zebrafish embryonic development: Topics by WorldWideScience.org

Effects of Licorice on Embryonic and Fetal Development in Rats

BackgroundMutations that disrupt the conversion of prelamin A to mature lamin A cause the rare genetic disorder Hutchinson-Gilford progeria syndrome and a group of laminopathies....Full Text Available

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Cadmium inhibits neurogenesis in zebrafish embryonic brain development

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2005-12-01

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Construction and Application of a Zebrafish Array CGH Platform

Cadmium is a non-essential heavy metal found abundantly in the environment. Children of women exposed to cadmium during pregnancy display lower motor and perceptual abilities. High cadmium body burden in children is also related to impaired intelligence and lowered school achievement. However, little is known about the molecular and cellular basis of developmental neurotoxicity in the sensitive early life stages of animals. In this study, we explore neurological deficits caused by cadmium during early embryonic stages in zebrafish by examining regionalization of the neural tube, pattern formation and cell fate determination, commitment of proneural genes and induction of neurogenesis. We show that cadmium-treated embryos developed a smaller head with unclear boundaries between the brain subdivisions, particularly in the mid-hindbrain region. Embryos display normal anterior to posterior regionalization; however, the ...

2008-05-01

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Molecular cloning of the human homeobox gene goosecoid (GSC) and mapping of the gene to human chromosome 14q32. 1

The zebrafish is emerging as a prominent model system for studying the genetics of human development and disease. Genetic alterations that underlie each mutant model can exist in the form of...Full Text Available

2009-02-01

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Purpurin is a key molecule for cell differentiation during the early development of zebrafish retina

Goosecoid is a homeobox gene first isolated from a Xenopus dorsal lip cDNA library. Homologous genes have been isolated from mouse, zebrafish, and chick. In all species examined, the gene is expressed and plays an important role during the process of gastrulation in early embryonic development. The authors report here the cloning of the human goosecoid (GSC) from a genomic library and the sequence of its encoded protein. The genomic organization and protein sequence of the human gene are highly conserved with respect to those of its Xenopus and mouse counterparts: all three genes consist of three exons, with conserved exon-intron boundaries. The sequence of the homeo-domain is 100% conserved in most vertebrates. Using somatic cell hybrid and chromosomal in situ hybridization, the gene was mapped to chromosome 14q32.1. 30 refs., 3 figs., 2 tabs.

1994-05-15

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British Library Electronic Table of Contents (United Kingdom)

Recently, we cloned purpurin cDNA as an upregulated gene in the axotomized fish retina. The retina-specific protein was secreted from photoreceptors to ganglion cell layer during an early stage of optic nerve regeneration in zebrafish retina. The purpurin worked as a trigger molecule for axonal regrowth in adult injured fish retina. During zebrafish development, purpurin mRNA first appeared in ventral retina at 2 days post-fertilization (dpf) and spread out to the outer nuclear layer at 3 dpf. Here, we investigated the role of purpurin for zebrafish retinal development using morpholino gene knockdown technique. Injection of purpurin morpholino into the 1-2 cell stage of embryos significantly inhibited the transcriptional and translational expression of purpurin at 3 dpf. In the purpurin mo...

2009-01-01

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nkx2.2a promotes specification and differentiation of a myelinating subset of oligodendrocyte lineage cells in zebrafish

misty somites, a maternal effect gene identified by transposon-mediated insertional mutagenesis in zebrafish that is essential for the somite boundary maintenance

During development, multipotent neural precursors give rise to oligodendrocyte progenitor cells (OPCs), which migrate and divide to produce additional OPCs. Near the end of embryogenesis and...Full Text Available

2008-05-01

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Myofibrillogenesis in the developing zebrafish heart: A functional study of tnnt2

Somite boundary formation is crucial for segmentation of vertebrate somites and vertebrae and skeletal muscle morphogenesis. Previously, we developed a Tol2 transposon-mediated...Full Text Available

2008-04-15

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Knockdown of Bicaudal C in Zebrafish (Danio rerio) Causes Cystic Kidneys: A Nonmammalian Model of Polycystic Kidney Disease

Various hypotheses have been proposed to explain the molecule processes of sarcomere assembly, partially due to the lack of systematic genetic studies of sarcomeric genes in an in vivo...Full Text Available

2009-07-15

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Identification of a distant cis-regulatory element controlling pharyngeal arch-specific expression of zebrafish gdf6a/radar

Polycystic kidney disease (PKD) is one of the leading causes of end-stage renal disease in humans and is characterized by progressive cyst formation, renal enlargement, and abnormal tubular development....Full Text Available

2010-04-01

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A highly conserved regulatory element controls hematopoietic expression of GATA-2 in zebrafish

Skeletal formation is an essential and intricately regulated part of vertebrate development. Humans and mice deficient in Growth and Differentiation Factor 6 (Gdf6) have numerous...Full Text Available

2010-04-01

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Neural Tissues from the Implanted Stem Cells

BackgroundGATA-2 is a transcription factor required for hematopoietic stem cell survival as well as for neuronal development in vertebrates. It has been shown that specific expression...Full Text Available

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Bioengineering the Hair Follicle

Morphological, Electrophysiological and Behavioral Investigations of the Nervous Tissue Developed from the Embryonic Matrix Zone Cells of the Dorsolateral Walls of Lateral Ventricles, Implanted into the Lesioned Regions of the Adult Rat's Brain

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Cryopreservation of isolated blastomeres and embryonic stem-like cells of Leopard danio, Brachydanio frankei

The hair follicle develops from the primitive embryonic epidermis as a result of complex epithelial-mesenchymal interactions. The full follicle, consisting of epithelial cylinders under control of a...Full Text Available

2007-01-01

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British Library Electronic Table of Contents (United Kingdom)

Abstract This study aimed at developing a suitable cryopreservation protocol for embryonic stem (ES)-like cells of a tiny freshwater fish Leopard danio (Brachydanio frankei). Embryonic stem (ES)-like cells derived from blastomeres of the early blastulae stage of the developing embryo were cultured in vitro in a medium containing Leibowitz-15 supplemented with 10% foetal bovine serum, leopard danio embryo extract, sodium bicarbonate, sodium selenite, basic fibroblast growth factor, epidermal growth factor and leukaemia inhibitory factor. The ES-like cells showed properties similar to ES cells in other species. They were morphologically small, round to polygonal and present in patches and extensively expressed alkaline phosphatase and stage-specific embryonic antigen. The toxicity and chilli...

2010-01-01

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Mutations affecting the development of the peripheral nervous system in Drosophila: a molecular screen for novel proteins.

Production and Characterization of Monoclonal Antibodies to Mouse Germ Cells

In our quest for novel genes required for the development of the embryonic peripheral nervous system (PNS), we have performed three genetic screens using MAb 22C10 as a marker of terminally differentiated...Full Text Available

2000-12-01

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British Library Electronic Table of Contents (United Kingdom)

In mammals, primordial germ cells (PGCs) are generated in the extra-embryonic epiblast, and thereafter migrate into the developing gonads. Following the development of the gonads to the testes or ovaries, germ cells mature into sperms or eggs. In the present study, we report production and characterization of monoclonal antibodies (MAb) that recognize PGCs. Extracts from E12.5 mouse embryonic gonads were immunized as an antigen, and hybridomas were generated using the rat medial iliac lymph node method. The hybridoma supernatants were screened by immunohistochemical analyses of E12.5 mouse embryonic sections. The antibody, referred to herein as MAb 5B5, provided strong signals on PGCs. Moreover, immunofluorescence analyses using a variety of the tissue sections of mouse embryos revealed th...

2010-01-01

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Steroid hormones and brain development: some guidelines for understanding actions of pseudohormones and other toxic agents.

Stem Cell Research (Updated July 26, 2002).

Gonadal, adrenal, and thyroid hormones affect the brain directly, and the sensitivity to hormones begins in embryonic life with the appearance of hormone receptor sites in discrete populations of neurons....Full Text Available

1987-10-01

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Sonic hedgehog controls growth of external genitalia by regulating cell cycle kinetics

Embryonic stem cells have the ability to develop into virtually any cell in the body, and may have the potential to treat medical conditions such as diabetes and Parkinsons disease. On August 9, 2001, President Bush announced that for the first time feder...

2002-01-01

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Severe teratozoospermia and its influence on pronuclear morphology, embryonic cleavage and compaction

During embryonic development, cells are instructed which position to occupy, they interpret these cues as differentiation programmes, and expand these patterns by growth. Sonic hedgehog...Full Text Available

2010-06-01

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STIMPY mediates cytokinin signaling during shoot meristem establishment in Arabidopsis seedlings

BackgroundFertilization, cell division and embryo development depend on genomic contributions from male and female gametes. We hypothesize that teratozoospermic sperm influences...Full Text Available

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Propagation of human embryonic and induced pluripotent stem cells in an indirect co-culture system

The establishment of the primary meristems through proliferation after germination is essential for plant post-embryonic development. Cytokinins have long been considered a key regulator of...Full Text Available

2010-02-15

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A gene expression signature shared by human mature oocytes and embryonic stem cells

We have developed and validated a microporous poly(ethylene terephthalate) membrane-based indirect co-culture system for human pluripotent stem cell (hPSC) propagation, which allows real-time...Full Text Available

2010-03-05

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Defective Glycinergic Synaptic Transmission in Zebrafish Motility Mutants

BackgroundThe first week of human pre-embryo development is characterized by the induction of totipotency and then pluripotency. The understanding of this delicate process will have...Full Text Available

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Assessing the risk of ovarian hyperstimulation syndrome in egg donation: implications for human embryonic stem cell research.

Glycine is a major inhibitory neurotransmitter in the spinal cord and brainstem. Recently, in vivo analysis of glycinergic synaptic transmission has been pursued in zebrafish using...Full Text Available

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In vitro differentiation of rat embryonic stem cells into functional cardiomyocytes

Stem cell research has important implications for medicine. The source of stem cells influences their therapeutic potential, with stem cells derived from early-stage embryos remaining the most versatile. Somatic cell nuclear transfer (SCNT), a source of embryonic stem cells, allows for understandings about disease development and, more importantly, the ability to yield embryonic stem cell lines that are genetically matched to the somatic cell donor. However, SCNT requires women to donate eggs, which involves injection of ovulation-inducing hormones and egg retrieval through laparoscopy or transvaginal needle aspiration. Risks from this procedure are fiercely debated, most notably risk of ovarian hyperstimulation syndrome (OHSS). This review examines risk of OHSS resulting from oocyte donation. We conclude that risk posed by OHSS in egg donation is not significant enough to warrant undue concern, and much of this can be ...

2011-09-01

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British Library Electronic Table of Contents (United Kingdom)

The recent breakthrough in the generation of rat embryonic stem cells (rESCs) opens the door to application of gene targeting to create models for the study of human diseases. In addition, the in vitro differentiation system from rESCs into derivatives of three germ layers will serve as a powerful tool and resource for the investigation of mammalian development, cell function, tissue repair, and drug discovery. However, these uses have been limited by the difficulty of in vitro differentiation. The aims of this study were to establish an in vitro differentiation system from rESCs and to investigate whether rESCs are capable of forming terminal-differentiated cardiomyocytes. Using newly established rESCs, we found that embryoid body (EB)-based method used in mouse ESC (mESC) differentiation...

2011-01-01

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Developing defined culture systems for human pluripotent stem cells

British Library Electronic Table of Contents (United Kingdom)

Human pluripotent stem cells hold promising potential in many therapeutics applications including regenerative medicine and drug discovery. Over the past three decades, embryonic stem cell research has illustrated that embryonic stem cells possess two important and distinct properties: the ability to continuously self-renew and the ability to differentiate into all specialized cell types. In this article, we will discuss the continuing evolution of human pluripotent stem cell culture by examining requirements needed for the maintenance of self-renewal in vitro. We will also elaborate on the future direction of the field toward generating a robust and completely defined culture system, which has brought forth collaborations amongst biologists and engineers. As human pluripotent stem cell re...

2011-01-01

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PRELIMINARY STUDY ON MODIFICATION OF YOLK SAC OF ZEBRAFISH EMBRYOS (DANIO RERIO) USING MICROINJECTION

Molecular conservation of estrogen-response associated with cell cycle regulation, hormonal carcinogenesis and cancer in zebrafish and human cancer cell lines

Low membrane permeability is one of the major obstacles to the successful cryopreservation of zebrafish embryos. The aim of the present study was to explore if this could be overcome by yolk...Full Text Available

2006-01-01

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Duplication and Diversification of the Hypoxia-Inducible IGFBP-1 Gene in Zebrafish

BackgroundThe zebrafish is recognized as a versatile cancer and drug screening model. However, it is not known whether the estrogen-responsive genes and signaling pathways that are...Full Text Available

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Analysis of the astray/robo2 zebrafish mutant reveals that degenerating tracts do not provide strong guidance cues for regenerating optic axons

BackgroundGene duplication is the primary force of new gene evolution. Deciphering whether a pair of duplicated genes has evolved divergent functions is often challenging. The zebrafish...Full Text Available

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Quox-1, a quail homeobox gene expressed in the embryonic central nervous system, including the forebrain.

During formation of the optic projection in astray/robo2 mutant zebrafish, optic axons exhibit rostro-caudal pathfinding errors, ectopic midline crossing and...Full Text Available

2010-10-13

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Influence of chromatin molecular changes on RNA synthesis during embryonic development

This paper reports the cloning and sequencing of a quail homeobox-containing gene, Quox-1, and its expression pattern in embryos from 3 to 6 days (E3 to E6) of development as determined by in situ hybridization....Full Text Available

1991-03-15

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The neural basis of visual behaviors in the larval zebrafish

Two aspects of the chromatin repeat length (r_l) are discussed: (i) Why is r_l longer for slowly dividing cells than in rapidly dividing cells?, and (ii) Why is the temporal evolution of r_l a decreasing function of time (t) in mammalian cortical neurons whereas it is an increasing function of t for granule cells around the time of birth? These questions are discussed in terms of a hypothesis which assumes a correlation between deoxyribonucleic acid (DNA) packaging, transcription, and replication. (author). 27 refs.

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British Library Electronic Table of Contents (United Kingdom)

We review visually guided behaviors in larval zebrafish and summarise what is known about the neural processing that results in these behaviors, paying particular attention to the progress made in the last 2 years. Using the examples of the optokinetic reflex, the optomotor response, prey tracking and the visual startle response, we illustrate how the larval zebrafish presents us with a very promising model vertebrate system that allows neurocientists to integrate functional and behavioral studies and from which we can expect illuminating insights in the near future.

2009-01-01

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The mouse formin (Fmn) gene: Genomic structure, novel exons, and genetic mapping

Final report of the specific research. Investigations on the analysis of bio-protective factors against radiation. 1998-2000 FY (Research Group of NIRS)

Mutations in the mouse formin (Fmn) gene, formerly known as the limb deformity (ld) gene, give rise to recessively inherited limb deformities and renal malformations or aplasia. The Fmn gene encodes many differentially processed transcripts that are expressed in both adult and embryonic tissues. To study the genomic organization of the Fmn locus, we have used Fmn probes to isolate and characterize genomic clones spanning 500 kb. Our analysis of these clones shows that the Fmn gene is composed of at least 24 exons and spans 400 kb. We have identified two novel exons that are expressed in the developing embryonic limb bud as well as adult tissues such as brain and kidney. We have also used a microsatellite polymorphism from within the Fmn gene to map it genetically to a 2.2-cM interval between D2Mit58 and D2Mit103. 36 refs., 6 figs., 1 tab.

1997-02-01

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Development of a novel mouse tk{sup +/-} embryonic stem cell line for use in mutagenicity studies

This report concerns investigations in the title conducted by 8 groups of National Institute of Radiological Sciences (NIRS) during the period of 1998-2000. The groups are for investigation of: Effects of p53 tumor suppressor gene in radiation-induced leukemia, Role of atm-gene in dose rate effect of ionizing radiation, Function of DNA-dependent protein kinase catalytic subunit (DNA-PK{sub cs}), Functional complementation of radiation-sensitive mutant M10 cell line by human XRCC4 cDNA expression, Role of radiation-induced apoptosis in digital defects in embryonic mice, Functional analysis of S-phase specific novel nuclear protein NP95 by gene targeting, Role of chemokine in T cell development and lymphomagenesis, and establishment of production techniques of gene-modified mice using embryonic stem cells for genetic analysis of radiation-sensitive genes. The groups describe summaries of their studies and published original ...

2002-03-01

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Visual acuity in larval zebrafish: behavior and histology

A tk{sup +/-} mouse embryonic stem (ES) cell line, designated 1G2, has been created in which one allele of the thymidine kinase (tk) gene was inactivated by targeted homologous recombination. This line is an analog of the mouse lymphoma tk{sup +/-} L5178Y cell line, which is used widely to assess the mutagenicity of chemical agents. Treatment of 1G2 cells with the alkylating agent N-ethyl-N-nitrosourea (ENU) resulted in a dose-related increase in tribluorothymidine-resistant colonies. Mutant frequencies of 152 and 296 per 10{sup 6} cells were determined for 0.1 and 0.3 mg/ml doses of ENU, compared with a spontaneous mutant frequency of 15 per 10{sup 6} cells. The data indicate that tk{sup +/-} 1G2 ES cells may be useful for the creation of a transgenic mouse model for assessing in vivo mutation using an endogenous autosomal gene. 45 refs., 2 figs., 1 tab.

1996-12-31

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Early development of the digestive tract (pharynx and gut) in the embryos and pre-larvae of the European sea bass Dicentrarchus labrax

BackgroundVisual acuity, the ability of the visual system to distinguish two separate objects at a given angular distance, is influenced by the optical and neuronal properties of...Full Text Available

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British Library Electronic Table of Contents (United Kingdom)

The European sea bass Dicentrarchus labrax is a marine teleost important in Mediterranean aquaculture. The development of the entire digestive tract of D. labrax, including the pharynx, was investigated from early embryonic development to day 5 post hatching (dph), when the mouth opens. The digestive tract is initialized at stage 12 somites independently from two distinct infoldings of the endodermal sheet. In the pharyngeal region, the anterior infolding forms the pharynx and the first gill slits at stage 25 somites. The other three gill arches and slits are formed between 1 and 5 dph. Posteriorly, in the gut tube region, a posterior infolding forms the foregut, midgut and hindgut. The anus opens before hatching, at stage 28 somites. Associated organs (liver, pancreas and gall bladder) ar...

2009-01-01

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Expression of embryonic hemoglobin genes in. cap alpha. -thalassemic and in. beta. -duplication mice

Abrogation of E-Cadherin-Mediated Cellular Aggregation Allows Proliferation of Pluripotent Mouse Embryonic Stem Cells in Shake Flask Bioreactors

The results of a study of the expression of embryonic hemoglobin genes in mice which show an imbalance of alpha and non-alpha chain synthesis are reported. (ACR)

1979-01-01

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The Pan 13th Annual Forum

BackgroundA fundamental requirement for the exploitation of embryonic stem (ES) cells in regenerative medicine is the ability to reproducibly derive sufficient numbers of cells of...Full Text Available

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Different telomere-length dynamics at the inner cell mass versus established embryonic stem (ES) cells

... Exposure Treatment Research Program (NETRP); and a panel of doctors and researchers who will discuss Embryonic Stem Cell Research. ...

2007-11-01

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Side effects of grain protectants on biological control agents: How Hyptis plant extracts affect parasitism and larval development of Dinarmus basalis

Murine embryonic stem (ES) cells have unusually long telomeres, much longer than those in embryonic tissues. Here we address whether hyper-long telomeres are a natural property of pluripotent stem cells,...Full Text Available

2011-09-13

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British Library Electronic Table of Contents (United Kingdom)

Dinarmus basalis Rondani (Hymenoptera: Pteromalidae), an ectoparasitoid of bruchid pests of stored cowpeas (Vigna unguiculata), is a potential biological control agent. We investigated whether grain protectants from Hyptis spicigera and H. suaveolens (Lamiaceae) disturb parasitism and post-embryonic growth of the parasitoid. When cowpeas containing bruchid larvae were treated before being placed in the presence of D. basalis females, the rate of parasitism decreased on average up to 24% and 47% in the presence of, respectively, leaf dry powder and essential oils from both plant species. The estimated larval mortality was higher on treated (9.55 to 28.6%) than on non-treated parasitized hosts (2.8%), depending on the plant species and the plant extract tested. Additional larval mortality wa...

2011-01-01

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Cell-mediated mutagenesis and cell transformation of mammalian cells by chemical carcinogens. [Rats, hamsters

Ionizing radiation is a potent inducer of mitotic recombination in mouse embryonic stem cells

We have developed a cell-mediated mutagenesis assay in which cells with the appropriate markers for mutagenesis are co-cultivated with either lethally irradiated rodent embryonic cells that can metabolize carcinogenic hydrocarbons or with primary rat liver cells that can metabolize chemicals carcinogenic to the liver. During co-cultivation, the reactive metabolites of the procarcinogen appear to be transmitted to the mutable cells and induce mutations in them. Assays of this type make it possible to demonstrate a relationship between carcinogenic potency of the chemicals and their ability to induce mutations in mammalian cells. In addition, by simultaneously comparing the frequencies of transformation and mutation induced in normal diploid hamster cells by benzo(a)pyrene (BP) and one of its metabolites, it is possible to estimate the genetic target size for cell transformation in vitro.

1977-01-01

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British Library Electronic Table of Contents (United Kingdom)

Maintenance of genomic integrity in embryonic cells is pivotal to proper embryogenesis, organogenesis and to the continuity of species. Cultured mouse embryonic stem cells (mESCs), a model for early embryonic cells, differ from cultured somatic cells in their capacity to remodel chromatin, in their repertoire of DNA repair enzymes, and in the regulation of cell cycle checkpoints. Using 129XC3HF1 mESCs heterozygous for Aprt, we characterized loss of Aprt heterozygosity after exposure to ionizing radiation. We report here that the frequency of loss of heterozygosity mutants in mESCs can be induced several hundred-fold by exposure to 5-10Gy of X-rays. This induction is 50-100-fold higher than the induction reported for mouse adult or embryonic fibroblasts. The primary mechanism underlying the...

2011-01-01

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Zebrafish embryo extracts promote sphere-forming abilities of human melanoma cell line

British Library Electronic Table of Contents (United Kingdom)

Sphere-forming abilities in culture condition are considered a hallmark of cancer stem-like cells, which represents tumor cell invasiveness and stem-like characteristics. We aimed to show that the sphere-forming subpopulation of human malignant melanoma cell line WM-266-4 acts differently to zebrafish embryo extracts compared with their bulk counterpart. Spheres were maintained in neural stem cell culture conditions. The embryos of zebrafish at specific developmental stages were collected and the extracts were purified under 100 kDa. Spheres were treated with embyo extracts and proliferation assay and immunocytochemistry were conducted. Spheroid cells expressed nestin and epidermal growth factor receptor (EGFR) but not melanoma antigen recognized by T-cells (MART)1, indicating their stem-l...

2009-01-01

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Suppressive effects of cadmium on neurons and affected proteins in cultured developing cortical cells

Zebrafish TRPA1 Channels are Required for Chemosensation but not for Thermosensation or Mechanosensory Hair Cell Function

The purpose of the present study was to examine the in vitro effects of low-dose cadmium (Cd) on developing cortical cells. The cortical cells removed from fetuses (embryonic day 15) were treated with 10 nM of Cd for 24 h. The effects of Cd on dendritic and synaptic development were immunocytochemically observed with anti-microtubule associated protein-2 (MAP2) and anti-synapsin I antibodies, respectively. Administration of Cd suppressed dendritic as well as synaptic development at 10 nM. By two-dimensional gel electrophoresis and liquid chromatography-tandem mass spectrometric (LC/MS/MS) analysis, we identified three proteins with different expression after Cd-treatment; dihydropyrimidinase-related protein 2 (DRP-2/CRMP-2), 14-3-3-epsillon and calmodulin (CaM). Though the number of identified proteins was small, these proteins are known to be involved in neuronal development. The ...

2008-11-20

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Transposable elements in fish functional genomics: technical challenges and perspectives

Transient receptor potential (TRP) ion channels have been implicated in detecting chemical, thermal and mechanical stimuli in organisms ranging from mammals to Caenorhabditis elegans....Full Text Available

2008-10-01

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The zebrafish heart regenerates after cryoinjury-induced myocardial infarction

The recent introduction of several transposable elements in zebrafish opens new frontiers for genetic manipulation in this important vertebrate model. This review discusses transposable elements as...Full Text Available

2007-01-01

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The rapid generation of chimerical genes expanding protein diversity in zebrafish

BackgroundIn humans, myocardial infarction is characterized by irreversible loss of heart tissue, which becomes replaced with a fibrous scar. By contrast, teleost fish and urodele...Full Text Available

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Shared versus specialized glycinergic spinal interneurons in axial motor circuits of larval zebrafish

BackgroundVariation of gene number among species indicates that there is a general process of new gene origination. One of the major mechanism providing raw materials for the origin...Full Text Available

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Sequence and expression of the zebrafish alpha-actinin gene family reveals conservation and diversification among vertebrates

The neuronal networks in spinal cord can produce a diverse array of motor behaviors. In aquatic vertebrates such as fishes and tadpoles, these include escape behaviors, swimming across a range...Full Text Available

2008-11-26

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PGE2-regulated wnt signaling and N-acetylcysteine are synergistically hepatoprotective in zebrafish acetaminophen injury

alpha-actinins are actin microfilament crosslinking proteins. Vertebrate actinins fall into two classes: the broadly-expressed actinins 1 and 4 (actn1 and actn4)...Full Text Available

2009-11-01

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Efficient discovery of ASCL1 regulatory sequences through transgene pooling

Acetaminophen (APAP) toxicity is the most common drug-induced cause of acute liver failure in the United States. The only available treatment, N-acetylcysteine (NAC), has a limited...Full Text Available

2010-10-05

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A genome-wide survey of Major Histocompatibility Complex (MHC) genes and their paralogues in zebrafish

Zebrafish transgenesis is a powerful and increasingly common strategy to assay vertebrate transcriptional regulatory control. Several challenges remain, however, to the broader application of...Full Text Available

2010-06-01

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The Future of Induced Pluripotent Stem Cells for Cardiac Therapy and Drug Development.

BackgroundThe genomic organisation of the Major Histocompatibility Complex (MHC) varies greatly between different vertebrates. In mammals, the classical MHC consists of a large number...Full Text Available

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The effects of short term and chronic exposure to tritiated drinking water on pre- and postnatal brain development

The field of stem cell research was revolutionized with the advent of induced pluripotent stem cells. By reprogramming somatic cells to pluripotent stem cells, most ethical concerns associated with the use of embryonic stem cells are overcome, such that many hopes from the stem cell field now seem a step closer to reality. Several methods and cell sources have been described to create induced pluripotent stem cells and we discuss their characteristics in terms of feasibility and efficiency. From these cells, cardiac progenitors and cardiomyocytes can be derived by several protocols and most recent advances as well as remaining limitations are being discussed. However in the short time period this technology has been around, evidence emerges that induced pluripotent stem cells may be more prone to genetic defects and maintain an epigenetic memory and thus may not be entirely the same as embryonic stem cells. Despite the lack of a complete ...

2011-09-15

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Transcription regulation of the vegf gene by the BMP/Smad pathway in the angioblast of zebrafish embryos

Ingestion of HTO during oocyte maturation and continued during pre-implantation time was found to depress decidual response. At birth these offspring also showed a decrease in brain cell number. When HTO was given during pregnancy only, the offspring at birth showed a similar deficit in brain cell number. Even so, we could not demonstrate a gross deficit in oocyte maturation when HTO was ingested during sexual maturity only; however, when further continued during pregnancy, the measured newborn parameters were most severely affected. In this group, cell-multiplication in the cerebrum was severely decreased, protein synthesis was decreased, and somatic growth was also highly significantly decreased. These experiments indicate that even a short-term exposure to HTO during early pregnancy (pre-implantation) alters normal development to such an extent that it is still observable at birth. During embryonic development, HTO ...

1980-11-26

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The CMV early enhancer/chicken beta actin (CAG) promoter can be used to drive transgene expression during the differentiation of murine embryonic stem cells into vascular progenitors.

Vascular endothelial growth factor (VEGF) is a mitogen that is critically involved in vasculogenesis, angiogenesis, and hematopoiesis. However, what and how transcription factors participate in the regulation of vegf gene expression are not fully understood. Here we report the cloning and sequencing of the zebrafish vegf promoter which revealed that the promoter contains a number of bone morphogenetic protein (BMP)-activated Smad binding elements (SBE), implicating Smad1 and Smad5 in the regulation of BMP-induced expression of vegf. Electrophoretic mobility shift assays of adding recombinant Smad proteins to the SBE-containing DNA oligonucleotides that represent portions of zebrafish vegf promoter resulted in mobility shift of the oligonucleotides. These changes demonstrate potential interactions between Smad1/5 and the vegf promoter. Reporter activity assays using the wild-type or SBE-deleted vegf promoters to drive the luciferase reporter ...

2005-04-01

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Isolation and differentiation of chondrocytic cells derived from human embryonic stem cells using dlk1/FA1 as a novel surface marker

Udgivelsesdato: 2008-null

2008-01-01

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Epithelial cells derived from human embryonic stem cells display p16INK4A senescence, hypermotility, and differentiation properties shared by many P63+ somatic cell types

Udgivelsesdato: 2009-Dec

2009-01-01

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Embryonic Retinal Cells and Support to Mature Retinal Neurons

Udgivelsesdato: 2009-Jun

2009-01-01

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Transcription Factor IIA t Is Associated with Undifferentiated Cells and Its Gene Expression Is Repressed in Primary Neurons at the Chromatin Level In Vivo

Purpose.There is a paucity of neuron replacement studies for retinal ganglion cells. Given the complex phenotype of these neurons, replacement of ganglion cells may be impossible....Full Text Available

2010-04-01

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British Library Electronic Table of Contents (United Kingdom)

The levels of General Transcription Factor (TF) IIA were examined during mammalian brain development and in rat embryo fibroblasts and transformed cell lines. The large TFIIA subunit paralogues ab and t are largely produced in unsynchronized cell lines, yet only TFIIA ab is observed in a number of differentiated tissue extracts. Steady-state protein levels of the TFIIA t, ab, and g subunits were significantly reduced when human embryonal (ec) and hepatic carcinoma cell lines were stimulated to differentiate with either all-trans-retinoic acid (ATRA) or sodium butyrate. ATRA-treated NT2-ec cells required replating to induce a neuronal phenotype and loss of detectable TFIIA t and g proteins. High levels of TFIIA t, ab, and g and Sp factors were identified in extracts from human fetal and rat...

2006-01-01

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Radiation induced micrencephaly in guinea pigs

Ectopic expression of Cux1 is associated with reduced p27 expression and increased apoptosis during late stage cyst progression upon inactivation of Pkd1 in collecting ducts

A brain weight deficit of about 70 mg was induced at doses of approximately 75-mGy and a deficit of 60 mg was induced at 100 mGy. This confirms the effects projected and observed by Wanner and Edwards. Although the data do not demonstrate a clear dose-response relationship between the 75-mGy and 100-mGy groups, the data are statistically consistent with a dose-response effect because of the overlapping confidence intervals. The lack of a statistically significant observation is most likely related to the small difference in doses and the limited numbers of animals examined. There are several factors that can influence the brain weight of guinea pig pups, such as caging and housing conditions, the sex of the animal, and litter size. These should be taken into account for accurate analysis. Dam weight did not appear to have a significant effect. The confirmation of a micrencephalic effect induced x rays at doses of 75-mGy during this late embryonic stage of ...

2006-04-20

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British Library Electronic Table of Contents (United Kingdom)

Abstract Polycystic kidney diseases (PKD) are inherited disorders characterized by fluid-filled cysts primarily in the kidneys. We previously reported differences between the expression of Cux1, p21, and p27 in the cpk and Pkd1 null mouse models of PKD. Embryonic lethality of Pkd1 null mice limits its study to early stages of kidney development. Therefore, we examined mice with a collecting duct specific deletion in the Pkd1 gene. Cux1 was ectopically expressed in the cyst lining epithelial cells of newborn, P7 and P15 Pkd1CD mice. Cux1 expression correlated with cell proliferation in early stages of cystogenesis, however, as the disease progressed, fewer cyst lining cells showed increased cell proliferation. Rather, Cux1 expression in late stage cystogenesis was associated with increased ...

2011-01-01

70

Astrocytes derived from trisomic human embryonic stem cells express markers of astrocytic cancer cells and premalignant stem-like progenitors

Activation of a multisensory, multifunctional nucleus in the zebrafish midbrain during diverse locomotor behaviors

BackgroundTrisomic variants of human embryonic stem cells (hESCs) arise spontaneously in culture. Although trisomic hESCs share many properties with diploid hESCs, they also exhibit...Full Text Available

71

British Library Electronic Table of Contents (United Kingdom)

Action potentials from the brain control the activity of spinal neural networks to produce, by as yet unknown mechanisms, a variety of motor behaviors. Particularly lacking are details on how identified descending neurons integrate diverse sensory inputs to generate specific locomotor patterns. We have examined the operations of the principal neurons in an intriguing midbrain nucleus, the nucleus of the medial longitudinal fasciculus (nMLF), in the larval zebrafish. The nMLF is the most rostral grouping of neurons that projects from the brain well into the spinal cord of teleost fishes, yet there is little direct physiological data available regarding its function. We report here that a distinct set of large, individually-identifiable neurons in nMLF (the MeL and MeM neurons) are activated...

2010-01-01

72

Development and thermal requirements of Orius insidiosus (Say) (Hemiptera: Anthocoridae); Desenvolvimento e exigencias termicas de Orius insidiosus (Say) (Hemiptera, Anthocoridae)

Disorders of brain development and phakomatosis

The temperature strongly influences the development time of insects and the understanding of this aspect for natural enemies is essential for its use as biocontrol agents and for mass rearing purpose. The objective of this work was evaluating the effect of different temperatures on the development time of Orius insidiosus (Say, 1832) as well as its thermal requirements. The trials were conducted in climatic chamber at 16, 19, 22, 25, 28 and 31 {+-} 1 deg C; RH 70 {+-} 10% and photo phase 12h. Eggs of Anagasta kuehniella (Zeller, 1879) were provided as food. The embryonic period was 14.0, 8.9, 6.6, 4.8, 3.9 and 3.3 days at 16, 19, 22, 25, 28 and 31 deg C, respectively. Nymphs of all instars (independent of originated sex) were affected by the temperature on their development time; there was a reduction of this period with the increase of the temperature. Males and females presented a ...

2005-10-15

73

Carcinogenicity of Black Rock Harbor sediment to the eastern oyster and trophic transfer of Black Rock Harbor carcinogens from the blue mussel to the winter flounder

Full text: Disorders of brain development and phakomatosis are resulting from disturbed embryonic-foetal development One third of all major embryological anomalies involve CNS, and over 2000 different anomalies have been described. Anomalies of the brain often cause foetal and neonatal death, and mental and physical retardation in pediatric group. The majority of disorders of brain development and phakomatosis are idiopathic, and most of them are not hereditary or familial. Ultrasonography plays the important role in screening foetal and neonatal brain, but after closure of fontanels it is difficult to find the acoustic window. CT has limited contrast resolution, and disadvantage exposing infant to ionizing radiation. It is helpful to demonstrate the presence of calcifications. MR imaging has proved to be a diagnostic tool of major importance in children with disorders of brain ...

74

Shielding of Sleeping Beauty DNA Transposon-delivered Transgene Cassettes by Heterologous Insulators in Early Embryonal Cells

The eastern oyster (Crassostrea virginica) developed neoplastic disorders when experimentally exposed both in the laboratory and field to chemically contaminated sediment from Black Rock Harbor (BRH), Bridgeport, Connecticut. Neoplasia was observed in oysters after 30 or 60 days of continuous exposure in a laboratory flow-through system to a 20 mg/L suspension of BRH sediment plus postexposure periods of 3, 30, or 60 days. Composite tumor incidence was 13.6% for both exposures. Tumor occurrence was highest in the renal excretory epithelium, followed in order by gill, gonad, gastrointestinal, heart, and embryonic neural tissue. Regression of experimental neoplasia was not observed when the stimulus was discontinued. In field experiments, gill neoplasms developed in oysters, deployed in cages for 30 days at BRH and 36 days at a BRH dredge material disposal area in Central Long Island Sound, and kidney and gastrointestinal ...

1991-01-01

75

SELF-RENEWAL AND DIFFERENTIATION OF MOUSE EMBRYONIC STEM CELLS AS MEASURED BY Oct4 GENE EXPRESSION: EFFECTS OF LIF, ...

The Sleeping Beauty (SB) transposon system represents an important alternative to viral integrating vector systems but may, as its viral counterparts, be subject to transcriptional silencing. To investigate...Full Text Available

2009-01-01

76

Rate of Dehydration and Cumulative Desiccation Stress Interacted to Modulate Desiccation Tolerance of Recalcitrant Cocoa and Ginkgo Embryonic Tissues1

... from Dr. Austin Smith of the Institute for Stem Cell Research, University of Edinburgh) was modified from the CGR8 ... to thank Dr. Austin Smith, the Institute for Stem Cell Research, University of Edinbu...

77

RNA recognition by the embryonic cell fate determinant and germline totipotency factor MEX-3

Rate of dehydration greatly affects desiccation tolerance of recalcitrant seeds. This effect is presumably related to two different stress vectors: direct mechanical or physical stress because of the...Full Text Available

2002-04-01

78

Progress with Nonhuman Primate Embryonic Stem Cells1

Totipotent stem cells have the potential to differentiate into every cell type. Renewal of totipotent stem cells in the germline and cellular differentiation during early embryogenesis rely upon posttranscriptional...Full Text Available

2009-12-01

79

Loss of Function of E-Cadherin in Embryonic Stem Cells and the Relevance to Models of Tumorigenesis

... based, disease treatment remains promising, the emphasis for stem cell research from the biomedical research community is clear, and ... diagnosis as a novel source of embryos for stem cell research. Repr...

80

Genome-Wide Analysis Reveals a Major Role in Cell Fate Maintenance and an Unexpected Role in Endoreduplication for the Drosophila FoxA Gene Fork Head

E-cadherin is the primary cell adhesion molecule within the epithelium, and loss of this protein is associated with a more aggressive tumour phenotype and poorer patient prognosis in many cancers. Loss...Full Text Available

2011-01-01

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81

Embryonic anti-aging niche

Transcription factors drive organogenesis, from the initiation of cell fate decisions to the maintenance and implementation of these decisions. The Drosophila embryonic salivary gland...Full Text Available

82

Diterpene Biosynthesis in Maize Seedlings in Response to Fungal Infection ¹

Although functional organ stem cells persist in the old, tissue damage invariably overwhelms tissue repair, ultimately causing the demise of an organism. The poor performance of stem cells in an aged...Full Text Available

83

CXCL12-Mediated Guidance of Migrating Embryonic Stem Cell-Derived Neural Progenitors Transplanted into the Hippocampus

A cell-free system which catalyzes the biosynthesis of terpene hydrocarbons when supplemented with mevalonate, Mn²⁺, and ATP was prepared from the scutellum-embryonic axis region of maize...Full Text Available

1979-09-01

84

CD133 Positive Embryonal Rhabdomyosarcoma Stem-Like Cell Population Is Enriched in Rhabdospheres

Stem cell therapies for neurodegenerative disorders require accurate delivery of the transplanted cells to the sites of damage. Numerous studies have established that fluid injections to the hippocampus...Full Text Available

85

Agonist-dependent up-regulation of thyrotrophin-releasing hormone receptor protein.

Cancer stem cells (CSCs) have been identified in a number of solid tumors, but not yet in rhabdomyosarcoma (RMS), the most frequently occurring soft tissue tumor in childhood. Hence, the aim of this...Full Text Available

86

A retinoid responsive cytokine gene, MK, is preferentially expressed in the proximal tubules of the kidney and human tumor cell lines.

To study the effect of agonist on the TRH (thyrotrophin-releasing hormone) receptor protein, an epitope-tagged receptor was stably expressed in HEK-293 cells (human embryonic kidney 293 cells) and receptor...Full Text Available

2004-06-15

87

A piggyBac transposon-based genome-wide library of insertionally mutated Blm-deficient murine ES cells

The aim of this study was to survey the expression of an embryonic cytokine gene, MK, in the normal organs and neoplastic tissues of adults. Northern analysis showed that MK mRNA was exclusively expressed...Full Text Available

1993-02-01

88

Harm to the cell and harm to the individual

Cultured mouse or human embryonic stem (ES) cells provide access to all of the genes required to elaborate the fundamental components and physiological systems of a mammalian cell. Chemical or insertional...Full Text Available

2009-04-01

89

Stem cells: Research tools and clinical treatments

Exposures from most natural and artificial sources, with the exception of those from medical radiology, are received at average dose rates of only a few microsieverts a day. Such risks as may be caused by these exposures are most unlikely to be determined with precision directly by epidemiological studies of populations exposed at these low rates. They may, however, be reliably inferred from the observed risks of exposure to rather larger doses delivered at higher dose rates in the light of the increasing knowledge of the phenomena involved in the initial cellular damage, the extent to which such damage is incorrectly repaired, and the processes which intervene between the genetic or other harm to cells and the likelihood of its final expression in inherited abnormality, in cancer development, or in defective foetal or embryonic growth. Current studies are of great importance, therefore, in examining the circumstances in which coding sections ...

1983-04-11

90

British Library Electronic Table of Contents (United Kingdom)

Abstract The term -stem cell- most commonly refers to embryonic stem cells, particularly in the lay media; however, it also describes other cell types. A stem cell represents a cell of multi-lineage potential with the ability for self-renewal. It is now clear that the plasticity and immortality of a given stem cell will depend on what type of stem cell it is, whether an embryonic stem cell, a fetal-placental stem cell or an adult stem cell. Stem cells offer great promise as cell-based therapies for the future. With evolving technology, much of the socio-political debate regarding stem cells can now be avoided.

2011-01-01

91

Functions of mammalian Cdc7 kinase in initiation/monitoring of DNA replication and development

HSP70, the earliest-induced gene in the zebrafish retina during optic nerve regeneration: Its role in cell survival

Cdc7 kinase plays an essential role in firing of replication origins by phosphorylating components of the replication complexes. Cdc7 kinase has also been implicated in S phase checkpoint signaling downstream of the ATR and Chk1 kinases. Inactivation of Cdc7 in yeast results in arrest of cell growth with 1C DNA content after completion of the ongoing DNA replication. In contrast, conditional inactivation of Cdc7 in undifferentiated mouse embryonic stem (ES) cells leads to growth arrest with rapid cessation of DNA synthesis, suggesting requirement of Cdc7 functions for continuation of ongoing DNA synthesis. Furthermore, loss of Cdc7 function induces recombinational repair (nuclear Rad51 foci) and G2/M checkpoint responses (inhibition of Cdc2 kinase). Eventually, p53 becomes highly activated and the cells undergo massive p53-dependent apoptosis. Thus, defective origin activation in mammalian cells can generate DNA replication checkpoint signals. Efficient removal of ...

2003-11-27

92

British Library Electronic Table of Contents (United Kingdom)

Fish retinal ganglion cells (RGCs) can survive and regrow their axons after optic nerve injury. Injured RGCs express anti-apoptotic proteins, such as Bcl-2, after nerve injury; however, upstream effectors of this anti-apoptotic protein are not yet fully understood. Heat shock proteins (HSPs) play a crucial role in cell survival against various stress conditions. In this study, we focused on HSP70 expression in the zebrafish retina after optic nerve injury. HSP70 mRNA and protein levels increased rapidly 2.3-fold in RGCs by 1-6 h after injury and returned to control levels by 1-3 days. HSP70 transcription is regulated by heat shock factor 1 (HSF1). HSF1 mRNA and phosphorylated-HSF1 protein rapidly increased by 2.2-fold in RGCs 0.5-6 h after injury. Intraocular injection of HSP inhibitor I s...

2011-01-01

93

The neuronal nicotinic acetylcholine receptor {alpha}7 subunit gene: Cloning, mapping, structure, and targeting in mouse

In vitro assessment of the agonist properties of the novel 5-HT_1_A receptor ligand, CUMI-101 (MMP), in rat brain tissue

The neuronal nicotinic acetylcholine receptor {alpha}7 subunit is a member of a family of ligand-gated ion channels, and is the only subunit know to bind {alpha}-bungarotoxin in mammalian brain. {alpha}-Bungarotoxin binding sites are known to be more abundant in the hippocampus of mouse strains that are particularly sensitive to nicotine-induced seizures. The {alpha}7 receptor is highly permeable to calcium, which could suggest a role in synaptic plasticity in the nervous system. Auditory gating deficiency, an abnormal response to a second auditory stimulus, is characteristic of schizophrenia. Mouse strains that exhibit a similar gating deficit have reduced hippocampal expression of the {alpha}7 subunit. We have cloned and sequenced the full length cDNA for the mouse {alpha}7 gene (Acra-7) and characterized its gene structure. The murine {alpha}7 shares amino acid identity of 99% and 93% with the rat and human {alpha}7 subunits, respectively. Using an interspecies backcross panel, the ...

1994-09-01

94

Deficiency of the housekeeping gene hypoxanthine-guanine phosphoribosyltransferase (HPRT) dysregulates neurogenesis.

Introduction: Development of agonist positron emission tomography (PET) radioligands for the 5-HT neurotransmitter system is an important target to enable the understanding of human 5-HT function in vivo. ["1"1C]CUMI-101, proposed as the first 5-HT_1_A receptor agonist PET ligand, has been reported to behave as a potent 5-HT_1_A agonist in a cellular system stably expressing human recombinant 5-HT_1_A receptors. In this study, we investigate the agonist properties of CUMI-101 in rat brain tissue. Methods: ["3"5S]-GTP#gamma#S binding studies were used to determine receptor function in HEK (human embryonic kidney) 293 cells transfected with human recombinant 5-HT_1_A receptors and in rat cortex and rat hippocampal tissue, following administration of CUMI-101 and standard 5-HT1A antagonists (5-HT, 5-CT and 8-OH-DPAT). Results: CUMI-101 behaved as an agonist at human recombinant 5-HT_1_A receptors (pEC_5_0 9.2). However, CUMI-101 did not show ...

2011-02-01

95

Functionally defined substates within the human embryonic stem cell compartment.

Neuronal transcription factors play vital roles in the specification and development of neurons, including dopaminergic (DA) neurons. Mutations in the gene encoding the purine biosynthetic enzyme hypoxanthine-guanine phosphoribosyltransferase (HPRT) cause the resulting intractable and largely untreatable neurological impairment of Lesch-Nyhan disease (LND). The disorder is associated with a defect in basal ganglia DA pathways. The mechanisms connecting the purine metabolic defect and the central nervous system (CNS) phenotype are poorly understood but have been presumed to reflect a developmental defect of DA neurons. We have examined the effect of HPRT deficiency on the differentiation of neurons in the well-established human (NT2) embryonic carcinoma neurogenesis model. We have used a retrovirus expressing a small hairpin RNA (shRNA) to knock down HPRT gene expression and have examined the expression of a number of transcription factors ...

2009-08-11

96

Bioethics and the Stem Cell Research Debate

Human embryonic stem (ES) cells can undergo spontaneously differentiation in standard culture conditions, demonstrating that the undifferentiated state is relatively unstable. The heterogeneous expression of SSEA3 observed within human ES colonies, provides a means to examine undifferentiated stem cell substates. Through functional testing of single cells we have shown that undifferentiated ES cells can be segregated into functionally discrete subpopulations on the basis of SSEA3 expression: SSEA3(High), SSEA(Low) and SSEA3(Negative). Human ES subpopulations were found to be interconvertible, but they possess distinct properties when challenged to differentiate along the neural lineage. These data suggest that ES cells with pluripotent/self-renewal capacities can exhibit different responses to induction of differentiation. PMID:21763622

2011-05-11

97

Establishment and Maintenance of Human Embryonic Stem Cell Lines on Human Feeder Cells Derived from Uterine Endometrium ...

Bioethics--the study of ethical issues in science and medicine--has grown to become a significant academic and service-oriented discipline with its own research centers, conferences, journals, and degree programs. As these issues have moved to the center of public debate, the law has assumed an increasingly important place in the discipline of bioethics. Today, embryonic stem cell research stands out as a critically important issue about which the U.S. has neither ethical consensus nor clear, comprehensive regulation. The ethical debate centers on the fact that stem cell research involves the destruction of very early human embryos. This article provides a brief scientific background followed by a discussion of key ethical and legal/regulatory issues that surround embryonic stem cell research.

2005-12-01

98

A System-Based Comparison of Gene Expression Reveals Alterations in Oxidative Stress, Disruption of Ubiquitin-Proteasome System and Altered Cell Cycle Regulation after Exposure to Cadmium and Methylmercury in Mouse Embryonic Fibroblast

... and pathogen transmission. Because the ultimate object of stem cell research is cell-based clinical therapy, hES cells should ... 4%) Supported by grants (SC12021 and SC11012) from Stem Cell Research...

99

ECRbase: Database of Evolutionary Conserved Regions, Promoters, and Transcription Factor Binding Sites in Vertebrate Genomes

Environmental and occupational exposures to heavy metals such as methylmercury (MeHg) and cadmium (Cd) pose significant health risks to humans, including neurotoxicity. The underlying mechanisms of...Full Text Available

2010-04-01

100

Transplacental movement of inorganic lead in early and late gestation in the mouse

Evolutionary conservation of DNA sequences provides a tool for the identification of functional elements in genomes. We have created a database of evolutionary conserved regions (ECRs) in vertebrate genomes entitled ECRbase that is constructed from a collection of pairwise vertebrate genome alignments produced by the ECR Browser database. ECRbase features a database of syntenic blocks that recapitulate the evolution of rearrangements in vertebrates and a collection of promoters in all vertebrate genomes presented in the database. The database also contains a collection of annotated transcription factor binding sites (TFBS) in all ECRs and promoter elements. ECRbase currently includes human, rhesus macaque, dog, opossum, rat, mouse, chicken, frog, zebrafish, and two pufferfish genomes. It is freely accessible at http://ECRbase.dcode.org.

2006-08-08

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101

Transplacental movement of inorganic lead in early and late gestation in the mouse

/sup 203/Pb(NO/sub 3/)/sub 2/ was administered i.v. to pregnant C57BL mice at different stages, from day 8 to day 18 of gestation. The whole animals or excised uteri were subjected to autoradiography or were autopsied for scintillation counting of excised organs. Lead appeared in embryonic and fetal tissues at all stages of gestation. Early (approx. day 8-11) lead was restricted mainly to the embryonic blood, suggesting that free lead was essentially not transferred to the embryo but may have been incorporated in the embryonic hemoglobin when the erythrocytes were formed in the yolk sac placenta (an extraembryonic membrane). From day 12 and later, an uptake was seen in the liver and the cartilaginous skeleton, and from day 14, a strong accumulation was found in calcified bone. This means that the overall fetal concentration increases successively with gestational age of the conceptus. The uptake in fetal liver may be ...

1983-10-01

102

cDNA cloning and sequence analysis of preproendothelin-1 (PPET-1) from salmon, Oncorhynchus keta.

"2"0"3Pb(NO_3)_2 was administered i.v. to pregnant C57BL mice at different stages, from day 8 to day 18 of gestation. The whole animals or excised uteri were subjected to autoradiography or were autopsied for scintillation counting of excised organs. Lead appeared in embryonic and fetal tissues at all stages of gestation. Early (approx. day 8-11) lead was restricted mainly to the embryonic blood, suggesting that free lead was essentially not transferred to the embryo but may have been incorporated in the embryonic hemoglobin when the erythrocytes were formed in the yolk sac placenta (an extraembryonic membrane). From day 12 and later, an uptake was seen in the liver and the cartilaginous skeleton, and from day 14, a strong accumulation was found in calcified bone. This means that the overall fetal concentration increases successively with gestational age of the conceptus. The uptake in fetal liver may be related to the ...

103

Transient suppression of MLH1 allows effective single-nucleotide substitution by single-stranded DNA oligonucleotides

The presence of endothelin (ET)-like immunoreactivity and the cardiovascular effects of mammalian ET-1 in fish have been reported. To identify ET-related peptides in fish, we screened the cDNA library of the salmon (Oncorhynchus keta) stomach by means of rapid amplification of cDNA ends, and we cloned cDNAs encoding an ET-related peptide. The salmon ET-related sequence of 21 amino acids is identical to the trout ET-1 peptide recently purified from kidney specimens of Oncorhynchus mykiss. The deduced amino acid sequence of salmon pre-proET-1 (PPET-1) comprises 244 amino acids, including a putative signal sequence and mature ET-1, as well as big ET-1 and ET-1-like sequences. This precursor, the first reported PPET-1 sequence for Salmoniformes, Teleostei, has low homology with the sequences of human, mouse, frog (Xenopus laevis), and zebrafish (Danio rerio) PPET-1 (26%, 29%, 24%, and 39%, respectively). PMID:16740985

2006-06-01

104

British Library Electronic Table of Contents (United Kingdom)

Short synthetic single-stranded oligodeoxyribonucleotides (ssODNs) can be used to introduce subtle modifications into the genome of mouse embryonic stem cells (ESCs). We have previously shown that effective application of ssODN-mediated gene targeting in ESC requires (transient) suppression of DNA mismatch repair (MMR). However, whereas transient down-regulation of the mismatch recognition protein MSH2 allowed substitution of 3 or 4 nucleotides, 1 or 2 nucleotide substitutions were still suppressed. We now demonstrate that single- or dinucleotide substitution can effectively be achieved by transient down-regulation of the downstream MMR protein MLH1. By exploiting highly specific real-time PCR, we demonstrate the feasibility of substituting a single basepair in a non-selectable gene. Howev...

2011-01-01

105

Pigpen, a nuclear coiled body component protein, is involved in angiogenesis

British Library Electronic Table of Contents (United Kingdom)

We previously reported that puromycin-insensitive leucyl-specific aminopeptidase (PILSAP) is required for vascular endothelial growth factor (VEGF)- and basic fibroblast growth factor (bFGF)-induced angiogenesis and for endothelial differentiation from embryonic stem (ES) cells via the aminopeptidase activity of PILSAP. In this study, we searched for molecules that function during angiogenesis with PILSAP. We performed proteome analysis of nuclear extracts from embryoid bodies (EBs) made from ES cells transfected with mutant PILSAP lacking aminopeptidase activity and mock EBs. We identified pigpen, a 67-kDa nuclear coiled body component protein. Immunoprecipitation and western blotting demonstrated the binding of PILSAP and pigpen in endothelial cells (ECs), and this interaction was enhanc...

2010-01-01

106

Mary Lyon and the hypothesis of random X chromosome inactivation

British Library Electronic Table of Contents (United Kingdom)

The 50th anniversary of Mary Lyon?s 1961 Nature paper, proposing random inactivation in early embryonic life of one of the two X chromosomes in the cells of mammalian females, provides an opportunity to remember and celebrate the work of those involved. While the hypothesis was initially put forward by Lyon based on findings in the mouse, it was founded on earlier studies, notably the work of Susumu Ohno; it was also suggested independently by Beutler and colleagues using experimental evidence from a human X-linked disorder, glucose-6-phosphate dehydrogenase deficiency, and has proved to be of as great importance for human and medical genetics as it has for general mammalian genetics. Alongside the hypothesis itself, previous cytological studies of mouse and human chromosomes, and the obse...

2011-01-01

107

Identification of a functional nuclear export signal in the green fluorescent protein asFP499

Variations in humanized and defined culture conditions supporting derivation of new human embryonic stem cell lines

The green fluorescent protein (GFP) asFP499 from Anemonia sulcata is a distant homologue of the GFP from Aequorea victoria. We cloned the asFP499 gene into a mammalian expression vector and showed that this protein was expressed in the human lymphoblast cell line Ramos RA1 and in the embryonic kidney 293T cell line (HEK 293T). In HEK 293T cells, asFP499 was localized mainly in the cytoplasm, suggesting that the protein was excluded from the nucleus. We identified _1_9_4LRMEKLNI_2_0_1 as a candidate nuclear export signal in asFP499 and mutated the isoleucine at position 201 to an alanine. Unlike the wildtype form, the mutant protein was distributed throughout the cytoplasm and nucleus. This is First report of a GFP that contains a functional NES.

2006-04-21

108

Cytogenetic effects of protracted gamma exposures from conception of male mice

The evolution of "humanized" (i.e., free of animal sourced reagents) and ultimately chemically defined culture systems for human embryo stem cell (hESC) isolation and culture is of importance to improving their efficacy and safety in research and therapeutic applications. This can be achieved by integration of a multitude of individual approaches to replace or eliminate specific animal sourced reagents into a single comprehensive protocol. In the present study our objective was to integrate strategies obviating reliance on some of the most poorly defined and path-critical factors associated with hESC derivation, namely the use of animal immune compliment to isolate embryo inner cell mass, and animal sourced serum products and feeder cells to sustain hESC growth and attachment. As a result we report the derivation of six new hESC lines isolated by outgrowth from whole blastocysts on an extracellular matrix substrate of purified human laminin (Ln) with transitional reliance on ...

2006-01-01

109

Computational identification of developmental enhancers:conservation and function of transcription factor binding-site clustersin drosophila melanogaster and drosophila psedoobscura

In order to gain an overall picture of the genetic effects of an increased level of background radiation it is necessary to study the results of protracted exposures to embryonic and immature germ-cell stages as well as to stages found in the mature organism. For this purpose, litters produced by female mice, kept in a 10 or 20 rad/day /sup 60/Co ..gamma..-irradiation field, were kept in the same fields from conception until about 60 days later, having absorbed doses of 526 and 1078 rad respectively. Tests on exposed female offspring showed them to be sterile. Eight weeks after removal from the gamma field, mean testis masses of males in the 20 rad/day series were only half normal but those receiving 10 rad/day were little affected. Frequencies of translocations in spermatocytes at diakinesis/metaphase I were only slightly increased in the exposed series, differences not being significant. Estimated rates of translocation induction were around 5 x 10sup(-6) per ...

1982-01-01

110

Study of the reproductive efficiency of dual purpose cattle in Panama through the use of radioimmunoassay techniques

Background The identification of sequences that control transcription in metazoans is a major goal of genome analysis. In a previous study, we demonstrated that searching for clusters of predicted transcription factor binding sites could discover active regulatory sequences, and identified 37 regions of the Drosophila melanogaster genome with high densities of predicted binding sites for five transcription factors involved in anterior-posterior embryonic patterning. Nine of these clusters overlapped known enhancers. Here, we report the results of in vivo functional analysis of 27 remaining clusters. Results We generated transgenic flies carrying each cluster attached to a basal promoter and reporter gene, and assayed embryos for reporter gene expression. Six clusters are enhancers of adjacent genes: giant, fushi tarazu, odd-skipped, nubbin, squeeze and pdm2; three drive expression in patterns unrelated to those of neighboring genes; the remaining 18 do not appear ...

2004-08-06

111

Rhipicephalus sanguineus: vector of a new spotted fever group rickettsia in the United States.

Reproductive parameters were monitored in 50 post-partum Bos indicus x Bos taurus animals located on four farms in two ecological zones of Panama. Progesterone (P_4) concentrations were measured in four of these animals twice a week and their reproductive organs palpated per rectum once a week until 60 days post-artificial-insemination or post-natural-service. The other 46 cows were palpated for early pregnancy between days 45 and 60 post-service. The mean P_4 concentration in cows with palpable corpora lutea (CL) was 10.3#+-#4.0 nmol/L; when no Cl were detected, the mean P_4 level was 2.2#+-#1.6 nmol/L. Of the 46 animals palpated for early pregnancy, 36 (70%) were found to be pregnant, one (2%) exhibited early embryonic death and one (2%) aborted; the other eight cows (17%) were anoestrous. The mean P_4 concentration in pregnant cows was 11.9#+-#4.0 nmol/L and the calving to conception interval was 148 days. (author). 13 refs, 7 figs, 4 tabs.

112

Replication-defective vectors of reticuloendotheliosis virus transduce exogenous genes into somatic stem cells of the unincubated chicken embryo

A rickettsia related to but distinct from the spotted fever agent, Rickettsia rickettsii, has been detected in 167 (18.9%) of 884 Rhipicephalus sanguineus taken off dogs in central and northern Mississippi. The organisms could readily be isolated in male meadow voles (Microtus pennsylvanicus), where it produced massive infections in the tissues of tunica vaginalis. It was practically nonpathogenic for male guinea pigs, although inoculation of these animals with infected tunica vaginalis of voles afforded in 30 of 38 instances solid immunity to challenge with virulent R. rickettsii. The Rhipicephalus rickettsia grew well in monolayers of chicken embryo fibroblast, Vero, mouse L, and HeLa cells. Cytopathogenic effects were minimal unless large concentrations of rickettsiae were used as inocula. It also could be established in embryonated hen eggs but only after injection of massive doses of L cell-propagated organisms. Serological tests (complement fixation, ...

1975-07-01

113

Radiotherapy for ocular lesions by electron beam therapy

Replication-defective vectors derived from reticuloendotheliosis virus were used to transduce exogenous genes into early somatic stem cells of the chicken embryo. One of these vectors transduced and expressed the chicken growth hormone coding sequence. The helper cell line, C3, was used to generate stocks of vector containing about 10/sup 4/ transducing units per ml. Injection of 5- to 20-..mu..l volumes of vector directly beneath the blastoderm of unincubated chicken embryos led to infection of somatic stem cells. Infected embryos and adults contained unrearranged integrated proviral DNAs. Embryos expressed the transduced chicken growth hormone gene and contained high levels of serum growth hormone. Blood, brain, muscle, testis, and semen contained from individuals injected as embryos contained vector DNA. Replication-defective vectors of the reticuloendotheliosis virus transduced exogenous genes into chicken embryonic stem cells in vivo.

1989-06-01

114

Effect of chronic fractionated low-dose gamma irradiation on division potential of human embryonic cells in vitro

Radiotherapy can be very significant as the treatment for ocular lesions, eyes need to be preserved as properly as possible on their functions and cosmetics. The application of conventional X ray therapy has been gradually abandoned as conventional X ray therapy ceased to be accepted as the general treatment for malignant tumors. Consequently the necessity of electron beam therapy has been rising even as the substituted method for conventional X ray therapy. The department of radiology of Gunma University was obliged to establish a new therapy for ocular lesions, and has been trying electron beam therapy since 1973. It is concluded that electron beam therapy is not at all inferior to conventional X ray therapy as reported above. Basic therapeutic methods for ocular lesions are the following: 1) For epidermoid carcinoma, 600 rads at a time, 3600 - 4200 rads in total is applied by 8 MeV electron twice a week method. 2) For malignant melanoma, 1000 rads at a time, 4000 - 5000 rads in ...

1981-11-01

115

Detection of constitutive heterodimerization of the integrin Mac-1 subunits by fluorescence resonance energy transfer in living cells

We investigated the in vitro phenotypic transformation of human embryo (HE) cells that were repeatedly irradiated (7.5 cGy once a week) throughout their life-span. Irradiation was repeated until the cells had accumulated 195 cGy (equivalent to the 26th passage). Samples of cells were assayed for survival by colony formation, as well as for mutation at the hypoxanthine guanine phosphoribosyl transferase (HGPRT) locus and for transformation by focus formation. The life-span (mean number of population doublings) of multiply irradiated cells with a total dose of 97.5 cGy was slightly but significantly prolonged over that of controls. After HE cells had accumulated 195 cGy, the maximum number of divisions increased to 130-160% of the number in non-irradiated control cells. Transformed foci were not observed until cells had accumulated 97.5 cGy, and then increased with the increasing accumulation of radiation. However, no cells showed immortality or expressed a malignant phenotype in vitro. ...

1991-12-01

116

Macrophage differentiation antigen associated with complement three receptor function (Mac-1) belongs to #beta#_2 subfamily of integrins that mediate important cell-cell and cell-extracellular matrix interactions. Biochemical studies have indicated that Mac-1 is a constitutive heterodimer in vitro. Here, we detected the heterodimerization of Mac-1 subunits in living cells by means of two fluorescence resonance energy transfer (FRET) techniques (fluorescence microscopy and fluorescence spectroscopy) and our results demonstrated that there is constitutive heterodimerization of the Mac-1 subunits and this constitutive heterodimerization of the Mac-1 subunits is cell-type independent. Through FRET imaging, we found that heterodimers of Mac-1 mainly localized in plasma membrane, perinuclear, and Golgi area in living cells. Furthermore, through analysis of the estimated physical distances between cyan fluorescent protein (CFP) and yellow fluorescent protein (YFP) fused to Mac-1 subunits, we ...

2006-08-04

117

SC Development Programme

SC Development Programme

1967-01-01

118

Telomerase-immortalized non-malignant human prostate epithelial cells retain the properties of multipotent stem cells

The IRG protein Irgm3 preserves cell survival during coxsackievirus B3 (CVB3) infection. However, the molecular mechanisms are not clear. Here, we examined the effect of Irgm3 expression on ER stress triggered by pharmacological agents or CVB3 infection. In Tet-On/Irgm3 HeLa cells, Irgm3 expression suppressed either chemical- or CVB3-induced upregulation of glucose-regulated protein78. Further, Irgm3 strongly inhibited the activation of both the PERK and ATF6 pathways of ER stress responses, which further led to the diminished phosphorylation of eIF2?, reduced cleavage/activation of transcription factor SREBP1 and attenuated induction of proapoptotic genes CHOP and GADD34. These data were further supported by experiments using Irgm3 knockout mouse embryonic fibroblasts, in which the ER stress induced by CVB3 was not relieved due to the lack of Irgm3 expression. In addition, the tunicamycin-triggered ER stress promoted the subsequent CVB3 infection. The effect of ...

2011-10-10

119

Regulation of sulfated glycosaminoglycan production by prostaglandin E2 in cultured lung fibroblasts

Understanding prostate stem cells may provide insight into the origin of prostate cancer. Primary cells have been cultured from human prostate tissue but they usually survive only 15-20 population doublings before undergoing senescence. We report here that RC-170N/h/clone 7 cells, a clonal cell line from hTERT-immortalized primary non-malignant tissue-derived human prostate epithelial cell line (RC170N/h), retain multipotent stem cell properties. The RC-170N/h/clone 7 cells expressed a human embryonic stem cell marker, Oct-4, and potential prostate epithelial stem cell markers, CD133, integrin #alpha#2#beta#1"h"i and CD44. The RC-170N/h/clone 7 cells proliferated in KGM and Dulbecco's Modified Eagle Medium with 10% fetal bovine serum and 5 #mu#g/ml insulin (DMEM + 10% FBS + Ins.) medium, and differentiated into epithelial stem cells that expressed epithelial cell markers, including CK5/14, CD44, p63 and cytokeratin 18 (CK18); as well as the mesenchymal cell ...

2008-01-01

120

Neurite outgrowth effect of 4-O-methylhonokiol by induction of neurotrophic factors through ERK activation.

Prostaglandin E2 (PGE2) has been shown to increase the synthesis of hyaluronic acid in cultured fibroblasts by increasing the activity of hyaluronate synthetase, a group of plasma membrane-bound synthetic enzymes. We examined whether PGE2 also increased the activity of those enzyme systems involved in the synthesis of sulfated glycosaminoglycan in the human embryonic lung fibroblast. Exposure of cells to PGE2 resulted in dose-dependent increases in glucosamine incorporation into all sulfated glycosaminoglycan subtypes. PGE2 at 10(-7) mol/L increased total glycosaminoglycan per dish to 21.6 +/- 3.1 micrograms versus 12.0 +/- 2.5 micrograms in control untreated cultures. Stimulation of endogenous PGE2 production by bradykinin had a similar effect on glycosaminoglycan synthesis. To examine whether PGE2 affected sulfated glycosaminoglycan protein core production, cells were labeled with tritiated glucosamine in the presence of cycloheximide. Under these conditions, ...

1989-08-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

121

Molecular cloning of chicken metallothionein. Deduction of the complete amino acid sequence and analysis of expression using cloned cDNA

Compounds isolated from Magnolia officinalis such as magnolol, honokiol and obovatol exhibit several pharmacological effects on CNS including depressant, anxiolytic and anticonvulsant effects, as well as neuroprotective effects against chemical and heat damages. Recently, honokiol was found to have a neurotrophic effect in fetal rat cortical neurons. In the present study, we show that 4-O-methylhonokiol, a novel compound from Magnolia officinalis, promotes neurite outgrowth in a concentration- dependent manner in rat embryonic neuronal cells. In parallel with the neurite outgrowth activity, the expression of neurite outgrowth marker proteins is also increased by treatment with 4-O-methylhonokiol. We also found that 4-O-methylhonokiol promotes the release of NGF and BDNF into cell culture medium. In addition, lower concentration of 4-O-methylhonokiol (1 and 2 lM) further enhanced neurite outgrowth and expression of neurite outgrowth marker proteins in the presence ...

2009-12-01

122

Microfabricated polyester conical microwells for cell culture applications.

A cDNA library was constructed using RNA isolated from the livers of chickens which had been treated with zinc. This library was screened with a RNA probe complementary to mouse metallothionein-I (MT), and eight chicken MT cDNA clones were obtained. All of the cDNA clones contained nucleotide sequences homologous to regions of the longest (375 bp) cDNA clone. The latter contained an open reading frame of 189 bp, and the deduced amino acid sequence indicates a protein of 63 amino acids of which 20 are cysteine residues. Amino acid composition and partial amino acid sequence analyses of purified chicken MT protein agreed with the amino acid composition and sequence deduced from the cloned cDNA. Amino acid sequence comparison establish that chicken MT shares extensive homology with mammalian MTs. Southern blot analysis of chicken DNA indicates that the chicken MT gene is not a part of a large family of related sequences, but rather is likely to be a unique gene sequence. In the chicken ...

1988-01-25

123

In vivo footprinting of the human [alpha]-globin locus upstream regulatory element by guanine and adenine ligation-mediated polymerase chain reaction

Over the past few years there has been a great deal of interest in reducing experimental systems to a lab-on-a-chip scale. There has been particular interest in conducting high-throughput screening studies using microscale devices, for example in stem cell research. Microwells have emerged as the structure of choice for such tests. Most manufacturing approaches for microwell fabrication are based on photolithography, soft lithography, and etching. However, some of these approaches require extensive equipment, lengthy fabrication process, and modifications to the existing microwell patterns are costly. Here we show a convenient, fast, and low-cost method for fabricating microwells for cell culture applications by laser ablation of a polyester film coated with silicone glue. Microwell diameter was controlled by adjusting the laser power and speed, and the well depth by stacking several layers of film. By using this setup, a device containing hundreds of microwells can be fabricated in a ...

2011-05-26

124

Software Development Tools Service

A major regulatory element required for expression of the human [alpha]-globin genes is located 40 kb upstream of the embryonic [zeta]-globin gene. To understand how this and other locus control region (LCR) elements contribute to high-level expression in erythroid cells, we have performed high-resolution, in vivo dimethyl sulfate footprinting. In addition, we have modified the dimethyl sulfate-based ligation-mediated polymerase chain reaction in vivo footprinting procedure to permit the assessment of interactions at guanine and adenine residues, rather than guanines alone. In vivo footprinting of the human [alpha]-LCR element carried on chromosome 16 in a mouse erythroleukemia cell environment revealed protein occupancy at GATA-1, AP-1/NF-E2, and CACC/GGTGG motifs, specific differences compared with in vitro protein binding, and distinct changes in one region upon dimethyl sulfoxide-induced cellular maturation. No protein contacts were detected in nonexpressing ...

1992-05-01

125

CERN Multimedia

Software Development Tools Service

1999-01-01

126

Software Development Tools Service

CERN Multimedia

Software Development Tools Service

1998-01-01

127

Software Development Tools Service

CERN Multimedia

Software Development Tools Service

1997-01-01

128

Influenza Vaccines

Cryo-Optical Test Bed Development

Development of the Culture Influenza Vaccine

129

Indian Academy of Sciences (India)

Jan 22, 2004 ... Training and Professional Development Leadership Development Program. GSFC Leadership Development Program Positions. Cryo-Optical ...

130

Bioline International

- technology moving forward with new developments ...

131

Altering Sexual Development in Arabidopsis

Technology and Policy for Sustainable Development

Full Text Available

1998-06-01

132

Teacher Professional Continuum

The development of short-sea shipping will be fostered by the deployment of tracking and tracing systems,

133

Organizational structure and technology transfer

... efforts in developing and testing prototype materials or tools and Full Development Projects to ...

134

Magnetic forming coil design and development summary report

... administrative procedures developing countries economic development nuclear

1982-11-01

135

Estimating The Cost Of Developing Software

Magnetic forming coil design and development

1964-01-01

136

CZT Detector and HXI Development at CASS/UCSD

Software Cost Estimation Model program, SOFTCOST, developed to provide consistent automated

1991-01-01

137

Energy research and development. Ninety-Third Congress, First Session, December 1, 1973

CZT Detector and HXI Development at CASS/UCSD

2006-01-01

138

Instructional Materials Development Program

The Committee on Interior and Insular Affairs issued the report on a bill to establish a national program for research, development, and demonstration in fuels and energy and for the coordination and financial supplementation of Federal energy research and development; to establish development corporations to demonstrate technologies for shale oil development, advanced power cycle development, geothermal steam development, and coal liquefaction and gasification development; to authorize and direct the Secretary of the Interior to make mineral resources of the public lands available for the development conporations. Comments from governmental agencies on the bill are published. (MCW)

1973-01-01

139

Course and Curriculum Development Program, Evaluation Report

... Materials Development Program TECHNOLOGY EDUCATION INSTRUCTIONAL MATERIALS Elementary - High School ... of technology education materials through its Instructional Materials Development (IMD) program. The ...

140

The development of contemporary chiropractic education in Denmark: an exploratory study

... grants to adopt or adapt courses and materials developed by CCD projects at other institutions, and ... to adopt or adapt CCD-developed courses and materials. -iv- Accomplishments The CCD program has ...

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

141

Surface Decontamination by Solution

Udgivelsesdato: 2008-Oct

2008-01-01

142

Development of Technology for Metal Surface Decontamination in Aqueous Solutions

143

Safe climate

Review of the appropriateness of international assessment tools for a developing country

and develop markets for soy alternatives, such as lupins.14

144

CSIR Research Space (South Africa)

Full Text Available

145

Rap Signaling in Normal Lymphocyte Development and Leukemia Genesis

Molecular Genetics of Emericella nidulans Sexual Development

Full Text Available

2009-04-01

146

Lessons from Developing an Annotated Corpus of Patient Histories

Full Text Available

2009-09-01

147

Frequency Controlled Electric Drives

Full Text Available

2008-06-01

148

Development of the National Ecological Observatory Network (NEON)

Development of Frequency Controlled Electric Drives

149

Development of sup 203 Pb as a new label for monoclonal antibodies

Full Text Available

2007-02-01

150

Development of a Cost Effective Radio Communication System for UAS

Brief item.

1989-01-01

151

Development of Storage Management System for Small Dams

Full Text Available

2008-06-01

152

Development of Ceramic Body using Waste Celadon

Full Text Available

2005-05-01

153

Developing a national patient safety education framework for Australia.

Full Text Available

2009-11-01

154

Biological Surface-Active Substance

PMID:17142595

2006-12-01

155

Probabilistic Simulation for Nanocomposite Characterization Developed and Included in the Computer Code ICAN/JAVA

Development of biological preparation with surfactant activity

156

Hydrothermal industrialization electric-power systems development. Final report

A unique mechanistic method has been developed at the NASA Glenn Research Center to

2008-01-01

157

Electron-induced luminescence and x-ray spectrometer development: progress report

The nature of hydrothermal resources, their associated temperatures, geographic locations, and developable capacity are described. The parties involved in development, required activities and phases of development, regulatory and permitting requirements, environmental considerations, and time required to complete development activities ae examined in detail. These activities are put in proper perspective by detailing development costs. A profile of the geothermal industry is presented by detailing the participants and their operating characteristics. The current development status of geothermal energy in the US is detailed. The work on market penetration is summarized briefly. Detailed development information is presented for 56 high temperature sites. (MHR)

1982-03-01

158

Development of a Colony of Germfree Hamsters as a ...

The progress in the development of a surface analysis tool based on the excitation of characteristic

2003-01-01

159

Development of QTL Mapping Populations

... Accession Number : ADA021166. Title : Development of a Colony of Germfree Hamsters as a Biomedical Resource. Descriptive Note : Final rept. ...

1976-01-07

160

DEVELOPMENT OF A MANUFACTURING PROCESS AND ...

The objective of this animation is to develop a QTL mapping population for locating and characterizing the genes responsible for resistance to tan spot disease of wheat.

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

161

Development Application - Terra Nova Development - Supplement B to the Application

... This work was based upon previously successful development of combustible cartridge cases, at Illinois Institute of Technology Research Institute ...

1968-05-01

162

Coal development potential in Pakistan

Supplement B to the Terra Nova Development Application provides a description of the floating production storage and offloading (FPSO) vessel system selected for the development, a summary of the reasons for selecting the system, and the impact of this selection on the Development Plan, the Benefits Plan, the Environmental Impact Statement and the Socio-Economic Impact Statement. There is also a description of the contractor alliance approach to be used in the Terra Nova Development. Refs., tabs., figs.

1997-02-01

163

Practical MRI atlas of neonatal brain development

A total of 48 papers were presented, and covered the following topics: the current situation in Pakistan with respect to development and utilization of coal resources; the policies that have been responsible for the development and utilization of coal resources in Pakistan; coal development and utilization in other developing nations e.g. Indonesia, Greece, Philippines, China, Thailand and Haiti; and technological developments in coal exploration; extraction, handling, transport and utilization which could accelerate future development of Pakistan's coal resources. Specific subjects covered include the use of coal in the cement industry of Pakistan; the production of briquettes for domestic use, development and training of personnel for the coal industry; and sources of finance for coal development projects. ...

1986-01-01

164

Water Deficit and Spatial Pattern of Leaf Development. Variability in Responses Can Be Simulated Using a Simple Model of Leaf Development1

This book is an anatomical reference for cranial magnetic resonance imaging (MRI) studies in neonates and infants. It contains 122 clear, sharp MRI scans and drawings showing changes in the normal appearance of the brain and skull during development. Sections of the atlas depict the major processes of maturation: brain myelination, development of the corpus callosum, development of the cranial bone marrow, and iron deposition in the brain. High-quality scans illustrate how these changes appear on magnetic resonance images during various stages of development.

165

Using the Java language to develop computer based patient records for use on the Internet.

We analyzed the effect of short-term water deficits at different periods of sunflower (Helianthus annuus L.) leaf development on the spatial and temporal patterns of tissue expansion...Full Text Available

1999-02-01

166

Sex and Hormonal Variations in the Development of At-level Allodynia In a Rat Chronic Spinal Cord Injury Model

The development of the Java Programming Language by Sun Microsystems has provided a new tool for the development of Internet based applications. Our preliminary work has shown how Java can be used to...Full Text Available

1996-01-01

167

Sandia microelectronics development

The development of central neuropathic pain varies among patients with spinal cord injury (SCI). The factors contributing to the development and perpetuation of segmental pain (at-level allodynia)...Full Text Available

2010-06-25

168

Safety culture development at Daya Bay NPP

An overview of the operations of Sandia`s Microelectronics Development Lab (MDL) is to develop radiation hardened IC, but techniques used for IC processing have been applied to a variety of related technologies such as micromechanics, smart sensors, and packaging.

1997-02-01

169

Renewable energy and the ODA energy efficient strategy

From view on Organization Behavior theory, the concept, development and affecting factors of safety culture are introduced. The focuses are on the establishment, development and management practice for safety culture at Daya Bay NPP. A strong safety culture, also demonstrated, has contributed greatly to improving performance at Daya Bay

2001-12-01

170

Recent Developments in Coal Liquefaction at the Wilsonville Advanced Coal Liquefaction Research and Development Facility.

The energy strategy of the UK Overseas Development Administration is outlined with specific emphasis on energy efficiency and renewable energies. Based on 29 case studies concerning projects and programmes in both developed and developing countries, critical success factors for renewable energy projects are identified. UK)

1995-12-31

171

Effect of Surgical Alteration of the Rat Gastrointestinal Tract On the Growth and Development of Hymenolepis Diminuta

The results of the two most recently completed runs at the Wilsonville Advanced Coal Liquefaction Research and Development Facility are presented. In Run 255, initial screening of operating conditions for the liquefaction of a Texas lignite was completed....

1991-01-01

172

The ''Complex Reality'' of Research Capacity Development in Mathematics Education in Southern African Development Community Countries

... Gastrointestinal Tract On the Growth and Development of Hymenolepis DiminutaKerry L. Dwinell, Paul Bass, Gordon L. Telford, ... central (CNS) nervous systems in the development of Hymenolepis diminuta usi...

173

Traumatic retinal detachment.

This paper explores how an aid-funded Ph.D.-programme in mathematics education instituted in some Southern African Development Community countries measures up to issues related to research capacity development projects. The research capacity development programme is described and reflected against mutual benefit, relevance, sustainability and prioritization of the location of project funding expenditure--some of the constructs in the discourse on research capacity development initiatives. It is found that the benefits of the programme are indeed mutual; the outcomes regarding relevance and sustainability are more uncertain and the location of expenditure of the funding is not overtly in favour of the donor country.

2005-11-01

174

The mammalian oocyte orchestrates the rate of ovarian follicular development

Seventy-seven patients developed retinal breaks following an episode of ocular contusion, and 65 (84.4%) of these developed rhegmatogenous retinal detachment. Surgical treatment successfully restored...Full Text Available

1991-01-01

175

The Development of a Dental Diagnostic Terminology

The development of both the mammalian oocyte and the somatic cell compartments of the ovarian follicle is highly coordinated; this coordination ensures that the ovulated oocyte is ready to undergo fertilization...Full Text Available

2002-03-05

176

Symbiotic regulation of plant growth, development and reproduction

There is no commonly accepted standardized terminology for oral diagnoses. The purpose of this article is to report the development of a standardized dental diagnostic terminology by a work...Full Text Available

2011-01-01

177

Strategic Communication: A Department of Defense Approach

The growth and development of rice (Oryzae sativa) seedlings was shown to be regulated epigenetically by a fungal endophyte. In contrast to un-inoculated (nonsymbiotic) plants, endophyte...Full Text Available

2009-03-01

178

R/V Laurence M. Gould LMG0303 - Development of a luminescence - NASA

... development of SC policy within DOD, because it describes the necessary link between DOD ... strategy convolutes USG efforts to develop SC policy. ...

2007-03-28

179

Probiotic Bacteria as Biological Control Agents in Aquaculture

R/V Laurence M. Gould LMG0303 - Development of a luminescence dating capability for Antarctic glaciomarine sediments: Tests of signal zeroing at the ...

180

Meeting the resistance problem

There is an urgent need in aquaculture to develop microbial control strategies, since disease outbreaks are recognized as important constraints to aquaculture production and trade and since the development...Full Text Available

2000-12-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

181

In Defense of Change Processes

Because resistance to new insecticides may develop rapidly and cross resistance is often encountered, even between insecticides of different classes, there is a continual demand for the development...Full Text Available

1963-01-01

182

Hypothyroidism Enhances Tumor Invasiveness and Metastasis Development

Nativist and constructivist approaches to the study of development share a common emphasis on characterizing beginning and end states in development. This focus has highlighted the question...Full Text Available

2008-01-01

183

High-Temperature Solar Cell Development - GLTRS - NASA

BackgroundWhereas there is increasing evidence that loss of expression and/or function of the thyroid hormone receptors (TRs) could result in a selective advantage for tumor development,...Full Text Available

184

Environmental estrogens alter early development in Xenopus laevis.

High-Temperature Solar Cell Development. Geoffrey A. Landis,. NASA John Glenn Research Center. 21000 Brookpark Road, Cleveland, OH 44135. Danielle ...

185

Electron-induced luminescence and x-ray spectrometer development

A growing number of environmental toxicants found in pesticides, herbicides, and industrial solvents are believed to have deleterious effects on development by disrupting hormone-sensitive processes....Full Text Available

2003-04-01

186

Development of grid-connected photovoltaic systems

Jan 22, 2011 ... dc.description.abstract, The progress in the development of a surface analysis tool based on the excitation of characteristic luminescence ...

187

Development of a universal plate-agglutination test for detecting Haemophilus parasuis

The activities and the policy in the Netherlands regarding the development of the title systems since 1990 are briefly outlined, focusing on the use of PV-systems in buildings. 5 figs., 1 tab.

188

Development of a Long-Range Gliding Underwater Vehicle ...

Due to the serovar diversity in Haemophilus (H.) parasuis, it is difficult to develop a universal serological method for detection of this pathogen....Full Text Available

2010-12-01

189

Development of a FeCoNb Alloy to be used in Eddy Current ...

... investigates the convergence of three main areas of UUV development; mission ... with an improved low-cost embedded-system robot controller, to ...

2008-09-01

190

Development of High Field Dipole and High Current Pulse Power Supply for Compact Proton Synchrotron

... Accession Number : ADD336001. Title : Development of a FeCoNb Alloy to be used in Eddy Current Probes for Testing Ferromagnetic Tubes,. ...

191

Development of Grade API X80 Pipeline Steel Plates ...

Development of High Field Dipole and High Current Pulse Power Supply for Compact Proton Synchrotron

2003-01-01

192

Develop Magnetic Coil Design and Manufacturing Capability.

... Accession Number : ADD130998. Title : Development of Grade API X80 Pipeline Steel Plates Produced by Controlled Rolling,. Corporate Author : ...

193

Course, Curriculum, and Laboratory Improvement (CCLI)

... design, and manufacturing knowledge have been acquired and used to develop an 'in-house' capability for the fabrication of magnetic forming coils ...

1974-11-01

194

Copper deficiency alters the neurochemical profile of developing rat brain

... teaching and learning; Creating learning materials and teaching strategies; Developing faculty ... achieve educational innovations. Educational Materials Development (EMD): A project under the former ...

195

Advanced Technological Education Program: 1999 Awards and Activities

Copper deficiency is associated with impaired brain development and mitochondrial dysfunction. Perinatal copper deficiency was produced in Holtzman rats. In vivo proton NMR...Full Text Available

2009-06-01

196

[Transurethral resection in saline (TURis): a newly developed TUR system preventing obturator nerve reflex].

... By developing and disseminating educational materials and curricula, supporting the preparation and ... education, such as curriculum or educational materials development, faculty or teacher preparation ...

197

[Development of Eurytrema pancreaticum (Janson, 1889) (Trematoda: Dicrocoeliidae) in the Maritime Territory].

PMID:14671997

2003-11-01

198

Treating disaster as a development opportunity : a study of earthquake recovery in Sichuan

PMID:4786633

199

Norwegian Open Research Archives (NORA)

Full Text Available

200

The beaver's reconquest of Eurasia: status, population development, and management of a conservation success

Norwegian Open Research Archives (NORA)

Full Text Available

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201

The Economic Impacts of Pacific Ocean Deep-sea Manganese Nodule Development Project

Sustainability Network Letter 60E

Full Text Available

2010-12-01

202

Study on the Development of Solid Fuel of Animal Wastes for Heating of Agricultural Facilities

crucial to the survival of our species that our brains have developed an obsession with all things

203

Sheath development around a high voltage cathode in a glow discharge plasma

Full Text Available

2007-10-01

204

Secondary Titanium Processes

Short communication. 3 refs.

1991-02-04

205

Screening of Medicinal Plants for Development of Functional Food Ingredients with Anti-Obesity

Research and Development of Resource-Saving Technology for Manufacturing of Titanium Semifinished Items from Chips

206

Full Text Available

2006-09-01

207

Rubomycine Production

Review for free electron laser (FEL) development

Development of Experimental Large-scale Technology and Creation of Technological Line of Rubomicine Production

208

Radiation and fetal brain development

The authors have analysed the technical character of FEL, estimated its present status, developing trend and application prospect at home and abroad. Meanwhile the have also reviewed the significance of developing FEL, its position, role and difficulties. Finally the have presented some suggestions for FEL future developments in China.

209

Radial Halbach Magnetic Bearings

(4 Sep 1986). United Kingdom Zamenhof, Stephen . California Univ., Los

210

Radial Halbach magnetic bearings have been investigated as part of an effort to develop increasingly

2009-01-01

211

Pure Scandium Production

Porting to the Symbian Platform Open Mobile Development in C/C++

Development of the Technology to Obtain Pure Metal Scandium by Thermal Decomposition of Scandium Iodide

212

Planning and Operation of Commercial Application Center

Porting to the Symbian Platform

2009-01-01

213

Parallel expression of synaptophysin and evoked neurotransmitter release during development of cultured neurons

The objectives of this R and D project are as follows : First, transferring developed technologies to outside companies and operating technology market to vitalize technology transactions, Second, developing commercial application projects to transfer technologies for commercial purposes and to solve interface problems in commercial applications, Third, enhancing commercial utilizations of developed accelerator and beam utilization technologies, Finally. preparing infra-structures for the development of over 30 venture- businesses based on achieved technologies through the Proton Engineering Frontier Project.

2003-06-15

214

Oxygen Implanted Materials

Udgivelsesdato: 1991-null

1991-01-01

215

Online monitoring of pollen - development of a novel technique and first results of field experiments

Development of Oxygen Ion-Implanted Collector materials for Thermal Emission Converters of Thermal Energy into the Electric One.

216

On the Relationship between Typhoon Intensity and Formation Region: Effect of Developing and Decaying ENSO

No abstract prepared.

2005-07-01

217

Numerical investigation on developing laminar forced convective heat transfer and entropy generation in an annular helicoidal tube

Full Text Available

2008-02-01

218

Newly developed control and stop valves

Full Text Available

2011-06-01

219

... bwr type reactors closures fluidic control devices operation performance pwr

220

New Effective Pesticides

Nanomachines: How Viruses Work, and How We Can Stop Them

Development the New Effective Pesticides in the Series of Pyrimine and Sym-Triazine Derivatives

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

221

ScienceCinema

...the development of biomedicine ...

222

N7'5 20853

MICROSEISMICS AND GEOTECHNICAL APPLICATIONS

of fracture -stimulated geothermal reservoirs; 2) the development of ... of the mathematical simulation model of geothermal reservoirs. ...

223

Low-Temperature Neon Isotope Separation

... PRODUCTION OF TIGHT OIL-GAS BEARING ROCKS, AND IS ALSO EMPLOYED FOR THE DEVELOPMENT OF GEOTHERMAL RESERVOIRS. ...

1989-06-01

224

Isolation and Identification of Mycoplasmas

Development of a Plant for Neon Isotopes Separation by Low-Temperature Rectification Method

225

Investigations and development of gaseous radiation detectors; Badania i rozwoj konstrukcji gazowych detektorow promieniowania

Isolation and Identification of Mycoplasmas, Development of Reliable Antigen for Mycoplasmas Detection and Oil-Based Vaccines

226

No abstract prepared

1998-12-31

227

Inside - NASA

Inhibitory Activity of Advanced Glycation Endproducts (AGE) Formation of Edible Plants for Development of Anti-Wrinkle Ingredients

developed for our government and industrial robots were used by .... UUV capabilities, into a product. The licensing agreement and ...

228

Full Text Available

2010-02-01

229

India cleans up

Immunohistochemical expression of p63 in human prenatal tooth primordia

The paper discusses clean coal technology developments in India. 2 photos.

2011-01-15

230

Hudson Lecture for 1958 Darwinism in New Zealand: Some Examples, Influences and Developments

development, histochemical, human, malformation, p63 gene, tooth

2005-01-01

231

Transactions and Proceedings of the Royal Society of New Zealand 1868-1961

Full Text Available

1959-01-01

232

High-Performance SPICE Development Including an Analytical Transient Photocurrent BJT Model

FY2003 Laboratory Directed Research and Development Program Annual Report

No abstract prepared.

2000-08-01

233

Expression of microtubule associated protein of low molecular weight (TAU) in mouse brain development

No abstract prepared.

2004-07-30

234

Evaluation on corrosion environment at BWRs

Published in summary form only.

235

Environmental and resource economics in South Africa: status quo and lessons for developing countries

... Systems Research and Development Center, Yokohama, Kanagawa (Japan)

2009-05-01

236

CSIR Research Space (South Africa)

Full Text Available

237

Entomopathogenic Nematodes in Biological Control

Electrodepositing Nanostructured Composite Coatings

Commercial Production and Development, in Entomopathogenic Nematodes in Biological Control

238

Electrochemical Solar Energy Converter

Development of the Method of Electrodepositing Nanostructured Composite Coatings with Improved Engineering Properties

239

Effects of Concrete and Wood Building Environments on Pregnant Dams and Embryo-Fetal Development in Rats

Elaboration of Electrochemical Solar Energy Converter Incorporating Cadmium Selenide Semiconductor Developed Electrochemically

240

Effect of Low Night Temperature on Reproductive Organ Development in Relation to Pollen Viability of Bell Pepper

Full Text Available

2009-12-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

241

Education for Development in Underdeveloped Countries.

Full Text Available

2009-05-01

242

Ecologically Safe Luminescent Lamps

Past "elitist" development efforts modeled on Western academic education have failed to meet manpower needs but resist change due to popular preference for "modern" occupations. A new development strategy providing universal basic education and improved general living standards is needed. (Part of a theme issue on Third World educational development.) (SJL)

1981-06-01

243

Development of the Calorimeter to Measure Heat Rate Generated from Battery for EV & HEV

Development and Creation of Model Samples of Ecologically Safe Luminescent Lamps

244

Development of the Caliper System for a Geometry PIG Based on Magnetic Field Analysis

Full Text Available

1999-11-01

245

Development of the Automative Correction System for the Digital Over-current Relay With Distribution System

Full Text Available

2003-12-01

246

Development of coal utilization technology in the Japanese steel industry - co-operation with coal suppliers

Full Text Available

2007-04-01

247

Development of chemical separation in gas phase for heavy actinide and trans-actinide elements

Past and current development of coal utilization technology in the Japanese steel industry is reviewed and some projects currently under research and development briefly described. These include DIOS, an iron making process which directly utilizes both iron ore and coal without a sintering plant or a coke oven; and the development of a new generation coke oven. 15 figs.

1994-12-31

248

Development of an Active Magnetic Noise Shielding System for a Permanent Magnet Based MRI

No abstract prepared

1998-01-01

249

Development of a hardware in the loop simulation system for electric power steering in vehicles

Full Text Available

2003-05-01

250

Development of a fiber coupled, end pumped, Nd:YAG laser spark plug

Full Text Available

251

Development of a dual serial-parallel multiphase CFD code for application to industrial combustor/reactor systems.

None provided

2007-09-01

252

Development of a Wireless Vibration Monitoring System for Structural Health Evaluation

No abstract prepared.

2000-05-16

253

Development of a Standard Data Base and Computer ...

Full Text Available

2010-02-01

254

Development of Small-sized Gas Turbine Engine Control System for Power Generation

... (Author). Descriptors : (*TERMINAL FLIGHT FACILITIES ... PROGRAMMING, HANDLING), QUEUEING THEORY, STOCHASTIC PROCESSES ...

1973-01-01

255

Development of Single-Frame PIV Velocity Field Measurement Technique Using a High Resolution CCD Camera

Full Text Available

2011-08-01

256

Development of Regional Noodles Using Agricultural and Fishery Products of Cheju Island

Full Text Available

2000-01-01

257

Development of National Life Cycle Inventory Database on Irrigation Water by Agricultural Dam

Full Text Available

1996-08-01

258

Development of Multi-layer Electromagnetic wave Absorbers Using Sendust

Full Text Available

2011-05-01

259

Development of Location Estimation and Navigation System of Mobile Robots Using USN and LEGO Mindstorms NXT

Full Text Available

2006-10-01

260

Development of Lightweight Moving Table for Linear Motor using Composite Materials

Full Text Available

2010-03-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

261

Development of Estimation Model for Hysteresis of Friction Using Artificial Intelligent

Full Text Available

2010-04-01

262

Development of Broadband Electromagnetic Wave Absorber for X-band Sensors in Double-layered Type Using Carbon

Full Text Available

2011-07-01

263

Development and Fabrication of Compositions for 155-mm ...

Full Text Available

2006-12-01

264

Development and Evaluation of an e-Learning Program for Mothers of Premature Infants

... Descriptors : *PROPELLING CHARGES, *NITROCELLULOSE, *COMBUSTIBLE CARTRIDGE CASES, DENSITY, FIBERS, MANUFACTURING ...

1982-10-01

265

Development an Empirical Formula for the Friction Coefficient of a Circular Friction Damper

Full Text Available

2008-02-01

266

Degradation of leucine zipper-positive isoform of MYPT1 may contribute to development of nitrate tolerance.

Full Text Available

2011-06-01

267

DEVELOPMENT OF THE PILOT WARNING INSTRUMENT ...

PMID:19939965

2009-11-25

268

Corrosion Protection of special steels and alloys

... multivibrators and amplifiers arranged to operate as described above. ... The first of the multivibrators is triggered by the trailing edge of the ...

1962-02-01

269

Continuous Strategy Development for Effects-Based ...

Development of the Corrosion Protection Technology for Special Steels and Alloys

270

Combustion of Crop Production Wastes

... BAE Systems Advanced Information Technologies, Inc. APPROVED FOR PUBLIC RELEASE; DISTRIBUTION UNLIMITED. ...

2006-02-01

271

Chemical Reactor Diagnostics

Development, Investigation and Improvement of a System of Incinerating Crop Production Wastes in Small Capacity Boilers

272

Ceramic Composite Materials

Development of Methods and Apparatus for Processes Diagnostics in Plasma Reactors at the Neutralization of Chemical Herbiside and Pestiside

273

Boron-10 Materials Production

Development of Ceramic Composite Materials and Structural Elements for High-Temperature Nuclear Reactors

274

Biology-inspired Architecture for Situation Management

Development of Technologies for Boron-10 Isotope Modified Boron-containing Materials Production and their Properties Investigation.

275

Automated transport and sorting system in a large reference laboratory: part 1. Evaluation of needs and alternatives and development of a plan.

Situation Management is a rapidly developing science combining new techniques for data collection

2006-01-01

276

Antimicrobials in the Management of Post-Irradiation Infection

PMID:12324492

2002-10-01

277

A Study on Development of Electro Magnetic Wave Absorbers for Mobile Phones

... develops. An alternative approach is the use of non-absorbable antibiot- ics such as polymyxin, neomycin, and bacitracin. ...

2011-05-13

278

A Study of Magnetic Properties for Recycling of Laser Printer Developer Roller

Full Text Available

2006-05-01

279

A Report on the Evaluation of the NSF's Informal Science Education (ISE) Program

Full Text Available

2009-01-01

280

A Development of Visualization Software for Protective Engineering in Low-Voltage Power Systems

... science in places outside of schools, with materials and activities initially not developed for ...

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

281

Web-Based Enterprise Information Systems Development: The Integrated Methodology

Full Text Available

2006-07-01

282

Energy requirements for rural development

The paper considers software development issues for large-scale enterprise information systems (IS) with databases (DB) in global heterogeneous distributed computational environment. Due to high IT development rates, the present-day society has accumulated and rapidly increases an extremely huge data burden. Manipulating with such huge data arrays becomes an essential problem, particularly due to their global distribution, heterogeneous and weak-structured character. The conceptual approach to integrated Internet-based IS design, development and implementation is presented, including formal models, software development methodology and original software development tools for visual problem-oriented development and content management. IS implementation results proved shortening terms and reducing costs of implementation compared to commercial software available.

2006-01-01

283

Safeguards and Security Technology Development Directory. FY 1993

This study on the role of energy in the development of rural areas was originally conducted in the spring and summer of 1985. It was intended to serve as a background paper for the preparation of a program plan for the Office of Energy of the United States Agency for International Development. As such it begins with a brief overview of how rural development fits into national development, then offers a comprehensive framework for thinking about rural development in particular and the energy implications of the various components of rural development. Agriculture naturally comes to mind when rural areas are mentioned, but industry is an important component of rural activity as well. Consequently, both agricultural and nonagricultural energy use is discussed. Modernization of rural areas will change household, as well as production, energy use. However, household ...

1988-06-01

284

Guide to good practices for the development of test items

The Safeguards and Security Technology Development Directory is published annually by the Office of Safeguards and Security (OSS) of the US Department of Energy (DOE), and is Intended to inform recipients of the full scope of the OSS R&D program. It is distributed for use by DOE headquarters personnel, DOE program offices, DOE field offices, DOE operating contractors, national laboratories, other federal agencies, and foreign governments. Chapters 1 through 7 of the Directory provide general information regarding the Technology Development Program, including the mission, program description, organizational roles and responsibilities, technology development lifecycle, requirements analysis, program formulation, the task selection process, technology development infrastructure, technology transfer activities, and current research and development tasks. These chapters are followed ...

1993-06-01

285

Biotechnology developments in the livestock sector in developing countries.

While the methodology used in developing test items can vary significantly, to ensure quality examinations, test items should be developed systematically. Test design and development is discussed in the DOE Guide to Good Practices for Design, Development, and Implementation of Examinations. This guide is intended to be a supplement by providing more detailed guidance on the development of specific test items. This guide addresses the development of written examination test items primarily. However, many of the concepts also apply to oral examinations, both in the classroom and on the job. This guide is intended to be used as guidance for the classroom and laboratory instructor or curriculum developer responsible for the construction of individual test items. This document focuses on written test items, but includes information relative to ...

1997-01-01

286

The relationship between reclamation and sustainable economic development

Global meat and milk consumption is exponentially increasing due to population growth, urbanization and changes in lifestyle in the developing world. This is an excellent opportunity for developing countries to improve the livestock sector by using technological advances. Biotechnology is one of the avenues for improved production in the "Livestock revolution". Biotechnology developments applied to livestock health, nutrition, breeding and reproduction are improving with a reasonable pace in developing countries. Simple bio-techniques such as artificial insemination have been well implemented in many parts of the developing world. However, advanced technologies including transgenic plant vaccines, marker assisted selection, solid state fermentation for the production of fibrolytic enzymes, transgenic fodders, embryo transfer and animal cloning are confined largely to research ...

2010-01-01

287

Creative activity in conception of sustainable development education

The purpose is to define sustainable economic development in the context of nonrenewable resources and to examine the changing nature of reclamation over time. Sustainable development is development that ensures the present utilization of resources and the environment does not damage prospects for their use by future generations. Polls show that the public is demanding higher environmental standards. One mechanism for achieving sustainable economic development for the nonrenewable resource sector is through reclamation. The Alberta government`s approach to reclamation is reviewed to show how reclamation and sustainable government are linked together. The history of reclamation legislation in Alberta is summarized. 10 refs.

1991-06-01

288

British Library Electronic Table of Contents (United Kingdom)

Purpose - The purpose of this paper is to reflect on the stages in the development of creative activity considering the distinctive features of all stages and the modes of dynamics of the development of a creative person. Design/methodology/approach - The paper analyses scientific investigations and pedagogical experiences in order to develop the model for the formation of creative activity of artists-visual art teachers in the context of sustainable development. Findings - The investigations of scientific literature on pedagogy, psychology, philosophy, as well as the analysis of pedagogical practice allow us to recognize that the formation of creative activity is comprised of several stages. These stages are closely connected with a creative process and depend on a person's artistic talen...

2007-01-01

289

Toxic effects of lead on neuronal development and function

Sequential development of correlated projects: an application to coal liquefaction

The effects of lead on the development of the nervous system are of immediate concern to human health. While it is clear that lead can affect neuronal development at levels of exposure within the range found in the environment, the particular mechanism of the disruption is not readily ascertained. The goal of the authors research is to develop a model system in which the effects of lead on central nervous system development can be demonstrated. To study neuronal development in a system that minimizes such difficulties, the authors have grafted discrete brain regions derived from rat fetuses into the anterior chamber of the eye of adult hosts. The brain pieces continue organotypic development in the eye, but are isolated from possible secondary changes due to alterations in the development of the endocrine and other somatic systems because ...

1990-11-01

290

Organizational model of control of state of technology in the coal industry

A sequential research and development programme is considered for which several categories of related technologies are available to develop, each having the potential to produce some final product. At each stage of the programme, an optimal portfolio of technologies is chosen given the information acquired from the previous stages, and those contingent optimal plans are followed in all subsequent stages. The model is applied to coal liquefaction technologies to emphasize the costs that may be incurred by erroneously approaching the development programme as a once-and-for-all endeavour rather than in a sequential framework. The results of the synthetic oil application indicate that the acceleration of the programme may be optimal when the probability of successful development decreases. Under these conditions, adoption of a 'crash programme' in which all projects are researched ...

1983-01-01

291

Development of in-vessel reflood instrumentation at ORNL

This paper discusses organizational models of planning technology development in coal mining. The following 4 planning systems are analyzed: all-union national system coordinated by the Ministry of Coal Mining of the USSR, all-union associations of coal mine associations (in the Ukrainian SSR the plan is developed by the Ministry of Coal Industry of the Republic), associations of coal mines, coal mines or groups of coal mines. Methods for developing programs for technology development at 4 levels are reviewed. The following planning periods are used: 10 years or more (from 1980 to 1990), a 5 year period and a 1 year period. System for technology development in the Soviet coal industry from 1981 to 1985 is evaluated: research and development programs (20 comprehensive state programs, 36 branch programs). (In Russian)

1984-02-01

292

Development of Control Design Scheme Using Nonlinear Analysis

A program under the sponsorship of the United States Nuclear Regulatory Commission was intiated at the Oak Ridge National Laboratory (ORNL) in late 1977. The program, Advanced Instrumentation for Reflood Studies (AIRS), is charged with developing instrumentation for measurement of in-vessel fluid phenomena in pressurized water reactor reflood facilities. The goal of the ORNL program is to develop techniques and systems for measuring fluid flow in-core, deentrainment in the upper plenum and liquid fallback from the upper plenum into the core. A large portion of the development at ORNL is devoted to the impedance probes for measurement of two-phase flow velocities and void fractions. Film probe development at ORNL is limited to adapting the present techniques to the environment of a reflood facility. As the development progresses on all the measurement techniques, ORNL will fabricate ...

2004-09-06

293

Virtual adult ears reveal the roles of acoustical factors and experience in auditory space map development

Phenomena in power systems tend to exhibit higher nonlinearity, because efficient operation accompanies severer power transfer. In such cases, there might exist some limitation to the use of conventional linear control design scheme due to the nonlinearity. As for consideration to the nonlinearity, we have developed a nonlinear analysis method based on normal form theory. In this paper, we develop a new control design scheme based on the nonlinear analysis method. The developed method is effective in a case when oscillatory instability occurs. In the developed method, the parameters of control devices are adjusted so as to enlarge the stability limit against the oscillatory instability, unless each eigenvalue exceed its allowable threshold. We verify the effectiveness of the developed method in the IEEJ 10-machine System Model by applying to PSS (Power System Stabilizer). We show ...

2007-01-01

294

Uneven dietary development: linking the policies and processes of globalization with the nutrition transition, obesity and diet-related chronic diseases

Auditory neurons in the superior colliculus (SC) respond preferentially to sounds from restricted directions to form a map of auditory space. The development of this representation is shaped...Full Text Available

2008-11-05

295

Undergraduate Course and Curriculum Development Program and Curriculum Development in Mathematics: Calculus and the Bridge to Calculus 1994 Awards

In a "nutrition transition", the consumption of foods high in fats and sweeteners is increasing throughout the developing world. The transition, implicated in the rapid rise of obesity and diet-related...Full Text Available

296

The influence of MHC polymorphism on the selection of T-cell determinants of FMDV in cattle.

... such as biology, physics, geology, materials science, engineering, computer science, and mathematics ... expected to produce course and curricular materials that will be of national interest and widely ...

297

The development and validation of the daily electronic Endometriosis Pain and Bleeding Diary

There is a quest for the development of a new generation of vaccines consisting of well-defined subunit antigens. For a number of practical reasons it is attractive to develop vaccines on the basis...Full Text Available

1995-01-01

298

The Role of Thyroid Hormone in Testicular Development and Function

BackgroundThe objective of this study was to develop and validate a daily electronic Endometriosis Pain and Bleeding Diary (EPBD) for assessing treatment-related changes in endometriosis...Full Text Available

299

The Notochord, Notochordal cell and CTGF/CCN-2: ongoing activity from development through maturation

Thyroid hormone is a critical regulator of growth, development and metabolism in virtually all tissues, and altered thyroid status affects many organs and systems. Although for many years testis...Full Text Available

2008-12-01

300

Terminal-differential algorithm for identification of local non homogeneity in article

The growth regulating factor CTGF/CCN-2 is an integral factor in growth and development, connective tissue maintenance, wound repair and cell cycle regulation. It has recently been reported that CTGF/CCN-2...Full Text Available

2008-12-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

301

Research and development for the upgrading of Rhenish brown coal

Terminal-differential algorithm for identification of local nonhomogeneities in items under control is developed on the basis of measurements of X-ray or gamma-radiation weakening. The algorithm may be applied by developing radiation schemes of nondestructive control, identifying inadmissible inclusions in the object under study

302

Rapid Onset of Maternal Vocal Recognition in a Colonially Breeding Mammal, the Australian Sea Lion

Product control procedures, the development of new technologies, and the extension of the applications of solid fuels are described. Hydrogasification and high-temperature Winkler gasification are discussed. The design and function of a continuous, semi-industrial plant for hydrogenating liquefaction in the sump phase are gone into. (MOS).

1988-07-01

303

REM Sleep Percentage in Children with Autism Compared to Children with Developmental Delay and Typical Development

BackgroundIn many gregarious mammals, mothers and offspring have developed the abilities to recognise each other using acoustic signals. Such capacity may develop at different rates...Full Text Available

304

Propranolol ameliorates the development of portal-systemic shunting in a chronic murine schistosomiasis model of portal hypertension.

ObjectiveTo compare objective polysomnographic parameters between three cohorts: children with autism, with typical development, and with developmental delay without...Full Text Available

2010-11-01

305

Proof-of-concept Design and Development of an EN13606-based Electronic Health Care Record Service

We investigated the role of early portal hypotensive pharmacotherapy in preventing the development of portal-systemic shunting in a portal hypertensive model of chronic murine schistosomiasis induced...Full Text Available

1991-03-01

306

Progress report on negative ion beams based on User Development Workshop on negative ion based neutral beams, 15-16 February, 1983, Princeton

ObjectiveThe authors present an Electronic Healthcare Record (EHR) server, designed and developed as a proof of concept of the revised prEN13606:2005 European standard concerning...Full Text Available

2007-01-01

307

Pattern formation and traveling waves in myxobacteria: Theory and modeling

Progress in the development of negative ion sources and their application in fusion research is reviewed. (U.K.).

1983-04-18

308

PDP-1 Links the TGF-? and IIS Pathways to Regulate Longevity, Development, and Metabolism

Recent experiments have provided new quantitative measurements of the rippling phenomenon in fields of developing myxobacteria cells. These measurements have enabled us to develop a mathematical model...Full Text Available

2001-12-18

309

Numerical Weather Prediction Activities Report.

The insulin/IGF-1 signaling (IIS) pathway is a conserved regulator of longevity, development, and metabolism. In Caenorhabditis elegans IIS involves activation of DAF-2 (insulin/IGF-1...Full Text Available

2011-04-01

310

Nuclear raw materials: Developing resources through technical co-operation

This report presents a summary of highlights of the year 1978. It then discusses: Research and development in numerical analysis and prediction systems; Techniques, development and application of new products; Analysis-forecast systems in operation use du...

1978-01-01

311

Malate- and Pyruvate-Dependent Fatty Acid Synthesis in Leucoplasts from Developing Castor Endosperm 1

This article presents an overview of the IAEA's technical co-operation activities in the field of nuclear raw materials, particularly looking at recent developments and trends influencing future directions

1993-09-01

312

Localisation of glycoproteins and glycosaminoglycans during early eye development in the macaque.

Leucoplasts were isolated from the endosperm of developing castor (Ricinis communis) endosperm using a discontinuous Percoll gradient. The rate of fatty acid synthesis was highest...Full Text Available

1992-04-01

313

Investigation of the semicrystalline morphology development in polymeric blends of thermoplastic polyesters, PET/PBT and PET/PC, through optical microscopy development, DSC and SAXS/WAXD/DSC with synchrotron radiation

The composition of the extracellular matrix (ECM) was examined in the developing lens and optic cup (stages 11-16) of the long-tailed monkey (Macaca fascicularis) using peroxidase immunocytochemistry....Full Text Available

1995-02-01

314

Intensity modulated radiotherapy: advantages, limitations and future developments

Portuguese 2007 p. 136 Brazil Barbosa Junior, IB Larocca, NM Hage Junior,

2007-02-12

315

Insulin receptor signaling in the development of neuronal structure and function

Intensity modulated radiotherapy (IMRT) is widely used in clinical applications in developed countries, for the treatment of malignant and non-malignant diseases. This technique uses multiple radiation...Full Text Available

316

High Speed Cylindrical Roller Bearing Development.

Sensory experience plays a crucial role in regulating neuronal shape and in developing synaptic contacts during brain formation. These features are required for a neuron to receive, integrate, and transmit...Full Text Available

317

Germ cell sex determination in mammals

High speed experimental tests provided data on six parametric cylindrical roller bearings. Four bearing variables were evaluated and the results were correlated with the analytical model developed under Naval Air Propulsion Center Contract N00140-76-C-038...

1980-01-01

318

One of the major decisions that germ cells make during their development is whether to differentiate into oocytes or sperm. In mice, the germ cells’ decision to develop as male or female depends...Full Text Available

2009-04-01

319

Geothermal status report

GSFC Information Systems Technology Developments Supporting the Vision for Space Exploration.

This article examines the effects of competition of geothermal energy production with other technologies. The topics of the article include near-term market growth, cause for cautious optimism, limits to development of geothermal energy production, economic arguments for development of geothermal power plants, the effects of a competitive market on industry survival.

320

From Leningrad to the day-care center. The ubiquitous Giardia lamblia.

The Vision for Space Exploration will guide NASA's future human and robotic space activities. The broad range of human and robotic missions now being planned will require the development of new system-level capabilities enabled by emerging new technologie...

2005-01-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

321

Free and Conjugated Indole-3-Acetic Acid in Developing Bean Seeds ¹

Giardiasis is recognized as a worldwide public health problem. Seroprevalence data from both the developing and developed world show high rates of carriage in populations at risk for fecal-oral transmission,...Full Text Available

1990-08-01

322

Forschungszentrum Juelich, Institut fuer Kernphysik/COSY. Annual report 2004

The changes in conjugated indole-3-acetic acid (IAA) levels compared to the levels of free IAA have been analyzed during the development of bean (Phaseolus vulgaris L.) seed using quantitative...Full Text Available

1989-10-01

323

Final Report on the Evaluation of the NSF's Instructional Materials Development Program

The following topics are dealt with: Detectors at COSY, major physics results at COSY, physics at external facilities, theoretical investigations, COSY operation and developments, preparations for FAIR, technical developments. (HSI)

2005-03-01

324

Factors Predicting and Reducing Mortality in Patients with Invasive Staphylococcus aureus Disease in a Developing Country

... of the Evaluation of the Instructional Materials Development Program (PDF, 412 kb) Chapter I ... kb) Appendix 2: Instrument for Evaluating Materials (PDF, 935 kb) Appendix 3: Classroom Observation ...

325

Executive Development Journeys The Essence of Customized Programs

BackgroundInvasive Staphylococcus aureus infection is increasingly recognised as an important cause of serious sepsis across the developing world, with mortality...Full Text Available

326

Evaluation of tilted cone-beam CT orbits in the development of a dedicated hybrid mammotomograph

Summarizing the three main reasons why customized programs are commissioned, this book explains and explores the key aspects of successful development programs, with views from corporate sponsors, participants, faculty contributors and case studies of customised programs commissioned by 6 organizations

2010-01-01

327

Evaluation of one-pile foundations for wind turbines. Beoordeling van eenpaalsfundaties voor windturbines

A compact dedicated 3D breast SPECT-CT (mammotomography) system is currently under development. In its initial prototype, the cone-beam CT sub-system is restricted to a fixed-tilt circular rotation...Full Text Available

2009-06-21

328

Energizing the batteries for electric cars

A procedure has been developed for judging one-pile foundations for wind turbines. It appears that these foundations are good alternatives for block foundations. It is recommended to develop a program for testing one-pile foundations and to carry out a further research into their dynamic behavior.

1986-01-01

329

Endogenous expression of Hras^G12V induces developmental defects and neoplasms with copy number imbalances of the oncogene

This article reports of the nickel-metal-hydride battery and its ability to compete with the lead-acid battery in electric-powered vehicles. The topics of the article include development of the battery, the impetus for development in California environmental law, battery performance, packaging for the battery's hazardous materials, and the solid electrolyte battery.

1993-07-01

330

Effect of physiological levels of caffeine on Ca²⁺ handling and fatigue development in Xenopus isolated single myofibers

We developed mice with germline endogenous expression of oncogenic Hras to study effects on development and mechanisms of tumor initiation. They had high perinatal mortality, abnormal...Full Text Available

2009-05-12

331

Economic and financial issues relating to renewable energy systems in developing countires

The purpose of the present study was to determine whether exposure to exogenous physiological concentrations of caffeine influence contractility, Ca²⁺ handling, and fatigue development...Full Text Available

2009-05-01

332

EARLY FLOWERING3 Encodes a Novel Protein That Regulates Circadian Clock Function and Flowering in Arabidopsis

The problems of introducing renewable energy systems into communities having meagre resources are analysed. Topics covered include financial and economic barriers, subsidies and bank policy. It is concluded that without satisfactory financing mechanisms, renewable energies are unlikely to be widespread in the developing world. (UK)

1995-12-31

333

EARLY BILATERAL SENSORY DEPRIVATION BLOCKS THE DEVELOPMENT OF COINCIDENT DISCHARGE IN RAT BARREL CORTEX

Higher plants use photoperiodic cues to regulate many aspects of development, including the transition from vegetative to floral development. The EARLY FLOWERING3 (ELF3)...Full Text Available

2001-06-01

334

Downstream genes of Pax6 revealed by comprehensive transcriptome profiling in the developing rat hindbrain

Several theories have proposed a functional role for synchronous neuronal firing in generating the neural code of a sensory perception. Synchronous neural activity develops during a critical...Full Text Available

2009-02-25

335

Developments of heavy-ion gas detectors at LNL

BackgroundThe transcription factor Pax6 is essential for the development of the central nervous system and it exerts its multiple functions by regulating the expression of downstream...Full Text Available

336

Development of rat CA1 neurones in acute Versus organotypic slices: role of experience in synaptic morphology and activity

The most important developments in gaseous detectors at LNL are reviewed. Some aspects of timing, pulse height and position resolutions of avalanche counters are reported. The experimental work on heavy-ion identification by Bragg curve spectroscopy is summarized.

1984-05-01

337

Development of engineered structural barriers for nuclear-waste packages

Despite their wide use, the physiological relevance of organotypic slices remains controversial. Such cultures are prepared at 5 days postnatal. Although some local circuitry remains intact, they develop...Full Text Available

2003-07-01

338

Development of an Interference Electron Microscope.

The development of structural barriers for nuclear waste packages involves selection of candidate materials, their screening by mechanical and corrosion testing, rigorous accelerated testing, and evaluation and comparison with other package elements. This document presents results from work conducted on titanium and ferrous alloys.

1981-09-01

339

Development of a physiologically based pharmacokinetic model of trichloroethylene and its metabolites for use in risk assessment.

This report covers a further year's work on the development of an Interference Electron Microscope at Imperial College. The instrument is unlike others of its type which have been operated. The basic innovations are to produce the critical illumination co...

1967-01-01

340

Development of a coal fired pulse combustor for residential space heating. Technical progress report, October--December 1986

A physiologically based pharmacokinetic (PBPK) model was developed that provides a comprehensive description of the kinetics of trichloroethylene (TCE) and its metabolites, trichloroethanol (TCOH),...Full Text Available

2000-05-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

341

Development of a Novel Post-processing Treatment Planning Platform for 4D Radiotherapy

This progress report presents a detailed description of the background, technology and application, and Statement of Work for the development of a coal-fired pulse combustor for residential space heating.

1986-12-31

342

Development and evaluation of a virtual microscopy application for automated assessment of Ki-67 expression in breast cancer

The aim of this study is to develop an Automatic Post-processing Tool for four-dimensional (4D) treatment planning (APT4D) that enables the user to perform some necessary procedures related...Full Text Available

2008-04-01

343

Development and Validation of the Convalescence And Recovery Evaluation (CARE) for Measuring Quality of Life after Surgery

BackgroundThe aim of the study was to develop a virtual microscopy enabled method for assessment of Ki-67 expression and to study the prognostic value of the automated analysis in...Full Text Available

344

Development and Application of Pathovar-Specific Monoclonal Antibodies That Recognize the Lipopolysaccharide O Antigen and the Type IV Fimbriae of Xanthomonas hyacinthi

PurposeTo develop a generic instrument for measuring short-term health status in the recovery period among patients undergoing abdominal and pelvic surgery.Full Text Available

2008-08-01

345

Development Document for Proposed Effluent Limitations Guidelines and Standards for the Concentrated Aquatic Animal Production Industry Point Source Category.

The objective of this study was to develop a specific immunological diagnostic assay for yellow disease in hyacinths, using monoclonal antibodies (MAbs). Mice were immunized with a crude cell wall preparation...Full Text Available

1999-09-01

346

Development Document for Proposed Effluent Limitations Guidelines and New Source Performance Standards for the Ore Mining and Dressing: Point Source Category.

This section presents background information supporting the development of effluent limitations guidelines and standards for the concentrated aquatic animal production (CAAP) point source category. Section 1.1 presents the legal authority to regulate the ...

2002-01-01

347

This document presents the findings of an extensive study of the ore mining and dressing industry, for the purpose of developing effluent limitations guidelines for existing point sources and standards for performance new sources, to implement Sections 30...

1982-01-01

348

Defect modelling

Critical periods of vulnerability for the developing nervous system: evidence from humans and animal models.

Calculations, drawing principally on developments at AERE Harwell, of the relaxation about lattice defects are reviewed with emphasis on the techniques required for such calculations. The principles of defect modelling are outlined and various programs developed for defect simulations are discussed. Particular calculations for metals, ionic crystals and oxides, are considered. (UK).

1980-03-01

349

Combining Google Earth and GIS mapping technologies in a dengue surveillance system for developing countries

Vulnerable periods during the development of the nervous system are sensitive to environmental insults because they are dependent on the temporal and regional emergence of critical developmental processes...Full Text Available

2000-06-01

350

Chagas disease: an impediment in achieving the Millennium Development Goals in Latin America

BackgroundDengue fever is a mosquito-borne illness that places significant burden on tropical developing countries with unplanned urbanization. A surveillance system using Google...Full Text Available

351

Calcitriol but no other metabolite of vitamin D is essential for normal bone growth and development in the rat.

BackgroundAchieving sustainable economic and social growth through advances in health is crucial in Latin America within the framework of the United Nations Millennium Development...Full Text Available

352

Biobank resources for future patient care: developments, principles and concepts

To determine the relative importance of different metabolites of vitamin D in bone growth and development, weanling male rat pups suckled by vitamin D-deficient mothers were given either calcitriol...Full Text Available

1984-02-01

353

Barotrauma developed during intra-hospital transfer -A case report-

The aim of the overview is to give a perspective of global biobank development is given in a view of positioning biobanking as a key resource for healthcare to identify new potential markers that can...Full Text Available

354

Astrocyte-Derived Vascular Endothelial Growth Factor Stabilizes Vessels in the Developing Retinal Vasculature

A 74-year-old male patient receiving ventilatory support due to aspiration pneumonia developed bilateral pneumothorax, pneumopericardium, pneumomediastinum, pneumo-retroperitoneum, and subcutaneous...Full Text Available

2010-12-01

355

Association of Thyroid Hormone Concentrations with Levels of Organochlorine Compounds in Cord Blood of Neonates

Vascular endothelial growth factor (VEGF) plays a critical role in normal development as well as retinal vasculature disease. During retinal vascularization, VEGF is most strongly expressed by not yet...Full Text Available

356

Angiotensin II Promotes Development of the Renal Microcirculation through AT₁ Receptors

BackgroundThyroid hormones are important regulators of brain development. During critical periods of development, even transient disorders in thyroid hormone availability may lead...Full Text Available

2007-12-01

357

Analysis of the Development of the Nasal Septum according to Age and Gender Using MRI

Pharmacologic or genetic deletion of components of the renin-angiotensin system leads to postnatal kidney injury, but the roles of these components in kidney development are unknown. To test the hypothesis...Full Text Available

2010-03-01

358

Analysis of target cell susceptibility as a basis for the development of a chemoprotective strategy against benzene-induced hematotoxicities.

ObjectivesThis study was designed to evaluate the normal development of the nasal septum in Koreans using sagittal MRI for the valuable clinical information on septal procedures.MethodsTwo...Full Text Available

2008-03-01

359

An outline of the Sunshine Project in 1982

A goal of our research is to identify biochemical factors that underlie the susceptibility of bone marrow cell populations to benzene metabolites so as to develop a mechanistically based chemoprotective...Full Text Available

1996-12-01

360

Agricultural R&D, technology and productivity

The Sunshine Project of Japan was inaugurated in 1974. Since 1980 it has been promoting priority projects such as coal liquefaction. Japan is now promoting the basic and applied research that underpins this development and is increasing the efficiency of technical development. With regard to risk dispersion, the expansion of international cooperation such as the IEA is being promoted.

1982-01-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

361

Adapting developing country epidemiological assessment techniques to improve the quality of health needs assessments in developed countries

The relationships between basic and applied agricultural R&D, developed and developing country R&D and between R&D, extension, technology and productivity growth are outlined....Full Text Available

2010-09-27

362

Acetylsalicylic acid as soluble tablets

BackgroundWe were commissioned to carry out three health assessments in urban areas of Dublin in Ireland. We required an epidemiologically robust method that could collect data rapidly...Full Text Available

363

Acetolactate Synthase Activity in Developing Maize (Zea mays L.) Kernels

Realization of Pharmacological Tests, Development of the Specifications and Technical Documentation and Registration in the Russian Federation of Medical Products as Soluble Tablets of Acetylsalicylic Acid/Calcium Carbonate in Two Dosages Intended for use as Medical Products Smoothing, Febrifugal and Antiaggregation Action and Development of Technology of Tableting the Above-Stated Preparations

364

A model of personality change after traumatic brain injury and the development of the Brain Injury Personality Scales

Acetolactate synthase (EC 4.1.3.18) activity was examined in maize (Zea mays L.) endosperm and embryos as a function of kernel development. When assayed using unpurified homogenates,...Full Text Available

1988-01-01

365

A conserved switch in sensory processing prepares developing neocortex for vision

ObjectiveThe aims of this study were to develop models of personality change after traumatic brain injury (TBI) based on information provided by the TBI survivor and a significant...Full Text Available

2007-11-01

366

A Comparison of the Metabolic Fate of Fatty Acids of Different Chain Lengths in Developing Oilseeds

Developing cortex generates endogenous activity that modulates the formation of functional units, but how this activity is altered to support mature function is poorly understood. Using recordings...Full Text Available

2010-08-12

367

45 CFR 1304.24 - Child mental health.

To determine if medium and long chain fatty acids can be appropriately metabolized by species that normally produce 16 and 18 carbon fatty acids, homogenates of developing Cuphea wrightii, Carthamus...Full Text Available

1989-07-01

368

Washington: a guide to geothermal energy development

... 2010-10-01 false Child mental health. 1304.24 Section 1304.24 Public...HUMAN DEVELOPMENT SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES THE ADMINISTRATION...AGENCIES Early Childhood Development and Health Services § 1304.24 Child...

2010-10-01

369

Vacuum Packaging for Microelectromechanical Systems ...

A brief overview is given of the geological characteristics of each region of the state as they relate to potential geothermal development. Those exploration methods which can lead to the siting of a deep exploration well are described. Requirements and techniques needed for drilling deeper higher temperature exploration and production wells are presented. Electrical generation, direct utilization, and indirect utilization are reviewed. Economic factors of direct use projects are presented. A general guide to the regulatory framework affecting geothermal energy development is provided. The general steps necessary to gain access to explore, develop, distribute, and use geothermal resources are outlined. (MHR)

1980-01-01

370

Update of the Navy Contract Writing Guide

... more than expected in developing a unique bond strength measurement protocol that is important for a wide range of bond strength measurements. ...

2002-10-01

371

Untitled - NASA Technical Report Server (NTRS)

... These requirements may be expressed in terms of MIL-STD-2073-1, DoD Material Procedures for Development and Application of Packaging ...

2004-06-01

372

Tritium Oxide Content Control

Directional audio technology for headphone applications is being developed. A laboratory demonstration model of a real-time digital ...

373

Trauma Patient Followup Registry

Development of Method and Technical Project of the Plant for Thermo-Vacuum Desorption of Tritium Oxide (HTO) from the Environmental Samples

374

Thermally developing flow in curved square ducts with internal fins

... Abstract : The goal of this project has been to explore and document the information management capabilities needed to develop a transportable ...

1987-07-31

375

Theme and policy for international development of Japanese nuclear energy industries

The laminar incompressible hydrodynamically fully developed and thermally developing flow is studied in a curved square duct with four longitudinal fins. The duct is successively subjected to constant wall temperature, to circumferentially uniform temperature and axially linearly or exponentially varying temperature. The local and fully developed Nusselt numbers are examined for various values of the Dean number and it is found that the heat transfer rate increases for high fins. The parameters that affect the entry length are studied and the fluctuations of the local Nu that appear in the entrance region are investigated. Temperature contour plots are presented for the visualization of the temperature field and functional relations for the Nusselt number are proposed in terms of the Dean and Prandtl numbers. (orig.)

2005-11-01

376

The impact of core flow rate on the water chemistry and corrosion in boiling water reactors

Aug 2010 p. 31-35 Japan Kishioka, Kazuhiko Japan Atomic Industrial Forum,

2010-08-01

377

The challenge of implementing an IRP process in Asia: The case of Hainan Province, China

... Development Center, National Tsing-Hua University, Hsinchu, TW (China)

2008-05-01

378

The New Pacific Security Environment: Challenges and ...

Developing a modern electric power sector is necessary for economic growth and development to proceed. Institutions to implement an IRP (integrated resource planning) process do not exist in many countries. Hainan`s economy is growing rapidly with a concomitant increase in electricity demand. This is an ideal time in Hainan`s development to implement an IRP process. The challenge is for Hainan to develop institutions and incentive mechanisms for HEPCO (Hainan Electric Power Co.) to adopt cost-based pricing, run DSM programs, construct renewable generating plants, etc. One proposal is to great a Hainan government-wide IRP committee.

1994-12-31

379

The National Shipbuilding Research Program, 1992 Ship ...

... The Taiwanese business community is inter- ested in developing access to potential markets as well as to sources of raw materials and some ...

2011-05-13

380

The Influence of pH on the Color Development of Melanoidins Formed from Fructose/Amino Acid Enantiomer Model Systems

... Development Document for Proposed Effluent Limitations Guidelines and Standards for the Shipbuilding and Repair Point Source Category (Draft ...

1992-09-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

381

THEORY AND DESIGN CONSIDERATIONS IN DEVELOPING ...

Full Text Available

2008-12-01

382

Sunflower power system test report topical report, nov. - 19 dec. 1962

... folgen. Die notwendigen Sch~ritte -an isotherme Verh~ltnisce an den, von der Versuchssubstanz benetzten Wandungen, zu ...

1966-09-01

383

Strategic Communication and the Combatant Commander

Sunflower power conversion system development test program

1964-01-01

384

... for International Development representatives. 3. If there is SC policy guidance, use it. If not, ask for it. In many cases, summaries ...

2009-10-01

385

Steam turbines

The author gives the historical development of steam-turbine construction in Europe since the turn of the century, and the technical further development of conventional turbines due to the increases in the steam parameters and per-unit outputs in the increases in the steam parameters and per-unit outputs in Europe and the USA. Marginal conditions for the development of turbines in nuclear power stations with light-water reactors are mentioned. The rise in the per-unit capacities of the turbosets constructed in Germany and the USA for nuclear power stations is discussed. Longitudinal sections through typical turbines are shown. The future development of turbines with high output is dealt with. (orig.).

386

Steam turbines

Spectroscopy, colorimetry, and biological chemistry in the nineteenth century.

A report is given on the development and operational experience in steam turbines in an annual review. The author refers to an extensive bibliography on this subject. (TK/LH).

387

Shock and Impact Response of Naval Composite Structures

The development of colorimetry and spectroscopy in the nineteenth century is described. An account is given of the application of their techniques to biological chemistry during that period.

1981-03-01

388

Separator Plates with Metal Felt Insertions

... at the end of this report. A. Low-Velocity Impact of Composite Sandwich Panels In 2007, the PI developed analytical solutions ...

2010-08-09

389

Self-Propagating High-Temperature Synthesis Technologies

Development of Bipolar Separator Plates with Porous Insertions of Metal Felt as Bearing Surfaces for Fuel Cell Electrodes

390

SAMS Research and Development

Development of SHS-technologies for SiC, Si3N4 and Ceramic Composites on Their Basis from Rocks

391

Release 01-93 - NASA Human Space Flight

... resolution video. RESULTS Statistics describing the typical inertial navigation error growth were collected. Typical errors ...

2008-08-06

392

RXTE Catches Morphing Magnetar

These cutting-edge developments will be used for future government and commercial launch systems and space transportation operations. ...

393

R&D prioritization and resource management for technology selection

This exciting new development in neutron star evolution was presented at the Winter 2004 AAS Meeting in Atlantia,Georgia. ...

394

This paper presents a decision approach, and associated computer software tools, for prioritizing and selecting among technology development activities. The approach elicits and then summarizes technology development preferences from stakeholders, and then integrates preferences into a set of funding recommendations. By formalizing the technology review process, the decision approach builds consensus and clarifies the basis for final budget decisions. The software development was conducted jointly by Pacific Northwest Laboratory and Decisions Science Associates, Incorporated. The Underground Storage Tank Integrated Demonstration funded the task; however, the approach should also be valuable to the US Department of Energy Office of Technology Development, the Office of Waste Management, and the Office of Environmental Restoration.

1994-03-01

395

PowerPoint Presentation

Performance Testing Methodology for Safety-Critical Programmable Logic Controller

facilities, building hygienic latrines and introducing regular solid waste collection systems . These methods are constantly being developed and

396

Overview of US LMFBR Structural Materials Mechanical Properties Program

The Programmable Logic Controller (PLC) for use in Nuclear Power Plant safety-related applications is being developed and tested first time in Korea. This safety-related PLC is being developed with requirements of regulatory guideline and industry standards for safety system. To test that the quality of the developed PLC is sufficient to be used in safety critical system, document review and various product testings were performed over the development documents for S/W, H/W, and V/V. This paper provides the performance testing methodology and its effectiveness for PLC platform conducted by KOPEC

2009-05-01

397

Overview of U.S. LMFBR structural materials mechanical properties program

This paper presents the objective, scope, and status of the US Department of Energy's Materials and Structures Program to develop a data base on mechanical properties of structural materials for out-of-core structures and components for LMFBRs. Information on the development of a reference data base on materials for the reactor system, reactor enclosure system, primary heat transport system, intermediate heat transport system, and steam generator system is included. In addition, the development of the data and analyses to account for the effects of temperature and stress, as well as water/steam, sodium, and radiation environments, is described. Plans for the development of alternative materials for future out-of-core applications are presented.

1983-01-01

398

New developments in the surveillance and diagnostics technology for vibration, structure-borne sound and leakage monitoring systems

This paper presents the objective, scope, and status of the U.S. Department of Energy's Materials and Structures Program to develop a data base on mechanical properties of structural materials for out-of-core structures and components for LMFBRs. Information on the development of a reference data base on materials for the reactor system, reactor enclosure system, primary heat transport system, intermediate heat transport system, and steam generator system is included. In addition, the development of the data and analyses to account for the effects of temperature and stress, as well as water/steam, sodium, and radiation environments, is described. Plans for the development of alternative materials for future out-of-core applications are presented. (author).

1983-10-10

399

Monitoring and diagnostic systems are of main importance for a safe and efficient operation of nuclear power plants. The author describes new developments with respect to vibration monitoring with a functional extension in the time domain for den secondary circuit, the development of a local system for the surveillance of rotating machines, the structure-borne sound monitoring with improvement of event analysis, esp. the loose part locating, leakage monitoring with a complete system for humidity measurement, and the development of a common platform for all monitoring and diagnostic systems, that allows an efficient access for comparison and cross references.

400

NRL Fact Book 2010

... Tactical Electronic Warfare Division (Code 5700) Visualization Laboratory Transportable step frequency radar Vehicle development laboratory ...

2011-05-15

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

401

NRL Fact Book

NASA/BAE SYSTEMS SpaceWire Effort

... Tactical Electronic Warfare Division (Code 5700) Visualization Laboratory Transportable step frequency radar Vehicle development laboratory ...

2011-05-15

402

More iPhone Cool Projects

This paper discusses the state of the NASA and BAE SYSTEMS developments of SpaceWire. NASA has

2003-01-01

403

Magnetic resonance imaging in childhood epilepsy

Everyone is developing iPhone applications, and it's clear why. The iPhone is the coolest mobile device available, and the App Store makes it simple to get an application out into the unstoppable iPhone app market. With hundreds of thousands of app developers entering the game, it's crucial to learn from those who have actually succeeded. This book shows you how some of the most innovative and creative iPhone application developers have developed cool, best-selling apps. Not only does every successful application have a story, but behind every great app is excellent code. In this book, you'll

2010-01-01

404

Lunar Communication & Navigation Architecture

The suitability of MR imaging versus computerized tomography in observation of brain development disorders in children are compared. 13 refs.

405

Prior to this at TRW, Mr. Schier managed flight software development on the MILSTAR Communications Payload and led integration and verification work on ...

406

Low-Cost Crystal Silicon

Liquid nitrogen dewar for protein crystal growth

The Development of Basic Plasma-Chemical Technology for Manufacture of Low Cost Crystal Silicon for Solar Power Plants.

407

Keratoconus: Frequently Asked Questions

Gaseous Nitrogen Dewar apparatus developed by Dr. Alex McPherson of the University of California,

2001-01-01

408

JPRS Report, Nuclear Developments

... a new cornea? As many of you know stem cell research and efforts to develop a replacement cornea have ...

409

Investigating Models of Social Development Using a ...

... II. Nuclear Purification Nuclear purity is achieved with the help of the treatment of commercial concentrates of uranium ("yellow cake"). ...

1988-06-03

410

India's tryst with modern astronomy

... taker', Adaptive Behavior. In submission. Behavioral Disorders: Diagnostic Criteria for Re- Breazeal (Ferrell), C. (1998), A Motivational System for ...

2011-05-13

411

Improved Usability of Locomotion Devices Using Human ...

Sumedh Anathpindika surveys astronomy in India and finds a lively and developing community as well as great public interest.

2011-01-01

412

Imaging Automation and Volume Tomographic Visualization at Texas Neutron Imaging Facility

... increasing photorealism. Furthermore, developments in audio technology continue to increase the spatial awareness of users in VEs. ...

2009-03-01

413

IT development and application practices in Daya Bay Nuclear Power Station

A thermal neutron imaging facility for real-time neutron radiography and computed tomography has been developed at the University of Texas reactor. The facility produced good-quality radiographs and two-dimensional tomograms. Further developments have been recently accomplished. A computer software has been developed to automate and expedite the data acquisition and reconstruction processes. Volume tomographic visualization using Interactive Data Language (IDL) software has been demonstrated and will be further developed. Volume tomography provides the additional flexibility of producing slices of the object using software and thus avoids redoing the measurements.

1999-11-14

414

Human Systems Center Products and Progress.

2002 p. 139 China Sun Haiying Ye Zhiqiang Bu Jianhua Guangdong Nuclear

415

How the Energy and Water Development Appropriations Act of 1993 has impacted the constitutional dynamics of federal wetlands delineation and regulation

... Page 43. Integrated Audio Technology Demonstrator The Integrated Audio Technology Dem- development for this application is successful. ...

1993-10-01

416

HARPHRQ. A Geochemical Speciation Program Based on PHREEQE

A reliable source of specific criteria for recognizing a wetland, as defined for regulatory purposes would be valuable. In 1987 the Army Corps of Engineers developed a technical manual for identifying wetlands (1987 Wetlands Manual). An interagency manual (1989 Wetlands Manual) was later developed. This manual has been used to identify wetlands according to three evidentiary factors: vegetation, hydrology, and soil. This paper addresses the development of criteria to delineate wetlands, and describes some of the logic used by federal courts to uphold the limited constitutional use of the 1989 Wetlands Manual.

1995-12-31

417

Growth, Characterization and Device Development in ...

HARPHRQ is a geochemical speciation program developed at Harwell and based on the U.S. Geological Survey code Phreeqe.

1992-02-18

418

Geometric and topological methods for quantum field theory

... eV. In some instances the spontaneous radiation from a free electron laser system was employed to obtain images. The ...

1998-03-01

419

Fungal laccases: production, function, and applications in food processing.

An introduction to recent developments in several active topics at the interface between algebra, geometry, topology and quantum field theory

2010-01-01

420

Fibrillation of Commercial Acrylic Fiber for Use in Combustible Cartridge Cases.

Laccases are increasingly being used in food industry for production of cost-effective and healthy foods. To sustain this trend widespread availability of laccase and efficient production systems have to be developed. The present paper delineate the recent developments that have taken place in understanding the role of laccase action, efforts in overexpression of laccase in heterologous systems, and various cultivation techniques that have been developed to efficiently produce laccase at the industrial scale. The role of laccase in different food industries, particularly the recent developments in laccase application for food processing, is discussed. PMID:21048859

2010-09-21

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

421

FURTHER DEVELOPMENT OF THE AN/DMQ-9 ...

A production method was developed to fibrillate commercial acrylic fiber suitable for the manufacture of combustible cartridge cases.

1983-01-01

422

Energy Engineering Analysis Program (EEAP), Cornhusker ...

... is disengaged from the spent rocket motor by a ... of the outbound and incoming modu- ... meteorological sensor and reference resistor is accomplished ...

1965-06-01

423

Enabling Lightwave Electronics with Nanotechnology ...

... is to develop a systematic program of energy consumption reductions in compliance with the stated goals of the Army Facilities Energy Plan (AFEP ...

1984-03-01

424

Effect of low dose of radioactive iodine on mammalian brain development

... Acousto-optic programmable dispersive filters (AOPDF) have been developed for optical signal processing, polarization switching in lasers, and ...

2011-03-29

425

E-13662-1 Layout - GLTRS - NASA

Russian 1997 p. 266-267 Russian Federation Ushakova, GA

426

Discussion on closed nuclear fuel cycle strategy in China

Group for Aerospace Research and Development (AGARD) symposium and continue to ...... of vertical structures and flow separation within the tip, platform, ...

427

Development of the EE-1 small community solar thermal power system

According to China's 'Medium- and Long-term Nuclear Power Development Program (2005-2020)', nuclear energy development in China will take the technical line of closed nuclear fuel cycle. This paper discusses the significance of closed nuclear fuel cycle, and briefly introduces development trends in the world. This article also discusses the opportunity to construct spent fuel reprocessing plant; equilibrium of plutonium production and consumption; adaptability and economics to use MOX fuel in the thermal neutron reactor. Some suggestions are put forward to the overall development of nuclear energy in China. (authors)

2008-05-01

428

Development of equipment for irradiated nuclear fuel reprocessing plant

The development status of the EE-1 Small Community Solar Thermal Power Experiment (SCSE Program) is presented. Current activities on the Phase II single module development effort are presented, together with plans for a Phase III 1 MW/sub e/ demonstration plant. A description of the various subsystems and components is given with a brief review of their development background. Latest performance figures are given for a 1 MW/sub e/ plant, based on 56 power modules, each consisting of a 12m parabolic dish concentrator, a cavity receiver, an organic Rankine power conversion subsystem and a ground-mounted solid-state rectifier.

1981-01-01

429

Development of an efficient, low-NOx domestic gas range cooktop. Phase 3. Final report, January 1986-December 1988. Technical report

2002 p. 9-10, 83-84 Russian Federation Glagolenko, Yu.V. Dzekun, EG

430

Development of an Agroforestry Sequestration Project in Khammam District of India | International Energy Studies

The objective of the program was to develop a domestic cooktop with low-NOx emissions and high efficiency. During the first two phases of the program, three design concepts were developed, and two versions of developmental prototypes using the IR-Jet approach were fabricated and tested. The third phase was initiated to address the design issues of a simmer setting, air/gas metering, and jet plate durability and to develop prototypes for interested manufacturers.

1989-10-01

431

Development of a solvent extraction process for cesium removal from SRS tank waste

...Development of an Agroforestry Sequestration Project in Khammam District of India | International Energy Studies International Energy Studies News | Researchers | Publications ...Technologies Division Industrial Innovations Industrial Energy Analysis Copyright &1692006 Disclaimer Development of an Agroforestry Sequestration Project in Khammam District of India Authors:P. Sudha; V.... Vasistha 2006-10-10 0 Development of an Agroforestry Sequestration Project in Khammam District of India P. Sudha, V. Ramprasad, M.D.V. Nagendra,...

432

Development of a CFD Program for Cold Gas Flow Analysis in a High Voltage Circuit Breaker Using CFD-CAD Integration

An alkaline-side solvent extraction process was developed for cesium removal from Savannah River Site (SRS) tank waste. The process was invented at Oak Ridge National Laboratory and developed and tested at Argonne National Laboratory using singlestage and multistage tests in a laboratory-scale centrifugal contactor. The dispersion number, hydraulic performance, stage efficiency, and general operability of the process flowsheet were determined. Based on these tests, further solvent development work was done. The final solvent formulation appears to be an excellent candidate for removing cesium from SRS tank waste.

2001-06-30

433

Development of Jelly-Type Simulating Polymer Based Human Tissue for Research on Hyperthermia by High Frequency Magnetic Field

Full Text Available

2002-05-01

434

Development of Decision Making Model for Optimal Location of Washland based on Flood Control Effect estimated by Hydrologic Approach

Full Text Available

2006-11-01

435

Development and Calibration of Two and Four Wire Water ...

Full Text Available

2008-07-01

436

Development Document for Proposed Effluent Limitations Guidelines, New Source Performance Standards, and Pretreatment Standards for the Iron and Steel Manufacturing Point Source Category.

... measurement. Power spectral density measurements are made by the dynamic signal analyzer for each channel. A cross power ...

1992-12-01

437

Development Document for Proposed Effluent Limitations Guidelines and New Source Performance Standards for the Organic Chemicals and Plastics and Synthetic Fibers Industry.

No abstract available.

1980-01-01

438

No abstract available.

1983-01-01

439

Development - NASA

Design, Fabrication, Test, and Evaluation of Spiral Bevel ...

12], the Predictive Capability Maturity Model (PCMM) [ref. 13], the Uncertainty Structure scale [ref. 11], and the Simulation Readiness Level (SRL) scale ...

440

DEVELOPMENT OF KSC PROGRAM FOR INVESTIGATING AND - NASA Technical ...

... Development Tapered Roller Bearing Program . . . 11 ... 98 61 Tapered Roller Bearing Component t Identification..... 104 ...

1973-06-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

441

DEVELOPMENT OF A TUNED DAMPER TO REDUCE ...

Aluminum electrolytic capacitors, with 1043 failures, are a good example. Also, categorization by size and voltage reveals such frequencies of occurrence as ...

442

Considerations in the Design and Development of a Human ...

... Since power spectral density measurements are the result of a statisti- cal sampling process, as are the probability measurements, we now ...

1967-09-01

443

Concerning a Comprehensive Nuclear Test Ban

... appropriate. At press time, the laws governing the use of digital audio technology and the technology itself are rapidly changing. ...

1990-09-20

444

Combustible Cartridge Cases, an Account of the Current ...

... US Congress, Joint Committee on Atomic Energy, Development, Use, and Control ofNuclear Energy for the Common Defense and Security and for ...

2011-05-14

445

Chiral dynamics of few-nucleon systems

... ADA185428. Title : Combustible Cartridge Cases, an Account of the Current Technology and Proposals for Future Development. ...

1986-10-01

446

Carbon Smackdown: Cookstoves for the developing world

I discuss some recent developments in chiral effective field theory for few-nucleon systems.

2008-06-01

447

ScienceCinema

...contribution to global warming ...states i think impact of global warming ? and ...contributor to global warming ...

448

COMMUNICATION MEDIA AND EDUCATIONAL TECHNOLOGY AN - NASA Technical ...

COMBUSTIBLE AMMUNITION FOR SMALL ARMS. 1. ...

adaptations of analog audio technology Recent developments in tape cassette technolocy have made Itpossible to provide up to ...

449

Asperger Syndrome - What it Feels Like (3)

... Research on development of combustible cartridge cases for small arms was conducted in Germany during World War II. ...

1960-05-01

450

Brain Basics

Medline Plus

... Such disorders include depression , anxiety disorders , bipolar disorder , attention deficit hyperactivity disorder (ADHD) , and many others. Some people who develop ...

451

Applied nuclear science research and development. Semiannual progress report, October 1, 1983-May 31, 1984

Jake, who has been diagnosed with Asperger syndrome, explains that he has developed a number of ritualistic habits.

2009-04-14

452

Anticipatory nausea and vomiting

Separate entries are individually indexed.

1985-01-01

453

British Library Electronic Table of Contents (United Kingdom)

A commonly reported consequence of post-treatment nausea or vomiting is the development of anticipatory nausea and vomiting (ANV). In most published work, nausea is reported to occur before chemotherapy drugs are administered by approximately 20% of patients at any one chemotherapy cycle and by 25?30% of patients by their fourth chemotherapy cycle. Most studies in adult patients strongly support the view that the development of ANV involves elements of classical conditioning. The best method to avoid development of ANV is to adequately prevent both vomiting and nausea from the first exposure to chemotherapy. If anticipatory side effects develop, behavioral treatment techniques, such as systematic desensitization, have been shown effective. Benzodiazepines used in combination with behaviora...

2011-01-01

454

An object oriented software bus

An application of possibilistic programming to the fuzzy location?allocation problems

This paper describes a new approach to development of software for highly integrated software-hardware systems such as used for data acquisition and control. This approach, called the Object Oriented Software Bus (OSB), is a way to develop software according to a common specification similar to the way interface hardware has been developed since the advent of bus structures for minicomputers and microcomputers. Key concept of the OSB is extension of the common use of objects to support user interface and data analysis functions to the development of software objects that directly correspond to real- world hardware interfaces and modules.

1995-12-31

455

British Library Electronic Table of Contents (United Kingdom)

This paper considers location?allocation problem in the real uncertain world and develops a possibilistic non-linear programming model to deal with this problem. Fuzzy decision making in fuzzy environment concept is used to determine possibility distribution of location and allocation variables. To solve this model, a novel approach based on genetic algorithm structure is developed. As the proposed model includes both deterministic (location) and uncertain (allocation) parameters, the developed solution algorithm uses a hybrid chromosome structure. Also, to cover continuous nature of the problem and prevent GA from early convergence, a new crossover operator is introduced. Finally, performance of the developed algorithm is evaluated by an example.

2011-01-01

456

Alaska: a guide to geothermal energy development

Advanced Thermal Management for Military Application

A brief overview is given of the geological characteristics of each region of the state as they relate to potential geothermal development. Those exploration methods which can lead to the siting of a deep exploration well are described. Requirements and techniques needed for drilling deeper higher temperature exploration and production wells are presented. Electrical generation, direct utilization, and indirect utilization are reviewed. Economic factors of direct use projects are presented. A general guide to the regulatory framework affecting geothermal energy development is provided. The general steps necessary to gain access to explore, develop, distribute, and use geothermal resources are outlined. (MHR)

1980-06-01

457

Absorption-Electrochemical Surface Decontamination

... management. 5.3 Decreased Emissions Changes in engine emission regulations are driving engine technology development. A ...

2004-12-01

458

A study to develop the domestic functional requirements of the specific safety systems of CANDU

Development of a Comprehensive Decontamination Database and an Absorption-Electrochemical Metal Surface Decontamination Technique Combining Chemical and Electrochemical Process

459

A study to develop the domestic functional requirements of the specific safety systems of CANDU

The present research has been made to develop and review critically the functional requirements of the specific safety systems of CANDU such as SDS-1, SDS2, ECCS, and containment. Based on R documents for this, a systematic study was made to develop the domestic regulation statements. Also, the conventional laws are carefully reviewed to see the compatibility to CANDU. Also, the safety assessment method for CANDU was studied by reviewing C documents and recommendation of IAEA. Through the present works, the vague policy in the CANDU safety regulation is cleaning up in a systematic form and a new frame to measure the objective risk of nuclear power plants was developed.

2003-03-15

460

A Structural Approach to the Photonic Processor

The present research has been made to develop and review critically the functional requirements of the specific safety systems of CANDU such as SOS-1, SOS-2, ECCS and containment. Based on R documents for this, a systematic study was made to develop the domestic regulation statements. Also, the conventional laws are carefully reviewed to see the compatibility to CANDU. Also, the safety assessment method for CANDU was studied by reviewing C documents and recommendation of IAEA. Through the present works, the vague policy in the CANDU safety regulation is cleaning up in a systematic form and a new frame to measure the objective risk of nuclear power plants was developed.

2001-03-15

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

461

... UUV Unmanned Underwater Vehicle ... 26- VISION-ASSISTED ROBOT TASKS ... Specifically, the development of autonomous robots depends on ...

2011-05-14

462

27 - NASA

Transforming growth factor-? signaling mediates hypoxia-induced pulmonary arterial remodeling and inhibition of alveolar development in newborn mouse lung

02.10.10 - NASA and Texas Instruments are using the theme of human space exploration to develop digital libraries of math and science problems for high ...

463

The results of investigations in connection with development of methods for integrated optimization of fast reactors parameters

Hypoxia causes abnormal neonatal pulmonary artery remodeling (PAR) and inhibition of alveolar development (IAD). Transforming growth factor (TGF)-β is an important regulator of lung development...Full Text Available

2008-07-01

464

Synfuels: how much can they help. [Chevron activities

The results for development of methods and computer programs for integrated optimization of parameters of perspective fast reactors are given. The possibilities of the program for the reactor campaign calculation are analysed. This program is based on utilisation of the Bubnov-Galerkin method and Wigner disturbance theory. The possibility of application of approximation methods for the optimization researches is discussed. The results of development of the programs for complex reactor computations with account of control rods system and change of physical parameters in the reactor campaign are discussed. (author).

1974-07-01

465

Progress posted in coal liquefaction technology

A series of questions and answers addresses issues related to developing synthetic fuels, including the potential supplies, regulatory road blocks, and development incentives to promote the role of the private sector. Chevron's efforts in the area of synfuels are aimed at shale oil tar sands and coal conversion. The status of these research and development projects and the projected recoverable reserves from each are summarized. (DCK)

466

Producing Open Source Software How to Run a Successful Free Software Project

This article discusses the latest developments made in the field of technology used for coal liquefaction. Some new areas of development in research and development work are described. Particular consideration is given to low-severity processing. This has two advantages, mostly low-molecular-weight fragments are produced and the extracts are low in heteroatoms. A detailed description of low-severity processing is given. The refining of the liquids produced from coal is also covered.

1986-04-28

467

Perspectives on energy storage wheels for space station application

This comprehensive guide offers several tried and true steps to help you successfully manage the complex process of developing free software. Topics include project management, developer motivation, technical infrastructure to support collaboration, and project promotion. Producing Open Source Software is ideal for developers starting their own free software projects, or people who simply want to participate in the process.

2009-01-01

468

Mitigating socio-economic impacts of energy development

Several of the issues of the workshop are addressed from the perspective of a potential Space Station developer and energy wheel user. Systems considerations are emphasized rather than component technology. The potential of energy storage wheel (ESW) concept is discussed. The current status of the technology base is described. Justification for advanced technology development is also discussed. The study concludes that energy storage in wheels is an attractive concept for immediate technology development and future Space Station application.

1984-11-01

469

IDEAS: Journal of International Trade & Economic Development, Taylor and Francis Journals

This study provides information on energy resource development and the efforts of State and local communities in the Rocky Mountain, Appalachian, and coastal regions to deal with the related social and economic impacts. It also provides information on the range of options and resources generally available to States and local communities from local, State, industry, and Federal sources to plan for and mitigate the adverse effects of energy development. Onsite visits and interviews with State, local, and Federal officials and private industry involved in mitigating socioeconomic impacts were made.

1982-03-02

470

Guidebook to financing CDM projects

... (restricted)] 101-127 On the transmission of exchange rate fluctuations to the macroeconomy: Contrasting evidence for developing and developed countries by Magda Kandil [Downloadable! (restricted)] 2005, Volume 14, Issue 4 377-405 Predicting the poverty impacts of trade reform by Thomas Hertel & Jeffrey Reimer [Downloadable! (restricted)] 407-435 Sustaining imperfectly credible trade liberalization: Do the rate of tariff reduction ...

471

Final report - Sundyne Company

One of the challenges facing Clean Development Mechanism (CDM) projects today is their limited ability to secure financing for the underlying greenhouse gas emission reduction activities, particularly in the least developed countries. Among the key reasons for this is the fact that most financial intermediaries in the CDM host countries have limited or no knowledge of the CDM Modalities and Procedures. Moreover, approaches, tools and skills for CDM project appraisal are lacking or are asymmetrical to the skills in comparable institutions in developed countries. Consequently, developing country financial institutions are unable to properly evaluate the risks and rewards associated with investing or lending to developers undertaking CDM projects, and therefore have, by-and-large, refrained from financing these projects. In addition, some potential project proponents lack experience in ...

2007-07-01

472

Experience from the development of Point Lepreau's training program for technical support staff

Solar cookers offer a viable alternative to conventional cooking methods in many areas, and can be an effective tool in the fight against the deforestation and desertification that plague many developing countries. However, there have been numerous obstacles to the successful dissemination of solar cookers in the past. The purpose of this paper is to identify opportunities, review constraints and develop a marketing strategy to disseminate the Sundyne Solar Cooker (SSC) in developing countries.

1994-09-27

473

Evaluation of the SYNTHOIL process. Volume II. Status of development. [47 refs

The Training Department at the Point Lepreau GS has been developing and improving its training for technical support staff. A generic set of objectives are being used as the basis for a systematic approach to training. The program covers general and job specific knowledge and skills using a mix of classroom instruction, mentoring and continuing training seminars. This paper describes experience, success and the challenges in the development, delivery and evaluation of the training program. (author)

2007-06-03

474

Energy for Lebanon of tomorrow: paradigm of sustainable development and environment

The Synthoil process for producing heavy desulfurized fuel oil from coal has been under development at Pittsburgh Energy Research Center since 1969. The status of development and technical feasibility of the process are reviewed. This is part of an engineering and economic evaluation based on the conceptual design of a 100,000-bbl/day commercial Synthoil facility. Experimental data are discussed with regard to their adequacy for the formulation of a basis for the process design of such a facility. Potential engineering and equipment problems are analyzed.

1977-06-01

475

Effect of lifetime nutrition on ruminant carcass and meat quality

An overview of the present status of energy sector in Lebanon and requirements of its future development is presented. The study is based on an economic analysis of needs and energy consumption among the population and on a comparison with other developing countries. Tables and graphs on energy distribution, needs and demands per habitant and national income are included. 3 figs. 3 tabs.

476

Environmental Research Database

DescriptionThis application is a request for Bridge Link funds to support studies in order to develop a full proposal under the Link Sustainable Livestock Scheme in collaboration with Dr Nigel Scollan of IGER. The hypothesis being examined is that the poor performance of some ruminants is due to poor nutrition at strategic time points during the animal's development. The initial hypothesis will be tested in sheep and the results from this will be used to develop the full proposal. Excessive fat in ruminan [continued...

2006-01-31

477

Effect of hydrogen on structure and properties of #beta#-titanium alloy VT-15 during bending tests in various media

Dounreay: an alternative development

It is shown that bending tests on microsamples can be used to study the conditions in which hydrogen brittleness develops. In such tests hydrogen brittleness develops in the VTI5 alloy within the temperature range +5 to -20"0C. The tendency of VTI5 to develop hydrogen brittleness is enhanced with bending in salt water. (author).

478

Development of neutral-beam injectors. Report on the third workshop, Gatlinburg, Tennessee, United States of America 19-23 October 1981

With the Government decision to phase out the Fast Reactor at Dounreay there is a need to find alternative employment in the area. Traditionally Caithness is an area of farming, fishing and tourism which could be damaged if Dounreay were to be made a nuclear waste repository. The suggestion is that Dounreay should become a centre for research, development and subsequent manufacture of renewable energy sources and devices to harness renewable energy. The Scottish coastline has potential for wind and wave power developments and this could lead to a whole industry in the future. (UK).

1991-01-01

479

Development of internal dose estimation software on radiation protection

This paper reports on the third workshop on the development of neutral-beam injectors held from 19-23 October 1981 at Gatlinburg, Tennessee, USA. The programme of the workshop was devoted to the development of positive-ion-based neutral injectors, although several techniques for producing negative ion beams were also discussed.

1982-03-01

480

Development of a high-output dual-fuel engine

Objective: To develop a computerized method of internal dose estimation on radiation protection. Methods: Based on MIRD mathematic model of the organs and by means of the programming language of MS Visual Basic 6.0, a computer program of dose estimation in internal radiation was developed for radiation protection. Results: The computerized method of dose estimation for internal radiation was completed. Conclusions: This computerized method is very convenient for internal radiation dose estimation of several aspects. It can also be used in radiation accident. (authors)

2008-10-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

481

Development of Bulk Nanocrystalline Cemented Tungsten Carbide for Industrial Applicaitons

This paper presents the results of a new dual-fuel engine development program. The engine is the largest commercially available in terms of power output (650 hp/cyl) and features very low emissions (1 g/hp-hr NO[sub x]) and excellent fuel consumption (43 percent thermal efficiency). A two-cylinder turbocharged prototype was designed and built for the initial development. Results from testing on 18-cylinder production versions are also reported.

1993-10-01

482

Development and application of a gamma scanning system for LLW and MLW packages

This report contains detailed information of the research program entitled "Development of Bulk Nanocrystalline Cemented Tungsten Carbide Materials for Industrial Applications". The report include the processes that were developed for producing nanosized WC/Co composite powders, and an ultrahigh pressure rapid hot consolidation process for sintering of nanosized powders. The mechanical properties of consolidated materials using the nanosized powders are also reported.

2009-03-10

483

DEVELOPMENT OF CONTINUOUS SOLVENT EXTRACTION PROCESSES FOR COAL DERIVED CARBON PRODUCTS

The report describes the studies carried out to design a non-destructive system for the radiological characterization of packages containing LLW and MLW. This technique is applied for quantitative and qualitative gamma emitters determination in packages with homogeneous and heterogeneous matrices as well as the development of a maximum activity points location system. Development involves also the automatization for its industrial use.

1993-09-05

484

DEVELOPMENT AND PILOT PLANT EVALUATION OF SILICA-ENHANCED LIME SORBENTS FOR DRY FLUE GAS DESULFURIZATION (JOURNAL VERSION)

The purpose of this DOE-funded effort is to develop continuous processes for solvent extraction of coal for the production of carbon products. These carbon products include materials used in metals smelting, especially in the aluminum and steel industries, as well as porous carbon structural material referred to as ''carbon foam'' and carbon fibers. During this reporting period, efforts have focused on the facility modifications for continuous hydrotreating, as well as developing improved protocols for producing synthetic pitches.

2005-08-11

485

Computer simulation of martensitic transformations

The paper discusses recent work on lime enhancement and testing at the bench-scale, followed by evaluation of the more promising sorbents in a pilot plant to develop low cost, retrofittable flue gas cleaning technology specifically the development of highly reactive sorbents. Con...

486

Coal liquefaction process streams characterization and evaluation

The characteristics of martensitic transformations in solids are largely determined by the elastic strain that develops as martensite particles grow and interact. To study the development of microstructure, a finite-element computer simulation model was constructed to mimic the transformation process. The transformation is athermal and simulated at each incremental step by transforming the cell which maximizes the decrease in the free energy. To determine the free energy change, the elastic energy developed during martensite growth is calculated from the theory of linear elasticity for elastically homogeneous media, and updated as the transformation proceeds.

1993-11-01

487

Coal liquefaction process streams characterization and evaluation

Consol R D is conducting a three-year program to characterize process and product streams from direct coal liquefaction process development projects. The program objectives are two-fold: (1) to obtain and provide appropriate samples of coal liquids for the evaluation of analytical methodology, and (2) to support ongoing DOE-sponsored coal liquefaction process development efforts. The two broad objectives have considerable overlap and together serve to provide a bridge between process development and analytical chemistry.

1991-11-01

488

Coal demonstration plants. Quarterly report, October--December 1976

Consol R D is conducting a three-year program to characterize process and product streams from direct coal liquefaction process development projects. The program objectives are two-field: (1) to obtain and provide appropriate samples of coal liquids for the evaluation of analytical methodology, and (2) to support ongoing DOE-sponsored coal liquefaction process development efforts. The two broad objectives have considerable overlap and together serve to provide a bridge between process development and analytical chemistry.

1991-11-01

489

Coal demonstration plants. Quarterly report, July--September 1976

In addition to an executive summary and glossary, the following sections are included: Clean Boiler Fuel Demonstration Plant; Development of Coal Feeders for Coal Gasification Operations; Development of a Continuous Dry Coal Screw Feeder; Coal Feeder Development Program; Engineering and Technical Support; Technical Assistance Services; and Conceptual Design for an Advanced Coal Liquefaction Commercial Plant. (EJH)

1976-01-01

490

Chemicals from coal: New processes

In addition to an executive summary and glossary, the following sections are included: Clean Boiler Fuel Demonstration Plant; Development of Coal Feeders for Coal Gasification Operations; Development of a Continuous Dry Coal Screw Feeder; Coal Feeder Development Program; Engineering and Technical Support; and Technical Assistance Services. (EJH)

1976-01-01

491

Boron in nuclear medicine: New synthetic approaches to PET and SPECT. Final report, May 1, 1986--April 30, 1996

This book deals specifically with the development of new processes of converting coal into useful chemical feedstocks. The major topic in this volume is the generation of syngas and its catalytic conversion to chemicals via the Fischer-Tropsch synthesis. Describes processes involved in conversion, recent catalytic developments, and the commercially important Sasol process. Also includes chapters on the carbide process and potential of future developments in the field.

1987-01-01

492

Research is described in the development of organometallic reagents in which the boron was attached to a nonreactive organic or inorganic matrix such as polystyrene, silica, or alumina. We developed the synthesis of oxygen-15 labelled butanol, which has been found to be a valuable blood flow agent in humans. We have also developed a series of polymeric borane derivatives which were used to prepare nitrogen-13 labelled amines.

1997-08-01

493

Annual report 1995

The development of fast breeder reactors

REXFOR is a development corporation involved in the creation of sustainable economic development for Quebec`s forest sector. Through partnerships, it intervenes in the development and processing of forest resources. This annual report provides an overview of industrial, sylvicultural and forest activities for the current year. A financial review of the current year is given along with a retrospective of the last five years. Financial statements are included.

1995-12-31

494

Technical development of equipment for rural electrification resulting from the lessons drawn from the Polynesian programs of the eighties

Modern civilisation is based on substantial utilisation of energy. Rapid industrial development and improvement of living standards in India require energy planners to adequately forecast the energy demand and take appropriate measures in advance. However, the development and establishment of new technology is a slow process, sometimes extending over decades. Hence, energy options based on new technologies need to be planned for much in advance making allowance for uncertainties and delays. Fast Breeder Reactor (FBR) technology is an advanced energy option promising abundant and economic supply of power. Research and development work on FBRs has been conducted at the Indira Gandhi Centre of Atomic Research (IGC) since 1971. The international trends in FBR development are highlighted in this discussion and an overview of some of the research activities at IGC is presented. (author). 8 refs., 7 tab s.

495

Morphological and histological study of larval development of the Senegal sole Solea senegalensis: an integrative study

The information gathered as operating manager when implementing the first photovoltaic rural electrification and technology transfer program carried out to date in the world in French Polynesia from 1978 to 1990 are detailed. The technical developments of equipment and the work in progress at the GENEC Cadarache within French, European or IEA programs in order to improve some components or appliances and make up for certain deficiencies are presented. This involves accelerated aging tests, Standardization work, development of high efficiency equipment. Non technical barriers are often emphasized. Technical barriers also exists. Considerable work in many domains of small PV systems remains to be done so as to combine all the conditions required to implement successful large programs in developed as well as in developing countries.

1994-12-31

496

British Library Electronic Table of Contents (United Kingdom)

This study provides a comprehensive description of the main morphological and histological events that take place during larval and post-larval development of Senegal sole Solea senegalensis in order to establish a reference for its normal developmental organogenesis. Five stages have been described. Before gill development at the onset of metamorphosis (eye migration process, stage 4c), the skin was the main site of gas and ion exchange, whereas during stages 3 and 4, the skin begins differentiating into the definitive juvenile structure. The timing of development of the endocrine system depends on each organ, the endocrine pancreas and thyroid gland being the first to differentiate (stages 2 and 3, respectively), followed by the interrenal tissue and stannius corpuscles that develop at m...

2011-01-01

497

Impact of ocean pollution

How Design-based Research, Action Research and Interaction Design Contributes to the Development of Designs for Learning

Man's wastes are polluting the oceans from various sources and delivered by various routes. The result has been the loss of habitat and the irreversible altering of marine ecosystems. Development in the coastal zones and offshore activities that disrupt biologically sensitive areas have led to international negotiations to regulate these impacts and develop a law of the sea. Basic to international cooperation, however, is the need to develop answers to questions about the ecological consequences of development programs and the carrying capacity of the oceans. Current information does not demonstrate long-term global impacts, making it difficult to detect and predict incremental changes and causal relationships. Society needs to determine how much environmental damage it will accept and then to develop appropriate technology, such as biomonitoring. Society also needs to ...

1981-03-01

498

Energy R and D. Geothermal energy and underground reservoirs; R et D energie. Geothermie et reservoirs souterrains

This article explores how action research, design based research and interaction design can be combined and used in the development of educational robotic tools. Our case study is the development of Number Blocks and it combines physical interaction, learning, and immediate feedback. Number Blocks supports the children's understanding of place value in the sense that it allows them to experiment with creating large numbers. The development was done in collaboration with a class of 7-8 year old children and their mathematics teacher. The article argues that elements from different research methods allowed a structured approach to projects that combines educational research and innovation of new learning technologies. Key elements of this approach is acknowledging the users input, developing a theoretical pre-analysis and using an iterative approach.

2011-01-01

499

Development of engineering technology basis for pyrometallurgical reprocessing: development of transport technology and pyro-process equipments

Geothermal energy appears as a viable economic alternative among the different renewable energy sources. The French bureau of geological and mining researches (BRGM) is involved in several research and development programs in the domain of geothermal energy and underground reservoirs. This document presents the content of 5 programs: the deep hot dry rock system of Soultz-sous-Forets (construction and testing of the scientific pilot, modeling of the reservoir structure), the development of low and high enthalpy geothermal energy in the French West Indies, the comparison of the geothermal development success of Bouillante (Guadeloupe, French West Indies) with the check of the geothermal development of Nyssiros (Greece) and Pantelleria (Italy), the development of the high enthalpy geothermal potentialities of Reunion Island, and the underground storage of CO{sub 2} emissions in ...

2001-07-01

500