) subtype, subAB, ehxA, eae and saa), cytotoxic activity, and genetic relationships with strains isolated from cattle, meat and humans using pulsed-field gel electrophoresis (PFGE). Most of the isolates carried the stx(2) and/or stx(2vh-b) sequences, while only the O91:H21 isolate presented the mucus-activatable stx(2d) variant, as confirmed by sequencing the genes of subunits A and B. All the strains showed cytotoxic activity in cultured cells. One of the two O178:H19, selected for its high level of cytotoxicity in Vero cells, showed the ability to cause functional alterations in the human colon mucosa in vitro. None of the strains possessed the subAB, eae or saa genes and only the strains belonging to serotype O8:H19 carried the ehxA gene. The isolates shared 90-100% similarity by PFGE to epidemiologically unrelated strains of the corresponding serotypes recovered from cattle, meat or humans. Our results demonstrate that dogs and cats may have a role in the infection of humans by STEC, probably serving as a vehicle for bovine strains in the cycle of human infection, and thus emphasize the health risks for owners and their families. Copyright © 2011 Elsevier B.V. All rights reserved.

  15. Solid pole tide in global GPS and superconducting gravimeter observations: Signal retrieval and inference for mantle anelasticity

    Science.gov (United States)

    Ding, Hao; Chao, Benjamin F.

    2017-02-01

    The mantle anelasticity plays an important role in Earth's interior dynamics. Here we seek to determine the lower-mantle anelasticity through the solution of the complex Love numbers at the Chandler wobble period. The Love numbers h21, l21, δ21 and k21 are obtained in the frequency domain by dividing off the observed polar motion, or more specifically the pole tide potential, from the observed GPS 3-D displacement field and SG gravity variation. The latter signals are obtained through the array processing method of OSE (optimal sequence estimation) that results in greatly enhanced signals to be extracted from global array data. The resultant Love number estimates h21 = 0.6248 (± 5 e - 4) - 0.013 (± 5 e - 3) i, l21 = 0.0904 (± 8 e - 4) - 0.0008 (± 2 e - 3) i, δ21 = 1.156 (± 2 e - 3) - 0.003 (± 1 e - 3) i and k21 = 0.3125 (± 2 e - 3) - 0.0069 (± 3 e - 3) i are thus well-constrained in comparison to past estimates that vary considerably. They further lead to estimates of the corresponding mantle anelastic parameters fr and fi, which in turn determines, under the single-absorption band assumption, the dispersion exponent of α = 0.21 ± 0.02 with respect to the reference frequency of 5 mHz. We believe our estimate is robust and hence can better constrain the mantle anelasticity and attenuation models of the Earth interior.

  16. Phylogenetic and molecular analysis of food-borne shiga toxin-producing Escherichia coli.

    Science.gov (United States)

    Hauser, Elisabeth; Mellmann, Alexander; Semmler, Torsten; Stoeber, Helen; Wieler, Lothar H; Karch, Helge; Kuebler, Nikole; Fruth, Angelika; Harmsen, Dag; Weniger, Thomas; Tietze, Erhard; Schmidt, Herbert

    2013-04-01

    Seventy-five food-associated Shiga toxin-producing Escherichia coli (STEC) strains were analyzed by molecular and phylogenetic methods to describe their pathogenic potential. The presence of the locus of proteolysis activity (LPA), the chromosomal pathogenicity island (PAI) PAI ICL3, and the autotransporter-encoding gene sabA was examined by PCR. Furthermore, the occupation of the chromosomal integration sites of the locus of enterocyte effacement (LEE), selC, pheU, and pheV, as well as the Stx phage integration sites yehV, yecE, wrbA, z2577, and ssrA, was analyzed. Moreover, the antibiotic resistance phenotypes of all STEC strains were determined. Multilocus sequence typing (MLST) was performed, and sequence types (STs) and sequence type complexes (STCs) were compared with those of 42 hemolytic-uremic syndrome (HUS)-associated enterohemorrhagic E. coli (HUSEC) strains. Besides 59 STs and 4 STCs, three larger clusters were defined in this strain collection. Clusters A and C consist mostly of highly pathogenic eae-positive HUSEC strains and some related food-borne STEC strains. A member of a new O26 HUS-associated clone and the 2011 outbreak strain E. coli O104:H4 were found in cluster A. Cluster B comprises only eae-negative food-borne STEC strains as well as mainly eae-negative HUSEC strains. Although food-borne strains of cluster B were not clearly associated with disease, serotypes of important pathogens, such as O91:H21 and O113:H21, were in this cluster and closely related to the food-borne strains. Clonal analysis demonstrated eight closely related genetic groups of food-borne STEC and HUSEC strains that shared the same ST and were similar in their virulence gene composition. These groups should be considered with respect to their potential for human infection.

  17. Research of Catalytic Oxidation of 2-mercaptoethanol by Asymmetric Phthalocyanine Cobalt%非对称酞菁钴催化氧化2-巯基乙醇的研究

    Institute of Scientific and Technical Information of China (English)

    梁雅秋; 潘玲玲; 单秋杰; 吴迪; 陈伟

    2015-01-01

    采用统计缩合法合成三种不对称酞菁钴———2-(对羧基苯氧基)-9,10,16,17,23,24-六烷氧基酞菁钴(Ⅱ)CoPc (n-C4 H9, n-C5 H11, n-C10 H21)( a, b, c)。研究了催化剂对2-巯基乙醇的催化氧化性能。探讨了催化剂种类、催化剂用量对2-巯基乙醇催化氧化反应的影响。实验结果表明:在相同的催化条件下,三种催化剂均表现出良好的催化性能,在60 min内,能将0.10 mol· L-1的2-巯基乙醇氧化77%。%Three novel asymmetrical phthalocyanines cobalt (Ⅱ) , 2-( p-carboxylphenoxy )-9 ,10 ,16 ,17 ,23 ,24-hexaalkoxyphthalocyanine cobalt(Ⅱ)[(RO)6(OphCOOH)PcCo(Ⅱ)](R=n-C4H9, n-C5H11, n-C10H21)(a,b,c), were synthesized by statistical condensation method.The catalytic performance of catalysts for 2-mercaptoethanol , effects of catalyst type , catalyst dosage on the catalytic oxidation of 2-mercaptoethanol were studied.The experimental results showed that three kinds of catalysts showed good catalytic performance in the same catalytic conditions , the 0.10 mol· L-1 2-mercaptoethanol of 77%was oxidized in the 60 min.

  18. Characteristics of hopanoid hydrocarbons in ambient PM₁₀ and motor vehicle emissions and coal ash in Taiyuan, China.

    Science.gov (United States)

    Han, Feng; Cao, Junji; Peng, Lin; Bai, Huiling; Hu, Dongmei; Mu, Ling; Liu, Xiaofeng

    2015-10-01

    Hopanoid hydrocarbon content in ambient particulate matter (PM) of less than or equal to 10 μm aerodynamic diameter (PM10) was sampled at seven sites representative of different functional districts, and measured by gas chromatography-mass spectrometry. 17α(H),21β(H)-hopane (C30αβ) and 17α(H),21β(H)-30-norhopane (C29αβ) were dominant in all samples. Hopanes in motor vehicle emissions from various fuel-type engines (gasoline, diesel and natural gas) and coal ash were qualitatively measured, and the amount of C30αβ was about two to three times greater than that of C29αβ. Distinct seasonal variations (winter/summer differences) were observed at higher concentrations (45.54-108.29 ng/m(3)) of total hopanes in winter and lower (2.59-28.26 ng/m(3)) in summer. There were also clear spatial variations of hopanes in Taiyuan, with samples with greater hopane concentrations in downtown areas, but less in summer. The spatial distribution reversed in winter. Distributions and relative abundances of selected hopanes from PM10 and source emissions indicated that in summer, vehicle exhaust was the dominant fossil fuel combustion source (C30αβ was >C29αβ), and that the contribution of coal combustion was slightly greater at suburban sites. However, the contribution of coal combustion sources increased significantly at all sites in winter, especially in suburban areas, where C29αβ exceeded C30αβ. Hopanoid indexes revealed a classification of vehicle exhaust and coal combustion emissions in PM10. The results imply that during rapid urbanization, it is crucial to strengthen the construction of infrastructure such as central heating in new city districts and to increase the use of natural gas instead of residential coal burning.

  19. On the Significance of Bacterial triterpenic Biomarkers in Sediments

    Science.gov (United States)

    Rohmer, M.

    2004-12-01

    Triterpenic biomarkers are ubiquitous in the organic matter of sediments. Bacterial contribution is essential for several series. Despite the numerous investigations performed over the last decades, little is known about the distribution of triterpenoids in Eubacteria. An updated survey of triterpene distribution in Eubacteria points out a much broader diversity of the structures than expected ten years ago. Hopanoids characterized by their C35 skeleton resulting from a carbon/carbon linkage between the triterpene hopane skeleton and a D-ribose derivative are the most frequent ones. Their distribution cannot be readily interpreted and may result from lateral gene transfer. Many groups, such as strict anaerobes, are underrepresented in the screenings, mainly because of the complex techniques required for their growth. Most of the bacterial hopanoids belong to the (17α H,21β H) series, corresponding to the stereochemistry of hopanoid biomarkers from non-mature sediments. (17β H,21α H)- and especially (17α ,21β H)-hopanoids are derived from the former series via diagenesis and maturation of the organic matter. Both series were, however, recently found in widespread soil bacteria (Frankia spp., Geodermatophilus spp.) questioning at least partially their significance as maturation indicators. Quasi-hopanoids with the gammacerane skeleton were first found in ciliate protozoa. They are also present in high concentrations in the phylogenetically related bacteria Rhodopseudomonas palustris and all Bradyrhizobium spp. In all closely investigated hopanoid producing bacteria, a complex mixture of triterpene hydrocarbons accompanied in small amounts hop-22(29)-ene. They include pentacyclic triterpenes (rearranged hopenes, fernenes) as well as tetracyclic triterpenes (dammaradienes, euphadienes) and result from a lack of strict control of the cyclization process by the squalene/hopene cyclase. Triterpenoids related to sterol biosynthesis (lanosterol, cycloartenol) have

  20. Electrocardiography and echocardiography in athletic heart imagining

    Directory of Open Access Journals (Sweden)

    D Biały

    2003-03-01

    Full Text Available The aim of the study was evaluation of electrocardiographic and echocardiographic parameters in athletes. „Athletic heart” characteristics were compared with fit persons’ heart. 96 athletes participated in the study. Sportsmen were divided into: static (S, dynamic (D and composite (SD exercise groups and Polish (I, European (II, World (III champions. 30 students from Sport Academy formed the control group (K. Electrocardiographic and echocardiographic examination were performed in everyone. As regards the type of exercise, the end-systolic left ventricular (LV dimension was smaller in S in comparison with D and SD (28.9 vs 32.2 and 32.68 mm; P<0.05. LV mass was bigger in D in comparison with K (273.2 vs 218.6 g; P<0.05. Medium Pulmonary Artery Pressure (MPAP in S and SD was lower in respect to D and K (11.75; 11.08 vs 15.52; 17.43 mm Hg; P<0.05. We observed lower heart rate in D, SD in comparison with K (58.64; 60.54 vs 68.8; P<0.05, bigger R wave amplitude in V5 (RV5 (21.65; 23.5 vs 15.03 mm; P<0.05 and V6 (RV6 (23.5 vs 15.3 mm; P<0.05 in group S in respect to K. LV mass was bigger in III than in K (261.3 vs 218.6 g; P<0.05. MPAP was lower in I and II in comparison with K (11.42; 13.13 vs 17.43 mmHg; P<0.05. HR was lower in categories I, II than in K (61.32; 60.13 vs 68.8; P<0.05, RV5 was bigger in I in comparison with K (19.5 vs 15.03 mm; P<0.05. The electrocardiography and echocardiography proves to find some significant differences between athletic and fit persons’ heart especially as concerns MPAP, RV5, RV6 values.

  1. Export of soil macronutrients in area cultivated with maize to feeding feedlot steers

    Directory of Open Access Journals (Sweden)

    Robson Kyoshi Ueno

    2013-12-01

    Full Text Available The maize cultivated for forage requires special care with soil management. The nutrients exportation by silage might cause reducing of soil fertility, with consequent decrease of yield and nutritional quality of posterior crops. The aim of this work was assess levels of macronutrients in maize plant fragments (stem, leaves, bracts plus cob and grains, at stage of ensilage, in entire plant (silage forage and in the mature grains; measure the nutrients exportation from soil by forage or grains. After, two diets were used in feedlot cattle, first was based on silage and other based in grains, to appraise the potential of nutrients to return into soil by manure and the final account of nutrients balance. The levels of N, P, K, Ca and Mg from forage were, respectively: 1,37; 0,24; 0,81; 0,2 and 0,22%; and in grains: 1,8; 0,28; 0,34; 0,12; and 0,11%. The fertilization performed was enough to supply extracted nutrients when was harvested only grains, promoting deficits in soil of 93 kg ha-1 of N and 84 kg ha-1 of K when was harvested forage. The manure of animals feed with silage+concentrated, compared to diet without roughage (80% grains and 20% protein core, cycled different amounts of N (276,28 vs 59,37, P (128,12 vs 33,37, K (58,32 vs 5,38, Ca (177,7 vs 78,89 and Mg (43,64 vs 11,81 in the cultivated area. The evaluated production systems presented capacity to maintain the levels of nutrients at soil through replacement via manure, and might contribute to the enrichment of fertility and reduce costs with mineral fertilizers in successive crops. The system which forage was used presented deficit of 25 kg ha-1 de K, probably due to insufficient amount of K applied, which recommendation is frequently made to grain production.

  2. Quasi-2D characteristics in the ac susceptibility response of polycrystalline (Bi,Pb)SrCaCuO/2223 multiphase systems

    Energy Technology Data Exchange (ETDEWEB)

    Mihalache, V. [Department of Low Temperature Physics and Superconductivity, National Institute for Materials Physics, POB MG-7, 077125 Bucharest-Magurele (Romania)], E-mail: vmihal@infim.ro; Cosereanu, L. [METRA, P.O. Box 51-16, 076550 Bucharest (Romania); Miu, L. [Department of Low Temperature Physics and Superconductivity, National Institute for Materials Physics, POB MG-7, 077125 Bucharest-Magurele (Romania)

    2008-01-01

    Fundamental and third harmonic ac susceptibility measurements as a function of temperature T, ac magnetic field, and dc magnetic field have been performed on Bi(Pb)SrCaCuO/2223 bulk samples consisting of both Bi{sub 2}Sr{sub 2}Ca{sub 2}Cu{sub 3}O{sub 10+{delta}} (2223) and Bi{sub 2}Sr{sub 2}CaCu{sub 2}O{sub 8+{delta}} (2212) phases. Since the {chi}{sub 1}{sup ''}(T) peak corresponding to the losses in the weak links between the grains shifts rapidly to lower T and its amplitude is strongly suppressed with increasing the dc magnetic field H{sub dc}, the other peaks related to the losses in the grains become visible. For the samples consisting of single phase 2223, these intragranular peaks are situated near 38 K, 58 K, and 80-88 K (depending on the sample), whereas for the samples consisting of single phase 2212, they are situated near 20 K, 43 K, and 77 K. For H{sub dc} {>=} 1 kOe, the temperature positions of the intragranular peaks are weakly field dependent. This shows that the transition line determined from the loss peaks behaves like the melting line in two-dimensional (2D) systems. Also, as the field increases, the amplitude of the loss peaks can decrease up to their disappearance, suggesting a layer decoupling process. In this way, we show that, above a crossover field of {approx}1 kOe, the vortex lattice in the superconducting grains of polycrystalline samples reproduces the behaviour of the vortex lattice in a quasi-2D object consisting of a set of separated 'thin films' with one-, two-, and three-effective-layer thicknesses. For the samples consisting of both 2223 and 2212 phases, three additional peaks were observed, situated near 28 K, 50 K and 75-80 K (depending on the sample). These peaks were attributed to the regions in which the 2212 and 2223 layers alternate.

  3. Isolation and characterization of non-O157 Shiga toxin-producing Escherichia coli from beef carcasses, cuts and trimmings of abattoirs in Argentina

    Science.gov (United States)

    Brusa, Victoria; Restovich, Viviana; Galli, Lucía; Teitelbaum, David; Signorini, Marcelo; Brasesco, Hebe; Londero, Alejandra; García, Diego; Padola, Nora Lía; Superno, Valeria; Sanz, Marcelo; Petroli, Sandra; Costa, Magdalena; Bruzzone, Mariana; Sucari, Adriana; Ferreghini, Marcela; Linares, Luciano; Suberbie, Germán; Rodríguez, Ricardo

    2017-01-01

    Several foods contaminated with Shiga toxin-producing Escherichia coli (STEC) are associated with human diseases. Some countries have established microbiological criteria for non-O157 STEC, thus, the absence of serogroups O26, O45, O103, O104, O111, O121, and O145 in sprouts from the European Union or ground beef and beef trimmings from the United States is mandatory. While in Argentina screening for O26, O103, O111, O145 and O121 in ground beef, ready-to-eat food, sausages and vegetables is mandatory, other countries have zero-tolerance for all STEC in chilled beef. The aim of this study was to provide data on the prevalence of non-O157 STEC isolated from beef processed in eight Argentinean cattle slaughterhouses producing beef for export and local markets, and to know the non-O157 STEC profiles through strain characterization and genotypic analysis. Samples (n = 15,965) from 3,205 beef carcasses, 9,570 cuts and 3,190 trimmings collected between March and September 2014 were processed in pools of five samples each. Pools of samples (n = 3,193) from 641 carcasses, 1,914 cuts and 638 trimming were analyzed for non-O157 STEC isolation according to ISO/CEN 13136:2012. Of these, 37 pools of carcasses (5.8%), 111 pools of cuts (5.8%) and 45 pools of trimmings (7.0%) were positive for non-O157 STEC. STEC strains (n = 200) were isolated from 193 pools of samples. The most prevalent serotypes were O174:H21, O185:H7, O8:H19, O178:H19 and O130:H11, and the most prevalent genotypes were stx2c(vh-b) and stx2a/saa/ehxA. O103:H21 strain was eae-positive and one O178:H19 strain was aggR/aaiC-positive. The prevalence of non-O157 STEC in beef carcasses reported here was low. None of the non-O157 STEC strains isolated corresponded to the non-O157 STEC serotypes and virulence profiles isolated from human cases in Argentina in the same study period. The application of microbiological criteria for each foodstuff should be determined by risk analysis in order to have a stringent

  4. Chemical composition of PM2.5 from two tunnels with different vehicular fleet characteristics.

    Science.gov (United States)

    Cui, Min; Chen, Yingjun; Tian, Chongguo; Zhang, Fan; Yan, Caiqing; Zheng, Mei

    2016-04-15

    The chemical compositions of PM2.5 including OC, EC, water soluble ions, elements, and organic components such as polycyclic aromatic hydrocarbons (PAHs), hopanes, and steranes, emitted in Wuzushan (WZS) and Kuixinglou (KXL) tunnels were determined. WZS tunnel is a major route for diesel vehicles traveling, while KXL tunnel has limited to diesel vehicles. The results showed that the proportions of the different constituents of PM2.5 in the Wuzushan (WZS) tunnel were OC (27.7%), EC (32.1%), elements (13.9%), and water soluble ions (9.2%). Whereas the chemical profile of PM2.5 in the Kuixinglou (KXL) tunnel was OC (17.7%), EC (10.4%), elements (8.90%), and water soluble ions (8.87%). The emission factors (EFs) of PM2.5 and proportions of SO4(2-) and Pb were decreased by vehicle emission standards and fuel quality policy in China, and the higher molecular weight PAHs (4+5+6 rings) were more abundant than the lower molecular weight PAHs (2+3 rings) in the two tunnels. The proportions of 17A(H)-21B(H)-30-Norhopane and 17A(H)-21B(H)-Hopane in the hopane and sterane were not dependent on the vehicles types. In addition, specific composition profiles for PM2.5 from gasoline-fueled vehicles (GV) and diesel-fueled vehicles (DV) emissions were drafted, which indicated that OC (0.974mg·veh(-1)·km(-1)) was the most abundant component in PM2.5, followed by Fe, Cl(-), and Mg for GV. The relative proportions of the different constituents in the PM2.5 for DV were EC (35.9%), OC (27.2%), elements (12.8%), and water soluble ions (11.7%). Both the PM2.5 EFs and EC proportions in DV were higher than those in GV, and the HMW PAHs were the dominant PAHs for both GV and DV. The PM2.5 emissions from the vehicles in Yantai were 581±513tons to 1353±1197tons for GV, and 19,627±2477tons to 23,042±2887tons for DV, respectively.

  5. Hadron rich and Centauro events

    Energy Technology Data Exchange (ETDEWEB)

    Barroso, S.L.C. [Centro Brasileiro de Pesquisas Fisicas, 22290-180 Rio de Janeiro, RJ (Brazil); Beggio, P.C. [Laboratorio de Ciencias Matematicas, UENF, Campos de Goytacazes, RJ (Brazil); Carvalho, A.O. de; Chinellato, J.A.; Mariano, A.; Oliveira, R. de; Shibuya, E.H. [Instituto de Fisica ' Gleb Wataghin' /UNICAMP, 13083-970 Campinas, SP (Brazil)

    2008-01-15

    An exploratory statistical analysis of the event C16S086I037 was possible to do using two simulations. A {gamma} and hadron induced showers recognition done on this event through a best fitting procedure shows identification of 25 and 37 for {gamma} and hadron induced showers, respectively. Assuming that the most energetic shower is the surviving particle of an interaction and the tertiary produced particles are from normal multiple pion production, the characteristics of the interaction are: Energy of primary particle E{sub 0}=1,061 TeV, Inelasticity of collision K=0.81, Mean inelasticity of {gamma}-ray =0.27, Hadron induced showers energy/Total energy Q{sub h}{sup '}=0.90{approx}Q{sub h}, Rapidity density N{sub h}/{delta}Y=(8.56-9.89), Mean energy of secondary hadrons h}>=(21.5{+-}4) TeV, Mean transverse momentum =(1.2{+-}0.2) GeV/c, Upper bound of partial cross section {sigma}{<=}(15-39){mu}barn and life time {tau}{<=}10{sup -16} s. Without the surviving particle assumption, the values are: E{sub 0}=873 TeV, K=1.0, =1/3, Q{sub h}{sup '}=0.90, N{sub h}/{delta}Y=(8.32-9.34), h}>=(21{+-}3.5) TeV, =(1.0{+-}0.16) GeV/c. Using another simulation for energy determination with {chi}{sup 2}>3.16 for best fitting results 22 and 40 for {gamma} and hadron induced showers, respectively. Under the surviving particle assumption, the figures are: Energy of primary particle E{sub 0}=1,047 TeV, Inelasticity of collision K=0.80, Mean inelasticity of {gamma}-ray =0.27, Hadronic induced showers energy/Total energy Q{sub h}{sup '}=0.89{approx}Q{sub h}, Rapidity density N{sub h}/{delta}Y=(10.25-13.19), Mean energy of secondary hadrons =(19{+-}3) TeV, Mean transverse momentum =(1.0{+-}0.2) GeV/c. That is, we get almost similar figures independently of simulation and a mean transverse momentum for this hadron-rich event similar to the Centauro events.

  6. α-氰基-α-二茂铁基乙氧三甲硅烷的合成与晶体结构%Synthesis and Crystal Structure of a Novel Compound-α-cyano-α-ferrocenylethoxytrimethylsilane

    Institute of Scientific and Technical Information of China (English)

    王晓丽; 边占喜; 包华影

    2007-01-01

    乙酰基二茂铁与三甲基氰硅烷在CH2Cl2中ZnI2催化下加成,得到产率较高的α-氰基-α-二茂铁基乙氧三甲硅烷,用元素分析、IR和1H NMR进行了表征.经X射线单晶衍射法测试表明,该化合物属正交晶系,Pbca空间群,晶胞内分子数为8,化合物分子式为C16H21FeNOSi,Mr=327.28,a=1.1995(4)nm,b=1.2441(4)m,c=2.2183(7)nm,β=90°,V=3.3103(18)nm3,Dcale=1.313g·cm-3,Z=8,最终偏离因子R=0.0456,ωR=0.0880.分析其结构表明,该化合物含有一个二茂铁基和氰基乙氧三甲基硅烷基,与二茂铁基相连的碳原子是手性原子,分子中存在超共轭效应.%The title compound, α-cyano-α-ferrocenylethoxytrimethylsilane(C16 H21 FeNOSi,Mr=327.28),was synthesised by the reaction of adding trimethysilyl cynide to acetyfferrocene, in the presence of ZnI2 in CH2 Cl2, and characterized by1H NMR, IR and elemental analysis. The crystal structure was determined by X-ray diffraction methods. The compound crystallises in the orthorhombic space group Pbca, with the cell dimensions of a=1.1995 (4)nm,b = 1.2441 (4) nm,c=2.2183(7)nm,β =90°,V=3.3103 (18)nm3,Z=8,Dcacl =1.313g· cm-3,λ =0. 071073nm,μ(MoKα) =0. 979mm-1 and F(000) =1376. The structure was refined to R =0. 0456 and ωR =0. 0880 for 2148 observed reflections with I>2σ(I). The molecule consists of a ferrocene unit and an ethoxytrimethysilane group and a super conjugate effect may exist in the title compound.

  7. The impact of Deepwater Horizon oil spill on petroleum hydrocarbons in surface waters of the northern Gulf of Mexico

    Science.gov (United States)

    Liu, Zhanfei; Liu, Jiqing; Gardner, Wayne S.; Shank, G. Christopher; Ostrom, Nathaniel E.

    2016-07-01

    This study evaluated impacts of the BP Deepwater Horizon (DWH) oil spill on petroleum hydrocarbons in surface waters of the Louisiana continental shelf in northern Gulf of Mexico. Surface water ( top 5 cm) without visible oil was collected from three cruises in May 2010 during the oil spill, August 2010 after the well was capped, and May 2011 one year after the spill. Concentrations of total dissolved n-alkanes (C9-C35) in surface seawater were more than an order of magnitude higher in May 2010 than August 2010 and May 2011, indicating contamination by the DWH oil spill. This conclusion was further supported by more abundant smaller n-alkanes (C9-C13), together with pristane and phytane, in May than August 2010 samples. In contrast, even carbon-numbered dissolved n-alkanes (C14-C20) dominated the May 2011 samples, and this distribution pattern of dissolved n-alkanes is the first documentation for water samples in the northern Gulf of Mexico. However, this pattern was not observed in May 2011 suspended particles except for Sta. OSS. This decoupling between dissolved and particle compositions suggests that either these even carbon-numbered n-alkanes originated from bacteria rather than algae, or that the alkanes in the shelf were transported from elsewhere. Concentrations of polycyclic aromatic hydrocarbons (PAHs) in suspended particles were 5 times higher on average in May 2010 (83-252 ng L-1) than May 2011 (7.2-83 ng L-1), also indicating contamination by the DWH oil spill. Application of a biomarker ratio of 17α(H),21β(H)-30-norhopane over 17α(H),21β(H)-hopane confirmed that suspended particles from at least two stations were contaminated by the DWH oil spill in May 2010. Taken together, these results showed that surface waters of the sampling area in May 2010 were contaminated by the oil spill, but also that rapid weathering and/or physical dilution quickly reduced hydrocarbon levels by August 2010.

  8. Preparation of Monoclonal Antibody and Development of Enzyme-linked Immunosorbent Assay Specific for Escherichia coli O157 in Foods

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    Objective To prepare monoclonal antibodies (Mab) and antisera specific for Escherichia coli (E.coli) O157, and to develop a sandwich enzyme-linked immunosorbent assay (ELISA) to detect E.coli O157 in foods. Methods Spleen cells from BALB/c mice immunized with the somatic antigen of E.coli O157:H7 were fused with murine Sp2/0 myeloma cells. The hybridoma cell line specific for E.coli O157 was established after having been subcloned. Antisera specific for E.coli O157 was prepared by intravenous injection into New Zealand rabbits with a stain of E.coli O157:H7. The sandwich ELISA was developed with the polyclonal antibody as the capture antibody and the Mab 3A5 as the detection antibody. The inoculated ground poultry meat and pasteurized milk were tested to confirm efficiency of the method. Results Mab 3A5 specific for E.coli O157 and O113:H21 belonged to subtype IgM. The ascetic titers of the antibody was 1:1×106. No cross-reactivity of the Mab was observed with strains of Salmonella spp, Yersinia enterocolitica, Shigella dysenteriae, etc. The purified polyclonal antibody had a titer of 1:1×105 with E.coli O157. The detection limit of this sandwich ELISA was 103-104 cfu E.coli O157/mL in pure culture with a high specificity, which was characterized by every non-O157 strain with negative response. With 10h enrichment procedure, E.coli O157:H7 recovered well from inoculated ground poultry meat and pasteurized milk at levels of 0.1 cfu/g and 0.1 cfu/mL. Conclusion Mab 3A5 specific for E.coli O157 and O113:H21 can be produced by immunizing BALB/c mice with a strain of E.coli O157:H7. Then a sandwich ELISA can be developed with the polyclonal antibody as the capture antibody and the Mab 3A5 as the detection antibody. The method is proved to be a sensitive and specific technique to detect low number of E.coli O157 in food.

  9. AlGaN/GaN-based HEMT on SiC substrate for microwave characteristics using different passivation layers

    Indian Academy of Sciences (India)

    T R Lenka; A K Panda

    2012-07-01

    In this paper, a new gate-recessed AlGaN/GaN-based high electron mobility transistor (HEMT) on SiC substrate is proposed and its DC as well as microwave characteristics are discussed for Si3N4 and SiO2 passivation layers using technology computer aided design (TCAD). THe two-dimensional electron gas (2DEG) transport properties are discussed by solving Schödinger and Poison equations self-consistently resulting in various subbands having electron eigenvalues. From DC characteristics, the saturation drain currents are measured to be 600 mA/mm and 550 mA/mm for Si3N4 and SiO2 passivation layers respectively. Apart from DC, small-signal AC analysis has been done using two-port network for various microwwave parameters. The extrinsic transconductance parameters are measured to be 131.7 mS/mm at a gate voltage of $V_{gs} = -0.35$ V and 114.6 mS/mm at a gate voltage of $V_{gs} = -0.4$ V for Si3N4 and SiO2 passivation layers respectively. The current gain cut-off frequencies $(f_{t})$ are measured t be 27.1 GHz and 23.97 GHz in unit-gain-point method at a gate voltage of -0.4 V for Si3N4 and SiO2 passivation layers respectively. Similarly, the power gain cut-off frequencied $(f_{max})$ are measured to be 41 GHz and 38.5 GHz in unit-gain-point method at a gate voltage of -0.1 V for Si3N4 and SiO2 passivation layers respectively. Furthermore, the maximum frequency of oscillation or unit power gain (MUG = 1) cut-off frequencies for Si3N4 and SiO2 passivation layers are measured to be 32 GHz and 28 GHz respectively from MUG curves and the unit current gain, $|h_{21}| = 1$ cut-off frequencies are measured to be 140 GHz and 75 GHz for Si3N4 and SiO2 passivation layers respectively from the $abs |h_{21}|$ curves. HEMT with Si3N4 passivation layer giver better results than HEMT with SiO2 passivation layer.

  10. Crystal structures of four δ-keto esters and a Cambridge Structural Database analysis of cyano-halogen interactions.

    Science.gov (United States)

    Kamal, Kulsoom; Maurya, Hardesh K; Gupta, Atul; Vasudev, Prema G

    2015-10-01

    The revived interest in halogen bonding as a tool in pharmaceutical cocrystals and drug design has indicated that cyano-halogen interactions could play an important role. The crystal structures of four closely related δ-keto esters, which differ only in the substitution at a single C atom (by H, OMe, Cl and Br), are compared, namely ethyl 2-cyano-5-oxo-5-phenyl-3-(piperidin-1-yl)pent-2-enoate, C19H22N2O3, (1), ethyl 2-cyano-5-(4-methoxyphenyl)-5-oxo-3-(piperidin-1-yl)pent-2-enoate, C20H24N2O4, (2), ethyl 5-(4-chlorophenyl)-2-cyano-5-oxo-3-(piperidin-1-yl)pent-2-enoate, C19H21ClN2O3, (3), and the previously published ethyl 5-(4-bromophenyl)-2-cyano-5-oxo-3-(piperidin-1-yl)pent-2-enoate, C19H21BrN2O3, (4) [Maurya, Vasudev & Gupta (2013). RSC Adv. 3, 12955-12962]. The molecular conformations are very similar, while there are differences in the molecular assemblies. Intermolecular C-H...O hydrogen bonds are found to be the primary interactions in the crystal packing and are present in all four structures. The halogenated derivatives have additional aromatic-aromatic interactions and cyano-halogen interactions, further stabilizing the molecular packing. A database analysis of cyano-halogen interactions using the Cambridge Structural Database [CSD; Groom & Allen (2014). Angew. Chem. Int. Ed. 53, 662-671] revealed that about 13% of the organic molecular crystals containing both cyano and halogen groups have cyano-halogen interactions in their packing. Three geometric parameters for the C-X...N[triple-bond]C interaction (X = F, Cl, Br or I), viz. the N...X distance and the C-X...N and C-N...X angles, were analysed. The results indicate that all the short cyano-halogen contacts in the CSD can be classified as halogen bonds, which are directional noncovalent interactions.

  11. 墨西哥湾陆坡区冷泉碳酸盐岩的烷烃分布特征%Alkane distributions of seep-carbonates from the slopes of Gulf of Mexico

    Institute of Scientific and Technical Information of China (English)

    管红香; 陈多福; 冯东; 吴能友

    2009-01-01

    对墨西哥湾北部水深2 200m 的Alaminos Canyon 645区块(AC 645区)和水深540m的Green Canyon 185区块(GC 185区)冷泉碳酸盐岩的有机质进行了研究,结果显示深水和浅水区冷泉碳酸盐岩的有机质丰度和烷烃组成差别较大,下陆坡深水AC区样品有机质含量低,正构烷烃、萜烷、甾烷各组分的含量相对较高,正构烷烃以低碳数占绝对优势,并含有种类丰富的三环萜烷和五环三萜烷,且以17α(H),21β(H)-藿烷为主峰碳,反映了深水区冷泉碳酸盐岩的有机质来源于细菌和低等藻类,有少量的深部油气藏有机质的渗漏输入,并受微弱的微生物作用改造.上陆坡浅水GC区样品有机质含量较高,其中正构烷烃含量较低,并且以难以分开的复杂混合物(UCM)为主,同样含有种类丰富的以17α(H),21β(H)-降藿烷为主峰碳的三环萜烷和五环三萜烷,表明有机质主要来源于深部油气藏渗漏的有机质,并遭受了强烈的微生物降解.本文系统地研究了冷泉碳酸盐岩中正构烷烃、萜烷、甾烷的组成和分布特征,并探讨了有机质来源和冷泉渗漏的关系.

  12. Synthesis, crystal structure, interaction with BSA and antibacterial activity of La(III) and Sm(III) complexes with enrofloxacin.

    Science.gov (United States)

    Wang, Yan-Jun; Hu, Rui-Ding; Jiang, Dong-Hua; Zhang, Ping-Hua; Lin, Qiu-Yue; Wang, Yun-Yun

    2011-03-01

    Two new La(III) and Sm(III) complexes with enrofloxacin (HER, 1-cyclopropyl-7-(4-ethyl-1-piperazinyl)-6-fluoro-1,4-dihydro-4-oxo-3-quinoline carboxylic acid, C(19)H(21)FN(3)O(3)), [La(2)(ER)(6)(H(2)O)(2)]·14H(2)O(1) and [Sm(2)(ER)(6)(H(2)O)(2)]·14H(2)O(2) have been synthesized and characterized by elemental analysis, FT-IR, TG-DTG and X-ray single crystal diffraction. Both of the complexes are triclinic system with space group Pī. The structure of the complexes show that each rare earth atom in both complexes was nine-coordinated. Two of the enrofloxacin ions acted as tridentate chelate and bridging ligands, while the others as bidentate chelate ligands. The binding reaction between the complexes and bovine serum albumin (BSA) was studied by UV-vis absorption spectra and fluorescence spectroscopy. The results indicated that the two complexes had a quite strong ability to quench the fluorescence from BSA and the binding reaction was mainly a static quenching process. The binding constants K ( A )/(L·mol(-1)) were 1.46 × 10(5)(1) and 8.59 × 10(6)(2) and one binding site was formed. The synchronous spectroscopy suggested that tryptophan residues were placed in BSA. It was also found that the two complexes exhibited greater antimicrobial activity than enrofloxacin at given concentrations.

  13. Evaluation of biodiesel as bioremediation agent for the treatment of the shore affected by the heavy oil spill of the Prestige.

    Science.gov (United States)

    Fernández-Alvarez, P; Vila, J; Garrido, J M; Grifoll, M; Feijoo, G; Lema, J M

    2007-08-25

    The efficiency of different bioremediation products (nutrients, microorganisms and biodiesel) was tested using tiles located in both the supra-littoral and intertidal zones of a beach that was affected by the heavy oil spill of the Prestige. Neither nutrients nor microorganisms meant an improvement with respect to the natural processes. The addition of biodiesel improved the appearance of the treated tiles and apparently accelerated the degradation of the aliphatic and aromatic fractions of the residual fuel oil. Nevertheless, PAHs degradation was similar and very high in all the treatments (80-85% after 60 days). On the other hand, the evolution with time of the amount of vanadium was similar to that of 17alpha(H),21beta(H)-hopane, so it was concluded that vanadium could also be used to estimate the extent of oil degradation in the field. These results also suggested that the residual fuel oil mineralization was very low throughout 1 year in all the treatments. Moreover, the increase of the oxygen content of the residual oil from around 1% till 4-8% indicated that the partial oxidation of hydrocarbons took place, and that the hydrocarbon oxidation products accumulated in the polar fractions. In general, the results pointed out that bioremediation techniques were not suitable for the recovery of shores affected by heavy oil spills.

  14. Potential redox behaviour on industrial wastes treatment; Evolucion del potencial redox en tratamiento y depuracion industrial de aguas

    Energy Technology Data Exchange (ETDEWEB)

    Marin Galvin, R.; rodriguez Mellado, J. M.; Ruiz Montoya, M.; Jimenez Gamero, C. [Departamento Quimica Fisica y Termodinamica aplicada, Facultad de ciencias, Universidad de Cordoba (Spain)

    1995-12-31

    A study over the behaviour of redox potential in waters and wastewaters under industrial treatment processes has been carried out. In both cases, the potential-time curves obtained were in a logarithmical shape being more strongly distorted when the waters contained more dissolved and suspended compounds. Oxygen fundamentally leads the redox state in wastewaters, although ozone and chlorine almost oxygen lead the redox potential in raw waters intended to drinking water production. In this way, by increasing 210 m V the E{sub H} value of water or maintaining the rH>21.8 it can be industrially sterilized the drinking water. On the other hand, increases of 350 mV in the EH values from wastewaters influent to plant to the treated waters, allowed discarding 450 mg/l of DQO and 9 mg/l of NH{sub 3} from the former. Finally, the exploitation of the Wastewaters Treatment Plant by regulation of the E{sub H} values can suppose a good practice. (Author) 14 refs.

  15. Real Estate Taxes in Albania

    Directory of Open Access Journals (Sweden)

    Luciana Koprencka

    2013-04-01

    Full Text Available The construction sector is one of the mainsectors of the Albanian economy, which,during the last 20 years, has experiencedthe greatest economic growth. In 1991 thissector has contributed by 2.5% to the GDP,in 2006 by 4.9%, while in 2008, this sectorhas contributed by 14.9% to the national GDP. The relevant legislation has played animportant role in the development of this sector. The applied laws have tried to maintainat low levels the real estate prices and totransform such a problematic sector, withreference to fiscal evasion and informality,into an easily controllable sector. The taxesapplied in the construction sector are the sameas in other economic sectors, although thetaxation management in the construction sector, except forthose common principles thatregulate the tax management in general, isbased on some specificrules related to thecharacteristics of this sector. Increase the level of taxation on the transfer of ownership tothe extent of 10%, paralyzed the housing market by reducing the number of sales,especially of real estate old, previously this was 0.3-5%of sales value.JEL Classification: H21

  16. Drug: D10006 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available D10006 Drug Eplivanserin (USAN/INN) C19H21FN2O2 328.1587 328.3806 D10006.gif Treatm...tonin 5-HT2A-receptor [HSA:3356] [KO:K04157] Eplivanserin D10006 Eplivanserin (USAN/INN) CAS: 130579-75-8 Pu...bChem: 135626727 LigandBox: D10006 ATOM 24 1 C8x C 19.3200 -22.2600 2 C8x C 19.3200 -23.6600 3 C8x C 20.5100... -24.3600 4 C8x C 21.7700 -23.6600 5 C8y C 21.7700 -22.2600 6 C8y C 20.5100 -21.5...600 7 X F 22.9600 -21.5600 8 C2c C 20.5100 -20.1600 9 C2b C 19.3200 -19.4600 10 N2b N 21.7000 -19.4600 11 C2

  17. Limits on the Size and Orbit Distribution of Main Belt Comets

    CERN Document Server

    Sonnett, S; Jedicke, R; Masiero, J

    2011-01-01

    The seven known main belt comets (MBCs) have orbital characteristics of main belt asteroids yet exhibit dust ejection like comets. In order to constrain their physical and orbital properties we searched the Thousand Asteroid Light Curve Survey (TALCS; Masiero et al. 2009) for additional candidates using two diagnostics: tail and coma detection. This was the most sensitive MBC survey effort to date, extending the search from MBCs with H~18 (D~1 km) to H~21 (D~150 m). We fit each of the 924 TALCS objects to a PSF model incorporating both a coma and nuclear component to measure the fractional contribution of the coma to the total surface brightness. We determined the significance of the coma detection using the same algorithm on a sample of comparable null detections. We did not identify any MBC candidates with this technique to a sensitivity limit on the order of cometary mass loss rate of about 0.1 kg/s. Our tail detection algorithm identified statistically significant flux in a segmented annulus around the ca...

  18. Asteroid 2013 ND15: Trojan companion to Venus, PHA to the Earth

    CERN Document Server

    Marcos, C de la Fuente

    2014-01-01

    Venus has three known co-orbitals: (322756) 2001 CK32, 2002 VE68 and 2012 XE133. The first two have absolute magnitudes 18 < H < 21. The third one, significantly smaller at H = 23.4 mag, is a recent discovery that signals the probable presence of many other similar objects: small transient companions to Venus that are also potentially hazardous asteroids (PHAs). Here, we study the dynamical evolution of the recently discovered asteroid 2013 ND15. At H = 24.1 mag, this minor body is yet another small Venus co-orbital and PHA, currently close to the Lagrangian point L4 and following the most eccentric path found so far for objects in this group. Due to its high eccentricity (0.6), its dynamics is different from that of the other three known Venus co-orbitals even if they all are near-Earth objects (NEOs). A Monte Carlo simulation that uses the orbital data and discovery circumstances of the four objects as proxies to estimate the current size of this population, indicates that the number of high-eccentric...

  19. Effect of vacuum oxy-nitrocarburizing on the microstructure of tool steels: an experimental and modeling study

    Directory of Open Access Journals (Sweden)

    Nikolova Maria

    2017-01-01

    Full Text Available The thermochemical treatments of tool steels improve the performance of the components with respect to surface hardness, wear and tribological performance as well as corrosion resistance. Compared to the conventional gas ferritic nitrocarburizing process, the original vacuum oxy-nitrocarburizing is a time-, cost-effective and environmentally-friendly gas process. Because of the oxidizing nature of the gas atmosphere, there is no need to perform subsequent post-oxidation.In this study, a vacuum oxynitrocarburizing process was carried out onto four tool steels (AISI H10, H11, H21 and D2 at 570 °C, after hardening and single tempering. The structural analysis of the compound and diffusion layers was performed by optical and electron microscopy, X-ray diffraction and glow discharge optical emission spectrometry (GDOES methods. A largely monophase ε- layer is formed with a carbon accumulation at the substrate adjacent area. The overlaying oxides adjacent to the ε-carbonitride phase contained Fe3O4 (magnetite as a main constituent. A thermodynamic modelling approach was also performed to understand and optimize the process. The “Equilib module” of FactSage software which uses Gibbs energy minimization method, was used to estimate the possible products during vacuum oxynitrocarburising process.

  20. Involvement of the nervous system following experimental infection with Pasteurella multocida B:2 in buffalo (Bubalus bubalis): A clinicopathological study.

    Science.gov (United States)

    Marza, Ali Dhiaa; Jesse, Faez Firdaus Abdullah; Ahmed, Ihsan Muneer; Chung, Eric Lim Teik; Ibrahim, Hayder Hamzah; Zamri-Saad, Mohd; Omar, Abdul Rahman; Abu Bakar, Md Zuki; Saharee, Abdul Aziz; Haron, Abdul Wahid; Alwan, Mohammed Jwaid; Lila, Mohd Azmi Mohd

    2016-04-01

    Haemorrhagic septicaemia (HS) is an acute, fatal, septicaemic disease of cattle and buffaloes caused by one of two specific serotypes of Pasteurella multocida B:2 and E:2 in Asian and African, respectively. It is well known that HS affect mainly the respiratory and digestive tracts. However, involvement of the nervous system in pathogenesis of HS has been reported in previous studies without details. In this study, nine buffalo calves of 8 months old were distributed into three groups. Animals of Group 1 and 2 were inoculated orally and subcutaneously with 10 ml of 1 × 10(12) cfu/ml of P. multocida B:2, respectively, while animals of Group 3 were inoculated orally with 10 ml of phosphate buffer saline as a control. All calves in Group 1 and Group 3 were euthanised after 504 h (21 day) post-infection, while calves in Group 2 had to euthanise after 12 h post-infection as they develop sever clinical signs of HS. Significant differences were found in Group 2 in the mean scores of clinical signs, gross and histopathological changes which mainly affect different anatomic regions of the nervous system. In addition, successful bacterial isolation of P. multocida B:2 were obtained from different sites of the nervous system. On the other hand, less sever, clinical, gross and histopathological changes were found in Group 1. These results provide for the first time strong evidence of involving of the nervous system in pathogenesis of HS, especially in the peracute stage of the disease.

  1. Synthesis and Crystal Structure of N-tert-butyl-N′-(2,4-dichlorobenzoyl)-N-[1-(4-chlorophenyl)-1, 4-dihydro-6-methylpyridazine-4-oxo-3- carbonyl] hydrazine

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    The title compound N-tert-butyl-N¢-(2,4-dichlorobenzoyl)-N-[1-(4-chlorophenyl)- 1,4-dihydro-6-methylpyridazine-4-oxo-3-carbonyl]hydrazine [(C23H21N4O3Cl3)2·1.5H2O, Mr = 1042.60] was prepared by the reaction of 1-(4-chlorophenyl)-1,4-dihydro-4-oxo-6- methylpyridazine-3-carboxylic acid with chloroformate ethyl ester, then with N′-tert-butyl-N- (2,4-dichlorobenzoyl) hydrazine in the present of triethylamine. The crystal structure has been determined by X-ray diffraction. The crystal belongs to Monoclinic, space group P21/c, with unit cell constants a =11.4948(9), b=12.7495(10), c=35.854(3) ?, β =92.964(2)°, Z=4, V=5247.6(7) ?3, Dc = 1.320 Mg/m3, F(000) = 2156 , μ (MoKa)= 0.385, R = 0.0661, wR = 0.1875, for 9151 observed reflections( I >2σ(I)). The structure is a dimer linked by intermolecular hydrogen bond which can be observed between N(1)- H…O(6), N(5)- H…O(3). The distances are 2.068 and 2.027? respectively.

  2. Circadian rhythm of Z- and E-2-beta-D: -glucopyranosyloxy-4-methoxy cinnamic acids and herniarin in leaves of Matricaria chamomilla.

    Science.gov (United States)

    Repcák, Miroslav; Smajda, Benadik; Kovácik, Jozef; Eliasová, Adriana

    2009-07-01

    Chamomile (Matricaria chamomilla) in the above-ground organs synthesizes and accumulates (Z)- and (E)-2-beta-D: -glucopyranosyloxy-4-methoxy cinnamic acids (GMCA), the precursors of phytoanticipin herniarin (7-methoxycoumarin). The diurnal rhythmicity of the sum of GMCA (maximum before daybreak) and herniarin (acrophase at 10 h 21 min of circadian time) was observed under artificial lighting conditions LD 12:12. The acrophase is the time point of the maximum of the sinusoidal curve fitted to the experimental data. In continuous light, the circadian rhythms of both compounds were first described with similar acrophases of endogenous rhythms; a significantly different result from that in synchronized conditions. The rhythms' mesor (the mean value of the sinusoidal curve fitted to the experimental data) under free-running conditions was not influenced. Abiotic stress under synchronized conditions decreased the average content of GMCA to half of the original level and eliminated the rhythmicity. In contrast, the rhythm of herniarin continued, though its content significantly increased. Nitrogen deficiency resulted in a significant increase in GMCA content, which did not manifest any rhythmicity while the rhythm of herniarin continued. Circadian control of herniarin could be considered as a component of the plant's specialized defence mechanisms.

  3. Bohr effect of human hemoglobin A: magnitude of negative contributions determined by the equilibrium between two tertiary structures.

    Science.gov (United States)

    Okonjo, Kehinde O; Olatunde, Abimbola M; Fodeke, Adedayo A; Babalola, J Oyebamiji

    2014-06-01

    We have measured the affinity of the CysF9[93]β sulfhydryl group of human deoxyhemoglobin and oxyhemoglobin for 5,5'-dithiobis(2-nitrobenzoate), DTNB, between pH ≈5.6 and 9 in order to understand the basis of the reported reduction of the Bohr effect induced by chemical modification of the sulfhydryl. We analyzed the results quantitatively on the basis of published data indicating that the sulfhydryl exists in two conformations that are coupled to the transition between two tertiary structures of hemoglobin in dynamic equilibrium. Our analyses show that the ionizable groups linked to the DTNB reaction have lower pKas of ionization in deoxyhemoglobin compared to oxyhemoglobin. So these ionizable groups should make negative contributions to the Bohr effect. We identify these groups as HisNA2[2]β, HisEF1[77]β and HisH21[143]β. We provide explanations for the finding that hemoglobin, chemically modified at CysF9[93]β, has a lower Bohr effect and a higher oxygen affinity than unmodified hemoglobin.

  4. Virulence profiles of Shiga toxin-producing Escherichia coli and other potentially diarrheagenic E.coli of bovine origin, in Mendoza, Argentina

    Directory of Open Access Journals (Sweden)

    M.A. Pizarro

    2013-12-01

    Full Text Available This study described a group of strains obtained from a slaughter house in Mendoza, in terms of their pathogenic factors, serotype, antibiotype and molecular profile. Ninety one rectal swabs and one hundred eight plating samples taken from carcasses of healthy cattle intended for meat consumption were analyzed. Both the swab and the plate samples were processed to analyze the samples for the presence of virulence genes by PCR: stx1, stx2, eae and astA. The Stx positive strains were confirmed by citotoxicity assay in Vero cells. The isolates were subsequently investigated for their O:H serotype, antimicrobial susceptibility and molecular profile by Random Amplification of Polymorphic DNA (RAPD. Twelve E.coli strains were identified by their pathogenicity. Nine were from fecal origin and three from carcasses. Three strains carried the stx1 gene, three the stx2 gene, two carried eae and four the astA gene. The detected serotypes were: O172:H-; O150:H8; O91:H21; O178:H19 and O2:H5. The strains showed a similarity around 70% by RAPD. Some of the E.coli strains belonged to serogroups known for certain life-threatening diseases in humans. Their presence in carcasses indicates the high probability of bacterial spread during slaughter and processing.

  5. Acute effects of nicotine and mecamylamine on tobacco withdrawal symptoms, cigarette reward and ad lib smoking.

    Science.gov (United States)

    Rose, J E; Behm, F M; Westman, E C

    2001-02-01

    Separate and combined effects of nicotine and the nicotinic antagonist mecamylamine were studied in 32 healthy volunteer smokers after overnight abstinence from smoking. Subjects participated in three sessions (3 h each), during which they wore skin patches delivering either 0 mg/24 h, 21 mg/24 h or 42 mg/24 h nicotine. Thirty-two subjects were randomly assigned to two groups receiving oral mecamylamine hydrochloride (10 mg) vs. placebo capsules. Two and one-half hours after drug administration, subjects were allowed to smoke ad lib, rating the cigarettes for rewarding and aversive effects. Transdermal nicotine produced a dose-related reduction in the subjective rewarding qualities of smoking. Nicotine also reduced craving for cigarettes and this effect was attenuated, but not eliminated, by mecamylamine. Mecamylamine blocked the discriminability of high vs. low nicotine puffs of smoke, and increased nicotine intake substantially during the ad lib smoking period. Some of the psychophysiological effects of each drug (elevation in blood pressure from nicotine, sedation and decreased blood pressure from mecamylamine) were offset by the other drug. The results supported the hypothesis that nicotine replacement can alleviate tobacco withdrawal symptoms even in the presence of an antagonist such as mecamylamine. Mecamylamine did not precipitate withdrawal beyond the level associated with overnight cigarette deprivation, suggesting its effects were primarily due to offsetting the action of concurrently administered nicotine as opposed to blocking endogenous cholinergic transmission.

  6. X-Ray Transient in Musca (GRS 1121-68 = GS 1124-683)

    DEFF Research Database (Denmark)

    Lund, Niels; Brandt, Søren; Makino, F.

    1991-01-01

    Research Institute, Lyngby; and Space Research Institute, Moscow), report: "A new x-ray source in Musca, GRS 1121-68, has been discovered in data obtained by the WATCH detectors on Jan. 9. The spectrum of the source was harder than that of the Crab nebula, and the flux was about twice that from...... the Crab and increasing slowly during the observation. The source remained at a constant intensity level on Jan. 10. On Jan. 5 this source was not bright enough to be detectable by WATCH. The preliminary position is R.A. = 11h21m, Decl. = -68.1 deg (equinox 1950.0; uncertainty about 1 deg). We have...... not found any catalogued hard x-ray sources within our error circle; however, close to the given position, we have noted the existence of a radio pulsar (at R.A. = 11h10m, Decl. = -69 deg) with a period of 0.8 s, and a gamma-ray burst source, GRB 820829B, detected by Venera 13/14 in 1982. We have...

  7. High resolution mapping of Dense spike-ar (dsp.ar) to the genetic centromere of barley chromosome 7H.

    Science.gov (United States)

    Shahinnia, Fahimeh; Druka, Arnis; Franckowiak, Jerome; Morgante, Michele; Waugh, Robbie; Stein, Nils

    2012-02-01

    Spike density in barley is under the control of several major genes, as documented previously by genetic analysis of a number of morphological mutants. One such class of mutants affects the rachis internode length leading to dense or compact spikes and the underlying genes were designated dense spike (dsp). We previously delimited two introgressed genomic segments on chromosome 3H (21 SNP loci, 35.5 cM) and 7H (17 SNP loci, 20.34 cM) in BW265, a BC(7)F(3) nearly isogenic line (NIL) of cv. Bowman as potentially containing the dense spike mutant locus dsp.ar, by genotyping 1,536 single nucleotide polymorphism (SNP) markers in both BW265 and its recurrent parent. Here, the gene was allocated by high-resolution bi-parental mapping to a 0.37 cM interval between markers SC57808 (Hv_SPL14)-CAPSK06413 residing on the short and long arm at the genetic centromere of chromosome 7H, respectively. This region putatively contains more than 800 genes as deduced by comparison with the collinear regions of barley, rice, sorghum and Brachypodium, Classical map-based isolation of the gene dsp.ar thus will be complicated due to the infavorable relationship of genetic to physical distances at the target locus.

  8. catena-Poly[2,2′,2′′-nitrilotris(ethanaminium [tri-μ-oxido-tris[dioxidovanadate(V

    Directory of Open Access Journals (Sweden)

    Kelvin B. Chang

    2013-11-01

    Full Text Available The title compound, {(C6H21N4[V3O9]·H2O}n, crystallizes as a salt with [trenH3]3+ cations [tren is tris(2-aminoethylamine], and one-dimensional anionic {[VVO3]−}n (metavanadate chains along the c-axis direction. Three crystallographically distinct VV sites and one occluded water molecule are present for every [trenH3]3+ cation in the unit cell. The {[VVO3]−}n chains are composed of vertex-sharing [VO4] tetrahedra and have a repeat unit of six tetrahedra. Each tetrahedron in the chain contains two terminal and two μ2-bridging oxide ligands. The [trenH3]3+ cations, {[VVO3]−}n anions and occluded water molecules participate in an extensive three-dimensonal hydrogen-bonding network. The three terminal ammonium sites of the [trenH3]3+ cations each form strong N—H...O hydrogen bonds to terminal oxide ligands on the {[VVO3]−}n chain. Each occluded water molecule also donates two O—H...O hydrogen bonds to the terminal oxide ligands.

  9. Three closely related dibenzazepine carboxylic acids: hydrogen-bonded aggregation in one, two and three dimensions.

    Science.gov (United States)

    Sanabría, Carlos M; Palma, Alirio; Cobo, Justo; Glidewell, Christopher

    2014-03-01

    In the structure of (6R*,11R*)-5-acetyl-11-ethyl-6,11-dihydro-5H-dibenzo[b,e]azepine-6-carboxylic acid, C19H19NO3, (I), the molecules are linked into sheets by a combination of O-H...O and C-H...O hydrogen bonds; in the structure of the monomethyl analogue (6RS,11SR)-5-acetyl-11-ethyl-2-methyl-6,11-dihydro-5H-dibenzo[b,e]azepine-6-carboxylic acid, C20H21NO3, (II), the molecules are linked into simple C(7) chains by O-H...O hydrogen bonds; and in the structure of the dimethyl analogue (6RS,11SR)-5-acetyl-11-ethyl-1,3-dimethyl-6,11-dihydro-5H-dibenzo[b,e]azepine-6-carboxylic acid, C21H23NO3, (III), a combination of O-H...O, C-H...O and C-H...π(arene) hydrogen bonds links the molecules into a three-dimensional framework structure. None of these structures exhibits the R2(2)(8) dimer motif characteristic of simple carboxylic acids.

  10. Biological marker distribution in coexisting kerogen, bitumen and asphaltenes in Monterey Formation diatomite, California

    Energy Technology Data Exchange (ETDEWEB)

    Tannenbaum, E.; Ruth, E.; Huizinga, B.J.; Kaplan, I.R.

    1986-01-01

    Organic-rich (18.2%) Monterey Formation diatomite from California was studied. The organic matter consist of 94% bitumen and 6% kerogen. Biological markers from the bitumen and from pyrolysates of the coexisting asphaltenes and kerogen were analyzed in order to elucidate the relationship between the various fractions of the organic matter. While 17..cap alpha.. (H), 18..cap alpha.. (H), 21..cap alpha.. (H)-28,30-bisnorhopane was present in the bitumen and in the pyrolysate of the asphaltenes, it was not detected in the pyrolysates of the kerogen. A C/sub 40/-isoprenoid with head to head linkage, however, was present in pyrolysates of both kerogen and asphaltenes, but not in the bitumen from the diatomite. The maturation level of the bitumen, based on the extent of isomerization of steranes and hopanes, was that of a mature oil, whereas the pyrolysate from the kerogen showed a considerably lower maturation level. These relationships indicate that the bitumen may not be indigenous to the diatomite and that it is a mature oil that migrated into the rock. They consider the possibility, however, that some of the 28,30-bisnorhopane-rich Monterey Formation oils have not been generated through thermal degradation of kerogen, but have been expelled from the source rock at an early stage of diagenesis.

  11. Crystal structures of (E-3-(furan-2-yl-2-phenyl-N-tosylacrylamide and (E-3-phenyl-2-(m-tolyl-N-tosylacrylamide

    Directory of Open Access Journals (Sweden)

    Dong Cheng

    2016-06-01

    Full Text Available In the title N-tosylacrylamide compounds, C20H17NO4S, (I, and C23H21NO3S, (II, the conformation about the C=C bond is E. The acrylamide groups, [–NH—C(=O—C=C–], are almost planar, with the N—C—C=C torsion angle being −170.18 (14° in (I and −168.01 (17° in (II. In (I, the furan, phenyl and 4-methylbenzene rings are inclined to the acrylamide mean plane by 26.47 (11, 69.01 (8 and 82.49 (9°, respectively. In (II, the phenyl, 3-methylbenzene and 4-methylbenzene rings are inclined to the acrylamide mean plane by 11.61 (10, 78.44 (10 and 78.24 (10°, respectively. There is an intramolecular C—H...π interaction present in compound (II. In the crystals of both compounds, molecules are linked by pairs of N—H...O hydrogen bonds, forming inversion dimers with an R22(8 ring motif. In (I, the dimers are reinforced by C—H...O hydrogen bonds and linked by C—H...π interactions, forming chains along [011]. In the crystal of (II, the dimers are linked via C—H...O hydrogen bonds, forming chains along [100]. The chains are further linked by C—H...π interactions, forming layers parallel to (010.

  12. Determination of arterial wall shear stress

    Institute of Scientific and Technical Information of China (English)

    LIU; Zhaorong

    2001-01-01

    [1]Langille, B. L., 7Donnell, F., Reductions in arterial diameter produced by chronic decreases in blood flow are endothelium-dependent, Science, 1986, 231: 405—407.[2]Langer, R., Vacanti, J. P., Tissue engineering, Science, 1993, 260: 920—926.[3]Kamiya, A., Togawa, T., Adaptive regulation of wall shear stress to flow change in the canine carotid artery, Am. J. Physiol. (Heart Circ. Physiol.), 1980, 239: H14—H21.[4]Fung, Y. C., Biomechanics: Motion, Flow, Stress, and Growth, New York: Springer-Verlag, 1990.[5]Liu, S. Q., Biomechanical basis of vascular tissue engineering, Critical Reviews in Biomedical Engineering, 1999, 27: 75—148.[6]Ando, J., Kamiya, A., Blood flow and vascular endothelium cell function, Frontiers Med. Biological Eng., 1993, 5: 245—264.[7]Ku, D. N., Giddens, D. P., Zarins, D. K. et al., Pulsatile flow and atherosclerosis in the human carotid bifurcation-positive correlation between plaque location and low and oscillating shear stress, Atherosclerosis, 1985, 5: 293—302.[8]Liu Zhaorong, Li Xixi, Theory and Method on Hemodynamics (in Chinese), Shanghai: Fudan University Press, 1997.

  13. Physical entropy, information entropy and their evolution equations

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    [1]Langille, B. L., 7Donnell, F., Reductions in arterial diameter produced by chronic decreases in blood flow are endothelium-dependent, Science, 1986, 231: 405—407.[2]Langer, R., Vacanti, J. P., Tissue engineering, Science, 1993, 260: 920—926.[3]Kamiya, A., Togawa, T., Adaptive regulation of wall shear stress to flow change in the canine carotid artery, Am. J. Physiol. (Heart Circ. Physiol.), 1980, 239: H14—H21.[4]Fung, Y. C., Biomechanics: Motion, Flow, Stress, and Growth, New York: Springer-Verlag, 1990.[5]Liu, S. Q., Biomechanical basis of vascular tissue engineering, Critical Reviews in Biomedical Engineering, 1999, 27: 75—148.[6]Ando, J., Kamiya, A., Blood flow and vascular endothelium cell function, Frontiers Med. Biological Eng., 1993, 5: 245—264.[7]Ku, D. N., Giddens, D. P., Zarins, D. K. et al., Pulsatile flow and atherosclerosis in the human carotid bifurcation-positive correlation between plaque location and low and oscillating shear stress, Atherosclerosis, 1985, 5: 293—302.[8]Liu Zhaorong, Li Xixi, Theory and Method on Hemodynamics (in Chinese), Shanghai: Fudan University Press, 1997.

  14. Construction of many-particle spin entangled states and signature

    Institute of Scientific and Technical Information of China (English)

    ZHU; Hongbo

    2001-01-01

    [1]Langille, B. L., 7Donnell, F., Reductions in arterial diameter produced by chronic decreases in blood flow are endothelium-dependent, Science, 1986, 231: 405—407.[2]Langer, R., Vacanti, J. P., Tissue engineering, Science, 1993, 260: 920—926.[3]Kamiya, A., Togawa, T., Adaptive regulation of wall shear stress to flow change in the canine carotid artery, Am. J. Physiol. (Heart Circ. Physiol.), 1980, 239: H14—H21.[4]Fung, Y. C., Biomechanics: Motion, Flow, Stress, and Growth, New York: Springer-Verlag, 1990.[5]Liu, S. Q., Biomechanical basis of vascular tissue engineering, Critical Reviews in Biomedical Engineering, 1999, 27: 75—148.[6]Ando, J., Kamiya, A., Blood flow and vascular endothelium cell function, Frontiers Med. Biological Eng., 1993, 5: 245—264.[7]Ku, D. N., Giddens, D. P., Zarins, D. K. et al., Pulsatile flow and atherosclerosis in the human carotid bifurcation-positive correlation between plaque location and low and oscillating shear stress, Atherosclerosis, 1985, 5: 293—302.[8]Liu Zhaorong, Li Xixi, Theory and Method on Hemodynamics (in Chinese), Shanghai: Fudan University Press, 1997.

  15. Crystal structure of 1-[2-(4-nitro-phen-yl)-4,5-diphenyl-1H-imidazol-1-yl]propan-2-ol.

    Science.gov (United States)

    Simpson, Jim; Mohamed, Shaaban K; Marzouk, Adel A; Abdelhamid, Antar A; Albayati, Mustafa R

    2017-09-01

    The title compound, C24H21N3O3, crystallizes with two unique but closely r.m.s. overlay fit = 0.215 Å) comparable mol-ecules (1 and 2) in the asymmetric unit of the triclinic unit cell. In molecule 1, the dihedral angles between the central imidazlole ring and the benzene-ring substituents are 42.51 (9), 45.41 (9) and 56.92 (8)°, respectively. Comparable data for molecule 2 are 39.36 (10), 34.45 (11) and 60.34 (8)°, respectively. The rings at the 2-positions carry p-nitro substituents that subtend dihedral angles of 12.9 (4)° in mol-ecule 1 and 11.7 (4)° in mol-ecule 2 to their respective benzene ring planes. The imidazole rings also have propan-2-ol substituents on the 1-N atoms, which adopt extended conformations for the N-C-C-C chains. In the crystal, classical O-H⋯N hydrogen bonds combine with C-H⋯O, C-H⋯N and C-H⋯π(ring) hydrogen bonds and stack the molecules along the a-axis direction.

  16. Crystal structure of (4-methoxyphenyl[(4-methoxyphenylphosphonato]dioxidophosphate(1− 2-amino-6-benzyl-3-ethoxycarbonyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-6-ium

    Directory of Open Access Journals (Sweden)

    Joel T. Mague

    2015-12-01

    Full Text Available The asymmetric unit of the title molecular salt, C17H21N2O2S+·C14H15O7P2−, comprises two cations and two anions. Each cation features an intramolecular N—H...O hydrogen bond, which closes an S(6 ring; in each case the hydropyridine ring adopts a half-chair conformation. In the anions, the dihedral angles between the aromatic rings are 64.1 (2 and 54.9 (2°. In each case, the diphosphate groups are close to eclipsed [C—P...P—C pseudo-torsion angles = 11.6 (2 and −19.3 (2°]. One of the methoxy groups in each anion is disordered over two orientations in a 0.539 (18:0.461 (18 ratio in one anion and 0.82 (2:0.18 (2 in the other. In the crystal, O—H...O and N—H...O hydrogen bonds link the components into [100] chains. Numerous C—H...O interactions cross-link the chains into a three-dimensional network.

  17. [μ-Bis(diphenylarsinomethane-1:2κ2As:As′]nonacarbonyl-1κ3C,2κ3C,3κ3C-[tris(4-methylphenylphosphine-3κP]-triangulo-triruthenium(0

    Directory of Open Access Journals (Sweden)

    Omar bin Shawkataly

    2010-01-01

    Full Text Available In the title triangulo-triruthenium compound, [Ru3(C25H22As2(C21H21P(CO9], the bis(diphenylarsinomethane ligand bridges a Ru—Ru bond and the monodentate phosphine ligand bonds to the third Ru atom. Both the phosphine and arsine ligands are equatorial with respect to the Ru3 triangle. Additionally, each Ru atom carries one equatorial and two axial terminal carbonyl ligands. The three phenyl rings of the phosphine make dihedral angles of 86.89 (19, 82.1 (2 and 63.0 (2° with each other. The dihedral angles between the two phenyl rings are 73.8 (2 and 82.2 (3° for the two diphenylarsino groups. An intramolecular C—H...O hydrogen bond stabilizes the molecular structure. In the crystal packing, molecules are linked into chains down the b axis via intermolecular C—H...O hydrogen bonds.

  18. Detection of Shiga toxin-producing Escherichia coli in meat marketed in Casablanca (Morocco).

    Science.gov (United States)

    Badri, S; Fassouane, A; Filliol, I; Hassar, M; Cohen, N

    2011-03-01

    The contamination of meat and meat products with Shiga toxin-producing O157:H7 and non-O157 Escherichia coli (STEC), obtained from markets in Casablanca, Morocco, was investigated. A total of 460 meat and meat products were sampled between March 2004 and July 2006 analysed and 176 strains of E. coli were isolated from these samples. The presence of the stx1, stx2, eae and ehxA genes, recognized as major virulence factors of STEC, was tested in E. coli isolates by polymerase chain reaction (PCR). STEC was detected in 4 (0.9%) samples. The result of serotyping by molecular method showed that two of these STEC isolates corresponded to the serotype O157:H7. The others Shiga toxin-producing E. coli non-O157 corresponded to O6:H21 and O76:H19. The presence of O157:H7 and non-O157 STEC in meat and meat products marketed in Casablanca, Morocco, emphasizes the importance of implementing the Hazard Analysis and Critical Control Point (HACCP) system, as well as the need for implementing, evaluating, and validating antimicrobial interventions to reduce the presence of potential pathogenic microorganisms.

  19. [Survival of VTEC O157 and non-O157 in water troughs and bovine feces].

    Science.gov (United States)

    Polifroni, Rosana; Etcheverría, Analía I; Arroyo, Guillermo H; Padola, Nora L

    2014-01-01

    Verotoxin-producing Escherichia coli (VTEC) is the etiologic agent of hemolytic-uremic syndrome (HUS), which typically affects children ranging in age from six months to five years old. Transmission is produced by consumption of contaminated food, by direct contact with animals or the environment and from person to person. In previous studies we determined that the environment of a dairy farm is a non-animal reservoir; thus, we proposed to study the survival of 4 VTEC isolates (O20:H19; O91:H21; O157:H7 and O178:H19) in sterile water troughs and bovine feces by viable bacteria count and detection of virulence genes by PCR. It was demonstrated that the survival of different VTEC isolates (O157 and non-O157) varied in terms of their own characteristics as well as of the environmental conditions where they were found. The main differences between isolates were their survival time and the maximal counts reached. The competitive and adaptive characteristics of some isolates increase the infection risk for people that are visiting or working on a farm, as well as the risk for reinfection of the animals and food contamination. Copyright © 2014 Asociación Colombiana de Psiquiatría. Publicado por Elsevier España. All rights reserved.

  20. THE IDENTIFICATION OF THE X-RAY COUNTERPART TO PSR J2021+4026

    Energy Technology Data Exchange (ETDEWEB)

    Weisskopf, Martin C.; Elsner, Ronald F.; O' Dell, Stephen L.; Tennant, Allyn F. [NASA Marshall Space Flight Center, Space Science Office, VP62, Huntsville, AL 35812 (United States); Romani, Roger W. [Department of Physics, Stanford University, Stanford, CA 94305 (United States); Razzano, Massimiliano [Istituto Nazionale di Fisica Nucleare, Sezione di Pisa, I-56127 Pisa (Italy); Belfiore, Andrea; Saz Parkinson, Pablo; Ziegler, Marcus; Dormody, Michael [Santa Cruz Institute for Particle Physics, Department of Physics, University of California at Santa Cruz, Santa Cruz, CA 95064 (United States); Ray, Paul S. [Space Science Division, Naval Research Laboratory, Washington, DC 20375 (United States); Kerr, Matthew [Kavli Institute for Particle Astrophysics and Cosmology, Stanford University, 452 Lomita Mall, Stanford, CA 94305 (United States); Harding, Alice [Astrophysics Science Division, NASA Goddard Space Flight Center, Code 663, Greenbelt, MD 20771 (United States); Swartz, Douglas A. [Universities Space Research Association, NASA Marshall Space Flight Center, Space Science Office, VP62, Huntsville, AL 35812 (United States); Carraminana, Alberto [Instituto Nacional de Astrofisica, Optica y Electronica, Luis Enrique Erro 1, Tonantzintla, Puebla 72840 (Mexico); Becker, Werner; Kanbach, Gottfried [Max-Planck-Institut fuer extraterrestrische Physik, 85741 Garching bei Muenchen (Germany); De Luca, Andrea [INAF-Istituto di Astrofisica Spaziale e Fisica Cosmica, I-20133 Milano (Italy); Thompson, David J. [Astroparticle Physics Laboratory, NASA Goddard Space Flight Center, Code 661, Greenbelt, MD 20771 (United States)

    2011-12-10

    We report the probable identification of the X-ray counterpart to the {gamma}-ray pulsar PSR J2021+4026 using imaging with the Chandra X-ray Observatory Advanced CCD Imaging Spectrometer and timing analysis with the Fermi satellite. Given the statistical and systematic errors, the positions determined by both satellites are coincident. The X-ray source position is R.A. 20{sup h}21{sup m}30.{sup s}733, decl. +40 Degree-Sign 26'46.''04 (J2000) with an estimated uncertainty of 1.''3 combined statistical and systematic error. Moreover, both the X-ray to {gamma}-ray and the X-ray to optical flux ratios are sensible assuming a neutron star origin for the X-ray flux. The X-ray source has no cataloged infrared-to-visible counterpart and, through new observations, we set upper limits to its optical emission of i' > 23.0 mag and r' > 25.2 mag. The source exhibits an X-ray spectrum with most likely both a power law and a thermal component. We also report on the X-ray and visible light properties of the 43 other sources detected in our Chandra observation.

  1. Development of superconducting crossbar-H-mode cavities for proton and ion accelerators

    Directory of Open Access Journals (Sweden)

    F. Dziuba

    2010-04-01

    Full Text Available The crossbar-H-mode (CH structure is the first superconducting multicell drift tube cavity for the low and medium energy range operated in the H_{21} mode. Because of the large energy gain per cavity, which leads to high real estate gradients, it is an excellent candidate for the efficient acceleration in high power proton and ion accelerators with fixed velocity profile. A prototype cavity has been developed and tested successfully with a gradient of 7  MV/m. A few new superconducting CH cavities with improved geometries for different high power applications are under development at present. One cavity (f=325  MHz, β=0.16, seven cells is currently under construction and studied with respect to a possible upgrade option for the GSI UNILAC. Another cavity (f=217  MHz, β=0.059, 15 cells is designed for a cw operated energy variable heavy ion linac application. Furthermore, the EUROTRANS project (European research program for the transmutation of high level nuclear waste in an accelerator driven system, 600 MeV protons, 352 MHz is one of many possible applications for this kind of superconducting rf cavity. In this context a layout of the 17 MeV EUROTRANS injector containing four superconducting CH cavities was proposed by the Institute for Applied Physics (IAP Frankfurt. The status of the cavity development related to the EUROTRANS injector is presented.

  2. Seasonal rates of benthic primary production in a Greenland fjord measured by aquatic eddy correlation

    DEFF Research Database (Denmark)

    M. Attard, Karl; Glud, Ronnie; McGinnis, Daniel F.

    2014-01-01

    We present the first year-round estimates of benthic primary production at four contrasting shallow (3–22 m depth) benthic habitats in a southwest Greenland fjord. In situ measurements were performed using the noninvasive aquatic eddy-correlation (EC) oxygen (O2) flux method. A series of high......-quality multiple-day EC data sets document the presence of a year-round productive benthic phototrophic community. The shallow-water sites were on average autotrophic during the spring and summer months, up to 43.6 mmol O2 m22 d21, and heterotrophic or close to metabolic balance during the autumn and winter....... Substantial benthic gross primary production (GPP) was measured year-round. The highest GPP rates were measured during the spring, up to 5.7 mmol O2 m22 h21 (136.8 mmol O2 m22 d21), and even at low light levels (, 80 mmol quanta m22 s21) during late autumn and winter we measured rates of up to 1.8 mmol O2 m22...

  3. Diurnal fluctuations of cocaine and potential precursors in leaves of Erythroxylum coca.

    Science.gov (United States)

    Johnson, E L

    1993-01-01

    Cocaine is abundant in leaves of Erythroxylum coca var. coca Lam. Consequently, cocaine and two of its early biosynthetic precursors were monitored for 24 h to determine whether they fluctuated diurnally. E. coca was grown under controlled environmental conditions in a growth chamber in soil at pH 3.5. After 17.5 months of growth, leaves not less than 35 days old were harvested every 2 and 4 h for 24 h for arginine, phenylalanine and cocaine content, respectively. The content of cocaine was determined by GC/MS and amino acid content by HPLC. Diurnal fluctuation of cocaine occurred during the 24 h cycle. Cocaine was highest in leaves of E. coca at 8 and 16 h where its content was 7.67 and 9.45 mg.g-1 dry weight, respectively. Arginine and phenylalanine in leaves of E. coca also displayed diurnal rhythmic patterns of fluctuation. The content of arginine declined from hours 6 to 12 and increased to the highest content at 13 h (21.8 mg.g-1 dry weight). Overall, phenylalanine content was lower than arginine, but had two peak periods of accumulation during the 24 h cycle, occurring at 8 and 14 h. The content of phenylalanine in leaves of E. coca during the peak hours was 6.98 and 6.54 mg.g-1 dry weight, respectively.

  4. Hydrocarbon geochemistry of the Puget Sound region. II. Sedimentary diterpenoid, steroid and triterpenoid hydrocarbons

    Energy Technology Data Exchange (ETDEWEB)

    Barrick, R.C.; Hedges, J.I.

    1981-03-01

    Cyclic components of the aliphatic hydrocarbon mixtures extracted from Puget Sound sediment cores include a suite of C/sub 19/ and C/sub 20/ diterpenoid hydrocarbons of which fichtelite, sandaracopimaradiene, and isopimaradiene have been identified. Although apparently also derived from vascular plants, these diterpenoid hydrocarbons have relative abundances distinctly different from the co-existing plant wax n-alkane suite. Five C/sub 27/, C/sub 28/ and C/sub 29/ diasteranes and four C/sub 29/, C/sub 30/ and C/sub 31/ 17..cap alpha..(H), 21..beta..(H) hopanes occur in relatively constant proportion as components of a highly weathered fossil hydrocarbon assemblage. These chromatographically resolved cycloalkanes, along with the strongly covarying unresolved complex mixture, have been introduced to Puget Sound sediments from adjacent urban centres at increasing levels over the last 100 yr in the absence of any major oil spill. Naturally-occurring triterpenoid hydrocarbons, including hop-22(29)-ene (diploptene), are also present. A new group of C/sub 30/ polyenes has been detected which contains compounds apparently structurally related to a co-existing bicyclic C/sub 25/ diene and to C/sub 20/ and C/sub 25/ acyclic multibranched hydrocarbons described in a previous paper (Barrick et al., 1980).

  5. Hydrocarbon geochemistry of the Puget Sound region - II. Sedimentary diterpenoid, steroid and triterpenoid hydrocarbons

    Science.gov (United States)

    Barrick, Robert C.; Hedges, John I.

    1981-03-01

    Cyclic components of the 'aliphatic' hydrocarbon mixtures extracted from Puget Sound sediment cores include a suite of C 19 and C 20 diterpenoid hydrocarbons of which fichtelite. sandaracopimaradiene, and isopimaradiene have been identified. Although apparently also derived from vascular plants, these diterpenoid hydrocarbons have relative abundances distinctly different from the co-existing plant wax n-alkane suite. Five C 27, C 28 and C 29 diasteranes and four C 29, C 30 and C 31 17α(H), 21β(H) hopanes occur in relatively constant proportion as components of a highly weathered fossil hydrocarbon assemblage. These chromatographically resolved cycloalkanes. along with the strongly covarying unresolved complex mixture, have been introduced to Puget Sound sediments from adjacent urban centres at increasing levels over the last 100 yr in the absence of any major oil spill. Naturally-occurring triterpenoid hydrocarbons, including hop-22(29)-ene (diploptene), are also present. A new group of C 30 polyenes has been detected which contains compounds apparently structurally related to a co-existing bicyclic C 25 diene and to C 20 and C 25 acyclic multibranched hydrocarbons described in a previous paper ( BARRICK et al., 1980).

  6. The Multiwavelength Survey by Yale-Chile (MUSYC): Deep Near-Infrared Imaging and the Selection of Distant Galaxies

    CERN Document Server

    Quadri, R; van Dokkum, P; Gawiser, E; Franx, M; Lira, P; Rudnick, G; Urry, C M; Maza, J; Kriek, M; Barrientos, L F; Blanc, G; Castander, F J; Christlein, D; Coppi, P S; Hall, P B; Herrera, D; Infante, L; Taylor, E N; Treister, E; Willis, J P; Quadri, Ryan; Marchesini, Danilo; Dokkum, Pieter van; Gawiser, Eric; Franx, Marijn; Lira, Paulina; Rudnick, Gregory; Maza, Jose; Kriek, Mariska; Blanc, Guillermo; Castander, Francisco J.; Christlein, Daniel; Coppi, Paolo S.; Hall, Patrick B.; Herrera, David; Infante, Leopoldo; Taylor, Edward N.; Treister, Ezequiel; Willis, Jon P.

    2006-01-01

    We present deep near-infrared JHK imaging of four 10'x10' fields. The observations were carried out as part of the Multiwavelength Survey by Yale-Chile (MUSYC) with ISPI on the CTIO 4m telescope. The typical point source limiting depths are J~22.5, H~21.5, and K~21 (5sigma; Vega). The effective seeing in the final images is ~1.0". We combine these data with MUSYC UBVRIz imaging to create K-selected catalogs that are unique for their uniform size, depth, filter coverage, and image quality. We investigate the rest-frame optical colors and photometric redshifts of galaxies that are selected using common color selection techniques, including distant red galaxies (DRGs), star-forming and passive BzKs, and the rest-frame UV-selected BM, BX, and Lyman break galaxies (LBGs). These techniques are effective at isolating large samples of high redshift galaxies, but none provide complete or uniform samples across the targeted redshift ranges. The DRG and BM/BX/LBG criteria identify populations of red and blue galaxies, r...

  7. A Comparative X-ray Diffraction Study and Ab Initio Calculation on RU60358, a New Pyrethroid

    Directory of Open Access Journals (Sweden)

    Gérard Vergoten

    2006-08-01

    Full Text Available The crystal structure of RU60358, C20H21NO3, has been determined using X-raydiffraction to establish the configuration and stereochemistry of the molecule around theC15-C16 triple bond. The compound crystallises in the orthorhombic space group P212121, a= 7.7575, b = 11.3182, c = 21.3529å, V = 1874.80å3 and Z = 4. The structure has beenrefined to a final R = 0.068 for the observed structure factors with I ≥ 3σ (I. The refinedstructure was found to be significantly non planar. A comparative study, using the ab initiocalculations of the structure at B3LYP/6-31G** levels of theory, shows good geometricalagreement with the X-ray diffraction data. Standard deviations between the calculated andexperimental bond values have been shown to be 0.01 å and 0.5° for bond angles.Vibrational wavenumbers were obtained from a normal mode analysis using the ab initiocalculations.

  8. Biological marker distribution in coexisting kerogen, bitumen and asphaltenes in Monterey Formation diatomite, California

    Science.gov (United States)

    Tannenbaum, E.; Ruth, E.; Huizinga, B. J.; Kaplan, I. R.

    1986-01-01

    Organic-rich (18.2%) Monterey Formation diatomite from California was studied. The organic matter consist of 94% bitumen and 6% kerogen. Biological markers from the bitumen and from pyrolysates of the coexisting asphaltenes and kerogen were analyzed in order to elucidate the relationship between the various fractions of the organic matter. While 17 alpha(H), 18 alpha(H), 21 alpha(H)-28,30-bisnorhopane was present in the bitumen and in the pryolysate of the asphaltenes, it was not detected in the pyrolysates of the kerogen. A C40-isoprenoid with "head to head" linkage, however, was present in pyrolysates of both kerogen and asphaltenes, but not in the bitumen from the diatomite. The maturation level of the bitumen, based on the extent of isomerization of steranes and hopanes, was that of a mature oil, whereas the pyrolysate from the kerogen showed a considerably lower maturation level. These relationships indicate that the bitumen may not be indigenous to the diatomite and that it is a mature oil that migrated into the rock. We consider the possibility, however, that some of the 28,30-bisnorhopane-rich Monterey Formation oils have not been generated through thermal degradation of kerogen, but have been expelled from the source rock at an early stage of diagenesis.

  9. Chemoprevention of Colonic Aberrant Crypt Foci by Novel Schiff Based Dichlorido(4-Methoxy-2-{[2-(Piperazin-4-Ium-1-Yl)Ethyl]Iminomethyl}Phenolate)Cd Complex in Azoxymethane-Induced Colorectal Cancer in Rats.

    Science.gov (United States)

    Hajrezaie, Maryam; Shams, Keivan; Moghadamtousi, Soheil Zorofchian; Karimian, Hamed; Hassandarvish, Pouya; Emtyazjoo, Mozhgan; Zahedifard, Maryam; Majid, Nazia Abdul; Mohd Ali, Hapipah; Abdulla, Mahmood Ameen

    2015-07-23

    Schiff-based complexes as a source of cancer chemotherapeutic compounds have been subjected to the variety of anticancer studies. The in-vitro analysis confirmed the CdCl2(C14H21N3O2) complex possess cytotoxicity and apoptosis induction properties in colon cancer cells, so lead to investigate the inhibitory efficiency of the compound on colonic aberrant crypt foci (ACF). Five groups of adult male rats were used in this study: Vehicle, cancer control, positive control groups and the groups treated with 25 and 50 mg/kg of complex for 10 weeks. The rats in vehicle group were injected subcutaneously with 15 mg/kg of sterile normal saline once a week for 2 weeks and orally administered with 5% Tween-20 (5 ml/kg) for 10 weeks, other groups were injected subcutaneously with 15 mg/kg azoxymethane once a week for 2 weeks. The rats in positive groups were injected intra-peritoneally with 35 mg/kg 5-Flourouracil four times in a month. Administration of the complex suppressed total colonic ACF formation up to 73.4% (P < 0.05). The results also showed that treatment with the complex significantly reduced the level of malondialdehyde while increasing superoxide dismutase and catalase activities. Furthermore, the down-regulation of PCNA and Bcl2 and the up-regulation of Bax was confirmed by immunohistochemical staining.

  10. Effect of two human growth hormone receptor antagonists on glomerulosclerosis in streptozotocin-induced diabetic rats

    Institute of Scientific and Technical Information of China (English)

    Wei LI; Shui-xian SHEN; Li-hua ZHU; En-bi WANG; Zeng-can YE; Jun LIN; Li-he GUO; Fei-hong LUO; Xi-hong LIU; Xin FANG

    2004-01-01

    AIM: To explore the feasibility of human growth hormone (hGH) receptor antagonist in the treatment of end-stage diabetic renal complications. METHODS: Two hGH mutants, hGHA1 (Cys-hGH-dell-4, G120R, K168A, E174A,C182S, de1186-191) and hGHA2 (hGH-H21A, G120R, E174A) were expressed in E coli. The IC50 (Mean±SD)values for the mutants for inhibiting 125I-hGH binding to rabbit growth hormone receptor were (65±10) ng for hGHA1, (27±5.6) ng for hGHA2, and (10±0.6) ng for wild type hGH, respectively. RESULTS: After treatment for 12 weeks, the renal histology analysis showed that treatment with hGHA2 at 4 mg/kg body weight daily markedly suppressed glomerulosclerosis in streptozotocin-induced diabetic Sprague-Dawley (SD) rats; hGHA1 at the same dosage slightly increased the renal damage compared with saline; while wild type hGH at 1 U/kg body weight daily severely worsened the glomerulo-sclerosis in diabetic SD rats. CONCLUSION: The data indicated that hGHA2 inhibited the end-stage glomerulosclerosis in diabetic rats, but hGHA1 mildly increased the glomerulosclerosis.

  11. Enhancement of nisin, lysozyme, and monolaurin antimicrobial activities by ethylenediaminetetraacetic acid and lactoferrin.

    Science.gov (United States)

    Branen, Jill K; Davidson, P Michael

    2004-01-01

    A microtiter plate assay was employed to systematically assess the interaction between ethylenediaminetetraacetic acid (EDTA) or lactoferrin and nisin, lysozyme, or monolaurin against strains of Listeria monocytogenes, Escherichia coli, Salmonella enteritidis, and Pseudomonas fluorescens. Low levels of EDTA acted synergistically with nisin and lysozyme against L. monocytogenes but EDTA and monolaurin interacted additively against this microorganism. EDTA synergistically enhanced the activity of nisin, monolaurin, and lysozyme in tryptic soy broth (TSB) against two enterohemorrhagic E. coli strains. In addition, various combinations of nisin, lysozyme, and monolaurin with EDTA were bactericidal to some gram-negative bacteria whereas none of the antimicrobials alone were bactericidal. Lactoferrin alone (2000 microg ml(-1)) did not inhibit any of the bacterial strains, but did enhance nisin activity against both L. monocytogenes strains. Lactoferrin in combination with monolaurin inhibited growth of E. coli O157:H7 but not E. coli O104:H21. While lactoferrin combined with nisin or monolaurin did not completely inhibit growth of the gram-negative bacteria, there was some growth inhibition. All combinations of EDTA or lactoferrin with antimicrobials were less effective in 2% fat UHT milk than in TSB. S. enteritidis and P. fluorescens strains were consistently more resistant to antimicrobial combinations. Resistance may be due to differences in the outer membrane and/or LPS structure.

  12. Prevalence of diarrheagenic Escherichia coli in children with diarrhea in Salvador, Bahia, Brazil

    Directory of Open Access Journals (Sweden)

    Marcia Regina Franzolin

    2005-07-01

    Full Text Available We report the frequency of the different diarrheagenic Escherichia coli (DEC categories isolated from children with acute endemic diarrhea in Salvador, Bahia. The E. coli isolates were investigated by colony blot hibridization whit the following genes probes: eae, EAF, bfpA, Stx1, Stx2, ST-Ih, ST-Ip, LT-I, LT-II, INV, and EAEC, as virulence markers to distinguish typical and atypical EPEC, EHEC/STEC, ETEC, EIEC, and EAEC. Seven of the eight categories of DEC were detected. The most frequently isolated was atypical EPEC (10.1% followed by ETEC (7.5%, and EAEC (4.2%. EHEC, STEC, EIEC, and typical EPEC were each detected once. The strains of ETEC, EAEC, and atypical EPEC belonged to a wide variety of serotypes. The serotypes of the others categories were O26:H11 (EHEC, O21:H21 (STEC, O142:H34 (typical EPEC, and O?H55 (EIEC. We also present the clinical manifestations and other pathogenic species observed in children with DEC. This is the first report of EHEC and STEC in Salvador, and one of the first in Brazil.

  13. Hypoglycemic and anti-hyperglycemic study of Ocimum tenuiflorum L. leaves extract in normal and streptozotocin-induced diabetic rats

    Institute of Scientific and Technical Information of China (English)

    Leila Mousavi; Rabeta Mohd Salleh; Vikneswaran Murugaiyah; Mohd Zaini Asmawi

    2016-01-01

    Objective: To investigate the antidiabetic activity of Ocimum tenuiflorum L. (O. tenui-florum) leaves used in the traditional medicine management of diabetes in Malaysia. Methods: O. tenuiflorum leaves were extracted sequentially with hexane, chloroform, ethyl acetate, methanol, and water. The extracts were evaluated in terms of antidiabetic activity by using acute, subcutaneous glucose tolerance, and sub-chronic tests in streptozotocin-induced diabetic rats. The extracts were also subjected to phytochemical analyses. Results: With an acute dose (1 g/kg), the methanol extracts showed significant reduction (31%) in fasting blood glucose (FBG) of the streptozotocin-induced diabetic rats. The FBG-decreasing effect of ethyl acetate extract was more rapid than that of the other extracts;the decreasing rates were 20%after 2 h, 21%after 3 h, and 8%after 5 and 7 h. After 7 h (31%), the effect of methanol extract on FBG was significantly lower than that of metformin. In the subcutaneous glucose tolerance test, only methanol and hexane extracts showed the similarity of metformin in diabetic rats. After 14 days, the effects of these extracts were similar to those of metformin (63.33%). The total flavonoid and phenolic contents of extracts decreased as the polarity of the extraction solvent increased. Conclusions: The results obtained provide support for a possible use of O. tenuiflorum leaves in managing hyperglycemia and preventing the complications associated with it in type 2 diabetic.

  14. 苏云金芽孢杆菌科默尔亚种15A3株的cry基因分析及杀虫特性%Characterization of cry Gene and Broad Spectrum Against Lepidopteran of Bacillus thuringiensis subsp. colmeri 15A3

    Institute of Scientific and Technical Information of China (English)

    陈月华; 任改新; 吴卫辉; 王津红; 刘春勇

    2002-01-01

    筛选的苏云金芽孢杆菌野生菌株15A3经鉴定属血清H-21型科默尔亚种.用PCR及RFLP方法对其cryI类基因分析证明其含有crylAa,crylAc,crylCa,crylD,crylI及cry2六种cry基因,其crylA基因N末端1.45kb片段与已发表的序列有差异.表达晶体蛋白质的分子量分别为130,79,70,65,51和45kD.对家蝇致畸实验证明其不含β-外毒素.发酵液对棉铃虫,甜菜夜蛾,小菜蛾及美国白蛾均具较高的毒力.证明野生的苏云金芽孢杆菌资源中也有具国外工程菌所特有的高效杀虫晶体蛋白基因组合的优良菌株.

  15. Angiotensin II induces kidney inflammatory injury and fibrosis through binding to myeloid differentiation protein-2 (MD2)

    Science.gov (United States)

    Xu, Zheng; Li, Weixin; Han, Jibo; Zou, Chunpeng; Huang, Weijian; Yu, Weihui; Shan, Xiaoou; Lum, Hazel; Li, Xiaokun; Liang, Guang

    2017-01-01

    Growing evidence indicates that angiotensin II (Ang II), a potent biologically active product of RAS, is a key regulator of renal inflammation and fibrosis. In this study, we tested the hypothesis that Ang II induces renal inflammatory injury and fibrosis through interaction with myeloid differentiation protein-2 (MD2), the accessory protein of toll-like receptor 4 (TLR4) of the immune system. Results indicated that in MD2−/− mice, the Ang II-induced renal fibrosis, inflammation and kidney dysfunction were significantly reduced compared to control Ang II-infused wild-type mice. Similarly, in the presence of small molecule MD2 specific inhibitor L6H21 or siRNA-MD2, the Ang II-induced increases of pro-fibrotic and pro-inflammatory molecules were prevented in tubular NRK-52E cells. MD2 blockade also inhibited activation of NF-κB and ERK. Moreover, MD2 blockade prevented the Ang II-stimulated formation of the MD2/TLR4/MyD88 signaling complex, as well as the increased surface binding of Ang II in NRK-52E cells. In addition, Ang II directly bound recombinant MD2 protein, rather than TLR4 protein. We conclude that MD2 is a significant contributor in the Ang II-induced kidney inflammatory injury in chronic renal diseases. Furthermore, MD2 inhibition could be a new and important therapeutic strategy for preventing progression of chronic renal diseases.

  16. Synthesis, Crystal Structure and Magnetic Properties of a New Zn(Ⅱ)-Nitronyl Nitroxide Complex

    Institute of Scientific and Technical Information of China (English)

    JIANG Kai; YANG Rui-Hua; WANG Li-Ya; WANG Yu-Fang

    2008-01-01

    A new complex [Zn(NIT-1'-MeBzIm)Cl2(H2O)] (NIT-1'-MeBzIm = 2-{2'-[(1'-methyl)benzimidazolyl]}-4,4,5,5-tetramethylimidazoline-l-oxyl-3-oxide) has been prepared and structurally characterized by X-ray diffraction method. Crystal data: monoclinic, space group P21/n, Z = 4, C15H21Cl2N4O3Zn, Mr = 441.63, a = 7.2225(10), b = 30.849(4), c = 8.8758(13) (A), β= 103.904(2)°, V = 1919.6(5) A3, Dc = 1.528 g/cm3, μ(MoKα) = 1.579 mm-1, F(000) = 908, R = 0.0436 and wR = 0.1029 for 2456 observed reflections with Ⅰ> 2σ(Ⅰ). X-ray analysis reveals that the Zn(Ⅱ) ion is four-coordinated with a distorted tetrahedron. There also exist H-bonds, π-π piling interactions and weak intermolecular contacts between the NO groups which form a mutual stagger 3-D network configuration. Magnetic investigation reveals that there exists intermolecular antiferro- and ferromagnetic interactions in the title complex.

  17. Synthesis and Structure Characterization of Mn2(CO)6(μ-S2CPiPr3)

    Institute of Scientific and Technical Information of China (English)

    马永强; 陈晓; 李靖; 谢庆兰; 王宏根

    2003-01-01

    The homobinuclear compound Mn2(CO)6(u-S2CPiPr3) has been prepared by the reaction of BrMn(CO)3(u-S2CPiPr3) with NaMn(CO)5 in refluxing THF, and its structure was determined by single-crystal X-ray diffraction. Crystallographic data: C16H21Mn2O6PS2, Mr = 514.30, triclinic, space group Pīwith a = 9.293(3), b = 9.443(3), c = 12.977(4) A。, a = 83.633(5), b= 83.719(5), c= 73.399(5) V = 1081.1(6) A。3, Z = 2, Dc = 1.580 g/cm3, a = 1.463 mm-1, F(000) = 524, the final R = 0.0330 and wR = 0.0729 for 2945 observed reflections with I > 2o(I). The crystal structure determination shows that the ligand can be described as a η2(S, S') chelate to one manganese and a η3(S, C, S') pseudoallyl to the other manganese bridging the Mn-Mn bond asymmetrically.

  18. [Application of the Peusner's network thermodynamics to interpretation of the passive membrane transport of binary non-electrolytic solution: evaluation the P(ij) coefficients of polymeric membrane in polarization concentration conditions].

    Science.gov (United States)

    Slezak, Andrzej

    2011-01-01

    In this paper the Kedem-Katchalsky equations were derived, using hybrid transformation of Peusner's network. These equations were applied to interpretation of a transport through polymeric membrane of binary nonelectrolyte solutions under concentration polarization conditions. The values of coefficients P(ij)* (i, j = 1, 2) were calculated for Nephrophan membrane and aqueous glucose solutions. From the calculations it results that the coefficient values P(11)*, P(12)*, P(21)* and P(22)* are nonlinear depend on a solution concentration (C) and configuration of the membrane system. Moreover, the values of coefficients P(11)*, P(12)*, P(21)* and P(22)* were compared to the values of coefficients H(11), H(12), H(21) and H(22), calculated for conditions of solution homogeneity for the same values C and varied configurations of membrane system. It is shown that a threshold value exists and when exceeded, coefficients relations P(11)*/P(11), P(12)*/P(12) and P(22)/P(22) depend on a configuration of the membrane system.

  19. Efectos de extinción en curvas de rotación de galaxias espirales

    Science.gov (United States)

    Valotto, C.; Giovanelli, R.

    Observations show that the slope of the inner part of the Hα/[NII] rotation curves of disk galaxies is depressed by extinction: at fixed luminosity, the observed slope is in fact seen to depend on the disk inclination to the line of sight. Using a simple extinction model, we are able to reproduce well the observed trends. The model assumes an exponential distribution, both in the radial and z directions, identical for star-forming regions and dust. Fits to the data are optimized by varying the scale height and scale length of absorbers, as well as the disk's central optical depth τo, as seen face-on. The observations indicate that disk central opacity increases with total luminosity. Model fits for the most luminous galaxies (brighter than M-5 log h=-21.4 in the I band) yield τo ≃ 3.5+4.0-2.0, near λ=0.66 μm. The large uncertainty on the inferred value of τo is due to the poorly known characteristics of the distribution of absorbers in the disk, as well as to the likelihood of strong departures from an exponential radial distribution near the galaxy centers.

  20. Synthesis, Properties and Crystal Structure of a Novel Coordinated Polymer: {(H2en)(H3O)[(BiPb(C2O4)4(H2O)2)]·2(H2O)}n

    Institute of Scientific and Technical Information of China (English)

    GUO Wen-Jun; ZHANG Han-Hui; HUANG Chang-Cang; SUN Rui-Qing; CHEN Yi-Ping; CAO Yan-Ning

    2005-01-01

    A novel oxalate compound {(H2en)(H3O)[BiPb(C2O4)4(H2O)2]·2(H2O)}n 1 (en = ethylenediamine) containing lead and bismuth has been synthesized by hydrothermal methods, and structurally characterized by X-ray single-crystal diffraction. It crystallizes in monoclinic, space group P21/c with a = 11.6160(1), b = 12.7426(1), c = 15.5683(5) (A), β = 108.442(4)°, BiPbC10N2O21H21, Mr = 921.46, V = 2186.0(4) (A)3, Z = 4, Dc = 2.800 g/cm3, F(000) = 1712 and μ(MoKα) = 15.837 mm-1. The final R = 0.0502 and wR = 0.1261 for 3391 observed reflections with I > 2(σI). The title com- pound consists of 2-D polyanions and protonized organic amine cations, and they are combined to each other by static attractive force and H-bonds to form the so-called organic-inorganic hybrid material.

  1. Volatilization of arsenic from polluted soil by Pseudomonas putida engineered for expression of the arsM Arsenic(III) S-adenosine methyltransferase gene.

    Science.gov (United States)

    Chen, Jian; Sun, Guo-Xin; Wang, Xiao-Xue; Lorenzo, Víctor de; Rosen, Barry P; Zhu, Yong-Guan

    2014-09-02

    Even though arsenic is one of the most widespread environmental carcinogens, methods of remediation are still limited. In this report we demonstrate that a strain of Pseudomonas putida KT2440 endowed with chromosomal expression of the arsM gene encoding the As(III) S-adenosylmethionine (SAM) methyltransfase from Rhodopseudomonas palustris to remove arsenic from contaminated soil. We genetically engineered the P. putida KT2440 with stable expression of an arsM-gfp fusion gene (GE P. putida), which was inserted into the bacterial chromosome. GE P. putida showed high arsenic methylation and volatilization activity. When exposed to 25 μM arsenite or arsenate overnight, most inorganic arsenic was methylated to the less toxic methylated arsenicals methylarsenate (MAs(V)), dimethylarsenate (DMAs(V)) and trimethylarsine oxide (TMAs(V)O). Of total added arsenic, the species were about 62 ± 2.2% DMAs(V), 25 ± 1.4% MAs(V) and 10 ± 1.2% TMAs(V)O. Volatilized arsenicals were trapped, and the predominant species were dimethylarsine (Me2AsH) (21 ± 1.0%) and trimethylarsine (TMAs(III)) (10 ± 1.2%). At later times, more DMAs(V) and volatile species were produced. Volatilization of Me2AsH and TMAs(III) from contaminated soil is thus possible with this genetically engineered bacterium and could be instrumental as an agent for reducing the inorganic arsenic content of soil and agricultural products.

  2. Distorted octahedral environments in tricarbonylrhenium(I) complexes of 5-[2-(2,4,6-trimethylphenyl)diazen-1-yl]quinolin-8-olate and 5,7-bis[2-(2-methylphenyl)diazen-1-yl]quinolin-8-olate.

    Science.gov (United States)

    Schutte-Smith, Marietjie; Muller, Theunis J; Visser, Hendrik G; Roodt, Andreas

    2013-12-15

    The Re(I) centres of two Re(I)-tricarbonyl complexes, viz. tricarbonyl(pyridine-κN){5-[2-(2,4,6-trimethylphenyl)diazen-1-yl]quinolin-8-olato-κ(2)N(1),O}rhenium(I), [Re(C23H21N4O)(CO)3], (I), and {5,7-bis[2-(2-methylphenyl)diazen-1-yl]quinolin-8-olato-κ(2)N(1),O}tricarbonyl(pyridine-κN)rhenium(I), [Re(C28H23N6O)(CO)3], (II), are facially surrounded by three carbonyl ligands, a pyridine ligand and either a 5-[2-(2,4,6-trimethylphenyl)diazen-1-yl]quinolin-8-olate [in (I)] or a 5,7-bis[2-(2-methylphenyl)diazen-1-yl]quinolin-8-olate [in (II)] ligand, in a slightly distorted octahedral environment. The crystal structure of (I) is stabilized by two intermolecular C-H···O interactions and that of (II) is stabilized by three intermolecular C-H···O hydrogen-bonding interactions.

  3. New Calabi-Yau Manifolds with Small Hodge Numbers

    CERN Document Server

    Candelas, Philip

    2008-01-01

    It is known that many Calabi-Yau manifolds form a connected web. The question of whether all Calabi-Yau manifolds form a single web depends on the degree of singularity that is permitted for the varieties that connect the distinct families of smooth manifolds. If only conifolds are allowed then, since shrinking two-spheres and three-spheres to points cannot affect the fundamental group, manifolds with different fundamental groups will form disconnected webs. We examine these webs for the tip of the distribution of Calabi-Yau manifolds where the Hodge numbers (h^{11}, h^{21}) are both small. In the tip of the distribution the quotient manifolds play an important role. We generate via conifold transitions from these quotients a number of new manifolds. These include a manifold with \\chi =-6 that is an analogue of the Tian-Yau manifold and manifolds with an attractive structure that may prove of interest for string phenomenology. We also examine the relation of some of these manifolds to the remarkable Gross-Pop...

  4. XMM-Newton and UV Detection of OVIII and Broad HI absorption towards PKS 0558-504: a possible WHIM filament

    CERN Document Server

    Nicastro, F; Fields, D; Conciatore, M L; Zappacosta, L; Elvis, M; Mathur, S; Papadakis, I

    2009-01-01

    We present the first likely X-ray detection associated with Broad HI Ly$\\beta$ (BLB) and Ly$\\alpha$ (BLA) absorbers, consistent with being a WHIM filament. The absorber lies along the line of sight to the nearby ($z=0.1372$) Seyfert 1 galaxy PKS 0558-504. The X-ray absorber is marginally detected in two independent XMM-Newton spectra of PKS 0558-504, with a combined single line statistical significance of 2.8$\\sigma$ (2.7$\\sigma$ and 1.2$\\sigma$ in the two spectra, respectively). When fitted with our self-consistent hybrid-photoionization WHIM models, the combined XMM-{\\em Newton} spectrum is consistent with the presence of an OVIII K$\\alpha$ absorber at $z=(0.117 \\pm 0.001)$, with log$T=6.56_{-0.17}^{+0.19}$ K, and logN$_H=(21.5 \\pm 0.3) (Z/Z_{0.01\\odot})^{-1}$ cm$^{-2}$. The lack of detection of associated OVI in the archival FUSE spectrum of PKS 0558-504, allows us to infer a tighter lower limit on the temperature, of log$T>6.52$ K (at 1$\\sigma$). The statistical sigificance of this single X-ray detection ...

  5. Power Test of the Ladder IH-RFQ Accelerator at Peking University

    Institute of Scientific and Technical Information of China (English)

    LU Yuan-Rong; CHEN Wei; NIE Yuan-Cun; LIU Ge; GAO Shu-Li; ZENG Hong-Jin; YAN Xue-Qing; CHEN Jia-Er

    2011-01-01

    A 104-MHz ladder interdigital-H radio frequency quadrupole accelerator (T-IH-RFQ) is developed for applying RFQs to heavy ion implantation and accelerator-based mass spectroscopy in recent years at the Institute of Heavy Ion Physics,Peking University.It could accelerate ions with a mass-to-charge ratio of less than 14,from 2.9 ke V/u to 35.7keV/u within a length of 1.1 m.The T-IH-RFQ cavity operating at H21(0) mode was constructed successfully.Based on a well designed rf power feeding system,the cavity was cold measured and tested with high rf power.In the case of cold measurement,the rf properties were obtained using a vector network analyzer with the help of a perturbation capacitor. During a high power test,the inter-electrode voltage was derived from the energy spectrum of x-rays measured by a high purity Ge detector.The results show that the specific shunt impedance of the T-IH-RFQ cavity reaches 178kΩm,which could meet the requirements of beam dynamics design.

  6. Crystal structure of 3-(3,4,5-tri-meth-oxy-phen-yl)-1,2,3,4-tetra-hydro-cyclo-penta[b]indole-2-carb-oxy-lic acid.

    Science.gov (United States)

    Fernandes, Daniara; Simoni, Deborah de Alencar; Rodrigues, Manoel T; Santos, Marilia S; Coelho, Fernando

    2015-06-01

    In the title compound, C21H21NO5, obtained from a Morita-Baylis-Hillman adduct, the hydrogenated five-membered ring adopts a shallow envelope conformation, with the C atom bearing the carb-oxy-lic acid substituent deviating by 0.237 (1) Å from the mean plane of the other four atoms (r.m.s. deviation = 0.007 Å). The dihedral angle between the fused ring system (all atoms; r.m.s. deviation = 0.057 Å) and the pendant trimeth-oxy benzene ring is 66.65 (3)°. The C atoms of the meta-meth-oxy groups lie close to the plane of the benzene ring [deviations = 0.052 (1) and -0.083 (1) Å], whereas the C atom of the para-meth-oxy group is significantly displaced [deviation = -1.289 (1) Å]. In the crystal, carb-oxy-lic acid inversion dimers generate R 2 (2)(8) loops. The dimers are connected by N-H⋯O hydrogen bonds, forming [011] chains. A C-H⋯O inter-action is also observed.

  7. Crystal structure of 3-(3,4,5-trimethoxyphenyl-1,2,3,4-tetrahydrocyclopenta[b]indole-2-carboxylic acid

    Directory of Open Access Journals (Sweden)

    Daniara Fernandes

    2015-06-01

    Full Text Available In the title compound, C21H21NO5, obtained from a Morita–Baylis–Hillman adduct, the hydrogenated five-membered ring adopts a shallow envelope conformation, with the C atom bearing the carboxylic acid substituent deviating by 0.237 (1 Å from the mean plane of the other four atoms (r.m.s. deviation = 0.007 Å. The dihedral angle between the fused ring system (all atoms; r.m.s. deviation = 0.057 Å and the pendant trimethoxy benzene ring is 66.65 (3°. The C atoms of the meta-methoxy groups lie close to the plane of the benzene ring [deviations = 0.052 (1 and −0.083 (1 Å], whereas the C atom of the para-methoxy group is significantly displaced [deviation = −1.289 (1 Å]. In the crystal, carboxylic acid inversion dimers generate R22(8 loops. The dimers are connected by N—H...O hydrogen bonds, forming [011] chains. A C—H...O interaction is also observed.

  8. Studies of phosphorus Gaussian profile emitter silicon solar cells

    Directory of Open Access Journals (Sweden)

    N. Stem

    2001-01-01

    Full Text Available Considering recent modifications on n-type highly doped silicon parameters, an emitter optimization was made based on one-dimensional models with analytical solutions. In order to get good accuracy, a fifth order approximation has been considered. Two kinds of emitters, homogeneous and non-homogeneous, with phosphorus Gaussian profile emitter solar cells were optimized. According to our results: homogeneous emitter solar cells show their maximum efficiencies (h @ 21.60-21.74%with doping levelsnus = 1x10(19 - 5x10(18 (cm-3 and (1.2-2.0 mum emitter thickness range. Non-homogeneous emitter solar cells provide a slightly higher efficiency (eta = 21.82-21.92%, with Ns = 1x10(20 (cm-3 with 2.0 mum thickness under metal-contacted surface and Ns = 1x10(19 - 5x10(18 (cm-3 with (1.2-2.0 mum thickness range, (sheet resistance range 90-100 W/ under passivated surface. Although non-homogeneous emitter solar cells have a higher efficiency than homogeneous emitter ones, the required technology is more complex and their overall interest for practical applications is questionable.

  9. Synthesis and Crystal Structure of a [Cu(HTren)Cl2]ClO4·H2O Complex (Tren = Tris(2-aminoethyl)amine)

    Institute of Scientific and Technical Information of China (English)

    NIU De-Zhong; MA Heng-Jun; GAO Feng; LU Zai-Sheng; CHEN Jiu-Tong

    2006-01-01

    The title complex [Cu(HTren)Cl2]ClO4·H2O (Tren = tris(2-aminoethyl)amine) was crystal (CuC6H21Cl3N4O5) is of triclinic, space group P-1, with a = 8.2689(2), b = 8.4503(3), c=11.6801(4)(A), a = 96.9350(10), β= 108.2440(10), γ = 90.7550(10)°, V= 768.32(4)(A)3, Z= 2, Mr=399.16, Dc= 1.725 g/cm3,μ= 1.962 mm-1, F(000) = 410, T= 293(2) K, the final R = 0.0479 and wR = 0.1339 for 2659 observed reflections with I > 2σ(I). X-ray single-crystal structure analysis reveals that the copper(Ⅱ) atom adopts a slightly distorted square-pyramidal geometry. The distances between Cu and N atoms (N(1), N(2), N(3)) range from 1.975(4) to 2.116(3)(A). The bond lengths of Cu-Cl(1) and Cu-Cl(2) are 2.309(10) and 2.591(10) (A), respectively. The whole crystal presents a three-dimensional network structure by hydrogen bonds.

  10. Crystal structure of {(S)-1-phenyl-N,N-bis­[(pyridin-2-yl)meth­yl]ethanamine-κ3 N,N′,N′′}bis­(thio­cyanato-κN)zinc from synchrotron data

    Science.gov (United States)

    Lee, Dong Won; Shin, Jong Won

    2017-01-01

    The title ZnII complex, [Zn(NCS)2(C20H21N3)], has been characterized by synchrotron single-crystal diffraction and FT–IR spectroscopy. The central ZnII ion has a distorted square-pyramidal coordination geometry, with three N atoms of the chiral (S) 1-phenyl-N,N-bis­[(pyridin-2-yl)meth­yl]ethanamine (S-ppme) ligand and one N atom of a thio­cyanate anion in the equatorial plane, and one N atom of another thio­cyanate anion at the apical position. The average Zn—NS-ppme and Zn—NNCS bond lengths are 2.183 (2) and 1.986 (2) Å, respectively. In the crystal, inter­molecular C—H⋯S hydrogen bonds and a face-to-face π–π inter­action [centroid–centroid distance = 3.482 (1) Å] link the mol­ecules and give rise to a supra­molecular sheet structure parallel to the ac plane. PMID:28083125

  11. Experimental and theoretical studies of (E)-2-(2-hydroxystyryl)-6-(4-methoxybenzoyl)-5-(4-methoxyphenyl)-1,2,4-triazin-3(2H)-one.

    Science.gov (United States)

    Ceylan, Ümit; Hacıyusufoğlu, Mehmet Emin; Sönmez, Mehmet; Yalçın, Şerife Pınar; Özdemir, Namık

    2015-04-15

    Crystal structure of the title compound, C26H21N3O5, has been synthesized and characterized by FT-IR, (1)H NMR, (13)C NMR and X-ray single crystal determination. The molecular geometry was also calculated by using Gaussian 03 software and structure was optimized by using HF and DFT/B3LYP method with the 6-31G(d) basis sets in ground state. The comparison of the theoretical and experimental geometries of the title compound indicated that the X-ray parameters agree with the theoretically obtained values. It was seen that R(2) value changes from 0.015 to 0.021 Å for bond length and angle. The calculated vibrational frequencies are also in good agreement with the experimental results. The (1)H and (13)C NMR chemical shifts values of (E)-2-(2-hydroxystyryl)-6-(4-methoxybenzoyl)-5-(4-methoxyphenyl)-1,2,4-triazin-3(2H)-one molecule have been calculated by the GIAO method. Besides, molecular electrostatic potential maps (MEP), Mulliken charges and Nonlinear Optical effects (NLO) analysis of the compound have been calculated by the HF and B3LYP/6-31G(d) methods. Copyright © 2015 Elsevier B.V. All rights reserved.

  12. Molecular structure, spectroscopic and quantum chemical studies of 1‧,3‧,3‧-trimethylspiro[benzo[f]chromene-3,2‧-indoline

    Science.gov (United States)

    Asiri, Abdullah M.; Ersanlı, Cem Cüneyt; Şahin, Onur; Arshad, Muhammad Nadeem; Hameed, Salem A.

    2016-05-01

    In this work, synthesis, X-ray single crystal determination, nuclear magnetic resonance (1H NMR and 13C NMR), Ultraviolet-Visible (UV-vis), Fourier transform infrared spectroscopy (FT-IR) and quantum mechanical studies of the 1‧,3‧,3‧-trimethylspiro[benzo[f]chromene-3,2‧-indoline [(C23H21NO), TMSBCI] have been both experimentally and theoretically reported. The molecular structure obtained from X-ray single-crystal analysis of the investigated compound in the ground state has been compared using Hartree-Fock (HF) and density functional theory (DFT) with the functional B3LYP using the 6-31G(d,p) as basis set. In addition to the optimized geometrical structures, atomic charges, molecular electrostatic potential (MEP) and natural bond orbital (NBO) have been investigated by using B3LYP/6-31G(d,p) level of the theoretical approximation for the title compound. The energetic behavior of TMSBCI has been examined in solvent media using polarizable continuum model (PCM). The total dipole moment (μ), the average linear polarizability (α), and the first-order hyperpolarisability (β) values of the investigated molecule have been computed using the same method. The experimental measurements (1H NMR, 13C NMR and UV-vis) have been compared with its corresponding the calculated values (using DFT). Besides, frontier molecular orbitals (FMOs) and thermodynamic properties have also been studied.

  13. Microbial production of a biofuel (acetone-butanol-ethanol) in a continuous bioreactor: impact of bleed and simultaneous product removal.

    Science.gov (United States)

    Ezeji, Thaddeus Chukwuemeka; Qureshi, Nasib; Blaschek, Hans Peter

    2013-01-01

    Acetone butanol ethanol (ABE) was produced in an integrated continuous one-stage fermentation and gas stripping product recovery system using Clostridium beijerinckii BA101 and fermentation gases (CO(2) and H(2)). In this system, the bioreactor was fed with a concentrated sugar solution (250-500 g L(-1) glucose). The bioreactor was bled semi-continuously to avoid accumulation of inhibitory chemicals and products. The continuous system was operated for 504 h (21 days) after which the fermentation was intentionally terminated. The bioreactor produced 461.3 g ABE from 1,125.0 g total sugar in 1 L culture volume as compared to a control batch process in which 18.4 g ABE was produced from 47.3 g sugar. These results demonstrate that ABE fermentation can be operated in an integrated continuous one-stage fermentation and product recovery system for a long period of time, if butanol and other microbial metabolites in the bioreactor are kept below threshold of toxicity.

  14. Urea removal by neonatal hemo(dia)filters in hyperazotemic rabbits.

    Science.gov (United States)

    Gouyon, J B; Françoise, M; Semama, D S; Prévot, A; d'Athis, P; Lallemant, C

    1997-06-01

    Comparison of three neonatal hemo(dia)filters (FH22, Gambro; Minifilter Plus, Amicon; Miniflow 10, Hospal) for removal of urea by venovenous hemofiltration (HF) and venovenous hemodiafiltration (HDF). Filters were successively used for HF with two different blood flows (Qb = 8.3 and 16.6 ml/ min) and for HDF with the two different blood flows and four dialysate flows (Qd = 0.5, 1.0, 2.0, and 3.0 l/h). 21 anesthetized adult New Zealand White rabbits infused with urea. Urea clearance was significantly increased by HDF compared to HF regardless of blood flow, dialysate flow, and the hemo (dia)filter type except in the FH22 group, when blood flow was high and dialysate flow was 0.5 or 1.0 l/h. The FH22 filter allowed the best urea clearance during HF at high blood flow. During the HDF procedures, the Miniflow 10 allowed the highest urea clearance regardless of blood flow and dialysate flow.

  15. The ALHAMBRA Project: A large area multi medium-band optical and NIR photometric survey

    CERN Document Server

    Moles, M; López-Aguerri, J A; Alfaro, E J; Broadhurst, T; Cabrera-Caño, J; Castander, F J; Cepa, J; Cerviño, M; Cristóbal-Hornillos, D; Fernández-Soto, A; Delgado, R M González; Infante, L; Márquez, I; Martínez, V J; Masegosa, J; del Olmo, A; Perea, J; Prada, F; Quintana, J M; Sánchez, S F

    2008-01-01

    (ABRIDGED) We describe the first results of the ALHAMBRA survey which provides cosmic tomography of the evolution of the contents of the Universe over most of Cosmic history. Our approach employs 20 contiguous, equal-width, medium-band filters covering from 3500 to 9700 A, plus the JHKs bands, to observe an area of 4 sqdeg on the sky. The optical photometric system has been designed to maximize the number of objects with accurate classification by SED and redshift, and to be sensitive to relatively faint emission lines. The observations are being carried out with the Calar Alto 3.5m telescope using the cameras LAICA and O-2000. The first data confirm that we are reaching the expected magnitude limits of AB<~25 mag in the optical filters from the blue to 8300 A, and from AB=24.7 to 23.4 for the redder ones. The limit in the NIR is (Vega) K_s~20, H~21, J~22. We expect to obtain accurate redshift values, Delta z/(1+z) <~ 0.03 for about 5x10^5 galaxies with I<~25 (60% complete), and z_med=0.74. This accu...

  16. Th(Ⅳ)、U(Ⅵ)金刚烷胺Schiff碱配合物的合成、表征及抗菌活性%Synthesis, Characterization and Antibacterial Activity of Th(Ⅳ) and U(Ⅵ) Complexes with Schiff Base Derived from Adamantaneamine

    Institute of Scientific and Technical Information of China (English)

    祝智力; 赵国良; 张萍华; 沈丽金

    2005-01-01

    由金刚烷胺缩水杨醛Schiff碱配体(C17H21NO,以HL1表示)和金刚烷胺缩邻香兰素Schiff碱配体(C18H23NO2,以HL2表示)分别与UO2(Ac)2·2H2O和Th(NO3)4·4H2O作用,合成了四种新的配合物(1)[UO2(Ac)2(HL1)4]·1.5H2O,(2)[UO2(Ac)2(HL2)]·1.5H2O,(3)[Th(NO3)4(HL1)2]·H2O,(4)[Th(NO3)4(HL2)2]·H2O.用元素分析、摩尔电导、红外光谱和热重分析进行表征;并对所合成的配合物在DMF中进行了抗菌活性的初步测定,研究表明铀(Ⅵ)配合物有一定的抗菌活性,而钍(Ⅳ)配合物则无抗菌活性.

  17. Shape Memory Polymer Composites of Poly(styrene-b-butadiene-b-styrene Copolymer/Liner Low Density Polyethylene/Fe3O4 Nanoparticles for Remote Activation

    Directory of Open Access Journals (Sweden)

    Yongkun Wang

    2016-11-01

    Full Text Available Magnetically sensitive shape memory poly(styrene-b-butadiene-b-styrene copolymer (SBS/liner low density polyethylene (LLDPE composites filled with various contents of Fe3O4 nanoparticles were prepared. The influence of the Fe3O4 nanoparticles content on the thermal properties, mechanical properties, fracture morphology, magnetic behavior, and shape memory effect of SBS/LLDPE/Fe3O4 composites was systematically studied in this paper. The results indicated that homogeneously dispersed Fe3O4 nanoparticles ensured the uniform heat generation and transfer in the alternating magnetic field, and endowed the SBS/LLDPE/Fe3O4 composites with an excellent magnetically responsive shape memory effect. When the shape memory composites were in the alternating magnetic field (f = 60 kHz, H = 21.21 kA·m−1, the best shape recovery ratio reached 99%, the shape retention ratio reached 99.4%, and the shape recovery speed increased significantly with the increment of Fe3O4 nanoparticles. It is anticipated that tagging products with this novel shape memory composite is helpful for the purpose of an intravascular delivery system in Micro-Electro-Mechanical System (MEMS devices.

  18. Diploptene: an indicator of terrigenous organic carbon in Washington coastal sediments

    Science.gov (United States)

    Prahl, F. G.; Hayes, J. M.

    1992-01-01

    The pentacyclic triterpene 17 beta(H),21 beta(H)-hop-22(29)-ene (diploptene) occurs in sediments throughout the Columbia River drainage basin and off the southern coast of Washington state in concentrations comparable to long-chain plantwax n-alkanes. The same relationship is evident for diploptene and long-chain n-alkanes in soils from the Willamette Valley. Microorganisms indigenous to soils and soil erosion are indicated as the biological source and physical process, respectively, for diploptene in coastal sediments. Similarity between the stable carbon isotopic composition (delta 13CPDB) of diploptene isolated from soil in the Willamette Valley (-31.2 +/- 0.3%) and from sediments deposited throughout the Washington coastal environment (-31.2 +/- 0.5%) supports this argument. Values of delta for diploptene in river sediments are variable and 8-17% lighter, indicating that an additional biological source such as methane-oxidizing bacteria makes a significant contribution to the diploptene record in river sediments. Selective biodegradation resulting from a difference in the physicochemical association within eroded particles can explain the absence of the more-13C-depleted form of diploptene in Washington coastal sediments, but this mechanism remains unproven.

  19. Bis(3,5-dimethyl-1H-pyrazole-κN2bis(3,3′′,5,5′′-tetramethyl-[1,1′:3′,1′′-terphenyl]-2′-carboxylato-κOiron(II dichloromethane monosolvate

    Directory of Open Access Journals (Sweden)

    Yeojin Jeon

    2012-05-01

    Full Text Available In the title compound, [Fe(C23H21O22(C5H8N22]·CH2Cl2, the Fe2+ cation is coordinated by the N atoms of two 3,5-dimethylpyrazole ligands and the carboxylate O atoms from two tetramethylterphenylcarboxylate ligands, forming an FeN2O2 polyhedron with a slightly distorted tetrahedral coordination geometry. Intramolecular N—H...O and C—H...O hydrogen-bonding interactions stabilize the molecular conformation. The dihedral angles formed by the central benzene ring with the outer benzene rings of the terphenyl groups are 47.92 (8, 59.38 (8, 48.24 (8 and 52.37 (8°. The dichloromethane solvent molecule interacts with the complex molecule via a C—H...O hydrogen bond. In the crystal, centrosymmetrically related complex molecules are linked into dimers through pairs of C—H...O hydrogen bonds.

  20. Biological marker distribution in coexisting kerogen, bitumen and asphaltenes in Monterey Formation diatomite, California

    Science.gov (United States)

    Tannenbaum, E.; Ruth, E.; Huizinga, B. J.; Kaplan, I. R.

    1986-01-01

    Organic-rich (18.2%) Monterey Formation diatomite from California was studied. The organic matter consist of 94% bitumen and 6% kerogen. Biological markers from the bitumen and from pyrolysates of the coexisting asphaltenes and kerogen were analyzed in order to elucidate the relationship between the various fractions of the organic matter. While 17 alpha(H), 18 alpha(H), 21 alpha(H)-28,30-bisnorhopane was present in the bitumen and in the pryolysate of the asphaltenes, it was not detected in the pyrolysates of the kerogen. A C40-isoprenoid with "head to head" linkage, however, was present in pyrolysates of both kerogen and asphaltenes, but not in the bitumen from the diatomite. The maturation level of the bitumen, based on the extent of isomerization of steranes and hopanes, was that of a mature oil, whereas the pyrolysate from the kerogen showed a considerably lower maturation level. These relationships indicate that the bitumen may not be indigenous to the diatomite and that it is a mature oil that migrated into the rock. We consider the possibility, however, that some of the 28,30-bisnorhopane-rich Monterey Formation oils have not been generated through thermal degradation of kerogen, but have been expelled from the source rock at an early stage of diagenesis.

  1. Chemical activation of Lactoperoxidase system on preservation of raw milk at ambient temperature%室温下化学法激活乳过氧化物酶体系对原料乳品质的影响

    Institute of Scientific and Technical Information of China (English)

    胡晓宇; 陈梅仙; 卢蓉蓉; 张国农

    2007-01-01

    本文对化学法激活乳过氧化物酶体系用于室温下原料乳保鲜进行了研究.研究结果表明,在25℃贮藏温度下,原料奶的货架期随着SCN-和H2O2的浓度增加而增加.对照组和实验组0.1 mol/L,0.25 mmol/L,0.5 mmol/L的保鲜期分别为19 h,19.5 h,21.5 h和23.5 h.在贮藏期间,所有的实验组的微生物数量均低于对照组.11.5 h时,激活剂浓度为0.25 mmol/L和0.5 mmol/L的原料乳的菌落总数比对照组提高了3个卫生等级.在14h时,激活剂浓度为0.25 mmol/L和0.5 mmol/L的实验组比对照组的大肠菌群数分别低1.2和1.75个对数周期.

  2. Synthesis and crystal Structure of 2[1-(1,1-dimethylethyl)-5-methyl-1-H-pyrazol-4-ylcarbonyl]-N-Phenyldrazinecarbothioamide

    Institute of Scientific and Technical Information of China (English)

    李明; 文丽荣; 付维军; 赵桂龙; 杨华铮

    2004-01-01

    The crystal structure of 2[1-(1,1-dimethylethyl)-5-methyl-1-H-pyrazol-4-ylcar-bonyl]-N-phenyldrazinecarbothioamide ([C16H21N5OS]·CH3COCH3,C19H27N5O2S,Mr=389.52) has been determined by single-crystal X-ray diffraction.The crystal belongs to tetragonal,space group I41/a with a=23.960(4),b=23.960(4),c=16.120(5)A,V=9254(4)A3,Z=16,Dc=1.118 g/cm3,μ=0.161 mm-1,F(000)=3328,R=0.0660 and wR=0.1305 for 3878 unique reflections with 1653 observed ones (I > 2σ(I)).The intermolecular hydrogen bond between N(3)-H(3B)…O(1),N(5)-H(5A)…S(1) and N(4)-H(4D)…O(2) has been observed.

  3. The effect of early detection of anterolateral thigh free flap crisis on the salvage success rate, based on 10 years of experience and 1072 flaps.

    Science.gov (United States)

    Yang, Q; Ren, Z H; Chickooree, D; Wu, H J; Tan, H Y; Wang, K; He, Z J; Gong, C J; Ram, V; Zhang, S

    2014-09-01

    The aim of this study was to assess the effectiveness of early exploration of anterolateral thigh (ALT) free flap compromise in head and neck reconstruction and to correlate this with the salvage success rate. The perioperative data of 1051 patients with 1072 ALT flap reconstructions were reviewed retrospectively for the period January 2002 to December 2012. Outcome measures included ethnicity, defect type, incidence and timing of flap compromise, type of flap compromise, causes of vascular occlusion, and salvage rate. The success rate of free flap reconstruction was 97.3% (1043/1072). Of the 29 failures, 21 were complete and eight were partial failures (10-40% of the flap). Venous occlusions occurred in 39 flaps (83.0%) and arterial occlusions in five flaps (17.0%). Six cases were detected within 8h postoperatively, 13 at 8-16 h postoperatively, seven at 16-24h postoperatively, and 18 at 24-48 h postoperatively, with respective salvage rates of 66.7%, 61.5%, 28.6%, and 22.2%; three cases detected after 48 h failed. The salvage rate at ≤16 h (62.2%) was much higher than that at >16 h (21.4%, P=0.0039). Early detection, re-exploration, and effective handling of the flap crisis increases the rate of flap salvage tremendously.

  4. Crystal structure of (4-meth-oxy-phen-yl)[(4-meth-oxy-phen-yl)phospho-nato]dioxidophosphate(1-) 2-amino-6-benzyl-3-eth-oxy-carbon-yl-4,5,6,7-tetra-hydro-thieno[2,3-c]pyridin-6-ium.

    Science.gov (United States)

    Mague, Joel T; Mohamed, Shaaban K; Akkurt, Mehmet; Younes, Sabry H H; Ahmed, Essam K; Albayati, Mustafa R

    2015-12-01

    The asymmetric unit of the title mol-ecular salt, C17H21N2O2S(+)·C14H15O7P2 (-), comprises two cations and two anions. Each cation features an intra-molecular N-H⋯O hydrogen bond, which closes an S(6) ring; in each case the hydro-pyridine ring adopts a half-chair conformation. In the anions, the dihedral angles between the aromatic rings are 64.1 (2) and 54.9 (2)°. In each case, the diphosphate groups are close to eclipsed [C-P⋯P-C pseudo-torsion angles = 11.6 (2) and -19.3 (2)°]. One of the meth-oxy groups in each anion is disordered over two orientations in a 0.539 (18):0.461 (18) ratio in one anion and 0.82 (2):0.18 (2) in the other. In the crystal, O-H⋯O and N-H⋯O hydrogen bonds link the components into [100] chains. Numerous C-H⋯O inter-actions cross-link the chains into a three-dimensional network.

  5. $\\eta$ Carinae Baby Homunculus Uncovered by ALMA

    CERN Document Server

    Abraham, Zulema; Beaklini, Pedro P B

    2014-01-01

    We report observations of $\\eta$ Carinae obtained with ALMA in the continuum of 100, 230, 280 and 660 GHz in 2012 November, with a resolution that varied from 2.88" to 0.45" for the lower and higher frequencies respectively. The source is not resolved, even at the highest frequency; its spectrum is characteristic of thermal bremsstrahlung of a compact source, but different from the spectrum of optically thin wind. The recombination lines H42$\\alpha$, He42$\\alpha$, H40$\\alpha$, He40$\\alpha$, H50$\\beta$, H28$\\alpha$, He28$\\alpha$, H21$\\alpha$ and He21$\\alpha$ were also detected and their intensities reveal non local thermodynamic equilibrium (NLTE) effects. We found that the line profiles could only be fit by an expanding shell of dense and ionized gas, which produces a slow shock in the surroundings of $\\eta$ Carinae. Combined with fittings to the continuum, we were able to constrain the shell size, radius, density, temperature and velocity. The detection of the He recombination lines is compatible with the hi...

  6. μ3-Iodo-tri-μ3-sulfido-sulfidotris[tris(4-methoxyphenylphosphine-κP]tricopper(Itungsten(VI N,N-dimethylformide solvate

    Directory of Open Access Journals (Sweden)

    Guodong Tang

    2008-01-01

    Full Text Available A new W/S/Cu cluster, [Cu3WIS4(C21H21O3P3]·C3H7NO, was formed by the reaction of ammonium tetrathiotungstate(VI, cuprous iodide and tris(4-methoxyphenylphosphine in N,N-dimethylformamide. The title compound exhibits a heavily distorted cubane-like skeleton in which the average Cu—I, Cu—S and W—μ3-S distances are 2.934, 2.302 and 2.249 Å, respectively. The W atom exhibits tetrahedral geometry, formed by three μ3-S and one terminal S atom; the W—S(terminal bond length is 2.1426 (13 Å. Each Cu atom is coordinated by one P atom from a tris(4-methoxyphenylphosphine (mop, two μ3-S and one μ3-I atom, forming a distorted tetrahedral coordination geometry. Some of the mop ligand methyl groups have large librations. Together with the three neutral mop ligands, the title compound is neutral; this contrasts with the all-halogen-coordinated Mo/S/Ag clusters with the same structure, which carry negative charge.

  7. Tamarugite in the Steam-Condensate Alteration Paragenesis in Diana Cave (SW Romania)

    Science.gov (United States)

    Puscas, C. M.; Onac, B. P.; Effenberger, H. S.; Povară, I.

    2012-12-01

    The double-salt hydrate tamarugite [NaAl(SO4)2 6H2O] is an uncommon mineral in the cave environment, forming as a result of chemical reactions between water and bedrock only under very specific conditions. The Diana Cave hosts a unique tamarugite occurrence, the first one to be reported from a typical karst environment. The cave is located within the limits of Băile Herculane township in the Cerna Mountains, SW Romania. It consists of a 14 m long, westward-oriented single passage, developed along the Diana Fault. In 1974 a concrete-clad mine gallery was created to channel the thermal water (Diana 1+2 Spring) flowing through the cave to a pumping station. The spring's chemical and physical parameters fluctuated through time, averaging 51.98° C, discharge of 0.96 Ls-1, pH of 7.46, 5768.66 ppm TDS, 9303 μScm-1 conductivity, 5.02 salinity. The major chemical components of the thermo-mineral water in Diana Cave are, Na+ (1392.57 ppm), K+ (58.55 ppm), Ca2+ (725.16 ppm), Mg2+ (10.78 ppm), Cl- (3376.83 ppm), and SO42- (92.27 ppm), and H2S (24.05 ppm), with traces of Si, Fe2+, Br+, I-, and Li+. The general air circulation pattern within the cave is fairly simple: cold air from the outside sweeps into the cave along the floor, heats up at the contact with the thermo-mineral water, ascends, and exists the cave along the ceiling. At the contact with the cold walls of the Diana Cave, the hot steam condenses and gives rise to a rich and exotic sulfate-mineral paragenesis (including halotrichite-series minerals, gypsum, bassanite, anhydrite, epsomite, alunite, halite, native sulfur, etc.). The most exotic minerals precipitate at or below the contact between the Tithonic - Neocomian limestone and the overlaying Cretaceous shaly limestone, as a result of steam-condensate alteration. Minerogenetic mechanisms responsible for the peculiar sulfate mineral assemblage in Diana Cave are evaporation, oxidation, hydrolysis, double exchange reactions, and deposition from vapours or

  8. Reconstruction of External Auditory Meatus (Re-EAMs) and Tympanoplasty for、Patients with Congenital Deformation of the Middle and Outer Ears%先天性中外耳畸形外耳道再造与鼓室成形术

    Institute of Scientific and Technical Information of China (English)

    邹艺辉; 杨仕明; 戴朴; 韩维举; 韩东一

    2014-01-01

    Objective To explore the hearing improvement after reconstruction of external auditory meatus (Re-EAMs) and tympanoplasty for patients with congenital deformation of the middle and outer ears, and provide reference for later treat⁃ment to these kinds of patients. Methods a retrospective analysis of 41 cases (41 ears) with preoperative and postoperative hearing findings undergone Re-EAMs and tympanoplasty patients with congenital deformation of the middle and outer ears in General Hospital of PLA during 2006.7-2012.12. Results The methods for operations were Ossicular chain loosening 41.5%(17/41),Porp implantation 46.3%(19/41), Torp implantation 7.3%(3/41) and inner ear fenestration 4.9%(2/41),with average air conduction hearing threshold pre-and post-operation for 0.5k、1k、2k、4k (58 dB/53dB),(64 dB/52dB),(73 dB/73dB)and (62 dB/46dB)respectively. Conclusion Hearing improvement is not obvious after ossicular chain loosening and Torp implan⁃tation, while significant for Porp implantation and inner ear fenestration, but can’t reach the normal hearing threshold level.%目的:探索先天性中外耳畸形患者耳道再造与鼓室成形术后听力改善情况,为此类患者方案选择提供参考。方法回顾性分析2006年6月~2012年12月我们进行外耳道再造与鼓室成形患者中有术前术后听力的41例(41耳)的情况。结果手术采用听骨链松解41.5%(17/41),Porp植入46.3%(19/41),Torp植入7.3%(3/41),内耳开窗4.9%(2/41)。术前术后0.5k、1k、2k、4k平均气导听阈值分别为(58 dB/53dB),(64 dB/52dB),(73 dB/73dB),(62 dB/46dB).结论听骨链松解与Torp植入术后听力改善不明显,Porp植入和内耳开窗术后听力有明显改善,但未能达到正常听阈水平。

  9. 含苯四甲酸的邻菲啰啉铜配合物的合成、晶体结构及电化学性质研究%Synthesis, Crystal Structure and Electrochemical Property of Copper Complex Based on 1,10-Phenanthroline and 1,2,4,5-Benzenetetracarboxylic Acid

    Institute of Scientific and Technical Information of China (English)

    朱禹; 黄文浩; 朱敏; 吴云龙; 谢吉民

    2013-01-01

    A Cu(Ⅱ) complex [Cu (phen)2Br] (H3BTEC) (1,phen =1,10-phenanthroline,H4BTEC =1,2,4,5-benzenetetracarboxylic acid) was synthesized,and charactered by elemental analysis,IR spectra,UV-Vis spectra,single crystal X-ray diffraction,TG analysis and electrochemical property.The complex crystallizes in triclinic,space group P1 with a=0.971 00(19) nm,b=1.212 0(2) nm,c=1.4290(3) nm; α=102.21(3)°,β=99.57(3)°,γ=107.64(3)°,V=1.51774(7) nm3,Z=2,C34H21BrCuN4O8,Mr=757,Dc=1.656 g·cm-3,μ=2.098 mm-1,F(000)=762,S=1.059,the final R=0.044 9 and wR=0.086 4 for 4 657 observed reflections with I>2o(I).Two types of one-dimensional chains are demonstrated in the structure.On one hand,the C-H… Br hydrogen bonds and Br…π stacking interactions connect the [Cu(phen)2Br]+ cations into one-dimensional chains; on the other hand,the O-H… O hydrogen bonds aggregate the mono-deprotonated anions into one-dimensional double-layer chains.The two different kinds of chains are further packed into a three-dimensional framework with C-H…O contacts.CCDC:858948.%本文合成了铜配合物[Cu(phen)2Br](H3BTEC)(1,phen=1,10-phenanthroline,H4BTEC=1,2,4,5-benzenetetracarboxylic acid),并对其进行了元素分析、红外、紫外、单晶衍射、热重和电化学性质等表征.测定结果表明,该配合物晶体属三斜晶系,空间群P(1-),晶胞参数a=0.971 00(19) nm,b=1.212 0(2) nm,c=1.429 0(3) nm;α=102.21 (3)°,β=99.57(3)°,γ=107.64(3)°,V=1.517 74(7) nm3,Z=2,C34H21BrCuN4O8,M=757,Dc=1.656 g·cm-3,μ=2.098 mm-1,F(000)=762,S=1.059,最终偏离因子R=0.044 9,wR=0.086 4.该配合物中发现了两种不同类型的一维链.一方面,氢键(C-H…Br)和Br…π堆积作用将[Cu(phen)2Br]+连接成一个一维阳离子链;另外,分子间的O-H…O氢键将均苯四甲酸连成一个双层的一维阴离子链.通过结构中的C-H…O氢键作用及其他弱作用将这两条不同的一维链堆积成一个三维结构.

  10. 电导法对32个辣椒品种组合抗寒性的测定及配合力分析%Determination and Combining Ability Analysis of Cold Resistance of 32 Combinations of Hot Peper Hybrid by Electric Conductivity

    Institute of Scientific and Technical Information of China (English)

    杨少瑕; 吕庆芳; 梁春林

    2014-01-01

    为了比较辣椒品种的抗寒性,以32个线椒杂交组合为试材,在人工气候箱下进行低温处理,应用电导法测定叶片相对电导率(REC)。通过Logistic曲线方程拟合求出拐点温度(即半致死温度)(LT50),作为各试材抗寒性评价的参考指标,并将32个线椒组合的半致死温度(L T50)进行比较。结果表明:随处理温度的降低,相对电导率不断升高,变化过程呈“S”型曲线。32个线椒组合抗寒性顺序依次为:H2> H13≈ H28> H31≈H1≈H23> H24> H26> H30> H8> H27≈ H19> H5≈ H12> H21> H3> H18> H15≈ H14> H22> H17>H7≈H29> H4> H11> H10≈H16> H20> H6> H9> H25> H32。配合力分析表明,相对电导率的GCA效应值以亲本P1和P2最低,SCA效应值以P1× P2最低。%In order to compare the cold resistance of the hot pepper varieties ,taking 32 combinations of hot pep-per hybrid as materials ,the relative electrical conductivity was deteriminated under low temperature in artificial climatic .The turning point temperature(semi-lethal temperature)was measured by Logistic equation and used as the index of cold-tolerance for all hybrid combinations ,the semi-lethal temperatures were compared .The re-sults showed that relative conductivity was increasing with the decrease of temperature ,change processing was in an S curve .The order of cold resistance of hot peppers was H2> H13≈ H28> H31≈ H1≈ H23> H24>H26> H30> H8> H27≈ H19> H5≈H12> H21> H3> H18> H15≈ H14> H22> H17> H7≈ H29> H4>H11> H10≈ H16> H20> H6> H9> H25> H32 .Combining ability analysis showed that the lowest GCA effect of relative conductivity was parent P1 and P2 ,the lowest SCA was P1 × P2 .

  11. Crystallographic investigations of select cathinones: emerging illicit street drugs known as `bath salts'.

    Science.gov (United States)

    Wood, Matthew R; Lalancette, Roger A; Bernal, Ivan

    2015-01-01

    The name `bath salts', for an emerging class of synthetic cathinones, is derived from an attempt to evade prosecution and law enforcement. These are truly illicit drugs that have psychoactive CNS (central nervous system) stimulant effects and they have seen a rise in abuse as recreational drugs in the last few years since first having been seen in Japan in 2006. The ease of synthesis and modification of specific functional groups of the parent cathinone make these drugs particularly difficult to regulate. MDPV (3,4-methylenedioxypyrovalerone) is commonly encountered as its hydrochloride salt (C16H21NO3·HCl), in either the hydrated or the anhydrous forms. This `bath salt' has various names in the US, e.g. `Super Coke', `Cloud Nine', and `Ivory Wave', to name just a few. We report here the structures of two forms of the HCl salt, one as a mixed bromide/chloride salt, C16H22NO3(+)·0.343Br(-)·0.657Cl(-) [systematic name: 1-(benzo[d][1,3]dioxol-5-yl)-2-(pyrrolidin-1-ium-1-yl)pentan-1-one bromide/chloride (0.343/0.657)], and the other with the H7O3(+) cation, as well as the HCl counter-ion [systematic name: hydroxonium 1-(benzo[d][1,3]dioxol-5-yl)-2-(pyrrolidin-1-ium-1-yl)pentan-1-one dichloride, H7O3(+)·C16H22NO3(+)·2Cl(-)]. This is one of a very few structures (11 to be exact) in which we have a new example of a precisely determined hydroxonium cation. During the course of researching the clandestine manufacture of MDPV, we were surprised by the fact that a common precursor of this illicit stimulant is known to be the fragrant species piperonal, which is present in the fragrances of orchids, most particularly in the case of the vanilla orchid. We found that MDPV can be made by a Grignard reaction of this heliotropin. This may also explain the unexpected appearance of the bromide counter-ion in some of the salts we encountered (C16H21NO3·HBr), one of which is presented here [systematic name: 1-(benzo[d][1,3]dioxol-5-yl)-2-(pyrrolidin-1-ium-1-yl)pentan-1-one

  12. Influência do período de alimentação no consumo e ganho de peso do pirarucu Influence of feeding period on consumption and weight gain of pirarucu

    Directory of Open Access Journals (Sweden)

    Roger Crescêncio

    2005-12-01

    Full Text Available O objetivo deste trabalho foi verificar o período preferencial de consumo alimentar do pirarucu, Arapaima gigas, e a influência de diferentes turnos de alimentação no consumo e ganho de peso dessa espécie. Foram testados três tratamentos: alimentação diurna (peixes alimentados às 9h e 15h, alimentação noturna (peixes alimentados às 21h e 3h e alimentação contínua (peixes alimentados às 9h, 15h, 21h e 3h. Cada tratamento foi avaliado em triplicata, com cada unidade experimental formada por oito peixes, com peso médio de 313 g, estocados em tanques-redes de 1 m³ (1x1x1 m. Os nove tanques-redes foram alocados em um viveiro escavado de 120 m². O experimento durou 60 dias. A alimentação contínua promoveu maiores ganhos de peso e biomassa, taxa de crescimento específico e consumo total. Os tratamentos alimentação diurna e alimentação noturna apresentaram ganho de peso semelhante, porém, a alimentação diurna apresentou a melhor conversão alimentar. O período preferencial de alimentação do pirarucu foi o noturno, principalmente no começo da noite. Os dados deste estudo indicam que o horário de preferência alimentar não é o melhor horário de alimentação do pirarucu, em uma criação comercial. O período de alimentação mais indicado para a espécie, baseado na capacidade de conversão alimentar, é o diurno.The objective of this study was to verify pirarucu Arapaima gigas preferential time of feeding, and the influence of different feeding periods on consumption and weight gain of this species. Three treatments were tested: diurnal feeding (fish fed at 9h and 15h, nocturnal feeding (fish fed at 21h and 3h, and continuous feeding (fish fed at 9h, 15h, 21h and 3h. Each treatment was evaluated in triplicate, and each trial unit had eight fishes with 313 g average weight, stoked into a 1 m³ (1x1x1 m net cage. The nine net cages were located on a 120 m² earth pond. The trial lasted for 60 days. Continuous feeding

  13. Assessment of extreme quantitative precipitation forecasts and development of regional extreme event thresholds using data from HMT-2006 and COOP observers

    Science.gov (United States)

    Ralph, F.M.; Sukovich, E.; Reynolds, D.; Dettinger, M.; Weagle, S.; Clark, W.; Neiman, P.J.

    2010-01-01

    Extreme precipitation events, and the quantitative precipitation forecasts (QPFs) associated with them, are examined. The study uses data from the Hydrometeorology Testbed (HMT), which conducted its first field study in California during the 2005/06 cool season. National Weather Service River Forecast Center (NWS RFC) gridded QPFs for 24-h periods at 24-h (day 1), 48-h (day 2), and 72-h (day 3) forecast lead times plus 24-h quantitative precipitation estimates (QPEs) fromsites in California (CA) and Oregon-Washington (OR-WA) are used. During the 172-day period studied, some sites received more than 254 cm (100 in.) of precipitation. The winter season produced many extreme precipitation events, including 90 instances when a site received more than 7.6 cm (3.0 in.) of precipitation in 24 h (i.e., an "event") and 17 events that exceeded 12.7 cm (24 h)-1 [5.0 in. (24 h)-1]. For the 90 extreme events f.7.6 cm (24 h)-1 [3.0 in. (24 h)-1]g, almost 90% of all the 270 QPFs (days 1-3) were biased low, increasingly so with greater lead time. Of the 17 observed events exceeding 12.7 cm (24 h)-1 [5.0 in. (24 h)-1], only 1 of those events was predicted to be that extreme. Almost all of the extreme events correlated with the presence of atmospheric river conditions. Total seasonal QPF biases for all events fi.e., $0.025 cm (24 h)-1 [0.01 in. (24 h)-1]g were sensitive to local geography and were generally biased low in the California-Nevada River Forecast Center (CNRFC) region and high in the Northwest River Forecast Center(NWRFC) domain. The low bias in CA QPFs improved with shorter forecast lead time and worsened for extreme events. Differences were also noted between the CNRFC and NWRFC in terms of QPF and the frequency of extreme events. A key finding from this study is that there were more precipitation events .7.6 cm (24 h)-1 [3.0 in. (24 h)21] in CA than in OR-WA. Examination of 422 Cooperative Observer Program (COOP) sites in the NWRFC domain and 400 in the CNRFC domain

  14. Exercise and improved insulin sensitivity in older women: evidence of the enduring benefits of higher intensity training.

    Science.gov (United States)

    DiPietro, Loretta; Dziura, James; Yeckel, Catherine W; Neufer, P Darrell

    2006-01-01

    Few studies have compared the relative benefits of moderate- vs. higher intensity exercise training on improving insulin sensitivity in older people while holding exercise volume constant. Healthy older (73 +/- 10 yr) women (N = 25) who were inactive, but not obese, were randomized into one of three training programs (9-mo duration): 1) high-intensity [80% peak aerobic capacity (V(O2)peak); T(H)] aerobic training; 2) moderate-intensity (65% V(O2)peak; T(M)) aerobic training; or 3) low-intensity (stretching) placebo control (50% V(O2)peak); C(TB)). Importantly, exercise volume (300 kcal/session) was held constant for subjects in both the T(H) and the T(M) groups. V(O2)peak was determined by using a graded exercise challenge on a treadmill. Total body fat and lean mass were determined with dual-energy X-ray absorptiometry. The rate of insulin-stimulated glucose utilization as well as the suppression of lipolysis were determined approximately 72 h after the final exercise bout by using a two-step euglycemic-hyperinsulinemic clamp. We observed improved glucose utilization at the higher insulin dose with training, but these improvements were statistically significant only in the T(H) (21%; P = 0.02) compared with the T(M) (16%; P = 0.17) and C(TB) (8%; P = 0.37) groups and were observed without changes in either body composition or V(O2)peak. Likewise in the T(H) group, we detected a significant improvement in insulin-stimulated suppression (%) of adipose tissue lipolysis at the low-insulin dose (38-55%, P < 0.05). Our findings suggest that long-term higher intensity exercise training provides more enduring benefits to insulin action compared with moderate- or low-intensity exercise, likely due to greater transient effects.

  15. Protection against Shiga-Toxigenic Escherichia coli by Non-Genetically Modified Organism Receptor Mimic Bacterial Ghosts.

    Science.gov (United States)

    Paton, Adrienne W; Chen, Austen Y; Wang, Hui; McAllister, Lauren J; Höggerl, Florian; Mayr, Ulrike Beate; Shewell, Lucy K; Jennings, Michael P; Morona, Renato; Lubitz, Werner; Paton, James C

    2015-09-01

    Shiga-toxigenic Escherichia coli (STEC) causes severe gastrointestinal infections in humans that may lead to life-threatening systemic sequelae, such as the hemolytic uremic syndrome (HUS). Rapid diagnosis of STEC infection early in the course of disease opens a window of opportunity for therapeutic intervention, for example, by administration of agents that neutralize Shiga toxin (Stx) in the gut lumen. We previously developed a recombinant bacterium that expresses a mimic of the Stx receptor globotriaosyl ceramide (Gb3) on its surface through modification of the lipopolysaccharide (A. W. Paton, R. Morona, and J. C. Paton, Nat Med 6:265-270, 2000, http://dx.doi.org/10.1038/73111). This construct was highly efficacious in vivo, protecting mice from otherwise fatal STEC disease, but the fact that it is a genetically modified organism (GMO) has been a barrier to clinical development. In the present study, we have overcome this issue by development of Gb3 receptor mimic bacterial ghosts (BGs) that are not classified as GMOs. Gb3-BGs neutralized Stx1 and Stx2 in vitro with high efficiency, whereas alternative Gb3-expressing non-GMO subbacterial particles (minicells and outer membrane blebs) were ineffective. Gb3-BGs were highly efficacious in a murine model of STEC disease. All mice (10/10) treated with Gb3-BGs survived challenge with a highly virulent O113:H21 STEC strain and showed no pathological signs of renal injury. In contrast, 6/10 mice treated with control BGs succumbed to STEC challenge, and survivors exhibited significant weight loss, neutrophilia, and histopathological evidence of renal damage. Thus, Gb3-BGs offer a non-GMO approach to treatment of STEC infection in humans, particularly in an outbreak setting.

  16. Effect of grapefruit juice and food on the pharmacokinetics of pirfenidone in healthy Chinese volunteers: a diet-drug interaction study.

    Science.gov (United States)

    Hu, Jinqing; Shang, Dewei; Xu, Xinwen; He, Xiuling; Ni, Xiaojia; Zhang, Ming; Wang, Zhanzhang; Qiu, Chang; Deng, Shuhua; Lu, Haoyang; Zhu, Xiuqing; Huang, Wencan; Wen, Yuguan

    2016-01-01

    1. Ingestion of grapefruit juice and food could be factors affecting the pharmacokinetics of pirfenidone, a promising drug for treatment of idiopathic pulmonary fibrosis. 2. A randomized, open-label, three-period crossover study was carried out in 12 healthy Chinese male volunteers who were randomized to one of the three treatments: pirfenidone tablets (0.4 g) were orally administered to fasted or fed subjects, or with grapefruit juice. The washout period was 7 d. 3. Significantly reduced maximum plasma concentration (Cmax, 5.0 5 ± 1.39 versus 10.9 0 ± 2.94 mg·L(- 1)), modestly affected area-under-the-plasma concentration-time curve (AUC) from time zero to 12 h post dosing (AUC0-12 h, 21.8 9 ± 6.47 versus 26.1 6 ± 7.32 mg·h·L(- 1)) and delayed time to reach Cmax (Tmax) were observed in fed group compared with fasted group. Similar effects on Cmax (5.8 2 ± 1.23 versus 10.9 0 ± 2.94 mg·L(- 1)) and AUC0-12 h (modest but not statistically significant, 24.4 4 ± 7.40 versus 26.1 6 ± 7.32 mg·h·L(- 1)) were observed for grapefruit juice compared to fasted subjects. 4. Co-administration of pirfenidone with grapefruit juice resulted in modestly reduced overall oral absorption and significantly reduced peak concentrations compared to fasting, which was similar to effect of food ingestion. No adverse events were observed in the study, but relatively dramatic reduction of peak concentrations should raise concerns for clinical efficacy and safety.

  17. The clinical observation of three-dimensional conformal radiotherapy combined with FOLFOX chemotherapy for rectal cancer of postoperative local recurrence

    Institute of Scientific and Technical Information of China (English)

    Yeqin Zhou; Mi Liu; Daiyuan Ma; Tao Ren; Xiaojie Ma; Xianfu Li; Bangxian Tan

    2012-01-01

    Objective: The aim of this study was to explore the three-dimensional conformal radiotherapy combined with FOLFOX scheme chemotherapy in the treatment of postoperative recurrence of rectal cancer. Methods: Sixty-eight cases of recurrent rectal cancer were divided randomly into two groups: 34 cases of conformal radiotherapy plus FOLFOX chemotherapy group (experiment group) and 34 cases of conformal radiotherapy (control group). After 6 MvX line with three-dimensional conformal radiotherapy technologies for recurrent lesions and pelvic cavity around subclinical lymphatic drainage radiotherapy after radiotherapy to DT 40 Gy to reposit was made use of between both groups, experiment group was made the new treatment plan to continue to irradiate to 50 Gy, and then Shrinkage GTV was pushed quantity in the field 66 Gy. Researchers took chemotherapy in the first week and the fourth week after radiotherapy, with 5-fluorouracil 500 mg/m2, calcium leucovorin 200 mg, d1-5 with intravenous drip, Oxaliplatin 130 mg/m2 and d1 with intravenous drip 2 h, 21 days was one cycle. Kaplan-Meier method was used for survival analysis. Results: The survival rates for 1, 2 and 3 years for experiment group and control group were 88.2%, 64.7%, 47.1% and 66.7%, 38.2%, 29.4% (P = 0.03), the 2-year rate of distant metastases was 32.4% and 58.8% (P = 0.032) respectively. The median survival time was 33 and 20 months respectively. There were some side effects between the groups, but there was no statistical difference. Conclusion: Three-dimensional conformal radiotherapy plus FOLFOX chemotherapy can be considered as a safe and effective approach to treat rectal cancer patients of postoperative recurrence, and can improve the survival rates of patients and reduce distant metastasis rate obviously and make the acute adverse reaction rate insignificantly.

  18. INTERSCALENE BRACHIAL PLEXUS BLOCK: COMPARISON OF EFFICACY OF VARYING DOSES OF DEXAMETHASONE COMBINED WITH LEVOBUPIVACAINE: A DOUBLE-BLIND RANDOMISED TRAIL.

    Directory of Open Access Journals (Sweden)

    Srinivasa Rao

    2014-06-01

    Full Text Available INTRODUCTION: To compare the effects of adding two different doses of dexamethasone on the duration and quality of interscalene block in patients undergoing shoulder surgery. METHODOLOGY: A total of 90 patients(age 18-65years undergoing shoulder surgery under interscalene block were assigned randomly to one of three groups: Control Group-C received injection levobupivacaine (0.5%, 35ml plus 2 ml normal saline Group-L received injection levobupivacaine (0.5% 35 ml plus dexamethasone 4 mg plus 1 ml normal saline and; Group H received injection levobupivacaine (0.5% 35 ml plus dexamethasone 8 mg. Assessment of motor and sensory blockade, pulse, systolic blood pressure, respiration and side effects were noted every 5 minutes for first 30 minute and every 10 minute till the end of surgery. Postoperative analgesia was assessed using the numeric rating scores [NRS]. RESULTS: The duration of analgesia was significantly prolonged in both Group L (19.2 ± 2.6 h and Group H (21.3 ± 1.7 h compared with Group C (11.6 ± 1.1 h (p<0.05. Similarly, the duration of motor block was longer in both Group L (26.6 ± 2.8 h, and Group H (28.4 ± 2.2 h compared to Group C (18.6 ± 3.1 h (p<0.05. Postoperative analgesic consumption for the first 48 hours was significantly lower in Group L (6.5 [4–8] tabs and in Group H (5.5 [4–7] tabs vs. 9.5 [8–12] tabs in Group C (p<0.01. CONCLUSION: The addition of dexamethasone to levobupivacaine significantly prolonged the duration of the motor block and improved the quality of analgesia following interscalene block. There was no difference in the duration of analgesia and motor block between low-dose and high-dose dexamethasone.

  19. [μ2-Bis(diphenylphosphanylmethane][μ3-bis(diphenylphosphanylmethyl]trichloridotetragold(I tetrahydrofuran disolvate

    Directory of Open Access Journals (Sweden)

    Huan-Huan Wang

    2011-02-01

    Full Text Available The title tetranuclear complex, [Au4(C25H21P2Cl3(C25H22P2]·2C4H8O, features two non-equivalent Ph2PCPPh2 fragments, one of which represents the `complete' molecule (with two H atoms at the central C atom; each of the two P atoms of this molecule is coordinated by an Au atom [Au—P = 2.2256 (13 and 2.2710 (13 Å], and these two Au atoms form an Au—Au bond [3.2945 (3 Å], thus closing the five-membered Au2P2C ring. The first of these Au atoms has a terminal chlorido ligand [Au—Cl = 2.2806 (12 Å], whereas the second Au atom forms a covalent bond with the central C atom of the bis(diphenylphosphinomethyl group [Au—C = 2.114 (5 Å]; the latter group in turn coordinates with its P atoms the gold atoms of the Cl–Au–Au–Cl group [Au—P = 2.2356 (13 and 2.2338 (13, Au—Au = 3.3177 (3, Au—Cl = 2.3091 (12 and 2.2950 (13 Å], thus closing the second Au2P2C ring. The two such rings have different chemical functions, but both exhibit envelope conformations. However, the first (with different substituents at the Au atoms is non-symmetrical with one of the P atoms in the flap position of the envelope; the other one has a conformation with mirror symmetry, and the gold-substituted C atom is displaced by 0.740 (5 Å from the almost exactly planar (r.m.s. deviation = 0.0038 Å Au2P2 group.

  20. Photometric redshifts and clustering of emission line galaxies selected jointly by DES and eBOSS

    Energy Technology Data Exchange (ETDEWEB)

    Jouvel, S.; et al.

    2015-09-23

    We present the results of the first test plates of the extended Baryon Oscillation Spectroscopic Survey. This paper focuses on the emission line galaxies (ELG) population targetted from the Dark Energy Survey (DES) photometry. We analyse the success rate, efficiency, redshift distribution, and clustering properties of the targets. From the 9000 spectroscopic redshifts targetted, 4600 have been selected from the DES photometry. The total success rate for redshifts between 0.6 and 1.2 is 71\\% and 68\\% respectively for a bright and faint, on average more distant, samples including redshifts measured from a single strong emission line. We find a mean redshift of 0.8 and 0.87, with 15 and 13\\% of unknown redshifts respectively for the bright and faint samples. In the redshift range 0.6h < -21.0. We note that biasing is derived from the galaxy clustering relative to a model for the mass fluctuations. We investigate the quality of the DES photometric redshifts and find that the outlier fraction can be reduced using a comparison between template fitting and neural network, or using a random forest algorithm.

  1. Optimisation research of petroleum hydrocarbon biodegradation in weathered drilling wastes from waste pits.

    Science.gov (United States)

    Steliga, Teresa; Jakubowicz, Piotr; Kapusta, Piotr

    2010-12-01

    The aim of this article is to discuss the problem of drilling waste remediation. Analyses and research showed that material stored in waste pits could be classified as soil with a high level of petroleum impurities (total petroleum hydrocarbons [TPH] = 102,417-132,472 mg kg(-1) dry mass). While preparing the complex technology of soil decontamination (which included primary reclamation, basic bioremediation and inoculation with biopreparations based on indigenous bacteria and fungi), laboratory tests indicated the use of an ex-situ method was fundamental. Remediation was controlled with a chromatographic method of qualitative and quantitative determination of petroleum hydrocarbons. Based on analytical data, there was the possibility to determine the effectiveness of consecutive purifying phases. Laboratory tests, following 135 days of basic bioremediation stimulated by optimum conditions to activate the growth of indigenous micro-organisms, resulted in a decrease in the TPH content, which was in the range of 52.3-72.5%. The next phase of soil decontamination lasted 135 days and involved the use of inoculation with biopreparations based on indigenous micro-organisms and fungi. This process enabled a TPH decrease of 93.8- 94.3%. Laboratory biodegradation research was done with the use of the biomarker C30-17α(H)21β(H)-hopane to normalize analyte (TPH, Σn-C8-n-C22 and Σn-C23-n-C36) concentrations. The calculated first-order biodegradation constants enable estimation of the purification stage dynamics and the effectiveness of the applied biopreparations. Furthermore, they represent the biodegradation degree of individual n-alkanes in subsequent stages of the soil purification process.

  2. Studies on the hydrothermal modifications of new cocoyam (Xanthosoma sagittifolium) starch.

    Science.gov (United States)

    Lawal, Olayide S

    2005-12-30

    Native new cocoyam starch (nNCS) was subjected to annealing (aNCS) and heat moisture treatment at 18% moisture level (h18NCS), 21% moisture level (h21NCS), 24% moisture level (h24NCS) and 27% moisture level (h27NCS) as hydrothermal treatments. Scanning electron and light microscopy revealed round and polygonal shapes with sizes ranging from 15 to 40 microm for native and modified starches. nNCS showed "A" pattern X-ray diffraction and no significant differences were observed in the X-ray pattern of the modified starches. Swelling power and solubility reduced following heat moisture treatment. At all pH studied (2-12), unmodified new cocoyam starch exhibited higher swelling capacity and solubility than the modified derivatives. Hydrothermal modifications improved water absorption capacity but reduced oil absorption capacity. Pasting temperature of native starch shifted to higher values following annealing and heat moisture treatment. Hot paste viscosity (Hv), viscosity after 30 min holding at 95 degrees C (Hv30) and cold paste viscosity (Cv) reduced after annealing and heat moisture treatment. The result also indicates that hydrothermal treatments reduced the tendency for setback. As the number of days of storage of starch paste increased from 1 to 10, light transmittance of all the starches reduced but marked reduction of light transmittance was observed in native starch. DSC studies revealed increase in gelatinization temperature following annealing and heat moisture treatment. Starch hydrothermal modifications reduced retrogradation as enthalpies of regelatinization reduced following modifications. The regelatinization peak in the second day scanning shifted to lower temperature than the gelatinization peak in first run heating DSC curve for all samples. The regelatinization peak also became larger and shifted to higher temperature range when the storage days increased from 2 to 7.

  3. Crystal structures, lattice potential energies, and thermochemical properties of crystalline compounds (1-C(n)H(2n+1)NH3)2ZnCl4(s) (n = 8, 10, 12, and 13).

    Science.gov (United States)

    Liu, Yupu; Di, Youying; He, Donghua; Zhou, Qian; Dou, Jianmin

    2011-11-01

    As part of our ongoing project involving the study of (1-C(n)H(2n+1)NH(3))(2)MCl(4)(s) (where M is a divalent metal ion and n = 8-18), we have synthesized the compounds (1-C(n)H(2n+1)NH(3))(2)ZnCl(4)(s) (n = 8, 10, 12, and 13), and the details of the structures are reported herein. All of the compounds were crystallized in the monoclinic form with the space group P2(1)/n for (1-C(8)H(17)NH(3))(2)ZnCl(4)(s), P21/c for (1-C(10)H(21)NH(3))(2)ZnCl(4)(s), P2(1)/c for (1-C(12)H(25)NH(3))(2)ZnCl(4)(s), and P2(1)/m for (1-C(13)H(27)NH(3))(2)ZnCl(4)(s). The lattice potential energies and ionic volumes of the cations and the common anion of the title compounds were obtained from crystallographic data. Molar enthalpies of dissolution of the four compounds at various molalities were measured at 298.15 K in the double-distilled water. According to Pitzer's theory, molar enthalpies of dissolution of the title compounds at infinite dilution were obtained. Finally, using the values of molar enthalpies of dissolution at infinite dilution (Δ(s)H(m)(∞)) and other auxiliary thermodynamic data, the enthalpy change of the dissociation of [ZnCl(4)](2-)(g) for the reaction [ZnCl(4)](2-)(g)→ Zn(2+)(g) + 4Cl(-)(g) was obtained, and then the hydration enthalpies of cations were calculated by designing a thermochemical cycle.

  4. Different molecular conformations co-exist in each of three 2-aryl-N-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)acetamides: hydrogen bonding in zero, one and two dimensions.

    Science.gov (United States)

    Narayana, Badiadka; Yathirajan, Hemmige S; Rathore, Ravindranath S; Glidewell, Christopher

    2016-09-01

    4-Antipyrine [4-amino-1,5-dimethyl-2-phenyl-1H-pyrazol-3(2H)-one] and its derivatives exhibit a range of biological activities, including analgesic, antibacterial and anti-inflammatory, and new examples are always of potential interest and value. 2-(4-Chlorophenyl)-N-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)acetamide, C19H18ClN3O2, (I), crystallizes with Z' = 2 in the space group P\\overline{1}, whereas its positional isomer 2-(2-chlorophenyl)-N-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)acetamide, (II), crystallizes with Z' = 1 in the space group C2/c; the molecules of (II) are disordered over two sets of atomic sites having occupancies of 0.6020 (18) and 0.3980 (18). The two independent molecules of (I) adopt different molecular conformations, as do the two disorder components in (II), where the 2-chlorophenyl substituents adopt different orientations. The molecules of (I) are linked by a combination of N-H...O and C-H...O hydrogen bonds to form centrosymmetric four-molecule aggregates, while those of (II) are linked by the same types of hydrogen bonds forming sheets. The related compound N-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-2-(3-methoxyphenyl)acetamide, C20H21N3O3, (III), is isomorphous with (I) but not strictly isostructural; again the two independent molecules adopt different molecular conformations, and the molecules are linked by N-H...O and C-H...O hydrogen bonds to form ribbons. Comparisons are made with some related structures, indicating that a hydrogen-bonded R2(2)(10) ring is the common structural motif.

  5. An experimental study of adolescent sleep restriction during a simulated school week: changes in phase, sleep staging, performance and sleepiness.

    Science.gov (United States)

    Agostini, Alex; Carskadon, Mary A; Dorrian, Jillian; Coussens, Scott; Short, Michelle A

    2017-04-01

    This laboratory study investigated the impact of restricted sleep during a simulated school week on circadian phase, sleep stages and daytime functioning. Changes were examined across and within days and during a simulated weekend recovery. Participants were 12 healthy secondary school students (six male) aged 15-17 years [mean = 16.1 years, standard deviation (SD) = 0.9]. After 2 nights with 10 h (21:30-07:30 hours), time in bed was restricted to 5 h for 5 nights (02:30-07:30 hours), then returned to 10 h time in bed for 2 nights (21:30-07:30 hours). Saliva was collected in dim light on the first and last sleep restriction nights to measure melatonin onset phase. Sleep was recorded polysomnographically, and the Psychomotor Vigilance Task (PVT) and Karolinska Sleepiness Scale were undertaken 3-hourly while awake. Average phase delay measured by melatonin was 3 h (SD = 50 min). Compared to baseline, sleep during the restriction period contained a smaller percentage of Stages 1 and 2 and rapid eye movement (REM) and a greater percentage of Stage 4. PVT lapses increased significantly during sleep restriction and did not return to baseline levels during recovery. Subjective sleepiness showed a similar pattern during restriction, but returned to baseline levels during recovery. Results suggest that sustained attention in adolescents is affected negatively by sleep restriction, particularly in the early morning, and that a weekend of recovery sleep is insufficient to restore performance. The discrepancy between sleepiness ratings and performance may indicate a lack of perception of this residual impairment.

  6. Identification of Ganglioside GM3 Molecular Species in Human Serum Associated with Risk Factors of Metabolic Syndrome.

    Directory of Open Access Journals (Sweden)

    Lucas Veillon

    Full Text Available Serum GM3 molecular species were quantified in 125 Japanese residents using tandem mass spectrometry multiple reaction monitoring. Individuals were categorized by the presence or absence of metabolic disease risk factors including visceral fat accumulation, hyperglycemia and dyslipidemia. A total of 23 GM3 molecular species were measured, of these, eight were found to be significantly elevated in individuals with visceral fat accumulation and metabolic disease, defined as the presence of hyperglycemia and dyslipidemia. All of the GM3 molecular species were composed of the sphingoid base sphingosine (d18:1 (Δ4 and, interestingly, six of the eight elevated GM3 molecular species contained a hydroxylated ceramide moiety. The hydroxylated GM3 species were, in order of decreasing abundance, d18:1-h24:0 ≈ d18:1-h24:1 > d18:1-h22:0 » d18:1-h20:0 > d18:1-h21:0 > d18:1-h18:1. Univariate and multiple linear regression analyses were conducted using a number of clinical health variables associated with obesity, type 2 diabetes, metabolic disease, atherosclerosis and hypertension. GM3(d18:1-h24:1 was identified as the best candidate for metabolic screening, proving to be significantly correlated with intima-media thickness, used for the detection of atherosclerotic disease in humans, and a number of metabolic disease risk factors including autotaxin, LDL-c and homeostatic model assessment insulin resistance (HOMA-IR.

  7. ALMA Observations of Orion Source I at 350 and 660 GHz

    Science.gov (United States)

    Plambeck, R. L.; Wright, M. C. H.

    2016-12-01

    Orion Source I (“SrcI”) is the protostar at the center of the Kleinmann-Low Nebula. ALMA observations of SrcI with 0.″2 angular resolution were made at 350 and 660 GHz to search for the H26α and H21α hydrogen recombination lines and to measure the continuum flux densities. The recombination lines were not detected, ruling out the possibility that SrcI is a hypercompact H ii region. The deconvolved size of the continuum source is approximately 0.″23 × 0.″07 (˜100 × 30 au); it is interpreted as a disk viewed almost edge-on. Optically thick thermal emission from ˜500 K dust is the most plausible source of the continuum, even at frequencies as low as 43 GHz; the disk mass is most likely in the range 0.02-0.2 {M}⊙ . A rich spectrum of molecular lines is detected, mostly from sulfur- and silicon-rich molecules like SO, SO2, and SiS, but also including vibrationally excited CO and several unidentified transitions. Lines with upper energy levels {E}{{U}}\\gt 500 K appear in emission and are symmetric about the source’s LSR velocity of 5 {km} {{{s}}}-1, while lines with {E}{{U}}\\lt 500 K appear as blueshifted absorption features against the continuum, indicating that they originate in outflowing gas. The emission lines exhibit a velocity gradient along the major axis of the disk that is consistent with rotation around a 5-7 {M}⊙ central object. The relatively low mass of SrcI and the existence of a 100 au disk around it are difficult to reconcile with the model in which SrcI and the nearby Becklin-Neugebauer Object were ejected from a multiple system 500 years ago.

  8. Phylogenetic Analysis of Enteroaggregative Escherichia coli (EAEC) Isolates from Japan Reveals Emergence of CTX-M-14-Producing EAEC O25:H4 Clones Related to Sequence Type 131.

    Science.gov (United States)

    Imuta, Naoko; Ooka, Tadasuke; Seto, Kazuko; Kawahara, Ryuji; Koriyama, Toyoyasu; Kojyo, Tsuyoshi; Iguchi, Atsushi; Tokuda, Koichi; Kawamura, Hideki; Yoshiie, Kiyotaka; Ogura, Yoshitoshi; Hayashi, Tetsuya; Nishi, Junichiro

    2016-08-01

    Enteroaggregative Escherichia coli (EAEC) causes acute or persistent diarrhea. The aggR gene is widely used as a marker for typical EAEC. The heterogeneity of EAEC is well known; however, there are few reports on the phylogenetic relationships of EAEC. Recently, CTX-M extended-spectrum β-lactamase (ESBL)-producing EAEC strains have been reported worldwide. To characterize EAEC strains in Japan, we investigated the population structure of EAEC. A total of 167 aggR-positive strains isolated from stool specimens from diarrheal patients in Kagoshima (139 strains) and Osaka (28 strains), Japan, between 1992 and 2010 were examined for the prevalence of EAEC virulence markers, the blaCTX-M gene, and the capacity to form biofilms. Multilocus sequence typing was also conducted. EAEC strains were widely distributed across four major E. coli phylogroups. Strains of O111:H21/clonal group 40 (CG40) (30 strains), O126:H27/CG200 (13 strains), and O86a:H27/CG3570 (11 strains) in phylogroup B1 are the historical EAEC clones in Japan, and they exhibited strong biofilm formation. Twenty-nine strains of EAEC O25:H4/CG131 were identified in phylogroup B2, 79% of which produced CTX-M-14. This clone has emerged since 2003. The clone harbored plasmid-encoded EAEC virulence genes but not chromosomal virulence genes and had lower biofilm-forming capacity than historical EAEC strains. This clone most likely emerged from a pandemic uropathogenic O25:H4/sequence type 131 clone by acquiring an EAEC virulence plasmid from canonical EAEC. Surveillance of the horizontal transfer of both virulence and ESBL genes among E. coli strains is important for preventing a worldwide increase in antimicrobial drug resistance.

  9. Crystal structure of 2A proteinase from hand, foot and mouth disease virus.

    Science.gov (United States)

    Mu, Zhixia; Wang, Bei; Zhang, Xiaoyu; Gao, Xiaopan; Qin, Bo; Zhao, Zhendong; Cui, Sheng

    2013-11-15

    EV71 is responsible for several epidemics worldwide; however, the effective antiviral drug is unavailable to date. The 2A proteinase (2A(pro)) of EV71 presents a promising drug target due to its multiple roles in virus replication, inhibition of host protein synthesis and evasion of innate immunity. We determined the crystal structure of EV71 2A(pro) at 1.85Å resolution, revealing that the proteinase maintains a chymotrypsin-like fold. The active site is composed of the catalytic triads C110A, H21 and D39 with the geometry similar to that in other picornaviral 2A(pro), 3C(pro) and serine proteinases. The cI-to-eI2 loop at the N-terminal domain of EV71 2A(pro) adopts a highly stable conformation and contributes to the hydrophilic surface property, which are strikingly different in HRV2 2A(pro) but are similar in CVB4 2A(pro). We identified a hydrophobic motif "LLWL" followed by an acidic motif "DEE" at the C-terminus of EV71 2A(pro). The "LLWL" motif is folded into the β-turn structure that is essential for the positioning of the acidic motif. Our structural and mutagenesis study demonstrated that both the negative charging and the correct positioning of the C-terminus are essential for EV71 replication. Deletion of the "LLWL" motif abrogated the proteolytic activity, indicating that the motif is critical for maintaining the active proteinase conformation. Our findings provide the structural and functional insights into EV71 2A(pro) and establish a framework for structure-based inhibitor design.

  10. Recalcitrance and degradation of petroleum biomarkers upon abiotic and biotic natural weathering of Deepwater Horizon oil.

    Science.gov (United States)

    Aeppli, Christoph; Nelson, Robert K; Radović, Jagoš R; Carmichael, Catherine A; Valentine, David L; Reddy, Christopher M

    2014-06-17

    Petroleum biomarkers such as hopanoids, steranes, and triaromatic steroids (TAS) are commonly used to investigate the source and fate of petroleum hydrocarbons in the environment based on the premise that these compounds are resistant to biotic and abiotic degradation. To test the validity of this premise in the context of the Deepwater Horizon disaster, we investigated changes to these biomarkers as induced by natural weathering of crude oil discharged from the Macondo Well (MW). For surface slicks collected from May to June in 2010, and other oiled samples collected on beaches in the northern Gulf of Mexico from July 2010 until August 2012, hopanoids with up to 31 carbons as well as steranes and diasteranes were not systematically affected by weathering processes. In contrast, TAS and C32- to C35-homohopanes were depleted in all samples relative to 17α(H),21β(H)-hopane (C30-hopane). Compared to MW oil, C35-homohopanes and TAS were depleted by 18 ± 10% and 36 ± 20%, respectively, in surface slicks collected from May to June 2010, and by 37 ± 9% and 67 ± 10%, respectively, in samples collected along beaches from April 2011 through August 2012. Based on patterns of relative losses of individual compounds, we hypothesize biodegradation and photooxidation as main degradation processes for homohopanes and TAS, respectively. This study highlights that (i) TAS and homohopanes can be degraded within several years following an oil spill, (ii) the use of homohopanes and TAS for oil spill forensics must account for degradation, and (iii) these compounds provide a window to parse biodegradation and photooxidation during advanced stages of oil weathering.

  11. Biological marker distribution and significance in oils and rocks of the Monterey Formation, California

    Science.gov (United States)

    Curiale, Joseph A.; Cameron, Douglas; Davis, Dean V.

    1985-01-01

    The biological marker distributions of several oils, core extracts and solid bitumens of the Monterey Formation of California have been studied. Sterane, terpane and monoaromatic steroid hydrocarbons were analyzed in samples from the San Joaquin, Los Angeles, Ventura and Santa Maria Basins. The sterane patterns of both oils and extracts are characterized by (a) low relative concentrations of diasteranes, (b) low 20S/20R-5α,14α,17α-ethylcholestane ratios, (c) relatively high concentrations of cholestane ( vs. methyl- and ethylcholestane) isomers. San Joaquin Basin samples contain significant amounts of the 5β isomer, which is generally absent in samples from other basins. The carbon number distribution of 5α,14α,17α,20R steranes is similar for all oils, regardless of API gravity, depth or basin location, and is suggestive of open marine depositional conditions for the source material involved. 17α(H),l8α(H),21β(H)-28,30-Bisnorhopane is present in almost all samples. Certain San Joaquin Basin oils and extracts contain (a) a series of 25-nor hopanes, including 25,28,30-trisnorhopane, (b) a distinctive monoaromatic steroid hydrocarbon distribution, (c) an aliphatic hydrocarbon fraction devoid of n-paraffins. Biological marker characteristics suggest that the Monterey oils examined originated early in the maturational sequence, from elastics-poor source material. API gravities of the Monterey Formation oils examined vary monotonically with (a) bisnorhopane/hopane ratios, (b) aromatized/regular sterane ratios and (c) the concentration of monoaromatized steranes relative to terpanes and regular steranes. These oil gravity correlations exist regardless of sample depth or basin location.

  12. The Effect of Transdermal Scopolamine for the Prevention of Postoperative Nausea and Vomiting

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    Maria A. Antor

    2014-04-01

    Full Text Available Postoperative nausea and vomiting is one of the most common and undesirable complaints recorded in as many as 70%-80% of high-risk surgical patients. The current prophylactic therapy recommendations for PONV management stated in the Society of Ambulatory Anesthesia guidelines should start with monotherapy and patients at moderate to high risk, a combination of antiemetic medication should be considered. Consequently, if rescue medication is required, the antiemetic drug chosen should be from a different therapeutic class and administration mode than the drug used for prophylaxis. The guidelines restrict the use of dexamethasone, transdermal scopolamine, aprepitant, and palonosetron as rescue medication 6 hours after surgery. In an effort to find a safer and reliable therapy for postoperative nausea and vomiting, new drugs with antiemetic properties and minimal side effects are needed, and scopolamine may be considered an effective alternative. Scopolamine is a belladonna alkaloid, α-(hydroxymethyl benzene acetic acid 9-methyl-3-oxa-9-azatricyclo non-7-yl ester, acting as a nonselective muscarinic antagonist and producing both peripheral antimuscarinic and central sedative, antiemetic, and amnestic effects. The empirical formula is C17H21NO4 and its structural formula is a tertiary amine L-(2-scopolamine (tropic acid ester with scopine; MW = 303.4. Scopolamine became the first drug commercially available as a transdermal therapeutic system used for extended continuous drug delivery during 72 hours. Clinical trials with transdermal scopolamine have consistently demonstrated its safety and efficacy in postoperative nausea and vomiting. Thus, scopolamine is a promising candidate for the management of postoperative nausea and vomiting in adults as a first line monotherapy or in combination with other drugs. In addition, transdermal scopolamine might be helpful in preventing postoperative discharge nausea and vomiting owing to its long

  13. A comparative haematological analysis of Asian Elephants Elephas maximus Linnaeus, 1758 (Mammalia: Proboscidea: Elephantidae managed under different captive conditions in Sri Lanka

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    R.K.D. Mel

    2014-07-01

    Full Text Available Haematological parameters were assessed from elephants of three institutions in Sri Lanka with different captive conditions, in order to evaluate if different captive conditions influence the physiology of the animals. The institutions were: The National Zoological Gardens (NZG, where elephants live a comparatively sedentary lifestyle, Pinnawala Elephant Orphanage (PEO, where elephants are allowed to walk and engage in intra-specific behaviours, and Millennium Elephant Foundation (MEF, where the elephants are used for tourist rides. Four adult females were examined from the NZG, while only two males and two females could be examined from PEO and MEF respectively. All animals were sampled on four consecutive days. Blood glucose levels, total white blood cells (WBC, red blood cells (RBC, packed cell volume (PCV, mean corpuscular volume (MCV and differential white blood cell counts were carried out. Certain blood parameters of the elephants from NZG differed significantly from the parameters of the elephants from PEO and MEF. These were, the total WBC counts (Kruskal-Wallis, H=21.92, 2d.f., P=0.000, the lymphocyte count (Kruskal-Wallis, H=16.40, 2d.f., P=0.00 and the Neutrophil: Lymphocyte ratios (Kruskal-Wallis , H=14.58, 2d.f., P less than 0.05. PCV , blood glucose levels and monocyte counts were also shown to be significantly different among the three groups (Kruskal-Wallis P less than 0.000. We suggest that differences in the stress levels associated with the different management methods might influence these haematological values.

  14. High indium content graded channel GainAs/AlinAs pseudomorphic MODFETs

    Science.gov (United States)

    Laskar, J.; Kolodzey, J.; Boor, S.; Hsieh, K. C.; Kalem, S.; Caracci, S.; Ketterson, A. A.; Brock, T.; Adesida, I.; Sivco, D.; Cho, A. Y.

    1990-03-01

    We report on the electrical and microstructural properties of InP/GaxIn 1 -xAs/Al0.48In0.52As modulation doped layers having compositionally graded active channels with different channel thicknesses. The layers were grown by solid source molecular beam epitaxy on Fe-doped InP substrates. The undoped GaInAs two dimensional electron gas channel layers were grown having indium compositions graded from x = 0.53 at the substrate buffer to x= 0.65 at the heterointerface by varying the Ga cell temperature during growth. Active channel thicknesses of 20 nm and 30 nm were compared with lattice matched layers. Transmission electron microscope image analysis indicates no misfit dislocations in these structures. Hall-effect measurements at 300 K show an increase in the mobility from 8,380 cm2/Vs for the lattice matched layer to 12,500 cm2/Vs for the 30 nm pseudomorphic layer. Small gate-length, 0.25 μn, MODFETs were fabricated to determine effective velocity values from transconductance ( g m ) and current gain ( h 21 ) measurements. The peak dc extrinsic g m increased from 367 mS/mm for the lattice matched layer to 668 mS/mm for the 30 nm pseudomorphic layer. The effective electron carrier velocity increased from 1.57 × 107 cm/s for the lattice matched layer to 1.88 × 107 cm/s for the 30 nm pseudomorphic layer. Our results show that compositional grading is a useful technique to obtain thick pseudomorphic layers with good transport properties.

  15. Unveiling the Milky Way: A New Technique for Determining the Optical Color and Luminosity of Our Galaxy

    Science.gov (United States)

    Licquia, Timothy C.; Newman, Jeffrey A.; Brinchmann, Jarle

    2015-08-01

    We demonstrate a new statistical method of determining the global photometric properties of the Milky Way (MW) to an unprecedented degree of accuracy, allowing our Galaxy to be compared directly to objects measured in extragalactic surveys. Capitalizing on the high-quality imaging and spectroscopy data set from the Sloan Digital Sky Survey (SDSS), we exploit the inherent dependence of galaxies’ luminosities and colors on their total stellar mass, {{{M}}}\\star , and star formation rate (SFR), {\\dot{{{M}}}}\\star , by selecting a sample of Milky Way analog galaxies designed to reproduce the best Galactic {{{M}}}\\star and {\\dot{{{M}}}}\\star measurements, including all measurement uncertainties. Making the Copernican assumption that the MW is not extraordinary among galaxies of similar stellar mass and SFR, we then analyze the photometric properties of this matched sample, constraining the characteristics of our Galaxy without suffering interference from interstellar dust. We explore a variety of potential systematic errors that could affect this method, and find that they are subdominant to random uncertainties. We present both SDSS ugriz absolute magnitudes and colors in both rest-frame z = 0 and z = 0.1 passbands for the MW, which are in agreement with previous estimates but can have up to ˜3× lower errors. We find the MW to have absolute magnitude {}0{M}r-5{log}h=-{21.00}-0.37+0.38 and integrated color {}0(g-r)={0.682}-0.056+0.066, indicating that it may belong to the green-valley region in color-magnitude space and ranking it among the brightest and reddest of spiral galaxies. We also present new estimates of global stellar mass-to-light ratios for our Galaxy. This work will help relate our in-depth understanding of the Galaxy to studies of more distant objects.

  16. η Carinae Baby Homunculus uncovered by ALMA

    Energy Technology Data Exchange (ETDEWEB)

    Abraham, Zulema; Beaklini, Pedro P. B. [Instituto de Astronomia, Geofísica e Ciências Atmosféricas, Universidade de São Paulo, R. do Matão 1226, Cidade Universitária, CEP 05508-900 São Paulo, SP (Brazil); Falceta-Gonçalves, Diego, E-mail: zulema.abraham@iag.usp.br [Escola de Artes, Ciências e Humanidades, Universidade de São Paulo, R. Arlindo Bettio 1000, 03828-000 São Paulo, SP (Brazil)

    2014-08-20

    We report observations of η Carinae obtained with ALMA in the continuum of 100, 230, 280, and 660 GHz in 2012 November, with a resolution that varied from 2.''88 to 0.''45 for the lower and higher frequencies, respectively. The source is not resolved, even at the highest frequency; its spectrum is characteristic of thermal bremsstrahlung of a compact source, but different from the spectrum of optically thin wind. The recombination lines H42α, He42α, H40α, He40α, H50β, H28α, He28α, H21α, and He21α were also detected, and their intensities reveal non-local thermodynamic equilibrium effects. We found that the line profiles could only be fit by an expanding shell of dense and ionized gas, which produces a slow shock in the surroundings of η Carinae. Combined with fittings to the continuum, we were able to constrain the shell size, radius, density, temperature, and velocity. The detection of the He recombination lines is compatible with the high-temperature gas and requires a high-energy ionizing photon flux, which must be provided by the companion star. The mass-loss rate and wind velocity, necessary to explain the formation of the shell, are compatible with an luminous blue variable eruption. The position, velocity, and physical parameters of the shell coincide with those of the Weigelt blobs. The dynamics found for the expanding shell correspond to matter ejected by η Carinae in 1941 in an event similar to that which formed the Little Homunculus; for that reason, we called the new ejecta the 'Baby Homunculus'.

  17. HYDRA VULGARIS PALLAS, 1766 (HYDROZOA: HYDRIDAE AS BIOINDICATOR OF THE WATER QUALITY OF THE RIVER CHILI, AREQUIPA, PERU

    Directory of Open Access Journals (Sweden)

    Ronald Huarachi

    2012-12-01

    Full Text Available The aim of this study was to use Hydra vulgaris Pallas, 1766 (Hydrozoa: Hydridae as a bioindicator of water quality of the Chili River, Arequipa, Peru. The freshwater hydra were collected in the spring "Ojo del Milagro", Characato District, Arequipa, Peru. H. vulgaris was cultivated under standardized conditions and were fed Artemia sp. K2Cr2O7 was used as a positive control and as a reference toxin. Acute toxicity and morphological changes of H. vulgaris were evaluated on Tiabaya and Tingo, sampling points of the Chili River. The LC50 (median lethal concentration showed: Tingo (LC50-96h = 135.95% classifying it as non-toxic and Tiabaya (LC50 -24h = 61.83%, classifying it as moderately toxic; LC50-48h = 44.19% and LC50 -72h = 38.28% classifying them as toxic; LC50 -96h = 21.44% rating it as very toxic. Significant differences in the morphological changes of H. vulgaris were observed with regard to different concentrations and exposure time in waters sampled from Tingo from 48 h to 96 h and in Tiabaya, significant differences in morphological changes from 24 h to 96 h exposure. The results of the physicochemical parameters of the Chili River were compared with the Peruvian National Standards for Environmental Quality (ECA for water (categories 3 and 4 and recorded high values of biochemical oxygen demand BOD5, NH4 and PO4, and low dissolved oxigen OD values for Tiabaya. In Tingo, NH4 and phosphate were high. In Tiabaya, water was considered more toxic than at Tingo.

  18. Syntheses, Crystal Structures and Fluorescent Properties of Two New Imidazolidino Schiff Base Compounds

    Institute of Scientific and Technical Information of China (English)

    FENG Yue; LIU Gang; TIAN Xiu-Mei; WANG Ji-De; WANG Wei

    2008-01-01

    Two new imidazolidino Schiff base compounds, (E)-N-((quinoxalin-2-yl)methylene)-2-(2-(quinoxalin-3-yl)imidazolidin-1-yl)ethanamine 1 and 2-(1-(2-(2-(quinoxalin-3-yl)imidazolidin-1-yl)ethyl)imidazolidin-2-yl)quinoxaline 2, have been synthesized and characterized by elemental analysis,1H NMR, IR, MS and single-crystal X-ray diffraction. Crystallographic data for 1: C22H21N7,Mr = 383.46, monoclinic, space group P21, a = 7.0036(14), b=6.9151(14), c=19.701(4)(A),β=96.57(3)°, Z = 2, V=947.9(3)(A)3, Dc = 1.344 g/cm3, F(000)=404, μ = 0.085 mm-1, Flack parameter =0(2), R = 0.0464 and wR = 0.1055; and those for 2: C24H26N8, Mr = 426.53, triclinic, space group P(1),a = 9.6680(19), b = 10.334(2), c = 11.389(2)(A),α= 104.12(3),β= 102.95(3),γ= 100.48(3)°, Z=2,V=1041.2(4)(A)3, Dc=1.361 g/cm3, F(000) = 452,μ = 0.086 mm-1, R = 0.0373 and wR = 0.1155. For the two compounds, the five-membered imidazolidine rings all adopt envelope conformation.Moreover, the title compounds show one-dimensional layered and three-dimensional supramolecular chainlike structures, respectively. Fluorescent properties of the two compounds have been investigated in the solid state at room temperature. Compound 1 exhibits strong fluorescence and thus may serve as excellent candidates of green fluorescent materials.

  19. An extreme mountain ultra-marathon decreases the cost of uphill walking and running

    Directory of Open Access Journals (Sweden)

    Gianluca Vernillo

    2016-11-01

    Full Text Available Purpose: To examine the effects of the world’s most challenging mountain ultramarathon (MUM, 330 km, cumulative elevation gain of +24000 m on the energy cost and kinematics of different uphill gaits. Methods: Before (PRE and immediately after (POST the competition, 19 male athletes performed three submaximal 5-min treadmill exercise trials in a randomized order: walking at 5 km·h-1, +20%; running at 6 km·h-1, +15%; and running at 8 km·h-1, +10%. During the three trials, energy cost was assessed using an indirect calorimetry system and spatiotemporal gait parameters were acquired with a floor-level high-density photoelectric cells system. Results: The average time of the study participants to complete the MUM was 129 h 43 min 48 s (range: 107 h 29 min 24 s to 144 h 21 min 0 s. Energy costs in walking (-11.5 ± 5.5%, P < 0.001, as well as in the first (-7.2 ± 3.1%, P = 0.01 and second (-7.0 ± 3.9%, P = 0.02 running condition decreased between PRE and POST, with a reduction both in the heart rate (-11.3%, -10.0%, and -9.3%, respectively and oxygen uptake only for the walking condition (-6.5%. No consistent and significant changes in the kinematics variables were detected (P values from 0.10 to 0.96. Conclusion: Though fatigued after completing the MUM, the subjects were still able to maintain their uphill locomotion patterns noted at PRE. The decrease (improvement in the energy costs was likely due to the prolonged and repetitive walking/running, reflecting a generic improvement in the mechanical efficiency of locomotion after ~130 h of uphill locomotion rather than constraints imposed by the activity on the musculoskeletal structure and function.

  20. An Extreme Mountain Ultra-Marathon Decreases the Cost of Uphill Walking and Running.

    Science.gov (United States)

    Vernillo, Gianluca; Savoldelli, Aldo; Skafidas, Spyros; Zignoli, Andrea; La Torre, Antonio; Pellegrini, Barbara; Giardini, Guido; Trabucchi, Pietro; Millet, Grégoire P; Schena, Federico

    2016-01-01

    Purpose: To examine the effects of the world's most challenging mountain ultramarathon (MUM, 330 km, cumulative elevation gain of +24,000 m) on the energy cost and kinematics of different uphill gaits. Methods: Before (PRE) and immediately after (POST) the competition, 19 male athletes performed three submaximal 5-min treadmill exercise trials in a randomized order: walking at 5 km·h(-1), +20%; running at 6 km·h(-1), +15%; and running at 8 km·h(-1), +10%. During the three trials, energy cost was assessed using an indirect calorimetry system and spatiotemporal gait parameters were acquired with a floor-level high-density photoelectric cells system. Results: The average time of the study participants to complete the MUM was 129 h 43 min 48 s (range: 107 h 29 min 24 s to 144 h 21 min 0 s). Energy costs in walking (-11.5 ± 5.5%, P running condition decreased between PRE and POST, with a reduction both in the heart rate (-11.3, -10.0, and -9.3%, respectively) and oxygen uptake only for the walking condition (-6.5%). No consistent and significant changes in the kinematics variables were detected (P-values from 0.10 to 0.96). Conclusion: Though fatigued after completing the MUM, the subjects were still able to maintain their uphill locomotion patterns noted at PRE. The decrease (improvement) in the energy costs was likely due to the prolonged and repetitive walking/running, reflecting a generic improvement in the mechanical efficiency of locomotion after ~130 h of uphill locomotion rather than constraints imposed by the activity on the musculoskeletal structure and function.

  1. Topological data analysis of Escherichia coli O157:H7 and non-O157 survival in soils.

    Science.gov (United States)

    Ibekwe, Abasiofiok M; Ma, Jincai; Crowley, David E; Yang, Ching-Hong; Johnson, Alexis M; Petrossian, Tanya C; Lum, Pek Y

    2014-01-01

    Shiga toxin-producing E. coli O157:H7 and non-O157 have been implicated in many foodborne illnesses caused by the consumption of contaminated fresh produce. However, data on their persistence in soils are limited due to the complexity in datasets generated from different environmental variables and bacterial taxa. There is a continuing need to distinguish the various environmental variables and different bacterial groups to understand the relationships among these factors and the pathogen survival. Using an approach called Topological Data Analysis (TDA); we reconstructed the relationship structure of E. coli O157 and non-O157 survival in 32 soils (16 organic and 16 conventionally managed soils) from California (CA) and Arizona (AZ) with a multi-resolution output. In our study, we took a community approach based on total soil microbiome to study community level survival and examining the network of the community as a whole and the relationship between its topology and biological processes. TDA produces a geometric representation of complex data sets. Network analysis showed that Shiga toxin negative strain E. coli O157:H7 4554 survived significantly longer in comparison to E. coli O157:H7 EDL 933, while the survival time of E. coli O157:NM was comparable to that of E. coli O157:H7 EDL 933 in all of the tested soils. Two non-O157 strains, E. coli O26:H11 and E. coli O103:H2 survived much longer than E. coli O91:H21 and the three strains of E. coli O157. We show that there are complex interactions between E. coli strain survival, microbial community structures, and soil parameters.

  2. An Experimental Field Dataset with Buoyant, Neutral, and Dense Gas Atmospheric Releases and Model Comparisons in Low-Wind Speed (Diffusion) Conditions

    Energy Technology Data Exchange (ETDEWEB)

    Veronica E. Wannberg, Gustavious Williams, Patrick Sawyer, and Richard Venedam

    2010-09-01

    Aunique field dataset from a series of low–wind speed experiments, modeling efforts using three commonly used models to replicate these releases, and statistical analysis of how well these models were able to predict the plume concentrations is presented. The experiment was designed to generate a dataset to describe the behavior of gaseous plumes under low-wind conditions and the ability of current, commonly used models to predict these movements. The dataset documents the release and transport of three gases: ammonia (buoyant), ethylene (neutral), and propylene (dense) in low–wind speed (diffusion) conditions. Release rates ranged from 1 to 20 kg h21. Ammonia and ethylene had five 5-min releases each to represent puff releases and five 20-min releases each to represent plume releases. Propylene had five 5-min puffs, six 20-min plumes, and a single 30-min plume. Thirty-two separate releases ranging from 6 to 47 min were conducted, of which only 30 releases generated useful data. The data collected included release rates, atmospheric concentrations to 100 m from the release point, and local meteorological conditions. The diagnostics included nine meteorological stations on 100-m centers and 36 photoionization detectors in a radial pattern. Three current stateof- the-practice models, Aerial locations of Hazardous Atmospheres (ALOHA), Emergency Prediction Information code (EPIcode), and Second-Order Closure Integrated Puff (SCIPUFF), were used to try to duplicate the measured field results. Low wind speeds are difficult to model, and all of the models had difficulty replicating the field measurements. However, the work does show that these models, if used correctly, are conservative (overpredict concentrations) and can be used for safety and emergency planning.

  3. Differential Expression of Three Hypoxia-inducible Factor-α Subunits in Pulmonary Arteries of Rat with Hypoxia-induced Hypertension

    Institute of Scientific and Technical Information of China (English)

    Qi-Fang LI; Ai-Guo DAI

    2005-01-01

    Hypoxia inducible transcription factor (HIF)-1α plays an important role in the development of hypoxic pulmonary hypertension, but little is known about HIF-2α and HIF-3α with respect to transcriptional regulation by hypoxia. To examine the expression patterns of all HIF-α subunits (HIF-1α, HIF-2α and HIF-3α) in pulmonary arteries of rats undergoing systemic hypoxia, five groups of healthy male Wistar rats were exposed to normoxia (N) and hypoxia for 3 (H3), 7 (H7), 14 (H14) and 21 (H21) d respectively. Mean pulmonary arterial pressure (mPAP), vessel morphometry and right ventricular hypertrophy index were measured. Lungs were inflation fixed for immunohistochemistry and in situ hybridization, and homogenized for Western blot. mPAP increased significantly after 7 d of hypoxia [(18.4±0.4) vs. (14.4±0.4) mmHg, H7 vs.N], reached its peak after 14 d of hypoxia, then remained stable. Pulmonary artery remodeling and right ventricular hypertrophy developed significantly after 14 d of hypoxia. During normoxia, HIF-1 α and HIF-3α staining were slightly positive regarding mRNA levels. A substantial alteration of HIF-1 α and HIF-3α staining occurred in pulmonary arteries after 14 d and 7 d of hypoxia, respectively, but HIF-2α stainin g showed an inversed trend after 14 d of hypoxia. Protein levels of all HIF-α subunits except HIF-3α showed a marked increase corresponding to the duration of hypoxia, which was obtained by Western blot. Our study found that HIF-1 α, HIF-2α and HIF-3α may not only confer different target genes, but also play key pathogenetic roles in hypoxic-induced pulmonary hypertension.

  4. AD-MSCs alleviate hyperglycemia through promoting hepatic glycolysis in type 2 diabetic rats

    Directory of Open Access Journals (Sweden)

    Min XIE

    2016-08-01

    Full Text Available Objective  To evaluate the temporary hypoglycemic effect of adipose mesenchymal stem cells (AD-MSCs on type 2 diabetic rats, and further discuss the mechanisms of AD-MSCs regulating blood glucose through hepatic glycometabolism. Methods  The type 2 diabetic rat model was established by intraperitoneal injection of a single small dose of streptozotocin (STZ, 25mg/kg after a high-fat diet for 8 weeks. The content of blood glucose was determined by tail vein bleeding at indicated time points (0h, 3h, 6h, 12h, 24h after infusion of AD-MSCs, concurrently the rats were executed and the liver tissues were collected (diabetes group, n=5, normal group, n=3 for detecting the mRNA and protein expressions of glucokinase (GK, pyruvate kinase (PK and phosphofructokinase (PFK (the key enzyme of glycolysis by real-time qPCR and Western blotting. Results  The infusion of AD-MSCs significantly decreased blood glucose in a short period [30.55±1.49mmol/L(0h, 18.90±0.85mmol/ L(3h, 23.70±1.13mmol/L(6h, 21.90±1.00mmol/L(12h, respectively]. PCR results showed that the expressions of GK and PFK increased in the liver tissue of type 2 diabetic rats 3h after AD-MSCs infusion, and the expression of PK increased significantly 6h after AD-MSCs infusion (P<0.05. Conclusion  AD-MSCs can ameliorate hyperglycemia rapidly through enhancing liver glycolysis in type 2 diabetic rats. DOI: 10.11855/j.issn.0577-7402.2016.07.04

  5. Synthesis and Crystal Structure of Rctt-1-(2-benzoxazolyl)-2-(4-chlorophenyl)-4-phenyl-3-(4-pyridinyl) cyclobutane

    Institute of Scientific and Technical Information of China (English)

    庄俊鹏; 张文勤

    2003-01-01

    The title compound (C28H21ClN2O, Mr = 436.92) was synthesized by the cross- photodimerization of (E)-2-(2-phenylethenyl)benzoxazole and (E)-4-[2-(4-chlorophenyl)ethenyl]- pyridine in sulfuric acid solution. Its molecular structure has been unequivocally determined by X-ray crystallography. The title compound belongs to triclinic system, space group Pī with cell parameters: a = 9.648(3), b = 10.458(4), c = 12.106(4) A。, r = 89.089(7), a = 75.644(6), B = 68.441(7)o, V = 1096.7(7) A。3, Z = 2, Dc = 1.323 g/cm3, F(000) = 456 and ((MoKa) = 0.198 mm-1. The final R and wR are 0.0627 and 0.1285, respectively for 1737 observed reflections with I > 2((I). S = 0.921 and (Δ/max = 0.001. The cyclobutane ring has a puckered conformation with four different aryl groups substituted on each carbon atom. The dihedral angles of the cyclobutane ring are 20.2 and 20.6o. The bond distances of the cyclobutane ring are 1.541, 1.555, 1.560 and 1.563 A。, respectively, which are slightly longer than that of the normal C-C single bond. The title compound is the only cross-dimer and its two heteroaryl groups are situated at the trans-1,3 position of the cyclobutane ring, revealing that the cross-photodimerization proceeds in a head-to-tail pattern with high stereo-selectivity.

  6. Synthesis and Crystal Structure of Rctt—1—(2—benzoxaolyl)—2—(4—chlorophenyl)—4—phenyl—3—(4—pyridinyl)cyclobutane

    Institute of Scientific and Technical Information of China (English)

    ZHUANGJun-Peng; ZHANGWen-Qin

    2003-01-01

    The title compound (C28H21C1N2O,Mr=436.92) was synthesized by the cross-photodimerization of (E)-2-(2-phenylethenyl) benzoxazole and (E)-4-[2-(4-cholrophenyl)ethenyl]-pyridine in sulfuric acid solution.Its molecular structure has been unequivocally detemined by X-ray Crystallography,The title compound belongs to triclinic system,space group P-↑1 with cell parameters:a=9.648(3),b=0.458(4),c=12.1064(4)°↑A,α=89.089(7),β=75.644(6),γ=68.441(7)°,V=1096.7(7)°↑A3,Z=2,Dc=1.323 g/cm3,F(000)=456 and μ(Mokα)=0.198mm-1,The final R and wR are 0.0627 and 0.1285,respectively for 1737 observed refections with I>2σ(I),S=0.921 and (△/σ)max=0.001,The cyclobutane ring has a puckered conformation with four different aryl groups substituted on each carbon atom.The dihedral angles of the cyclobutane ring are 20.2 and 20.6°.The bond distances of the cyclobutane ring are 1.541,1.555,1.560 and 1.563°↑A,respectively,which are slightly longer than that of the normal C-C single bond.The title compound is the only cross-dimer and its two heteroaryl groups are situated at the trans-1,3 position of the cyclobutane ring,revealing that the cross-photodimerization proceeds in a head-to-tail pattern with high stereo-selectivity.

  7. P-glycoprotein senses its substrates and the lateral membrane packing density: consequences for the catalytic cycle.

    Science.gov (United States)

    Aänismaa, Päivi; Gatlik-Landwojtowicz, Ewa; Seelig, Anna

    2008-09-23

    P-glycoprotein (ABCB1) prevents absorption (e.g., blood-brain barrier) or enhances excretion (e.g., kidney) by moving substrates from the cytosolic to the extracellular membrane leaflet at the expense of ATP hydrolysis. It translocates various drugs and functions in membranes exhibiting different lateral packing densities. To gain more functional insight, we measured the temperature dependence of the P-glycoprotein ATPase activity in NIH-MDR1-G185 cell membranes in the absence and presence of three drugs (promazine, verapamil, and PSC833), exhibiting significantly different transporter affinities. Activation enthalpies (Delta H(++)) and entropies ( TDelta S(++)) were derived from Eyring plots. In the absence of drugs, the activation enthalpy and the free energy of activation for P-glycoprotein ATPase activity was determined as Delta H(++) = 92.6 +/- 4.2 kJ/mol and Delta G(++) = 73.1 +/- 7.2 kJ/mol, respectively. Increasing the drug concentration reduced the activation enthalpy, whereby the drug with the highest transporter affinity had the strongest effect (DeltaDelta H(++) = -21%). The free energy of activation decreased for activating (DeltaDelta G(++) = approximately -3.8%) and increased for inhibitory compounds (DeltaDelta G(++) = approximately +0.7%). The drug-specific changes of the free energy of activation are thus barely above thermal energy. A comparison with literature data revealed that a decrease of the lateral membrane packing density reduces the enthalpic and the entropic contribution to the free energy of activation. Although the P-glycoprotein ATPase activity increases only slightly with decreasing lateral membrane packing density, the mode of action changes from strongly entropy-driven at high, to essentially enthalpy-driven at low packing densities. This suggests that the transporter and the membrane form a functional entity.

  8. Deposition and Biodegradation of Submerged Oil from the Deepwater Horizon

    Science.gov (United States)

    Bagby, S. C.; Fisher, G. B.; Reddy, C. M.; Valentine, D. L.

    2014-12-01

    The 2010 sinking of the Deepwater Horizon in the Gulf of Mexico caused the release of ~5 million barrels of oil to the deep ocean. Roughly half of this oil, ~2 million barrels, is believed to have been trapped ~1000-1300 m deep in the water column, in plumes comprising water-soluble hydrocarbons in the aqueous phase and water-insoluble oil particles in suspension. While the soluble fraction was subject to rapid biodegradation, the fate of the oil particles has remained unknown. Using 17α(H),21β(H)-hopane (hopane) as a conservative marker of water-insoluble crude oil, we have examined the sediment data collected in support of the Natural Resource Damage Assessment process and identified a 3200-km2 depositional footprint surrounding the Macondo well. Under conservative assumptions, we estimate that this footprint accounts for ~12% of the suspended liquid oil. Monte Carlo modeling of the distribution of surficial hopane concentrations provides an initial estimate of the size distribution and spatial density of deposited particles, and suggests that the local spatial heterogeneity of particle deposition is likely to be extremely high, such that low-density sediment sampling is unlikely to capture the true extent of deposition. Thus, the 'missing' oil may be hiding in plain sight. Finally, we examined the spatial and temporal concentration distribution of >100 hydrocarbon compounds in relation to hopane, finding that, while there is clear evidence for biodegradation of many compounds, biodegradative efficiency appears to be impeded by high concentrations of oil, perhaps reflecting the low surface area to volume ratio of large oil particles.

  9. Hopane, sterane and n-alkane distributions in shallow sediments hosting high arsenic groundwaters in Cambodia

    Energy Technology Data Exchange (ETDEWEB)

    Dongen, Bart E. van [School of Earth, Atmospheric and Environmental Sciences, Williamson Research Centre for Molecular Environmental Science, University of Manchester, Oxford Road, Manchester M13 9PL (United Kingdom)], E-mail: Bart.vanDongen@manchester.ac.uk; Rowland, Helen A.L.; Gault, Andrew G.; Polya, David A. [School of Earth, Atmospheric and Environmental Sciences, Williamson Research Centre for Molecular Environmental Science, University of Manchester, Oxford Road, Manchester M13 9PL (United Kingdom); Bryant, Charlotte [NERC Radiocarbon Laboratory, Scottish Enterprise Technology Park, Rankine Avenue, East Kilbride G75 0QF (United Kingdom); Pancost, Richard D. [Organic Geochemistry Unit, Bristol Biogeochemistry Research Centre, School of Chemistry, Cantock' s Close, Bristol University, Bristol BS8 1TS (United Kingdom)

    2008-11-15

    The presence of elevated As in ground waters exploited for drinking water and irrigation in South-East Asia is causing serious impacts on human health. A key mechanism that causes the mobilization of As in these waters is microbially mediated reductive transformation of As-bearing Fe(III) hydrated oxides and the role of degradable organic matter (OM) in this process is widely recognized. A number of different types of OM that drive As release in these aquifers have been suggested, including petroleum derived hydrocarbons naturally seeping into shallow sediments from deeper thermally mature source rocks. However, the amount of information on the characteristics of the OM in South-East Asian aquifers is limited. Here the organic geochemical analyses of the saturated hydrocarbon fractions and radiocarbon analysis, of two additional sites in SE Asia are reported. The results show that the OM in a given sedimentary horizon likely derives from multiple sources including naturally occurring petroleum. The importance of naturally occurring petroleum as one of the sources was clearly indicated by the n-alkane CPI of approximately 1, the presence of an unresolved complex mixture, and hopane (dominated by 17{alpha}(H),21{beta}(H) hopanes) and sterane distribution patterns. The results also indicate that the OM in these aquifers varies tremendously in content, character and potential bioavailability. Furthermore, the presence of petroleum derived OM in sediments at both sites doubles the number of locations where their presence has been observed in association with As-rich, shallow aquifers, suggesting that the role of petroleum derived OM in microbially mediated As release might occur over a wider range of geographical locations than previously thought.

  10. An Unprecedented 2D 4f-3d-5d Multimetal-lsonicotinic Acid Complex: Synthesis, Structural Characterization and Magnetic Properties

    Institute of Scientific and Technical Information of China (English)

    CHEN Wen-Tong; ZENG Xi-Rui; LIU Dong-Sheng; YING Shao-Ming; LIU Jiu-Hui

    2008-01-01

    A novel heterometallic metal-isonicotinic acid inorganic-organic hybrid complex [Zno.5(H2O)]{(Hg2C5)[Er(C6NO2H4)3(H2O)2]}(HgCl2)·0.5CH3OH·0.5H2O (1) has been successfully synthesized via a hydrothermal reaction and structurally characterized by single-crystal X-ray diffraction.Complex 1 crystallizes in the space group C2/c of the monoclinic system with eight formula units in a cell:a =34.165(4)A,b=9.4692(8)A,c=24.575(3)A,,β=115.090(5)°,V=7200(1) A3,C18.50H21Cl7ErHg3N3Ol0Zn0.50,Mr=1495.25,Dc=2.759 g/cm3,T=293(2) K,μ(Mo Ka)=15.954 mm-1,F(000)=5400 and R1/wR2=O.0561/0.0909 for 3157 observed reflections [I>2σ(I)]and 6468 unique reflections.Complex 1 is characteristic of a novel 2D { (Hg2Cl5)[Er(C6NO2H4)3(H2O)2]} layered structure constructed from the [Er(C6NO2H4)3(H2O)2]chains interconnected by the Hg2Clˉ5 linkers.The 2D {(Hg2Cl5)[Er(C6NO2H4)3(H2O)2]} layers,mercury chloride and the lattice water molecules are held together via hydrogen bonds to form a three-dimensional framework with the methanol molecules and the hydrated zinc ions located in the cavities.The magnetic properties show that complex 1 exhibits antiferromagnetic-like interactions.

  11. Antimicrobial resistance profiles of Shiga toxin-producing Escherichia coli O157 and Non-O157 recovered from domestic farm animals in rural communities in Northwestern Mexico

    Directory of Open Access Journals (Sweden)

    Bianca A. Amézquita-López

    2016-01-01

    Full Text Available Abstract Background Antimicrobial resistance in Shiga toxin-producing Escherichia coli (STEC O157 and non-O157 is a matter of increasing concern. The aim of the present study was to investigate the antimicrobial resistance profiles of STEC O157 and non-O157 recovered from feces of domestic farm animals in the agricultural Culiacan Valley in Northwestern Mexico. Findings All of the examined STEC strains showed susceptibility to five antimicrobials, ceftazidime, ceftriaxone, ciprofloxacin, nalidixic acid, and trimethoprim-sulfamethoxazole. However, resistance to the four antimicrobials, ampicillin, cephalothin, chloramphenicol, and kanamycin was commonly observed. Interestingly, non-susceptibility to cephalothin was predominant among the examined STEC strains, corresponding to 85 % (22/26 of the O157:H7 from cattle, sheep and chicken and 73 % (24/33 of the non-O157 strains from cattle and sheep. Statistical analyses revealed that resistance to ampicillin was significantly correlated to 38 % (10/26 of STEC O157:H7 strains from multiple animal sources. Another significant correlation was found between serotype, source, and antimicrobial resistance; all of the O20:H4 strains, recovered from sheep, were highly resistant to tetracycline. Multidrug resistance profiles were identified in 42 % (22/53 of the non-susceptible STEC strains with clinically-relevant serotypes O8:H9, O75:H8, O146:H21, and O157:H7. Conclusions STEC O157 and non-O157 strains, recovered from domestic farm animals in the Culiacan Valley, exhibited resistance to classes of antimicrobials commonly used in Mexico, such as aminoglycosides, tetracyclines, cephalosporins and penicillin but were susceptible to fluoroquinolones, quinolones, and sulfonamides. These findings provide fundamental information that would aid in the surveillance of antimicrobial resistance in an important agricultural region in Northwestern Mexico.

  12. Characteristics of particulate carbon emissions from real-world Chinese coal combustion.

    Science.gov (United States)

    Zhang, Yuanxun; Schauer, James Jay; Zhang, Yuanhang; Zeng, Limin; Wei, Yongjie; Liu, Yuan; Shao, Min

    2008-07-15

    Particulate matter emissions from a series of different Chinese coal combustion systems were collected and analyzed for elemental and organic carbon (EC, OC), and molecular markers. Emissions from both industrial boilers and residential stoves were investigated. The coal used in this study included anthracite, bituminite, and brown coal, as well as commonly used coal briquettes produced in China for residential coal combustion. Results show significant differences in the contribution of carbonaceous species to particulate mass emissions. Industrial boilers had much higher burn out of carbon yielding particulate matter emissions with much lower levels of OC, EC, and speciated organic compounds, while residential stoves had significantly higher emissions of carbonaceous particulate matter with emission rates of approximately 100 times higher than that of industrial boilers. Quantified organic compounds emitted from industrial boilers were dominated by oxygenated compounds, of which 46-68% were organic acids, whereas the dominate species quantified in the emissions from residential stoves were PAHs (38%) and n-alkanes (20%). An important observation was the fact that emission factors of PAHs and the distribution of hopanoids were different among the emissions from industrial and residential coal combustion even using the same coal for combustion. Although particulate matter emissions from industrial and residential combustion were different in many regards, picene was detected in all samples with detectable OC mass concentrations, which supports the use of this organic tracer for OC from all types of coal combustion. 17alpha(H),21beta(H)-29-norhopane was the predominant hopanoid in coal combustion emissions, which is different from mobile source emissions and may be used to distinguish emissions from these different fossil fuel sources.

  13. Synthesis and Crystal Structure of [Copper(1,10-phenanthroline)2(pyridine)]perchlorates

    Institute of Scientific and Technical Information of China (English)

    牛德仲; 路再生; 马恒俊; 孙柏旺

    2001-01-01

    The complex [Cu(phen)2py](ClO4)2 was obtained by the reaction of 1,10-phenanthroline with Cu(C1O4)2·6H2O in water and by recrystallization from pyridine. A single-crystal X-ray study shows that the complex is a square pyramidal arrangement of five nitrogen atoms from the two 1,10-phenanthroline ligands and one pyridine ligand, respectively.The compound is orthorhombic, C29H21N5C12O8Cu, Mr = 701.958, with space group Pbcn,α = 29.9593(3), b = 16.1240(3), c = 11.9183(6)A, V= 5757.3(3)A3, Z = 8, Dc= 1.409g/cm3,μ =1.121 mm-1, F(000) = 2465, R = 0.0539, Rw = 0.1380 for 4293 reflections with I>2 σ(I). The bond lengths of Cu(1)-N(1), Cu(1)-N(2), Cu(1)-N(3) and Cu(1)-N(4) are 2.223(3),2.017(3), 2.013(3) and 2.038(3) A, respectively. The distance from copper to pyridine N(5) is 2.012(3) A. The angles N(2)-Cu(1)-N(3) and N(4)-Cu(1)-N(5) are 176.1(1)°and 160.9(1)°,respectively. The angles between axial position nitrogen atom N(1) and four square position nitrogen atoms N(2), N(3), N(4), N(5) are 79.3(1), 98.3(1), (1),108.4(1)°,respectively.

  14. Tramadol and Fentanyl and fentanyl Anesthesia Intravenous Postoperative Analgesia%曲马多复合芬太尼与芬太尼全麻术后静脉镇痛的比较

    Institute of Scientific and Technical Information of China (English)

    木也塞尔•艾买提; 热汗姑丽•台外库力

    2012-01-01

      目的探讨曲马多符合芬太尼治疗全麻术后静脉镇痛疗效。方法随机选择我院全麻手术,ASA 麻醉分级为1~2级患者87名,分成 A、B 两组,A 组31例,为对照组,行单独芬太尼注射;B 组56例,为治疗组,行曲马多复合芬太尼注射。结果 B 组3h、5h、11h、21h 呼吸频率高于 A 组,舒适评分高于 A 组,Ramsay 镇静评分高于 B 组,恶心、呕吐等不良反应发生率低于 B 组。结论曲马多复合芬太尼进行全麻术后静脉镇痛,具有较好的效果,不良反应发生率低。%  Objective Explore the tramadol in line with the intravenous analgesic effect of fentanyl treatment after general anesthesia. Methods Randomly selected hospital surgery under general anesthesia, the ASA anesthesia grade 1 to 2 patients of 87, divided into two groups (A, B),31 cases of group A, the control group, the line alone fentanyl injection; Group B 56 cases, in order totreatment group, the line tramadol fentanyl injection. Results Group B 3h,5h,11h,21h respiratory rate higher than Group A, the comfortable score higher than Group A, pain intensity was lower than group B, incidence of nausea, vomiting and other adverse reactions was lower than that in B group. Conclusion Tramadol fentanyl intravenous analgesia after general anesthesia, with good results and fewer adverse reactions.

  15. Colorimetric chemosensor of symmetrical benzoylthiourea derivatives as for detection of Cu2+ in aqueous solution

    Science.gov (United States)

    Hamedan, N. A.; Hasan, S.; Zaki, H. M.; Alias, N. Z.

    2017-02-01

    A novel receptor, designed with a combination of oxygen (O), nitrogen (N) and sulfur (S) -binding sites for metal ions was synthesized. Ortho (A), meta (B) and para (C) bearing benzoyl thiourea were designed and synthesized with triamine group to apply as colorimetric chemosensors for detection of Cu2+. The structure was confirmed by characterized the compound using Elemental analysis, Fourier Infrared (FTIR) and proton Nuclear Magnetic Resonance (1H NMR) spectroscopy. Functional groups of C=O, N-H, C=N and C=S were found at 1677 cm-1, 3240 cm-1, 1591 cm-1, 1024 cm-1 respectively while 1H NMR shows peaks of alkane (CH2), benzene (Ar-H), CONH, CSNH at 3.68 – 4.14, 7.16 – 7.86, 8.74, and 9.2 respectively. Elemental analysis for A, B and C C20H21N5O2S2Br2 found was compatible with the expected theoretical calculation. For an application, all of these three sensors showed excellent colorimetric specific selectivity and high sensitivity for Cu2+ in acetonitrile/water binary solutions, so only A was selected for further studies towards sensitivity. When Cu2+ was added to the solution of A, a dramatic color change from yellow to green, while other cations Fe2+, Zn2+, Ni2+, Co2+, Cr3+ and Mn2+ did not interfere with the recognition process for Cu2+. The detection limit of the sensor C toward Cu2+ was 1.15 x 10-5 M, which is less sensitive that sensor A and B with a detection limit of 6.2 x 10-6 M and 1.5 x 10-6 M respectively. This indicated that the sensor A and B might be useful as an efficient chemical sensor.

  16. Altered electroencephalographic activity associated with changes in the sleep-wakefulness cycle of C57BL/6J mice in response to a photoperiod shortening

    Directory of Open Access Journals (Sweden)

    Stanislav Rozov

    2016-08-01

    Full Text Available AimUnder natural conditions diurnal rhythms of biological processes of the organism are synchronized with each other and to the environmental changes by means of the circadian system. Disturbances of the latter affect hormonal levels, sleep-wakefulness cycle and cognitive performance. To study mechanisms of such perturbations animal models subjected to artificial photoperiods are often used. The goal of current study was to understand the effects of circadian rhythm disruption, caused by a short light-dark cycle regime, on activity of the cerebral cortex in rodents.MethodsWe used electroencephalogram to assess the distribution of vigilance states, perform spectral analysis, and estimate the homeostatic sleep drive. In addition, we analyzed spontaneous locomotion of C57BL/6J mice under symmetric, 22-h-, 21-h-, and 20-h-long light–dark cycles using video recording and tracking methods.Results and ConclusionsWe found that shortening of photoperiod caused a significant increase of slow wave activity during non-rapid eye movement sleep suggesting an elevation of sleep pressure under such conditions. While the rhythm of spontaneous locomotion was completely entrained by all light–dark cycles tested, periodic changes in the power of the θ- and γ-frequency ranges during wakefulness gradually disappeared under 22-h- and 21-h-long light–dark cycles. This was associated with a significant increase in the θ–γ phase-amplitude during wakefulness. Our results thus provide deeper understanding of the mechanisms underlying the impairment of learning and memory retention, which is associated with disturbed circadian regulation.

  17. Physiological and behavioural responses of Gammarus pulex (Crustacea: Amphipoda) exposed to cadmium

    Energy Technology Data Exchange (ETDEWEB)

    Felten, V. [Laboratoire d' Ecotoxicologie, CEMAGREF, 3 bis quai Chauveau, CP 220, 69336 Lyon Cedex 09 (France)], E-mail: vincent.felten@univ-reims.fr; Charmantier, G. [Equipe Adaptation Ecophysiologique et Ontogenese, UMR 5119 Ecolag, Universite Montpellier II, Place E. Bataillon, 34095 Montpellier Cedex 05 (France); Mons, R. [Laboratoire d' Ecotoxicologie, CEMAGREF, 3 bis quai Chauveau, CP 220, 69336 Lyon Cedex 09 (France); Geffard, A. [Laboratoire d' Eco-toxicologie, Universite de Reims Champagne Ardenne, Faculte des Sciences, Moulin de la Housse, BP 1039, 51687 Reims Cedex 2 (France); Rousselle, P. [Laboratoire Biodiversite et Fonctionnement des Ecosystemes, Universite de Metz, Campus Bridoux, Rue du General Delestraint, 57 070 Metz (France); Coquery, M. [Laboratoire de Chimie Environnementale, CEMAGREF, 3 bis quai Chauveau, CP 220, 69336 Lyon Cedex 09 (France); Garric, J.; Geffard, O. [Laboratoire d' Ecotoxicologie, CEMAGREF, 3 bis quai Chauveau, CP 220, 69336 Lyon Cedex 09 (France)

    2008-02-18

    The aim of this study was to investigate the effects of cadmium on physiological and behavioural responses in Gammarus pulex. In a first experiment, cadmium LC50s for different times were evaluated in 264 h experiment under continuous mode of exposure (LC50{sub 96h} = 82.1 {mu}g L{sup -1}, LC50{sub 120h} = 37.1 {mu}g L{sup -1}, LC50{sub 168h} = 21.6 {mu}g L{sup -1}, LC50{sub 264h} = 10.5 {mu}g L{sup -1}). In a second experiment, the physiological and behavioural responses of the amphipod exposed to cadmium (0, 7.5 and 15 {mu}g L{sup -1}) were investigated under laboratory conditions. The mortality and the whole body cadmium concentration of organisms exposed to cadmium were significantly higher than in controls. Concerning physiological responses, cadmium exposure exerted a significant decrease on osmolality and haemolymph Ca{sup 2+} concentration, but not on haemolymph Na{sup +} and Cl{sup -} concentrations, whereas the Na{sup +}/K{sup +}-ATPase activity was significantly increased. Behavioural responses, such as feeding rate, locomotor and ventilatory activities, were significantly reduced in Cd exposed organisms. Mechanism of cadmium action and consequent energetic reallocation in favour of maintenance functions (i.e., osmoregulation) are discussed. The results of this study indicate that osmolality and locomotor activity in G. pulex could be effective ecophysiological/behavioural markers to monitor freshwater ecosystem and to assess the health of organisms.

  18. In-stream attenuation of neuro-active pharmaceuticals and their metabolites

    Science.gov (United States)

    Writer, Jeffrey; Antweiler, Ronald C.; Ferrar, Imma; Ryan, Joseph N.; Thurman, Michael

    2013-01-01

    In-stream attenuation was determined for 14 neuro-active pharmaceuticals and associated metabolites. Lagrangian sampling, which follows a parcel of water as it moves downstream, was used to link hydrological and chemical transformation processes. Wastewater loading of neuro-active compounds varied considerably over a span of several hours, and thus a sampling regime was used to verify that the Lagrangian parcel was being sampled and a mechanism was developed to correct measured concentrations if it was not. In-stream attenuation over the 5.4-km evaluated reach could be modeled as pseudo-first-order decay for 11 of the 14 evaluated neuro-active pharmaceutical compounds, illustrating the capacity of streams to reduce conveyance of neuro-active compounds downstream. Fluoxetine and N-desmethyl citalopram were the most rapidly attenuated compounds (t1/2 = 3.6 ± 0.3 h, 4.0 ± 0.2 h, respectively). Lamotrigine, 10,11,-dihydro-10,11,-dihydroxy-carbamazepine, and carbamazepine were the most persistent (t1/2 = 12 ± 2.0 h, 12 ± 2.6 h, 21 ± 4.5 h, respectively). Parent compounds (e.g., buproprion, carbamazepine, lamotrigine) generally were more persistent relative to their metabolites. Several compounds (citalopram, venlafaxine, O-desmethyl-venlafaxine) were not attenuated. It was postulated that the primary mechanism of removal for these compounds was interaction with bed sediments and stream biofilms, based on measured concentrations in stream biofilms and a column experiment using stream sediments.

  19. Dinâmica espaço-temporal de flebotomíneos (Diptera, Psychodidae do município de Santa Quitéria, área de cerrado do Estado do Maranhão, Brasil Spatial-temporal dynamics of phlebotomine sandflies (Diptera, Psychodidae in the municipality of Santa Quitéria, "cerrado'' area, State of Maranhão, Brazil

    Directory of Open Access Journals (Sweden)

    Alexsandra M. C. B. Martin

    Full Text Available A flutuação sazonal, a freqüência horária e a ocorrência dos flebotomíneos nos ambientes intradomiciliar, peridomiciliar e extradomiciliar (cerrado, no município de Santa Quitéria, Estado do Maranhão foram estudados. Os espécimes foram capturados entre 18 e 6 horas, de maio de 1999 a abril de 2000, com armadilhas luminosas tipo CDC. Foram coletados 4.880 espécimes de 11 espécies. A riqueza e abundância foram maiores no peridomicílio (11 espécies; 50,1% dos espécimes, seguido pelo intradomicílio (9 espécies, 34% e cerrado (7 espécies, 15,8%. Duas espécies foram encontradas na estação chuvosa, uma na estiagem e oito em ambas estações. Na estiagem foram registradas elevadas freqüências de Lutzomyia longipalpis Lutz & Neiva, 1912 (88,4%, L. evandroi Costa Lima & Antunes, 1936 (83,6%, L. lenti Mangabeira, 1938 (86% e L. shannoni Dyar, 1929 (100%, enquanto as freqüências de L. quinquefer Dyar, 1929 (100% e L. whitmani Antunes & Coutinho, 1939 (75% foram maiores no período chuvoso. Os flebotomíneos foram encontrados a noite inteira, mas os horários de maior freqüência variaram de acordo com a espécie, observando-se picos no crepúsculo vespertino e primeiras horas da noite: L. quinquefer (18 h - 19 h; L. goiana Martins, Falcão & Silva, 1962 (18 h - 21 h; L. whitmani (19 h - 21 h e L. longipalpis (20 h - 21 h e ao longo da noite e no crepúsculo matutino: L. evandroi (21 h - 23 h e 3 h - 5 h, L. longipalpis (1 h - 3 h, L. lenti (22 h - 23 h e 4 h - 5 h. A ocorrência dos flebotomíneos nos diferentes ambientes, horários e estações vem sendo acompanhada por notificações de vários casos de leishmanioses cutânea e visceral.The seasonal fluctuation, hourly frequency and occurrence of phlebotomine sandflies inside and around dwellings and in the cerrado area of the municipality of Santa Quitéria, State of Maranhão were studied. The specimens were collected between 6:00 pm and 6:00 am from May 1999 to April 2000

  20. Crystal structures of two substituted thia-zolidine derivatives.

    Science.gov (United States)

    Viswanathan, Vijayan; Rao, Naga Siva; Raghunathan, Raghavachary; Velmurugan, Devadasan

    2016-08-01

    In the first of the compounds reported herein, namely 6'-ferrocenyl-6a'-nitro-6',6a',6b',7',9',11a'-hexa-hydro-2H-spiro-[ace-naphthyl-ene-1,11'-chromeno[3',4':3,4]pyrrolo-[1,2-c]thia-zol]-2-one, [Fe(C5H5)(C29H21N2O4S)], (I), the thia-zolidine ring adopts a twist conformation on the methine N-C atoms. In the second compound, viz. 6'-(4-methoxy-phen-yl)-6a'-nitro-6',6a',6b',7',9',11a'-hexa-hydro-2H-spiro-[ace-naphthyl-ene-1,11'-chromeno[3',4':3,4]pyrrolo-[1,2-c]thia-zol]-2-one, [Fe(C5H5)(C26H19N2O5S)], (II), the thia-zolidine ring adopts an envelope conformation with a methine C atom as the flap. In both compounds, the pyrrolidine ring adopts a twist conformation on the thia-zolidine and tetra-hydro-pyran C atoms. The mean planes of the thia-zolidine and pyrrolidine rings subtend angles of 67.30 (1) and 62.95 (7)° in (I) and (II), respectively, while the mean plane of the pyrrolidine ring makes dihedral angles of 76.53 (1) and 87.74 (7)° with the ace-naphthyl-ene ring system in (I) and (II), respectively. In both compounds, an intra-molecular C-H⋯O hydrogen bond forms an S(7) ring motif. In the crystal of (I), mol-ecules are linked via two different C-H⋯O hydrogen bonds, forming chains along [001] and [100]. In (II), they are linked through C-H⋯O hydrogen bonds, forming dimers with an R 2 (2)(10) ring motif while C-H⋯π inter-actions link the mol-ecules in a head-to-tail fashion, forming chains along the a-axis direction.

  1. Crystal structures of two substituted thia­zolidine derivatives

    Science.gov (United States)

    Viswanathan, Vijayan; Rao, Naga Siva; Raghunathan, Raghavachary; Velmurugan, Devadasan

    2016-01-01

    In the first of the compounds reported herein, namely 6′-ferrocenyl-6a′-nitro-6′,6a′,6b′,7′,9′,11a′-hexa­hydro-2H-spiro­[ace­naphthyl­ene-1,11′-chromeno[3′,4′:3,4]pyrrolo­[1,2-c]thia­zol]-2-one, [Fe(C5H5)(C29H21N2O4S)], (I), the thia­zolidine ring adopts a twist conformation on the methine N—C atoms. In the second compound, viz. 6′-(4-methoxy­phen­yl)-6a′-nitro-6′,6a′,6b′,7′,9′,11a′-hexa­hydro-2H-spiro­[ace­naphthyl­ene-1,11′-chromeno[3′,4′:3,4]pyrrolo­[1,2-c]thia­zol]-2-one, [Fe(C5H5)(C26H19N2O5S)], (II), the thia­zolidine ring adopts an envelope conformation with a methine C atom as the flap. In both compounds, the pyrrolidine ring adopts a twist conformation on the thia­zolidine and tetra­hydro­pyran C atoms. The mean planes of the thia­zolidine and pyrrolidine rings subtend angles of 67.30 (1) and 62.95 (7)° in (I) and (II), respectively, while the mean plane of the pyrrolidine ring makes dihedral angles of 76.53 (1) and 87.74 (7)° with the ace­naphthyl­ene ring system in (I) and (II), respectively. In both compounds, an intra­molecular C—H⋯O hydrogen bond forms an S(7) ring motif. In the crystal of (I), mol­ecules are linked via two different C—H⋯O hydrogen bonds, forming chains along [001] and [100]. In (II), they are linked through C—H⋯O hydrogen bonds, forming dimers with an R 2 2(10) ring motif while C—H⋯π inter­actions link the mol­ecules in a head-to-tail fashion, forming chains along the a-axis direction. PMID:27536396

  2. Metabolism and antioxidant defense in the larval chironomid Tanytarsus minutipalpus: adjustments to diel variations in the extreme conditions of Lake Magadi

    Science.gov (United States)

    Wood, Chris M.; Bergman, Harold L.; Johannsson, Ora E.; Laurent, Pierre; Chevalier, Claudine; Kisipan, Mosiany L.; Kavembe, Geraldine D.; Papah, Michael B.; Brix, Kevin V.; De Boeck, Gudrun; Maina, John N.; Ojoo, Rodi O.; Bianchini, Adalto

    2017-01-01

    ABSTRACT Insect larvae are reported to be a major component of the simple but highly productive trophic web found in Lake Magadi (Kenya, Africa), which is considered to be one of the most extreme aquatic environments on Earth. Previous studies show that fish must display biochemical and physiological adjustments to thrive under the extreme conditions of the lake. However, information for invertebrates is lacking. In the present study, the occurrence of the larval chironomid Tanytarsus minutipalpus is reported in Lake Magadi for the first time. Additionally, changes in larval metabolism and antioxidant defense correlated with diel variations in the extremely hostile environmental conditions of the lake are described. Wide variations in water temperature (20.2-29.3°C) and dissolved oxygen content (3.2-18.6 mg O2 l−1) were observed at different times of day, without significant change in water pH (10.0±0.03). Temperature and dissolved oxygen were higher at 13:00 h (29.3±0.4°C and 18.6±1.0 mg O2 l−1) and 19:00 h (29.3±0.8°C and 16.2±1.6 mg O2 l−1) and lower at 01:00 h (21.1±0.1°C and 10.7±0.03 mg O2 l−1) and 07:00 h (20.2±0.4°C and 3.2±0.7 mg O2 l−1). Significant and parallel increases in parameters related to metabolism (cholinesterase, glucose, cholesterol, urea, creatinine and hemoglobin) and the antioxidant system (SOD, GPx, GR, GSH and GSSG) were observed in larvae collected at 13:00 h. In contrast, no significant changes were observed in pro-oxidants (ROS and NO), TOSC and oxidative damage parameters (LPO and DNA damage). Therefore, the observed increases in temperature and dissolved O2 content in Lake Magadi were associated with changes in the antioxidant system of T. minutipalpus larvae. Adjustments performed by the chironomid larvae were efficient in maintaining body homeostasis, as well as protecting biomolecules against oxidative damage, so that oxidative stress did not occur. GSH-GSSG and GPx-GR systems appeared to

  3. Metabolism and antioxidant defense in the larval chironomid Tanytarsus minutipalpus: adjustments to diel variations in the extreme conditions of Lake Magadi

    Directory of Open Access Journals (Sweden)

    Lucas F. Bianchini

    2017-01-01

    Full Text Available Insect larvae are reported to be a major component of the simple but highly productive trophic web found in Lake Magadi (Kenya, Africa, which is considered to be one of the most extreme aquatic environments on Earth. Previous studies show that fish must display biochemical and physiological adjustments to thrive under the extreme conditions of the lake. However, information for invertebrates is lacking. In the present study, the occurrence of the larval chironomid Tanytarsus minutipalpus is reported in Lake Magadi for the first time. Additionally, changes in larval metabolism and antioxidant defense correlated with diel variations in the extremely hostile environmental conditions of the lake are described. Wide variations in water temperature (20.2-29.3°C and dissolved oxygen content (3.2-18.6 mg O2 l−1 were observed at different times of day, without significant change in water pH (10.0±0.03. Temperature and dissolved oxygen were higher at 13:00 h (29.3±0.4°C and 18.6±1.0 mg O2 l−1 and 19:00 h (29.3±0.8°C and 16.2±1.6 mg O2 l−1 and lower at 01:00 h (21.1±0.1°C and 10.7±0.03 mg O2 l−1 and 07:00 h (20.2±0.4°C and 3.2±0.7 mg O2 l−1. Significant and parallel increases in parameters related to metabolism (cholinesterase, glucose, cholesterol, urea, creatinine and hemoglobin and the antioxidant system (SOD, GPx, GR, GSH and GSSG were observed in larvae collected at 13:00 h. In contrast, no significant changes were observed in pro-oxidants (ROS and NO, TOSC and oxidative damage parameters (LPO and DNA damage. Therefore, the observed increases in temperature and dissolved O2 content in Lake Magadi were associated with changes in the antioxidant system of T. minutipalpus larvae. Adjustments performed by the chironomid larvae were efficient in maintaining body homeostasis, as well as protecting biomolecules against oxidative damage, so that oxidative stress did not occur. GSH-GSSG and GPx-GR systems appeared to

  4. The Study of Children Patients With Mycoplasma Pneumonia Infection With Clinical Testing Analysis%临床检验分析对小儿肺炎支原体感染的研究

    Institute of Scientific and Technical Information of China (English)

    赵文凤; 周文斌

    2015-01-01

    Objective Clinical testing methods for children patients with mycoplasma pneumonia infection are to be studied.MethodsReviewed and analyzed clinical testing results selected from 41 children patients with mycoplasma pneumonia infection who were treated in hospital from April 2013 to April 2015.Results There were 33 normal cases and 8 abnormal cases tested by urine routine examination respectively,11 cases of leucocytes count 10.0×109/L,7 cases of platelets count 20 mm/h,21 cases’ CRP >10 mg/L;11 cases of bacteria culture results were positive.Conclusion For treatment children patients with mycoplasma pneumonia infection,it is suggested to apply a comprehensive analysis to clinical testing,including urine routine test,blood routine test,vigor analysis,passive agglutination test and bacterial culture of sputum,etc,in order to improve diagnosis accuracy and prevent from misdiagnosis.%目的:深入研究小儿肺炎支原体感染的临床检验方法。方法选取于2013年4月~2015年4月期间在我院接受治疗的41例小儿肺炎支原体感染患儿的临床检验结果进行回顾性分析。结果尿常规检查正常的有33例,异常8例;11例白细胞计数<4.0×109/L,8例白细胞计数在(4.0~10.0)×109/L,22例白细胞计数>10.0×109/L;7例血小板<100×109/L,34例血小板≥100×109/L;表现为MP-IgM阳性的有27例;20例血沉>20 mm/h,21例CRP>10 mg/L;11例细菌培养结果显示为阳性。结论在对小儿肺炎支原体感染进行诊断时,要通过尿常规、血常规、血气分析、被动凝集试验、对痰液进行细菌培养等临床检验进行综合分析,提高确诊率,避免出现漏诊误诊的情况。

  5. Occurrence and characterization of Shiga toxin-producing Escherichia coli O157:H7 and other non-sorbitol-fermenting E. coli in cattle and humans in urban areas of Morogoro, Tanzania.

    Science.gov (United States)

    Lupindu, Athumani M; Olsen, John E; Ngowi, Helena A; Msoffe, Peter L M; Mtambo, Madundo M; Scheutz, Flemming; Dalsgaard, Anders

    2014-07-01

    Escherichia coli strains such as Shiga toxin-producing E. coli (STEC), enteropathogenic E. coli, enterotoxigenic, attaching, and effacing E. coli, and enteroinvasive E. coli cause diarrhea in humans. Although other serotypes exist, the most commonly reported STEC in outbreaks is O157:H7. A cross-sectional study was conducted to isolate and characterize non-sorbitol-fermenting (NSF) E. coli O157:H7 from urban and periurban livestock settings of Morogoro, Tanzania. Human stool, cattle feces, and soil and water samples were collected. Observations and questionnaire interview studies were used to gather information about cattle and manure management practices in the study area. E. coli were isolated on sorbitol MacConkey agar and characterized by conventional biochemical tests. Out of 1049 samples, 143 (13.7%) yielded NSF E. coli. Serological and antimicrobial tests and molecular typing were performed to NSF E. coli isolates. These procedures detected 10 (7%) pathogenic E. coli including STEC (n=7), enteropathogenic E. coli (EPEC) (n=2), and attaching and effacing E. coli (A/EEC) (n=1) strains. The STEC strains had the ability to produce VT1 and different VT2 toxin subtypes that caused cytopathic effects on Vero cells. The prevalence of STEC in cattle was 1.6%, out of which 0.9% was serotype O157:H7 and the overall prevalence of diarrheagenic E. coli in cattle was 2.2%. The serotypes O157:H7, O142:H34, O113:H21, O+:H-, O+:H16, and O25:H4 were identified. One ESBL-producing isolate showed the MLST type ST131. To our knowledge, this is the first finding in Tanzania of this recently emerged worldwide pandemic clonal group, causing widespread antimicrobial-resistant infections, and adds knowledge of the geographical distribution of ST131. Cattle manure was indiscriminately deposited within residential areas, and there was direct contact between humans and cattle feces during manure handling. Cattle and manure management practices expose humans, animals, and the environment

  6. Extensive analysis of N-H...O hydrogen bonding in four classes of phosphorus compounds: a combined experimental and database study.

    Science.gov (United States)

    Hamzehee, Farahnaz; Pourayoubi, Mehrdad; Nečas, Marek; Choquesillo-Lazarte, Duane

    2017-03-01

    The N-H...O hydrogen bond is the characteristic interaction in the crystal structures of N-benzyl-P-phenyl-N'-(p-tolyl)phosphonic diamide, C20H21N2OP or (C6H5)P(O)(NHCH2C6H5)(NHC6H4-p-CH3), (I), diphenylphosphinic 1-methylpropylamide, C16H20NOP or (C6H5)2P(O)[NHCH(CH3)(C2H5)], (II), (S)-1-phenylethylammonium N-[(S)-1-phenylethyl]phenylphosphonamidate, C8H12N(+)·C14H15NO2P(-) or [S-(C6H5)CH(CH3)NH3][(C6H5)P(O){S-NHCH(CH3)(C6H5)}(O)], (III), and (4-methylbenzyl)ammonium diphenylphosphinate, C8H12N(+)·C12H10O2P(-) or [4-CH3-C6H4CH2NH3][(C6H5)2P(O)(O)], (IV). This article focuses on the N-H...O hydrogen bonds by considering the structures of (I), (II), (III) and (IV), and reviewing their analogous compounds, including 43 (C)P(O)(N)2, 102 (C)2P(O)(N), 31 (C)P(O)(N)(O) and 96 (C)2P(O)(O) structures, deposited in the Cambridge Structural Database (CSD). For the structures with a (C)P(O)(N)2 segment, only neutral hydrogen bonds were found in the CSD. The other three classes of compounds included both neutral and `charge-assisted' hydrogen bonds, and the (C)2P(O)(O) structures were particularly noticeable for a high number of cation-anion compounds. The overall tendencies of N...O distances in neutral and cation-anion compounds were compared. The N-H...O hydrogen-bond angles were also analyzed for the four classes of phosphorus compounds.

  7. Effective interactions between nanoparticles: Creating temperature-independent solvation environments for self-assembly

    Science.gov (United States)

    Yadav, Hari O. S.; Shrivastav, Gourav; Agarwal, Manish; Chakravarty, Charusita

    2016-06-01

    The extent to which solvent-mediated effective interactions between nanoparticles can be predicted based on structure and associated thermodynamic estimators for bulk solvents and for solvation of single and pairs of nanoparticles is studied here. As a test of the approach, we analyse the strategy for creating temperature-independent solvent environments using a series of homologous chain fluids as solvents, as suggested by an experimental paper [M. I. Bodnarchuk et al., J. Am. Chem. Soc. 132, 11967 (2010)]. Our conclusions are based on molecular dynamics simulations of Au140(SC10H21)62 nanoparticles in n-alkane solvents, specifically hexane, octane, decane and dodecane, using the TraPPE-UA potential to model the alkanes and alkylthiols. The 140-atom gold core of the nanocrystal is held rigid in a truncated octahedral geometry and the gold-thiolate interaction is modeled using a Morse potential. The experimental observation was that the structural and rheological properties of n-alkane solvents are constant over a temperature range determined by equivalent solvent vapour pressures. We show that this is a consequence of the fact that long chain alkane liquids behave to a good approximation as simple liquids formed by packing of monomeric methyl/methylene units. Over the corresponding temperature range (233-361 K), the solvation environment is approximately constant at the single and pair nanoparticle levels under good solvent conditions. However, quantitative variations of the order of 10%-20% do exist in various quantities, such as molar volume of solute at infinite dilution, entropy of solvation, and onset distance for soft repulsions. In the opposite limit of a poor solvent, represented by vacuum in this study, the effective interactions between nanoparticles are no longer temperature-independent with attractive interactions increasing by up to 50% on decreasing the temperature from 361 K to 290 K, accompanied by an increase in emergent anisotropy due to

  8. In Vitro Bactericidal Effects of 625, 525, and 425 nm Wavelength (Red, Green, and Blue) Light-Emitting Diode Irradiation

    Science.gov (United States)

    Kim, SangWoo; Kim, JiSun; Lim, WonBong; Jeon, SangMi; Kim, OkSu; Koh, Jeong-Tae; Kim, Chang-Su; Choi, HongRan

    2013-01-01

    Abstract Objective: The purpose of this study was to evaluate the relationship of 625, 525, and 425 nm wavelengths, providing average power output and effects on three common pathogenic bacteria. Background data: Ultraviolet (UV) light kills bacteria, but the bactericidal effects of UV may not be unique, as 425 nm produces a similar effect. The bactericidal effects of light-emitting diode (LED) wavelengths such as 625 and 525 nm have not been described. Before conducting clinical trials, the appropriate wavelength with reasonable dose and exposure time should be established. Materials and methods: The bactericidal effects of 625, 525, and 425 nm wavelength LED irradiation were investigated in vitro for the anaerobic bacterium Porphyromonas gingivalis and two aerobes (Staphylococcus aureus and Escherichia coli DH5α). Average power output was 6 mW/cm2 for 1 h. The bacteria were exposed to LED irradiation for 1, 2, 4, and 8 h (21.6, 43.2, 86.4, and 172.8 J/cm2, respectively). LED irradiation was performed during growth on agar and in broth. Control bacteria were incubated without LED irradiation. Bacterial growth was expressed in colony-forming units (CFU) and at an optical density at 600 nm in agar and broth. Results: The bactericidal effect of LED phototherapy depended upon wavelength, power density, bacterial viable number, and bacteria species. The bactericidal effect of 425 and 525 nm irradiation varied depending upon the bacterial inoculation, compared with unirradiated samples and samples irradiated with red light. Especially, P. gingivalis and E. coli DH5α were killed by 425 nm, and S. aureus growth was inhibited by 525 nm. However, the wavelength of 625 nm was not bactericidal for P. gingivalis, E. coli DH5α, or S. aureus. Conclusions: Irradiation at 625 nm light was not bactericidal to S. aureus, E. coli, and P. gingivalis, whereas wavelengths of 425 and 525 nm had bactericidal effects. S. aureus was also killed at 525

  9. Structures and Spectroscopy Studies of Two M(II-Phosphonate Coordination Polymers Based on Alkaline Earth Metals (M = Ba, Mg

    Directory of Open Access Journals (Sweden)

    Kui-Rong Ma

    2013-01-01

    Full Text Available The two examples of alkaline-earth M(II-phosphonate coordination polymers, [Ba2(L(H2O9]·3H2O (1 and [Mg1.5(H2O9]·(L-H21.5·6H2O (2 (H4L = H2O3PCH2N(C4H8NCH2PO3H2, N,N′-piperazinebis(methylenephosphonic acid, (L-H2 = O3PH2CHN(C4H8NHCH2PO3 have been hydrothermally synthesized and characterized by elemental analysis, FT-IR, PXRD, TG-DSC, and single-crystal X-ray diffraction. Compound 1 possesses a 2D inorganic-organic alternate arrangement layer structure built from 1D inorganic chains through the piperazine bridge, in which the ligand L−4 shows two types of coordination modes reported rarely at the same time. In 1, both crystallographic distinct Ba(1 and Ba(2 ions adopt 8-coordination two caps and 9-coordination three caps triangular prism geometry structures, respectively. Compound 2 possesses a zero-dimensional mononuclear structure with two crystallographic distinct Mg(II ions. Free metal cations   [MgO6]n2+ and uncoordinated anions (L-H2n2- are joined together by static electric force. Results of photoluminescent measurement indicate three main emission bands centered at 300 nm, 378.5 nm, and 433 nm for 1 and 302 nm, 378 nm, and 434.5 nm for 2 (λex=235 nm, respectively. The high energy emissions could be derived from the intraligand π∗-n transition stations of H4L (310 nm and 382 nm, λex=235 nm, while the low energy emission (>400 nm of 1-2 may be due to the coordination effect with metal(II ions.

  10. Steranes and triterpanes in the Beacon Supergroup samples from southern Victoria Land in Antarctica

    Science.gov (United States)

    Matsumoto, Genki I.; Machihara, Tsutomu; Suzuki, Noriyuki; Funaki, Minoru; Watanuki, Kunihiko

    1987-10-01

    Steranes and triterpanes in Beacon Supergroup samples (sedimentary rock and silicified wood) from Allan Hills and Carapace Nunatak of southern Victoria Land in Antarctica were studied to elucidate sources of organic materials, sedimentary paleoenvironment and thermal history after deposition. Relative abundances of C 27, C 28 and C 29 steranes and visual kerogen results of Beacon Supergroup samples from Allan Hills imply that organic materials in the sedimentary paleoenvironments are contributed mainly by vascular plants with some influence of microorganisms, while those of the Carapace Nunatak sample may be largely due to fern spores. The pristane/phytane and pristane/heptadecane ratios of the samples were generally close to unity and between 0.50 and 0.99, respectively, suggesting that the sedimentary paleoenvironment was shallow lacustrine with alternating oxic and anoxic conditions. The ( 22S/22R)-17α(H),21β(H)-C 31-C 33 triterpane ratios are approximately at thermal equilibrium values ( ca. 1.5) in most samples, while the ( 20S/20R)-5α(H), 14α(H), 17α(H)-C 29 sterane ratios and the (20R + 20S)-5α(H), 14β(H), 17β(H)/5α(H), 14α(H), 17α(H)-C 29 sterane ratios vary from 0.0 to 1.1 and from 0.0 to 1.4, respectively. Most of the ( 20S/20R)-5α(H), 14α(H), 17α(H)-C 29 sterane ratios did not reach thermal equilibrium values. The correlation coefficient between the ( 20S/20R)-5α(H), 14α(H), 17α(H)-C 29 sterane ratios and (20R + 20S)-5α(H), 14β(H), 17β(H)/5α(H), 14α(H), 17α(H)-C 29, sterane ratios is very high (0.96). These variable maturities probably reflect thermal effects of basaltic dikes on the Beacon Supergroup at Allan Hills and Carapace Nunatak during Jurassic time. Thermal stresses on the Beacon Supergroup prior to basaltic intrusion have been estimated to be quite low, so the paleotemperatures of this formation have been quite low.

  11. From farm to table: follow-up of Shiga toxin-producing Escherichia coli throughout the pork production chain in Argentina

    Directory of Open Access Journals (Sweden)

    Rocío eColello

    2016-02-01

    Full Text Available Pigs are important reservoirs of Shiga toxin-producing Escherichia coli (STEC. The entrance of these strains into the food chain implies a risk to consumers because of the severity of hemolytic uremic syndrome. This study reports the prevalence and characterization of Shiga toxin-producing Escherichia coli (STEC throughout the pork production chain. From 764 samples, 31 (4.05% were stx positive by PCR screening. At farms, 2.86% of samples were stx positive; at slaughter, 4.08% of carcasses were stx positive and at boning rooms, 6% of samples were stx positive. These percentages decreased in pork meat ready for sale at sales markets (4.59%. From positive samples, 50 isolates could be characterized. At farms 37.5% of the isolates carried stx1/stx2 genes, 37.5% possessed stx2e and 25%, carried only stx2. At slaughter we detected 50% of isolates positive for stx2, 33% for stx2e and 16% for stx1/stx2. At boning rooms 59% of the isolates carried stx1/stx2, 14% stx2e and 5% stx1/stx2/stx2e. At retail markets 66% of isolates were positive for stx2, 17% stx2e and 17% stx1/stx2. For the other virulence factors, ehxA and saa were not detected and eae gene was detected in 12% of the isolates. Concerning putative adhesins, agn43 was detected in 72%, ehaA in 26%, aida in 8% and iha in 6% of isolates. The strains were typed into 14 E. coli O groups (O1, O2, O8, O15, O20, O35, O69, O78, O91, O121, O138, O142, O157, O180 and ten H groups (H9, H10, H16, H21, H26, H29, H30, H32, H45, H46. This study reports the prevalence and characterization of STEC strains through the chain pork suggesting the vertical transmission. STEC contamination originates in the farms and is transferred from pigs to carcasses in the slaughter process and increase in meat pork at boning rooms and sales markets. These results highlight the need to implement an integrated STEC control system based on good management practices on the farm and critical control point systems in the food chain.

  12. 紫杉醇脂质体联合顺铂、氟尿嘧啶一线治疗晚期胃癌的临床观察%A phase Ⅱ trial of paclitaxel liposome plus cisplatin and 5-fluorouracil as first line chemotherapy for advanced gastric cancer

    Institute of Scientific and Technical Information of China (English)

    鄢俊; 邱峰; 钟志宏; 张凌; 项晓军; 余锋; 熊建萍

    2009-01-01

    目的:评价紫杉醇脂质体联合顺铂、氟尿嘧啶(PCF方案)一线治疗晚期胃癌的临床疗效和毒副反应.方法:PCF方案一线治疗42例晚期胃癌的具体用法:紫杉醇脂质体175mg/m2 ,第1天静滴90min;顺铂75mg/m2,第1天静滴;亚叶酸钙400mg/m2,第1天滴注2h;氟尿嘧啶2.6g/m2,亚叶酸钙滴注结束后立即持续泵入46h.21天为1周期,每2周期按RESIST标准评价疗效,所有患者至少接受2周期化疗.结果:42例患者共接受192个周期的化疗,所有患者均可评价疗效.完全缓解3例(7.1%),部分缓解20例(47.6%),稳定12例(28.6%),进展7例,总有效率为54.8%,中位进展时间(TTP)6.5个月,中位生存时间(MST)13.9个月.常见的不良反应为血液学毒性,胃肠反应、肌肉酸痛、外周神经毒性较轻,以Ⅰ、Ⅱ级为主.10例(23.8%)发生Ⅲ~Ⅳ级粒细胞减少,伴发热1例(2.4%);Ⅲ级恶心呕吐反应4例(9.5%),Ⅲ级肌肉酸痛3例(7.1%),Ⅲ级外周神经毒性2例(4.7%),无化疗相关性死亡病例.结论:紫杉醇脂质体联合顺铂、氟尿嘧啶(PCF方案)一线治疗晚期胃癌疗效确切,不良反应轻,值得临床推广应用.

  13. Electrochemical Properties of Organosilane Self Assembled Monolayers on Aluminum 2024

    Science.gov (United States)

    Hintze, Paul E.; Calle, Luz Marina

    2004-01-01

    Self assembled monolayers are commonly used to modify surfaces. Within the last 15 years, self assembled monolayers have been investigated as a way to protect from corrosion[1,2] or biofouling.[3] In this study, self assembled monolayers of decitriethoxysilane (C10H21Si(OC2H5)3) and octadecyltriethoxysilane (C18H37Si(OC2H5)3) were formed on aluminum 2024-T3. The modified surfaces and bare Al 2024 were characterized by dynamic water contact angle measurements, x-ray photoelectron spectroscopy (XIPS) and infrared spectroscopy. Electrochemical impedance spectroscopy (EIS) in 0.5 M NaCl was used to characterize the monolayers and evaluate their corrosion protection properties. The advancing water contact angle and infrared measurements show that the mono layers form a surface where the hydrocarbon chains are packed and oriented away from the surface, consistent with what is found in similar systems. The contact angle hysteresis measured in these systems is relatively large, perhaps indicating that the hydrocarbon chains are not as well packed as monolayers formed on other substrates. The results of the EIS measurements were modeled using a Randle's circuit modified by changing the capacitor to a constant phase element. The constant phase element values were found to characterize the monolayer. The capacitance of the monolayer modified surface starts lower than the bare Al 2024, but approaches values similar to the bare Al 2024 within 24 hours as the monolayer is degraded. The n values found for bare Al 2024 quickly approach the value of a true capacitor and are greater than 0.9 within hours after the start of exposure. For the monolayer modified structure, n can stay lower than 0.9 for a longer period of time. In fact, n for the monolayer modified surfaces is different from the bare surface even after the capacitance values have converged. This indicates that the deviation from ideal capacitance is the most sensitive indicator of the presence of the monolayer.

  14. Genotypic analyses of shiga toxin-producing Escherichia coli O157 and non-O157 recovered from feces of domestic animals on rural farms in Mexico.

    Science.gov (United States)

    Amézquita-López, Bianca A; Quiñones, Beatriz; Cooley, Michael B; León-Félix, Josefina; Castro-del Campo, Nohelia; Mandrell, Robert E; Jiménez, Maribel; Chaidez, Cristóbal

    2012-01-01

    Shiga toxin-producing Escherichia coli (STEC) are zoonotic enteric pathogens associated with human gastroenteritis worldwide. Cattle and small ruminants are important animal reservoirs of STEC. The present study investigated animal reservoirs for STEC in small rural farms in the Culiacan Valley, an important agricultural region located in Northwest Mexico. A total of 240 fecal samples from domestic animals were collected from five sampling sites in the Culiacan Valley and were subjected to an enrichment protocol followed by either direct plating or immunomagnetic separation before plating on selective media. Serotype O157:H7 isolates with the virulence genes stx2, eae, and ehxA were identified in 40% (26/65) of the recovered isolates from cattle, sheep and chicken feces. Pulse-field gel electrophoresis (PFGE) analysis grouped most O157:H7 isolates into two clusters with 98.6% homology. The use of multiple-locus variable-number tandem repeat analysis (MLVA) differentiated isolates that were indistinguishable by PFGE. Analysis of the allelic diversity of MLVA loci suggested that the O157:H7 isolates from this region were highly related. In contrast to O157:H7 isolates, a greater genotypic diversity was observed in the non-O157 isolates, resulting in 23 PFGE types and 14 MLVA types. The relevant non-O157 serotypes O8:H19, O75:H8, O111:H8 and O146:H21 represented 35.4% (23/65) of the recovered isolates. In particular, 18.5% (12/65) of all the isolates were serotype O75:H8, which was the most variable serotype by both PFGE and MLVA. The non-O157 isolates were predominantly recovered from sheep and were identified to harbor either one or two stx genes. Most non-O157 isolates were ehxA-positive (86.5%, 32/37) but only 10.8% (4/37) harbored eae. These findings indicate that zoonotic STEC with genotypes associated with human illness are present in animals on small farms within rural communities in the Culiacan Valley and emphasize the need for the development of control

  15. Synthesis and Crystal Structure of {N,N-bis[(1-methy-limidazol-2-yl)methyl]-β-alanine methylester]}dichlorocobalt(Ⅱ)%N,N-二(1-甲基咪唑基-1-亚甲叉)-β-丙氨酸甲酯二氯化钴(Ⅱ)配合物的合成与晶体结构

    Institute of Scientific and Technical Information of China (English)

    孙景佳; 陈佳民; 劳雁妮; 杨仕平

    2007-01-01

    一个新颖的N,N-二(1-甲基咪唑基-1-亚甲叉)-β-丙氨酸甲酯二氯化钴(Ⅱ)配合物被合成得到,并通过元素分析与X-射线单晶衍射手段对其结构进行了表征.晶体属于三斜晶系,P-1空间群,其中a=7.4540(9),b=10.2345(13),c=13.5999(17)(A),α=102.884(2),β=102.657(2),γ=107.548(2)v,V=917.4(2)(A)3,Mr=421.19,Z=2,Dc=1.525 g/cm3.单晶结构分析表明,钴(Ⅱ)被两个氯原子、两个咪唑环的氮原子与叔胺的氮原子所配位,构成一新颖的五配位的三角双锥配位环境,通过碳上的氢原子与氯原子和酯基的氧之间形成的非典型氢键使得分子构成三维的空间结构.%A new complex CoLCl2(L=N,N-bis[(1-methylimidazol-2-yl)methyl]alanine methylester)was synthesized and its crystal structure was determined by single-crystal x-ray diffraction.Crystal data:C14H21Cl2CoN5O2,triclinic,space group P-1 with a=7.4540(9),b=10.2345(13),c=13.5999(17)(A),α=102.884(2),β =102.657(2),γ=107.548(2)v,V=917.4(2)(A)3,Mr=421.19,Z=2,Dc=1.525 g/cm3,F(000)=434,μ=1.243 mm-1,the final R=0.0500 and wR=0.0712 for 2519 observed reflections(I 2(Ⅰ)).The Co (Ⅱ)atom wsa coordinated in trigonal bipyramid geometry by two chloride atoms,two imidazole nitogen atoms and a tertiary amine N atom.Structure analysis indicated that the structure was consolidated by some non-classical intermolecular and intramolecular weak hydrogen bonds which formed a three dimensional network in the solid.

  16. Comparative chlorine and temperature tolerance of the oyster Crassostrea madrasensis: implications for cooling system fouling.

    Science.gov (United States)

    Rajagopal, S; Venugopalan, V P; van der Velde, G; Jenner, H A

    2003-04-01

    Crassostrea madrasensis is an important fouling oyster in tropical industrial cooling water systems. C. madrasensis individuals attach to surfaces by cementing one of their two valves to the substratum. Therefore, oyster fouling creates more problems than mussel fouling in the cooling conduits of power stations, because unlike the latter, the shell of the former remains attached to the substratum even after the death of the animal. However, there are no published reports on the tolerance of this species to chlorination and heat treatment. The mortality pattern and physiological behaviour (oxygen consumption and filtration rate) of three size groups (13 mm, 44 mm and 64 mm mean shell length) of C. madrasensis were studied at different residual chlorine concentrations (0.25, 0.5, 0.75, 1, 2, 3 to 5 mg 1-1) and temperatures (30 degrees C to 45 degrees C). The effect of shell size (= age) on C. madrasensis mortality in the presence of chlorine and taking into account temperature was significant, with the largest size group oysters showing highest resistance. At 1 mg l-1 residual chlorine, the 13 mm and 64 mm size group oysters, took 504 h (21 d) and 744 h (31 d), respectively to reach 100% mortality. At 39 degrees C, the 13 mm size group oysters took 218 min to reach 100% mortality, whereas the 64 mm size group oysters took 325 min. The oxygen consumption and filtration rate of C. madrasensis showed progressive reduction with increasing residual chlorine concentrations. However, the filtration rate and oxygen consumption responses of C. madrasensis were not significantly different between 30 degrees C (control) and 37.5 degrees C. There was a sharp decrease in the filtration rate and oxygen consumption at 38.5 degrees C. A comparison of the present mortality data with previous reports on other bivalves suggests that the chlorine tolerance of C. madrasensis lies in between that of Perna viridis and Perna perna, while its temperature tolerance is significantly higher

  17. Thermodynamics Analysis of Cesium Adsorption on Na2Ti2O3SiO4 · 2H2O%钛硅酸钠( Na2Ti2O3SiO4·2H2O)对Cs的吸附热力学分析

    Institute of Scientific and Technical Information of China (English)

    王保柱; 张东; 石正坤; 吴涛

    2012-01-01

    钛硅酸钠(Crystalline Sillicotitanate,CST)对铯(Cs)的吸附热力学分析是研究钛硅酸钠吸附铯机理的重要途径之一.本工作通过研究不同温度下CST与不同浓度CsNO3溶液反应,测定反应前后Cs+的浓度变化,得到了一系列参数.结果显示,不同的反应温度对应不同的饱和吸附量,当温度为298.15、313.15和328.15 K时,饱和吸附量分别为212.8、217.4和232.6 mg/g.分别用Langmuir方程和Freundlich方程对实验数据进行拟合,结果表明,此吸附过程更符合Langmuir等温吸附.在不考虑温度对吸附焓和吸附熵影响的前提下,计算得到吸附焓△H=21.28 kJ/mol,△S=89.18 J/K/mol以及△G<0.以上结果表明,CST对Cs的吸附过程是一个自发进行、既有物理吸附又有化学吸附的吸热反应.%Thermodynamical analysis of cesium adsorption on CST is considered to be one of the important approaches in studying the adsorption mechanism of cesium on CST. A series of parameters were obtained by measuring the change of the Cs+ ion concentration before and after the sorption. The CST sorption experiments were conducted with the CsNO3 solution at different concentrations and temperatures. The saturation adsorption was found to be 212.8, 217.4 and 232.6 mg/g at 298. 15, 313. 15 and 328. 15 K, respectively. The experimental data were fitted with the Langmuir model or the Freundlich model. The results showed that the Langmuir isotherm better fits this adsorption process. With the assumption that the adsorption enthalpy and adsorption entropy are independent of the temperature, theadsorption enthalpy and entropy were calculated to be 21. 28 kJ/mol and 89. 18 J ? K-1 ? Mol-1 , respectively, with a negative adsorption free energy. The results indicated that the adsorption of cesium on CST is a spontaneous and endothermic process, with both physical and chemical adsorptions involved.

  18. Some empirical estimates of the H2 formation rate in photon-dominated regions

    Science.gov (United States)

    Habart, E.; Boulanger, F.; Verstraete, L.; Walmsley, C. M.; Pineau des Forêts, G.

    2004-02-01

    We combine recent ISO observations of the vibrational ground state lines of H2 towards Photon-Dominated Regions (PDRs) with observations of vibrationally excited states made with ground-based telescopes in order to constrain the formation rate of H2 on grain surfaces under the physiconditions in the layers responsible for H2 emission. We briefly review the data available for five nearby PDRs. We use steady state PDR models in order to examine the sensitivity of different H2 line ratios to the H2 formation rate R_f. We show that the ratio of the 0-0 S(3) to the 1-0 S(1) line increases with Rf but that one requires independent estimates of the radiation field incident upon the PDR and the density in order to infer Rf from the H2 line data. We confirm earlier work by \\cite{habart2003a} on the Oph W PDR which showed that an H2 formation rate higher than the standard value of 3 × 10-17 cm3 s-1 inferred from UV observations of diffuse clouds is needed to explain the observed H2 excitation. From comparison of the ISO and ground-based data, we find that moderately excited PDRs such as Oph W, S140 and IC 63 require an H2 formation rate of about five times the standard value whereas the data for PDRs with a higher incident radiation field such as NGC 2023 and the Orion Bar can be explained with the standard value of Rf. We compare also the H21-0 S(1) line intensities with the emission in PAH features and find a rough scaling of the ratio of these quantities with the ratio of local density to radiation field. This suggests but does not prove that formation of H2 on PAHs is important in PDRs. We also consider some empirical models of the H2 formation process with the aim of explaining these results. Here we consider both formation on classical grains of size roughly 0.1 μm and on very small (˜10 Å) grains by either direct recombination from the gas phase (Eley-Rideal mechanism) or recombination of physisorbed H atoms with atoms in a chemisorbed site. We conclude that

  19. Spectral resolution of fluxional organometallics. The observation and FTIR characterization of all-terminal [Rh4(CO)12].

    Science.gov (United States)

    Allian, Ayman D; Garland, Marc

    2005-06-07

    In situ FTIR spectroscopy at 1 cm(-1) resolution was conducted on n-hexane solutions of the bridged [Rh4(CO)9(mu-CO)3] in the interval T= 268-288 K and P(T)= 0.1-7.0 MPa using either helium or carbon monoxide as dissolved gas. Analysis of the spectral data sets was conducted using band-target entropy minimization (BTEM), in order to recover the pure component spectra. A new spectral pattern was recovered with terminal vibrations at 2075, 2069.8, 2044.6 and 2042 cm(-1). The new spectrum is consistent with an all-terminal [Rh4(CO)12] species with a C(3v) anticubeoctahedron structure where 2 different [Rh(CO)3] moieties exist, although the presence of some Td structure can not be entirely excluded. The equilibrium between all-terminal [Rh4(CO)12] and the bridged [Rh(4)(CO)9(mu-CO)3] was determined in the presence of both helium and CO. The equilibrium constant K(eq)=[Rh4(CO)12]/[Rh4(CO)9(mu-CO)3] at 275 K was ca. 0.011 and the determined equilibrium parameters were Delta(r)G= 12.63 +/- 4.8 kJ mol(-1), Delta(r)H=-21.45 +/- 2.3 kJ mol(-1) and Delta(r)S=-114.3 +/- 8.35 J mol(-1) K(-1). The free energy indicates a very small difference between the bridged and terminal geometry, and the lower entropy is consistent with a higher symmetry. This finding helps to address a long-standing issue concerning the existence of various [M4(CO)12] symmetries. In a more general context, the present study illustrates the considerable utility of quantitative infrared spectroscopy (occurring on a fast vibrational timescale) combined with sophisticated deconvolution techniques in order to resolve systems which have been demonstrated to be fluxional on the NMR timescale.

  20. Occurrence of Hybrid Escherichia coli Strains Carrying Shiga Toxin and Heat-Stable Toxin in Livestock of Bangladesh

    Science.gov (United States)

    Johura, Fatema-Tuz; Parveen, Rozina; Islam, Atiqul; Sadique, Abdus; Rahim, Md Niaz; Monira, Shirajum; Khan, Anisur R.; Ahsan, Sunjukta; Ohnishi, Makoto; Watanabe, Haruo; Chakraborty, Subhra; George, Christine M.; Cravioto, Alejandro; Navarro, Armando; Hasan, Badrul; Alam, Munirul

    2017-01-01

    Shiga toxin-producing Escherichia coli (STEC) and enterotoxigenic E. coli (ETEC) are important causes of diarrhea in humans and animals worldwide. Although ruminant animals are the main source of STEC, diarrhea due to this pathotype is very low in Bangladesh where ETEC remains the predominant group associated with childhood diarrhea. In the present study, E. coli strains (n = 35) isolated from Bangladesh livestock (goats, sheep, and cattle) and poultry (chicken and ducks) were analyzed for the presence of major virulence factors, such as Shiga toxins (STX-1 and STX-2), heat-labile toxin, and heat-stable toxins (STa and STb). Multiplex polymerase chain reaction results revealed 23 (66%) E. coli strains to be virulent possessing either sta (n = 5), stx (stx1, n = 8; stx2, n = 2), or both (n = 8) genes in varying combinations. Thirty-four percent (8/23) of strains from livestock were hybrid type that carried both stx (either stx1 or stx2) and ETEC-specific enterotoxin gene sta. Serotyping results revealed that the ETEC strains belonged to five serotypes, namely O36:H5, O174:H−, O152:H8, O109:H51, and O8:H21, while the STEC-producing strains belonged to serotypes O76:H19 (n = 3), O43:H2 (n = 2), O87:H16 (n = 2), OR:H2 (n = 1), O110:H16 (n = 1), and O152:H8 (n = 1). The STEC–ETEC hybrid strains belonged to serotypes O76:H19 (n = 3), O43:H2 (n = 2), O87:H16, OR:H2, and O152:H8. Forty percent (2/5) of the ETEC and 20% (2/10) of the STEC strains were multidrug resistant with the highest drug resistance (50%) being found in the hybrid strains. Molecular fingerprinting determined by pulsed-field gel electrophoresis and cluster analyses by dendrogram revealed that, genetically, STEC–ETEC hybrid strains were highly heterogeneous. Multidrug-resistant E. coli STEC–ETEC hybrid strains in domesticated animals pose a public health threat for humans in Bangladesh. PMID:28119905

  1. Molecular structure of kerogens from source rocks of the Tarim Basin: A study by Py-GC-MS and methylation-Py-GC-MS

    Institute of Scientific and Technical Information of China (English)

    JIA; Wanglu; PENG; Ping'an

    2005-01-01

    Flash pyrolysis-gas chromatography-mass spectrometry (Py-GC-MS) and in situ methylation-pyrolysis-gas chromatography-mass spectrometry (methylation-Py-GC-MS) have been employed for a study of molecular structure of kerogens from source rocks of the Tarim Basin. The main products from Py-GC-MS of the Ordovician and Triassic kerogens from the Tarim Basin are n-alkanes and n-alk-1-enes which decrease in relative abundance with increased carbon number. The major products from methylation-Py-GC-MS are normal saturated fatty acid methyl esters which show maxima at C16 and C18. These aliphatic compounds are mainly from lipids of planktonic algae. Moreover, there are more abundant long-chain fatty acids (C20-C26) and normal n-alkanes and n-alk-1-enes (C15-C25) in pyrolysates of Triassic kerogens than that of Ordovician kerogens, reflecting the discrepancies in sources of the Triassic kerogens and the Ordovician kerogens. Besides these aliphatic compounds, methoxyl benzoic acid methyl esters were detected only in products from methylation-Py-GC-MS of late Ordovician kerogen TAC1-1, which possibly was the first molecular evidence for the appearance of moss or other terrestrial plants in the Tarim Basin. In addition, the relative intensity of 17β(H)-trisnorhopane17 β(H),21 α(H)-30-normoretane and 17 β(H)-moretane is lower, but 17α(H)-trisnorhopane and17 α(H)-30-norhopane is higher in the pyrolysates of the Ordovician kerogens in comparison with the pyrolysates of the Triassic kerogens. Moreover, Pr-1-ene has been detected in pyrolysates of Triassic kerogens. These differences in pyrolysates consist with maturity of kerogens. In conclusion, combination of methylation-Py-GC-MS and Py-GC-MS are useful tools to investigate the molecular structure of geomacromolecules and can be subject to type the organic matter, compare the maturity of kerogens and carry out the oil-source correlation.

  2. Balanço de energia em vinhedo de 'Niagara Rosada' Energy balance on 'Niagara Rosada' vineyard

    Directory of Open Access Journals (Sweden)

    José Ricardo Macedo Pezzopane

    2003-01-01

    Full Text Available O método do balanço de energia foi utilizado para caracterizar a variação horária do saldo de radiação e dos fluxos de calor latente, sensível e no solo, em vinhedo cultivado com a cultivar NiagaraRosada', conduzida no sistema de espaldeira, em Jundiaí (SP. Além disso, foram determinadas as relações entre o saldo de radiação (SR no vinhedo e a radiação solar global (RG e a partição da energia disponível ao sistema nos fluxos de calor latente (LE, sensível (H e no solo (G. Em um dia característico de período seco, o LE representou 44% do SR e o H, 48%. Em um dia chuvoso, o LE representou 86% do SR e o H, 21%. Em um dia ensolarado, após um período de chuvas, LE e H foram, respectivamente, 68% e 29% do SR. O G foi, em média, 5,7% e 1,3% do SR para as ruas mantidas capinadas e com forro, respectivamente.The energy balance method was used to characterize the hourly variation of the net radiation, latent and sensible fluxes and soil heat flux on a mature vineyard grown at Jundiaí, São Paulo, Brazil. The grapevines, cv. Niagara Rosada, in the vineyard were wrapped to trellis wires, creating compact hedgerows 2 m apart, 1.7 m height and 0.4 wide, with the foliage 1m above the soil surface. Also, the net and incoming radiation relationships and the partioning of the available energy to the system into latent and heat flux, and soil heat flux were determined for the vineyard. During a sunny day (dry period the latent heat flux was 44% of the net radiation and the sensible heat flux, 48%. However during a rainy day, the latent heat flux was 86% of the net radiation and the sensible heat flux, 21%. During a sunny day, after the occurrence of rain, the latent and sensible heat fluxes were, respectively, 68% and 29% of the net radiation. The soil heat flux was 5.7 an 1.3% of the net radiation, for bare soil and mulched rows, respectively.

  3. Gravity-driven membrane filtration as pretreatment for seawater reverse osmosis: linking biofouling layer morphology with flux stabilization.

    Science.gov (United States)

    Akhondi, Ebrahim; Wu, Bing; Sun, Shuyang; Marxer, Brigit; Lim, Weikang; Gu, Jun; Liu, Linbo; Burkhardt, Michael; McDougald, Diane; Pronk, Wouter; Fane, Anthony G

    2015-03-01

    In this study gravity-driven membrane (GDM) ultrafiltration is investigated for the pretreatment of seawater before reverse osmosis (RO). The impacts of temperature (21 ± 1 and 29 ± 1 °C) and hydrostatic pressure (40 and 100 mbar) on dynamic flux development and biofouling layer structure were studied. The data suggested pore constriction fouling was predominant at the early stage of filtration, during which the hydrostatic pressure and temperature had negligible effects on permeate flux. With extended filtration time, cake layer fouling played a major role, during which higher hydrostatic pressure and temperature improved permeate flux. The permeate flux stabilized in a range of 3.6 L/m(2) h (21 ± 1 °C, 40 mbar) to 7.3 L/m(2) h (29 ± 1 °C, 100 mbar) after slight fluctuations and remained constant for the duration of the experiments (almost 3 months). An increase in biofouling layer thickness and a variable biofouling layer structure were observed over time by optical coherence tomography and confocal laser scanning microscopy. The presence of eukaryotic organisms in the biofouling layer was observed by light microscopy and the microbial community structure of the biofouling layer was analyzed by sequences of 16S rRNA genes. The magnitude of permeate flux was associated with the combined effect of the biofouling layer thickness and structure. Changes in the biofouling layer structure were attributed to (1) the movement and predation behaviour of the eukaryotic organisms which increased the heterogeneous nature of the biofouling layer; (2) the bacterial debris generated by eukaryotic predation activity which reduced porosity; (3) significant shifts of the dominant bacterial species over time that may have influenced the biofouling layer structure. As expected, most of the particles and colloids in the feed seawater were removed by the GDM process, which led to a lower RO fouling potential. However, the dissolved organic carbon in the

  4. Selection and Adsorption Behavior of Resin for the Decaffeination of Tea%脱茶叶咖啡碱树脂的筛选及吸附行为的研究

    Institute of Scientific and Technical Information of China (English)

    王杰; 吴晖

    2012-01-01

    Taking the adsorption rate and adsorption capacity as indexes, the adsorption abilities of 10 kinds of resins were compared and the resin AL-1 was shown to be the best one with its caffeine-adsorption rate of 98.58%. Based on the thermodynamics and kinetics characteristics of the resin AL-1, the change of enthalpy was 21.84 kJ/mol, which indicated that the adsorption was exothermic physical absorption process. The value of free energy was positive and was reduced with the gradual increase of temperature. It indicated that the higher ambient temperature, the more easily caffeine was adsorbed. Equilibrium adsorption data was consistent with both Langmuir and Freundlich isotherms equation, which showed that it was single molecule layer adsorption. A Lagergren pseudo-first order rate equation was suitable to the adsorption process, which was mainly controlled by liquid film.%以茶汤中咖啡碱的吸附率及吸附量为指标,比较了静态吸附条件下10种树脂对茶叶咖啡碱的吸附效果,筛选出吸附效果最佳的树脂AL-1,并对AL-1的吸附热力学及动力学特性进行了研究.结果表明,AL-1对茶叶咖啡碱的吸附率高达98.58%,吸附晗变△H=21.84 kJ/mol,说明AL-1对咖啡碱的吸附是吸热的物理吸附过程,吸附自由能均为正值,且随吸附温度增加而减少,说明环境温度越高,吸附越容易.平衡吸附数据符合Langmuir和Freundlich等温吸附方程,说明吸附属单分子层吸附,吸附速率符合准一级动力学方程,吸附过程主要受液膜控制.

  5. Lack of Male-Female Differences in Disposition and Esterase Hydrolysis of Ramipril to Ramiprilat in Healthy Volunteers after a Single Oral Dose

    Directory of Open Access Journals (Sweden)

    Tom B. Vree

    2003-01-01

    Full Text Available The objective of this study was to identify differences in disposition and esterase hydrolysis of ramipril between male and female volunteers. Plasma concentration and area under the concentration-time curve until the last measured concentration (AUCt data of ramipril and its active metabolite ramiprilat (-diacid were obtained from a randomised, cross-over bioequivalence study in 36 subjects (18 females and 18 males. Participants received a single 5-mg oral dose of two different formulations of ramipril (Formulation I and II. Plasma ramipril and ramiprilat concentrations were determined according to validated methods involving liquid chromatography-mass spectrometry. A total number of 2 � 34 available plasma concentration-time curves of both the parent drug and the metabolite could be analysed, and variations (50�100% coefficient of variation [CV] in plasma concentrations of both parent drug and metabolite were found. With both the formulations, the mean plasma concentrations-time curves of males and females were identical. The groups of female and male volunteers showed similar yields (AUCt = mg.h/L of the metabolite ramiprilat (p = 0.37; however, females showed a higher AUCt/kg than males (p = 0.046. This difference was solely attributed to the difference in body weight between males and females (p = 0.00049. In both male and female groups, a subject-dependent yield of active metabolite ramiprilat was demonstrated, which was independent of the formulation.There is a large variation in the ramiprilat t1/2β (50�60% CV. There is a group of subjects who showed a t1/2β of approximately 80 h (15% CV, and two apparent groups with a longer t1/2βfor each formulation (124 h, 22.5% CV; 166 h, 21.6% CV, respectively, p = 0.0013. This variation in the terminal half-life of ramiprilat is not sex related. In all three groups of half-lives, the corresponding Cmax values (mean � SD of ramiprilat in males and females were identical. Thus, with

  6. A chalcone showing positional disorder, two related diarylcyclohexenones showing enantiomeric disorder and a related hydroxyterphenyl, all derived from simple carbonyl precursors.

    Science.gov (United States)

    Salian, Vinutha V; Narayana, Badiadka; Yathirajan, Hemmige S; Akkurt, Mehmet; Çelik, Ömer; Ersanlı, Cem Cüneyt; Glidewell, Christopher

    2015-07-01

    Four compounds are reported, all of which lie along a versatile reaction pathway which leads from simple carbonyl compounds to terphenyls. (2E)-1-(2,4-Dichlorophenyl)-3- [4-(prop-1-en-2-yl)phenyl]prop-2-en-1-one, C18H14Cl2O, (I), prepared from 4-(prop-1-en-2-yl)benzaldehyde and 2,4-dichloroacetophenone, exhibits disorder over two sets of atomic sites having occupancies of 0.664 (6) and 0.336 (6). The related chalcone (2E)-3-(4-chlorophenyl)-1-(4-fluorophenyl)prop-2-en-1-one reacts with acetone to produce (5RS)-3-(4-chlorophenyl)-5-[4-(propan-2-yl)phenyl]cyclohex-2-en-1-one, C21H21ClO, (II), which exhibits enantiomeric disorder with occupancies at the reference site of 0.662 (4) and 0.338 (4) for the (5R) and (5S) forms; the same chalcone reacts with methyl 3-oxobutanoate to give methyl (1RS,6SR)-4-(4-chlorophenyl)-6-[4-(propan-2-yl)phenyl]-2-oxocyclohex-3-ene-1-carboxylate, C23H23ClO3, (III), where the reference site contains both (1R,6S) and (1S,6R) forms with occupancies of 0.923 (3) and 0.077 (3), respectively. Oxidation, using 2,3-dichloro-5,6-dicyano-1,4-benzoquinone, of ethyl (1RS,6SR)-6-(4-bromophenyl)-4-(4-fluorophenyl)-2-oxocyclohex-3-ene-1-carboxylate, prepared in a similar manner to (II) and (III), produces ethyl 4''-bromo-4-fluoro-5'-hydroxy-1,1':3',1''-terphenyl-4'-carboxylate, C21H16BrFO3, (IV), which crystallizes with Z' = 2 in the space group P-1. There are no significant intermolecular interactions in the structures of compounds (I) and (II), but for the major disorder component of compound (III), the molecules are linked into sheets by a combination of C-H...O and C-H...π(arene) hydrogen bonds. The two independent molecules of compound (IV) form two different centrosymmetric dimers, one built from inversion-related pairs of C-H...O hydrogen bonds and the other from inversion-related pairs of C-H...π(arene) hydrogen bonds. Comparisons are made with related compounds.

  7. Hydrothermal Petroleum in Active Continental Rift: Lake Chapala, Western Mexico, Initial Results.

    Science.gov (United States)

    Zarate-del Valle, P. F.; Simoneit, B. R.; Ramirez-Sanchez, H. U.

    2003-12-01

    Lake Chapala in western Mexico is located partially in the Citala Rift, which belongs to the well-known neotectonic Jalisco continental triple junction. The region is characterized by active volcanism (Ceboruco, Volcan de Fuego), tectonic (1995 earthquake, M=8, 40-50 mm to SW) and hydrothermal (San Juan Cosala & Villa Corona spas and La Calera sinter deposit) activities. Hydrothermal petroleum has been described in active continental rift (East African Rift) and marine spreading zones (Guaymas Basin, Gulf of California). In 1868 the Mexican local press reported that manifestations of bitumen were appearing in front of the Columba Cap on the mid south shore of Lake Chapala. This bitumen is linked to the lake bottom and when the water level decreases sufficiently it is possible to access these tar bodies as islands. Because of these manifestations the Mexican oil company (PEMEX) drilled an exploration well (2,348m) at Tizapan El Alto without success. Hydrothermal activity is evident in the tar island zone as three in-shore thermal springs (26.8 m depth, 48.5° C, pH 7.8 and oriented N-S). The preliminary analyses by GC-MS of the tar from these islands indicate hydrothermal petroleum derived from lake sedimentary organic matter, generated at low temperatures (150° -200° C). The tars contain no n-alkanes, no PAH or other aromatics, but a major UCM of branched and cyclic hydrocarbons and mature biomarkers derived from lacustrine biota. The biomarkers consist of mainly 17α (H),21β (H)-hopanes ranging from C27 to C34 (no C28), gammacerane, tricyclic terpanes (C20-C26), carotane and its cracking products, and drimanes (C14-C16). The biomarker composition indicates an organic matter source from bacteria and algae, typical of lacustrine ecosystems. 14C dating of samples from two tar islands yielded ages exceeding 40 kyrs, i.e., old carbon from hydrothermal/tectonic remobilization of bitumen from deeper horizons to the surface. The occurrence of hydrothermal petroleum in

  8. The Relationship Within Awareness of AIDS Prevention Among MSM, Social Internet and Preventive Service%男男性行为者艾滋病知识知晓与社会网络和预防服务的关系

    Institute of Scientific and Technical Information of China (English)

    王毅; 徐杰; 李志军; 张光贵; 李六林; 樊静

    2011-01-01

    目的 了解男男性行为者(MSM)艾滋病知识知晓现况,分析社会网络及艾滋病预防服务对知晓率的影响.方法 2009 ~ 06/09,采用应答者趋动招募抽样法(RDS),在MSM活动场所定时、定点进行艾滋病防治知识知晓、社会网络、预防服务等情况的招募和寻问式匿名现场调查.结果 共调查400人,艾滋病防治知识平均总知晓率为92.1%,获取知识主要途径互联网62.8%、朋友57.0%、电视44.2%、宣传材料35.3%.不同主要寻找性伴场所者艾滋病防治知识知晓率差异有统计学意义(H=21.254,P<0.01),以联网最高,其次为酒吧/歌舞厅/茶室/会所,以浴室/桑拿/按摩最低,其次是公园/公厕/草地;认识MSM朋友人数与知晓率相关性有统计学意义(rs=0.142,P<0.01),认识朋友多,知晓率相对较高;不同介绍参加调查关系知晓率差异有统计学意义(H=7.905,P<0.05),熟人介绍者最高,其次是好朋友,性伴介绍最低.近半年是否接受过HIV检测、知道检测结果、安全套发放、润湿剂发放、同伴教育、防艾宣传资料发放知晓率差异有统计学意义(Z=- 3.358、-2.308、-3.028、-3.106、- 3.531、-4.019,P<0.05),接受过相应预防性服务者知晓率相对较高;是否以互联网、朋友、宣传材料为主要艾滋病防治知识来源者知晓率差异有统计学意义(Z=-2.754、-3.08、-2.196,P<0.05),以此为主要来源者知晓率较高,为有效宣传来源途径.结论 绵阳市MSM艾滋病防治知识知晓率较高,但不平衡,受社会活动网络、接受艾滋病预防服务因素的影响,应针对性深入开展健康教育,提整体知晓率.%Objective To understand the current situation of AIDS prevention in MSM, analyze the influence by social Internet and AIDS prevention service. Methods During June to September in 2009, recruitment and fieldsurvey about the awareness of AIDS prevention, social Internet and prevention service were conducted

  9. Effects of variations in flow characteristics through W.P. Franklin Lock and Dam on downstream water quality in the Caloosahatchee River Estuary and in McIntyre Creek in the J.N. “Ding” Darling National Wildlife Refuge, southern Florida, 2010–13

    Science.gov (United States)

    Booth, Amanda C.; Soderqvist, Lars E.; Knight, Travis M.

    2016-05-17

    Franklin Lock increases. The highest FDOM recorded during a survey was at Billy’s Creek. Chlorophyll fluorescence was positively correlated with flow at Franklin Lock, with 23 percent of the variation explained by the flow rate at Franklin Lock. An increase in flow rate at Franklin Lock resulted in a decrease in pH (21 percent of variation explained by flow rates). Data from the pH surveys indicate an increase in pH with distance from Franklin Lock. Turbidity and dissolved oxygen near the surface in McIntyre Creek were not correlated with flow rate at Franklin Lock. Moving-boat surveys did not document a change in turbidity or dissolved oxygen with a change in distance from the Franklin Lock. Correlations between Franklin Lock flow rate and water quality in McIntyre Creek indicate that releases at Franklin Lock affect water quality in the Caloosahatchee River Estuary and Ding Darling Refuge.

  10. 人类脂肪来源成体干细胞体外培养的生物学特征研究及供体年龄对其增殖的影响

    Institute of Scientific and Technical Information of China (English)

    雷磊; 廖威明; 盛璞义; 傅明; 何爱珊; 黄纲

    2007-01-01

    通过研究人类脂肪组织来源成体干细胞(human adipose tissue derived adult stem cells,hADAS细胞)体外培养的生物学特征及供体年龄对其生长增殖的影响,为其作为组织工程学研究和应用的种子细胞提供实验室研究基础.取不同年龄组志愿者(<20岁、21~40岁、41~60岁和>61岁),手术中切除少量皮下脂肪组织,酶消化法分离细胞,体外培养,传至20代.取培养第3代细胞,流式细胞仪检测细胞表面抗原标记物(CD29,CD34,CD44,CD45,CD49d,HLA-DR,CD106)和细胞周期.细胞培养传20代后进行细胞染色体组分析.MTT法分别检测各年龄组不同时间点吸光值,绘制生长曲线,根据公式TD=t1g2/1gNt-1gN0换算人类脂肪来源干细胞倍增时间(time doubling,TD).结果显示:酶消化法自皮下脂肪组织分离细胞,体外培养hADAS细胞,流式细胞仪检测示CD29+,CD34-,CD44+,CD45-,CD49d±,HLA-DR-,CD106-;G1期占90%(P10代);P20细胞染色体组分析显示为正常染色体,未见异常染色体,保持遗传稳定.绘制细胞生长曲线,<20年龄组TD为(11.22±0.73)h,21~40年龄组TD为(11.14±0.76)h,两组之间P>0.05,无显著性差异;41~60年龄组TD为(13.18±1.58)h,>61年龄组TD为(13.11±0.83)h,两组之间P>0.05,无显著性差异.<20年龄组TD与>61年龄组TD显著性差异,P<0.05.说明hADAS细胞可方便地取材于皮下脂肪组织,体外培养遗传特性稳定,生长活跃,青年组生长活性强于老年组,可以作为组织工程学种子细胞的新来源.

  11. Avaliação das alterações biomecânicas da córnea antes e após lasik em pacientes míopes e hipermetrópes utilizando Moriá® Sub-Bowman's Keratomileusis (SBK

    Directory of Open Access Journals (Sweden)

    Bruno de Freitas Valbon

    2012-10-01

    Full Text Available OBJETIVO: Avaliar e comparar as alterações biomecânicas da córnea por meio do Ocular Response Analyzer® (ORA Reichert Ophtalmics Instruments, Buffalo, New York, USA antes e após Lasik com Moriá ® Sub Bowman Keratomileusis (SBK One Use Plus (OUP em pacientes míopes e hipermetrópes. MÉTODOS: Foram estudados 33 olhos, sendo 19 olhos míopes e 14 olhos hipermetrópes submetidos à cirurgia refrativa com técnica Lasik com flap fino (100 µ utilizando Moriá SBK OUP. O ORA foi realizado no pré-operatório e 1 mês após a cirurgia para avaliar a biomecânica da córnea. O CH (Corneal Hysteresis, CRF (Corneal Resistance Factor, IOPg (goldmann gold standard, Goldmann correlated intraocular pressure a IOPcc (corneal compensated intraocular pressure e mais 38 variáveis biomecânicas da córnea derivadas do sinal de resposta foram avaliados. O Teste de Kolmogorov-Smirnov foi utilizado para avaliar a distribuição normal. O teste de Wilcoxon foi utilizado para comparar as variáveis antes e após a cirurgia para cada grupo. As diferenças entre as medidas pré e pós-operatórias dos olhos míopes foram comparadas com as diferenças obtidas nos olhos hipermetrópes, utilizando-se o teste de Mann-Whitney. Foi considerado como estatisticamente significante p < 0,05%. RESULTADOS: Houve diferença significativa antes e após Lasik em olhos míopes e hipermetrópes na variável IOPg(Wilcoxon, p <0,05, porém não houve em IOPcc. Somente em olhos míopes houve diferenças significativas em CH e CRF, antes e após Lasik com Moriá SBK OUP, como também 9 parâmetros derivados do ORA Waveform_Sinal Gráfico (aspect1, h1, dive1, path1, p1area1, W11, H11, and w2 path11; Wilcoxon, p <0,05. Em olhos hipermetrópes houve diferenças antes e após Lasik das seguintes variáveis: aspect2, h2, dive2, mslew2 e H21 (Wilcoxon p<0,05.Diferenças nas variáveis IOPg e p1area, antes e após Lasik foram maiores em olhos míopes do que hipermetrópes (Mann-Whitey, p

  12. Influence of Relief on Vegetation Factors and Agrotechnical Differentiation Measures in Transylvania Plain

    Science.gov (United States)

    Ioana Moraru, Paula; Rusu, Teodor; Bogdan, Ileana; Ioan Pop, Adrian

    2016-04-01

    Transylvanian Plain (TP), with an area of 395.616 hectares, has a special importance for Romanian agriculture being characterized as a region orographically represented by hilly areas hills whereas climatically appears as a plain. Physical-geographical conditions from TP (low level of forestation; climate specific to plains) have resulted in numerous land degradation phenomena: land erosion, landslide, draining of gradient springs and groundwater level. These conditions create a favourable framework for the development of anthropic morphogenetic processes, as well as those triggered by natural mechanisms, thus intensifying the pace and their territorial expansion. Rainfall, through annual distribution and spring-summer pluvial aggressiveness, require the implementation of preservation measures on arable land, particularly for spring cultures. Along with rainfall, more factors are involved: relief, by the high degree of fragmentation and through tilting slopes; vegetation, by the dominance of cultivated plants and by the advanced state of degradation of vegetal grasslands (especially on southern slopes); lithology, by the predominance of loose rocks (sand, marl, sandstone etc.). In order to determine the influence of landscape morphology on the agro-technical characterization of land, 11 HOBO Micro Stations (H21-002) have been implemented from April to October in the locality Caianu, at various altitudes (311-441 m) at exposure coverage (N, NW, W, S, SE, E, NE). HOBO Smart Temp (S-TMB-M002) temperature sensors and Decagon EC-5 (S-SMC-M005) moisture sensors were connected to HOBO Micro Stations. Additionally, in 4 of the 11 sites, tipping bucket rain gauges (RG3-M) were deployed to measure precipitation. Each station stored electronic data regarding ground temperature at 3 depths (10, 20, 30 cm), humidity at a depth of 10 cm, air temperature (1 m) and precipitation. Data were downloaded from the Micro Stations via a laptop computer using HOBOware Pro Software Version

  13. Molecular distributions and carbon isotopic compositions of fatty acids in the surface sediments f rom Shenhu Area,northern South China Sea%神狐海域 Si te4 B表层沉积物中脂肪酸组成及其碳同位素分布特征

    Institute of Scientific and Technical Information of China (English)

    朱小畏; 茅晟懿; 吴能友; 孙永革; 管红香

    2013-01-01

    content of them ,the author believes that the surface sediments of the Shenhu area may be embraced by reducing environment . In addition ,eight isoprenoid acids detected in the samples ,mainly phytanic acid and 17β(H) ,21β(H)-32-hopanoic acid ,and a small amount of the pristane acid ,presumably for the joint contribution of chlorophyll A and bacterial microorganisms .

  14. Effects of Fermentation Temperature on Total Acidity and Dominant Microorganisms of Fermented Maize Mash%发酵温度对发酵玉米醪中总酸及主要微生物的影响

    Institute of Scientific and Technical Information of China (English)

    姜照; 杜金华; 孙文涛; 祝敏

    2011-01-01

    In order to provide basis for the production and quality improvement of the sour maize pancake,effects of fermentation temperatures(15,20,25,30,and 35℃) on population of lactic acid bacteria and yeasts,pH value,and total acidity of spontaneously fermented maize mash were investigated;The optimum fermentation time at different temperatures were determined by the total acidity of sour maize pancake.The result showed that with the prolonging of the time,the pH value decreased from 5.62 ~ 6.94 to 3.30 ~ 3.80,and the total acidity increased to 3.89 g/kg ~ 16.14 g/kg.It also showed that the optimum fermentation time were 72~84 h,72~108 h,48~72 h,21~27 h,24~27 h.The lactic acid bacteria and the yeasts co-interacted,and the population of the lactic acid bacteria had the same tendency at the five temperatures,that is,remaining stable and then decreasing slightly after reaching the maximum value.The population of the yeasts reached the maximum and gradually decreased at both 30℃ and 35℃.During fermentation,It is seen that the population of the lactic acid bacteria was obviously more than that of the yeasts.%测定了15、20、25、30、35℃五个温度下自然发酵玉米醪的pH值、总酸含量、乳酸菌及酵母菌数量的变化,研究比较了发酵温度对玉米醪中总酸含量及主要微生物数量的影响,并以玉米酸煎饼的总酸含量为参照,确定了不同温度下的最适发酵时间,以期为玉米酸煎饼的生产及质量的提高提供依据。结果表明,随着发酵时间的延长,pH值由5.62~6.94降低至3.30~3.80;总酸含量增加,初始范围为3.89~16.14 g/kg,最适的发酵时间分别是72~84 h、72~108 h、48~72 h、21~27 h、24~27 h;乳酸菌、酵母菌相互作用,乳酸菌数量5个温度下变化趋势大致相同,达到最大值后保持稳定并略有减少,酵母菌数量在温度较高时(30℃、35℃)达到最大值后逐渐减少,整个发酵过程中,乳酸菌的数量明显多于酵母菌的数量。

  15. A Literature Survey to Identify Potentially Volatile Iodine-Bearing Species Present in Off-Gas Streams

    Energy Technology Data Exchange (ETDEWEB)

    Bruffey, S. H. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Spencer, B. B. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Strachan, D. M. [Strata-G, Knoxville, TN (United States); Jubin, R. T. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Soelberg, N. R. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Riley, B. J. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2015-06-30

    Four radionuclides have been identified as being sufficiently volatile in the reprocessing of nuclear fuel that their gaseous release needs to be controlled to meet regulatory requirements (Jubin et al. 2011, 2012). These radionuclides are 3H, 14C, 85Kr, and 129I. Of these, 129I has the longest half-life and potentially high biological impact. Accordingly, control of the release of 129I is most critical with respect to the regulations for the release of radioactive material in stack emissions. It is estimated that current EPA regulations (EPA 2010) would require any reprocessing plant in the United States to limit 129I release to less than 0.05 Ci/MTIHM for a typical fuel burnup of 55 gigawatt days per metric tonne (GWd/t) (Jubin 2011). The study of inorganic iodide in off-gas systems has been almost exclusively limited to I2 and the focus of organic iodide studies has been CH3I. In this document, we provide the results of an examination of publically available literature that is relevant to the presence and sources of both inorganic and organic iodine-bearing species in reprocessing plants. We especially focus on those that have the potential to be poorly sequestered with traditional capture methodologies. Based on the results of the literature survey and some limited thermodynamic modeling, the inorganic iodine species hypoiodous acid (HOI) and iodine monochloride (ICl) were identified as potentially low-sorbing iodine species that could present in off-gas systems. Organic species of interest included both short chain alkyl iodides such as methyl iodide (CH3I) and longer alkyl iodides up to iodododecane (C10H21I). It was found that fuel dissolution may provide conditions conducive to HOI formation and has been shown to result in volatile long-chain alkyl iodides, though these may not volatilize until later in the reprocessing sequence. Solvent extraction processes were found to be significant sources of various organic iodine-bearing species; formation of these

  16. EXPRESSION OF △Np63 AND MDM2 PROTEINS IN TRANSITIONAL CELL CARCINOMA OF URINARY BLADDER%膀胱移行细胞癌组织△Np63和MDM2蛋白表达及意义

    Institute of Scientific and Technical Information of China (English)

    张鲁伟; 周荣祥

    2007-01-01

    目的 探讨缺乏酸性N端反式激活区的截短型p63(△Np63)和MDM2蛋白在膀胱移行细胞癌(TCC)组织中的表达及其临床意义.方法 用免疫组织化学法,检测35例石蜡包埋TCC组织标本中△Np63和MDM2的表达,以38例正常膀胱黏膜作为对照.结果 膀胱癌组30例(83.3%)△Np63蛋白呈阳性表达,膀胱黏膜组7例(18.4%)呈阳性表达,两组比较差异有显著性(uc=5.75,P<0.01).膀胱癌组15例(42.9%)MDM2蛋白呈阳性表达,膀胱黏膜组3例(7.9%)呈阳性表达,两组差异有显著性(x2=11.99,P<0.01).在不同病理分级、临床分期TCC中,△Np63表达差异有显著性(H=21.09、14.99,P<0.01).随着TCC病理分级、临床分期升高,△Np63表达明显增强,呈显著正相关(r=0.64、0.51,P<0.01).在不同病理分级、临床分期TCC中,MDM2表达差异有显著性(x2=16.63,P<0.01;x2=6.72,P<0.05).30例△Np63蛋白阳性表达TCC组织中MDM2蛋白阳性表达10例(33.3%),两者呈显著相关性(x2=7.78,P<0.05).△Np63阳性表达主要集中在低分化、浸润性TCC中,而MDM2则主要表达在高分化、浅表TCC中.结论 △Np63和MDM2与膀胱肿瘤的发生发展密切相关,可作为膀胱肿瘤早期诊断和判断恶性程度的参考指标.

  17. Automation of Eastern Kentucky University Observatory and Preliminary Data

    Science.gov (United States)

    Ciocca, M.; Kilgore, E. E.; Williams, W. W.

    2012-06-01

    (Abstract only) Eastern Kentucky University is a regional comprehensive institution located in Richmond, Kentucky. Its service area includes much of the eastern part of Kentucky, commonly referred to as Appalachia. As such, Eastern has truly been a "school of opportunities" for the region. We offer three astronomy courses and one of them, AST 135, has an outdoor lab component, in which the students observe the moon and the brightest planets using 6-inch SCT. To expand our offerings by adding advanced classes in observational astronomy, and with support from the University and a small grant from the AAS (Small Research Grants), we constructed a small observatory for that purpose. We have a 14-inch telescope (C14 from Celestron), with a research grade mount (Paramount ME), housed permanently in a two-room facility. The telescope room has a retractable roof and the control room is insulated against the elements. The telescope is conveniently located near campus, in a location away from city lights and vehicular traffic, with access via a secure gate. The observatory is on a concrete pad poured directly onto the ground, to minimize vibrations. The instrument package consists of a SBIG STL-6303E CCD camera with filter wheel and full complement of photographic, narrow-band, and photometric filters (Ha and UBVRI). Courtesy of the AAS grant, we also have a temperature-compensated focuser (TCF-S3i), off-axis guider, and SBIG AO-L adaptive optics accessory. Our first step has been the measurement of our CCD transformation parameters, to assess the capabilities of our telescope-camera combination. We imaged a standard photometric field from Landolt (1992) (R.A. 09h 21m 32s, Dec. +02° 47' 00" (J2000, Plate 38 of Landolt). Data were obtained with a time integration of 90 seconds, binned 2 x 2 (~1 arcsec/pixel) at air mass X = 1.31. We determined the CCD transformation parameter as described by the AAVSO document "Computing and Using CCD transformation coefficients" (Cohen 2003

  18. p53凋亡刺激蛋白2对饥饿诱导的大肠癌HCT116 p53-/-细胞自噬和凋亡的影响%The role of ASPP2 in starvation-induced autophagy and apoptosis of HCT116 cell line

    Institute of Scientific and Technical Information of China (English)

    侯庆生; 丁谓; 陈德喜; 张玉林; 郭洪亮

    2013-01-01

    目的 探讨p53凋亡刺激蛋白2(apoptosis stimulating protein 2 0f p53,ASPP2)对饥饿诱导的大肠癌HCT116 p53-/-(p53缺失)细胞自噬和凋亡的影响.方法 实验分3组:(1)绿色荧光蛋白腺病毒(green fluorescent protein adenovirus,rAd-GFP)感染组(对照组);(2)自噬抑制剂LY294002处理组;(3) ASPP 2腺病毒(ASPP2 adenovirus,rAd-ASPP2)感染组.无血清培养基分别培养0、24、48 h诱导细胞自噬和凋亡.利用calcein/PI吸收试验观察各组细胞凋亡水平.细胞转染红色荧光蛋白自噬质粒Lc3(cerise fluorescent protein autophagy plasmid Lc3,CFP-Lc3),在荧光显微镜下观察各组细胞自噬水平.结果 rAd-GFP感染组饥饿24h细胞的自噬水平升高显著(0 h:1.04±0.24;24 h:12.17 ±0.86,P<0.05),而凋亡水平改变差异无统计学意义(0 h:2.01%±0.06%;24 h:3.23%±0.34%,P>0.05);饥饿时间延长至48 h,自噬水平(0 h:1.04±0.24;48 h:21.09±3.32)和凋亡水平(0h:2.01%±0.06%;48 h:30.20%±3.18%)升高,差异均具有统计学意义(均P<0.05).使用LY294002抑制细胞自噬,饥饿24 h细胞凋亡显著增多(rAd-GFP组:3.23%±0.34%;LY294002组:15.68%±1.24%,P<0.01),而饥饿48 h凋亡显著减少(rAd-GFP组:30.20%±3.18%;LY294002组:25.44%±3.01%,P <0.05).rAd-ASPP2感染组饥饿24 h自噬显著降低(rAd-GFP组:12.17±0.86;ASPP2组:1.45±0.45,P<0.01),而凋亡显著升高(rAd-GFP组:3.23%±0.34%;ASPP2组:10.45% ±0.81%,P<0.05);饥饿48 h自噬(rAd-GFP组:21.09 ±3.32;ASPP2组:29.93±3.48)和凋亡(rAd-GFP组:30.20%±3.18%;ASPP2组:36.72%±2.74%)水平均显著升高(均P<0.05).结论 ASPP2通过对自噬的双向调节促进饥饿诱导的大肠癌HCT116 p53-/-细胞凋亡.%Objective To investigate the role of ASPP2 (apoptosis stimulating protein 2 of p53,ASPP2) in starvation-induced autophagy and apoptosis of colorectal cancer HCT116 p53-/-(p53 gene deletion) cell line.Methods The study included three

  19. Application of sodium citrate combined with modified dialysate in continuous venous-venous hemodialysis%枸橼酸钠抗凝联合透析液配方改良在连续性静脉-静脉血液透析中的应用

    Institute of Scientific and Technical Information of China (English)

    兰洋; 齐华林; 庄守纲; 严海东

    2012-01-01

    析液流量、血流量、4%枸橼酸钠和氯化钙流量.记录患者动脉血气、外周血及透析器后游离钙离子浓度、血浆总钙浓度、管路和滤器的凝血情况和使用时间,观察治疗中的不良反应.结果 在血液透析过程中两组患者生命体征平稳,无1例患者发生抽搐、痉挛等明显低钙血症的表现.RCA组的滤器使用时间为(74±42)h,显著长于肝素组的(32士26)h(P<0.01).22例(56.4%)患者发生代谢性碱中毒,通过增加透析液流量250~500 mL/h,21例(95.5%)患者在48 h内达到酸碱平衡.结论 枸橼酸钠抗凝联合血液透析液处方改良应用在AKI合并活动性或高危出血患者行CVVHD时,既不加重患者出血倾向,又能够达到临床治疗效果.

  20. Characterization of seed oils from different varieties of watermelon [Citrullus lanatus (Thunb.] from Pakistan

    Directory of Open Access Journals (Sweden)

    Mahmood, Z.

    2012-10-01

    Full Text Available This paper reports the physicochemical characteristics of the seed oils from different varieties of watermelon (Citrullus lanatus cultivated in Pakistan, namely Sugar Baby, Q-F-12, D-W-H-21 and Red Circle-1885. The oil and crude protein contents from watermelon seeds, within the range of 28.25 to 35.65% and 20.50 to 35.00%, respectively, varied significantly (p -1 of oil, saponification index (190.20-205.57 mg KOH g-1 of oil, unsaponifiable matter (0.54-0.82% and color (1.12-4.30 R + 12.20-33.40 Y. The oils revealed a reasonable oxidative parameter range as depicted by the determinations of specific extinction at 232 and 270 nm (2.90-4.40 and 2.05- 3.09, respectively, p-anisidine value (5.60-7.70 and peroxide value (2.90-5.06 meqO2 kg-1 of oil. Linoleic acid was the major fatty acid found in all the seed oils with contributions of 45.30-51.80% of the total fatty acids (FA. Other fatty acids detected were known to be oleic acid (20.2- 23.5%, palmitic acid (15.1-16.9% and stearic acid (11.5- 14.4%. The contents of α- and δ-tocopherol in the oils accounted for 120.6-195.6 and 9.1-58.3 mg kg-1, respectively. The physicochemical attributes of the watermelon seed oils showed a wider variation among the varieties tested. The results of the present study indicate that the seeds of the tested watermelon varieties from Pakistan are a potential source of high-linoleic oil and thus can be explored for commercial use and value addition.Se presentan las características físico-químicas de aceites de diferentes variedades de semillas de sandías (Citrullus lanatus cultivadas en Pakistán: Sugar Baby, QF-12, DWH-21 y Círculo rojo-1885. El aceite y el contenido de proteína cruda de las semillas de sandía están dentro de los rangos: 28,25-35,65% y 20,50-35,00%, respectivamente y varian significativamente (p -1 de aceite, índice de saponificación (190,20-205,57 mg de KOH g-1 de aceite, insaponificable (0,54-0.82% y color (1.12-4.30 de I + 12.20- 33.40 y