International Nuclear Information System (INIS)

Chemical analyses were done on the abnormal hemoglobins of the five (101 x SEC)F_1 offspring of X- irradiated adult SEC mice to determine which hemoglobin genes were expressed in each hemoglobin variant. Three offspring of irradiated SEC males did not express either of the two kinds of #alpha#-chains normally found in all SEC mice. The deficient #alpha#-chain synthesis caused these mice to exhibit an #alpha#-thalassemia similar to human #alpha#-thalassemia. Scanning electron microscopy was used to show that many erythrocytes of mice with #alpha#-thalassemia have bizarre shapes; e.g. many erythrocytes appeared flattened or had thorny projections (acanthocytes). One mutant with a tandem duplication of a segment of chromosome 7 (site of locus determining #beta#-chain structure) produced twice as much SEC as 101 #beta#-chain ...

Energy Technology Data Exchange (ETDEWEB)

Water-soluble, ethanol-insoluble extracts prepared from several medicinal herbs of the Araliaceae and other families were tested for their radioprotective activity by either measuring 30 days survival rates (a commonly applied method) or counting the thrombocytes 14 days after irradiation (an improved method) in mice. The extracts were i.p. injected once within 4 min after the whole body X-ray irradiation. Of 12 materials examined, Aralia elata, Angelica acutiloba and Morus bombysis seemed to be good starting materials for preparing radioprotective substance(s) because of their relatively high specific activity and high yields of the extracts. (author).

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An assay system for the stem cell that colonizes the thymus and differentiates into T cells was developed, and by using this assay system the existence of two subpopulations of stem cells for T cell lineage was clarified. Part-body-shielded and 900-R-irradiated C57BL/6 (H-2b, Thy-1.2) recipient mice, which do not require the transfer of pluripotent stem cells for their survival, were transferred with cells from B10 X Thy-1.1 (H-2b, Thy-1.1) donor mice. The reconstitution of the recipient's thymus lymphocytes was accomplished by stem cells in the donor cells and those spared in the shielded portion of the recipient that competitively colonize the thymus. Thus, the stem cell activity of donor cells can be evaluated by determining the proportion of donor-type (Thy-1.1+) cells in the recipient's thymus. Bone marrow cells were the most potent source of stem cells. By contrast, when the stem ...

Energy Technology Data Exchange (ETDEWEB)

The radiosensitivity of spermatogonial stem cells of C3H/HeHx101/H F[sub 1] hybrid mice was determined by counting undifferentiated spermatogonia at 10 days after X-irradiation. During the spermatogenic cycle, differences in radiosensitivity were found, which were correlated with the proliferative activity of the spermatogonial stem cells. In stage VIII[sub irr], during quiescence, the spermatogonial stem cells were most radiosensitive with a D[sub 0] of 1.4 Gy. In stages XI[sub irr]-V[sub irr], when the cells were proliferatively active, the D[sub 0] was about 2.6 Gy. Based on the D[sub 0] values for sensitive and resistant spermatogonia and on the D[sub 0] for the total population, a ratio of 45:55% of sensitive to resistant spermatogonial stem cells was estimated for cell killing. When the present data were compared with data on translocation induction obtained in mice of the same genotype, a close fit was obtained when ...

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Elevation of zinc protoporphyrin (ZPP) levels in the blood has served as an indicator of lead poisoning and iron deficiency anemia for many years. We have discovered that sublethal doses of whole body irradiation with x-rays also elevates ZPP 2-3-fold over normal levels. The ZPP level does not begin to increase until days 12-14 postirradiation and peaks between days 18 and 20 before returning to normal levels between days 28 and 35. Increasing the radiation dose delays the onset of the rise in ZPP, but does not affect the magnitude of the elevation. At lethal doses, ZPP elevation is not observed. Neither of the two previously described mechanisms that cause elevations of ZPP, namely iron deficiency and inhibition of ferrochelatase, are responsible for the radiation-induced elevation of ZPP. The elevation of ZPP appears to be correlated with the recovery of the hematopoietic system from radiation injury.

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One such agent is the widely used anesthetic, halothane. To study the toxicity of u.v. decomposed halothane, mice were exposed to anesthetic concentrations (1.3%) of non- and u.v.-irradiated halothane in oxygen for 90 min. Halothane sleeping times increased from 14.3 min to 72.5 min. Microsomal mixed function oxidase activity decreased, as shown by prolonged pentobarbital sleeping times 1 day after exposure to halothane and irradiated halothane (54.6 min and 149.1 min, respectively, as compared to a 34.6-min control). Quantitative and qualitative differences were found in the amount of (/sup 14/C)-pentobarbital metabolites excreted by u.v. irradiated halothane-exposed mice compared to either oxygen or non-irradiated halothane-exposed groups. In addition, serum glutamic-oxalacetic transaminase (SGOT) of irradiated halothane-exposed ...

UK PubMed Central (United Kingdom)

It has been postulated that fetal vascular abnormalities in aryl hydrocarbon receptor null (ahr^{−/−}) mice may alter cardiovascular homeostasis in adulthood....Full Text Available

Energy Technology Data Exchange (ETDEWEB)

The effect of adriamycin in combination with radiation on the skin reactions of mouse feet has been examined under a variety of experimental conditions including: (a) hyperthermic treatment of the foot immediately following adriamycin administration, with the former given either just before or just after x irradiation, and (b) fractionated treatments of drug and radiation in a variety of sequences over an 18-day period. In the case of the most severe hyperthermic treatment, no increased radiation reactions were observed in the presence of adriamycin. However, in the case of the less severe hyperthermic treatment a small but significant increase in skin reactions was observed. In the study of fractionated drug and radiation treatments, an enhancement of reaction in those animals receiving combined modality treatment over those receiving radiation alone was seen in those groups where the initiation of drug treatment succeeded the initiation of ...

Science.gov (United States)

... estrogen receptor status. Cancer Lett., 253, 291-300. 39. Xin,X ... and resistant mice. Brain Res.Bull., 52, 235-242. 40. Foster,BA ...

UK PubMed Central (United Kingdom)

PurposePrevious studies have demonstrated that in 129α3Cx46^{−/−} mice, age-related nuclear cataract is formed. In...Full Text Available

UK PubMed Central (United Kingdom)

IntroductionIrradiation of normal, non-malignant bone during cancer therapy can lead to atrophy and increased risk of fracture at several skeletal sites, particularly...Full Text Available

UK PubMed Central (United Kingdom)

We have recently reported that progeroid Zmpste24^{−/−} mice, which exhibit multiple defects that phenocopy Hutchinson-Gilford progeria syndrome, show a profound dysregulation...Full Text Available

British Library Electronic Table of Contents (United Kingdom)

Cholestatic liver injury induced by alpha-naphthylisothiocyanate (ANIT) is provoked by injury to intrahepatic bile ducts and the progression of hepatic necrosis requires the procoagulant protein tissue factor (TF) and extrahepatic cells including neutrophils. Recent studies have shown that myeloid cell TF contributes to neutrophil activation. We tested the hypothesis that myeloid cell TF contributes to neutrophil activation in ANIT-treated mice. TF activity in liver homogenates increased significantly in TF^f^l^o^x^/^f^l^o^x mice treated with ANIT, but not in TF^f^l^o^x^/^f^l^o^x/LysMCre mice (TFD^M^y^e^l^o^i^d mice), which have reduced TF expression in monocytes/macrophages and neutrophils. Myeloid cell-specific TF deficiency did not alter expression of the chemokines KC or MIP-2 but redu...

UK PubMed Central (United Kingdom)

Amyloid plaques are a characteristic feature in Alzheimer’s disease (AD). A novel non-toxic contrast agent is presented, Gd-DTPA-K6Aβ1–30, which is homologous to Aβ,...Full Text Available

UK PubMed Central (United Kingdom)

Patients with Alport syndrome progressively lose renal function as a result of defective type IV collagen in their glomerular basement membrane. In mice lacking the α3 chain of type IV collagen...Full Text Available

UK PubMed Central (United Kingdom)

Background:The cardiac sodium–calcium exchanger (NCX1) is a key sarcolemmal protein for the maintenance of calcium homeostasis in the heart. Since heart failure...Full Text Available

UK PubMed Central (United Kingdom)

Germ cell tumor development in humans has been proposed to be part of testicular dysgenesis syndrome (TDS), which manifests as undescended testes, sterility, hypospadias, and, in extreme cases,...Full Text Available

British Library Electronic Table of Contents (United Kingdom)

Abstract Objectives: This investigation reviewed experimental studies of laser irradiation of wound healing in mice and rats published from 2003 to August 2008, respectively, to assess putative stimulatory effects of this treatment. Background: Animal models, including rodents, attempt to reflect human wound healing and associated problems such as dehiscence, ischemia, ulceration, infection, and scarring. They have played a key role in furthering understanding of underlying mechanisms involved in impaired wound healing, and in testing new therapeutic strategies including laser irradiation. Method: Original research papers investigating effects of laser or monochromatic light therapy on wound healing in mice and rats and published from January 2003 to August 2008 were retrieved from library...

International Nuclear Information System (INIS)

Oxide superconducting thin films were irradiated with X-rays and ultra-violet (UV) light, and induced radiation effects on electrical and chemical properties were examined by transport measurement, X-ray diffraction analysis (XRD), diamagnetization measurement and X-ray photoemission spectroscopy (XPS). After irradiation for ErBa_2Cu_3O_x films with X-rays emitted from a Rh tube for 100 hours, superconductivity was remarkably damaged, destroying the zero-resistance state. The UV-light irradiation for Bi_2Sr_2CaCu_2O_x films was performed in He gas of about 500 Pa with a low pressure mercury lamp. The superconductivity was gradually degraded with the UV irradiation time up to 70 minutes. In both cases, adequate oxygen-annealing treatments restored superconductivity. The ...

International Nuclear Information System (INIS)

By polymerase chain reaction with arbitrary primer (AP-PCR), the possibility of transmission of genome instability to somatic cells of the offspring (F_1 generation) from male parents of mice exposed to chronic low-dose #gamma#-radiation was studied. Male mice 15 days after exposure to 10-50 cGy were mated with unirradiated females. Biopsies were taken from tale tips of two month-old mice progeny for DNA separation. Primer in the AP-PCR was 20-mer oligonucleotide flanking the micro-satellite locus Atplb2 on chromosome 11 of the mouse. Comparative analysis of individual fingerprints of AP-PCR products on DNA-templates from the offspring of irradiated and unirradiated male mice revealed an increased variability of micro-satellite-associated sequences in the genome of the offspring of males exposed to 25 and 50 cGy. DNA-fingerprints of the offspring of male mice ...

UK PubMed Central (United Kingdom)

The CCAAT/enhancer-binding protein β (C/EBPβ) is required for adipocyte differentiation and maturation. We have studied the role of the transcription factor, C/EBPβ,...Full Text Available

International Nuclear Information System (INIS)

CBA/Ca mice were infected by either the intravenous or intraperitoneal route with Mycobacterium microti and the subsequent changes in local macrophage populations examined. Following infection, the number of macrophages increased and they showed greater expression of both MHC Class II molecules. This response was not dependent on viability of the mycobacteria, in contrast to reports with other microorganisms such as Listeria. Studies in sublethally irradiated mice indicated that persistent antigen could give rise to a response after a period of host recovery which was radiation dose dependent. This procedure also highlighted differences in the regulation of different murine class II antigens in vivo, as seen by delayed re-expression of I-E antigens. Macrophage accessory cell function, as assessed by an in vitro T cell proliferation assay, correlated with Ia expression after fixation, but not after indomethacin treatment; ...

International Nuclear Information System (INIS)

Changes in contents of the two kinds of neuropeptides have been measured in the brains of postnatal G57BL/6J strain mice that received accumulative doses of 0, 0.05, 0.10 or 0.30 Gy respectively in utero from tritium #beta#-irradiation during the mother mice's pregnancy from the 12.5th day of gestation to the day of delivery. Dose response relationship for alteration in somatostatin content due to exposure to 0.10 Gy or above was observed, and it was also noted that 0.30 Gy could cause decrease in arginine vasopressin in hypothalamus. These results were consistent with findings in research on brain development and reflex behavior in the literature. 0.10 Gy exposure may represent a threshold for exposure to tritiated water within the range from day 12.5 of gestation to the day of delivery using change in content of somatostatin in hypophysis as a parameter.

International Nuclear Information System (INIS)

Full text: An adaptive response is a decreased biological effect induced by a priming radiation dose given prior to a challenge dose. Adaptive responses contradict the linear-nothreshold model of risk estimation. The pKZ1 mouse chromosomal inversion assay is an extremely sensitive assay for studying the mutagenic effect of low dose radiation. A non-linear dose response for chromosomal inversion has been observed in pKZ1 spleen and prostate after a single whole body irradiation with doses between 1?Gy and 10mGy. Doses between 5-10?Gy resulted in an induction in inversions and doses between 1-10mGy resulted in a reduction below endogenous inversion frequency. These results suggest that doses in the 1-10 mGy range cause host responses which overcompensate by not only preventing inversions that would normally occur as a result of the low doses of radiation but also by preventing some of the endogenous inversions that would have occurred in the absence of radiation. It ...

International Nuclear Information System (INIS)

Pearls change their color to grey by #gamma#-ray irradiation. Grey densities were determined from darkness of pearl nuclei and thickness of the pearl layers. The densities are independent of both diameters of nuclei and pearls. The fading rate increases with increasing storage temperature. The rate of fading for irradiated pearls is lower than that for natural blue pearls. Comparison of photomicrographs (x 12) for pearls irradiated and then stored at room temperature for about 6 years revealed that their surfaces are not substantially different from the surfaces of unirradiated cultured pearls, indicating that #gamma# irradiation hardly gives rise to deterioration. #gamma#-Ray irradiation is a technique for coloration of pearls. Irradiated blue pearls seem to have resistivity to fading and to deterioration of the surface, if pearls have been ...

Energy Technology Data Exchange (ETDEWEB)

In searching modulators of immunity and hematopoiesis among natural products, being used as foods, six herbs exhibited lymphocyte proliferation in vitro, and six exhibited augmentation of hematopoietic cell growth. The combined treatments showed synergistic effects of lymphocyte proliferation and of hematopoietic cell growth. On the other hand, we found four effective oriental medicinal prescriptions, used as energy tonic or blood-building decoctions, for survival and regeneration of hematopoietic cells and for protection of stem cells of intestinal crypt in irradiated mice. On the basis of these results, extracts from combinations of herbs were made in expectation of higher effects in the three respects. In immuno modulation activity by the two combinations of herbs was confirmed in mice. In culture of bone narrow cells, growth improvement of non-adherent precursor and induction of cytokine expression by herb mixture ...

Energy Technology Data Exchange (ETDEWEB)

As part of a combined study of the responses of the mouse adrenal gland and kidney to X-irradiation, the weight of adrenal glands, the relative volumes of the cortex and medulla and the aldosterone output were measured at predetermined times after irradiation of the left organs only.

International Nuclear Information System (INIS)

The effect of irradiation using several doses of X- and #gamma#-rays (10, 20, 40, 60, 80 and 100 kGy), upon total phenolic compounds contained in the leaves of Maytenus aquifolium Martius (Celastraceae) 'espinheira santa', was investigated. The content of phenolic compounds (measured by the Folin-Denis spectrophotometric method) was unaffected by X- or #gamma#-ray irradiation, at any dose. (author)

International Nuclear Information System (INIS)

The distribution of lead in lactating mice and suckling offspring was studied with whole body autoradiography at 4 and 24 h after a single intravenous injection of "2"0"3Pb (50 mmol Pb/kg) to the dams. In the lactating mice on day 14 of lactation, the highest uptake of radioactivity at 4 h after administration was recorded in renal cortex, skeleton and liver. A high uptake was also evident in the mannary gland. At 24 h after administration, the radioactivity had decreased in most organs except in the skeleton. In the suckling pups, exposed to lead only via dams' milk for 24 h, the highest level of radioactivity was present in the intestinal mucosa and a much lower level of radioactivity was present in the skeleton. The mammary glands from mice given three daily intravenous injections of 240 #mu#mol Pb/kg were examined with X-ray microanalysis. At 4 h after the last injection, lead was found associated ...

International Nuclear Information System (INIS)

In-reactor testing of bolt-loaded compact tension specimens was performed in 360 C water. New data confirms previous results that high irradiation levels reduce SCC resistance in Alloy X-750. Low boron heats show improved IASCC (irradiation-assisted stress corrosion cracking). Alloy 625 is resistant to IASCC. Microstructural, microchemical, and deformation studies were carried out. Irradiation of X-750 caused significant strengthening and ductility loss associated with formation of cavities and dislocation loops. High irradiation did not cause segregation in X-750. Irradiation of 625 resulted in formation of small dislocation loops and a fine body-centered-orthorhombic phase. The strengthening due to loops and precipitates was apparently offset in 625 by partial dissolution of #gamma# precipitates. Transmutation of boron ...

Energy Technology Data Exchange (ETDEWEB)

The structural variations of amorphous metals, such as Pd/sub 80/Si/sub 20/, with irradiation of helium ion, neutron, and gamma ray have been mainly pursued by the method of X-ray diffraction and thermal analysis. It should be noticed that the amorphous metals show a radiation resistance, that is, no remarkable structural changes under helium ion, neutron, and gamma ray irradiation.

International Nuclear Information System (INIS)

The decree refers to conditions of irradiation of food and its components for radappertization and radurization using gamma radiation from cobalt 60 or cesium 137, X radiation or electron beam up to maximum total medium absorbed dose 10 kGy.

UK PubMed Central (United Kingdom)

Although trefoil factor 1 (TFF1; previously named pS2) is abnormally expressed in about 50% of human breast tumors, its physiopathological role in this disease has been poorly studied. Moreover,...Full Text Available

UK PubMed Central (United Kingdom)

Background and purpose:Theoretically, three α₁-adrenoceptor subtypes can interact at the signalling level to alter vascular contraction or at the molecular level...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

In this study, the effects of 325nm wavelength ultraviolet light irradiation on pitting corrosion behavior of type 340 stainless steel in a neutral chloride solution are studied. Further, the change of passive film with the light irradiation is analyzed using x-ray photoelectron spectroscopy. The mains results obtained therefrom are stated below. Pitting potential can be shifted in noble direction by the ultraviolet light irradiation. The effect of ultraviolet light irradiation is ore prominent in the pitting corrosion process than that in the passive film formation. The result of the analysis in terms of the birth and death stochastic probability process shows that pitting corrosion rate is decreased remarkably by the ultraviolet light irradiation at the formation of passive film, while the repassivation is slightly expedited by the ultraviolet light ...

International Nuclear Information System (INIS)

The activity of tyrosine aminotransferase (TAT) in the liver of mice subjected simultaneously to ionizing radiation and to local inflammatory process showed in the first 24 hours of the experiment statistically significant changes resulting from summation of the harmful effects of both factors. In the second 24-hour period an evident tendency was observed for return of a normal circadian rhythm of the enzyme. This points to presence of an endogenous mechanism of suppression of the manifestations of significant desynchronization of the circadian rhythm. The paper contains also a trial of mathematical analysis of changes in TAT activity in the circadian rhythm, a description and analysis or the suppression process, qualitative and quantitative determination of the phenomenon of cumulation of the effects of powerful stress factors acting on the animal organism. The obtained results were compared with the results of investigations of TAT activity changes obtained in ...

International Nuclear Information System (INIS)

Radioactive particles as well as x irradiation from an external source has been used in the treatment of rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis. In order to clarify effects of ionizing irradiation on synovial cells, radioactive gold ("1"9"8Au) and yttrium ("9"0Y) were added to fibroblast cultures derived from human synovial membranes. Other cultures were irradiated by a Picker x-ray machine. Fibroblast growth and hyaluronic acid production were measured. Radioactive gold and yttrium particles induced a significant increase of hyaluronic acid synthesis rate (pg/cell/day) and inhibited fibroblast growth. Fibroblasts continued to overproduce hyaluronic acid and to show growth inhibition 3 weeks after irradiation with radioactive gold. Hydrocortisone inhibited hyaluronic acid overproduction induced by radioactive gold. Overproduction of ...

International Nuclear Information System (INIS)

We report on measurements of radiation hardness of the plastic scintillating fiber SCSF-81. Fibers were irradiated with "6"0Co #gamma#-rays and fast neutrons up to 105 Gy and up to 5 x 1013 n/cm"2, respectively. Deterioration of the attenuation length of the scintillating fiber was studied. Some significant deterioration was observed at the integrated dose of about 1 x 103 Gy and at the integrated neutron flux (neutron fluence) of about 1 x 1012 n/cm"2 for #gamma#-ray and neutron irradiation, respectively. (author).

International Nuclear Information System (INIS)

Type 316 stainless steel is the primary candidate austenitic structural material for fusion first wall constructions. Here, type 316L(N) stainless steel plate material has been irradiated up to 10 dpa at temperatures of 80, 225, 325, and 425 C in the High Flux Reactor (HFR) of Petten. Tensile tests have been performed in the temperature range from RT to 575 C at a conventional strain rate of 5 x 10"-"4 s"-"1. The results of the tensile tests are analyzed in terms of irradiation hardening and loss of ductility due to irradiation. Tensile properties saturate in the early stage (within 0.65 dpa) at the lowest applied irradiation temperature. It is indicated that the most severe degradation of tensile ductility occurs in the temperature range of 275 to 350 C. Comparison with literature data revealed a large scatter in irradiation hardening at ...

Science.gov (United States)

Amorphous Pd/sub 80/Si/sub 20/ was irradiated with fast neutrons (>1 MeV) to a fluence of 5 x 10/sup 20/ neutrons/cm/sup 2/. X-ray scattering intensities were measured before and after the irradiation with monochromatic Cu-K..cap alpha../sub 1/ rays. Scattered intensities for s>0.4 A/sup -1/ (s=2 sintheta/lambda) proved unaffected, while intensities were found remarkably enhanced for s<0.4 A/sup -1/ after the irradiation, i.e., in the small-angle region and the leading edge of the first halo. The results are discussed in relation to the structural anomalies in amorphous solids.

Energy Technology Data Exchange (ETDEWEB)

Previous behavioral and pharmacological studies have implicated endorphins in radiation-induced locomotor hyperactivity of the C57BL/6J mouse. However, the endogenous opiate(s) responsible for this behavioral change have not been identified. The present study measured beta-endorphin-like immunoreactivity (beta-END-LI) in brain, blood, and combined brain and pituitary samples from irradiated and sham-irradiated C57BL/6J mice. After radiation exposure, levels of beta-END-LI decreased significantly in the brain. A similar, but not statistically significant, decline was measured in combined brain and pituitary samples. Concentrations of blood beta-END-LI were not changed by irradiation. These radiogenic changes in beta-END-LI are in some ways similar to those observed after other stresses. However, radiation-induced locomotor hyperactivity may be mediated more by alterations of beta-END-LI in the brain than ...

International Nuclear Information System (INIS)

In-reactor testing of bolt-loaded compact tension specimens was performed in 360 C water to determine the irradiation-assisted stress corrosion cracking (IASCC) behavior of HTH Alloy X-750 and direct-aged Alloy 625. New data confirm previous results showing that high irradiation levels reduce SCC resistance in Alloy X-750. Heat-to-heat variability correlates with boron content, with low boron heats showing improved IASCC properties. Alloy 625 is resistant to IASCC, as no cracking was observed in any Alloy 625 specimens. Microstructural, microchemical and deformation studies were performed to characterize the mechanisms responsible for IASCC in Alloy X-750 and the lack of an effect in Alloy 625. The mechanisms under investigation are: boron transmutation effects, radiation-induced changes in microstructure and deformation characteristics, and radiation-induced segregation. ...

KoreaScience (Korea)

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KoreaScience (Korea)

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Energy Technology Data Exchange (ETDEWEB)

Changes in the phosphate metabolism of the transplanted SCCVII (squamous cell carcinoma VII) tumor were studied before and after irradiation using in vivo [sup 31]P-magnetic resonance spectroscopy (MRS). Phosphocreatine (PCr), [gamma]-, [alpha]-, [beta]-ATP, inorganic phosphate (Pi), phosphomonoester (PME), and phosphodiester (PDE) were detected in [sup 31]P-MR spectra of tumor tissues. The curve fitting method was employed for calculating each peak of [sup 31]P-MR spectra (PCr, [beta]-ATP, Pi, PME, PDE). The values of PCr, PCr/Pi, [beta]-ATP/Pi and pH decreased in proportion to the growth of tumor, whereas that of Pi, PME and PDE increased. But the changes of [beta]-ATP were minimal in degree. Based on the fact that the ratio of PCr/Pi highly correlated with tumor volume and showed the most remarkable change among various parameters, it might be the useful index for the tumor growth. Because the phospholipid metabolite PME was detected in the earlier stage of ...

Energy Technology Data Exchange (ETDEWEB)

Chicken embryos were x-irradiated in ovo with 5-30 cGy (=priming dose) at the 13th-15th day of development. After 3-48 h, brain- and liver-cell suspensions were x-irradiated in vitro with (challenge) doses of 4-32 Gy. Significantly less radiation damage was observed when the radiation response was measured by scheduled DNA synthesis, nucleoid sedimentation and viscosity of alkaline cell lysates 12-36 h after the priming exposure. In vivo, pre-irradiation with 10 cGy enhanced regeneration as evidenced by the DNA content of chicken embryo brain and liver 24 h following a challenge dose of 4 Gy. From nucleoid sedimentation analyses in brain and liver cells immediately after irradiation with 16 Gy and after a 30-min repair period in the presence of aphidicolin, dideoxythymidine and 3-aminobenzamide or in the absence of these DNA repair inhibitors, it is concluded that a reduction of the initial radiation ...

Energy Technology Data Exchange (ETDEWEB)

The short range of low-energy electrons has made them suitable for the treatment of skin lesions, especially when extensive areas must be irradiated with special considerations to save the normal underlying tissue. This report covers some salient features of total body electron irradiation: the construction of the large fields required, x-ray contamination levels, and multiple-field techniques. While the investigation is essentially experimental, we also indicate the results of calculations. We conclude most generally that treatment planning with whole skin irradiations can be as precise as with smaller fields.

Energy Technology Data Exchange (ETDEWEB)

{sup 188}Re is a {beta}{sup -} (Emax=2.12 MeV) and {gamma} (155 keV) emitter. Since its chemistry is similar to that of the largely employed tracer, {sup 99m}Tc, molecules of hyaluronic acid (HA) have been labelled with {sup 188}Re to produce a target specific radiopharmaceutical. The radiolabeled compound, i.v. injected in healthy mice, is able to accumulate into the liver after a few minutes. To study the effect of metabolic radiotherapy in mice, we have built a small gamma camera based on a matrix of YAP:Ce crystals, with 0.6x0.6x10 mm{sup 3} pixels, read out by a R2486 Hamamatsu PSPMT. A high-sensitivity 20 mm thick lead parallel-hole collimator, with hole diameter 1.5 mm and septa of 0.18 mm, is placed in front of the YAP matrix. Preliminary results obtained with various phantoms containing a solution of {sup 188}Re and with C57 black mice injected with the {sup 188}Re-HA ...

International Nuclear Information System (INIS)

Four unique deisgn features are described which make the Fast Flux Test Facility eminently suitable for irradiation test programs. These features are a fast flux level of 7 x 10"1"5 neutrons/cm"2/sec, a 36-inch reference (breeder reactor) core height, test volumes suitable for testing of statistical quantities of materials, and the capability for direct (contact) or indirect (proximity) instrumentation of active core experiments.

International Nuclear Information System (INIS)

The radiation properties of the #alpha# emitter "2"1"1At are in favor of its application malignant tumor therapy. As a basis for further investigations the biokinetics of At"-, At x H_2O, At I_2"-, and [At(thio)_2]"+ were determined after i.v. injection into healthy and tumor-bearing mice. The estimation of the ion mobility of the carrier-free compounds allowed the use of uniquely characterized initial compounds. The organ distribution of all species examined was similar to the distribution of astatide. Accumulation was found in the thyroid and other inner organs. (author).

International Nuclear Information System (INIS)

The presence of washed or unwashed cellophane alone or together with a bleomycin, mitomycin C or hydrochlorothiazide, ('Esidrex') showed no appreciable effect on survival of either unirradiated or irradiated conidia. Irradiation for a period of 20min reduced the survival of conidia to 20%. The growth of irradiated conidia in the presence of bleomycin, mitomycin C or Esidrex is associated with a 2- to 3-fold increase in the frequency of gene convertants, but was not accompanied by an increase in point mutants. When conidia were grown on cellophane but otherwise treated as before the frequency of gene convertants was increased 8-fold, but induction of point mutants was negligible. This effect was the same for irradiated and unirradiated conidia. The environment created by the cellophane in contract with the medium appears to affect the action of each of the three compounds synergistically. (author).

International Nuclear Information System (INIS)

The effect of both dopant and neutron radiation on the optical and thermal properties of polyvinyl chloride (PVC) has been studied. The doped samples with Pb and Cd were irradiated with a 14 MeV-neutron fluence in the range 7-28.8 x 10"9 n/cm"2. The optical energy gap E_o_p exhibits a significant dependence on the type of additive and the neutron irradiation fluence. The specific heat at constant pressure C_p showed a nonmonotonical change with radiation fluence. The results of this study show that PVC:Pb behaves as a crystalline structure which is only slightly affected by neutron irradiation, while PVC:Cd is highly affected. (author).

International Nuclear Information System (INIS)

The influence of irradiation with 2.6 MeV H and He nuclei on the superconducting properties (critical temperature Tsub(c), critical current Isub(c)) of the intermetallic compound Nb_3Sn was studied. Irradiation led to a significant lowering of Tsub(c), while Isub(c) is increasing with the radiation dose. This is assumed to be due to the formation of active pinning centres in the lattice. There is a fast drop of Isub(c) after a peak value has been reached. Annealing of the samples (600-1,000"0C) led to an almost complete recovery of the initial value of Tsub(c). X-ray diffraction showed that irradiation causes considerable distortions of the lattice while the A15 crystal structure is retained. The causes of the radiation effects related to structural defects are discussed. (GSCH).

International Nuclear Information System (INIS)

The ductile-brittle transition behavior of neutron-irradiated welded A533B C1.1 steel has been studied by means of small specimen test technique for discussing the specimen size effects on the impact properties. Standard size, one-third size and 1.5 mm size Charpy V-notch specimens were prepared. Neutron irradiation was performed in JMTR with fluencies up to 0.75 and 1.3x10"2"4 n/m"2 (E > 1 MeV). Normalization of the USE is done by a curve fitting method and the USE of different size of specimens can be expressed by the equation; E=a x B"n, where a is a constant and n is an exponent. There observed linear relationships between DBTTs obtained using standard and sub-sized specimens. (author)

International Nuclear Information System (INIS)

The transport properties of a 'thin' polycrystalline diamond film are analyzed after the sample exposure to 8.06-keV x-ray radiation. Structure and morphology of the as-grown film have been evaluated by Raman, x-ray diffraction, and scanning electron microscopy techniques. The transport properties have been investigated by measuring dark current-voltage characteristics in the temperature range of 60 to 360 K. Ohmic transport has been evidenced on the as-grown film up to 1.16x10"5 V/cm. After irradiation, nonlinear contributions to the dark current have been evidenced and related to field-assisted thermal ionization of traps. Below 200 K, hopping mechanisms have been observed. Correlations have been found among x-ray irradiation, density of traps involved in the transport processes, and the nonhomogeneous nature of the sample. A simple model of the grain boundary ...

International Nuclear Information System (INIS)

The present work is to study effects of neutron irradiation on the structure of amorphous Pb_8_0 Si_2_0 and Pd_7_7_._5 Cu_6 Si_1_6_._5 alloys by using X-ray diffraction techniques. differential scanning calorimertry (DSC) and internal friction measurements. The irradiation will produce obvious changes in the pair correlation function g(r) and radial distribution function RDF (r). The increase of crystallization temperature (Tx) and enthalpy of two specimens were found by DSC measurements after irradiation. The results of internal friction measurement show that the internal friction of the irradiated Pd_8_0Si_2_0 alloy is higher than that of the unirradiated in the temperature range of Tirradiation are discussed in terms of the concepts of density fluctuation defects (p) and shear stress fluctuation defects ...

International Nuclear Information System (INIS)

Early effects of 100 Kilorads of X-rays on muscle cell membrane properties have been measured in sartorius muscles from Leptodactylus ocellatus. Threshold strength for rectangular current pulses increased 10% after irradiation, and action potential propagation velocity decreased 10%. Passive membrane parameters were calculated from potential responses to sub-threshold current pulses, assuming conventional cable theory. Specific membrane conductance increased to 18% after irradiation, membrane capacitance increased 14%, and length constant decreased 10% but membrane time constant was unchanged. Cell diameter decreased 5%, and resting membrane potential decreased 8%. Membrane parameters during an action potential were also evaluated by the phase-plane and current-voltage plot techniques. Irradiation significantly decreased the action potential amplitude, the excitation potential, and the maximum rates of ...

British Library Electronic Table of Contents (United Kingdom)

Olfactory memory dysfunctions were investigated in the triple-transgenic murine model of Alzheimer's disease (3x Tg-AD). In the social transmission of food preference test, 3x Tg-AD mice presented severe deficits in odor-based memory, without gross changes in general odor-ability. Ab and tau immunoreactivity was not observed in the primary processing regions for odor, the olfactory bulbs (OBs), whereas marked immunostaining was present in the piriform, entorhinal, and orbitofrontal cortex, as well as in the hippocampus. Our results suggest that the impairment in olfactory-based information processing might arise from degenerative mechanisms mostly affecting higher cortical regions and limbic areas, such as the hippocampus.

Science.gov (United States)

A radioactive particle was analyzed to discover the composition of the inactive material of the particle. The method uses the x-ray line spectrum of the K series caused by electron irradiation of the particle in the electron microscope. Iron and aluminum or silicon (the last two could not be distinguished) were found as inactive components in the particle. (D.L.C.)

International Nuclear Information System (INIS)

The results of an investigation into tailed nuclei (TN) and features of dose dependence on frequency of the binuclear cells with TN in human lymphocyte cultures by cytogenetic block method upon X-ray radiation dose are presented. The frequencies of metaphases with dicentric and ring chromosomes are investigated concurrent with TN formed upon completion of first postradiation mitosis. Frequency of the appearance of binuclear cells with nuclei having outgrowth into the cytoplasmic space and arises after first mitosis in human lymphocyte culture is linear-square dependent on the X-irradiation at doses from 0.0 to 4.0 Gy. Positive correlation between frequency of cells with tailed nuclei and frequency of metaphases of first mitosis having dicentric and rings was established. Apparently, formation such TN is connected with dicentric and rings

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A study was carried out to determine optimum decontamination dose for a locally manufactured coconut cream powder. Samples were gamma irradiated (0-15 kGy) and ageing process was achieved using GEER oven at 60 deg. C for 7 days, which is equivalent to one-year storage at room temperature. Iodine value (IV), ranging from 4.8 to 6.4, was not affected by radiation doses and storage, however peroxide value and thiobarbituric acid (TBA) generally increased with radiation doses. In most samples, peroxide value (meq/kg) reduced after storage, whilst the TBA (mg malonaldehyde/kg), indicator for product quality, slightly increased. The sensory evaluation conducted using 25 taste panellists indicated that scores on odour, creamy taste and overall acceptance for all irradiated samples at more than 5 kGy were significantly lower (P<0.05) than the control. However, the panellists could not detect any significant differences among the ...

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The effect of the heavy particle irradiation on cell survival is different from that of X-ray irradiation. In Japan, heavy particles will be applied to cancer patients in the near future. This study was performed to determine the effect that carbon particle irradiation exerts to human monolayer cells in vitro, in comparison with the effect of 200 kVp X-ray. Two human cell lines, HeLaS3 and RMUG, were used. The irradiation was carried out by the RIKEN ring cyclotron and 200 kVp X-ray. The experimental procedure is explained. Also split dose experiment was carried out by applying equally divided doses at intervals of 2 - 4 hours. The Bragg curve of 135 MeV/n carbon beam through the lucite plates with different thickness is given. Thus the different LETs were obtained. The survival curves for 200 kVp X-ray and the various ...

UK PubMed Central (United Kingdom)

BackgroundThe scent from receptive female mice functions as a signal, which stimulates male mice to search for potential mating partners. This searching behavior is coupled with...Full Text Available

UK PubMed Central (United Kingdom)

Plasma samples were collected from mice infected with Trypanosoma musculi at different times postinfection and administered to naive recipient mice either before or during T. musculi infection. The...Full Text Available

International Nuclear Information System (INIS)

Cerium is known to enter substitutionally in trivalent state when doped in alkali halides. Cerium doped NaCl crystals exhibit greatly enhanced thermoluminescence output upon X-irradiation at RT, the intensity of emission being about 10 times that in undoped crystals for similar dosage of irradiation. The cerium doped crystals give upon X-irradiation a very intense glow peak at 145degC with shoulders at 120degC and 210degC. Upon partially bleaching the crystal with F-light, the peak at 120degC becomes prominent probably due to faster bleaching of the glow at 145degC. From further optical bleaching studies, it is concluded that the glow peak at around 120degC is due to cerium centres in the irradiated crystal and the 145degC peak due to F centres. This F centre emission occurs at lower temperature, compared to that in the undoped crystals where it occurs at around 180degC. The spectral emission in the Ce ...

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Aluminum nitride has been proposed as electrically insulating coating in connection with blankets made of vanadium alloys. Irradiations were performed with an applied DC electric field of 100 kV/m, using a 104 MeV {alpha}-particle beam. The dose achieved were 0.1 dpa at 300 C, 0.05 dpa at 400 C, and 0.06 dpa at 500 C. The out-of-beam conductivity {sigma}{sub 0} decreased at all temperatures employed during early stage of irradiation. Before 0.02 dpa had been reached, {sigma}{sub 0} dropped to low values of typically (2-4) x 10{sup -11} ({Omega} m){sup -1}. Although a moderate increase can be observed during further irradiation, {sigma}{sub 0} remained below the initial value of the unirradiated specimen for all temperatures. That is, there is no significant evidence for radiation induced electrical degradation. The in-beam conductivity {sigma}, measured continuously during ...

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The High Exposure Facility is a collimated high-level gamma irradiator that is located in the basement of the 318 building. It was custom developed by PNNL back in 1982 to meet the needs for high range radiological instrument calibrations and dosimeter irradiations. At the time no commercially available product existed that could create exposure rates up to 20,000 R/h. This document is intended to pass on the design criteria that was employed to create this unique facility, while maintaining compliance with ANSI N543-1974, "General Safety Standard for Installations Using Non-Medical X-Ray and Sealed Gamma-Ray Sources, Energies up to 10 MeV."

International Nuclear Information System (INIS)

Lead is known to enter substitutionally in divalent state when doped in alkali halides. When irradiated at room temperature these lead centers (Pb"+"+) act as traps for electrons knocked off from the halogen ions and become Pb"+ and Pb"0 (for large doses of irradiation). These changes could be followed in the optical absorption studies. These lead-doped crystals after X-ray irradiation yield a thermoluminescence output smaller than that observed in 'pure' crystals. However, two new glow peaks are observed in additions to those due to F-centers. In KCl : Pb and Kbr : Pb crystals part of the F-center glow preceds the new glow peaks. The new peaks are attributed to the Pb"+ and Pb"0 centers. The glow peak temperatures and trap depths for these peaks an obtained by total-curve fitting method are reported. (author).

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Hyperquenching of liquid water with cooling rates of 10{sup 6}-10{sup 7} K s{sup -1} yields glassy water. Upon {gamma}-irradiation at 77 K, the only paramagnetic species accumulating in hyperquenched glassy water are the hydroxyl and hydroperoxyl radicals. There are no hydrogen atoms or electrons seen by the ESR technique. For irradiation doses up to about 70 kGy, the relative contributions of hydroxyl and hydroperoxyl radicals to the total amount of paramagnetic species remain virtually constant. The total amount of paramagnetic species, n, is sublinear in dose, d, well approximated by n=8.55x10{sup 16}d{sup 0.8} for n in spin g{sup -1} and d in kGy.

International Nuclear Information System (INIS)

The effects of modification with Ti and Nb, heat treatment and solute segregation on void suppression in 316 stainless steel were studied using HVEM in the temperature range of 623-873 K after solution treatment at 1323-1473 K. Post-irradiation compositional analysis was performed by an energy dispersive X-ray analyzer. In Ti-modified stainless steel, void swelling peaks appeared at 723 K and 823 K. On the other hand, when the stainless steels modified by both Ti and Nb were irradiated, the void swelling was effectively suppressed, particularly the growth rate of a void was remarkedly retarded. This void suppression effect was easily recognized with increasing Nb concentration. Compositions such as Mo, Cr, Ti and Ni changed during irradiation and Ni, Si and Ti enriched around voids, whereas Cr and Mo depleted. (orig.).

British Library Electronic Table of Contents (United Kingdom)

Abstract We prepared BiOCl1-xBrx (x=0-1) solid solutions and characterized their structures, morphologies, and photocatalytic properties by X-ray diffraction, diffuse reflectance spectroscopy, scanning electron microscopy, Raman spectroscopy, photocurrent and photocatalytic activity measurements and also by density functional theory calculations for BiOCl, BiOBr, BiOCl0.5Br0.5. Under visible-light irradiation BiOCl1-xBrx exhibits a stronger photocatalytic activity than do BiOCl and BiOBr, with the activity reaching the maximum at x=0.5 and decreasing gradually as x is increased toward 1 or decreased toward 0. This trend is closely mimicked by the photogenerated current of BiOCl1-xBrx, indicating that the enhanced photocatalytic activity of BiOCl1-xBrx with respect to those of BiOCl and BiO...

International Nuclear Information System (INIS)

Full text of publication follows: The effect of neutron irradiation on the thermal conductivity of silicon carbide can be dramatic depending on the irradiation temperature and fluence the material is subjected to, and may be a critical factor defining it's use in fusion systems. Historically there have been several papers describing the effect of neutron irradiation on thermal conductivity degradation of SiC, predominately in the low to intermediate temperature ranges. Practically all of this work has been at temperatures lower than the application temperature for SiC being considered by the conceptual fusion reactors. This paper provides new data on the thermal conductivity of high quality CVD silicon carbide irradiated in a range of doses and temperature spanning the proposed fusion reactor temperature range. Specifically, an irradiation was carried out from fractions milli-dpa to ...

Science.gov (United States)

N-ethyl-N-nitrosourea (ENU) mutagenesis has led to the elucidation of several regulator genes for melanocyte and skin development. Here we characterized a mutant from ENU mutagenesis with similar phenotype as that of Splotch mutant, including exencephaly, spina bifida and abnormal limbs in homozygotes as well as white belly spotting and occasionally loop-tail in heterozygotes. This novel mutant was named as Sp(xG). Through genome-wide linkage analysis in backcross progenies with microsatellite markers, the Sp(xG) was confined to a region between D1MIT415 and D1MIT7 on chromosome 1, where notable Pax3 gene was located. Direct sequencing revealed that Sp(xG) carried a nucleotide A894G missense transition in exon 6 of Pax3 gene that resulted in Asn to Asp substitution at amino acid 269 within the highly-conserved homeodomain (HD) DNA recognition module, which was the first point mutation found in this domain in ...

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Consensus principles from radiation biology were used to describe a generic set of nonlinear, first-order differential equations for modeling of toxicity-induced compensatory cell kinetics in terms of sublethal injury, repair, direct killing, killing of cells with unrepaired sublethal injury, and repopulation. This cellular model was linked to a probit model of hematopoietic mortality that describes death from infection and/or hemorrhage between {approximately} 5 and 30 days. Mortality data from 27 experiments with 851 doseresponse groups, in which doses were protracted by rate and/or fractionation, were used to simultaneously estimate all rate constants by maximum-likelihood methods. Data used represented 18,940 test animals distributed according to: (mice, 12,827); (rats, 2,925); (sheep, 1,676); (swine, 829); (dogs, 479); and (burros, 204). Although a long-term, repopulating hematopoietic stem cell is ancestral to all lineages needed to restore normal ...

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Mitotic delay is described as a classical response to radiation; however, circadian rhythmicity in cell division in vivo has not been considered by many authors. The present study investigated the relation between fluctuations reported as mitotic delay and recovery in vivo and circadian oscillations in mitotic index in mouse corneal epithelium. One aspect involved single doses (approximately 600 rad) given to mice at different circadian stages. The normal circadian rhythm in cell division was never obliterated. Inhibition of mitosis was evident but unpredictable, ranging from 6 to 15 hr after irradiation. Recovery was evident only during the daily increase in mitotic index of controls. The classical interpretation of recovery from mitotic delay may be in an in vitro phenomenon not reflecting in vivo responses, which are apparently strongly circadian stage dependent. The second portion of the study demonstrated a dose-response effect on length ...

KoreaScience (Korea)

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KoreaScience (Korea)

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International Nuclear Information System (INIS)

The effect of X-irradiation on production of MUC1 was studied with human colon carcinoma HT-29 cells. As evaluated by immunocytochemical staining, the percentages or MUC1-positive cells in cells at 4 days after 6 Gy irradiation and in unirradiated control cells were 52#+-#3.5% (n=6) and 26#+-#2.8% (n=6), respectively. Flow-cytometric analysis of living cells showed that MUC1 began to rise from day 1, reaching a plateau by day 4 after 6 Gy irradiation. Western blot analysis with monoclonal antibody MY.1E12 against glycosylated MUC1 (mature form) showed dose-dependent increases of two bands (500 and 390 kDa) corresponding to two polymorphic MUC1 alleles. Premature forms of MUC1 (350 and 240 kDa) were detectable with monoclonal antibody HMFG-2 only in irradiated cells, suggesting that new core protein synthesis had been induced. The transcriptional activity of the MUC1 gene was analyzed in terms of ...

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Thirty-nine previously untreated patients with squamous cell carcinoma of the tongue were treated by irradiation or a combination of irradiation and surgery, with or without chemotherapy, between January 1971 and December 1980. All of the patients had a follow-up period of at least nine years. Twenty-two patients were men and 17 were women. The average age was 50.1 years, with a range of 30 to 74 years. The absolute five-year survival rate was 82.1% and the cumulative ten-year survival rate 76.9% for these 39 patients. Cervical node metastases were clinically found on admission in 14 patients whose five-year survival rate was 64.3%, whereas it was 92.0% for 25 patients without metastasis. The absolute five-year survival rate decreased from 92.3% for patients with stage I lesions to 90.9%, 87.5% and 42.9% for those with stage II, stage III and stage IV lesions, respectively. Most of the patients received external irradiation ...

Energy Technology Data Exchange (ETDEWEB)

The electrical conductivity of Vitox-alumina (99.2%), Wesgo-alumina (99.9%) and AlN (99.6%) has been measured during and after irradiation with an experimental set-up which allows fusion relevant loading conditions. All irradiations were performed in high vacuum at 450 C using a 104 MeV {alpha}-particle beam with an applied DC electric field of 100 kV/m. In the high purity Vitox-alumina the in-situ and postirradiation bulk conductivities {sigma} and {sigma}{sub 0} show the highest irradiation induced electrical breakdown ever observed. The saturation level near 4 x 10{sup -2} ({Omega}m){sup -1}, reached already after 0.015 dpa (O-sublattice), is already above the critical value necessary to avoid MHD pressure drop with 10 {mu}m coatings in flowing liquid metal coolants. Under the same conditions no radiation induced electrical degradation at all has been found in Wesgo-alumina and AlN. (orig.).

International Nuclear Information System (INIS)

Full text: The surface properties of poly (tetrafluoroethylene) (PTFE) are changed by the exposure to synchrotron radiation (SR). We succeeded in controlling the wettability of the PTFE surface from hydrophobic to hydrophilic by varying the substrate temperature during the SR irradiation and found that the wettability was ascribable to microstructure and chemical composition of surface.In these previous works, oxygen atoms were found to inhabit on the hydrophobic surface of PTFE. In this study, we investigated the surface modification of PTFE from the SR exposure experiment under the O_2 gas atmosphere. The SR exposure to the PTFE sheet was carried out at beamline 6 (BL6) of the New- SUBARU. The PTFE sheet was irradiated to the white beam, ranging 50-1000 eV at BL6 at room temperature. The gas cell was mounted at the irradiation chamber. The O_2 gas pressure in the gas cell can be maintained at about 0.20 Pa during the SR ...

International Nuclear Information System (INIS)

The objective of this study is to evaluate the lifetime of Zr-2.5Nb pressure tube at Wolsung Unit-1. The testing materials (Effective full power year: 9.3 year, Accumulated nuetron fluence: 7.66#approx#8.91 x 1025 n/m"2) were sampled from M-11 tube at various position(inlet, middle and outlet). The cutting was carried out at hot cell to fabricate CT(Compact tension) specimen with 48 ppm hydrogen content. In the result of DHC test, irradiation-damaged specimen showed 4#approx#6 times faster DHC velocity(5.298E-0.8#approx#7.039E-8 m/s: 182 .deg. C) than non-irradiated specimen. These DHCV results also show slight faster than one of specimen from Pickering plant (average DHCV: 4.5E-8 m/s: 182 .Deg C). This faster DHCV can be explained with the fact that Wolsung Unit-1 have been operated in a severe conditions(higher cooling water temperature, high power and efficiency) than Pickering one. The striation spacing which was seen ...

International Nuclear Information System (INIS)

Irradiation of the human body in diagnostic X-ray procedures results in different absorbed doses in the various body organs. A somatic dose index in formulated by applying the relative sensitivity of the human to each of the most important somatic effects and utilizing the absorbed dose in the affected organs. This quantity is used to convey a cumulative somatic impact and is computed for common radiographic views in diagnostic radiology as a function of beam quality for a nominal IR entrance exposure. Using typical X-ray beam qualities and exposures, the frequency of the various radiographic views that make up an examination and the frequencies of the various examinations in the national population, illustrative examples of the application of the somatic dose index are presented. (author).

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Using {gamma}-irradiation-induced reduction in the field of a {sup 60}Co {gamma}-ray source, colloidal silver and gold nanoparticles were prepared from their corresponding metal salts in aqueous solution and compared with those by chemical reduction. The radiation-based method provided silver nanoparticles with higher concentration and narrower size distribution than those obtained by chemical reduction method while there was no significant difference between the two strategies for the preparation of gold nanoparticles. {gamma}-Irradiation of 1.0 x 10{sup -3} M AgNO{sub 3} solution resulted in nearly 100 times more highly concentrated silver colloids than those by citrate reduction. Furthermore, the radiation method could lead to more highly concentrated silver colloids by simply increasing the concentration of AgNO{sub 3} solution up to 2.0 x 10{sup -2} M. The two metal nanoparticles prepared by the ...

International Nuclear Information System (INIS)

Nuclear radiation detectors in integral execution were produced by successive epitaxial growth from vapor phase of Zn Te and Cd Se thin layers onto scintillating Zn Se (Te) crystals. The irradiation of combined Zn Se (Te) - Zn Te - Cd Se detectors by Cu_K_a X-rays leads to the appearance of photoreceiver e.m.f., which tends to saturation with the increase of X-ray radiation dose reaching the value of 0.34-0.40 V at 200 R/min. The short circuit current dependence of irradiation dose power is linear. The matching factor for detectors with Zn Te-Cd Se photoreceivers with different doping levels is 0.68-0.92. The absolute monochromatic sensitivity is 0.32-0.35 m A/m W at a quantum efficiency 0.58-0.61 and a time constant 2 x 10"-"4 s. The calculated dose sensitivity for Zn Se(Te)-Zn Te-Cd Se combined detectors at the irradiation with X-rays ...

International Nuclear Information System (INIS)

An irradiation head with sample holders is described and measurement geometry is reported. Measurements were made for optimizing the distance between the source and the sample and for optimizing the sample diameter. The optimal distance between the source and the sample does not depend on the collimator diameter. The sample diameter should not exceed 30 - 35 mm. Sensitivity and detection limits were determined for Zn, Pb and Br and calibration curves were plotted. (M.D.) 6 figs., 2 tabs., 4 refs.

UK PubMed Central (United Kingdom)

&#x003b3;-Radiation-induced tumors of Arabidopsis thaliana L. have been produced as a novel approach to isolation of genes that regulate plant development. Tumors excised from irradiated...Full Text Available

International Nuclear Information System (INIS)

A computerised curve-fitting method was developed to calculate the trapping parameters in LiF TLD-100 and LiF:Mg, Ti. After irradiation in a "6"0Co field and with X rays emitted at different voltages the TL process is best described by first-order kinetics. A dependence of the trapping parameters on both the concentration of Mg and Ti and photon energy was detected. (author).

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DBA/2J (DBA) mice are susceptible to audiogenic seizures (ASs) in an age-dependent manner. Anion transport as measured by radioiodide uptake was determined in thyroid gland, salivary gland, skeletal muscle, cerebral cortex, cerebellum, brainstem, and CSF from these mice at various ages. Anion transport was also determined in C57BL/6J(C57) mice, an AS-resistant strain. In thyroid, DBA mice had an enhanced ability to concentrate iodide at 21 days of age when they have maximal AS susceptibility, as compared with the same-aged C57 mice. This difference in thyroid function was less marked at 40 days of age, when DBA mice are less AS susceptible, and was absent at 110 days of age, when DBA mice are AS resistant. In brain, differences in iodide uptake were also noted between these two strains of mice at 21 days of age. DBA ...

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Radioadapted chicken embryo cells (X-irradiation in ovo with 10 cGy at the 14th day of development with priming periods of 24 h) were treated in vitro by challenge doses of 14 different DNA- and/or chromatin-interactive agents, including X-rays. A decrease in the cellular damage, as measured by scheduled DNA synthesis, was only observed with X-irradiation. Sedimentation of nucleoids as well as viscosity of alkaline lysates from ethidium bromide (0.35-400 {mu}g/ml)-, vovobiocin (125-1800 {mu}g/ml)-, and hyperthermia (30 min at 43 and 45 )-treated cells suggest a higher tendency of radioadapted cells to undergo positive DNA supercoiling. When DNA from adapted and non-adapted chicken embryo cells was used as substrate, neither its digestion by DNase I nor the inhibition of DNase I activity by various DNA-interactive agents was changed in primed cells. From the previous investigations as well as from the present results it is ...

International Nuclear Information System (INIS)

Three high density polyethylene (PE) samples of different origins, with weight average molar masses ranging from 38 to 63 kg mol"-"1 and displaying a semi-ductile behavior with strain at break ?_R values of the order of 100-140%, were gamma irradiated under nitrogen for doses up to 33.3 kGy. Steric exclusion chromatography and rheometry allowed to quantify the crosslink density X. This later reached values ranging from 4.6 to 9.0x10"-"3 mol kg"-"1, i.e. situated below the gelation point. Differential calorimetry, density measurement and small angle X-rays scattering showed the absence of significant changes in the crystalline morphology, especially lamellar dimensions. Tensile testing revealed an unexpected trend towards brittle regime of fracture while yield stress increases significantly at low doses. It appeared that branching disfavors cavitation during yielding, but this effect is not favorable to ...

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In light water reactors, austenitic stainless steels (SSs) are used extensively as structural alloys in reactor core internal components because of their high strength, ductility, and fracture toughness. However, exposure to high levels of neutron irradiation for extended periods degrades the fracture properties of these steels by changing the material microstructure (e.g., radiation hardening) and microchemistry (e.g., radiation-induced segregation). Experimental data are presented on the fracture toughness and crack growth rates (CGRs) of wrought and cast austenitic SSs, including weld heat-affected-zone materials, that were irradiated to fluence levels as high as {approx} 2x 10{sup 21} n/cm{sup 2} (E > 1 MeV) ({approx} 3 dpa) in a light water reactor at 288-300 C. The results are compared with the data available in the literature. The effects of material composition, irradiation dose, and ...

International Nuclear Information System (INIS)

A family of industrial irradiators is being developed by AECL to cover an electron-beam energy range from 5 to 18 MeV at beam powers between 20 and 250 kW. The IMPELA family of irradiators is designed for push button, reliable operation. The major irradiator components are modular, allowing for later upgrades to meet increased demands in either electron or X-ray mode. Interface between the control system, irradiator availability and dose quality assurance is in conformance with the most demanding specifications. The IMPELA irradiators use a klystron-driven, standing-wave, L-band accelerator structure with direct injection from a rugged, triode electron gun. Direct control of the accelerating field during the beam pulse ensures constant output beam energy, independent of beam power. The first member of the family, the IMPELA 10/50 (10 MeV, 50 kW), is in the final ...

International Nuclear Information System (INIS)

In this paper we discuss the results of thermoluminescence (TL) studies carried out on freshly quenched crystals of KBr doped with #approx# 50 ppm of Eu"2"+ ions which were X-irradiated at room temperature. The TL glow curve of this phosphor material consists of three glow peaks at 355, 376 and 398 K whose intensities increased as a function of X-irradiation time. The TL glow peaks were analyzed by the total curve-fitting method in order to obtain the characteristic parameters; activation energy, pre-exponential factor and kinetic order. The spectral character of the emission recorded during thermoluminescence was found to be the same for all glow peaks and consists of a broad band centered at #approx# 420 nm. It is proposed that the model of the TL process most consistent with our experimental results is one in which the Eu"2"+ impurity acts as an electron trap during the irradiation process and that the radiation induced ...

British Library Electronic Table of Contents (United Kingdom)

Purpose: The DBA/2J mice have been used as an animal model for human pigmentary glaucoma. However, these mice develop various degrees of disease symptoms at different ages, making it difficult to detect pathological changes of retinal degeneration at glaucoma onset. The purpose of this study is to develop a non-invasive assay to identify individual mice that develop visual deficits. Materials and Methods: We apply two behavioral tests, a swimming test of visual discrimination and a test of optomotor response, to identify glaucomatous DBA/2J mice. We then examine whether the elevation of intraocular pressure (IOP), the common risk factor for glaucoma, affects visual performances of the DBA/2J mice. We further compare the retinal ganglion cell death, one of the signature glaucoma symptoms, i...

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Portal localization images for high-energy electron beam therapy are necessary to confirm the treatment field by comparing them with a simulation image obtained before treatment or portal verification images after treatment. In this study, portal localization images were acquired using the computed radiography (CR) system and bremsstrahlung X-rays generated in the electron beam irradiations. All images obtained with phantom and the irradiations of in the electron energy of 8, 10, 12 and 15 MeV were feasible for clinical use. The CR system used in this study included general diagnostic imaging cassette and storage phosphor plate, but none of other special devices. The system can usually supply portal localization images, which maintains the quality assurance of high-energy electron beam therapy. (author)

International Nuclear Information System (INIS)

By method of transmission electron microscopy and measuring of microhardness the peculiarities of influence of radiation defect clusters on molybdenum radiation hardening along range path of protons with 30 MeV initial energy are studied. Decrease effect of hardening growth value and even its absence depending on irradiation dose in the range of 10-20 MeV proton energies in presence of high density of radiation defect dispersed clusters is revealed. It is shown experimentally that this effect is connected with accumulation of hydrogen up to not very high concentrations (not more than 5x10"-"4 at.%) at the expense of elastic and inelastic proton scattering. 5 refs.; 5 figs.

International Nuclear Information System (INIS)

The neutron transmutation doping (NTD) method was applied to the initially p-type silicon in order to extend the NTD applications at HANARO. The relationship between the irradiation neutron fluence and the final resistivity of the initially p-type silicon material was investigated. The proportional constant between the neutron fluence and the resistivity was determined to be 2.3473x1019 n ? cm-1. The deviation of the final resistivity from the target for almost all the irradiation results of the initially p-type silicon ingots was at a range from -5% to 2%. In addition, the burn-up effect of the boron impurities, the residual 32P activity and the effect of the compensation characteristics for the initially p-type silicon were studied. Conclusively, the practical methodology to perform the neutron transmutation doping of the initially p-type silicon ingot was established.

Energy Technology Data Exchange (ETDEWEB)

No abstract prepared.

Energy Technology Data Exchange (ETDEWEB)

Short communication.

International Nuclear Information System (INIS)

The distribution of i.v. administered lead ("2"0"3Pb-acetate; 50 nmol/kg b.w.) was studied by means of autoradiography and impulse counting in pregnant C57BL mice (day 18) treated orally with dithiocarbamates. Diethyldithiocarbamate (DEDTC), disulfuram or thiram (2 X 1) mmol/kg b.w.) or vehicle (gelatine) alone, was given by gavage 2 h before and immediately after the injection of lead. All three dithiocarbamates, especially thiram, changed the distribution pattern of lead. Thiram and DEDTC had the greatest effect at 4 h after lead administration, disulfiram at 24 h. In the mother, most notably the brain concentration increased (70-fold for thiram at 4 h) while that of erythrocytes and skeleton decreased (50- and 4-fold, respectively). The total fetal concentration unexpectedly showed only a moderate increase (proportional 2-fold for thiram), which may be due partly to the low maternal plasma lead concentration. The partition within the fetal ...

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Genomic instability can be produced by ionising radiation, so-called radiation-induced genomic instability, and chemical mutagens. Radiation-induced genomic instability occurs in both germinal and somatic cells and also in the offspring of irradiated individuals, and it is characterised by genetic changes including chromosomal rearrangements. The majority of studies of trans-generational, radiation-induced genomic instability have been described in the male germ line, whereas the authors who have chosen the female as a model are scarce. The aim of this work is to find out the radiation-induced effects in the foetal offspring of X-ray-treated female rats and, at the same time, the possible impact of this radiation-induced genomic instability on the action of a chemical mutagen. In order to achieve both goals, the quantity and quality of chromosomal damage were analysed. In order to detect trans-generational genomic instability, a total of 4806 ...

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The response of MOS capacitors to low- and medium-energy x-ray irradiation is investigated as a function of gate material (TaSi or Al), oxide thickness, and electric field. Measured device response is compared with predictions based on discrete ordinates and Monte Carlo code simulations of dose enhancement effects, coupled with recent estimates of electron-hole recombination in MOS oxides. In comparisons of 10-keV x-ray and Co-60 irradiations of Al-gate MOS capacitors at an oxide electric field of 1 MV/cm, it is found that predictions and experiments agree to within better than 20 percent for oxide thicknesses ranging from 35 to 1060 nm. For capacitors having TaSi/Al gates, predictions and experiments agree to within better than 30 percent at 1 MV/cm, with the largest differences occurring for 35-nm gate oxides. At other electric fields, the disagreement between experiment and prediction increases ...

International Nuclear Information System (INIS)

An x-ray fluorescence spectrometer was designed and fabricated which nondestructively determines the thickness of aluminum cladding at small suspected thin spots in the inner or outer surface of actinide reactor tubes. The analysis method is based on the difference in absorption of actinide L/sub #alpha#/ and L/sub #beta#/ fluorescent x-rays in passing through the cladding. Calibration plots of the logarithm of the L/sub #beta#//L/sub #alpha#/ x-ray intensity ratio versus cladding thickness are linear to at least 40 mils for U-Al, U_3O_8-Al, and PuO_2-Al substrates. Accuracy and precision of the experimentally determined cladding thickness and evaluated for both uranium and plutonium substrates. Experimental thickness data are reported for 618 quality assurance analyses on six Mark 41 PuO_2-Al target tubes. An x-ray fluorescence cladding thickness monitor operated with a computer-controlled fluoroscope ...

UK PubMed Central (United Kingdom)

Genetic studies of nicotine addiction in mice have utilized the oral self-administration model. However, it is unclear if strain differences in nicotine consumption are influenced by variation in bitter...Full Text Available

UK PubMed Central (United Kingdom)

We previously reported that global deletion of insulin receptor substrate protein 1 (Irs1) extends lifespan and increases resistance to several age-related pathologies in female mice....Full Text Available

UK PubMed Central (United Kingdom)

BackgroundGlucocorticoids down-regulate cytokine synthesis and suppress inflammatory responses. The glucocorticoid receptor (GR) antagonist RU486 may exacerbate the inflammatory...Full Text Available

UK PubMed Central (United Kingdom)

The in vivo antichlamydial activities of sparfloxacin and reference drugs were examined in a experimental model of pneumonia caused by Chlamydia pneumoniae in leukopenic mice; their in vitro activities...Full Text Available

UK PubMed Central (United Kingdom)

Experimental metastases in the brain of mice are infiltrated by microglia, and parabiosis experiments of green fluorescent protein (GFP⁺) and GFP^- mice revealed that these microglia...Full Text Available

UK PubMed Central (United Kingdom)

The influence of an immobilization stressor on lung cellular immune responses was studied. Delayed-type hypersensitivity to sheep erythrocytes was used to evaluate in vivo lung cellular immunity. Mice...Full Text Available

UK PubMed Central (United Kingdom)

In this study, our main objective was to determine whether energy restriction (ER) affects the rate of oxygen consumption of mice transiently or lastingly and whether metabolic rate plays a role in...Full Text Available

UK PubMed Central (United Kingdom)

An in vitro assay for curative antibody present in plasma of mice cured of Trypanosoma musculi is described. The assay involves the addition of plasma to a sample of infected blood, followed by hourly...Full Text Available

UK PubMed Central (United Kingdom)

Following the descovery of its transposition activity in mammalian culture systems, the Sleeping Beauty (SB) transposon has since been applied to achieve germline mutagenesis in mice....Full Text Available

UK PubMed Central (United Kingdom)

The hypothesis, that a decrease in metabolic rate mediates the life span prolonging effect of caloric restriction (CR), was tested using two strains of mice, one of which, C57BL/6, exhibits...Full Text Available

UK PubMed Central (United Kingdom)

We introduce cyclophosphamide-induced alopecia (CYP-IA) in C57BL-6 mice as a clinically relevant model for studying the biology of chemotherapy-induced alopecia and for developing anti-alopecia drugs....Full Text Available

UK PubMed Central (United Kingdom)

Mice homozygous for the recessive gene achondroplasia (cn) aged 16 and 17 days and some homozygotes aged 22-34 days have disruptions in the growth of the proximal tibial growth plate which are due solely...Full Text Available

International Nuclear Information System (INIS)

Free Electron Laser (FEL) with the wide wavelength tunability has been developed and used for various applications. The FEL gives high efficiency for the photo-induced ablation when the laser is tuned to an absorption maximum of the target. The FEL was tuned to 9.4 #mu#m, which is an absorption maximum of phosphoric acid ion, a known major component of dentine. The FEL pulse length was several ps. The average output power was varied from 5 to 20 mW by filters. The change of irradiated dentine surface was analyzed by mass spectroscopy and Energy Dispersive X-ray (EDX) spectroscopy. Positive ions which correspond to Na"+, CO_3"+ and many phosphoric acid ions were measured. It was found that atomic ratio of P/Ca had reduced from 0.65-0.60. The atomic ratio of P/Ca, however had not changed with irradiation by Er:YAG laser (2.9 #mu#m), or CO_2 laser (10.6 #mu#m). These results indicate the selective ablation of phosphoric acid ...

Energy Technology Data Exchange (ETDEWEB)

The detection efficiency of gamma scanning system in irradiated materials examination facility has been measured. Gamma-ray sources used in this experiment are Cs-Co standard sources a PWR spent fuel rod in which {sup 134}Cs and {sup 154}Eu peaks are clearly identified in the energy region of 500 to 1,600 keV. The distance between source and detector is about 1.6 m. A slit type collimator with 3 mm-width window and 30 mm-thick lead block are installed between source and detector. The detector is a HPGe detector. This equipment is mainly used in gamma scanning of irradiated nuclear fuel. The measured detection efficiency seems to be 1.89 x 10{sup -6} % for 1 MeV gamma-ray. With these results the activities of unknown sources could be measured. This results are expected to be used in the measurement of the absolute distribution of gamma emitting nuclides in nuclear fuel.

Energy Technology Data Exchange (ETDEWEB)

Graft copolymerization of sodium styrene sulfonate (SSS) onto electron beam (EB) irradiated poly(vinylidene fluoride) (PVDF) films was investigated to find out a simple preparation process for sulfonic acid proton exchange membranes with respect to monomer concentration, absorbed dose, temperature, film thickness and storage time. The reaction order of the monomer concentration and absorbed dose of grafting was found to be 2.84 and 1.20, respectively. The overall activation energy for graft copolymerization reaction was calculated to be 11.36 kJ/mol. The initial rate of grafting was found to decrease with an increase in the film thickness. The trapped radicals in the irradiated PVDF films remained effective in initiating the reaction without considerable loss in grafting level up to 180 days, when stored under -60 {sup o}C. The presence and distribution of polystyrene sulfonate grafts in the obtained membranes were observed by Fourier transform ...

Energy Technology Data Exchange (ETDEWEB)

Authors developed a C-arm type radiosurgery system of the linear accelerator suitable for stereotactic radiation therapy and a software for arranging 3-dimensional therapy in the system. In this system, the gantry far conical irradiation of 4 MV (0.6-3 Gy/min) and 6 MV (0.9-4.5 Gy/min) X ray or electron beam for the therapy was connected to a newly designed C-arm and was made capable of rotating around either of the axes crossing vertically. With this system, it became unnecessary to move the bed table of the patient for getting suitable distribution of radiation dose. The local accuracy which was measured by the CCD videocamera on the gantry, was within 0.5 mm from the radiation center. The system made it possible to shorten the irradiation time and to improve the local accuracy of irradiating site. The clinical trial was begun from June, 1996. (K.H.)

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PMID:20856939

UK PubMed Central (United Kingdom)

The sera of NZB/BL mice have been found to be active in the complement fixation test against isogeneic liver antigens to a higher titre than the sera of CBA, C57BL and DBA/2 mice. Six sera from NZB...Full Text Available

Science.gov (United States)

The experiment was designed to study the effects of sodium pentobarbital on behavioral thermoregulation in rats and mice. Male Sprague-Dawley rats were given intraperitoneal (i.p.) injections of sodium pentobarbital in doses of 0, 1, 5, 10 or 15 mg/kg and male CBA/J mice were giv...

Energy Technology Data Exchange (ETDEWEB)

Using conventional deep level transient spectroscopy (DLTS), we have characterized the defects introduced in OMVPE n-GaAs at 15 K by 5.4 MeV alpha particle irradiation from an americium 241 radio-nuclide. After this low temperature irradiation two new defects not yet reported for alpha irradiated GaAs before, E[alpha]7 and E[alpha]9, were detected 0.07 eV and 0.19 eV below the conduction band, respectively. The introduction rates of E[alpha]7 and E[alpha]9 are calculated to be 41 cm[sup -1] and 187 cm[sup -1] respectively. It was observed that both defects obeyed first order annealing kinetics, with E[alpha]9 being removed at 225 K and E[alpha]7 at 245 K corresponding to the well known stage I annealing region. The annealing rate of E[alpha]7 corresponds to an activation energy of 0.86 eV, with a pre-exponential factor of 1.0 x 10[sup 15]s[sup -1]; and the removal of E[alpha]9 has an activation energy ...

International Nuclear Information System (INIS)

The authors present the results of an investigation of the effect of gamma radiation on the properties of low-molecular moulded polymethyl methacrylates (molecular weight distribution, physico-mechanical properties, resistance to the effects of aqueous media and physiological solution) in the form of copolymers of methyl methacrylate with methyl acrylate (MA) or butyl acrylate (BA) with the brand names Dacryl-4B, Dacryl-2M and Dacryl-4M (4% BA; 2 and 4% MA respectively) having a molecular weight of around 10"5. For comparison, block polymethyl methacrylate with a molecular weight of 3 x 10"6 was used. The results of experiments on the ageing of unirradiated and irradiated specimens in a heated store-room (t = 10 - 20"0C) and at high temperatures (90"0C) are also given. It is shown that irradiation with doses of 2.5 - 20 Mrad leads to radiolysis of the above copolymers, accompanied by destructive processes. Evidence of this ...

Energy Technology Data Exchange (ETDEWEB)

The nine papers presented at this conference cover the following topics: the systematization, condensed description, and prediction of sets of anion exchange extraction constants on the basis of their statistical computer treatment; characteristics and uses of solid extractants containing D2EHPA and TBP for separating the transplutonium elements; enrichment of americium 242m and americium 242 by the Szilard-Chalmers method; an x-ray diffraction pattern analysis for transplutonium compounds; the radiation chemistry of americium; and the effects of alpha irradiation on the behavior of americium in perchlorate solutions.

International Nuclear Information System (INIS)

A mixture of aminoacids was irradiated by a scattered proton beam, its energy varying from 4 to 6.6 MeV, by doses up to 5 x 10"1"1 proton/cm"2 for studying the potentiality of abiogenic synthesis of biologically important compounds in space. It was ascertained that increase in the radiation dose and reduction of proton energy involve increase in effectiveness both of destruction of the initial aminoacid (tryptophan, tyrosine, glycine) and synthesis of the relevant dipeptide. Essential influence of mineral substrate on abiogenic synthesis of natural nucleotides under the action of diverse energy sources was pointed out

International Nuclear Information System (INIS)

The mono- and intramolecular cation-radicals (CR) reactions of diethylmercury in the CFCl_3, CFCl_2CF_2Cl matrices and CF_2BrCF_2Br and CFCl_3 freons vitrified mixture (1:1) were studied through the EPR method. Formation of radical products of transformations of the initial CR diethylmercury (X-ray radiation dose - 100-200 Gy at the temperature of 293 K) was studied through the spin trap of 2.4.6 - tri-tret-butylnitrosebenzene.

Energy Technology Data Exchange (ETDEWEB)

X-ray irradiation-induced paramagnetic radicals in rare earth (Ln) ion-doped glaserite and Ln ion-doped langbeinite were studied by means of ESR technique, aiming at developing the highly sensitive sensor for an ESR dosimetry. The samples were prepared by two kinds of procedures as follows. In one process, the glaserite (K{sub 3}Na(SO{sub 4}){sub 2}) matrix or the langbeinite (K{sub 2}Mg{sub 2}(SO{sub 4}){sub 3}) matrix were synthesized by heating the mixture of K{sub 2}SO{sub 4} and Na{sub 2}SO{sub 4} or the mixture of K{sub 2}SO{sub 4} and MgSO{sub 4} at 1023 K for 1 hour in He flow. The matrices obtained were mixed well with a fixed amount of Ln{sub 2}(SO{sub 4}){sub 3} (Ln=La, Eu, Gd, Lu) powder and heated at 1023 K for 1 hour in He flow. In the other process, the homogeneous mixture of a fixed amount of K{sub 2}SO{sub 4}, Na{sub 2}SO{sub 4} and Ln{sub 2}(SO{sub 4}){sub 3} powders or a fixed amount of K{sub 2}SO{sub 4}, MgSO{sub 4} and ...

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Excessive irradiation due to unexpected leakage was found on a patient receiving electron beam therapy. The cause of this leakage was analyzed and the amount of leakage was measured for different electron beam energies. The highest leakage occurred with a 6 x 6 cm cone using a 12 MeV electron beam. The leakage dose measured along the side of the cone could be as great as 40%. Until the cones are modified or redesigned, it is advised that all patient setups be carefully reviewed to assure that no significant patient areas are in the side scatter region.

British Library Electronic Table of Contents (United Kingdom)

Manganese toxicity can cause a neurodegenerative disorder affecting cortical and basal ganglia structures with a neurological presentation resembling features of Parkinson's disease. Children are more sensitive to Mn-induced neurological dysfunction than adults, and recent studies from our laboratory revealed a marked sensitivity of male juvenile mice to neuroinflammatory injury from Mn, relative to females. To determine the role of estrogen (E2) in mediating sex-dependent vulnerability to Mn-induced neurotoxicity, we exposed transgenic mice expressing an NF-kB-driven enhanced green fluorescent protein (EGFP) reporter construct (NF-kB-EGFP mice) to Mn, postulating that supplementing male mice with E2 during juvenile development would attenuate neuroinflammatory changes associated with glia...

International Nuclear Information System (INIS)

The state of prooxidant-antioxidant homeostasis in Guinea pigs exposed to whole-body fractionated X-irradiation (5 fractions of 0.2 Gy at a 24 hr interval, up to total dose of 1.0 Gy, at a dose rate of 0.425 R/min) and a possibility of its disturbance correction with the complex of vitamins C, E and P was studied. Accumulation of primary and secondary lipid peroxidation products, decrease of the ascorbic acid content, increase of the content of its oxidized forms (dehydroascorbic acid and diketogulonic acid) in radiosensitive and radioresistant organs were found. Antioxidant complex administration reduced the disturbances of prooxidant-antioxidant homeostasis, but did not provide complete normalization.

International Nuclear Information System (INIS)

The scope of radioanalysis can be enlarged substantially by preconcentration. The minimal concentration factor required depends on the concentration to be determined, the limit of determination of the analytical technique and the maximal acceptable sample-weight. Simultaneously, the preconcentration step may cause a decontamination. In post-irradiation chemistry this is usually the crucial parameter. The present paper proposes the classification of (pre-) concentration techniques by the relation between the concentration-factor X and the decontamination-factor Y. In addition, three other criteria here are used to judge the applicability in combination with the analytical technique chosen. They stem from the minimal representative and the maximal acceptable sample-weights and the maximal acceptable dose-rate. The features of a particular combination of (pre-) concentration and analytical technique can be visualized in an X-Y ...

International Nuclear Information System (INIS)

When evaluating the risks of oncogenesis and cancer mortality following exposure to the radiations of the atomic bombs (A-bombs), the medical X-ray doses received by the A-bomb survivors must also be estimated and considered. Using a human phantom, dosimetry was performed to estimate the X-ray doses received by A-bomb survivors during medical examinations at the Radiation Effects Foundation (RERF) as part of the long-term follow-up on the Adult Health Study (AHS). These examinations have been estimated to represent nearly 45% of the survivors' cumulative medical irradiation dose. Doses to the salivary glands, thyroid gland, lung, breast, stomach and colon were measured using thermoluminescent dosemeters. The results, which are reported here, will aid in estimating organ doses received by individual AHS participants. (Author).

Energy Technology Data Exchange (ETDEWEB)

Evaporated palladium films of 45 nm thickness on Si(111) were irradiated using 78 keV Ar/sup +/ ions with doses in the range of 1 x 10/sup 15/ to 1.5 x 10/sup 16/ cm/sup -2/ for the purpose of studying silicide formation. Rutherford backscattering analysis shows that intermixing has occurred across the Pd-Si interface at room temperature. The mixing behaviour increases with increasing dose of the bombarding ions, which agrees well with a theoretical model of isotropic cascade mixing for palladium, and radiation-enhanced diffusion associated with an interstitial mechanism for silicon.

Science.gov (United States)

The low in vivo transduction efficiency of recombinant adeno-associated virus (rAAV) and the undesirably strong immunogenicity of adenovirus (rAdv) have limited their clinical utilization in cancer gene therapy. We have previously demonstrated that intratumoral injection of rAAV expressing a C-terminal polypeptide of human telomerase reverse transcriptase (rAAV-hTERTC27) effectively inhibits the growth of glioblastoma xenografts in nude mice. To further improve its efficacy, we combined rAAV-hTERTC27 with rAdv and investigated the efficiency of the cocktail vectors in vivo. At a nontherapeutic dose (1 x 10(8) plaque-forming units (PFUs)), rAdv-null and rAdv-hTERTC27 were equipotent in enhancing the therapeutic efficacy of rAAV-hTERTC27 (1.5 x 10(11) v.g.), and complete tumor regression was achieved in 25% of the treated animals. Importantly, the combination of rAAV-hTERTC27 and a therapeutic dose (2.5 x ...

International Nuclear Information System (INIS)

Pregnant Swiss albino mice of 18 days post conception were exposed to 0.80 Gy, 0.40 Gy and 0.20 Gy of gamma rays from a Cobalt-60 source at different dose rates (.0584 Gy/min and .00091 Gy/min). Post irradiation variations in the cell population of crypts and villus of jejunum were studied in the F_1-generation at 1 day, 3 day and 1,2,4,6 and 12 weeks of post-partum age. In all the exposure groups at 1 day post-partum age, crypts show a decrease in total cells, mitotic figures and goblet cells on one hand and an increase in PNNC on the other hand in comparison to coeval controls. At this interval a decrease in the number of total cells as well as goblet cells/villus column was also noticeable. Dead cells which were prominently seen in crypts were totally absent in villi. The first signs of recovery can be observed on day 3 p.p. when total cell population, mitotic activity and goblet cells of crypt registered an increase while percentage of PNNC ...

International Nuclear Information System (INIS)

As a series of estimations of population doses and of risk estimates from medical exposures in Japan, the malignancy significant dose (MSD) and the fatal malignant risk from beam therapy were estimated based on a nationwide survey of radiotherapeutic treatments, using a malignancy significant factor and a weighting factor determined from the data on the cancer mortality among the atomic bomb survivors in Nagasaki. The effective dose was defined as a sum of the product of the weighting factor and the organ or tissue doses with respect to the malignant diseases. The organ or tissue doses were determined with ionization chambers placed at the positions of their center in a MixDp-phantom simulated lung tissues by a block of cork, using a telecobalt unit, a conventional X-ray unit and a medical linear accelerator. The organ or tissue doses were categorized into three dose components; namely 1) dose from useful beams; 2) scattered radiation dose from ...

International Nuclear Information System (INIS)

Polymer sealing parts are widely used in various branches of engineering as detachable joints that operate at normal and cryogenic temperatures. They are also used in nuclear-power engineering to seal pumps, pipelines, etc., where they operate at 600-650 K under a neutron fluence of around 10"1"6 cm"-"2 (E #>=# 0.18 MeV) and concomitant #gamma#-irradiation of about 10"6 R. The fluoroplastic-based materials currently used degrade when irradiated in water at 320-360 K with a neutron fluence of 10"1"5 cm"-"2 (thermal neutrons) or 10"1"4 cm"-"2 (fast neutrons), and a concomitant #gamma#-irradiation dose of 2 x 10"6 R. The strength of these fluoroplastics decreases markedly after #gamma#-irradiation (from a cobalt source) at room temperature at doses above 10"6 R. For this reason, flexible and swelling graphites are finding ever increasing application. Graflex foils made of extra-pure ...

International Nuclear Information System (INIS)

Radiation hardening and radiation-induced chromium (Cr) depletion were related to intergranular stress corrosion cracking (IGSCC) response among various stainless steels (SS). Available data on neutron-irradiated materials were analyzed and correlations developed between fluence, yield strength, grain-boundary Cr concentration, and cracking susceptibility in high-temperature water environments. Large heat-to-heat differences in the critical fluence (0.2 neutrons/cm"2 to 2.5 x 10"2"1 neutrons/cm"2) for IGSCC were documented. Variability often was consistent with yield strength differences among irradiated materials. IGSCC correlated better to yield strength than to fluence for most heats, suggesting a possible role for radiation-induced hardening (and microstructure) on cracking. However, isolated heats revealed a wide range of yield strengths (450 MPa to 800 MPa) necessary to promote IGSCC which could not be explained by ...

Energy Technology Data Exchange (ETDEWEB)

Diel vertial migrations of the marine dinoflagellates Gonyaulax polyedra Stein and Ceratium furca (Ehr.) Clap. et Lachm, were followed in a laboratory tube (2.02 m x 0.25 m) under a 12:12h light:dark cycle. The effects of temperature stratification, two levels of surface irradiance and nitrogen depletion on patterns of vertical migrations were examined. At temperatures between 22 to 26/sup 0/C with small temperature gradients, both species migrated at a rate of 0.7 to 1.0 mh/sup -1/. Steeper thermoclines (ca. 0.8/sup 0/C 0.1 m/sup -1/) with temperatures below ca. 20/sup 0/C caused a marked decrease in swimming speed which resulted in accumulations of cells in these thermocline regions. Under conditions of nutrient sufficiency both algae migrated into the surface layers at irradiance values of over 1000 ..mu..E m/sup -2/s/sup -1/. Increasing nitrogen depletion caused the downward migration of both algae to commence ...

International Nuclear Information System (INIS)

The authors present the results of an investigation of the effect of gamma radiation on the properties of low-molecular moulded polymethyl methacrylates (molecular weight distribution, physicomechanical properties, resistance to the effects of aqueous media and physiological solution) in the form of copolymers of methyl methacrylate with methyl (MA) or butyl acrylate (BA) with the brand names Dacryl-4B, Dacryl-2M and Dacryl-4M (4% BA; 2 and 4% MA respectively) having a molecular weight of around 10"5. For comparison, block polymethyl methacrylate with a molecular weight of 3 x 10"6 was used. The results of experiments on the ageing of unirradiated and irradiated specimens in a heated store-room (t = 10 - 20"0C) and at high temperatures (90"0C) are also given. It is shown that irradiation with doses of 2.5-20 Mrad leads to radiolysis of the above copolymers, accompanied by destructive processes. Evidence of this is an ...

Energy Technology Data Exchange (ETDEWEB)

Purpose: Antitumor activity of the dichloroplatinum(II)-histamine complexes labeled with I-125 or I-131 was investigated in a transplantable murine adenocarcinoma (MA) model. Methods: The tumor model was obtained in C3H/W female mice after subcutaneous inoculation of the tumor cells derived from the mice bearing a mammary tumor of spontaneous origin. Antitumor activities of the platinum-histamine complexes were investigated in three independent experiments, which differed in applied doses of preparations (PtCl{sub 2}Hist, PtCl{sub 2}[{sup 125}I]Hist, PtCl{sub 2}[{sup 131}I]Hist, PtCl{sub 2}Hist/PtCl{sub 2}[{sup 125}I]Hist and PtCl{sub 2}Hist/PtCl{sub 2}[{sup 131}I]Hist), treatment schedules as well as stages of the disease progress in the animals used. Experiment 1 included long-term, multidose treatment with low single doses (treatment duration 31-32 days; 8-10 doses of ca. 0.25{center_dot}MTD{sub Pt} each). Experiment 2 included short-term, ...

International Nuclear Information System (INIS)

This work describes an experimental verification of the two-photon dose calculation engines available on the Helax-TMS (version 6.1) commercial radiotherapy treatment planning system. The performance of the pencil beam convolution and the collapsed cone superposition algorithms was examined for 4, 6, 15 MV beams, under a range of clinically relevant irradiation geometries. Comparisons against measurements were carried out in terms of absolute dose, thus assessment of the accuracy of monitor unit (MU) calculations was also carried out. Results show that both algorithms agree with measurement to acceptable tolerance levels in most cases in homogeneous water-equivalent media irradiated under full scatter conditions. The collapsed cone algorithm slightly overestimates the penumbra width and this is mainly due to discretization effects of the fluence matrix. The accuracy of this algorithm strongly depends on the resolution of the patient density ...

Energy Technology Data Exchange (ETDEWEB)

Full text: In 1995, we demonstrated the use of pretargetting three steps method and biotinylated tetracycline using radiolabelled {sup 99m}Tc-DTPA-biocytinamide for the detection of tumour cells in (C57B1/6 x BALB/C) F1 mice with E-3 thymoma. The three steps were (1) IP injection of biotinylated-tetracycline conjugate (1:1) ratio, (2) 96 hours later Avidin/Streptavidin was injected, and (3) 24 hours after (2), {sup 99m}Tc-biocytinamide -cDTPA was injected. Mice were sacrificed 16/24 h after (3) by cervical dislocation. Biodistribution of radioactivity tumour to blood, liver, bone were T:B1= 15.0, T:Li= 5.08, T:Bo=15.0. The percentage of injected dose per g was T= 3.15% and B1= 0.21%. To prolong circulation of Avidin and therefore its uptake into tumour, Avidin was covalently bound to polyethylene-glycol (PEG20 KD) at the molar ratio of PEG:Avidin 100:1 and 400:1. The pegulated Avidin was then cleared from the circulation ...

British Library Electronic Table of Contents (United Kingdom)

Si nanocrystal floating gate MOS capacitors were formed on p-Si (100) wafers by thermal plasma jet (TPJ) annealing of SiO2/SiOx /SiO2/Si(100) stacked structure. The chemical composition of SiOx layer was controlled by changing the SiH4, He, and O2 gas flow ratio during plasma enhanced chemical vapour deposition. The MOS capacitors showed clear hysteresis in capacitance-voltage (CV) characteristics after TPJ annealing. The hysteresis width shows maximum value when initial composition x =1.7, which shows the maximum photoluminescence (PL) intensity. The maximum hysteresis width of 6.8 V was observed with gate voltage swept between 20 and -20 V in x = 1.7 sample. The result means 7.4 x 1012 cm-2 carriers are injected to or emitted from Si nanocrystals. The duration of 1 V shift in flatband vo...

International Nuclear Information System (INIS)

This study was undertaken to investigate the effects of neonatal asphyxia on brain development, with special reference to the kinetics of neuronal proliferation by using autoradiography. For 30 minutes, two-day-old suckling mice, Jcl:ICR strain, were put into a chamber which was constantly flushed with 100% CO_2 gas. After the exposure to asphyxia, 29% of the mice survived. Cell cycle studies were carried out at two days and at seven days on the external matrix cells, the precursor of the granule cells, at the external granular layer of the cerebellum from CO_2-exposed and control mice by "3H-thymidine autoradiography. At two days the generation time of the control mice was about 15 hours, whereas that of the asphyxiated mice was about 17 hours. The prolongation of the generation time in the asphyxiated mice was caused mainly by a delay in the G2 phase. This ...

International Nuclear Information System (INIS)

Type 304 stainless steels (solution annealed material, cold worked material and fine grain material) were neutron irradiated to 3 x 10"2"5n/m"2 at 290degC and at 50degC. Each specimen was examined by SSRT test in high temperature water with 8 ppm dissolved oxygen and Ar gas environments. Results were as follows: (1) IASCC susceptibility of each material can be classified by 0.2% proof stress (PS) obtained from SSRT test in Ar gas: No IASCC susceptibility was observed in the PS range 850 MPa. (2) The uniform elongation (UE) in Ar gas environment decreased with increasing PS up to 800 MPa, and became about 0% in the PS range >800 MPa. (3) It was suggested that IASCC did not occur even if material had IASCC susceptibility, when under a condition that brittle fracture mechanism controls a specimen failure. (author)

International Nuclear Information System (INIS)

A technique of producing radioactive isotopes of rare earth elements (r.e.e.) and carrier free "2"4"2Am is suggested. The technique makes use of ''sandwich'' phthalocya=- nine complexes of r.e.e. and americium placed on sorbent. This is a new type of r.e.e. compounds and actinides (C_3_2H_1_6N_8)_2M (M is a metal ion) which are thermally, radiationally and chemically stable, dissolve well in some organic solvents and do not dissolve in water. Radiation and chemically stable activated carbon is used as a sorbent carrier. After irradiation the target is treated by a weakly acid solution or complex-former solution. Radioactive atoms formed due to (n, #gamma#)-reaction and desoleting the complex because of recoil transfer into the solution. When irradiating in the flux of 10"1"3 neutr./cm"2 x s for 1 hour it is possible to produce radioactive isotopes with the yield from 20 to 90%, for example "1"6"0Tb, "1"6"6Ho with enrichment ...

International Nuclear Information System (INIS)

A combination of measuring instruments, consisting of a Beta-Sedimeter and a radionuclide X-ray fluorescence instrument, is described. With the Beta-Sedimeter the C-14-radiation is measured. Through direct irradiation with photons of a Pu238-source in an ancillary irradiation chamber and energy dispersing measurement of the K- and L-radiation resp. of the excited heavy metals with the aid of a Si(Li)-semiconductor detector and a 4-channel analyzer the heavy metal concentrations of the heavy metals Zn, Cr, Ni and Pb are determined. For the determination of cadmium the indirect excitation with Am-241 and Dy-targets is described. The system produces records and operates fully automatically in a step-by-step mode with a testing cycle of 45 minutes. In connection with the process monitoring of the wastewater from a zinc plating plant during a period of 8 months the concentration of the solid material and of the metals Cr and Zn, ...

International Nuclear Information System (INIS)

A series of experimental measurements of the yield of O_3 in nuclear-induced O_2 and O_2-SF_6 discharges are reported. The discharges were created by bombardment with energetic particles from the "1"0B(n,#alpha#)"7Li reaction. Continuous irradiation at dose rates of 10"1"5--10"1"7 eV cm"-"3 s"-"1 and pulsed irradiation (--10 ms FWHM) at a peak dose rate of --10"2"0 eV cm"-"3 s"-"1 were conducted. At the lower dose rates, the addition of SF_6 generally increased the ozone yield due to the slowing of ozone destruction by negative oxygen and ozone ions. In contrast, at the high dose rates, the ozone concentration decreased due to SF_6 suppression of atomic oxygen formation by ion--ion recombination. A numerical model was developed and tested against experimental conditions. This model indicates that the steady-state ozone concentration was limited by the reaction O"-_3+O_3#->#2O_2+O"-_2 with a rate coefficient of --1 x ...

KoreaScience (Korea)

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KoreaScience (Korea)

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Energy Technology Data Exchange (ETDEWEB)

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Science.gov (United States)

... these estimates were obtained from these and the parameter covariance matrix using a parametric bootstrap method. We present the ... ...

British Library Electronic Table of Contents (United Kingdom)

Nano-sized silica is a promising material for disease diagnosis, cosmetics and drugs. For the successful application of nano-sized material in bioscience, evaluation of nano-sized material toxicity is important. We previously found that nano-sized silica particles with a diameter of 70nm showed acute liver failure in mice. Here, we performed histological analysis of major organs such as the liver, spleen, lung, kidney, brain and heart in mice, chronically injected with 70-nm silica particles for 4weeks. Histological analysis revealed hepatic microgranulation and splenic megakaryocyte accumulation in these 70-nm silica particles treated mice, while the kidney, lung, brain and heart remained unaffected. Thus, liver and spleen appear to be the major target organs for toxicity by the chronic a...

UK PubMed Central (United Kingdom)

BackgroundCystinuria is the most common inherited cause of urinary tract stones in children. It can lead to obstructive uropathy, which is a major cause of renal...Full Text Available

International Science & Technology Center (ISTC)

Fundamental Research of Materials Structure and Properties Changes Resulted from Irradiation by Means of Complex of Modern Physical Methods

Energy Technology Data Exchange (ETDEWEB)

Si nanocrystal floating gate MOS capacitors were formed on p-Si (100) wafers by thermal plasma jet (TPJ) annealing of SiO{sub 2}/SiO{sub x} /SiO{sub 2}/Si(100) stacked structure. The chemical composition of SiO{sub x} layer was controlled by changing the SiH{sub 4}, He, and O{sub 2} gas flow ratio during plasma enhanced chemical vapour deposition. The MOS capacitors showed clear hysteresis in capacitance-voltage (CV) characteristics after TPJ annealing. The hysteresis width shows maximum value when initial composition x =1.7, which shows the maximum photoluminescence (PL) intensity. The maximum hysteresis width of 6.8 V was observed with gate voltage swept between 20 and -20 V in x = 1.7 sample. The result means 7.4 x 10{sup 12} cm{sup -2} carriers are injected to or emitted from Si nanocrystals. The duration of 1 V shift in flatband voltage was {proportional_to}0.1 ms with 20 V ...

International Nuclear Information System (INIS)

A series of separation experiment was performed in order to study a multi-functional spent fuel reprocessing process based on ion-exchange technique. The tertiary pyridine-type anion-exchange resin was used in this experiment and the mixed oxide fuel highly irradiated in the experimental fast reactor ''JOYO'' was used as a reference spent fuel. As the result, "1"0"6Ru + "1"2"5Sb, "1"3"7Cs + "1"5"5Eu + "1"4"4Ce, plutonium, americium and curium could be separated from the irradiated fuel by only three steps of ion-exchange. The decontamination factor of "1"3"7Cs and trivalent lanthanides ("1"5"5Eu, "1"4"4Ce) in the final americium product exceeded 3.9 x 10"4 and 1.0 x 10"5, respectively. The decontamination factor for the mutual separation of "2"4"3Cm and "2"4"1Am was larger than 2.2 x 10"3 for the americium product and, moreover, the content of "1"3"7Cs, trivalent lanthanides and ...

Energy Technology Data Exchange (ETDEWEB)

The aim of this study was to investigate whether sub-ablative pulsed C0{sub 2} laser (1 0,6 {mu}m) irradiation is capable of reducing the susceptibility of the dental enamel to demineralization, and thus achieving a potential caries-protective effect. The crowns of 51 bovine front teeth, embedded in acrylic resin and polished until exposure of flat enamel surface, were used. The samples were cut in cubes of 10x10 mm, and totally coated with acid-resistant nail varnish, except for an enamel exposed window of 16 mm square. Three groups (n=17) were obtained: control group (CG) not irradiated; group laser A (LA) and group laser B (LB) where the samples were irradiated. The conditions were 60 mJ, 100 Hz, 0,3 J/cm{sup 2} for LA and 135 mJ, 10 Hz, 0,7 J/cm{sup 2} for LB. Two samples of each group were submitted to SEM analysis and fifteen to demineralization in 3 ml acetate buffer solution (0,1 mol/L) with pH ...

International Nuclear Information System (INIS)

This paper presents results of studying the thermo-transferred thermoluminescence (TTTl) phenomenon in potassium-yttrium double fluoride doped with terbium (K_2YF_5_:Tb) at different impurity concentrations (0.8%, 0.95% and 0.99%). Previously to study the TTTl phenomenon, structural characterization and chemical composition of the materials were determined. The structural studies were conducted using a scanning electron microscope; meanwhile, chemical composition was analyzed using energy dispersive X-ray spectroscopy. Thermoluminescence kinetics was studied irradiating the samples with "1"3"7Cs gamma rays as well as with "9"0Sr/"9"0Y beta rays, analyzing the glow curves by the deconvolution method for obtaining the kinetic parameters. (Author)

International Nuclear Information System (INIS)

High-flux neutron sources are continuing to be of interest both in Canada and internationally to support materials testing for advanced power reactors, new developments in extracted-neutron-beam applications, and commercial production of selected radioisotopes. The advanced MAPLE reactor concept has been developed to meet these needs. The advanced MAPLE reactor is a new tank-type D_2O reactor that uses rodded low-enrichment uranium fuel in a compact annular core to generate peak thermal-neutron fluxes of 1 x 10"1"9 n#centre dot#s"-"1 in a central irradiation rig with a thermal power output of 50 MW. Capital and incremental development costs are minimized by using MAPLE reactor technology to the greatest extent practicable.

International Nuclear Information System (INIS)

Radiosensitization by lactate, pyruvate, nalidixic acid and novobiocin was studied in exponentially growing SH-18L human lung fibroblasts. All the chemicals had a slight radiosensitizing effect at a low concentration and a definite effect at a higher one. Decreases in the D_0 and/or Dq values were present in each dose survival curve. Fibroblasts incubated with the low concentration of each chemical for 24 hrs after X irradiation showed no reduction in intracellular ATP content, whereas, the higher concentration produced a significant decrease. These observations suggest that the decrease in the ATP content may be involved in the radiosensitization of human fibroblasts at high concentrations of these chemicals. In contrast, radiosensitization at a low concentration is not explained by a relationship to ATP content. Different mechanisms may be involved in radiosensitization at low and high concentrations of these chemicals. (author).

International Nuclear Information System (INIS)

The effect of high energy neutron (E greater than 1 MeV) irradiation at 60"0C on the superconducting critical temperature, T/sub c/, the upper critical field, H/sub c2/, the lattice parameter, a_0, and the degree of Long Range Order has been measured for Nb and V based A-15 superconducting compounds. Large reductions in T/sub c/"0 and H/sub c2/ are observed for fluences up to 5.0 x 10"1"9 n/cm"2. For Nb_3Al, a_0 increases and the degree of Long Range Order is significantly reduced as T/sub c/ is depressed. Results are discussed in terms of atomic ordering in the A-15 structure.

Energy Technology Data Exchange (ETDEWEB)

With the exception of the 1945 Hiroshima and Nagasaki nuclear weapon explosions and the 1986 Tchernobyl reactor accident, most of the radiation accidents concerns the medical and the traditional industrial sectors. The seriousness of the accident is directly function of the absorbed dose. The paper, first, gives the definition of a radiologic accident with its specific criteria and pathological manifestations. Then, some famous historical accidents are reviewed from the discovery of X-rays to recent acute irradiations due to the careless manipulation of radiation sources. From this analysis, three main causes are put forward: the dysfunction of nuclear medicine apparatuses, the victims` lack of training and knowledge of the risks, and the non-identification or the loss of radiation sources. (J.S.). 1 photo.

Science.gov (United States)

STRESS. VIBRATION DISTRIBUTION FATIGUE FOD. BLADE. X. X. X. X. HUB. X. X. X. SPINNER. X. X. X. Figure 21. - Large scale component test matrix. ...

UK PubMed Central (United Kingdom)

C57BL/6ByJ (B6) and 129P3/J (129) mice have different alleles of Tas1r3, which is thought to influence gustatory transduction of sweeteners, but studies have provided conflicting...Full Text Available

Science.gov (United States)

The properties of a nonviable, aqueous ether-extracted Brucela abortus preparation, Bru-Pel, are described. In addition to inducing a "virus-type" interferon response and protecting mice against challenge with otherwise lethal doses of Semliki Forest virus, Bru-Pel is demonstrated to have potent antitumor properties in mice. These antitumor effects appear to be mediated by an increase in nonspecific resistance similar to that seen with other experimental antitumor agents. PMID:728911

UK PubMed Central (United Kingdom)

We have recently shown that viable Borrelia burgdorferi organisms induce a chronic infection associated with arthritis and carditis in severe combined immunodeficiency (scid) mice but not in immunocompetent...Full Text Available

UK PubMed Central (United Kingdom)

Subchronic exposure to pharmacological levels of estrogenic compounds, including 17 beta-estradiol, diethylstilbestrol, and alpha-dienestrol, significantly increased the mortality of B6C3F1 female mice...Full Text Available

UK PubMed Central (United Kingdom)

Following infection with the protozoan parasite Leishmania major, C57BL/6 mice develop a small lesion that heals spontaneously. Resistance to infection is associated with the development...Full Text Available

International Nuclear Information System (INIS)

A post-irradiation annealing study was conducted with use of reactor pressure vessel(RPV) steel A533B C1.1 base metal irradiated to a dose of 4.84x10"1"8 n/cm"2 at about 380 deg C. Microhardness and positron annihilation (PA) methods were used to obtain better understanding of the recovery of radiation hardening. Isochronal anneal experiments indicated that two recovery processes occur during annealing of irradiated specimens. The first recovery process occurs in the temperature of 280-305 deg C. The variations of Ip, Iw and R parameters indicated that the formation of vacancy clusters by vacancy aggromeration and the annihilation parameters measured indicated that the dissolution of carbon atoms decorated around vacancy-type defects and possible precipitates, and the annihilation of monovacancies give rise to the second recovery process. It was further indicated that radiation anneal hardening (RAH) in ...

International Nuclear Information System (INIS)

Focused Ion Beam (FIB) milling is a powerful tool to produce ordered magnetic nanostructures. However, it is impossible to produce out-of-plane magnetized nanoscale structures from multilayer films by direct FIB writing. Co/Pt multilayers exhibit an out-of-plane easy axis due to strong perpendicular interface anisotropy. The interface contribution is known to be very sensitive to high energy ion irradiation. In case of 30 keV Ga ions it needs less than one ion per 100 surface atoms to destroy the perpendicular interface anisotropy. We demonstrate how this problem can be overcome by milling a Co/Pt multilayer, which has been deposited on a SiN membrane, from the rear side, through the SiN. The effect of the ions is determined as a function of applied dose utilizing the domain structure imaged by soft X-ray holography. When the magnetic material is removed we find only a very narrow range of destruction around the holes in contrast to the ...

Energy Technology Data Exchange (ETDEWEB)

A thermoluminescence (TL) sheet and its spatial readout system for in vivo measurement of spatial dose distribution around sources has been newly developed for intracavitary high dose-rate radiation therapy. The TL sheet (40 cm x 50 cm x 200 {mu}m), which is composed of teflon mixed with BaSO{sub 4} (Eu doped) powder, has a linear response with a very wide dynamic range from at least 0.002 cGy to 5000 cGy for {sup 60}Co sources. Phantom test of the TL sheet readout system demonstrated that absorbed dose with TL sheet and that with ionization chamber as standard dosimeter agreed well. For clinical application, TL sheet was attached on an applicator of intracavitary radiation therapy for rectal cancer. After irradiation with high dose-rate {sup 60}Co sources, the in vivo dose distribution on the surface of the rectum was determined. The TL sheet was suggested to provide a convenient means of measuring the dose distribution ...