zealand birth cohort: Topics by WorldWideScience.org

Incidence and Determinants of Birth Defects and Enzyme Deficiencies among Live Births in Oman

A cohort of singleton black human females exposed to diagnostic x-ray in utero and controls matched by parity, hospital of birth and birthdate have been followed to ages 25 to 30 years in Baltimore, Maryland. The search for possible effects of prenatal irradiation has focused on health, growth, development, and reproductive experience of exposed and control women. This paper reports findings related to reproductive experience. From an original data set of 1458 matched exposed-control pairs of women, questionnaire responses were received from 1109 exposed and 1124 control women including 852 each from pairs in which both the exposed and control woman responded. After careful search for alternative explanations of the findings, the authors concluded that females exposed in utero to low doses of x-ray (probably 1 to 5 rads) had significant increases in their rates of early onset of menses, births at age 15 years or less, ...

1981-09-01

Low Birth Weight, Very Low Birth Weight Rates and Gestational Age-Specific Birth Weight Distribution of Korean Newborn Infants

ObjectivesIn 2003, the Omani Ministry of Health Child Health Care Program initiated a national Birth Defects (BD) Register. This paper reviews the magnitude and risk factors of birth...Full Text Available

2010-04-01

An Ecological Risk Model for Early Childhood Anxiety: The Importance of Early Child Symptoms and Temperament

To obtain the low birth weight (LBW) rate, the very low birth weight (VLBW) rate, and gestational age (GA)-specific birth weight distribution based on a large population in Korea, we collected and analyzed...Full Text Available

2005-04-01

Notes on New Zealand Floristic Botany, including Descriptions of New Species, Etc. (No. 6).

Childhood anxiety is impairing and associated with later emotional disorders. Studying risk factors for child anxiety may allow earlier identification of at-risk children for prevention efforts. This study applied an ecological risk model to address how early childhood anxiety symptoms, child temperament, maternal anxiety and depression symptoms, violence exposure, and sociodemographic risk factors predict school-aged anxiety symptoms. This longitudinal, prospective study was conducted in a representative birth cohort (n = 1109). Structural equation modeling was used to examine hypothesized associations between risk factors measured in toddlerhood/preschool (age = 3.0 years) and anxiety symptoms measured in kindergarten (age = 6.0 years) and second grade (age = 8.0 years). Early child risk factors (anxiety symptoms and temperament) emerged as the most robust predictor for both parent-and child-reported anxiety outcomes and mediated the effects ...

2011-05-01

Transactions and Proceedings of the Royal Society of New Zealand 1868-1961

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1936-01-01

Hudson Lecture for 1958 Darwinism in New Zealand: Some Examples, Influences and Developments

Transactions and Proceedings of the Royal Society of New Zealand 1868-1961

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1959-01-01

Distribution of the Mosses Indigenous to New Zealand (Supplement No. 1)

Transactions and Proceedings of the Royal Society of New Zealand 1868-1961

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1948-01-01

A Spatial Analysis of the Relationship Between Mangrove (Avicennia marinavar.australasica) Physiognomy and Sediment Accretion in the Hauraki Plains, New Zealand

Causes of Fever in the ICU - A Prospective, Cohort Study

Not Available

1996-02-01

KoreaScience (Korea)

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2008-06-01

Reproductive factors and exogenous hormone use in relation to risk of glioma and meningioma in a large European cohort study

The risk of ano-genital malignancies in dialysis and transplant patients.

BACKGROUND: The aetiologies of glioma and meningioma tumors are largely unknown. Although reproductive hormones are thought to influence the risk of these tumors, epidemiologic data are not supportive of this hypothesis; however, few cohort studies have published on this topic. We examined the relation between reproductive factors and risk of glioma and meningioma among women in the European Prospective Investigation into Cancer and Nutrition (EPIC).METHODS: After a mean of 8.4 years of follow-up, 193 glioma and 194 meningioma were identified among 276,212 women. Information on reproductive factors and hormone use was collected at baseline. Cox proportional hazard regression was used to determine hazard ratios (HR) and 95% confidence intervals (CI). RESULTS: No associations were observed between glioma or meningioma risk and reproductive factors, including age at menarche, parity, age at first birth, menopausal status, and age at menopause. A ...

2010-01-01

Progesterone for the prevention of preterm birth: indications, when to initiate, efficacy and safety

The incidence of anogenital malignancies is greatly increased in patients who have received a renal transplant, but this has not been well studied in patients receiving maintenance dialysis. Our aim was to assess the incidence of these malignancies in patients on dialysis and compare these to transplanted patients. The age standardized incidence ratio (SIR) for anogenital malignancies was calculated by comparing the observed number of malignancies to the expected number. The expected number was calculated by multiplying the age specific incidence rates for each malignancy by the person years at risk in 5-year age cohorts. Of 15,820 patients in the Australia and New Zealand data base, 8,215 had received a renal transplant. A total of 39,750 person years at risk were contributed by patients who had received a renal transplant, while 29,276 person years at risk were contributed by dialysis patients who had not received a renal transplant. For ...

1994-02-01

Factors affecting birth weight in sheep: maternal environment

Preterm birth is the leading cause of neonatal mortality and morbidity and long-term disability of non-anomalous infants. Previous studies have identified a prior early spontaneous preterm birth as...Full Text Available

2009-01-01

Knowledge of factors affecting variation in birth weight is especially important given the relationship of birth weight to neonatal and adult health. The present study utilises two large contemporary...Full Text Available

2007-01-01

Restructuring Primary Health Care Markets in New Zealand: from Welfare Benefits to Insurance Markets

The fatal and non-fatal injuries related to work in commercial fishermen operating out of New Zealand ports is described. Three data sources were used to provide information on the nature of the injuries...Full Text Available

1990-11-01

Investigation into paediatric bilirubin analyses in Australia and New Zealand.

BackgroundNew Zealand's Primary Health Care Strategy (NZPHCS) was introduced in 2002. Its features are substantial increases in government funding delivered as capitation payments,...Full Text Available

Prevention of Preterm Birth in Triplets: An Evaluation of 17 Alpha-Hydroxyprogesterone Caproate

A small regional survey of direct spectrophotometric methods and a larger Australian and New Zealand survey of paediatric bilirubin analyses are described. The overall performance of both groups was...Full Text Available

1982-01-01

Change in Periodontitis during Pregnancy and Risk of Preterm Birth and Low Birthweight

ObjectiveTo assess whether 17 alpha-hydroxyprogesterone caproate reduces the rate of preterm birth in women carrying triplets.MethodsFull Text Available

2009-02-01

Molecular phylogenetics and molecular dating of the New Zealand Gleicheniaceae

AimDetermine if periodontitis progression during pregnancy is associated with adverse birth outcomes.Materials...Full Text Available

2009-04-01

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Cesarean Section Birth

Medline Plus

CESAREAN SECTION SHAWNEE MISSION MEDICAL CENTER MERRIAM, KANSAS March 13, 2008 00:00:09 ANNOUNCER: Tonight you will experience the miracle of birth during ...

Cesarean Section Birth

Medline Plus

CESAREAN SECTION SHAWNEE MISSION MEDICAL CENTER MERRIAM, KANSAS March 13, 2008 00:00:09 ANNOUNCER: Tonight you will experience the miracle of birth during a live ...

Health impact assessment of waste management facilities in three European countries

... Symonds, G. J. Wilson, and H. Zhu. 1997. Seismic stratigraphy and structural history of the Reinga Basin and ... ...

Sexual intercourse association with asymptomatic bacterial vaginosis and Trichomonas vaginalis treatment in relationship to preterm birth.

BackgroundPolicies on waste disposal in Europe are heterogeneous and rapidly changing, with potential health implications that are largely unknown. We conducted a health impact assessment of landfilling and incineration in three European countries: Italy, Slovakia and England.MethodsA total of 49 (Italy), 2 (Slovakia), and 11 (England) incinerators were operating in 2001 while for landfills the figures were 619, 121 and 232, respectively. The study population consisted of residents living within 3 km of an incinerator and 2 km of a landfill. Excess risk estimates from epidemiological studies were used, combined with air pollution dispersion modelling for particulate matter (PM10) and nitrogen dioxide (NO2). For incinerators, we estimated attributable cancer incidence and years of life lost (YoLL), while for landfills we estimated attributable cases of congenital anomalies and low birth weight infants.ResultsAbout 1,000,000, 16,000, and 1,200,000 subjects lived ...

2011-06-02

Cohort study of adherence to correct hand antisepsis before and after performance of clinical procedures

PMID:12439520

2002-11-01

Greenhouse gas emissions from the international maritime transport of New Zealand's imports and exports

Udgivelsesdato: 2009-Feb

2009-01-01

Universal Cervical Length Screening and Treatment with Vaginal Progesterone to Prevent Preterm Birth: A Decision and Economic Analysis

Greenhouse gas emissions from international maritime transport are exempt from liabilities under the Kyoto Protocol. Research into quantifying these emissions is ongoing, and influences policy proposals to reduce emissions. This paper presents a cargo-based analysis of fuel consumption and greenhouse gas emissions from New Zealand's international maritime transport of goods. Maritime transport moves 99.5% (by mass) of New Zealand's internationally traded products. It is estimated that 73% of visiting vessels' activity can be directly attributed to the movement of goods in and out of New Zealand. A cargo-based methodology was used to estimate that the international maritime transport of New Zealand's imports and exports consumed 2.5 million tonnes (Mt; 2.6 billion litres) of fuel during the year 2007, which generated 7.7 Mt of carbon dioxide (CO_2) emissions. Double-counting of emissions would occur if a ...

2011-03-01

The impact of avoidable mortality on life expectancy at birth in Spain: changes between three periods, from 1987 to 2001

ObjectiveTo estimate which strategy is the most cost-effective for prevention of preterm birth and associated morbidity.Study DesignFull Text Available

2010-06-01

The effect of maternal anthropometric characteristics and social factors on gestational age and birth weight in Sudanese newborn infants

Objective:To evaluate the impact of avoidable mortality on the changes in life expectancy at birth in Spain.Methods:Standard life table techniques...Full Text Available

2008-09-01

Temporal changes in key maternal and fetal factors affecting birth outcomes: A 32-year population-based study in an industrial city

BackgroundIn Africa low birth weight (LBW) (<2500 g), is the strongest determinant of infant morbidity and mortality. The aim of this study was to quantify the effect of...Full Text Available

Oral Health in Women During Preconception and Pregnancy: Implications for Birth Outcomes and Infant Oral Health

BackgroundThe link between maternal factors and birth outcomes is well established. Substantial changes in society and medical care over time have influenced women's reproductive...Full Text Available

Inequities in skilled attendance at birth in Namibia: A decomposition analysis

The mouth is an obvious portal of entry to the body, and oral health reflects and influences general health and well being. Maternal oral health has significant implications for birth outcomes and infant...Full Text Available

2006-09-01

Geographical variation in relationships between parental body size and offspring phenotype at birth

BackgroundThe fifth Millennium Development Goal (MDG5) aims at improving maternal health. Globally, the maternal mortality ratio (MMR) declined from 400 to 260 per 100000 live births...Full Text Available

Genetic aspects of birth defects: new understandings of old problems

BackgroundSize and body proportions at birth are partly determined by maternal body composition, but most studies of mother-baby relationships have only considered...Full Text Available

2006-01-01

DNA methylation and gene expression differences in children conceived in vitro or in vivo

Over the past two decades, combined advances in genetics, developmental biology and biochemistry have transformed the study of human birth defects. This review describes the importance of genome architecture,...Full Text Available

2007-07-01

Congenital woolly hair without P2RY5 mutation

Epidemiological data indicate that children conceived in vitro have a greater relative risk of low birth-weight, major and minor birth defects, and rare disorders involving imprinted...Full Text Available

2009-10-15

Gamma Ray Bursts and the Birth of Black Holes

Congenital woolly hair is a disorder with structural defects of the hair shafts. Curled hairs are noticed at birth or soon after birth and often improve with age. Some cases of woolly hairs are associated...Full Text Available

2009-01-01

The physical and mental health of a large military cohort: baseline functional health status of the Millennium Cohort

Black holes have been predicted since the 1940's from solutions of Einstein's general relativity

2009-01-01

Social Change and Socioeconomic Disparities in Health over the Life Course in China: A Cohort Analysis

Background:The US military is currently involved in large, lengthy, and complex combat operations around the world. Effective military operations require optimal health of deployed...Full Text Available

Smoking and All-Cause Mortality among a Cohort of Urban Transit Operators

This article examines social stratification in individual health trajectories for multiple cohorts in the context of China’s dramatically changing macro-social environment. Using data...Full Text Available

2010-02-01

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Health and function of participants in the Long Life Family Study: A comparison with other cohorts

This study assesses the contribution of smoking to all-cause mortality among a primarily minority cohort of urban transit operators. Survey and medical exam data, obtained from 1,785 workers (61% African...Full Text Available

2008-09-01

Exposure to dioxin and nonneoplastic mortality in the expanded IARC international cohort study of phenoxy herbicide and chlorophenol production workers and sprayers.

Individuals from families recruited for the Long Life Family Study (LLFS) (n= 4559) were examined and compared to individuals from other cohorts to determine whether the recruitment targeting longevity...Full Text Available

Alcohol-folate interactions in women's oral cancer risk: A prospective cohort study

The authors studied noncancer mortality among phenoxyacid herbicide and chlorophenol production workers and sprayers included in an international study comprising 36 cohorts from 12 countries followed...Full Text Available

1998-04-01

A case cohort study of suicide in relation to exposure to electric and magnetic fields among electrical utility workers.

BackgroundThe aim of this cohort study was to quantify the effect of alcohol in the risk of oral cancer in different strata of folate intake, controlling for known...Full Text Available

2010-10-01

Bacterial vaginosis and other asymptomatic vaginal infections in pregnancy.

OBJECTIVES--This case cohort study examines whether there is an association between exposure to electric and magnetic fields and suicide in a population of 21,744 male electrical utility workers from...Full Text Available

1996-01-01

The Value of Procalcitonin and the SAPS II and APACHE III Scores in the Differentiation of Infectious and Non-infectious Fever in the ICU: A Prospective, Cohort Study.

Preterm birth is a common cause of neonatal morbidity and mortality. Many asymptomatic genital infections have been associated with preterm birth, but attempts to determine a causal relationship between specific infections and preterm birth have been disappointing. Treatment trials of specific infections have generally failed to show a positive effect, and in some trials have shown a deleterious effect. Although there is a strong association between the presence of bacterial vaginosis and Trichomonas vaginalis in pregnancy and preterm birth, randomized treatment trials have failed to show a benefit of treatment of these organisms. Treatment of asymptomatic bacterial vaginosis or T. vaginalis to prevent preterm birth is not warranted. PMID:12112946

2001-08-01

KoreaScience (Korea)

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2010-11-01

NIST Global Standards Information Korea, Dem Republic

Biosystematics and Conservation: A Case Study with Two Enigmatic and Uncommon Species of Crassula from New Zealand

Australia Brunei Darussalam Burma Cambodia China Fiji Hong Kong Indonesia Japan Korea, Republic of Korea, Dem Republic Laos Malaysia Mongolia New Zealand Philippines...

2011-10-08

Stability and Change in Family Structure and Maternal Health Trajectories

Background and AimsCrassula hunua and C. ruamahanga have been taxonomically controversial. Here their distinctiveness is assessed so that their taxonomic and conservation...Full Text Available

2008-04-01

Pulmonary Function Screening of Submarine Personnel Prior ...

Recent increases in births to unmarried parents, and the instability surrounding these relationships, have raised concerns about the possible health effects associated with changes in family...Full Text Available

2008-04-01

Periodontal disease and spontaneous preterm birth: a case control study

... as the difference between date of birth and date of ... Final model selections were based on the ... approval by the Naval Submarine Medical Research ...

2007-03-26

Oxidative Stress Disrupts Oligodendrocyte Maturation

BackgroundSeveral studies have suggested an association between periodontal disease and prematurity but this finding has not been consistently observed.MethodsCase...Full Text Available

Maternal Marital Status and Birth Outcomes: A Systematic Review and Meta-Analyses

Periventricular white matter injury (PWMI), is the leading cause of chronic neurologic injury among survivors of preterm birth. The hallmark of PWMI is hypomyelination and a lack of mature,...Full Text Available

2009-11-01

British Library Electronic Table of Contents (United Kingdom)

Systematically review risks of an infant being born with low birth weight (LBW), preterm birth (PTB) or small for gestational age (SGA) among married and unmarried women. Medline, Embase, CINAHL, and bibliographies of identified articles were searched for English language studies. Studies reporting birth outcomes of married and unmarried (single and cohabitant) were included. Two reviewers independently collected data and assessed the quality of the studies for biases in sample selection, exposure assessment, confounder, analytical, outcome assessments, and attrition. Meta-analyses were performed using random effect model for both unadjusted and adjusted data and odds ratio (OR), and 95% confidence interval (CI) were calculated. Twenty-one studies of low to moderate risk of bias were inclu...

2011-01-01

Geographical variation in neonatal phenotype

Continuing the Work to Advance Normal Birth

BackgroundRecent studies have shown associations between size and body proportions at birth and health outcomes throughout the life cycle, but there are few data...Full Text Available

2006-01-01

Consanguinity and fetal growth in Pakistani Moslems.

The editor of The Journal of Perinatal Education describes the contents of this issue, which offer a broad range of resources, research, and inspiration for childbirth educators.

2005-01-01

Birth Weight and Health and Developmental Outcomes in US Children, 1997?2005

There is conflicting evidence about the effect of parental consanguinity on fetal growth. Previous studies have not always allowed for other factors that are known to affect birth weight, in particular,...Full Text Available

1987-03-01

British Library Electronic Table of Contents (United Kingdom)

The primary goal of this study was to assess the association between the full birth weight distribution and prevalence of specific developmental disabilities and related measures of health and special education services utilization in US children. Using data from the 1997?2005 National Health Interview Survey (NHIS) Sample Child Core, we identified 87,578 children 3?17?years of age with parent-reported information on birth weight. We estimated the prevalences of DDs (attention-deficit/hyperactivity disorder [ADHD], autism, cerebral palsy, hearing impairment, learning disability without mental retardation, mental retardation, seizures, stuttering/stammering, and other developmental delay) and several indicators of health services utilization within a range of birth weight categories. We cal...

2011-01-01

Risk of Peripheral Nerve Disease in Military Workingn> Dogs ...

Diabetes and risk of incident colorectal cancer in a prospective cohort of women

... The study cohort consisted of 2,123 military working dogs that were ... maintained at the Department of Defense Military Working Dog Training Center ...

2011-05-13

Decreased serum protein binding of diazepam and its major metabolite in the neonate during the first postnatal week relate to increased free fatty acid levels.

ObjectiveTo determine whether accounting for the time dynamics of diabetes exposure will change the risk estimates for colorectal cancer.Full Text Available

2010-08-01

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Green Lake Landslide and other giant and very large postglacial landslides in Fiordland, New Zealand

The protein binding of diazepam (D) and its major active metabolite N-desmethyl diazepam (DD) was investigated in vitro in the serum of 14 mothers at birth, 21 foetuses at birth, in 100 neonates between...Full Text Available

1984-01-01

British Library Electronic Table of Contents (United Kingdom)

Green Lake Landslide is an ancient giant rock slide in gneiss and granodiorite located in the deeply glaciated Fiordland region of New Zealand. The landslide covers an area of 45km2 and has a volume of about 27km3. It is believed to be New Zealands largest landslide, and possibly the largest landslide of its type on Earth. It is one of 39 known very large (106-107 m3) and giant (?108m3) postglacial landslides in Fiordland discussed in the paper. Green Lake Landslide resulted in the collapse of a 9km segment of the southern Hunter Mountains. Slide debris moved up to 2.5km laterally and 700m vertically, and formed a landslide dam about 800m high, impounding a lake about 11km long that was eventually infilled with sediments. Geomorphic evidence supported by radiocarbon dating indicates tha...

2009-01-01

Assessment of primary impacts of a hydrogen economy in New Zealand using UniSyD

the earth observer - Earth Observing System - NASA

Small economies such as New Zealand risk significant economic hardship without careful evaluation of alternatives to petroleum-based transportation due to the adverse effects of climate change and depleting international oil reserves. This paper uses an integrated multi-regional multi-fleet system dynamics model of New Zealand's energy economy to assess the primary impacts of alternative vehicle fleet technologies. Results suggest that hydrogen fuelled HICEs and FCVs may offer significantly greater economic savings than BEVs due to a much lower capital cost. Under our Base Case, 65% of the light fleet are HICEs and FCVs and 5% BEVs. Excluding hydrogen vehicles from the vehicle fleet can result in an average annual cost of US$562 per vehicle between 2015 and 2050. Co-production of hydrogen and electricity using coal gasification with carbon capture and storage is the dominant long term hydrogen production technology. (author)

2009-04-01

University of Colorado, Boulder University of Colorado Center for ...

of satellite, aircraft and ground-based observations. In ..... swarm traps by Utah Department of Food and Agriculture (DAF) personnel. Preliminary Results ..... the 150th anniversary of the book's publication and the 200th anniversary of Darwin's birth. ...... cold war submarine missions to find that Arctic Ocean ...

Timing of Births and Reproductive Success in Captive Red-tailed Phascogales, Phascogale calura

Summary of personnel, commitments, and costs ... Origin of complex land-based ecosystems (W. Friedman) ...... technology has brought about the birth of lab- ..... Baross, J.A. and S.E. Hoffman, Submarine hydrothermal vents and ...

The Long-Term Effects of Prematurity and Intrauterine Growth Restriction on Cardiovascular, Renal, and Metabolic Function

... and sperm showed an association with the oviduct epithelial tissue. Estimate of sperm storage duration At ASDP in ... Sperm heads show no particular association with the epithelial tissue. enlarge fig...

SeaWiFS Postlaunch Technical Report Series

Objective. To determine relative influences of intrauterine growth restriction (IUGR) and preterm birth on risks of cardiovascular, renal, or metabolic dysfunction in adolescent...Full Text Available

2010-01-01

Safety and Immunogenicity of Novel Recombinant BCG and Modified Vaccinia Virus Ankara Vaccines in Neonate Rhesus Macaques ?

tion and the Copenhagen symposium in many regards heralded the birth of modern marine bio-optics and the .... given to conducting a pigment intercomparison based on .... assignment of personnel and equipment, so the Hout Bay deployments were suspended. ...... submarine light field. Upwelling radiance is measured at ...

Rethinking the evolutionary theory of aging: Transfers, not births, shape senescence in social species

Although major inroads into making antiretroviral therapy available in resource-poor countries have been made, there is an urgent need for an effective vaccine administered shortly after birth, which...Full Text Available

2010-08-01

Psychosocial Characteristics of Optimum Performance in Isolated ...

The classic evolutionary theory of aging explains why mortality rises with age: as individuals grow older, less lifetime fertility remains, so continued survival contributes less to reproductive fitness....Full Text Available

2003-08-05

Prosthodontic Rehabilitation Alternative of Patients with Cleft Lip and Palate (CLP): Two Cases Report

Studies were assigned values based on whether they were anecdotal or ... or family income), work experience, birth order, military or civilian ...... observed with submarine personnel and polar expeditioners (Sandal et al., 1996). ...

Pregnant women's working conditions and their changes during pregnancy: a national study in France.

Although patients with cleft lip and palate (CLP) are not seen regularly in general dental practice, this is a frequent congenital anomaly; approximately one in every 800 live births results in a CLP....Full Text Available

2009-01-01

Origins, evolution, and phenotypic impact of new genes

In a study of 2387 employed women who had worked for more than three months of their pregnancy the data were extracted from a survey carried out on a national sample of births in France in 1981. Manual,...Full Text Available

1987-04-01

Is the operative delivery rate in low-risk women dependent on the level of birth care? A randomised controlled trial

Ever since the pre-molecular era, the birth of new genes with novel functions has been considered to be a major contributor to adaptive evolutionary innovation. Here, I review the origin and evolution...Full Text Available

2010-10-01

Infant Milk Feeding Influences Adult Bone Health: A Prospective Study from Birth to 32 Years

ObjectiveTo investigate possible differences in operative delivery rate among low-risk women, randomised to an alongside midwifery-led unit or to standard obstetric units within...Full Text Available

2011-10-01

Ichthyosis follicularis, alopecia, and photophobia (IFAP) syndrome

BackgroundPeak bone mass, attained by early adulthood, is influenced by genetic and life-style factors. Early infant feeding and duration of breastfeeding in particular, associate...Full Text Available

Ibuprofen lysine (NeoProfen) for the treatment of patent ductus arteriosus

The IFAP syndrome is a rare X-linked genetic disorder reported in nearly 40 patients. It is characterized by the triad of Ichthyosis Follicularis, Alopecia, and Photophobia from birth. Other features...Full Text Available

Finding Autonomy in Birth*

Patent ductus arteriosus (PDA) affects approximately 31% of infants whose birth weight is between 501 and 1500 g. The ductus arteriosus is a blood vessel that allows blood to bypass the pulmonary vasculature...Full Text Available

2007-01-01

Fetal tissue sampling--indications, techniques, complications, and experience with sampling of fetal skin, liver, and muscle.

Over the last several years, as cesarean deliveries have grown increasingly common, there has been a great deal of public and professional interest in the phenomenon of women ‘choosing’...Full Text Available

2009-01-01

Fetal ascites: an unusual presentation of Niemann-Pick disease type C.

Invasive prenatal testing has become an important way to evaluate fetuses at increased risk for hereditary disorders. In utero sampling of fetal skin, liver, and muscle may be required to diagnose before-birth...Full Text Available

1993-09-01

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Features and Outcomes In Utero and after Birth of Fetuses with Myocardial Disease

Two infants were seen with severe ascites detected before birth, a previously unreported presentation of Niemann-Pick disease type C. In the second infant no diagnostic storage cells were present in...Full Text Available

1989-10-01

Effects of intrauterine undernutrition on hypothalamic Kiss1 expression and the timing of puberty in female rats

Objectives. Ninety-one fetuses with dilated or hypertrophic cardiomyopathy (DCM, HCM) and myocarditis were studied. Results. Group 1 “DCM”...Full Text Available

2010-01-01

EMERGING PARENTAL GENDER INDIFFERENCE? SEX COMPOSITION OF CHILDREN AND THE THIRD BIRTH

Recent studies have suggested that intrauterine undernutrition is closely associated with the pathogenesis of diseases after birth. Perinatal undernutrition is known to disturb the development of reproductive...Full Text Available

2010-03-01

Comparison of oral and vaginal metronidazole for treatment of bacterial vaginosis in pregnancy: impact on fastidious bacteria

For much of the twentieth century, parents in the United States with two children of the same sex were more likely to have a third child than were parents with one son and one daughter, that...Full Text Available

2002-08-01

Childhood cancer and overhead powerlines: a case-control study.

BackgroundBacterial vaginosis (BV) is a common condition that is associated with preterm birth and acquisition of complex communities of vaginal bacteria that include several fastidious...Full Text Available

Arsenic-Associated Oxidative Stress, Inflammation, and Immune Disruption in Human Placenta and Cord Blood

A case-control study has been carried out to examine the occurrence of childhood cancer in relation to the proximity of overhead power lines to a child's home address at birth and to the calculated...Full Text Available

1990-12-01

An Energy-Saving Development Initiative Increases Birth Rate and Childhood Malnutrition in Rural Ethiopia

BackgroundArsenic (As) exposure during pregnancy induces oxidative stress and increases the risk of fetal loss and low birth weight.ObjectivesIn...Full Text Available

2011-02-01

APPENDIX, GLOSSARY, AND BIBLIOGRAPHY - NASA Headquarters

BackgroundEvolutionary life history theory predicts that, in the absence of contraception, any enhancement of maternal condition can increase human fertility. Energetic...Full Text Available

2006-04-01

ACCEPTABILITY OF A SELF-SAMPLING TECHNIQUE TO COLLECT VAGINAL SMEARS FOR GRAM STAIN DIAGNOSIS OF BACTERIAL VAGINOSIS

for sensitive personnel data. Based on the judgment of Task Force ...... Gunn, R ., Memorandum on Sub-Atomic Power Sources for Submarine ... Hunley, J., ed., The Birth of NASA: The Diary of T. Keith Glennan, SP-4105, ...

A diagnostic survey of infants referred for chromosome analysis in the neonatal period.

To diagnose asymptomatic bacterial vaginosis (BV), self-sampled vaginal smears were collected during a study of risk factors for preterm birth in African American women. More than 90% of those...Full Text Available

2004-01-01

A View of NASA's International Cooperation - External Relations - NASA

Examination and assessment of 140 liveborn and stillborn infants referred within two weeks of birth for chromosome analysis showed that 48 had Down's syndrome, 12 other chromosome abnormalities, 17...Full Text Available

1980-10-18

Serum thyroglobulin, a biomarker for iodine deficiency, is not associated with increased risk of upper gastrointestinal cancers in a large Chinese cohort

international vehicles, control centers, and ground support personnel. ... consists of thin membranes made from a polymer-based film and ..... (including airplanes and submarines), environmental monitoring, and control ...... sciences can use it to analyze the birth and death of stars, the formation of solar ...

British Library Electronic Table of Contents (United Kingdom)

Abstract Iodine concentrates in gastric tissue and may act as an antioxidant for the stomach. We previously showed that self-reported goiter was associated with significantly increased risk of gastric noncardia adenocarcinoma (GNCA) and nonsignificantly increased risks of gastric cardia adenocarcinoma (GCA) and esophageal squamous cell carcinoma (ESCC) in a prospective case-cohort study in a high-risk population in China. Negatively correlated with iodine levels, serum thyroglobulin (Tg) is a more sensitive biomarker of iodine deficiency than goiter. Our study aimed to determine whether baseline serum Tg was also associated with development of GNCA, GCA and ESCC in the same cohort, the Linxian General Population Nutrition Intervention Trial. Sera from -200 subjects of each case type and 40...

2011-01-01

Magnetic resonance imaging of the pediatric brain

Developmental facial paralysis: A review

The atlas presents sequences of MRI sections parallel to the orbito-meatal plane in children from birth through the age of sixteen years. Each child was studied horizontally and sagitally and three-dimensional brain images were reconstructed to facilitate accurate identification of sulci and gyri. The images show crucial aspects of brain development such as the constancy of the brain stem and primitive brain from birth onward; the development of the telencephalon, characterized by deepening of sulci and growth of the cerebral cortex surface; and the different stages of white matter myelinization.

British Library Electronic Table of Contents (United Kingdom)

The purpose of this study is to clarify the confusing nomenclature and pathogenesis of Developmental Facial Paralysis, and how it can be differentiated from other causes of facial paralysis present at birth. Differentiating developmental from traumatic facial paralysis noted at birth is important for determining prognosis, but also for medicolegal reasons. Given the dramatic presentation of this condition, accurate and reliable guidelines are necessary in order to facilitate early diagnosis and initiate appropriate therapy, while providing support and counselling to the family. The 30 years experience of our center in the management of developmental facial paralysis is dependent upon a thorough understanding of facial nerve embryology, anatomy, nerve physiology, and an appreciation of well...

2011-01-01

Impaired neonatal survival of pro-opiomelanocortin null mutants.

The malignancy significant dose from external beam radiotherapy

Intercrosses of heterozygous pro-opiomelanocortin (POMC) mice result in homozygous null progeny at lower frequencies than expected. Genotyping offspring at pre-, peri-, and postnatal stages revealed that over half of homozygous null mutants die in the early postnatal stages. To investigate the reasons for this early postnatal lethality, we analyzed in detail different parameters in the initial hours after birth. POMC null mutants born to heterozygous dams presented at birth with corticosterone levels no different from wildtype littermates, were euglycemic, and had normal liver glycogen stores. However, already 30 min after birth corticosterone levels dropped by 80% and were undetectable thereafter, while corticosterone levels in wildtype animals increased during postnatal hours. Circulating adrenaline was almost below detection 1h after birth. Blood glucose levels fell sharply in all genotypes within 30 ...

2010-12-22

The incidence of spontaneously occurring antiliver antibodies in New Zealand Black mice

In the present study an estimate is made of the malignancy significant dose from external beam radiotherapy in New Zealand utilizing data obtained in a survey conducted in 1975. This survey had been designed to assess genetically significant dose. A weighted effective dose equivalent is derived from the malignancy significant dose for direct comparison with mean per capita effective dose equivalents arising from other sources of radiation. 14 refs., 1 fig., 8 tabs.

1987-01-01

TAG Oil hunting elephants in New Zealand

The sera of NZB/BL mice have been found to be active in the complement fixation test against isogeneic liver antigens to a higher titre than the sera of CBA, C57BL and DBA/2 mice. Six sera from NZB...Full Text Available

1969-04-01

Public perceptions of wind energy developments: Case studies from New Zealand

Calgary-based TAG Oil is an exploration company that manages 4.1 million acres of major producing oil and gas fields in New Zealand. The enormous Maui field, with 4 tcf of natural gas in place, has dominated the gas market in New Zealand by meeting nearly 90 per cent of the country's energy demand at costs much lower than world prices. However, the maturing field is in decline and will cease production by 2008. New gas field discoveries will only meet 60 per cent of the country's energy requirements for 5 additional years. Unless new large reserves of gas are discovered, the supply and demand situation will get worse. Lead time to place new production on-stream requires 5 to 10 years, which creates a large supply gap over the next decade. Public resistance to coal-fired power plants, new hydroelectric dams and nuclear power has left the country with no viable alternative to natural gas. TAG Oil has taken this unique opportunity to create value ...

2005-10-01

100

Public perceptions of wind energy developments. Case studies from New Zealand

Although the public generally hold positive attitudes towards wind energy, proposals for the construction of new wind farms are often met with strong resistance. In New Zealand, where the government has recently introduced ambitious policy targets for renewable energy generation, negative perceptions of wind farms are increasingly evident and have the potential to prevent the achievement of these targets. This research sets out to examine what influences social resistance to wind farms in New Zealand. Drawing from public submissions on three wind farm proposals, a framework developed by Devine-Wright [Devine-Wright, P., 2005a. Beyond NIMBYism: towards an integrated Framework for Understanding Public Perceptions of Wind Energy. Wind Energy 8, 125-139.] was used as the basis for identification of factors affecting public perceptions of wind farms. The research found firstly that there was no apparent relationship between the proximity of ...

2009-09-15

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101

2009-09-15

102

Coal bibliography

Tissue Effect on Genetic Control of Transcript Isoform Variation

This report contains basic bibliographic data for reports held by Resource Management and Mining (Ministry of Energy) in its Coal Technical Information System (CTIS). This system contains a large number of published and unpublished reports relating to New Zealand's coal, peat, and oil shale resources. This material has been accumulated from a wide range of sources and is of widely varying quality.

1987-01-01

103

The prevalence and correlates of self-reported hearing impairment in the Ibadan Study of Ageing

Current genome-wide association studies (GWAS) are moving towards the use of large cohorts of primary cell lines to study a disease of interest and to assign biological relevance to the genetic signals...Full Text Available

2009-08-01

104

The association of circulating inflammatory markers with recurrent vascular events after stroke: a prospective cohort study

AbstractThis cohort study of 1302 persons aged ≥65 years, conducted in the Yoruba-speaking regions of Nigeria, determines the prevalence and correlates of hearing impairment (HI)...Full Text Available

2010-08-01

105

The French national prospective cohort of patients co-infected with HIV and HCV (ANRS CO13 HEPAVIH): Early findings, 2006-2010

BackgroundInflammatory markers may be associated with recurrent vascular events after stroke. We aimed to: (1) determine the association between interleukin-6, C-reactive...Full Text Available

2011-01-01

106

Survival of HIV-Infected Adolescents on Antiretroviral Therapy in Uganda: Findings from a Nationally Representative Cohort in Uganda

BackgroundIn France, it is estimated that 24% of HIV-infected patients are also infected with HCV. Longitudinal studies addressing clinical and public health questions related to...Full Text Available

107

Study protocol. A prospective cohort study of unselected primiparous women: the pregnancy outcome prediction study

BackgroundAdolescents have been identified as a high-risk group for poor adherence to and defaulting from combination antiretroviral therapy (cART) care. However, data on outcomes...Full Text Available

108

Sociodemographic factors in a pediatric chronic pain clinic: The roles of age, sex and minority status in pain and health characteristics

BackgroundThere have been dramatic changes in the approach to screening for aneuploidy over the last 20 years. However, the approach to screening for other complications of pregnancy...Full Text Available

109

Smoking and Illicit Drug Use Associations With Early Versus Delayed Reproduction: Findings in a Young Adult Cohort of Australian Twins*

Little is known about how sociodemographic factors relate to children’s chronic pain. This paper describes the pain, health, and sociodemographic characteristics of a cohort of children...Full Text Available

2010-07-01

110

Sexual Dysfunction and Symptom Impact in Men with Long-Standing Type 1 Diabetes in the DCCT/EDIC Cohort

Objective:This article examines relationships between reproductive onset and lifetime history of smoking, regular smoking, and nicotine dependence, and cannabis and other illicit...Full Text Available

2009-09-01

111

Serum Potassium and Outcomes in CKD: Insights from the RRI-CKD Cohort Study

IntroductionMale sexual dysfunction is a common complication of diabetes (DM), but the relative impact of erectile dysfunction (ED), orgasmic dysfunction (OD), and/or...Full Text Available

2009-07-01

112

Risk of cancer after low doses of ionising radiation: retrospective cohort study in 15 countries

Background and objectives: The relationship between serum potassium (S_K) and mortality in chronic kidney disease (CKD) has not been systematically investigated.Design, setting, participants,...Full Text Available

2010-05-01

113

Retrospective identification and characterization of mild cognitive impairment from a prospective population cohort

Objectives To provide direct estimates of risk of cancer after protracted low doses of ionising radiation and to strengthen the scientific basis of radiation protection standards for environmental,...Full Text Available

2005-07-09

114

Radiographic monitoring of incidental abdominal aortic aneurysms: a retrospective population-based cohort study

ObjectivesMild Cognitive Impairment (MCI) case-finding criteria have low specificity in general population studies. The present study retrospectively identifies cases...Full Text Available

2010-08-01

115

REM Sleep Percentage in Children with Autism Compared to Children with Developmental Delay and Typical Development

BackgroundAn abdominal aortic aneurysm (AAA) that is identified when the abdomen is imaged for some other reason is known as an incidental AAA. No population-based studies have...Full Text Available

116

Prevention of clinical coliform mastitis in dairy cows by a mutant Escherichia coli vaccine.

ObjectiveTo compare objective polysomnographic parameters between three cohorts: children with autism, with typical development, and with developmental delay without...Full Text Available

2010-11-01

117

Prevalence of Ocular Fundus Pathology in Patients with Chronic Kidney Disease

A prospective cohort study was undertaken in two commercial California dairies. The treatment group, 246 cows, received three doses of a whole cell bacterin of J5 Escherichia coli (mutant of E. coli...Full Text Available

1989-07-01

118

Paracetamol reduces influenza-induced immunopathology in a mouse model of infection without compromising virus clearance or the generation of protective immunity

Background and objectives: The objective of this study was to describe the prevalence of ocular fundus pathology in the Chronic Renal Insufficiency Cohort (CRIC) study, a multicenter, longitudinal study...Full Text Available

2010-05-01

119

Mortality among members of a heavy construction equipment operators union with potential exposure to diesel exhaust emissions.

BackgroundSeasonal influenza A infection affects a significant cohort of the global population annually, resulting in considerable morbidity and mortality. Therapeutic strategies...Full Text Available

2011-05-01

120

Milk fever and alert downer cows: Does hypophosphatemia affect the treatment response?

A historical prospective mortality study was conducted on a cohort of 34 156 male members of a heavy construction equipment operators union with potential exposure to diesel exhaust emissions. This...Full Text Available

1985-07-01

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121

Measuring IBS patient reported outcomes with an abdominal pain numeric rating scale: results from the proof cohort

The purpose of this prospective cohort study was to identify factors that place a dairy cow with uncomplicated milk fever (MF) at significant risk of becoming an alert downer cow (ADC) and to verify...Full Text Available

2007-05-01

122

Longitudinal Evaluation of Sexual Function in a Male Cohort: The Olmsted County Study of Urinary Symptoms and Health Status among Men

BackgroundControversy exists about how to effectively measure patient reported outcomes in IBS clinical trials. Pain numeric rating scales (NRS) are widely used in...Full Text Available

2009-12-01

123

Investigating the spatial variability in incidence of coronary heart disease in the Gazel cohort: the impact of area socioeconomic position and mediating role of risk factors

IntroductionThe presence of erectile or ejaculatory dysfunction may indicate physical problems; however, individual perceptions (e.g., sexual satisfaction) may reflect...Full Text Available

2009-09-01

124

In situ screw fixation of slipped capital femoral epiphysis with a novel approach: a double-cohort controlled study

Study objectiveThe study aim was to improve our understanding of the relationships between contextual socioeconomic characteristics and coronary heart disease (CHD)...Full Text Available

2011-02-01

125

Hostility May Explain the Association between Depressive Mood and Mortality: Evidence from the French GAZEL Cohort Study

PurposeIn situ fixation for mild to moderate slipped capital femoral epiphysis (SCFE) remains an acceptable treatment methodology in most centers. Satisfactory fixation results have...Full Text Available

2010-06-01

126

Evolution of age at menarche and at onset of regular cycling in a large cohort of French women

BackgroundDepressive mood is associated with mortality. Because personality has been found to be associated with depression and mortality as well, we aimed to test...Full Text Available

2010-02-01

127

Diesel engine exhaust and lung cancer: an unproven association.

BackgroundEarly exposure to ovarian hormones is considered to increase breast cancer incidence. The age at which the ovaries become functional is thus important.Full Text Available

2002-01-01

128

Correcting for Mortality Among Patients Lost to Follow Up on Antiretroviral Therapy in South Africa: A Cohort Analysis

1995-09-01

129

Body mass index, waist circumference, and risk of coronary heart disease: a prospective study among men and women

BackgroundLoss to follow-up (LTF) challenges the reporting of antiretroviral treatment (ART) programmes, since it encompasses patients alive but lost to programme and deaths misclassified...Full Text Available

130

Body Mass Index and Diabetes in Asia: A Cross-Sectional Pooled Analysis of 900,000 Individuals in the Asia Cohort Consortium

ObjectiveThe purpose of the study was to assess the risk of CHD associated with excess weight measured by BMI and waist circumference (WC) in two large cohorts of...Full Text Available

2010-01-01

131

Association between intratumoral lymphatic microvessel density (LMVD) and clinicopathologic features in endometrial cancer: a retrospective cohort study

BackgroundThe occurrence of diabetes has greatly increased in low- and middle-income countries, particularly in Asia, as has the prevalence of overweight and obesity; in European-derived...Full Text Available

132

Association between bacterial vaginosis or chlamydial infection and miscarriage before 16 weeks' gestation: prospective community based cohort study

BackgroundLymph node metastasis in endometrial cancer significantly decreases survival rate. Few data on the influence of intratumoral lymphatic microvessel density (LMVD) on survival...Full Text Available

133

Alcoholic Beverages and Prostate Cancer in a Prospective US Cohort Study

ObjectivesTo assess whether bacterial vaginosis or chlamydial infection before 10 weeks' gestation is associated with miscarriage before 16 weeks.DesignProspective...Full Text Available

2002-12-07

134

Adhesive capsulitis and dynamic splinting: a controlled, cohort study

Despite numerous investigations, the correlation between alcohol consumption and prostate cancer risk remains uncertain. This report investigated the association between alcohol use and prostate cancer...Full Text Available

2010-10-01

135

A report of clinical trial conducted on Toto ointment and soap products.

BackgroundAdhesive Capsulitis (AC) affects patient of all ages, and stretching protocols are commonly prescribed for this condition. Dynamic splinting has been shown effective in...Full Text Available

136

?-Blocker Use Is Associated With Decreased Risk of Sexual Dysfunction

OBJECTIVE: The efficacy of Toto ointment and soap on common skin disorders was tested. METHODOLOGY: A cohort of Nigerians with common skin conditions such as fungal and bacterial skin infections, scabies,...Full Text Available

2003-01-01

137

The German uranium miners cohort study (Wismut cohort), 1946-2003. Technical report

OBJECTIVESTo examine the association between α-blocker use and sexual dysfunction among men participating in a population-based cohort of...Full Text Available

2009-07-01

138

The effects of short term and chronic exposure to tritiated drinking water on pre- and postnatal brain development

From 1946 - 1990, i.e. from shortly after the end of World War II and the rise of the cold war until the German reunification, there had been extensive uranium mining both in Saxony and Thuringia, which formed the southern parts of the former German Democratic Republic. Mining activities started in Saxony in the Ore Mountains (German: Erzgebirge). Mining was conducted by a Soviet, since 1954 by a Soviet- German Incorporated Company named Wismut. It is estimated that about 400,000 persons may have worked in this time period with the company, most of them underground or in uranium ore processing facilities. In the early years, exposure to radiation and dust was particularly high for underground workers. After introduction of several ventilation measures and wet drilling from 1955 onwards, the levels of exposures to the various agents steadily decreased. After German reunification, it was decided by the German Federal Ministry for the Environment to save health data that were stored in ...

139

Reasons for the power failure in Auckland, New Zealand; Ursachen der Stromunterbrechung in Auckland, Neuseeland

Ingestion of HTO during oocyte maturation and continued during pre-implantation time was found to depress decidual response. At birth these offspring also showed a decrease in brain cell number. When HTO was given during pregnancy only, the offspring at birth showed a similar deficit in brain cell number. Even so, we could not demonstrate a gross deficit in oocyte maturation when HTO was ingested during sexual maturity only; however, when further continued during pregnancy, the measured newborn parameters were most severely affected. In this group, cell-multiplication in the cerebrum was severely decreased, protein synthesis was decreased, and somatic growth was also highly significantly decreased. These experiments indicate that even a short-term exposure to HTO during early pregnancy (pre-implantation) alters normal development to such an extent that it is still observable at birth. During embryonic development, HTO ...

1980-11-26

140

Early cretaceous age of orthogneiss from the Charleston Metamorphic Group, New Zealand

On February 20th 1998 Auckland, the biggest city of New Zealand, was nearly paralyzed by an extended power failure. On this day the last of four cables supplying the central business district failed and caused a five weeks lasting blackout. This failure has caused costs of 128.3 Mio NZ Dollar for the affected utility Mercury Energy Ltd. The official ministerial inquiry was published on July 21st 1998 and reproaches the utility in an unusual clear manner. (orig.) [Deutsch] Am 20. Februar 1998 wurde Auckland, die groesste Stadt Neuseelands, von einer folgenschweren Unterbrechung der Stromversorgung nahezu lahmgelegt. An diesem Tag fiel das letzte von vier 110-kV-Kabeln zur Versorgung des Innenstadtbereiches aus und verursachte damit einen 5 Wochen dauernden Stromausfall. Diese Versorgungsunterbrechung hat bisher Kosten in Hoehe von 128,3 Mio NZ Dollar (rd. 115,5 Mio DM) fuer den oertlichen Stromversorger Mercury Energy Limited verursacht. Der am 21. Juli 1998 ...

1998-11-30

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141

Feasibility study for a long-term follow-up in a historical cohort of Brazilian coal miners

Discordant U-Pb zircon isotopic data from amphibolite facies orthogneisses of the Charleston Metamorphic Group, western South Island, New Zealand, define a lower intercept age of 114#+-#18 m.y. that is interpreted as the crystallization age of the orthogneiss magmas. The upper intercept age of 1026#+-#97 m.y. reflects inherited components of Precambrian zircon derived from the source region of the magmas. The age, and whole rock chemical characteristics, indicate that the orthogneisses are part of the same phase of Early cretaceous magmatic activity that produced voluminous arc-related calc-alkaline plutonic rocks throughout western South Island. Previously published K-Ar and Rb-Sr mineral ages indicate uplift and cooling of the Charleston Metamorphic Group to less than 400deg C by 110-90 m.y. This uplift occurred as a consequence of low-angle normal faulting related to the Late Cretaceous breakup of Gondwana, and suggests that regional continental lithospheric ...

142

Successful transcatheter coil embolization of coronary artery to left ventricular fistula associated with absent pulmonary valve with tricuspid atresia in early infancy.

The first Brazilian historical mortality cohort study on miners was conducted. The cohort consisted of 3224 workers in the underground coal mining industry in southern Brazil. This industry has been operating since 1942 without compliance with any regulatory standards, since there were no relevant national regulations. Over almost 60 years, about 5000 workers were exposed to high levels of radiation. However, later radiation exposure was significantly reduced, particularly that due to radon exposure. Recent radon concentration measurements indicated an average annual exposure to radon progeny of 2.1 WLM, ranging from 0.2 to 7.2 WLM. As radon exposure in the past was unknown, it can be suggested that mine workers have not been working safely as regards the health hazard related to radon and radon progeny exposure. The cohort inclusion criteria are as follows: (a) all male employees who had worked for at least one year at the ...

2007-09-15

143

Social class, social mobility and mortality in the Netherlands, 1850-2004

Transcatheter coil embolization for coronary artery to left ventricular fistula was successfully performed in a neonate. At 30 weeks' gestation, fetal echocardiography showed a hypoplastic right ventricle with intact ventricular septum, absent pulmonary valve, tricuspid atresia, and marked distension of the right coronary artery. After birth, the neonate had congestive heart failure and the electrocardiogram showed myocardial ischemic changes in the left ventricular area. Aortography showed a dilated right coronary artery arising from the ascending aorta and draining into the left ventricle. Transcatheter coil embolization was carried out on the 9th day after birth. Since the procedure, no myocardial ischemic changes have been detected. Transcatheter coil embolization is a useful therapy for coronary artery fistula associated with myocardial ischemia. PMID:15564713

2004-12-01

144

British Library Electronic Table of Contents (United Kingdom)

This study uses data from a random sample of births in the Netherlands during the period 1850-1922 to examine the relationships between social class, social mobility and mortality at middle and old age. Population registers and personal cards covering the period from 1850 to 2004 for all Dutch provinces were used to reconstruct individual life histories of 14,900 births. For men we did not find an effect of the social class of origin (using two different SES-classifications) on mortality in age group 18 to 35. We also did not observe an effect of own social class on mortality after age 35. For women effects of social class of origin and social class of husband were generally absent as well. Our conclusion is that the standard ideas about the negative effects of processes of industrializati...

2011-01-01

145

Nutritional state, maturational delay on electroencephalogram, and developmental outcome in extremely low birth weight infants

British Library Electronic Table of Contents (United Kingdom)

The aim of this study is to clarify the relation among developmental outcome, nutritional state during the neonatal period, maturational electroencephalographic changes. Thirteen extremely low birth weight infants who completed 6- or 9-year follow-up were a subject of this study. Undernutrition was defined as enteral feeding below 100mL/kg/day at 3weeks of age. Dysmature patterns were defined as the persistence of EEG patterns 2weeks or more immature for post-conceptional age. IQ was examined at 6 and 9years of age. Body height and weight, and head circumference at 6years of age were stratified by the percentile grades. Full and verbal IQ was significantly lower in infants with undernutrition than those with normal nutrition. Among infants with undernutrition, those with persistent dysmatu...

2010-01-01

146

Job satisfaction patterns of scientists and engineers by status of birth

British Library Electronic Table of Contents (United Kingdom)

The latest figures published by the Science and Engineering Indicators report reveals that in 2003, 33% of faculty in science and engineering departments at research universities were foreign-born, a number that has more than doubled in thirty years. Foreign-born faculty members comprise an important part of the scientific enterprise that has been understudied. The purpose of this study is to examine the job satisfaction patterns of scientists and engineers by status of birth using a very large and comprehensive National Science Foundation (NSF) dataset, the Survey of Doctoral Recipients (SDR). The results of the study indicate that foreign-born scientists and engineers are less satisfied in several areas of their work life as compared to their US-born peers.

2011-01-01

147

Intra uterine growth retardation: Association with organochlorine pesticide residue levels and oxidative stress markers

British Library Electronic Table of Contents (United Kingdom)

Intra uterine growth retardation (IUGR) is a major complication of pregnancy, affecting ~5% to 10% of newborns. Hexachlorocyclohexane (HCH) is an organochlorine pesticide that consists of eight stereoisomers and g-isomer is the only isomer that possesses insecticidal activity. The aim of the present study was to analyze the OCP residues in maternal and cord blood of women and to assess the level of oxidative stress markers as well as to establish correlation with OCP levels. Fifty women delivering neonates with low birth weight (IUGR) and equal number of women delivering normal birth weight babies (control) were recruited. We have observed higher levels of g-HCH and T-HCH and increased oxidative stress markers in IUGR subjects versus control subjects. Significant correlations were also fou...

2011-01-01

148

Plugging the biopsy tract in rabbit liver : gelfoam, fibrin sealant and NBCA

Placental transfer of 14C-hexoprenaline. [Rabbits

To evaluate the effect of plugging the biopsy tract in rabbit liver and the pathologic changes caused by plugging materials. Thirty-two New Zealand White rabbits were divided into four groups (eight rabbits in each) and compared with one another. They were labeled group A (control), B (gelfoam), C (fibrin sealant) or D (NBCA). the liver was exposed and biopsied with an 18G disposable biopsy gun. The inner Tru-cut needle was withdrawn and plugging was undertaken through the outer cannula of the biopsy gun. Bleeding times of each material were compared. The rabbits were sacrificed and pathologically evaluated for 17 days.

1998-07-01

149

Placental transfer of 14C-hexoprenaline

The placental transfer of a single intravenous injection of 14C-hexoprenaline was studied in eight pregnant New Zealand white rabbits. Maternal and fetal blood was sampled intermittently for 60 minutes after the injection. An initial rapid decrease in the levels of 14C-hexoprenaline in maternal blood was followed by a second slower phase, whereas fetal levels remained insignificant. The conclusion, therefore, is that the rapid improvement in fetal heart rate after the administration of a single maternal intravenous injection of hexoprenaline in the treatment of fetal distress is due to the action on the uterus and/or on maternal cardiovascular function, and not to direct stimulation of the fetus.

1982-02-01

150

1982-02-01

151

Lessons from Auckland

U.S. military workingn> dogs with Vietnam service: definition and characteristics of the cohort.

The major distributor and retailer of electrical power to Auckland, New Zealand, is Mercury Energy Limited. Following the sequential failure of the four 110kV underground cables, two gas-filled and two oil-filled, which supply the central business district, power was interrupted for 29 days from the 20th February 1998. A government inquiry was instituted, to examine what happened, why, and what lessons could be drawn for the future. Inadequacies in Mercury Energy`s cable maintenance and operating procedures were identified. The findings of the inquiry and its recommendations are reported. (UK)

1998-08-01

152

Natural remedy use in a prospective cohort of breast cancer patients in southern Sweden

We verified and corrected inaccuracies in descriptive profile information on military working dogs (MWDs) that died from 1965 to 1980 and were reported in the Armed Forces Institute of Pathology Registry of Veterinary Pathology. Using other available military records, we determined which dogs served in Vietnam. Identified were 3,895 MWDs with a unique identity tattoo that served in Vietnam, of which 2,389 served exclusively with U.S. military forces and died in Vietnam. Another 479 Vietnam veteran MWDs completed their service elsewhere. This overall effort resulted in signalment corrections, generally age at death, in 21% of the Registry MWD accessions during the study period. The improved definition and characterization of the Vietnam cohort will lead to greater precision in epidemiologic investigations of the health effects from the Vietnam experience in U.S. military working dogs. PMID:7885593

1994-11-01

153

British Library Electronic Table of Contents (United Kingdom)

Abstract Background. Complementary and alternative medicine (CAM) use is common among breast cancer patients. Several CAM therapies may have negative side effects or interact with conventional therapies. We studied biologically based CAM use with and without vitamins/minerals in relation to patient and tumor characteristics as well as treatment in an ongoing prospective cohort of 855 primary breast cancer patients. Methods. Patients from two hospitals in southern Sweden were included. Pre-operative and follow-up questionnaires containing questions on food intake, lifestyle, and concomitant medications, including natural remedies, were completed up to five years postoperatively. Clinical information was obtained from clinical records and tumor characteristics from pathology reports. Results...

2011-01-01

154

Genome-wide association study identifies variants in the CFH region associated with host susceptibility to meningococcal disease

British Library Electronic Table of Contents (United Kingdom)

Meningococcal disease is an infection caused by Neisseria meningitidis. Genetic factors contribute to host susceptibility and progression to disease, but the genes responsible for disease development are largely unknown. We report here a genome-wide association study for host susceptibility to meningococcal disease using 475 individuals with meningococcal disease (cases) and 4,703 population controls from the UK. We performed, in Western European and South European cohorts (consisting of 968 cases and 1,376 controls), two replication studies for the most significant SNPs. A cluster of complement factor SNPs replicated independently in both cohorts, including SNPs within complement factor H (CFH) (rs1065489 (p.936D

2010-01-01

155

Body mass index and risk of colorectal cancer in Chinese Singaporeans

British Library Electronic Table of Contents (United Kingdom)

AbstractBACKGROUND: The authors chose to examine the association between body mass index (BMI) and incident colorectal cancer across the spectrum of BMI, including underweight persons, because detailed prospective cohort data on this topic in Asians is scarce, as is data on underweight persons (BMI, <18.5 kg/m2) in any population. METHODS: Analysis of the Singapore Chinese Health Study included 51,251 men and women aged 45-74 years enrolled in 1993-1998 and followed through 2007. Incident cancer cases and deaths among cohort members were identified through record linkage, and 980 cases were identified. Cox regression models were used to investigate the association of baseline BMI with risk of incident colorectal cancer during a mean of 11.5 years of follow-up. RESULTS: A significant, U-sha...

2011-01-01

156

NAI: Year 4 Annual Report - NASA Astrobiology Institute

Low birthweight infants and total parenteral nutrition immediately after birth. II. Randomised study of biochemical tolerance of intravenous glucose, amino acids, and lipid.

His talk was based on the suggestion that life on Earh has been a long but accelerating ..... a New Class of Submarine Hydrothermal System"; April 29, 2002 , ..... of media personnel, including radio, television, newspapers, and magazines. ...... "The Birth of Stars and Planets" (Denver Museum of Nature and Science ...

157

Lee Oral History, January 16, 2008 - Johnson Space Center

This randomised study aimed to compare the biochemical tolerance of three parenteral regimens administered during the first 48 hours of life. Twenty nine infants were randomised to either: (a) glucose...Full Text Available

1995-07-01

158

Comparative effects of scaffold pore size, pore volume, and total void volume on cranial bone healing patterns using microsphere-based scaffolds

Jan 16, 2008 ... home town, and awards, as well as the ground personnel. .... I was also awarded six air medals, which were given based on the number of missions ..... We took these projects from birth to grave. .... Japanese sonar on their submarine. About that time another airplane dropped a bomb ...

159

The Copenhagen County child cohort: design of a longitudinal study of child mental health

Bony craniofacial deficits resulting from injury, disease, or birth defects remain a considerable clinical challenge. In this study, microsphere-based scaffold fabrication methods were use to...Full Text Available

2009-06-01

160

Risk of Peripheral Nerve Disease in Military Workingn> Dogs Deployed in Operations Desert Shield/Storm.

Epidemiological studies of psychopathology in the first years of life are few, and the association between mental health problems in infancy and psychiatric disturbances later in life has not been systematically investigated. The aim of the present project was to study mental health problems and possibilities of intervention from infancy and onward.

2005-01-01

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161

No difference in antibody titers against xenotropic MLV related virus in prostate cancer cases and cancer-free controls

A population-based, cohort study was conducted to determine the importance of Gulf War deployment to Southwest Asia, from 1 August 1990 to 31 December 1991, in explaining neurologic mortality and peripheral nerve disease among United States military worki...

2003-01-01

162

British Library Electronic Table of Contents (United Kingdom)

New ELISA assays were developed to measure immunoreactivity for XMRV. Antibody titers were measured in a cohort of prostate cancer cases and cancer free controls from the central United States. No statistically significant differences were observed in immunoreactivity between cases and controls for either the XMRV-env or the XMRV-gag antigen.

2011-01-01

163

Long-Term Adherence to Antiretroviral Treatment and Program Drop-Out in a High-Risk Urban Setting in Sub-Saharan Africa: A Prospective Cohort Study

Liver function abnormalities and outcome in patients with chronic heart failure: data from the Candesartan in Heart Failure: Assessment of Reduction in Mortality and Morbidity (CHARM) program

BackgroundSeventy percent of urban populations in sub-Saharan Africa live in slums. Sustaining HIV patients in these high-risk and highly mobile settings is a major future challenge....Full Text Available

164

Is the association between optimistic cardiovascular risk perceptions and lower rates of cardiovascular disease mortality explained by biomarkers of systemic inflammation or endothelial function? A case-cohort study

AimsThe prevalence and importance of liver function test (LFT) abnormalities in a large contemporary cohort of heart failure patients have not been systematically evaluated.Full Text Available

2009-02-01

165

Clinical Characteristics and Outcomes of Patients with Acute Coronary Syndrome and Prior Coronary Artery Bypass Grafting in a Large Middle Eastern Cohort

BackgroundMore optimistic perceptions of cardiovascular disease risk are associated with substantively lower rates of cardiovascular death among men. It remains unknown whether this...Full Text Available

166

Wealth accumulation among U.S. immigrants: A study of assimilation and differentials

Background:Acute Coronary Syndrome (ACS) can occur in patients with prior coronary artery bypass grafting (CABG). In the Gulf Registry of acute coronary events (Gulf RACE), we identified...Full Text Available

167

British Library Electronic Table of Contents (United Kingdom)

Data from the New Immigrant Survey are used to study wealth differentials among U.S. legal permanent residents. This study is unique in its ability to account for wealth held in the U.S. and that held abroad and yields several key findings. First, relative to immigrants from Western Europe, Australia, Canada, and New Zealand (who have median wealth similar to native born non-Hispanic whites), other immigrant groups have lower levels of total wealth even after accounting for permanent income and life course characteristics. Second, time in the U.S. is positively associated with the wealth of married immigrants, yet this relationship is not statistically significant for single immigrants. Third, differences in the means of measured characteristics between Western European immigrants and thos...

2011-01-01

168

Transportation fuels from indirect coal liquefaction. [US DOE; reviews and considers work in other countries

The Economics of Policy Borrowing and Lending: A Study of Late Adopters

Coal can be converted to liquid fuels via three generically defined technologies: pyrolysis, direct hydroliquefaction, and indirect liquefaction. This paper presents a general overview of the indirect liquefaction technology and a discussion of processes tht are commercially available as well as those in the development stage. Finally, the objective of the DOE research and development program in conversion of synthesis gas derived from coal to transportation fuels is summarized. The current outlook for indirect liquefaction is encouraging. New facilities are being built in South Africe and New Zealand, and commercial plants could be designed and built for operation in the United States using proven technology. At the same time, developments in gasification as well as liquefaction catalysts and reactor technology promise significant improvements in indirect liquefaction processes in the years to come.

1982-01-01

169

Species in the genus Turritopsis (Cnidaria, Hydrozoa): a molecular evaluation:

The article draws on interpretive frameworks from diffusion research and social network analysis to explore one particular "travelling reform"--outcomes-based education--that went global. The argument is made that by virtue of studying late adopters of a travelling reform one is examining globalisation. The cases in point for late adoption are Central Asian education systems (in particular Mongolia and Kyrgyz Republic) that borrowed outcomes-based education reforms at a time when the popularity of similar reforms were already in decline in other countries, notably in New Zealand, Australia and South Africa. The emphasis of this study is on the timing of policy borrowing, and it is suggested that more attention is given to the economics of policy borrowing. (Contains 3 notes.)

2006-11-01

170

British Library Electronic Table of Contents (United Kingdom)

Abstract Mitochondrial ribosomal gene sequences were used to investigate the status of several populations of hydromedusae belonging to the genus Turritopsis (family Oceaniidae). Several nominal species have been described for this genus, but most of them had been synonymized and attributed to one cosmopolitan species, Turritopsis nutricula. A recent revision based on morphological and reproductive characters, however, has shown that many different populations can be distinguished and that several of the nominal Turritopsis species are likely valid biological species. Our investigation using molecular sequence data of 16S mitochondrial gene confirms these results. The Mediterranean Turritopsis must be attributed to Turritopsis dohrnii and the Turritopsis of New Zealand must be referred to ...

2007-01-01

171

Smoking and Aboriginal and Torres Strait Islander and Maori children

British Library Electronic Table of Contents (United Kingdom)

Abstract Smoking and the deaths and suffering it causes are more common among Aboriginal and Torres Strait Islander peoples and Maori than other Australians and New Zealanders. While, many tobacco control activities that are not specifically targeted at children will have a positive impact on child health, this review concentrates on recent tobacco control research on pregnant women and children. The important tasks are to reduce smoking by pregnant Maori and Aboriginal and Torres Strait Islander women to reduce infant and child exposure to second-hand smoke and to reduce smoking initiation of children and adolescents. Health professionals who want to reduce the suffering caused by smoking among Maori and Aboriginal and Torres Strait Islander children can be guided by much new relevant res...

2010-01-01

172

Hydroxyapatite coating enhances polyethylene terephthalate artificial ligament graft osseointegration in the bone tunnel

British Library Electronic Table of Contents (United Kingdom)

The purpose of this study was to investigate whether hydroxyapatite (HAp) coating could induce polyethylene terephthalate (PET) artificial ligament graft osseointegration in the bone tunnel. Twenty-four New Zealand white rabbits underwent artificial ligament graft transplantation in bilateral proximal tibia tunnels. One limb was implanted with HAp-coated PET graft, and the contralateral limb was implanted with non-HAp-coated PET graft as control. The rabbits were randomly sacrificed at four and eight?weeks after surgery. The loads to failure of the experimental group at eight?weeks were significantly higher than those of the control group (p?=?0.0057). Histologically, application of HAp coating induced new bone formation between graft and bone at eight?weeks compared with the controls. Rea...

2011-01-01

173

How Much Does the Midline Incision Add to Urethral Diameter After Tubularized Incised Plate Urethroplasty? An Experimental Animal Study

British Library Electronic Table of Contents (United Kingdom)

PurposeWe objectively quantified the gain in urethral diameter and the effect of stenting after tubularized incised plate urethroplasty in a rabbit hypospadias model. Materials and MethodsWe created a hypospadias model in 12 New Zealand white male rabbits by excising the ventral urethra. A 3 cm tattoo line was made longitudinally in the dorsal urethral plate midline. Two weeks later a 2 cm relaxing incision was made in the middle part of the tattooed line. The stretched incision width between the tattooed edges was measured, followed by urethral plate tubularization. Six rabbits were stented and 6 were nonstented. Two weeks later the animals were sacrificed and the distance separating the tattoo was measured at the midpoint of the tattooed line. Transverse sections at this point were exami...

2011-01-01

174

Current account deficits and sustainability: Evidence from the OECD countries

British Library Electronic Table of Contents (United Kingdom)

Whether or not a current account deficit sustainable has important implications for policy. If the current account deficits of a nation is sustainable, then it implies that the government should have no incentive to default on its international debt. In this article we examine whether or not the current account deficits for the OECD countries can be characterized by a unit root process with regime switching. The econometric methodology allows us to distinguish periods that are associated with unsustainable outcomes from those in which the intertemporal national long-run budget constraint (LRBC) holds. Among the main results, it is found that it is very likely that the LRBC will not hold for the Australia, the Czech Republic, Finland, Hungary, New Zealand, Portugal or Spain, thus signifying...

2011-01-01

175

Comparative requirements for electric energy for production of hydrogen fuel and/or recharging of battery electric automobile fleets in New Zealand and the United States

British Library Electronic Table of Contents (United Kingdom)

Within the current outlook for sustainable electric energy supply with concomitant reduction in emission of greenhouse gases, accelerated attention is focusing on the long-term development of hydrogen fuel cell and all-electric battery vehicles to provide alternative fuels to replace petroleum-derived fuels for automotive national fleets. The potential varies significantly between large industrially developed nations and smaller industrially developing nations. The requirement for additional electric energy supply from low-specific energy renewable resources and high-specific energy nuclear resources depends strongly on individual national economic, environmental, and political factors. Analysis of the additional electric energy supply required for the two potential large-scale technologie...

2010-01-01

176

Should Male Gender Assignment be Considered in the Markedly Virilized Patient With 46,XX and Congenital Adrenal Hyperplasia?

British Library Electronic Table of Contents (United Kingdom)

Purpose We assess the outcome in 46,XX men with congenital adrenal hyperplasia who were born with Prader 4 or 5 genitalia and assigned male gender at birth. Materials and Methods After receiving institutional review board approval and subject consent we reviewed the medical records of 12 men 35 to 69 years old with 46,XX congenital adrenal hyperplasia, of whom 6 completed social and gender issue questionnaires. Results All subjects were assigned male gender at birth, were diagnosed with virilizing congenital adrenal hyperplasia at age greater than 3 years and indicated a male gender identity with sexual orientation to females. Ten of the 12 subjects had always lived as male and 2 who were reassigned to female gender in childhood subsequently self-reassigned as male. Nine of the 12 men had ...

2010-01-01

177

Brain development during the first year of life. Quantitative assessment with ADC imaging

The newborn infant: a missing stage in developmental psychology

Brain development during the first year of life was assessed quantitatively using apparent diffusion coefficient (ADC) images constructed from diffusion-weighted MR image data. The imaging plane was coronal at the section of the pons. The cerebral peduncle, internal capsule, corona radiata, superior longitudinal fasciculus and thalamus were selected for evaluation of their ADC values. A diffusion sensitive gradient was added in the anteroposterior direction. Thus the orientation of nerve fibers in the cerebral peduncle, internal capsule and corona radiata was perpendicular to it, and that in the superior longitudinal fasciculus was parallel to it. In neonates, the cerebral peduncle and internal capsule, having been moderately myelinated at birth, showed the slowest diffusion. The corona radiata and superior longitudinal fasciculus, having been unmyelinated at birth, showed the fastest diffusion. The thalamus had intermediate diffusion. These ...

178

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Abstract Although neonatology, the study of the newborn, is well established in medical science, psychological research on the newborn is relatively scarce. Can we justify this period as a distinct stage of human development in Psychology? This introductory article considers the unique characteristics of the neonatal period, the impact of the transition to extrauterine life, including the impact of birth itself, and the stages of brain development that characterize this period. It presents evidence of an intentional, intersubjective neonate, and uses behavioural and neuroscientific evidence to argue that the neonate's early social preferences and responses indicate a unique, sensitive, experience-expectant stage of development. The authors of this issue agree in proposing that the newborn ...

2011-01-01

179

The astronomical orientation of the urban plan of Alexandria

THE DISAPPEARING NUTRITIONAL BIAS AGAINST CHINESE GIRLS

Alexander the Great founded Alexandria in 331 BC. The newly founded town was conceived as an orthogonal grid based on a main longitudinal axis, later called Canopic Road. We analyse here the astronomical orientation of the project and propose that the main axis was deliberately oriented towards the rising sun on the day of birth of Alexander the Great. The argument is admittedly speculative as any Archaeoastronomy argument not backed up by written sources. However, it is nested accurately into the archaeological records and into what is known on the foundation of the town. Further, a topographical analysis is given to sustain the thesis.

2011-01-01

180

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This paper investigates whether China has reached postnatal nutrient intake equality between boys and girls, despite an exceptionally high ratio of boys to girls at birth, after dramatic technological advances in prenatal sex determination, rapid increases in income, and improved educational opportunities for females. Dominance methods applied to data from the Chinese Health and Nutrition Surveys (selected years 1991-2004) reveal no bias in calorie consumption between girls and boys. We find some weak evidence of protein bias toward boys in 1991, but it disappeared by 2004. (JEL I32, O15, N35)

2011-01-01

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181

Influence of chromatin molecular changes on RNA synthesis during embryonic development

Androgenic induction of brain sexual dimorphism depends on photoperiod in meadow voles.

Two aspects of the chromatin repeat length (r_l) are discussed: (i) Why is r_l longer for slowly dividing cells than in rapidly dividing cells?, and (ii) Why is the temporal evolution of r_l a decreasing function of time (t) in mammalian cortical neurons whereas it is an increasing function of t for granule cells around the time of birth? These questions are discussed in terms of a hypothesis which assumes a correlation between deoxyribonucleic acid (DNA) packaging, transcription, and replication. (author). 27 refs.

182

Effect of lead in the laboratory mouse. 1. Influence of pregnancy upon absorption, retention, and tissue distribution of radiolabeled lead

Male meadow voles maintained in a long photoperiod (LP) from birth have heavier brains than do females, but in short photoperiods (SP) this sex dimorphism is absent. Testosterone propionate (TP) administration on the second day of postnatal life produced significant increases in brain weight of LP but not SP females at 35 days of age. Short daylengths reduce the responsiveness of the meadow vole nervous system to the masculinizing effects of perinatal testosterone and may, in part, mediate the seasonally reduced sex difference in brain weight. PMID:8446686

1993-02-01

183

Effect of lead in the laboratory mouse. 1. Influence of pregnancy upon absorption, retention, and tissue distribution of radiolabeled lead

Whole-body retention and excretion following a single oral dose of radiolabeled lead (/sup 203/Pb) in chronically lead-exposed pregnant BK:W mice were examined over 10-13 days. This was compared with values in similarly treated nonpregnant females and in ip injected females. Whole-body and bone retention were greater in injected than in orally dosed nonpregnant females; gastrointestinal absorption was estimated from this difference. Whole-body retention in the pups was measured at birth and at the end of the experiment. Whole-body retentions in pregnant females and in their pups at birth were significantly raised after treatment at Gestational Day 17, but not after treatment at Gestational Day 11, 14, 20, 23, or 26. Pup body burdens at birth were significantly and positively correlated with maternal retention. Measurement of radioactivity in bone, kidney, brain, heart, and liver of adults at the end of the experiments ...

1986-12-01

184

High resolution sequence stratigraphy of Miocene deep-water clastic outcrops, Taranaki coast, New Zealand

Whole-body retention and excretion following a single oral dose of radiolabeled lead ("2"0"3Pb) in chronically lead-exposed pregnant BK:W mice were examined over 10-13 days. This was compared with values in similarly treated nonpregnant females and in ip injected females. Whole-body and bone retention were greater in injected than in orally dosed nonpregnant females; gastrointestinal absorption was estimated from this difference. Whole-body retention in the pups was measured at birth and at the end of the experiment. Whole-body retentions in pregnant females and in their pups at birth were significantly raised after treatment at Gestational Day 17, but not after treatment at Gestational Day 11, 14, 20, 23, or 26. Pup body burdens at birth were significantly and positively correlated with maternal retention. Measurement of radioactivity in bone, kidney, brain, heart, and liver of adults at the end of the experiments showed ...

185

Deep-ocean record of major late Cenozoic rhyolitic eruptions from New Zealand

Approximately 700m of deep water clastic deposits of Mt. Messenger Formation are superbly exposed along the Taranaki coast of North Island, New Zealand. Biostratigraphy indicates the interval was deposited during the time span 10.5-9.2m.y. in water depths grading upward from lower bathyal to middle-upper bathyal. This interval is considered part of a 3rd order depositional sequence deposited under conditions of fluctuating relative sea-level, concomitant with high sedimentation rates. Several 4th order depositional sequences, reflecting successive sea-level falls, are recognized within the interval. Sequence boundaries display a range of erosive morphologies from metre-wide canyons to scours several hundred metres across. All components of a generic lowstand systems tract--basin floor fan, channel-levee complex and progading complex--are present in logical and temporal order. They are repetitive through the interval, with the relatively shallower-water components ...

1995-08-01

186

Risk of Colon Cancer and Coffee, Tea, and Sugar-Sweetened Soft Drink Intake: Pooled Analysis of Prospective Cohort Studies

A 12 m.y. record of large rhyolitic eruptions from the Coromandel (CVZ) and Taupo (TVZ) volcanic zones of New Zealand is contained in cores retrieved by Leg 181 of the Ocean Drilling Program. Site 1124, located 670 km from the TVZ, has a maximum of 134 macroscopic tephra layers with a total thickness of 13.18 m. These units, along with between 7 and 63 tephras from 3 other sites, were dated by a combination of magnetostratigraphy, biostratigraphy, isothermal plateau fission track determinations, and geochemical correlation with onshore tephra deposits. Additional time control for the last 3 m.y. came from an orbitally tuned, benthic, oxygen isotope profile for Site 1123. Results extend the incomplete terrestrial record of volcanism by placing the first major rhyolitic eruption in the CVZ at c. 12 Ma, c. 1.6-1 m.y. earlier than previously known. Tephras became thicker and more frequent from the late Miocene into the Quaternary - a trend that probably reflected (1) ...

2004-09-01

187

British Library Electronic Table of Contents (United Kingdom)

Background The relationships between coffee, tea, and sugar-sweetened carbonated soft drink consumption and colon cancer risk remain unresolved. Methods We investigated prospectively the association between coffee, tea, and sugar-sweetened carbonated soft drink consumption and colon cancer risk in a pooled analysis of primary data from 13 cohort studies. Among 731 441 participants followed for up to 6-20 years, 5604 incident colon cancer case patients were identified. Study-specific relative risks (RRs) and 95% confidence intervals (CIs) were estimated using Cox proportional hazards models and then pooled using a random-effects model. All statistical tests were two-sided. Results Compared with nonconsumers, the pooled multivariable relative risks were 1.07 (95% CI = 0.89 to 1.30, Ptrend = ...

2010-01-01

188

Occurrence of hearing loss in a cohort of civilians employed at a US Navy industrial facility. Interim report

Frequency and risk factors of gout flares in a large population-based cohort of incident gout

Although hearing loss has been the focus of national surveys in the civilian population, these surveys typically do not include occupational exposure information. Furthermore, very few studies have addressed this problem in the military, particularly in industrial settings. Audiometric data, including hearing loss information, recorded and stored in the prototype application of the Navy's Occupational Health Information Management System (NOHIMS) has not been systematically evaluated to identify military and civilian populations that are at high risk for hearing loss. The objective of this study was to determine the prevalence of hearing loss in a cohort of Navy civilian workers employed at an industrialized facility. It is both appropriate and timely to look at hearing loss among civilian workers, as well as among the military, especially in relation to the recent Presidential initiative that established a government-wide five year goal of reducing ...

1986-12-18

189

British Library Electronic Table of Contents (United Kingdom)

Objective. So far, few data are available to characterize the flare history of patients with gout. The objective of this study was to describe the frequency and risk factors of gout flares with special consideration of the comorbidity. Methods. A cohort study was conducted in a UK general practice database (The Health Improvement Network) including all patients aged 20-89 years diagnosed with incident gout between the years 2000 and 2007. Results. In this study, 23 857 incident gout patients (mean age 61.9 years) were included, overall incidence rate was 2.68 (95% CI 2.65, 2.72) per 1000 person-years. The proportion of patients with at least one flare during the follow-up period (mean 3.8 years) was 36.9% (n = 8806). A history of ischaemic heart disease [hazard ratio (HR) 1.12 (95% CI 1.06...

2011-01-01

190

Diesel engine exhaust and lung cancer: An unproven association

A phase 1 study of BMS-275183, a novel oral analogue of paclitaxel given on a daily schedule to patients with advanced malignancies

The risk of lung cancer associated with diesel exhaust has been calculated from 14 case-control or cohort studies. We evaluated the findings from these studies to determine whether there is sufficient evidence to implicate diesel exhaust as a human lung carcinogen. Four studies found increased risks associated with long-term exposure, although two of the four studies were based on the same cohort of railroad workers. Six studies were inconclusive due to missing information on smoking habits, internal inconsistencies, or inadequate characterization of diesel exposure. Four studies found no statistically significant association. It can be concluded that short-term exposure to diesel engine exhaust (20 years) increases the risk of lung cancer for locomotive engineers, brakemen, and diesel engine mechanics. There is inconsistent evidence on the effects of long-term exposure to diesel exhaust in the trucking industry. There is no evidence for a ...

1995-09-01

191

British Library Electronic Table of Contents (United Kingdom)

Summary Purpose BMS-275183 is an oral C-4 methyl carbonate analogue of paclitaxel that has the same mechanism of action, stabilization of tubulin polymerization. The present study was designed to: (i) assess the safety and tolerability of BMS-275183, and (ii) determine a suitable Phase II dose of BMS-275183 when given on a continuous daily schedule to patients with advanced solid tumor(s). Methods This was a multi-institutional, open-label, Phase I, single-arm dose escalation study in which cohorts of eligible patients with advanced malignancies were treated with BMS-275183 orally on a continuous daily schedule. The starting dose level was 6?mg/m2/day administered once daily. Cohorts of 3 patients were treated at each dose level provided no dose-limiting toxicities (DLTs) were observed. Ea...

2011-01-01

192

Health effects[1997 Scientific Report of the Belgian Nuclear Research Centre

Chernobyl Studies Project. Working Group 7.0, environmental transport and health effects. Progress report, February 1994

The objectives of the research in the field of epidemiology , performed at the Belgian Nuclear Research Centre SCK-CEN are (1) to study cancer mortality and morbidity in nuclear workers in Belgium; (2) to document the feasibility of retrospective cohort studies in Belgium; (3) to participate in the IARC study. For radiobiology, the main objectives are: (1) to elucidate the mechanisms of the effects of ionizing radiation on the mammalian embryo during the early phase of its development, (2) to assess the genetic risks of maternal exposure to ionizing radiation, (3) to elucidate the mechanisms by which damage to the brain and mental retardation are caused in man after prenatal irradiation. The main achievements in these domains for 1997 are presented.

1998-07-01

193

High success rate of hematopoietic cell transplantation regardless of donor source in children with very high-risk leukemia.

The focus of the Chernobyl Studies Project has now turned to the issue of health effects from the Chernobyl accident. Currently, we are involved in and making progress on the case-control and co-hort studies of thyroid diseases among Belarussian children. Dosimetric aspects are a fundamental part of these studies. We are working to implement similar studies in Ukraine. A major part of the effort of these projects is supporting these studies, both by providing methods and applications of dose reconstruction and by providing support and equipment for the medical teams.

1994-04-01

194

Effect of dietary fatty acid intake on prospective weight change in the Heidelberg cohort of the European Prospective Investigation into Cancer and Nutrition

We evaluated 190 children with very high-risk leukemia, who underwent allogeneic hematopoietic cell transplantation in 2 sequential treatment eras, to determine whether those treated with contemporary protocols had a high risk of relapse or toxic death, and whether non-HLA-identical transplantations yielded poor outcomes. For the recent cohorts, the 5-year overall survival rates were 65% for the 37 patients with acute lymphoblastic leukemia and 74% for the 46 with acute myeloid leukemia; these rates compared favorably with those of earlier cohorts (28%, n = 57; and 34%, n = 50, respectively). Improvement in the recent cohorts was observed regardless of donor type (sibling, 70% vs 24%; unrelated, 61% vs 37%; and haploidentical, 88% vs 19%), attributable to less infection (hazard ratio [HR] = 0.12; P = .005), regimen-related toxicity (HR = 0.25; P = .002), and leukemia-related death (HR = 0.40; P = .01). Survival probability ...

2011-05-25

195

Some technical subjects on production of hydrocarbon fuel from synthetic gas

OBJECTIVE: To evaluate the association between fatty acid (alpha-linolenic acid (ALA), EPA, DHA, palmitic, stearic, oleic, linoleic and arachidonic acids) intake and prospective weight change in the Heidelberg cohort of the European Prospective Investigation into Cancer and Nutrition. DESIGN: Prospective cohort study with mean follow-up time of 6.5 years. In a total of 9182 men and 10867 women aged 35 to 64 years, from body weight measurement at recruitment and calibrated body weight during follow-up, weight change was expressed as mean annual weight change relative to baseline weight (%/year) and categorised into four groups (weight loss, or =2.5 to or =7.5%/5 years). Energy-adjusted dietary fatty acid intake data were estimated from the FFQ completed at baseline. Multivariate linear regression models as well as multinomial logistic regression analyses (carbohydrate replacement models) were conducted. RESULTS: Stearic acid intake was linearly ...

2010-01-01

196

Intersociety energy conversion engineering conference, 20th, Miami Beach, FL, August 18-23, 1985, Proceedings. Volumes 1, 2, and 3

Since fuel oil meeting the requirements of current petroleum products can be produced by SASOL F-T synthetic process, the manufacturing process of hydrocarbon fuel oil from the coal-derived synthesis gas, downstream processes are being successively investigated. Mobile M-gasoline, MTG, process which produces gasoline from the natural gas-derived synthesis gas through methanol went into commercial operation in New Zealand in 1986. Although the gasoline suffices the quality of commercial gasoline by both fixed bed and fluidized bed systems, the price and service life of catalyst and control of by-product durene must be improved. Any STG processes have not been completed yet and the yield and quality of gasoline are inferior to those of gasoline produced by the MTG process. Applying two-stage process, the STG process will be more economically effective.(21 refs, 4 figs, 10 tabs)

1987-06-20

197

An enhanced primary health care role following psychological trauma: the Christchurch earthquakes.

Topics related to aerospace power are discussed, taking into account trends and issues of military space power systems technology, space station power system advanced development, the application and use of nuclear power for future spacecraft, the current status of advanced solar array technology development, the application of a parabolic trough concentrator to space station power needs, life test results of the Intelsat-V nickel-cadmium battery, and metal hydride hydrogen storage in nickel hydrogen batteries. Other subjects explored are concerned with alternative fuels, biomass energy, biomedical power, coal gasification, electric power cycles, and electric propulsion. Attention is given to an advanced terrestrial vehicle electric propulsion systems assessment, fuel cells as electric propulsion power plants, a sinewave synthesis for high efficiency dc-ac conversion, steam desulfurization of coal, leadless transfer of energy into the body to power implanted blood pumps, oil production ...

1985-08-18

198

A Polyhydroxybutyrate Biodegradable Stent: Preliminary Experience in the Rabbit

Following the February 2011 earthquake in Christchurch, New Zealand (NZ), the authors participated in counselling local residents, and debriefing and supervising support teams. Indications were that risk for mental health disorders, including Post-Traumatic Stress Disorder (PTSD), may be elevated in residents, and that this risk may continue for some time. Patients may be de-prioritising their mental health issues when these become normalised throughout the city's population. The authors recommend that primary care patients are assessed using a brief, comprehensive tool (for example, the Case-finding and Help Assessment Tool) that targets many health and behavioural issues identified as increasing in the city following the earthquake. Anxiety and mood disorder symptoms may indicate assessment is appropriate to reduce harm arising from increased risk for PTSD. Concern also is raised for primary health care providers who may have experienced the trauma and ...

2011-09-01

199

eDNA: A Bio-Inspired Reconfigurable Hardware Cell Architecture Supporting Self-organisation and Self-healing

Purpose: The lifelong persistence of foreign bodies within the arteries may contribute to restenosis. Thus,biodegradable devices might decrease recurrence rates. Methods: Eleven polyhydroxybutyrate biodegradable stents and 13 tantalum stents were implanted into the iliac arteries of New Zealand white rabbits for up to 30 weeks. After killing the animals,the specimens were harvested, fixed in formalin, processed in paraffin,and stained. Results: Polyhydroxybutyrate instigated intense inflammatory and proliferative reactions with an increase in collagen (2.4- to 8-fold vs native segments), thrombosis and in-stentlumen narrowing (375.5-606.6 mm vs 655.6 #+-# 268.8 mm in native segments). The elastic membranes were destroyed in all specimens. The tantalum stents increased the in-stent lumen progressively (769.7 #+-# 366.6 mm vs 1309.9 #+-# 695.3 mm),penetrated the external elastic membrane, and increased mural collagen content (6- to 8.6-fold vs native segments). ...

2002-03-01

200

[Neurodevelopmental follow-up of premature children in Lausanne and Geneva].

This paper presents the concept of a biological inspired reconfigurable hardware cell architecture which supports self-organisation and self-healing. Two fundamental processes in biology, namely fertilization-to-birth and cell self-healing have inspired the development of this cell architecture. In biology as well as in our hardware cell architecture it is the DNA which enables these processes. We propose a platform based on the electronic DNA (eDNA) and show through simulation, its capabilities as a new generation of robust reconfigurable hardware platforms. We have created a Java based simulator to simulate our self-organisation and self-healing algorithms and the results obtained from this looks promising.

2009-01-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16

201

Three-Dimensional Mixed Convection Heat and Mass Transfer in a Rectangular Duct: Case of Longitudinal Rolls

Preterm children born before 32 weeks of gestation represent 1% of the annual births in Switzerland, and are the most at risk of neurodevelopmental disabilities. A neurological surveillance is thus implemented in the neonatal units, and multidisciplinary neurodevelopmental follow-up is offered to all our preterm patients. The follow-up clinics of the University hospitals in Lausanne and Geneva follow the Swiss guidelines for follow-up. An extended history and neurological examination is taken at each appointment, and a standardized test of development is performed. These examinations, which take place between the ages of 3 months and 9 years old, allow the early identification and treatment of developmental disorders frequent in this population, such as motor, cognitive or behavioral disorders, as well as the monitoring of the quality of neonatal care. PMID:21452511

2011-02-23

202

British Library Electronic Table of Contents (United Kingdom)

This article presents numerical study of 3-D thermosolutale mixed convection (TSMC) in horizontal rectangular channels. The contribution of this work is to characterize the travelling wave's appearance and to generalize the behavior of Poiseuille-Rayleigh-Benard (PRB) systems for a broad range of dimensionless parameters, which control the double diffusive mixed convection. The numerical results consist of analyzing the flow regimes of the steady longitudinal thermoconvectives rolls for the case of purely thermal mixed convection (TMC) and for both thermal and mass transfer (TSMC). The transition from opposed volume forces to cooperating ones at fixed Rayleigh (Ra), Reynolds (Re), and Lewis (Le) numbers, considerably affects the birth and the development of the longitudinal rolls (noted R/...

2011-01-01

203

Scoring of brain maturation in developmentally handicapped children with high-field MR imaging

Prenatal diagnosis and perinatal management of left coronary artery to right atrium fistula.

A four-stage scoring system for brain maturation was established with MR imaging. First, gyration and myelination were analyzed in 50 anamnestically normal children (32-240 weeks postconceptional age). Subsequently 60 patients (same age range) with birth asphyxia, seizures, or developmental delays were evaluated analogously. T1- and T2-weighted images (500/30 and 3,000/120 [repetition time msec/echo time msec]) were obtained with a 2.35-T magnet in all children. Whereas gyration abnormalities were seen in some patients, all handicapped children presented with delayed myelination. In conclusion, prospective staging of brain development (gyration and myelination) is possible and is best obtained with T2-weighted images.

204

Hemidiaphragmatic paralysis in preterm neonates: a rare complication of peripherally inserted central catheter extravasation

Serious complications due to coronary artery fistulae have been described. Most authors recommend early intervention at the time of diagnosis. We present a case of a fistula originating from a dilated left coronary artery and draining into the right atrium, which was diagnosed prenatally by color Doppler echocardiography. During pregnancy, the echocardiographic findings remained unchanged, and there were no signs of heart failure. After birth, the fistula was confirmed by angiography. Additionally, a persistent left superior vena cava draining into the coronary sinus and a very small ventricular septal defect were detected. The fistula was closed successfully by transcatheter coil embolization. At 17 months old the child was in good clinical condition. Prenatal diagnosis of coronary artery fistulae may be possible and may improve perinatal management and outcome. PMID:12047543

2002-06-01

205

British Library Electronic Table of Contents (United Kingdom)

Unilateral diaphragmatic paralysis was diagnosed in 2 preterm neonates born at 29 and 25 weeks of gestation, respectively. In both instances, the pathophysiology was phrenic nerve injury after extravasation of parenteral nutrition fluid. Misplacement and infection were predisposing factors. Diaphragmatic movement analysis by time-motion-mode ultrasonography was helpful in achieving a diagnosis. The first neonate required a diaphragmatic placation, whereas the other infant was managed nonoperatively. These cases confirm a rare etiology of diaphragmatic paralysis and possible spontaneous recovery. In neonates with very low birth weight, general anesthesia and thoracic surgery may be associated with a high morbidity, suggesting that nonoperative medical treatment, when possible, is preferable...

2011-01-01

206

Gas and steam turbines: Power from fire; Gas- und Dampfturbinen: Kraft aus dem Feuer

Early Language Learning and Literacy: Neuroscience Implications for Education

More than 200 years after the birth of the steam engine, the first thermal engine ever invented, thermal engines such as steam turbines, gas turbines or internal combustion engines are still driving most generators for electric power generation, most machines, and most vehicles, and this will remain so until far into the next century. (orig.) [Deutsch] Mit Waermekraftmaschinen wie Dampfturbinen, Gasturinen und Verbrennungsmotoren werden auch heute - mehr als 200 Jahre nach der technischen Reife der Dampfmaschine (der ersten Waermekraftmaschine) - die meisten Generatoren zur Stromerzeugung, die meisten Arbeitsmaschinen und die meisten Fahrzeuge angetrieben. Und dabei wird es auch bis weit in das 21. Jahrhundert bleiben. (orig.)

1996-02-01

207

British Library Electronic Table of Contents (United Kingdom)

The last decade has produced an explosion in neuroscience research examining young children's early processing of language that has implications for education. Noninvasive, safe functional brain measurements have now been proven feasible for use with children starting at birth. In the arena of language, the neural signatures of learning can be documented at a remarkably early point in development, and these early measures predict performance in children's language and pre-reading abilities in the second, third, and fifth year of life, a finding with theoretical and educational import. There is evidence that children's early mastery of language requires learning in a social context, and this finding also has important implications for education. Evidence relating socioeconomic status (SES) ...

2011-01-01

208

Dating Studies of Elephant Tusks Using Accelerator Mass Spectrometry

Cardiac Channelopathies and Sudden Infant Death Syndrome

A new method for determining the year of birth, the year of death, and hence, the age at death, of post-bomb and recently deceased elephants has been developed. The technique is based on Accelerator Mass Spectrometry radiocarbon analyses of small-sized samples extracted from along the length of a ge-line of an elephant tusk. The measured radiocarbon concentrations in the samples from a tusk can be compared to the {sup 14}C atmospheric bomb-pulse curve to derive the growth years of the initial and final samples from the tusk. Initial data from the application of this method to two tusks will be presented. Potentially, the method may play a significant role in wildlife management practices of African national parks. Additionally, the method may contribute to the underpinnings of efforts to define new international trade regulations, which could, in effect, decrease poaching and the killing of very young animals.

2002-10-03

209

British Library Electronic Table of Contents (United Kingdom)

Abstract Sudden infant death syndrome (SIDS) is always a devastating and unexpected occurrence. SIDS is the leading cause of death in the first 6 months after birth in the industrialized world. Since the discovery in 1998 of long QT syndrome as an underlying substrate for SIDS, around 10-20% of SIDS cases have been proposed as being caused by genetic variants in either ion channel or ion channel-associated proteins. Until now, 10 cardiac channelopathy susceptibility genes have been found to be implicated in the pathogenesis of SIDS. Four of the genes encode cardiac ion channel a-subunits, 3 genes encode ion channel b-subunits, and 3 genes encode other channel-interacting proteins. All 10 genes have been associated with primary electrical heart diseases. SIDS may hereby be the initial sympt...

2011-01-01

210

Bifurcation and chaos of a pest-control food chain model with impulsive effects

A cosmological "probability event horizon" and its observational implications

According to biological and chemical control strategy for pest control, we investigate the dynamics of a predator-prey food chain with impulsive effect, periodic releasing natural enemies and spraying pesticide at different fixed times, by using impulsive differential equation. Choose pest birth rate r{sub 2} as control parameter, we show that there exists a stable pest-eradication periodic solution when r{sub 2} is less than some critical value r{sub 2}* and the system is permanence when r{sub 2} is larger than the critical value r{sub 2}*. By use of standard techniques of bifurcation theory, we prove that above this threshold there are periodic oscillations in prey, middle-predator and top predator. Furthermore, bifurcation diagrams have shown that there exists complexity for the pulsed system including periodic doubling cascade.

2009-02-28

211

Uranium-lead zircon ages from the Median Tectonic Zone, New Zealand

Suppose an astronomer is equipped with a device capable of detecting emissions -- whether they be electromagnetic, gravitational, or neutrino -- from transient sources distributed throughout the cosmos. Because of source rate density evolution and variation of cosmological volume elements, the sources first detected when the machine is switched on are likely to be ones in the high-redshift universe; as observation time increases, rarer, more local, events will be found. We characterize the observer's evolving record of events in terms of a "probability event horizon", converging on the observer from great distances at enormous speed, and illustrate it by simulating neutron star birth events distributed throughout the cosmos. As an initial application of the concept, we determine the approach of this horizon for gamma-ray bursts (GRBs) by fitting to redshift data. The event rates required to fit the model are consistent with the proposed link between core-collapse ...

2005-01-01

212

IEA Statistics 1993: electricity information

The Median Tectonic Zone (MTZ) of New Zealand is a generally north trending belt of Mesozoic subduction related I-type plutonic, volcanic, and sedimentary rocks in South Island and Stewart Island that separates Permian strata of the Eastern Province Brook Street Terrane from lower to mid Gondwana margin assemblages of the Western Province. High precision isotope dilution U/Pb ages of zircons from 30 rocks are reported. Pre-digestion leaching of zircon in hydrofluoric acid yielded significantly more concordant residues by removing common Pb and dissolving more soluble high-U domains that have been more affected by relatively recent Pb loss. The results show that MTZ magmatism ranges in age from at least Early Triassic to Early Cretaceous (247-131 Ma), with a pronounced gap in the Middle Jurassic. Triassic plutons tend to occur on the eastern side of the MTZ, and they intrude volcanic/sedimentary sequences of the MTZ in Nelson and eastern Fiordland. These sequences ...

213

Usefulness of routine laboratory parameters in the decision to treat refractory cardiac arrest with extracorporeal life support

Gross electricity production in 1993 in the OECD (including generation from pumped storage plants) was 7 466 TWh, a rise of 1.2 per cent from the level of gross production in 1992 (Tables 1 and 3). Nuclear plants accounted for 24.2 per cent of total gross electricity production in 1993, hydroelectric plants 16.7 per cent, total thermal plants 58.7 per cent and geothermal and other renewables 0.4 per cent. In 1992 total OECD heat production that is sold to third parties by public producers was 25 Mtoe (Table 6). About 86 per cent of this heat (21.6 Mtoe) was produced in CHP plants, about 12 per cent (3.1 Mtoe) in heat plants, and the remainder (0.3 Mtoe) in nuclear power plants (in Canada and Switzerland only). Based on preliminary data, apparent consumption of electricity (gross production plus imports less exports) in 1993 in OECD was 7 474 TWh. The corresponding figure for 1992 was 7 379 TWh, indicating a rise of 1.3 per cent in apparent electricity consumption in OECD countries in ...

1993-01-01

214

British Library Electronic Table of Contents (United Kingdom)

Aim: To evaluate the usefulness of routine laboratory parameters in the decision to treat refractory cardiac arrest patients with extracorporeal life support (ECLS). Methods: Sixty-six adults with witnessed cardiac arrest of cardiac origin unrelated to poisoning or hypothermia undergoing cardiopulmonary resuscitation without return of spontaneous circulation (duration: 155min [120-180], median, [25-75%-percentiles]) were included in a prospective cohort-study. ECLS was implemented under cardiac massage, using a centrifugal pump connected to a hollow-fiber membrane-oxygenator, aiming to maintain ECLS flow >=2.5l/min and mean arterial pressure >=60mmHg. Results: Forty-seven of 66 patients died within 24h from multiorgan failure and massive capillary leak. Of 19/66 patients who survived >=24h...

2011-01-01

215

Toll-like receptor 2 polymorphism and gram-positive bacterial infections after liver transplantation

British Library Electronic Table of Contents (United Kingdom)

Abstract Toll-like receptor 2 (TLR2) is an immune sensor for gram-positive bacterial cell wall components. Single-nucleotide polymorphisms (SNPs) in the TLR2 gene that impair its function may, therefore, influence the risk and outcomes of gram-positive bacterial infections. In a cohort of 694 liver transplant recipients, we assessed the TLR2 SNP that is translated into an amino acid substitution of arginine for glutamine at position 753 (R753Q), and we found that its presence was associated with the clinical characteristics and outcomes of gram-positive bacterial infections. The proportions of patients with the TLR2 R753Q SNP did not significantly differ between those with gram-positive bacterial infections and those without gram-positive bacterial infections (9.6% versus 9.6%, P = 0.999)....

2011-01-01

216

The Physical and Mental Health of Australian Vietnam Veterans 3 Decades After the War and Its Relation to Military Service, Combat, and Post-Traumatic Stress Disorder

British Library Electronic Table of Contents (United Kingdom)

The long-term health consequences of war service remain unclear, despite burgeoning scientific interest. A longitudinal cohort study of a random sample of Australian Vietnam veterans was designed to assess veterans' postwar physical and mental health 36 years after the war (2005-2006) and to examine its relation to Army service, combat, and post-traumatic stress disorder (PTSD) assessed 14 years previously (1990-1993). Prevalences in veterans (n = 450) were compared with those in the Australian general population. Veterans' Army service and data from the first assessments were evaluated using multivariate logistic regression prediction modeling. Veterans' general health and some health risk factors were poorer and medical consultation rates were higher than Australian population expectatio...

2009-01-01

217

Soy isoflavones, diet and physical exercise modify serum cytokines in healthy obese postmenopausal women

British Library Electronic Table of Contents (United Kingdom)

Objectives: Evaluate the effect of diet, physical exercise, and a daily oral intake of a soy isoflavones extract (Fisiogen) contained 200mg of Glycine max, which corresponded to 80mg of isoflavone (60.8mg of genistein, 16mg of daidzein and 3.2mg of glicitein) on leptin and other adipokines plasma levels in healthy obese postmenopausal women. Methods: A multicentric randomized longitudinal prospective cohort study was conducted in a sample of 87 healthy obese postmenopausal women. Patients were randomly assigned to a 1200kcal diet and exercise group (control group) or a group of 1200kcal diet, exercise, and daily oral intake of daily oral intake of a soy isoflavones extract (Fisiogen) contained 200mg of Glycine max, which corresponded to 80mg of isoflavone (60.8mg of genistein, 16mg of daid...

2011-01-01

218

Relationship of blood lead to blood pressure in a longitudinal study of working men

Reduction in incidence of deep sternal wound infections: Random or real?

The relationship of lead exposure to blood pressure has been examined in a longitudinal study of a cohort of 89 Boston, Massachusetts, policemen. At the baseline examination, subjects had a blood lead determination and three consecutive blood pressure measurements. Triplicate blood pressure measurements were also taken at years 3, 4, and 5. Multivariate analysis revealed that, after correction for previous systolic blood pressure, body mass index, age, and smoking, a high level of blood lead was a significant predictor of subsequent elevation of systolic pressure. Bootstrap simulations of these models provided supporting evidence for the observed associations. These data suggest that lead exposure can significantly affect systolic pressure.

1986-05-01

219

British Library Electronic Table of Contents (United Kingdom)

Objective Comorbidities predisposing cardiac surgical patients toward deep sternal wound infection, such as diabetes and obesity, are rising in the United States. Longitudinal analysis of risk factors, morbidity, and mortality was performed to assessed effects of these health trends on deep sternal wound infection rates. Methods In this retrospective analysis of all median sternotomies performed at a single institution from 1991 through 2006, demographic and surgical characteristics were identified from a prospective database. The cohort was separated into periods from 1992 through 2001 and 2002 through 2006 to identify longitudinal trends in risk factors for deep sternal wound infection. Univariate and matched multivariable analyses were performed. Results Overall, study population had in...

2010-01-01

220

Plasma carotenoids and risk of acute myocardial infarction in the Singapore Chinese Health Study

British Library Electronic Table of Contents (United Kingdom)

Background and aimModification of low-density lipoprotein due to oxidative stress is essential in the development of coronary atherosclerosis. Data of specific carotenoids except b-carotene on cardioprotective effects in humans are limited. Methods and resultsThis study examined the associations between plasma concentrations of specific carotenoids and incidence of acute myocardial infarction. The study included 280 incident cases of acute myocardial infarction and 560 matched controls nested within the Singapore Chinese Health Study, a prospective cohort of 63,257 Chinese men and women aged 45-74 years old enrolled in 1993-1998 in Singapore. Retinol and carotenoids in prediagnostic plasma were quantified using high-performance liquid chromatography. High levels of plasma b-cryptoxanthin a...

2011-01-01

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221

Perception of anesthesia safety and postoperative symptoms of surgery patients in Ho Chi Minh City, Vietnam: a pioneering trial of postoperative care assessment in a developing nation

British Library Electronic Table of Contents (United Kingdom)

Objectives Vietnamese patients? views on healthcare are changing as surgical interventions become more commonplace, but their views on perioperative care have remained largely unstudied during this period of rapid change. This study assesses Vietnamese patients? impression of anesthesia safety and postoperative pain in relation to clinical outcomes with the aim of improving patient-centered perioperative care. Methods The study cohort consisted of 180 hospitalized patients who were followed for 24?h following abdominal surgery. The assessments of these patients on the use of anesthesia and postoperative pain were measured by means of a 5-point Likert scale survey. Perioperative events were recorded on standardized forms by medical staff. The relationship between relevant factors affecting ...

2010-01-01

222

Outcomes of extremely low risk prostate cancer following radical prostatectomy

British Library Electronic Table of Contents (United Kingdom)

The optimal management of men with very favorable clinicopathological factors who develop biochemical recurrence (BCR) after radical prostatectomy (RP) has not been previously reported. Both local and systemic recurrences are unlikely in this cohort. This study examines their management and outcomes. Between October 2000 to March 2010, 1627 men underwent open RP by a single surgeon. In all, 448 (27.5%) met the following criteria for extremely low risk disease: preoperative PSA level <10?ng?ml?1, clinical stage T1c/T2a, Gleason score ?6, estimated cancer volume in the surgical specimen ?5% and no evidence for positive surgical margin. Undetectable PSA was defined as ?0.04?ng?ml?1. BCR was defined as PSA ?0.2?ng?ml&#...

2011-01-01

223

Onset of epilepsy and menarche-Is there any relationship?

British Library Electronic Table of Contents (United Kingdom)

SummaryPurposeWomen with epilepsy have increased frequency of reproductive health problems compared to women without epilepsy. In puberty, reproductive hormonal changes during sexual maturation may affect epilepsy and induce the debut of seizures as indicated in some studies. On the other hand, epileptic activity affects sex hormone function, which may induce alterations in pubertal endocrine maturation and thereby menarche age. We wanted to investigate the relation between epilepsy and menarche age in a larger population of female epilepsy patients.MethodsA retrospective, questionnaire study of a cohort of 265 female outpatients from three Norwegian hospitals and 142 controls, aged 18-45 years was conducted. Parameters regarding epilepsy and reproductive health issues were registered. Per...

2006-01-01

224

One-year prospective follow-up of pharmacological treatment in children with attention-deficit/hyperactivity disorder

British Library Electronic Table of Contents (United Kingdom)

Objectives To delineate the safety and tolerability profile of methylphenidate and atomoxetine in children and adolescents with attention deficit hyperactivity disorder (ADHD) monitored for more than 1?year. Design A cohort study analyzing data from the national ADHD register on patients from the Lombardy Region treated with MPH or atomoxetine. Participants A total of 229 children (median age 11?years, range 6?17), enrolled in 15 regional centers between June 2007 and May 2010. Results The prevalence rate of pharmacological treatment for ADHD was 0.23%, whereas the estimated ADHD prevalence in the population was 0.95%. In total, 73.8% of patients had been treated with atomoxetine (10?90?mg daily) or MPH (10?75?mg daily); 22% of patients also received an additional psychotropic drug. Of the...

2011-01-01

225

No detectable XMRV in subjects with chronic fatigue syndrome from Quebec

British Library Electronic Table of Contents (United Kingdom)

We investigated the presence of XMRV in a cohort of Quebec patients with chronic fatigue syndrome (CFS). DNA was purified from activated peripheral blood mononuclear cells (PBMCs) and PCR was used to detect XMRV gag and env in 72 patients. Anti-XMRV antibodies were searched in sera of 62 patients by Western blot analysis. Attempts to detect XMRV antigens was made, using immunofluorescence with Gag anti-p30 antiserum on activated PBMC from 50 patients. Plasma viremia was measured by RT-PCR on 9 subjects. Finally, detection of infectious virus in 113 CFS subjects was made by co-culture of PHA+IL-2 activated PBMC with human LNCaP carcinoma cells, and by infecting the same susceptible cells with plasma, using a reverse transcriptase (RT) assay as a readout in both experiments. No detection of ...

2011-01-01

226

Infant well-being following neonatal cardiac surgery

British Library Electronic Table of Contents (United Kingdom)

Aims and objectives.- To investigate infant well-being as measured by feeding and sleeping and parental support following discharge from the NICU in infants following major cardiac surgery. Background.- Infant feeding and sleeping have been identified as two of the most important concerns reported by parents. These concerns have been reported anecdotally for infants who have undergone cardiac surgery in the neonatal period. Design.- A prospective study using questionnaires and phone interviews followed a cohort of parents of neonates who underwent surgery in the neonatal period for congenital heart disease. Methods.- The study was conducted using validated questionnaires and phone interviews with a semi-structured questionnaire. The questionnaires were administered prior to discharge from ...

2011-01-01

227

Health effects

Functional and Oncologic Outcomes of Partial Adrenalectomy for Pheochromocytoma in Patients With von Hippel-Lindau Syndrome After at Least 5 Years of Followup

The main objectives of research in the field of health effects at the Belgian Nuclear Research Centre SCK-CEN are: (1) to study cancer mortality and morbidity in nuclear workers in Belgium; (2) to document the feasibility of retrospective cohort studies in Belgium; (3) to participate in the IARC study; (4) to elucidate the mechanisms of the effects of ionizing radiation on the mammalian embryo during the early phases of its development; (5) to assess the genetic risks of material exposure to ionizing radiation; (6) to elucidate the cellular mechanisms leading to brain damage after prenatal irradiation; (7) to advise authorities and to provide the general population with adequate information concerning the health risk arising from radiation exposure. Progress and major achievements in these topical areas for 1997 are reported.

228

British Library Electronic Table of Contents (United Kingdom)

PurposeAlthough the safety and feasibility of partial adrenalectomy in patients with von Hippel-Lindau syndrome have been established, long-term outcomes have not been examined. In this study we evaluate the recurrence and functional outcomes in a von Hippel-Lindau syndrome cohort treated for pheochromocytoma with partial adrenalectomy with a followup of at least 5 years. Materials and MethodsWe reviewed the records of patients with von Hippel-Lindau syndrome treated with partial adrenalectomy for pheochromocytoma at the National Cancer Institute. Demographic, germline mutation status, surgical indication, oncologic and functional outcome data were collected. Local recurrence was defined as radiographic evidence of recurrent tumor on the ipsilateral side of partial adrenalectomy. Patients ...

2010-01-01

229

Evaluation of cost effectiveness for conservative and active management strategies for acoustic neuroma

British Library Electronic Table of Contents (United Kingdom)

Clin. Otolaryngol. 2009, 34, 438-446. Objective: To determine whether economic costs associated with a conservative management strategy for unilateral acoustic neuroma offer an economic advantage over active management options. Design: Cost and sensitivity analysis on a prospective cohort. Setting: Single centre study within a tertiary referral centre in Toronto, Canada. Participants: 72 patients (32 males, 40 females) aged 36 to 78 years with unilateral acoustic neuroma were assigned initially to a conservative management strategy. Entry criteria were small tumour size (less than 15mm in the cerebellopontine angle), patient preference and/or significant co-morbidity. Interventions: MRI scanning was performed every 6 months for the first year, annually subsequently and then every 2-3 years...

2009-01-01

230

Estimating personal costs incurred by a woman participating in mammography screening in the National Breast and Cervical Cancer Early Detection Program

British Library Electronic Table of Contents (United Kingdom)

BACKGROUND.The National Breast and Cervical Cancer Early Detection Program (NBCCEDP) covers the direct clinical costs of breast and cervical cancer screening and diagnostic follow-up for medically underserved, low-income women. Personal costs are not covered. In this report, the authors estimated personal costs per woman participating in NBCCEDP mammography screening by race/ethnicity and also estimated lifetime personal costs (ages 50-74 years).METHODS.A decision analysis model was constructed and parameterized by using empiric data from a retrospective cohort survey of mammography rescreening among women ages 50 years to 64 years who participated in the NBCCEDP. Data from 1870 women were collected from 1999 to 2000. The model simulated the flow of resources incurred by a woman participat...

2008-01-01

231

Energy-based hemostatic devices in laparoscopic adrenalectomy

British Library Electronic Table of Contents (United Kingdom)

Purpose In literature, few papers compare different hemostatic devices in laparoscopic adrenalectomy. This sequential cohort study analyzes the outcomes of laparoscopic adrenalectomy performed by different hemostatic instruments, to evaluate if any of them has any advantage over the other and as secondary endpoints, the impact of body mass index (BMI) and tumor size on the indication, and the outcome of laparoscopic adrenalectomy. Methods Forty-six patients, aged 54.6???46?years, underwent laparoscopic adrenalectomy over 5?years. Mean BMI was 27???4.8?kg/m2. Twenty-four patients had a left tumor, and 22 had a right one. Patients were divided into two groups according to the hemostatic device: Ultracision was used in 26 patients, and Ligasure was used in 20. Groups were well matched for his...

2010-01-01

232

Efficacy and safety of certolizumab pegol in an unselected crohn's disease population: 26-week data of the FACTS II survey

British Library Electronic Table of Contents (United Kingdom)

AbstractBackground: Certolizumab pegol (Cimzia, CZP) was approved for the treatment of Crohn's disease (CD) patients in 2007 in Switzerland as the first country worldwide. This prospective phase IV study aimed to evaluate the efficacy and safety of CZP over 26 weeks in a multicenter cohort of practice-based patients. Methods: Evaluation questionnaires at baseline, week 6, and week 26 were completed by gastroenterologists in hospitals and private practices. Adverse events were evaluated according to World Health Organization (WHO) guidelines. Results: Sixty patients (38F/22M) were included; 53% had complicated disease (stricturing or penetrating), 45% had undergone prior CD-related surgery. All patients had prior exposure to systemic steroids, 96% to immunomodulators, 73% to infliximab, and...

2011-01-01

233

Consumption of filtered and boiled coffee and the risk of incident cancer: a prospective cohort study

British Library Electronic Table of Contents (United Kingdom)

Background Despite potentially relevant chemical differences between filtered and boiled coffee, this study is the first to investigate consumption in relation to the risk of incident cancer. Methods Subjects were from the V?sterbotten Intervention Project (64,603 participants, including 3,034 cases), with up to 15?years of follow-up. Hazard ratios (HR) were calculated by multivariate Cox regression. Results No associations were found for all cancer sites combined, or for prostate or colorectal cancer. For breast cancer, boiled coffee ?4 versus <1 occasions/day was associated with a reduced risk (HR?=?0.52, CI?=?0.30?0.88, p trend?=?0.247). An increased risk of premenopausal and a reduced risk of postmenopausal breast cancer were found for both total (HRpremenopausal?=?1.69, CI?=?0.96?2.98...

2010-01-01

234

Comparison of Effectiveness and Safety of Ranolazine Versus Amiodarone for Preventing Atrial Fibrillation After Coronary Artery Bypass Grafting

British Library Electronic Table of Contents (United Kingdom)

Atrial fibrillation (AF) is common after coronary artery bypass grafting (CABG) and increases the morbidity and cost. Amiodarone reduces AF after CABG. Ranolazine, an antianginal agent, also prolongs atrial refractoriness and inhibits after depolarizations and triggered activity; effects that could decrease AF after CABG. The present study compared amiodarone versus ranolazine for the prevention of AF after CABG. A retrospective cohort study of patients undergoing CABG at Aspirus Hospital from June 2008 to April 2010. The patients received either amiodarone (400 mg preoperatively followed by 200 mg twice daily for 10 to 14 days) or ranolazine (1,500 mg preoperatively followed by 1,000 mg twice daily for 10 to 14 days). The primary end point was any identified AF after CABG. A total of 393 ...

2011-01-01

235

Clinical and metabolic characteristics of polycystic ovary syndrome without polycystic ovary: a pilot study on Chinese women

British Library Electronic Table of Contents (United Kingdom)

Objective To demonstrate clinical features of a patient subgroup presenting with polycystic ovary syndrome (PCOS) without polycystic ovary morphology. Design Retrospective study. Setting Hospital-based IVF center. Patient(s) In the present study, 876 PCOS patients were selected from women who visited the Reproductive Medicine Center at Shandong Provincial Hospital, Shandong University, between September 2004 and October 2006. Women with PCOS were divided into two groups based on ultrasound image: group A, PCOS patients with classic polycystic ovary (n = 800); group B, PCOS patients without polycystic ovary morphology (n = 76). The following available data were analyzed in the large cohort of women: body height, weight, waistline, hip circumference, hirsutism scores, family history, serum s...

2008-01-01

236

Clinical Characteristics of Children Receiving Antipsychotic Medication

British Library Electronic Table of Contents (United Kingdom)

Abstract This study explored the demographic and diagnostic features of children who were currently receiving antipsychotics compared to children who were receiving other psychotropics in a cohort of children with and without elevated symptoms of mania (ESM). Participants were recruited from 10 child outpatient mental health clinics associated with four universities. Guardians with children between 6?12 years who presented for new clinical evaluations completed the Parent General Behavior Inventory-10 Item Mania Scale (PGBI-10M). All children who scored ?12 on the PGBI-10M and a select demographically matched comparison group of patients who scored ?11 were invited to participate. Children were divided into two groups: those receiving at least one antipsychotic medication and those receivi...

2011-01-01

237

Chromosomal mapping of excessive physical activity in mice in response to a restricted feeding schedule

British Library Electronic Table of Contents (United Kingdom)

Excessive physical activity plays an important role in the progression of anorexia nervosa (AN) by accelerating weight loss during dietary restriction. To search for mechanisms underlying this trait, a panel of mouse chromosome substitution strains derived from C57BL/6J and A/J strains was exposed to a scheduled feeding paradigm and to voluntary running wheel (RW) access. Here, we showed that A/J chromosomes 4, 12 and 13 contribute to the development of a disrupted RW activity in response to daily restricted feeding. This pattern is characterized by intense RW activity during the habitual rest phase and leads to accelerated body weight loss. Regions on mouse chromosomes 4, 12 and 13 display homology with regions on human chromosomes linked with anxiety and obsessionality in AN cohorts. The...

2010-01-01

238

Aspirin Use Is Associated With an Improved Long-Term Survival in an Unselected Population Presenting With Unstable Angina

British Library Electronic Table of Contents (United Kingdom)

AbstractBackground Few published data are available on the benefits of aspirin use in patients with unstable angina (UA). Hypothesis Aspirin use carries a mortality benefit in a population-based cohort of patients presenting with UA. Methods All residents of Olmsted County, Minnesota presenting to local emergency departments with acute chest pain from January 1985 through December 1992 having symptoms consistent with UA were identified through medical records. A total of 1628 patients were identified with UA and were stratified by aspirin use in-hospital and at discharge. Cardiovascular mortality and nonfatal myocardial infarction and stroke were assessed over a median of 7.5 years follow-up and all-cause mortality data over a median of 16.7 years. The mean age of patients with UA was 65 y...

2010-01-01

239

A comparative assessment of the RIFLE, AKIN and conventional criteria for acute kidney injury after hematopoietic SCT

British Library Electronic Table of Contents (United Kingdom)

An observational cohort study was conducted to compare the performance of the RIFLE (risk, injury, failure, loss and end-stage kidney disease), AKIN (acute kidney injury network) and conventional graded criteria to identify acute kidney injury (AKI) following SCT and to predict long-term mortality in 141 myeloablative allogeneic SCT (m-allo), 60 non-myeloablative allogeneic SCT (nm-allo) and 48 autologous SCT (auto) cases. The AKIN criteria had less ability to identify patients as having the lowest category, stage 1 (analogous to RIFLE risk): 33% (37%) in m-allo, 23% (32%) in nm-allo and 8.3% (16.7%) in auto. Cox regression showed that categories higher than the intermediate stage were independent predictors of mortality in all three definitions. The areas under receiver operating characte...

2010-01-01

240

A cementless elastic monoblock socket in young patients: a ten to 18-year clinical and radiological follow-up

British Library Electronic Table of Contents (United Kingdom)

The survival of acetabular components depends on several factors: wear, osteolysis and septic or aseptic loosening. Osteolysis seems to be the main cause for concern in cementless arthroplasties. Acetabular osteolysis results from particle debris and segmental unloading of acetabular bone by rigid sockets. We investigated a cementless elastic monoblock socket with regard to acetabular osteolysis and aseptic loosening in a cohort of young patients. We evaluated 158 hip arthroplasties with a minimum follow-up of ten?years (ten to 18) and a mean age of 42?years (18?50). The overall revision rate at 14?years was 80% with a 98% survival rate for aseptic loosening. The mean polyethylene wear rate was 0.11?mm/year. Progressive acetabular osteolysis was seen in 3% of patients evaluated. In conclus...

2011-01-01

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241

Sudden infant death syndrome and placental disorders: the thyroid-selenium link.

Vitamins B2 and B6 and genetic polymorphisms related to one-carbon metabolism as risk factors for gastric adenocarcinoma in the European prospective investigation into cancer and nutrition

Placental insufficiency, inducing hypoxia-ischaemia, is considered a major cause of neuronal injury and impaired post natal development. Placental insufficiency alters the metabolism of arachidonic acid and its oxidation products. Premature labour and low-birth-weight infants are associated with reduced intrauterine blood-flow and infections of the reproductive tract. Thyroidal activity is depressed in undernutrition (placental insufficiency). Premature infants require extra vitamin C for normal tyrosine metabolism (tyrosine is the thyroxine precursor). Among the symptoms indicating infantile cretinism, which appear during 3-5 months of age are: delayed union of skull bones, torpid behaviour, slow feeding, cyanosis during feeding, excessive sleepiness, enlarged tongue, umbilical herniation, flabby musculature, short stature and delayed development. These symptoms have all been described in low-birth-weight infants and sudden infant death ...

1997-04-01

242

Technical Basis Document: A Statistical Basis for Interpreting Urinary Excretion of Plutonium Based on Accelerator Mass Spectrometry (AMS) for Selected Atoll Populations in the Marshall Islands

B vitamins and polymorphisms in genes coding for enzymes involved in one-carbon metabolism may affect DNA synthesis and methylation and thereby be implicated in carcinogenesis. Previous data on vitamins B2 and B6 and genetic polymorphisms other than those involving MTHFR as risk factors for gastric cancer (GC) are sparse and inconsistent. In this case-control study nested within the European Prospective Investigation into Cancer and Nutrition cohort, cases (n = 235) and controls (n = 601) were matched for study center, age, sex, and time of blood sampling. B2 and B6 species were measured in plasma, and the sum of riboflavin and flavin mononucleotide was used as the main exposure variable for vitamin B2 status, whereas the sum of pyridoxal 5'-phosphate, pyridoxal, and 4-pyridoxic acid was used to define vitamin B6 status. In addition, we determined eight polymorphisms related to one-carbon metabolism. Relative risks for GC risk were calculated with conditional ...

2010-01-01

243

We have developed refined statistical and modeling techniques to assess low-level uptake and urinary excretion of plutonium from different population group in the northern Marshall Islands. Urinary excretion rates of plutonium from the resident population on Enewetak Atoll and from resettlement workers living on Rongelap Atoll range from <1 to 8 {micro}Bq per day and are well below action levels established under the latest Department regulation 10 CFR 835 in the United States for in vitro bioassay monitoring of {sup 239}Pu. However, our statistical analyses show that urinary excretion of plutonium-239 ({sup 239}Pu) from both cohort groups is significantly positively associated with volunteer age, especially for the resident population living on Enewetak Atoll. Urinary excretion of {sup 239}Pu from the Enewetak cohort was also found to be positively associated with estimates of cumulative exposure to worldwide fallout. Consequently, the ...

2007-05-01

244

Anemia and growth status in pediatric patients receiving maintenance dialysis after a failed renal transplant course: an NAPRTCS report.

Purpose: To conduct a retrospective analysis within a large university teaching hospital, comparing outcomes between patients receiving either radical surgery or radiotherapy as curative treatment for bladder cancer. Patients and Methods: Between March 1996 and December 2000, 169 patients were treated radically for muscle-invasive bladder cancer. Data were collected from patient notes. Statistical analyses were performed using Kaplan-Meier methods and Cox proportional hazards regression analysis to compare radiotherapy and surgical outcome data. Results: There was no difference in overall, cause-specific, and distant recurrence-free survival at 5 years between the two groups, despite the radiotherapy group being older (median age, 75.3 years vs. 68.2 years). There were 31 local bladder recurrences in the radiotherapy group (24 solitary), but there was no significant difference in distant recurrence-free survival. In a more recent (2002-2006) cohort, the median age ...

2008-02-01

245

Suppression of pitting corrosion with passive film modification on type 304 stainless steel by ultra-violet light irradiation; Shigaikoshosha ni yoru Type 304 stainless ko no fudotai himaku kaishitsu to koshoku yokusei

We conducted a retrospective review of the North American Renal Transplant Cooperative Study (NAPRTCS) Registry transplant and dialysis arms to assess anemia and growth patterns in children who returned to dialysis after a failed renal transplant from January 1, 1992 to February 3, 2004. Of the 1807 potential study subjects, 1451 had transplant removal data (TxIn vs. TxOut) available for analysis. Four hundred and twenty-one of 1451 patients (29%) had a transplant nephrectomy at the time of entry into the NAPRTCS Registry Dialysis arm. Anemia rates steadily decreased from 72.2% at 30 days after dialysis initiation to 59.5% at 12 months after dialysis initiation. Factors associated with anemia at 30 days after dialysis initiation included hemodialysis, lack of Epo use, and patients who comprised earlier study era cohorts. At one yr after return to dialysis, earlier study cohort era was the only factor associated with anemia status. Patients did ...

2007-03-01

246

Stripping a debris disk by close stellar encounters in an open stellar cluster

In this study, the effects of 325nm wavelength ultraviolet light irradiation on pitting corrosion behavior of type 340 stainless steel in a neutral chloride solution are studied. Further, the change of passive film with the light irradiation is analyzed using x-ray photoelectron spectroscopy. The mains results obtained therefrom are stated below. Pitting potential can be shifted in noble direction by the ultraviolet light irradiation. The effect of ultraviolet light irradiation is ore prominent in the pitting corrosion process than that in the passive film formation. The result of the analysis in terms of the birth and death stochastic probability process shows that pitting corrosion rate is decreased remarkably by the ultraviolet light irradiation at the formation of passive film, while the repassivation is slightly expedited by the ultraviolet light irradiation. On the other hand, the repassivation rate is increased a little by the ultraviolet light irradiation ...

1998-06-20

247

Stable isotope studies on iron bio-availability in young Indian women: Effects of nutritional status, interactions and ethnicity

A debris disk is a constituent of any planetary system surrounding a main sequence star. We study whether close stellar encounters can disrupt and strip a debris disk of its planetesimals in the expanding open cluster of its birth. Such stripping would affect the dust production and hence detectability of the disk. We tabulated the fractions of planetesimals stripped off during stellar flybys of miss distances between 100 and 1000 AU and for several mass ratios of the central to passing stars. We then estimated the numbers of close stellar encounters over the lifetime of several expanding open clusters characterized by their initial star densities. We found that a standard disk, with inner and outer radii of 40 and 100 AU, suffers no loss of planetesimals around a star born in a common embedded cluster with star density 20 000 pc^-3. In this environment, a disk loses >97% of its planetesimals around an M-dwarf, >63% around a solar-type star, and >42% ...

2011-01-01

248

Species abundance distributions in neutral models with immigration or mutation and general lifetimes

Iron is an essential micronutrient. As an integral part of hemoglobin, it is essential for the transport of oxygen in blood to the tissues. It is an important component of cytochromes and other tissue enzymes that are critical for cellular respiration and of myoglobin that helps maintain oxygen reserve in the muscle. It is also involved in the normal functioning of the immune function, and in the synthesis of steroid hormones and bile acids. There are serious functional consequences to iron deficiency and iron deficiency anemia (IDA) in the human body. The deleterious effects include increased morbidity, preterm delivery, low birth weight, delayed cognitive development, lowered cellular immunity and reduced physical work capacity. However, iron deficiency and IDA remain the world's most common deficiency disease in the 21st century. Recent estimates of people affected with iron deficiency and IDA are 3.5 billion. Iron deficiency anemia is most prevalent and severe ...

2002-06-24

249

Some considerations on the processes of axon bundling and the early phases of capillarization in the CNS

We consider a general, neutral, dynamical model of biodiversity. Individuals have i.i.d. lifetime durations, which are not necessarily exponentially distributed, and each individual gives birth independently at constant rate \\lambda. We assume that types are clonally inherited. We consider two classes of speciation models in this setting. In the immigration model, new individuals of an entirely new species singly enter the population at constant rate \\mu (e.g., from the mainland into the island). In the mutation model, each individual independently experiences point mutations in its germ line, at constant rate \\theta. We are interested in the species abundance distribution, i.e., in the numbers, denoted I_n(k) in the immigration model and A_n(k) in the mutation model, of species represented by k individuals, k=1,2,...,n, when there are n individuals in the total population. In the immigration model, we prove that the numbers (I_t(k);k\\ge 1) of species ...

2010-01-01

250

Neutrino emission in neutron matter from magnetic moment interactions

Bundling of axons and capillarization of the neuroepithelium represent two of the numerous important events in brain development. Prerequisite for these two processes is a directed growth in the matrix-containing intercellular space before a final pattern is formed. The formation of the optical nerve in the region of the retina served as example to show that an extracellular substance with adhesive properties, the glycoprotein fibronectin, plays an important role during bundling and directed growth the axons. However, only small amounts of fibronectin are detected in the region of the capillary sprouts that penetrate into the neuroepithelium. In this area other substances, especially basement membrane components are present, e.g. for anchorage and stabilization. Hence, intercellular substances are also involved in the morphogenesis of the brain. Brain development comprises a great number of individual steps. Their knowledge is the prerequisite for an analysis of teratogenic and ...

251

Neutrino emission drives neutron star cooling for the first several hundreds of years after its birth. Given the low energy ($\\sim$ keV) nature of this process, one expects very few nonstandard particle physics contributions which could affect this rate. Requiring that any new physics contributions involve light degrees of freedom, one of the likely candidates which can affect the cooling process would be a nonzero magnetic moment for the neutrino. To illustrate, we compute the emission rate for neutrino pair bremsstrahlung in neutron-neutron scattering through photon-neutrino magnetic moment coupling. We also present analogous differential rates for neutrino scattering off nucleons and electrons that determine neutrino opacities in supernovae. Employing current upper bounds from collider experiments on the tau magnetic moment, we find that the neutrino emission rate can exceed the rate through neutral current electroweak interaction by a factor two, signalling ...

2004-01-01

252

Fermi pulsar revolution

Changes of the surface-to-volume ratio and diffusion coefficient of fission gas in fuel pellets during irradiation

2009 has been an extraordinary year for gamma-ray pulsar astronomy and 2010 promises to be equally good. Not only have we registered an extraordinary increase in the number of pulsars detected in gamma rays, but we have also witnessed the birth of new sub-families: first of all, the radio-quiet gamma pulsars and later an ever growing number of millisecond pulsars, a real surprise. We started with a sample of 7 gamma-ray emitting neutron stars (6 radio pulsars and Geminga) and now the Fermi-LAT harvest encompasses 24 "Geminga-like" new gamma-ray pulsars, a dozen millisecond pulsars and about thirty radio pulsars. Moreover, radio searches targeted to LAT unidentified sources yielded 18 new radio millisecond pulsars, several of which have been already detected also in gamma rays. Thus, currently the family of gamma-ray emitting neutron stars seems to be evenly divided between classical radio pulsars, millisecond pulsars and radio quiet neutron stars.

2010-01-01

253

Total skin electron beam therapy followed by adjuvant psoralen/ultraviolet-a light in the management of patients with T1 and T2 cutaneous T-cell lymphoma (mycosis fungoides)

Short-lived fission gas release from fuel pellets during irradiation was investigated based on the experimental results of the gas-flow rigs irradiated in the Halden Heavy Water Reactor (HBWR). The release-to-birth (R/B) rates of short-lived fission gas were measured by means of gas-flow measurement during the irradiation experiments. Surface-to-volume (S/V) ratios of fuel pellets and diffusion coefficients of short-lived fission gas release were evaluated from the obtained (R/B) values. The increase of (S/V) ratio agreed well with the point where the fuel temperature exceeded the threshold of 1% fission gas release. This indicates that the interlinkage of fission gas bubbles occurred there. The evaluated diffusion coefficients scattered in the range between 10"-"2"3 and 10"-"1"7 m"2/s, and the effects of fuel type (UO_2 or MOX) were not clearly observed. In addition, it is likely that the restructuring effect of fuel pellet on the diffusion coefficients of ...

2010-07-31

254

Depleted uranium munitions - where are we now?

Purpose: Patients with mycosis fungoides [cutaneous T-cell lymphoma (CTCL)] may benefit from adjuvant therapy after completing total skin electron beam therapy (TSEBT). We report the results for (T1(T2)) CTCL patients treated with adjuvant oral psoralen plus ultraviolet light (PUVA) with respect to overall survival (OS), disease-free survival (DFS), salvage of recurrence, and toxicity. Methods and Materials: Between 1974 and 1993, TSEBT was administered to a total of 213 patients with CTCL. Records were reviewed retrospectively, and a total of 114 patients were identified as having T1 or T2 disease. Radiotherapy was provided via a 6-MeV linac to a total of 36 Gy, 1 Gy/day, 4 days/week, for 9 weeks. Beginning in 1988, patients were offered adjuvant PUVA within 2 months of completing TSEBT. This was started at 0.5-2 J/m"2, 1-2 treatments/week, with a taper over 3-6 months. Therapy then continued once per month. There were 39 T1 and 75 T2 patients. Six T1 (15%) and eight T2 (11%) patients ...

1997-07-15

255

Synfuels from coal lessons: from South Africa

There are very different views on the health hazards of DU munitions. Most of the concerns of veterans and their advisors focus on the radiological effects of DU and consequently these are the focus of this editorial. Effects on the kidney and environmental consequences are, however, considered in the second of the Royal Society reports and the main conclusions of both of the reports are outlined in the summary document published in this issue of the journal. The main radiological concerns focus on the irradiation of lung tissues from inhaled DU particles and irradiation resulting from the translocation of inhaled particles to the thoracic lymph nodes.The overwhelming scientific view, presented in the two Royal Society reports and in other independent reviews, is that the main risks of exposure to DU aerosols are an increase in lung cancer and (from chemical toxicity) damage to the kidney, although these are likely to be evident only following substantial intakes. The equivalent doses ...

2002-06-01

256

Synfuels from coal lessons: from South Africa

The most significant lessons provided by these developments at SASOL are the importance of long-range planning and the need for establishing a commercialized technology base in synfuels. These are necessary to reduce our dependence on foreign energy sources and can be accomplished with suitable cooperation between government and private industry and between agencies within the government. The Fischer-Tropsch process is not the only method for producing gasoline from coal, but so far it is the only one commercially proven. Another process, which produces gasoline from methanol, has been considered for commercialization. The government of New Zealand decided in December 1979 to build a commercial-size plant using its abundant natural gas as the feedstock in a natural gas to methanol to gasoline process. Because methanol can also be produced from gasified coal, this process may be an attractive option for the production of gasoline from coal in the United States. ...

1980-07-01

257

Sodium monofluoroacetate (1080) risk assessment and risk communication

1980-07-01

258

Native kidney reincarnation following a failed transplant

Sodium monofluoroacetate (1080) is a vertebrate pesticide widely used for possum control in New Zealand. Fluoroacetate is also a toxic component of poisonous plants found in Australia, South Africa, South America, and India. Because of its importance and effectiveness in pest control and the highly toxic nature of this compound, its acute sub-lethal and target organ toxicity have been extensively studied. In relation to its use as a pesticide its environmental fate, persistence, non-target impacts and general toxicology have been and continue to be extensively studied. Toxic baits must be prepared and used with extreme care, otherwise humans, livestock, and non-target wildlife will be put at risk. The high risk of secondary poisoning of dogs is a cause for concern. 1080 acts by interfering with cellular energy production. Possums die from heart failure, usually within 6-18 h of eating baits. Long-term exposure to sub-lethal doses can have harmful effects and strict ...

2002-12-27

259

Mediation of bone ingrowth in porous hydroxyapatite bone graft substitutes.

Full text: A 51-year-old woman with end stage renal failure secondary to Haemolytic Uraemic syndrome underwent a cadaveric renal transplant. A routine post transplant DTPA scan was performed which demonstrated satisfactory renal transplant perfusion and function. Incidental note was made of tracer uptake in the pelvis in the mid-line, which was suspected to be a uterine fibroid. This was confirmed on ultrasonography and at surgery. One week post transplantation the patient became acutely unwell and at laparotomy a perforated diverticular abscess was drained. Intraoperatively the transplant kidney was examined and the surgeon thought there was a area of infarction. This was confirmed on biopsy. As the patient's creatinine was rising a repeat DTPA study was performed. Perfusion and function of the transplant kidney was virtually absent while Doppler studies showed no flow. The patient however continued to produce urine and the creatinine was stable. Subsequently a ...

2002-05-04

260

It`s slim with a plain green cover: Australia`s management plan for polychlorinated biphenyls

Previous investigations have shown that both the early biological response and the mechanical properties of a porous hydroxyapatite bone graft substitute are highly sensitive to its pore structure. The objective of this study was to evaluate whether the pore structure continued to influence bone integration in the medium to long term. Two screened batches of porous hydroxyapatite (PHA) designated as batch A and batch B, with porosities of approximately 60 and 80%, respectively, were selected for this study and implanted for periods of 5, 13, and 26 weeks into the lower femur of New Zealand White rabbits. Histomorphometric analysis of the absolute volume of bone ingrowth within batch A and B implants from 5 to 26 weeks showed that the absolute volume of bone ingrowth was consistently lower in batch A (10-21%), compared to batch B implants (24-31%). However, when the volume of bone ingrowth was normalised for the available pore space, this difference was reduced ...

2004-01-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16

261

Immunological correlates for protection against intranasal challenge of Bacillus anthracis spores conferred by a protective antigen-based vaccine in rabbits.

In November 1995, the Australian and New Zealand Environment and Conservation Council (ANZECC, the Council of State and National Environment Ministers) adopted a National Management Plan for PCBs. This was a significant milestone in the very long saga of Australian efforts to develop public policy and management structures for dealing with persistent organochlorine wastes. The author was part of a four-person consultation panel that carried out a public involvement program to assist and inform the process of developing the National Management Plan. The program involved, among other things, visiting every state and territory of Australia at least twice. This paper describes the development and delivery of the public involvement program, including ongoing interactions with Governments. The latter is often a complex (and many would say an unduly complex) matter in the federal system, where primary responsibility for waste management resides in the individual ...

1996-12-31

262

Fossil avian eggshell preserves ancient DNA

Correlates between immunological parameters and protection against Bacillus anthracis infection in animals vaccinated with protective antigen (PA)-based vaccines could provide surrogate markers to evaluate the putative protective efficiency of immunization in humans. In previous studies we demonstrated that neutralizing antibody levels serve as correlates for protection in guinea pigs (S. Reuveny et al., Infect. Immun. 69:2888-2893, 2001; H. Marcus et al., Infect. Immun. 72:3471-3477, 2004). In this study we evaluated similar correlates for protection by active and passive immunization of New Zealand White rabbits. Full immunization and partial immunization were achieved by single and multiple injections of standard and diluted doses of a PA-based vaccine. Passive immunization was carried out by injection of immune sera from rabbits vaccinated with PA-based vaccine prior to challenge with B. anthracis spores. Immunized rabbits were challenged by intranasal spore ...

2006-01-01

263

Brain SPECT of chronic fatigue syndrome (CFS): SPM analysis of two age groups

Owing to exceptional biomolecule preservation, fossil avian eggshell has been used extensively in geochronology and palaeodietary studies. Here, we show, to our knowledge, for the first time that fossil eggshell is a previously unrecognized source of ancient DNA (aDNA). We describe the successful isolation and amplification of DNA from fossil eggshell up to 19 ka old. aDNA was successfully characterized from eggshell obtained from New Zealand (extinct moa and ducks), Madagascar (extinct elephant birds) and Australia (emu and owl). Our data demonstrate excellent preservation of the nucleic acids, evidenced by retrieval of both mitochondrial and nuclear DNA from many of the samples. Using confocal microscopy and quantitative PCR, this study critically evaluates approaches to maximize DNA recovery from powdered eggshell. Our quantitative PCR experiments also demonstrate that moa eggshell has approximately 125 times lower bacterial load than bone, making it a highly ...

2010-01-01

264

166Ho-HA evaluation as therapeutic agent for rheumatoid arthritis treatment

Full text: Chronic fatigue syndrome (CFS) is a complex disorder characterised by profound fatigue and neuropsychiatric dysfunction. Previous studies with cerebral perfusion SPECT (rCBF) scans were performed with inhomogeneous patient populations and were not analysed with Statistical Parametric Mapping (SPM). We have used SPM to study subjects with moderate CFS based on the Fukuda criteria, who were not on medication and not depressed, compared to age matched control subjects. An apparent bimodal age distribution has been observed in CFS. Subjects were therefore divided into two age groups: 16-35 or under 35 (17 CFS, 11 control) and 36-61 or over 35 (15 CFS, 15 control). HMPAO brain SPECT was acquired on a 3-head camera. After lower window scatter subtraction, reconstruction with attenuation correction (mu=0.15/cm) and editing of facial activity, scans were spatially normalised (affine + 2x3x2 nonlinear) to SPM's anatomical space. SPM statistical analysis yielded the location, ...

2002-05-04

265

[The nurturing and development of nurse practitioners].

Aim: Rheumatoid arthritis is a limiting disease having, among its pathological features, the inflammation of synovial tissue with progressive and later destruction of the articulation. This leads to joint deformation and loss of its function, generating pain and reducing the mobility of the affected articulation. The aim was to evaluate "1"6"6Ho-Hydroxyapatite ("1"6"6 Ho-HA) as potential radiopharmaceutical for the symptomatic treatment of chronic and acute arthritis. Materials and Methods: Holmiun-166 was produced by irradiation of Ho_2O_3 at La Reina Research Reactor, Nuclear Chilean Energy Commission. Hydroxyapatite was in-house synthesized. Its labelling and quality controls follows the internationally accepted procedures. An antigen's arthritis was induced to eight New Zealand rabbits with the "1"6"6 Ho-HA radiochemical being administered thereafter in two dosage modalities (single and double). The compound therapeutic efficiency was evaluated based upon ...

2002-09-01

266

Primary adenocarcinoma of the urinary bladder: value of cell cycle biomarkers.

The role of nurse practitioner has been established because of a shortage of doctors. In May 2007, the first cohort of 582 nurse practitioners were licensed in Taiwan. The post of nurse practitioner in Taiwan is formally moving towards systematization and the most urgent matters in that regard are the sorting out of contentious issues and the establishment of clear job descriptions. Competence in critical thinking and problem-based learning is important and has to be improved with practice. The application of teaching assessment tools such as direct observation procedural skills (DOPS), objective structured clinical examination (OSCE), miniclinical evaluation exercises (Mini-CEX), and 360 degree assessments may contribute to the improvement of nurse practitioners' skills in conducting research, appraising evidence-based nursing literature, and developing teaching strategies and advanced systems by making policy clear, evaluating, auditing and monitoring the ...

2007-12-01

267

Musculoskeletal injuries in an Army airborne population.

Primary adenocarcinomas of the urinary bladder are uncommon, and the molecular pathways are currently not well defined. In this study, we assessed the association between biologic markers and clinicopathologic characteristics in a cohort of 21 patients with primary urinary bladder adenocarcinoma. Immunohistochemical staining for cell cycle-specific markers, including p53, p21, p27, Ki-67, and cyclin E, were performed on sections of a tissue microarray construct. The tumors were high grade in 12 (57%) and pT2 or higher in 18 (86%); lymph nodes were involved in 6 cases (29%); and there was pathologic evidence of schistosomiasis in 14 (67%). The best prognostic combination of markers was combined alterations in p27 and Ki-67 and was associated with stage (P = .012), grade (P = .005), DNA ploidy (P = .005), and lymph node involvement (P = .04). Stage, lymph node involvement, combined alterations of p27 and Ki-67, and combined alterations of all 5 biomarkers were ...

2011-06-01

268

Magnetic resonance imaging: early detection of central nervous system involvement in acquired immunodeficiency syndrome (AIDS)

To maintain operational readiness, military personnel engage in vigorous physical and training activities that carry risk for injury. A 1-year prospective cohort study, starting April 1996, was conducted at Fort Bragg, North Carolina among 1,965 members of the 82nd Airborne Division to quantify musculoskeletal injuries. Information collected included type of injury, site, circumstances, and resultant limited duty days. These soldiers suffered 508 overuse injuries (including 38 stress fractures), 1,415 traumatic injuries (including 100 fractures), and 101 unclassified injuries. Injury rates were 6.8% per soldier per month for traumatic injury and 2.4% for overuse injury (totaling 1.2 injuries per soldier per year). Injuries resulted in 22,041 limited duty days, averaging 11 days per injury and 13 days per soldier (4.5% of total workdays). Fractures and stress fractures/reactions produced the most days lost per case. Most of these injuries resulted from ...

2002-12-01

269

Life history consequences of growth variation

Central Nervous System (CNS) involvement, whether primary by the Human Immunodeficiency Virus - HIV - itself, or secondary (toxoplasmosis or lymphoma) is remarkably frequent in AIDS, in 40 to 70% of cases, depending upon the author. In order to study the natural history of this illness, a cohort of 25 asymptomatic seropositive patients have been established. Every 6 months these patients undergo biological and clinical examinations, as well as Magnetic Resonance brain scans. After two examinations at a 6 month's interval, the first results are reported. Out of these 25 cases, 9 present anomalies: One patient with diffuse cerebral atrophy and 8 others with high signal intensity areas on T2 weighted sequences, like those of the Multiple Sclerosis. No relationship could be demonstrated between the existence of these lesions and various criteria such as age, sex, risk factors and T4 cells count. The nature of these lesions is not lear. They certainly indicate early ...

270

Environmental Research Database

ObjectivesThe main objective of this study is to address the following specific questions: 1. Are the delayed effects of poor early diet on whole organism performance and senescence contingent on, or exacerbated by, the subsequent occurrence of compensatory growth? 2. Does the rate of growth influence levels of resting metabolism and/or oxidative stress, and if so, for how long does this persist? 3. How are the levels of early nutrition, growth, resting metabolism and oxidative stress linked to the lev [continued...]DescriptionIt is now widely appreciated that, while animals may appear to recover from periods of poor food quality or quantity experienced in early development, adverse effects may occur later in adult life. Such effects can influence the performance of complete cohorts of animals, and have important consequences for population dynamics. The reasons why such delayed effects occur across the animals' lifetimes are poorly understood. Following a period ...

2009-01-30

271

Home radon levels and seasonal correction factors for the Isle of Man

Glycemic Control and Pregnancy Outcomes in Women with Type 1 Diabetes Mellitus Using Lispro Versus Regular Insulin: A Systematic Review and Meta-Analysis

Ionizing radiation dose levels due to home radon can rise to levels that would be illegal for workers in the nuclear industry. It is well known that radon levels within homes and from home to home, and also from month to month, vary considerably. To define an Isle of Man radon seasonal correction factor, readings were taken in eight homes over a 12 month period. An average island indoor exposure of 48 Bq m{sup -3} (range 4-518 Bq m{sup -3}) was determined from 285 homes selected from a cohort of 1300 families participating in the European Longitudinal Study of Pregnancy and Childhood (ELSPAC) in the Isle of Man. This compares with a UK home average of 20 Bq m{sup -3} and a European Union average (excluding UK) of 68 Bq m{sup -3}. Ten homes of those measured were found to have radon levels above the National Radiological Protection Board 200 Bq m{sup -3} action level. There are 29 377 homes on the Isle of Man, suggesting that there could be some 900 or more homes ...

2000-08-01

272

British Library Electronic Table of Contents (United Kingdom)

Abstract Aims: This study performed a systematic review and meta-analysis on glycemic control and pregnancy outcomes in women with type 1 diabetes mellitus (T1DM) treated with lispro (LP) versus regular insulin (RI) since before pregnancy. Methods: We performed a MEDLINE and EMBASE search. Abstracts (and full articles when appropriate) were reviewed by two independent researchers. Inclusion criteria were patients with T1DM, data on women treated with RI and LP since before pregnancy until delivery in the same article, at least five pregnancies in each group, and information on at least one pregnancy outcome. Quality assessment was performed using the Newcastle?Ottawa Quality Assessment Scale for cohort studies. Results: Outcome data were summarized with Revman version 5.0 (ims.cochrane.org...

2011-01-01

273

Epidemiologic studies of coronary heart disease and stroke in Japanese men living in Japan, Hawaii, and California: demographic, physical, dietary, and biochemical characteristics

Effect of clindamycin treatment on vaginal inflammatory markers in pregnant women with bacterial vaginosis and a positive fetal fibronectin test

These summary descriptive data of ethnically similar cohorts of indigenous and migrant Japanese males have shown similarities or slight differences in characteristics wholly or largely genetically determined, such as blood groups, stature, and skeletal size. Differences have been noted in characteristics largely environmental or behavioral, such as diet and cigarette smoking habit, as well as in characteristics determined by a varying mixture of genetic and environmental influences, such as weight, blood pressure, glucose tolerance, and serum lipid and uric acid levels. Detailed analyses of the distributions of laboratory variables, of dietary data obtained by different methods, and of correlations among laboratory, dietary, physical, and demographic variables are currently in progress. Also part of the study plan are determinations of disease prevalence from evaluation of examination, laboratory, and electrocardiographic findings, of disease incidence from repeat ...

274

British Library Electronic Table of Contents (United Kingdom)

Objective To compare the levels of interleukin (IL)-1?, IL-6, and matrix metalloproteinase (MMP)-8 in the vaginal secretions of pregnant women with a positive fetal fibronectin (fFN) test result with or without asymptomatic bacterial vaginosis (BV) before and after treatment with oral clindamycin. Methods A prospective cohort study was conducted among 43 pregnant women with a positive fFN test result. All patients were treated with clindamycin, and the pre- and post-treatment levels of IL-1?, IL-6, and MMP-8 were compared. Results Before treatment, levels of IL-1? and MMP-8 were significantly higher in women with BV compared with women without BV (P<0.05). Vaginal levels of IL-1? and IL-6, but not MMP-8, decreased after treatment in pregnant women with BV. Conclusions The inability of clin...

2009-01-01

275

Automated segmentation and quantitative characterization of radiodense tissue in digitized mammograms

An estimation of the long-term clinical and economic benefits of insulin lispro in Type 1 diabetes in the UK

Mammography has emerged as a reliable non-invasive technique for the early detection of breast cancer--the second leading cause of cancer-related mortality among American women. The radiographic appearance of the female breast consists of radiolucent (dark) regions due to fat and radiodense (light) regions due to connective and epithelial tissue. The amount of radiodense tissue can be used as a marker for predicting breast cancer risk. This paper presents the development of an algorithm for estimating the percentage of radiodense tissue in a digitized mammogram. The technique involves determining a dynamic threshold for segmenting radiodense indications in mammograms. Both the mammographic image and the threshold are modeled as Gaussian random variables. This work is intended to support a concurrent study at the Fox Chase Cancer Center (FCCC) exploring the association between dietary patterns and breast cancer risk. Mammograms have been obtained from an existing ...

2002-05-25

276

British Library Electronic Table of Contents (United Kingdom)

Abstract Aims To determine the long-term health economic benefits associated with lispro vs. regular human insulin (RHI) in UK Type 1 diabetic (T1DM) patients using the previously published and validated CORE Diabetes Model. Methods A literature review designed to capture clinical benefits associated with lispro and T1DM cohort characteristics specific to UK was undertaken. Clinical benefits were derived from a Cochrane meta-analysis. The estimated difference (weighted mean) in glycated haemoglobin (HbA1c) was -0.1% (95% confidence interval -0.2 to 0.0%) for lispro vs. RHI. Severe hypoglycaemia rates for lispro and RHI were 21.8 and 46.1 events per 100 patient years, respectively. Costs and disutilities were accounted for severe hypoglycaemia rates. All costs were accounted in 2007 UK from...

2009-01-01

277

Radiation epidemiological analysis of late effects of population exposure at northern part of east ural radioactive trace

Measurement of energy expenditure in overweight men and women using [C-14]-bicarbonate-urea before and after weight loss

Population residing in the northern part of the Chelyabinsk oblast and the south eastern part of the Sverdlovsk oblast of Russia affected to accidental exposure since 1957. The territory (East Ural Radioactive Trace - EURT) was contaminated after explosion of container with highly radioactive wastes at the Mayak Production Association. Studies of health effects of exposure in the southern, head part of EURT are conducted in the Ural Research and Practical Center of Radiation Medicine (U.R.P.R.M.). In the 1990's U.R.P.C.R.M. formed a cohort of EURT within Chelyabinsk oblast (14,500 cases and 19,400 external controls). The cohort was followed in 1957-1987 and the results of the study are discussed by Crestinina et al. First results of study on exposure late health effects among rural population in the northern part of the EURT are presented in this paper. Firstly, or the period 1958-2000 a statistically significant increase in cancer ...

2006-07-01

278

Radiation therapy for Kasabach-Merritt syndrome. Analysis of unfavorable factors in 5 children

Full text: Many studies have demonstrated significant declines in 24-hour energy expenditure (TEE) measured by whole body calorimetry with either the process of weight loss or the maintenance of reduced body weight. The aims of this study were to determine the effect of weight loss and two weeks of weight maintenance on TEE using ["1"4C]-bicarbonate-urea, Eleven subjects (6 males, 5 females), mean (#+-#SE) age 50 #+-# 3 years, BMI 34.1 #+-# 2.1 kg/m2 and body fat 38.7 #+-# 3% were studied before and after a decrease in body weight of > 8% over a period of 8 weeks, followed by two weeks of weight maintenance. Weight loss was induced using the combination of Modifast and one small meal a day (#approx#3.34 MJ/day). Body composition (DEXA), resting energy expenditure (REE) and the thermic effect of a 2.7 MJ test meal (TEF) were measured in addition to TEE at week 2 and again at week 12. Diet was assessed using diaries and physical activity energy expenditure (PAEE) was calculated from ...

2002-05-04

279

Postnatal food restriction in the rat as a model for a low nephron endowment.

During the past 10 years, five infants with Kasabach-Merritt syndrome (K-M) receiving radiation therapy were reported. We investigated whether radiation therapy for K-M was useful and what the unfavorable factors of K-M were. During the past 10 years, we have treated five infants with K-M. The syndrome occurred at ages ranging from birth to 4 months. The incidence of female to male ratio was 3:2. Among 5 cases, the site of hemangioma was as follows; shoulder, anterior chest wall, lower abdominal wall, face and neck and inguinal site. All 5 cases received medication to control the coagulopathy including prednisone and blood transfusion at first. Because the platelet count and the bleeding tendency did not improve in any case, these cases received radiation therapy. Total dose ranged from 5 to 10 Gy and fraction-size ranged from 0.5 to 1.75 Gy. Irradiation session was 2 or 3 times per week. In 5 cases, 4 cases showed cure of bleeding tendency and disappearance of ...

1996-03-01

280

ON THE POSSIBILITY OF ENRICHMENT AND DIFFERENTIATION IN GAS GIANTS DURING BIRTH BY DISK INSTABILITY

A low nephron endowment may be associated with hypertension. Nephrogenesis is the process that leads to the formation of nephrons until week 36 of gestation in humans and may be inhibited by many factors like intrauterine growth restriction and premature birth. To study the consequences of a low glomerular number, animal models have been developed. We describe a model of postnatal food restriction in the rat in which litter size is increased to 20 pups, which leads to growth restriction. In the rat, active nephrogenesis continues until postnatal day 8, which coincides with the growth restriction in our model. Design-based stereological methods were used to estimate glomerular number and volume. Our results show an approximately 25% lower glomerular number in rats after postnatal food restriction (30,800 glomeruli/kidney) compared with control rats (39,600 glomeruli/kidney, P < 0.001). Mean glomerular volume was increased by 35% in the growth-restricted rats (P = ...

2006-01-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16

281

Magnetic resonance imaging assessment of brain maturation in preterm neonates with punctate white matter lesions

We investigate the coupling between rock-size solids and gas during the formation of gas giant planets by disk fragmentation in the outer regions of massive disks. In this study, we use three-dimensional radiative hydrodynamic simulations and model solids as a spatial distribution of particles. We assume that half of the total solid fraction is in small grains and half in large solids. The former are perfectly entrained with the gas and set the opacity in the disk, while the latter are allowed to respond to gas drag forces, with the back reaction on the gas taken into account. To explore the maximum effects of gas-solid interactions, we first consider 10 cm size particles. We then compare these results to a simulation with 1 km size particles, which explores the low-drag regime. We show that (1) disk instability planets have the potential to form large cores due to aerodynamic capturing of rock-size solids in spiral arms before fragmentation; (2) temporary clumps can concentrate tens ...

2010-11-20

282

Functional magnetic resonance imaging of the normal and abnormal visual system in early life.

Early white matter (WM) injury affects brain maturation in preterm infants as revealed by diffusion tensor imaging and volumetric magnetic resonance (MR) imaging at term postmenstrual age (PMA). The aim of the study was to assess quantitatively brain maturation in preterm infants with and without milder forms of WM damage (punctate WM lesions, PWML) using conventional MRI. Brain development was quantitatively assessed using a previously validated scoring system (total maturation score, TMS) which utilizes four parameters (progressive myelination and cortical infolding, progressive involution of glial cell migration bands and germinal matrix tissue). PWML were defined as foci of increased signal on T1-weighted images and decreased signal on T2-weighted images with no evidence of cystic degeneration. A group of 22 preterm infants with PWML at term PMA (PWML group) were compared with 22 matched controls with a normal MR appearance. The two groups were comparable concerning gestational ...

2007-02-01

283

Characterization of monocyte differentiation-inducing (MDI) factors derived from human fetal membrane chorion cells undergoing apoptosis after influenza virus infection.

Functional magnetic resonance imaging (fMRI) in young children may provide information about the development of the visual cortex, and may have predictive value for later visual performance. The purpose of this study was to evaluate the usefulness of fMRI for examining cerebral processing of vision in very young infants and in infants with brain damage. We examined 15 preterm infants, 12 children suspected of having a cerebral visual impairment and 10 children with a normal visual system, all of whom were either spontaneously asleep or sedated with chloral hydrate. Cortical response to stroboscopic light stimulation could be demonstrated in all technically acceptable data sets from children with a post-menstrual age (PMA) of > 41 weeks, but not in younger infants. Children < 60 weeks PMA showed either a blood oxygenation level-dependent (BOLD) signal increase or decrease, while all older children showed a signal decrease. The activated cortical volumes showed a linear relation to ...

2000-01-01

284

Case report: Denys- Drash syndrome.

Influenza virus infection during pregnancy has been implicated as one of cause of premature delivery, abortion and stillbirth. We have reported that cultured human fetal membrane chorion cells undergoing apoptosis by influenza virus infection secrete unidentified heat-stable monocyte differentiation-inducing (MDI) factors. In this study, cellular, biological and immunochemical characteristics of MDI factors were investigated using human monocytic leukemia THP-1 cells by nitroblue tetrazolium reduction and cell adhesion assays. The treatment of THP-1 cells with culture supernatants from the influenza virus-infected chorion cells induced the nitroblue tetrazolium reduction ability, which was inhibited by the addition of superoxide dismutase and diphenyleneiodonium chloride, an inhibitor for reduced nicotinamide adenine dinucleotide phosphate oxidase. The phenomenon was also observed in human peripheral blood monocytes and histiocytic leukemia U937 cells, but not in promyelocytic leukemia ...

2006-06-06

285

Alpha particle destabilization of the toroidicity-induced Alfven eigenmodes

BACKGROUND: Denys-Drash Syndrome (DDS) is an uncommon disorder that appears sporadically and in rare cases may be inherited as an autosomal dominant trait It manifests either at birth or within the first year of life and typically consists of the triad of congenital nephropathy, Wilms tumour and intersex disorder. CASE REPORT: A 10 year-old Caucasian girl was referred to the Dental Department, at Glasgow Royal Hospital for Sick Children by her Paediatric Nephrologist Consultant. The patient was being teased by her peers over her markedly discoloured teeth. The dental history revealed that the patient was a regular dental attendee from an early age. She was dentally anxious having only experienced dental treatment under general anaesthesia (GA) when she was 4 years old. Apparently her primary dentition also showed a generalised discolouration. TREATMENT: This consisted of multiple visits for diet analysis and tooth brushing instruction with the use of disclosing ...

2007-12-01

286

A phenomenological finite element model of stereolithography processing

The high frequency, low mode number toroidicity-induced Alfven eigenmodes (TAE) are shown to be driven unstable by the circulating and/or trapped {alpha}-particles through the wave-particle resonances. Satisfying the resonance condition requires that the {alpha}-particle birth speed v{sub {alpha}} {ge} v{sub A}/2{vert bar}m-nq{vert bar}, where v{sub A} is the Alfven speed, m is the poloidal model number, and n is the toroidal mode number. To destabilize the TAE modes, the inverse Landau damping associated with the {alpha}-particle pressure gradient free energy must overcome the velocity space Landau damping due to both the {alpha}-particles and the core electrons and ions. The growth rate was studied analytically with a perturbative formula derived from the quadratic dispersion relation, and numerically with the aid of the NOVA-K code. Stability criteria in terms of the {alpha}-particle beta {beta}{sub {alpha}}, {alpha}-particle pressure gradient parameter ...

1990-10-01

287

Vascular complications following 1500 consecutive living and cadaveric donor renal transplantations: A single center study

In the stereolithography process, three dimensional parts are built layer by layer using a laser to selectively cure slices of a photocurable resin, one on top of another. As the laser spot passes over the surface of the resin, the ensuing chemical reaction causes the resin to shrink and stiffen during solidification. When laser paths cross or when new layers are cured on top of existing layers, residual stresses are generated as the cure shrinkage of the freshly gelled resin is constrained by the adjoining previously-cured material. These internal stresses can cause curling in the compliant material. A capability for performing finite element analyses of the stereolithography process has been developed. Although no attempt has been made to incorporate all the physics of the process, a numerical platform suitable for such development has been established. A methodology and code architecture have been structured to allow finite elements to be birthed (activated) ...

1996-03-01

288

Risk of malignant lymphoma in patients with inflammatory bowel diseases: A Dutch nationwide study.

The aim of this study was to document vascular complications that occurred following cadaveric and living donor kidney transplants in order to assess the overall incidence of these complications at our center as well as to identify possible risk factors. In a retrospective cohort study, 1500 consecutive renal transplant recipients who received a living or cadaveric donor kidney between December 1988 and July 2006 were evaluated. The study was performed at the Nemazee Hospital, Shiraz, Iran. The assessment of the anatomy and number of renal arteries as well as the incidence of vascular complications was made by color doppler ultrasonography, angiography, and/or surgical exploration. Clinically apparent vascular complications were seen in 8.86% of all study patients (n = 133) with the most frequent being hemorrhage (n = 91; 6.1%) followed by allograft renal artery stenosis (n = 26; 1.7%), renal artery thrombosis (n = 9; 0.6%), and renal vein thrombosis (n = 7; 0.5%). ...

289

Radiotherapy for brain metastases from renal cell cancer. Should whole-brain radiotherapy be added to stereotactic radiosurgery? Analysis of 88 patients

BACKGROUND: Immune suppressant medications such as thiopurines and anti-tumor necrosis factor agents are important for maintaining disease control in most patients with inflammatory bowel diseases (IBDs); however, their use has been associated with the development of malignant lymphoma. The purpose of this Dutch nationwide study was to estimate the relative risk of malignant lymphoma in IBD patients. METHODS: IBD patients who developed a lymphoma between 1997 and 2004 were identified using the Dutch National Database of PALGA. Data from confirmed cases were collected from individual hospitals, including data on Epstein-Barr virus (EBV). The age-adjusted 8-year incidence of malignant lymphoma in the Netherlands was retrieved from the Central Bureau of Statistics. RESULTS: Forty-two hospitals were visited and 285 matches evaluated in the total cohort of 17,834 IBD patients. Forty-four lymphomas were observed, resulting in a relative risk of 1.27 (95% confidence ...

2010-12-22

290

Radiation therapy for Ewing's sarcoma: Results from Memorial Sloan-Kettering in the modern era

Purpose: To evaluate the role of stereotactic radiosurgery (SRS) and whole-brain radiotherapy (WBRT) for the treatment of brain metastases in patients with renal cell cancer (RCC). Patients and methods: 88 patients were treated with either SRS (n = 51) or SRS + WBRT (n = 17) for one to three lesions, or with WBRT (n = 20) for more than three brain metastases. Overall survival (OS), intracerebral control (IC) and local control (LC) were retrospectively analyzed. Six potential prognostic factors were assessed: age, gender, number of brain metastases, extracerebral metastases, recursive partitioning analysis (RPA) class, and interval from tumor diagnosis to irradiation. Results: The median times for OS, IC, and LC from the time of diagnosis were 11, 9, and 10 months. The median OS times for SRS, SRS + WBRT, and WBRT were 12, 16, and 2 months. Addition of WBRT to the SRS improved IC (p = 0.032) but not OS (p = 0.703). On multivariate analyses, improved OS was associated with the absence of ...

2010-04-01

291

Prospects and future of conservative management of beta thalassemia major in a developing country

Purpose: To evaluate the outcomes of patients with Ewing's sarcoma family of tumors (ESFT) treated with modern radiotherapy techniques with MRI along with optimal chemotherapy. Methods and Materials: The records of all 60 patients with ESFT who received radiation to the primary site between 1990 and 2004 were reviewed. All patients received chemotherapy, including vincristine, doxorubicin, cyclophosphamide, ifosfamide, and etoposide. Radiation was used as the sole modality for local control in 31 patients and was given either before (n = 3) or after surgical resection (n = 26) in the remainder. All patients had MRI and CT scan-based treatment planning, and 43% received intensity-modulated radiation therapy. Radiation doses ranged from 30 Gy to 60 Gy (median, 51 Gy), and 35% received hyperfractionated radiotherapy. Results: Median age was 16 years (range, 2-40 years). Because of selection bias for radiotherapy, the majority of primary tumors were centrally located (72%): spine (n = 18), ...

2006-02-01

292

Prevalence and Associations of Anxiety Disorders in Adults with Intellectual Disabilities

Objective: To assess the efficacy, prospects and future of conservative management of beta thalassemia major patients in a developing country. Design: Patients registered at IHBTS were studied over a period of three years. They consented to being managed on moderate transfusion regimen, aiming to maintain a pre-transfusion haemoglobin(Hgb) level of 9.0 plus minus 1.0 g per dL. We studied their transfusion requirements, status for transfusion transmitted infections (TTls), serum ferritin levels and complications developing as a result of iron overload. Subjects: Initially all registered patients were included in this study. Sporadic patients as well as dropouts occurring due to any reason, (patients concurrently seeking treatment at other centres as well, or complying poorly to advised chelation therapy) were excluded from the study. The data presented here conforms to a cohort of 60 regular patients who adhered best to our selection criteria. Main Outcome Measures: ...

2004-01-01

293

Preoperative assessment of hilar cholangiocarcinoma using multidetector-row CT. Correlation with histopathological findings

Background: Anxiety disorders are known to be common in the general population. Previous studies with adults with intellectual disabilities (IDs) report a prevalence of general anxiety disorder ranging from less than 2% to 17.4%. Little is known about associated factors in this population. This study investigates point prevalence of anxiety disorders and determines the factors independently associated with them. Methods: Information was collected with 1023 adults with IDs who participated in a large-scale, population-based study. All had a comprehensive physical and mental health assessment. The point prevalence of anxiety disorders according to different diagnostic criteria was determined, as were independently associated factors by using logistic regression analysis. Results: Three point eight per cent (95% CI = 2.7-5.2%) of the cohort had an anxiety disorder at the time of assessment. Generalised anxiety disorder was the most common (1.7%), then agoraphobia ...

2011-02-01

294

Origin of XMRV and its Demise as a Human Pathogen Associated with Chronic Fatigue Syndrome.

Our aim was to investigate the diagnostic reliability of multidetector-row computed tomography (MDCT) for preoperative assessment of local tumoral spread in hilar cholangiocarcinoma. Thirteen of 30 consecutive patients with hilar cholangiocarcinoma who underwent surgery, excluding 17 patients who underwent biliary drainage or preoperative portal embolization, were retrospectively evaluated. Using MDCT systems of 4 detector rows or 16 detector rows, plain and dynamic contrast-enhanced images of three phases were obtained. Extent of tumor spread and lymph node metastasis were assessed with MDCT and compared with histopathological findings. The Bismuth-Corlette classification of hilar cholangiocarcinoma with MDCT were type I, 1 patient; type IIIa, 3 patients; type IIIb, 4 patients; and type IV, 5 patients; those with histopathological findings were type I, 1 patient; type IIIa, 2 patients; type IIIb, 4 patients; and type IV, 6 patients. One patient diagnosed as type IIIa with MDCT was ...

2008-08-01

295

Menstrual variation of breast volume and T{sub 2} relaxation times in cyclical mastalgia

Retroviruses are well known pathogens of mammals, birds and fish. Their potential to induce cancer in chickens was already described almost 100 years ago and murine retroviruses have been a subject of study for 50 years. The first human retroviruses, HTLV and HIV, were discovered more than 30 years ago, surprising researchers and physicians by the profound differences in the diseases they cause. HTLV-1 is able to induce, after decades of infection, lymphomas/leukemia or neuroimmune disorders whereas untreated HIV infection leads almost inevitably to AIDS. The recently described XMRV (xenotropic murine leukemia virus-related virus) appeared to possess many of the features known for HTLV and was regarded by some to be the third human retrovirus. However, recent publications by Knox et al. [1] and Paprotka et al. [2] have shed new light on this gammaretrovirus. Knox and colleagues clearly demonstrate that XMRV is absent in patients belonging to a chronic fatigue syndrome ...

2011-07-27

296

Investigations of excretion rates of the radionuclides {sup 230}Th, {sup 226}Ra, {sup 210}Pb and {sup 210}Po of persons of the general population and of workers in selected regions in Germany

Purpose: Hormonal activity causes breast volume to change during the menstrual cycle. One possible cause of this volume change is thought to be due to water retention or oedema within the tissues. We used magnetic resonance imaging (MRI) to study the variation in breast volume and {sup 1}H Magnetic Resonance Spectroscopy (MRS) to measure T{sub 2} relaxation times which are known to increase with increasing tissue water content. We hypothesised that an increase in breast volume will elevate T{sub 2} relaxation due to the presence of an increased water content within the breast. T{sub 2} Relaxation time and volume were studied in fifteen control subjects and in a cohort of eight patients with cyclical mastalgia in order to determine whether changes in breast volume and T{sub 2} relaxation times differed in controls and patients during menses, ovulation and premenses. Method: Breast volume was determined by the Cavalieri method in combination with point counting ...

2008-02-15

297

Investigation on the state of health (1993-1997) in ambient residents of Daya Bay Nuclear Power Plant in the early days

According to ICRP 60 and European-Directive 96/29, Naturally Occurring Radioactive Materials (NORM) and Technical Enriched Naturally Occurring Radioactive Materials (TENORM) have to take the radiation protection of the general population as well as of workers into account. The German radiation protection regulations stress that particularly. In connection with these regulations, various measurement programs have been and still are performed to investigate the relevant exposure paths. One of these programs is the determination of the intake of natural occurring radionuclides of the uranium decay series in individuals of the public, in exposed regions and houses and also at NORM workplaces by excretion analysis. Excretion analysis surveillance is one of the common tools for internal dosimetry. Sources of primordial radionuclides could be the ingestion of foodstuff and water and the incorporation of (mostly airborne) pollution on work places. The main focus in this report is set upon the ...

2006-07-01

298

Comparison of 6 MV and 18 MV photons for IMRT treatment of lung cancer

Objective: To survey the data for the state of health in the ambient residents of Daya Bay Nuclear Power Plant, and provide the background data to evaluate the state of health affected by fallout of nuclear power plant. Methods: The datas were collected by a radiation epidemiology. The investigation was carried out in the area within 20 km of radius from Daya Bay Nuclear' Power Plant, and the subjects who had lived there for three years or longer before January. 1,1993 and covered by the Household Registry were recruited to a cohort. Results: The mortality rate of overall cancer (per 100 000 PYr) was 88.57 (the standard mortality rate was 79.77 ), the mortality rate of leukemia (per 100 000 PYr) was 3.24 (the standard mortality rate was 2.94), the palpation rate of the goiter in 7-14 years old was 8.34%(9.69% in B ultrasonic), the morbidity rate of newborn's defect (per 100 00 P) was 82.33. The mortality of all cancers or leukemia was similar to the result from ...

2005-06-01

299

Aarskog-Scott syndrome: Clinical update and report of nine novel mutations of the FGD1 gene

Background and purpose: To compare 6 MV and 18 MV photon intensity modulated radiotherapy (IMRT) for non-small cell lung cancer. Materials and methods: Doses for a cohort of 10 patients, typical for our department, were computed with a commercially available convolution/superposition (CS) algorithm. Final dose computation was also performed with a dedicated IMRT Monte Carlo dose engine (MCDE). Results: CS plans showed higher D _9_5_% (Gy) for the GTV (68.13 vs 67.36, p = 0.004) and CTV (67.23 vs 66.87, p = 0.028) with 18 than with 6 MV photons. MCDE computations demonstrated higher doses with 6 MV than 18 MV in D _9_5_% for the PTV (64.62 vs 63.64, p = 0.009), PTV_o_p_t_i_m (65.48 vs 64.83, p = 0.014) and CTV (66.22 vs 65.64, p = 0.027). Dose inhomogeneity was lower with 18 than with 6 MV photons for GTV (0.08 vs 0.09, p = 0.007) and CTV (0.10 vs 0.11, p = 0.045) in CS but not MCDE plans. 6 MV photons significantly (D _3_3_%; p = 0.045) spared the esophagus in MCDE ...

2007-01-01

300

A study of the lifetime occurrence of neoplasia and breed differences in a cohort of German Shepherd Dogs and Belgian Malinois military workingn> dogs that died in 1992.

Mutations in the FGD1 gene have been shown to cause Aarskog-Scott syndrome (AAS), or facio-digito-genital dysplasia (OMIM#305400), an X-linked disorder characterized by distinctive genital and skeletal developmental abnormalities with a broad spectrum of clinical phenotypes. To date, 20 distinct mutations have been reported, but little phenotypic data are available on patients with molecularly confirmed AAS. In the present study, we report on our experience of screening for mutations in the FGD1 gene in a cohort of 60 European patients with a clinically suspected diagnosis of AAS. We identified nine novel mutations in 11 patients (detection rate of 18.33%), including three missense mutations (p.R402Q; p.S558W; p.K748E), four truncating mutations (p.Y530X; p.R656X; c.806delC; c.1620delC), one in-frame deletion (c.2020_2022delGAG) and the first reported splice site mutation (c.1935+3A>C). A recurrent mutation (p.R656X) was detected in three independent families. ...

2010-01-01

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301

A cohort study of the effects of Vietnam service on testicular pathology of U.S. military workingn> dogs.

The population of U.S. Department of Defense military working dogs provides an opportunity to study the lifetime occurrence of neoplasia in 2 breeds of dogs--the German Shepherd Dog and the Belgian Malinois. Medical records were reviewed for all dogs that died or were euthanized in 1992 (135 German Shepherd Dogs and 106 Belgian Malinois). Histologically confirmed neoplasms were recorded. More than 30% of both breeds (41 German Shepherd Dogs and 33 Belgian Malinois) developed at least 1 primary neoplasm during their lives, with 10% developing more than 1 neoplasm. Nearly 57% of the neoplasms were benign, and approximately 43% were malignant. German Shepherd Dogs lived 9.7 years, on average, and Belgian Malinois lived 7.9 years, on average. Of the dogs that developed any neoplasm, Belgian Malinois had a mean age at 1st diagnosis that was 1.1 years younger and a mean age at 1st diagnosis of malignancy that was 1.7 years younger than those in German Shepherd Dogs. The risk of a malignancy ...

302

Heated lipiodol as an embolization agent for transhepatic arterial embolization in VX2 rabbit liver cancer model

Using histopathologic diagnoses made on necropsy material from 3,024 military working dogs (MWDs) who died from 1968 to 1973, we analyzed the effect of military service in the Republic of Vietnam on testicular pathology. Among 1,048 MWDs that died in Vietnam and had no reported developmental risk factors for testicular disease, significant excesses of testicular hemorrhage, epididymitis/orchitis, sperm granuloma, testicular degeneration, and seminoma were evident. Among 126 MWDs with prior Vietnam service who died at other duty stations outside Vietnam from 1968 to 1973, significant excesses of testicular degeneration and seminoma were likewise evident. Among 136 MWDs with prior Vietnam service that later died from 1974 to 1980, seminoma continued to be diagnosed in significant excess. In each instance, the odds ratio for the association between Vietnam service and seminoma was 2.0 or greater. Analysis of ever service by Corps Tactical Zones showed significant excesses of seminoma with ...

1995-05-01

303

The Prognostic Significance of p53, Bcl-2, Cytokeratin 20 and Ki-67 in Primary Superficial Papillary Transitional Bladder Carcinoma

Purpose: To evaluate the therapeutic effect of heated (60 deg. C) lipiodol via hepatic artery administration in a rabbit model of VX2 liver cancer. Materials and methods: Thirty male New Zealand white rabbits were randomly divided into three groups with 10 rabbits assigned to each group. VX2 carcinoma cells were surgically implanted into the left hepatic lobe. The tumors were allowed to grow for 2 weeks, and studies were performed until the diameter of the tumors detected by ultrasonograph reached 2-3 cm. Under anesthesia, trans-catheter hepatic arterial embolization was performed and doxorubicin-lipiodol (37 deg. C) (1 mL), lipiodol (60 deg. C) (1 mL) or control (physiological saline (37 deg. C) (1 mL)) solution was injected into the hepatic arteries of animals in the three groups. One week later, the volume of the tumor was measured by ultrasonograph again. The serum of all rabbits was collected before injection and at 4 and 7 days after injection, and the level ...

2010-02-15

304

Sequence analysis of the ATM gene in 20 patients with RTOG grade 3 or 4 acute and/or late tissue radiation side effects

Identification of factors that determine individual patient risk for recurrence and progression in superficial papillary carcinoma of the bladder is a subject of extensive research as it would be a major outcome in patient management. It has been well recognized that traditional prognostic markers as tumor grade and stage are not accurate enough in predicting biological behavior. A large number of markers have been investigated as potential prognostic factors and relatively few can help in predicting outcome. Material and Methods: Forty-nine cases undergoing complete transurethral resection for primary superficial papillary transitional cell carcinoma were subjected to clinicopathologic evaluation as well as immunohistochemical staining for p53, bcl-2, cytokeratin 20 and Ki-67. The CAS-200 image analyzer was used to estimate the Ki-67 labeling index. Results: Recurrence was observed in 19 cases (38.8%) and progression in 7 cases (14.3%) with a median followup of 49 months (range 24-84 ...

2003-03-01

305

Is uniform target dose possible in IMRT plans in the head and neck?

Purpose: Patients with ataxia-telangiectasia (A-T) show greatly increased radiation sensitivity and cancer predisposition. Family studies imply that the otherwise clinically silent heterozygotes of this autosomal recessive disease run a 3.5 to 3.8 higher risk of developing cancer. In vitro studies suggest moderately increased cellular radiation sensitivity of A-T carriers. They may also show elevated clinical radiosensitivity. We retrospectively examined patients who presented with severe adverse reactions during or after standard radiation treatment for mutations in the gene responsible for A-T, ATM, considering a potential means of future identification of radiosensitive individuals prospectively to adjust dosage schedules. Material and Methods: We selected 20 cancer patients (breast, 11; rectum, 2; ENT, 2; bladder, 1; prostate, 1; anus, 1; astrocytoma, 1; Hodgkins lymphoma, 1) with Grade 3 to 4 (RTOG) acute and/or late tissue radiation side effects by reaction severity. DNA from the ...

1999-07-15

306