WorldWideScience
1

Extracellular Protein Disulfide Isomerase Regulates Feedback Activation of Platelet Thrombin Generation Via Modulation of Coagulation Factor Binding.  

Science.gov (United States)

Background: Protein disulfide isomerase (PDI) controls platelet integrin function, tissue-factor (TF) activation, and concentrates at fibrin and thrombus formation sites of vascular injury. Objective: We investigated involvement of surface thiol isomerases and especially PDI, in thrombin-mediated thrombin amplification on human platelets. Methods/Results: Using a new developed thrombin-dependent platelet thrombin generation assay we observed that the feedback activation of thrombin generation on the platelet surface does not depend on TF, as anti-TF antibodies inhibiting TF-induced thrombin formation in platelet-depleted plasma had no effect compared to vehicle-treated controls. Feedback activation of thrombin generation in the presence of platelets was significantly diminished by membrane impermeant thiol blockers or by the thiol ...

2011-09-19

2

Interaction of Platelet Membrane Receptors with von Willebrand Factor, Ristocetin, and the Fc Region of Immunoglobulin G  

UK PubMed Central (United Kingdom)

The agglutination of human platelets by ristocetin and von Willebrand factor was inhibited by aggregated immunoglobulin (Ig)G and by Fc fragments of IgG, but not by Fab, F(ab′)2 or...Full Text Available

1978-11-01

3

Active release of human platelet factor VIII-related antigen by adenosine diphosphate, collagen, and thrombin.  

UK PubMed Central (United Kingdom)

Platelet Factor VIII-related antigen (VIIIR:Ag) represents a significant proportion of the total circulating VIIIR:Ag pool. However, its participation in the events of primary hemostasis has not been...Full Text Available

1978-12-01

4

Platelet fibrinogen binding in Basset Hound Hereditary Thrombopathy  

Energy Technology Data Exchange (ETDEWEB)

Platelets from dogs with Basset Hound Hereditary Thrombopathy (BHT) display a thrombasthenia-like aggregation defect but have been shown to have normal amounts of platelet membrane glycoproteins IIb and IIIa (GP IIb-IIIa). In order to investigate the possibility of a functionally abnormal GPIIb-IIIa complex, which might be unable to bind fibrinogen after stimulation, fibrinogen binding in BHT was evaluated. Two canine fibrinogen preparations were used, one from BHT dogs and one from normal control dogs, as well as a human fibrinogen preparation. Platelets from BHT and normal dogs were activated with 1 x 10/sup -5/M ADP in the presence of /sup 125/I-labeled fibrinogen and the surface bound radioactivity quantitated. For all fibrinogen preparations, the amount of fibrinogen bound by BHT platelets was not significantly different than that bound by normal dog ...

1986-03-01

5

Cloning and expression of a human kidney cDNA for an /alpha//sub 2/-adrenergic receptor subtype  

Energy Technology Data Exchange (ETDEWEB)

An /alpha//sub 2/-adrenergic receptor subtype has been cloned from a human kidney cDNA library using the gene for the human platelet /alpha//sub 2/-adrenergic receptor as a probe. The deduced amino acid sequence resembles the human platelet /alpha//sub 2/-adrenergic receptor and is consistent with the structure of other members of he family of guanine nucleotide-binding protein-coupled receptors. The cDNA was expressed in a mammalian cell line (COS-7), and the /alpha//sub 2/-adrenergic ligand (/sup 3/H)rauwolscine was bound. Competition curve analysis with a variety of adrenergic ligands suggests that this cDNA clone represents the /alpha//sub 2/B-adrenergic receptor. The gene for this receptor is on human chromosome 4, whereas the gene for the human platelet /alpha//sub 2/-adrenergic receptor (/alpha//sub 2/A) lies on ...

1988-09-01

6

Platelet receptor recognition domain on the. gamma. chain of human fibrinogen and its synthetic peptide analogues  

Energy Technology Data Exchange (ETDEWEB)

The authors have shown previously that the domain recognizing receptors on activated human platelets is located on the human fibrinogen {gamma} chain between residues 400 and 411. To study the correlation between the structure of this segment of the {gamma} chain and its reactivity toward receptors on ADP-activated human platelets, they designed a series of analogues containing replacements at 9 out of 12 positions. A double substitution of the normal His{sup 400}-His{sup 401} sequence by Ala-Ala reduced the inhibitory potency of the dodecapeptide 3-fold. When Lys{sup 406} was replaced by Arg, the inhibitory potency of the dodecapeptide decreased 15 times. On the other hand, substitution of Ala{sup 408} with Arg increased the inhibitory potency of the dodecapeptide 6-fold. A drastic decrease in the reactivity of the dodecapeptide toward platelet receptors was ...

1989-04-04

7

Developmentally regulated expression of a 78 kDa erythroblast membrane glycoprotein immunologically related to the platelet thrombospondin receptor.  

UK PubMed Central (United Kingdom)

We have previously described a monoclonal antibody (FA6-152), obtained by immunizing mice with fetal human erythrocytes [Edelman, Vinci, Villeval, Vainchenker, Henri, Miglierina, Rouger, Reviron, Breton-Gorius,...Full Text Available

1989-09-15

8

Storage of buffy-coat-derived platelets in additive solution: in vitro effects on platelets of the air bubbles and foam included in the final unit  

UK PubMed Central (United Kingdom)

Background.The air bubbles and foam that develop during the preparation of platelet units have traditionally been considered to interact with the platelets, causing activation and...Full Text Available

2011-04-01

9

Characterization of the platelet-aggregating activity of tumor cells. [Mice  

Energy Technology Data Exchange (ETDEWEB)

Two lines of mouse tumor cells were shown to be capable of aggregating mouse and rabbit platelets in vitro. This process required higher Mg/sup 2 +/ concentrations than were needed by other commonly used platelet-aggregating agents. Platelet-aggregating activity was also found in tumor cell membrane fragments. This membrane-bound platelet-aggregating material contained protein, lipid, and carbohydrate moieties. The presence of all three appeared to be essential for stimulating platelet aggregation. Destruction of any component abolished its activity. Platelet aggregation induced by tumor cell membrane fragments was associated with a secretory release reaction. In this process, growth-promoting activity for tumor cells was also released from platelets. These results underline the importance of platelets in establishing ...

1980-04-01

10

Measurement of 12(S)-hydroxy-5Z,8E,10E-heptadecatrienoic acid and its metabolite 12-oxo-5Z,8E,10E-heptadecatrienoic acid in human plasma by gas chromatography/negative ion chemical ionization mass spectrometry  

International Nuclear Information System (INIS)

Thromboxane A2, the predominant product of arachidonic acid metabolism in the blood platelet, is a potent vasoconstrictor and platelet agonist. During its biosynthesis from cyclic endoperoxide, 12(S)-hydroxy-5Z,8E,10E-heptadecatrienoic acid (HHT) is formed in equal amounts. The further metabolism of HHT, catalyzed by 15-hydroxyprostaglandin dehydrogenase, leads to 12-oxo-5Z,8E,10E-heptadecatrienoic acid (Oxo-HT). Sample workup procedures are described which allow for the sensitive and reproducible determination of these two arachidonic acid metabolites in human plasma by gas chromatography-mass spectrometry in the presence of deuterated analogues as internal standards. HHT is derivatized to the pentafluorobenzyl ester tert-butyldimethylsilyl ether. In order to enable quantification of low concentrations of about 10 pg/ml in nonstimulated human plasma, the samples have to be purified by HPLC. Oxo-HT is ...

1990-01-01

12

Quantification of the thrombogenicity of Dacron aortic prostheses  

International Nuclear Information System (INIS)

Eight patients with double-velour Dacron aorto-femoral grafts implanted for 2-60 months were studied. Indium-111-labelled platelets were found to have a shortened mean platelet lifespan (MPLS) of 138 +- 32 hours compared with the normal platelet lifespan of 224 +- 23 hours. Labelled platelets accumulated on all grafts, irrespective of graft age, to a maximum of 1,80 +- 0,83% of whole body radioactivity; thereafter graft radio-activity decreased. This suggests that platelets on the graft are in dynamic equilibrium with those in the circulation. Platelets may be lost from the graft by embolization or radioactivity may be released because of platelet lysis. Although MPLS may depend on the age and surface area of the graft, concomitant arterial disease probably also contributes to the shortened MPLS.

13

Generation of N-ethyl-N-nitrosourea-induced mouse mutants with deviations in hematological parameters  

British Library Electronic Table of Contents (United Kingdom)

Research on hematological disorders relies on suitable animal models. We retrospectively evaluated the use of the hematological parameters hematocrit (HCT), hemoglobin (HGB), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), mean corpuscular volume (MCV), red blood cell count (RBC), white blood cell count (WBC), and platelet count (PLT) in the phenotype-driven Munich N-ethyl-N-nitrosourea (ENU) mouse mutagenesis project as parameters for the generation of novel animal models for human diseases. The analysis was carried out on more than 16,000 G1 and G3 offspring of chemically mutagenized inbred C3H mice to detect dominant and recessive mutations leading to deviations in the levels of the chosen parameters. Identification of animals exhibiting altered valu...

2011-01-01

15

Radioisotopic techniques for noninvasive detection of platelet deposition in bovine-tissue mitral-valve prostheses and in vitro quantification of visceral microembolism in dogs  

International Nuclear Information System (INIS)

Platelet deposition on bovine pericardial-tissue mitral-valve prostheses in 11 dogs was observed noninvasively by use of "1"1"1In-labeled platelets and quantified after sacrifice at one (n . 3), 14 (n . 3), and 30 (n . 5) days postimplantation (300-400 microCi of labeled platelets having been injected 24 hours previously). Thrombosis on the sewing ring and pericardial leaflets at one and 14 days and on the leaflets at 30 days was delineated in scintiphotos. In vitro quantification (% injected dose) indicated that the leaflets, sewing ring, and perivalvular tissue retained 0.904% of labeled platelets at one day postimplantation, 0.198% at 14 days, and 0.040% at 30 days. Platelet half-life was reduced to 38 hours at 21 days postimplantation but returned toward the normal (50 hours) with fibrous ingrowth in the sewing ring. Microembolism in lung and kidney, as measured by tissue/blood ...

16

Platelets in Hyperacute Rejection of Heterotopic Cardiac Allografts in Presensitized Dogs  

UK PubMed Central (United Kingdom)

Experiments were carried out to determine whether platelet aggregation plays a primary role in cardiac allograft hyperacute rejection, as has been observed in renal allograft hyperacute rejection....Full Text Available

1973-02-01

17

Platelet-derived growth factor inhibits bone regeneration induced by osteogenin, a bone morphogenetic protein, in rat craniotomy defects.  

UK PubMed Central (United Kingdom)

Platelet-derived growth factor (PDGF) is a potent moderator of soft tissue repair through induction of the inflammatory phase of repair and subsequent enhanced collagen deposition. We examined the effect...Full Text Available

1993-12-01

18

Platelet thrombosis in cardiac-valve prostheses  

International Nuclear Information System (INIS)

The contribution of platelets and clotting factors in thrombosis on cardiovascular prostheses had been quantified with several tracers. Thrombus formation in vivo could be measured semiquantitatively in animal models and patients with indium-111, Technetium-99m labeled platelets, iodine-123, iodine-131 labeled fibrinogen, and In-111 and Tc-99m labeled antibody to the fibrinogen-receptor on the platelet- membrane, or fibrin. The early studies demonstrated that certain platelet-inhibitors, e.g. sulfinpyrazone, aspirin or aspirin- persantine increased platelet survival time with mechanical valves implanted in the baboon model and patients. Thrombus localization by imaging is possible for large thrombus on thrombogenic surface of prosthesis in the acute phase. The majority of thrombus was found in the sewing ring (Dacron) in the acute phase in both the mechanical and tissue valves. The ...

1989-06-08

19

Considerable Variability in Platelet Activity among Patients with Coronary Artery Disease in Response to an Increased Maintenance Dose of Clopidogrel  

UK PubMed Central (United Kingdom)

BackgroundVariable platelet response to clopidogrel has been widely observed. Studies have shown that the mean aggregation response to clopidogrel can be changed...Full Text Available

2009-05-01

20

Cangrelor increases the magnitude of platelet inhibition and reduces interindividual variability in clopidogrel-pretreated subjects  

UK PubMed Central (United Kingdom)

BackgroundInadequate platelet inhibition despite aspirin and clopidogrel therapy during and after a percutaneous coronary intervention is associated with an impaired clinical outcome....Full Text Available

2009-05-01

21

Autologous Platelet-Rich Plasma Mixed with Purified Fat Graft in Aesthetic Plastic Surgery  

British Library Electronic Table of Contents (United Kingdom)

Platelet-rich plasma (PRP) is a platelet concentrate that has widely been used to accelerate the healing of soft and hard tissues. The preparation of PRP has been described by several authors. Preparation protocols vary from system to system, depending on the concentration of different integrating proteins. The objective of this article is to describe the principal use of PRP mixed with fat grafts in aesthetic plastic surgery.

2009-01-01

22

Engineering Task Plan for Water Supply for RMCS Spray Wash Trailer  

Energy Technology Data Exchange (ETDEWEB)

This ETP defines the task and deliverables associated with the design, fabrication and testing of an improved spray wash system for the Rotary Mode Core Sampling (RMCS)Spray Wash Trailer.

2000-04-20

23

The wash-off of dyeings using interstitial water part 1: Initial studies  

British Library Electronic Table of Contents (United Kingdom)

The extent to which a novel wash-off process using polyamide beads removed five different types of dye from three different types of fibre was similar to that achieved using conventional aftertreatments. Whilst bead wash-off and the conventional aftertreatments were of similar duration and temperature, conventional aftertreatment employed a 10:1 or 20:1 liquor ratio whereas bead wash-off used a < 1:1 liquor ratio. As vagrant dye was adsorbed onto the bead material during wash-off, the low amount of wastewater generated contained little residual dye, thereby offering the potential of reduced environmental and cost benefits. Bead wash-off did not impair the fastness of two non-metallised acid dyes on nylon 6,6 to washing at 60 ?C.

2011-01-01

24

Process for producing calcium sulfate dihydrate during desulfurization of stack gases from power station boilers. Verfahren zur Herstellung von Calciumsulfat-Dihydrat im Zuge der Entschwefelung von Rauchgasen aus Kraftwerkskesselfeuerungen  

Energy Technology Data Exchange (ETDEWEB)

This is a process for producing calcium sulfate dihydrate during desulfurization of stack gases from power station boilers, where the stack gases are introduced into a washing tower and are treated with a washing water suspension containing lime in the washing tower, where oxygen in the form of air or of air enriched in oxygen is also blown into the washing tower, and where the washing water suspension drawn off from the washing tower is fed back to the washing tower at a temperature of 45 to 50/sup 0/C in the circuit and at least part of the flow goes via a thickener and where calcium sulfate dihydrate slurry is drawn off from the thickener.

1986-06-12

25

Microstructural features in sintered Si_3N_4/SiC platelets systems  

International Nuclear Information System (INIS)

Analytical TEM and high resolution TEM were used in the microstructural characterization of hot-press sintered Si_3N_4-SiC platelets composites. The quantity of sintering additives, Er_2O_3 and AlN, was varied to produce different matrices, e. g. Si_3N_4, #beta#'+#alpha#'-Sialon and #alpha#'-Sialon. Detailed analysis of platelet-sialon matrix interfaces revealed the presence of AlN polytypoids. The polytypoids nucleate preferentially onto the (0001) plane of SiC and growth epitaxially in several ten nanometer layers contributing in this way to crystallize, partially, the matrix intergranular glass pockets contacting the platelets. Possible applications of the phenomena to microstructural control, grain boundary phase control and enhanced creep resistance are discussed. (orig.).

1993-10-04

26

Effect of differentiation on specific receptor sites and endocytosis of transferrin in a cell (HT-29) derived from human colic adenocarcinoma  

International Nuclear Information System (INIS)

The specific receptor sites and the endocytosis of transferrin (Tf) are evidenced in a cell line (HT-29) derived from a human colic adenocarcinoma by means of "1"2"5I radiolabeled Tf. The receptor density is studied in undifferentiated (UD) or differentiated (D) cells with respective doubling times of about 24 hours and 46 hours. The number of binding sites for Tf is 162,000 (K_d = 7.8 nmol/l in ND cells and 68,000 (K_d = 7.40 nmol/l) in D cells. The distribution between the Tf bound to the cell surface and the internalized Tf is investigated by elimination of Tf bound to the surface by an acid wash method. The intracellular cycle of Tf seems to be characterized by a slower kinetics in UD cells. The high density of Tf receptor sites in HT-29 UD cells should allow the detection or the treatment of highly evolutive colic adenocarcinoma by means of Tf.

27

Diminished osmotic fragility of human erythrocytes following the membrane insertion of oxygenated sterol compounds  

Energy Technology Data Exchange (ETDEWEB)

Oxygenated sterol compounds (OSC), when incubated for 1 hr with human erythrocytes in lipoprotein-depleted medium at concentrations of 0.625-5 x 10/sup -5/M, are inserted into the cell membrane and remain there despite subsequent washing of the cells. The insertion results in expansion of the surface area of the red cell ghost membrane, an increase in critical hemolytic volume, and as a consequence, in dimished osmotic fragility of the erythrocytes. This effect is seen with echinocyte-forming as well as with non-echinocyte-forming OSC. Erythrocytes treated with OSC do not differ from control cells with respect to their mean cell volume (MCV) in isotonic solution, water content, ion fluxes, and filterability through polycarbonate filters. The shift of the osmotic fragility curve toward lower NaCl concentrations is proportional to the amount of OSC inserted into the red cell membrane. 7BETA-Hydroxycholesterol, 22-ketocholesterol, and 20 ..cap ...

1981-08-01

28

Platelet-activating factor mediates hemodynamic changes and lung injury in endotoxin-treated rats.  

UK PubMed Central (United Kingdom)

Within 20 min after intraperitoneal injection of Salmonella enteritidis endotoxin in rats, blood platelet-activating factor (PAF) increased from 4.3 +/- 1.3 to 13.7 +/- 2.0 ng/ml (P less than 0.01)...Full Text Available

1987-05-01

29

Removal of lead from solution using non-living residual brewery yeast  

Energy Technology Data Exchange (ETDEWEB)

A number of preparations of residual non-living brewery yeast were examined for their ability to remove lead from solution. Those preparations included washed and un-washed intact yeast and washed and un-washed homogenates of the yeast cells. Using biosorption isotherm analysis it was found that the washed and un-washed preparations of intact, non-living yeast exhibited maximum biosorption capacities for lead of 127 and 99 mg/g dry weight biomass, respectively. The washed and un-washed cell homogenates exhibited maximum biosorption capacities of 38 and 139 mg lead/g dry weight biomass, respectively. Since it had previously been shown that these preparations of biomass were capable of removing uranium from solution by combined biosorption and precipitation processes, it was decided to examine removal of lead from solution ...

1998-10-01

31

A b s t r a c t Vo l u m e  

Wastenet

deodorants and sportswear and silver in washing ma- chines, refrigerators, health care products,

32

Simple chemical method for nanoporous network of In2S3 platelets for buffer layer in CIS solar cells  

British Library Electronic Table of Contents (United Kingdom)

Indium sulfide thin films consisting of porous network of nanoplatelets, have been deposited using chemical bath deposition (CBD) method onto the tin-doped indium oxide (ITO) coated glass substrate. Aqueous solutions of indium sulfate and thioacetamide have been used as indium and sulfur precursors. As a complexing agent, acetic acid was used. The chemically deposited indium sulfide thin films were examined for their structural, surface morphological and optical characterizations. The X-ray diffraction analysis revealed the formation of the cubic b-In2S3 onto the substrate. From scanning electron micrograph, it is observed that the surface of substrate is covered by nanoporous platelets type morphology. The optical studies showed a direct band gap of 2.84eV for indium sulfide platelets. Ph...

2008-01-01

33

Effect of Si_3N_4 whisker and SiC platelet addition on phase transformation and mechanical properties of the #alpha#/#beta# sialon matrix composites  

International Nuclear Information System (INIS)

#alpha#/#beta# sialon based composites containing silicon nitride whisker and silicon carbide platelet were fabricated by hot pressing. Effect of the reinforcing agents on the #alpha# to #beta# phase transformation of the sialon as well as on the mechanical properties was investigated. Silicon nitride whisker and silicon carbide platelet promoted the phase transformation. TEM/EDS analysis revealed that the grain containing the whisker had 'core-rim' structure; core being high purity Si_3N_4 whisker and rim being #beta#-sialon. Flexural strength of the composite decreased with the reinforcement addition which, on the other hand, improved fracture toughness of it. High temperature strength was measured at 1300 deg C to be about 130 MPa lower than that measured at RT for the whisker reinforced composite. (author).

34

Biological effects of exogenous adenosine 5 prime -triphosphate on cultured mammalian cells: Evidence for a receptor mechanism and its regulation by desensitization  

Energy Technology Data Exchange (ETDEWEB)

Exogenous adenosine 5{prime}-triphosphate (ATP) mobilized intracellular calcium in human carcinoma A43l cells and in Swiss 3T3 and 3T6 mouse fibroblasts by increasing inositol trisphosphate similar to well down growth factors (platelet-derived growth factor (PDGF), epidermal growth factor (EGF), bradykinin (BK), serum). Calcium mobilization was examined by video imaging of fura-2 fluorescence is single cells, following the radioactive isotope {sup 45}Ca, and monitoring the decrease in fluorescence of cells loaded with chlortetracycline. Uridine 5{prime}-triphosphate, but not other nucleotides, mimicked ATP. Single-cell analysis revealed synchronous responses in 10 sec to ATP, BK or serum, while PDGF (3T3) and EGF (A431) produced slower signals with significant cell-to-cell variation. PDGF desensitized 3T3 cells to ATP and BK added 100 sec later but ATP or BK did not desensitized to PDGF. Homologous desensitization was seen with all agonists. ...

1989-01-01

35

Phylogenetic constraints on digesta separation: Variation in fluid throughput in the digestive tract in mammalian herbivores  

British Library Electronic Table of Contents (United Kingdom)

The relevance of the mean retention time (MRT) of particles through the gastrointestinal tract (GIT) is well understood and MRTparticleGIT is an important parameter in digestion models. Solute markers have been used to estimate MRTsoluteGIT (or 'fluid passage') in animals, but the relevance of this measure is less evident and is usually sought in its relation to MRTparticleGIT. The ratio between the two measures indicates the degree of 'digesta washing', with little washing occurring at ratios of 1, aborad washing at ratios >1 (where the solute marker travels faster than the particle marker), and orad (retrograde) washing at ratios <1 (where the solute marker travels slower than the particle marker). We analysed digesta washing in a dataset of 98 mammalian species including man of differen...

2011-01-01

36

Risk factors for thrombosis in lupus patients.  

UK PubMed Central (United Kingdom)

Lupus anticoagulant, concentrations of anticardiolipin antibodies, antithrombin III, plasminogen, (free) protein S, protein C, prothrombin, platelet counts, and bleeding times were determined in 74...Full Text Available

1989-11-01

38

Abciximab: a reappraisal of its use in coronary care  

UK PubMed Central (United Kingdom)

Platelet reactivity plays a pivotal role in the pathogenesis of ischemic adverse events during and after acute coronary syndromes (ACS), and percutaneous coronary intervention (PCI). Glycoprotein (GP)...Full Text Available

2008-03-01

39

A Randomized Clinical Trial Investigating the Relationship Between Aprotinin and Hypercoagulability in Off-Pump Coronary Surgery  

UK PubMed Central (United Kingdom)

BACKGROUNDOff-pump coronary artery bypass (OPCAB) surgery is associated with a hypercoagulable state in which the platelet thrombin receptor, protease-activated receptor-1...Full Text Available

2009-11-01

40

Enhanced sludge washing evaluation plan  

Energy Technology Data Exchange (ETDEWEB)

The Tank Waste Remediation System (TWRS) Program mission is to store, treat, and immobilize highly radioactive Hanford Site waste (current and future tank waste and the strontium/cesium capsules) in an environmentally sound, safe, and cost-effective manner. The scope of the TWRS Waste Pretreatment Program is to treat tank waste and separate that waste into HLW and LLW fractions and provide additional treatment as required to feed LLW and HLW immobilization facilities. Enhanced sludge washing was chosen as the baseline process for separating Hanford tank waste sludge. Section 1.0 briefly discusses the purpose of the evaluation plan and provides the background that led to the choice of enhanced sludge washing as the baseline process. Section 2.0 provides a brief summary of the evaluation plan details. Section 3.0 discusses, in some detail, the technical work planned to support the evaluation of enhanced sludge washing. ...

1994-09-01

41

The Factors Determining the Level of Virus Production. Report ...  

Science.gov (United States)

... After formation of the monolayer (usually in 48 hours), the growth medium was poured off, and the cells washed twice with a Henkes solution and ...

1971-12-02

42

Status and progress in sludge washing: A pivotal pretreatment method  

Energy Technology Data Exchange (ETDEWEB)

Separation of the bulk soluble chemical salts from the insoluble metal hydroxides and radionuclides is central to the strategy of disposing Hanford tank waste. Sludge washing and caustic leaching have been selected as the primary methods for processing the 230 million L (61,000,000 gal) of Hanford tank waste. These processes are very similar to those selected for processing waste at the West Valley Site in New York and the Savannah River Site in South Carolina. The purpose of sludge washing is to dissolve and remove the soluble salts in the waste. Leaching of the insoluble solids with caustic will be used to dissolve aluminum hydroxide and chromium hydroxide, and convert insoluble bismuth phosphate to soluble phosphate. The waste will be separated into a high-level solids fraction and a liquid fraction that can be disposed of as low-level waste after cesium removal. The washing and leaching operations involve batchwise ...

1995-01-01

43

Loss of cell components during rehydration of dried Rhodotorula glutinis and its implications for lead uptake  

British Library Electronic Table of Contents (United Kingdom)

Abstract Microbial cells are routinely dried and ground before they are used in metal biosorption studies. In this work, a metal biosorbent was prepared by drying biomass of the yeast Rhodotorula glutinis in an oven at 70C for 24-h followed by grinding. Two forms of the prepared biosorbent particles, washed and unwashed, were examined for their ability to remove lead from solution. It was found that the unwashed biosorbent exhibited higher lead uptake than the washed biosorbent. Analysis of the supernatant of washed cells incubated in water and that of unwashed cells incubated in lead solution revealed the presence of protein, carbohydrates, organic acids and inorganic phosphate. Overall, the washed and unwashed cells leached, respectively, 14.5 and 13.4% of their initial dry weight (100-m...

2011-01-01

45

Density Gradients for Isolation of Mononuclear Blood Cells for ...  

Science.gov (United States)

... to-continuum X-ray intensity ratio [5]. For ence in the means [7]. In addition, washing samples on thin films, the characteristic X- lymphocytes in NH ...

2011-05-15

46

DEGRADED TBP SOLVENT REGENERATION TECHNOLOGY USING BUTYLAMINE AS A SOLVENT WASHING TO REDUCE SOLID SALT WASTE  

Energy Technology Data Exchange (ETDEWEB)

Normal butylamine compounds are studied as salt-free wash reagents for degraded solvent used in PUREX process in spent fuel reprocessing. The solvent wash tests were carried out with two types of butylamine compounds, n-butylamine oxalate and n-butylamine bicarbonate, by counter-current mode using a small size mixer-settler composed of two 4-stage wash steps. Di-n-butyl phosphoric acid (HDBP), the main degradation product from TBP, was removed from real degraded solvent with decontamination factor of 2.5 {approx} 7.9. The study on electrolytic decomposition of butylamine compounds was also conducted for waste treatment.

2003-02-27

47

As DeltaMarks Success No. 22 - NASA  

Science.gov (United States)

82nd Airborne Division Vet- erans, which has about 3000 members. A native Washing- tonian, Bob, his wife Geraldine and their four children live in ...

48

A METHOD OF PROTECTING METAL POWDERS FROM ...  

Science.gov (United States)

... Two lots of' manganes* powder were treated by Pichra~te Treatment A Appendir i I n which the mnanese -ens washed *wih distIllel enter on a ...

1951-04-18

49

Short-term inhibition of ADP-induced platelet aggregation by clopidogrel ameliorates radiation-induced toxicity in rat small intestine.  

Science.gov (United States)

Endothelial dysfunction and increased platelet aggregation may be involved in the pathogenesis of normal tissue radiation toxicity. This study assessed clopidogrel, an inhibitor of ADP-induced platelet aggregation, as a modulator of intestinal radiation injury (radiation enteropathy). Rat small intestine was exposed to 21 Gy X-radiation. Clopidogrel (20 mg/kg/day) or vehicle was administered from 2 days before to 10 days after irradiation. Structural radiation injury, neutrophil infiltration, smooth muscle cell proliferation, collagen content, and TGF-beta1 expression were assessed 2 weeks (early phase) and 26 weeks (delayed phase) after irradiation, using quantitative histology and immunohistochemistry, morphometry, and real-time fluorogenic probe RT-PCR. Irradiated intestine exhibited significant histopathologic injury, reduced mucosal surface area, vascular sclerosis, intestinal wall fibrosis, increased collagen content, and increased ...

2002-01-01

50

Antihemostatic molecules from saliva of blood-feeding arthropods.  

Science.gov (United States)

The ability to feed on vertebrate blood has evolved many times in various arthropod clades. Each time this trait evolves, novel solutions to the problem posed by vertebrate hemostasis are generated. Consequently, saliva of blood-feeding arthropods has proven to be a rich source of antihemostatic molecules. Vasodilators include nitrophorins (nitric oxide storage and transport heme proteins), a variety of peptides that mimic endogenous vasodilatory neuropeptides, and proteins that catabolize or sequester endogenous vasoconstrictors. A variety of platelet aggregation inhibitors antagonize platelet responses to wound-generated signals, including ADP, thrombin, and collagen. Anticoagulants disrupt elements of both the intrinsic and extrinsic pathways. Molecular approaches (termed 'sialomics') to characterize the full inventory of mRNAs transcribed in salivary glands have revealed a surprising level of complexity within a single species. Multiple ...

2005-01-01

51

A method of producing a stabilizer of wash drilling muds  

Energy Technology Data Exchange (ETDEWEB)

A method is proposed for producing a stabilizer of wash drilling muds; by hydrolysis of polyacrylonitrile in an aqueous solution of alkaline agent with heating. To raise the heat resistance of the stabilizer, as the alkaline agent is used monosilicate of sodium, while the hydrolysis is done at a molar ratio of polyacrylonitrile, sodium monosilicate and water equal to 1.0:0.7-2.5:100, to a degree of hydrolysis of 25-40.

1981-01-01

52

Murine antibody response to oral infection with live aroA recombinant Salmonella dublin vaccine strains expressing filamentous hemagglutinin antigen from Bordetella pertussis.  

Science.gov (United States)

Two plasmids which express either nearly intact or truncated filamentous hemagglutinin (FHA) from Bordetella pertussis and which are marked with a tetracycline resistance (Tcr) gene were transformed into Salmonella dublin SL1438, an aroA deletion mutant intended for use as an attenuated oral vaccine against salmonellosis. These S. dublin recombinants, when fed to mice, induced serum immunoglobulin, immunoglobulin M (IgM), and sometimes IgA antibody responses to FHA and S. dublin. In addition, IgA antibodies against FHA were found in gut wash fluids. S. dublin carrying pDB2300, a multicopy plasmid encoding truncated FHA protein, induced a better antibody response than did S. dublin carrying pDB2000, a low-copy-number plasmid encoding full-sized FHA. Administration of tetracycline to mice enhanced the stability of recombinant plasmids, and tetracycline-treated mice developed higher anti-FHA titers. Although neither strain examined is suitable for use in a ...

1990-08-01

53

Determination of sodium in biological samples by instrumental neutron activation analysis  

International Nuclear Information System (INIS)

Sodium is one of the most essential elements needed for metabolic processes amongst human beings. It is consumed in the form of sodium chloride but it is also present in edible plant leaves. Sodium is mostly analyzed by flame photometric method, a destructive and time consuming technique. Sodium has been determined in some green leave vegetables samples-palak, radish, khatta palak (ambat chuka), chaulai leaves, chauli bean covers and its seeds by instrumental neutron activation analysis. The method involves irradiation of samples with thermal neutrons from "2"4"1Am-Be source and counting "2"4Na activity (half life 15 hr) from the reaction "2"3Na(n,#gamma#) "2"4Na. Activity due to 1.37 MeV photopeak was counted with a NaI(Tl) crystal coupled to gamma ray spectrometer. Green leaves of the vegetables were thoroughly washed, dried at constant temperature and powdered. Bowen's Kale powder was used as standard for measuring sodium abundances. About ...

1981-05-01

54

Use of platelet glycoprotein IIb/IIIa inhibitors in diabetics undergoing PCI for non-ST-segment elevation acute coronary syndromes: impact of clinical status and procedural characteristics  

UK PubMed Central (United Kingdom)

BackgroundThe most recent ESC guidelines for percutaneous coronary intervention (PCI) recommend the use of glycoprotein IIb/IIIa inhibitors (GPI) in high risk patients with non-ST-segment...Full Text Available

2010-06-01

55

Strategies for gallium removal after focused ion beam patterning of ferroelectric oxide nanostructures  

International Nuclear Information System (INIS)

As part of a study into the properties of ferroelectric single crystals at nanoscale dimensions, the effects that focused ion beam (FIB) processing can have, in terms of structural damage and ion implantation, on perovskite oxide materials has been examined, and a post-processing procedure developed to remove such effects. Single crystal material of the perovskite ferroelectric barium titanate (BaTiO_3) has been patterned into thin film lamellae structures using a FIB microscope. Previous work had shown that FIB patterning induced gallium impregnation and associated creation of amorphous layers in a surface region of the single crystal material some 20 nm thick, but that both recrystallization and expulsion of gallium could be achieved through thermal annealing in air. Here we confirm this observation, but find that thermally induced gallium expulsion is associated with the formation of gallium-rich platelets on the surface of the annealed material. These ...

2007-01-24

56

Myeloid-Related Protein-8/14 and the Risk of Cardiovascular Death or Myocardial Infarction after an Acute Coronary Syndrome in the PROVE IT-TIMI 22 Trial  

UK PubMed Central (United Kingdom)

BackgroundUsing a transcriptional profiling approach, we recently identified myeloid-related protein-8/14 (MRP-8/14) to be expressed by platelets during acute MI....Full Text Available

2008-01-01

57

Estimation tests for effecting factor on decontamination property in crystallization process  

International Nuclear Information System (INIS)

Crystallization procedure is considered to have adaptability to new reprocessing process based on the PUREX process because it has an advantage in recovering rather pure uranium from contaminated uranium solution without reagent. NEXT (New Extraction System for TRU Recovery) process has been developed by JNC, and applying the crystallization process unit to NEXT process has a capability to contribute to an improvement of economical efficiency and reduction of liquid waste in NEXT process. Thus following studies were carried out. In crystallization process unit, UNH (Uranyl Nitrate Hydrate)-crystals are washed by a nitric acid solution to get high decontamination factor, but the data on UNH-crystals dissolution by washing procedure is insufficient to evaluate the effectiveness of crystallization process unit. So, in this study, the effect of a nitric acid concentration to UNH-crystals dissolution and decontamination factor was tested. As ...

58

Investigation of the removal efficiency of gasborne particles in a scrubber column  

Energy Technology Data Exchange (ETDEWEB)

Tests on the scrubbing column have led to the following results: Use of a scrubbing column with Raschig rings is only meaningful for the sedimentation of particles exceeding diameters of 0.5 ..mu..m; drops of diameter size 1.5 ..mu..m are formed in the column; more efficient drop precipitators in the column air flow ease the load on subsequent suspended material filters thereby contributing to a longer life of these filters even at higher sodium ion concentrations in the washing water; with distillate of an 8% rather than 0.8% salt solution a decontamination factor greater than 10 can be calculated since larger particles precipitate more readily. This only applies, however, under the condition that the washing water is renewed regularly, if necessary daily where higher aerosol concentrations are present. If not, the decontamination factor will be reduced through the salt-containing secondary aerosols from the washing water.

1983-01-01

59

Investigation of the removal efficiency of gasborne particles in a scrubber column  

International Nuclear Information System (INIS)

Tests on the scrubbing column have led to the following results: Use of a scrubbing column with Raschig rings is only meaningful for the sedimentation of particles exceeding diameters of 0.5 #mu#m; drops of diameter size 1.5 #mu#m are formed in the column; more efficient drop precipitators in the column air flow ease the load on subsequent suspended material filters thereby contributing to a longer life of these filters even at higher sodium ion concentrations in the washing water; with distillate of an 8% rather than 0.8% salt solution a decontamination factor greater than 10 can be calculated since larger particles precipitate more readily. This only applies, however, under the condition that the washing water is renewed regularly, if necessary daily where higher aerosol concentrations are present. If not, the decontamination factor will be reduced through the salt-containing secondary aerosols from the washing water. ...

61

Reduction of Selenate to Selenide by Sulfate-Respiring Bacteria: Experiments with Cell Suspensions and Estuarine Sediments  

UK PubMed Central (United Kingdom)

Washed cell suspensions of Desulfovibrio desulfuricans subsp. aestuarii were capable of reducing nanomolar levels of selenate to selenide as well as sulfate to sulfide....Full Text Available

1987-06-01

62

Legionella lansingensis sp. nov. isolated from a patient with pneumonia and underlying chronic lymphocytic leukemia.  

UK PubMed Central (United Kingdom)

A Legionella-like organism, strain 1677-MI-H, was isolated from the bronchoscopy washings of a patient with pneumonia who had a 2-year history of progressive, chronic lymphocytic leukemia. The growth...Full Text Available

1992-09-01

63

Factors affecting the aggregation of Actinomyces naeslundii during growth and in washed cell suspensions.  

UK PubMed Central (United Kingdom)

Various factors affecting the aggregation of Actinomyces naeslundii strain 12104 were studied. When the pH of glucose-supplemented growth medium fell below 5.5, the cells aggregated and formed microbial...Full Text Available

1978-09-01

65

Development of non-phosphate detergent with zeolite and. alpha. -olefin sulfonate. Zeolite-AOS ni yoru senzai no murinka  

Energy Technology Data Exchange (ETDEWEB)

Development was explained of non-phosphate detergent with zeolite (Z) and alpha-olefin sulfonate (AOS). 4A type Z was taken notice of as a builder to replace phosphate. In calcium ion trapping power, conventional sodium tripolyphosphate (STP) and Z are 158mgCaO/g and 150mg/g, respectively. However, because Z by the conventional method is large in crystal diameter, coagulates and adheres to matter to be washed, was newly developed fine Z, 0.9 {mu} m in primary grain diameter, which does not give abrasion nor occlusion to the washing machine, nor precipitate in the river. Because linear alkylbenzene sulfonate, combined with Z, is poorer in washing power than that, done with STP, was developed AOS, new non-phoshate use interfacial active detergent, which is excellent in all washing power, biodegradation speed and physical powder property. Improvement was variously made also in powdery detergent production ...

1990-07-01

66

Low-temperature technology for high-grade products from coal  

Energy Technology Data Exchange (ETDEWEB)

Gasification and hydrogenation are the two basic routes for coal processing. Accounts are given of various low-temperature processes in coal gasification route A: air separation, removal of sour gas by the Rectisol process, liquid nitrogen washing, the material balance and utility consumption of these processes, plus low-temperature gas separation, partial condensation and methane washing. There are also accounts of the low-temperature processes involved in gasification route B: i.e., in the indirect coal liquefaction and direct liquefaction carried out in the Sasol II and III processes. (3 refs.) (In Japanese)

1982-01-01

67

High-level waste tank modifications, installation of mobilization equipment/check out  

Energy Technology Data Exchange (ETDEWEB)

PUREX high-level waste (HLW) is contained at the West Valley Demonstration Project (WVDP) in an underground carbon-steel storage tank. The HLW consists of a precipitated sludge and an alkaline supernate. This report describes the system that the WVDP has developed and implemented to resuspend and wash the HLW sludge from the tank. The report discusses Sludge Mobilization and Wash System (SMWS) equipment design, installation, and testing. The storage tank required modifications to accommodate the SMWS. These modifications are discussed as well.

1992-08-31

68

Development of the alcohol waste processing equipment  

International Nuclear Information System (INIS)

In the experimental fast Reactor JOYO, gripper of Fuel Handling Machine and Ex-Vessel Transfer Machine that the sodium adhered is being washed with alcohol. This radioactive alcohol waste that was used to the washing is stored to the tank. If it is able to separate the alcohol and sodium in the alcohol waste it becomes possible to dispose of the alcohol waste. Japan Nuclear Institute and Fuji Electric Systems CO., LTD. Developed the device that adds carbonic acid gas to the alcohol waste and cause the sodium in the alcohol waste separated as carbonate and remove this carbonate by using the thin film evaporator. (author)

2004-11-01

69

Adsorption properties of. cap alpha. -modification of boron nitride  

Science.gov (United States)

The adsorption properties of four samples of ..cap alpha..-BN were studied by means of gas chromatography. The particles of ..cap alpha..-BN particles, according to data obtained by electron microscopy, have the shape of thin platelets. A sample of ..cap alpha..-BN prepared from magnesium polyboride was found to be the most nearly homogeneous adsorbent. For a number of n-alkanes, benzene, and alkylbenzenes, data have been obtained on the retention volumes (Henry constants) and the differential heats of adsorption for surface coverages approaching zero. These thermodynamic data on the adsorption showed that ..cap alpha..-BN, like graphitized thermal carbon black, is a nonspecific adsorbent.

1986-11-01

72

Economics of scale versus completion risks, Cottonwood Wash oil shale project, Uinta Basin, Utah  

Energy Technology Data Exchange (ETDEWEB)

The major problem plaguing the synfuels industry is the financing of large capital requirements in a technologically unproven field. This is exemplified by the 2 to 3 billion dollar investment required by oil shale development. Despite an unquestionable resource which is well characterized and a wealth of information from processes which have undergone extensive pilot development work, financing of a project is difficult because of the risk. In recent studies on a worldwide basis as a background for evaluating the Cottonwood Wash project in the Uinta Basin, Utah, the concept of small scale or modular development of this type of resource can lead to acceptable economics with a substantially higher probability of actual completion. This study discusses Uinta Basin oil shale resources and current developments and evaluates the economics of small scale or modular development for the Cottonwood Wash project processes. This evaluation shows the ...

1982-05-01

73

Late cenozoic evolution of Fortymile Wash: Major change in drainage pattern in the Yucca Mountain, Nevada region during late miocene volcanism  

International Nuclear Information System (INIS)

The site characterization of Yucca Mountain, NV as a potential high level nuclear waste repository includes study of the surficial deposits as a record of the paleoenvironmental history of the Yucca Mountain region. An important aspect of this history is an understanding of the evolution of paleogeography leading to establishment of the present drainage pattern. Establishment of drainage basin evolution is needed before geomorphic response to paleoclimate and tectonics can be assessed, because a major change in drainage basin geometry can predominantly affect the sedimentary record. Because alluvial aquifers are significant to regional hydrology, a major change in surface drainage resulting in buried alluvium could have hydrogeologic significance. In this paper, we report on geologic evidence for a major modification in surface drainage pattern in the Yucca Mountain region, resulting in the probable establishment of the Fortymile Wash drainage basin by latest ...

1994-05-22

74

Exposure data for personal care products: Hairspray, spray perfume, liquid foundation, shampoo, body wash, and solid antiperspirant  

British Library Electronic Table of Contents (United Kingdom)

Reliable exposure information for cosmetic and other personal care products and ingredients is needed in order to conduct safety assessments. Essential information includes both the amount of product applied, and the frequency of use. To obtain current data, studies to assess consumer use practices were undertaken. Six widely used personal care product types were included in the studies. Five of the products were cosmetics (spray perfume, hairspray, liquid foundation, shampoo, body wash) and one product was a cosmetic/over-the-counter drug product (solid antiperspirant). Three hundred and sixty women, ages 19-65 years, who regularly use the products of interest, were recruited at 10 different geographical locations within the US. The number of recruits was chosen to ensure a minimum of thr...

2006-01-01

75

Synthetic Biology and Human Health: Potential Applications for Spaceflight  

Science.gov (United States)

Human space travelers experience a unique environment that affects homeostasis and physiologic

2011-01-01

76

Immunohistochemical expression of p63 in human prenatal tooth primordia  

DEFF Research Database (Denmark)

development, histochemical, human, malformation, p63 gene, tooth

2005-01-01

77

Human Waste Handling-Kooyman  

Science.gov (United States)

... wood, kitchen wastes, and human faeces with the ash from such burning deposited and retained in an ...

78

3 CFR - Guidelines for Human Stem Cell Research  

Science.gov (United States)

...false Guidelines for Human Stem Cell Research Presidential Documents ...2009 Guidelines for Human Stem Cell Research Memorandum for the Heads...scientifically worthy human stem cell research, including human...

2010-01-01

79

Use of magnetic treatment to intensify certain processes in the refining of chemical products of coking  

Energy Technology Data Exchange (ETDEWEB)

The results of the investigations show that magnetic treatment is a quite practical and effective method of intensifying certain technological processes in the coking industry. Magnetic treatment was utilized for improving the production of ammonium sulfate, refining of the naphthalene fraction, removal of sludge from wash oil in the benzol division, and the treatment of tar before fractionation. 2 references, 3 tables.

1983-01-01

80

The research on new production technique of yellow cake  

International Nuclear Information System (INIS)

As a new production technique of yellow cake, resorption with loaded resin-elution with acid ammonium nitrate-precipitation in two steps is studied. The results show that the produced yellow cake by the new production technique has better performance of settlement, filtration and dehydration. Each index of yellow cake accords with the first grade level issued by CNNC without washing, uranium and water content are 70% and 25%, respectively

2001-11-01

81

Removal of noxious contaminants from gas  

Science.gov (United States)

Gas contaminated with at least one noxious component, such as SO/sub 2/, HF or NOx, is scrubbed with a clear, calcium-containing, initially-basic washing liquid which also comprises the anion of a strong inorganic acid, that of a polybasic carboxylic acid and, optionally, that of a monobasic carboxylic acid. Apparatus is provided for scrubbing the gas, oxidizing produced calcium bisulfite to calcium sulfate, separating out and removing solids, and recirculating clarified liquid for scrubbing contaminated gas.

1980-09-16

82

Recent process developments at the COMINAK uranium mill  

Energy Technology Data Exchange (ETDEWEB)

This paper reviews the mill flowsheet applied at the COMINAK uranium mill (Compagnie Miniere d'Akouta) in Niger. For ore treatment, it focuses on the major improvements to the operations using sulfonitric pugging and solids/liquid separation using belt filter double filtration after leaching. The precipitation circuits have been improved with molybdenum elimination through caustic washing of the yellow cake. (author)

2000-07-01

83

Method of removing hydrogen sulfide from gases utilizing a polyvalent metal chelate of nitrilotriacetic acid and electrolytically regenerating the solution  

Energy Technology Data Exchange (ETDEWEB)

A process for the removal of H/sub 2/S from sour gas streams is disclosed, the process being characterized by the utilization of washing solutions containing oxidizing metal chelates of nitrilotriacetic acid, and by the electrolytic regeneration of the spent solutions.

1984-03-13

84

Inflation in Bianchi models and the cosmic no hair theorem in a brane world  

International Nuclear Information System (INIS)

The cosmic no hair theorem is studied in anisotropic brane worlds. Assuming anisotropic Bianchi models with an inflaton field it is shown that, during slow-roll inflation, anisotropy in all Bianchi models except a Bianchi type-IX universe washes out. Brane worlds admit both exponential and power law inflation. We consider here only exponential expansion of the universe. It is found that isotropization occurs much faster in a brane world than in the general theory of relativity.

2002-12-15

85

BIBRA "t"r"a"d"e"m"a"r"k - the biological treatment of radioactive waste water  

International Nuclear Information System (INIS)

BIBRA "t"r"a"d"e"m"a"r"k, is the new bio-technological method developed in Gundremmingen for treating radioactive waste water, using bacteria in a process analogous to the long-established principle of communal sewage treatment plants. The method exploits the behaviour of the micro-organisms found there, to establish optimum adaptation of their population for decomposing the typical pollutants found in this washing water. This procedure is particularly suitable for nuclear engineering plants, because in such plants the waste water composition changes little so that the bacteria can achieve optimum adaptation to this waste water. The organic ingredients of the washing media are decomposed by introducing air. The advantage of the procedure is not only the significant reduction of the amount of waste material, but also enhanced efficiency of the cleaning process. The decontamination factor in Gundremmingen improved from a factor of 5 to a factor ...

1999-03-01

86

National Ignition Facility Incorporates P2/E2 in Aqueous Parts Cleaning of Optics Hardware  

Energy Technology Data Exchange (ETDEWEB)

When completed, Lawrence Livermore National Laboratory's (LLNL) National Ignition Facility (NIF) will be the world's largest laser with experimental capabilities applicable to stockpile stewardship, energy research, science and astrophysics. As construction of the conventional facilities nears completion, operations supporting the installation of specialized laser equipment have come online. Playing a critical role in the precision cleaning of mechanical parts from the NIF beamline are three pieces of aqueous cleaning equipment. Housed in the Optics Assembly Building (OAB), adjacent to NIF's laser bay, are the large mechanical parts gross cleaner (LMPGC), the large mechanical parts precision cleaner (LMPPC), and the small mechanical parts gross and precision cleaner (SMPGPC). These aqueous units, designed and built by Sonic Systems, Inc., of Newtown, Pennsylvania, not only accommodate parts that vary greatly in size, weight, geometry, surface finish and ...

2001-07-27

87

Small heat shock protein 20 (HspB6) in cardiac hypertrophy and failure  

British Library Electronic Table of Contents (United Kingdom)

Hsp20, referred to as HspB6, is constitutively expressed in various tissues. Specifically, HspB6 is most highly expressed in different types of muscle including vascular, airway, colonic, bladder, and uterine smooth muscle; cardiac muscle; and skeletal muscle. It can be phosphorylated at Ser-16 by both cAMP- and cGMP-dependent protein kinases (PKA/PKG). Recently, Hsp20 and its phosphorylation have been implicated in multiple physiological and pathophysiological processes including smooth muscle relaxation, platelet aggregation, exercise training, myocardial infarction, atherosclerosis, insulin resistance and Alzheimer's disease. In the heart, key advances have been made in elucidating the significance of Hsp20 in contractile function and cardioprotection over the last decade. This mini-rev...

2011-01-01

88

Effective Parameters on the Stress-Strain Curve of Nylon 66/Clay Nanocomposite Using FEM  

British Library Electronic Table of Contents (United Kingdom)

Abstract:- In recent years, the study of polymer/clay nanocomposites has attracted major research and commercial interests due to their superior mechanical and thermal properties to those of the neat polymers. Numerical modelling is an advantageous approach to understand the material behaviour. In this work a symmetric two dimensional finite element model is developed to simulate the fully exfoliated Polymer/Clay nanocomposite behaviour and evaluate its- before stress stress-strain curve. The Nylon 66/Clay in this study has a nonlinear elastic behaviour. The influence of volume fraction and aspect ratio of clay platelet (defined as the ratio of the particle length to the particle thickness) on the tensile behaviour of exfoliated Nylon 66/clay nanocomposite is investigated with the aid of n...

2011-01-01

89

Concurrent immune thrombocytopenic purpura and Guillain-Barre syndrome in a patient with Hashimotos thyroiditis  

British Library Electronic Table of Contents (United Kingdom)

Immune thrombocytopenic purpura (ITP), Guillain-Barre syndrome (GBS), and Hashimotos thyroiditis (HT) are autoimmune disorders caused by impaired self-tolerance mechanisms triggered by interaction between genetic and environmental factors. ITP is an immune-mediated destruction of platelets resulting in mucocutaneous bleeding, GBS is an ascending motor paralysis caused by an inflammatory demyelination of peripheral nerves, and HT is characterized by autoimmune-mediated destruction of the thyroid gland. The concurrent development of ITP and GBS has only rarely been reported in the literature, and GBS itself rarely occurs with other autoimmune disorders. We present a 21 year-old patient with known Hashimotos hypothyroidism that simultaneously developed GBS and ITP after an upper respiratory t...

2007-01-01

90

Apheresis affects bone and mineral metabolism  

British Library Electronic Table of Contents (United Kingdom)

Background: Apheresis is a procedure to selectively obtain blood components. For the collection process citrate is routinely used. It inhibits coagulation by binding to ionized calcium and leads to metabolic alkalosis. Objective: Whether regular apheresis affects bone and mineral metabolism is unknown. The intention of this study was to investigate 1) the acute effects of apheresis on acid-base balance, bone and mineral metabolism and 2) to compare bone mineral density (BMD) at the lumbar spine and hip of donors to matched control subjects. Design: In this open, observational, single-center, cross-sectional study we enrolled 102 regular plasma and thrombocyte donors to pursue objective 1) and compared those to 102 matched controls (CTR) for objective 2). Results: Platelet donation led to s...

2010-01-01

91

Human endogenous retroviruses: transposable elements with potential ?  

UK PubMed Central (United Kingdom)

Human endogenous retroviruses (HERVs) are a significant component of a wider family of retroelements that constitute part of the human genome. These viruses, perhaps representative of previous exogenous...Full Text Available

2004-10-01

92

Human Factors in Network Security  

Science.gov (United States)

... TITLE (Indlude Security Classifkcation) Human Factors in Network Security 12. ... FIELD GROUP SUBGROUP Human Factors, Network, Security 19. ...

1991-03-21

93

Radiation therapy for Kasabach-Merritt syndrome. Analysis of unfavorable factors in 5 children  

Energy Technology Data Exchange (ETDEWEB)

During the past 10 years, five infants with Kasabach-Merritt syndrome (K-M) receiving radiation therapy were reported. We investigated whether radiation therapy for K-M was useful and what the unfavorable factors of K-M were. During the past 10 years, we have treated five infants with K-M. The syndrome occurred at ages ranging from birth to 4 months. The incidence of female to male ratio was 3:2. Among 5 cases, the site of hemangioma was as follows; shoulder, anterior chest wall, lower abdominal wall, face and neck and inguinal site. All 5 cases received medication to control the coagulopathy including prednisone and blood transfusion at first. Because the platelet count and the bleeding tendency did not improve in any case, these cases received radiation therapy. Total dose ranged from 5 to 10 Gy and fraction-size ranged from 0.5 to 1.75 Gy. Irradiation session was 2 or 3 times per week. In 5 cases, 4 cases showed cure of bleeding tendency and disappearance of ...

1996-03-01

94

Zoonoses-With Friends Like This, Who Needs Enemies?  

UK PubMed Central (United Kingdom)

Zoonoses are infections that are spread from animals to humans. Most often, humans are “dead-end” hosts, meaning that there is no subsequent human-to-human transmission. If one considers...Full Text Available

2008-01-01

96

Molecular and immunological comparison of human dihydropteridine reductase in liver, cultured fibroblasts and continuous lymphoid cells.  

UK PubMed Central (United Kingdom)

An antiserum was raised in a rabbit against highly purified human liver dihydropteridine reductase (EC 1.6.99.7). Dihydropteridine reductase from human liver, in human cultured fibroblasts and in continuous...Full Text Available

1981-07-01

98

Humanities for medical students? A qualitative study of a medical humanities curriculum in a medical school program  

UK PubMed Central (United Kingdom)

BackgroundToday, there is a trend towards establishing the medical humanities as a component of medical education. However, medical humanities programs that exist within the context...Full Text Available

101

The fate of trace elements at coal-fired power plants  

International Nuclear Information System (INIS)

Within the framework of a Dutch research program on the environmental effects of coal combustion 15 measuring campaigns were carried out in the eighties. All the relevant ingoing and outgoing flows of electric power plants were sampled and the heavy metals composition was determined. An overview is given of these fifteen measuring campaigns. It is concluded that between 99.7% and 99.9% of the fly ash can be separated by electrofilters. The removal of solid elements is higher than 99%, except for those elements, which are enriched in the fly ash, f.e. Cd and Se (>90% removal is possible). Additional separation of the emissions of fly ash and elements in the fly ash takes place in a flue gas desulfurization (FGD) installation. Some elements are emitted as gaseous wastes. After the electrofilter Cl, F and I can be found for almost 100%, Br and Hg for 50% on average, and only small amounts of As and Se in the gaseous phase. In a wet FGD unit these elements can be ...

102

Performance evaluation of corrosion probes in simulated WVNS tank 8D-2 waste: WVNS tank farm process support  

Energy Technology Data Exchange (ETDEWEB)

Five corrosion probes were received from West Valley Nuclear Services for evaluation in simulated tank 8D-2 3rd-stage sludge wash slurry. The same waste slurry simulated was also used in a series of ongoing corrosion studies assessing the effects of in-tank sludge washing on the integrity of tank 8D-2. Two of the corrosion probes were installed in the coupon corrosion test vessels operating at {approximately}150{degrees}F to compare performance of the probes with that observed by coupon tests conducted in the same vessels. Corrosion rate data calculated from electrical resistance measurements of the corrosion probes were evaluated for this study using two slightly different approaches. One approach uses the total length of exposure of the probe to give a ``time-averaged`` value of the corrosion rate. The other approach uses a shorter period of time (relative to the length of the test) in the calculation of corrosion rate, and is referred to as ...

1994-07-01

103

Measurement of mud level interfaces: A tool for optimization of red mud washing at C.V.G. Bauxilum  

Energy Technology Data Exchange (ETDEWEB)

For the expansion to 2.0 MTPY of the CVG Bauxilum alumina plant, the area of clarification and red mud washing was rearranged from four 2-thickener-5-washer trains to two 1-thickener-7-washer trains. As a result of this modification, the specific mud handling capacity of the existing tanks should be increased by almost 3-times. The time allowed for control actions was then significantly reduced, leading to the need of an on-line level detection system, in order to achieve a better and faster control of the operation. With this scope, it was developed and installed a new continuous mud level detector that gives the measurement of both mud and turbid zone levels in the tanks. The development of the new instrument started with an existing instrument for density measurements which was completely re-engineered in order to obtain the maximum readability in the densities founded along the full range of the tank height. Actually 28 tanks are equipped with these instruments ...

1996-10-01

104

Measurement of local cerebral blood flow by computerized tomography with inhalation of stable xenon and curve-fitting method  

Energy Technology Data Exchange (ETDEWEB)

Non-invasive methods are described for estimating local cerebal blood flows (LCBF) and local partition coefficients (Llambda) during inhalation of 30 % stable xenon gas (Xe) in oxygen during CT scanning. After the denitrogenation with pure oxygen breathing, 30 % Xe is inhaled for four minutes to minimize subanesthetic effects with a rubber facemask and the delivery system of Xe. Local time-..delta.. Hounsfield units curve during the Xe wash-in and wash-out phase is utilized in order to calculate Llambda and LCBF using a least squares curve fitting analysis. Calculated Llambda and LCBF with the new method manifested reasonable distribution between the grey and white matters, and reproducibility was excellent in our study. Several case studies of patients with cerebral infarction are presented to demonstrate the characterization of Llambda and LCBF patterns in various tissues and theoretical grounds underlying the new method of curve fitting ...

1988-07-01

105

Measurement of local cerebral blood flow by computerized tomography with inhalation of stable xenon and curve-fitting method  

International Nuclear Information System (INIS)

Non-invasive methods are described for estimating local cerebal blood flows (LCBF) and local partition coefficients (L#lambda#) during inhalation of 30 % stable xenon gas (Xe) in oxygen during CT scanning. After the denitrogenation with pure oxygen breathing, 30 % Xe is inhaled for four minutes to minimize subanesthetic effects with a rubber facemask and the delivery system of Xe. Local time-#DELTA# Hounsfield units curve during the Xe wash-in and wash-out phase is utilized in order to calculate L#lambda# and LCBF using a least squares curve fitting analysis. Calculated L#lambda# and LCBF with the new method manifested reasonable distribution between the grey and white matters, and reproducibility was excellent in our study. Several case studies of patients with cerebral infarction are presented to demonstrate the characterization of L#lambda# and LCBF patterns in various tissues and theoretical grounds underlying the new method of curve ...

106

Decontamination factor of the commercial detergents for the skin (part 3)  

Energy Technology Data Exchange (ETDEWEB)

The commercial detergents, which are cleansing cream, shampoo, neutral detergent, etc., were examined in order to select the body cleaners that are substitutes for the titanium dioxide paste. JNC entrusted Japan Environment Research Corporation Limited with these examinations since 1997. In 1997 and 1998, the commercial detergents were examined for Ce-144, Cs-137 and Ru-106. In 1999, 22 detergents were examined for Co-60 from the result of the past examinations. In this examination, the radioactive solution of Co-60 was dropped on the pig-skin samples. These samples were washed with each detergent after 5 minutes and 40 minutes. The decontamination factors of detergents were estimated by the radioactive ratio of the samples before and after washing. As a result of this examination, the decontamination factors for Co-60 was the same as the decontamination factors for Ce-144 and Cs-137, and 11 detergents were nominated as the cleaner that have ...

2000-08-01

107

Decontamination factor of the commercial detergents for the skin (part 3)  

International Nuclear Information System (INIS)

The commercial detergents, which are cleansing cream, shampoo, neutral detergent, etc., were examined in order to select the body cleaners that are substitutes for the titanium dioxide paste. JNC entrusted Japan Environment Research Corporation Limited with these examinations since 1997. In 1997 and 1998, the commercial detergents were examined for Ce-144, Cs-137 and Ru-106. In 1999, 22 detergents were examined for Co-60 from the result of the past examinations. In this examination, the radioactive solution of Co-60 was dropped on the pig-skin samples. These samples were washed with each detergent after 5 minutes and 40 minutes. The decontamination factors of detergents were estimated by the radioactive ratio of the samples before and after washing. As a result of this examination, the decontamination factors for Co-60 was the same as the decontamination factors for Ce-144 and Cs-137, and 11 detergents were nominated as the cleaner that have ...

108

Breakdowns of high-voltage transmission lines due to sea-salt deposits on insulators  

Energy Technology Data Exchange (ETDEWEB)

Until 1990, in Tuscany, salt pollution of anti-salt insulators installed on high-tension transmission lines had led to rare breakdowns. On the contrary, in the last months of 1990, in most of Tuscany, following a strong libeccio wind coming from the Tyrrhenian Sea, and due to a long period of drought, salt deposits accumulated on the insulators of the high-voltage transmission lines (380 kV, 220 kV and 132 kV). This phenomenon not only took place in the coastal areas near Livorno, Pisa and Grosseto, but also in areas far away from the sea such as Florence, Prato, Arezzo and Siena. Following this, several high-tension lines, and whole sections of 380 kV electric stations went out of order, damaging the stations' equipment, insulators on the lines, and in particular porcelain insulators. The maintenance operations that were immediately undertaken consisted in washing operations, first focussed on stations, and then on lines. Several hundred men and some ...

1992-03-01

109

Breakdowns of high-voltage transmission lines due to sea-salt deposits on insulators  

International Nuclear Information System (INIS)

Until 1990, in Tuscany, salt pollution of anti-salt insulators installed on high-tension transmission lines had led to rare breakdowns. On the contrary, in the last months of 1990, in most of Tuscany, following a strong libeccio wind coming from the Tyrrhenian Sea, and due to a long period of drought, salt deposits accumulated on the insulators of the high-voltage transmission lines (380 kV, 220 kV and 132 kV). This phenomenon not only took place in the coastal areas near Livorno, Pisa and Grosseto, but also in areas far away from the sea such as Florence, Prato, Arezzo and Siena. Following this, several high-tension lines, and whole sections of 380 kV electric stations went out of order, damaging the stations' equipment, insulators on the lines, and in particular porcelain insulators. The maintenance operations that were immediately undertaken consisted in washing operations, first focussed on stations, and then on lines. Several hundred men and some helicopters ...

1992-01-01

110

Actinide, strontium, and cesium removal from Hanford radioactive tank sludge  

International Nuclear Information System (INIS)

A pretreatment flowsheet was tested for separating key radionuclide components from the sludge stored in one of the high level waste tanks (B-110) at the Hanford Site; this sludge resulted primarily from the bismuth phosphate process, which was one of the three major plutonium separation processes used at Handford. This test involved (1) washing with water, (2) caustic leaching, (3) acid dissolution, (4) separation of transuranic elements (TRUs) by extraction with octyl(phenyl)-N,N-diisobutylcarbamoylmethylphosphine oxide(CMPO), (5) separation of Sr by extraction with di-t-butylcyclohexano-18-crown-6, (6) separation of Cs from the acid-dissolved sludge solution by treatment with ammonium molybdophosphate (AMP), and (7) separation of Cs from the sludge wash and caustic leach solutions by ion exchange using a phenol-formaldehyde resin (CS-100). The results of the radionuclide separation steps indicated that the proposed flowsheet is a viable ...

111

Use and disposal of large home electronic appliances in Vietnam  

British Library Electronic Table of Contents (United Kingdom)

In this study, e-waste flows of five large home appliances (color televisions, refrigerators, washing machines, personal computers, and air conditioners) in Vietnam are investigated. A social survey was performed to investigate the situation on using appliances in households as well as on the disposal of appliances by the first users. Future quantities of e-waste were estimated using a model that combines use of the Weibull distribution, the logistic function, and the population balance model. It was forecast that about 3.86 million appliances, or 114 000 tons, will be discarded in 2010, and about 17.2 million appliances, or 567 000 tons, in 2025, showing a rapid increase of e-waste in the near future.

2009-01-01

112

Uptake of atmospheric tritium by market foods  

Energy Technology Data Exchange (ETDEWEB)

In this paper uptake of tritium by market foods from tritiated water vapor in the air is investigated using cereals and beans purchased in Deep River, Canada. The concentrations of tissue free water tritium (TFWT) and organically bound tritium (OBT) range from 12 to 79% and from 10 to 38% respectively, of that estimated for atmospheric water vapor of the sampling month. The specific activity ratios of OBT to TFWT were constant for cereals, but variable for beans. The elevated OBT was shown to be the result of isotopic exchange of labile hydrogen by the fact that washing the foods with tritium free-water reduced their tritium contents to levels characteristic of their production sites.

1992-03-01

113

The production of carrier-free lead-203  

International Nuclear Information System (INIS)

The chemical separation of carrier-free "2"0"3Pb following deuterium bombardment of a "2"0"3Tl target is described. Coprecipitation from strontium sulphate was used to separate the "2"0"3Pb from a solution of the thallium target in sulphuric acid. The SrSO_4 precipitate was filtered, washed and dissolved in hydrochloric acid, from which "2"0"3Pb was again separated by precipitation on sodium chloride from a strongly acid solution. Advantages of the system are discussed and optimum conditions given. (U.K.).

114

Simple method for the high-temperature isolation of /sup 111/In from silver  

Energy Technology Data Exchange (ETDEWEB)

A method is proposed for the quantitative high-temperature isolation of /sup 111/In from silver irradiated by ..cap alpha..-particles into a gas phase containing a mixture of HCl and H/sub 2/O with a total pressure of about 3 Pa for these gases. It is shown that the indium evolved into the gas phase probably occurs in the form of at least three compounds, viz.., the trichloride, monochloride, and oxychloride, which have adsorption temperatures on quartz of around 385, 475, and 655 K, respectively. All these compounds are readily washed from the surface of quartz apparatus by a weak (0.05 M) solution of hydrochloric acid.

1987-07-01

115

Production of carrier-free lead-203  

Energy Technology Data Exchange (ETDEWEB)

The chemical separation of carrier-free /sup 203/Pb following deuterium bombardment of a /sup 203/Tl target is described. Coprecipitation from strontium sulphate was used to separate the /sup 203/Pb from a solution of the thallium target in sulphuric acid. The SrSO/sub 4/ precipitate was filtered, washed and dissolved in hydrochloric acid, from which /sup 203/Pb was again separated by precipitation on sodium chloride from a strongly acid solution. Advantages of the system are discussed and optimum conditions given.

1982-07-01

116

Flue gas desulfurization. Rauchgasentschwefelung  

Energy Technology Data Exchange (ETDEWEB)

Low-dust flue gases can be washed efficiently of SO/sub 2/, and the flue gas heat can be utilized. The residual heat fraction still required by the process is characterized by a temperature of 15/sup 0/K above the temperature of the purified flue gas. Marketable crystalline ammonium sulfate is produced. The high efficiency and low heat consumption are achieved by combining all process stages in a single, fully integrated cycle process free of heat and materials losses. The process is characterized by high efficiency, low investment and operating costs, recovery of thermal energy, and production of an ammonium sulfate fertilizer.

1983-04-07

117

Dispersion study of cesium-137 radionuclide in ocean; Estudo da dispersao do radionuclideo cesio-137 nos oceanos  

Energy Technology Data Exchange (ETDEWEB)

A study for Cs-137 radionuclide dispersion in the marine environment through of compartmental model (Box Model) is presented. The model simulates the surface water contamination caused by direct atmospheric deposition, surface wash off, desorption from sediments and transfer with the ground water of accidentally released radionuclides. For this study the model was applied to the North Sea, near to Sellafield, based on the transfer coefficients obtain at the literature. The results obtained are in good agreement with the literature, being that the model developed can be applied in to the brazilian coastal regions. (author). 7 refs, 7 figs.

1995-12-31

118

Installation of a stoker-coal preparation plant in Krakow, Poland. Quarterly technical progress report No. 3, November--December 1994  

Energy Technology Data Exchange (ETDEWEB)

This report describes the progress made during this reporting period of a two year project to demonstrate that the air pollution from a traveling grate stoker being used to heat water at a central heating plant in Krakow, Poland can be reduced significantly by (1) substituting the unwashed, unsized coal currently being used with a mechanically cleaned, double-sized stoker fuel and by (2) optimizing the operating parameters of the stoker. It is anticipated that these improvements will prove to be cost effective and hence be adopted by the other central heating plants in Krakow and indeed, throughout Eastern European cities where coal continues to be the primary source of fuel. EFH Coal Company has formed a partnership with two Polish institutions -- MPEC, a central heating company in Krakow, and Naftokrak-Naftobudowa, preparation plant designers and fabricators, for the execution of this effort. The washability data from a 20mm x 0.5mm size fraction of raw coal from the Nikwa Modrejow ...

1996-01-01

119

Full-scale soil washing/TERRAMET{reg_sign} soil leaching  

Energy Technology Data Exchange (ETDEWEB)

COGNIS TERRAMET{reg_sign} soil leaching and Bescorp soil washing systems have been successfully combined to remediate an ammunition test burn area at the Twin Cities Army Ammunition Plant (TCAAP), New Brighton, MN. This cleanup is the first in the country to combine these two technologies, and this approach offers a permanent remedial solution. In Fall 1993, 1,600 tons of soil were remediated with an additional 10,000+ tons treated in 1994. The cleaned soil remained on-site, and the heavy metal contaminants were removed, recovered, and recycled. Eight heavy metals were removed from the contaminated soil achieving the very stringent cleanup criteria of <175 ppm for residual lead and achieving background concentrations for seven other heavy metals (antimony, cadmium, chromium, copper, mercury, nickel, and silver). In addition, both live and spent ordnance had to be removed in the soil treatment plant to meet the cleanup criteria. No hazardous waste requiring ...

1995-09-01

120

In vitro corrosion, cytotoxicity and hemocompatibility of bulk nanocrystalline pure iron  

International Nuclear Information System (INIS)

Bulk nanocrystalline pure iron rods were fabricated by the equal channel angular pressure (ECAP) technique up to eight passes. The microstructure and grain size distribution, natural immersion and electrochemical corrosion in simulated body fluid, cellular responses and hemocompatibility were investigated in this study. The results indicate that nanocrystalline pure iron after severe plastic deformation (SPD) would sustain durable span duration and exhibit much stronger corrosion resistance than that of the microcrystalline pure iron. The interaction of different cell lines reveals that the nanocrystalline pure iron stimulates better proliferation of fibroblast cells and preferable promotion of endothelialization, while inhibits effectively the viability of vascular smooth muscle cells (VSMCs). The burst of red cells and adhesion of the platelets were also substantially suppressed on contact with the nanocrystalline pure iron in blood circulation. A clear ...

2010-12-01

121

Effect of intermetallic growth rate on spontaneous whisker growth from a tin coating on copper  

British Library Electronic Table of Contents (United Kingdom)

Intermetallic compound (IMC) growth at the interface between a Sn coating and a Cu substrate with or without a Ni underlayer and its related stress state was evaluated by real-time measurements using the flexure beam method. For the Sn coating without a Ni underlayer, pyramid-shaped IMC grains of Cu6Sn5 grew along the grain boundaries of Sn from the Cu substrate, especially at the triple grain boundary junctions and the IMC grains rapidly increased their volume during the initial 3?days, During this time, the IMC growth rate was 2.3??m3/day and the compressive stress in the Sn coating rapidly developed and became saturated at about ?11?MPa. In contrast, platelet IMC grains of Ni3Sn4 formed at the surface of the Ni underlayer and the IMCs grew at a rate of 1.0??m3/day for the Sn/Ni coating....

2011-01-01

122

Depth profiling using C{sub 60} {sup +} SIMS-Deposition and topography development during bombardment of silicon  

Energy Technology Data Exchange (ETDEWEB)

A C{sub 60} {sup +} primary ion source has been coupled to an ion microscope secondary ion mass spectrometry (SIMS) instrument to examine sputtering of silicon with an emphasis on possible application of C{sub 60} {sup +} depth profiling for high depth resolution SIMS analysis of silicon semiconductor materials. Unexpectedly, C{sub 60} {sup +} SIMS depth profiling of silicon was found to be complicated by the deposition of an amorphous carbon layer which buries the silicon substrate. Sputtering of the silicon was observed only at the highest accessible beam energies (14.5 keV impact) or by using oxygen backfilling. C{sub 60} {sup +} SIMS depth profiling of As delta-doped test samples at 14.5 keV demonstrated a substantial (factor of 5) degradation in depth resolution compared to Cs{sup +} SIMS depth profiling. This degradation is thought to result from the formation of an unusual platelet-like grain structure on the SIMS crater bottoms. Other unusual topographical ...

2006-07-30

123

Characterization of the xanthine-binding site on R/sub a/ and R/sub i/ subtypes of the adenosine receptor  

Energy Technology Data Exchange (ETDEWEB)

Methylxanthines and their derivatives are antagonists at cell surface adenosine receptors. They report here a systematic study of xanthine structure-activity relationships which compares potency at two adenosine receptor subtypes, R/sub a/ and R/sub i/. Adenylate cyclase stimulation (R/sub a/ in platelet membranes) and inhibition (R/sub i/ in adipocyte membranes) were used as models of receptor activation. K/sub i/ values were obtained by Schild analysis. The orders of potency of the xanthines to attenuate the effects of adenosine analogues were similar to those previously reported. Earlier work utilizing radioligand binding (R/sub i/ and (/sup 3/H) cAMP formation (R/sub a/) claimed that IIX and PACPX are at least 10 and 400 fold, respectively, more potent at R/sub i/ than at R/sub a/. However, in their assays which utilize modulation of receptor-coupled adenylate cyclase, the xanthines show little specificity for either adenosine receptor subtype.

1986-05-01

124

Angiogenic cytokines and growth factors in systemic sclerosis.  

Science.gov (United States)

Systemic sclerosis is an autoimmune connective tissue disorder characterized by a widespread microangiopathy, autoimmunity and fibrosis of the skin and of various internal organs. Microangiopathy is characterized by a reduced capillary density and an irregular chaotic architecture that lead to chronic tissue hypoxia. Despite the hypoxic conditions, there is no evidence for a sufficient compensative angiogenesis in SSc. Furthermore, vasculogenesis is also impaired. An imbalance between angiogenic and angiostatic factors might explain the pathogenetic mechanisms of SSc vasculopathy. As far as angiogenic factors are concerned, within the most important are vascular endothelial growth factor (VEGF) and its receptors, platelet derived growth factor (PDGF), transforming growth factor beta (TGF-?), fibroblast growth factor -2 (FGF-2), angiopoietin 1 (Ang-1), stromal cell-derived factor 1 (SDF-1/CXCL12), endothelin-1 (ET-1), monocyte chemoattractant protein -1 (MCP-1), ...

2011-04-28

125

An availability of brain magnetic resonance imaging (MRI) in the early diagnosis of latent hepatic encephalopathy  

Energy Technology Data Exchange (ETDEWEB)

Brain MRI was carried out in patients with chronic liver diseases. No abnormal findings were recognized in patients with chronic viral hepatitis, while 59.2% of cirrhotics showed a symmetrically strong signal in basal ganglia on T1 weighted image in MRI. This finding significantly related with lowered Fischer`s ratio of serum amino acid, increased levels of serum phenylalanine, tyrosine and hyaluronic acid, prolonged prothrombin time and decreased platelet counts in the peripheral blood. Overt hepatic encephalopathy was observed in 6 of 34 patients with the strong signal in MRI during follow-up period, while none of patients without that finding developed hepatic encephalopathy. These results have indicated that the strong signal in basal ganglia on MRI appears in cirrhotic patients with severe liver dysfunction, and it is an useful index in the early diagnosis of latent hepatic encephalopathy. An improvement of this MRI finding was not observed by long-term oral ...

1996-03-01

126

Targeting Prostate Cancer Cells In Vivo Using a Rapidly Internalizing Novel Human Single-Chain Antibody Fragment  

UK PubMed Central (United Kingdom)

Human antibodies targeting prostate cancer cell surface epitopes may be useful for imaging and therapy. The objective of this study was to evaluate the tumor targeting of an internalizing human...Full Text Available

2010-03-01

127

Suppression by IgA of IgG-mediated phagocytosis by human polymorphonuclear leucocytes  

UK PubMed Central (United Kingdom)

IgA from normal human serum, a myeloma IgA and human colostral IgA were found to inhibit the IgG-dependent phagocytosis of Candida albicans (CA) blastospores by polymorphonuclear leucocytes...Full Text Available

1978-12-01

128

Rhythmic Dynamics and Synchronization via Dimensionality Reduction: Application to Human Gait  

UK PubMed Central (United Kingdom)

Reliable characterization of locomotor dynamics of human walking is vital to understanding the neuromuscular control of human locomotion and disease diagnosis. However, the inherent oscillation and...Full Text Available

2010-12-01

129

Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry assay for organophosphorus toxicants bound to human albumin at Tyr411  

UK PubMed Central (United Kingdom)

Our goal was to determine whether chlorpyrifos oxon, dichlorvos, diisopropylfluorophosphate (DFP), and sarin covalently bind to human albumin. Human albumin or plasma was treated with organophosphorus...Full Text Available

2007-02-15

130

Human variability and susceptibility to trichloroethylene.  

UK PubMed Central (United Kingdom)

Although humans vary in their response to chemicals, comprehensive measures of susceptibility have generally not been incorporated into human risk assessment. The U.S. EPA dose-response-based risk assessments...Full Text Available

2000-05-01

131

Human placental transport of cimetidine.  

UK PubMed Central (United Kingdom)

This study addresses the mechanism of transport of the H2-receptor antagonist, cimetidine, by the human placenta. A 4-h recycling perfusion of a single placental cotyledon of normal, term, human placenta...Full Text Available

1987-11-01

132

Genome-wide detection and characterization of positive selection in human populations  

UK PubMed Central (United Kingdom)

With the advent of dense maps of human genetic variation, it is now possible to detect positive natural selection across the human genome. Here we report an analysis of over 3 million polymorphisms...Full Text Available

2007-10-18

133

Establishment of an Immunoglobulin M Antibody-Forming Cell Response Model for Characterizing Immunotoxicity in Primary Human B Cells  

UK PubMed Central (United Kingdom)

Rodent models have been extensively utilized to identify putative human immunotoxicants; however, even when immunotoxicity is established, uncertainty remains whether the effects are predictive of human...Full Text Available

2009-12-01

134

Drug-binding properties of human alpha-foetoprotein.  

UK PubMed Central (United Kingdom)

The drug-binding properties of human alpha-foetoprotein (alpha FP) were investigated by a fluorescence-spectral method. Human alpha FP was shown to bind to albumin's site I marker (warfarin, phenylbutazone),...Full Text Available

1985-10-01

135

A haplotype map of the human genome  

UK PubMed Central (United Kingdom)

Inherited genetic variation has a critical but as yet largely uncharacterized role in human disease. Here we report a public database of common variation in the human genome: more than one million...Full Text Available

2005-10-27

136

Uptake and Retention of Adenine Moiety by Stored Human ...  

Science.gov (United States)

... Accession Number : AD0749455. Title : Uptake and Retention of Adenine Moiety by Stored Human Red Blood Cells. Descriptive Note : Interim rept.,. ...

1972-06-30

138

Structure design of human factor data management system for Daya Bay NPP  

International Nuclear Information System (INIS)

Collection, analysis and quantification of human factor data are important compositions of human reliability analysis (HRA) and probabilistic risk assessment (PRA). Various human factor databases have been set up, but there are comparatively little human factor data management systems which can be uses for collection, classification, analysis, calculation and predication of the human factor data. Therefore, the human factor data management system for Daya Bay NPP is developed, with the following three modules and four databases: original data module, computing module, introduced data module, and basic database, other data source of the plant, external database and introduced database. The foundational problems about human factor data and the systemic structure and function are described. The data structure in the database is also discussed, ...

2000-04-01

139

Quantifying Risk Factors for Human Brucellosis in Rural Northern Tanzania  

UK PubMed Central (United Kingdom)

BackgroundBrucellosis is a zoonosis of veterinary, public health and economic significance in most developing countries. Human brucellosis is a severely debilitating disease that...Full Text Available

140

Priorities for human nutrition research using stable isotopes in India  

International Nuclear Information System (INIS)

In this paper, an attempt is made to outline the priority areas for research in human nutrition in India that could be tackled by appropriate application of stable isotope technology. 10 refs.

1989-06-06

141

Navy Requirements for Controlling Multiple Off-Board Robots ...  

Science.gov (United States)

... less humans have to do to operate a robot. ... Robots can help human operators with the increase ... important mission outlined by the UUV master plan. ...

2007-06-01

142

Measurement methods for human exposure analysis.  

UK PubMed Central (United Kingdom)

The general methods used to complete measurements of human exposures are identified and illustrations are provided for the cases of indirect and direct methods used for exposure analysis. The application...Full Text Available

1995-04-01

143

Imaging oxygenation of human tumours  

UK PubMed Central (United Kingdom)

Tumour hypoxia represents a significant challenge to the curability of human tumours leading to treatment resistance and enhanced tumour progression. Tumour hypoxia can be detected by non-invasive and...Full Text Available

2007-04-01

144

Human-modified ecosystems and future evolution  

UK PubMed Central (United Kingdom)

Our global impact is finally receiving the scientific attention it deserves. The outcome will largely determine the future course of evolution. Human-modified ecosystems are shaped by our activities...Full Text Available

2001-05-08

145

Human factors  

Energy Technology Data Exchange (ETDEWEB)

This is a presentation on Human Factors in reactor operations. It discusses issues that deal with power plant operations, training and design, operational effectiveness and safety, supporting people to achieve effective and error free performance.

2002-07-01

146

Do Perfluoroalkyl Compounds Impair Human Semen Quality?  

UK PubMed Central (United Kingdom)

BackgroundPerfluoroalkyl acids (PFAAs) are found globally in wildlife and humans and are suspected to act as endocrine disruptors. There are no previous reports of PFAA levels in...Full Text Available

2009-06-01

147

A Transposon and Transposase System for Human Application  

UK PubMed Central (United Kingdom)

The stable introduction of therapeutic transgenes into human cells can be accomplished using viral and nonviral approaches. Transduction with clinical-grade recombinant viruses offers the potential...Full Text Available

2010-04-01

148

A Four-Dimensional Probabilistic Atlas of the Human Brain  

UK PubMed Central (United Kingdom)

The authors describe the development of a four-dimensional atlas and reference system that includes both macroscopic and microscopic information on structure and function of the human brain in persons...Full Text Available

2001-09-01

149

A Detailed Investigation on Human-Related Unplanned Reactor Trip Events in Korea  

International Nuclear Information System (INIS)

Human errors have been reported as one of the most significant causes of major events in nuclear power plants (NPPs). For example, Kim and Park found that about 23% of the major events that occurred at NPPs in Republic of Korea from 1986 to 2006 were caused by human errors. For this reason, a detailed analysis on human errors is an important task for increasing the safety of NPPs. Kim and Choi?2 analyzed 100 human-related unplanned reactor trip events in the Republic of Korea from 1986 to 2006 to consider the type of human errors based on the simple path model for human-induced unplanned reactor trips developed by Kim and Park. In this paper, we will investigate and perform a detailed analysis of the data to identify human-related unplanned reactor trip trends

2010-10-01

150

A Comparison of Some Demand Subject Searches: Machine vs. Human  

UK PubMed Central (United Kingdom)

A comparison of the results of machine and human information retrieval using MEDLARS and the printed Index Medicus indicates that at present neither method is entirely satisfactory...Full Text Available

1967-10-01

151

Waste treatment process for removal of contaminants from aqueous, mixed-waste solutions using sequential chemical treatment and crossflow microfiltration, followed by dewatering  

Energy Technology Data Exchange (ETDEWEB)

It is an object of the claimed invention to combine chemical treatment with microfiltration process to treat groundwater, leachate from contaminated soil washing, surface and run-off waters contaminated with toxic metals, radionuclides and trace amounts of organics from variety of sources. The process can also be used to treat effluents from industrial processes such as discharges associated with smelting, mining and refining operations. Influent contaminants amenable to treatment are from a few mg/L to hundreds of mg/L. By selecting appropriate precipitation, ion exchange and adsorption agents and conditions, efficiencies greater than 99.9 percent can be achieved for removal of contaminants. The filtered water for discharge can be targeted with either an order of magnitude greater or lower than contaminant levels for drinking water.

1992-12-31

152

The preparation and properties of some activated carbons modified by treatment with phosgene or chlorine  

Energy Technology Data Exchange (ETDEWEB)

Treatment of coal or coconut shell activated carbons with either phosgene or chlorine at 180{degree}C followed by washing with methanol or water results in chlorinated carbons with very similar pore structures to their precursors. Water adsorption experiments show that the modified materials are relatively hydrophobic, presumably as a result of replacement of oxygen-containing surface groups by chlorine. Adsorption of the model hydrophobic vapour chloropicrin from humid air is usually better for the modified carbons which, unlike the controls, do not appear to be subject to degradation in performance on ageing in a humid atmosphere. The stability of the modified carbons is probably a consequence of the chlorination of those sites on the control carbons that are prone to ready oxidation or hydroxylation. 1 tab., 2 figs., 17 refs.

1992-01-01

153

The isolation of "1"3"9Ce after production by a proton-induced nuclear reaction on praseodymium  

International Nuclear Information System (INIS)

A method, based on anion exchange chromatography, is presented for the isolation of "1"3"9Ce after production by a proton-induced nuclear reaction on a thick praseodymium target. After bombardment the target is dissolved in nitric acid and "1"3"9Ce oxidised to the Ce(IV) oxidation state with bromic acid. "1"3"9Ce is then separated form the praseodymium by anion exchange chromatography on a Ag MP-1 resin column in a nitric acid - bromic acid mixture. "1"3"9Ce is sorbed onto the resin column and praseodymium eluted with the acid mixture. The bromic acid is washed out of the column with nitric acid and "1"3"9Ce finally eluted with dilute nitric acid containing sulphur dioxide.

2001-02-17

154

The effects of chemicals in the presence of cellophane on X-ray-induced point mutation and gene conversion in Aspergillus midulans  

International Nuclear Information System (INIS)

The presence of washed or unwashed cellophane alone or together with a bleomycin, mitomycin C or hydrochlorothiazide, ('Esidrex') showed no appreciable effect on survival of either unirradiated or irradiated conidia. Irradiation for a period of 20min reduced the survival of conidia to 20%. The growth of irradiated conidia in the presence of bleomycin, mitomycin C or Esidrex is associated with a 2- to 3-fold increase in the frequency of gene convertants, but was not accompanied by an increase in point mutants. When conidia were grown on cellophane but otherwise treated as before the frequency of gene convertants was increased 8-fold, but induction of point mutants was negligible. This effect was the same for irradiated and unirradiated conidia. The environment created by the cellophane in contract with the medium appears to affect the action of each of the three compounds synergistically. (author).

155

Synthesis of novel tellurium containing analogues of choline and acetylcholine and their quantitation by pyrolysis-gas chromatography-mass spectrometry.  

Science.gov (United States)

Methods for the synthesis and quantitation of the novel choline analogues, telluronium choline and acetyltelluronium choline, are described. An assay procedure utilizing pyrolysis-gas chromatography-mass spectrometry (Py-GC-MS) with cold trapping was developed with [2H4]telluronium choline and [2H4]acetyltelluronium choline as internal standards. The telluronium compounds were ion-pair extracted from tissue with dipicrylamine, washed with 2-butanone, and pyrolyzed prior to GC-MS analysis. The compounds were monitored using selected ion monitoring at m/z 232 and m/z 190 for acetyltelluronium and telluronium choline, respectively, and at m/z 236 and m/z 194 for the analogous deuterated internal standards. The assay was linear over a range of 20 pmol-20 nmol of compound taken through the assay. PMID:8130881

1993-12-31

156

Sterilization of male stray dogs with a single intratesticular injection of calcium chloride: a dose-dependent study  

British Library Electronic Table of Contents (United Kingdom)

ObjectiveTo study a method of chemical sterilization and its efficacy in adult male stray dogs.MethodsSterilization was performed 45 days after a single bilateral intratesticular injection of calcium chloride (CaCl2) at the doses of 5, 10, 15 or 20 mg per testis per kg body weight.ResultsHistomorphological measures of testes showed total necrosis of testicular tissue at 45 days after an injection of either 10 or 15 or 20 mg CaCl2 along with fibrosis and hyalinization in seminiferous tubules and interstitial spaces. Infiltration of leucocytes was also observed with the 10- or 15-mg dose. Disintegration of germ cell arrangement in seminiferous tubules and washing out of germ cells from the tubules were noted with the 5-mg dose. Relative organ weight, epididymal sperm count, plasma and intrat...

2007-01-01

157

Skincare instruction for remission period of acne and utility of proactive management for skincare  

British Library Electronic Table of Contents (United Kingdom)

In recent years, slightly acid formulas for cosmetics which remove follicular infundibulum obstruction of the hair follicle, have been devised. Therefore, few acne patients experience a problem with cosmetics use. On the other hand, cosmetics use differs from person to person. Thus, an investigation of actual conditions of cosmetics use was done among acne patients. Compared with healthy people, acne patients used more facial wash products more. It has been understood that treatment and skincare instruction are important for the improvement and prevention of acne. We examined skin physiology function and patient's QOL by using a skin care product for women for two months with skincare instruction from a dermatologist for 31 female patients this time. As a result, it was able to be confirme...

2010-01-01

158

Removal of uranium from solution using residual brewery yeast: combined biosorption and precipitation  

Energy Technology Data Exchange (ETDEWEB)

Whilst unwashed preparations of biomass from a local brewery had an apparent maximum biosorption capacity for uranium of 360 mg/g (dry weight biomass) washing reduced this maximum to 150 mg/g. Homogenization of both biomass preparations and recovery of cellular debris had no significant effect on the maximum biosorption capacities although at lower equilibrium concentrations of uranium differences in the biosorption capacities were detected. When unwashed biomass was retained by a semi-permeable membrane 40% of uranium used in the experiments precipitated outside that membrane. Therefore a significant proportion of the uranium removed from solution, and previously attributed to biosorption by the yeast biomass, resulted from precipitation brought about by interaction with low molecular weight components loosely associated with the biomass. (Author).

1997-04-01

159

Partnership agreement signed for polymer-additive project  

Energy Technology Data Exchange (ETDEWEB)

A polymer-based additive that permanently reduces hardness in wood electrical transmission poles treated with a chromated copper arsenate (CCA) preservative, has been developed by a team of IREQ researchers. A three-phase project is being funded by Hydro-Quebec to evaluate the additive's effect on full-size hydro poles subjected to actual climatic conditions. The evaluation project is designed to test the CCA and the additive's degree of retention by analyzing the hardness measurements against climbing tests, and the washing resistance of the chromium, copper and arsenate in the CCA/polymer-additive treatment. CCA-treated poles will be used for reference. Accelerated aging tests to characterize the polymer's resistance to UV rays will also be part of the validation program.

1999-12-31

160

Oil-tanker waste-disposal practices: A review  

Energy Technology Data Exchange (ETDEWEB)

In the spring of 1991, the Environmental Protection Agency, Region 10 (EPA), launched an investigation into tanker waste disposal practices for vessels discharging ballast water at the Alyeska Pipeline Services Company's Ballast Water Treatment (BWT) facility and marine terminal in Valdez, Alaska. It had been alleged that the Exxon Shipping Company was transferring 'toxic wastes originating in California' to Valdez. In response, EPA decided to examine all waste streams generated on board and determine what the fate of these wastes were in addition to investigating the Exxon specific charges. An extensive Information Request was generated and sent to the shipping companies that operate vessels transporting Alaska North Slope Crude. Findings included information on cargo and fuel tank washings, cleaning agents, and engine room waste.

1992-01-01

161

Mapping of local cerebral blood flow with stable xenon-enhanced CT and the curve-fitting method of analysis  

Energy Technology Data Exchange (ETDEWEB)

A noninvasive method is described for estimating local cerebral blood flow (LCBF) and local partition coefficients by means of computed tomographic scanning during inhalation of 30% stable xenon gas in oxygen. Time-dependent xenon concentrations in arterial blood and brain tissue during the wash-in and washout phases are used to calculate partition coefficients and LCBF values by means of a least-squares curve-fitting analysis. Control values for partition coefficient and LCBF obtained from control subjects with minor head trauma in the chronic stage were compatible with those in several past reports, and reproducibility was satisfactory. The theoretic grounds underlying this new method of curve-fitting analysis are discussed.

1988-07-01

162

Mapping of local cerebral blood flow with stable xenon-enhanced CT and the curve-fitting method of analysis  

International Nuclear Information System (INIS)

A noninvasive method is described for estimating local cerebral blood flow (LCBF) and local partition coefficients by means of computed tomographic scanning during inhalation of 30% stable xenon gas in oxygen. Time-dependent xenon concentrations in arterial blood and brain tissue during the wash-in and washout phases are used to calculate partition coefficients and LCBF values by means of a least-squares curve-fitting analysis. Control values for partition coefficient and LCBF obtained from control subjects with minor head trauma in the chronic stage were compatible with those in several past reports, and reproducibility was satisfactory. The theoretic grounds underlying this new method of curve-fitting analysis are discussed.

163

Isolation and mapping of a polymorphic DNA sequence (pEFD64. 2) on chromosome 3 (D3S46)  

Energy Technology Data Exchange (ETDEWEB)

A 4.0 kb TaqI fragment of cosmid EFD64 isolated by a HBV-3 oligonucleotide was subcloned into AccI site of pUC18. MspI identifies 5 allelic VNTR polymorphism with bands between 2.6 and 4.6 kb. RsaI, TaqI, EcoRI, BamHI, HindIII and PvuII identify the same VNTR polymorphism. With RsaI, 80% heterozygosity were observed in 80 unrelated Caucasians. This RFLP pEFD64.2 has been assigned to chromosome 3 by linkage analysis with loci (APOD) known to span this chromosome. Co-dominant segregation for the RsaI RFLP was observed in 40 three generation families. RFLPs were observed under the normal hybridization and washing condition.

1988-10-11

164

Inactivation of several strains of Listeria monocytogenes attached to the surface of packaging material by Na-Chlorophyllin-based photosensitization  

British Library Electronic Table of Contents (United Kingdom)

This study was focused on the possibility to inactivate thermosensitive Listeria monocytogenes ATCL3C 7644 and thermoresistant 56 Ly strain by Na-Chlorophyllin (Na-Chl)-based photosensitization in vitro and on the surface of packaging. Comparative analysis of antimicrobial efficiency of photosensitization with conventional surface cleaning was performed. Data indicate that both Listeria strains, after incubation with Na-Chl and following illumination (l=400nm, 20mWcm-2), were inactivated by 7 log in vitro. This treatment cleaned both Listeria strains from packaging surfaces. Comparative analysis indicates that washing with water diminishes pathogens by less than 1 log, 200ppm Na-hypochlorite by 1.7 log, Na-Chl-based photosensitization by 4.5 log. Listeria biofilms were totally removed from...

2010-01-01

165

Extrusion as a thermo-mechanical pre-treatment for lignocellulosic ethanol  

British Library Electronic Table of Contents (United Kingdom)

Two physical pre-treatment methods, particle size reduction by grinding and thermo-mechanical extrusion, were evaluated as alternatives to traditional biomass pretreatments for lignocellulosic ethanol. Commonly available agricultural co-products wheat bran and soybean hull were the model substrates. Extrusion led to higher reducing sugar yields as compared to grinding for wheat bran, but not in the case of soybean hulls. The best combination of extrusion screw speed and maximum barrel temperature were 7 Hz/150 ?C and 3.7 Hz/110 ?C. The use of a solvent mixture (sodium hydroxide, urea, and thiourea) and calcium chloride solution in combination with extrusion treatment did not lead to improvement in reducing sugar yield. However, extensive washing to get rid of solvents and enzymatic inhibit...

2010-01-01

166

Evaluating coal processing technology for the Indian power industry  

Energy Technology Data Exchange (ETDEWEB)

Due to the ever-increasing demand for electric power in India, the production of steam (non-coking) coal will continuously increase. Since most Indian coals contain high ash-forming minerals which result in the increased costs of transportation, boiler maintenance and refuse handling, the use of pre-combustion washing becomes a viable concept. However, many professionals in the Indian mining industry have debated on which of the many benefication techniques is the most appropriate for the pre-combustion cleaning. Through the comprehensive study presented herein, it is found that heavy media separation is more suitable than the jig process for most of the Indian coals. A discussion and flowsheet for the state-of-the-art plant design called the High Capacity Processor (HCP) using advanced coal cleaning techniques are presented.

1996-12-31

167

Effects of chemicals in the presence of cellophane on X-ray-induced point mutation and gene conversion in Aspergillus midulans  

Energy Technology Data Exchange (ETDEWEB)

The presence of washed or unwashed cellophane alone or together with a bleomycin, mitomycin C or hydrochlorothiazide, ('Esidrex') showed no appreciable effect on survival of either unirradiated or irradiated conidia. Irradiation for a period of 20min reduced the survival of conidia to 20%. The growth of irradiated conidia in the presence of bleomycin, mitomycin C or Esidrex is associated with a 2- to 3-fold increase in the frequency of gene convertants, but was not accompanied by an increase in point mutants. When conidia were grown on cellophane but otherwise treated as before the frequency of gene convertants was increased 8-fold, but induction of point mutants was negligible. This effect was the same for irradiated and unirradiated conidia. The environment created by the cellophane in contract with the medium appears to affect the action of each of the three compounds synergistically.

1984-08-01

168

Development of a stable cobalt-ruthenium Fischer-Tropsch catalyst. Technical progress report No. 17, 1 November 1993--31 December 1993  

Energy Technology Data Exchange (ETDEWEB)

Very high cobalt catalysts have been prepared on steamed and acid-washed y zeolite. These catalysts are very active. Some of them have proven to be very stable. Additionally, if provisions are made to control the temperature build up on the catalyst bed, low methane selectivities result. Additional work is indicated, for instance, perhaps even higher activity catalysts can result from higher levels of cobalt or changes in the catalyst preparation procedure. Since the issue of whether small amounts of ruthenium can promote the catalyst is not completely resolved, catalyst preparation procedure experiments should continue with ruthenium vs. ruthenium-free catalysts. For instance, different methods of impregnation and/or activation should be investigated.

1994-06-01

169

Cost minimization analysis for combinations of sampling techniques in bronchoscopy of endobronchial lesions  

British Library Electronic Table of Contents (United Kingdom)

SummaryBackground The choice of sampling techniques in bronchoscopy with sampling from a visible lesion will depend on the expected diagnostic yields and the costs of the sampling techniques. Aims The aim of this study was to determine the most economical combination of sampling techniques when approaching endobronchial visible lesions. Methods A cost minimization analysis was performed. All bronchoscopies from 2003 and 2004 at Haukeland university hospital, Bergen, Norway, were reviewed retrospectively for diagnostic yields. 162 patients with endobronchial disease were included. Potential sampling techniques used were biopsy, brushing, endobronchial needle aspiration (EBNA) and washings. Costs were estimated based on registration of equipment costs and personnel costs. Sensitivity analyse...

2009-01-01

170

Cleanliness of small precision swabs  

Energy Technology Data Exchange (ETDEWEB)

Small swabs are often dampened with a solvent when used to clean surfaces. Cotton swabs of the type sold in drug stores contain stearic acid, probably used as a lubricant during manufacture of the swab. Such swabs, dampened with a solvent and used to clean a surface, will leave a film of stearic acid on the surface. Several kinds of swabs are sold for industrial use, and some are described as suitable for use in clean room manufacturing. Nine different swabs, some cotton and some urethane foam, were extracted with isopropyl alcohol, CFC 113 (Freon TF or Genesolv D), or mixture of CFC 113 and methyl alcohol. After evaporation of the solvent, from 0.5 to 3.8 mg of an oil or grease remained. For critical applications, swabs should be washed with solvent before use.

1992-02-01

171

Chemical, electrical and electrochemical characterization of hybrid organic/inorganic polypyrrole/PW12O40^3^- coating deposited on polyester fabrics  

British Library Electronic Table of Contents (United Kingdom)

A study of the stability of conducting fabrics of polyester (PES) coated with polypyrrole/PW12O40^3^- (organic/inorganic hybrid material) in different pH solutions (1, 7, 13) has been done. Washing tests were also done in views of its possible application in electronic textiles such as antistatic clothing. X-ray photoelectron spectroscopy (XPS) studies have been done to quantify the amount of counter ion that remains in the polymer matrix and determine the doping ratio (N^+/N) after the different tests. Scanning electron microscopy (SEM) was also used to observe morphological differences after the different tests. Surface resistivity changes were measured by means of electrochemical impedance spectroscopy (EIS). Scanning electrochemical microscopy (SECM) was employed to measure changes in ...

2011-01-01

172

Aerogels from Unaltered Bacterial Cellulose: Application of scCO2 Drying for the Preparation of Shaped, Ultra-Lightweight Cellulosic Aerogels  

British Library Electronic Table of Contents (United Kingdom)

Bacterial cellulose produced by the gram-negative bacterium Gluconacetobacter xylinum was found to be an excellent native starting material for preparing shaped ultra-lightweight cellulose aerogels. The procedure comprises thorough washing and sterilization of the aquogel, quantitative solvent exchange and subsequent drying with supercritical carbon dioxide at 40 degreeC and 100 bar. The average density of the obtained dry cellulose aerogels is only about 8 mg cm-3 which is comparable to the most lightweight silica aerogels and distinctly lower than all values for cellulosic aerogels obtained from plant cellulose so far. SEM, ESEM and nitrogen adsorption experiments at 77 K reveal an open-porous network structure that consists of a comparatively high percentage of large mesopores and small...

2010-01-01

173

A TLD powder dosimetry measurement system for physical models of reference man  

International Nuclear Information System (INIS)

A tissue-equivalent dosimetry system has been developed for use in absorbed dose determinations with physical models of Reference Man. The dosimeter used was a thermo-luminescent dosimeter (TLD) powder which was mixed with a 'tissue-equivalent' material and modeled to closely approximate an organ's geometry and absorption properties. A separation procedure was developed by which the TLD powder was washed and the 'tissue-equivalent' material, a wax, was dissolved and extracted following the irradiation of the model. The procedure was tested to determine losses of powder, homogeneity of the powder's distribution throughout the wax, the effects of the separation procedure upon the powder and the statistical behavior of the procedure. The results of these tests established the feasibility of the procedure. A full-scale model of the pancreas was tested and the results supported the validity of the technique. (author)

1978-12-01

175

Statistical cut-off criterion  

International Nuclear Information System (INIS)

... radiation effects human populations low dose irradiation neoplasms radiation

1980-01-01

178

Potential Increases in Mortality due to Global Warming  

Science.gov (United States)

... predicting potential increases in human mortality due to global warming....

179

On-site burning, remote camp  

Science.gov (United States)

... wood, kitchen wastes, and human faeces. The ash from such waste burning shall be deposited and ...

182

Human Issues in Manufacturing Technology  

Science.gov (United States)

... qualified manufacturing employees. David Lichtinger, plant manager for Lord Corporation's aerospace products plant in ...

1992-09-01

187

CLINICOBACTERIOLOGICAL AND EPIDEMIOLOGICAL ...  

Science.gov (United States)

... Salmonella. Vdgella and Brucela also to the diagnosis of the septic- tylphoidal and enteric form of human peendotuber- auloals. ...

1963-11-01

188

Breath Test for Chemicals (Volatile Organic Compounds)  

Science.gov (United States)

Breath Tests; Human Volunteers; Pilot Study

2011-09-16

192

 

Wastenet

com/Descartes-Error-Emotion-Reason-Human/dp/014303622X/ref=cm_lmf_img_12_rdssss0\\

193

A playmate robot system for playing the rock-paper-scissors game with humans  

British Library Electronic Table of Contents (United Kingdom)

We have developed a playmate robot system for playing the rock-paper-scissors game with humans. The playmate robot recognizes the hand motions of a human using image processing without attaching any additional units to the human. The playmate robot system consists of three parts: a game management part, a hand motion recognition part, and a robot hand control part. The system functions as follows. (1) Before the game is played, the game management part decides on the motion of the robot hand from amongst rock, paper, and scissors. After the game is played, the robot develops a reaction using speech and facial expressions depending on the result of the game. (2) The hand motion recognition part recognizes the hand motion of the human. It does not use any additional units on the human?s body...

2011-01-01

194

Cloning and sequencing of cDNA encoding human DNA topoisomerase II and localization of the gene to chromosome region 17q21-22  

Energy Technology Data Exchange (ETDEWEB)

Two overlapping cDNA clones encoding human DNA topoisomerase II were identified by two independent methods. In one, a human cDNA library in phage {lambda} was screened by hybridization with a mixed oligonucleotide probe encoding a stretch of seven amino acids found in yeast and Drosophila DNA topoisomerase II; in the other, a different human cDNA library in a {lambda}gt11 expression vector was screened for the expression of antigenic determinants that are recognized by rabbit antibodies specific to human DNA topoisomerase II. The entire coding sequences of the human DNA topoisomerase II gene were determined from these and several additional clones, identified through the use of the cloned human TOP2 gene sequences as probes. Hybridization between the cloned sequences and mRNA and genomic DNA indicates that the human enzyme is encoded by a ...

1988-10-01

195

MEG studies of human vision: Retinotopic organization of V1  

Energy Technology Data Exchange (ETDEWEB)

A primary goal of noninvasive studies of human vision is to identify and characterize multiple visual areas in the human brain analogous to those identified in studies of nonhuman primates. By combining functional MEG measurements with images of individual anatomy derived from MRI, the authors hope to determine the location and arrangement of multiple visual areas in human cortex and to probe their functional significance. The authors have identified several different visual areas thus far which appear to be topographically organized. This paper focuses on the retinotopic characterization of the primary visual area (V1) in humans.

1993-12-31

196

The performance tests used the water scrubber for ruthenium rejection  

Energy Technology Data Exchange (ETDEWEB)

LEDF (Large Equipment Dismantling Facility) will be constructed for the purpose of decontaminating the high level {alpha} solid waste generated in oarai engineering center of JNC. And, main processing process of LEDF is incineration and melting system. LEDF will be intended to reduce the secondary waste that occurs along with the operation of the off gas processing equipment of incineration and melting system. It assumed that we are able to eliminate the adsorption tower using silica gel, if the decontamination factor to volatile ruthenium is able to expect in the packed scrubber that is established to remove harmful gas. Thereupon, we carried out this tests that eliminates the adsorption tower and reduces the secondary waste. The decontamination factor (DF) to the volatile ruthenium by the water scrubber is confirmed in the established institution which is in Tokai Works. However, decontamination factor differs and depends on the ruthenium concentration, harmful gas concentration, ...

2002-11-01

197

The performance tests used the water scrubber for ruthenium rejection  

International Nuclear Information System (INIS)

LEDF (Large Equipment Dismantling Facility) will be constructed for the purpose of decontaminating the high level #alpha# solid waste generated in oarai engineering center of JNC. And, main processing process of LEDF is incineration and melting system. LEDF will be intended to reduce the secondary waste that occurs along with the operation of the off gas processing equipment of incineration and melting system. It assumed that we are able to eliminate the adsorption tower using silica gel, if the decontamination factor to volatile ruthenium is able to expect in the packed scrubber that is established to remove harmful gas. Thereupon, we carried out this tests that eliminates the adsorption tower and reduces the secondary waste. The decontamination factor (DF) to the volatile ruthenium by the water scrubber is confirmed in the established institution which is in Tokai Works. However, decontamination factor differs and depends on the ruthenium concentration, harmful gas concentration, ...

198

The effect of pulse voltage and capacitance on biosorption of uranium by biomass derived from whiskey distillery spent wash  

Energy Technology Data Exchange (ETDEWEB)

Biosorption of uranium by residual biomass from The Old Bushmill`s Distillery Co. Ltd., Bushmills, Co. Antrim, Northern Ireland, following exposure to short and intense electric pulses has been examined. The biomass was prepared from the distillery spent wash and consisted of non-viable yeast and bacterial cells. As shown previously, untreated biomass had a maximum biosorption capacity of 170 mg uranium/g dry weight biomass. When biosorption reactions were placed between two electrodes and exposed to electric pulses with field strengths ranging from 1.25-3.25 kV/cm at a capacitance of 25 {mu}F, biosorption increased from 170 mg of uranium to 275 mg uranium/g dry weight biomass. The data were obtained from biosorption isotherm analyses and taken as the degree of biosorption at residual uranium concentrations of 3 mM. In addition, when the capacitance of the electric pulses increased from 0.25 {mu}F to 25 {mu}F at a fixed pulse field strength the degree of ...

1999-01-01

199

Estimation of the parameter covariance matrix for aone-compartment cardiac perfusion model estimated from a dynamic sequencereconstructed using map iterative reconstruction algorithms  

Energy Technology Data Exchange (ETDEWEB)

In dynamic cardiac SPECT estimates of kinetic parameters ofa one-compartment perfusion model are usually obtained in a two stepprocess: 1) first a MAP iterative algorithm, which properly models thePoisson statistics and the physics of the data acquisition, reconstructsa sequence of dynamic reconstructions, 2) then kinetic parameters areestimated from time activity curves generated from the dynamicreconstructions. This paper provides a method for calculating thecovariance matrix of the kinetic parameters, which are determined usingweighted least squares fitting that incorporates the estimated varianceand covariance of the dynamic reconstructions. For each transaxial slicesets of sequential tomographic projections are reconstructed into asequence of transaxial reconstructions usingfor each reconstruction inthe time sequence an iterative MAP reconstruction to calculate themaximum a priori reconstructed estimate. Time-activity curves for a sumof activity in a blood region inside the left ...

2004-01-01

200

A sample preparation for quantitative determination of magnesium in individual lymphocytes by electron probe X-ray microanalysis.  

Science.gov (United States)

We present a sample preparation method for measuring magnesium in individual whole lymphocytes by electron probe X-ray microanalysis. We use Burkitt's lymphoma cells in culture as the test sample and compare X-ray microanalysis of individual cells with atomic absorption analysis of pooled cell populations. We determine the magnesium peak-to-local continuum X-ray intensity ratio by electron probe X-ray microanalysis and calculate a mean cell magnesium concentration of 39 +/- 19 mmol/kg dry weight from analysis of 100 cells. We determine a mean cell magnesium concentration of 34 +/- 4 mmol/kg dry weight by atomic absorption analysis of pooled cells in three cell cultures. The mean cell magnesium concentrations determined by the two methods are not significantly different. We find a 10% coefficient of variation for both methods of analysis and a 30% coefficient of variation in magnesium concentration among individual cells by electron probe X-ray microanalysis. We ...

1986-01-01

201

Improving the PSA quality in the human reliability analysis of pre-accident human errors  

Energy Technology Data Exchange (ETDEWEB)

This paper describes the activities for improving the Probabilistic Safety Assessment (PSA) quality in the human reliability analysis (HRA) of the pre-accident human errors for the Korea Standard Nuclear Power Plant (KSNP). We evaluate the HRA results of the PSA for the KSNP and identify the items to be improved using the ASME PRA Standard. Evaluation results show that the ratio of items to be improved for pre-accident human errors is relatively high when compared with the ratio of those for post-accident human errors. They also show that more than 50% of the items to be improved for pre-accident human errors are related to the identification and screening analysis for them. In this paper, we develop the modeling guidelines for pre-accident human errors and apply them to the auxiliary feedwater system of the KSNP. Application results show that more than 50% of ...

2004-07-01

202

Improving the PSA quality in the human reliability analysis of pre-accident human errors  

International Nuclear Information System (INIS)

This paper describes the activities for improving the Probabilistic Safety Assessment (PSA) quality in the human reliability analysis (HRA) of the pre-accident human errors for the Korea Standard Nuclear Power Plant (KSNP). We evaluate the HRA results of the PSA for the KSNP and identify the items to be improved using the ASME PRA Standard. Evaluation results show that the ratio of items to be improved for pre-accident human errors is relatively high when compared with the ratio of those for post-accident human errors. They also show that more than 50% of the items to be improved for pre-accident human errors are related to the identification and screening analysis for them. In this paper, we develop the modeling guidelines for pre-accident human errors and apply them to the auxiliary feedwater system of the KSNP. Application results show that more than 50% of ...

2004-06-06

203

A Human Reliability Analysis of Post- Accident Human Errors in the Low Power and Shutdown PSA of KSNP  

International Nuclear Information System (INIS)

Korea Atomic Energy Research Institute, using the ANS low power and shutdown (LPSD) probabilistic risk assessment (PRA) Standard, evaluated the LPSD PSA model of the KSNP, Yonggwang Units 5 and 6, and identified the items to be improved. The evaluation results of human reliability analysis (HRA) of the post-accident human errors in the LPSD PSA model for the KSNP showed that 10 items among 19 items of supporting requirements for those in the ANS PRA Standard were identified as them to be improved. Thus, we newly carried out a HRA for post-accident human errors in the LPSD PSA model for the KSNP. Following tasks are the improvements in the HRA of post-accident human errors of the LPSD PSA model for the KSNP compared with the previous one: Interviews with operators in the interpretation of the procedure, modeling of operator actions, and the quantification results of human errors, ...

2010-05-01

204

Social-ecological science in the humane metropolis  

British Library Electronic Table of Contents (United Kingdom)

The Humane metropolis is a rubric to summarize and promote environmental and social quality in contemporary urban mosaics. Because cities, suburbs, and exurbs, as spatially extensive and connected socio-ecological systems, exhibit many negative features, the humane metropolis identifies a strategy to combat the ills and instill more positive and sustainable features and processes in urban systems. Because the humane metropolis as a program has arisen primarily from social motivations, there is the opportunity to articulate more explicitly the role that science can play in addressing the humane metropolis program and evaluating its success. A humane metropolis can be summarized as one that 1) protects and restores ecological services in cities and suburbs, 2) promotes physical and mental he...

2011-01-01

205

Report on {open_quotes}inspection of human subject research in intelligence and intelligence-related projects{close_quotes}  

Energy Technology Data Exchange (ETDEWEB)

Executive Order 12333, {open_quotes}United States Intelligence Activities,{close_quotes} (1) designates the Department`s intelligence element as a member of the Intelligence Community, and (2) states that no agency within the Intelligence community shall sponsor, contract for or conduct research on human subjects except in accordance with guidelines issued by the Department of Health and Human Services. The Federal policy for the Protection of Human Subjects, which was based on Department of Health and Human Services regulations, was promulgated in Title 10 Code of Federal Regulations Part 745 by the Department of Energy. The purpose of this inspection was to review the internal control procedures used by the Office of Nonproliferation and National Security to manage selected intelligence and intelligence-related projects that involve human subject research.

1996-01-16

206

Human cDNA mapping using fluorescence in situ hybridization. Final progress report, April 1, 1994--July 31, 1997  

Energy Technology Data Exchange (ETDEWEB)

The ultimate goal of this research is to generate and apply novel technologies to speed completion and integration of the human genome map and sequence with biomedical problems. To do this, techniques were developed and genome-wide resources generated. This includes a genome-wide Mapped and Integrated BAC/PAC Resource that has been used for gene finding, map completion and anchoring, breakpoint definition and sequencing. In the last period of the grant, the Human Mapped BAC/PAC Resource was also applied to determine regions of human variation and to develop a novel paradigm of primate evolution through to humans. Further, in order to more rapidly evaluate animal models of human disease, a BAC Map of the mouse was generated in collaboration with the MTI Genome Center, Dr. Bruce Birren.

1997-12-31

207

Homologous radioimmunoassay for human prolactin  

International Nuclear Information System (INIS)

Although thee are descriptions of a range of radioimmunoassays for human prolactin in various biological fluids, only one of these is an homologous assay using human prolactin as the reference standard and tracer as well and an anti-human prolactin antiserum (Sinha, Y.N., Selby, F.W.; Lewis, U.; and Vanderlaan, W.P., 1973, J. Clin. Endocr., Vol. 36, 509). A homologous radioimmunoassay using human putuitary prolactin has been developed. The separation method is based on the double antibody solid phase system. Cross reactivity with human growth hormone (GH), placental lactogen (HPL), the pituitary protein hormones and prolactins of various species were studied as were values found in normal subjects in basal conditions and after a TRH injection. (author).

208

Screening for von Willebrand disease: contribution of an automated assay for von Willebrand factor activity.  

Science.gov (United States)

Summary.? Measuring von Willebrand factor (VWF) activity is essential to the diagnosis of von Willebrand disease (VWD). The VWF activity is usually assessed based on measurement of the ristocetin cofactor (VWF:RCo). However, that test is technically challenging and has high intra- and inter-assay variabilities. The HemosIL VWF activity (VWF:AC) is a fully automated assay, recently proposed as a good alternative to VWF:RCo for VWD diagnosis. This study was undertaken to assess this new method. First, the analytical performance of VWF:AC on an automated coagulo-meter (ACLTop) was determined, and then this new method was compared with VWF:RCo and the platelet function analyzer (PFA100) for 160 patients referred for VWD screening. The VWF:AC achieved acceptable precision with within-run and between-run coefficients of variation ranging from 2.3% to 14.1%, and linearity from 10% to 100%. Despite some marked differences between VWF:AC and VWF:RCo for 10 plasmas tested, ...

2011-09-28

209

Intensive combined modality therapy including low-dose TBI in high-risk Ewing's sarcoma patients  

International Nuclear Information System (INIS)

Twenty-four high-risk Ewing's sarcoma patients were treated on an intensive combined modality protocol including low-dose fractionated total body irradiaiton (TBI) and autologous bone marrow infusion (ABMI). Twenty patients (83%) achieved a complete clinical response to the primary and/or metastatic sites following induction therapy. The median disease-free interval was 18 months, and nine patients remain disease-free with a follow-up of 22 to 72 months. Local failure as a manifestation of initial relapse occurred in only three patients (15%), each having synchronous distant failure. Eight patients failed initially with only distant metastases, usually within 1-2 years following a complete clinical response. Two patterns of granulocyte recovery following consolidative therapy (including TBI and ABMI) were recognized. The time to platelet recovery was different for the groups with early and late granulocyte recovery. Patients with late recovery did not tolerate ...

210

Biomarkers of fibrosis and impaired liver function in chronic hepatitis C: how well do they predict clinical outcomes?  

DEFF Research Database (Denmark)

PURPOSE OF REVIEW: To review the recent literature on the prognostic value of biomarkers of liver fibrosis and impaired liver function in patients with chronic hepatitis C with or without HIV coinfection. RECENT FINDINGS: A combination of standard blood tests seems to be useful in identifying patients at risk of liver-related complications. Findings from studies investigating the validity of the Model for End-Stage Liver Disease (MELD) score in HIV-infected liver transplant candidates are conflicting. Two large studies of HIV/hepatitis C virus (HCV) coinfected patients have shown that plasma levels of the fibrosis marker hyaluronic acid are a strong predictor of clinical complications. A smaller study found hyaluronic acid and two other fibrosis tests, aspartate aminotransferase-to-platelet ratio index (APRI) and Fib-4, to be independent predictors of mortality when included in models with the MELD or the Child-Pugh-Turcotte scores. SUMMARY: Although the data are ...

2010-01-01

211

Whole-genome shotgun assembly and comparison of human genome assemblies  

UK PubMed Central (United Kingdom)

We report a whole-genome shotgun assembly (called WGSA) of the human genome generated at Celera in 2001. The Celera-generated shotgun data set consisted of 27 million sequencing reads organized in pairs...Full Text Available

2004-02-17

212

Uptake and Intracellular Activity of Moxifloxacin in Human Neutrophils and Tissue-Cultured Epithelial Cells  

UK PubMed Central (United Kingdom)

The penetration by moxifloxacin of human neutrophils (polymorphonuclear leukocytes [PMN]) and tissue-cultured epithelial cells (McCoy cells) was evaluated by a fluorometric assay. At...Full Text Available

1999-01-01

213

Unloaded Shortening Velocity of Voluntarily and Electrically Activated Human Dorsiflexor Muscles In Vivo  

UK PubMed Central (United Kingdom)

We have previously shown that unloaded shortening velocity (V0) of human plantar flexors can be determined in vivo, by applying the “slack test”...Full Text Available

214

Transcriptional profile of isoproterenol-induced cardiomyopathy and comparison to exercise-induced cardiac hypertrophy and human cardiac failure  

UK PubMed Central (United Kingdom)

BackgroundIsoproterenol-induced cardiac hypertrophy in mice has been used in a number of studies to model human cardiac disease. In this study, we compared the transcriptional response...Full Text Available

215

Transcription induces strand-specific mutations at the 5? end of human genes  

UK PubMed Central (United Kingdom)

A regional analysis of nucleotide substitution rates along human genes and their flanking regions allows us to quantify the effect of mutational mechanisms associated with transcription in germ line...Full Text Available

2008-08-01

216

Thymol, a constituent of thyme essential oil, is a positive allosteric modulator of human GABAA receptors and a homo-oligomeric GABA receptor from Drosophila melanogaster  

UK PubMed Central (United Kingdom)

The GABA-modulating and GABA-mimetic activities of the monoterpenoid thymol were explored on human GABAA and Drosophila melanogaster...Full Text Available

2003-12-01

217

Theoretical Design of a Gene Therapy To Prevent AIDS but Not Human Immunodeficiency Virus Type 1 Infection  

UK PubMed Central (United Kingdom)

Recent reports confirm that, due to the presence of long-lived, latently infected cell populations, eradication of human immunodeficiency virus type 1 (HIV-1) from infected patients by using antiretroviral...Full Text Available

2003-09-01

218

The Relationship of Urinary Metabolites of Carbaryl/Naphthalene and Chlorpyrifos with Human Semen Quality  

UK PubMed Central (United Kingdom)

Most of the general population is exposed to carbaryl and other contemporary-use insecticides at low levels. Studies of laboratory animals, in addition to limited human data, show an association between...Full Text Available

2004-12-01

219

Susceptibility of human primary neuronal cells to Xenotropic Murine Leukemia Virus-related (XMRV) virus infection  

UK PubMed Central (United Kingdom)

BackgroundXenotropic Murine Leukemia Virus-related (XMRV) virus is a recently identified mouse gammaretrovirus that has the ability to infect certain human cells. In this study,...Full Text Available

220

Stability of Plasma Human Immunodeficiency Virus Load in VACUTAINER PPT Plasma Preparation Tubes during Overnight Shipment  

UK PubMed Central (United Kingdom)

VACUTAINER PPT plasma preparation tubes were evaluated to determine the effects of various handling and shipping conditions on plasma human immunodeficiency virus (HIV) load determinations. Plasmas...Full Text Available

2000-01-01

221

Space and the parietal cortex  

UK PubMed Central (United Kingdom)

Current views of the parietal cortex have difficulty accommodating the human inferior parietal lobe (IPL) within a simple dorsal versus ventral stream dichotomy. In humans, lesions of the right IPL...Full Text Available

2007-01-01

222

Should we clone human beings? Cloning as a source of tissue for transplantation.  

UK PubMed Central (United Kingdom)

The most publicly justifiable application of human cloning, if there is one at all, is to provide self-compatible cells or tissues for medical use, especially transplantation. Some have argued that...Full Text Available

1999-04-01

223

Shelterin complex and associated factors at human telomeres  

UK PubMed Central (United Kingdom)

The processes regulating telomere function have major impacts on fundamental issues in human cancer biology. First, active telomere maintenance is almost always required for full oncogenic transformation...Full Text Available

2011-03-01

224

Sequence space coverage, entropy of genomes and the potential to detect non-human DNA in human samples  

UK PubMed Central (United Kingdom)

BackgroundGenomes store information for building and maintaining organisms. Complete sequencing of many genomes provides the opportunity to study and compare global information properties...Full Text Available

225

Sequence features that drive human promoter function and tissue specificity  

UK PubMed Central (United Kingdom)

Promoters are important regulatory elements that contain the necessary sequence features for cells to initiate transcription. To functionally characterize a large set of human promoters, we measured...Full Text Available

2010-07-01

226

STR References 3001-3250  

Science.gov (United States)

Journal of Human Genetics. 82: 873-882. 3134. Schulz, I., Schneider, P. M., Olek, K, Rothschild, M. A., and Tsokos, M. (2006) Examination of Postmortem Animal Interference to Human...

2009-03-16

227

Research on ethics in two large Human Biomonitoring projects ECNIS and NewGeneris: a bottom up approach  

UK PubMed Central (United Kingdom)

Assessment of ethical aspects and authorization by ethics committees have become a major constraint for health research including human subjects. Ethical reference values often are extrapolated from...Full Text Available

228

Replication Stress Induces Genome-wide Copy Number Changes in Human Cells that Resemble Polymorphic and Pathogenic Variants  

UK PubMed Central (United Kingdom)

Copy number variants (CNVs) are an important component of genomic variation in humans and other mammals. Similar de novo deletions and duplications, or copy number changes (CNCs), are now known to be...Full Text Available

2009-03-13

229

Reconstruction of the complete human cytomegalovirus genome in a BAC reveals RL13 to be a potent inhibitor of replication  

UK PubMed Central (United Kingdom)

Human cytomegalovirus (HCMV) in clinical material cannot replicate efficiently in vitro until it has adapted by mutation. Consequently, wild-type HCMV differ fundamentally from the passaged strains...Full Text Available

2010-09-01

230

Rearrangement of a common cellular DNA domain on chromosome 4 in human primary liver tumors.  

UK PubMed Central (United Kingdom)

Hepatitis B virus (HBV) DNA integration has been shown to occur frequently in human hepatocellular carcinomas. We have investigated whether common cellular DNA domains might be rearranged, possibly...Full Text Available

1988-02-01

231

Reaction of human albumin with aspirin in vitro: mass spectrometric identification of acetylated lysines 199, 402, 519, and 545  

UK PubMed Central (United Kingdom)

The aspirin esterase activity of human plasma is due to butyrylcholinesterase and albumin. Our goal was to identify the amino acid residues involved in the aspirin esterase activity of albumin....Full Text Available

2010-03-01

232

Quantitation of Antibody to Non-Hemagglutinating Viruses by Single Radial Hemolysis: Serological Test for Human Coronaviruses  

UK PubMed Central (United Kingdom)

A single radial hemolysis test was developed for quantitation of specific antibody to non-hemagglutinating viruses. With the human coronaviruses as models, this test utilizes the binding properties...Full Text Available

1977-06-01

233

Proteome of human colon cancer stem cells: A comparative analysis  

UK PubMed Central (United Kingdom)

AIM: To isolate and identify the biological characteristics of human colon cancer stem cells (SW1116 cells) and further study their proteome.METHODS: SW1116 cells were isolated and cultured with...Full Text Available

2011-03-14

234

Propagation of human embryonic and induced pluripotent stem cells in an indirect co-culture system  

UK PubMed Central (United Kingdom)

We have developed and validated a microporous poly(ethylene terephthalate) membrane-based indirect co-culture system for human pluripotent stem cell (hPSC) propagation, which allows real-time...Full Text Available

2010-03-05

235

Predicting the carcinogenicity of chemicals in humans from rodent bioassay data.  

UK PubMed Central (United Kingdom)

Regulatory agencies currently rely on rodent carcinogenicity bioassay data to predict whether or not a given chemical poses a carcinogenic threat to humans. We argue that it is always more useful to...Full Text Available

1991-08-01

236

Polymorphisms associated with type 2 diabetes in familial longevity: The Leiden Longevity Study  

UK PubMed Central (United Kingdom)

Human longevity is in part genetically determined, and the insulin/IGF-1 signal transduction (IIS) pathway has consistently been implicated. In humans, type 2 diabetes is a frequent disease that results...Full Text Available

237

Polymorphic Regions Affecting Human Height Also Control Stature in Cattle  

UK PubMed Central (United Kingdom)

Orthologous positions of 55 genes associated with height in four human populations were located on the bovine genome. Single nucleotide polymorphisms close to eight of these genes were significantly...Full Text Available

2011-03-01

238

Peptides of human bronchial mucus glycoproteins. Size determination by electron microscopy and by biosynthetic experiments.  

UK PubMed Central (United Kingdom)

Secreted human bronchial mucins, directly collected from macroscopically healthy bronchial mucosa, were prepared in the presence of six proteinase inhibitors, and analysed by electron microscopy. These...Full Text Available

1987-11-15

239

Pathogenesis of the Human Opportunistic Pathogen Pseudomonas aeruginosa PA14 in Arabidopsis1  

UK PubMed Central (United Kingdom)

The human opportunistic pathogen Pseudomonas aeruginosa strain PA14 is a multihost pathogen that can infect Arabidopsis. We found that PA14 pathogenesis in Arabidopsis involves the...Full Text Available

2000-12-01

240

Palindromic Sequence Plays a Critical Role in Human Foamy Virus Dimerization  

UK PubMed Central (United Kingdom)

The retroviral RNA genome is dimeric, consisting of two identical strands of RNA linked near their 5′ ends by a dimer linkage structure. Previously it was shown that human foamy virus (HFV)...Full Text Available

2001-04-01

241

Oxygen deprivation inhibits basal keratinocyte proliferation in a model of human skin and induces regio-specific changes in the distribution of epidermal adherens junction proteins, aquaporin-3, and glycogen  

UK PubMed Central (United Kingdom)

It is generally accepted that hypoxia and recovery from oxygen deprivation contribute to the breakdown and ulceration of human skin. The effects of these stresses on proliferation, differentiation...Full Text Available

2009-01-01

242

Overexpression of human virus surface glycoprotein precursors induces cytosolic unfolded protein response in Saccharomyces cerevisiae  

UK PubMed Central (United Kingdom)

BackgroundThe expression of human virus surface proteins, as well as other mammalian glycoproteins, is much more efficient in cells of higher eukaryotes rather than yeasts. The limitations...Full Text Available

243

Observations on the use of solid-phase-coupled antibodies in the radioimmunoassay of human placental lactogen  

UK PubMed Central (United Kingdom)

A detailed comparative assessment was made of the use of solid-phase-coupled antibodies in radioimmunoassay, by using an assay for human placental lactogen as a model system. The major advantages of...Full Text Available

1974-03-01

244

Numerical field calculations considering the human subject for engineering and safety assurance in MRI  

UK PubMed Central (United Kingdom)

Numerical calculations of static, switched, and radiofrequency (RF) electromagnetic (EM) fields considering the geometry and EM properties of the human body are used increasingly in MRI to explain...Full Text Available

2009-11-01

245

Novel Human Erythrovirus Associated with Transient Aplastic Anemia  

UK PubMed Central (United Kingdom)

Erythrovirus (formerly parvovirus) B19 causes a wide range of diseases in humans, including anemia due to aplastic crisis. Diagnosis of B19 infection relies on serology and the detection of viral DNA...Full Text Available

1999-08-01

246

Nepotistic cooperation in non-human primate groups  

UK PubMed Central (United Kingdom)

Darwin was struck by the many similarities between humans and other primates and believed that these similarities were the product of common ancestry. He would be even more impressed by the similarities...Full Text Available

2009-11-12

247

Natural mutagenesis of human genomes by endogenous retrotransposons  

UK PubMed Central (United Kingdom)

SUMMARYTwo abundant classes of mobile elements, namely Alu and L1 elements, continue to generate new retrotransposon insertions in human genomes. Estimates suggest that these...Full Text Available

2010-06-25

248

NF-kappaB mediates the survival of human bronchial epithelial cells exposed to cigarette smoke extract  

UK PubMed Central (United Kingdom)

BackgroundWe have previously reported that low concentrations of cigarette smoke extract induce DNA damage without leading to apoptosis or necrosis in human bronchial epithelial...Full Text Available

2008-01-01

249

Mouse model predicts effects of smoking and varenicline on event-related potentials in humans  

UK PubMed Central (United Kingdom)

Background:Nicotine alters auditory event-related potentials (ERPs) in rodents and humans and is an effective treatment for smoking cessation. Less is known about the effects of...Full Text Available

2010-06-01

250

Modulation of the human hair follicle pigmentary unit by corticotropin-releasing hormone and urocortin peptides  

UK PubMed Central (United Kingdom)

Human skin is a local source of corticotropin-releasing hormone (CRH) and expresses CRH and CRH receptors (CRH-R) at mRNA and protein levels. Epidermal melanocytes respond to CRH by induction...Full Text Available

2006-05-01

251

Mechanistic fracture criteria for the failure of human cortical bone  

Energy Technology Data Exchange (ETDEWEB)

A mechanistic understanding of fracture in human bone is critical to predicting fracture risk associated with age and disease. Despite extensive work, a mechanistic framework for describing how the underlying microstructure affects the failure mode in bone is lacking.

2002-12-13

252

Measuring the thickness of the human cerebral cortex from magnetic resonance images  

UK PubMed Central (United Kingdom)

Accurate and automated methods for measuring the thickness of human cerebral cortex could provide powerful tools for diagnosing and studying a variety of neurodegenerative and psychiatric disorders....Full Text Available

2000-09-26

253

Lotus (Nelumbo nuficera) flower essential oil increased melanogenesis in normal human melanocytes  

UK PubMed Central (United Kingdom)

In this study, the essential oil from lotus flower extract, including petals and stamens, was assessed with regard to its effects on melanogenesis in human melanocytes. The lotus flower essential oil...Full Text Available

2009-07-31

254

Loss of ?-III spectrin leads to Purkinje cell dysfunction recapitulating the behaviour and neuropathology of SCA5 in humans  

UK PubMed Central (United Kingdom)

Mutations in SPTBN2, the gene encoding β-III spectrin, cause spinocerebellar ataxia type 5 in humans (SCA5), a neurodegenerative disorder resulting in loss of motor...Full Text Available

2010-04-07

255

Lin28a transgenic mice manifest size and puberty phenotypes identified in human genetic association studies  

UK PubMed Central (United Kingdom)

Recently, genome-wide association studies (GWAS) have linked the human LIN28B locus to height and timing of menarche [1-Full Text Available

2010-07-01

256

Lentiviral vector-mediated stable expression of sTNFR-Fc in human macrophage and neuronal cells as a potential therapy for neuroAIDS  

UK PubMed Central (United Kingdom)

BackgroundHuman immunodeficiency virus type 1 (HIV-1) infection frequently causes neurologic disease, which is the result of viral replication and activation of macrophages and microglia...Full Text Available

257

Isolation of Mycoplasma pneumoniae from the human urogenital tract.  

UK PubMed Central (United Kingdom)

Mycoplasma pneumoniae is a common etiologic agent of lower respiratory tract infections in humans. However, it has been reported previously that the organism has occasionally been isolated from sites...Full Text Available

1995-11-01

258

Interaction of the New Ketolide ABT-773 (Cethromycin) with Human Polymorphonuclear Neutrophils and the Phagocytic Cell Line PLB-985 In Vitro  

UK PubMed Central (United Kingdom)

A classical velocity centrifugation technique was used to study the in vitro uptake of the new ketolide ABT-773 by human polymorphonuclear neutrophils (PMNs) and a myelomonoblastic cell line, PLB-985,...Full Text Available

2004-04-01

259

Individual Predisposition, Household Clustering and Risk Factors for Human Infection with Ascaris lumbricoides: New Epidemiological Insights  

UK PubMed Central (United Kingdom)

BackgroundMuch of our current understanding of the epidemiology of Ascaris lumbricoides infections in humans has been acquired by analyzing worm count data. These...Full Text Available

260

Increased SRF transcriptional activity in human and mouse skeletal muscle is a signature of insulin resistance  

UK PubMed Central (United Kingdom)

Insulin resistance in skeletal muscle is a key phenotype associated with type 2 diabetes (T2D) for which the molecular mediators remain unclear. We therefore conducted an expression analysis of human...Full Text Available

2011-03-01

261

In vitro dimerization of human immunodeficiency virus type 1 (HIV-1) spliced RNAs  

UK PubMed Central (United Kingdom)

The human immunodeficiency virus type 1 (HIV-1) packages its genomic RNA as a dimer of homologous RNA molecules that has to be selected among a multitude of cellular and viral RNAs. Interestingly, spliced...Full Text Available

2007-12-01

262

Impact of sphingomyelin levels on coronary heart disease and left ventricular systolic function in humans  

UK PubMed Central (United Kingdom)

Sphingomyelin (SM) is an abundant phospholipid in cell membranes and in lipoproteins. In human plasma, SM is mainly found in atherogenic lipoproteins; therefore, higher levels of SM may promote atherogenesis....Full Text Available

263

Immunoreactive properties of anti-thyroglobulin autoantibodies isolated by affinity chromatography from human thyroiditis serum.  

UK PubMed Central (United Kingdom)

A Sepharose-coupled 19S human thyroglobulin has been used as an immunoadsorbent to isolate anti-thyroglobulin autoantibodies and to evaluate the antigen-antibody interactions. With the system proposed...Full Text Available

1978-02-01

264

Immunochemical detection of glycated lens crystallins and their circulating autoantibodies in human serum during aging  

UK PubMed Central (United Kingdom)

PurposeThe aim of this investigation was to exploit lens-specific glycated crystallins as an immunogen to detect human glycated crystallins and their circulating autoantibodies in...Full Text Available

265

Identification of two homologs of the Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) in retroperitoneal fibromatosis of different macaque species.  

UK PubMed Central (United Kingdom)

Simian retroperitoneal fibromatosis (RF) is a vascular fibroproliferative neoplasm which has many morphological and histological similarities to human Kaposi's sarcoma (KS). Like epidemic KS in AIDS...Full Text Available

1997-05-01

266

Identification of a stem cell candidate in the normal human prostate gland  

UK PubMed Central (United Kingdom)

Stem cells of the human prostate gland have not yet been identified utilizing a structural biomarker. We have discovered a new prostatic epithelial cell phenotype-expressing cytokeratin 6a (Ck6a+...Full Text Available

2005-03-01

267

INTRAVITREAL HUMAN IMMUNE GLOBULIN IN A RABBIT MODEL OF STAPHYLOCOCCUS AUREUS TOXIN-MEDIATED ENDOPHTHALMITIS: A POTENTIAL ADJUNCT IN THE TREATMENT OF ENDOPHTHALMITIS  

UK PubMed Central (United Kingdom)

ABSTRACTObjectivesTo test the feasibility of human immune globulin (IG, Gamimune N, 10%) as a new treatment for endophthalmitis, the ocular tolerance, distribution,...Full Text Available

2004-12-01

268

Human papillomavirus infection in Beijing, People's Republic of China: a population-based study  

UK PubMed Central (United Kingdom)

Background:No recent data exist on human papillomavirus (HPV) infection in Beijing, People's Republic of China.Materials and methodWe interviewed...Full Text Available

2009-11-03

269

Human papillomavirus infection and anal carcinoma. Retrospective analysis by in situ hybridization and the polymerase chain reaction.  

UK PubMed Central (United Kingdom)

To examine the association of human papillomavirus (HPV) infection with anal squamous cell carcinoma, the authors applied the highly sensitive polymerase chain reaction (PCR) and in situ hybridization...Full Text Available

1992-06-01

270

Human monkeypox, 1970-79*  

UK PubMed Central (United Kingdom)

Increasing attention has been given to human monkeypox since the achievement of global smallpox eradication. Monkeypox, which was first described in Central Africa in 1970, resembles smallpox clinically...Full Text Available

1980-01-01

271

Human milk as a bioindicator for body burden of PCDDs, PCDFs, organochlorine pesticides, and PCBs.  

UK PubMed Central (United Kingdom)

In the State Laboratory of North Rhine-Westphalia for Food, Pharmaceutical and Environmental Chemistry (Chemisches Landesuntersuchungsamt), more than 600 individual human milk samples have been analyzed...Full Text Available

1994-01-01

272

Human hair genealogies and stem cell latency  

UK PubMed Central (United Kingdom)

BackgroundStem cells divide to reproduce themselves and produce differentiated progeny. A fundamental problem in human biology has been the inability to measure how often stem cells...Full Text Available

273

Human Immunodeficiency Virus-1 Inhibition of Immunoamphisomes in Dendritic Cells Impairs Early Innate and Adaptive Immune Responses  

UK PubMed Central (United Kingdom)

SUMMARYDendritic cells (DCs) in mucosal surfaces are early targets for human immunodeficiency virus-1 (HIV-1). DCs mount rapid and robust immune responses upon pathogen encounter....Full Text Available

2010-05-28

274

Glycolipids of human primary testicular germ cell tumours.  

UK PubMed Central (United Kingdom)

The glycolipid content of human non-seminomatous germ cell tumour cell lines correlates with their differentiation lineage. To analyse whether this reflects the situation in primary tumours, we studied...Full Text Available

1996-07-01

275

Genomic Evidence for the Evolution of Streptococcus equi: Host Restriction, Increased Virulence, and Genetic Exchange with Human Pathogens  

UK PubMed Central (United Kingdom)

The continued evolution of bacterial pathogens has major implications for both human and animal disease, but the exchange of genetic material between host-restricted pathogens is rarely considered....Full Text Available

2009-03-01

276

Genetics of the mammalian phenylalanine hydroxylase system. Studies of human liver phenylalanine hydroxylase subunit structure and of mutations in phenylketonuria.  

UK PubMed Central (United Kingdom)

Phenylalanine hydroxylase was purified from crude extracts of human livers which show enzyme activity by usine two different methods: (a) affinity chromatography and (b) immunoprecipitation with an...Full Text Available

1979-08-01

277

Genetic heterogeneity in human T-cell leukemia/lymphoma virus type II.  

UK PubMed Central (United Kingdom)

DNA from the peripheral blood mononuclear cells of 17 different individuals infected with human T-cell lymphoma/leukemia virus type II (HTLV-II) was successfully amplified by the polymerase chain reaction...Full Text Available

1993-03-01

278

Genetic Elucidation of Human Hyperosmia to Isovaleric Acid  

UK PubMed Central (United Kingdom)

The genetic basis of odorant-specific variations in human olfactory thresholds, and in particular of enhanced odorant sensitivity (hyperosmia), remains largely unknown. Olfactory receptor (OR) segregating...Full Text Available

2007-11-01

279

Gene-Environment Interactions and Epigenetic Basis of Human Diseases  

UK PubMed Central (United Kingdom)

Most human diseases are related in some way to the loss or gain in gene functions. Regulation of gene expression is a complex process. In addition to genetic mechanisms, epigenetic causes are...Full Text Available

2008-01-01

280

Gene Signature For Predicting Survival Outcome Of Human Hepatocellular Carcinoma (HCC) - Technology Transfer Center  

Science.gov (United States)

The National Cancer Institute Laboratory of Human Carcinogenesis is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize a gene signature for prognosis of hepatocellular carcinoma in patients.

281

GSFC Information Systems Technology Developments Supporting the Vision for Space Exploration.  

Science.gov (United States)

The Vision for Space Exploration will guide NASA's future human and robotic space activities. The broad range of human and robotic missions now being planned will require the development of new system-level capabilities enabled by emerging new technologie...

2005-01-01

282

Flow Cytometry of Human Primary Epidermal and Follicular Keratinocytes  

UK PubMed Central (United Kingdom)

Objective: The aim of this study was to characterize using flow cytometry cultured human primary keratinocytes isolated from the epidermis and hair follicles by different methods. Methods:...Full Text Available

283

Extraction of immune and inflammatory cells from human lung parenchyma: evaluation of an enzymatic digestion procedure.  

UK PubMed Central (United Kingdom)

The inflammatory and immune cell populations of the human lung parenchyma have not been characterized in detail. This report describes a novel and efficient procedure for their extraction. Histologically...Full Text Available

1986-10-01

284

Expression of genes for bone morphogenetic proteins BMP-2, BMP-4 and BMP-6 in various parts of the human skeleton  

UK PubMed Central (United Kingdom)

BackgroundDifferences in duration of bone healing in various parts of the human skeleton are common experience for orthopaedic surgeons. The reason for these differences is not obvious...Full Text Available

285

Expression of calbindin-D28k and its regulation by estrogen in the human endometrium during the menstrual cycle  

UK PubMed Central (United Kingdom)

Human endometrium resists embryo implantation except during the 'window of receptivity'. A change in endometrial gene expression is required for the development of receptivity. Uterine calbindin-D28k...Full Text Available

286

Evolving hard problems: Generating human genetics datasets with a complex etiology  

UK PubMed Central (United Kingdom)

BackgroundA goal of human genetics is to discover genetic factors that influence individuals' susceptibility to common diseases. Most common diseases are thought to result from the...Full Text Available

287

Evidence for increased in vitro recombination with insertion of human hepatitis B virus DNA.  

UK PubMed Central (United Kingdom)

Chromosomal translocation, deletion, and inversion/duplication directly linked to hepatitis B virus (HBV) DNA integration occur frequently in host DNA of human hepatocellular carcinomas. To test the...Full Text Available

1991-10-15

288

Epidermal keratinocytes do not activate peripheral T-cells: interleukin-10 as a possible regulator  

UK PubMed Central (United Kingdom)

The immunogenicity of allogeneic cultured human epidermal keratinocytes (cHEKs) has been studied in several models with contradictory results. We studied human T-cell activation in an in vitro...Full Text Available

2008-11-01

289

Effects of small doses of ionizing radiation on human health  

Energy Technology Data Exchange (ETDEWEB)

The risks to human health from small doses of ionizing radiation raise questions which remain largely unanswered. This paper begins by explaining the historical background to this subject; it goes on to discuss recent developments and concludes with a personal view of the dose-reponse relationship. (author).

1997-12-01

290

Effects of small doses of ionizing radiation on human health  

International Nuclear Information System (INIS)

The risks to human health from small doses of ionizing radiation raise questions which remain largely unanswered. This paper begins by explaining the historical background to this subject; it goes on to discuss recent developments and concludes with a personal view of the dose-reponse relationship. (author).

1997-01-01

291

Distribution of lead-203 in human peripheral blood in vitro.  

UK PubMed Central (United Kingdom)

In-vitro experiments using 203Pb were performed to identify the lead binding components in human peripheral blood. The distribution of lead in plasma, in the red cell membrane, and within the red cell...Full Text Available

1980-02-01

292

Differential Gene Expression in Primary Human Skin Keratinocytes and Fibroblasts in Response to Ionizing Radiation  

UK PubMed Central (United Kingdom)

Although skin is usually exposed during human exposures to ionizing radiation, there have been no thorough examinations of the transcriptional response of skin fibroblasts and keratinocytes...Full Text Available

2009-07-01

293

Detection and Identification of Bartonella Species Pathogenic for Humans by PCR Amplification Targeting the Riboflavin Synthase Gene (ribC)  

UK PubMed Central (United Kingdom)

Several Bartonella species have now been implicated as human pathogens. The recovery of these fastidious organisms in the clinical microbiology laboratory remains difficult, and current...Full Text Available

2003-03-01

294

Detection and Differentiation of Cryptosporidium spp. in Human Clinical Samples by Use of Real-Time PCR?  

UK PubMed Central (United Kingdom)

Real-time PCR has the potential to streamline detection and identification of Cryptosporidium spp. in human clinical samples. In the present...Full Text Available

2011-03-01

295

Dengue Fever in Humanized NOD/SCID Mice  

UK PubMed Central (United Kingdom)

The increased transmission and geographic spread of dengue fever (DF) and its more severe presentation, dengue hemorrhagic fever (DHF), make it the most important mosquito-borne viral disease of humans...Full Text Available

2005-11-01

296

Cytokine Responses to Treponema pectinovorum and Treponema denticola in Human Gingival Fibroblasts  

UK PubMed Central (United Kingdom)

Human gingival fibroblasts were challenged with Treponema pectinovorum and Treponema denticola to test three specific hypotheses: (i) these treponemes induce different...Full Text Available

2000-09-01

297

Crystallization and preliminary X-ray analysis of human liver ?-enolase  

UK PubMed Central (United Kingdom)

Enolase is a multifunctional enzyme that plays important roles in many biological and disease processes. α-Enolase from human liver (hENO1) was expressed as a soluble protein and purified by...Full Text Available

298

Crystal structure of the human adenovirus proteinase with its 11 amino acid cofactor.  

UK PubMed Central (United Kingdom)

The three-dimensional structure of the human adenovirus-2 proteinase complexed with its 11 amino acid cofactor, pVIc, was determined at 2.6 A resolution by X-ray crystallographic analysis. The fold...Full Text Available

1996-04-15

299

Contribution to the radionuclide x-ray fluorescence analysis of human blood and plasma  

International Nuclear Information System (INIS)

A photon-induced x-ray fluorescence method allowing the simultaneous determination of iron, copper, zinc, bromine and rubidium in human blood and blood plasma samples is described. The method is reliable and has a good sensitivity for a wide range of elements. (author).

1986-04-01

300

Confirmation of human Campylobacter concisus isolates misidentified as Campylobacter mucosalis and suggestions for improved differentiation between the two species.  

UK PubMed Central (United Kingdom)

A strain from human diarrhea originally identified as Campylobacter mucosalis (NCTC 12408) was examined by using 64 phenotypic characters. The similarity of this strain to 297 isolates of Campylobacter,...Full Text Available

1994-09-01

301

Colour television, an imitation of the human visual system.  

UK PubMed Central (United Kingdom)

Colour television is examined as an attempt to imitate the human visual system in image formation, spectral sensitivities, adaptation, contrast effects, signal processing, signal modulation, signal...Full Text Available

1975-07-01

302

Climate Change, Genetics or Human Choice: Why Were the Shells of Mankind's Earliest Ornament Larger in the Pleistocene Than in the Holocene?  

UK PubMed Central (United Kingdom)

BackgroundThe southern African tick shell, Nassarius kraussianus (Dunker, 1846), has been identified as being the earliest known ornamental object used by human...Full Text Available

303

Characterization of the functional gene and several processed pseudogenes in the human triosephosphate isomerase gene family.  

UK PubMed Central (United Kingdom)

The functional gene and three intronless pseudogenes for human triosephosphate isomerase were isolated from a recombinant DNA library and characterized in detail. The functional gene spans 3.5 kilobase...Full Text Available

1985-07-01

304

Characterization of discrete classes of binding sites of human serum albumin by application of thermodynamic principles.  

UK PubMed Central (United Kingdom)

The binding interactions of four ligands differing in acid-base properties with human serum albumin (HSA) were examined as a function of temperature. Binding to HSA decreased with increasing temperature...Full Text Available

1994-08-15

305

Characterization of Two Unique Cholesterol-Rich Lipid Particles Isolated from Human Atherosclerotic Lesions  

UK PubMed Central (United Kingdom)

The authors' laboratory, using histochemicalmethods, previously identified two types of cholesterol-containing lipid particles in the extracellular spaces of human atherosclerotic lesions, one particle...Full Text Available

1990-01-01

306

Characterisation of CYP3A gene subfamily expression in human gastrointestinal tissues.  

UK PubMed Central (United Kingdom)

The human CYP3A subfamily is of interest due to its multiplicity, activity toward known carcinogens, and extrahepatic expression. In situ hybridisation analysis of formalin fixed, routinely processed...Full Text Available

1995-02-01

307

Cadmium, Lead, and Other Metals in Relation to Semen Quality: Human Evidence for Molybdenum as a Male Reproductive Toxicant  

UK PubMed Central (United Kingdom)

BackgroundEvidence on human semen quality as it relates to exposure to various metals, both essential (e.g., zinc, copper) and nonessential (e.g., cadmium, lead), is inconsistent....Full Text Available

2008-11-01

308

Blood velocity measurement in human conjunctival vessels  

UK PubMed Central (United Kingdom)

The bulbar conjunctiva is one of the few areas in which blood flow in the peripheral vasculature can be directly and noninvasively observed in the human. Although extensive literature exists describing...Full Text Available

1981-12-01

309

BK Virus and Human Cancer: Innocent until Proven Guilty  

UK PubMed Central (United Kingdom)

BK virus (BKV) is a polyomavirus that ubiquitously infects the human population. Following a typically subclinical primary infection, BKV establishes a lifelong persistent infection in the kidney...Full Text Available

2009-08-01

310

Autocitrullination of human peptidyl arginine deiminase type 4 regulates protein citrullination during cell activation  

UK PubMed Central (United Kingdom)

ObjectiveTo address mechanisms that control the activity of human peptidyl arginine deiminase type 4 (PAD-4).MethodsFull Text Available

2010-06-01

311

Assessment of structural changes of human teeth by low-field nuclear magnetic resonance (NMR)  

UK PubMed Central (United Kingdom)

A technique of low-field pulsed proton nuclear magnetic resonance (NMR) spin relaxation is described for assessment of age-related structural changes (dentin and pulp) of human teeth in...Full Text Available

2010-01-01

312

Application of Cryopreserved Human Hepatocytes in Trichloroethylene Risk Assessment: Relative Disposition of Chloral Hydrate to Trichloroacetate and Trichloroethanol  

UK PubMed Central (United Kingdom)

BackgroundTrichloroethylene (TCE) is a suspected human carcinogen and a common ground-water contaminant. Chloral hydrate (CH) is the major metabolite of TCE formed in the liver by...Full Text Available

2006-08-01

313

Appearance of beta-endorphin-like immunoreactivity in human ventricular cerebrospinal fluid upon analgesic electrical stimulation.  

UK PubMed Central (United Kingdom)

beta-Endorphin-like immunoreactivity in human ventricular cerebrospinal fluid was measured with a specific radioimmunoassay. The subjects were undergoing a surgical procedure for relief of chronic intractable...Full Text Available

1978-10-01

314

Apoptosis of human seminoma cells upon disruption of their microenvironment.  

UK PubMed Central (United Kingdom)

One of the main obstacles encountered when trying to culture human seminoma (SE) cells in vitro is massive degeneration of the tumour cells. We investigated whether dissociation of tumour tissue, to...Full Text Available

1996-05-01

315

Antigenic analysis of the second extra-cellular loop of the human beta-adrenergic receptors.  

UK PubMed Central (United Kingdom)

Polyclonal antibodies were raised in rabbits by immunization with free peptides corresponding to positions 197-222 of the human beta 1-adrenergic receptor (beta 1 peptide) and the corresponding sequence...Full Text Available

1989-10-01

316

Anti-beta-endorphin immunoglobulin G in humans.  

UK PubMed Central (United Kingdom)

Human IgG specific for beta-endorphin was identified by enzyme-linked immunoabsorbent assay and isolated by affinity chromatography. From a sample of 27 subjects, three individuals with major depression...Full Text Available

1986-11-01

317

Angular distribution of environmental radiation incident on humans; and reply  

International Nuclear Information System (INIS)

A brief letter attempts to justify the assumption in an earlier paper of an isotropic distribution of environmental gamma rays incident on humans. A second letter from the original authors responds to this in yet more detail. (UK).

318

Actin-like sequences are present on human X and Y chromosomes.  

UK PubMed Central (United Kingdom)

The human genome contains greater than 20 actin-related sequences, six of which at least are expressed as protein. We have shown by blot hybridization the presence of actin-like sequences on both the...Full Text Available

1984-08-01

319

A semi-qualitative study of attitudes to vaccinating adolescents against human papillomavirus without parental consent  

UK PubMed Central (United Kingdom)

BackgroundThe first vaccine to prevent human papillomavirus (HPV) and cervical cancer has been licensed, and in future, vaccination may be routinely offered to 10–14 year...Full Text Available

320

A second origin of DNA plus-strand synthesis is required for optimal human immunodeficiency virus replication.  

UK PubMed Central (United Kingdom)

We recently reported that human immunodeficiency virus type 1 (HIV-1) unintegrated linear DNA displays a discontinuity in its plus strand, precisely defined by a second copy of the polypurine tract...Full Text Available

1992-05-01

321

A second generation human haplotype map of over 3.1 million SNPs  

UK PubMed Central (United Kingdom)

We describe the Phase II HapMap, which characterizes over 3.1 million human single nucleotide polymorphisms (SNPs) genotyped in 270 individuals from four geographically diverse populations and...Full Text Available

2007-10-18

322

A naturally occurring human antibody to loops of Henle  

UK PubMed Central (United Kingdom)

A hitherto unreported immunofluorescent staining pattern obtained from human sera is described. Serum from six patients was found to possess specific antibody activity against lining cells of loops...Full Text Available

1973-08-01

323

A genomic and proteomic investigation of the impact of preimplantation factor on human decidual cells  

UK PubMed Central (United Kingdom)

OBJECTIVEPreimplantation factor (PIF) is a novel, 15 amino acid peptide, secreted by viable embryos. This study aims to elucidate PIF’s effects in human endometrial...Full Text Available

2010-05-01

324

A gene expression signature shared by human mature oocytes and embryonic stem cells  

UK PubMed Central (United Kingdom)

BackgroundThe first week of human pre-embryo development is characterized by the induction of totipotency and then pluripotency. The understanding of this delicate process will have...Full Text Available

325

A Controlled Challenge Study on Di(2-ethylhexyl) Phthalate (DEHP) in House Dust and the Immune Response in Human Nasal Mucosa of Allergic Subjects  

UK PubMed Central (United Kingdom)

BackgroundFew studies have yet addressed the effects of di(2-ethylhexyl) phthalate (DEHP) in house dust on human nasal mucosa.ObjectivesWe investigated...Full Text Available

2008-11-01

326

45 CFR 1304.24 - Child mental health.  

Science.gov (United States)

... 2010-10-01 false Child mental health. 1304.24 Section 1304.24 Public...HUMAN DEVELOPMENT SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES THE ADMINISTRATION...AGENCIES Early Childhood Development and Health Services § 1304.24 Child...

2010-10-01

327

jahresbericht6.5NEU  

Wastenet

The industrial revolution changed the pattern of human interaction with nature profoundly.Not only did social metabolism

329

Significance of the Human Being as an Element in an ...  

Science.gov (United States)

... Montgomery's diversionary plan called Goodwood. The goal ... Montgomery's Operation Goodwood began with a huge air armada attack on German ...

2002-03-01

330

Release 01-93 - NASA Human Space Flight  

Science.gov (United States)

These cutting-edge developments will be used for future government and commercial launch systems and space transportation operations. ...

331

RAYMAN: A FORTRAN Computer Code for Tracing Rays ...  

Science.gov (United States)

... Descriptors : *COMPUTERIZED SIMULATION, *HUMAN BODY, *WOUND BALLISTICS, COMPUTER PROGRAMS, PROJECTILES, MATRICES ...

1977-11-01

332

Palo Verde control room human study: results  

International Nuclear Information System (INIS)

(1981). United States Guidetti, RP Luna, SF Rowland, JW Bechtel, Downey,

333

Palo Verde control room human factors study: methodology  

International Nuclear Information System (INIS)

(1981). United States Guidetti, RP Luna, SF Rowland, JW Bechtel, Downey,

334

Interpreting Mammalian Evolution using Fugu Genome Comparisons  

Energy Technology Data Exchange (ETDEWEB)

Comparative sequence analysis of the human and the pufferfish Fugu rubripes (fugu) genomes has revealed several novel functional coding and noncoding regions in the human genome. In particular, the fugu genome has been extremely valuable for identifying transcriptional regulatory elements in human loci harboring unusually high levels of evolutionary conservation to rodent genomes. In such regions, the large evolutionary distance between human and fishes provides an additional filter through which functional noncoding elements can be detected with high efficiency.

2004-04-02

336

Improved Usability of Locomotion Devices Using Human ...  

Science.gov (United States)

... increasing photorealism. Furthermore, developments in audio technology continue to increase the spatial awareness of users in VEs. ...

2009-03-01

337

Human Systems Center Products and Progress.  

Science.gov (United States)

... Page 43. Integrated Audio Technology Demonstrator The Integrated Audio Technology Dem- development for this application is successful. ...

1993-10-01

338

Human Auditory Localization Performance in Azimuth  

Science.gov (United States)

... The realization of directional audio technology in the cockpit may reduce visual workload, enhance the presentation of flight and threat information ...

1991-01-01

339

Effect of dietary constituents on the absorption of lead in the human  

International Nuclear Information System (INIS)

... biological effects body burden diet intestinal absorption lead lead 203 man

1983-03-01

342

Considerations in the Design and Development of a Human ...  

Science.gov (United States)

... appropriate. At press time, the laws governing the use of digital audio technology and the technology itself are rapidly changing. ...

1990-09-20

343

Circuitry for a Wireless Microsystem for Neural Recording ...  

Science.gov (United States)

... in artificial intelligence, human physiology and biomedical prosthesis. ... central and peripheral nerve systems [1 ... CMOS circuit interface for multiplexed ...

2001-10-25

344

Chromosomal localization and cDNA sequence of human BTEB, a GC box binding protein  

Energy Technology Data Exchange (ETDEWEB)

Human BTEB cDNA clones have been isolated, sequenced, and the corresponding gene has been assigned to human chromosome 9, region q13, by fluorescent in situ hybridization and DNA blot analysis using DNAs from hybrid cell clones containing a single human chromosome. The cDNA clone encodes a polypeptide of 244 amino acids whose sequence shows a high sequence similarity with the rat BTEB (98% amino acid identity).

1993-09-01

345

Chromosomal damage in human lymphocytes from radio-isotope therapy  

International Nuclear Information System (INIS)

(Dec 1973). United Kingdom Stevenson, AC Medical Research Council, Oxford

346

Aliens in Antarctica - GCMD - NASA  

Science.gov (United States)

International Polar Year (IPY) Aliens in Antarctica will assess the threat of humans carrying non-native seeds and spores into Antarctica. ...

348

Accommodation, Acuity, and their Relationship to Emmetropization in Infants  

UK PubMed Central (United Kingdom)

PurposeTo evaluate the relationship between accommodation, visual acuity, and emmetropization in human infancy.MethodsFull Text Available

2009-06-01

349

27 - NASA  

Science.gov (United States)

02.10.10 - NASA and Texas Instruments are using the theme of human space exploration to develop digital libraries of math and science problems for high ...

350

Urban Atmospheric Science  

Environmental Research Database

DescriptionThis new research programme activity on Urban Atmospheric Science will deliver aspects of the NERC strategy: Next Generation Science for Planet Earth. It has been developed as part of the Environment, Pollution & Human Health theme. Research in the Environment, Pollution & Human Health theme is directed at elucidating key environmental processes that form part of a causal pathway between an environmental hazard and disease outcome, and providing a predictive capability of the risk to human heal [continued...

2012-01-01

351

The human U1-70K snRNP protein: cDNA cloning, chromosomal localization, expression, alternative splicing and RNA-binding.  

UK PubMed Central (United Kingdom)

We have isolated and sequenced cDNA clones encoding the human U1-70K snRNP protein, and have mapped this locus (U1AP1) to human chromosome 19. The gene produces two size classes of RNA, a major 1.7-kb...Full Text Available

1987-12-23

352

Synthesis and cloning of the genes of antisense peptides of human calcitonin and miniproinsulin  

Energy Technology Data Exchange (ETDEWEB)

With the aim of an experimental check on the validity of the theory of molecular recognition, the authors have carried out the chemical-enzymatic synthesis and cloning of the gene of human calcitonin and also of the genes of antisense polypeptides to human calcitonin and miniproinsulin. It has been shown that recombinant plasmids obtained on the basis of these synthetic genes are capable of ensuring the biosynthesis of the given polypeptides in E. coli cells as hybrid proteins with the IgG-binding domain of staphylococcal protein A.

1994-07-20

353

Long-Term Specific Immune Responses Induced in Humans by a Human Immunodeficiency Virus Type 1 Lipopeptide Vaccine: Characterization of CD8+-T-Cell Epitopes Recognized  

UK PubMed Central (United Kingdom)

We studied the effect of booster injections and the long-term immune response after injections of an anti-human immunodeficiency virus type 1 (HIV-1) lipopeptide vaccine. This vaccine was injected alone...Full Text Available

2003-10-01

354

Human thrombomodulin gene is intron depleted: nucleic acid sequences of the cDNA and gene predict protein structure and suggest sites of regulatory control.  

UK PubMed Central (United Kingdom)

We have isolated a human thrombomodulin cDNA, and a human genomic clone containing the putative promoter domain, as well as the translated and untranslated regions of the endothelial cell receptor....Full Text Available

1987-09-01

355

Human error and experienced feedback during refuelling overhauling of Daya Bay Nuclear Power Station  

International Nuclear Information System (INIS)

The authors describe the various human error encountered during Daya bay refueling overhaul, and the subsequent root cause evaluation and protective measure. Authors consider transparency is the key in reducing human error and event recurrence. Additional y, event transparency will enhance the effectiveness if experience feedback and reduce event consequence

2000-10-01

356

Contribution to the in vitro multielement X-ray fluorescence analysis of human soft tissues  

International Nuclear Information System (INIS)

Determination of Mn, Fe, Ni, Cu, Zn, and Pb in human soft tissues by radionuclide X-ray fluorescence analysis (using "2"3"8Pu and "1"0"9Cd sources) is described. The results of multielement XRS analysis of selected human tissues are tabulated. They are in good agreement with the literature data. It is concluded that X-ray fluorescence technique is a suitable method for trace element determination. (author).

1986-11-01

357

Chimeric Matrix Proteins Encoded by Defective Proviruses with Large Internal Deletions in Human T-Cell Leukemia Virus Type 1-Infected Humans  

UK PubMed Central (United Kingdom)

Human T-cell leukemia virus type 1 (HTLV-1) is the etiologic agent of adult T-cell leukemia/lymphoma (ATLL), HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), and other diseases....Full Text Available

2000-05-01

358

Cause trending analysis for licensing operational events in Daya Bay Nuclear Power Station  

International Nuclear Information System (INIS)

The human causal factors for all human error licensing operational events on Daya Bay nuclear power station since 1993 to 2003 are categorized, the trend of these causal factors is analyzed. The emphasis is placed on analyzing the deficiencies on complying with and executing regulations and procedures. The results provide directional reference for nuclear power station to improve human performance. (author)

2005-09-01

359

Analysis of the murine All-1 gene reveals conserved domains with human ALL-1 and identifies a motif shared with DNA methyltransferases.  

UK PubMed Central (United Kingdom)

A series of translocation break points found in a subset of human acute leukemias have one of the breaks on human chromosome 11q23. This region has recently been cloned and a large gene, ALL-1, with...Full Text Available

1993-07-01

360

Activation of Metallothioneins and ?-Crystallin/sHSPs in Human Lens Epithelial Cells by Specific Metals and the Metal Content of Aging Clear Human Lenses  

UK PubMed Central (United Kingdom)

PurposeTo identify those metallothionein and α-crystallin/small heat-shock genes induced by toxic metals in human lens cells and to evaluate...Full Text Available

2003-02-01

361

A single-stranded gap in human immunodeficiency virus unintegrated linear DNA defined by a central copy of the polypurine tract.  

UK PubMed Central (United Kingdom)

The structure of unintegrated human immunodeficiency virus type 1 (HIV-1) DNA from acutely infected human lymphoid cells was analyzed by nuclease S1 cleavage. We observed a unique, discrete single-stranded...Full Text Available

1991-05-01

362

A Human Reliability Analysis of Pre-Accident Human Errors in the Low Power and Shutdown PSA of the KSNP  

International Nuclear Information System (INIS)

Korea Atomic Energy Research Institute, using the ANS Low Power /Shutdown (LPSD)PRA Standard, evaluated the LPSD PSA model of the KSNP, Younggwang (YGN) Units 5 and 6, and identified the items to be improved. The evaluation results of human reliability analysis (HRA) of the pre-accident human errors in the LPSD PSA model of the KSNP showed that 13 items among 15 items of supporting requirements for those in the ANS PRA Standard were identified as them to be improved. Thus, we newly carried out a HRA for pre-accident human errors in the LPSD PSA model for the KSNP to improve its quality. We considered potential pre-accident human errors for all manual valves and control/instrumentation equipment of the systems modeled in the KSNP LPSD PSA model except reactor protection system/ engineering safety features actuation system. We reviewed 160 manual valves and 56 control/instrumentation equipment. The number ...

2003-04-20

363

Turgor-regulated sugar release in sugarbeet leaves  

Energy Technology Data Exchange (ETDEWEB)

Under drought conditions, sucrose distribution (osmotic adjustment vs. export) may be regulated at the mesophyll plasmalemma/tonoplast. Leaves were given {sup 14}CO{sub 2} for a 30/30 min pulse/chase. Peeled leaf discs were put in low or high osmotic solutions to monitor release of labeled solutes. High turgor increased efflux rates double those at low turgor. About 30% and 55% of the released label was in the sugar (sucrose + hexose) fractions at low and high turgor, respectively. Response to changes in cell turgor was rapid and reversible. PCMBS had no effect on efflux. NEM and CCCP enhanced efflux at high turgor. Presence of unlabeled sucrose in the wash solutions greatly enhanced sucrose efflux in a turgor-dependent manner; suggesting the presence of a sucrose exchange system, which appeared to be at the tonoplast. Turgor-regulated efflux involved both the tonoplast and plasmalemma. However, efflux across the plasmalemma was not carrier-mediated.

1989-04-01

364

Serviceability of steam generators at NPPs with reactors of the WWER-440 and WWER-1000 types  

Energy Technology Data Exchange (ETDEWEB)

Steam generators (SG) are the weak link of nuclear power plants, their service life is shorter than the service life of other NPP components. This paper is dedicated to a statistical analysis of SG damages and failures. Heat exchanging tubes (HET) are the most damaged elements in SG, there are on average 286 plugged or repaired tubes in each operating SG. The usually mechanisms of tube failure are the following: denting, corrosion at tube outside, pitting, fretting, and circular crack propagation. Most of damages are located in the transition zone above a tube plate. This study shows that the factors that are involved in the SG HET fault probability are: - design features of SG and secondary equipment elements (high pressure feed heaters (HPFH), low pressure feed heater (LPFH)), - water chemistry at different points of condensate feed pipe, composition and density of deposits on HET surface, efficiency of mechanical and chemical washing, - the physical and chemical ...

2002-07-01

365

Remediation process technology for ground water  

Energy Technology Data Exchange (ETDEWEB)

The operation of industrial facilities has generally resulted in contamination of the surrounding soils and ground water. A variety of methods have been proposed for the remediation of contaminated sites. This paper presents new process technology that is capable of performing treatment on ground water or soil washing leachates. The process is targeted to treat low levels of radioactivity, organics and heavy metals present in the aqueous solutions, to be easily transported and provide simple operation on-site and provide an effluent that meets the specified discharge quality. The purification process involves sequential chemical treatment and filtration. The paper will describe the development of the technology and review the current progress in its use to remediate contaminated sites at Chalk River. The application of the process technology has demonstrated that the ambitious goal of setting the effluent targets to meet the drinking water standards was realized. A ...

1993-12-31

366

Remediation process technology for ground water  

International Nuclear Information System (INIS)

The operation of industrial facilities has generally resulted in contamination of the surrounding soils and ground water. A variety of methods have been proposed for the remediation of contaminated sites. This paper presents new process technology that is capable of performing treatment on ground water or soil washing leachates. The process is targeted to treat low levels of radioactivity, organics and heavy metals present in the aqueous solutions, to be easily transported and provide simple operation on-site and provide an effluent that meets the specified discharge quality. The purification process involves sequential chemical treatment and filtration. The paper will describe the development of the technology and review the current progress in its use to remediate contaminated sites at Chalk River. The application of the process technology has demonstrated that the ambitious goal of setting the effluent targets to meet the drinking water standards was realized. A ...

1993-09-05

367

Regeneration of filaments (colonies) from Anabaena variabilis spheroplasts  

Energy Technology Data Exchange (ETDEWEB)

A simple method for regeneration of filaments (clones) from spheroplasts of the cyanobacterium (blue-green alga), Anabaena variabilis, was developed and used to quantify cell growth in the presence of two antibiotics. Cells from exponential phase cultures of ATCC 29413 and M3 were harvested and incubated with lysozyme (0.12% in 0.03M K-phosphate, pH 6.8, 0.55M sorbitol; 37 C) to produce spheroplasts. The spheroplasts were washed with buffer, plated onto soft agar and incubated (18 h light: 6 hr dark, 27 C). Colonies became visible at 7 - 9 days and were monitored for times up to 21 days. The concentration of chloramphenicol which inhibited cell growth by 50% was approximately 1.8 mg ml/sup -1/ medium and the concentrations of ampicillin which inhibited cell growth by 50% were approximately 4 and 15 pg ml/sup -1/ medium for ATCC 29413 and M3, respectively. This method may be useful for genetic manipulation of cells from these and other filamentous, N/sub 2/-fixing ...

1986-04-01

368

Performance of bentonite/crushed rock borehole plugs  

International Nuclear Information System (INIS)

A mixture of crushed rock and bentonite is being considered as backfill and sealant for high-level nuclear waste repositories. Many variables affect the hydraulic conductivity of such a mixture, including the size and shape of the rock particles, method of mixing, water content and density of the clay, and the weight ratio of rock to clay. Mixtures of crushed basalt and bentonite have been tested to determine the relative effects of these variables. Two types of permeameters are used, 20 cm diameter stainless steel permeameters and 10 cm diameter clear PVC permeameters. Plugs are installed as a single lift or in many lifts; the water content of the clay ranged from air-dry (in most cases) to as high as 200%. Preliminary results show that a mixture of 75% crushed basalt and 25% bentonite has a hydraulic conductivity between 1 x 10/sup -9/ cm/s and 2.5 x 10/sup -8/ cm/s. In some cases, preferential flow paths have developed (possibly as a result of the montmorillonite ...

369

Mine waste disposal and managements  

Energy Technology Data Exchange (ETDEWEB)

Acid Rock Drainage (ARD) is the product formed by the atmospheric oxidation of the relatively common pyrite and pyrrhotite. Waste rock dumps and tailings containing sulfide mineral have been reported at toxic materials producing ARD. Mining in sulphide bearing rock is one of activity which may lead to generation and release of ARD. ARD has had some major detrimental affects on mining areas. The purpose of this study was carried out to develop disposal method for preventing contamination of water and soil environment by waste rocks dump and tailings, which could discharge the acid drainage with high level of metals. Scope of this study was as following: environmental impacts by mine wastes, geochemical characteristics such as metal speciation, acid potential and paste pH of mine wastes, interpretation of occurrence of ARD underneath tailings impoundment, analysis of slope stability of tailings dam etc. The following procedures were used as part of ARD evaluation and prediction to ...

1998-12-01

370

Manufacturing method of metal-hydrogen alkali storage battery. Kinzoku-suiso alkali chikudenchi no seizo hoho  

Energy Technology Data Exchange (ETDEWEB)

This invention is a manufacturing method of a metal-hydrogen alkali battery cell consisting of a positive electrode of metal oxides, alkaline electrolyte solution and a separator containing an amide-radical, wherein the above treating solution is aqueous solution of KOH (or NaOH) which is heated at least at 40 centigrade and the separator is first immersiion-treated and then water-washed and dried. The amide-radical-containing separaator uses a nylon non-woven fabrics. Average molecular weight of nylon 66 is 12,000 - 20,000. In this invention, in order to improve the storage ability and the cycle characteristics which are caused by corrosion of a separator which takes place in the cell after its assembly, the separator is immersed in a hot alkali in order to obtain a non-woven fabric of nylon 66 consisting of alkali-stable high molecular weight portion, which is assembled into a battery. By this, the dissolving of the non-woven fabric and the generation of ammonia ...

1989-12-20

371

Framework for managing wastes from oil and gas exploration and production (E&P) sites.  

Energy Technology Data Exchange (ETDEWEB)

Oil and gas companies operate in many countries around the world. Their exploration and production (E&P) operations generate many kinds of waste that must be carefully and appropriately managed. Some of these wastes are inherently part of the E&P process; examples are drilling wastes and produced water. Other wastes are generic industrial wastes that are not unique to E&P activities, such as painting wastes and scrap metal. Still other wastes are associated with the presence of workers at the site; these include trash, food waste, and laundry wash water. In some host countries, mature environmental regulatory programs are in place that provide for various waste management options on the basis of the characteristics of the wastes and the environmental settings of the sites. In other countries, the waste management requirements and authorized options are stringent, even though the infrastructure to meet the requirements may not be available ...

2007-09-15

372

Film ispalators  

International Nuclear Information System (INIS)

New physical objects, ispalators based on free soap films, exhibit persistent flows of the soap solution in open and closed volumes in air with additions of gases of the C_8F_1_8 type (p = 20 Torr) at temperature drops on the films of the order of tenths and hundredths of kelvin. The flows move continuously at a velocity of 5 - 20 cm s"-"1. It is found that the parts of an inclined ispalator film show anomalous behaviour upon heating: their weight increases and they move downward over the film, whereas the unheated parts of the film move upward. Continuous radial vortex flows accompanied by the formation and washing of the regions of a thin black film are observed on circular films in closed volumes upon their uniform external cooling by evaporating water for 5 - 10 hours. The rapid flows make film ispalators the efficient heat carriers, which operate at small temperature drops (tenths and hundredths of kelvin) and surpass copper in the amount of thermal energy ...

2002-05-31

373

Fast Flux Test Facility (FFTF) standby plan  

Energy Technology Data Exchange (ETDEWEB)

The FFTF Standby Plan, Revision 0, provides changes to the major elements and project baselines to maintain the FFTF plant in a standby condition and to continue washing sodium from irradiated reactor fuel. The Plan is consistent with the Memorandum of Decision approved by the Secretary of Energy on January 17, 1997, which directed that FFTF be maintained in a standby condition to permit the Department to make a decision on whether the facility should play a future role in the Department of Energy`s dual track tritium production strategy. This decision would be made in parallel with the intended December 1998 decision on the selection of the primary, long- term source of tritium. This also allows the Department to review the economic and technical feasibility of using the FFTF to produce isotopes for the medical community. Formal direction has been received from DOE-RL and Fluor 2020 Daniel Hanford to implement the FFTF standby decision. The objective of the Plan ...

1997-03-06

374

Factors determining the stainless steel decontamination efficiency for the steam generator heat exchanger tubes at NPPs with the WWERs  

International Nuclear Information System (INIS)

To raise the efficiency of the redox method and decrease the amount of radioactive wastes, a possibility of improving the decontamination process for NPP heat exchanger tubes made of stainless steel is studied. In the home practice the redox method of equipment decontamination is carried out as a multi-cycle process. In each cycle the surface is treated first with a permanganate alkaline solution ther with an oxalic acid solution, with a condensate washing-at between the treatments. Using samples cut out of the steam generator pipelines of the first and third power units of the Novovoronezh NPP the effect of the oXalic acid concentration, as well as washout time and conditions on the decontamination factor are studied. On the basis of analysis of the obtained data a conclusion is drawn that using oxalic acid of low concentrations and increasing its concentrations from cycle to cycle maximum decontamination factor values can be obtained at a minimum salt content in ...

375

Extrusion as a thermo-mechanical pre-treatment for lignocellulosic ethanol  

Energy Technology Data Exchange (ETDEWEB)

Two physical pre-treatment methods, particle size reduction by grinding and thermo-mechanical extrusion, were evaluated as alternatives to traditional biomass pretreatments for lignocellulosic ethanol. Commonly available agricultural co-products wheat bran and soybean hull were the model substrates. Extrusion led to higher reducing sugar yields as compared to grinding for wheat bran, but not in the case of soybean hulls. The best combination of extrusion screw speed and maximum barrel temperature were 7 Hz/150 C and 3.7 Hz/110 C. The use of a solvent mixture (sodium hydroxide, urea, and thiourea) and calcium chloride solution in combination with extrusion treatment did not lead to improvement in reducing sugar yield. However, extensive washing to get rid of solvents and enzymatic inhibitors improved the conversion efficiency substantially, resulting in total reducing sugar yields of 60-73% and 25-36%, respectively, for wheat bran and soybean hull. (author)

2010-12-15

376

Eliminating incrusted solids in drinking water conduits in Cantillana, Seville, Spain; Eliminacion de los solidos incrustados en las conducciones de agua potable de Cantillana (Sevilla)  

Energy Technology Data Exchange (ETDEWEB)

The presence of iron and manganese in underground water due to rock leaching may cause problems in drinking water. the oxidation of these metals produces precipitates which alter water quality (by making it cloudy and bad testing) and may even block supply pipes. This article presents a way eliminating this problem which was tried out in the conduits of Cantillana, a municipality in the province of Seville, Spain. Cleaning the pipes with a mixture of H{sub 2}O{sub 2} + water changes the characteristics of the deposits from flocculant and absorbent to sandy following which they are washed away by the pressure of the water. Once the pipes have been cleaned, a minimal amount of maintenance will prevent the formation of new deposits. This article thus a relatively simple and economical solution for recovering water quality as an alternative to the complicated replacement of the whole network. (Author) 7 refs.

1998-12-01

377

Effects of paraquat on Escherichia coli: Differences between B and K-12 strains  

Energy Technology Data Exchange (ETDEWEB)

Escherichia coli B and K-12 are equally susceptible to the bacteriostatic effects of aerobic paraquat, but they differed strikingly when the lethality of paraquat was evaluated. E. coli B suffered an apparent loss of viability when briefly exposed to paraquat, whereas E. coli K-12 did not. This difference depended on the ability of the B-strain, but not the K-12 strain, to retain internalized paraquat; the B strain was killed on aerobic tryptic soy-yeast extract plates during the incubation which preceded the counting of colonies. This difference in retention of paraquat between strains was demonstrated by delayed loss of viability, by growth inhibition, and by cyanide-resistant respiration after brief exposure to paraquat, washing, and testing in fresh medium. This difference was also shown by using ({sup 14}C)paraquat. This previously unrecognized difference between E. coli B and K-12 has been the cause of apparently contradictory reports and should lead to some ...

1990-02-01

378

Effect of fiber treatments on tensile and thermal properties of starch/ethylene vinyl alcohol copolymers/coir biocomposites.  

Science.gov (United States)

Coir fibers received three treatments, namely washing with water, alkali treatment (mercerization) and bleaching. Treated fibers were incorporated in starch/ethylene vinyl alcohol copolymers (EVOH) blends. Mechanical and thermal properties of starch/EVOH/coir biocomposites were evaluated. Fiber morphology and the fiber/matrix interface were further characterized by scanning electron microscopy (SEM). All treatments produced surface modifications and improved the thermal stability of the fibers and consequently of the composites. The best results were obtained for mercerized fibers where the tensile strength was increased by about 53% as compared to the composites with untreated fibers, and about 33.3% as compared to the composites without fibers. The mercerization improved fiber-matrix adhesion, allowing an efficient stress transfer from the matrix to the fibers. The increased adhesion between fiber and matrix was also observed by SEM. Treatment with water also ...

2009-06-26

379

Different purification methods and quality of sunflower biodiesel  

Energy Technology Data Exchange (ETDEWEB)

Biodiesel is derived from triacylglycerides and is produced primarily through transesterification, a chemical reaction of vegetable oils with alcohol, methanol or ethanol. The cost of raw material should be considered since 85 per cent of production cost is related to vegetable oil. The purpose of this study was to evaluate oil expression of sunflower seed. It also examined the sunflower crude oil as a raw material for biodiesel by transesterification in both laboratory and pilot scale studies. Three different biodiesel purification methods were examined. The best result for oil expelling (68.4 per cent) at the experimental stage was obtained for seeds with a moisture content of 6.9 per cent at 25 degrees C and at a screw speed of 114 rpm. For biodiesel production at the laboratory scale, the best result for oil expelling was 87.5 per cent. It was obtained with an ethanol:oil molar ratio of 4.7:1 and with a 4.42 per cent catalyst concentration related to the quantity of oil that had to ...

2010-07-01

380

Development of a new evaporator using hydrophobic membrane for radioactive liquid waste  

Energy Technology Data Exchange (ETDEWEB)

An evaporator using a hydrophobic membrane made from a polytetrafluoroethylene (PTFE) was developed to improve DF (Decontamination Factor) and to reduce evaporator size. The membrane distillation, provided by the evaporator, is a new technique for liquid purification. Fundamental experiments were carried out to develop the membrane filter (tube type, outer diameter, 8 mm; membrane thickness, 500 {mu}m) for radioactive liquid treatment. The continuous operation test using actual liquid waste was also made during about 3,000 h. (This is almost equal to the operation time of an actual evaporator per year.) The evaporation rate decreased with increase an operation time due to contamination of waste impurity. But the rate was recovered by washing the membrane with hot water and then drying it. DF was over 10{sup 4} which is ten times larger than that for a conventional system. A pilot plant (capacity, 200 kg-liquid waste/h) was constructed and its performance test was ...

1996-10-01

381

Biogeochemical cycling of N in tropical coastal zones: molecular microbial ecology of trace gas production.  

Environmental Research Database

ObjectivesThe specific objectives of the research are to: 1. Determine the concentrations of N2O, NO and NO2 in tropical coastal waters in relation to nutrients and salinities. 2. Determine, with excess nitrate present, the potential for nitrate reduction and denitrification in sediments along tropical estuaries, and whether NO, NO2, N2O, N2 or NH4+ are significant products. 3. Establish the balance between denitrification, nitrate ammonification and anammox in tropical estuarine sediments, relative to [continued...]DescriptionThe coastal zone is extremely important in the biogeochemical processes which control the natural cycle of elements of the Earth. In particular, the coastal zone contributes significantly to the nitrogen cycle, removing nitrogen washed in from the land by rivers and so reducing its fertilizing impact on the coastal seas. However, these removal processes, driven by microorganisms, also contribute to the formation of nitrogen gases, some of ...

2009-01-31

382

Baryon history and cosmic star formation in non-Gaussian cosmological models: numerical simulations  

British Library Electronic Table of Contents (United Kingdom)

Abstract We present the first numerical,-N-body, hydrodynamical, chemical simulations of cosmic structure formation in the framework of non-Gaussian models. We study the impact of primordial non-Gaussianities on early chemistry (e-, H, H+, H-, He, He+, He++, H2, H+2, D, D+, HD, HeH+), molecular and atomic gas cooling, star formation, metal (C, O, Si, Fe, Mg, S) enrichment, Population-III (popIII) and Population-II-I (popII) transition and on the evolution of -visible- objects. We find that non-Gaussianities can have some consequences on baryonic structure formation at very early epochs, but the subsequent evolution at later times washes out any difference among the various models. When assuming reasonable values for primordial non-Gaussian perturbations, it turns out that they are responsi...

2011-01-01

383

Are HI Supershells the Remnants of $\\gamma$-Ray Bursts?  

CERN Document Server

Gamma-Ray Bursts (GRBs) are thought to originate at cosmological distances from the most powerful explosions in the Universe. If GRBs are not beamed then the distribution of their number as a function of gamma-ray flux implies that they occur once per (0.3-40) million years per bright galaxy and that they deposit >10^{53} ergs into their surrounding interstellar medium. The blast wave generated by a GRB explosion would be washed out by interstellar turbulence only after tens of millions of years when it finally slows down to a velocity of 10 km/s. This rather long lifetime implies that there could be up to several tens of active GRB remnants in each galaxy at any given time. For many years, radio observations have revealed the enigmatic presence of expanding neutral-hydrogen (HI) supershells of kpc radius in the Milky Way and in other nearby galaxies. The properties of some supershells cannot be easily explained in terms of conventional sources such as stellar ...

1998-01-01

384

Analysis of myocardial time-activity curves of /sup 123/I-heptadecanoic acid. Pt. 1. Curve fitting  

Energy Technology Data Exchange (ETDEWEB)

Myocardial time-activity curves can be described by two or more parameters. To establish the optimal curve fitting method 33 myocardial time-activity curves were analyzed with different curve fitting methods: monoexponential, biexponential and monoexponential plus constant. A background correction was not applied. Biexponential curve fitting resulted in redundancy of parameters. Optimal curve fitting was obtained with monoexponential plus constant. The constant represents the background activity together with the stores radiolabelled lipids and the half-time value represents the wash-out of radioiodide from the myocardium. A strong relation was found between the constant and the half-time value: small errors in the determination of the constant (background activity) resulted in considerable errors of the half-time value. It is concluded that optimal analysis of a myocardial time-activity curve can be performed with a monoexponential plus constant without earlier ...

1987-12-01

385

Advanced coal liquefaction research: Technical progress report, October 1, 1986-December 31, 1986  

Energy Technology Data Exchange (ETDEWEB)

This report describes studies made during the fourth quarter of 1986 using the revised microautoclave experimental technique. Studies were made of the effect of reaction time on conversion using Kemmerer coal. Results that, at least during the first 30 minutes, conversion is a monotonically increasing function of reaction time and temperature. A study was also made of the effect of temperature on conversion. In general, conversion increased with temperature. The reactivity of coal appears to be unaffected by exposure to Certigrav fluid, if the exposed coal is subjected to two acetone washings under a nitrogen blanket. Work was started on using SCR-II process solvent in place of tetralin. Results indicate that SRC-II process solvent is a satisfactory solvent donor for high reactivity, high ash bituminous coals, but slightly less effective for low ash, subbituminous coals. Some tests were made to examine the effect of operating the Soxlett extraction equipment at ...

1988-03-01

386

Specificity of the human proteoglycan radioimmunoassay  

Energy Technology Data Exchange (ETDEWEB)

The human articular cartilagineous proteoglycans (PG) R.I.A. is highly specific. The PG used as the standard and the /sup 125/I labelled molecule appear to be pure. Under these conditions, all the potential interfering substances which have been tested show no cross reaction. For instance, the Ag-Ab equilibrium is not affected by adding human IgG, human albumin, hyaluronic acid, chondroitin sulfate, rat type II collagen or total human serum proteins. This R.I.A. also exhibits a species spcificity since there is no cross reaction with rat PG and negligible cross section with dog PG. The results obtained after addition of enzymes to the antigen demonstrate that the antigenic sites are localized on the protein region and not on the glycosaminoglycan region of the molecule.

1981-01-01

387

Investigating the biological and clinical significance of human dysbioses  

British Library Electronic Table of Contents (United Kingdom)

Culture-independent microbiological technologies that interrogate complex microbial populations without prior axenic culture, coupled with high-throughput DNA sequencing, have revolutionized the scale, speed and economics of microbial ecological studies. Their application to the medical realm has led to a highly productive merger of clinical, experimental and environmental microbiology. The functional roles played by members of the human microbiota are being actively explored through experimental manipulation of animal model systems and studies of human populations. In concert, these studies have appreciably expanded our understanding of the composition and dynamics of human-associated microbial communities (microbiota). Of note, several human diseases have been linked to alterations in th...

2011-01-01

388

Human reliability analysis in Wolsung 2/3/4 nuclear power plants probabilistic safety assessment  

Energy Technology Data Exchange (ETDEWEB)

The Level 1 probabilistic safety assessment (PSA) for Wolsung(WS) 2/3/4 nuclear power plant (NPPs) in design stage is performed using the methodologies being equivalent to PWR PSA. Accident sequence evaluation program (ASEP) human reliability analysis (HRA) procedure and technique for human error rate prediction (THERR) are used in HRA of WS 2/3/4 NPPs PSA. The= purpose of this paper is to introduce the procedure and methodology of HRA in WS 2/3/4 NPPs PSA. Also, this paper describes the interim results of importance analysis for human actions modeled in WS 2/3/4 PSA and the findings and recommendations of administrative control of secondary control area from the view of human factors. (Author) 10 refs., 2 tabs.

1997-05-01

389

Human reliability analysis in Wolsong 2/3/4 nuclear power plants probabilistic safety assessment  

International Nuclear Information System (INIS)

The Level 1 probabilistic safety assessment (PSA) for Wolsong(WS) 2/3/4 nuclear power plant(NPPs) in design stage is performed using the methodologies being equivalent to PWR PSA. Accident sequence evaluation program (ASEF) human reliability analysis (HRA) procedure and technique for human error rate prediction (THERP) are used in HRA of WS 2/3/4 NPPs PSA. The purpose of this paper is to introduce the procedure and methodology of HRA in WS 2/3/4 NPPs PSA. Also, this paper describes the interim results of importance analysis for human actions modeled in WS 2/3/4 PSA and the findings and recommendations of administrative control of secondary control area from the view of human factors.

1997-05-01

390

Field test studies of our infrared-based human temperature screening system embedded with a parallel measurement approach  

British Library Electronic Table of Contents (United Kingdom)

This paper introduces a parallel measurement approach for fast infrared-based human temperature screening suitable for use in a large public area. Our key idea is based on the combination of simple image processing algorithms, infrared technology, and human flow management. With this multidisciplinary concept, we arrange as many people as possible in a two-dimensional space in front of a thermal imaging camera and then highlight all human facial areas through simple image filtering, image morphological, and particle analysis processes. In this way, an individual's face in live thermal image can be located and the maximum facial skin temperature can be monitored and displayed. Our experiment shows a measured 1ms processing time in highlighting all human face areas. With a thermal imaging ca...

2009-01-01

391

Cloning of the cDNA and gene for a human D sub 2 dopamine receptor  

Energy Technology Data Exchange (ETDEWEB)

A clone encoding a human D{sub 2} dopamine receptor was isolated from a pituitary cDNA library and sequenced. The deduced protein sequence is 96% identical with that of the cloned rat receptor with one major difference: the human receptor contains an additional 29 amino acids in its putative third cytoplasmic loop. Southern blotting demonstrated the presence of only one human D{sub 2} receptor gene. Two overlapping phage containing the gene were isolated and characterized. DNA sequence analysis of these clones showed that the coding sequence is interrupted by six introns and that the additional amino acids present in the human pituitary receptor are encoded by a single exon of 87 base pairs. The involvement of this sequence in alternative splicing and its biological significance are discussed.

1989-12-01

392

Cause analysis and preventives for human error events in Daya Bay NPP  

International Nuclear Information System (INIS)

Daya Bay Nuclear Power Plant is put into commercial operation in 1994 Until 1996, there are 368 human error events in operating and maintenance area, occupying 39% of total events. These events occurred mainly in the processes of maintenance, test equipment isolation and system on-line, in particular in refuelling and maintenance. The author analyses root causes for human errorievents, which are mainly operator omission or error procedure deficiency; procedure not followed; lack of training; communication failures; work management inadequacy. The protective measures and treatment principle for human error events are also discussed, and several examples applying them are given. Finally, it is put forward that key to prevent human error event lies in the coordination and management, person in charge of work, and good work habits of staffs.

393

A novel glioblastoma cancer gene therapy using AAV-mediated long-term expression of human TERT C-terminal polypeptide  

British Library Electronic Table of Contents (United Kingdom)

Glioblastoma multiforme is the most aggressive form of human brain tumor, which has no effective cure. Previously, we have demonstrated that overexpression of the C-terminal fragment of the human telomerase reverse transcriptase (hTERTC27) inhibits the growth and tumorigenicity of human cervical cancer HeLa cells. In this study, the therapeutic effect and molecular mechanisms of hTERTC27-mediated cancer gene therapy were further explored in vivo in established human glioblastoma xenografts in nude mice. We showed that intratumoral injection of adeno-associated virus carrying hTERTC27 (rAAV-hTERTC27) is highly effective in reducing the growth of the subcutaneously transplanted glioblastoma tumors. Histological analyses showed that rAAV-hTERTC27 treatment leads to profound necrosis, apoptosi...

2007-01-01

394

Animal and human studies of a new /sup 99m/Tc labelled phosphine-isocyanide complex with possible applications to radionuclide ventriculography  

Energy Technology Data Exchange (ETDEWEB)

A new /sup 99m/Tc-phosphine-isocyanide complex with the general structure (/sup 99m/Tc (DEPE)/sub 2/(CNR)/sub 2/)/sup +/ has been synthesised and tested in animals and one human. In three animal species (rat, rabbit, dog), the complex is an efficient myocardial imaging agent, while in humans it remains in the blood pool. The complex is 100% protein bound in animals and humans, but whereas in humans it is attached to a 51.5 kdalton protein (probably prealbumin), in rabbits it appears to be bound to a larger macromolecule (M.W.>100 kdalton). The efficiency of the complex for blood pool labelling was tested in a human volunteer and compared with the standard in vivo red cell labelling technique with stannous pyrophosphate. A satisfactory radionuclide angiogram could be performed with less than 370 MBq of the complex. The count rate for the complex (cps/MBq) was 15% higher than that ...

1987-04-01

395

Integrated design environment for human performance and human reliability analysis  

Energy Technology Data Exchange (ETDEWEB)

Work over the last few years at the Idaho National Engineering and Environmental Laboratory (INEEL) has included a major focus on applying human performance and human reliability knowledge and methods as an integral element of system design and development. This work has been pursued in programs in a wide variety of technical domains, beginning with nuclear power plant operations. Since the mid-1980`s the laboratory has transferred the methods and tools developed in the nuclear domain to military weapons systems and aircraft, offshore oil and shipping operations, and commercial aviation operations and aircraft design. Through these diverse applications the laboratory has developed an integrated approach and framework for application of human performance analysis, human reliability analysis (HRA), operational data analysis, and simulation studies of human performance to the design ...

1997-05-01

396

A Human reliability analysis of post-accident human errors in the PSA of KSNP  

International Nuclear Information System (INIS)

Korea Atomic Energy Research Institute, using the ASME PRA Standard, evaluated the PSA model of the Korea Standard Nuclear Power Plant (KSNP) and identified the items to be improved to enhance its quality. The new risk monitor PSA model for the KSNP of which quality was enhanced is called as PRiME-U3i. The evaluation results of human reliability analysis (HRA) of the post-accident human errors in the PSA model of the KSNP showed that 10 items among 19 items of supporting requirements for those in the ASME PRA Standard were identified as them to be improved. Thus, we newly carried out a HRA for post-accident human errors for the KSNP PSA model as the target of grading its quality above ASME PRA Standard Category I+. Following tasks were additionally major tasks performed in the HRA of post-accident human errors of PRiME-U3i compared with the previous PSA model of the KSNP: interviews with operators in ...

2004-10-28

397

Regulation of human ribosomal RNA transcription.  

Science.gov (United States)

We have used a cell-free polymerase I transcription system derived from HeLa cells to study the regulation of human rRNA synthesis. Analysis of deletion mutants spanning the start site of transcription at nucleotide +1 indicates that the control region affecting initiation of human rRNA synthesis is contained within sequences from nucleotides -158 to +18. This promoter region can be subdivided into (i) a central segment of approximately 40 base pair that is required for transcription and (ii) flanking sequences that influence the efficiency of transcription in vitro. We have examined the in vitro transcriptional activity of the human extract under various conditions that are thought to modulate rRNA synthesis in vivo. Cell-free extracts prepared from HeLa cells infected with adenovirus 2 synthesize human rRNA at levels greatly decreased relative to uninfected cell extracts. By contrast, in vitro ...

1983-06-01

398

In vivo hypermutation of xenotropic murine leukemia virus-related virus DNA in peripheral blood mononuclear cells of rhesus macaque by APOBEC3 proteins.  

Science.gov (United States)

The gammaretrovirus, xenotropic murine leukemia virus-related virus (XMRV), replicates to high titers in some human cell lines and is able to infect non-human primates. To determine whether APOBEC3 (A3) proteins restrict XMRV infections in a non-human primate model, we sequenced proviral DNA from peripheral blood mononuclear cells of XMRV-infected rhesus macaques. Hypermutation characteristic of A3DE, A3F and A3G activities was observed in the XMRV proviral sequences in vivo. Furthermore, expression of rhesus A3DE, A3F, or A3G in human cells inhibited XMRV infection and caused hypermutation of XMRV DNA. These studies show that some rhesus A3 isoforms are highly effective against XMRV in the blood of a non-human primate model of infection and in cultured human cells. PMID:21982221

2011-10-01

399

Chromosomal localization of the human retinoid X receptors  

Energy Technology Data Exchange (ETDEWEB)

The recently described retinoid X receptors (RXRs) respond to the novel retinoid 9-cis-retinoic acid and also serve as heterodimeric partners for the vitamin D, thyroid hormone, and retinoic acid receptors (VDR, TR, and RAR, respectively). In this work, the authors report high-resolution localization of the human RXR genes within cytogenetic bands and also within a standard reference map of cosmid DNA markers on human chromosomes. They have determined the location of the human RXR genes by pairwise hybridization of the RXR cosmids and reference markers, using fluorescence in situ hybridization. They localized (i) RXR[alpha] (RXRA) to chromosome 9 band q34.3; (ii) RXR[beta] (RXRB) to chromosome 6 band 21.3; and (iii) RXR[gamma] (RXRG) to chromosome 1 band q22-q23. Six retinoid-responsive transcription factors have been identified so far, including three retinoic acid receptors in addition to the three RXRs. Interestingly, ...

1994-04-01

400

Justice and the Human Genome Project  

Energy Technology Data Exchange (ETDEWEB)

Most of the essays gathered in this volume were first presented at a conference, Justice and the Human Genome, in Chicago in early November, 1991. The goal of the, conference was to consider questions of justice as they are and will be raised by the Human Genome Project. To achieve its goal of identifying and elucidating the challenges of justice inherent in genomic research and its social applications the conference drew together in one forum members from academia, medicine, and industry with interests divergent as rate-setting for insurance, the care of newborns, and the history of ethics. The essays in this volume address a number of theoretical and practical concerns relative to the meaning of genomic research.

1992-01-01

401

Exons, Introns and Talking Genes: The Sience Behind the Human Genome Project  

Energy Technology Data Exchange (ETDEWEB)

This book presents in simple terms the basis of molecular genetics and how it is used to obtain an understanding of the human genome. The author's central focus is the transistion of genetics from statistics to experimental manipulations, and he offers analogies that help readers visualize the genome, thereby avoiding conventional scientific presentations. He illustrates how genetics is used in scientific laboratories, in courtrooms, and in hospitals. Little is presented about the complex social and ethical issues raised by the Human Genome project.

1993-01-01

402

Educational research in Mainland China: current situation and developmental trends  

British Library Electronic Table of Contents (United Kingdom)

The influence of Confucian culture in Chinese Mainland China is reflected in the current situation and contextual trends of educational research content of educational thought of Confucianism, educational issues grounded on theoretical views of Confucianism, and the influence of the inclusiveness of Confucianism. In terms of research method, the current situation of educational research is reflected in empirical research whose methods value the construction of the metaphysical theoretical system, the guiding role of educational theories for educational reform practice, and research that enriches the literature. In terms of research value, the current situation of educational research is reflected in studies that focus on human nature, human relations, thoughts, willpower, emotion, human ri...

2011-01-01

403

Analysis of brain CT on 120 patients of human cysticercosis  

International Nuclear Information System (INIS)

A study on brain CT was made in 120 patients of human cysticercosis, which is a rare disease in Japan and clinical symptoms and laboratory data for the diagnosis were also discussed. From the point of therapeutic view, we proposed a new differentiation on brain CT of human cysticercosis, which is divided into two groups according to the alve or dead parasite. Furthermore, we proposed a new type named multiple large and small cysts type on brain CT. The idea of diagnostic standard was made integrating brain CT image, clinical symptoms and labolatory data. (author).

404

Transhumanism, medical technology and slippery slopes  

UK PubMed Central (United Kingdom)

In this article, transhumanism is considered to be a quasi‐medical ideology that seeks to promote a variety of therapeutic and human‐enhancing aims. Moderate conceptions are distinguished...Full Text Available

2006-09-01

405

Titration of diphtheria and tetanus antitoxins in sera of low titre  

UK PubMed Central (United Kingdom)

Available methods for titrating diphtheria and tetanus antitoxin at low concentrations in human or animal blood are surveyed, with special attention to the amount of serum required for the test....Full Text Available

1971-01-01

407

The Natural Statistics of Audiovisual Speech  

UK PubMed Central (United Kingdom)

Humans, like other animals, are exposed to a continuous stream of signals, which are dynamic, multimodal, extended, and time varying in nature. This complex input space must be transduced and sampled...Full Text Available

2009-07-01

408

The Elastic Properties of the Cryptococcus neoformans Capsule  

UK PubMed Central (United Kingdom)

AbstractMicrobial capsules are important for virulence, but their architecture and physical properties are poorly understood. The human pathogenic fungus Cryptococcus neoformans...Full Text Available

2009-08-19

409

The BCNT treatment planning for the Brookhaven trials on human gliomas  

International Nuclear Information System (INIS)

Boron neutron capture therapy (BNCT) trials for human glioma (glioblastoma multiform) were initiated September 1994 at the Brookhaven National Laboratory (BNL). Patients are given p-boronophenylalanine-fructose (BPA-F) intravenously as the boron carrier followed by exposure to the epithermal-neutron beam at the Brookhaven Medical Research Reactor (BMRR). The initial phase of the study is to determine safety and toxicity of the drug and irradiation procedure. The epithermal-neutron beam was developed in a joint effort by BNL and Idaho National Engineering Laboratory (INEL) researchers. For the human trials, treatment planning and radiation dose estimation is performed using the BNCT-Rtpe and the rtt-MC computer codes developed by the INEL BNCT program. This paper discusses our initial experience using these treatment planning codes for human subjects. The basic principles of BNCT have been previously documented.

410

The Allometry of Host-Pathogen Interactions  

UK PubMed Central (United Kingdom)

BackgroundUnderstanding the mechanisms that control rates of disease progression in humans and other species is an important area of research relevant to epidemiology and to translating...Full Text Available

411

Targeted integration of baboon endogenous virus in the BEVI locus on human chromosome 6.  

Science.gov (United States)

The infection of cultured human cells with baboon endogenous virus (BEV) frequently leads to an association of viral DNA with a specific genetic locus (termed BEVI, for baboon endogenous virus infection) on chromosome 6. Restriction endonuclease digestion of DNA from BEV-infected human cells and their derived somatic cell clones frequently revealed a common cellular DNA sequence in the proximity of one of the junctions between cellular DNA and the integrated virus. We propose that a short cellular DNA sequence, repeated on chromosome 6 and separated by unique DNA sequences, presents a high-affinity target for the integration of BEV in human cells. PMID:6401843

1983-01-13

412

Sequence features involved in the mechanism of 3' splice junction wobbling  

UK PubMed Central (United Kingdom)

BackgroundAlternative splicing is an important mechanism mediating the diversified functions of genes in multicellular organisms, and such event occurs in around 40-60% of human...Full Text Available

413

Selective changes of retroelement expression in human prostate cancer  

British Library Electronic Table of Contents (United Kingdom)

Retroelements constitute a large part of the human genome. These sequences are mostly silenced in normal cells, but genome-wide DNA hypomethylation in cancers might lead to their re-expression. Whether this re-expression really occurs in human cancers is largely unkown. We therefore investigated expression and DNA methylation of several classes of retroelements in human prostate cancer tissues and cell lines by quantitative reverse transcription-polymerase chain reaction and pyrosequencing, respectively. The most striking finding was strong and generalized increased expression of the HERV-K_22q11.23 provirus in cancers, including de novo expression of a spliced accessory Np9 transcript in some tumors. In parallel, DNA methylation in the long terminal repeat (LTR) decreased. Conversely, HER...

2011-01-01

414

Securing co-operation from persons supplying statistical data  

UK PubMed Central (United Kingdom)

Securing the co-operation of persons supplying information required for medical statistics is essentially a problem in human relations, and an understanding of the motivations, attitudes, and behaviour...Full Text Available

1954-01-01

415

Scanning Electron Microscopy of Sarcophagid (Diptera) Larvae Recovered from a Case of Human Cutaneous Myiasis  

Science.gov (United States)

... point dried and mounted on aluminum stubs using colloidal silver paste. Mounted specimens were observed and photographed using ... ...

416

Role of spinal cyclooxygenase in human postoperative and chronic pain  

UK PubMed Central (United Kingdom)

BackgroundNonsteroidal anti-inflammatory drugs are commonly used to treat postoperative and chronic pain. Animal studies suggest these drugs act in part by blocking...Full Text Available

2010-05-01

417

Retinoids for Treatment of Retinal Diseases  

UK PubMed Central (United Kingdom)

Knowledge about retinal photoreceptor signal transduction and the visual cycle required for normal eyesight has expanded exponentially over the past decade. Substantial progress in human genetics...Full Text Available

2010-06-01

418

Regulatory T cells in human disease and their potential for therapeutic manipulation  

UK PubMed Central (United Kingdom)

Regulatory T cells are proposed to play a central role in the maintenance of immunological tolerance in the periphery, and studies in many animal models demonstrate their capacity to inhibit inflammatory...Full Text Available

2006-05-01

419

Ras history  

UK PubMed Central (United Kingdom)

Although the roots of Ras sprouted from the rich history of retrovirus research, it was the discovery of mutationally activated RAS genes in human cancer in 1982 that stimulated an...Full Text Available

2010-07-01

420

Prenatal immunotoxicant exposure and postnatal autoimmune disease.  

UK PubMed Central (United Kingdom)

Reports in humans and rodents indicate that immune development may be altered following perinatal exposure to immunotoxic compounds, including chemotherapeutics, corticosteroids, polycyclic hydrocarbons,...Full Text Available

1999-10-01

421

Possible health effects of working with VDUs.  

UK PubMed Central (United Kingdom)

A summary of the effects presented here is given in the table. The designation "factor present" implies that there is knowledge (from human or animal studies, or both) of a specific factor(s) present...Full Text Available

1989-04-01

422

Phylogenomic analyses of malaria parasites and evolution of their exported proteins  

UK PubMed Central (United Kingdom)

BackgroundPlasmodium falciparum is the most malignant agent of human malaria. It belongs to the taxon Laverania, which includes other ape-infecting Plasmodium...Full Text Available

423

Panel warns of a crisis in american Physics  

CERN Multimedia

"Physics in America is at a crossroads and in crisis, just as humanity stands on the verge of great discoveries about the nature of matter and the universe, a panel from the National Academy of sciences concludes in a new report."

2006-01-01

424

PET imaging of tumour hypoxia  

UK PubMed Central (United Kingdom)

Tumour hypoxia represents a significant challenge to the curability of human tumours leading to treatment resistance and enhanced tumour progression. Tumour hypoxia can be detected by non-invasive and...Full Text Available

426

Neurocysticercosis  

UK PubMed Central (United Kingdom)

A single enhancing lesion in the brain parenchyma, also called an inflammatory granuloma, is a frequent neurologic diagnosis. One of the commonest causes of this lesion is human neurocysticercosis,...Full Text Available

2010-08-17

427

NASA's Strategic Human Capital Implementation Plan - NASA Headquarters  

Science.gov (United States)

o If retaining CSRS/FERS, transferred employee will be credited with accumulated sick leave o Be reimbursed for travel, transportation, relocation costs ...

428

NASA - Waste Not  

Science.gov (United States)

Jun 4, 2004 ... On a two-year trip to Mars, according to one estimate, a crew of six humans will generate more than six tons of solid organic waste--much of ...

429

Multifunctional, Boron-Foam Based Radiation Shielding  

Science.gov (United States)

PROPOSAL NUMBER: 04 B3.09-7744. SUBTOPIC TITLE: Radiation Shielding to Protect Humans. PROPOSAL TITLE: Multifunctional, Boron-Foam Based ...

430

Monthly electricity usage at Australian Antarctic Stations - NASA  

Science.gov (United States)

Record Search Query: Science Keywords>HUMAN DIMENSIONS>INFRASTRUCTURE> ELECTRICITY. Monthly electricity usage at Australian Antarctic Stations ...

431

Molecular cloning and analysis of lymphokines. Volume 13  

Energy Technology Data Exchange (ETDEWEB)

These proceedings collect papers on the subject of lymphokines. Topics include: DNA-cloning of mouse and human lymphokine genes, inteferons, interleukins, gene expression, tumor necrosis factors, and recombinant DNA.

1987-01-01

432

Molecular Genetics and Carcinogenesis Section  

Science.gov (United States)

The Molecular Genetics and Carcinogenesis Section conducts studies using human epithelial cells to assess: activation of proto-oncogenes by chemical and physical carcinogens; inactivation and dysregulation of tumor suppressor genes by chemical and physical

433

Molecular Characterization of Cryptosporidium Oocysts in Samples of Raw Surface Water and Wastewater  

UK PubMed Central (United Kingdom)

Recent molecular characterizations of Cryptosporidium parasites make it possible to differentiate the human-pathogenic Cryptosporidium parasites from those that do...Full Text Available

2001-03-01

435

Metals and kidney autoimmunity.  

UK PubMed Central (United Kingdom)

The causes of autoimmune responses leading to human kidney pathology remain unknown. However, environmental agents such as microorganisms and/or xenobiotics are good candidates for that role. Metals,...Full Text Available

1999-10-01

437

Magnetic resonance imaging in human lymphodemas  

International Nuclear Information System (INIS)

The MRI's of 16 patients with either primary or secondary lymphatic disorders are evluated and the findings are compared to those from lymphangioscintigraphy or surgery. (author).

1989-09-02

438

Liver Carcinogenesis Unit  

Science.gov (United States)

The Liver Carcinogenesis Section uses the modern technologies of molecular biology, cell biology, protein chemistry and genetics to investigate the biochemical and genetic pathways involved in human liver cancer.

439

Lighting in indoor environments: Visual and non-visual effects of light sources with different spectral power distributions  

British Library Electronic Table of Contents (United Kingdom)

Since the end of the 1990s, good quality lighting was that which balanced the needs of humans, economic and environmental issues, and architectural design. Recent studies aimed to find a correlation between environmental lighting and human performance and health, with positive results. What is known, is that insufficient or inappropriate light exposure can disrupt standard human rhythms which may result in adverse consequences for performance, safety, health. By studying the relationship between human physiology and light, research in photobiology has advanced to the point where some attempts to foresee what the lighting practice will be in future. The question is if lighting practice and lighting practitioners are ready for changes. This paper has the aim of introducing the recent discove...

2011-01-01

440

Legionella Pneumophila Transcriptome during Intracellular Multiplication in Human Macrophages  

UK PubMed Central (United Kingdom)

Legionella pneumophila is the causative agent of Legionnaires’ disease, an acute pulmonary infection. L. pneumophila is able to infect and multiply in both...Full Text Available

441

Job Opportunities - Office Of Human Capital Management - NASA  

Science.gov (United States)

Jun 6, 2011 ... Sick leave is earned at a rate of 4 hours per pay period. ... The Federal Employees Retirement System (FERS) is a three-tiered pension plan ...

442

Jeffrey W. McCandless: Computer Vision - NASA Vision Group  

Science.gov (United States)

Jeffrey W. McCandless is a post-doctoral researcher at NASA Ames Research Center in the Human Factors Research and Technology Division.

444

Interactive computer programs in sequence data analysis.  

UK PubMed Central (United Kingdom)

We present interactive computer programs for the analysis of nucleic acid sequences. In order to handle these programs, minimum computer experience is sufficient. The nucleotide sequence of the human...Full Text Available

1982-01-11

445

In vitro atrazine-exposure inhibits human natural killer cell lytic granule release  

British Library Electronic Table of Contents (United Kingdom)

The herbicide atrazine is a known immunotoxicant and an inhibitor of human natural killer (NK) cell lytic function. The precise changes in NK cell lytic function following atrazine exposure have not been fully elucidated. The current study identifies the point at which atrazine exerts its affect on the stepwise process of human NK cell-mediated lyses of the K562 target cell line. Using intracellular staining of human peripheral blood lymphocytes, it was determined that a 24-h in vitro exposure to atrazine did not decrease the level of NK cell lytic proteins granzyme A, granzyme B or perforin. Thus, it was hypothesized that atrazine exposure was inhibiting the ability of the NK cells to bind to the target cell and subsequently inhibit the release of lytic protein from the NK cell. To test t...

2007-01-01

446

In vitro activity and human pharmacokinetics of teicoplanin.  

UK PubMed Central (United Kingdom)

The in vitro activity of teicoplanin, a new antibiotic related to vancomycin, was determined against 456 gram-positive cocci. The activity of teicoplanin in comparison with that of vancomycin was similar...Full Text Available

1984-12-01

447

Immunology of schistosomiasis*  

UK PubMed Central (United Kingdom)

This Memorandum, after summarizing the life cycle of the different species of human schistosome, reviews the present knowledge of the immunology of schistosomiasis. Each stage of the parasite contains...Full Text Available

1974-01-01

448

Immortalization of human foreskin keratinocytes by various human papillomavirus DNAs corresponds to their association with cervical carcinoma  

Energy Technology Data Exchange (ETDEWEB)

Normal human foreskin keratinocytes cotransfected with the neomycin resistance gene and recombinant human papillomavirus (HPV) DNAs (types 16, 18, 31, and 33) that have a high or moderate association with cervical malignancy acquired immortality and contained integrated and transcriptionally active viral genomes. Only transcripts from the intact E6 and E7 genes were detected in at least one cell line, suggesting that one or both of these genes are responsible for immortalization. Recombinant HPV DNAs with low or no oncogenic potential for cervical cancer (HPV1a, -5, -6b, and -11) induced small G418-resistant colonies that senesced as did the nontransfected cells. These colonies contained only episomal virus DNA; therefore, integration of HPV sequences is important for immortalization of keratinocytes. This study suggests that the virus-encoded immortalization function contributes to the pathogenesis of cervical carcinoma.

1989-01-01

449

Human viral gastroenteritis.  

UK PubMed Central (United Kingdom)

During the last 15 years, several different groups of fastidious viruses that are responsible for a large proportion of acute viral gastroenteritis cases have been discovered by the electron microscopic...Full Text Available

1989-01-01

450

Human and rat mast cell high-affinity immunoglobulin E receptors: Characterization of putative. alpha. -chain gene products  

Energy Technology Data Exchange (ETDEWEB)

The authors have cloned and determined the entire nucleotide sequence of cDNAs corresponding to the putative {alpha} subunits of the human and rat mast cell high-affinity IgE receptors. Both human and rat cDNAs encode an NH{sub 2}-terminal signal peptide, two immunoglobulin-like extracellular domains (encoded by discrete exons), a hydrophobic transmembrane region, and a positively charged cytoplasmic tail. The human and rat {alpha} subunits share an overall homology with one another and the immunoglobulin gene family, suggesting that they arose from a common ancestral gene and continue to share structural homology with their ligands. In addition, the rat gene is transcribed into at least three distinct forms, each of which yields a somewhat different coding sequence.

1988-03-01

451

Human Interfaces for Robotic Satellite Servicing  

Science.gov (United States)

... of China Lake Naval Weapons Center, California. ... Figure 4: The Space-Based Laser cleaning ... of Aeronautics and Astronautics (AIAA) Space 2001 ...

2011-05-13

452

Human Factors Assessment of the UH-60M Common Avionics ...  

Science.gov (United States)

... 1768 1475 360 to 3400 ... The TSC provided an independent assessment of SA based on ... Complexity of Situation Degree of complication (number of ...

2005-12-01

453

Homocysteine and Familial Longevity: The Leiden Longevity Study  

UK PubMed Central (United Kingdom)

Homocysteine concentrations are a read-out of methionine metabolism and have been related to changes in lifespan in animal models. In humans, high homocysteine concentrations are an important predictor...Full Text Available

454

Healthy aging and disease: role for telomere biology?  

UK PubMed Central (United Kingdom)

Aging is a biological process that affects most cells, organisms and species. Human aging is associated with increased susceptibility to a variety of chronic diseases, including cardiovascular disease,...Full Text Available

2011-05-01

455

Health effects of indoor odorants.  

UK PubMed Central (United Kingdom)

People assess the quality of the air indoors primarily on the basis of its odors and on their perception of associated health risk. The major current contributors to indoor odorants are human occupant...Full Text Available

1991-11-01

456

Health and environmental chemistry: Analytical techniques, data management, and quality assurance. Volume 1, Manual  

Energy Technology Data Exchange (ETDEWEB)

Analytical procedures are described for the determination of organic compounds, metals and radioisotopes in environmental materials, human tissues, urine, feces, and waste water.

1993-11-01

457

Health Topics beginning with A - National Institutes of Health...  

Science.gov (United States)

Skip Over Navigation Links U.S. Department of Health & Human Services National Institutes of Health NIH...Turning Discovery into Health For Employees Staff Directory En Español...

2011-08-26

458

HDL in humans with cardiovascular disease exhibits a proteomic signature  

UK PubMed Central (United Kingdom)

BackgroundAlterations in protein composition and oxidative damage of high-density lipoprotein (HDL) have been proposed to impair the cardioprotective properties of...Full Text Available

2010-07-04

459

Going beyond panaceas  

UK PubMed Central (United Kingdom)

In the context of governance of human–environment interactions, a panacea refers to a blueprint for a single type of governance system (e.g., government ownership, privatization, community property)...Full Text Available

2007-09-25

460

Genomics of human longevity  

UK PubMed Central (United Kingdom)

In animal models, single-gene mutations in genes involved in insulin/IGF and target of rapamycin signalling pathways extend lifespan to a considerable extent. The genetic, genomic and epigenetic influences...Full Text Available

2011-01-12

461

Functionally defined substates within the human embryonic stem cell compartment.  

Science.gov (United States)

Human embryonic stem (ES) cells can undergo spontaneously differentiation in standard culture conditions, demonstrating that the undifferentiated state is relatively unstable. The heterogeneous expression of SSEA3 observed within human ES colonies, provides a means to examine undifferentiated stem cell substates. Through functional testing of single cells we have shown that undifferentiated ES cells can be segregated into functionally discrete subpopulations on the basis of SSEA3 expression: SSEA3(High), SSEA(Low) and SSEA3(Negative). Human ES subpopulations were found to be interconvertible, but they possess distinct properties when challenged to differentiate along the neural lineage. These data suggest that ES cells with pluripotent/self-renewal capacities can exhibit different responses to induction of differentiation. PMID:21763622

2011-05-11

462

Fluence- and exposure-to-dose conversion for human whole-body gamma irradiation  

International Nuclear Information System (INIS)

... kev range 10-100 kev range 100-1000 man mev range 01-10 personnel

1978-01-01

463

Evaluation of phenylpiperazines as targeting agents for neuroblastoma.  

UK PubMed Central (United Kingdom)

The potential of radiolabelled phenylpiperazines as agents for the detection and therapy of tumours of neural crest origin was evaluated by in vitro pharmacological studies with human neuroblastoma...Full Text Available

1996-09-01

464

Estimation of Human Toxicity From Animal Inhalation Toxicity ...  

Science.gov (United States)

... Bisgard, GE, Ruiz, AV, Grover, RF & Will, JA, "Ventilatory control in the ... Watkins, BE, Riegle, GD & Heisey, SR, "Respiratory responses to ACTH and ...

1997-10-01

466

Epigenetic mechanisms underlying human epileptic disorders and the process of epileptogenesis  

UK PubMed Central (United Kingdom)

The rapidly emerging science of epigenetics and epigenomic medicine promises to reveal novel insights into the susceptibility to and the onset and progression of epileptic disorders. Epigenetic...Full Text Available

2010-07-01

467

Effector Glycosyltransferases in Legionella  

UK PubMed Central (United Kingdom)

Legionella causes severe pneumonia in humans. The pathogen produces an array of effectors, which interfere with host cell functions. Among them are the glucosyltransferases Lgt1, Lgt2...Full Text Available

468

Effect of Registration on Cyclical Kinematic Data  

UK PubMed Central (United Kingdom)

Given growing interest in Functional Data Analysis (FDA) as a useful method for analyzing human movement data, it is critical to understand the effects of standard FDA procedures, including...Full Text Available

2010-08-26

469

Differential immunotoxic effects of inorganic and organic mercury species in vitro  

British Library Electronic Table of Contents (United Kingdom)

Despite the fact that humans are exposed to multiple forms of mercury (elemental, inorganic, and organic), most research on mercury toxicity has focused on methylmercury (MeHg) and on neurotoxic outcomes and mechanisms. Recent work has indicated that the immunotoxic effects of mercury compounds may be significant contributors to human disease as well as mechanistically relevant to other target organ toxicities. In this study, we compared the effects of inorganic Hg (iHg) to organic Hg species (MeHg and ethylmercury, EtHg) in human peripheral blood mononuclear cells (PBMCs) in vitro at sub-cytotoxic concentrations, using methods developed to characterize response of human PBMCs to iHg in vitro. PBMCs were isolated from six volunteer blood donors (three males and three females) and cultured ...

2010-01-01

470

Developmentally programmed endoreduplication in animals  

UK PubMed Central (United Kingdom)

Development of a fertilized egg into an adult human requires trillions of cell divisions, the vast majority of which duplicate their genome once and only once. Nevertheless, trophoblast giant...Full Text Available

2009-05-15

471

Development of a microarray for identification of pathogenic Clostridium species  

UK PubMed Central (United Kingdom)

In recent years, Clostridium species have rapidly reemerged as human and animal pathogens. The detection and identification of pathogenic Clostridium species...Full Text Available

2010-02-01

472

Developing defined culture systems for human pluripotent stem cells  

British Library Electronic Table of Contents (United Kingdom)

Human pluripotent stem cells hold promising potential in many therapeutics applications including regenerative medicine and drug discovery. Over the past three decades, embryonic stem cell research has illustrated that embryonic stem cells possess two important and distinct properties: the ability to continuously self-renew and the ability to differentiate into all specialized cell types. In this article, we will discuss the continuing evolution of human pluripotent stem cell culture by examining requirements needed for the maintenance of self-renewal in vitro. We will also elaborate on the future direction of the field toward generating a robust and completely defined culture system, which has brought forth collaborations amongst biologists and engineers. As human pluripotent stem cell re...

2011-01-01

474

Depleted uranium human health risk assessment, Jefferson Proving Ground, Indiana  

Energy Technology Data Exchange (ETDEWEB)

The risk to human health from fragments of depleted uranium (DU) at Jefferson Proving Ground (JPG) was estimated using two types of ecosystem pathway models. A steady-state, model of the JPG area was developed to examine the effects of DU in soils, water, and vegetation on deer that were hunted and consumed by humans. The RESRAD code was also used to estimate the effects of farming the impact area and consuming the products derived from the farm. The steady-state model showed that minimal doses to humans are expected from consumption of deer that inhabit the impact area. Median values for doses to humans range from about 1 mrem ({plus_minus}2.4) to 0.04 mrem ({plus_minus}0.13) and translate to less than 1 {times} 10{sup {minus}6} detriments (excess cancers) in the population. Monte Carlo simulation of the steady-state model was used to derive the probability distributions from which the median values ...

1994-04-29

475

Deforestation Plays Critical Climate Change Role - NASA Earth ...  

Science.gov (United States)

May 11, 2007 ... "Deforestation in the tropics accounts for nearly 20 per cent of carbon emissions due to human activities," Dr. Canadell says. ...

476

Current Projects - Human Nutrition Research Center on Aging ...  

Science.gov (United States)

diet and genetic obesity metabolic defects and inflammation. To determine the role of adipocyte death in promoting adipose tissue inflammation and insulin resistance in animal...

2011-08-31

477

Cuba's response to the HIV epidemic.  

UK PubMed Central (United Kingdom)

BACKGROUND: Cuba's response to the human immunodeficiency virus (HIV) epidemic has been to conduct mass testing of the population to ascertain seroprevalence, to enforce mandatory relative quarantine...Full Text Available

1991-05-01

478

Continuous human cell lines and method of making same  

Energy Technology Data Exchange (ETDEWEB)

Substantially genetically stable continuous human cell lines derived from normal human mammary epithelial cells (HMEC) and processes for making and using the same. In a preferred embodiment, the cell lines are derived by treating normal human mammary epithelial tissue with a chemical carcinogen such as benzo(a)pyrene. The novel cell lines serve as useful substrates for elucidating the potential effects of a number of toxins, carcinogens and mutagens as well as of the addition of exogenous genetic material. The autogenic parent cells from which the cell lines are derived serve as convenient control samples for testing. The cell lines are not neoplastically transformed, although they have acquired several properties which distinguish them from their normal progenitors. 2 tabs.

1985-07-01

479

Comparison of internal emitter radiobiology in animals and humans  

Energy Technology Data Exchange (ETDEWEB)

Investigations of radionuclide metabolism and effects in various mammalian species revealed important similarities between animals and humans and between some animal species. These include skeletal deposition of radium and radiostrontium in bone volume; deposition on bone surfaces of plutonium and other actinides; liver deposition of actinides; induction of skeletal or liver malignancies by these radionuclides; induction of tooth and jaw abnormalities; mammary cancer induction by radium in humans and in the beagle; depression of circulating cells in blood; and induction of bone fractures. There are also inter-species differences that may not have been noted if multiple species (including humans) had not been studied. Some of these are more rapid excretion of radium in humans compared with most other mammals; induction by radium of eye melanomas in animals but not humans; rapid loss ...

1997-01-01

480

Cloning of the cDNA for the human. beta. /sub 1/-adrenergic receptor  

Energy Technology Data Exchange (ETDEWEB)

Screening of a human placenta lambdagt11 library has led to the isolation of the cDNA for the human ..beta../sub 1/-adrenergic receptor (..beta../sub 1/AR). Used as the probe was the human genomic clone termed G-21. This clone, which contains an intronless gene for a putative receptor, was previously isolated by virtue of its cross hybridization with the human ..beta../sub 2/-adrenergic receptor (..beta../sub 2/AR). The 2.4-kilobase cDNA for the human ..beta../sub 1/AR encodes a protein of 477 amino acid residues that is 69% homologous with the avian ..beta..AR but only 54% homologous with the human ..beta../sub 2/AR. This suggests that the avian gene encoding ..beta..AR and the human gene encoding ..beta../sub 1/AR evolved from a common ancestral gene. RNA blot analysis indicates a message of 2.5 kilobases in rat tissues, with a pattern of ...

1987-11-01

481

Clinical significance of coagulase-negative staphylococci.  

UK PubMed Central (United Kingdom)

Although coagulase-negative staphylococci (C-NS) have been implicated in certain human infections, they are generally regarded as contaminants, and their clinical significance is questioned. To assess...Full Text Available

1982-08-01

482

Cis-regulatory mutations in human disease  

UK PubMed Central (United Kingdom)

Cis-acting regulatory sequences are required for the proper temporal and spatial control of gene expression. Variation in gene expression is highly heritable and a significant determinant...Full Text Available

2009-07-01

483

Chromosomal localization and structure of the human type II IMP dehydrogenase gene  

Energy Technology Data Exchange (ETDEWEB)

We determined the chromosomal localization and structure of the gene encoding human type II inosine 5{prime}-monophosphate dehydrogenase (IMPDH, EC 1.1.1.205), an enzyme associated with cellular proliferation, malignant transformation, and differentiation. Using polymerase chain reaction (PCR) primers specific for type II IMPDH, we screened a panel of human-Chinese hamster cell somatic hybrids and a separate deletion panel of chromosome 3 hybrids and localized the gene to 3p21.1{yields}p24.2. Two overlapping yeast artificial chromosome clones containing the full gene for type II IMPDH were isolated and a physical map of 117 kb of human genomic DNA in this region of chromosome 3 was constructed. The gene for type II IMPDH was localized and oriented on this map and found to span no more than 12.5 kb.

1994-05-01

484

Cholinesterase for Prophylactics of Poisoning by Organophosphorous Inhibitors  

International Science & Technology Center (ISTC)

The Production of Highly Active Human Blood Plasma Butyrylcholinesterase Preparation by Gene Engineering Methods to Create Protective Means against Poisoning by Organophosphorous Cholinesterase Inhibitors

485

Cellular and molecular response of human macrophages exposed to Aggregatibacter actinomycetemcomitans leukotoxin  

UK PubMed Central (United Kingdom)

Aggregatibacter (Actinobacillus) actinomycetemcomitans is a facultative anaerobic gram-negative bacterium associated with severe forms of periodontitis. A leukotoxin, which belongs...Full Text Available

2011-03-01

486

Cancer gene discovery in mouse and man  

UK PubMed Central (United Kingdom)

AbstractThe elucidation of the human and mouse genome sequence and developments in high-throughput genome analysis, and in computational tools, have made it possible to profile entire...Full Text Available

2009-12-01

487

Building the Perfect Parasite: Cell Division in Apicomplexa  

UK PubMed Central (United Kingdom)

Apicomplexans are pathogens responsible for malaria, toxoplasmosis, and crytposporidiosis in humans, and a wide range of livestock diseases. These unicellular eukaryotes are stealthy invaders, sheltering...Full Text Available

2007-06-01

488

Biology of Pseudomonas stutzeri  

UK PubMed Central (United Kingdom)

Pseudomonas stutzeri is a nonfluorescent denitrifying bacterium widely distributed in the environment, and it has also been isolated as an opportunistic pathogen from humans. Over the...Full Text Available

2006-06-01

489

Battle Management Command and Control (BMC2) Human ...  

Science.gov (United States)

... For communication systems that employ spatial audio technology to separate intercom and/or radio channels, configurations of the spatial ...

2005-06-01

490

Avoidance of hydrolyzed casein by mice  

UK PubMed Central (United Kingdom)

When casein, a milk protein, is hydrolyzed, it renders human foods that contain it (e.g., hypoallergenic infant formula, cheeses) distasteful to many people. This rejection...Full Text Available

2008-01-28

491

Augustine panel visits Huntsville to discuss future of human ...  

Science.gov (United States)

Aug 6, 2009 ... be cleaned with common household disinfectants regularly and after increased crowd contact. Marshall's Emergency Operations Center and the ...

492

Arrival ... - Human Factors Research and Technology Division - NASA  

Science.gov (United States)

airborne separation assistance systems (ASAS) to ... operations should be limited to the outer traffic flow ...... AGARD Meeting on Machine Intelligence in Air ...

493

Are animal models predictive for humans?  

UK PubMed Central (United Kingdom)

It is one of the central aims of the philosophy of science to elucidate the meanings of scientific terms and also to think critically about their application. The focus of this essay is the scientific...Full Text Available

494

Analysis of codon usage and nucleotide composition bias in polioviruses  

UK PubMed Central (United Kingdom)

BackgroundPoliovirus, the causative agent of poliomyelitis, is a human enterovirus and a member of the family of Picornaviridae and among the most rapidly evolving viruses known....Full Text Available

495

Aging in Language Dynamics  

UK PubMed Central (United Kingdom)

Human languages evolve continuously, and a puzzling problem is how to reconcile the apparent robustness of most of the deep linguistic structures we use with the evidence that they undergo possibly...Full Text Available

496

Adhesion of Vibrio cholerae to Granular Starches  

UK PubMed Central (United Kingdom)

Cholera is a severe diarrheal disease caused by specific serogroups of Vibrio cholerae that are pathogenic to humans. Cholera can become epidemic and deadly without adequate medical...Full Text Available

2005-08-01

497

AIR ... - Human Factors Research and Technology Division - NASA  

Science.gov (United States)

TRACON controller, traffic flow manager, or pilot. .... separation violations to individual controller and ..... System, AGARD Meeting on Machine Intelligence ...

498

A continuum model of protrusion of pseudopod in leukocytes.  

UK PubMed Central (United Kingdom)

The morphology of human leukocytes, the biochemistry of actin polymerization, and the theory of continuum mechanics are used to model the pseudopod protrusion process of leukocytes. In the proposed...Full Text Available

1988-12-01

499

A Human-Centered Design and Evaluation Framework for Information Search  

UK PubMed Central (United Kingdom)

Information search in a distributed environment is an interactive process between the user and the artifact. How the information is distributed across the user and the artifact determines the efficacy...Full Text Available

2005-01-01