yfact pob3-m domain: Topics by WorldWideScience.org

A genome-wide study of PDZ-domain interactions in C. elegans reveals a high frequency of non-canonical binding

Not Available

2011-05-01

3

PAS Domain Residues Involved in Signal Transduction by the Aer Redox Sensor of Escherichia coli

BackgroundProteins may evolve through the recruitment and modification of discrete domains, and in many cases, protein action can be dissected at the domain level. PDZ domains are...Full Text Available

4

Genome-wide profiling of forum domains in Drosophila melanogaster

SummaryPAS domains sense oxygen, redox potential and light, and are implicated in behavior, circadian rhythmicity, development and metabolic regulation. Although PAS domains are...Full Text Available

2000-05-01

5

A hypothetical model for the peptide binding domain of hsp70 based on the peptide binding domain of HLA.

Forum domains are stretches of chromosomal DNA that are excised from eukaryotic chromosomes during their spontaneous non-random fragmentation. Most forum domains are 50–200 kb in length....Full Text Available

2011-05-01

6

Some proposed relations among the domains of behavior analysis

The sequences of the peptide binding domains of 33 70 kd heat shock proteins (hsp70) have been aligned and a consensus secondary structure has been deduced. Individual members showed no significant...Full Text Available

1991-05-01

7

Collaborative systems and multiagent systems

The present article examines the nature of and relations among the domains of behavior analysis. It first proposes a set of annotated, descriptive criteria to aid in distinguishing the experimental...Full Text Available

2003-01-01

8

Suppression of Magnetization Ringing After Domain Wall Collision Studied by Micromagnetic Simulation

This paper presents some basic elements regarding the domain of the collaborative systems, a domain of maximum actuality and also the multiagent systems, developed as a result of a sound study on the one-agent systems.

2009-01-01

9

KoreaScience (Korea)

Full Text Available

2008-12-01

10

NMR assignment of the cAMP-binding domain A of the PKA regulatory subunit

Domain Bridging Interactions. A Necessary Contribution to the Function and Structure of 'Escherichia coli' Aspartate Transcarbamoylase

No abstract prepared.

2006-12-15

11

Direct Time Domain Method for Nonlinear Earthquake Response Analysis of Dam-Reservoir Systems

No abstract prepared.

2001-01-01

12

KoreaScience (Korea)

Full Text Available

2010-06-01

13

Gravitational Waves from Collapsing Domain Walls

A study on the relation between linguistics-oriented and domain-specific semantics

We study the production of gravitational waves from cosmic domain walls created during phase transition in the early universe. We investigate the process of formation and evolution of domain walls by running three dimensional lattice simulations. If we introduce an approximate discrete symmetry, walls become metastable and finally disappear. We calculate the spectrum of gravitational waves produced by collapsing metastable domain walls. Extrapolating the numerical results, we find the signal of gravitational waves produced by domain walls whose energy scale is around 10^10-10^12GeV will be observable in the next generation gravitational wave interferometers.

2010-01-01

14

Functional domain analysis of glass, a zinc-finger-containing transcription factor in Drosophila.

In this paper we dealt with the comparison and linking between lexical resources with domain knowledge provided by ontologies. It is one of the issues for the combination of the Semantic Web Ontologies and Text Mining. We investigated the relations between the linguistics oriented and domain-specific semantics, by associating the GO biological process concepts to the FrameNet semantic frames. The result shows the gaps between the linguistics-oriented and domain-specific semantics on the classification of events and the grouping of target words. The result provides valuable information for the improvement of domain ontologies supporting for text mining systems. And also, it will result in benefits to language understanding technology.

2010-01-01

15

The human peripheral subunit-binding domain folds rapidly while overcoming repulsive Coulomb forces

The glass gene is required for proper photo-receptor differentiation during development of the Drosophila eye glass codes for a DNA-binding protein containing five zinc fingers that we show is a transcriptional activator. A comparison of the sequences of the glass genes from two species of Drosophila and a detailed functional domain analysis of the Drosophila melanogaster glass gene reveal that both the DNA-binding domain and the transcriptional-activation domain are highly conserved between the two species. Analysis of the DNA-binding domain of glass indicates that the three carboxyl-terminal zinc fingers alone are necessary and sufficient for DNA binding. We also show that a deletion mutant of glass containing only the DNA-binding domain can behave in a dominant-negative manner both in vivo and in a cell culture assay that measures transcriptional activation. PMID:7604032

1995-07-01

16

Structure of the Taz2 domain of p300: insights into ligand binding

Peripheral subunit binding domains (PSBDs) are integral parts of large multienzyme complexes involved in carbohydrate metabolism. PSBDs facilitate shuttling of prosthetic groups between different catalytic...Full Text Available

2010-09-01

17

Structural formulae for some classes of analytic functions in a finitely connected domain

CBP and its paralog p300 are histone acetyl transferases that regulate gene expression by interacting with multiple transcription factors via specialized domains. The structure...Full Text Available

2009-12-01

18

Solution structure of two molecular motor domains: nonclaret disjunctional and kinesin.

Several central results of the method of structural formulae for some classes of analytic functions, which were known before for a disc and an annulus, are generalized to analytic functions in a finitely connected circular domain.

1997-12-01

19

ReplicationDomain: a visualization tool and comparative database for genome-wide replication timing data

The effects of selected ligands on the structure of the truncated heavy-chain chemomechanical motor domains of Drosophila ncd and human kinesin were compared using the technique of transient electric...Full Text Available

1995-04-01

20

Rearrangement of a common cellular DNA domain on chromosome 4 in human primary liver tumors.

BackgroundEukaryotic DNA replication is regulated at the level of large chromosomal domains (0.5–5 megabases in mammals) within which replicons are activated relatively synchronously....Full Text Available

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

21

Novel structural features in two ZHX homeodomains derived from a systematic study of single and multiple domains

Hepatitis B virus (HBV) DNA integration has been shown to occur frequently in human hepatocellular carcinomas. We have investigated whether common cellular DNA domains might be rearranged, possibly...Full Text Available

1988-02-01

22

Initial Report of the Cancer PROMIS Supplement Sexual Function Committee: Review of Sexual Function Measures and Domains Used in Oncology

BackgroundZhx1 to 3 (zinc-fingers and homeoboxes) form a set of paralogous genes encoding multi-domain proteins. ZHX proteins consist of two zinc fingers followed...Full Text Available

23

Fourth Order Accurate Discretization for the Laplace and Heat Equations on Arbitrary Domains, with Applications to the Stefan Problem.

ObjectiveThis report describes initial activities of the Cancer Patient-Reported Outcomes Measurement Information System (PROMIS) Sexual Function domain group (CaPS-SF),...Full Text Available

2009-03-15

24

Dimeric subunit stoichiometry of the human voltage-dependent proton channel Hv1

In this paper, the authors first describe a fourth order accurate finite difference discretization for both the Laplace equation and the heat equation with Dirichlet boundary conditions on irregular domains. In the case of the heat equation, they use an i...

2004-01-01

25

Comparative Structural Analysis of Lipid Binding START Domains

In voltage-gated Na⁺, K⁺, and Ca²⁺ channels, four voltage-sensor domains operate on a central pore domain in response to membrane voltage. In contrast, the voltage-gated...Full Text Available

2008-06-03

26

Clinical Assessment of Mirror Artifacts in Spectral-Domain Optical Coherence Tomography

BackgroundSteroidogenic acute regulatory (StAR) protein related lipid transfer (START) domains are small globular modules that form a cavity where lipids and lipid hormones bind....Full Text Available

27

Automated 3-D method for the correction of axial artifacts in spectral-domain optical coherence tomography images

Purpose.To investigate the characteristics of a spectral-domain optical coherence tomography (SD-OCT) image phenomenon known as the mirror artifact, calculate its prevalence, analyze...Full Text Available

2010-07-01

28

Antibodies to synthetic peptides from the tubulin regulatory domain interact with tubulin and microtubules.

The 3-D spectral-domain optical coherence tomography (SD-OCT) images of the retina often do not reflect the true shape of the retina and are distorted differently along the x and y...Full Text Available

29

The Calculation and Measurement of Flexural and ...

The carboxyl-terminal region of tubulin alpha and beta subunits plays a major role in regulating its assembly into microtubules and constitutes an essential domain for the selective interaction of microtubule-associated...Full Text Available

1988-09-01

30

Study on the Surface Magnetic Domain Structure of Thin-Gauged 3% Si-Fe Strips using Scanning Electron Microscopy with Polarization Analysis

... Verheij (1980) described how the frequency domain could be exploited using cross spectral density measurements to measure the flexural ...

1996-02-01

31

KoreaScience (Korea)

Full Text Available

1998-06-01

32

Nanometer size determination of type II domains in CuPt-ordered GaInP2 with high-pressure magneto-luminescence.

Intelligent Analyst Digital Video Library Prototype

No abstract prepared.

1999-12-31

33

The YTH Domain Is a Novel RNA Binding Domain*

... type. Sonic's digital libraries will provide a cross mapping between the narrative (speech and text) and imagery domains. ...

2002-10-01

34

The Na⁺/H⁺ Exchanger NHE6 in the Endosomal Recycling System Is Involved in the Development of Apical Bile Canalicular Surface Domains in HepG2 Cells

The YTH (YT521-B homology) domain was identified by sequence comparison and is found in 174 different proteins expressed in eukaryotes. It is characterized by 14 invariant residues within an α-helix/β-sheet...Full Text Available

2010-05-07

35

Structural Chemistry of Human SET Domain Protein Methyltransferases

Polarized epithelial cells develop and maintain distinct apical and basolateral surface domains despite a continuous flux of membranes between these domains. The Na⁺/H⁺exchanger...Full Text Available

2010-04-01

36

Domain structure of ferrite-garnet crystalline plates (111) with uniaxial anisotropy

There are about fifty SET domain protein methyltransferases (PMTs) in the human genome, that transfer a methyl group from S-adenosyl-L-methionine (SAM) to substrate lysines on histone tails or other peptides. A number of structures in complex with cofactor, substrate, or inhibitors revealed the mechanisms of substrate recognition, methylation state specificity, and chemical inhibition. Based on these structures, we review the structural chemistry of SET domain PMTs, and propose general concepts towards the development of selective inhibitors.

2011-08-22

37

UHRF1, a modular multi-domain protein, regulates replication-coupled crosstalk between DNA methylation and histone modifications

Magnetic field, thickness and magnetic forming effect on general mode and quantitative parameters of the domain structure (DS) of ferrite-garnet (EuEr)/sub 3/(FeGa)/sub 5/O/sub 12/ monocrystalline plates (111) is investigated. Field interval of circle (cone) and ring domain stability is determined. It is shown that DS of ferrite-garnet crystals with uniaxial an6sotropy has some peculiarities, that can be explained by cubic anisotropy effect.

1982-03-01

38

Time-domain dynamic opto-rheology study of polymer films using step-scan FTIR time-resolved spectroscopy (S{sup 2}FTIR TRS)

Cytosine methylation in DNA is a major epigenetic signal, and plays a central role in propagating chromatin status during cell division. However the mechanistic links between DNA methylation and histone methylation are poorly understood. A multi-domain protein UHRF1 (ubiquitin-like, containing PHD and RING finger domains 1) is required for DNA CpG maintenance methylation at replication forks, and mouse UHRF1-null cells show enhanced susceptibility to DNA replication arrest and DNA damaging agents. Recent data demonstrated that the SET and RING associated (SRA) domain of UHRF1 binds hemimethylated CpG and flips 5-methylcytosine out of the DNA helix, whereas its tandom tudor domain and PHD domain bind the tail of histone H3 in a highly methylation sensitive manner. We hypothesize that UHRF1 brings the two components (histones and DNA) carrying appropriate markers (on the tails of H3 ...

2009-01-01

39

Magnetization reversal phenomena and domain wall behaviours in nanostructured magnetic systems

Step-scan Fourier transform infrared spectroscopy in conjunction with impulse stress on polymer films has been used to monitor dynamic rheological responses in real time. A novel piezo-electrically-driven polymer microrheometer was employed to apply repetitive impulses to the polymer sample while time-domain spectra were recorded. Recent results include the study of both semi-crystalline polymers such as isotactic polypropylene (iPP) and elastomers such as Estane polyester/polyurethane copolymer and Kraton tri-block copolymer. The spectral changes of iPP are consistent with frequency-domain results. For iPP at room temperature, large differences in the response times of different absorption bands are not seen. However, the orientation response of the CH{sub 3} rocking mode is slightly slower than the responses of the backbone modes. To the authors` knowledge, this is the first reported successful step-scan FTIR time-domain ...

1998-07-01

40

Creation of an antiferromagnetic exchange spring

Several recent experiments on micro- (or nano-) structured samples of ferromagnetic materials are introduced. Magnetization reversal phenomena are investigated on submicron wire samples of trilayer structure using the giant magnetoresistance effect. Domain wall movements are sensitively monitored by resistivity measurements and the velocity of propagation is determined. The contribution of domain wall to the resistivity is argued from the results on artificially designed samples of a spring-magnet system. In circular dots of permalloy, the existence of vortex magnetization is confirmed and the reversal of the vortex core magnetization is studied from magnetic force microscopy measurements. (author)

2001-09-23

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

41

Wave extrapolation in the spatial wavelet domain with application to poststack reverse-time migration

We present evidence for the creation of an exchange spring in an antiferromagnet due to exchange coupling to a ferromagnet. X-ray magnetic linear dichroism spectroscopy on single crystal Co/NiO(001) shows that a partial domain wall is wound up at the surface of the antiferromagnet when the adjacent ferromagnet is rotated by a magnetic field. We determine the interface exchange stiffness and the antiferromagnetic domain wall energy from the field dependence of the direction of the antiferromagnetic axis, the antiferromagnetic pendant to a ferromagnetic hysteresis loop. The existence of a planar antiferromagnetic domain wall, proven by our measurement, is a key assumption of most exchange bias models.

2004-04-06

42

The influence of tertiary structural restraints on conformational transitions in superhelical DNA.

A wavelet transformation is performed over each of the spatial coordinates of the scalar wave equation. This transformed equation is solved directly with a finite-difference scheme for both homogeneous and smooth inhomogeneous media. Wavefield extrapolation is performed completely in the spatial wavelet domain without transforming back into the space domain at each time step. The wavelet coefficients are extrapolated, rather than the wavefield itself. The numerical solution of the scalar wave equation in the spatial wavelet domain is closely related to the finite-difference method because of the compact support of the wavelet bases. Poststack reverse-time migration is implemented as an application. The resolution spaces of the wavelet transform provide a natural framework for multigrid analysis. Migrated images are constructed from various resolution spaces.

1998-03-01

43

Telomeres in cancer and ageing

This paper examines theoretically the effects that restraints on the tertiary structure of a superhelical DNA domain exert on the energetics of linking and the onset of conformational transitions. The...Full Text Available

1987-12-10

44

Supersaturation of antiferromagnetically coupled multilayers: A comparative polarised neutron reflectometry study

Telomeres protect the chromosome ends from unscheduled DNA repair and degradation. Telomeres are heterochromatic domains composed of repetitive DNA (TTAGGG repeats) bound to an array of specialized...Full Text Available

2011-01-12

45

Research of time-domain equivalent circuit method in solving dispersion of coupled-cavity traveling-wave tube

Reflectometric methods like polarised neutron reflectometry (PNR) and synchrotron Moessbauer reflectometry (SMR) are capable of investigating the plane-perpendicular and lateral magnetic structure of multilayers (MLs). Previously, a variety of domain formation and transformation phenomena was found and systematically studied in a Fe/Cr ML of strong antiferromagnetic coupling by PNR and SMR. Growth of the primary domains on passing the bulk-spin-flop transition was established. The domains were found to revert to their native state only in a field considerably higher than the apparent saturation field, a phenomenon referred to as the supersaturation domain memory effect (SDME). We present a comparative PNR study of two antiferromagnetically coupled Fe/Cr MLs with different magnetisation curves. We show that the distribution of the layer-layer coupling rather than the magnetic structure of the Cr spacer ...

2007-07-15

46

Magnetohydrodynamic structure of a plasmoid in fast ... - NASA

In this paper, a time-domain equivalent circuit method is applied to solve dispersion of coupled-cavity travelling-wave tube (CCTWT). First, the time-domain circuit equations of CCTWT coupled-cavity chain are deduced from the equivalent circuit model. Then, the equations are solved numerically by fourth-order Runge-Kutta method and a program CTTDCP is developed using MATLAB. Last, a L-band CCTWT is calculated using CTTDCP and the cavity pass-band of this tube is computed to be 1.08-1.48 GHz, which is consistent with the experimental results and the simulation results of electromagnetic code and demonstrates the validity of the time-domain equivalent circuit method. In addition, a new design method which uses the equivalent circuit method and electromagnetic simulation together to optimize the cold cavity characteristics of CCTWT is proposed. (authors)

2008-09-01

47

Frequency-Domain Optical Mammogram

We set a symmetric boundary at x=200 and a conducting wall at z=150. The domain of 0200. 0150 is resolved by 60004500 grid cells. Harris sheet ...

48

Fractional domain walls from on-site softening in dipolar bosons

... where i is the wavelength index (ranging from 1 to 4), while Esb and FHb02 are the molar extinction coefficients of deoxy-hemoglobin and oxy ...

2002-10-01

49

Characterization of radon penetration of different structural domains of concrete. Final project report

We study dipolar bosons in a 1D optical lattice and identify a region in parameter space---strong coupling but relatively weak on-site repulsion---hosting a series of stable CDW states whose low-energy excitations, built from "fractional domain walls", are remarkably similar to those of non-abelian fractional quantum Hall states. Here, a conventional domain wall between translated CDW's may split by inserting strings of degenerate, but inequivalent, CDW states. Outside these insulating regions, we find numerous supersolids as well as a superfluid regime. The mentioned phases should be accessible experimentally, and in particular, the fractional domain walls can be created in the ground state using single-site addressing, i.e. by locally changing the chemical potential.

2011-01-01

50

Characterization of and Concepts for Metroplex Operations

This report documents the research activities by Rogers and Associates Engineering Corporation on grant DE-FG03-93ER61600 during the funded project period from August 1993 to April 1996. The objective of this research was to characterize the mechanisms and rates of radon gas penetration of the different structural domains of the concrete components of residential floor slabs, walls, and associated joints and penetrations. The research was also to characterize the physical properties of the concretes in these domains to relate their radon resistance to their physical properties. These objectives support the broader goal of characterizing which, if any, concrete domains and associated properties constitute robust barriers to radon and which permit radon entry, either inherently or in ways that could be remediated or avoided.

51

Bayesian models for multiple outcomes nested in domains

7.5.6 Conclusions of the Generic Metroplex Queueing Simulation . ...... the systemwide arrival delays incurred at the metroplex terminal-area ...... assignment rules, estimated nominal transit speeds or times by domain, and stochastic ...

52

Assignment of the {sup 1}H, {sup 15}N and{sup 13} C resonances of the calcium-free and calcium-bound forms of the first C{sub 2}-domain of synaptotagmin I

SummaryWe consider the problem of estimating the effect of exposure on multiple continuous outcomes, when the outcomes are measured on different scales and are nested within multiple...Full Text Available

2009-12-01

53

Aeroelastic Analysis by Coupled Non-linear Time Domain ... - NASA

No abstract prepared.

1997-10-15

54

Rin-like, a novel regulator of endocytosis, acts as guanine nucleotide exchange factor for Rab5a and Rab22

and shock induced flow separation may significantly affect the flutter ...... Aerodynamic and Aeroelastic Simulation, AGARD Report 822, 10-1 10-20. ...

55

Numerical methods for determining the inhomogeneity boundary in a boundary value problem for Laplace?s equation in a piecewise homogeneous medium

RIN proteins serve as guanine nucleotide exchange factors for Rab5a. They are characterized by the presence of a RIN homology domain and a C-terminal Vps9 domain. Currently three family members have...Full Text Available

2011-06-01

56

British Library Electronic Table of Contents (United Kingdom)

A boundary value problem for Laplace?s equation in a bounded two-dimensional domain filled with a piecewise homogeneous medium is considered. The boundary of the inhomogeneity is assumed to be unknown. The inverse problem of determining the inhomogeneity boundary and the solution of the equation given the solution and its normal derivative on the boundary of the domain is discussed. Numerical methods are proposed for solving the inverse problem, and the results of numerical experiments are presented.

2011-01-01

57

Mutations Affecting Motifs of Unknown Function in the Central Domain of Nitrogen Regulatory Protein C

Magnetic domains in martensite of Ni-Mg-Ga alloy

The positive control function of the bacterial enhancer-binding protein NtrC resides in its central domain, which is highly conserved among activators of ς⁵⁴ holoenzyme. Previous...Full Text Available

1999-09-01

58

Hepatitis C Virus RNA Replication Requires a Conserved Structural Motif within the Transmembrane Domain of the NS5B RNA-Dependent RNA Polymerase ?

The structural changes attendant on intermartensitic transformation in a Ni-Mg-Ga shape memory alloy are considered using magneto-optical visualization with the help of ferrite-garnet monocrystalline films. It is established that on the intermartensitic transformation the complete reorganization of martensite macrostructure fails. Martensite crystals resulted from the basic transformation change somewhat their sizes on intermartensitic transition. The existence of large-scale labyrinth magnetic domain structure is revealed

2006-05-01

59

Cauchy problem for the Mathieu equation away from parametric resonance

Hepatitis C virus (HCV) nonstructural protein 5B (NS5B), the viral RNA-dependent RNA polymerase (RdRp), is a tail-anchored protein with a highly conserved C-terminal transmembrane domain (TMD) that...Full Text Available

2010-11-01

60

British Library Electronic Table of Contents (United Kingdom)

Four solutions of the Cauchy problem for Mathieu?s equation away from parametric resonance domains are analytically constructed using an asymptotic averaging method in the fourth approximation. Three solutions occur near fractional parameter values at which slow combination phases exist. The fourth solution occurs in the absence of slow phases away from parametric resonance domains and the fractional parameter values.

2011-01-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

61

Lipid domain formation modulates activities of snake venom phospholipase A(2) enzymes.

Accident knowledge and emergency management

The goal of the present study is to elucidate the effect of lipid domain formation on activities of Naja naja atra and Bungarus multicinctus phospholipase A(2) (PLA(2)) enzymes. Sphingomyelin inhibited enzymatic activity and membrane-damaging activity of PLA(2) against egg yolk phosphatidylcholine (EYPC), while cholesterol and cholesterol sulfate abrogated the inhibitory effect of sphingomyelin. The ability of cholesterol and cholesterol sulfate to abolish the inhibitory effect of sphingomyelin was closely related to their capacity to induce domain formation in EYPC/sphingomyelin vesicles. Laurdan fluorescence measurement revealed that membrane packing of EYPC/sphingomyelin vesicles was differently affected by cholesterol and cholesterol sulfate. Unlike cholesterol, cholesterol sulfate was unable to promote domain formation in dipalmitoylphosphatidylcholine (DPPC) vesicles. Cholesterol increased but cholesterol sulfate ...

2010-08-10

62

Field driven ferromagnetic phase evolution originating from the domain boundaries in antiferromagnetically coupled perpendicular anitsotropy films

The report contains an overall frame for transformation of knowledge and experience from risk analysis to emergency education. An accident model has been developed to describe the emergency situation. A key concept of this model is uncontrolled flow of energy (UFOE), essential elements are the state, location and movement of the energy (and mass). A UFOE can be considered as the driving force of an accident, e.g., an explosion, a fire, a release of heavy gases. As long as the energy is confined, i.e. the location and movement of the energy are under control, the situation is safe, but loss of confinement will create a hazardous situation that may develop into an accident. A domain model has been developed for representing accident and emergency scenarios occurring in society. The domain model uses three main categories: status, context and objectives. A domain is a group of activities with allied goals and elements and ten ...

1997-03-01

63

Students' general and physics epistemological beliefs: a twofold phenomenon

Strong perpendicular anisotropy systems consisting of Co/Pt multilayer stacks that are antiferromagnetically coupled via thin Ru or NiO layers have been used as model systems to study the competition between local interlayer exchange and long-range dipolar interactions [1,2]. Magnetic Force Microscopy (MFM) studies of such systems reveal complex magnetic configurations with a mix of antiferromagnetic (AF) and ferromagnetic (FM) phases. However, MFM allows detecting surface stray fields only and can interact strongly with the magnetic structure of the sample, thus altering the original domain configuration of interest [3,4]. In the current study they combine magnetometry and state-of-the-art soft X-ray transmission microscopy (MXTM) to investigate the external field driven FM phase evolution originating from the domain boundaries in such antiferromagnetically coupled perpendicular anisotropy films. MXTM allows directly imaging the perpendicular ...

2008-05-01

64

British Library Electronic Table of Contents (United Kingdom)

Background: Although research on epistemological beliefs has expanded over the past two decades, there are still some issues that need to be explored, such as whether epistemological beliefs are domain general or domain specific. Purpose: One of the purposes of this research was to determine if high school students' general epistemological beliefs were different from their epistemological beliefs in the domain of physics. Sample: The research was conducted with 15 grade nine students studying in an urban all-boys school. Their average age was 16. Their previous school experiences were traditional oriented. Design and methods: A case study design with qualitative methods was used for the research. Two questionnaires were developed and used in semi-structured interview protocols two times, w...

2011-01-01

65

Numerical evaluation of effective unsaturated hydraulic properties for fractured rocks

Mechanism of Dephosphorylation of the SR Protein ASF/SF2 by Protein Phosphatase 1

To represent a heterogeneous unsaturated fractured rock by its homogeneous equivalent, Monte Carlo simulations are used to obtain upscaled (effective) flow properties. In this study, we present a numerical procedure for upscaling the van Genuchten parameters of unsaturated fractured rocks by conducting Monte Carlo simulations of the unsaturated flow in a domain under gravity-dominated regime. The simulation domain can be chosen as the scale of block size in the field-scale modeling. The effective conductivity is computed from the steady-state flux at the lower boundary and plotted as a function of the averaging pressure head or saturation over the domain. The scatter plot is then fitted using van Genuchten model and three parameters, i.e., the saturated conductivity K{sub s}, the air-entry parameter {alpha}, the pore-size distribution parameter n, corresponding to this model are considered as the effective K{sub s}, ...

2009-01-01

66

British Library Electronic Table of Contents (United Kingdom)

SR proteins are essential splicing factors whose function is controlled by multi-site phosphorylation of a C-terminal domain rich in arginine-serine repeats (RS domain). The protein kinase SRPK1 has been shown to polyphosphorylate the N-terminal portion of the RS domain (RS1) of the SR protein ASF/SF2, a modification that promotes nuclear entry of this splicing factor and engagement in splicing function. Later, dephosphorylation is required for maturation of the spliceosome and other RNA processing steps. While phosphates are attached to RS1 in a sequential manner by SRPK1, little is known about how they are removed. To investigate factors that control dephosphorylation, we monitored region-specific mapping of phosphorylation sites in ASF/SF2 as a function of the protein phosphatase PP1. W...

2010-01-01

67

Knowledge Encapsulation Framework for Collaborative Social Modeling

Insight into Thyroid-Stimulating Autoantibody Interaction with the Thyrotropin Receptor N-Terminus Based on Mutagenesis and Re-Evaluation of Ambiguity in This Region of the Receptor Crystal Structure

This paper describes the Knowledge Encapsulation Framework (KEF), a suite of tools to enable knowledge inputs (relevant, domain-specific facts) to modeling and simulation projects, as well as other domains that require effective collaborative workspaces for knowledge-based task. This framework can be used to capture evidence (e.g., trusted material such as journal articles and government reports), discover new evidence (covering both trusted and social media), enable discussions surrounding domain-specific topics and provide automatically generated semantic annotations for improved corpus investigation. The current KEF implementation is presented within a wiki environment, providing a simple but powerful collaborative space for team members to review, annotate, discuss and align evidence with their modeling frameworks. The novelty in this approach lies in the combination of automatically tagged and user-vetted resources, ...

2009-03-24

68

British Library Electronic Table of Contents (United Kingdom)

Background: Thyroid-stimulating autoantibodies (TSAb) bind to the thyrotropin receptor (TSHR) extracellular domain, or ectodomain (ECD), comprising a leucine-rich repeat domain (LRD) linked by a hinge region to the transmembrane domain (TMD). The LRD (residues 22???260; signal peptide 1???21) contains two disulfide-bonded loops at its N-terminus. In the crystal structure of the isolated LRD complexed with human TSAb monoclonal antibody (mAb) M22, N-terminal disulfide loop 1 (residues 22???30) could not be determined because of crystal disorder. Nevertheless, present crystal structure data are interpreted to exclude a role for the LRD N-terminal disulfide loops in the TSAb epitope(s), contradicting prior functional evidence of a role for these loops in TSAb function. Materials and Methods: ...

2011-01-01

69

Extracting mining subsidence land from remote sensing images based on domain knowledge

Circular map for supercavitating flow in a multiply connected domain

Extracting mining subsidence land from remote sensing (RS) images is one of important research contents for environment monitoring in mining area. The accuracy of traditional extracting models based on spectral features is low. In order to extract subsidence land from RS images with high accuracy, some domain knowledge should be imported and new models should be proposed. This paper, in terms of the disadvantage of traditional extracting models, imports domain knowledge from practice and experience, converts semantic knowledge into digital information, and proposes a new model for the specific task. By selecting the Luan mining area as a study area, this new model is tested based on GIS and related knowledge. The result shows that the proposed method is more precise than traditional methods and can satisfy the demands of land subsidence monitoring in mining area. 10 refs., 4 figs., 1 tab.

2008-06-15

70

British Library Electronic Table of Contents (United Kingdom)

A nonlinear free boundary-value problem of supercavitating flow past n + 1 hydrofoils is analyzed. To describe the cavities' closure mechanism, the Tulin-Terentev single-spiral-vortex model is employed. The flow domain is considered as the image of an (n + 1)-connected circular domain. The conformal map is constructed in terms of the solutions to two Riemann-Hilbert problems of the theory of symmetric automorphic functions. One of the problems is homogeneous and its coefficients are continuous functions while the second problem is inhomogeneous and has discontinuous coefficients. The exact solutions to the problems are found by using quasiautomorphic and quasimultiplicative analogs of the Cauchy kernel. The case of a single plate is considered in detail and the numerical results are report...

2009-01-01

71

Bacteriophage P22 capsid size determination: Roles for the coat protein telokin-like domain and the scaffolding protein amino-terminus

British Library Electronic Table of Contents (United Kingdom)

Assembly of icosahedral capsids of proper size and symmetry is not understood. Residue F170 in bacteriophage P22 coat protein is critical for conformational switching during assembly. Substitutions at this site cause assembly of tubes of hexamerically arranged coat protein. Intragenic suppressors of the ts phenotype of F170A and F170K coat protein mutants were isolated. Suppressors were repeatedly found in the coat protein telokin-like domain at position 285, which caused coat protein to assemble into petite procapsids and capsids. Petite capsid assembly strongly correlated to the side chain volume of the substituted amino acid. We hypothesize that larger side chains at position 285 torque the telokin-like domain, changing flexibility of the subunit and intercapsomer contacts. Thus, a sing...

2011-01-01

72

A multidimensional hybrid intelligent method for gear fault diagnosis

British Library Electronic Table of Contents (United Kingdom)

Identifying gear damage categories, especially for early faults and combined faults, is a challenging task in gear fault diagnosis. This paper proposes a new multidimensional hybrid intelligent diagnosis method to identify different categories and levels of gear damage automatically. In this method, Hilbert transform, wavelet packet transform (WPT) and empirical mode decomposition (EMD) are performed on gear vibration signals to extract additional fault characteristic information. Then, multidimensional feature sets including time-domain, frequency-domain and time-frequency-domain features are generated to reveal gear health conditions. Multiple classifiers based on several classification algorithms and input features are combined with genetic algorithm (GA). Because of the use of multidim...

2010-01-01

73

lib_general.pro - ECCO2

Variable domain I of nematode CLEs directs post-translational targeting of CLE peptides to the extracellular space

Returns singular values (sigma), ;left field (x) vectors, ..... n) do begin point=ngbrs(i) if (point+tau le nt-1) then begin if (x(point+tau,0) ne q) then .... ;FILTER ;applies a gaussian filter in the frequency domain function filter, x ...

74

Unexpected diversity of RNase P, an ancient tRNA processing enzyme: challenges and prospects

Effector proteins expressed in the esophageal gland cells of cyst nematodes are delivered into plant cells through a hollow, protrusible stylet. Although evidence indicates that effector proteins function...Full Text Available

2010-12-01

75

UHRF1, a modular multi-domain protein, regulates replication-coupled crosstalk between DNA methylation and histone modifications

For an enzyme functioning predominantly in a seemingly housekeeping role of 5′ tRNA maturation, RNase P displays a remarkable diversity in subunit make-up across the three domains of...Full Text Available

2010-01-21

76

Two separate domains within vesicular stomatitis virus phosphoprotein support transcription when added in trans.

Cytosine methylation in DNA is a major epigenetic signal, and plays a central role in propagating chromatin status during cell division. However the mechanistic links between DNA methylation...Full Text Available

2009-01-01

77

The opening of the two pores of the Hv1 voltage-gated proton channel is tuned by cooperativity

The structural phosphoprotein NS of vesicular stomatitis virus, in association with the virion-associated RNA polymerase L protein, transcribes the genome ribonucleoprotein template in vitro. It contains...Full Text Available

1987-12-01

78

The dimerization domain of SOX9 is required for transcription activation of a chondrocyte-specific chromatin DNA template

SUMMARYIn voltage-gated sodium, potassium, and calcium channels the functions of ion conduction and voltage sensing are performed by two distinct structural units: the pore domain...Full Text Available

2010-01-01

79

The chromosomal association/dissociation of the chromatin insulator protein Cp190 of Drosophila melanogaster is mediated by the BTB/POZ domain and two acidic regions

Mutations in SOX9, a gene essential for chondrocyte differentiation cause the human disease campomelic dysplasia (CD). To understand how SOX9 activates transcription, we characterized...Full Text Available

2010-10-01

80

The Zinc Finger SET Domain Gene Prdm14 Is Overexpressed in Lymphoblastic Lymphomas with Retroviral Insertions at Evi32

BackgroundChromatin insulators or boundary elements are a class of functional elements in the eukaryotic genome. They regulate gene transcription by interfering with promoter-enhancer...Full Text Available

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

81

The Transition to High School: Current Knowledge, Future Directions

BackgroundAKXD recombinant inbred strains of mice have proven to be very useful in the identification of potential oncogenes and tumor suppressors involved in the development of...Full Text Available

82

The Structure of Sucrose Phosphate Synthase from Halothermothrix orenii Reveals Its Mechanism of Action and Binding Mode

In the American educational system, school transitions are frequent and predictable, but they can disrupt student functioning across developmental domains. How students experience school transitions...Full Text Available

2011-04-01

83

The Hippo tumor-suppressor pathway regulates apical-domain size in parallel to tissue growth

Sucrose phosphate synthase (SPS) catalyzes the transfer of a glycosyl group from an activated donor sugar, such as uridine diphosphate glucose (UDP-Glc), to a saccharide acceptor D-fructose 6-phosphate (F6P), resulting in the formation of UDP and D-sucrose-6'-phosphate (S6P). This is a central regulatory process in the production of sucrose in plants, cyanobacteria, and proteobacteria. Here, we report the crystal structure of SPS from the nonphotosynthetic bacterium Halothermothrix orenii and its complexes with the substrate F6P and the product S6P. SPS has two distinct Rossmann-fold domains with a large substrate binding cleft at the interdomain interface. Structures of two complexes show that both the substrate F6P and the product S6P bind to the A-domain of SPS. Based on comparative analysis of the SPS structure with other related enzymes, the donor substrate, nucleotide diphosphate glucose, binds to the ...

2008-01-01

84

Temperature-induced opening of TRPV1 ion channel is stabilized by the pore domain

SummaryThe Hippo tumor-suppressor pathway controls tissue growth in Drosophila and mammals by regulating cell proliferation and apoptosis. The Hippo pathway includes...Full Text Available

2009-07-15

85

Tarantula Huwentoxin-IV Inhibits Neuronal Sodium Channels by Binding to Receptor Site 4 and Trapping the Domain II Voltage Sensor in the Closed Configuration*S?

SummaryTRPV1 is the founding and best-studied member of the family of temperature-activated transient receptor potential ion channels (thermoTRPs). Voltage, chemicals, and heat...Full Text Available

2010-06-01

86

Symptom Burden, Depression, and Quality of Life in Chronic and End-Stage Kidney Disease

Peptide toxins with high affinity, divergent pharmacological functions, and isoform-specific selectivity are powerful tools for investigating the structure-function relationships of voltage-gated...Full Text Available

2008-10-03

87

Structure-Function Study of the N-terminal Domain of Exocyst Subunit Sec3*

Background and objectives: While many patients with end-stage renal disease (ESRD) have impaired physical and psychologic well-being, less is known about these health domains in patients with advanced...Full Text Available

2009-06-01

88

Structural Basis for Acetylated Histone H4 Recognition by the Human BRD2 Bromodomain*

The exocyst is an evolutionarily conserved octameric complex involved in polarized exocytosis from yeast to humans. The Sec3 subunit of the exocyst acts as a spatial landmark for exocytosis through...Full Text Available

2010-04-02

89

Seasonal and Spatial Variability of Bacterial and Archaeal Assemblages in the Coastal Waters near Anvers Island, Antarctica

Recognition of acetylated chromatin by the bromodomains and extra-terminal domain (BET) family proteins is a hallmark for transcriptional activation and anchoring viral genomes to mitotic chromosomes...Full Text Available

2010-03-05

90

Romantic and Sexual Relationships, Body Image, and Fertility in Adolescent and Young Adult Testicular Cancer Survivors: A Review of the Literature

A previous report of high levels of members of the domain Archaea in Antarctic coastal waters prompted us to investigate the ecology of Antarctic planktonic prokaryotes. rRNA hybridization...Full Text Available

1998-07-01

91

Rapid detection of epidermal growth factor receptor mutations with multiplex PCR and primer extension in lung cancer

This review presents a summary of existing knowledge regarding the impact of testicular cancer along four broad domains, including romantic and sexual relationships, body image, and fertility....Full Text Available

2010-08-01

92

Principle of pulse frequency measurement and methods for improving frequency meters accuracy

Epidermal growth factor receptor (EGFR) kinase domain mutations hyperactivate the kinase and confer kinase addiction of the non-small-cell lung cancer (NSCLC) tumor...Full Text Available

93

Principle of pulse frequency measurement and methods for improving frequency meters accuracy

Specificity of the pulses mean frequency measurement (the pulses being generated in a stochastic process) is described. Status of the domain of analog frequency meters is presented. Methods of increasing accuracy of such meters are discussed.

1980-01-01

94

PAS Domain of the Aer Redox Sensor Requires C-Terminal Residues for Native-Fold Formation and Flavin Adenine Dinucleotide Binding

Specificity of the pulses mean frequency measurement (the pulses being generated in a stochastic process) is described. Status of the domain of analog frequency meters is presented. Methods of increasing accuracy of such meters are discussed. (author).

1980-01-01

95

Ontological realism: A methodology for coordinated evolution of scientific ontologies

The Aer protein in Escherichia coli is a membrane-bound, FAD-containing aerotaxis and energy sensor that putatively monitors the redox state of the electron transport system. Binding...Full Text Available

2004-10-01

96

Nuclear Organization and Dynamics of 7SK RNA in Regulating Gene Expression

Since 2002 we have been testing and refining a methodology for ontology development that is now being used by multiple groups of researchers in different life science domains. Gary Merrill,...Full Text Available

2010-11-15

97

Molecular Variability of Pseudallescheria boydii, a Neurotropic Opportunist

Noncoding RNAs play important roles in various aspects of gene regulation. We have identified 7SK RNA to be enriched in nuclear speckles or interchromatin granule clusters (IGCs), a subnuclear domain...Full Text Available

2010-12-01

98

Molecular Architecture of the Centriole Proteome: The Conserved WD40 Domain Protein POC1 Is Required for Centriole Duplication and Length Control

The sequences of the internal transcribed spacer (ITS) ribosomal DNA (rDNA) domain data obtained by restriction fragment length polymorphism analysis with 18S rDNA and fingerprinting (M13) for clinical...Full Text Available

2000-09-01

99

Modular coherence of protein dynamics in yeast cell polarity system

Centrioles are intriguing cylindrical organelles composed of triplet microtubules. Proteomic data suggest that a large number of proteins besides tubulin are necessary for the formation and maintenance...Full Text Available

2009-02-15

100

Limitations of traveling wave relaying for overhead EHV transmission lines

In this study, we investigated on a systems level how complex protein interactions underlying cell polarity in yeast determine the dynamic association of proteins with the polar cortical domain (PCD)...Full Text Available

2011-05-03

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

101

Involvement of the Matrix and Nucleocapsid Domains of the Bovine Leukemia Virus Gag Polyprotein Precursor in Viral RNA Packaging

Limitations of traveling wave relaying schemes for protection of overhead extra-high voltage transmission lines are investigated. A method of analysis of traveling wave phenomena for three phase transmission lines is developed in which the interdependent phase voltages and currents are decoupled into their modal counterparts, which are approximately independent. A time domain digital simulation program is used to solve the modal transmission line equations to obtain the fault induced traveling waves detected at the relay location. The frequency dependence of the aerial modes is ignored but their losses are included. A lumped element analysis method, originally developed for transient analysis of lossy coaxial cables, is adapted here to obtain approximate solution for the fault induced traveling waves of the ground mode. Excellent agreement is found between the results obtained by this method and frequency domain methods. This ...

1986-01-01

102

Interhemispheric Interactions between the Human Primary Somatosensory Cortices

The RNA packaging process for retroviruses involves a recognition event of the genome-length viral RNA by the viral Gag polyprotein precursor (PrGag), an important step in particle morphogenesis. The...Full Text Available

2003-09-01

103

Impact of kerogen heterogeneity on sorption of organic pollutants. 2. Sorption equilibria

In the somatosensory domain it is still unclear at which processing stage information reaches the opposite hemispheres. Due to dense transcallosal connections, the secondary somatosensory cortex (S2)...Full Text Available

104

Human intronic enhancers control distinct sub-domains of Gli3 expression during mouse CNS and limb development

Phenanthrene and naphthalene sorption isotherms were measured for three different series of kerogen materials using completely mixed batch reactors. Sorption isotherms were nonlinear for each sorbate-sorbent system, and the Freundlich isotherm equation fit the sorption data well. The Freundlich isotherm linearity parameter n ranged from 0.192 to 0.729 for phenanthrene and from 0.389 to 0.731 for naphthalene. The n values correlated linearly with rigidity and aromaticity of the kerogen matrix, but the single-point, organic carbon-normalized distribution coefficients varied dramatically among the tested sorbents. A dual-mode sorption equation consisting of a linear partitioning domain and a Langmuir adsorption domain adequately quantified the overall sorption equilibrium for each sorbent-sorbate system. Both models fit the data well, with r{sup 2} values of 0.965 to 0.996 for the Freundlich model and 0.963 to 0.997 for the dual-mode model for the ...

2009-08-15

105

Homology of SMP domains to the TULIP superfamily of lipid-binding proteins provides a structural basis for lipid exchange between ER and mitochondria

BackgroundThe zinc-finger transcription factor GLI3 is an important mediator of Sonic hedgehog signaling and crucial for patterning of many aspects of the vertebrate body plan. In...Full Text Available

106

Geometrical Symmetry in Symmetric Galerkin BEM.

Mitochondria must uptake some phospholipids from the endoplasmic reticulum (ER) for the biogenesis of their membranes. They convert one of these lipids, phosphatidylserine, to phosphatidylethanolamine,...Full Text Available

2010-08-15

107

Fourier-Domain Optical Coherence Tomography and Adaptive Optics Reveal Nerve Fiber Layer Loss and Photoreceptor Changes in a Patient With Optic Nerve Drusen

We consider a symmetric boundary integral formulation associated with a mixed boundary value problem defined on a domain Omega is an element of the set of real numbers(2) with piecewise smooth boundary Gamma. We assume that Omega is mapped onto itself by ...

2001-01-01

108

Expression in E. coli and characterization of the catalytic domain of Botrytis cinerea chitin synthase

BackgroundNew technology allows more precise definition of structural alterations of all retinal layers although it has not been used previously in cases of optic...Full Text Available

2008-06-01

109

Evolution of DMY, a newly emergent male sex-determination gene of medaka fish.

BackgroundChitin synthase 3a (CHS3a) from Botrytis cinerea (Bc) catalyses the multiple transfer of N-acetylglucosamine (GlcNAc) residues to the...Full Text Available

110

Electromagnetic fields, pacemakers and defibrillators; Champs electromagnetiques, cardiostimulateurs et defibrillateurs

The Japanese medaka fish Oryzias latipes has an XX/XY sex-determination system. The Y-linked sex-determination gene DMY is a duplicate of the autosomal gene DMRT1, which encodes a DM-domain-containing...Full Text Available

2004-04-01

111

Cyber as a 'Team Sport': Operationalizing a Whole-Of-Government Approach to Cyberspace Operations.

Presentation of electromagnetic sources constituted by various radio transmitters contributing to different radio communication services in the environment. Results of a measures campaign to assess the electromagnetic field in the close neighbourhood of various stations. Analysis by frequency domains. (author)

2004-07-01

112

Critical superparamagnetic/single-domain grain sizes in interacting magnetite particles: implications for magnetosome crystals

Cyberspace and its associated operations present both opportunities and challenges for military and United States Government decision-makers and planners. The Pentagon has formally recognized cyberspace as a domain of warfare. Cyberspace is man-made, dyna...

2011-01-01

113

Chimeric Antigen Receptor Therapy for B-cell Malignancies

Magnetotactic bacteria contain chains of magnetically interacting crystals (magnetosome crystals), which they use for navigation (magnetotaxis). To improve magnetotaxis efficiency, the magnetosome crystals...Full Text Available

2009-12-06

114

Cadherin Mechanics and Complexation: The Importance of Calcium Binding

We presented data showing that the CART-19 cells expressing the 4-1BB signaling domain can have unprecedented and massive in-vivo expansion, traffic to tumor sites, persist long term in vivo, and induce...Full Text Available

115

CLINICAL VALUE, NORMATIVE RETINAL SENSITIVITY VALUES, AND INTRASESSION REPEATABILITY USING A COMBINED SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY/SCANNING LASER OPHTHALMOSCOPE MICROPERIMETER

E-cadherins belong to a family of membrane-bound, cellular adhesion proteins. Their adhesive properties mainly involve the two N-terminal extracellular domains (EC1 and EC2). The junctions between these...Full Text Available

2005-12-01

116

Biochemical characterization of the molecular interaction between recombinant basic fibroblast growth factor and a recombinant soluble fibroblast growth factor receptor.

PurposeTo establish normative values for macular light sensitivity and to determine the intrasession fluctuation of perimetric responses using the OPKO/OTI microperimeter.Full Text Available

2011-02-01

117

AICD Overexpression in Neuro 2A Cells Regulates Expression of PTCH1 and TRPC5

The extracellular domain of human fibroblast growth factor receptor (XC-FGF-R) was expressed in Escherichia coli. The protein was purified to homogeneity and the interaction with basic fibroblast growth...Full Text Available

1993-09-15

118

A wide spectrum of clinical and brain MRI findings in patients with SLC19A3 mutations

Amyloid precursor protein (APP), implicated in Alzheimer's disease, is a transmembrane protein of undetermined function. APP is cleaved by gamma-secretase that releases the APP intracellular domain...Full Text Available

119

A multiarchitectonic approach for the definition of functionally distinct areas and domains in the monkey frontal lobe

BackgroundSLC19A3 (solute carrier family 19, member 3) is a thiamin transporter with 12 transmembrane domains. Homozygous or compound heterozygous mutations in SLC19A3 cause...Full Text Available

120

A Point Mutation in a Domain of Gamma Interferon Receptor 1 Provokes Severe Immunodeficiency

Over the last century, anatomical studies have shown that the cerebral cortex can be subdivided into structurally distinct regions, giving rise to a new branch of neuroanatomy: ‘architectonics’....Full Text Available

2007-08-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

121

A Cellular J-Domain Protein Modulates Polyprotein Processing and Cytopathogenicity of a Pestivirus

Gamma interferon (IFN-γ) and the cellular responses induced by it are essential for controlling mycobacterial infections. Most patients bearing an IFN-γ receptor ligand-binding chain...Full Text Available

2001-01-01

122

Transverse Resistive Wall Wakefunction with Inductive Bypass

Pestiviruses are positive-strand RNA viruses closely related to human hepatitis C virus. Gene expression of these viruses occurs via translation of a polyprotein, which is further processed by cellular...Full Text Available

2001-10-01

123

Quasilinear theory of the 2D Euler equation

Charged particle beams in circular accelerators couple with their surroundings through induced electromagnetic fields. This interaction can be described by so-called coupling impedances. In the frequency domain the impedance in connection with the bunch spectrum allows for stability analysis and estimates. However, for simulation codes one usually needs the wakefunction, the equivalent of the impedance in time domain. Recently the transverse impedance of a cylindrical pipe with arbitrary surface impedance was given by L. Vos. An expression for the wakefunction of this transverse resistive wall impedance with inductive bypass is derived here.

2003-01-01

124

Prediction of motions and tension in mooring lines on slack-moored floating oceanic architectural building in coastal zones

Motivated by the numerical investigations of Laval, Dubrulle & Nazarenko (1999), we develop a quasilinear theory of the 2D Euler equation and derive an integro-differential equation for the evolution of the coarse-grained vorticity. This equation respects all the invariance properties of the Euler equation and conserves angular momentum in a circular domain and linear impulse in a channel (as well as in an infinite domain). The explicit energy is not rigorously conserved as it is partly transfered into fine-grained fluctuations but the total energy is conserved. We prove a H-theorem for the Fermi-Dirac entropy and make the connection with statistical theories of 2D turbulence.

2000-01-01

125

Pre-waste-emplacement ground-water travel time sensitivity and uncertainty analyses for Yucca Mountain, Nevada; Yucca Mountain Site Characterization Project

The present paper is concerned with the prediction method for the motions and tensions of mooring lines on slack-moored floating oceanic architectural building in coastal zone. The motions and the tensions of mooring lines were estimated by the time domain numerical simulation in the present method. The present method includes the nonlinearity of mooring system, slow varying wave drift force. The authors performed a time domain numerical simulation for motions and the tensions of mooring lines on floating barge in two component waves. Also, the results obtained by numerical simulation were compared with the experimental results. The validity of the present method was confirmed.

1995-12-31

126

Overview of bunch length measurements.

Yucca Mountain, Nevada is a potential site for a high-level radioactive-waste repository. Uncertainty and sensitivity analyses were performed to estimate critical factors in the performance of the site with respect to a criterion in terms of pre-waste-emplacement ground-water travel time. The degree of failure in the analytical model to meet the criterion is sensitive to the estimate of fracture porosity in the upper welded unit of the problem domain. Fracture porosity is derived from a number of more fundamental measurements including fracture frequency, fracture orientation, and the moisture-retention characteristic inferred for the fracture domain.

1993-01-01

127

Nonlinear time-domain modeling of balanced-armature receivers

An overview of particle and photon beam bunch length measurements is presented in the context of free-electron laser (FEL) challenges. Particle-beam peak current is a critical factor in obtaining adequate FEL gain for both oscillators and self-amplified spontaneous emission (SASE) devices. Since measurement of charge is a standard measurement, the bunch length becomes the key issue for ultrashort bunches. Both time-domain and frequency-domain techniques are presented in the context of using electromagnetic radiation over eight orders of magnitude in wavelength. In addition, the measurement of microbunching in a micropulse is addressed.

1999-02-19

128

DEFF Research Database (Denmark)

Nonlinear distortion added by the loudspeaker in a hearing aid lowers the signal-to-noise ratio and may degrade the hearing aid user's ability to understand speech. The balancedarmature- type loudspeakers, predominantly used in hearing aids, are inherently nonlinear devices, as any displacement of the loudspeaker diaphragm inevitably changes the magnetic and electrical characteristics of the loudspeaker. A numerical time-domain model capable of describing these nonlinearities is presented. By simulation it is demonstrated how the output distortion could potentially be reduced significantly through careful design of the mechanical properties of the armature.

2011-01-01

129

Integration of an expert teaching assistant with distance learning software

Frequency response characteristics of the fuzzy polar power system stabilizer

The Remote Teaching Assistant (RTA) software currently under development at UC Davis allows students and Teaching Assistants (TA`s) to interact through multimedia communication via the Internet. To resolve the problem of TA unavailability and limited knowledge, an Expert Teaching Assistant (ETA) module is being developed. When TA`s are not on-line, students in need of help consult ETA. The focus of this research is the development and integration of ETA with RTA, the establishment of an architecture suitable for use with education (the domain) in any sub-domain (course), and the creation of a mechanism usable by non-technical personnel to maintain knowledge bases.

1996-12-31

130

Domain wall pining in a jointed ferromagnetic nano-wire

The fuzzy polar power system stabilizer (FPPSS) which has been recently developed is analyzed using frequency domain methods. the frequency domain approach allows the PSS designer to compare the new FPPSS with more conventional controllers. The significance of the three FPPSS design parameters are readily seen from the frequency response data, and their relationship to the conventional lead-lag design approach can be evaluated. Furthermore, the frequency response data for the FPPSS allows an alternate design approach for this stabilizer, and can be used to develop information concerning the small signal stability of the resulting system.

1995-06-01

131

Application of the IPEBS method to dynamic contingency analysis

The magnetoresistance in an FeNi submicron-structure comprising two wires of 80 and 200 nm in width connected in series was measured at 77 K. When the external magnetic field was applied parallel to the wire axis, two switching fields corresponding to the distinct coercive force of the two wires were observed. When the external magnetic field was applied at an angle of {theta}>30 deg. to the wire axis one switching field was observed, indicating simultaneous magnetization reversal in both wires. This indicates that the domain-wall trapping around the joint can be controlled systematically in terms of the direction of the external magnetic field.

2004-05-01

132

A review of the probabilistic aspects of localized corrosion

Dynamic contingency analysis is certainly a demanding task in the context of dynamic performance evaluation. This paper presents the results of a test for checking the contingency screening capability of the IPEBS method. A brazilian 1100-bus, 112-gen system was used in the test; the ranking of the contingencies based on critical clearing times obtained with IPEBS, was compared with the ranking derived from detailed time-domain simulation. The results of this comparison encourages us to recommended the use of the method in industry applications, in a complementary basis to the current method of time domain simulation. (author) 5 refs., 1 fig., 2 tabs.

1994-12-31

133

Modification of surface texture by grinding and polishing lead zirconate titanate ceramics

Localized corrosion has a stochastic character by nature. This character leads to an observed random behavior: fluctuations of the free potential, fluctuations of the current when a constant potential is maintained. This random signal, which is similar to an electric noise, can be analyzed either in the time domain by counting the events or in the frequency domain by measuring the power spectral density of the electrochemical noise. The experimental techniques developed for investigating the localized corrosion on the probabilistic point of view, i.e., statistical counting and power spectral density measurements, are discussed. Then the experimental results reported in the literature are reviewed in order to see what kind of parameters are accessible and how they can be related to the localized corrosion processes.

1990-04-01

134

Modification of surface texture by grinding and polishing lead zirconate titanate ceramics

This paper reports that grinding and polishing affected the orientation of 90[degrees] domains at the surface of lead zirconate titanate (PZT) ceramics. This was quantified by using changes in the intensity ratio of the (002) and (200) X-ray reflections. Grinding unpoled PZT with 600-grit SiC paper gave X-ray intensity ratios similar to those of poled material. This implies that 90[degrees] domain realignments had occurred in the near surface region probed by the X-rays. Grinding poled samples with 600-grit SiC further increased the X-ray intensity ratio beyond that caused by poling, indicating that additional surface reorientation of 90[degrees] domains had occurred. The effects of diamond polishing depended on the size of the diamond particles. The use of 6-[mu]m diamond had no effect on the (002)/(200) intensity ratio of either poled or unpoled samples, while polishing with 15- or 45-[mu]m diamond significantly enhanced ...

1992-08-01

135

Structural Insights into the Interaction of the Evolutionarily Conserved ZPR1 Domain Tandem with Eukaryotic EF1A, Receptors, and SMN Complexes

This paper reports that grinding and polishing affected the orientation of 90 degrees domains at the surface of lead zirconate titanate (PZT) ceramics. This was quantified by using changes in the intensity ratio of the (002) and (200) X-ray reflections. Grinding unpoled PZT with 600-grit SiC paper gave X-ray intensity ratios similar to those of poled material. This implies that 90 degrees domain realignments had occurred in the near surface region probed by the X-rays. Grinding poled samples with 600-grit SiC further increased the X-ray intensity ratio beyond that caused by poling, indicating that additional surface reorientation of 90 degrees domains had occurred. The effects of diamond polishing depended on the size of the diamond particles. The use of 6-#mu#m diamond had no effect on the (002)/(200) intensity ratio of either poled or unpoled samples, while polishing with 15- or 45-#mu#m diamond significantly enhanced the ...

1992-01-01

136

Spin-resolved magnetic studies of focused ion beam etched nano-sized magnetic structures

Eukaryotic genomes encode a zinc finger protein (ZPR1) with tandem ZPR1 domains. In response to growth stimuli, ZPR1 assembles into complexes with eukaryotic translation elongation factor 1A (eEF1A) and the survival motor neurons protein. To gain insight into the structural mechanisms underlying the essential function of ZPR1 in diverse organisms, we determined the crystal structure of a ZPR1 domain tandem and characterized the interaction with eEF1A. The ZPR1 domain consists of an elongation initiation factor 2-like zinc finger and a double-stranded {beta} helix with a helical hairpin insertion. ZPR1 binds preferentially to GDP-bound eEF1A but does not directly influence the kinetics of nucleotide exchange or GTP hydrolysis. However, ZPR1 efficiently displaces the exchange factor eEF1B from preformed nucleotide-free complexes, suggesting that it may function as a negative regulator of eEF1A activation. Structure-based ...

2007-01-01

137

Temporal measures and controls in ultrafast laser domain; Mesures et controles temporels dans le domaine des lasers ultrabrefs

Scanning ion microscopy with polarization analysis (SIMPA) is used to study the spin-resolved surface magnetic structure of nano-sized magnetic systems. SIMPA is utilized for in situ topographic and spin-resolved magnetic domain imaging as well as for focused ion beam (FIB) etching of desired structures in magnetic or non-magnetic systems. Ultra-thin Co films are deposited on surfaces of Si(1 0 0) substrates, and ultra-thin, tri-layered, bct Fe(1 0 0)/Mn/bct Fe(1 0 0) wedged magnetic structures are deposited on fcc Pd(1 0 0) substrates. SIMPA experiments clearly show that ion-induced electrons emitted from magnetic surfaces exhibit non-zero electron spin polarization (ESP), whereas electrons emitted from non-magnetic surfaces such as Si and Pd exhibit zero ESP, which can be used to calibrate sputtering rates in situ. We report on new, spin-resolved magnetic microstructures, such as magnetic 'C' states and magnetic vortices, found at surfaces of FIB patterned ...

2005-04-01

138

Role of Data Mining in E-Payment systems

This work presents the development of a streak camera 'jitter free' sweep unit synchronized on a femtosecond laser. This application of high voltage photoconductive switches ('High voltage Auston switch') yields subpicosecond resolution for accumulated images on streak camera on a few hundreds micro joule femtosecond laser. Two others applications of these photoconductive switches are studied: - ultrafast optical commutation by a Pockels cell directly driven by a photoconductive switch (rising edge < 100 ps and jitter < 2 ps), - laser pulse energy self-stabilization experimentally proving that driving a Pockels cell by a photoconductive switch can increase the stability of the laser pulse energy from 7 % to 0.7 % rms. Additionally, the application of the acoustic-optical programmable dispersive filter (Dazzler) to the self referenced spectral phase measurement is presented. As these measurements require a linear filter combined with a ...

2004-12-15

139

Mapping cis-Regulatory Domains in the Human Genome UsingMulti-Species Conservation of Synteny

Data Mining deals extracting hidden knowledge, unexpected pattern and new rules from large database. Various customized data mining tools have been developed for domain specific applications such as Biomedicine, DNA analysis and telecommunication. Trends in data mining include further efforts towards the exploration of new application areas and methods for handling complex data types, algorithm scalability, constraint based data mining and visualization methods. In this paper we will present domain specific Secure Multiparty computation technique and applications. Data mining has matured as a field of basic and applied research in computer science in general. In this paper, we survey some of the recent approaches and architectures where data mining has been applied in the fields of e-payment systems. In this paper we limit our discussion to data mining in the context of e-payment systems. We also mention a few directions for further work in ...

2010-01-01

140

Ising model for phase separation in alloys with anisotropic elastic interaction. 2: A computer experiment

Our inability to associate distant regulatory elements with the genes that they regulate has largely precluded their examination for sequence alterations contributing to human disease. One major obstacle is the large genomic space surrounding targeted genes in which such elements could potentially reside. In order to delineate gene regulatory boundaries we used whole-genome human-mouse-chicken (HMC) and human-mouse-frog (HMF) multiple alignments to compile conserved blocks of synteny (CBS), under the hypothesis that these blocks have been kept intact throughout evolution at least in part by the requirement of regulatory elements to stay linked to the genes that they regulate. A total of 2,116 and 1,942 CBS>200 kb were assembled for HMC and HMF respectively, encompassing 1.53 and 0.86 Gb of human sequence. To support the existence of complex long-range regulatory domains within these CBS we analyzed the prevalence and distribution of chromosomal aberrations ...

2005-06-13

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

141

Imaging magnetic domain structure in sub-500 nm thin film elements

When a metallic alloy is quenched into a miscibility gap, a mixture of two phases develops, whose domain structure then coarsens because of the interfacial energy between the two phases. This spatial arrangement of the domains and the rate at which they evolve may be strongly influenced by elastic interactions. In a recent paper, the authors described a method for simulating the effect of anisotropic elastic interactions in a two-dimensional Ising model of a cubic alloy, using Kawasaki dynamics with the elastic interactions represented by a long-range two-body interaction potential. Here they present the results of such simulations at various temperatures, alloy compositions and misfits (by misfit they mean the difference in size between the two kinds of atom), exhibiting snapshots both of the microscopic configurations (corresponding to experimental measurements using transmission electron microscopy) and of their squared Fourier transforms ...

1996-08-01

142

Electric field measurement on time domain generated by corona on insulators on distribution systems

Magnetic imaging in the transmission electron microscope (TEM) has been used to examine submicron elements with the aim of discovering down to what element size complex domain patterns can form. The elements were squares, circles, triangles, and pentagons in the size range 100{endash}500 nm and were made from 36 nm Co films or 8 nm Ni{sub 80}Fe{sub 20} (NiFe) with in-plane magnetization. The magnetic domain structures in these elements were imaged at high resolution using the differential phase contrast imaging mode in a TEM. Nonuniform magnetization structures were seen in the images. Vortices were present at remanence in all shapes of 36-nm-thick Co elements down to 100 nm size and in circular NiFe elements down to 116 nm diameter. Triangular NiFe elements did not have a vortex state at remanence, instead the magnetization curved round within the element but did not achieve complete flux closure. In simulations of square and circular NiFe ...

2001-06-01

143

Determination of Inter-Phase Line Tension in Langmuir Films

Radio interference and TV interference are being a problem in urban and rural areas. This interference is generated by high voltage transmission lines as well as distribution lines. The radio noise can be produced by polluted or damaged insulators, and by metal parts of the distribution lines. The corona effect on the surface of the dielectric material produces high frequency electromagnetic fields during the ionization and during the recombination period. Fields of different intensity are produced by positive voltage and negative voltage. The insulator flashover (leaking current) also produces electromagnetic fields. A new technique to measure these fields was developed. This technique measures the radiated fields on time domain and on frequency domain. This permits us to characterize the radiated field and thus identify the type of the source. Several measurements were done varying the type of the RF generator, i.e., new insulator and broken ...

1996-12-31

144

Computational Models of Certain Hyperspaces of Quasi-metric Spaces

A Langmuir film is a molecularly thin film on the surface of a fluid; we study the evolution of a Langmuir film with two co-existing fluid phases driven by an inter-phase line tension and damped by the viscous drag of the underlying subfluid. Experimentally, we study an 8CB Langmuir film via digitally-imaged Brewster Angle Microscopy (BAM) in a four-roll mill setup which applies a transient strain and images the response. When a compact domain is stretched by the imposed strain, it first assumes a bola shape with two tear-drop shaped reservoirs connected by a thin tether which then slowly relaxes to a circular domain which minimizes the interfacial energy of the system. We process the digital images of the experiment to extract the domain shapes. We then use one of these shapes as an initial condition for the numerical solution of a boundary-integral model of the underlying hydrodynamics and compare the subsequent images of ...

2007-01-01

145

Changes in dielectric properties of Pb(In{sub 1/2}Nb{sub 1/2})O{sub 3}-PbTiO{sub 3} ceramics under compressive stress applied parallel and perpendicular to an electric field

In this paper, for a given sequentially Yoneda-complete T_1 quasi-metric space (X,d), the domain theoretic models of the hyperspace K_0(X) of nonempty compact subsets of (X,d) are studied. To this end, the $\\omega$-Plotkin domain of the space of formal balls BX, denoted by CBX is considered. This domain is given as the chain completion of the set of all finite subsets of BX with respect to the Egli-Milner relation. Further, a map $\\phi:K_0(X)\\rightarrow CBX$ is established and proved that it is an embedding whenever K_0(X) is equipped with the Vietoris topology and respectively CBX with the Scott topology. Moreover, if any compact subset of (X,d) is d^{-1}-precompact, \\phi is an embedding with respect to the topology of Hausdorff quasi-metric H_d on K_0(X). Therefore, it is concluded that (CBX,\\sqsubseteq,\\phi) is an $\\omega$-computational model for the hyperspace K_0(X) endowed with the Vietoris and respectively the ...

2011-01-01

146

Wnt/b-catenin signal pathway stabilizes APP intracellular domain (AICD) and promotes its transcriptional activity

The influences of compressive stress on the dielectric properties of (1 - x)Pb(In{sub 1/2}Nb{sub 1/2})O{sub 3}-xPbTiO{sub 3} (x = 0.1-0.5) ceramics was investigated in this study. The dielectric properties were measured under compressive stress applied parallel and perpendicular to electric field. The results clearly showed that the superimposed compression stress had pronounced effects on the dielectric properties of PIN-PT ceramics. In general, with increasing compressive stress the dielectric constant of the ceramics increased and decreased when the stress was applied parallel and perpendicular, respectively, to the electric field direction. The dielectric loss tangent, however, decreased in both stress cases. The observations were mainly interpreted in terms of competing influences of the domain switching through non-180 deg. domain walls, clamping of domain walls, de-ageing and the stress-induced decrease in the ...

2008-04-21

147

British Library Electronic Table of Contents (United Kingdom)

Amyloid precursor protein (APP), a key protein in pathogenesis of Alzheimer's disease (AD), is a type I transmembrane protein which can be cleaved by b- and g-secretase to release the amyloidogenic b-amyloid peptides (Ab) and the APP intracellular domain (AICD). While Ab has been widely believed to initiate pathogenic cascades culminating AD, the physiological functions and regulations of AICD remain elusive. In present study, endogenous AICD was demonstrated to be increased by canonical Wnt signal. Instead of due to g-secretase activity, enhanced AICD expression was found due to the increased protein stability by Wnt/b-catenin. b-Catenin was demonstrated to be an associating partner of AICD, capable of promoting AICD mediated transcriptional activity. Investigation by AICD mutants proved ...

2011-01-01

148

Verification of knowledge bases based on containment checking

Time-domain analysis of FPSO-tanker responses in tandem offloading operation

Building complex knowledge based applications requires encoding large amounts of domain knowledge. After acquiring knowledge from domain experts, much of the effort in building a knowledge base goes into verifying that the knowledge is encoded correctly. We consider the problem of verifying hybrid knowledge bases that contain both Horn rules and a terminology in a description logic. Our approach to the verification problem is based on showing a close relationship to the problem of query containment. Our first contribution, based on this relationship, is presenting a thorough analysis of the decidability and complexity of the verification problem, for knowledge bases containing recursive rules and the interpreted predicates =, {le}, < and {ne}. Second, we show that important new classes of constraints on correct inputs and outputs can be expressed in a hybrid setting, in which a description logic class hierarchy is also considered, and we ...

1996-12-31

149

British Library Electronic Table of Contents (United Kingdom)

Problems experienced during Floating Production, Storage and Offloading (FPSO) tandem offloading operations were investigated. The aim of this research was to improve the reliability of such systems, and it needed a means to assess them. Time-domain simulation and analysis of offloading systems was performed using the multi-body mooring software ARIANE 7.0. Hydrodynamic interaction between the vessels was considered. The responses of the offloading system in different loading cases, different parameters of offloading hawsers and the effects of challenging environmental conditions were calculated. There was a focus on the problems of relative motion between the two bodies and its effects on the intensity of hawser forces. Minimum relative distance, maximum relative headings and maximum tens...

2010-01-01

150

The Notch ligand Delta-like 1 integrates inputs from TGFbeta/Activin and Wnt pathways

British Library Electronic Table of Contents (United Kingdom)

Unlike the well-characterized nuclear function of the Notch intracellular domain, it has been difficult to identify a nuclear role for the ligands of Notch. Here we provide evidence for the nuclear function of the Notch ligand Delta-like 1 in colon cancer (CC) cells exposed to butyrate. We demonstrate that the intracellular domain of Delta-like 1 (Dll1icd) augments the activity of Wnt signaling-dependent reporters and that of the promoter of the connective tissue growth factor (CTGF) gene. Data suggest that Dll1icd upregulates CTGF promoter activity through both direct and indirect mechanisms. The direct mechanism is supported by co-immunoprecipitation of endogenous Smad2/3 proteins and Dll1 and by chromatin immunoprecipitation analyses that revealed the occupancy of Dll1icd on CTGF promot...

2011-01-01

151

Terahertz time-domain spectroscopy of atmospheric water vapor from 0.4 to 2.7 THz.

T cell receptor beta chain from sea bream (Sparus aurata): Molecular cloning, expression and modelling of the complexes with MHC class I

We conducted broadband absorption measurements of atmospheric water vapor in the ground state, X {sup 1}A{sub 1} (000), from 0.4 to 2.7 THz with a pressure broadening-limited resolution of 6.2 GHz using pulsed, terahertz time-domain spectroscopy (THz-TDS). We measured a total of seventy-two absorption lines and forty-nine lines were identified as H{sub 2}{sup 16}O resonances. All the H{sub 2}{sup 16}O lines identified were confirmed by comparing their center frequencies to experimental values available in the literature.

2005-10-01

152

British Library Electronic Table of Contents (United Kingdom)

The T cell receptor is a fundamental mediator of the adaptive immune responses, since TR ab on T cells recognize foreign structures (peptides derived from processed antigens) bound to the major histocompatibility complex (MHC) on APC cells. In the present study, we report the cloning of six TRB chains cDNA sequences from gilthead sea bream (Sparus aurata), a fish of high economical impact in South Mediterranean aquaculture. The V-BETA domains have the canonical features of known teleost and mammalian TR V-BETA domains and have been divided in four different subgroups. A multiple alignment of the six sea bream TRB chains with other known TRB sequences was assembled and showed the conservation of the four cysteine residues involved in disulphide bonds and of some amino acids with an importan...

2008-01-01

153

Symbolic image understanding. Final report Sep 87-Aug 90

Pyro-chemistry within the FP7 ACSEPT Project-Program and Objective

This report summarizes the work done at the University of Massachusetts in the area of Image Understanding of static scene domains. The goal of this research project was to demonstrate a practical knowledge-based approach to computer vision that utilized multiple levels of parallel processing. Some problems dealt with included extracting lines, grouping together regions and lines from the same surface, computing pose from geometry, and matching corresponding features in different views. Special attention was also given to the extraction of curved lines and curved surfaces. The static scene domains consisted of both ROAD and HOUSE scenes, each containing approximately fourteen (14) different objects per scene.

1991-11-01

154

Photoreceptor Inner and Outer Segment Defects in Myopic Foveoschisis

Actinide recycling by partitioning and transmutation is considered as one of the most promising strategies to reduce the inventory of radioactive waste, thus contributing to make nuclear energy sustainable. To make advances beyond the current state of the art in pyrochemical separations processes, the Domain 2 (DM2) of ACSEPT has been built on considering a process approach based on system studied. Four work packages that represent the main steps of a process block diagram have been identified: head-end steps, core process development, and salt treatment for recycling and waste conditioning. The results obtained in this domain will be integrated in DM 3 (Process) in order to orientate the R and D studies of DM2 and to propose and validate flowsheets at the end of the project. The state of the art on pyrochemical separation within the European Community and the working program of ACSEPT in pyrometallurgy are presented in this work. (authors)

2008-07-01

155

British Library Electronic Table of Contents (United Kingdom)

PurposeTo evaluate pathologic features of the photoreceptors in myopic foveoschisis with the Fourier-domain optical coherence tomography (FD-OCT).DesignObservational case series.MethodsSeventeen eyes of 15 patients with myopic foveoschisis (foveal detachment type, six eyes; foveoschisis type, 11 eyes) were included. We observed the photoreceptor inner and outer segments (IS/OS) and evaluated the morphologic status using FD-OCT. Fundus photographs and time-domain OCT (TD-OCT) images also were obtained.ResultsIS/OS defects, which are uncommon in retinal detachments in eyes with myopia, were seen clearly in five eyes (three eyes [50%] with the foveal detachment type; two eyes [18%] with the foveal schisis type). Fundus photographs showed myopic chorioretinal atrophy in eight study eyes (47%),...

2008-01-01

156

Ordered magnetic nanohole and antidot arrays prepared through replication from anodic alumina templates

Ordered magnetic nanohole and antidot arrays prepared through replication from anodic alumina templates

Highly ordered arrays of Ni nanoholes and Fe{sub 20}Ni{sub 80} antidots have been prepared, respectively, by replica/antireplica processing and sputtering techniques using nanoporous alumina membranes as templates. Geometrical characteristics as nanohole/antidot diameter, interpore distance and the overall hexagonal symmetry of arrays are controlled through the original templates. Experimental data on their hysteresis and magnetic domain structure have been taken by vibrating sample magnetometry and magnetic force microscopy, respectively. An analysis of the magnetization process, resulting magnetic anisotropy and magnetic domain structure is summarized considering the influence of those geometry aspects. In particular, the hexagonal symmetry and the density of nanohole/antidots determine the overall magnetic behavior, which is of interest in future high-density magnetic storage systems.

2008-07-15

157

Multi-domain, higher order level set scheme for 3D image segmentation on the GPU

Highly ordered arrays of Ni nanoholes and Fe20Ni80 antidots have been prepared, respectively, by replica/antireplica processing and sputtering techniques using nanoporous alumina membranes as templates. Geometrical characteristics as nanohole/antidot diameter, interpore distance and the overall hexagonal symmetry of arrays are controlled through the original templates. Experimental data on their hysteresis and magnetic domain structure have been taken by vibrating sample magnetometry and magnetic force microscopy, respectively. An analysis of the magnetization process, resulting magnetic anisotropy and magnetic domain structure is summarized considering the influence of those geometry aspects. In particular, the hexagonal symmetry and the density of nanohole/antidots determine the overall magnetic behavior, which is of interest in future high-density magnetic storage systems.

2008-07-01

158

DEFF Research Database (Denmark)

Level set method based segmentation provides an efficient tool for topological and geometrical shape handling. Conventional level set surfaces are only $C^0$ continuous since the level set evolution involves linear interpolation to compute derivatives. Bajaj et al. present a higher order method to evaluate level set surfaces that are $C^2$ continuous, but are slow due to high computational burden. In this paper, we provide a higher order GPU based solver for fast and efficient segmentation of large volumetric images. We also extend the higher order method to multi-domain segmentation. Our streaming solver is efficient in memory usage.

2010-01-01

159

Modulation of proton NMR free induction decay by spin diffusion

Lorentz transmission electron microscopy investigation of magnetically patterned Co/Pt multilayers

The effects of spin diffusion on the free induction decay (FID) of protons associated with the noncrystalline domains of two polymers, polyethylene and blended Nylon 66 (ZYTEL-408), have been examined using Goldman--Shen NMR pulse sequence ((1/2)..pi..x-t/sub 0/-(1/2)..pi..x-bar-tau-(1/2)..pi..x-t). At tau< or approx. =100 ..mu..s, the FID is drastically distorted from the exponential form while at longer tau(tau> or approx. =500 ..mu..s) an exponential FID is observed; but its transverse spin relaxation rate is smaller than that of the FID obtained after a single (1/2)..pi..x pulse and approaches this value at the limit of large tau. These findings are interpreted in terms of the theory of rapid spin diffusion. The spatial variation in the spin relaxation rate within the noncrystalline domain is inferred.

1982-02-01

160

Junction conditions in General Relativity with spin sources

The switching behavior of magnetic patterns prepared by ion irradiation was investigated. Co/Pt multilayers with perpendicular anisotropy and large out-of-plane coercivities 5-6 kOe were grown on electron transparent SiN windows. Regularly spaced 1 micron sized regions, were magnetically pattered via ion beam irradiation through a stencil mask. Lorentz TEM was used to observe in-situ magnetization reversal processes of irradiated regions under well-defined applied magnetic fields. When the in-plane field was increased, domain wall motion was observed, resulting in the alignment of the patterns with the direction of the applied field. The switching mechanism of the in-plane patterns was by domain wall motion.

2000-08-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

161

J/Psi dissociation in parity-odd bubbles

The junction conditions for General Relativity in the presence of domain walls with intrinsic spin are derived in three and higher dimensions. A stress tensor and a spin current can be defined just by requiring the existence of a well defined volume element instead of an induced metric, so as to allow for generic torsion sources. In general, when the torsion is localized on the domain wall, it is necessary to relax the continuity of the tangential components of the vielbein. In fact it is found that the spin current is proportional to the jump in the vielbein and the stress-energy tensor is proportional to the jump in the spin connection. The consistency of the junction conditions implies a constraint between the direction of flow of energy and the orientation of the spin. As an application, we derive the circularly symmetric solutions for both the rotating string with tension and the spinning dust string in three dimensions. The rotating ...

2006-01-01

162

Influence of shape on ordering of granular systems in two dimensions

We calculate the quarkonium dissociation rate in the P and CP-odd domains (bubbles) that were possibly created in heavy-ion collisions. In the presence of the magnetic field produced by the valence quarks of colliding ions, parity-odd domains generate electric field. Quarkonium dissociation is the result of quantum tunneling of quark or antiquark through the potential barrier in this electric field. The strength of the electric field in the quarkonium comoving frame depends on the quarkonium velocity with respect to the background magnetic field. We investigate momentum, electric field strength and azimuthal dependence of the dissociation rate. Azimuthal distribution of quarkonia surviving in the electromagnetic field is strongly anisotropic; the form of anisotropy depends on the relation between the electric and magnetic fields and quarkonium momentum. These features can be used to explore the properties of the electromagnetic field created in ...

2011-01-01

163

Improving Term Extraction Using Particle Swarm Optimization Techniques

We investigate ordering properties of two-dimensional granular materials using several shapes created by welding ball bearings together. Ordered domains form much more easily in two than in three dimensions, even when configurations lack long-range order. The onset of ordered domains occurs near a packing density of 0.8, a phenomenon observed previously for disks. One of our shapes, the trapezoid, has packings that remain disordered and near the transition density even after annealing by shaking. Although random packings are unstable for disks and many other shapes in two dimensions, trapezoid packings provide an approach to studying two-dimensional randomness. We also find that the rotational symmetry of a shape is an excellent predictor of how easily it orders, and a potential guide to identifying two-dimensional shapes that remain random after annealing.

2001-06-01

164

Hydrophobic labelling of membrane-embedded proteins with lipophilic reagents

Term extraction is one of the layers in the ontology development process which has the task to extract all the terms contained in the input document automatically. The purpose of this process is to generate list of terms that are relevant to the domain of the input document. In the literature there are many approaches, techniques and algorithms used for term extraction. In this paper we propose a new approach using particle swarm optimization techniques in order to improve the accuracy of term extraction results. We choose five features to represent the term score. The approach has been applied to the domain of religious document. We compare our term extraction method precision with TFIDF, Weirdness, GlossaryExtraction and TermExtractor. The experimental results show that our propose approach achieve better precision than those four algorithm.

2010-01-01

165

High-Resolution Optical Coherence Tomography Findings in Solar Maculopathy and the Differential Diagnosis of Outer Retinal Holes

Hydrophobic labelling is frequently used in the study of membrane-inserted domains of intrinsic proteins. However, the published procedures, fail to incorporate sufficient radioactivity into membrane immunoglobulins of B lymhocytes to permit investigation of their subunit structures and associations with other proteins. In order to increase the specific radioactivity of ["1"2"5I]iodonaphtylazide ["1"2"5I]INA), an improved method for the synthesis of the reagent was developed. In addition, the optimal conditions for labelling B lymhpocytes with ["1"2"5I]INA and commercially available reagent 3-(trifluoromethyl)-3-(trifluoromethyl)-3-(3'-["1"2"5Iliodophenyl)diazirine (["1"2"5I]TID were isolated and analysed in detail by SDS-PAGE. The usefulness of the two reagents for the investigation of lipid-embedded domains of membrane proteins is discussed. (author). 28 refs.; 4 figs.

166

British Library Electronic Table of Contents (United Kingdom)

PurposeTo characterize the morphology of outer retinal holes caused by solar maculopathy, using spectral-domain optical coherence tomography (SD-OCT). DesignThis study is an observational case series. MethodsThe SD-OCT findings of 3 patients (6 eyes) with chronic solar maculopathy are presented. ResultsSD-OCT demonstrates a characteristic appearance of partial-thickness hole(s) in the outer retina at the fovea. In 3 of 6 eyes, there is 1 hole directly beneath the umbo. In the remaining 3 eyes, there are multifocal holes spread across the fovea. Holes in more restricted layers, as had been previously reported with time-domain OCT, were not seen. In addition, advanced visualization of SD-OCT data demonstrates a hyperreflective ring around the outer retinal hole. ConclusionsSD-OCT can be used...

2011-01-01

167

Gear crack level identification based on weighted K nearest neighbor classification algorithm

British Library Electronic Table of Contents (United Kingdom)

A crack fault is one of the damage modes most frequently occurring in gears. Identifying different crack levels, especially for early cracks is a challenge in gear fault diagnosis. This paper aims to propose a method to classify the different levels of gear cracks automatically and reliably. In this method, feature parameters in time domain, specially designed for gear damage detection and in frequency domain are extracted to characterize the gear conditions. A two-stage feature selection and weighting technique (TFSWT) via Euclidean distance evaluation technique (EDET) is presented and adopted to select sensitive features and remove fault-unrelated features. A weighted K nearest neighbor (WKNN) classification algorithm is utilized to identify the gear crack levels. The gear crack experime...

2009-01-01

168

Electron accelerators, present and future applications

Effects of molecular mobility on high resolution solid state NMR spectra: model systems

The development and occurrence of new electron accelerators and applications are according to the human society development law, as a whole. The period of economic standstill is generating an intense creative activity in the domain of science and engineering which also resulting in great achievements in the field of electron accelerators. This paper presents the basic principle of the electron beam applications and the accelerators required characteristics for their present and potential applications in the domains: radiation sources, diagnostics, radiation processing, energetics, environment, defense and basic sciences. All these are correlated to the new generation of accelerators which, for the acceleration process, may employ electromagnetic fields generated by standard sources, atomic lasers, free electron lasers, Cerenkov effect, Smith - Purcell effect, electron beams, plasma, excited atoms into a crystal or other sources. Some more ...

169

Dielectric abnormities in BaTi_0_._9(Ni_1_/_2W_1_/_2)_0_._1O_3 giant dielectric constant ceramics

It is the intention of this paper to point to some of the problems due to molecular motion and to suggest a few solutions to those problems. A few examples will be presented of model systems which demonstrate the effects of motion on the NMR spectroscopy and a very qualitative example of severe spectral distortion in fulvic acids will be shown. In the following discussions we will use concepts derived from the oft repeated thermodynamic picture shown in figure 1. When dealing with a homogeneous, pure compound this picture is sufficient but in a heterogeneous mixture, it is likely that there will be different compounds and different domains all with slightly different versions of figure 1 with poor thermodynamic contact between them. Thus optimal conditions for cross polarization in one domain may be totally inappropriate for another. 59 refs., 10 figs.

1986-01-01

170

Design and development of an innovative hybrid powder based on a computer simulation and its application to foundation makeup products

BaTi_0_._9(Ni_1_/_2W_1_/_2)_0_._1O_3 ceramics were fabricated and their dielectric properties were investigated. With the sintering temperature increasing from 1250 to 1280 deg. C, the grain size abruptly increases from 1-2 to 20-40 #mu#m, accompanying significant changes in dielectric response. The samples with larger grains exhibit giant dielectric constant characteristics, which are considered to be mainly attributed to the domain boundary effect. The activation energies of the dielectric relaxation E_r_e_l_a_x=0.325 eV reveal the existence of microdomains in larger grains. The ac conductivity results also give the evidence of the domain boundary effect in the present ceramics.

2007-07-30

171

British Library Electronic Table of Contents (United Kingdom)

An innovative hybrid powder prepared using computer simulation allowed development of a new foundation having a fine, smooth texture that has never been achieved before. The optical structure/design of the powder was based on the results of measurements and analyses conducted on the optical characteristics of a baby's delicate skin, which is the envy of many women. To obtain the optimal optical characteristics, the finite differential time domain (FDTD) method for solving Maxwell's differential equation by difference and time domain was applied to the computer simulation method. For synthesis of the hybrid powder based on the optical model, a proprietary shape regulation coating technology was used in which flaky substrates were coated with microspherical forms of barium sulfate crystals. ...

2008-01-01

172

Basement of the South China Sea Area: Tracing the Tethyan Realm

British Library Electronic Table of Contents (United Kingdom)

Abstract: The basement of the South China Sea (SCS) and adjacent areas can be divided into six divisions (regions) - Paleozoic Erathem graben-faulted basement division in Beibu Gulf, Paleozoic Erathem strike-slip pull-apart in Yinggehai waters, Paleozoic Erathem faulted-depression in eastern Hainan, Paleozoic Erathem rifted in northern Xisha (Paracel), Paleozoic Erathem strike-slip extending in southern Xisha, and Paleozoic-Mesozoic Erathem extending in Nansha Islands (Spratly) waters. The Pre-Cenozoic basement in the SCS and Yunkai continental area are coeval within the Tethyan tectonic domain in the Pre-Cenozoic Period. They are formed on the background of the Paleo-Tethyan tectonic domain, and are important components of the Eastern Tethyan multi-island-ocean system. Three branches of t...

2011-01-01

173

Asymptotic Safety, Asymptotic Darkness, and the hoop conjecture in the extreme UV

Amplitude preserved VSP reverse time migration for angle-domain CIGs extraction

Assuming the hoop conjecture in classical general relativity and quantum mechanics, any observer who attempts to perform an experiment in an arbitrarily small region will be stymied by the formation of a black hole within the spatial domain of the experiment. This behavior is often invoked in arguments for a fundamental minimum length. Extending a proof of the hoop conjecture for spherical symmetry to include higher curvature terms we investigate this minimum length argument when the gravitational couplings run with energy in the manner predicted by asymptotically safe gravity. We show that argument for the mandatory formation of a black hole within the domain of an experiment fails. Neither is there a proof that a black hole doesn't form. Instead, whether or not an observer can perform measurements in arbitrarily small regions depends on the specific numerical values of the couplings near the UV fixed point. We further argue that when an ...

2010-01-01

174

ASFIT-VARI: A practical gamma-ray transport code for MS-DOS computers

An improved method of generating angle-domain common-image gathers (ADCIGs) by VSP reverse time migration (RTM) is introduced in this paper. The formula which is used to compute the receiver wavefield for VSP RTM is modified by adding an amplitude correction term in order to conveniently output amplitude-preserved ADCIGs. Compared with the surface seismic data, VSP data contains much richer wavefields. However, the direct and downgoing waves can bring about serious imaging artifacts in ADCIGs, especially the direct wave. The feasibility and validity of this method is demonstrated by both numerical and real VSP data from western China. Thus, the ADCIGs from this method can provide reliable basic data for VSP migration velocity analysis, VSP AVO/AVA analysis, and inversion.

2011-06-01

175

A Novel Rough Set Reduct Algorithm for Medical Domain Based on Bee Colony Optimization

The ASFIT (Anisotropic Source-Flux Iteration Technique) code was first developed in India about 1970 to solve the radiation transport equation represented in the form of coupled integral equations separating the spatial and energy-angular transmissions. The ASFIT code uses a nodal structure in the wavelength [lambda] domain in Compton units (CU) rather than in the energy domain. The ASFIT-VARI code is the latest version available from the Radiation Shielding Information Center. It incorporates variable dimensioning and has been adapted for use on MS-DOS personal computers using the Ryan-McFarland or Microsoft Version 5.0 FORTRAN compilers. While earlier versions used point cross sections (well suited for gamma-ray transport), the present version also allows multigroup cross sections for neutron and coupled neutron-gamma-ray transport.

1990-01-01

176

cDNA Cloning of the Basement Membrane Chondroitin Sulfate Proteoglycan Core Protein, Bamacan: A Five Domain Structure Including Coiled-Coil Motifs

Feature selection refers to the problem of selecting relevant features which produce the most predictive outcome. In particular, feature selection task is involved in datasets containing huge number of features. Rough set theory has been one of the most successful methods used for feature selection. However, this method is still not able to find optimal subsets. This paper proposes a new feature selection method based on Rough set theory hybrid with Bee Colony Optimization (BCO) in an attempt to combat this. This proposed work is applied in the medical domain to find the minimal reducts and experimentally compared with the Quick Reduct, Entropy Based Reduct, and other hybrid Rough Set methods such as Genetic Algorithm (GA), Ant Colony Optimization (ACO) and Particle Swarm Optimization (PSO).

2010-01-01

177

Transport Properties of Doubly Periodic Arrays of Circular Cylinders and Optimal Design Problems

Basement membranes contain several proteoglycans, and those bearing heparan sulfate glycosaminoglycans such as perlecan and agrin usually predominate. Most mammalian basement membranes also contain...Full Text Available

1997-01-27

178

Transport Properties of Doubly Periodic Arrays of Circular Cylinders and Optimal Design Problems

We solve an R -linear problem for a multiple-connected circular domain in a class of doubly periodic functions in analytic form by a method of functional equations. This problem models transport properties of two-dimensional composite materials made from a collection of disks embedded in an otherwise uniform host.

2001-07-01

179

The renaissance of solar homes; Le renouveau des maisons solaires

We solve an R -linear problem for a multiple-connected circular domain in a class of doubly periodic functions in analytic form by a method of functional equations. This problem models transport properties of two-dimensional composite materials made from a collection of disks embedded in an otherwise uniform host.

2001-01-01

180

The nucleon axial charge in full lattice QCD

This publication of the Areva Group, a world nuclear industry leader, provides information on the energy in many domains. This issue deals with the nuclear fuel cycle, the biofuels, the everyday geothermal power, the Unites States energy supply and types, the Bertrand Picard solar aircraft, the kyoto protocol and the wind power leaders. A special chapter is devoted to the renaissance of solar homes. (A.L.B.)

2004-07-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

181

The application of MOX fuel in light water nuclear power plant

The nucleon axial charge is calculated as a function of the pion mass in full QCD. Using domain wall valence quarks and improved staggered sea quarks, we present the first calculation with pion masses as light as 354 MeV and volumes as large as (3.5 fm)3. We show that finite volume effects are small for our volumes and that a constrained fit based on finite volume chiral perturbation theory agrees with experiment within 5% statistical errors.

2005-10-13

182

The Acidic Domain of Hepatitis C Virus NS4A Contributes to RNA Replication and Virus Particle Assembly?

MOX fuel has been one of the mature nuclear fuels which can be used in light water nuclear power plant now. The development status in this domain in foreign countries, the major influence of MOX fuel on reactor performance and the countermeasures are introduced in this paper. The application of MOX fuel in China's PWR is discussed in the end. (authors)

2008-12-01

183

Hepatitis C virus NS3-4A is a membrane-bound enzyme complex that exhibits serine protease, RNA helicase, and RNA-stimulated ATPase activities. This enzyme complex is essential for viral genome replication...Full Text Available

2011-02-01

184

Tachyons

Synthesis and cloning of the genes of antisense peptides of human calcitonin and miniproinsulin

An interpretation of effects connected with the possible existence of tachyons, i.e. particles moving at a velocity higher than the velocity of light, is given. It is proposed that if there exist in nature particles with super-luminal velocities then they are likely to be found in domains of extremely small space-time intervals #DELTA#xx10"-"1"6cm and #DELTA#t<10"-"2"6s, in which processes involving a violation of spatial and temporal parities are playing an important role.

185

Suppression of afterglow in CsI:Tl by co doping with Eu"2"+-II: Theoretical model

With the aim of an experimental check on the validity of the theory of molecular recognition, the authors have carried out the chemical-enzymatic synthesis and cloning of the gene of human calcitonin and also of the genes of antisense polypeptides to human calcitonin and miniproinsulin. It has been shown that recombinant plasmids obtained on the basis of these synthetic genes are capable of ensuring the biosynthesis of the given polypeptides in E. coli cells as hybrid proteins with the IgG-binding domain of staphylococcal protein A.

1994-07-20

186

Supercomputers for solving PDE problems. Final report, 1 October 1985-31 March 1988

The mechanism for afterglow suppression in codoped CsI:Tl,Eu reported in the preceding paper was investigated by combined radioluminescence and thermoluminescence experiments. Model rate equations informed by these experiments were employed to simulate afterglow. It was found that codoping with europium introduces deep electron traps, with room-temperature glow peaks, that effectively scavenge the electrons from shallow traps associated with thallium, thus suppressing afterglow in the time domain of tens of milliseconds.

2006-03-15

187

Structural and Functional Investigations of Matrilin-1 A-domains Reveal Insights into Their Role in Cartilage ECM Assembly*

Researchers investigated several supercomputer architectures in the context of assessing their performance in solving PDE problems. Main results are: assessed various classes of paralled and vector supercomputers and parallel software issues toward solving PDE problems; developed a multipipeline networking technique for compound vector processing; developed an orthogonal multiprocessor for large-grain scientific computations; improved parallel efficiency of a domain decomposition method, the DD algorithm.

1988-11-01

188

Settlement instrumentation to observe open-pit mine backfill and a prototype foundation in western Canada

Matrilin-1 is expressed predominantly in cartilage and co-localizes with matrilin-3 with which it can form hetero-oligomers. We recently described novel structural and functional features of the matrilin-3...Full Text Available

2010-10-29

189

Search for tachyons associated with extensive air showers in the ground level cosmic radiation

It is necessary that reclaimed land from open pit mining operations has completely settled before it can be returned to the public domain. This paper reports on instrumentation installed to observe settlement of the spoil and behaviour of a prototype foundation on reclaimed land in Alberta, Canada. 6 refs., 7 figs.

1987-11-01

190

Scyl1 Facilitates Nuclear tRNA Export in Mammalian Cells by Acting at the Nuclear Pore Complex

Events detected in a shielded plastic scintillation counter occurring in the 26 microsec preceding the arrival of an extensive air shower at ground level with local electron density or = 20 m to the -2 power and the 240 microsec after its arrival have been studied. No significant excess of events (tachyons) arriving in the early time domain have been observed in a sample of 11,585 air shower triggers.

1985-08-01

191

Relativistic kinetics of baryon production in the big bang

Scyl1 is an evolutionarily conserved N-terminal protein kinase-like domain protein that plays a role in COP1-mediated retrograde protein trafficking in mammalian cells. Furthermore, loss of Scyl1 function...Full Text Available

2010-07-15

192

Regulation of cell proliferation and apoptosis in neuroblastoma cells by ccp1, a FGF2 downstream gene

The baryogenesis process in the early hot universe is investigated by means of relativistic kinetic theory. An exact solution to the kinetic equations for supermassive bosons serves to refine previous results: the optimum baryon-production domain is now complemented by bosons of low mass, thus removing the cosmological lower bound that had limited the mass of superheavy bosons. 14 references.

1985-08-01

193

Quantum Afterburner Improving the Efficiency of an Ideal Heat Engine

BackgroundCoiled-coil domain containing 115 (Ccdc115) or coiled coil protein-1 (ccp1) was previously identified as a downstream gene of Fibroblast Growth Factor 2 (FGF2) highly expressed...Full Text Available

194

Polymer electrolytes based on aromatic lithium sulfonyl-imide compounds; Electrolytes polymeres a base de sulfonylimidures de lithium aromatiques

By using a laser and maser in tandem, it is possible to obtain laser action in the hot exhaust gases involved in heat engine operation. Such a "quantum afterburner" involves the internal quantum states of working gas atoms or molecules as well as the techniques of cavity quantum electrodynamics and is therefore in the domain of quantum thermodynamics. As an example, it is shown that Otto cycle engine performance can be improved beyond that of the "ideal" Otto heat engine.

2002-01-01

195

P130Cas Src-Binding and Substrate Domains Have Distinct Roles in Sustaining Focal Adhesion Disassembly and Promoting Cell Migration

This paper presents ionic conductivity results obtained with polymer electrolytes and also with propylene carbonate solutions. The domain of electrochemical activity of this salt has been determined using cycle volt-amperometry in propylene carbonate. Preliminary experiments on the stability of the polymer electrolyte with respect to the lithium electrode have been carried out for a possible subsequent use in lithium batteries. (J.S.) 4 refs.

1996-12-31

196

Optical Fiber Sensors from Laboratory to Field Trials: Applications and Trends at CEA LIST

The docking protein p130Cas is a prominent Src substrate found in focal adhesions (FAs) and is implicated in regulating critical aspects of cell motility including FA disassembly and protrusion of the...Full Text Available

197

British Library Electronic Table of Contents (United Kingdom)

Fiber optic metrology developed at the CEA LIST laboratories involves fiber Bragg grating sensors, distributed Brillouin optical time domain reflectometry and optically stimulated luminescence dosimetry. Recent activities in optical fiber sensing are reviewed from laboratory experiments to field trials.

2009-01-01

198

On stochastic approximation algorithms for classes of PAC learning problems

On some problems caused by wavelet filtering in calculated spectra

The classical stochastic approximation methods are shown to yield algorithms to solve several formulations of the PAC learning problem defined on the domain [o,1]{sup d}. Under some assumptions on different ability of the probability measure functions, simple algorithms to solve some PAC learning problems are proposed based on networks of non-polynomial units (e.g. artificial neural networks). Conditions on the sizes of these samples required to ensure the error bounds are derived using martingale inequalities.

1994-03-01

199

Nucleon electromagnetic form factors from lattice QCD using 2+1 flavor domain wall fermions on fine lattices and chiral perturbation theory

It is shown that de-noising a measured time signal by wavelet technique produces a rather good result in time domain, while it has unwanted consequences in spectrum estimation. Therefore it can be used for reconstruction of the picture of the physical process, but it should be avoided, when the aim is to reveal eigenfrequencies or transient behaviour of the spectra.

1999-08-01

200

Nuclear receptor co-repressor SMRT regulates mitochondrial oxidative metabolism and mediates aging related metabolic deterioration

We present a high-statistics calculation of nucleon electromagnetic form factors in N{sub f}=2+1 lattice QCD using domain wall quarks on fine lattices, to attain a new level of precision in systematic and statistical errors. Our calculations use 32{sup 3}x64 lattices with lattice spacing a=0.084 fm for pion masses of 297, 355, and 403 MeV, and we perform an overdetermined analysis using on the order of 3600 to 7000 measurements to calculate nucleon electric and magnetic form factors up to Q{sup 2{approx_equal}}1.05 GeV{sup 2}. Results are shown to be consistent with those obtained using valence domain wall quarks with improved staggered sea quarks, and using coarse domain wall lattices. We determine the isovector Dirac radius r{sub 1}{sup v}, Pauli radius r{sub 2}{sup v} and anomalous magnetic moment {kappa}{sub v}. We also determine connected contributions to the corresponding isoscalar observables. We extrapolate these ...

2010-02-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

201

Mutational Analysis of the Carboxy-Terminal (YGX)₄ Repeat Domain of CpsD, an Autophosphorylating Tyrosine Kinase Required for Capsule Biosynthesis in Streptococcus pneumoniae

SummaryThe transcriptional co-repressor SMRT utilizes two major receptor interacting domains (RID1 and RID2) to mediate nuclear receptor (NR) signaling through epigenetic modification....Full Text Available

2010-12-01

202

Molecular recognition of nitrated fatty acids by PPAR[gamma

In Streptococcus pneumoniae, CpsB, CpsC, and CpsD are essential for encapsulation, and mutants containing deletions of cpsB, cpsC, or cpsD...Full Text Available

2003-05-01

203

Molecular basis of factor VIII inhibition by human antibodies. Antibodies that bind to the factor VIII light chain prevent the interaction of factor VIII with phospholipid.

Peroxisome proliferator activated receptor-{gamma} (PPAR{gamma}) regulates metabolic homeostasis and adipocyte differentiation, and it is activated by oxidized and nitrated fatty acids. Here we report the crystal structure of the PPAR{gamma} ligand binding domain bound to nitrated linoleic acid, a potent endogenous ligand of PPAR{gamma}. Structural and functional studies of receptor-ligand interactions reveal the molecular basis of PPAR{gamma} discrimination of various naturally occurring fatty acid derivatives.

2010-03-08

204

Magnetization and magnetostriction curves for highly magnetostrictive materials

Most antibodies to factor VIII have recently been shown to react with discrete regions of the factor VIII light chain (within the C2 domain) and/or the factor VIII heavy chain (within the amino-terminal...Full Text Available

1989-06-01

205

Localized Rayleigh Instability in Evaporation Fronts

The macroscopic behavior of magnetostrictive materials results from domain evolutions occurring at a microscopic scale. The author shows how to compute magnetization and magnetostriction curves by appraising the behavior of the underlying microstructures. The method hinges on an averaging device (Young measures), which allows one to pass from the microscopic to the macroscopic scale. He takes into account the kinematical constraints on the accommodation of elastic effects, and he highlights the role of material symmetry in the selection of energetically optimal microstructures.

1994-12-31

206

Interaction of Extracellular Domain 2 of the Human Retina-specific ATP-binding Cassette Transporter (ABCA4) with All-trans-retinal*

A qualitatively different manifestation of the Rayleigh instability is demonstrated, where, instead of the usual extended undulations and breakup of the liquid into many droplets, the instability is localized, leading to an isolated narrowing of the liquid filament. The localized instability, caused by a nonuniform curvature of the liquid domain, plays a key role in the evaporation of thin liquid films off solid surfaces.

2009-01-01

207

Human thrombomodulin gene is intron depleted: nucleic acid sequences of the cDNA and gene predict protein structure and suggest sites of regulatory control.

The retina-specific ATP-binding cassette (ABC) transporter, ABCA4, is essential for transport of all-trans-retinal from the rod outer segment discs in the retina and is associated with...Full Text Available

2010-06-18

208

Helper T-Cell Epitopes Encoded by the Babesia bigemina rap-1 Gene Family in the Constant and Variant Domains Are Conserved among Parasite Strains

We have isolated a human thrombomodulin cDNA, and a human genomic clone containing the putative promoter domain, as well as the translated and untranslated regions of the endothelial cell receptor....Full Text Available

1987-09-01

209

Glutamine-linked and Non-consensus Asparagine-linked Oligosaccharides Present in Human Recombinant Antibodies Define Novel Protein Glycosylation Motifs

Among important candidates for babesial vaccines are apical complex proteins, including rhoptry-associated protein 1 (RAP-1) from Babesia bovis and B. bigemina, which...Full Text Available

1998-04-01

210

Fault diagnosis of rolling bearing based on cyclic spectrum density

We report the presence of oligosaccharide structures on a glutamine residue present in the V_L domain sequence of a recombinant human IgG2 molecule. Residue Gln-106, present in the QGT sequence...Full Text Available

2010-05-21

211

Expression of Genes Encoding F₁-ATPase Results in Uncoupling of Glycolysis from Biomass Production in Lactococcus lactis

The paper considered the vibration signals of rotating equipment as cyclo stationary signals through analyzing the features of this kind of signals. Based on the analytic method of cyclic spectrum density, the paper pointed out that the impact frequency could be extracted effectively with the help of scanning cyclic frequency domain. The validity of the method of cyclic spectrum density is proved by simulating signals and the method is applied to the diagnosis of rolling bearings. (authors)

2009-09-01

212

Exploring the structural dynamics of the E. coli chaperonin GroEL using translation-libration-screw crystallographic refinement of intermediate states

We studied how the introduction of an additional ATP-consuming reaction affects the metabolic fluxes in Lactococcus lactis. Genes encoding the hydrolytic part of the F₁ domain...Full Text Available

2002-09-01

213

Crystal structures of the N-terminal kinase domain of human RSK1 bound to three different ligands: Implications for the design of RSK1 specific inhibitors

Large rigid-body domain movements are critical to GroEL-mediated protein folding, especially apical domain elevation and twist associated with the formation of a folding chamber upon binding ATP and co-chaperonin GroES. Here, we have modeled the anisotropic displacements of GroEL domains from various crystallized states, unliganded GroEL, ATP?S-bound, ADP-AlFx/GroES-bound, and ADP/GroES bound, using translation-libration-screw (TLS) analysis. Remarkably, the TLS results show that the inherent motions of unliganded GroEL, a polypeptide-accepting state, are biased along the transition pathway that leads to the folding-active state. In the ADP-AlFx/GroES-bound folding-active state the dynamic modes of the apical domains become reoriented and coupled to the motions of bound GroES. The ADP/GroES complex exhibits these same motions, but they are increased in magnitude, potentially reflecting the decreased ...

2004-08-12

214

Computer Algebra meets Finite Elements: an Efficient Implementation for Maxwell's Equations

The p90 ribosomal S6 kinases (RSKs) also known as MAPKAP-Ks are serine/threonine protein kinases that are activated by ERK or PDK1 and act as downstream effectors of mitogen-activated protein kinase...Full Text Available

2007-12-01

215

Cellular DNA region involved in induction of thymic lymphomas (Mlvi-2) maps to mouse chromosome 15.

We consider the numerical discretization of the time-domain Maxwell's equations with an energy-conserving discontinuous Galerkin finite element formulation. This particular formulation allows for higher order approximations of the electric and magnetic field. Special emphasis is placed on an efficient implementation which is achieved by taking advantage of recurrence properties and the tensor-product structure of the chosen shape functions. These recurrences have been derived symbolically with computer algebra methods reminiscent of the holonomic systems approach.

2011-01-01

216

Cadmium down-regulation of kidney Sp1 binding to mouse SGLT1 and SGLT2 gene promoters: Possible reaction of cadmium with the zinc finger domain of Sp1

Two cellular DNA regions representing common domains for proviral DNA integration ( Mlvi -1 and Mlvi -2) have been identified in Moloney murine leukemia virus-induced rat thymic lymphomas. Cellular...Full Text Available

1984-05-01

217

Attractors for nonlinear reaction-diffusion systems in unbounded domains via the method of short trajectories

Cadmium (Cd) exposure causes glucosuria (glucose in the urine). Previously, it was shown that Cd exposure of primary cultures of mouse kidney cells (PMKC) decreased mRNA levels of the glucose...Full Text Available

2010-05-01

218

Application of power system stabilizers and static VAR compensators on a longitudinal power system

We consider a nonlinear reaction-diffusion equation settled on the whole euclidean space. We prove the well-posedness of the corresponding Cauchy problem in a general functional setting, namely, when the initial datum is uniformly locally bounded in L^2. Then we adapt the short trajectory method to establish the existence of the global attractor and, if the space dimension is at most 3, we also find an upper bound of its Kolmogorov's entropy.

2009-01-01

219

Analysis of the murine All-1 gene reveals conserved domains with human ALL-1 and identifies a motif shared with DNA methyltransferases.

Dynamic stability improvement of a longitudinal power system using a power system stabilizer (PSS) and a static VAR compensator (SVC) is reported in this paper. An analytical approach is developed for the determination of PSS parameters. Results from time domain simulations indicate that the PSS and the SVC are very effective in damping system oscillations.

1988-11-01

220

Amino acid sequences that determine the nuclear localization of yeast histone 2B.

A series of translocation break points found in a subset of human acute leukemias have one of the breaks on human chromosome 11q23. This region has recently been cloned and a large gene, ALL-1, with...Full Text Available

1993-07-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

221

Adenine and guanine recognition of stop codon is mediated by different N domain conformations of translation termination factor eRF1

Histone-beta-galactosidase protein fusions were used to identify the domain of yeast histone 2B, which targets this protein to the nucleus. Amino acids 28 to 33 in H2B were required for nuclear localization...Full Text Available

1987-11-01

222

Activity report 2001; Rapport annuel d'activite 2001

Positioning of release factor eRF1 toward adenines and the ribose-phosphate backbone of the UAAA stop signal in the ribosomal decoding site was studied using messenger RNA (mRNA) analogs containing...Full Text Available

2011-09-01

223

ADS as Information Management Service in an M-Learning Environment

The DED, Department of the Wastes Studies, part of the Direction of the Nuclear Energy of the CEA, regroups knowledge in the domain of the chemistry, the biochemistry, the process measures and simulation engineering applied to the radioactive wastes management. This annual report presents for the year 2001 the missions, the organization, the scientific collaborations, the research programs and the publications of the Department. (A.L.B.)

2001-07-01

224

A region in the cytosolic domain of the epidermal growth factor receptor antithetically regulates the stimulatory and inhibitory guanine nucleotide-binding regulatory proteins of adenylyl cyclase.

Leveraging the potential power of even small handheld devices able to communicate wirelessly requires dedicated support. In particular, collaborative applications need sophisticated assistance in terms of querying and exchanging different kinds of data. Using a concrete example from the domain of mobile learning, the general need for information dissemination is motivated. Subsequently, and driven by infrastructural conditions, realization strategies of an appropriate middleware service are discussed.

2007-01-01

225

A method of fundamental solutions for the one-dimensional inverse Stefan problem

Epidermal growth factor (EGF) stimulates adenylyl cyclase in the heart via activation of the stimulatory GTP-binding protein Gs. Therefore, employing peptides corresponding to regions in the cytosolic...Full Text Available

1995-03-14

226

British Library Electronic Table of Contents (United Kingdom)

We investigate an application of the method of fundamental solutions (MFS) to the one-dimensional inverse Stefan problem for the heat equation by extending the MFS proposed in [5] for the one-dimensional direct Stefan problem. The sources are placed outside the space domain of interest and in the time interval (-T,T). Theoretical properties of the method, as well as numerical investigations, are included, showing that accurate and stable results can be obtained efficiently with small computational cost.

2011-01-01

227

A Single Domain Llama Antibody Potently Inhibits the Enzymatic Activity of Botulinum Neurotoxin by Binding to the Non-Catalytic Alpha-Exosite Binding Region

A C-terminal Sequence in the Guanine Nucleotide Exchange Factor Sec7 Mediates Golgi Association and Interaction with the Rsp5 Ubiquitin Ligase*

Ingestion or inhalation of botulinum neurotoxin (BoNT) results in botulism, a severe and frequently fatal disease. Current treatments rely on antitoxins, which while effective cannot reverse...Full Text Available

2010-04-09

228

3-D numerical simulation of the transient electromagnetic pulse coupling to double cylinder object

Arf GTPases control vesicle formation from different intracellular membranes and are regulated by Arf guanine nucleotide exchange factors (GEFs). Outside of their conserved catalytic domains, known...Full Text Available

2008-12-05

229

Vibration test report on the instrumented capsule for fuel irradiation test

In this paper, finite-difference time-domain method is used to research the transient electromagnetic pulse (EMP) coupling to the cylinder object which is shielded in another shielding cavity with a hole numerically. The different coupling effectiveness of three transient EMP is simulated. The distribution of the electric field in the shielding cavity and the current on the cavity are researched. The shielding effectiveness is evaluated. (authors)

2006-10-21

230

Thomson Scattering at FLASH - Status Report

The fluid-induced vibration level of instrumented capsule, which was manufactured for fuel irradiation test at the reactor core of HANARO, was investigated. For this purpose, the instrumented capsule was loaded at the OR site of the HANARO design verification test facility that could simulate identical flow condition as the HANARO core. Then, vibration signals of the instrumented capsule subjected to various flow conditions were measured by using vibration sensors. In time domain analysis, maximum amplitudes and RMS values of the measured acceleration and displacement signals were obtained. By using frequency domain analysis, frequency components of the fluid-induced vibration were analyzed. In addition, natural frequencies of the instrumented capsule were obtained by performing modal test. The frequency analysis results showed that the natural frequency components near 7.5Hz and 17.5Hz were dominant in the fluid-induced vibration signal. The ...

2003-01-01

231

The importance of turbulence modelling in the design of a novel delivery system for a single-belt steel casting process

The basic idea is to implement Thomson scattering with free electron laser (FEL) radiation at near-solid density plasmas as a diagnostic method which allows the determination of plasma temperatures and densities in the warm dense matter (WDM) regime (free electron density of n{sub e} = 10{sup 21}-10{sup 26} cm{sup -3} with temperatures of several eV). The WDM regime [1] at near-solid density (n{sub e} = 10{sup 21}-10{sup 22} cm{sup -3}) is of special interest because, it is where the transition from an ideal plasma to a degenerate, strongly coupled plasma occurs. A systematic understanding of this largely unknown WDM domain is crucial for the modeling and understanding of contemporary plasma experiments, like laser shock-wave or Z-pinch experiments as well as for inertial confinement fusion (ICF) experiments as the plasma evolution follows its path through this domain.

2007-11-28

232

Study of structural and optical properties of sprayed WO{sub 3} thin films using enhanced characterization techniques along with the Boubaker Polynomials Expansion Scheme (BPES)

In this work, a comprehensive model including heat transfer, fluid flow and solidification was used to evaluate the performance of a novel delivery system for a single-belt steel casting process. This near-net-shape casting, although still in development, is one of the most promising routes for casting of low-carbon steel in large scale. This paper focuses on the performance of a low-Re {kappa}-{epsilon} model that was employed to simulate the three-dimensional turbulent flows fully-coupled with heat transfer and macroscopic solidification. Simulations were run for the intended conditions of caster operation, and the results obtained with the {kappa}-{epsilon} were compared with the results obtained with an ad hoc viscosity model, where the molecular viscosity was boosted 100 times, uniformly throughout the computational domain. A semi-analytical solution was employed for validating the models and the results showed that the ad hoc viscosity model overestimated the ...

2000-01-01

233

Study of structural and optical properties of sprayed WO3 thin films using enhanced characterization techniques along with the Boubaker Polynomials Expansion Scheme (BPES)

In this study, WO{sub 3} thin films were grown on glass substrates using an aqueous solution containing tungstate (NH{sub 4}){sub 2}WO{sub 4} as precursor. The substrate temperature incremented from 250 to 500 deg. C, by steps of 50 deg. C. The structural properties were investigated using XRD, atomic force microscopy and scanning electronic microscopy techniques. Microprobe analyses showed that a balanced stoichiometric composition was obtained for thin films prepared at T{sub s} = 350 and 400 deg. C. The X-ray diffraction analyses showed different structure crystallography in function of the substrate temperature. Moreover, films deposited at 400 deg. C were annealed in air for 2 h at 450 and 500 deg. C, respectively and the structural changes due to heat treatment were studied. Finally, the optical properties of these films were carried out using optical measurements of transmittance T({lambda}) and reflectance R({lambda}) spectra in 300-1800 nm domain. The ...

2009-11-13

234

Study of degradation diagnosis for low voltage cable aged by thermal and radiation with time domain dielectric spectrometer

In this study, WO3 thin films were grown on glass substrates using an aqueous solution containing tungstate (NH4)2WO4 as precursor. The substrate temperature incremented from 250 to 500 deg. C, by steps of 50 deg. C. The structural properties were investigated using XRD, atomic force microscopy and scanning electronic microscopy techniques. Microprobe analyses showed that a balanced stoichiometric composition was obtained for thin films prepared at Ts = 350 and 400 deg. C. The X-ray diffraction analyses showed different structure crystallography in function of the substrate temperature. Moreover, films deposited at 400 deg. C were annealed in air for 2 h at 450 and 500 deg. C, respectively and the structural changes due to heat treatment were studied. Finally, the optical properties of these films were carried out using optical measurements of transmittance T(?) and reflectance R(?) spectra in 300-1800 nm domain. The refractive and absorption indexes, n and k were ...

2009-11-13

235

Structured Interview of Personality Organization (STIPO): preliminary psychometrics in a clinical sample.

Non-destructive methods of diagnosis for detecting cable degradation by aging are being studied recently for improvement of electric wires and cables. This study examines degradation behaviors of cable sheath and insulation by combined accelerated aging tests applying thermal and radiation stresses simultaneously using a typical low voltage cable. According to experiments, elongation of cross-linked polyethylene insulation deteriorated at a faster rate than PVC sheath did under low doses below 50 Gy/h. Therefore, measurements using a time domain dielectric spectrometer (TDS) were carried out for the purpose of developing a method of degradation diagnosis of insulation. It was found that values of tan#delta# measured at very low frequencies below 0.1 Hz increase in pace with degradation of insulation reflecting the level of degradation more effectively than those measured at frequencies around the commercial frequency. In order to consider causes of the increases of ...

2000-05-01

236

Reverse time migration for ground penetrating radar using finite difference time domain method; Jikan ryoiki yugenn sabunho ni yoru chichu reda no ribasu taimu maigureshon

In this article, we describe the development and preliminary psychometric properties of the Structured Interview of Personality Organization (STIPO), a semistructured interview designed for the dimensional assessment of identity, primitive defenses, and reality testing, the three primary content domains in the model of personality health and disorder elaborated by Kernberg (1984; Kernberg & Caligor, 2005). Results of this investigation, conducted in a clinical sample representing a broad range of personality pathology, indicate that identity and primitive defenses as operationalized in the STIPO are internally consistent and that interrater reliability for all 3 content domains is adequate. Validity findings suggest that the assessment of one's sense of self and significant others (Identity) is predictive of measures of positive and negative affect, whereas the maladaptive ways in which the subject uses his or her objects for purposes of ...

2010-01-01

237

Rearrangement of a common cellular DNA domain on chromosome 4 in human primary liver tumors

The reversion time migration, as one of reflection seismic prospecting migration, reverse propagates a wave equation by reverse promoting the differential time, and conducts the migration. The method has such merits as no limit to the inclined angle of a reflection, correspondence to a complex topography etc. And, there is a finite difference time domain (FDTD) that uses the Maxwell equation as it is and makes a difference approximation in the methods differentiating and resolving electro-magnetic fields. It is also possible to apply the reverse time migration onto it. In this speech, using an explosive reflection face, a slope 2 layer structure and models of its reflection points are synthesized by a ground penetrating radar using the FDTD, and reverse time migration is conducted. As a result, it is clarified that the reverse time migration is valid for the ground penetrating radar recording. And, the cases including a diffusion item in the equation are also ...

1999-02-01

238

Rearrangement of a common cellular DNA domain on chromosome 4 in human primary liver tumors

Hepatitis B virus (HBV) DNA integration has been shown to occur frequently in human hepatocellular carcinomas. The authors have investigated whether common cellular DNA domains might be rearranged, possibly by HBV integration, in human primary liver tumors. Unique cellular DNA sequences adjacent to an HBV integration site were isolated from a patient with hepatitis B surface antigen-positive hepatocellular carcinoma. These probes detected rearrangement of this cellular region of chromosomal DNA in 3 of 50 additional primary liver tumors studied. Of these three tumor samples, two contained HBV DNA, without an apparent link between the viral DNA and the rearranged allele; HBV DNA sequences were not detected in the third tumor sample. By use of a panel of somatic cell hybrids, these unique cellular DNA sequences were shown to be located on chromosome 4. Therefore, this region of chromosomal DNA might be implicated in the formation of different tumors at one step of ...

1988-02-01

239

Preparation of Permalloy nanostructures using focused ion beam methods

Hepatitis B virus (HBV) DNA integration has been shown to occur frequently in human hepatocellular carcinomas. The authors have investigated whether common cellular DNA domains might be rearranged, possibly by HBV integration, in human primary liver tumors. Unique cellular DNA sequences adjacent to an HBV integration site were isolated from a patient with hepatitis B surface antigen-positive hepatocellular carcinoma. These probes detected rearrangement of this cellular region of chromosomal DNA in 3 of 50 additional primary liver tumors studied. Of these three tumor samples, two contained HBV DNA, without an apparent link between the viral DNA and the rearranged allele; HBV DNA sequences were not detected in the third tumor sample. By use of a panel of somatic cell hybrids, these unique cellular DNA sequences were shown to be located on chromosome 4. Therefore, this region of chromosomal DNA might be implicated in the formation of different tumors at one step of ...

240

Physics of the {sup 252}Cf-source-driven noise analysis measurement

Focused ion beam (FIB) milling is a powerful and versatile tool for the maskless fabrication of structures and devices at micro- and nanometer scales. The approach is based on the milling and deposition capabilities of a focused ion beam, where the latter is achieved by ion-beam-assisted decomposition of a metalorganic gas precursor of the specific material that has to be deposited. The combination of FIB and scanning electron microscopy in the same unit (so-called dual-beam unit) further expands the capabilities of the approach by the possibility of performing electron-beam-assisted deposition and inspection. Permalloy nanowires with electrical contacts patterned by FIB-Pt deposition were prepared in the dual-beam unit. Various types of notches to pin magnetic domain walls were additionally fabricated by means of FIB. The fabrication parameters for a structural modification of the Permalloy structures without too strongly affecting the material properties were ...

2010-03-21

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

241

PSS and TCSC damping controller coordinated design using PSO in multi-machine power system

The {sup 252}Cf-source-driven noise analysis method is a versatile measurements tool that has been applied to measurements for initial loading of reactors, quality assurance of reactor fuel elements, fuel processing facilities, fuel reprocessing facilities, fuel storage facilities, zero-power testing of reactors, verification of calculational methods, process monitoring, characterization of storage vaults, and nuclear weapons identification. This method`s broad range of application is due to the wide variety of time- and frequency domain signatures, each with unique properties, obtained from the measurement. The following parameters are obtained from this measurement: average detector count rates, detector multiplicities, detector autocorrelations, cross-correlation between detectors, detector autopower spectral densities, cross-power spectral densities between detectors, coherences, and ratios of spectral densities. All of these measured parameters can also be ...

1997-02-01

242

Optimal Control of Thermo--Fluid Phenomena in Variable Domains

The paper develops a new design procedure for simultaneous coordinated designing of the thyristor controlled series capacitor (TCSC) damping controller and power system stabilizer (PSS) in multi-machine power system. The coordinated design problem of PSS and TCSC damping controllers over a wide range of loading conditions is converted to an optimization problem with the time domain-based objective function that is solved by a particle swarm optimization (PSO) technique which has a strong ability to find the most optimistic results. By minimizing the proposed fitness function in which oscillatory characteristics between areas are included and thus the interactions among the TCSC controller and PSS under transient conditions in the multi-machine power system are improved. To ensure the robustness of the proposed stabilizers, the design process takes a wide range of operating conditions into account. The effectiveness of the proposed controller is demonstrated through ...

2010-12-01

243

Implementing Explicit and Finding Implicit Sharing in Embedded DSLs

This presentation concerns our continued research on adjoint--based optimization of viscous incompressible flows (the Navier--Stokes problem) coupled with heat conduction involving change of phase (the Stefan problem), and occurring in domains with variable boundaries. This problem is motivated by optimization of advanced welding techniques used in automotive manufacturing, where the goal is to determine an optimal heat input, so as to obtain a desired shape of the weld pool surface upon solidification. We argue that computation of sensitivities (gradients) in such free--boundary problems requires the use of the shape--differential calculus as a key ingredient. We also show that, with such tools available, the computational solution of the direct and inverse (optimization) problems can in fact be achieved in a similar manner and in a comparable computational time. Our presentation will address certain mathematical and computational aspects of the method. As an ...

2008-11-01

244

Identification of the binding domain for NADP"+ of human glucose-6-phosphate dehydrogenase by sequence analysis of mutants

Aliasing, or sharing, is prominent in many domains, denoting that two differently-named objects are in fact identical: a change in one object (memory cell, circuit terminal, disk block) is instantly reflected in the other. Languages for modelling such domains should let the programmer explicitly define the sharing among objects or expressions. A DSL compiler may find other identical expressions and share them, implicitly. Such common subexpression elimination is crucial to the efficient implementation of DSLs. Sharing is tricky in embedded DSL, since host aliasing may correspond to copying of the underlying objects rather than their sharing. This tutorial summarizes discussions of implementing sharing in Haskell DSLs for automotive embedded systems and hardware description languages. The technique has since been used in a Haskell SAT solver and the DSL for music synthesis. We demonstrate the embedding in pure Haskell of a simple DSL with a ...

2011-01-01

245

Identification of protein phosphorylation sites within Ser/Thr-rich cluster domains using site-directed mutagenesis and hybrid linear quadrupole ion trap Fourier transform ion cyclotron resonance mass spectrometry

Human erythrocyte glucose-6-phosphate is normally quite stable in the presence of 10 #mu#M NADP"+. Certain glucose-6-phosphate dehydrogenase variants lose virtually all their activity at this concentration of NADP"+ but are reactivated by 200 #mu#M NADP"+. Such variants presumably have a defect in their NADP"+-binding site. The authors analyzed the sequence of cDNA or genomic DNA from seven unrelated patients with hemolytic anemia due to the inheritance of variants that are reactivated by NADP"+. Six patients had substitutions of one of three adjacent amino acids, and the seventh patient had another amino acid substitution 23 residues downstream. These amino acids are highly conserved, all being present in rat and all but one being found also in Drosophila. The anomalous electrophoretic behavior of some of the variants can be explained by their loss of ability to bind NADP"+. The conclude that the region in which these mutations occur defines the binding domain for ...

246

British Library Electronic Table of Contents (United Kingdom)

We describe a method for the analysis of multi-site phosphorylation in serine/threonine (Ser/Thr)-rich protein sequences. Site-specific mutagenesis was used to introduce tryptic cleavage sites in the serine glutamine/threonine glutamine cluster domain (SCD) of the human checkpoint protein kinase (Chk2). The mutant proteins were shown to autophosphorylate on residues that are inducibly phosphorylated when mammalian cells are exposed to ionizing radiation (serine 33/35, serine 516, threonine 68 and threonine 432). Five Ser/Thr clusters within the SCD were flanked by arginine or lysine residues to produce tryptic peptides for nanospray liquid chromatography (nanoLC)/linear quadrupole ion trap Fourier transform ion cyclotron resonance mass spectrometry. Phosphorylation sites were assigned usin...

2007-01-01

247

Homology analyses of the protein sequences of fatty acid synthases from chicken liver, rat mammary gland, and yeast

Hilbert problem for a multiply connected circular domain and the analysis of the Hall effect in a plate

Homology analyses of the protein sequences of chicken liver and rat mammary gland fatty acid synthases were carried out. The amino acid sequences of the chicken and rat enzymes are 67% identical. If conservative substitutions are allowed, 78% of the amino acids are matched. A region of low homologies exists between the functional domains, in particular around amino acid residues 1059-1264 of the chicken enzyme. Homologies between the active sites of chicken and rat and of chicken and yeast enzymes have been analyzed by an alignment method. A high degree of homology exists between the active sites of the chicken and rat enzymes. However, the chicken and yeast enzymes show a lower degree of homology. The DADPH-binding dinucleotide folds of the {beta}-ketoacyl reductase and the enoyl reductase sites were identified by comparison with a known consensus sequence for the DADP- and FAD-binding dinucleotide folds. The active sites of all of the enzymes are primarily in ...

1989-11-01

248

High temperature deformation behavior of AZ31 Mg alloy

In this paper we analyze the Hilbert boundary-value problem of the theory of analytic functions for an $(N+1)$-connected circular domain. An exact series-form solution has already been derived for the case of continuous coefficients. Motivated by the study of the Hall effect in a multiply connected plate we extend these results by examining the case of discontinuous coefficients. The Hilbert problem maps into the Riemann-Hilbert problem for symmetric piece-wise meromorphic functions invariant with respect to a symmetric Schottky group. The solution to this problem is derived in terms of two analogues of the Cauchy kernel, quasiautomorphic and quasimultiplicative kernels. The former kernel is known for any symmetry Schottky group. We prove the existence theorem for the second, quasimultiplicative, kernel for any Schottky group (its series representation is known for the first class groups only). We also show that the use of an automorphic kernel requires the ...

2009-01-01

249

Groundwater travel time uncertainty analysis. Sensitivity of results to model geometry, and correlations and cross correlations among input parameters

High temperature deformation behavior of AZ31 Mg alloy was investigated in this study on the basis of a processing map ({epsilon} {approx} 0.6). To construct a processing map, compression tests were carried out at various temperatures and strain rates. Two regions of high deformation efficiency ({eta}) were identified as: (1) a dynamic recrystallization (DRX) domain at 250 C and 1/s and (2) a superplasticity domain at 450 C and 10{sup -4}/s. The average grain size observed in the DRX region was considerably smaller (2.9{mu}m) than in any other region. In the superplastic condition, tensile elongation to failure approached to 1040%. At the high Z regions, flow softening occurred resulting from the dynamic recrystallization but below 10{sup 10} of Z value, flow hardening occurred due to the grain growth. Possible deformation mechanisms operating at high temperature were discussed in relation to the activation energy. A two-stage deformation ...

2005-07-01

250

Generalized Collective Inference with Symmetric Clique Potentials

This study examines the sensitivity of the travel time distribution predicted by a reference case model to (1) scale of representation of the model parameters, (2) size of the model domain, (3) correlation range of log-transmissivity, and (4) cross correlations between transmissivity and effective thickness. The basis for the reference model is the preliminary stochastic travel time model previously documented by the Basalt Waste Isolation Project. Results of this study show the following. The variability of the predicted travel times can be adequately represented when the ratio between the size of the zones used to represent the model parameters and the log-transmissivity correlation range is less than about one-fifth. The size of the model domain and the types of boundary conditions can have a strong impact on the distribution of travel times. Longer log-transmissivity correlation ranges cause larger variability in the predicted travel times. ...

1985-03-01

251

Gear crack level identification based on weighted K nearest neighbor classification algorithm

Collective graphical models exploit inter-instance associative dependence to output more accurate labelings. However existing models support very limited kind of associativity which restricts accuracy gains. This paper makes two major contributions. First, we propose a general collective inference framework that biases data instances to agree on a set of {\\em properties} of their labelings. Agreement is encouraged through symmetric clique potentials. We show that rich properties leads to bigger gains, and present a systematic inference procedure for a large class of such properties. The procedure performs message passing on the cluster graph, where property-aware messages are computed with cluster specific algorithms. This provides an inference-only solution for domain adaptation. Our experiments on bibliographic information extraction illustrate significant test error reduction over unseen domains. Our second major contribution consists of ...

2009-01-01

252

Frequency-domain analysis of sound pressure oscillation in natural convective subcooled boiling system and its regime recognition

A crack fault is one of the damage modes most frequently occurring in gears. Identifying different crack levels, especially for early cracks is a challenge in gear fault diagnosis. This paper aims to propose a method to classify the different levels of gear cracks automatically and reliably. In this method, feature parameters in time domain, specially designed for gear damage detection and in frequency domain are extracted to characterize the gear conditions. A two-stage feature selection and weighting technique (TFSWT) via Euclidean distance evaluation technique (EDET) is presented and adopted to select sensitive features and remove fault-unrelated features. A weighted K nearest neighbor (WKNN) classification algorithm is utilized to identify the gear crack levels. The gear crack experiments were conducted and the vibration signals were captured from the gears under different loads and motor speeds. The proposed method is applied to ...

2009-07-01

253

Explicit representations of problem-solving strategies to support knowledge acquisition

The dynamical signals of sound pressure oscillation in natural convective subcooled boiling system are obtained by using computer data acquisition technique. Through frequency-domain analysis of typical dynamical data, combined with study on the acquired time series of sound pressure, are observed and explained. The time-frequency phenomena, such as the onset of shock wave, frequency doubling relation of sound pressure, combination of sound frequency spectrum peaks etc., which describe the characteristics of natural convective subcooled boiling system are presented. Furthermore, based on frequency spectra of sound pressure, related eigen vectors are defined and established and with dynamical clustering method, regime recognition for the dynamical process of system is carried out. Results of recognition are consistent with that of qualitative analysis of time series, which is of great significance for automatic monitoring system of nuclear safety, expertise ...

1998-12-01

254

Ectopic expression of wild-type or a dominant-negative mutant of transcription factor NTF-1 disrupts normal Drosophila development.

Role-limiting approaches support knowledge acquisition (KA) by centering knowledge base construction on common types of tasks or domain-independent problem-solving strategies. Within a particular problem-solving strategy, domain-dependent knowledge plays specific roles. A KA tool then helps a user to fill these roles. Although role-limiting approaches are useful for guiding KA, they are limited because they only support users in filling knowledge roles that have been built in by the designers of the KA system. EXPECT takes a different approach to KA by representing problem-solving knowledge explicitly, and deriving from the current knowledge base the knowledge gaps that must be resolved by the user during KA. This paper contrasts role-limiting approaches and EXPECT`s approach, using the propose-and-revise strategy as an example. EXPECT not only supports users in filling knowledge roles, but also provides support in making other modifications to ...

1996-12-31

255

Algorithmic aspects and supercomputing trends in computational electromagnetics

The Drosophila melanogaster tissue-specific transcription factor NTF-1 was originally identified in vitro as a protein that could bind to and activate transcription from the Dopa decarboxylase (Ddc) gene. A structure-function analysis of NTF-1 led to the identification of a discrete amino-terminal activation domain. Here, we report that an NTF-1 mutant lacking the activation domain acts as a trans-dominant inhibitor of NTF-1 activation in tissue culture cells by forming inactive heterodimers with the full-length protein. Ectopically expressing this dominant-negative protein or the full-length protein in developing Drosophila embryos leads to dire developmental consequences. Overexpressing the trans-dominant NTF-1 leads to lethality, while overexpressing full-length NTF-1 results in both lethality and morphogenetic defects. Our results suggest that both the activity and the regulation of NTF-1 are critical for viability and proper development of ...

1993-11-15

256

Topological Defects in the Moduli Sector of String Theory

Accurate and rapid evaluation of radar signature for alternative aircraft/store configurations would be of substantial benefit in the evolution of integrated designs that meet RCS requirements across the threat spectrum. Finite-volume time domain methods offer the possibility of modeling the whole aircraft, including penetrable regions and stores, at longer wavelengths on today's supercomputers and at typical airborne radar wavelengths on the teraflop computers of tomorrow. A structure-grid finite-volume time domain CFD based RCS code has already been developed at the Rockwell Science Center, and this code incorporates modeling techniques for general radar absorbing materials and structures. Using this work as a base, the goal of the CFD based CEM effort is to define, implement, and evaluate various code development issues suitable for rapid prototype signature prediction addressing many issues related to physics of electromagnetics, ...

1993-01-01

257

Theory and method for selection of power system stabilizer location

We point out that the moduli sector of the $(2,2)$ string compactification with its nonperturbatively preserved non-compact symmetries is a fertile framework to study global topological defects, thus providing a natural source for the large scale structure formation. Based on the target space modular invariance of the nonperturbative superpotential of the four-dimensional N=1 supersymmetric string vacua, topologically stable stringy domain walls are found. They are supersymmetric solutions, thus saturating the Bogomolnyi bound. It is also shown that there are moduli sectors that allow for the global monopole-type and texture-type configurations whose radial stability is ensured by higher derivative terms.

1991-01-01

258

The Geometry of Stable Quotients in Genus One

A new approach for the selection of best PSS locations in multimachine power systems is proposed in this paper. Study shows that the right-eigenvector measures the activity of state variables and the left-eigenvector measures the control effect of control signals. Based on the right and left eigenvector the concept of sensitivity of PSS effect (SPE) is presented and used to identify the best PSS locations. The proposed method is used to identify the best PSS location in a 13-machine system to increase the damping of an interarea mode. The time-domain simulation results confirm that the prediction of best PSS location by SPE method is correct and accurate.

1991-03-01

259

Terascale Optimal PDE Simulations (TOPS) Center

Stable quotient spaces provide an alternative to stable maps for compactifying spaces of maps. When the target is projective space and the domain curve has genus 1, these are smooth proper Deligne-Mumford stacks. In this paper we study the associated coarse moduli schemes. We show these schemes are projective, rationally connected and have Picard number 2. Then we give generators for the Picard group, compute the canonical divisor, and the cones of ample and effective divisors. In certain cases, we also give a closed formula for the Poincar\\'{e} polynomial.

2011-01-01

260

Structural and magnetic studies on the enhancement of the giant magnetoimpedance by ion irradiation

Our work has focused on the development and analysis of domain decomposition algorithms for a variety of problems arising in continuum mechanics modeling. In particular, we have extended and analyzed FETI-DP and BDDC algorithms; these iterative solvers were first introduced and studied by Charbel Farhat and his collaborators, see [11, 45, 12], and by Clark Dohrmann of SANDIA, Albuquerque, see [43, 2, 1], respectively. These two closely related families of methods are of particular interest since they are used more extensively than other iterative substructuring methods to solve very large and difficult problems. Thus, the FETI algorithms are part of the SALINAS system developed by the SANDIA National Laboratories for very large scale computations, and as already noted, BDDC was first developed by a SANDIA scientist, Dr. Clark Dohrmann. The FETI algorithms are also making inroads in commercial engineering software systems. We also note that the analysis of these ...

2007-07-09

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

261

British Library Electronic Table of Contents (United Kingdom)

The mechanism of abrupt increase of the giant magneto impedance (GMI) ratio in the ion irradiated Co-based amorphous ribbon has been investigated. The grazing incident X-ray diffraction and transmission electron microscope were used to characterize the samples before and after ion irradiation. The GMI-ratio considerably increased in the ion irradiated samples and the GMI response showed strong dependence on the driving frequencies. The Barkhausen noise (BN) signals are increased for the Ar ion irradiated sample with dose of 1x10^1^7 ion/cm^2. The results are interpreted in terms of GMI variation associated with domain wall dynamics.

2011-01-01

262

String thermal tachyons as multiparticle instabilities

Stability of Few-Charge Systems in Quantum Mechanics

The bosonic string on R"2"5xS"1 has a series of states turning tachyonic at radii implying T=IT_H. We employ the B picture to examine these thermal states in the one-loop free energy and find them in various combinations, factorizing towards rational points on the real line boundary of the fundamental domain B: (-1/2=# 0). These thermal tachyons are interpreted as signaling Hagedorn instabilities against the production of an l-highly-excited-identical-strings state, which gives a relation between the one-loop partition function and l-point functions. (orig.).

263

Shedding light on insight: Priming bright ideas

We consider non-relativistic systems in quantum mechanics interacting through the Coulomb potential, and discuss the existence of bound states which are stable against spontaneous dissociation into smaller atoms or ions. We review the studies that have been made of specific mass configurations and also the properties of the domain of stability in the space of masses or inverse masses. These rigorous results are supplemented by numerical investigations using accurate variational methods. A section is devoted to systems of three arbitrary charges and another to molecules in a world with two space-dimensions.

2004-01-01

264

British Library Electronic Table of Contents (United Kingdom)

Previous research has characterized insight as the product of internal processes, and has thus investigated the cognitive and motivational processes that immediately precede it. In this research, however, we investigate whether insight can be catalyzed by a cultural artifact, an external object imbued with learned meaning. Specifically, we exposed participants to an illuminating lightbulb - an iconic image of insight - prior to or during insight problem-solving. Across four studies, exposing participants to an illuminating lightbulb primed concepts associated with achieving an insight, and enhanced insight problem-solving in three different domains (spatial, verbal, and mathematical), but did not enhance general (non-insight) problem-solving.

2010-01-01

265

Search Efficiency in Indexing Structures for Similarity Searching

Reflection of electromagnetic waves by a nonuniform plasma layer covering a metal surface

Similarity searching finds application in a wide variety of domains including multilingual databases, computational biology, pattern recognition and text retrieval. Similarity is measured in terms of a distance function edit distance in general metric spaces, which is expensive to compute. Indexing techniques can be used reduce the number of distance computations. We present an analysis of various existing similarity indexing structures for the same. The performance obtained using the index structures studied was found to be unsatisfactory . We propose an indexing technique that combines the features of clustering with M tree(MTB) and the results indicate that this gives better performance.

2004-01-01

266

RBS Characterization of Yttrium Iron Garnet Thin Films

Reflection coefficients of electromagnetic waves in a nonuniform plasma layer with electrons, positive ions and negative ions, covering a metal surface are investigated by using the finite-difference-time-domain method. It is shown that the reflection coefficients are influenced greatly by the density gradient on the layer edge, layer thickness and electron proportion, i.e., the effect of the negative ions. It is also found that low reflection or high attenuation can be reached by properly choosing high electron proportion, thick plasma layer, and smooth density gradient in the low frequency regime, but sharp density gradient in the high frequency regime. (authors)

2008-07-01

267

Prospective application of advanced series compensation to improve transmission system performance

Magnetic materials such as yttrium iron garnet (YIG) are of great importance for its magneto-optic properties and for their potential applications in the domain of optical telecommunications. The deposition of thin films of YIG, on quartz or GGG (gadolinium gallium garnet) substrate, was performed using radio frequency non reactive magnetron sputtering, followed by high temperature annealing which is needed to enhance the crystallinity of the layers. Rutherford backscattering spectrometry RBS was used to determine the thickness and stoichiometry of the performed layers in order to investigate correlations between growth conditions and the quality of the final material. RBS measurements showed the influence of the deposition time and the temperature substrate on the film growth and its stoichiometry. (author)

2008-12-13

268

Preparation of PbTiO3 nanoceramics based on hydrothermal nanopowders and characterization of their electrical properties

This paper describes the main aspects and results of the planning studies undertaken to evaluate the technical benefits of using Thyristor Controlled Series Compensation (TCSC), in a large 500 kV transmission system (Brazilian North-Northeast system). TCSC controllers design and simplified models for digital non-linear time domain simulations are discussed. The proposed controllers are tuned and used to support the comparative analysis between controlled and fixed series compensation. The relevant conclusions concerning this comparison are highlighted. (author) 2 refs., 14 figs., 3 tabs.

1994-12-31

269

British Library Electronic Table of Contents (United Kingdom)

In this work, we report the preparation of lead titanate (PT) nanoceramics (with an average grain size of ~200nm in diameter) by using hydrothermal PT nanoparticles as start materials and characterized the dielectric and ferroelectric properties. The dielectric constant of the ceramic was found to be ~180 (at 1kHz) at room temperature and reached a maximum value of 8330 at ~490^oC, suggesting that the Curie temperature of the nanoceramics is consistent with the known value of PT crystals. Ferroelectric domains and hysteresis loops were obtained through piezoelectric force microscopy measurements, which provide direct and clear evidence for the ferroelectricity in the nanoceramic samples.

2010-01-01

270

Pre-stack reverse-time migration for elastic waves with application to synthetic offset vertical seismic profiles

Possibility of internal transport barrier formation and electric field bifurcation in LHD plasma

A pre-stack migration algorithm for elastic waves in two-dimensional variable-velocity media is developed, implemented, and tested. The algorithm operates in the time-space domain and is based on reverse-time finite-difference extrapolation of elastic waves. The algorithm is explained and demonstrated in the context of imaging of elastic vertical seismic profile data, but is applicable to any source-recorder geometry. Synthetic test examples include a point diffractor, laterally homogeneous layers, and the flank of a salt dome.

1986-03-01

271

Photoluminescence of manganese- and copper-doped CdS nanowires

Theoretical analysis of the electric field bifurcation is made for the LHD plasma. For given shapes of plasma profiles, a region of bifurcation is obtained in a space of the plasma parameters. In this region of plasma parameters, the electric field domain interface is predicted to appear in the plasma column. The reduction of turbulent transport is expected to occur in the vicinity of the interface, inducing a internal transport barrier. Within this simple model, the plasma with internal barriers is predicted to be realized for the parameters of T{sub e}(0) {approx} 2 keV and n(0) {approx_equal} 10{sup 18} m{sup -3}. (author)

1999-05-01

272

Photoluminescence of manganese- and copper-doped CdS nanowires

Arrays of CdS:Mn{sup 2+}:Cu{sup +} micro- and nanowires grown in polycarbonate ion-track templates exhibit photoluminescence in the spectral domain ranging from 500 to 800 nm at room temperature. A comparison with similar CdS and CdS:Mn{sup 2+} wire arrays is presented. The individual contributions to the emission spectra of Cu{sup +} and Mn{sup 2+} ions in the CdS matrix are explained using their energy level schemes. Also SEM, EDX and EPR data are given for these wires. (copyright 2005 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim) (orig.)

2005-02-01

273

Paul Scherrer Institute Scientific Report 2000. Volume IV: Nuclear Energy and Safety

Arrays of CdS:Mn"2"+:Cu"+ micro- and nanowires grown in polycarbonate ion-track templates exhibit photoluminescence in the spectral domain ranging from 500 to 800 nm at room temperature. A comparison with similar CdS and CdS:Mn"2"+ wire arrays is presented. The individual contributions to the emission spectra of Cu"+ and Mn"2"+ ions in the CdS matrix are explained using their energy level schemes. Also SEM, EDX and EPR data are given for these wires. (copyright 2005 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim) (orig.)

2005-02-01

274

On the 2D Cahn-Hilliard equation with inertial term

Nuclear energy related research in Switzerland is concentrated at PSI's Nuclear Energy and Safety Research Department (NES). The activities of the department are concentrated on three main domains of: Safety and related problems of operating plants; safety features of future reactor and fuel cycles; waste management. Comprehensive assessments of energy systems are carried out in cooperation with PSI's General Energy Research Department. Many of the programs are part of collaborations with universities, industry, or international organisations. Progress in 2000 in these topical areas is described in this report. A list of scientific publications in 2000 is also provided.

2001-03-01

275

On Phase Transition of Compressed Sensing in the Complex Domain

P. Galenko et al. proposed a modified Cahn-Hilliard equation to model rapid spinodal decomposition in non-equilibrium phase separation processes. This equation contains an inertial term which causes the loss of any regularizing effect on the solutions. Here we consider an initial and boundary value problem for this equation in a two-dimensional bounded domain. We prove a number of results related to well-posedness and large time behavior of solutions. In particular, we analyze the existence of bounded absorbing sets in two different phase spaces and, correspondingly, we establish the existence of the global attractor. We also demonstrate the existence of an exponential attractor.

2008-01-01

276

Numerical methods for solving problems with a free boundary. Chislennye metody resheniia zadach so svobodnoi granitsei

The phase transition is a performance measure of the sparsity-undersampling tradeoff in compressed sensing (CS). This letter reports, for the first time, the existence of an exact phase transition for the $\\ell_1$ minimization approach to the complex valued CS problem. This discovery is not only a complementary result to the known phase transition of the real valued CS but also shows considerable superiority of the phase transition of complex valued CS over that of the real valued CS. The results are obtained by extending the recently developed ONE-L1 algorithms to complex valued CS and applying their optimal and iterative solutions to empirically evaluate the phase transition.

2011-01-01

277

Noninvariance of space/time-scale ranges under a Lorentz transformation and the implications for the study of relativistic interactions

Approximate methods are presented for solving nonlinear boundary value problems with an unknown (free) boundary, such as the Stefan problem in heat conductivity. Examples of this kind of problems in thermal physics, hydrodynamics, elasticity, and plasma physics are examined. Attention is given to the principal computational methods for solving stationary problems for second- and fourth-order elliptic equations, such as the domain transformation and penalty methods. To illustrate the capabilities of the methods presented here, examples of numerical solutions are presented for various specific applied problems. 255 references.

1987-01-01

278

New developments in the surveillance and diagnostics technology for vibration, structure-borne sound and leakage monitoring systems

The summary of this report is: (1) The range of scales #LAMBDA# of a system is not a Lorentz invariant and can vary greatly for some systems. (2) There exists an optimum frame which minimizes #LAMBDA#. (3) We demonstrated speedup of x1000 for PIC simulation of relativistic beam interacting with electron background. (4) It is not in contradiction with the conventional scientific wisdom that 'complexity' is an invariant. (5) We identified three domains of application (laser-plasma acceleration, e-cloud in HEP accelerators, free electron lasers) for which speedup ranging from 2 to 4 orders of magnitude were demonstrated on toy problems.

279

Modified spontaneous emission rate in three-dimensional layer-by-layer photonic crystals with planar defects

Monitoring and diagnostic systems are of main importance for a safe and efficient operation of nuclear power plants. The author describes new developments with respect to vibration monitoring with a functional extension in the time domain for den secondary circuit, the development of a local system for the surveillance of rotating machines, the structure-borne sound monitoring with improvement of event analysis, esp. the loose part locating, leakage monitoring with a complete system for humidity measurement, and the development of a common platform for all monitoring and diagnostic systems, that allows an efficient access for comparison and cross references.

280

Inter-ministerial mission against the greenhouse effect; Mission interministerielle contre l'effet de serre

A finite three-dimensional layer-by-layer photonic crystal with planar defects in a layer is shown to drastically modify the spontaneous emission rate of an embedded dipole. Finite-difference time-domain calculations with one quarter symmetric boundary condition and perfectly matched layer demonstrate the strong enhancement effects induced by the cavity resonance of defect modes and band-edge resonant modes. Simulation shows that the emission spectra are quite different when the position or polarization of the dipole is changed. Moreover, the extraction efficiency is calculated to observe the percentage of light leakage through a substrate.

2010-01-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

281

In the framework of the negotiations on the climatic changes, beginning at Rio in 1992, the France received an UN conference from the 4 to 15 of september 2000. This conference determined the necessary actions for the Kyoto protocol validation. This document presents in two part the program of these days. The first part is devoted to the world government policy and the second part defines the french actions decided to fight against the climatic change. A glossary of the main terms adapted to the climatic change domain, is also provided. (A.L.B.)

2000-07-01

282

Inspire

Immersions of Einstein-Riemann spacetimes in six-dimensional flat spaces

Inspire is the project name of a new High Energy Physics information system which will integrate present databases and repositories to host the entire corpus of the HEP literature and become the reference HEP scientific information platform worldwide. It is a common project between CERN, DESY, FERMILAB and SLAC. It will empower scientists with new tools to discover and access the results most relevant to their research; enable novel text- and data-mining applications; deploy new metrics to assess the impact of articles and authors. In addition, it will introduce the Web2.0 paradigm of user-enriched content in the domain of sciences with community-based approaches to the peer-review process.

2008-01-01

283

Hot workability, microstructural control and rate-controlling mechanisms in cast-homogenized AZ31 magnesium alloy

Each choice of an arbitrary nonzero function f of the four immersion parameters is shown to determine 16N[f] distinguishable classes of two-parameter families of immersions of Einstein-Riemann spacetimes in six-dimensional flat spaces, where N[f] is the number of regular immersion parameter domains. The metric tensors, curvature tensors and the immersion loci are calculated in a closed form, and these calculations involve only finitely many algebraic operations. The presence of the arbitrary function provides the opportunity for study of the behaviour of multiple isolated singularities and/or 'shape' functions in general relativity.

2002-09-21

284

Health effects[1997 Scientific Report of the Belgian Nuclear Research Centre

Optimum conditions for microstructural control in industrial hot working of cast and homogenized AZ31 magnesium alloys are evaluated by using a processing map. The recommended window for bulk metal working of this alloy is the domain in the temperature range 300-450 C and strain rate range 1-10 s{sup -1}, and the optimum processing parameters are 400 C and 10 s{sup -1}, where grain-boundary self diffusion is the rate-controlling mechanism. (Abstract Copyright [2009], Wiley Periodicals, Inc.)

2009-03-15

285

Electromagnetic coupling of high-altitude, nuclear electromagnetic pulses

The objectives of the research in the field of epidemiology , performed at the Belgian Nuclear Research Centre SCK-CEN are (1) to study cancer mortality and morbidity in nuclear workers in Belgium; (2) to document the feasibility of retrospective cohort studies in Belgium; (3) to participate in the IARC study. For radiobiology, the main objectives are: (1) to elucidate the mechanisms of the effects of ionizing radiation on the mammalian embryo during the early phase of its development, (2) to assess the genetic risks of maternal exposure to ionizing radiation, (3) to elucidate the mechanisms by which damage to the brain and mental retardation are caused in man after prenatal irradiation. The main achievements in these domains for 1997 are presented.

1998-07-01

286

Discrete simulation of power law noise

We have used scale models to measure the predicted coupling of electromagnetic fields simulating the effects of high-altitude nuclear electromagnetic pulses (HEMP) on the interior surfaces of electronic components. Predictive tools for exterior coupling are adequate. For interior coupling, however, such tools are in their infancy. Our methodological approach combines analytical, computational, and laboratory techniques in a complementary way to take advantage of their separate strengths. Computer models are a promising tool, as they can be used to treat complex objects with arbitrary shapes, dielectrics, and cables, and multiple apertures. Laboratory tests can expand the domain of investigation even further.

1984-11-01

287

Damage characteristics of time domain histories

A method for simulating power law noise in clocks and oscillators is presented based on modification of the spectrum of white phase noise, then Fourier transforming to the time domain. Symmetric real matrices are introduced whose traces--the sums of their eigenvalues--are equal to the Allan variances, in overlapping or non-overlapping forms, as well as for the corresponding forms of the modified Allan variance. Diagonalization of these matrices leads to expressions for the probability distributions for observing a variance at an arbitrary value of the sampling or averaging interval $\\tau$, and hence for estimating confidence in the measurements. A number of applications are presented for the common power-law noises.

2011-01-01

288

Competencies of Employment Specialists for Effective Job Development

It is possible to create nomographs similar to Fig. 2.10 to characterise damage potential of candidate time histories, provided there exists extensive records of earlier time-histories and the damage that they have caused. Thus in order to create such nomographs, one needs the correlated documentation between the input to the structure and the resulting damage. In order to use the Response-Spectra approach, one needs good statistical description of the input to the system. Extensive literature exists on both these methods. The MAC method that has being developed for the present research has yet to be validated. However, if it is successful, it would provide a valuable link between the SEA method and the rational method.

1989-11-01

289

British Library Electronic Table of Contents (United Kingdom)

A scant body of literature addresses competencies needed for successful job development. This study aimed to identify competencies needed for this role. In this analysis, we observed employment specialists identified as successful in helping consumers obtain employment perform job development duties. We supplemented observations with interviews. Employment specialists possessed competencies in six domains: time management, advocacy, building partnerships with consumers, working as part of a team, face-to-face communication, and networking. The conceptual framework derived from this study can inform supported employment supervisors and researchers about the competencies that can strengthen supported employment teams.

2011-01-01

290

Building ventilation, state of the art, prospective; Ventilation des batiments etat des lieux, prospective

Bidimensional instability in antiferroelectric liquid crystals

This conference is composed of 21 communications and 21 posters in the domain of building ventilation and indoor air quality; the main themes are: indoor air quality assessment and optimization; performance enhancement and optimization of ventilation systems and equipment; ventilation systems for renovated and rehabilitated buildings; French and European regulations, standardizations and certifications; experimental and numerical simulation studies concerning ventilation systems, air flow, temperature distribution, air quality, thermal comfort and ventilation-induced acoustic levels

1995-10-01

291

Scientific Electronic Library Online (English)

Abstract in english In the last decade it has been experimentally found a periodic domain pattern arising in smectic C* liquid crystals in surface stabilized bookshelf geometry. Such a periodic texture appears after switching-off an external electric field, even in strong anchoring conditions. It has a static character and can be bidimensional, being dependent on both directions normal to the smectic planes and normal to the cell plates. In the present work an explanation to this phenomenon (more) is proposed. According to our model in the antiferroelectric phase the biperiodic texture is a threshold phenomenon, appearing for values of the spontaneous polarization greater than a critical value, whereas in the ferroelectric phase this type of bidimensional instability is hindered.

2002-06-01

292

Automatic Control via Thermostats of a Hyperbolic Stefan Problem with Memory

Application of the combined integral method to Stefan problems

A hyperbolic Stefan problem based on the linearized Gurtin-Pipkin heat conduction law is considered. The temperature and free boundary are controlled by a thermostat acting on the boundary. This feedback control is based on temperature measurements performed by real thermal sensors located within the domain containing the two-phase system and/or at its boundary. Three different types of thermostats are analyzed: simple switch, relay switch, and a Preisach hysteresis operator. The resulting models lead to integrodifferential hyperbolic Stefan problems with nonlinear and nonlocal boundary conditions. Existence results are proved in all the cases. Uniqueness is also shown, except in the situation corresponding to the ideal switch.

1999-03-15

293

British Library Electronic Table of Contents (United Kingdom)

In this paper we present a new, accurate form of the heat balance integral method, termed the combined integral method (CIM). The application of this method to Stefan problems is discussed. For simple test cases the results are compared with exact and asymptotic limits. In particular, it is shown that the CIM is more accurate than the second order, large Stefan number, perturbation solution for a wide range of Stefan numbers. In the initial examples it is shown that the CIM reduces the standard problem, consisting of a PDE defined over a domain specified by an ODE, to the solution of one or two algebraic equations. The latter examples, where the boundary temperature varies with time, reduce to a set of three first order ODEs.

2011-01-01

294

Application of power system stabilizer at Bandar-Abbas power station

Analyzing Morphology and Thermal History of Polybutylene Terephthalate by THz Time-domain Spectroscopy

System instability as result of high power generation of one of the largest plants of the Iranian electric power grid prevented the plant to be fully utilized. PSSs were installed on the generating units of the power station, to improve its small signal stability, and enhance the stable generation limit. Domain separation and pole assignment techniques were applied for the PSS design. Several field tests were also carried out to verify its effectiveness. This paper presents the PSS tuning procedure, including the design criteria and some of the field test results.

1994-08-01

295

British Library Electronic Table of Contents (United Kingdom)

We have measured the frequency-dependent dielectric function of semi-crystalline polybutylene terephthalate (PBT) in the terahertz region between 100?GHz and approximately 2.8?THz. A characteristic band is observed around 2.38?THz. The intensity of this band is a good indicator of the degree of crystallinity of the different samples. A potential assignment of this band is proposed, based on the comparison with spectroscopic data of the structurally very similar polyethylene terephtalate (PET). Furthermore, the frequency-dependent index of refraction of PBT reveals more insight about the morphology and different thermal history of the samples under investigation.

2011-01-01

296

Algorithmic tangent stiffness in elastoplasticity and elastoviscoplasticity: A geometric insight

British Library Electronic Table of Contents (United Kingdom)

The algorithmic, or consistent, tangent stiffness was introduced to improve the asymptotic convergence rate of the iterative correction algorithm for the evolutive analysis of elastoplastic structures. The original approach is based on a formulation of the elastoplastic law in terms of a plastic multiplier with an analysis which, in general, requires an operator inversion. A geometric description of the method, based on hypersurface theory, is proposed here to provide a clear picture of the algorithmic properties. An estimate of the tangent stiffness associated with finite step elastoplastic and elastoviscoplastic constitutive models is given. It is based on the properties of the projection operator on the elastic domain and avoids operator inversions retaining the beneficial properties of...

2010-01-01

297

The p75"N"T"R tumor suppressor induces cell cycle arrest facilitating caspase mediated apoptosis in prostate tumor cells

The C'-terminal interaction domain of the thyroid hormone receptor confers the ability of the DNA site to dictate positive or negative transcriptional activity

The p75 neurotrophin receptor (p75"N"T"R) is a death receptor which belongs to the tumor necrosis factor receptor super-family of membrane proteins. This study shows that p75"N"T"R retarded cell cycle progression by induced accumulation of cells in G0/G1 and a reduction in the S phase of the cell cycle. The rescue of tumor cells from cell cycle progression by a death domain deleted (#DELTA#DD) dominant-negative antagonist of p75"N"T"R showed that the death domain transduced anti-proliferative activity in a ligand-independent manner. Conversely, addition of NGF ligand rescued retardation of cell cycle progression with commensurate changes in components of the cyclin/cdk holoenzyme complex. In the absence of ligand, p75"N"T"R-dependent cell cycle arrest facilitated an increase in apoptotic nuclear fragmentation of the prostate cancer cells. Apoptosis of p75"N"T"R expressing cells occurred via the intrinsic mitochondrial pathway leading to a ...

2006-03-24

298

Single protein omission reconstitution studies of tetracycline binding to the 30S subunit of Escherichia coli ribosomes

To investigate mechanisms responsible for positive and negative transcriptional control, the authors have utilized two types of promoters that are diffferentially regulated by thyroid hormone (T{sub 3}) receptors. Promoters containing the palindromic T{sub 3} response element TCAGGTCA TGACCTGA are positively regulated by the T{sub 3} receptor after the administration of T{sub 3}, whereas otherwise identical promoters containing the estrogen response element TCAGGTCA CTG TGACCTGA can be regulated negatively; converse effects are observed with the estrogen receptor. They describe evidence that the transcriptional inhibitory effects of the T{sub 3} or estrogen receptors on the estrogen or T{sub 3} response elements, respectively, are imposed by amino acid sequences in the C'-terminal region that colocalize with dimerization and hormone-binding domains and that these sequences can transfer inhibitory functions to other classes of transcription factors. Removal ...

1990-10-01

299

Missense mutations in the growth hormone receptor dimerization region in Laron syndrome

In previous work the authors showed that on photolysis of Escherichia coli ribosomes in the presence of ({sup 3}H)tetracycline (TC) the major protein labeled is S7, and they presented strong evidence that such labeling takes place from a high-affinity site related to the inhibitory action of TC. In this work they use single protein omission reconstitution (SPORE) experiments to identify those proteins that are important for high-affinity TC binding to the 30S subunit, as measured by both cosedimentation and filter binding assays. With respect to both sedimentation coefficients and relative Phe-tRNA{sup Phe} binding, the properties of the SPORE particles they obtain parallel very closely those measured earlier, with the exception of the SPORE particle lacking S13. A total of five proteins, S3, S7, S8, S14, and S19, are shown to be important for TC binding, with the largest effects seen on omission of proteins S7 and S14. Determination of the protein compositions of the corresponding ...

1990-06-05

300

Kinetic, spectroscopic and chemical modification study of iron release from transferrin; iron(III) complexation to adenosine triphosphate

Laron syndrome (LS) is an autosomal recessively inherited condition characterized by insensitivity to endogenous and exogenous GH. Affected individuals have severe episodes and other characteristic features. GH receptor gene mutations are present in all affected individuals in whom molecular studies have been reported. The GH receptor is a plasma membrane-spanning protein in which the extracellular domain binds circulating GH and the intracellular domain interacts with the JAK-2 kinase and possibly other intracellular signaling molecules. GH receptor dimerization occurs on GH binding and is thought to be required for normal signal transduction. We have studied the GH receptor genes of four unrelated individuals affected with LS from the United States, Italy, Saudi Arabia, and India. We have identified four different missense mutations that alter consecutive amino acids 152 to 155 in or near the dimerization domain of the GH ...

1994-09-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

301

Effect of electron irradiation on domain wall pinning defects in 50-50 NiFe

Amino acids other than those that serve as ligands have been found to influence the chemical properties of transferrin iron. The catalytic ability of pyrophosphate to mediate transferrin iron release to a terminal acceptor is largely quenched by modification non-liganded histine groups on the protein. The first order rate constants of iron release for several partially histidine modified protein samples were measured. A statistical method was employed to establish that one non-liganded histidine per metal binding domain was responsible for the reduction in rate constant. These results imply that the iron mediated chelator, pyrophosphate, binds directly to a histidine residue on the protein during the iron release process. EPR spectroscopic results are consistent with this interpretation. Kinetic and amino acid sequence studies of ovotransferrin and lactoferrin, in addition to human serum transferrin, have allowed the tentative assignment of His-207 in the ...

1985-01-01

302

Dynamic-stiffness matrix of embedded and pile foundations by indirect boundary-element method

A magnetic measuring technique, which sorts out defects according to a distribution function n, was used to study the influence of electron irradiation on 50-50 NiFe. The distribution function is determined in terms of the maximum force f/subm/ that a defect can exert on a forward moving domain wall, or equivalently, the range z_0, which is the distance the mean position of the wall may move past the defect before the wall snaps free from the pinning action of the defect. The range and maximum force are related by a spring constant k, viz., f/subm/=kz_0. The quantity n (z_0) dz_0 gives the number of defects per unit volume having a range between z_0 and z_0+dz_0. Distribution functions were determined before and after electron irradiation. The irradiation was for 100 min with 18-MeV electrons with a dose of 1.1times10"1"7 e/cm"2. Following irradiation, there was a substantial decrease in the number of short-range defects (i.e., defects capable of pinning a ...

303

Development of Intelligent Setting System for Fracture Based on X-Ray Image

The boundary-integral equation method is well suited for the calculation of the dynamic-stiffness matrix of foundations embedded in a layered visco-elastic halfspace (or a transmitting boundary of arbitrary shape), which represents an unbounded domain. It also allows pile groups to be analyzed, taking pile-soil-pile interaction into account. The discretization of this boundary-element method is restricted to the structure-soil interface. All trial functions satisfy exactly the field equations and the radiation condition at infinity. In the indirect boundary-element method distributed source loads of initially unknown intensities act on a source line located in the excavated part of the soil and are determined such that the prescribed boundary conditions on the structure-soil interface are satisfied in an average sense. In the two-dimensional case the variables are expanded in a Fourier integral in the wave number domain, while in three ...

1984-08-01

304

Assignment of the human aggrecan gene (AGC1) to 15q26 using fluorescence in situ hybridization analysis

In order to achieve micro-wound, intelligence and high efficiency for fracture setting, intelligent setting system for fracture is proposed in accordance with biomechanics and fracture therapy theory. In the comprehensive medical system based on C-shape-arm X-machine, image processing and analysis is the core, programmable logical controller and stepping motor are important driving parts controlling mechanical parts. Six degree of freedom dynamics sensor ensures to control accurately force and moment. On the foundation of analyzing X-ray image peculiarities, method of processing and analysis is put forward, combining time domain with frequency domain. After mining domain knowledge in depth, setting actions is quantized into three non-continuous steps and is parameterized into two angles and one distance aiming at femoral-neck fracture. Objective features are extracted by virtue of three power polymerization curved surface ...

2006-10-15

305

CuPt-type ordering of MOCVD In{sub 0.49}Al{sub 0.51}P.

The large aggregating proteoglycan aggrecan is a major structural component of the extracellular matrix of articular cartilage. Recent cDNA cloning of the human aggrecan gene (AGC1) reveals a core protein of at least 2316 amino acids characterized by several distinct structural domains. Two globular domains, termed G1 and G2, are present at the amino terminus of the molecule and a third, termed G3, is present at the carboxy terminus. The G1 domain is homologous in structure to the cartilage link protein and accounts for the aggregating potential of aggrecan through its ability to interact with hyaluronic acid. The aggrecan gene is known to consist of 15 exons, with each exon encoding a distinct functional region of the mature protein. However, while the link protein gene is known to reside on chromosome 5 in the human, the location of the aggrecan gene is currently undetermined in any species. The probe (pAGG2) for the ...

1993-05-01

306

Wind turbine fault diagnosis based on Morlet wavelet transformation and Wigner-Ville distribution

CuPt-type ordering in In{sub 0.49}Al{sub 0.51}P is studied by TEM. The lattice-matched film was grown by MOCVD on a GaAs substrate oriented 10{sup o} off (001) towards [110], at 650 C and 25 nm/min. TEM [110] and [1{bar 1}0] cross-sections (XS) were made by wedge polishing and 2 kV Ar ion milling. In CuPt-type ordering of In{sub 0.52}Ga{sub 0.48}P, alternating In-Ga-In-Ga {l_brace}111{r_brace} planes of group III atoms produce 1/2 {bar 1}11 and 1/2 1{bar 1}1 order spots in the 110 SADP, while the [1{bar 1}0] SADP shows no order spots [1-3]. A few studies have reported this type of order in In{sub 0.49}Al{sub 0.51}P [4]. The 004 BF image of the [1{bar 1}0] XS in Fig. 1 shows uneven light/dark contrast modulation due to phase separation often observed in In{sub 0.52}Ga{sub 0.48}P. There are also light/dark layers marked ML parallel to the film growth plane; such unintentional multilayers have also been observed [5] but their origin is not understood. Order lamellae {approx}1.5 nm thick ...

2002-03-14

307

British Library Electronic Table of Contents (United Kingdom)

Based on the Morlet wavelet transformation and Wigner-Ville distribution (WVD), we present a wind turbine fault diagnosis method in this paper. Wind turbine can be damaged by moisture absorption, fatigue, wind gusts or lightening strikes. Due to this reason, there is an increasing need to monitor the health of these structures. Vibration analysis is the best-known technology applied in wind turbine condition monitoring, in which the time-frequency analysis techniques such as Wigner-Ville distribution (WVD) are widely used. Theoretically WVD has an infinite resolution in time-frequency domain. For early wind turbine fault signals, however, there are two main difficulties in WVD analysis. One is strong noise signals in the background and the other is cross terms in WVD itself. In this paper,...

2010-01-01

308

Weighted shifts on directed trees

Ultrafast resonance energy transfer in bio-molecular systems

A new class of (not necessarily bounded) operators related to (mainly infinite) directed trees is introduced and investigated. Operators in question are to be considered as a generalization of classical weighted shifts, on the one hand, and of weighted adjacency operators, on the other; they are called weighted shifts on directed trees. The basic properties of such operators, including closedness, adjoints, polar decomposition and moduli are studied. Circularity and the Fredholmness of weighted shifts on directed trees are discussed. The relationships between domains of a weighted shift on a directed tree and its adjoint are described. Hyponormality, cohyponormality, subnormality and complete hyperexpansivity of such operators are entirely characterized in terms of their weights. Related questions that arose during the study of the topic are solved as well. Particular trees with one branching vertex are intensively studied mostly in the context of subnormality and ...

2009-01-01

309

British Library Electronic Table of Contents (United Kingdom)

In this article, we present our consistent efforts to explore the dynamical pathways of the migration of electronic radiation by using ultrafast (picosecond/femtosecond time scales) F?rster resonance energy transfer (FRET) technique. The ultrafast non-radiative energy migration from an intrinsic donor fluorophore (Tryptophan, Trp214) present in domain IIA of a transporter protein human serum albumin (HSA) to various non-covalently/covalently attached organic/inorganic chromophores including photoporphyrin IX (PPIX), polyoxovanadate [V15As6O42(H2O)]-6 clusters (denoted as V15) and CdS quantum dots (QDs) has been explored. We have also used other covalently/non-covalently attached extrinsic fluorogenic donors (NPA, ANS) in order to exploit the dynamics of resonance energy migration of an enz...

2010-01-01

310

Traditional Medicine Collection Tracking System (TM-CTS): A database for ethnobotanically driven drug-discovery programs

British Library Electronic Table of Contents (United Kingdom)

Ethnopharmacological relevance: Ethnobotanically driven drug-discovery programs include data related to many aspects of the preparation of botanical medicines, from initial plant collection to chemical extraction and fractionation. The Traditional Medicine Collection Tracking System (TM-CTS) was created to organize and store data of this type for an international collaborative project involving the systematic evaluation of commonly used Traditional Chinese Medicinal plants. Materials and methods: The system was developed using domain-driven design techniques, and is implemented using Java, Hibernate, PostgreSQL, Business Intelligence and Reporting Tools (BIRT), and Apache Tomcat. Results: The TM-CTS relational database schema contains over 70 data types, comprising over 500 data fields. Th...

2011-01-01

311

Topological Analysis of Large-scale Biomedical Terminology Structures

British Library Electronic Table of Contents (United Kingdom)

ObjectiveTo characterize global structural features of large-scale biomedical terminologies using currently emerging statistical approaches.DesignGiven rapid growth of terminologies, this research was designed to address scalability. We selected 16 terminologies covering a variety of domains from the UMLS Metathesaurus, a collection of terminological systems. Each was modeled as a network in which nodes were atomic concepts and links were relationships asserted by the source vocabulary. For comparison against each terminology we created three random networks of equivalent size and density.MeasurementsAverage node degree, node degree distribution, clustering coefficient, average path length.ResultsEight of 16 terminologies exhibited the small-world characteristics of a short average path le...

2007-01-01

312

Time-resolved triple-axis spectroscopy - a new method for real-time neutron scattering

The international management of big scientific research programs. The example of particle physics; La gestion internationale des grands programmes de recherche scientifique l'exemple de la physique des particules

A new method for kinetic experiments with neutrons is described. This method combines the conventional triple-axis neutron spectroscopy with relaxation-type experiments. Whereas the former method yields information about the microscopic dynamics of solids, the latter provides macroscopic relaxation times. The combination of both methods allows to determine the microscopic mechanism of relaxation processes. The time-resolved triple-axis spectroscopy is limited to reversible processes and to time scales from 10"-"3 to 10"4 s. Typical applications are the kinetics of phase transformations (structural and dynamical changes), kinetics of domain distributions, kinetics of (spinodal) decomposition, reversible solid state reactions, time-dependent occupation of phonon states or phonon lifetimes. (orig.).

1990-04-01

313

The forward modeling and reverse time migration of seismic wave field in complex medium

High energy physics is a basic research domain with a well established European and international cooperation. Cooperation can be of different type depending on the size of the facilities involved (accelerators), on their financing, and on the type of experiments that use these facilities. The CERN, the European center for nuclear research, created in October 1954, is the best example of such a cooperation. This article examines first the juridical and scientifical structure of the CERN and the mode of organization of big experiments. Then, it presents the role of international committees in the establishment of a common scientific policy in Europe and in the rest of the world. Finally, the possible future evolution of the CERN towards a worldwide project is evoked. (J.S.)

2004-07-01

314

The N-terminal domain of a-dystroglycan, released as a 38kDa protein, is increased in cerebrospinal fluid in patients with Lyme neuroborreliosis

The space derivation term of a wave equation is accurately calculated using Fourier transform method, and the wave equation only relating to time derivative in time-space domain is derived. Solving this equation with the aid of central difference method brings the numerical recursion formula for forward modeling or reverse time migration of seismic wave field in the medium in which seismic velocity varies. The key to this method lies in introducing two auxiliary wave fields relating to velocity and spacial frequency of Fourier transform respectively after multi-dimensional Fourier transform respectively after multi-dimensional Fourier transform of space vector is made. Theoretically, this method is suitable to the forward modeling and migration of seismic wave field in complex area where seismic velocity and structure shape vary arbitrarily. Theoretical results proved this method satisfactory.

1988-01-01

315

British Library Electronic Table of Contents (United Kingdom)

a-Dystroglycan is an extracellular adhesion protein that is known to interact with different ligands. The interaction is thought to stabilize the integrity of the plasma membrane. The N-terminal part of a-dystroglycan may be proteolytically processed to generate a small 38kDa protein (a-DG-N). The physiological significance of a-DG-N is unclear but has been suggested to be involved in nerve regeneration and myelination and to function as a potential biomarker for neurodegenerative and neuromuscular diseases. In this report we show that a-DG-N is released into different body fluids, such as lachrimal fluid, cerebrospinal fluid (CSF), urine and plasma. To investigate the significance of a-DG-N in CSF we examined the levels of a-DG-N and known neurodegenerative markers in CSF from patients di...

2011-01-01

316

The Generalized Quantization Schemes for Games and its Application to Quantum Information

The French Electricity Company (EDF) and the environment. Press file for 1996; EDF et l'environnment 1996. Dossier de presse

Theory of quantum games is relatively new to the literature and its applications to various areas of research are being explored. It is a novel interpretation of strategies and decisions in quantum domain. In the earlier work on quantum games considerable attention was given to the resolution of dilemmas present in corresponding classical games. Two separate quantum schemes were presented by Eisert et al. and Marinatto and Weber to resolve dilemmas in Prisoners' Dilemma and Battle of Sexes games respectively. However for the latter scheme it was argued that dilemma was not resolved. We have modified the quantization scheme of Marinatto and Weber to resolve the dilemma. We have developed a generalized quantization scheme for two person non-zero sum games which reduces to the existing schemes under certain conditions. Applications of this generalized quantization scheme to quantum information theory are studied. Measurement being ubiquitous in quantum mechanics can ...

2010-01-01

317

Technical development of equipment for rural electrification resulting from the lessons drawn from the Polynesian programs of the eighties

In 1996 the actions of EDF in the domain of environment have recorded FF 4 billions (FF 3.5 billion in 1995), representing about 2% of the EDF's turnover. The EDF keeps on its efforts for reducing the impact of its activities upon environment. Several applications of an environment protective electricity generation are promoted by the company. The company brings services and technical solutions to its clients which meet their energy needs and conserving at the same time the life conditions. Furthermore, EDF participates in the activity of numerous national and international organisms, intervening in the environmental questions, in decision making, participating in studies and actions and following continually the direction of a durable economic and social development. The report is structured in three chapters: 1. an industrial responsibility; 2. services and techniques for environment; 3. action towards a durable development.

1997-03-27

318

THE EFFECT OF VARIABLE THERMAL CONDUCTIVITY ON MICRO-POLAR FLUID FLOW BY CHEBYSHEV COLLOCATION METHOD

The information gathered as operating manager when implementing the first photovoltaic rural electrification and technology transfer program carried out to date in the world in French Polynesia from 1978 to 1990 are detailed. The technical developments of equipment and the work in progress at the GENEC Cadarache within French, European or IEA programs in order to improve some components or appliances and make up for certain deficiencies are presented. This involves accelerated aging tests, Standardization work, development of high efficiency equipment. Non technical barriers are often emphasized. Technical barriers also exists. Considerable work in many domains of small PV systems remains to be done so as to combine all the conditions required to implement successful large programs in developed as well as in developing countries.

1994-12-31

319

British Library Electronic Table of Contents (United Kingdom)

In this article, the authors analyzed the effect of thermal conductivity on unsteady magnetohydrodynamic (MHD) free convection in a micro-polar fluid past a semi-infinite vertical porous plate. The fluid thermal conductivity is assumed to vary as a linear function of temperature. By using the Chebyshev collocation method in the spatial direction and the Crank-Nicolson method in the time direction, the boundary layer equations are transformed into a linear algebraic system. There are several material parameters whose affect on the flow have been studied, for instance, thermal conductivity, radiation, magnetic, micro-polar, suction (or injection) parameters, and Prandtl number. Boundary layer and Boussineq approximations have been introduced together to describe the flow field. The domain of...

2010-01-01

320

Software systems in-house integration: Architecture, process practices, and strategy selection

British Library Electronic Table of Contents (United Kingdom)

As organizations merge or collaborate closely, an important question is how their existing software assets should be handled. If these previously separate organizations are in the same business domain - they might even have been competitors - it is likely that they have developed similar software systems. To rationalize, these existing software assets should be integrated, in the sense that similar features should be implemented only once. The integration can be achieved in different ways. Success of it involves properly managing challenges such as making as well founded decisions as early as possible, maintaining commitment within the organization, managing the complexities of distributed teams, and synchronizing the integration efforts with concurrent evolution of the existing systems.Th...

2007-01-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

321

Rigorous and General Definition of Thermodynamic Entropy

Resonant frequencies and Q factors of dielectric parallelepipeds by measurement and by FDTD

The physical foundations of a variety of emerging technologies --- ranging from the applications of quantum entanglement in quantum information to the applications of nonequilibrium bulk and interface phenomena in microfluidics, biology, materials science, energy engineering, etc. --- require understanding thermodynamic entropy beyond the equilibrium realm of its traditional definition. This paper presents a rigorous logical scheme that provides a generalized definition of entropy free of the usual unnecessary assumptions which constrain the theory to the equilibrium domain. The scheme is based on carefully worded operative definitions for all the fundamental concepts employed, including those of system, property, state, isolated system, environment, process, separable system, system uncorrelated from its environment, and parameters of a system. The treatment considers also systems with movable internal walls and/or semipermeable walls, with chemical reactions ...

2010-01-01

322

Recent Energy Saving Technologies on Railway Traction Systems

This paper describes the measurement and computation of the resonant frequencies and the associated Q factors of dielectric parallelepipeds made of high-permittivity, low-loss ceramic materials. Each resonance peak is measured separately with a fine frequency step. A curve-fitting method is used to accurately estimate the resonant frequency and 3 dB bandwidth from the somewhat noisy measured data. The finite-difference time-domain method is used to compute the initial portion of the backscattered field due to a Gaussian pulse plane wave. The time response is then extended to zero value by Prony`s method. The measured and computed data is compared for a parallelepiped resonator of permittivity 37.84.

1994-12-31

323

British Library Electronic Table of Contents (United Kingdom)

Energy saving technologies in the railway vehicle traction field can be mainly categorized into two domains: reducing loss and increasing the regenerative energy. Energy saving technologies for the traction equipment by the use of power converters with less loss and high-efficiency permanent magnet synchronous motors are introduced. The regenerative brake related technologies are also presented as another measure to save the energy, including the improvement of the regenerative brake control and application of energy storage devices. It is concluded that the benefit of the energy saving technology is not only the energy saving itself but also downsizing traction equipments and reducing the maintenance work in the electrical railway system. Copyright Copyright 2010 Institute of Electrical E...

2010-01-01

324

Real time automatic discriminating of ultrasonic flaws

Reactive blending of poly(ethylene 2,6-naphthalate) and Vectra A

This paper is concerned with the real time automatic discriminating of flaws from two categories; i. cracks (planar defect) and ii. Non-cracks (volumetric defect such as cluster porosity and slag) using pulse-echo ultrasound. The raw ultrasonic flaws signal were collected from a computerized robotic plane scanning system over the whole of each reflector as the primary source of data. The signal is then filtered and the analysis in both time and frequency domain were executed to obtain the selected feature. The real time feature analysis techniques measured the number of peaks, maximum index, pulse duration, rise time and fall time. The obtained features could be used to distinguish between quantitatively classified flaws by using various tools in artificial intelligence such as neural networks. The proposed algorithm and complete system were implemented in a computer software developed using Microsoft Visual BASIC 6.0 (author)

2009-07-20

325

British Library Electronic Table of Contents (United Kingdom)

In situ composites based on poly(ethylene 2,6-naphthalate) (PEN) and a thermotropic liquid crystal polymer (Vectra A950) were prepared by melt blending under different processing conditions. Thermal behaviour, mechanical and physical properties and morphology of the blends were investigated. The DSC analysis indicates that, as expected, Vectra enhances the crystallization process of PEN. Moreover, mechanical and thermal tests evidence the significant role of 20wt% Vectra on increasing the material performances; tensile properties, coupled with SEM, show that strength and modulus of PEN are significantly improved when Vectra domains are long and continuous fibrils. The overall results can be attributed to the compatibilisation of the system induced by the mixing conditions that affect the e...

2009-01-01

326

Primates do not spontaneously use shape properties for object individuation: a competence or a performance problem?

British Library Electronic Table of Contents (United Kingdom)

Several recent studies have documented that non-human primates can individuate objects according to property and/or kind information in much the same way as human infants do from around one year of age when they begin to acquire language. Some studies suggest, however, that only some properties are used for the individuation of food items: color, but not shape. The present study investigated whether these findings reveal a true competence problem with shape properties in the food domain or whether they merely reveal a performance problem (e.g., lack of attention to shapes). We tested 25 great apes (chimpanzees, bonobos and gorillas) in two food individuation tasks. We manipulated subjects? experience with differences in color and shape properties of food items. Results indicated (i) that a...

2011-01-01

327

Precipitation mechanisms and subsequent hardening kinetics in the #beta#-CEZ alloy

Polarised neutron reflectometry study of Co/CoO exchange-biased multilayers

The #beta#-CEZ alloy : Ti-5%Al-2%Sn-4%Zr-4%Mo-2%Cr-1%Fe is a near #beta# titanium alloy. Since its processing routes include heat treatment (consisting of solution treatment and ageing), it has been decided to study the influence of the #beta# phase stability on #alpha# phase precipitation and hardening kinetics. Small sized specimens, coming from industrial heats, have been heat treated above and below the #beta# transus, and then water quenched. Therefore, several degree of #beta# stability are obtained. When it is increased (i.e. the solution treatment temperature is lowered), #alpha# or #omega# phases precipitations are delayed, as well as the hardening phenomena. Moreover, the #omega# stability domain is reduced. The mechanisms of #alpha# or #omega# precipitation are discussed, and related to the hardening kinetics. (orig.).

328

P03-378 - Erectile dysfunction in psychiatric patients

We have investigated via SQUID magnetometry and polarised neutron reflectivity the exchange-bias effect in CoO/Co sputtered multilayers. In particular, we studied the magnetisation reversal and the time relaxation of the exchange-bias field close to the coercive field H{sub c1}. Neutron intensities of all four cross sections (I++, I+-, I-+, I-) were recorded at the position of the first multilayer Bragg peak while scanning the magnetic field. From such scans we infer that the magnetisation reversal for the ascending as well as for the descending branch of the magnetic hysteresis occurs not by in-plane rotation but through domain-wall movements. The exchange-bias field, H{sub EB}, is strongly affected by thermal fluctuations. H{sub EB} decreases, following an exponential decay function with a half-life time of about 580 s at T=240 K. (orig.)

2002-07-01

329

British Library Electronic Table of Contents (United Kingdom)

Introduction: Erectile dysfunction (ED) is defined as the inability to achieve or maintain an erection sufficient for sexual activity. Objectives: ED is a common condition in psychiatric patients, which can modify their quality of life. Aims: The aim of this study is to assess the prevalence and the severity of ED in psychiatric patients. Methods: This naturalistic, observational study was conducted during a six months period. The International Index of Erectile Function (IIEF) 15-item questionnaire was used to assess 144 male inpatients with different psychiatric disorders. IIEF is a brief, cross-culturally valid, self-administered scale for detecting treatment-related changes in patients with erectile dysfunction and addresses the relevant domains of male sexual function: erectile functi...

2011-01-01

330

On the Reinhardt Conjecture

On strategies for imbalanced text classification using SVM: A comparative study

In 1934, Reinhardt asked for the centrally symmetric convex domain in the plane whose best lattice packing has the lowest density. He conjectured that the unique solution up to an affine transformation is the smoothed octagon (an octagon rounded at corners by arcs of hyperbolas). This article offers a detailed strategy of proof. In particular, we show that the problem is an instance of the classical problem of Bolza in the calculus of variations. A minimizing solution is known to exist. The boundary of every minimizer is a differentiable curve with Lipschitz continuous derivative. If a minimizer is piecewise analytic, then it is a smoothed polygon (a polygon rounded at corners by arcs of hyperbolas). To complete the proof of the Reinhardt conjecture, the assumption of piecewise analyticity must be removed, and the conclusion of smoothed polygon must be strengthened to smoothed octagon.

2011-01-01

331

British Library Electronic Table of Contents (United Kingdom)

Many real-world text classification tasks involve imbalanced training examples. The strategies proposed to address the imbalanced classification (e.g., resampling, instance weighting), however, have not been systematically evaluated in the text domain. In this paper, we conduct a comparative study on the effectiveness of these strategies in the context of imbalanced text classification using Support Vector Machines (SVM) classifier. SVM is the interest in this study for its good classification accuracy reported in many text classification tasks. We propose a taxonomy to organize all proposed strategies following the training and the test phases in text classification tasks. Based on the taxonomy, we survey the methods proposed to address the imbalanced classification. Among them, 10 common...

2009-01-01

332

New anti-jamming technique for GPS and GALILEO receivers using adaptive FADP filter

British Library Electronic Table of Contents (United Kingdom)

Anti-jamming techniques to improve Global Positioning System (GPS) receivers robustness have been mainly developed in military applications. None of civilian techniques can procure sufficient robustness against occasional or intentional jammers for civil GPS or GALILEO navigation receivers. The amplitude domain processing (ADP) filtering is a technique based upon Capon works and Neyman-Pearson theory. Several experiments concerning the ADP filtering have been considered at the 3DETSNAV division of LACIME laboratory at Ecole de technologie superieure (ETS), which have proved that the technique is reliable in order to eradicate powerful interference present in the spread spectrum signal. However, the results show that the ADP filter has a real limitation when submitted to multiple interferen...

2006-01-01

333

Neural network and noise injection for the modeling of ozone pollution; Reseau de neurones et injection de bruit pour la modelisation de la pollution par l'ozone

Naval Sea Systems Command occupational safety and health record-keeping system. Hazardous Materials Control Module. Program maintenance manual

This study has been carried out in the framework of a collaboration between the laboratory of processes automation (LAP, Caen (France)), and Air Com, a monitoring network for the prevention of atmospheric pollution in Basse-Normandie. It aims at obtaining a medium and long term forecast of the ozone level above the Caen city. The expected goal is to foresee the pollution peaks exceeding the warning thresholds, but the rareness of such events make them more difficult to predict. In order to solve this kind of problem, a neural modeling method combined with a noise injection technique has been implemented in order to obtain a sufficiently performing model over the whole domain of operation. (J.S.)

2001-07-01

334

Nano photonic sensors for microdamage detection : an exploratory simulation.

Since August 1984, the MITRE Corporation has been supporting the Naval Sea Systems Command (NAVSEA) and the Naval Medical Command (NAVMEDCOM) in their joint efforts to enhance the Navy Occupational Health Information Management System (NOHIMS). The goal of the enhancement effort was to create a comprehensive occupational health and safety system for Navy industrial facilities by expanding upon the original NOHIMS functions and adding modules for hazard deficiency abatement, hazardous-material control, injury claims and compensation, and safety and health training. To meet this goal, MITRE developed an enhanced industrial subsystem, referred to as the Occupational Safety and Health Record Keeping System (OSHRKS), using a prototyping approach and a public-domain data base-management software package, the Veterans Administration's (VA's) FileManager (FileMan).

1987-06-01

335

Musicians demonstrate experience-dependent brainstem enhancement of musical scale features within continuously gliding pitch

Nano photonic materials are synthetically manufactured crystals at the nano scale with the target of creating a microstructure with a special electro-magnetic periodicity. Such nano photonic materials have the ability to control light propagation and thus are capable of creating photonic bandgaps in the frequency domain. We propose using nano photonic crystals as sensors to detect microdamage in composite materials. We demonstrate using a simulation model that a nano photonic sensor attached to a composite bar experiences a significant change in its bandgap profile when damage is induced in the composite bar. The model predicts the frequency response of the nano photonic sensor using the transfer matrix method. A damage metric to evaluate the change in the frequency response is developed. Successful developments of nano photonic sensors allow damage identification at scales not attainable using current sensing technologies.

2005-04-01

336

British Library Electronic Table of Contents (United Kingdom)

In contrast to language, where pitch patterns consist of continuous and curvilinear contours, musical pitch consists of relatively discrete, stair-stepped sequences of notes. Behavioral and neurophysiological studies suggest that both tone-language and music experience enhance the representation of pitch cues associated with a listener's domain of expertise, e.g., curvilinear pitch in language, discrete scale steps in music. We compared brainstem frequency-following responses (FFRs) of English-speaking musicians (musical pitch experience) and native speakers of Mandarin Chinese (linguistic pitch experience) elicited by rising and falling tonal sweeps that are exemplary of Mandarin tonal contours but uncharacteristic of the pitch patterns typically found in music. In spite of musicians' unf...

2011-01-01

337

Multiple treatment comparison meta-analyses: a step forward into complexity

Moral Judgments Recruit Domain-General Valuation Mechanisms to Integrate Representations of Probability and Magnitude

The use of meta-analysis has become increasingly useful for clinical and policy decision making. A recent development in meta-analysis, multiple treatment comparison (MTC) meta-analysis, provides inferences on the comparative effectiveness of interventions that may have never been directly evaluated in clinical trials. This new approach may be confusing for clinicians and methodologists and raises specific challenges relevant to certain areas of medicine. This article addresses the methodological concepts of MTC meta-analysis, including issues of heterogeneity, choice of model, and adequacy of sample sizes. We address domain-specific challenges relevant to disciplines of medicine, including baseline risks of patient populations. We conclude that MTC meta-analysis is a useful tool in the context of comparative effectiveness and requires further study, as its utility and transparency will likely predict its uptake by the research and clinical community.

2011-05-27

338

British Library Electronic Table of Contents (United Kingdom)

Summary Many important moral decisions, particularly at the policy level, require the evaluation of choices involving outcomes of variable magnitude and probability. Many economic decisions involve the same problem. It is not known whether and to what extent these structurally isomorphic decisions rely on common neural mechanisms. Subjects undergoing fMRI evaluated the moral acceptability of sacrificing a single life to save a larger group of variable size and probability of dying without action. Paralleling research on economic decision making, the ventromedial prefrontal cortex and ventral striatum were specifically sensitive to the "expected moral value" of actions, i.e., the expected number of lives lost/saved. Likewise, the right anterior insula was specifically sensitive to outcome p...

2010-01-01

339

Microstructure analysis of nanocrystalline powders by X-ray diffraction

Measurement of the antiproton/proton ratio in the few-TeV energy range with ARGO-YBJ

The use of X-ray diffraction line profile analysis for the study of nanocrystalline powders is described. The fundamentals of the theory are presented in terms of crystallite/domain size, size distribution, lattice distortion, dislocations density and stacking faults. Line profile parameters and the methods of pattern fitting introduced to overcome the diffraction-line overlap problem are discussed. The approaches based of the integral breadth of the measured line profiles and the Fourier method are discussed. In addition, simplified approaches are also commented. Representative examples are selected to illustrate various cases of microstructure, such as nanomaterials with strain-free spherical nano crystallites, strain-free crystallites with anisotropic crystallite shape, anisotropic crystallites with microstrains and spherical crystallites with dislocation densities and crystallite size distributions. (author)

2001-09-23

340

Mathematical modelling of air pollution in the Athens basin

Cosmic ray antiprotons provide an important probe for the study of cosmic ray propagation in the interstellar space and to investigate the existence of Galactic dark matter. The ARGO-YBJ experiment is observing the Moon shadow with high statistical significance at an energy threshold of a few hundred GeV. Using all the data collected until November 2009, we set two upper limits on the antip/p flux ratio: 5% at an energy of 1.4 TeV and 6% at 5 TeV with a confidence level of 90%. In the few-TeV range the ARGO-YBJ results are the lowest available, useful to constrain models for antiproton production in antimatter domains.

2010-01-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

341

Magnetic layer formation on plasma nitrided CoCrMo alloy

This paper presents research work concerning the mathematical modelling of air pollution in the Athens basin. A mathematical model based on aerodynamics and conservation equations together with turbulence modelling in body-fitted coordinates is used to provide the necessary input information to a similar but more detailed (i.e. small scale) model around Athens. Both models consist of solving the full Navier-Stokes equations and take into account the precise topography of the region. Different roughness heights are used for sea, coastal regions and land. The smaller scale model makes use of a two-equation turbulence model ({kappa}-{epsilon}) and the large scale model assumes a constant turbulence viscosity. The pollutant sources used in these models are based on actual emissions in the Athens area and are distributed in space. The results of this work appear promising and demonstrate the capability of the model as a tool for providing flow fields and pollution levels in complicated ...

1991-12-31

342

British Library Electronic Table of Contents (United Kingdom)

In this study structural and magnetic character of the expanded austenite phase (gN) layer formed on a medical grade CoCrMo alloy by a low-pressure Radio-Frequency plasma nitriding process was investigated. The formation of the expanded austenite phase is facilitated at a substrate temperature near 400^oC for 1, 2, 4, 6 and 20h under a gas mixture of 60% N2-40% H2. The magnetic state of the gN layers was determined by a surface sensitive technique, magneto-optic Kerr effect (MOKE), and with a scanning probe microscope in magnetic force mode (MFM). Strong evidence for the ferromagnetic nature of the gN-(Co,Cr,Mo) phase is provided by the observation of stripe domain structures and the hysteresis loops. The ferromagnetic state for the gN phase observed here is mainly linked to large lattice ...

2011-01-01

343

Learning from a mouse - how adoption of Disney methods could assist development of CANDU control centres

Kinematics and flow characteristics of a magnetic actuated multi-cilia configuration

Many organizations are challenged with the tasks of identifying customer needs and expectations for their products, anticipating future product needs, communicating a future product vision to clients, and designing with today's technology to bring a future vision to successful realization. The design evolution of plant control centres is one aspect of CANDU development that faces such challenges. The Disney Corporation is an example of an organization that has been successful in consistently meeting these challenges for over fifty years; and some of the design practices proven in moviemaking, theme park and resort layout, and vacation experience organization may be helpful and effective when applied in other domains. This paper summarizes the findings from an examination of Disney Corporation design practices, and suggests how some practices could be used to simplify and enhance the design of future CANDU control centres. (author)

2005-07-01

344

British Library Electronic Table of Contents (United Kingdom)

The current paper continues the analysis of a completely novel method of fluid manipulation technology in micro-fluidics systems, inspired by nature, namely by the mechanisms found in ciliates. More information on this subject can be found at http://www.hitech-projects.com/euprojects/artic/. In order to simulate the drag forces acting on an array of artificial cilia, we have developed a computer code that is based on fundamental solutions of Stokes flow in a semi-infinite domain. The actuation mechanism consists of a bi-directional rotating excitation magnetic field. The magnetization induced by the magnetic field was calculated in a separate routine based on the Integral Nonlinear Equations Approach with 1D discretization of wire (cilium). Time averaged x-coordinate mass flow rates, strea...

2011-01-01

345

KMeyeDB: a graphical database of mutations in genes that cause eye diseases

British Library Electronic Table of Contents (United Kingdom)

KMeyeDB () is a database of human gene mutations that cause eye diseases. We have substantially enriched the amount of data in the database, which now contains information about the mutations of 167 human genes causing eye-related diseases including retinitis pigmentosa, cone-rod dystrophy, night blindness, Oguchi disease, Stargardt disease, macular degeneration, Leber congenital amaurosis, corneal dystrophy, cataract, glaucoma, retinoblastoma, Bardet-Biedl syndrome, and Usher syndrome. KMeyeDB is operated using the database software MutationView, which deals with various characters of mutations, gene structure, protein functional domains, and polymerase chain reaction (PCR) primers, as well as clinical data for each case. Users can access the database using an ordinary Internet browser wi...

2010-01-01

346

Human and rat mast cell high-affinity immunoglobulin E receptors: Characterization of putative. alpha. -chain gene products

How do mathematicians learn math?: resources and acts for constructing and understanding mathematics

The authors have cloned and determined the entire nucleotide sequence of cDNAs corresponding to the putative {alpha} subunits of the human and rat mast cell high-affinity IgE receptors. Both human and rat cDNAs encode an NH{sub 2}-terminal signal peptide, two immunoglobulin-like extracellular domains (encoded by discrete exons), a hydrophobic transmembrane region, and a positively charged cytoplasmic tail. The human and rat {alpha} subunits share an overall homology with one another and the immunoglobulin gene family, suggesting that they arose from a common ancestral gene and continue to share structural homology with their ligands. In addition, the rat gene is transcribed into at least three distinct forms, each of which yields a somewhat different coding sequence.

1988-03-01

347

British Library Electronic Table of Contents (United Kingdom)

In this paper, we present an analytic framework for investigating expert mathematical learning as the process of building a network of mathematical resources by establishing relationships between different components and properties of mathematical ideas. We then use this framework to analyze the reasoning of ten mathematicians and mathematics graduate students that were asked to read and make sense of an unfamiliar, but accessible, mathematical proof in the domain of geometric topology. We find that experts are more likely to refer to definitions when questioning or explaining some aspect of the focal mathematical idea and more likely to refer to specific examples or instantiations when making sense of an unknown aspect of that idea. However, in general, they employ a variety of types of m...

2011-01-01

348

High-gain harmonic generation free electron laser seeded by few-cycle laser

Hepatitis C virus core upregulates the methylation status of the RASSF1A promoter through regulation of SMYD3 in hilar cholangiocarcinoma cells

Tunable output wavelength is an important character of a free electron laser (FEL). As generally understood, to alter the wavelength of a high-gain harmonic generation (HGHG) FEL laser, the seed laser must be tunable. A few-cycle, high intensity laser obtained by optical compression usually has pretty broad bandwidth in the spectral domain, which can be used as the seed laser of a HGHG and may open the possibility to approach a HGHG scheme with fully tunable wavelength. In this paper, a HGHG FEL seeded by a few-cycle laser is theoretically discussed and numerically investigated. A few-cycle seed laser significantly influences HGHG FEL performance, especially in output wavelength tuning. For a HGHG FEL seeded by a 4-cycle 786 nm laser, output wavelength tunability range up to 14.9% of the central wavelength 262 nm is observed by adjusting the resonant condition.

2008-06-07

349

British Library Electronic Table of Contents (United Kingdom)

Increasing evidence has been accumulated indicating the important role of epigenetic regulation in tumor genesis. Previously, we observed that the transfection of hepatitis C virus core (HCVc) protein led to malignant transformation in normal biliary cells, and that tumor suppressor gene RASSF1A was downregulated in many hilar cholangiocarcinoma patients by hypermethylation in the promoter region. In the present study, we found SET and MYND domain-containing protein 3 (SMYD3), a novel histone methyltransferase, was overexpressed in cholangiocarcinoma patients especially in those with HCV infection. Transfection of HCVc into hilar cholangiocarcinoma cell lines QBC939 and FRH0201 could upregulate the expression of SMYD3 and promote cell growth, which was consistent with the results of our cl...

2011-01-01

350

Generation and Characterization of Monoclonal Antibodies to Human Keratinocyte Growth Factor Receptor

British Library Electronic Table of Contents (United Kingdom)

Keratinocyte growth factor receptor (KGFR) and fibroblast growth factor receptor (FGFR) 2c share identical amino acid sequences, except for a 46-amino acid domain in the extracellular region. Monoclonal antibodies (MAbs) specific to KGFR have not been reported nor are commercially available. In this study, we generated murine MAbs specific to KGFR in non-obese diabetic (NOD) mice using a modified Repeated Immunizations at Multiple Sites (RIMMS) technology. Stable cell lines expressing the full-length human KGFR or FGFR2c were produced to facilitate the identification of KGFR-specific MAbs. Following the initial screening of hybridoma clones with a fluorescence-based, confocal cell detection method and ELISA, KGFR-specific MAbs were selected and confirmed by flow cytometry and Western blot ...

2006-01-01

351

Fourier analysis of energy transfer data obtained by simulating a 14-MeV #alpha#-particle in water

Final report: technical contributions to the development of incipient fault detection/location instrumentation

Data from Monte Carlo transport codes are used to model radiobiological effects. We previously reported the Fourier analysis of ionization data generated by simulating a 500-keV proton traversing water. Here, we extend Fourier analysis to energy transfer data of another radiation type, a 14-MeV #alpha#-particle. A radiobiological model based on this frequency-domain analysis views cell as an information processing system . It lends itself naturally to traditional engineering analyses. One engineering principle-the output response of a linear system to random signal-is applied here to explain the fact that there is measurable difference in the magnitude of the biological effectiveness when a given biological system is irradiated with two different radiation types of the same Linear Energy Transfer (LET).

2010-01-15

352

Fault diagnosis of roller bearing using fuzzy classifier and histogram features with focus on automatic rule learning

The transmission of electrical energy by use of underground cables is increasing. Fault location techniques have certain limitations; incipient fault detection and location would help reduce the maintenance cost of these lines as well as improve the reliability of service. The report discusses some test results related to RF-probing techniques applied to high-voltage transmission lines. The high-frequency losses and attenuation in high-voltage cables places certain ultimate limitations on RF-probing techniques for incipient fault detection. Time-domain reflectrometry methods were employed to assess the RF-transmission properties of high-voltage cables at frequencies as high as 6 GHz. Fast-Fourier-transform deconvolution was used to obtain loss measurements as a function of frequency. The loss mechanisms were identified. The measurement hardware and methods are discussed as well as analysis approach leading to the conclusions.

1986-04-01

353

British Library Electronic Table of Contents (United Kingdom)

Roller bearing is one of the most widely used elements in rotary machines. Condition monitoring of such elements is conceived as pattern recognition problem. Pattern recognition has three main phases: feature extraction, feature selection and feature classification. Histogram features can be used for fault diagnosis of roller bearing. This paper presents the use of decision tree for selecting best few histogram features (bin ranges) that will discriminate the fault conditions of the bearing from given train samples. These features are extracted from vibration signals. A rule set is formed from the extracted features and fed to a fuzzy classifier. The rule set necessary for building the fuzzy classifier is obtained largely by intuition and domain knowledge. This paper also presents the usag...

2011-01-01

354

Estimation of plasma density by surface plasmons for surface-wave plasmas

Equivalence Checking in Embedded Systems Design Verification

An estimation method of plasma density based on surface plasmons theory for surface-wave plasmas is proposed. The number of standing-wave is obtained directly from the discharge image, and the propagation constant is calculated with the trim size of the apparatus in this methods, then plasma density can be determined with the value of 9.1 x 1017 m-3. Plasma density is measured using a Langmuir probe, the value is 8.1 x 1017 m-3 which is very close to the predicted value of surface plasmons theory. Numerical simulation is used to check the number of standing-wave by the finite-difference time-domain (FDTD) method also. All results are compatible both of theoretical analysis and experimental measurement. (authors)

2008-12-01

355

Energy R and D. Geothermal energy and underground reservoirs; R et D energie. Geothermie et reservoirs souterrains

In this report we focus on some aspects related to modeling and formal verification of embedded systems. Many models have been proposed to represent embedded systems . These models encompass a broad range of styles, characteristics, and application domains and include the extensions of finite state machines, data flow graphs, communication processes and Petri nets. In this report, we have used a PRES+ model (Petri net based Representation for Embedded Systems) as an extension of classical Petri net model that captures concurrency, timing behaviour of embedded systems; it allows systems to be representative in different levels of abstraction and improves expressiveness by allowing the token to carry information. Modeling using PRES+, as discussed above, may be convenient for specifying the input behaviour because it supports concurrency. However, there is no equivalence checking method reported in the literature for PRES+ models to the best of our knowledge. In ...

2010-01-01

356

EEMD method and WNN for fault diagnosis of locomotive roller bearings

Geothermal energy appears as a viable economic alternative among the different renewable energy sources. The French bureau of geological and mining researches (BRGM) is involved in several research and development programs in the domain of geothermal energy and underground reservoirs. This document presents the content of 5 programs: the deep hot dry rock system of Soultz-sous-Forets (construction and testing of the scientific pilot, modeling of the reservoir structure), the development of low and high enthalpy geothermal energy in the French West Indies, the comparison of the geothermal development success of Bouillante (Guadeloupe, French West Indies) with the check of the geothermal development of Nyssiros (Greece) and Pantelleria (Italy), the development of the high enthalpy geothermal potentialities of Reunion Island, and the underground storage of CO{sub 2} emissions in geologic formations (deep aquifers, geothermal reservoirs, abandoned mines or oil ...

2001-07-01

357

British Library Electronic Table of Contents (United Kingdom)

The ensemble empirical mode decomposition (EEMD) can overcome the mode mixing problem of the empirical mode decomposition (EMD) and therefore provide more precise decomposition results. Wavelet neural network (WNN) possesses the advantages of both wavelet transform and artificial neural networks. This paper combines the merits of EEMD and WNN to propose an automated and effective fault diagnosis method of locomotive roller bearings. First, the vibration signals captured from the locomotive roller bearings are preprocessed by EEMD method and intrinsic mode functions (IMFs) are produced. Second, a kurtosis based method is presented and used to select the sensitive IMF. Third, time- and frequency-domain features are extracted from the sensitive IMF, its frequency spectrum and its envelope spe...

2011-01-01

358

Distinguishing two groups of flavin reductases by analyzing the protonation state of an active site carboxylic acid

British Library Electronic Table of Contents (United Kingdom)

Abstract Flavin-containing reductases are involved in a wide variety of physiological reactions such as photosynthesis, nitric oxide synthesis, and detoxification of foreign compounds, including therapeutic drugs. Ferredoxin-NADP(H)-reductase (FNR) is the prototypical enzyme of this family. The fold of this protein is highly conserved and occurs as one domain of several multidomain enzymes such as the members of the diflavin reductase family. The enzymes of this family have emerged as fusion of a FNR and a flavodoxin. Although the active sites of these enzymes are very similar, different enzymes function in opposite directions, that is, some reduce oxidized nicotinamide adenine dinucleotide phosphate (NADP+) and some oxidize reduced nicotinamide adenine dinucleotide phosphate (NADPH). In t...

2011-01-01

359

Discretization of complex 3-D flow domains with adaptive hybrid grids

Design and control of six degree-of-freedom active vibration isolation table.

There is an ever increasing demand to perform flow simulations that incorporate the complete details of geometry as well as sophisticated flow physics. This has led to the development of numerical algorithms that can simulate the actual flow phenomena with greater fidelity. However, the success of these algorithms hinges on the grid that models the geometry. Grid generation methods for 2-D models have long existed and the general lack of complexity of the simpler 2-D models has not quite challenged the efforts in this area. However, demands for generating better 3-D geometric models for flow simulations involving complex geometries have completely changed the perspective of grid generation strategies. As a consequence, grid generation efforts have earned equal significance as that of numerical solver efforts.

1996-12-31

360

Demand Analysis with Partial Predicates

A six-axis active vibration isolation system (AVIS) is designed by using the direct driven guide and ball contact mechanisms in order to have no cross-coupling between actuators. The point contact configuration gives an advantage of having an easy assembly of eight voice coil actuators to an upper and a base plate. A voice coil actuator is used since it can provide a large displacement and sufficient bandwidth required for vibration control. The AVIS is controlled considering the effect of flexible vibration mode in the upper plate and velocity sensor dynamics. A loop shaping technique and phase margin condition are applied to design a vibration controller. The performances of the AVIS are investigated in the frequency domain and finally validated by comparing with the passive isolation system. The scanning profiles of the specimen are compared together by using the atomic force microscope. The robustness of the AVIS is verified by showing the impulse response. ...

2010-03-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

361

Cooperative use of unmanned sea surface and micro aerial vehicles at Hurricane Wilma

In order to alleviate the inefficiencies caused by the interaction of the logic and functional sides, integrated languages may take advantage of \\emph{demand} information -- i.e. knowing in advance which computations are needed and, to which extent, in a particular context. This work studies \\emph{demand analysis} -- which is closely related to \\emph{backwards strictness analysis} -- in a semantic framework of \\emph{partial predicates}, which in turn are constructive realizations of ideals in a domain. This will allow us to give a concise, unified presentation of demand analysis, to relate it to other analyses based on abstract interpretation or strictness logics, some hints for the implementation, and, more important, to prove the soundness of our analysis based on \\emph{demand equations}. There are also some innovative results. One of them is that a set constraint-based analysis has been derived in a stepwise manner using ideas taken from the area of program ...

2006-01-01

362

British Library Electronic Table of Contents (United Kingdom)

On Oct. 24, 2005, Hurricane Wilma, a category 5 storm, made landfall at Cape Romano, Florida. Three days later, the Center for Robot-Assisted Search and Rescue at the University of South Florida deployed an iSENYS helicopter and a prototype unmanned water surface vehicle, AEOS-1, to survey damage in parts of Marco Island, 14 km from landfall. The effort was the first known use of unmanned sea surface vehicles (USVs) for emergency response and established their suitability for the recovery phase of disaster management by detecting damage to seawalls and piers, locating submerged debris (moorings and handrails), and determining safe lanes for sea navigation. It provides a preliminary domain theory of postdisaster port and littoral inspection with unmanned vehicles for use by the human-robot ...

2008-01-01

363

Control of linear accelerator noise in the Los Alamos free-electron laser (FEL)

Construction of the maximal solution of Backus? problem in geodesy and geomagnetism

FELs require tight control of the amplitudes and phase of the fields in two linear accelerator tanks to obtain stable lasing. The accelerator control loops must establish constant, stable, repeatable amplitudes and phases of the rf fields and must have excellent bandwidth to control high-frequency noise components. A model of the feedback loops has been developed that agrees well with measurements and allows easy substitution of components and circuits, thus reducing breadboarding requirements. The model permits both frequency and time-domain analysis. The accelerator control scheme and model are described and the control of noise in feedback loops is discussed, showing how low-frequency-noise components (errors) can be corrected, but high-frequency-noise components (errors) are actually amplified by the feedback circuit. Measurements of noise in both open- and closed-loop modes is shown and comparison is made with results from the model calculations.

1986-09-01

364

British Library Electronic Table of Contents (United Kingdom)

The (simplified) Backus? Problem (BP) consists in finding a harmonic function u on the domain exterior to the three dimensional unit sphere S, such that u tends to zero at infinity and the norm of the gradient of u takes prescribed values g on S. Except for a change of sign, the solution is not unique in general. However, there is uniqueness of solutions in the class of functions with the additional property that the radial component of the gradient of u on S is nonpositive. This is the geodetically relevant case. If a solution u with this property exists, then u is the maximal solution of the problem (and -u the minimal one). In this paper we propose a method of successive approximations to get this particular solution of BP and prove the convergence for functions g close to a constant fu...

2011-01-01

365

Computational Relativistic Astrophysics With Adaptive Mesh Refinement: Testbeds

Bound states, tachyons, and restoration of symmetry in the 1/N expansion

We have carried out numerical simulations of strongly gravitating systems based on the Einstein equations coupled to the relativistic hydrodynamic equations using adaptive mesh refinement (AMR) techniques. AMR coalescences of neutron stars can now be simulated with sufficient resolution covering the neutron stars while having the computational domain extend to the local wave zone. We show an AMR simulation carried out with a workstation having an accuracy equivalent to that of a 1025^3 regular uni-grid simulation, which is, to the best of our knowledge, larger than all previous simulations of similar NS systems on supercomputers. We believe the capability opens new possibilities in general relativistic simulations.

2005-01-01

366

Bioinformatic analysis of BBTV satellite DNA in Hainan

An extensive analysis of the 1/N expansion of O(N)-symmetric lambdaphi"4 theory in four dimensions shows it to be a consistent approximation method. It is confirmed that the ground state of the theory is O(N(-symmetric, and that spontaneous symmetry breaking is not possible in the large-N limit. The Green's functions are free of tachyons if constructed relative to this ground state. A natural upper bound is derived for the parameters of the theory to ensure the existence of a ground state. In the strong-coupling domain there exist a bound state and a resonance in the identity representation of the O(N) group, which disappear in the weak-coupling regime. It is shown that, to leading order in N, a zero-mass interacting ''charged'' boson cannot be sustained in this theory. If the boson mass goes to zero, the model becomes a free-field theory.

367

British Library Electronic Table of Contents (United Kingdom)

Banana bunchy top virus (BBTV), family Nanaviridae, genus Babuvirus, is a single stranded DNA virus (ssDNA) that causes banana bunchy top disease (BBTD) in banana plants. It is the most common and most destructive of all viruses in these plants and is widespread throughout the Asia-Pacific region. In this study we isolated, cloned and sequenced a BBTV sample from Hainan Island, China. The results from sequencing and bioinformatics analysis indicate this isolate represents a satellite DNA component with 12 DNA sequences motifs. We also predicted the physical and chemical properties, structure, signal peptide, phosphorylation, secondary structure, tertiary structure and functional domains of its encoding protein, and compare them with the corresponding quantities in the replication initiatio...

2011-01-01

368

Atmospheric Gravity Perturbations Measured by Ground-Based Interferometer with Suspended Mirrors

Analysis of the different slip systems activated by tension in a #alpha#/#beta# titanium alloy in relation with local crystallographic orientation

A possibility of geophysical measurements using the large scale laser interferometrical gravitational wave antenna is discussed. An interferometer with suspended mirrors can be used as a gradiometer measuring variations of an angle between gravity force vectors acting on the spatially separated suspensions. We analyze restrictions imposed by the atmospheric noises on feasibility of such measurements. Two models of the atmosphere are invoked: a quiet atmosphere with a hydrostatic coupling of pressure and density and a dynamic model of moving region of the density anomaly (cyclone). Both models lead to similar conclusions up to numerical factors. Besides the hydrostatic approximation, we use a model of turbulent atmosphere with the pressure fluctuation spectrum f^{-7/3} to explore the Newtonian noise in a higher frequency domain (up to 10 Hz) predicting the gravitational noise background for modern gravitational wave detectors. Our estimates show that this could pose ...

2003-01-01

369

Analysis of modified Van der Pol's oscillator using He's parameter-expanding methods

The gliding modes of a duplex Ti-6Al-4V titanium alloy were investigated through in situ (scanning electron microscopy) tensile tests. A method based on electron back-scattering diffraction (EBSD) measurements was used to identify activated slip systems. The approach applied to a large number of grains allowed a statistical analysis of the nature (basal, prismatic, pyramidal) and distribution of the slip systems according to the crystallographic texture. A discussion concerning the pertinence of Schmid's law to explain the occurrence and succession of slip events is then proposed. The domain in favor of each type of slip system is finally presented by using inverse pole figures mapped with Schmid's factor iso-curves.

2005-02-01

370

British Library Electronic Table of Contents (United Kingdom)

In this work, a powerful analytical method, called He's parameter-expanding methods (HPEM) is used to obtain the exact solutions of non-linear modified Van der Pol's oscillator. The classical Van der Pol equation with delayed feedback and a modified equation where a delayed term provides the damping are considered. It is shown that one term in series expansions is sufficient to obtain a highly accurate solution, which is valid for the whole solution domain. Comparison of the obtained solution with those obtained using perturbation method shows that this method is effective and convenient to solve this problem. This method introduces a capable tool to solve this kind of non-linear problems.

2010-01-01

371

Analysis of microwave induced natural convection in a single mode cavity (Influence of sample volume, placement, and microwave power level)

British Library Electronic Table of Contents (United Kingdom)

The heating of water layer using microwave oven with a rectangular waveguide has been studied both numerically and experimentally. The mathematical model is validated with the experimental data. The transient Maxwell's equations are solved by using the Finite Difference Time Domain (FDTD) method to describe the electromagnetic field inside the waveguide and sample. The temperature profile and velocity field within sample are determined by the solutions of the momentum, energy and Maxwell's equations. In this study, the effects of physical parameters, e.g. microwave power level, placement of sample inside the waveguide, volume of sample, are studied. The distribution of electric field, temperature profile and velocity field are presented in details. The results show good agreement between s...

2012-01-01

372

An improved noise-robust voice activity detector based on hidden semi-Markov models

British Library Electronic Table of Contents (United Kingdom)

To improve the performance of voice activity detector (VAD) in noisy environments, this paper concentrates on three critical aspects related to noise robustness including speech features, feature distributions and temporal dependence. Based on the statistic on TIMIT and NOIZEUS, Mel-frequency cepstrum coefficients (MFCCs) are selected as speech features, Gaussian Mixture distributions (GMD) are applied to associate the observations in MFCC domain with both speech and non-speech states, and Weibull and Gamma distributions are used to explicitly model noise and speech durations, respectively. To integrate these aspects into VAD, the hidden semi-Markov model (HSMM) as a generalized hidden Markov model (HMM) is introduced first. Then the VAD decision is made according to the likelihood ratio t...

2011-01-01

373

An adaptive power system stabilizer based on the self-optimizing pole shifting control strategy

An Intrinsic Approach to Forces in Magnetoelectric Media

An adaptive power system stabilizer (APSS) employing a new self-optimizing pole shifting control strategy and its application to a power system are described in this paper. Based on an identified model of the system, the control is computed by an algorithm which shifts the closed-loop poles of the system to some optimal locations inside the unit circle in the z-domain to minimize a given performance criterion. With the self-optimization property, outside intervention in the controller design procedure is minimized, thus simplifying the tuning procedure during commissioning. Also, a new method of calculating the variable forgetting factor in real-time parameter identification is discussed. Studies show that the proposed APSS can provide good damping of the power system over a wide operating range and significantly improve the dynamic performance of the system.

1993-12-01

374

Amphiphysin (Amph) maps to the proximal region of mouse chromosome 13

This paper offers a conceptually straightforward method for the calculation of stresses in polarisable media based on the notion of a drive form and its property of being closed in spacetimes with symmetry. After an outline of the notation required to exploit the powerful exterior calculus of differential forms, a discussion of the relation between Killing isometries and conservation laws for smooth and distributional drive forms is given. Instantaneous forces on isolated spacetime domains and regions with interfaces are defined, based on manifestly covariant equations of motion. The remaining sections apply these notions to media that sustain electromagnetic stresses, with emphasis on homogeneous magnetoelectric material. An explicit calculation of the average pressure exerted by a monochromatic wave normally incident on a homogeneous, magnetoelectric slab in vacuo is presented and the concluding section summarizes how this pressure depends on the parameters in ...

2008-01-01

375

Alignment of nematic liquid crystals on mixed Langmuir-Blodgett mono-layers

Amphiphysin is a protein concentrated in neuronal synapses and peripherally associated with neurotransmitter vesicles. It is expressed in many neurons of the central and peripheral nervous systems, in the adrenal medulla, in the anterior and posterior pituitary, in cell lines of the endocrine pancreas, and in spermatocytes. Its subcellular localization and tissue distribution indicate a potential involvement in mechanisms of regulated exocytosis. A role in the dynamic organization of the membrane-associated cytoskeleton is suggested by structural homology to the products of two yeast genes, RVS161 and RVS167, whose mutation results in an abnormal actin distribution, disturbs budding morphology, and impairs cell entry into stationary phase. Limited stretches of sequence similarity, including an SH3 domain, are also shared with other actin-binding proteins. Amphiphysin is the dominant autoantigen in paraneoplastic Stiff-Man syndrome, a neurological autoimmune ...

1995-07-20

376

Alignment and alignment dynamics of nematic liquid crystals on Langmuir-Blodgett mono-layers

Mono-layers of stearic and behenic acids and mixtures of them in different proportions, deposited with the Langmuir-Blodgett technique, were used to study the alignment and the alignment dynamics in nematic liquid crystal cells. A relaxation process from a splay-bend flow induced metastable orientation to the homeotropic one occurs. The lifetime of the metastable state was found to depend on the mono-layer composition. The transition between the homeotropic and the conical anchoring was found to be irreversible in the case of the mixed aligning mono-layers: on cooling from the isotropic phase a quasi-planar nematic state (schlieren texture) appears. It is stable in a range of a few degrees below the clearing point and, on decreasing the temperature, relaxes to the homeotropic state in form of expanding domains.

1998-01-01

377

Advances in Modeling of Scanning Charged-Particle-Microscopy Images

Mono-layers of stearic and behenic acids deposited with the Langmuir-Blodgett technique, were used as aligning films in nematic liquid crystal cells. During the filling process the liquid crystal adopts a deformed quasi-planar alignment with splay-bend deformation and preferred orientation along the filling direction. This state is metastable and transforms with time into homeotropic once the flow has ceased. The transition is accompanied by formation of disclination lines which nucleate at the edges of the cell. The lifetime of the metastable splay-bend state was found to depend on the cell thickness. On heating, anchoring transition from quasi-homeotropic to degenerate tilted alignment in form of circular domains takes place near the transition to the isotropic phase. The anchoring transition is reversible with a small hysteresis.

1998-01-01

378

A symbolic computing environment for doing calculations in quantum field theory

Modeling artificial scanning electron microscope (SEM) and scanning ion microscope images has recently become important. This is because of the need to provide repeatable images with a priori determined parameters. Modeled artificial images are highly useful in the evaluation of new imaging and metrological techniques, like image-sharpness calculation, or drift-corrected image composition (DCIC). Originally, the NIST-developed artificial image generator was designed only to produce the SEM images of gold-on-carbon resolution sample for image-sharpness evaluation. Since then, the new improved version of the software was written in C++ programming language and is in the Public Domain. The current version of the software can generate arbitrary samples, any drift function, and many other features. This work describes scanning in charged-particle microscopes, which is applied both in the artificial image generator and the DCIC technique. As an example, the performance ...

2010-01-01

379

A superconductor to superfluid phase transition in liquid metallic hydrogen

A computational environment, as a set of MapleV R.3 routines for doing symbolic calculations in Quantum Field Theory, is presented. The Q F T package`s routines extend the standard MapleV computational domain by introducing representations for anti commutative and noncommutative objects, tensors, spinors and gauge fields, as well as related objects and procedures (Dirac matrices, differential operators, functional differentiation w.r.t indexed fields, sum rule for repeated indices, etc.). Furthermore, the Q F T routines permit the user-definition of algebra rules for the commutation/ anti commutation of operators, to be taken into account during the calculations. (author) 2 refs.

1997-12-31

380

A sum rule approach to the violation of Dashen`s theorem; Une approache de la violation du theoreme de Dashen par les regles de somme

Although hydrogen is the simplest of atoms, it does not form the simplest of solids or liquids. Quantum effects in these phases are considerable (a consequence of the light proton mass) and they have a demonstrable and often puzzling influence on many physical properties, including spatial order. To date, the structure of dense hydrogen remains experimentally elusive. Recent studies of the melting curve of hydrogen indicate that at high (but experimentally accessible) pressures, compressed hydrogen will adopt a liquid state, even at low temperatures. In reaching this phase, hydrogen is also projected to pass through an insulator-to-metal transition. This raises the possibility of new state of matter: a near ground-state liquid metal, and its ordered states in the quantum domain. Ordered quantum fluids are traditionally categorized as superconductors or superfluids; these respective systems feature dissipationless electrical currents or mass flow. Here we report an ...

2004-01-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

381

A study on the power system stabilizer using discrete-time adaptive sliding mode control

A classic sum rule by Das et al. is extended to seven of the low-energy constant K{sub i}, introduced by Urech, which parameterizes electromagnetic corrections at chiral order O(e{sup 2}p{sup 2}). Using the spurion formalism, a simple convolution representation is shown to hold and the structure in terms of the chiral renormalization scale, QCD renormalization scale and the QED gauge parameter is displayed. The role of the resonances is studied as providing rational interpolants to relevant QCD n-point functions in the Euclidean domain. A variety of asymptotic constraints must be implemented which have phenomenological consequences. A current assumption concerning the dominance of the lowest-lying resonances is shown clearly to fail in some cases. (author)

1999-10-01

382

A report on the CCNA 2007 professional practice analysis.

In this paper the newly developed discrete-time adaptive sliding mode control method is proposed and applied to the power system stabilization problem. In contrast to the conventional continuous-time sliding mode controller, the proposed method is developed in the discrete-time domain and based on the input/output measurements instead of the continuous-time and the full-states feedback, respectively. Because the proposed control method has the adaptivity property in addition to the natural robustness property of the sliding mode control, it is possible to design the power system stabilizer which can overcome both the minor variations of the parameters of the power system and the diverse operating conditions and faults of the power system. Mathematical proof and the various computer simulations are done to verify the performance and stability of the proposed method. (author). 14 refs., 12 figs., 1 tab.

1996-02-01

383

A Mediation Framework for Mobile Web Service Provisioning

The purpose of this column is to present the results of the 2007 Professional Practice Analysis (PPA) of the field of nurse anesthesia, conducted by the Council on Certification of Nurse Anesthetists. The PPA used survey and rating scale methodologies to collect data regarding the relative emphasis of various aspects of the nurse anesthesia knowledge domain and competencies. A total of 3,805 survey responses were analyzed using the Rasch rating scale model, which aggregates and transforms ordinal (rating scale) responses into linear measures of relative importance and frequency. Summaries of respondent demographics and educational and professional background are provided, as well as descriptions of how the survey results are used to develop test specifications. The results of this analysis provide evidence for the content outline and test specifications (content percentages) and thus serve as a basis of content validation for the National Certification Examination. ...

2009-06-01

384

A Laplacian approach to multi-oriented text detection in video.

Web Services and mobile data services are the newest trends in information systems engineering in wired and wireless domains, respectively. Web Services have a broad range of service distributions while mobile phones have large and expanding user base. To address the confluence of Web Services and pervasive mobile devices and communication environments, a basic mobile Web Service provider was developed for smart phones. The performance of this Mobile Host was also analyzed in detail. Further analysis of the Mobile Host to provide proper QoS and to check Mobile Host's feasibility in the P2P networks, identified the necessity of a mediation framework. The paper describes the research conducted with the Mobile Host, identifies the tasks of the mediation framework and then discusses the feasible realization details of such a mobile Web Services mediation framework.

2010-01-01

385

A Comprehensive Survey of Data Mining-based Fraud Detection Research

In this paper, we propose a method based on the Laplacian in the frequency domain for video text detection. Unlike many other approaches which assume that text is horizontally-oriented, our method is able to handle text of arbitrary orientation. The input image is first filtered with Fourier-Laplacian. K-means clustering is then used to identify candidate text regions based on the maximum difference. The skeleton of each connected component helps to separate the different text strings from each other. Finally, text string straightness and edge density are used for false positive elimination. Experimental results show that the proposed method is able to handle graphics text and scene text of both horizontal and nonhorizontal orientation. PMID:20733217

2011-02-01

386

The neuronal nicotinic acetylcholine receptor {alpha}7 subunit gene: Cloning, mapping, structure, and targeting in mouse

This survey paper categorises, compares, and summarises from almost all published technical and review articles in automated fraud detection within the last 10 years. It defines the professional fraudster, formalises the main types and subtypes of known fraud, and presents the nature of data evidence collected within affected industries. Within the business context of mining the data to achieve higher cost savings, this research presents methods and techniques together with their problems. Compared to all related reviews on fraud detection, this survey covers much more technical articles and is the only one, to the best of our knowledge, which proposes alternative data and solutions from related domains.

2010-01-01

387

The Sorcerer II Global Ocean Sampling Expedition: Expanding theUniverse of Protein Families

The neuronal nicotinic acetylcholine receptor {alpha}7 subunit is a member of a family of ligand-gated ion channels, and is the only subunit know to bind {alpha}-bungarotoxin in mammalian brain. {alpha}-Bungarotoxin binding sites are known to be more abundant in the hippocampus of mouse strains that are particularly sensitive to nicotine-induced seizures. The {alpha}7 receptor is highly permeable to calcium, which could suggest a role in synaptic plasticity in the nervous system. Auditory gating deficiency, an abnormal response to a second auditory stimulus, is characteristic of schizophrenia. Mouse strains that exhibit a similar gating deficit have reduced hippocampal expression of the {alpha}7 subunit. We have cloned and sequenced the full length cDNA for the mouse {alpha}7 gene (Acra-7) and characterized its gene structure. The murine {alpha}7 shares amino acid identity of 99% and 93% with the rat and human {alpha}7 subunits, respectively. Using an interspecies backcross panel, the ...

1994-09-01

388

Structure-function studies on inhibitory activity of Bungarus multicinctus protease inhibitor-like protein on matrix metalloprotease-2, and invasion and migration of human neuroblastoma SK-N-SH cells.

Metagenomics projects based on shotgun sequencing of populations of micro-organisms yield insight into protein families. We used sequence similarity clustering to explore proteins with a comprehensive dataset consisting of sequences from available databases together with 6.12 million proteins predicted from an assembly of 7.7 million Global Ocean Sampling (GOS) sequences. The GOS dataset covers nearly all known prokaryotic protein families. A total of 3,995 medium- and large-sized clusters consisting of only GOS sequences are identified, out of which 1,700 have no detectable homology to known families. The GOS-only clusters contain a higher than expected proportion of sequences of viral origin, thus reflecting a poor sampling of viral diversity until now. Protein domain distributions in the GOS dataset and current protein databases show distinct biases. Several protein domains that were previously categorized as kingdom specific are shown to ...

2006-03-23

389

Structural analysis of covalently labeled estrogen receptors by limited proteolysis and monoclonal antibody reactivity

In view of the findings that several Kunitz-type protein inhibitors suppress tumor invasion and metastasis, the aim of the present study is to explore whether Bungarus multicinctus protease inhibitor-like protein-2 (PILP-2) and PILP-3 exhibit anti-tumor activity. Although approximately 28% of amino acid substitutions occurred between PILP-2 and PILP-3, molecular modeling suggested that PILP-2 and PILP-3 shared similar folded structures. Unlike PILP-2, PILP-3 showed a notable activity in abolishing migration and invasion of human neuroblastoma SK-N-SH cells. The ability of PILP-3 to inhibit matrix metalloprotease-2 (MMP-2) activity was higher than that of PILP-2. Pull-down assay revealed protein-protein interaction between PILP-3 and MMP-2. In contrast to mutation on N-terminal region, replacement of amino acids at C-terminus attenuated notably the ability of PILP-3 to inhibit cell invasion, cell migration and MMP-2 activity as well as the binding capability of PILP-3 with MMP-2. ...

2009-08-23

390

Spectral properties of cylindrical quasioptical cavity resonator with random inhomogeneous side boundary.

The authors have used limited proteolysis of affinity-labeled estrogen receptors (ER), coupled with antireceptor antibody immunoreactivity, to assess structural features of ER and the relatedness of ER from MCF-7 human breast cancer and rat uterine cells. MCF-7 ER preparations covalently labeled with ["3H]tamoxifen aziridine (["3H]TAZ) were treated with trypsin (T), #alpha#-chymotrypsin (C), or Staphylococcus aureus V8 protease prior to electrophoresis on sodium dodecyl sulfate gels. Fluorography revealed a distinctive ladder of ER fragments containing TAZ for each protease generated from the M/sub r/ 66,000 ER. Immunoblot detection with the primate-specific antibody D75P3#gamma# revealed that all immunoreactive fragments corresponded to TAZ-labeled fragments but that some small TAZ-labeled fragments were no longer immunoreactive. In contrast, use of the antibody H222SP#gamma# revealed a correspondence between TAZ-labeled and immunoreactive fragments down to the smallest fragments ...

391

STOMP, Subsurface Transport Over Multiple Phases, theory guide

A rigorous solution for the spectrum of a quasioptical cylindrical cavity resonator with a randomly rough side boundary has been obtained. To accomplish this task, we have developed a method for the separation of variables in a wave equation, which enables one, in principle, to rigorously examine any limiting case-from negligibly weak to arbitrarily strong disorder at the resonator boundary. It is shown that the effect of disorder-induced scattering can be properly described in terms of two geometric potentials, specifically, the "amplitude" and the "gradient" potentials, which appear in wave equations in the course of conformal smoothing of the resonator boundaries. The scattering resulting from the gradient potential appears to be dominant, and its impact on the whole spectrum is governed by the unique sharpness parameter ?, the mean tangent of the asperity slope. As opposed to the resonator with bulk disorder, the distribution of nearest-neighbor spacings (NNS) in the ...

2011-08-30

392

Platelet receptor recognition domain on the. gamma. chain of human fibrinogen and its synthetic peptide analogues

This guide describes the simulator`s governing equations, constitutive functions and numerical solution algorithms of the STOMP (Subsurface Transport Over Multiple Phases) simulator, a scientific tool for analyzing multiple phase subsurface flow and transport. The STOMP simulator`s fundamental purpose is to produce numerical predictions of thermal and hydrologic flow and transport phenomena in variably saturated subsurface environments, which are contaminated with volatile or nonvolatile organic compounds. Auxiliary applications include numerical predictions of solute transport processes including radioactive chain decay processes. In writing these guides for the STOMP simulator, the authors have assumed that the reader comprehends concepts and theories associated with multiple-phase hydrology, heat transfer, thermodynamics, radioactive chain decay, and nonhysteretic relative permeability, saturation-capillary pressure constitutive functions. The authors further assume that the reader ...

1996-10-01

393

On the calculation of scattered fields by 3-D structure in the time-domain electromagnetic (TDEM) method; Jikan ryoiki denjiho ni okeru sanjigen kozo kara no sanranba no keisan ni tsuite

The authors have shown previously that the domain recognizing receptors on activated human platelets is located on the human fibrinogen {gamma} chain between residues 400 and 411. To study the correlation between the structure of this segment of the {gamma} chain and its reactivity toward receptors on ADP-activated human platelets, they designed a series of analogues containing replacements at 9 out of 12 positions. A double substitution of the normal His{sup 400}-His{sup 401} sequence by Ala-Ala reduced the inhibitory potency of the dodecapeptide 3-fold. When Lys{sup 406} was replaced by Arg, the inhibitory potency of the dodecapeptide decreased 15 times. On the other hand, substitution of Ala{sup 408} with Arg increased the inhibitory potency of the dodecapeptide 6-fold. A drastic decrease in the reactivity of the dodecapeptide toward platelet receptors was observed when Val{sup 411} was replaced by leucine or cysteine or tyrosine. A 3-fold decrease in reactivity ...

1989-04-04

394

Numerical study of the impingement of a supersonic, axisymmetric jet on a flat plate

This paper describes the calculation method of 3-D underground structures in TDME method which measures only field components. Recently, FDTD method was developed as calculation method in time domain difference calculus, and the forward analysis accuracy of 3-D fields was rapidly improved. The survey results using a large-scale loop (600m{times}360m) were numerically analyzed by FDTD method. 16 measuring lines were prepared in both X and Y directions, and measuring points were prepared on intersection points of the measuring lines. Since signal current is staircase one, step and impulse responses of the ground were determined by calculating magnetic field and its time differentiation. The rectangular body (120m{times}120m{times}100m) of 0.2S/m in conductivity (5 ohm m in resistivity) was installed 160m under the ground as 3-D resistivity anomaly. The ground of 0.01S/m (100 ohm m) was assumed. Time variation in horizontal magnetic field vector plot of impulse ...

1996-10-01

395

Joint Thesaurus. Part I (A-L) + Part II (M-Z)

A numerical method for studying the flow field of an under-expanded axis-symmetric jet created by a converging-diverging nozzle and impinging on a flat plate is presented. The calculation domain of interest is a region that contains all the features of the jet that leaves the nozzle and impinges onto the plate. Axial symmetry of the domain allows a reduced 2-dimensional model to be used. FLUENT software is utilized to solve the continuity, momentum and energy equations using a coupled implicit scheme. The ideal-gas law is used to determine the gas density along with a k-#epsilon# turbulence model with a special modification to account for compressibility effects. In addition, the temperature dependency of viscosity has been taken into consideration. A number of different modeling techniques are investigated including different approximations to account for the flow inside the nozzle. Performance of non-equilibrium wall functions for near-wall ...

396

Integrated design environment for human performance and human reliability analysis

This is the 1st revision of the INIS/ETDE Joint Thesaurus. It contains 20 953 valid descriptors and 8 600 forbidden terms. It was last updated in December 2003. The Joint Thesaurus contains the controlled terminology for indexing all information within the subject scope of both INIS (International Nuclear Information System) and ETDE (Energy Technology Data Exchange) information systems. The terminology is intended for use in subject description for input or retrieval of information in those systems. The thesaurus is a terminological control device used in translating from the natural language of documents, indexers or users into a more constrained system language It is also a controlled and dynamic vocabulary of semantically and generically related terms which covers a specific domain of knowledge. The domain of knowledge covered by this Thesaurus includes physics (in particular, plasma physics, atomic and molecular physics, and especially ...

1998-05-01

397

Influence of the fin orientation on the cooling of disc-brakes

Work over the last few years at the Idaho National Engineering and Environmental Laboratory (INEEL) has included a major focus on applying human performance and human reliability knowledge and methods as an integral element of system design and development. This work has been pursued in programs in a wide variety of technical domains, beginning with nuclear power plant operations. Since the mid-1980`s the laboratory has transferred the methods and tools developed in the nuclear domain to military weapons systems and aircraft, offshore oil and shipping operations, and commercial aviation operations and aircraft design. Through these diverse applications the laboratory has developed an integrated approach and framework for application of human performance analysis, human reliability analysis (HRA), operational data analysis, and simulation studies of human performance to the design and development of complex systems. This approach was recently ...

1997-05-01

398

Ectopic expression of a COOH-terminal fragment of the human telomerase reverse transcriptase leads to telomere dysfunction and reduction of growth and tumorigenicity in HeLa cells.

Nowadays, computational fluid dynamics is being applied in many fronts to improve the understanding of the flow and heat transfer behaviour in engineering applications. Unfortunately, there are not so many computational investigations regarding the ventilation and temperature distribution in discs-brakes. In this respect, this study presents a (CFD) analysis is carried out to investigate temperature distributions and flow patterns through disc brakes. The final goal is the development of shapes that optimize heat dissipation rates dictating the stopping capability of disc brakes. High performance discs brakes have a variety of cooling channels and the optimization of these passages is a challenging task for the manufacturing industry. High values of heat transfer coefficients of disc-brake configurations, are the most critical quantities during the design phase of new braking systems. In this context, a parametric study of the influence of the fin orientation concerning the cooling ...

2003-05-28

399

Distributed Data Integration Infrastructure

The COOH-terminus of telomerase reverse transcriptase (hTERT) has been shown to participatein the nuclear translocation of TERT. Here, we constructed plasmids expressing the COOH-terminal M(r) 27,000 polypeptide of hTERT (hTERTC27) withthe telomerase RNA-binding domains and the reverse transcriptase domains deleted. We showed that ectopic overexpression of this polypeptide caused a defect in telomere maintenance in hTERT-positive HeLa cells, which led to senescence-like growth arrest and apoptosis. The hTERTC27 appears to work by inducing telomere dysfunction, exemplified by significantly increased anaphase chromosome end-to-end fusion events in transfected cells. Significantly, it had no effect on the cellular telomerase enzymatic activity or telomere length. The in vivo effect was further demonstrated as HeLa cells stably expressing hTERTC27 have significantly lower growth rate and reduced tumorigenicity in nude mice xenografts. Results from ...

2002-06-01

400

Development of an efficient parallel FEM analysis program for large structural problems over several millions of DOF

The Internet is becoming the preferred method for disseminating scientific data from a variety of disciplines. This can result in information overload on the part of the scientists, who are unable to query all of the relevant sources, even if they knew where to find them, what they contained, how to interact with them, and how to interpret the results. A related issue is keeping up with current trends in information technology often taxes the end-user's expertise and time. Thus instead of benefiting from this information rich environment, scientists become experts on a small number of sources and technologies, use them almost exclusively, and develop a resistance to innovations that can enhance their productivity. Enabling information based scientific advances, in domains such as functional genomics, requires fully utilizing all available information and the latest technologies. In order to address this problem we are developing a end-user centric, ...

2003-02-24

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

401

Designed hybrid TPR peptide targeting Hsp90 as a novel anticancer agent

In order to predict or to evaluate the structural reliability of a variety of nuclear components under actual changing operating conditions, it is necessary to take the detailed geometrical features of components into consideration on one hand, and thermo-mechanical loading conditions with space and time variations during the lifetime, on the other hand. This consideration leads the authors to develop a super large-scale structural analysis program based on a parallel computational FEM with a variable scale of PC cluster architecture, whose prototype system is presented in a companion paper in this Symposium. Development of the PC cluster technology is one of the most important subjects in large-scale structural simulation, reducing computer costs and thus making simulation more acceptable to the engineering community. This paper presents the developmental status of the parallel FEM solver, demonstrating computational capabilities with three dimensional effects taking into ...

2000-09-01

402

Deploying perfSONAR-based End-2-End monitoring for production US CMS networking

BackgroundDespite an ever-improving understanding of the molecular biology of cancer, the treatment of most cancers has not changed dramatically in the past three decades and drugs that do not discriminate between tumor cells and normal tissues remain the mainstays of anticancer therapy. Since Hsp90 is typically involved in cell proliferation and survival, this is thought to play a key role in cancer, and Hsp90 has attracted considerable interest in recent years as a potential therapeutic target.MethodsWe focused on the interaction of Hsp90 with its cofactor protein p60/Hop, and engineered a cell-permeable peptidomimetic, termed "hybrid Antp-TPR peptide", modeled on the binding interface between the molecular chaperone Hsp90 and the TPR2A domain of Hop.ResultsIt was demonstrated that this designed hybrid Antp-TPR peptide inhibited the interaction of Hsp90 with the TPR2A domain, inducing cell death of breast, pancreatic, renal, lung, prostate, ...

2011-01-14

403

Composing simulations using persistent software components

Fermilab is the US Tier-1 Center for CMS data storage and analysis. End-2-End (E2E) circuits are utilized to support high impact data movement into and out of the Tier-1 Center. E2E circuits have been implemented to facilitate the movement of raw experiment data from the Tier-0 Center at CERN, as well as processed data to a number of the US Tier-2 sites. Troubleshooting and monitoring of those circuits presents a significant challenge, since the circuits typically cross multiple research & education networks, each with its own management domain and customized monitoring capabilities. The perfSONAR Monitoring Project was established to facilitate development and deployment of a common monitoring infrastructure across multiple network management domains. Fermilab has deployed perfSONAR across its E2E circuit infrastructure and enhanced the product with several tools that ease the monitoring and management of those circuits. This paper will ...

2007-09-01

404

Choosing the Right Solution Approach: The Crucial Role of Situational Knowledge in Electricity and Magnetism

The traditional process for developing large-scale simulations is cumbersome, time consuming, costly, and in some cases, inadequate. The topics of software components and component-based software engineering are being explored by software professionals in academic and industrial settings. A component is a well-delineated, relatively independent, and replaceable part of a software system that performs a specific function. Many researchers have addressed the potential to derive a component-based approach to simulations in general, and a few have focused on military simulations in particular. In a component-based approach, functional or logical blocks of the simulation entities are represented as coherent collections of components satisfying explicitly defined interface requirements. A simulation is a top-level aggregate comprised of a collection of components that interact with each other in the context of a simulated environment. A component may represent a simulation artifact, an ...

1999-03-01

405

Chlorophyll assembled electrode for photovoltaic conversion device

Novice problem solvers are rather sensitive to surface problem features, and they often resort to trial and error formula matching rather than identifying an appropriate solution approach. These observations have been interpreted to imply that novices structure their knowledge according to surface features rather than according to problem type categories. However, it may also be the case that novices do know problem types, but cannot map the problem at hand to a known type, because they fail to create a sufficiently well-elaborated problem representation. This study aims to distinguish between these explanations. In this study novice physics students at high and low levels of proficiency completed two problem-sorting tasks from the domain of electricity and magnetism, one with and one without elaboration support. Results confirm that these students do distinguish problem types in accordance with their required solution approaches, and that their problem-sorting ...

2010-12-01

406

Adaptive meshing technique applied to an orthopaedic finite element contact problem.

Chlorophyll-a (Chl-a) assembled in hydrophobic domain by fatty acid with long alkyl hydrocarbon chain such as myristic acid (Myr), stearic acid (Ste) and cholic acid (Cho) modified onto nanocrystalline TiO{sub 2} electrode is prepared and the photovoltaic properties of the nanocrystalline TiO{sub 2} film by Chl-a are studied. Incident photon to current efficiency (IPCE) value at 660 nm in photocurrent action spectrum of Chl-a/Ste-TiO{sub 2}, Chl-a/Myr-TiO{sub 2} and Chl-a/Cho-TiO{sub 2} electrodes are 5.0%, 4.1% and 4.1%, respectively. Thus, the IPCE is maximum using Chl-a/Ste-TiO{sub 2} electrode. From the results of photocurrent responses with light intensity of 100 mW cm{sup -2} irradiation or monochromatic light with 660 nm, generated photocurrent increases using Chl-a/Ste-TiO{sub 2} electrode compared with the other Chl-a assembled TiO{sub 2} electrodes. These results show that the hydrophobic domain formed by stearic acid with long alkyl ...

2007-11-20

407

ATRX ADD domain links an atypical histone methylation recognition mechanism to human mental-retardation syndrome

Finite element methods have been applied extensively and with much success in the analysis of orthopaedic implants. Recently a growing interest has developed, in the orthopaedic biomechanics community, in how numerical models can be constructed for the optimal solution of problems in contact mechanics. New developments in this area are of paramount importance in the design of improved implants for orthopaedic surgery. Finite element and other computational techniques are widely applied in the analysis and design of hip and knee implants, with additional joints (ankle, shoulder, wrist) attracting increased attention. The objective of this investigation was to develop a simplified adaptive meshing scheme to facilitate the finite element analysis of a dual-curvature total wrist implant. Using currently available software, the analyst has great flexibility in mesh generation, but must prescribe element sizes and refinement schemes throughout the domain of interest. ...

2004-01-01

408

ATP-dependent partitioning of the DNA template into supercoiled domains by Escherichia coli UvrAB

ATR-X (alpha-thalassemia/mental retardation, X-linked) syndrome is a human congenital disorder that causes severe intellectual disabilities. Mutations in the ATRX gene, which encodes an ATP-dependent chromatin-remodeler, are responsible for the syndrome. Approximately 50% of the missense mutations in affected persons are clustered in a cysteine-rich domain termed ADD (ATRX-DNMT3-DNMT3L, ADD{sub ATRX}), whose function has remained elusive. Here we identify ADD{sub ATRX} as a previously unknown histone H3-binding module, whose binding is promoted by lysine 9 trimethylation (H3K9me3) but inhibited by lysine 4 trimethylation (H3K4me3). The cocrystal structure of ADD{sub ATRX} bound to H3{sub 1-15}K9me3 peptide reveals an atypical composite H3K9me3-binding pocket, which is distinct from the conventional trimethyllysine-binding aromatic cage. Notably, H3K9me3-pocket mutants and ATR-X syndrome mutants are defective in both H3K9me3 binding and localization at ...

2011-07-19

409

A single amino acid substitution (R441A) in the receptor-binding domain of SARS coronavirus spike protein disrupts the antigenic structure and binding activity

The helicase action of the Escherichia coli UvrAB complex on a covalently closed circular DNA template was monitored using bacterial DNA topoisomerase I, which specifically removes negative supercoils. In the presence of E. coli DNA topoisomerase I and ATP, the UvrAB complex gradually introduced positive supercoils into the input relaxed plasmid DNA template. Positive supercoils were not produced when E. coli DNA topoisomerase I was replaced by eukaryotic DNA topoisomerase I or when both E. coli and eukaryotic DNA topoisomerases I were added simultaneously. These results suggest that like other DNA helix-tracking processes, the ATP-dependent action of the UvrAM complex on duplex DNA simultaneously generates both positive and negative supercoils, which are not constrained by protein binding but are torsionally strained. The supercoiling activity of UvrAB on UV-damaged DNA was also studied using UV-damaged plasmid DNA and a mutant UvrA protein that lacks the 40 C-terminal amino acids and ...

410

3-D depth migration: various methods and how they perform on real data

The spike (S) protein of severe acute respiratory syndrome coronavirus (SARS-CoV) has two major functions: interacting with the receptor to mediate virus entry and inducing protective immunity. Coincidently, the receptor-binding domain (RBD, residues 318-510) of SAR-CoV S protein is a major antigenic site to induce neutralizing antibodies. Here, we used RBD-Fc, a fusion protein containing the RBD and human IgG1 Fc, as a model in the studies and found that a single amino acid substitution in the RBD (R441A) could abolish the immunogenicity of RBD to induce neutralizing antibodies in immunized mice and rabbits. With a panel of anti-RBD mAbs as probes, we observed that R441A substitution was able to disrupt the majority of neutralizing epitopes in the RBD, suggesting that this residue is critical for the antigenic structure responsible for inducing protective immune responses. We also demonstrated that the RBD-Fc bearing R441A mutation could not bind to soluble and ...

2006-05-26

411

Which neuro-physiologic effects at low level 2.45 GHz RF exposure?; Quels effets neurophysiologiques pour un champ electromagnetique de faible puissance a 2,45 GHz?

3-D depth migration is one of the most active areas of research and development and it has been approached from different angles. An accurate algorithm which works in the space-frequency domain was introduced by Blacquiere et al. (1989). Unfortunately, it is computationally very expensive and not suitable for solving real-life 3-D migration problems. This led to the development of an alternative scheme (hale, 1990) which sacrifices some accuracy but is much more efficient. It is commonly referred to as the Hale-McClellan method. An alternative procedure known as reverse-time migration works in the space-time domain. It is based on the full wave equation and yields by far the most accurate results, but it requires extremely large computer resources. However, a series of new developments (Mufti et al, 1996) have made this algorithm a very practical tool even for migrating large exploration-scale 3-D real data. We shall provide a comparative ...

1997-07-01

412

Unsaturated zone flow modeling for GWTT-95

The LS electromagnetic band (1-4 GHz) is widely used both in domestic and industrial domains. Several studies suggested that the biological systems would exhibit a specific sensitivity to the 2.45 GHz microwaves (water resonance frequency). Potential human health hazards and especially a disruption of the cholinergic system have been reported, due to exposure to microwaves even at low power density. This work presents a multi-parametric study of freely moving rat where neuro-physiology was investigated during 70 hours using neurochemical (micro-dialysis technique), electrophysiological, behavioral (vigilance stages quantification) and thermo-physiological approaches. The rats were exposed 24 hours to a 2.45 GHz pulsed electromagnetic field at low power density. In this exposure conditions, no significant effect have been reported. (authors)

2007-06-15

413

Time contour expression of limited range phenomena on stack chart; Jugo chart jo deno kyokuchi gensho jikan contour

In accordance with the Nuclear Regulatory Commission regulation regarding groundwater travel times at geologic repositories, various models of unsaturated flow in fractured tuff have been developed and implemented to assess groundwater travel times at the potential repository at Yucca Mountain, Nevada. Kaplan used one-dimensional models to describe the uncertainty and sensitivity of travel times to various processes at Yucca Mountain. Robey and Arnold et al. used a two-dimensional equivalent continuum model (ECM) with inter- and intra-unit heterogeneity in an attempt to assess fast-flow paths through the unsaturated, fractured tuff at Yucca Mountain (GWTT-94). However, significant flow through the fractures in previous models was not simulated due to the characteristics of the ECM, which requires the matrix to be nearly saturated before flow through the fractures is initiated. In the current study (GWTT-95), four two-dimensional cross-sections at Yucca Mountain are simulated using both ...

1995-12-31

414

Three-dimensional power system stabilizer

Time contour expression of limited range phenomena on stack chart is examined for further improvement on the result of the ultimate interpretation in the seismic reflection survey. The policy is made clear from the beginning that local phenomena are to be discussed, and data prior CMP stacking is interpreted in detail. For this purpose, it is effective to make use of the time contour expression in the midpoint-offset plane simultaneously with the CMP and COP panels. For the review of data prior to CMP stacking, it is convenient to use the CMP (CDP) stacking chart in which the data is arranged methodically. In this chart, all the channels which are crude data prior to stacking are plotted on midpoint-offset coordinates, which plane is called the MOD (Midpoint Offset Domain) panel. Various panels can be chosen unrestrictedly, and their mutual relations can be easily grasped. When data points are given a time axis, they can be expressed in a time contour. Studies are ...

1997-05-27

415

Three dimensional wavefield modeling using the pseudospectral method; Pseudospectral ho ni yoru sanjigen hadoba modeling

Power system stabilizers (PSSs) are used to enhance damping of power system oscillations through excitation control of synchronous generator. The objective of the PSS is to generate a stabilizing signal, which produces a damping torque component on the generator shaft. Conventional PSSs are designed with the phase compensation technique in the frequency domain and include the lead-lag blocks whose parameters are determined according to a linearized power system model. The performance of conventional PSSs (CPSSs) depends upon the generator operating point and the system parameters, but a reasonable level of robustness can be achieved depending on the tuning method. This paper presents a new three-dimensional PSS (3D PSS), which uses rotor speed deviation, rotor acceleration and load angle deviation as input signals. The 3D PSS attempts to return the generator to the state-space origin, based on the generator's trajectory in state-space and the achievement ...

2010-07-15

416

The uranium deposits of Ontario

Discussed in this report is a wavefield simulation in the 3-dimensional seismic survey. With the level of the object of exploration growing deeper and the object more complicated in structure, the survey method is now turning 3-dimensional. There are several modelling methods for numerical calculation of 3-dimensional wavefields, such as the difference method, pseudospectral method, and the like, all of which demand an exorbitantly large memory and long calculation time, and are costly. Such methods have of late become feasible, however, thanks to the advent of the parallel computer. As compared with the difference method, the pseudospectral method requires a smaller computer memory and shorter computation time, and is more flexible in accepting models. It outputs the result in fullwave just like the difference method, and does not cause wavefield numerical variance. As the computation platform, the parallel computer nCUBE-2S is used. The object domain is divided ...

1997-05-27

417

The structure of myostatin:follistatin 288: insights into receptor utilization and heparin binding

The principal types of uranium deposits in Ontario are carbonatites and fenites, alkalic volcanic rocks, pegiatites, calc-silicate rocks, pyritic quartz-pebble conglomerates, polymictic conglomerates and some pelitic rocks, and various 'pitchblende' deposits including late Precambrian unconformities, possibly late Precambrian diabase dikes, and other unconformities: carbonates, sandstones, lignites, and semi-pelitic rocks of middle and upper Precambrian age. Only red unzoned pegmatite and the pyritic quartz-pebble conglomerate have supported production. Ontario reasonably assured and estimated resources in the economic and subeconomic categories in 1977 amounted to 553 000 tonnes U, and 1977 production was 4000 tonnes U. Measured, indicated, and inferred resources in the Elliot Lake - Agnew Lake area are at least 400 000 tonnes U. The latter deposits are also a significant thorium resource. Geological features reflecting major changes in physics and chemistry are prime controls on ...

1990-03-15

418

The neuroimmune-endocrine axis: pathophysiological implications for the central nervous system cytokines and hypothalamus-pituitary-adrenal hormone dynamics

Myostatin is a member of the transforming growth factor-{beta} (TGF-{beta}) family and a strong negative regulator of muscle growth. Here, we present the crystal structure of myostatin in complex with the antagonist follistatin 288 (Fst288). We find that the prehelix region of myostatin very closely resembles that of TGF-{beta} class members and that this region alone can be swapped into activin A to confer signalling through the non-canonical type I receptor Alk5. Furthermore, the N-terminal domain of Fst288 undergoes conformational rearrangements to bind myostatin and likely acts as a site of specificity for the antagonist. In addition, a unique continuous electropositive surface is created when myostatin binds Fst288, which significantly increases the affinity for heparin. This translates into stronger interactions with the cell surface and enhanced myostatin degradation in the presence of either Fst288 or Fst315. Overall, we have identified several ...

2009-09-29

419

Scientific Electronic Library Online (English)

Abstract in english Cytokines are molecules that were initially discovered in the immune system as mediators of communication between various types of immune cells. However, it soon became evident that cytokines exert profound effects on key functions of the central nervous system, such as food intake, fever, neuroendocrine regulation, long-term potentiation, and behavior. In the 80's and 90's our group and others discovered that the genes encoding various cytokines and their receptors are e (more) xpressed in vascular, glial, and neuronal structures of the adult brain. Most cytokines act through cell surface receptors that have one transmembrane domain and which transduce a signal through the JAK/STAT pathway. Of particular physiological and pathophysiological relevance is the fact that cytokines are potent regulators of hypothalamic neuropeptidergic systems that maintain neuroendocrine homeostasis and which regulate the body's response to stress. The mechanisms ...

2000-10-01

420

The influence of a seed crystal on the texture of a bulk YBaCuO specimen

The frequency map for billiards inside ellipsoids

To investigate the dependence of the local texture of parts of an YBaCuO specimen on the distance of the seed crystal from the position of the part of the specimen, a very good textured YBaCuO specimen was cut into 9 rectangular pieces and into 12 boundary pieces of the cylindric original specimen. From the individual parts of the YBaCuO specimen the texture was measured by neutron diffraction at the Geesthacht reactor with an equal area raster. The grid width was 1 up to 10 deviation from the cylinder axis of the original YBaCuO cylinder and 2 from 10 deviation until 20 deviation. From the sum of the counted neutrons on small circles on the pole sphere the individual values of the distributions of the angular deviations of the c-axes of the crystalline domains from the cylinder axis have been calculated. The mean deviation of the c-axes from the axis of the original cylinder increases from the inner part with the seed crystal to the boundary parts of the cylindric ...

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

421

The cosmic-ray antiproton spectrum between 0. 1 and 1. 5 GeV kinetic energy

The billiard motion inside an ellipsoid $Q \\subset \\Rset^{n+1}$ is completely integrable. Its phase space is a symplectic manifold of dimension $2n$, which is mostly foliated with Liouville tori of dimension $n$. The motion on each Liouville torus becomes just a parallel translation with some frequency $\\omega$ that varies with the torus. Besides, any billiard trajectory inside $Q$ is tangent to $n$ caustics $Q_{\\lambda_1},...,Q_{\\lambda_n}$, so the caustic parameters $\\lambda=(\\lambda_1,...,\\lambda_n)$ are integrals of the billiard map. The frequency map $\\lambda \\mapsto \\omega$ is a key tool to understand the structure of periodic billiard trajectories. In principle, it is well-defined only for nonsingular values of the caustic parameters. We present four conjectures, fully supported by numerical experiments. The last one gives rise to some lower bounds on the periods. These bounds only depend on the type of the caustics. We describe the geometric meaning, ...

2010-01-01

422

The Origin of Life from Primordial Planets

In the summer of 1980, a balloon-borne cosmic ray experiment reported the detection of 14 low energy antiprotons during an 18 hour flight. This measurement represented an antiproton intensity two orders of magnitude greater than that predicted by conventional theories. This surprising result triggered a flurry of papers theorizing the origin of these particles, including the prediction of domains of primary antimatter, and evidence for supersymmetric particle annihilation. Not until the summer of 1987 was a follow up experiment (PBAR) performed. The PBAR detector has both better resolution and a larger dynamic range in energy than the previous detector. It measured the energy spectrum of antiprotons in the 0.1-1.5 GeV kinetic energy range. The present work describes the instrument, the experiment, and the results. Our analysis of the PBAR data reveals no antiprotons in the energy range of 0.13-0.64 GeV and only one antiproton candidate for energies between 0.64 and ...

1988-01-01

423

Thai Family Health Routines: scale development and psychometric testing.

The origin of life and the origin of the universe represent two of the most important problems of science. Both are resolved by hydro-gravitational dynamics (HGD) cosmology (Gibson 1996, Schild 1996, Gibson 2009ab), which predicts frozen primordial hydrogen-helium gas planets in clumps as the dark matter of galaxies. Merging Earth-mass planets formed stars, moons and comets to incubate and cosmically seed the first life. Cometary panspermia (Hoyle and Wickramasinghe 1981, 1982; Wickramasinghe et al. 2009) occurs naturally by HGD mechanisms. Comets and moons are fragments from mergers of stardust covered frozen gas planets in their step-wise growth to star mass. Supernovae from stellar over-accretion of planets produce stardust (C, N, O, P etc.) chemical fertilizer. Planets collect this infected radioactive dust gravitationally, to provide liquid water domains in contact with life nutrients seeded with life prototypes. The first mutating, evolving, life from HGD ...

2010-01-01

424

Technical Training Seminar

The aims of the study were to develop and test the psychometric properties of the Thai Family Health Routines (TFHR) scale, a 70-item self-report questionnaire used to measure the health of Thai families through their routine behaviors in daily life. Development of the TFHR was based on the structural domains of Denham's Family Health Model. The TFHR scale was initially composed of 85 items and tested on 1,040 families living in the central region of Thailand. The confirmatory factor analysis, with an acceptable factor structure model, yielded 70 items aligned with six factors: self-care, safety and prevention, mental health behavior, family care, family caregiving, and illness care routines. The preliminary psychometric properties demonstrated that the TFHR scale had satisfactory internal consistency, criterion validity, and construct validity. The test results suggested that the TFHR scale has potential benefits for family and community nurses to assess Thai ...

2009-05-01

425

Synthesis, structural activity-relationships, and biological evaluation of novel amide-based allosteric binding site antagonists in NR1A/NR2B N-methyl-d-aspartate receptors

Thursday 4 September From 14:00 to 17:00 - Training Centre Auditorium bldg. 593, room 11 The Summit Design VisualElite 4.0 Release Jean Marie St Paul / SUMMIT DESIGN, Europe, Technical Manager Michel Delcroix / SUMMIT DESIGN, Southern Europe, Sales F-95015 CERGY PONTOISE, France Summit Design is an important EDA digital hardware design tool supplier, and the industry leader in the emerging Electronic System Level design domain. Its VisualElite program has been used at CERN for several years. This seminar will include the highlights of the program's latest release. It will be illustrated how Summit Design products can provide a high-level C/C++ and SystemC functional modelling design and verification environment, enabling engineers to analyse system concepts before the implementation stage. The seminar will show how mixed SystemC and HDL simulation can be done, along with solutions for hardware/software development. • HDL new features: Connectivity ...

2003-01-01

426

British Library Electronic Table of Contents (United Kingdom)

The synthesis and structure-activity relationship analysis of a novel class of amide-based biaryl NR2B-selective NMDA receptor antagonists are presented. Some of the studied compounds are potent, selective, non-competitive, and voltage-independent antagonists of NR2B-containing NMDA receptors. Like the founding member of this class of antagonists (ifenprodil), several interesting compounds of the series bind to the amino terminal domain of the NR2B subunit to inhibit function. Analogue potency is modulated by linker length, flexibility, and hydrogen bonding opportunities. However, unlike previously described classes of NR2B-selective NMDA antagonists that exhibit off-target activity at a variety of monoamine receptors, the compounds described herein show much diminished effects against the...

2009-01-01

427

Study on the time-domain electromagnetic responses; TDEM ho ni okeru denji oto ni tsuite

Storage of hazardous substances in bonded warehouses

With an objective to perform three-dimensional analysis with high accuracy in using the electromagnetic exploration method, characteristics in electromagnetic response were analyzed, and conditions for acquiring necessary data were discussed. The discussion defined a parameter called `response anomaly` which uses response from media to standardize response only from substances with abnormal resistivity. The receivers were located uniformly on the same plane, and the response anomaly was derived from electromagnetic response from each of the three horizontal and vertical components at each receiving point, which was expressed as a contour map. The parameter for the abnormal body was consisted of location and resistivity contrast with media. Discussions using the contour map were given on the response when these factors for the parameter were varied. As a result, it was found that the response anomaly appears in the form that reflects the abnormal body, and the response anomaly of the ...

1997-05-27

428

Sorption of atrazine and phenanthrene by organic matter fractions in soil and sediment

A variety of special regulations exist in Costa Rica for registration and transport of hazardous substances; these set the requirements for entry into the country and the security of transport units. However, the regulations mentioned no specific rules for storing hazardous substances. Tax deposits have been the initial place where are stored the substances that enter the country.The creation of basic rules that would be regulating the storage of hazardous substances has taken place through the analysis of regulations and national and international laws governing hazardous substances. The regulatory domain that currently exists will be established with a field research in fiscal deposits in the metropolitan area. The storage and security measures that have been used by the personnel handling the substances will be identified to be putting the reality with that the hazardous substances have been handled in tax deposits. A rule base for the storage of hazardous ...

429

Soft X-ray holography of FIB nanostructured Co/Pt multilayers

Atrazine and phenanthrene (Phen) sorption by nonhydrolyzable carbon (NHC), black carbon (BC), humic acid (HA) and whole sediment and soil samples was examined. Atrazine sorption isotherms were nearly linear. The single-point organic carbon (OC)-normalized distribution coefficients (K_O_C) of atrazine for the isolated HA1, NHC1 and BC1 from sediment 1 (ST1) were 36, 550, and 1470 times greater than that of ST1, respectively, indicating the importance of sediment organic matter, particularly the condensed fractions (NHC and BC). Similar sorption capacity of atrazine and Phen by NHC but different isotherm nonlinearity indicated different sorption domains due to their different structure and hydrophobicity. The positive relationship between (O + N)/C ratios of NHC and atrazine log K_O_C at low concentration suggests H-bonding interactions. This study shows that sediment is probably a less effective sorbent for atrazine than Phen, implying that atrazine applied in ...

2010-12-01

430

Rotating magnetic tensor gradiometry and a superconducting implementation

Focused Ion Beam (FIB) milling is a powerful tool to produce ordered magnetic nanostructures. However, it is impossible to produce out-of-plane magnetized nanoscale structures from multilayer films by direct FIB writing. Co/Pt multilayers exhibit an out-of-plane easy axis due to strong perpendicular interface anisotropy. The interface contribution is known to be very sensitive to high energy ion irradiation. In case of 30 keV Ga ions it needs less than one ion per 100 surface atoms to destroy the perpendicular interface anisotropy. We demonstrate how this problem can be overcome by milling a Co/Pt multilayer, which has been deposited on a SiN membrane, from the rear side, through the SiN. The effect of the ions is determined as a function of applied dose utilizing the domain structure imaged by soft X-ray holography. When the magnetic material is removed we find only a very narrow range of destruction around the holes in contrast to the observations when milling ...

2009-03-22

431

Representation of uncertainty in computer vision using fuzzy sets

This work describes the theoretical basis for a new concept rotating magnetic tensor gradiometer. The rotating gradiometer consists of an approximately axial or transverse gradiometer which is made to rotate about a perpendicular axis so that the direction of sensitivity is continually changing. It is demonstrated for the first time that the rotation separates gradient components of progressively higher-order in the frequency domain and enables absolute-value measurements of all components of the first-order magnetic gradient tensor, even if the magnetic sensors comprising the gradiometer are intrinsically incapable of absolute-value detection. In addition, the rotating gradiometer concept has a number of other advantages: the gradiometer imbalance is no longer directly determined by the engineering precision, the DC and low-frequency performance of the instrument is not limited by the performance of the detectors in these respects, rotation at frequencies above ...

2009-07-01

432

Report on the present day situation and technical perspectives of renewable energies; Rapport sur l'etat actuel et les perspectives techniques des energies renouvelables

Uncertainty in computer vision can arise at various levels. It can occur in the low level in the raw sensor input, and extends all the way through intermediate and higher levels. Ideally, at any level where decisions are being made on the basis of previous processing steps, a computer vision system must have sufficient flexibility for representation of uncertainty in any of these levels. The input cue representation portion of a computer vision system should maintain the information content of the original input images, while at the same time allowing for uncertainty in the identification of attributes required by other parts of the system for decision making. Processes such as edge detection, segmentation, and shape matching yield results which could bias higher level decision making, unless some framework is defined for the representation of uncertainty in the context of fuzzy set theory where membership values associated with the fuzzy sets contain a consistent but not necessarily ...

1986-02-01

433

Reduction of nitrogen oxides (NO{sub x}) production in a liquid fuel-oil diffusion flame by acoustic excitation; Reduction de la production des oxydes d`azote (NO{sub x}) dans une flamme de diffusion a fioul liquide par excitation acoustique

This work, carried out by the parliamentary office for the evaluation of scientific and technological choices on request of the French National Assembly and Senate, takes stock of the present day situation and technical perspectives of development of renewable energy sources and of research needs of the French industry in this domain: 1 - renewable energies: key-technologies for the energy supply of developing countries and for a rational consumption in transportation systems and accommodations of developed countries (energies technically different from fossil or nuclear energies; fundamental energy sources for a developing world; different national goals in Europe depending on the available natural resources and on the political realities; a minor interest in France for the domestic power generation but a major interest for transports, residential and tertiary sectors and export); 2 - priority choices given to the French renewable energy resources: renewable ...

2001-11-01

434

Real Paley-Wiener theorems and local spectral radius formulas

The control of nitrogen oxides (NO{sub x}) emissions will become a major challenge in the forthcoming years, in the domain of automotive industry or industrial burners. Pulsed combustion offers an imaginative solution which does not affect the combustion efficiency. In this paper, the efficiency of this method is demonstrated using the burner of a 20 kW domestic boiler. The actuator is simply installed on the air intake. Two types of actuators have been tested successfully: a loudspeaker and a rotative valve. Both can produce 100 to 1000 Hz frequencies and can lead to a reduction of 20% of NO{sub x} emissions. The feasibility of the concept is also demonstrated on a 840 kW liquid fuel-oil burner. The mechanisms involved during an excitation are explained using the CH{sup *} radical imaging. Results show an important reorganization of the flow and of the flame structure. During each excitation cycle, an annular swirl occurs at the leading edge of the flame catching ...

1996-12-31

435

Quantum thermodynamics. Emergence of thermodynamic behavior within composite quantum systems. 2. ed.

We systematically develop real Paley-Wiener theory for the Fourier transform on R^d for Schwartz functions, L^p-functions and distributions, in an elementary treatment based on the inversion theorem. As an application, we show how versions of classical Paley-Wiener theorems can be derived from the real ones via an approach which does not involve domain shifting and which may be put to good use for other transforms of Fourier type as well. An explanation is also given why the easily applied classical Paley-Wiener theorems are unlikely to be able to yield information about the support of a function or distribution which is more precise than giving its convex hull, whereas real Paley-Wiener theorems can be used to reconstruct the support precisely, albeit at the cost of combinatorial complexity. We indicate a possible application of real Paley-Wiener theory to partial differential equations in this vein and furthermore we give evidence that a number of real ...

2008-01-01

436

Proteomic analysis of the shistosome tegument and its surface membranes

This introductory text treats thermodynamics as an incomplete description of quantum systems with many degrees of freedom. Its main goal is to show that the approach to equilibrium -with equilibrium characterized by maximum ignorance about the open system of interest- neither requires that many particles nor is the precise way of partitioning, relevant for the salient features of equilibrium and equilibration. Furthermore, the text depicts that it is indeed quantum effects that are at work in bringing about thermodynamic behavior of modest-sized open systems, thus making Von Neumann's concept of entropy appear much more widely useful than sometimes feared, far beyond truly macroscopic systems in equilibrium. This significantly revised and expanded second edition pays more attention to the growing number of applications, especially non-equilibrium phenomena and thermodynamic processes of the nano-domain. In addition, to improve readability and reduce unneeded ...

437

Scientific Electronic Library Online (English)

Abstract in english The tegument surface of the adult schistosome, bounded by a normal plasma membrane overlain by a secreted membranocalyx, holds the key to understanding how schistosomes evade host immune responses. Recent advances in mass spectrometry (MS), and the sequencing of the Schistosoma mansoni transcriptome/genome, have facilitated schistosome proteomics. We detached the tegument from the worm body and enriched its surface membranes by differential extraction, before subjecting t (more) he preparation to liquid chromatography-based proteomics to identify its constituents. The most exposed proteins on live worms were labelled with impearmeant biotinylation reagents, and we also developed methods to isolate the membranocalyx for analysis. We identified transporters for sugars, amino acids, inorganic ions and water, which confirm the importance of the tegument plasma membrane in nutrient acquisition and solute balance. Enzymes, including phosphohydrolases, esterases and ...

2006-10-01

438

Photoluminescence linewidths in metalorganic vapor phase epitaxially grown ordered and disordered InAlGaP alloys

Phenomenology of a New Minimal Supersymmetric Extension of the Standard Model

The dependence of the photoluminescent properties of In_0_._4_8(Al_yGa_1_-_y)_0_._5_2P alloys (0#<=#y#<=#0.5) on growth temperature and substrate misorientation off GaAs(100) has been studied. Samples were grown using low-pressure metalorganic vapor phase epitaxy. By studying the dependence of ordering behavior in InGaP as a function of substrate misorientation and growth temperature simultaneously, a very large range in low-temperature photoluminescence emission energy---135 meV---has been obtained. The photoluminescence linewidth exhibits a strong, continuous dependence on the extent of atomic ordering (the emission energy) in the alloys. The results indicate that inhomogeneity in the microstructure of the material (i.e., between ''ordered'' domains and the ''disordered'' matrix) is the dominant photoluminescence broadening mechanism. This investigation has allowed a significant optimization of the optical properties of these materials, including the ...

439

Phenomenological Theory of the Kink Instability in a Slender Plasma Column

We study the phenomenology of a new Minimally-extended Supersymmetric Standard Model (newMSSM) where a gauge singlet superfield is added to the MSSM spectrum. The superpotential of this model contains no dimensionful parameters, thus solving the mu-problem of the MSSM. A global discrete R-symmetry, forbidding the cubic singlet self-interaction, imposed on the complete theory, guarantees its stability with respect to generated higher-order tadpoles of the singlet and solves both the domain wall and Peccei-Quinn axion problems. We give the free parameters of the model and display some general constraints on them. A particular attention is devoted to the neutralino sector where a (quasi-pure) singlino appears to be always the LSP of the model, leading to additional cascades, involving the NLSP -> LSP transition, compared with the MSSM. We then present the upper bounds on the masses of the lightest and next-to-lightest -- when the lightest is an invisible singlet -- ...

2001-01-01

440

Paul Scherrer Institute Scientific Report 1998. Volume IV: Nuclear Energy and Safety

When one deals with a plasma column whose radius a is much smaller than its length L, one can think of it as of a thin filament whose kink instability can be adequately described simply by a 2D displacement vector, {xi}{sub x} = {xi}{sub s}(z,t); {xi}{sub y} = {xi}{sub y}(z,t). Details of the internal structure of the column such as the current, density, and axial flow velocity distribution would be lumped into some phenomenological parameters. This approach is particularly efficient in the problems with non-ideal (sheath) boundary conditions (BC) at the end electrodes, with the finite plasma resistivity, and with a substantial axial flow. With the sheath BC imposed at one of the end-plates, we find instability in the domain well below the classical Kruskal-Shafranov limit. The presence of an axial flow causes the onset of rotation of the kink and strong axial ''skewness'' of the eigenfunction, with the perturbation amplitude ...

2005-11-18

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

441

Patched based methods for adaptive mesh refinement solutions of partial differential equations

Nuclear energy related research in Switzerland is concentrated at PSI`s Nuclear Energy and Safety Research Department (NES). The total effort invested in nuclear energy research in 1998 amounted to about 195 py/a and 4.5 millions CHF of investment and maintenance costs. Approximately half of the salary, investment and maintenance costs are externally funded, primarily by the Swiss Utilities, the national co-operative for the disposal of nuclear waste (NAGRA), the Federal Office of Energy (BFE) through the nuclear safety inspectorate (HSK) and the Federal Office for Science and Education (BBW) in connection with the EC Framework Programmes; an increasing part of external funding is coming from domestic and foreign industry (nuclear component and fuel suppliers). The activities of the department are concentrated on three main domains of: Safety and related problems of operating plants; safety features of future reactor and fuel cycles; waste management. 4 % of the ...

1999-09-01

442

Pancreatic endocrine tumours: an out-matching field of cooperation with nuclear medicine; Les tumeurs endocrines du pancreas: un domaine privilegie de la cooperation avec la medecine nucleaire

This manuscript contains the lecture notes for a course taught from July 7th through July 11th at the 1997 Numerical Analysis Summer School sponsored by C.E.A., I.N.R.I.A., and E.D.F. The subject area was chosen to support the general theme of that year`s school which is ``Multiscale Methods and Wavelets in Numerical Simulation.`` The first topic covered in these notes is a description of the problem domain. This coverage is limited to classical PDEs with a heavier emphasis on hyperbolic systems and constrained hyperbolic systems. The next topic is difference schemes. These schemes are the foundation for the adaptive methods. After the background material is covered, attention is focused on a simple patched based adaptive algorithm and its associated data structures for square grids and hyperbolic conservation laws. Embellishments include curvilinear meshes, embedded boundary and overset meshes. Next, several strategies for parallel implementations are examined. ...

1997-09-02

443

PDE-based Non-Linear Diffusion Techniques for Denoising Scientific and Industrial Images: An Empirical Study

The Zollinger-Ellison syndrome (ZES) is taken as an example of the diagnostic and therapeutic strategy in gastro-entero-pancreatic endocrine tumours, given the standard characteristics of this procedure, whatever the nature of the primitive tumour. Management of ZES includes: anatomical localization of gastrinoma and of possible metastases, in 60 % of cases this step conditioning therapeutic indications and chances of cure; search of a type 1-multiple endocrine neoplasia (MEN A), in 25 % of cases; therapeutic indications: ablative surgery with curative intent in case of gastrinoma and of resectable liver metastases, palliative treatment otherwise: anti-secretory drugs, somatostatin analogues, chemotherapy and interferon {alpha}; long-term follow-up of patients with resected tumour. At each step, somatostatin receptor scintigraphy with indium 111-pentetreotide does play a pivotal role. (author). 110 refs.

1996-12-31

444

Optical and electronic properties of Ag nanodots on Si(111)

Removing noise from data is often the first step in data analysis. Denoising techniques should not only reduce the noise, but do so without blurring or changing the location of the edges. Many approaches have been proposed to accomplish this; in this paper, they focus on one such approach, namely the use of non-linear diffusion operators. This approach has been studied extensively from a theoretical viewpoint ever since the 1987 work of Perona and Malik showed that non-linear filters outperformed the more traditional linear Canny edge detector. They complement this theoretical work by investigating the performance of several isotropic diffusion operators on test images from scientific domains. They explore the effects of various parameters such as the choice of diffusivity function, explicit and implicit methods for the discretization of the PDE, and approaches for the spatial discretization of the non-linear operator etc. They also compare these schemes with ...

2001-12-20

445

On the application of Allan variance method for Ring Laser Gyro performance characterization

Reflectance anisotropy spectroscopy (RAS) has been used, together with scanning tunnelling spectroscopy (STS), to investigate the optical and electronic properties of nanodots formed by depositing Ag on the Si(111)-3 x 1-Ag surface. One-dimensional (1D) arrays of nanodots were grown on a single-domain (3 x 1)-Ag surface and the anisotropic optical response in the 0.5-5 eV range measured by RAS. Aligned, elongated Ag islands were also grown on this surface to compare their properties with those of the nanodots. STS of the Ag islands showed distinct metallic behaviour, whereas the nanodots revealed a bandgap of #approx#0.6 eV, indicating that the surface of the dots has a non-metallic character, similar to that of the Si(111)-3 x 1-Ag surface. RAS also showed substantial differences between the structures, with a large infrared anisotropy for the metallic Ag islands consistent with anisotropic Drude-like intraband transitions, whereas the nanodots gave a negligible ...

2006-08-02

446

Observability of complex ghosts and tachyons

This report describes the method of Allan variance and its application to the characterization of a Ring Laser Gyro`s (RLG) performance. Allan variance, a time domain analysis technique, is an accepted IEEE standard for gyro specifications. The method was initially developed by David Allan of the National Bureau of Standards to quantify the error statistics of a Cesium beam frequency standard employed as the US Frequency Standards in 1960`s. The method can, in general, be applied to analyze the error characteristics of any precision measurement instrument. The key attribute of the method is that it allows for a finer, easier characterization and identification of error sources and their contribution to the overall noise statistics. This report presents an overview of the method, explains the relationship between Allan variance and power spectral density distribution of underlying noise sources, describes the batch and recursive implementation approaches, validates ...

1993-10-15

447

Nuclear resonant spectroscopy at Bragg reflections from periodic multilayers: Basic effects and applications

The complex ghost introduced previously by the present author is studied from a standpoint whether its effects are observable by experiments or not. According to the theory of complex ghost the scattering cross section of two real particles shows some particular properties. It has a kind of resonance peak at a certain energy which does not conform to the Breit-Wigner formula. It has also a peak for a certain energy transfer, if there exist tachyons. The tachyon is a kind of ghost and is allowed to exist in the theory. Using these properties the complex ghosts are expected to be detected by experiments. The recently observed resonance psi(3.1) is supposed to be the complex ghost of photon, since they have the same quantum numbers. If it is assumed, some properties of the resonance known by experiments are explained naturally to a certain extent. Along the same line it is not unnatural to expect that the photon is also accompanied by a tachyon as a ghost. An experiment to detect the ...

448

Neural-network-based voice-tracking algorithm

A systematic study of the Bragg nuclear resonant reflectivity from periodic multilayers in the energy and time domains is presented. Using the kinematical approach of the general reflectivity theory we describe the basic features of the time evolution of the reflected wave after a pulsed excitation of resonant multilayers by synchrotron radiation. Effects of the collective excitation have been examined such as the shift of quantum beat phases, the interplay between electronic and nuclear subsystem excitations depending on their relative position in a multilayer, the energy and time evolution of standing waves inside a resonant multilayer, and their influence on the reflectivity spectra. The exact expression for the reflectivity by a thin resonant layer placed inside a multilayer structure has been derived. The observed shift of the delayed reflectivity Bragg peak relative to the prompt peak is explained by the developed formalism. Experimental applications are ...

2005-09-15

449

Nanomechanical properties of vimentin intermediate filament dimers

A voice-tracking algorithm was developed and tested for the purposes of electronically separating the voice signals of simultaneous talkers. Many individuals suffer from hearing disorders that often inhibit their ability to focus on a single speaker in a multiple speaker environment (the cocktail party effect). Digital hearing aid technology makes it possible to implement complex algorithms for speech processing in both the time and frequency domains. In this work, an average magnitude difference function (AMDF) was performed on mixed voice signals in order to determine the fundamental frequencies present in the signals. A time prediction neural network was trained to recognize normal human voice inflection patterns, including rising, falling, rising-falling, and falling-rising patterns. The neural network was designed to track the fundamental frequency of a single talker based on the training procedure. The output of the neural network can be used to design an ...

2002-11-01

450

Nanoheterostructure Cation Exchange: Anionic Framework Conservation

The cell's cytoskeleton, providing the cell with structure and shape, consists of a complex array of structural proteins, including microtubules, microfilaments and intermediate filaments. Intermediate filaments play a crucial role in mechanotransduction and in providing mechanical stability to cells, in particular under large deformation. By utilizing molecular simulation, here we report a nanomechanical analysis of vimentin intermediate filament dimers, the basic building blocks of intermediate filaments. We describe a detailed analysis of the mechanical properties and associated deformation mechanisms, and find that mechanical stretch induces a transition from alpha-helices to beta-sheets, a phenomenon known as alpha-beta transition. A comparison of the Young's modulus predicted from simulation with experimental measurements is provided, and good agreement is found. We present an analysis of structural changes during deformation, domain unfolding patterns, rate ...

2009-10-21

451

NMR studies of Borrelia burgdorferi OspA, a 28 kDa protein containing a single-layer #beta#-sheet

In ionic nanocrystals the cationic sub-lattice can be replaced with a different metal ion via a fast, simple, and reversible place-exchange, allowing post-synthetic modification of the composition of the nanocrystal, while preserving its size and shape. Here, we demonstrate for the first time that during such an exchange, the anionic framework of the crystal is preserved. When applied to nanoheterostructures, this phenomenon ensures that compositional interfaces within the heterostructure are conserved throughout the transformation. For instance, a morphology composed of a CdSe nanocrystal embedded in a CdS rod (CdSe/CdS) was exchanged to a PbSe/PbS nanorod via a Cu2Se/Cu2S structure. During every exchange cycle, the seed size and position within the nanorod were preserved, as evident by excitonic features, Z-contrast imaging, and elemental line-scans. Anionic framework conservation extends the domain of cation exchange to the design of more complex and unique ...

2010-05-11

452

NADP Regulates the Yeast GAL Induction System

The crystal structure of outer surface protein A (OspA) from Borrelia burgdorferi contains a single-layer #beta#-sheet connecting the N- and C-terminal globular domains. The central #beta#-sheet consists largely of polar amino acids and it is solvent-exposed on both faces, which so far appears to be unique among known protein structures. We have accomplished nearly complete backbone H, C and N and C";/H"#beta# assignments of OspA (28 kDa) using standard triple resonance techniques without perdeuteration. This was made possible by recording spectra at a high temperature (45 "oC ). The chemical shift index and "1"5N T_1/T_2 ratios show that both the secondary structure and the global conformation of OspA in solution are similar to the crystal structure, suggesting that the unique central #beta#-sheet is fairly rigid.

1998-05-01

453

Motion analysis of parallelly connected FPSO unit and LNG carrier

Transcriptional regulation of the galactose-metabolizing genes in Saccharomyces cerevisiae depends on three core proteins: Gal4p, the transcriptional activator that binds to upstream activating DNA sequences (UASGAL); Gal80p, a repressor that binds to the carboxyl terminus of Gal4p and inhibits transcription; and Gal3p, a cytoplasmic transducer that, upon binding galactose and adenosine 5'-triphosphate, relieves Gal80p repression. The current model of induction relies on Gal3p sequestering Gal80p in the cytoplasm. However, the rapid induction of this system implies that there is a missing factor. Our structure of Gal80p in complex with a peptide from the carboxyl-terminal activation domain of Gal4p reveals the existence of a dinucleotide that mediates the interaction between the two. Biochemical and in vivo experiments suggests that nicotinamide adenine dinucleotide phosphate (NADP) plays a key role in the initial induction event.

2008-01-01

454

Molecular dynamic study of different regions of Angelin Pedra (Himenolobium paetrum) wood by low field NMR

Nowadays, the floating production, storage, and offloading (FPSO) units are used to marginal oil fields and deep seas, because of mobility and reduced lead time from discovery to first production. One of the methods for offloading is to moor a tanker alongside the FPSO unit. In this case motion response of the system becomes highly complex, and will be affected by many factors such as hydrodynamic interaction and mechanical connections between the vessels. In this study, a quite general method is developed which has taken into account the hydrodynamic interaction as well as the effects of connectors and mooring lines, in motion response analysis of a multi-body floating system. For this purpose, 3-D source distribution method is applied for hydrodynamic analysis, and linear stiffness matrices are introduced to represent the effect of connectors and mooring lines on the motion equations. The method has been used for motion analysis of a practical problem in which an LNG carrier is ...

1996-12-31

455

Molecular cloning of the human homeobox gene goosecoid (GSC) and mapping of the gene to human chromosome 14q32. 1

Angelin Pedra is a specie found in the north of Mato Grosso State in Brazil, where an expressive volume of waste of this wood is produced. An alternative to recycle this waste is to produce wood plastic composites. However, structural and chemical investigations are fundamental to generate information for this use. In the present work, low field NMR was used to determine the spin-lattice and spin-spin relaxation times with objective to investigate the molecular dynamic behavior of the alburnu and cerne regions of Angelin Pedra aiming at a potential use of this waste wood in polymeric composites. The results of the proton spin-lattice relaxation time (T1H) and the proton spin-spin relaxation time (T2H) showed at least three different mobility domains for both regions. Among the values, one was very flexible and other was rigid. Knowing that wood is a polymer composite basically constituted by cellulose, hemicellulose and lignin can attribute the smaller T1 value and ...

2005-11-06

456

Measurement of W and Z production cross sections with the ATLAS experiment at sqrt(s) = 7 TeV

Goosecoid is a homeobox gene first isolated from a Xenopus dorsal lip cDNA library. Homologous genes have been isolated from mouse, zebrafish, and chick. In all species examined, the gene is expressed and plays an important role during the process of gastrulation in early embryonic development. The authors report here the cloning of the human goosecoid (GSC) from a genomic library and the sequence of its encoded protein. The genomic organization and protein sequence of the human gene are highly conserved with respect to those of its Xenopus and mouse counterparts: all three genes consist of three exons, with conserved exon-intron boundaries. The sequence of the homeo-domain is 100% conserved in most vertebrates. Using somatic cell hybrid and chromosomal in situ hybridization, the gene was mapped to chromosome 14q32.1. 30 refs., 3 figs., 2 tabs.

1994-05-15

457

Magnetic microstructure of candidates for epitaxial dual Heusler magnetic tunnel junctions

W and Z bosons are expected to be produced abundantly at the Large Hadron Collider (LHC). This large dataset and the high LHC energy will allow for detailed studies of their properties in a previously unexplored kinematic domain of low parton momentum fraction and high energy scale thus providing, together with the proton-proton nature of the collisions, new constraints on the parton distribution functions and precise tests of perturbative QCD. First determinations of the W -> lnu and Z -> ll (l = e,mu) production cross sections for proton-proton collisions at sqrt(s) = 7 TeV were performed using about 320/nb of data recorded by the ATLAS experiment at the LHC. The results of these measurements for W and Z bosons for proton-proton collisions at sqrt(s) = 7 TeV are presented. In addition ?rst measurements of the ratio between the W and Z/gamma*-cross sections and of the W -> lnu charge asymmetry are also discussed.

2011-01-01

458

Magnetic and superconducting quantum critical points of heavy-fermion systems

Heusler alloys are considered as interesting ferromagnetic electrode materials for magnetic tunnel junctions, because of their high spin polarization. We, therefore, investigated the micromagnetic properties in a prototypical thin film system comprising two different Heusler phases Co{sub 2}MnSi (CMS) and Co{sub 2}FeSi (CFS) separated by a MgO barrier. The magnetic microstructure was investigated by X-ray photoemission electron microscopy (XPEEM). We find a strong influence of the Heusler phase formation process on the magnetic domain patterns. SiO{sub 2}/V/CMS/MgO/CFS and SiO{sub 2}/V/CFS/MgO/CMS trilayer structures exhibit a strikingly different magnetic behavior, which is due to pinhole coupling through the MgO barrier and a strong thickness dependence of the magnetic ordering in Co{sub 2}MnSi.

2009-05-15

459

Long-term Retinal Function and Structure Rescue Using Capsid Mutant AAV8 Vector in the rd10 Mouse, a Model of Recessive Retinitis Pigmentosa

Two examples of heavy-fermion systems are presented : CePd{sub 2}Si{sub 2}, an antiferromagnet with a quantum critical point at P{sub C}=28 kbar and UGe{sub 2} an itinerant ferromagnet which transits in a paramagnetic phase above P{sub C}=16 kbar. In CePd{sub 2}Si{sub 2} the superconductivity domain is centered on P{sub C}. Special attention was given to the superconducting and magnetic anomalies at their superconducting and Neel temperatures. In UGe{sub 2} superconductivity appears in 9 kbar at a temperature T{sub S}, more than two orders of magnitude lower than the Curie temperature; furthermore, it occurs only on the magnetic border (P<P{sub C}). Another characteristic temperature T{sub X} is detected by resistivity; the zigzag uranium chain of the lattice may favor a supplementary nesting in the majority spin band.

2001-05-01

460

British Library Electronic Table of Contents (United Kingdom)

The retinal degeneration 10 (rd10) mouse is a well-characterized model of autosomal recessive retinitis pigmentosa (RP), which carries a spontaneous mutation in the ? subunit of rod cGMP-phosphodiesterase (PDE?). Rd10 mouse exhibits photoreceptor dysfunction and rapid rod photoreceptor degeneration followed by cone degeneration and remodeling of the inner retina. Here, we evaluate whether gene replacement using the fast-acting tyrosine-capsid mutant AAV8 (Y733F) can provide long-term therapy in this model. AAV8 (Y733F)-smCBA-PDE? was subretinally delivered to postnatal day 14 (P14) rd10 mice in one eye only. Six months after injection, spectral domain optical coherence tomography (SD-OCT), electroretinogram (ERG), optomotor behavior tests, and immunohistochemistry showed tha...

2011-01-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

461

Integrated EM & Thermal Simulations with Upgraded VORPAL Software

Institutt for Energiteknikk - Annual Report 1994

Nuclear physics accelerators are powered by microwaves which must travel in waveguides between room-temperature sources and the cryogenic accelerator structures. The ohmic heat load from the microwaves is affected by the temperature-dependent surface resistance and in turn affects the cryogenic thermal conduction problem. Integrated EM & thermal analysis of this difficult non-linear problem is now possible with the VORPAL finite-difference time-domain simulation tool. We highlight thermal benchmarking work with a complex HOM feed-through geometry, done in collaboration with researchers at the Thomas Jefferson National Accelerator Laboratory, and discuss upcoming design studies with this emerging tool. This work is part of an effort to generalize the VORPAL framework to include generalized PDE capabilities, for wider multi-physics capabilities in the accelerator, vacuum electronics, plasma processing and fusion R&D fields, and we will also discuss user ...

2011-03-01

462

Information report realized for the Senate delegation to the territory management and sustainable development on the local energies; Rapport d'information fait au nom de la delegation du Senat a l'amenagement et au developpement durable du territoire sur les energies locales

Work at Institutt for energiteknikk (IFE) comprises both nuclear and non-nuclear activities. The main nuclear program is centered on the Halden Reactor Project. In 1958, the first Halden Reactor Project Agreement was signed by organisations representing 12 European countries. During 1994 France became a full member and associate membership was established with Russia. Accordingly, 16 countries were participating in the Project by the end of the year. The objectives have evolved from being simply a demonstration of the operation of a boiling heavy-water reactor to becoming a substantial research and development programme covering the domains of human-machine interaction, fuel behaviour, materials testing, water chemistry, and instrumentation. In 1994, significant progress was achieved in all of the areas addressed by the project, including the re-instrumentation of irradiated fuel rods, fission gas release, irradiation-assisted stress corrosion cracking, a ...

1995-12-01

463

Information extraction for enhanced access to disease outbreak reports.

This report deals with the renewable energies and the local development called the territory intelligence in action. Taking into account the place of the electricity in the french energy accounting and the part of the nuclear in its production, the local authorities have to act in the heat domain, which is the first energy need in France, far in front of the specific electricity (those which cannot be replace by other type of energy). But 80% of the heat is today covered by fossil energies. No actions to change this situation will be done without a real implication of the local government. The authors preconize an ambitious objective: cover 50% of the heat needs from renewable energies in the next generat This objective must rely on a program called ''alternative energies''. In this framework the authors provide recommendations on the implementation of the renewable energies as an essential challenge for the local authorities. ...

2006-06-15

464

Incorporating organizational factors into Probabilistic Risk Assessment (PRA) of complex socio-technical systems: A hybrid technique formalization

Document search is generally based on individual terms in the document. However, for collections within limited domains it is possible to provide more powerful access tools. This paper describes a system designed for collections of reports of infectious disease outbreaks. The system, Proteus-BIO, automatically creates a table of outbreaks, with each table entry linked to the document describing that outbreak; this makes it possible to use database operations such as selection and sorting to find relevant documents. Proteus-BIO consists of a Web crawler which gathers relevant documents; an information extraction engine which converts the individual outbreak events to a tabular database; and a database browser which provides access to the events and, through them, to the documents. The information extraction engine uses sets of patterns and word classes to extract the information about each event. Preparing these patterns and word classes has been a time-consuming ...

2002-08-01

465

In situ isotopic analyses of U and Pb in zircon by remotely operated SHRIMP II, and Hf by LA-ICP-MS: an example of dating and genetic evolution of zircon by 176Hf/177Hf from the Ita Quarry in the Atuba Complex, SE, Brazil

This paper is a result of a research with the primary purpose of extending Probabilistic Risk Assessment (PRA) modeling frameworks to include the effects of organizational factors as the deeper, more fundamental causes of accidents and incidents. There have been significant improvements in the sophistication of quantitative methods of safety and risk assessment, but the progress on techniques most suitable for organizational safety risk frameworks has been limited. The focus of this paper is on the choice of 'representational schemes' and 'techniques.' A methodology for selecting appropriate candidate techniques and their integration in the form of a 'hybrid' approach is proposed. Then an example is given through an integration of System Dynamics (SD), Bayesian Belief Network (BBN), Event Sequence Diagram (ESD), and Fault Tree (FT) in order to demonstrate the feasibility and value of hybrid techniques. The proposed hybrid approach ...

2009-05-15

466

Human complement protein C99 is a calcium binding protein

Remotely-operated SHRIMP dating of zircon is an interesting alternative for dating of zircon crystals. Although it does not represent any technical progress of the geochronological method using the U-Pb system in zircon it is a very useful and cheap facility. The procedure was first used for mass spectrometric analyses involving two international laboratories in Sao Paulo, Brazil and Beijing, China. It was applied to samples of three gneiss-migmatitic rocks from the Ita quarry in the Atuba Complex (located between the Luis Alves and the Apiai Domain) to test previous controversial hypotheses about its evolution. The presence of important archaean and paleo proterozoic components in the complex is confirmed by analyses of zircon found in probably neo proterozoic leucosomes. Diorite intrusion also occurred during the neo proterozoic, associated with the 0.6Ga continental collisions involved in the assembly of Gondwana. The determination of Hf isotope ratios by ...

2009-10-01

467

High Spatial Resolution Optical and Radio Imagery of the Circumbinary Environment

Human complement protein C9 is shown to be a metalloprotein that binds 1 mol of Ca"2"+/mol of C9 with a dissociation constant of 3 #mu#m as measured by equilibrium dialysis. Incubation with EDTA removes the bound calcium, resulting in a apoprotein with decreased thermal stability. This loss in stability leads to aggregation and, therefore, to loss of hemolytic activity upon heating to a few degrees above the physiological temperature. Heat-induced aggregation of apoC9 can be prevented by salts that stabilize proteins according to the Hofmeister series of lyotropic ions, suggesting that the ion in native C9 may ligand with more than one structural element of domain of the protein. Ligand blotting indicates that the calcium binding site is located in the amino-terminal half of the protein. Removal of calcium by inclusion of EDTA in assay mixtures has no effect on the hemolytic activity of C9, and its capacity to bind to C8 in solution, or to small unilamellar lipid ...

468

Geological evolution of the center-southern portion of the Guyana shield based on the geochemical, geochronological and isotopic studies of paleoproterozoic granitoids from southeastern Roraima, Brazil; Evolucao geologica da porcao centro-sul do escudo das Guianas com base no estudo geoquimico, geocronologico e isotopico dos granitoides paleoproterozoicos do sudeste de Roraima, Brasil

In this review, I concentrate on describing observations of spatially resolved emission in symbiotic stars at sub-arcsecond scales. In some of the closer objects, the highest resolutions discussed here correspond to linear dimensions similar to the supposed binary separation. A total of 17 stars well accepted as symbiotics are now observed to show sub-arcsecond structure, almost twice the number at the time of the last review in 1987. Furthermore, we now have access to HST imagery to add to radio interferometry. From such observations we can derive fundamental parameters of the central systems, investigate the variation of physical parameters across the resolved nebulae and probe the physical mechanisms of mass loss and interactions between ejecta and the circumstellar medium. Suggestions for future work are made and the potential of new facilities in both the radio and optical domains is described. This review complements that by Corradi (this volume) which mainly ...

2004-01-01

469

Genetic organization of Bungarus multicinctus protease inhibitor-like proteins.

This study focuses the granitoids of center-southern portion of Guyana Shield, southeastern Roraima, Brazil. The region is characterized by two tectonic-stratigraphic domains, named as Central Guyana (GCD) and Uatuma-Anaua (UAD) and located probably in the limits of geochronological provinces (e.g. Ventuari-Tapajos or Tapajos-Parima, Central Amazonian and Maroni-Itacaiunas or Transamazon). The aim this doctoral thesis is to provide new petrological and lithostratigraphic constraints on the granitoid rocks and contribute to a better understanding of the origin and geo dynamic evolution of Guyana Shield. The GCD is only locally studied near to the UAD boundary, and new geological data and two single zircon Pb-evaporation ages in mylonitic biotite granodiorite (1.89 Ga) and foliated hastingsite-biotite granite (1.72 Ga) are presented. These ages of the protholiths contrast with the lithostratigraphic picture in the other areas of Cd (1.96-1.93 Ga). Regional mapping, ...

2006-07-01

470

Fuzzy decision making in multiobjective long-term scheduling of hydrothermal system

The structural organization of the genes encoding Bungarus multicinctus protease inhibitor-like proteins (PILPs), PILP-1, PILP-2 and PILP-3, are reported in this study. Unlike PILP-2 and PILP-3, recombinant PILP-1 exhibited inhibitory activity on trypsin. PILP genes and B chain genes shared identical organization with three exons interrupted by two introns in similar positions. On the contrary, intron 1 of these genes had a similar size, a notable variation with the size of intron 2 was observed. It was found that two regions at the second intron of B1 chain and B2 chain genes were absent in that of PILP genes. Noticeably, intronic insertion in the second intron of B chain genes appeared in the promoter region of PILP-1 gene, but not in that of PILP-2 and PILP-3 genes. Comparative analyses of PILP genes and B chain genes showed that the protein-coding regions of the exons are more diverse than introns, except for in the signal peptide domain. These results suggest ...

2008-03-27

471

Functional MRI of the pharynx in obstructive sleep apnea (OSA) with rapid 2-D flash sequences

In the paper, a fuzzy decision-making methodology is presented to decide the generation schedule of long-term hydrothermal problems with explicit recognition of statistical uncertainties in system production cost data, NO{sub x} emission data, system load demand and hydro reservoir water inflows. In deciding the optimal operation, three objectives operating cost, NO{sub x} emission and unsatisfied load demand over the whole of the planning period are simultaneously minimised. Specific technique is put forth to convert the stochastic models into their deterministic equivalents. The weighted minimax method is used to simulate the tradeoff relation between the conflicting objectives in the non-inferior domain. The fuzzy set theory is exploited to choose the best operating point over the tradeoff curve. An efficient decomposition technique is applied to reduce the complexity of the problem. In each subproblem, thermal generations are obtained by using simplified method ...

2001-01-01

472

France, an international partner in the climate change field; La France, partenaire international dans le domaine du changement climatique

Functional imaging of the pharynx used to be the domain of cineradiography, CT and ultrafast CT. The development of modern MRI techniques led to new access to functional disorders of the pharynx. The aim of this study was to implement a new MRI technique to examine oropharyngeal obstructive mechanisms in patients with obstructive sleep apnea (OSA). Sixteen patients suffering from OSA and 6 healthy volunteers were examined on a 1.5 T whole-body imager ('Vision', Siemens, Erlangen Medical Engineering, Germany) using a circular polarized head coil. Imaging was performed with 2D flash sequences in midsagittal and axial planes. Patients and volunteers were asked to breathe normally through the nose and to simulate snoring and the Mueller maneuver during magnetic resonance imaging (MRI). Prior to MRI, all patients underwent an ear, nose and throat (ENT) examination, functional fiberoptic nasopharyngoscopy and polysomnography. A temporal resolution of 6 images/s and an ...

473

Exploring Quantum Gravity with Very-High-Energy Gamma-Ray Instruments - Prospects and Limitations

Cooperation for low carbon and energy efficient development is a high priority for France, in line with the United Nations Framework Convention on Climate Change. France contributes to tackling climate change by working with its partners on all continents to implement projects both to mitigate greenhouse gas emissions and to adapt to climate change. Within the framework of the Marrakech Accords, France also encourages the implementation of the Kyoto Protocol Clean Development Mechanism, in particular between French business and non-Annex I countries; this mechanism will facilitate the financing of mitigation projects and contribute to the sustainable development of host countries in the South. At multilateral level, France is a major donor. At a bilateral level, an initial analysis of cooperation projects which are strongly linked to tackling climate change identified public support of 136 millions euros per year, as an average over the past few years. Some project examples, mostly ...

2004-07-01

474

Experimental and theoretical studies of coherent and nonthermal processes in semiconductors probed by femtosecond laser techniques

Some models for quantum gravity (QG) violate Lorentz invariance and predict an energy dependence of the speed of light, leading to a dispersion of high-energy gamma-ray signals that travel over cosmological distances. Limits on the dispersion from short-duration substructures observed in gamma-rays emitted by gamma-ray bursts (GRBs) at cosmological distances have provided interesting bounds on Lorentz invariance violation (LIV). Recent observations of unprecedentedly fast flares in the very-high energy gamma-ray emission of the active galactic nuclei (AGNs) Mkn 501 in 2005 and PKS 2155-304 in 2006 resulted in the most constraining limits on LIV from light-travel observations, approaching the Planck mass scale, at which QG effects are assumed to become important. I review the current status of LIV searches using GRBs and AGN flare events, and discuss limitations of light-travel time analyses and prospects for future instruments in the gamma-ray domain.

2009-01-01

475

Existence and equilibration of global weak solutions to finitely extensible nonlinear bead-spring chain models for dilute polymers

The coherent interaction of femtosecond laser pulses and a thin CdSe sample is investigated both experimentally and theoretically. Observation of coherent phenomena in semiconductors is very rare because the incoherent processes occur in the femtosecond time domain in these materials. One example of such a phenomena is the so called optical Stark effect of exciton where a blue shift of the exciton resonance occurs as a result of pumping below the bandgap. The coherent effects involving band-to-band and also exciton transitions. Using femtosecond transmission measurements clear evidence was observed for coherent interference effects of the light field and the driven material polarization. These interferences manifest themselves as oscillatory structures in the differential transmission spectra. The oscillatory features are explained by comparison with a semiclassical theory. Examples of the computed results are presented for different time delays between probe and ...

1987-01-01

476

Evolution of a molecular switch: universal bacterial GTPases regulate ribosome function.

We show the existence of global-in-time weak solutions to a general class of coupled FENE-type bead-spring chain models that arise from the kinetic theory of dilute solutions of polymeric liquids with noninteracting polymer chains. The class of models involves the unsteady incompressible Navier-Stokes equations in a bounded domain in two or three space dimensions for the velocity and the pressure of the fluid, with an elastic extra-stress tensor appearing on the right-hand side in the momentum equation. The extra-stress tensor stems from the random movement of the polymer chains and is defined by the Kramers expression through the associated probability density function that satisfies a Fokker-Planck-type parabolic equation, a crucial feature of which is the presence of a center-of-mass diffusion term. We require no structural assumptions on the drag term in the Fokker-Planck equation; in particular, the drag term need not be corotational. With a square-integrable ...

2010-01-01

477

Estimating $\\omega$ from Galaxy Redshifts Linear Flow Distortions and Nonlinear Clustering

The GTPases comprise a protein superfamily of highly conserved molecular switches adapted to many diverse functions. These proteins are found in all domains of life and often perform essential roles in fundamental cellular processes. Analysis of data from genome sequencing projects demonstrates that bacteria possess a core of 11 universally conserved GTPases (elongation factor G and Tu, initiation factor 2, LepA, Era, Obg, ThdF/TrmE, Ffh, FtsY, EngA and YchF). Investigations aimed at understanding the function of GTPases indicate that a second conserved feature of these proteins is that they elicit their function through interaction with RNA and/or ribosomes. An emerging concept suggests that the 11 universal GTPases are either necessary for ribosome function or transmitting information from the ribosome to downstream targets for the purpose of generating specific cellular responses. Furthermore, it is suggested that progenitor GTPases were early regulators of RNA ...

2001-07-01

478

Electrochemical ozone production: influence of the supporting electrolyte on kinetics and current efficiency

We propose a method to determine the cosmic mass density Omega from redshift-space distortions induced by large-scale flows in the presence of nonlinear clustering. Nonlinear structures in redshift space such as fingers of God can contaminate distortions from linear flows on scales as large as several times the small-scale pairwise velocity dispersion sigma_v. Following Peacock & Dodds (1994), we work in the Fourier domain and propose a model to describe the anisotropy in the redshift-space power spectrum; tests with high-resolution numerical data demonstrate that the model is robust for both mass and biased galaxy halos on translinear scales and above. On the basis of this model, we propose an estimator of the linear growth parameter beta = Omega^0.6/b, where b measures bias, derived from sampling functions which are tuned to eliminate distortions from nonlinear clustering. The measure is tested on the numerical data and found to recover the true value of beta ...

1997-01-01

479

Effects of Thermal Annealing Upon the Nanomorphology of Poly(3-hexylselenophene)-PCBM Blends

The nature of the electrolyte strongly influences the electrode kinetics of the oxygen evolution reaction (OER) and electrochemical ozone production (EOP) mainly by affecting the degree of coverage by the intermediates of both processes. The anomalous behaviour of the Tafel coefficient, b, as a function of temperature was attributed to surface adsorption of the electrolyte species, and the competition between them, as well as gas bubble adherence. Comparison of the current efficiencies of the EOP, PHI_E_O_P, determined for different temperatures and supporting electrolyte compositions, showed the presence of fluorinated anions increases PHI_E_O_P. The influence of the anion nature on PHI_E_O_P, when analysed in the light of the proposed electrode mechanism, reveals introduction into the electrolyte of anions having a high electronegativity changes the double layer structure resulting in an increase of surface concentration of the active centres leading to EOP. The inhibition of the OER ...

2003-02-05

480

British Library Electronic Table of Contents (United Kingdom)

Abstract Grazing incidence X-ray diffraction (GI-XRD) is used to characterize the crystallographic dynamics of low molecular weight (LMW) and high molecular weight (HMW) poly(3-hexylselenophene) (P3HS) films and blend films of P3HS with [6-6-]-phenyl-C61-butyric acid methyl ester (PCBM) as a function of -step-by-step- thermal annealing, from room temperature to 250-C. The temperature-dependent GIXRD data show how the melting point of P3HS crystallites is decreased by the presence of PCBM. P3HS crystallite domain sizes dramatically increase upon annealing to the P3HS melting temperature. The formation of well-oriented HMW P3HS crystallites with the (100) plane parallel to the substrate (edge-on orientation), when cooled from melt, are observed. We compare the behaviour of P3HS pure and blen...

2011-01-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

481

Dynamic stability enhancement of East-Central System in Saudi Arabia via PSS Tuning

Development of the discrete-time adaptive sliding mode power system stabilizer

This paper presents a practical case study on the dynamic stability of the Saudi Electricity Company (SEC) power system and its effect on increasing power transfer limit of the interconnection between Eastern Operating Area (SEC-EOA). The problem of optimal tuning of the power system stabilizer parameters was converted into optimization problem wth eigenvalue-based objective functions, which was then solved by genetic algorithms. In this regard, two eigenvalue-based objective functions were considered and the problem is solved using real-coded genetic algorithm (RCGA). The effectiveness of the suggested technique to enhance the power system dynamic stability and to extend the power transfer capability limit of the SEC-EOA and the SEC-EOA power system was verified through a comprehensive eigenvalue analysis and time-domain nonlinear simulation. The results also indicated that the proposed tuning schemes of the existing stabilizers in the system have led to an ...

2007-01-01

482

Design and x-ray crystal structures of high-potency nonsteroidal glucocorticoid agonists exploiting a novel binding site on the receptor

A newly developed discrete-time adaptive sliding mode power system stabilizer (PSS) is proposed in this paper. Because the proposed PSS is developed in the pure discrete-time domain it is able to maintain the stability with the rather slower smapling frequency compared to discretized conventional continuous-time sliding mode PSS. The proposed PSS has the three main superiorities to the conventional PSS. First, because the proposed PSS utilizes the sliding mode control method, it has the strong robustness to the variations of the system parameters. Hence, it can overcome the minor disturbances such as identification errors, modeling errors, etc. Second, the proposed PSS needs only input/output measurements as feedback signals. Hence, it does not need the measurements of the state variables as the conventional sliding mode PSS or PSS based on the linear quadratic control method does. Finally, because the proposed PSS have the adaptive property, it is able to overcome ...

1996-12-31

483

Control of linear accelerator noise in the Los Alamos free-electron laser (FEL)

Crystallography and computer modeling have been used to exploit a previously unexplored channel in the glucocorticoid receptor (GR). Highly potent, nonsteroidal indazole amides showing excellent complementarity to the channel were designed with the assistance of the computational technique AlleGrow. The accuracy of the design process was demonstrated through crystallographic structural determination of the GR ligand-binding domain-agonist complex of the D-prolinamide derivative 11. The utility of the channel was further exemplified through the design of a potent phenylindazole in which structural motifs, seen to interact with the traditional GR ligand pocket, were abandoned and replaced by interactions within the new channel. Occupation of the channel was confirmed with a second GR crystal structure of this truncated D-alaninamide derivative 13. Compound 11 displays properties compatible with development as an intranasal solution formulation, whereas oral ...

2010-09-17

484

Consistency of the phenomenological theories of wave-type heat transport with the hydrodynamics of a phonon gas

The Los Alamos FEL requires tight control of the amplitudes and phases of the fields in two linear accelerator tanks to obtain stable lasing. The accelerator control loops must establish constant, stable, repeatable amplitudes and phases of the rf fields and must have excellent bandwidth to control high-frequency noise components. A model of the feedback loops has been developed that agrees well with measurements and allows easy substitution of components and circuits, thus reducing breadboarding requirements. The model permits both frequency and time-domain analysis. This paper describes the accelerator control scheme and our model and discusses the control of noise in feedback loops, showing how low-frequency-noise components (errors) can be corrected, but high-frequency-noise components (errors) are actually amplified by the feedback circuit. Measurements of noise in both open- and closed-loop modes are shown and comparison is made with results from the model ...

1986-06-02

485

Comparison of power system stabilizer design using H{sub {infinity}} optimization and {mu}-synthesis approach

Various phenomenological theories of wave-type heat transport, which can be interpreted as the models of an isotropic rigid heat conductor with an internal vector state variable, have been proposed in the literature with the objective to describe the second sound propagation in dielectric crystals. The aim of this paper is to analyze the relation between these phenomenological approaches and the phonon gas hydrodynamics. The four-moment phonon gas hydrodynamics based on the maximum entropy closure of the moment equations with nonlinear isotropic phonon dispersion relation is considered for this purpose. We reformulate the equations of this hydrodynamics in terms of energy and quasi-momentum as the primitive fields and subsequently demonstrate that, from the macroscopic point of view, they can be understood as describing the reference model of an isotropic rigid heat conductor with quasi-momentum playing the role of the internal vector state variable. This model is determined by the ...

2010-09-24

486

Characterization of proton exchange membrane materials for fuel cells by solid state nuclear magnetic resonance

Power system operating conditions vary with system configurations and loading conditions. Coefficients in nominal system model change in a complex manner with different operating point and so does system dynamic behavior. With the aid of unstructured and structured uncertainty descriptions, the worst system variations can be estimated and formulated into two different uncertainty models in frequency domain; multiplicative unstructured uncertainty in the form of transfer function and structured uncertainty with the parametric uncertainty description. The uncertainty descriptions are then incorporated into system nominal model to perform H{sub {infinity}} and {mu} based robust power system stabilizer (PSS) design. Both approaches to the PSS design enable the power system to remain stable over a wide range of system operating conditions but the different performance can be observed due to the inheritance of the ways to handle the system uncertainty. 8 refs, 8 figs, 1 ...

1995-11-01

487

Characterization of a novel missense mutation on murine Pax3 through ENU mutagenesis.

Solid-state nuclear magnetic resonance (NMR) has been used to explore the nanometer-scale structure of Nafion, the widely used fuel cell membrane, and its composites. We have shown that solid-state NMR can characterize chemical structure and composition, domain size and morphology, internuclear distances, molecular dynamics, etc. The newly-developed water channel model of Nafion has been confirmed, and important characteristic length-scales established. Nafion-based organic and inorganic composites with special properties have also been characterized and their structures elucidated. The morphology of Nafion varies with hydration level, and is reflected in the changes in surface-to-volume (S/V) ratio of the polymer obtained by small-angle X-ray scattering (SAXS). The S/V ratios of different Nafion models have been evaluated numerically. It has been found that only the water channel model gives the measured S/V ratios in the normal hydration range of a working fuel ...

2010-03-15

488

CAA broadband noise prediction for aeroacoustic design

N-ethyl-N-nitrosourea (ENU) mutagenesis has led to the elucidation of several regulator genes for melanocyte and skin development. Here we characterized a mutant from ENU mutagenesis with similar phenotype as that of Splotch mutant, including exencephaly, spina bifida and abnormal limbs in homozygotes as well as white belly spotting and occasionally loop-tail in heterozygotes. This novel mutant was named as Sp(xG). Through genome-wide linkage analysis in backcross progenies with microsatellite markers, the Sp(xG) was confined to a region between D1MIT415 and D1MIT7 on chromosome 1, where notable Pax3 gene was located. Direct sequencing revealed that Sp(xG) carried a nucleotide A894G missense transition in exon 6 of Pax3 gene that resulted in Asn to Asp substitution at amino acid 269 within the highly-conserved homeodomain (HD) DNA recognition module, which was the first point mutation found in this domain in mice. This N269D mutation impaired the transactivation ...

2011-07-19

489

Analysis of the roles of E6 binding to E6TP1 and nuclear localization in the human papillomavirus type 31 life cycle

The current status of a computational aeroacoustics (CAA) approach to simulate broadband noise is reviewed. The method rests on the use of steady Reynolds averaged Navier-Stokes (RANS) simulation to describe the time-averaged motion of turbulent flow. By means of synthetic turbulence the steady one-point statistics (e.g. turbulence kinetic energy) and turbulent length- and time-scales of RANS are translated into fluctuations having statistics that very accurately reproduce the initial RANS target-setting. The synthetic fluctuations are used to prescribe sound sources which drive linear perturbation equations. The whole approach represents a methodology to solve statistical noise theory with state-of-the-art CAA tools in the time-domain. A brief overview of the synthetic turbulence model and its numerical discretization in terms of the random particle-mesh (RPM) and fast random particle-mesh (FRPM) method is given. Results are presented for trailing-edge noise, slat ...

2011-08-01

490

British Library Electronic Table of Contents (United Kingdom)

The E6 oncoproteins of high-risk human papillomaviruses provide important functions not only for malignant transformation but also in the productive viral life cycle. E6 proteins have been shown to bind to a number of cellular factors, but only a limited number of analyses have investigated the effects of these interactions on the viral life cycle. In this study, we investigated the consequences of HPV 31 E6 binding to E6TP1, a putative Rap1 GAP protein. HPV 16 E6 has been shown to bind as well as induce the rapid turnover of E6TP1, and similar effects were observed with HPV 31 E6. Mutation of amino acid 128 in HPV 31 E6 was found to abrogate the ability to bind and degrade E6TP1 but did not alter binding to another ?-helical domain protein, E6AP. When HPV 31 genomes containing mutations a...

2007-01-01

491

An adaptive self-optimizing power system stabilizer

Aluminum-containing intergranular phases in hot-pressed silicon carbide

A self-optimizing pole-shifting control algorithm has been developed for an adaptive power system stabilizer (APSS) to improve its dynamic performance and autonomous operation. The proposed algorithm deals with the system frequency and time domain characteristics simultaneously to guarantee stability and to enhance the performance of the closed-loop system. The mechanism of discrete control system control limits influencing the closed loop system behaviour is studied. Short-term behaviour is studied by introducing the concept of a short-term behaviour index. With the introduction of dynamic control limits, an effective discrete control system design method is proposed. A PSS oriented power system dynamics simulation package (PSDSP) has been developed. Using the PSDSP, simulation studies were performed with the proposed APSS applied to a single machine and a multi machine power system. The performance of the APSS is satisfactory and is discussed. An Intel iSBC386/21 ...

1994-01-01

492

Alteration of alpha 1 Na+,K(+)-ATPase "8"6Rb"+ influx by a single amino acid substitution

Aluminum-containing intergranular phases, forming intergranular films and secondary phase particles at triple-junctions in SiC hot-pressed with aluminum, boron, and carbon additions, were studied by transmission electron microscopy. Statistical high-resolution electron microscopy study of intergranular films indicated that a large fraction of the vitreous intergranular films in the s-hot-pressed SiC crystallized during postannealing in argon above 1000 C. However, brief heating to 1900 C indeed re-melted 25 percent of the crystallized intergranular films. The structural transitions were reflected in the statistical width distributions of the amorphous grain boundary layers. At triple-junctions, Al2O3, Al2OC-SiC solid solution, and mullite phases were newly identified. These phases,together with others reported before are represented in a quaternary phase diagram for 1900 C. It is proposed that a SiC-Al2OC liquid domain is to be included in this phase diagram.

2003-01-12

493

Advanced solution algorithms for transient multidimensional thermohydraulic flow problems in complex geometries with the programme COMMIX-2/KfK

The sodium- and potassium-dependent adenosine triphosphatase (Na+,K(+)-ATPase) maintains the transmembrane Na+ gradient to which is coupled all active cellular transport systems. The R and S alleles of the gene encoding the Na+,K(+)-ATPase alpha 1 subunit isoform were identified in Dahl salt-resistant (DR) and Dahl salt-sensitive (DS) rats, respectively. Characterization of the S allele-specific Na+,K(+)-ATPase alpha 1 complementary DNA identified a leucine substitution of glutamine at position 276. This mutation alters the hydropathy profile of a region in proximity to T3(Na), the trypsin-sensitive site that is only detected in the presence of Na+. This mutation causes a decrease in the rubidium-86 influx of S allele-specific sodium pumps, thus marking a domain in the Na+,K(+)-ATPase alpha subunit important for K+ transport, and supporting the hypothesis of a putative role of these pumps in hypertension.

494

Advanced solution algorithms for transient multidimensional thermohydraulic flow problems in complex geometries with the programme COMMIX-2/KfK

The computer programme COMMIX-2 describes steady state and transient multidimensional single- and two-phase fluid flows with heat transfer in nuclear reactor components and multicomponent systems. Originally from the Argonne National Laboratory, the code has been further developed at the Kernforschungszentrum Karlsruhe. The original Point-SOR iterative method for the solution of a Poisson-like equation describing the pressure distribution in the fluid as well as the transport of enthalpy and turbulent quantities has been complemented with iterative and direct line- and block-methods. None of the newly implemented methods is original in itself but their implementation into the computer code, which can describe the most general shapes of definition domains, gave a code speed-up by a factor of 2-5, depending on the problem treated. The code capabilities are assessd by the calculation of a benchmark problem involving the numerical simulation of thermal buoyancy ...

1987-03-01

495

Adaptive local basis set for Kohn-Sham density functional theory in a discontinuous Galerkin framework I: Total energy calculation

The computer programme COMMIX-2 describes steady state and transient multidimensional single- and two-phase fluid flows with heat transfer in nuclear reactor components and multicomponent systems. Originally from the Argonne National Laboratory, the code has been further developed at the Kernforschungszentrum Karlsruhe. The original Point-SOR iterative method for the solution of a Poisson-like equation describing the pressure distribution in the fluid as well as the transport of enthalpy and turbulent quantities has been complemented with iterative and direct line- and block-methods. None of the newly implemented methods is original in itself but their implementation into the computer code, which can describe the most general shapes of definition domains, gave a code speed-up by a factor of 2-5, depending on the problem treated. The code capabilities are assessd by the calculation of a benchmark problem involving the numerical simulation of thermal buoyancy ...

1987-01-01

496

A novel approach to personal photo album representation and management

Kohn-Sham density functional theory is one of the most widely used electronic structure theories. Uniform discretization of the Kohn-Sham Hamiltonian generally results in a large number of basis functions per atom in order to resolve the rapid oscillations of the Kohn-Sham orbitals around the nuclei. Previous attempts to reduce the number of basis functions per atom include the usage of atomic orbitals and similar objects, but the atomic orbitals generally require fine tuning in order to reach the chemical accuracy. We present a novel discretization scheme that adaptively and systematically builds the rapid oscillations of the Kohn-Sham orbitals around the nuclei as well as environmental effects into the basis functions. The resulting basis functions are localized in the real space, and are discontinuous in the global domain. The continuous Kohn-Sham orbitals and the electron density are evaluated from the discontinuous basis functions using the discontinuous ...

2011-01-01

497

A global geographic information system data base of storm occurrences and other climatic phenomena affecting coastal zones

In this paper we present a novel approach to personal photo album management allowing the end user to efficiently access the collection without any need for tedious manual annotation or indexing of the photos. The proposed work exploits methods and technology from the field of computer vision and pattern recognition for face detection, face representation and image annotation to automatically create description of images useful for content-based searching and retrieval. In fact, even if most of the used techniques are not reliable enough to address the general problem of content-based image retrieval, we show that, in a limited domain such as the one of personal photo album, it is possible to obtain results that improve the browsing capabilities of current photo album management systems. In particular, starting from the observation that most personal photos depict a usually small number of people in a relatively small number of different context (indoor, outdoor, ...

2008-01-01

498

A comparison of atmospheric transport considerations in eastern and western oil shale operations

This document describes the contents of a digital climatological data set that may be used by raster or vector geographic information systems (GISs). The primary focus of the data set is the quantification of the occurrence of synoptic storms and other climatological factors that affect coastlines. However, recent demands for new and/or improved climatologies of storm events as well as an increase in the availability of source data have made it useful to extend the domain of most of the data variables to that of regional and/or global coverage. The expansion of the data makes the data set applicable in several areas of climatic research. The data set contains eight data groups. Spatial coverage of data varies by data group. All data groups except one are referred to 1{degree} {times} 1{degree} or 5{degree} {times} 5{degree} grid cells of latitude and longitude. (Data group (3) is referenced by state.) 19 refs., 12 figs., 26 tabs.

1991-05-01

499

A Wide-Band Electromagnetic Impedance Profiling System forNon-Invasive Subsurface Characterization

Atmospheric transport represents one of the critically important pathways for the distribution of pollutants from any oil shale operation. Our experience in studying eastern and western shale resources and operation suggest many common features regarding the atmospheric domain, but also many significant differences. Any issue of atmospheric transport and dispersion can be broken down into major elements: source factors which include the spatial and temporal distribution of pollutant sources as well as their chemical and physical characteristics, boundary conditions which include the character of the underlying surface as a lower boundary and the large scale meteorological circulations as an ''upper'' boundary; and meteorological structure is the resulting wind, temperature, moisture, and turbulence environment in the volume of air occupied by emitted material in an atmosphere subjected to the boundary conditions described above. ...

1987-01-01

500