WorldWideScience
1

The influence of chemically active gas on the light emission of metallic targets bombarded by positive ions  

International Nuclear Information System (INIS)

The introduction of oxygen in the vicinity of a metallic target surface, bombarded with positive argon ions of twenty kiloelectron-volts, increases the number of sputtered atoms in the excited state. This phenomenon of exaltation, very sensitive in the case of nickel and aluminium, is much less marked in the case of molybdenum. Moreover, the emission of excited particles coming from the beam's ions is not modified. A quantum-mechanical model of a kinetic emission process, which permits the interpretation of the clean metallic target's emission phenomena, seems insufficient to explain all of the results obtained in the presence of oxygen. In this last case one can therfore use a thermodynamic model in which excited metallic particles can be formed directly by chemical surface reactions of neutralization or reduction. (orig.).

2

Particle emission from low energy proton bombardment of TiH{sub 2} and TiD{sub 2}  

Energy Technology Data Exchange (ETDEWEB)

TiH{sub 2} and TiD{sub 2} thick targets were bombarded with 100 to 200 keV protons. Evidence for nuclear reactions was obtained by means of a surface barrier particle detector. Proton irradiation of TiD{sub 2} produced the following observations: {alpha} particle emission identified as (p, {alpha}) reactions from {sup 11}B and {sup 7}Li impurities in the target at ppm concentrations; and {approx}3 MeV proton and {approx}1 MeV triton emission from secondary D-D reactions caused by elastic scattering of the primary proton with a target deuteron. A 3.9 MeV {alpha} particle peak measured by others was not observed. (author)

2002-03-01

3

Momentum transfer in 30-200 MeV/sup 4/He induced reaction with /sup 59/Co  

Energy Technology Data Exchange (ETDEWEB)

Thick-target recoil ranges of radioactive nuclei produced in 30-200 MeV alpha-particle bombardment of /sup 59/Co have been used to deduce the longitudinal momentum transfer per projectile nucleon (psub(parallel)/A) as a function of residue mass and bombarding energy. The average value of psub(parallel)/A increases monotonically with bombarding energy and reaches a maximum value of proportional160 MeV/c at proportional23 MeV/u, and decreases thereafter. The maximum value of psub(parallel)/A is equal to the incident momentum up to proportional23 MeV/u and saturates at a value of proportional220 MeV/c beyond this energy.

1984-03-01

4

Alpha-particle emission from carbon bombarded with neutrons below 30 MeV  

Energy Technology Data Exchange (ETDEWEB)

Alpha-particle emission induced by neutron bombardment of carbon has been studied from threshold to over 30 MeV using the spallation neutron source at WNR/LAMPF. Targets include thin foils of CH{sub 2} and thicker foils of CH and polycrystalline graphite. Comparisons are made with evaluated data. Values for KERMA (kinetic energy released in materials) based on the results will be presented and compared with those obtained through other experimental approaches.

1994-07-01

5

The separation of "2"0"3Pb from a thallium target  

International Nuclear Information System (INIS)

"2"0"3Pb, an ideal radionuclide for toxicological studies, can be artificially produced by bombardment of a thallium target but due to the extreme toxicity of thallium the lead has to be separated completely from the thallium. A single step method is here described consisting of removing the thallium from a dilute acid chloride solution using a continuous ethyl ether extraction. Essentially all of the thallium and almost none of the lead is removed in a 3-hr extraction. Because the ether is recycled, only about 30 ml are needed. If other contaminants are introduced from the bombardment and its subsequent manipulations, an additional step is used in which the lead is extracted from an iodide solution with methyl isopropyl keton. (U.K.).

6

Production of radioisotopes in the ORNL 86-inch cyclotron  

Energy Technology Data Exchange (ETDEWEB)

The radioisotope production facilities and programs of the 86-Inch Cyclotron are reviewed in this presentation. The 86-Inch Cyclotron is designed to accelerate protons to a maximum energy of 22 MeV for internal targets. These protons are used to bombard metals that are electroplated, potted or soldered to water-cooled plates. Additionally, metals and inorganic compounds are bombarded in water-cooled tube targets. High radioisotope production rates are obtained by beam currents as large as 3 mA. Production rates for /sup 11/C, /sup 57/Co, /sup 67/Ga, /sup 68/Ge, /sup 109/Cd, and other isotopes are presented. The production of /sup 11/C for the carboxyl labeling of amino acids in cooperation with Oak Ridge Associated Universities is discussed. The 86-Inch Cyclotron is used for those programs requiring a larger beam current than is available from commercial cyclotrons.

1981-04-01

7

The production of carrier-free lead-203  

International Nuclear Information System (INIS)

The chemical separation of carrier-free "2"0"3Pb following deuterium bombardment of a "2"0"3Tl target is described. Coprecipitation from strontium sulphate was used to separate the "2"0"3Pb from a solution of the thallium target in sulphuric acid. The SrSO_4 precipitate was filtered, washed and dissolved in hydrochloric acid, from which "2"0"3Pb was again separated by precipitation on sodium chloride from a strongly acid solution. Advantages of the system are discussed and optimum conditions given. (U.K.).

8

Production of carrier-free lead-203  

Energy Technology Data Exchange (ETDEWEB)

The chemical separation of carrier-free /sup 203/Pb following deuterium bombardment of a /sup 203/Tl target is described. Coprecipitation from strontium sulphate was used to separate the /sup 203/Pb from a solution of the thallium target in sulphuric acid. The SrSO/sub 4/ precipitate was filtered, washed and dissolved in hydrochloric acid, from which /sup 203/Pb was again separated by precipitation on sodium chloride from a strongly acid solution. Advantages of the system are discussed and optimum conditions given.

1982-07-01

9

The influence of target backing on ion-beam electron spectra  

International Nuclear Information System (INIS)

Several different aspects of the influence of the target backing on in-beam electron spectra following compound nuclear reactions induced by accelerated ions at tandem energies irradiating backed targets are discussed in detail. This discussion is illustrated by a few typical examples, such as "1"2C"5"+ and "3"1P"1"0"+ beams at 4 MeV/u bombarding Sn(+Be), Sn(+Au), Pb(+C) backed targets. Moreover, the relative influence of electron backscattering, electron Doppler shift and Doppler broadening as well as #delta#-electron emission on the low energy electron spectra (E_e#<=#100 keV) obtained under such conditions are investigated in the frame of the available experimental data. (orig.).

10

Spectroscopy of neutron-rich Fe isotopes populated in the "6"4Ni+"2"3"8U reaction  

International Nuclear Information System (INIS)

The neutron-rich Fe isotopes from A=61 to 66 were studied through multinucleon transfer reactions by bombarding a "2"3"8U target with a 400 MeV "6"4Ni beam. Unambiguous identification of prompt #gamma# rays belonging to each nucleus was achieved using coincidence relationships with the ions detected in a high-acceptance magnetic spectrometer. The new data extend our knowledge of the level structure of Fe isotopes, which is discussed in terms of the systematics of the region and compared with large-scale shell-model calculations.

2007-09-01

11

Simple method for high-temperature separation of thallium isotopes from a bulk lead target  

Energy Technology Data Exchange (ETDEWEB)

A method is proposed for the quantitative isolation of radiothallium in gas form from proton-bombarded lead of mass up to 20 g. The molten lead is kept at about 800 K in hydrofluoric-acid vapor (HF/H/sub 2/O approx. = 1) at a reduced pressure (less than or equal to4 Pa). We used 99.9% lead with the U-240 cyclotron at the Nuclear Research Institute, Academy of Sciences of the Ukrainian SSR, or the phasotron at the Join Nuclear Research Institute, which gave protons at 65 and 680 MeV correspondingly.

1988-03-01

12

Simple method for high-temperature separation of thallium isotopes from a bulk lead target  

International Nuclear Information System (INIS)

A method is proposed for the quantitative isolation of radiothallium in gas form from proton-bombarded lead of mass up to 20 g. The molten lead is kept at about 800 K in hydrofluoric-acid vapor (HF/H_2O #approx =# 1) at a reduced pressure (#<=#4 Pa). We used 99.9% lead with the U-240 cyclotron at the Nuclear Research Institute, Academy of Sciences of the Ukrainian SSR, or the phasotron at the Join Nuclear Research Institute, which gave protons at 65 and 680 MeV correspondingly.

13

Direct surface transfer reaction to the continuum states induced by 341 MeV /sup 20/Ne beam on /sup 197/Au target nuclei  

Energy Technology Data Exchange (ETDEWEB)

The energy spectra of few-nucleon transfer reactions obtained by bombarding a /sup 197/Au nucleus with the 341 MeV /sup 20/Ne beam of the Berkeley cyclotron have been analysed successfully in terms of direct surface transfer reactions populating the continuum states. At the grazing angle we are dealing with one-step processes; at forward angle two-step processes have to be taken into account.

1985-06-06

14

The isolation of "1"3"9Ce after production by a proton-induced nuclear reaction on praseodymium  

International Nuclear Information System (INIS)

A method, based on anion exchange chromatography, is presented for the isolation of "1"3"9Ce after production by a proton-induced nuclear reaction on a thick praseodymium target. After bombardment the target is dissolved in nitric acid and "1"3"9Ce oxidised to the Ce(IV) oxidation state with bromic acid. "1"3"9Ce is then separated form the praseodymium by anion exchange chromatography on a Ag MP-1 resin column in a nitric acid - bromic acid mixture. "1"3"9Ce is sorbed onto the resin column and praseodymium eluted with the acid mixture. The bromic acid is washed out of the column with nitric acid and "1"3"9Ce finally eluted with dilute nitric acid containing sulphur dioxide.

2001-02-17

15

Separation of lead-203 from cyclotron-bombarded thallium targets by ion-exchange chromatography  

Energy Technology Data Exchange (ETDEWEB)

A simple method is presented for the separation of lead-203 from copper-backed thallium cyclotron targets. The procedure involves cation-exchange chromatography in hydrochloric acid and hydrochloric acid-acetone mixtures. Further purification involves anion-exchange chromatography in nitric acid-hydrobromic acid mixtures. A cation-exchange column containing 3.0 g of resin can handle as much as 15 g of thallium and 160 mg of copper. An anion-exchange column containing 3.0 g of resin can separate lead from up to 200 mg of thallium and 10 mg of copper. Separations are extremely sharp and less than 0.1 ..mu..g of thallium and less than 0.1 ..mu..g of copper remain in the lead-203 fraction.

1982-07-01

16

Separation of lead-203 from cyclotron-bombarded thallium targets by ion-exchange chromatography  

International Nuclear Information System (INIS)

A simple method is presented for the separation of lead-203 from copper-backed thallium cyclotron targets. The procedure involves cation-exchange chromatography in hydrochloric acid and hydrochloric acid-acetone mixtures. Further purification involves anion-exchange chromatography in nitric acid-hydrobromic acid mixtures. A cation-exchange column containing 3.0 g of resin can handle as much as 15 g of thallium and 160 mg of copper. An anion-exchange column containing 3.0 g of resin can separate lead from up to 200 mg of thallium and 10 mg of copper. Separations are extremely sharp and less than 0.1 #mu#g of thallium and less than 0.1 #mu#g of copper remain in the lead-203 fraction. (author).

17

Separation of /sup 203/Pb by ion-exchange chromatography on Chelex 100 after production of /sup 203/Pb by the Pb(p,xn)/sup 203/Bi/sup EC. beta. +/ -> /sup 203/Pb nuclear reaction  

Energy Technology Data Exchange (ETDEWEB)

Bismuth radioisotopes, produced by 50-MeV proton bombardment of a lead target in a cyclotron, are separated from the lead target material by ion-exchange chromatography on a column containing 5.0 ml of Chelex 100. After a decay period of 24 hr, the /sup 203/Pb formed in situ is eluted from the column and then separated from /sup 200/Tl and /sup 201/Tl on a second ion-exchange column containing 0.5 ml of Chelex 100. Separations are sharp and carrier-free /sup 203/Pb is obtained.

1989-04-01

18

Ion-induced M X-ray emission from heavy lanthanides  

International Nuclear Information System (INIS)

Thick targets of several heavy lanthanide (Ho-Lu) compounds were bombarded by protons and "3He ions of 3 MeV/amu, and M_#alpha# and M_#beta# X-rays were measured with a crystal spectrometer. Ionization probabilities of the N-shell for zero impact parameter were obtained from the X-ray intensity ratio for proton and "3He ion impacts. A shell dependence of the ionization probability was found in a scaling plot. X-ray spectra of lanthanide compounds were compared and no chemical effect was observed. This result is considered to be due to the fact that the main component of M_#alpha# and M_#beta# lines is for radiative transition after the refilling of the 4f orbit (3d"-"14f"n"+"1 #-># 4f"n) where n denotes the number of 4f electrons of the target atom before ionization. (orig.).

1987-12-01

19

Preparation of a "6"2Zn-"6"2Cu generator and of "6"1Cu following alpha particle irradiation of a nickel target  

International Nuclear Information System (INIS)

The "6"2Zn-"6"2Cu generator system is one of the few which yield a pure positron emitting daughter. The authors have developed a method for the preparation of this generator system following 32 MeV #alpha# particle bombardment of nickel targets. The chemical processing involves two stages: first a hydrous zirconium oxide column is used at pH 4-5 to separate the zinc and copper activities produced in the target nickel, and secondly, a conventional anion exchange column is used to retain the "6"2Zn and remove all copper activities in 2M HCl. This column serves as the "6"2Cu generator which will yield pure "6"2Cu repeatedly, free from "6"2Zn and other impurities, in a mixture of HCl and NaCl. A method is outlined also to obtain a solution of "6"2Zn using the hydrous zirconium oxide (HZO) column. "6"1Cu can be prepared as a by-product in the above procedure, but a method for the preparation of "6"1Cu alone using an 18 MeV ...

20

Materials considerations for the National Spallation Neutron Source target  

Energy Technology Data Exchange (ETDEWEB)

The National Spallation Neutron Source (NSNS), in which neutrons are generated by bombarding a liquid mercury target with 1 GeV protons, will place extraordinary demands on materials performance. The target structural material will operate in an aggressive environment, subject to intense fluxes of high energy protons, neutrons, and other particles, while exposed to liquid mercury and to water. Components that require special consideration include the Hg liquid target container and protective shroud, beam windows, support structures, moderator containers, and beam tubes. In response to these demands a materials R and D program has been developed for the NSNS that includes: selection of materials; calculations of radiation damage; irradiations, post irradiation testing, and characterization; compatibility testing and characterization; design and implementation of a plan for monitoring of materials ...

1997-08-01

21

Turnover of texture in low rate sputter-deposited nanocrystalline molybdenum films  

International Nuclear Information System (INIS)

The crystallite size and orientation in molybdenum films prepared by magnetron sputtering at a low rate of typical 1 (angstrom)s and a pressure of 0.45 Pa was investigated by X-ray diffraction and texture analysis. The surface topography was studied using atomic force microscopy. Increasing the film thickness from 20 nm to 3 microm, the films show a turnover from a (110) fiber texture to a (211) mosaic-like texture. In the early state of growth (20 nm thickness) the development of dome-like structures on the surface is observed. The number of these structures increases with film thickness, whereas their size is weakly influenced. The effect of texture turnover is reduced by increasing the deposition rate by a factor of six, and it is absent for samples mounted above the center of the magnetron source. The effect of texture turnover is related to the bombardment of the films with high energetic argon neutrals resulting from backscattering at the ...

1997-04-04

22

Production of high-q ions by laser bombardment method  

International Nuclear Information System (INIS)

The expanding plasma produced when an intense pulse of laser radiation is focused in vacuum onto a solid target has been used as a source of highly stripped ions for collision cross-section measurements. Usable fluxes of carbon nuclei at energies of a few hundred eV/charge have been obtained by irradiation of graphite with pulses of CO"2 laser radiation at a focused power density of 3 x 10_1_0 W/cm_2. Bombardment of aluminum and iron targets at comparable power levels have yielded ions of maximum charges of 9 and 16 respectively. A time-of-flight apparatus has been constructed to utilize the laser source for measurement of electron capture cross sections for highly stripped ions in gases at energies in the few hundred eV/charge range. Apertures collimate an ion beam from the plasma blowoff, and an electrostatic analyzer selects ions from the expanding plasma which have the same energy per charge. The beam is directed ...

1981-01-01

23

Energy and angular distributions of neutrons from 90-MeV proton and 140-MeV alpha-particle bombardment of nuclei  

Energy Technology Data Exchange (ETDEWEB)

Neutron time-of flight spectra were measured from 90 MeV protons and 140 MeV alpha-particle bombardment of Al, Ni, Zr, and Bi at laboratory angles between 20/sup 0/ and 130/sup 0/. The proton induced neutron spectra reveal three distinct energy regions; a low energy evaporation region, a high-energy region dominated by quasi-free scattering processes and an intermediate-energy region dominated by multi-step, pre-equilibrium processes. In the latter two regions, the spectra show strong angular dependence. The alpha-induced neutron spectra show these same distinct energy regions plus an exponential fall-off above the beam energy per nucleon. The high-energy portions of the forward-angle neutron and proton cross sections are in ratios consistent with the assumption that single nucleon-nucleon scattering dominates. For heavy-mass targets, the low-energy evaporation regions show neutron yields larger than proton yields. The proton-to-neutron ratios ...

1982-01-01

24

Energy and angular distributions of neutrons from 90-MeV proton and 140-MeV alpha-particle bombardment of nuclei  

International Nuclear Information System (INIS)

Neutron time-of flight spectra were measured from 90 MeV protons and 140 MeV alpha-particle bombardment of Al, Ni, Zr, and Bi at laboratory angles between 20"0 and 130"0. The proton induced neutron spectra reveal three distinct energy regions; a low energy evaporation region, a high-energy region dominated by quasi-free scattering processes and an intermediate-energy region dominated by multi-step, pre-equilibrium processes. In the latter two regions, the spectra show strong angular dependence. The alpha-induced neutron spectra show these same distinct energy regions plus an exponential fall-off above the beam energy per nucleon. The high-energy portions of the forward-angle neutron and proton cross sections are in ratios consistent with the assumption that single nucleon-nucleon scattering dominates. For heavy-mass targets, the low-energy evaporation regions show neutron yields larger than proton yields. The proton-to-neutron ratios observed ...

25

SiO{sub 2}-Ta{sub 2}O{sub 5} sputtering yields: simulated and experimental results  

Energy Technology Data Exchange (ETDEWEB)

To improve mirrors coating, we have modeled sputtering of binary oxide targets using TRIM code. First, we have proposed a method to calculate TRIM input parameters using on the one hand thermodynamic cycle and on the other hand Malherbe`s results. Secondly, an iterative processing has provided for oxide steady targets caused by ionic bombardment. Thirdly, we have exposed a model to get experimental sputtering yields. Fourthly, for (Ar - SiO{sub 2}) pair, we have determined that steady target is a silica one. A good agreement between simulated and experimental yields versus ion incident angle has been found. For (Ar - Ta{sub 2} O{sub 5}) pair, we have to introduce preferential sputtering concept to explain discrepancy between simulation and experiment. In this case, steady target is tantalum monoxide. For (Ar - Ta+O{sub 2}) pair, tantalum sputtered by argon ions in reactive oxygen ...

1994-09-01

26

Spectroscopy of neutron-rich {sup 59-63}Mn isotopes  

Science.gov (United States)

The neutron-rich Mn isotopes from A=59 to 63 have been studied through multi-nucleon transfer reactions by bombarding a {sup 238}U target with a beam of {sup 70}Zn at an energy of E{sub lab}=460 MeV. Prompt {gamma} rays measured by the CLARA array have been identified unambiguously for each nucleus, using coincidence relationships with ions detected in the high-acceptance magnetic spectrometer PRISMA. The new data extends the knowledge of the low-lying level structure of Mn isotopes, which is discussed in terms of the systematics of the region. Results are compared with large-scale shell-model calculations using different effective interactions and valence spaces.

2008-08-15

27

Spectroscopy of neutron-rich "5"9"-"6"3Mn isotopes  

International Nuclear Information System (INIS)

The neutron-rich Mn isotopes from A=59 to 63 have been studied through multi-nucleon transfer reactions by bombarding a "2"3"8U target with a beam of "7"0Zn at an energy of E_l_a_b=460 MeV. Prompt #gamma# rays measured by the CLARA array have been identified unambiguously for each nucleus, using coincidence relationships with ions detected in the high-acceptance magnetic spectrometer PRISMA. The new data extends the knowledge of the low-lying level structure of Mn isotopes, which is discussed in terms of the systematics of the region. Results are compared with large-scale shell-model calculations using different effective interactions and valence spaces.

2008-08-01

28

K-shell x-ray production cross sections of selected elements from Ti to Y for 0.5- to 2.5-MeV alpha-particle bombardment  

International Nuclear Information System (INIS)

K-shell x-ray production cross sections and K#beta#/K#alpha# ratios have been measured for thin targets of Ti, V, Cr, Fe, Ni, Cu, Zn, Ga, As, Se, Rb, Sr, and Y for 0.5- to 2.5-MeV alpha particles. The experimental values are compared to the nonrelativistic plane-wave Born approximation (PWBA), the binary-encounter approximation, and the PWBA with binding energy and Coulomb deflection corrections. The PWBA with corrections provides the best agreement with the experimental cross sections.

29

Ion-induced phase formation in metal-silicon systems. [Xenon ion implantation effects  

Energy Technology Data Exchange (ETDEWEB)

By using megaelectronvolt /sup 4/He ion backscattering techniques and transmission electron microscopy, the authors have investigated the interactions of ion beams with thin film structures in a number of silicide-forming systems. The mixed layer was found to be an equilibrium compound for near-noble metals and an amorphous phase for refractory metals. Differences in behavior have also been observed in near-noble metal systems. For palladium, the Pd/sub 2/Si phase grew with ion dose and remained crystalline up to high dose. For nickel, the compound Ni/sub 2/Si was formed initially and became amorphous on prolonged irradiation. All the results indicate the significance of atomic mobility at target temperatures in determining the phase formation and in explaining the sensitivity of the silicides to ion bombardment.

1985-01-11

30

Ion-induced phase formation in metal-silicon systems  

International Nuclear Information System (INIS)

By using megaelectronvolt "4He ion backscattering techniques and transmission electron microscopy, the authors have investigated the interactions of ion beams with thin film structures in a number of silicide-forming systems. The mixed layer was found to be an equilibrium compound for near-noble metals and an amorphous phase for refractory metals. Differences in behavior have also been observed in near-noble metal systems. For palladium, the Pd_2Si phase grew with ion dose and remained crystalline up to high dose. For nickel, the compound Ni_2Si was formed initially and became amorphous on prolonged irradiation. All the results indicate the significance of atomic mobility at target temperatures in determining the phase formation and in explaining the sensitivity of the silicides to ion bombardment. (Auth.).

31

Competing Shapes And Alignments In Neutron-Rich Hf Nuclei  

International Nuclear Information System (INIS)

The talk will focus on spin-dependent competition between oblate and prolate shape minima in the potential energy landscape of "1"8"0Hf (the most neutron-rich stable isotope), mediated via the alignment of valence nucleons. Results of a prompt spectroscopic study, using deep inelastic reactions with Gammasphere and CHICO, bombarding a thin "2"3"2Th target with a "1"8"0Hf beam #approx#25% above the Coulomb barrier, will be presented. Nucleon alignments in both prolate and oblate minima will be discussed, as well as the favoring of oblate collective rotation at high spins, observed through a mixing with gamma vibrations built on the prolate shape.

2008-05-12

32

Energy and angular distributions of neutrons from 90 MeV proton and 140 MeV alpha-particle bombardment of nuclei  

International Nuclear Information System (INIS)

We measured neutron time-of-flight spectra from 90 MeV protons and 140 MeV alpha particles bombarding thin targets of Al, Ni, Zr, and Bi at laboratory angles between 20_0 and 135_0. The low-energy (5 to 45 MeV) portions of the spectra were measured with 5 cm diameter by 5 cm deep NE-213 counters at 1 m flight paths with n-#betta# pulse-shape discrimination. The high-energy (35 to 150 MeV) portions of the spectra were measured with 12.7 cm diameter by 10.2 cm deep NE-102 counters at flight paths of 2.0 to 5.0 m. The proton-induced measured neutron spectra reveal three distinct energy regions: a low-energy evaporation region, a high-energy region dominated by the quasifree scattering process, and an intermediate-energy region dominated by multistep, preequilibrium processes. In the latter two regions, the spectra show strong angular dependence. The alpha-particle induced neutron spectra show these same distinct energy regions plus an exponential ...

33

Sequential separation of carrier free {sup 52,56}Mn, {sup 55,56,58}Co and {sup 56,57}Ni from {alpha}-particle activated iron with triisooctylamine  

Energy Technology Data Exchange (ETDEWEB)

A radiochemical charged particle activation procedure for production and separation of carrier free {sup 52,56}Mn, {sup 55,56,58}Co and {sup 56,57}Ni has been developed. The radioisotopes produced on bombardment of an iron foil target with a 40 MeV {alpha}-particle beam through the nuclear reactions, Fe({alpha}, {alpha}pxn){sup 52,56}Mn, Fe({alpha}, pxn){sup 55,56,58}Co and Fe({alpha}, nx){sup 56,57}Ni, have been separated by LLX. The target element and the activation products have been sequentially separated from an HCl medium using diethylether and the liquid anion exchanger, TIOA, as extractants. Extent of separation and purity of the carrier free radiotracers at different stages of their LLX separation have been verified by taking recourse to {gamma}-ray spectrometry. (Author).

1996-04-01

34

Modeling jet penetration in glass  

Energy Technology Data Exchange (ETDEWEB)

It is well known that composite armors, consisting of glass elements confined with metallic tampers, are extraordinarily effective against shaped charge attack. Early experiments showed that jets fired against glass targets appeared to be bombarded by tiny fragments that destroyed alignment and reduced residual jet penetration. This result was attributed to an elastic rebound effect in which the outward radial motion of the target around the jet periphery was supposed to be arrested by tensile hoop stresses which developed behind the divergent shock front. Glass fragments were then accelerated radially inward and these destabilized the jet. To sustain the large tensile hoop stresses required, the glass must not have been fractured by the initial shock, behind which the stress state is typically well above the Hugoniot elastic limit. Modeling the penetration of a jet into glass requires not only determining the spall ...

1990-04-05

35

Lubrication properties of molybdenum disulfide films deposited by RF sputtering method  

Energy Technology Data Exchange (ETDEWEB)

A radio frequency sputtering apparatus with a pair of targets has been developed for depositing a film of uniform thickness onto a complex-geometric specimen such as the retainer of a ball bearing. The deposition characteristics of the apparatus were compared with those of the conventional sputtering apparatus. Lubrication properties of MoS/sub 2/ films made by these devices were also compared under a variety of conditions. Finally, friction and wear of MoS/sub 2/ films applied to angular-contact type ball bearings of 20 mm bore were studied in air, nitrogen and vacuo. The two-target sputtering has an advantage mentioned above. However, the films deposited by the method exhibited a rather short wear life because of the temperature rise of the substrate during ion bombardment and during the sputtering process. This temperature dependence was observed in films on those substrates that had been heated with a built-in heater ...

1986-01-01

36

Ion-induced M X-ray emission from heavy lanthanides  

Energy Technology Data Exchange (ETDEWEB)

Thick targets of several heavy lanthanide (Ho-Lu) compounds were bombarded by protons and /sup 3/He ions of 3 MeV/amu, and M/sub ..cap alpha../ and M/sub ..beta../ X-rays were measured with a crystal spectrometer. Ionization probabilities of the N-shell for zero impact parameter were obtained from the X-ray intensity ratio for proton and /sup 3/He ion impacts. A shell dependence of the ionization probability was found in a scaling plot. X-ray spectra of lanthanide compounds were compared and no chemical effect was observed. This result is considered to be due to the fact that the main component of M/sub ..cap alpha../ and M/sub ..beta../ lines is for radiative transition after the refilling of the 4f orbit (3d/sup -1/4f/sup n+1/ -> 4f/sup n/) where n denotes the number of 4f electrons of the target atom before ionization.

1987-12-01

38

Reactive magnetron sputtering of hard Si-B-C-N films with a high-temperature oxidation resistance  

International Nuclear Information System (INIS)

Based on the results obtained for C-N and Si-C-N films, a systematic investigation of reactive magnetron sputtering of hard quaternary Si-B-C-N materials has been carried out. The Si-B-C-N films were deposited on p-type Si(100) substrates by dc magnetron co-sputtering using a single C-Si-B target (at a fixed 20% boron fraction in the target erosion area) in nitrogen-argon gas mixtures. Elemental compositions of the films, their surface bonding structure and mechanical properties, together with their oxidation resistance in air, were controlled by the Si fraction (5-75%) in the magnetron target erosion area, the Ar fraction (0-75%) in the gas mixture, the rf induced negative substrate bias voltage (from a floating potential to -500 V) and the substrate temperature (180-350 deg. C). The total pressure and the discharge current on the magnetron target were held constant at 0.5 Pa and 1 A, respectively. The ...

2005-11-01

39

Preparation, properties, and application characteristics of metastable layers of the Ti-Si-C-N system; Herstellung, Aufbau, Eigenschaften und Anwendungsverhalten von metastabilen Schichten aus dem System Ti-Si-C-N  

Energy Technology Data Exchange (ETDEWEB)

In the Ti-Si-C and Ti-Si-C-N systems, metastable layers were precipitated by means of non-reactive magnetron sputtering of hot-pressed two-phase TiC/SiC and TiN/SiC targets with 20 mole% and 50 mole% SiC. The preparation parameters were varied as follows: ion bombardment during precipitation (bias sputtering), substrate temperature, and annealing times when annealing amorphous 50%:50% TiC/SiC and 50%:50% TiN/SiC layers. Sputtering of targets containing 20% SiC was found to result in monophase fcc layers (NaCl structure). This was documented on the basis of X-ray and electron diffraction patterns. Direct precipitation of targets with 50 mole% SiC resulted in amorphous layers. Increasing the ion bombardment during accretion, raising the substrate temperature, and annealing amorphous 50%:50% TiC/SiC and 50%:50% TiN/SiC (layers precipitated directly) resulted in the crystallization of ...

1992-10-01

40

Charged particle spectra: 140 MeV #alpha# particle bombardment of "2"7Al, "5"8Ni, "9"0Zr, "2"0"9Bi, and "2"3"2Th  

International Nuclear Information System (INIS)

Complete energy spectra and angular distributions of the light charged particles (A < or = 4) were measured for the bombardment of "2"7Al, "5"8Ni, "9"0Zr, "2"0"9Bi, and "2"3"2Th with 140 MeV #alpha# particles. The spectral shapes of a given emitted particle are very similar for all target nuclei except in the region of the evaporation peak. The slopes of the energy spectra in the forward direction become steeper as the mass of the observed particle decreases and vary very rapidly with angles. The experimental data can be characterized by compound nuclear evaporation processes at low energies, or at backward angles, and by direct reactions, nonequilibrium components and projectile breakup processes at high energies and forward angles. The breakup cross section for #alpha# particles is found to be appreciable. The total yield of light charged particles is approximately a factor approx. 2 to 3 larger than the total reaction cross section for ...

41

Contribution to the study of sputtering and damage of uranium dioxide by fast heavy ions; Contribution a l'etude de la pulverisation et de l'endommagement du dioxyde d'uranium par les ions lourds rapides  

Energy Technology Data Exchange (ETDEWEB)

Swift heavy ion-solid interaction leads in volume to track creation and on the surface to the ejection of particles into the vacuum. To learn more about initial mechanisms of track formation, we are focused on the sputtering of uranium dioxide by fast heavy ions. This present study is exclusively devoted to the influence of the electronic stopping power on the emission of neutral particles and especially on their angular distribution. These measurements are completed by those of the ions emitted from UO{sub 2} targets bombarded with swift heavy ions. The whole experimental results give access to: i) the nature of the sputtered particles; ii) the charge state of the emitted particles; iii) the direction of ejection of the sputtered particles ; iv) the sputtering yields deduced from the angular distributions. These results are compared to the prediction of the sputtering models proposed in the literature and it seems that the supersonic gas flow ...

2001-03-01

42

"1"5"8Tm and "1"5"6Tm decays  

International Nuclear Information System (INIS)

These experiments were performed on the Isocele separator, on-line with the Orsay synchrocyclotron; thulium isotopes were produced by bombarding natural erbium targets with 150nA beam of 157MeV protons. Two Ge(Li) detectors, with resolution of 2.3 and 2.5keV at 1332keV used for #gamma#-ray measurements; conversion electron spectra were measured using a Si(Li) detector. #gamma# spectra, #gamma#-#gamma# coincidence and conversion electron measurements were sufficient to build the flow energy level schemes of the transitional "1"5"8Er and "1"5"6Er nuclei. On both nuclei several quasi rotational bands have been identified. These results are compared with other even erbium isotopes and with the neighboring N=88 and 90 isotones. Comparisons with predictions issued from some classical models are also performed: "1"5"8Er appears as a deformed nucleus very similar to "1"6"0Er and "1"6"2Er; on the other hand "1"5"6Er seems to be a soft vibrational ...

1976-01-01

43

Separation of "2"0"3Pb from Tl_2O_3 target material using a hydrous zirconium oxide column with application to "2"0"1Tl preparation  

International Nuclear Information System (INIS)

Lead 203 has been used as a tracer for lead in the field of nuclear medicine for several years. It is produced in a cyclotron usually by proton or deuteron bombardment of a thallium target principally by the p,n or d,2n reaction on "2"0"3Tl or the p,3n or d,4n reaction on "2"0"5Tl. Several different methods have been reported for the separation of "2"0"3Pb from the thallium target. These generally involve a combination of precipitation and solvent extraction techniques. A new method has been developed for the separation of Pb from Tl using ion exchange chromatography over hydrous zirconium oxide (HZO). Lead is taken up by this inorganic ion exchanger at pH > 3 whereas Tl(I) is not. Lead can subsequently be eluted with acid of pH 1-1.5. The recovery of "2"0"3Pb has been approximately 75% and the Tl impurity level has not been in excess of 10 ppm. Reference is made to the application of this separation method to the ...

44

Particle emission from low energy nuclear reactions in solids. Preliminary results  

Energy Technology Data Exchange (ETDEWEB)

TiH{sub 2} and TiD{sub 2} thick targets were bombarded with 100 to 200 keV protons or deuterons. Evidence for nuclear reactions was obtained by means of a surface barrier particle detector. Deuteron irradiation of TiD{sub 2} produced these observations: copious {approx}2.5 MeV neutrons and {approx}3 MeV protons from direct D-D reactions; gamma rays from p,{gamma} and n,{gamma} reactions; {approx}14 MeV protons from the secondary d({sup 3}He, p){alpha} reaction; and a signal between {approx}6-12 MeV that Kasagi et al. has tentatively identified as protons from the fusion of three deuterium nuclei. However, this signal has in it a strong interference signal from either neutrons or gamma rays that directly deposit energy in the detector. This interference spectra was measured by placing a thick absorber in front of the detector that stops up to 20 MeV protons, but not gamma rays or neutrons. More experiments must be done before we can confirm or ...

2000-07-01

46

{sup 48}Ti(n,xnpa{gamma}) reaction cross sections using spallation neutrons for E{sub n} = 1 to 20 MeV  

Energy Technology Data Exchange (ETDEWEB)

{gamma}-ray excitation functions have been measured for the interaction of fast neutrons with {sup 48}Ti (neutron energy from 1 MeV to 250 MeV). The Los Alamos National Laboratory spallation neutron source, at the LANSCE/WNR facility, provided a ''white'' neutron beam which is produced by bombarding a natural W target with a pulsed proton beam. The prompt-reaction {gamma} rays were measured with the large-scale Compton-suppressed Ge spectrometer, GEANIE. Neutron energies were determined by the time-of-flight technique. Excitation functions were converted to partial {gamma}-ray cross sections, taking into account the dead-time correction, the target thickness, the detector efficiency, and neutron flux (monitored with an in-line fission chamber). The data analysis is presented here for neutron energies between 1 to 20 MeV. Partial {gamma}-ray cross sections for transitions in {sup 47,48}Ti, ...

2005-01-06

47

Propagation of Surface Ripples on Pyrochlore Single Crystals Induced by Ion Beam Bombardment  

Energy Technology Data Exchange (ETDEWEB)

The morphological evolution of ripples formed on the surface of Cd2Nb2O7 pyrochlore single crystals by focused ion beam (FIB) bombardment was investigated using in situ electron microscopy. At high ion fluences and off-normal bombardment angles, faceted surface ripples with a terrace-like structure were observed. The ripple propagation direction was oriented along the projected ion beam direction at incident angles ranging from 35 to 65 following high-dose ion bombardment. One side of the terrace was found to be perpendicular to the incident ion beam direction, while the other side was parallel to the ion beam. The terrace propagation velocity and direction were determined and interpreted on the basis of this asymmetric structure. A model based on the propagation of a shock wave that effectively self-selects a stable slope, was developed in order to explain the observed faceted ripple formation.

2009-08-01

48

Non-equilibrium particle emission in 45 MeV #alpha# particle bombardment of "1"5"9Tb  

International Nuclear Information System (INIS)

Mar 1982. p. 36-37. Germany Didelez, JP Paris-11 Univ., 91 - Orsay (France).

1982-03-01

49

The present status of astatine chemistry  

International Nuclear Information System (INIS)

24 isotopes of astatine element 85, are known today, three of which occur naturally as decay products of "2"1"5U and "2"5"8U, respectively. Because these isotopes being very short-lived, all experiments dealing with this heaviest element of the halogen group need be done with "2"0"9"-"2"1"1At, having half-lifes in the several hours region. Mixtures of them may be obtained either by #alpha#-bombardment (E#alpha# approximately 30-50 MeV) of "2"0"9Bi or as spallation products by the reaction of high-energy protons with thorium and uranium targets. - In its chemical reactions astatine shows a behaviour which is between an halogen and a metal. The following oxidation states have been shown to exist: -1, 0, +1, +5 and +7. At"-, AtO_2"- and AtO_4"- are the ionic species for At(-I), At(+V) and At(+VII) whereas no definite species have been established for the other oxidation states. Furthermore, At_2 could not be shown to exist as yet in contrast to ...

50

Activation cross sections of deuteron-induced nuclear reactions on hafnium  

International Nuclear Information System (INIS)

Experimental excitation functions for deuteron-induced reactions up to 20 MeV on high purity natural hafnium were measured with the activation method using a stacked foil irradiation technique. Metallic hafnium foils with thickness of 10 #mu#m were stacked together with 50 #mu#m thick aluminium and 12 #mu#m thick titanium foils. The aluminium foils served as energy absorber while the titanium foils were used to monitor the energy and intensity of the bombarding deuteron beam. From a detailed remeasurement of the complete excitation function of the "n"a"tTi(d,x)"4"8V monitor reaction it was possible to adopt the proper incident energy and beam intensity by comparing the results with the recommended values. High resolution off-line gamma-ray spectrometry was applied to assess the activity of each foil. From the measured activity independent and/or cumulative elemental or isotopic cross section data for production of Ta, Hf and Lu radioisotopes by (d,x) reactions were ...

2010-11-15

51

Spectrum measurement of neutrons from 40 MeV alpha particle bombardment of tantalum  

International Nuclear Information System (INIS)

The energy distribution of neutrons generated due to bombardment of 40 MeV alpha particles on thick elemental tantalum is measured using threshold activation detectors. A method of unfolding the neutron spectrum from the activation data based on information-entropy weighted average solution is described. The present unfolding method does not require 'a priori' information about the shape of the solution spectrum. 16 refs. (author).

52

Determination of the thickness and density of the ion bombardment induced altered layer in SiC by means of reflection electron energy loss study  

International Nuclear Information System (INIS)

The steady state surfaces of ion bombarded 3C-, 4H- and 6H-SiC samples were studied by means of reflected electron energy loss spectroscopy (REELS). The REELS exhibit a well-defined loss peak in the region of about 20 eV. The position of the maximum of the loss peak depends on the bombarding ion energy (decreasing with increasing ion energy), and on the primary electron beam energy (increasing with increasing primary energy). This behavior can be explained if we suppose that the plasmon energy in the altered layer (produced by ion bombardment) is different from that of the unaltered bulk. In this case the measured loss peak is the sum of two overlapping plasmon peaks. With modeling the system as a homogeneous altered layer and a homogeneous unaltered substrate the plasmon energy in the altered layer was derived to be 19.8 eV. The large change of the plasmon energy with respect to the bulk value of 23 eV is explained by a ...

2005-12-15

54

Constraints on target chamber first wall and target designs that will enable NIF debris shields to survive  

CERN Document Server

Constraints on target chamber first wall and target designs that will enable NIF debris shields to survive

1999-01-01

55

Formation of blisters in tantalum by 30 MeV alpha particle bombardment  

Energy Technology Data Exchange (ETDEWEB)

The phenomenon of radiation blistering by helium ion bombardment has been the subject of extensive studies in recent years because of its technological importance in thermonuclear fusion devices and reactors. However, the mechanism of radiation blistering is still not well understood. There are two different models of blister formation: the gas-pressure model and the lateral stress model. The former model is, however, supported by many experimental observations, the prominent one is that of Evans and Eyre who observed blisters appearing on the front and rear surfaces of a thin wedge-shaped molybdenum foil irradiated by helium ions. Their experiment also indicates that the thickness of the irradiated specimen could be important in affecting the characteristics of blisters. With this in view, we have studied the development of blisters in thin foils of tantalum by 30 MeV ..cap alpha..-particle bombardment.

1984-08-01

56

Formation of blisters in tantalum by 30 MeV alpha particle bombardment  

International Nuclear Information System (INIS)

The phenomenon of radiation blistering by helium ion bombardment has been the subject of extensive studies in recent years because of its technological importance in thermonuclear fusion devices and reactors. However, the mechanism of radiation blistering is still not well understood. There are two different models of blister formation: the gas-pressure model and the lateral stress model. The former model is, however, supported by many experimental observations, the prominent one is that of Evans and Eyre who observed blisters appearing on the front and rear surfaces of a thin wedge-shaped molybdenum foil irradiated by helium ions. Their experiment also indicates that the thickness of the irradiated specimen could be important in affecting the characteristics of blisters. With this in view, we have studied the development of blisters in thin foils of tantalum by 30 MeV #alpha#-particle bombardment. (orig.).

57

Defect creation by electronic processes in MgO bombarded with GeV heavy ions  

Energy Technology Data Exchange (ETDEWEB)

To study the defect creation induced by electronic processes in refractory oxides, MgO single crystals were irradiated with high energy tin, uranium and lead ions. Optical absorption measurements showed that F-type centers (oxygen vacancies with trapped electrons) were created during irradiation. The total number of centers per unit area of bombarded sample increases linearly with irradiating fluence. The main part of the point defects was found to arise from electronic processes. The concentration of F-type centers induced by ionization increases with the electronic energy losses. Assuming a saturation of point defect concentration at high fluences, F-type center creation cross sections could be estimated. The influence of irradiation temperature and of the velocity of the bombarding ions are discussed.

1996-12-31

59

A shockproof container for the transport and storage of fragile or reactive target foils  

CERN Document Server

A shockproof container for the transport and storage of fragile or reactive target foils

1971-01-01

60

An influence of ion bombardment on plasma nitriding process of Ti6Al14V alloy at 843 K temperature  

International Nuclear Information System (INIS)

This work presents results of investigations on d.c. glow discharge nitriding of #alpha#+#beta# Ti-6Al-4V titanium alloy. The treatment was performed at 843 K in nitrogen-hydrogen atmosphere, pressure 300 Pa. Special attention was paid to nitriding mechanism and determination of the role of ion bombarding in nitriding process of titanium alloys. Produced as a result of d.c. plasma nitriding surface layers were subjected to macroscopic observations, microstructure studies, microhardness testing and X-ray analysis. (author)

2004-06-20

61

A study of crystalline and stress behavior in oxide films prepared by ion assisted deposition  

International Nuclear Information System (INIS)

One of the main problems related to optical thin film materials used in high power laser environments is the catastrophic damage caused to them due to laser irradiation. While the influence of ion bombardment on the optical properties of oxide thin films is now a well understood subject, the morphology and crystalline behaviour of these films under ion incidence is not so well studied. Hence, it is of great importance to investigate the effects of ion bombardment during growth on the microstructure and crystalline behaviour of oxide materials.

1994-10-24

65

Computational Challenges in miRNA Target Predictions: To Be or Not to Be a True Target?  

UK PubMed Central (United Kingdom)

All microRNA (miRNA) target—finder algorithms return lists of candidate target genes. How valid is that output in a biological setting? Transcriptome analysis has proven to be a useful approach...Full Text Available

2009-01-01

66
67

The energy dependence of L_#alpha#/L_l X-ray intensity ratio produced by heavy-ion bombardment  

International Nuclear Information System (INIS)

The energy dependence of the Yb and Au L_#alpha#/L_l X-ray intensity ratio, produced by 0.5 - 3.0 MeV/u Li, Be, C, N, F, and Si ion bombardment (Malhi and Gray, Phys. Rev. A 44, 7199, (1991)), measured at 90"0 relative to the beam axis, has been explained. While for light ion impact the behaviour of the alignment parameter as a function of impact velocity is dominant, for the impact of heavier ions the multiple ionization effects become important. Using Larkins' prescription in the last case, calculations have been performed, which agree well with the data over the whole energy range investigated. (Author).

1993-01-01

68

Single phase polycrystalline metastable (GaSb)/sub 1-x/Ge/sub x/ alloys from annealing of amorphous mixtures: Ion mixing effects during deposition  

International Nuclear Information System (INIS)

Low energy (<100 eV) Ar"+ ion bombardment of the growing film during the deposition of amorphous GaSb+Ge mixtures was found to affect both the transformation rate kinetics as well as the reaction path during subsequent annealing. Ion bombardment induced collisional cascades resulted in more random mixing in the growing films thus retarding the rate of the amorphous to equilibrium state phase transformation during annealing and allowing the formation of homogeneous metastable randomly oriented single phase (GaSb)/sub 1-x/Ge/sub x/ alloys. The films were approx.1.5 #mu#m thick and the average grain size in the metastable state was approx.300 A.

6180-01-01

69

Mechanical properties of SiAlON glass surface after swift heavy-ion bombardment  

International Nuclear Information System (INIS)

A Y-Mg-Si-Al-O-N glass was submitted to swift heavy-ion bombardment at GANIL (Caen, France) and the influence of irradiation on the mechanical properties was studied. The mechanical properties of the glass were characterized both before and after irradiation. Changes in hardness, elastic modulus and fracture toughness of the near-surface irradiated layer were determined using indentation techniques. SRIM calculations allowed to estimate the ions penetration range and the energy deposition relative to electronic and nuclear interactions, which can be correlated to the experimental damaged depth. Meyer's hardness and Young's modulus decrease by about 30 %, while fracture toughness is increased by more than 40 %. (authors)

70

Low-lying states of {sup 109}Sn from the {sup 106}Cd({alpha},n{gamma}) reaction  

Energy Technology Data Exchange (ETDEWEB)

Measurements of {gamma}-ray, {gamma}{gamma}-coincidence and internal conversion electron spectra from the {sup 106}Cd({alpha},n{gamma}){sup 109}Sn reaction were carried out at 15-20 MeV {alpha}-particle bombarding energies with Ge(HP) {gamma}-ray and superconducting magnetic lens plus Si(Li) electron spectrometers. The energies, relative intensities, internal conversion coefficients and coincidence relations of the {sup 109}Sn transitions were determined, and a more complete, consistent level scheme has been deduced. Spin and parity values have been determined from the internal conversion coefficients, the bombarding-energy dependence of the side-feeding intensities of the states and the available {gamma}-ray angular distribution data. The level scheme was interpreted in the framework of the quasi-particle shell model.

1999-02-01

71

A study of the effects of MeV alpha particles in PE and PVDC  

Energy Technology Data Exchange (ETDEWEB)

We have mapped and studied the effects of MeV alpha-particle bombardment in polyvinylidene chloride (PVDC) and polyethylene (PE). We used 3.5 and 5.0 MeV alpha-particle incident beams and stacked polymer films to separate the contributing effects of the electronic ({var_epsilon}{sub e}) and nuclear ({var_epsilon}{sub n}) stopping powers. The electrical conductance and change in the chemical structures were measured by direct resistivity measurement, Raman microprobe, RBS and FTIR. The results indicate significant differences in the ({var_epsilon}{sub e}) and ({var_epsilon}{sub n}) effects at higher alpha-particle bombardment fluences. {copyright} {ital 1997 American Institute of Physics.}

1997-02-01

72

Light emission from grazing incidence interaction of light ions with clean Cu(110)  

International Nuclear Information System (INIS)

Photon yields were measured from Cu(110) bombarded by H"+, H_2"+ and He"+ with different energies. The energy dependence is different from previous studies at perpendicular incidence. A calculation of the energy dependence of resonant charge capture into the n=3 state of H is compared with experiment. (G.Q.).

1983-02-04

73

LIQUID NITROGEN CRYOSTAT TO FACILITATE ISOTHERMAL ANNEALING STUDIES ON METALS AFTER HEAVY-PARTICLE BOMBARDMENT  

Science.gov (United States)

A cryostat is described that was developed for irradiating a number of small metal specimens with a high beamcurrent of heavy particles at liquid nitrogen temperature. The specimens, which are mounted on a block, are taken out of the cryostat after irradiation and subsequently annealed in a temperature bath. The progress of annealing is followed by measuring the change in electrical resistivity of the specimens in liquid helium. (auth)

1964-01-01

74

L-subshell ionisation of [sub 71]Lu, [sub 73]Ta and [sub 79]Au by 1. 5-4. 5 MeV alpha particles  

Energy Technology Data Exchange (ETDEWEB)

The L X-rays of [sub 71]Lu, [sub 73]Ta and [sub 79]Au were produced by 1.5-4.5 MeV alpha particle bombardment. The emitted L[sub [alpha

1992-11-01

75

Flucton - becoming and development of the conception  

International Nuclear Information System (INIS)

Effect of proton backscattering on inelastic pd-scattering is discussed in detail. The discussion was carried out on the basis of interaction mechanism if bombarding particle with flucton. It is noted that fluctons are assumed presently as time multiquark formations of nuclear matter with the size of nucleon size order and density above nucleon one. 35 refs., 10 figs.

1993-01-27

76

EXCITATION OF ISOBARIC ANALOG STATES IN $sup 89$Y AND $sup 90$Zr  

Science.gov (United States)

The excitation of compound-nucleus resonances in Y/sup 89/ and Zr/sup 90/ by proton bombardment at 4 to 5.5 Mev of Sr/sup 88/ and Y/sup 89/, respectively, is reported. Shell-model corfigurations were used to interpret the results. (R.E.U.)

1964-02-24

77

Cumulative kaon production by 10 GeV protons  

International Nuclear Information System (INIS)

The K"+- and K"-meson cumulative production cross sections are measured at 119"0 in the laboratory system on nuclei Be, Al, Cu and Ta bombarded by 10 GeV protons. Spectra of the K"-mesons consisting of only sea quarks show universal features characteristic of the spectra of cumulative particles, which contain valence quarks. Evidence is obtained for the fact that the energy density in a flucton can exceed the mean nuclear density by an order of magnitude.

78

Calculation of the imaginary part of the heavy ion potential  

Energy Technology Data Exchange (ETDEWEB)

The paper contains a numerical evaluation of the expressions for the absorptive potential in heavy ion reactions given earlier. With a standard folding expression for the real part of the ion-ion potential general good agreement is found with experimental data for the angular distributions of elastic and inelastic scattering. Special interest is attached to the case of /sup 16/O + /sup 28/Si where the calculated imaginary potential is very small at low bombarding energies.

1983-09-19

79

Calculation of the imaginary part of the heavy ion potential  

International Nuclear Information System (INIS)

The paper contains a numerical evaluation of the expressions for the absorptive potential in heavy ion reactions given earlier. With a standard folding expression for the real part of the ion-ion potential general good agreement is found with experimental data for the angular distributions of elastic and inelastic scattering. Special interest is attached to the case of "1"6O + "2"8Si where the calculated imaginary potential is very small at low bombarding energies. (orig.).

80

Boron profiles in amorphous and crystalline silicon  

Energy Technology Data Exchange (ETDEWEB)

The resonance reaction /sup 11/B(p,/alpha/)/sup 8/Be was used to determine the boron profiles in the surface of: (1) boron implanted silicon; (2) boron diffused silicon; and (3) boron containing films deposited on silicon wafers. The boron distribution in the various samples was found to be stable under the bombardment of the proton beam. The convolution process used to obtain yield curves from the depth distribution, and the program used for this purpose are described.

1989-01-01

81

Targeting Prostate Cancer Cells In Vivo Using a Rapidly Internalizing Novel Human Single-Chain Antibody Fragment  

UK PubMed Central (United Kingdom)

Human antibodies targeting prostate cancer cell surface epitopes may be useful for imaging and therapy. The objective of this study was to evaluate the tumor targeting of an internalizing human...Full Text Available

2010-03-01

83

Isoform-level microRNA-155 target prediction using RNA-seq  

UK PubMed Central (United Kingdom)

Computational prediction of microRNA targets remains a challenging problem. The existing rule-based, data-driven and expression profiling approaches to target prediction are mostly approached from the...Full Text Available

2011-05-01

84

Delineating Bacteriostatic and Bactericidal Targets in Mycobacteria Using IPTG Inducible Antisense Expression  

UK PubMed Central (United Kingdom)

In order to identify novel high value antibacterial targets it is desirable to delineate whether the inactivation of the target enzyme will lead to bacterial death or stasis. This knowledge is particularly...Full Text Available

85

A thermal hydraulic investigation on ADSR liquid lead target  

Energy Technology Data Exchange (ETDEWEB)

Computational fluid dynamics(CFD) code FLUENT was used to simulate the thermal hydraulic processes occurring in conceptual design of the accelerator-driven subcritical reactor(ADSR) liquid lead target. The purpose of the analysis is to investigate the thermal hydraulic characteristics of liquid lead as ADSR target material with various target geometries and injection locations of proton beam. In the calculation analysis, the local temperature of the liquid lead target rises to the boiling temperature very rapidly. When the proton beam is injected from the bottom of the target system, the duration time to reach the boiling temperature is longer and the temperature distribution is flatter than other cases.

1998-05-01

86

The response of small scale rigid targets to shallow buried explosive detonations  

British Library Electronic Table of Contents (United Kingdom)

Experimental and computational investigations were performed in order to better understand the mechanical response of rigid targets with various geometries to the detonation of shallow buried explosives. The motion of the targets was measured by use of high-speed digital video photography. This work involved flat targets, targets that were downwardly convex, and targets that were downwardly concave with explosive charges located at various positions beneath the targets. It was observed that, in general, angled hulls - whether downwardly concave or convex - tended to reduce the amount of momentum imparted to the center of mass of the targets. Computations were performed by use of an arbitrary Langrangian-Eulerian treatment in a nonlinear finite element code. A model based on quasi-static te...

2011-01-01

87

Targeting a Ruthenium Complex to the Nucleus with Short Peptides  

UK PubMed Central (United Kingdom)

In an effort to develop octahedral metal complexes as chemotherapeutic and diagnostic agents targeted to DNA, it is critical to optimize the properties of their cellular uptake. Appending d-octaarginine...Full Text Available

2010-05-15

88

Target stations and beam dumps for the CERN SPS  

International Nuclear Information System (INIS)

The design of the absorber blocks for internal and external dumping of the SPS proton beam is discussed. In addition, the external target stations for slow and fast extracted proton beams are described.

1977-03-16

89

Suitability of a New Plant Invader as a Target for Biological Control in Florida  

Science.gov (United States)

... L. Sutton. 2000. Is the aquatic weed hygrophila, Hygrophila polysperma (Polemoniales: Acanthaceae), a suitable target for classical biological ... ...

90

Nato SCI-12 on Camouflage Evaluation Workshop on Search and Target ...  

Science.gov (United States)

Nato SCI-12 on Camouflage Evaluation Workshop on Search and Target Acquisition The Netherlands, June 1999. Image Discrimination Models for Object Detection ...

91

FOR THIN AND THICK TARGETS - NASA Technical Report Server (NTRS)  

Science.gov (United States)

By W. Wayne Scott. Langley Research Center. SUMMARY. Thin- and thick-target bremsstrahlung spectra are presented for electron energies up to 7.0 MeV. ...

92

Target area chamber system design for the National Ignition Facility  

International Nuclear Information System (INIS)

The National Ignition Facility (NIF) is a proposed Department of Energy facility which will contribute to the resolution of important Defense Program and inertial fusion energy issues for energy production in the future. The NIF will consist of a laser system with 192 independent beamlets transported to a target chamber. The target chamber is a multi-purpose structure that provides the interface between the target and the laser optics. The chamber must be capable of achieving moderate vacuum levels in reasonable times; it must remain dimensionally stable within micron tolerances, provide support for the optics, diagnostics, and target positioner; it must minimize the debris from the x-ray and laser light environments; and it must be capable of supporting external neutron shielding. The chamber must also be fabricated from a low neutron activation material. The fusion reaction in the ...

1994-06-19

93

{sup 35}Cl + {sup 12}C asymmetrical fission excitation functions  

Energy Technology Data Exchange (ETDEWEB)

The fully energy-damped yields from the {sup 35}Cl + {sup 12}C reaction have been systematically investigated using particle-particle coincidence techniques at a {sup 35}Cl bombarding energy of {approx} 8 MeV/nucleon. The fragment-fragment correlation data show that the majority of events arises from a binary-decay process with rather large numbers of secondary light-charged particles emitted from the two excited exit fragments. No evidence is observed for ternary breakup events. The binary-process results of the present measurement, along with those of earlier, inclusive experimental data obtained at several lower bombarding energies are compared with predictions of two different kinds of statistical model calculations. The methods give comparable predictions and are both in good agreement with the experimental results thus confirming the fusion-fission origin of the fully-damped yields. (author). 39 refs. Submitted to Physical Review, C (US).

1996-04-01

94

Radiation-induced segregation in light-ion bombarded Ni-8% Si  

Energy Technology Data Exchange (ETDEWEB)

Tensile specimens 60 ..mu..m thick of Ni-8 at. % Si have been bombarded at 475/sup 0/C to doses of 0.1 to 0.3 dpa with either 7 MeV proton or 28 MeV alpha particle beams. Deliberate embrittlement by high temperature (700/sup 0/C) preimplantation of helium was required to produce intergranular fracture. Depth profile sputtering and analysis in a Scanning Auger Microprobe was then used to study radiation-induced segregation of silicon both at the external surfaces and at internal interfaces. The external surfaces exhibited a strongly silicon-enriched zone for the first 10 to 20 nm followed by a broad (approx.200 nm), shallow silicon-depleted region. Segregation of silicon to grain boundaries varied from interface to interface and possibly from region to region on a given interface. In general, however, depth profiles of silicon content with distance from internal boundaries showed no noticeable depletion zone and a more gradual fall-off compared to the profiles from ...

1986-01-01

95

Depth profiling using C{sub 60} {sup +} SIMS-Deposition and topography development during bombardment of silicon  

Energy Technology Data Exchange (ETDEWEB)

A C{sub 60} {sup +} primary ion source has been coupled to an ion microscope secondary ion mass spectrometry (SIMS) instrument to examine sputtering of silicon with an emphasis on possible application of C{sub 60} {sup +} depth profiling for high depth resolution SIMS analysis of silicon semiconductor materials. Unexpectedly, C{sub 60} {sup +} SIMS depth profiling of silicon was found to be complicated by the deposition of an amorphous carbon layer which buries the silicon substrate. Sputtering of the silicon was observed only at the highest accessible beam energies (14.5 keV impact) or by using oxygen backfilling. C{sub 60} {sup +} SIMS depth profiling of As delta-doped test samples at 14.5 keV demonstrated a substantial (factor of 5) degradation in depth resolution compared to Cs{sup +} SIMS depth profiling. This degradation is thought to result from the formation of an unusual platelet-like grain structure on the SIMS crater bottoms. Other unusual topographical features were also ...

2006-07-30

96

Target R and D at JAERI  

Energy Technology Data Exchange (ETDEWEB)

We proposed a solid and a mercury target concepts through the preliminary conceptual design. To feasible these concepts, analysis and experimental works are being carried out. This paper introduces an outline of present status of target R and D such as heat transfer augmentation experiments for the solid target, mercury flow tests with a loop of maximum flow rate of 15L/min, flow pattern measurements for a cold source moderator etc. as well as preliminary conceptual design works. (author)

1999-03-01

101

A He-gas Cooled, Stationary Granular Target  

CERN Document Server

In the CERN approach to the design of a neutrino factory, the repetition frequency of the proton beam is high enough to consider stationary solid targets as a viable solution for multi-MW beams. The target consists of high density tantalum spheres of 2 mm diameter which can efficiently be cooled by passing a high mass flow He-gas stream through the voids between the Ta-granules. Very small thermal shocks and stresses will arise in this fine grained structure due to the relatively long burst of 3.3 ms from the SPL-proton linac. In a quadruple target system where each target receives only one quarter of the total beam power of 4 MW, conservative temperature levels and adequate lifetimes of the target are estimated in its very high radiation environment. A conceptual design of the integration of the target into the magnetic horn-pion-collector is presented.

2003-01-01

102

Observation of a surface peak in low energy implant depth profiles in silicon  

Energy Technology Data Exchange (ETDEWEB)

In situ Auger sputter depth profiles of saturation implants of 3 keV N/sub 2//sup +/ in silicon at room temperature exhibit a sharp peak in the nitrogen concentration in the outermost layers, followed by a monotonic decrease. No broad plateau was observed. The energy of the Auger line corresponding to the Si(2p) core electron excitation, monitored throughout the profiling, exhibits a chemical shift of up to 7 eV at the surface peak concentration. Inert gas ion post-bombardment of unsaturated implants significantly modifies the profile, and supports the suggestion that the surface peak arises through radiation enhanced diffusion of implanted atoms.

1984-03-01

103

New radioisotope for lung ventilation studies: 19-neon  

Energy Technology Data Exchange (ETDEWEB)

Neon 19, a 17-second positron-emitting radioelement, is produced continously by 23 MeV alpha particle bombardment of oxygen. For a 12 ..mu..A particle current the method of preparation described delivers 14 mCi of neon 19 per min to the functional exploration room. The radiochemically pure radioactive gas is diluted in air and breathed continously by the patient lying under a positron tomographic camera. The regional lung ventilation distribution is obtained on 2 cm thick sections of organ with a transverse resolution of 17 mm. Quantification of the ventilation output per unit lung volume is contemplated.

1980-10-01

104

From Earth to Mars in 15 days with an americium-propelled space ship; De la terre a mars en 15 jours avec un vaisseau spatial propulse a l'americium  

Energy Technology Data Exchange (ETDEWEB)

This digest paper presents the theoretical project of a fission engine for space ship as imagined by Y. Ronen from the Ben-Gourion Univ. (Israel). In this engine, the combustion chamber is covered with metastable {sup 242}Am thin sheets. The fission reaction is triggered with a bombardment of neutrons and the fission fragments ionize a gas (hydrogen, for instance) which is overheated and ejected through the engine nozzle. (J.S.)

2002-01-01

105

Field emission dark current of technical metallic electrodes  

International Nuclear Information System (INIS)

In the framework of the Low Emittance Gun (LEG) project, high gradient acceleration of a low emittance electron beam will be necessary. In order to achieve this acceleration, a -500 kV, 250 ns FWHM, pulse will be applied between two electrodes. Those electrodes should sustain the pulsed field without arcing, must not outgas and must not emit electrons. Ion back bombardment, and dark current will be damaging to the electron source as well as for the low emittance beam. Electrodes of commercially available OFE copper, aluminium, stainless steel (SS), titanium and molybdenum were tested, following different procedures including plasma glow discharge cleaning.

2007-04-21

106

Chemical effects of L X-ray intensity ratios in niobium and molybdenum compounds  

Energy Technology Data Exchange (ETDEWEB)

Chemical effects of L X-ray intensity ratios in niobium and molybdenum compounds were studied by electron and proton bombardments. L{sub {gamma}1} X-rays which involve transition of 4d electrons of the valence shell were found to be sensitive to the chemical environment. The L{sub {gamma}1}/L{sub {beta}1} X-ray intensity ratio increased with an increase of the 4d electron occupation of niobium or molybdenum in niobium or molybdenum compounds, showing that the chemical effects can be ascribed to the 4d electron behavior of the metallic atom in its compounds. (orig.).

1990-12-20

107

Chemical effects of L X-ray intensity ratios in niobium and molybdenum compounds  

International Nuclear Information System (INIS)

Chemical effects of L X-ray intensity ratios in niobium and molybdenum compounds were studied by electron and proton bombardments. L_#gamma#_1 X-rays which involve transition of 4d electrons of the valence shell were found to be sensitive to the chemical environment. The L_#gamma#_1/L_#beta#_1 X-ray intensity ratio increased with an increase of the 4d electron occupation of niobium or molybdenum in niobium or molybdenum compounds, showing that the chemical effects can be ascribed to the 4d electron behavior of the metallic atom in its compounds. (orig.).

1990-12-01

108

Variation in the Definition of Clinical Target Volumes for Pelvic Nodal Conformal Radiation Therapy for Prostate Cancer  

UK PubMed Central (United Kingdom)

PurposeWe conducted a comparative study of Clinical Target Volume (CTV) definition of pelvic lymph nodes by multiple GU radiation oncologists looking at the levels...Full Text Available

2009-06-01

109

Targeted nanoparticles that deliver a sustained, specific release of paclitaxel to irradiated tumors  

UK PubMed Central (United Kingdom)

To capitalize on the response of tumor cells to ionizing radiation, we developed a controlled-release nanoparticle drug delivery system using a targeting peptide that recognizes a radiation-induced...Full Text Available

2010-06-01

110

Targeted Deletion of Somatotroph Insulin-Like Growth Factor-I Signaling in a Cell-Specific Knockout Mouse Model  

UK PubMed Central (United Kingdom)

The role of IGF-I in the negative regulation of GH expression and release is demonstrated by in vitro and in vivo models; however, the targets and mechanisms of IGF-I...Full Text Available

2010-05-01

111

Specific genetic modifications of domestic animals by gene targeting and animal cloning  

UK PubMed Central (United Kingdom)

The technology of gene targeting through homologous recombination has been extremely useful for elucidating gene functions in mice. The application of this technology was thought impossible in the large...Full Text Available

112

Selective imaging of adherent targeted ultrasound contrast agents  

UK PubMed Central (United Kingdom)

The goal of ultrasonic molecular imaging is the detection of targeted contrast agents bound to receptors on endothelial cells. We propose imaging methods that can distinguish adherent microbubbles...Full Text Available

2007-04-21

113

National Newborn Screening Status Reports  

Science.gov (United States)

... detected (and reported) as a by-product of MRM screening (MS/MS) targeted by Law or Rule ... detected (and reported) as a by-product of MRM screening (MS/MS) targeted by Law or Rule ...

114

Inhibitors of RecA Activity Discovered by High-Throughput Screening: Cell-Permeable Small Molecules Attenuate the SOS Response in Escherichia coli  

UK PubMed Central (United Kingdom)

The phenomenon of antibiotic resistance has created a need for the development of novel antibiotic classes with non-classical cellular targets. Unfortunately, target-based drug discovery against...Full Text Available

2009-10-01

115

How DNA coiling enhances target localization by proteins  

UK PubMed Central (United Kingdom)

Many genetic processes depend on proteins interacting with specific sequences on DNA. Despite the large excess of nonspecific DNA in the cell, proteins can locate their targets rapidly. After initial...Full Text Available

2008-10-14

116

Evolutionary conservation of a microbody targeting signal that targets proteins to peroxisomes, glyoxysomes, and glycosomes  

UK PubMed Central (United Kingdom)

Peroxisomes, glyoxysomes, glycosomes, and hydrogenosomes have each been classified as microbodies, i.e., subcellular organelles with an electron-dense matrix that is bound by a single membrane. We investigated...Full Text Available

1991-09-01

117

Efficient use of accessibility in microRNA target prediction  

UK PubMed Central (United Kingdom)

Considering accessibility of the 3′UTR is believed to increase the precision of microRNA target predictions. We show that, contrary to common belief, ranking by the hybridization energy or by...Full Text Available

2011-01-01

118

Coordination of PAD4 and HDAC2 in the regulation of p53 target gene expression  

UK PubMed Central (United Kingdom)

Histone Arg methylation and Lys acetylation have been found to cooperatively regulate the expression of p53 target genes. Peptidylarginine deiminase 4 (PAD4) is an enzyme that citrullinates...Full Text Available

2010-05-27

119

Concurrent schedule control of human visual target fixations1  

UK PubMed Central (United Kingdom)

Operant conditioning techniques were applied to the study of how target fixations are controlled by the probability of signal occurrence. In a standard vigilance setting, gaze at three illuminable...Full Text Available

1973-11-01

120

Biphasic targeting and cleavage furrow ingression directed by the tail of a myosin II  

UK PubMed Central (United Kingdom)

Cytokinesis in animal and fungal cells utilizes a contractile actomyosin ring (AMR). However, how myosin II is targeted to the division site and promotes AMR assembly, and how the AMR coordinates with...Full Text Available

2010-12-27

121

Assessment of nodal target definition and dosimetry using three different techniques: implications for re-defining the optimal pelvic field in endometrial cancer  

UK PubMed Central (United Kingdom)

Purposes1. To determine the optimal pelvic nodal clinical target volume for post-operative treatment of endometrial cancer. 2. To compare the DVH of different treatment planning...Full Text Available

122

Three-quasiparticle states in "1"7"7Ta  

International Nuclear Information System (INIS)

... transitions lutetium 175 target mev range 10-100 multipolarity neutrons parity

123

Terrorism Knowledge Base (TKB)  

Science.gov (United States)

... they assisted in the 2000 attack on the USS Cole? ... List the types of targets that ETA has attacked. ... was at least partially responsible for the attack. ...

2008-04-01

124

Surgical Counter-Terrorism: Targeting Individuals as an ...  

Science.gov (United States)

... Tanzania, and the attack on the USS COLE. ... vis another has no bearing on the legality of the attack. If the person attacked is a combatant, the use of ...

2003-02-03

125

Single-Walled Carbon Nanotubes Targeted to the Tumor ...  

Science.gov (United States)

... 1981. Retention of diphenyls, terphenyls, phenylalkanes and fluorene on graphitized thermal carbon black. Chromatographia 14:510-514. ...

2009-09-01

126

Review of Vaccinia Virus and Baculovirus Viability Versus ...  

Science.gov (United States)

... hazards. One study targeted the effects of common household disinfectants on virus inactivation (Butcher and Ulaeto, 2005). ...

2008-03-01

127

Production of polarized negative ion beams by collisional pumping  

Energy Technology Data Exchange (ETDEWEB)

The production of polarized negative ion beams by collisional pumping is described. Collisional pumping utilizes repeated charge changing collisions in a thick electron-spin-polarized gas or vapor target to form a polarized fast atom beam. The polarized fast atom beam is then partially converted into a polarized negative ion beam in a vapor target. Analysis is presented for a hydrogen beam passing through either a thick polarized H atom target or a thick polarized alkali target. Large polarizations and large currents may be possible.

1983-01-01

128

Production of polarized negative ion beams by ''collisional pumping''  

Energy Technology Data Exchange (ETDEWEB)

The production of polarized negative ion beams by ''collisional pumping'' is described. Collisional pumping utilizes repeated charge changing collisions in a thick electron-spin-polarized gas or vapor target to form a polarized fast atom beam. The polarized fast atom beam is then partially converted into a polarized negative ion beam in a vapor target. Analysis is presented for a hydrogen beam passing through either a thick polarized H atom target or a thick polarized alkali target. Large polarizations and large currents may be possible.

1984-03-01

129
131

Pairing effect in the nucleon transfer processes in quasi-elastic heavy ion scattering  

International Nuclear Information System (INIS)

... range krypton 86 reactions molybdenum 92 target probability quasi-elastic

1987-04-14

132

Market segmentation and targeting for real time pricing  

Energy Technology Data Exchange (ETDEWEB)

While there is growing interest in Real Time Pricing as a competitive tool, its adoption to date has been constrained by wariness on the part of many utilities and many of their customers. That wariness is not misplaced, for Real Time Pricing is not for everyone. In order for both utilities and their customers to benefit, the pricing system must be properly tailored for, and offered to, the appropriate audience. This paper discusses needs for identifying targets, implications of targeting of Real Time Pricing to various types of customers, and implications for design and marketing of such pricing systems. Examples from utility experiences are provided, and recommendations are offered for development of improved targeting of Real Time Pricing.

1996-03-01

133

Fragmentation of nuclei by particles and nuclei of intermediate and high energies  

Energy Technology Data Exchange (ETDEWEB)

The present state of investigations into the fragmentation of target nuclei by particles and nuclei of intermediate and high energies is reviewed.

1983-11-01

135

Electron-Induced Luminescence and X-Ray Spectrometer (ELXS) System for Life Detection  

Science.gov (United States)

The ELXS concept is a novel, portable, micro-instrument targeted for the detection of mineralogic

2002-01-01

136

Electromagnetic excitations in nuclei: From photon scattering to photo-dissociation  

International Nuclear Information System (INIS)

... 98 target molybdenum 99 niobium 91 photoneutrons photonuclear reactions

2006-03-20

137

Effect of improved target designs on the "2"3"8Pu production at the Fast Flux Test Reactor  

International Nuclear Information System (INIS)

This paper present the results of a series of calculations made to determine the "2"3"8Pu production potential of several advanced target assembly designs in the Fast Flux Test Facility (FFTF). These calculations show that by using advanced target designs the intimately mix the "2"3"7Np target material with an yttrium hydride moderator, the FFTF has the potential of producing up to 30 kg of high-quality "2"3"8Pu per year.

1991-11-10

138

Target space duality II: applications  

Energy Technology Data Exchange (ETDEWEB)

We apply the framework developed in Target space duality I: general theory. We show that both nonabelian duality and Poisson-Lie duality are examples of the general theory. We propose how the formalism leads to a systematic study of duality by studying few scenarios that lead to open questions in the theory of Lie algebras. We present evidence that there are probably new examples of irreducible target space duality.

2000-09-25

139

Gastrin releasing peptide (GRP) receptor targeted radiopharmaceuticals: A concise update  

Energy Technology Data Exchange (ETDEWEB)

The gastrin releasing peptide (GRP) receptor is becoming an increasingly attractive target for development of new radiolabeled peptides with diagnostic and therapeutic potential. The attractiveness of the GRP receptor as a target is based upon the functional expression of GRP receptors in several tumors of neuroendocrine origin including prostate, breast, and small cell lung cancer. This concise review outlines some of the efforts currently underway to develop new GRP receptor specific radiopharmaceuticals by employing a variety of radiometal chelation systems.

2003-11-01

140

Effluent reduction using pinch technology: Targets for reduction and capital costs for mass exchange networks  

Energy Technology Data Exchange (ETDEWEB)

This paper illustrates how the techniques developed by the authors for capital cost targeting of mass exchange networks can be applied to determination of capital investment targets for reduction in effluent for existing systems involving mass exchange. The results is an impact diagram which shows the relationship between effluent reduction and capital investment, indicating a region of limiting return on investment as well as the maximum possible reduction in effluent. (au)

1999-02-01

141

Development of a new secondary beam separator and a new gas-jet target at Kyushu University  

International Nuclear Information System (INIS)

In order to facilitate observations of low energy nuclear reactions, a new type recoil mass-separator together with a new gas-jet target system is being developed at the tandem accelerator facility in Kyushu University. The expected mass-resolving power of the separator is 220 for a solid angle of 10 msr and the practical thickness of the gas-jet target will exceed 0.1 atm#centre dot#cm for the light elements of H and He. (author).

1994-06-01

142

Detection device for high explosives  

Energy Technology Data Exchange (ETDEWEB)

A portable fiber optic detector that senses the presence of specific target chemicals by electrostatically attracting the target chemical to an aromatic compound coating on an optical fiber. Attaching the target chemical to the coated fiber reduces the fluorescence so that a photon sensing detector records the reduced light level and activates an appropriate alarm or indicator.

1992-01-01

143

A Liquid Parahydrogen Target for the Measurement of a Parity-violating Gamma Asymmetry in Polarized Neutron Capture on Protons  

Energy Technology Data Exchange (ETDEWEB)

A 16 l liquid parahydrogen target has been developed for a measurement of the parity-violating {gamma}-asymmetry in the capture of polarized cold neutrons on protons in the {rvec n} + p {yields} d + {gamma} reaction by the NPDGamma collaboration. The target system was carefully designed to meet the stringent requirements on systematic effects for the experiment and also to satisfy hydrogen safety requirements. The target was designed to preserve the neutron polarization during neutron scattering on liquid hydrogen (LH{sub 2}), optimize the statistical sensitivity to the {rvec n} + p {yields} d + {gamma} reaction, minimize backgrounds coming from neutron interaction with the beam windows of the target cryostat, minimize LH{sub 2} density fluctuations which can introduce extra noise in the gamma asymmetry signal, and control systematic effects. The target incorporates two mechanical ...

2010-05-01

144

48 CFR 952.226-73 - Energy Policy Act target group certification.  

Science.gov (United States)

...2010-10-01 2010-10-01 false Energy Policy Act target group certification...Acquisition Regulations System DEPARTMENT OF ENERGY CLAUSES AND FORMS SOLICITATION...Provisions and Clauses 952.226-73 Energy Policy Act target group...

2010-10-01

145

The effect of ion implantation of Ar on the aqueous corrosion resistance of Zr-4 alloy  

International Nuclear Information System (INIS)

The effect of ion implantation on the aqueous corrosion resistance of Zr-4 in deaerated 1N H_2SO_4 was studied with the potentiokinetic technique. The Zr-4 alloy was bombarded with 5x10"1"4-2x10"1"6 Ar/cm"2 of 190 keV. It was found that the passive current density of Zr-4 decreases with increasing implantation dose. Photoelectrochemical results show that the ion implantation of Ar in Zr-4 raises the flatband potential of its passive film. AES was employed to analyze the surface of the passive film of Zr-4. The decrease in passive current density may be attributed to a thickening oxide layer on Zr-4 and a decrease in concentration of oxygen vacancies in its passive film. ((orig.)).

146

The anisotropic growth in amorphous materials and the latent track formation induced by energetic ion bombardment  

Energy Technology Data Exchange (ETDEWEB)

The thermal spike model has been successfully applied to track formation by swift heavy ions in insulators. Arguments are given supporting the assumption that the thermal spike mechanism is also valid for the anisotropic growth. The glass transition temperature is used as the main thermal parameter of the amorphous solids. Experimental results on the track formation in {alpha}-quartz and in crystalline Ni{sub 3}B and also on the anisotropic growth in Pyrex and Synsil glasses, in amorphous Pd{sub 80}Si{sub 20}, Ni{sub 3}B and Fe{sub 85}B{sub 15} are discussed. Good agreement is found with the predictions of the thermal spike model. (orig.).

1996-02-01

147

Technique for generating atomic negative ion beams of the group IA elements  

Energy Technology Data Exchange (ETDEWEB)

A technique has been developed which enables the direct sputter generation of atomic negative ion beams of all members of the Group IA elements (Li, Na, K, Rb and Cs). The method is based on the use of sputter samples formed by pressing mixtures of the carbonates of the Group IA elements and 10% (atomic) Cu, Ag or other metal powders. The following intensities are typical of those observed from carbonate samples subjected to approx. = 3 keV cesium ion bombardment: Li/sup -/: greater than or equal to 0.5 ..mu..A; Na/sup -/: greater than or equal to 0.5 ..mu..A; K/sup -/: greater than or equal to 0.5 ..mu..A; Rb/sup -/: greater than or equal to 0.5 ..mu..A; Cs/sup -/: greater than or equal to 0.2 ..mu..A.

1989-03-15

148

Simultaneous Formation of Surface Ripples and Metallic Nanodots Induced by Phase Decomposition and Focused Ion Beam Patterning  

Energy Technology Data Exchange (ETDEWEB)

We report the simultaneous formation of self-assembled surface ripples in Cd{sub 2}Nb{sub 2}O{sub 7} pyrochlore caused by focused ion beam (FIB) patterning and uniformly distributed metallic nanodots induced by phase decomposition under ion bombardment. The characteristic wavelength of the surface ripples is controllable from the nm to the sub-{micro}m scale. High-density Cd metallic nanoparticles, {approx} 5 nm, formed and the distribution of nanoparticles is consistent with the morphological characteristics of the ripple pattern. This approach provides a means of fabricating surface nanostructure with various patterns and a controllable particle size and distribution by combining ion beam-induced phase decomposition with high-precision FIB patterning.

2006-02-01

149

Simulation study on retention and reflection from tungsten carbide under high fluence of helium ions  

Energy Technology Data Exchange (ETDEWEB)

We have studied, by a Monte Carlo simulation code ACAT-DIFFUSE, the fluence-dependence of the amount of retained helium atoms in tungsten carbide at room temperature under helium ion bombardment. The retention behavior may be understood qualitatively in terms of irradiation-dependent diffusion coefficient assumed and range. The emission processes from tungsten carbide under helium ion irradiation derived were compared with each other. We have discussed the retention curves for incident energy of 5 keV at incident angles of 0deg and 80deg and of 500 eV at 0deg. The energy spectra of helium atoms reflected from tungsten carbide for incident energy of 500 eV at 0deg and 80deg were compared with those from graphite and tungsten. (author)

2000-08-01

150

On plasma nitriding of steels  

Energy Technology Data Exchange (ETDEWEB)

With the aim of optimizing the nitriding process, experimental studies of the plasma nitriding of four selected steels were carried out, using a d.c. glow discharge. The process parameters were varied systematically. By means of transmission and scanning electron microscopy and X-ray diffraction, the microstructures, including the thicknesses of the compound zones and the diffusion zones of the nitrided steels, were obtained. Using cross-sectional samples and a micro-Vickers indenter, hardness depth profiles were also obtained. From the time and temperature dependences of the hardness profiles, effective diffusion constants and corresponding activation enthalpies were obtained. Furthermore, in an attempt to shed some light on the atomistic nitriding mechanisms, the glow discharges were studied by measuring energy spectra of the energetic ions hitting the cathode (the steel test specimens). It was shown that an increase of the mean energy of the ions bombarding the ...

2000-02-01

151

Modeling of sputtering and redeposition in focused-ion-beam trench milling  

Energy Technology Data Exchange (ETDEWEB)

Modeling is performed for focused-ion-beam (FIB) sputtering and redeposition on trench sidewalls in a steady state approximation. Calculations are carried out to demonstrate the sputtered surface profile under known parameters such as sputtering yield as a function of ion incident angle, the FIB current density profile, and the FIB scan speed. It is found that a steplike slope with a gradient angle of {theta}{sub 0} is formed at the FIB bombarding position. Furthermore, the redeposition flux on the sidewalls is calculated as a function of {theta}{sub 0} for the FIB trench milling assuming the cosine law for the angular distribution of the sputtered atom. The redeposition will be more accurately predictable and controllable when more information about these assumptions is obtained.

1991-11-01

152

Modeling of sputtering and redeposition in focused-ion-beam trench milling  

International Nuclear Information System (INIS)

Modeling is performed for focused-ion-beam (FIB) sputtering and redeposition on trench sidewalls in a steady state approximation. Calculations are carried out to demonstrate the sputtered surface profile under known parameters such as sputtering yield as a function of ion incident angle, the FIB current density profile, and the FIB scan speed. It is found that a steplike slope with a gradient angle of #theta#_0 is formed at the FIB bombarding position. Furthermore, the redeposition flux on the sidewalls is calculated as a function of #theta#_0 for the FIB trench milling assuming the cosine law for the angular distribution of the sputtered atom. The redeposition will be more accurately predictable and controllable when more information about these assumptions is obtained.

153

Measurement of beta-decay half-lives of short-lived nuclei with Spectrum Multi-Scaler (SMS)  

Energy Technology Data Exchange (ETDEWEB)

The half-lives of short-lived nuclei produced by 14 MeV or thermal neutron bombardments were measured with a Ge detector, a Spectrum Multi-Scaler (Laboratory Equipment Corporation SMS-48) and a High-Rate Spectroscopy Amplifier (EG and G ORTEC Model 973) in the multi-scaling mode. The corrections for pile-up and dead-time losses were performed by applying source and pulser methods. The half-lives of {sup 91m}Mo, {sup 97m}Nb, {sup 138}Cs, {sup 139}Ba, {sup 174}Tm and {sup 203m}Pb were determined with accuracy of 0.22-0.6% and the accuracy has been much improved. (author)

1996-03-01

154

Ion beam induced damage and element loss during a microanalysis of biological tissue  

Energy Technology Data Exchange (ETDEWEB)

Specimen damage and element loss induced by 3 MeV proton and 2 MeV alpha particle bombardment of thin sections of freeze-dried kidney tissue and embedding medium have been studied. Yields of ions scattered from H and C, and characteristic X-rays were measured versus accumulated charge, for curent densities in the range from 8x10{sup -15} to 1.1x10{sup -11} A/{mu}m{sup 2}. Structural damage, dissolouration and loss of S, Cl, C and H have been observed. Implications of this study for ion beam microanalysis of biological tissues are discussed with particular reference to the results for H loss. (orig.).

1991-03-01

155

Empirical relationship between track diameter and etching time for fission fragments incident on a glass SSNTD at various angles of incidence  

Energy Technology Data Exchange (ETDEWEB)

Geometrical shapes and diameter of nuclear tracks changes continuously during the process of etching for various incident angles. Besides, there is also a marked difference amongst their profiles, as evidenced by the SEM analysis, when the incoming particles fall on the detector at different angles of incidence. This work outlines this aspect of fission fragment tracks in a glass detector and has set out a few empirical relationships between the mean track diameter, d-bar and the etching time, t, within experimental limits. This study, therefore, sheds some light in the follow up the origins and characteristics of heavy ions in some terrestrial and extra-terrestrial materials and also in studying the collimation accuracy of heavy ion bombardments. The implications of the results in discerning the measurements of incident angles of various types of ions are described in detail in the paper.

1983-09-01

156

ESR dating of fault rocks  

Energy Technology Data Exchange (ETDEWEB)

Past movement on faults can be dated by measurement of the intensity of ESR signals in quartz. These signals are reset by local lattice deformation and local frictional heating on grain contacts at the time of fault movement. The ESR signals then trow back as a result of bombardment by ionizing radiation from surrounding rocks. The age is obtained from the ratio of the equivalent dose, needed to produce the observed signal, to the dose rate. Fine grains are more completely reset during faulting, and a plot of age vs grain size shows a plateau for grains below critical size : these grains are presumed to have been completely zeroed by the last fault activity. We carried out ESR dating of fault rocks collected from the Yangsan fault system. ESR dates from the this fault system range from 870 to 240 ka. Results of this research suggest that long-term cyclic fault activity continued into the pleistocene.

2002-03-15

157

Construction and development of a UV free electron laser under the cooperation of Nihon U, KEK, PNC, ETL and Tohoku U  

Energy Technology Data Exchange (ETDEWEB)

The construction and the development of a UV free electron laser have been started under the cooperation of Nihon U, KEK, PNC, ETL and Tohaku U. The project requires a 100MeV S-band electron linear accelerator to expand the oscillation of FEL using fundamental mode to the UV region. The injection system consists of a thermionic RF-gun with a LaB cathode and an {alpha} magnet for magnetic bunching. We are studying to reduce the back-bombardment electrons to realize the macropulse length of 20{mu}sec. Electron beams, up to the energy of 100MeV, are injected into the optical oscillators. Changing the accelerating energy and/or undulator parameters, this system will cover the range from infrared to ultraviolet for the applications in various fields.

1995-12-31

158

Ar/sup +/ ion beam induced silicide formation mechanism at the Pf-Si interface  

Energy Technology Data Exchange (ETDEWEB)

Evaporated palladium films of 45 nm thickness on Si(111) were irradiated using 78 keV Ar/sup +/ ions with doses in the range of 1 x 10/sup 15/ to 1.5 x 10/sup 16/ cm/sup -2/ for the purpose of studying silicide formation. Rutherford backscattering analysis shows that intermixing has occurred across the Pd-Si interface at room temperature. The mixing behaviour increases with increasing dose of the bombarding ions, which agrees well with a theoretical model of isotropic cascade mixing for palladium, and radiation-enhanced diffusion associated with an interstitial mechanism for silicon.

1989-01-01

159

Alpha-induced reactions in iridium  

Energy Technology Data Exchange (ETDEWEB)

The excitation function of ({alpha},{ital xn}) reactions on {sup 191}Ir (abundance 37.3%) and on {sup 193}Ir (abundance 62.7%) has been measured for the 17--55 MeV alpha-particle bombarding energy range. The stacked foil activation technique and {gamma}-ray spectroscopy were used to determine the cross sections. The experimental data were compared with calculated values obtained by means of a geometry-dependent hybrid model. The initial exciton number {ital n}{sub 0}=4 with {ital n}=2, {ital p}=2, and {ital h}=0 gives the best agreements with the presently measured results. To calculate the excitation function theoretically a computer code was used. This set of excitation functions provides a data basis for probing the validity of combined equilibrium and preequilibrium reaction models in a considerable energy range.

1992-05-01

160

Selection of IFE target materials from a safety and environmental perspective  

International Nuclear Information System (INIS)

Target materials for inertial fusion energy (IFE) power plant designs might be selected for a wide variety of reasons including wall absorption of driver energy, material opacity, cost and ease of fabrication. While each of these issues are of great importance, target materials should also be selected based upon their safety and environmental (S and E) characteristics. The present work focuses on the recycling, waste management and accident dose characteristics of potential target materials. If target materials are recycled so that the quantity is small, isotopic separation may be economically viable. Therefore, calculations have been completed for all stable isotopes for all elements from lithium to polonium. The results of these calculations are used to identify specific isotopes and elements that are most likely to be offensive as well as those most likely to be acceptable in terms of their S and E ...

2001-05-21

161

Mode of action of membrane-disruptive lytic compounds from the marine dinoflagellate Alexandrium tamarense  

British Library Electronic Table of Contents (United Kingdom)

Certain allelochemicals of the marine dinoflagellate Alexandrium tamarense cause lysis of a broad spectrum of target protist cells but the lytic mechanism is poorly defined. We first hypothesized that membrane sterols serve as molecular targets of these lytic compounds, and that differences in sterol composition among donor and target cells may cause insensitivity of Alexandrium and sensitivity of targets to lytic compounds. We investigated Ca^2^+ influx after application of lytic fractions to a model cell line PC12 derived from a pheochromocytoma of the rat adrenal medulla to establish how the lytic compounds affect ion flux associated with lysis of target membranes. The lytic compounds increased permeability of the cell membrane for Ca^2^+ ions even during blockade of Ca^2^+ channels wit...

2011-01-01

162

An identification method of positron production in laser beam interaction with targets  

Energy Technology Data Exchange (ETDEWEB)

A simple electromagnetic transport system was constructed to identify very rare positrons produced in a powerful laser beam interaction with a target. Testing experiments were carried out with CO[sub 2]-laser (10[sup 12] W/cm[sup 2]) beam pulses ([tau] = 50 ns, f = 0.01 Hz) focused on the copper target, as well as with a 96 MeV alpha-particle beam irradiated carbon target. The results showed that the developed system could be effectively used for positron identification and evaluation of their energy by means of a time-of-flight method. The computerized system to deal with this problem, together with others related to the power laser beam interaction with targets, has been constructed. (orig.).

1992-10-01

163

Activation analysis of target debris in the national ignition facility  

International Nuclear Information System (INIS)

The modeling methods used to compute the neutron-induced activation of target and near-target materials in the NIF facility are presented. A detailed space and energy description of the neutron environment in the different materials is provided. A new capability has been developed to treat in a general way the activation of debris produced in an operational regime of yield and no-yield experiments. First calculations are addressed to analyze the activity of the debris into the target chamber. The contribution of the different components to activity, interior dose rates, and waste disposal rating (WDR) is determined. The importance of the activation coming from primary irradiation in the target, and from secondary irradiation in debris deposited onto the first wall is assessed. Finally, waste hazards of the activated debris when removed out of the chamber and stored are analyzed. (authors)

1999-09-12

164

[Improvement of the recognition probability about camouflage target based on BP neural network].  

Science.gov (United States)

Using static Michelson interferometer to get the spectrum information of measurement targets for spectrum identification, under the condition that the interference length is constant, the system can be optimized by BP neural network algorithm for the mixed spectral separation process. Thereby it can realize improving the recognition probability of camouflage target. Collecting the spectrum information in field of view (FOV) by the interferometer and linear array CCD detector, composing the set of mixed spectrum data, with known absorption spectrum of the material as a hidden layer of rules, it used BP neural network to separate the mixed spectrum data. Experiment with different distances, different combinations of mixed background spectrum as the initial data, using steel target (size: 1.5 m x 1.5 m) made of four kinds, the recognition probability of non-camouflage target is about 90% by BP neural ...

2010-12-01

165

Traffic and transport in the Dutch National Environmental Outlook 4; Verkeer en vervoer in de Nationale Milieuverkenning 4  

Energy Technology Data Exchange (ETDEWEB)

In the Fourth Dutch National Environmental Outlook (NMP, abbreviated in Dutch) of the National Institute of Public Health and the Environment (VROM), published in July 1997, possible future developments in the traffic and transport sector in the Netherlands are described for the period 1995-2020 and also evaluates present Dutch policies. NMP-4 also offers possible solutions for expected environmental problems. This report serves as a background document for the traffic and transport sector. With a view to present Dutch policies, the main conclusions drawn from the Outlook are that: (1) the policy targets for car and lorry use for 2010 will not be met, (2) the target for CO2 emissions from road transport for 2010 will not be met, (3) the NOx emission target for 2010 will be met for cars, but not for trucks, (4) the VOC emission target for 2010 will be met for cars, but not for trucks, and (5) the noise ...

1998-03-01

166

The influence of process gas characteristics on the properties of plasma nitrided steel  

Energy Technology Data Exchange (ETDEWEB)

This study attempts to elucidate some of the effects of adding argon, neon and hydrogen to low pressure thermionically supported discharges used for plasma nitriding AISI M2 steel substrates. Four runs were performed at the same substrate temperature (550 C) and bias voltage (500 V), using the following gas mixtures: 8% N{sub 2} in Ar, 8% N{sub 2} in Ne, N{sub 2}+H{sub 2} in equal proportions, and N{sub 2} only. By careful control of the discharge parameters, most of the bombardment energy was transported to the substrates by 500 eV ions in all cases; these were mainly Ar{sup +} ions in the N{sub 2}+Ar run and N{sub 2}{sup +} ions in the other runs, notably by the action of Penning ionization in the N{sub 2}+Ne run. We found that the surface hardness was not significantly influenced by the type of ion delivering the bombardment energy, although we suggest that ions would need sufficient mass to cause (for example) sputtering, if the substrate ...

1995-12-01

167

Swelling behavior of a simple ferritic alloy  

International Nuclear Information System (INIS)

The swelling behavior which results from simulated fusion environment irradiation of Fe-10% Cr has been characterized with transmission electron microscopy. Specimens were bombarded at 850 K with: a ''triple-beam'' of He"+, D_2"+, and 4 MeV Fe"+"+ ions to 0.3, 1, 3, 10, 30, and 100 dpa (displacement per atom); a ''dual-beam'' of He"+ and 4 MeV Fe"+"+ ions to 30 and 100 dpa; and a ''single-beam'' of 4 MeV Fe"+"+ ions to 30 dpa. The helium and hydrogen injection rates were approx. =10 appm He/dpa and approx. =40 appm D/dpa. Cavities were observed for damage levels of 3 dpa and greater. The swelling was <0.1% for damage levels <30 dpa, but at 100 dpa, there was an increase in the swelling to 2.5% for the ''triple-beam'' irradiation and 1.2% for the ''dual-beam'' irradiation. The swelling rates between 30 and 100 dpa correlate well with calculated values assuming a steady-state swelling-rate regime has been reached. Calculations show the rapid cavity growth ...

168

Properties of cubic boron nitride films with buffer layer control for stress relaxation using ion-beam-assisted deposition  

Energy Technology Data Exchange (ETDEWEB)

Significant ion irradiation during film growth is required for the formation of cubic boron nitride (cBN) films. Meanwhile, a huge level of intrinsic stress possibly induced by the ion bombardment has been frequently reported to result in cracking and/or lack of adhesion of deposited cBN films. The present work has been performed to investigate the interfacial and/or the buffer layer structures with better matching to the cBN film by relaxation of the film stress using ion-beam-assisted deposition (IBAD). Boron nitride films have been synthesized on Si(100) wafer and tungsten carbide (WC) substrates by depositing boron vapor under simultaneous bombardment with nitrogen ions and nitrogen-argon mixture ions in the energy range of 0.5-10 keV. Cubic BN films with enhanced tribological properties have been explored by inserting a BN layer with various B/N compositions as a controlled buffer at the interface. Significant relaxation of the film stress ...

1999-09-01

169

Is uniform target dose possible in IMRT plans in the head and neck?  

International Nuclear Information System (INIS)

Purpose: Various published reports involving intensity-modulated radiotherapy (IMRT) plans developed using automated optimization (inverse planning) have demonstrated highly conformal plans. These reported conformal IMRT plans involve significant target dose inhomogeneity, including both overdosage and underdosage within the target volume. In this study, we demonstrate the development of optimized beamlet IMRT plans that satisfy rigorous dose homogeneity requirements for all target volumes (e.g., #+-#5%), while also sparing the parotids and other normal structures. Methods and Materials: The treatment plans of 15 patients with oropharyngeal cancer who were previously treated with forward-planned multisegmental IMRT were planned again using an automated optimization system developed in-house. The optimization system allows for variable sized beamlets computed using a three-dimensional convolution/superposition dose ...

2002-04-01

170

Radioisotope production in the I.Ph.P.E. cyclotron for medical application  

International Nuclear Information System (INIS)

The production methods for seven radioisotopes, Ga-67, Sr-85, Pd-103, In-111, Tu-167, Hg-197 and Pb-203, by using a classical 1.5m cyclotron in the Institute of Physics and Power Engineering, Obninsk, USSR, are described. At present, more than 50 cyclotrons in different countries are used for the production of radioisotopes applied to medicine. Radioisotopes are produced with the cyclotron in the I.Ph.P.E. in the form of irradiated targets, which are delivered to Moscow radiopharmaceutical factory, where radiopharmaceuticals are produced on the base of these targets. The cyclotron is operated in two regimes providing the acceleration of protons, deuterons and alpha -particles. Two types of target assemblies are used for irradiation, the one is intended for the internal beam, and the other is for the external beam. The reactions used for the production of seven radioisotopes described above, the types of ...

171

Radioisotope production in the I. Ph. P. E. cyclotron for medical application  

Energy Technology Data Exchange (ETDEWEB)

The production methods for seven radioisotopes, Ga-67, Sr-85, Pd-103, In-111, Tm-167, Hg-197 and Pb-203, by using a classical 1.5m cyclotron in the Institute of Physics and Power Engineering, Obninsk, USSR, are described. At present, more than 50 cyclotrons in different countries are used for the production of radioisotopes applied to medicine. Radioisotopes are produced with the cyclotron in the I.Ph.P.E. in the form of irradiated targets, which are delivered to Moscow radiopharmaceutical factory, where radiopharmaceuticals are produced on the base of these targets. The cyclotron is operated in two regimes providing the acceleration of protons, deuterons and alpha -particles. Two types of target assemblies are used for irradiation, the one is intended for the internal beam, and the other is for the external beam. The reactions used for the production of seven radioisotopes described above, the types of ...

1982-01-01

172

Distortion-invariant color pattern recognition using multiple phase-shifted-reference-based joint transform correlation incorporating synthetic discriminant function  

Science.gov (United States)

This paper proposes a new pattern recognition system employing optical joint transform correlation (JTC) technique which offers a great number of advantages over similar digital techniques, including very fast operation, simple architecture and capability of updating the reference image in real time. The proposed JTC technique incorporates a synthetic discriminant function (SDF) of the target image estimated from different training images to make the pattern recognition performance invariant to noise and distortion. It then involves four different phase-shifted versions of the same target SDF reference image, which are individually joint transform correlated with the given input scene. When the correlation signals are combined, it produces a single cross-correlation peak corresponding to each potential target present in the given input scene. The proposed technique also includes a fringe-adjusted filter to generate a ...

2011-04-01

173

Uses of laser optical pumping to produce polarized ion beams  

Energy Technology Data Exchange (ETDEWEB)

Laser optical pumping can be used to produce polarized alkali atom beams or polarized alkali vapor targets. Polarized alkali atom beams can be converted into polarized alkali ion beams, and polarized alkali vapor targets can be used to produce polarized H/sup -/ or /sup 3/He/sup -/ ion beams. In this paper the authors discuss how the polarized alkali atom beams and polarized alkali vapor targets are used to produce polarized ion beams with emphasis on the production of polarized negative ion beams.

1983-04-01

174

The HARP experiment first physics results  

CERN Document Server

The HARP experiment at CERN is performing extensive measurements of hadron production cross sections and secondary particle yields, in the momentum range 1.5-15 GeV/c, over the full solid angle and using a large set of cryogenic and solid targets. First measurements of hadron production cross-sections in the forward region are reported using an aluminium target 5% of an interaction length thick and a proton beam of 12.9 GeV/c. A preliminary analysis in the large angle region of elastic scattering events produced with the cryogenic hydrogen target at 3 GeV/c beam momentum is also presented.

2005-01-01

175

Separation of carrier-free "1"7"6","1"7"7W and "1"7"6","1"7"7Ta produced in "1"6O irradiated holmium target  

International Nuclear Information System (INIS)

Carrier-free radionuclides of tungsten and tantalum, "1"7"6","1"7"7W and "1"7"6","1"7"7Ta have been produced by heavy ion activation of holmium target with 97 MeV "1"6O"5"+ beam. Radiochemical separation scheme has been developed to isolate tungsten and tantalum radionuclides from the holmium target matrix. (author)

2001-11-01

176

Separation of carrier free "1"7"6","1"7"7W and "1"7"6","1"7"7Ta radionuclides produced in "1"6O activated holmium metal target  

International Nuclear Information System (INIS)

Carrier-free radioisotopes of tungsten, "1"7"6","1"7"7W, and their corresponding daughter radionuclides "1"7"6","1"7"7Ta, have been produced in holmium target by heavy ion activation with "1"6O"5"+ beam. An attempt has been made to separate these carrier-free radionuclides from bulk holmium target through LLX using cation exchanger HDEHP. (author)

2001-02-07

177

Recovery of radioactive thallium isotopes from lead and bismuth targets irradiated by 1-GeV protons  

Energy Technology Data Exchange (ETDEWEB)

A simple highly efficient procedure has been developed for recovery of thallium radioisotopes from lead and bismuth targets irradiated by 1-GeV protons. The procedure is based on the use of extraction chromatography. The cross-sections have been determined for formation of {sup 200}Pb, {sup 201}Pb, {sup 202m}Pb, and {sup 203}Pb radioisotopes in targets from lead with natural isotopic composition, irradiated by 1-GeV protons.

1995-03-01

178

Recovery of radioactive thallium isotopes from lead and bismuth targets irradiated by 1-GeV protons  

International Nuclear Information System (INIS)

A simple highly efficient procedure has been developed for recovery of thallium radioisotopes from lead and bismuth targets irradiated by 1-GeV protons. The procedure is based on the use of extraction chromatography. The cross-sections have been determined for formation of "2"0"0Pb, "2"0"1Pb, "2"0"2"mPb, and "2"0"3Pb radioisotopes in targets from lead with natural isotopic composition, irradiated by 1-GeV protons.

179

Preliminary Study of Plasma Stream Interaction with Tungsten Target within RPI-IBIS Facility  

International Nuclear Information System (INIS)

The paper presents results of experimental research on the interaction of a pulsed plasma-ion stream with a tungsten (W) target. The pulsed hydrogen plasma was produced within the RPI-IBIS (Multi-Rod Plasma Injector) facility at IPJ in Swierk. Measurements were carried out by means of optical spectroscopy and corpuscular diagnostic techniques. For experiments with the W-target the operational conditions (so-called PID mode) were chosen when a clean hydrogen plasma stream was generated. Attention was paid to the identification of WI and WII spectral lines.

2006-01-01

180

Modified-VSIMM algorithm with an application to the naval fire control technology  

British Library Electronic Table of Contents (United Kingdom)

A modified variable structure interacting multiple model (M-VSIMM) estimator for complex hybrid maneuver target tracking is presented. The M-VSIMM could potentially be applied to fire control systems (FCS) used on warships. Target model groups were designed using 3D dimensional dynamic target models. Optimal model group selection logic was proposed, contrary to the activation and termination logic in the original VSIMM. The system will respond faster with optimal model group selection logic. After performing simulations, the tracking performances of the Kalman, ?-?(-?), VDIE, IMM and M-VSIMM filters were compared under various maneuvering conditions.

2011-01-01

181

Experiments to investigate the effects of radiative cooling on plasma jet collimation  

CERN Document Server

Preliminary experiments have been performed to investigate the effects of radiative cooling on plasma jets. Thin (3 um - 5 um) conical shells were irradiated with an intense laser, driving jets with velocities > 100 km/s. Through use of different target materials - aluminium, copper and gold - the degree of radiative losses was altered, and their importance for jet collimation investigated. A number of temporally resoved optical diagnostics was used, providing information about the jet evolution. Gold jets were seen to be narrower than those from copper targets, while aluminium targets produced the least collimated flows.

2010-01-01

182

Convoy electron production in polycrystalline and monocrystalline targets  

Energy Technology Data Exchange (ETDEWEB)

The velocity distribution of electrons ejected close to the forward direction by 0.8-2 MeV/A ions traversing various solid targets, including a Au monocrystal, is measured in coincidence with emerging charge-selected ions. The velocity spectrum is observed to be independent of outgoing projectile velocity and charge state for polycrystalline targets. Measurements on the Au crystal under channeling conditions show dependences on final charge state, and are tentatively explained by assuming that the main contribution to the production yield comes from the non-channeled fraction of the ions. A simple model for the creation of the forward-ejected electrons is proposed, which accounts for most of the experimental findings.

1980-01-01

183

Computer-assisted rotation and multiple stationary irradiation technique  

International Nuclear Information System (INIS)

A computer-assisted rotation and stationary conformation radiotherapy system with overrunning multileaf collimators has been developed. This system can produce any shape of target volume, including a number of target areas outside the axis of the rotation, regardless of the location of the axis at 360"0 rotation irradiation. In addition, by changing the dose rate and deleting a partial region within a field, multiple stationary irradiation can produce more homogeneous target volumes - thus avoiding excessive irradiation to critical organs - than the rotation technique. (orig.).

184

Centroid and Envelope Dynamics of High-intensity Charged Particle Beams in an External Focusing Lattice and Oscillating Wobbler  

Energy Technology Data Exchange (ETDEWEB)

The centroid and envelope dynamics of a high-intensity charged particle beam are investigated as a beam smoothing technique to achieve uniform illumination over a suitably chosen region of the target for applications to ion-beam-driven high energy density physics and heavy ion fusion. The motion of the beam centroid projected onto the target follows a smooth pattern to achieve the desired illumination, for improved stability properties during the beam-target interaction. The centroid dynamics is controlled by an oscillating "wobbler", a set of electrically-biased plates driven by RF voltage. __________________________________________________

2010-04-28

185

Yields of Residual Nuclei from Proton-Irradiated Materials  

International Science & Technology Center (ISTC)

Experimental and Theoretical Study of the Residual Nuclide Production in 40-2600 MeV Proton-Irradiated Thin Targets of ADS Basic Materials

186

Tuberculous Granulomas Are Hypoxic in Guinea Pigs, Rabbits, and Nonhuman Primates?  

UK PubMed Central (United Kingdom)

Understanding the physical characteristics of the local microenvironment in which Mycobacterium tuberculosis resides is an important goal that may allow the targeting of metabolic processes...Full Text Available

2008-06-01

188

The importance of an accurate target wave function in variational calculations for (e^{+}-H_{2}) scattering  

CERN Document Server

Using the complex Kohn method, we have calculated variational values of phase shifts and the annihilation parameter, Z_{eff}, for the elastic scattering of positrons by molecular hydrogen. Our results are sensitive to small changes in the accuracy of the wave function representing the target hydrogen molecule. We have developed a systematic approach to demonstrate that, at low positron energies, there are particular forms of the Kohn trial wave function for which the results of variational calculations are not reliable, even when the target wave function accounts for as much as 96.8% of the correlation energy of H_{2}. We find that reliable results can be recovered if our calculations are extended to admit more sophisticated target wave functions accounting for 99.7% of the correlation energy. Remaining discrepancies between theory and experiment are briefly discussed.

2008-01-01

189

The Growth Cone Cytoskeleton in Axon Outgrowth and Guidance  

UK PubMed Central (United Kingdom)

Axon outgrowth and guidance to the proper target requires the coordination of filamentous (F)-actin and microtubules (MTs), the dynamic cytoskeletal polymers that promote shape change and locomotion....Full Text Available

190

The Development of New Methods for Solving the Target ...  

Science.gov (United States)

... and 7 survey papers. On the inverse Stefan problem he wrote 3 research papers and 1 survey paper. The papers on inverse ...

1984-07-18

191

Target space duality I: general theory  

Energy Technology Data Exchange (ETDEWEB)

We develop a systematic framework for studying target space duality at the classical level. We show that target space duality between manifolds M and M-tilde arises because of the existence of a very special symplectic manifold. This manifold locally looks like MxM-tilde and admits a double fibration. We analyze the local geometric requirements necessary for target space duality and prove that both manifolds must admit flat orthogonal connections. We show how abelian duality, nonabelian duality and Poisson-Lie duality are all special cases of a more general framework. As an example we exhibit new (nonlinear) dualities in the case M=M-tilde=R{sup n}.

2000-09-25

192

Studies of relativistic heavy ion collisions at the AGS (Experiment 814)  

Energy Technology Data Exchange (ETDEWEB)

This report discusses the experimental setup of experiment 814 at Brookhaven AGS. This experiment involves the collision of silicon ions with target nuclei. The detector systems are discussed primarily. (LSP)

1990-01-01

193

Smoking and reproduction: The oviduct as a target of cigarette smoke  

UK PubMed Central (United Kingdom)

The oviduct is an exquisitely designed organ that functions in picking-up ovulated oocytes, transporting gametes in opposite directions to the site of fertilization, providing a suitable environment...Full Text Available

194

Simultaneous recognition and segmentation of cells: application in C.elegans  

UK PubMed Central (United Kingdom)

Motivation: Automatic recognition of cell identities is critical for quantitative measurement, targeting and manipulation of cells of model animals at single-cell resolution. It has been...Full Text Available

2011-10-15

195

Principles of antibody therapy.  

UK PubMed Central (United Kingdom)

The success of monoclonal antibodies in clinical practice is dependent on good design. Finding a suitable target is the most important part as other properties of the antibody can be altered by genetic...Full Text Available

1992-12-05

196

Novel Cytotoxic Vectors Based on Adeno-Associated Virus  

Wastenet

positive primary PymT breast cancer cells in primary co-cultured tumor tissue, suggesting target specificity of

197

Measured Temperatures of Solid Rocket Motors Dump Stored ...  

Science.gov (United States)

... TARGET SENSOR-MK 80 SERIES BOMBS ... 5-inch-, and 2.75-inch- diameter rocket motors that ... balance when compared to incoming solar radiation ...

1989-07-01

198

Knowledge-Based Identification of the ERK2/STAT3 Signal Pathway as a Therapeutic Target for Type 2 Diabetes and Drug Discovery  

British Library Electronic Table of Contents (United Kingdom)

Many existing agents for diabetes therapy are unable to restore or maintain normal glucose homeostasis or prevent the eventual emergence of hyperglycemia-related complication. Therefore, agents based on novel mechanisms are sought to complement and extend the current therapeutic approaches. Based on the initial paper research, we focused on active STAT3 as an attractive pharmacological target for type 2 diabetes. The subsequent text mining with a unique query to identify suppressors but not activators of STAT3 revealed the ERK2/STAT3 pathway as a novel diabetes target. The description of ERK2 inhibitors as diabetes target had not been found in our text mining research at present. The mechanism-based peptide inhibitor for ERK2 was identified using the knowledge of the KIM sequence, which ha...

2011-01-01

199

Johnson News - NASA  

Science.gov (United States)

Nov 21, 2003... for the European Space Agency's Automated Transport Vehicle, a new, uncrewed station cargo vehicle targeted for launch late next year. ...

200

Ion channels, transporters, and pumps as targets for heart failure  

UK PubMed Central (United Kingdom)

Congestive heart failure (CHF) is a leading cause of morbidity and mortality. CHF is marked by atrial and ventricular enlargement and reduced cardiac contractility, as well as an association...Full Text Available

2009-10-01

201

Imaging immune response in vivo  

UK PubMed Central (United Kingdom)

PurposeClinical trials have commenced to evaluate the feasibility of targeting malignant gliomas with genetically engineered cytolytic T-cells (CTLs) delivered directly...Full Text Available

2008-06-15

202

Heat shock proteins as emerging therapeutic targets  

UK PubMed Central (United Kingdom)

Chaperones (stress proteins) are essential proteins to help the formation and maintenance of the proper conformation of other proteins and to promote cell survival after a large variety of environmental...Full Text Available

2005-11-01

203

Genomics of human longevity  

UK PubMed Central (United Kingdom)

In animal models, single-gene mutations in genes involved in insulin/IGF and target of rapamycin signalling pathways extend lifespan to a considerable extent. The genetic, genomic and epigenetic influences...Full Text Available

2011-01-12

204

Gene therapy for ocular diseases  

UK PubMed Central (United Kingdom)

The eye is an easily accessible, highly compartmentalised and immune-privileged organ that offers unique advantages as a gene therapy target. Significant advancements have been made in understanding...Full Text Available

2011-05-01

205

GAVA: Spectral Simulation for In Vivo MRS Applications  

UK PubMed Central (United Kingdom)

An application that provides a flexible and easy to use interface to the GAMMA spectral simulation package is described that is targeted at investigations using in vivo MR spectroscopic methods....Full Text Available

2007-04-01

206

Evaluation of phenylpiperazines as targeting agents for neuroblastoma.  

UK PubMed Central (United Kingdom)

The potential of radiolabelled phenylpiperazines as agents for the detection and therapy of tumours of neural crest origin was evaluated by in vitro pharmacological studies with human neuroblastoma...Full Text Available

1996-09-01

207

Effects of voicing in the recognition of concurrent syllables (L)a)  

UK PubMed Central (United Kingdom)

This letter reports a study designed to measure the benefits of voicing in the recognition of concurrent syllables. The target and distracter syllables were either voiced or whispered, producing...Full Text Available

2009-12-01

208

Dynamic clamp with StdpC software  

UK PubMed Central (United Kingdom)

Dynamic clamp is a powerful method that allows the introduction of artificial electrical components into target cells to simulate ionic conductances and synaptic inputs. This method is based...Full Text Available

2011-03-01

209

Dynamic Weapon-Target Assignment Problems with ...  

Science.gov (United States)

... defense's weapons are Space-based kinetic-kill vehicles ... I ti I obtained by dividing the weapons as ... of the optimal weapon-arge assigntments and ...

1988-06-01

210

Cooperative Charging Effects of Fibers From Electrospinning ...  

Science.gov (United States)

... In the Proceedings of INTC 2003, we studied charging effects on target coverage during electrospinning (16). ... of Fibers from Electrospinning of ...

2005-01-05

211

Comparative genomics of insect juvenile hormone biosynthesis?  

UK PubMed Central (United Kingdom)

The biosynthesis of insect juvenile hormone (JH) and its neuroendocrine control are attractive targets for chemical control of insect pests and vectors of disease. To facilitate the molecular...Full Text Available

2006-04-01

212

Cholinergic modulation of multivesicular release regulates striatal synaptic potency and integration  

UK PubMed Central (United Kingdom)

The pleiotropic actions of neuromodulators on pre- and postsynaptic targets present challenges to disentangling the mechanisms underlying regulation of synaptic transmission. Within the striatum,...Full Text Available

2009-09-01

213

Bacterial flora-typing with targeted, chip-based Pyrosequencing  

UK PubMed Central (United Kingdom)

BackgroundThe metagenomic analysis of microbial communities holds the potential to improve our understanding of the role of microbes in clinical conditions. Recent, dramatic improvements...Full Text Available

214

Approaches to the evaluation of chemical-induced immunotoxicity.  

UK PubMed Central (United Kingdom)

The immune system plays a crucial role in maintaining health; however, accumulating evidence indicates that this system can be the target for immunotoxic effects caused by a variety of chemicals including...Full Text Available

1995-12-01

215

An Extended Kalman Filter for Use in a Shared Aperture ...  

Science.gov (United States)

... used to track a point source target ... A one sigma tracking error of .2 ... LOOKING INFRARED SYSTEMS, *KALMAN FILTERING, SIGNAL PROCESSING ...

1978-12-01

216

A comprehensive assessment of N-terminal signal peptides prediction methods  

UK PubMed Central (United Kingdom)

BackgroundAmino-terminal signal peptides (SPs) are short regions that guide the targeting of secretory proteins to the correct subcellular compartments in the cell. They are cleaved...Full Text Available

217

X-ray zone plate fabrication using a focused ion beam  

Energy Technology Data Exchange (ETDEWEB)

An x-ray zone plate was fabricated using the novel approach of focused ion beam (FIB) milling. The FIB technique was developed in recent years, it has been successfully used for transmission electron microscopy (TEM) sample preparation, lithographic mask repair, and failure analysis of semiconductor devices. During FIB milling, material is removed by the physical sputtering action of ion bombardment. The sputter yield is high enough to remove a substantial amount of material, therefore FIB can perform a direct patterning with submicron accuracy. The authors succeeded in fabricating an x-ray phase zone plate using the Micrion 9500HT FIB station, which has a 50 kV Ga{sup +} column. Circular Fresnel zones were milled in a 1.0-{micro}m-thick TaSiN film deposited on a silicon wafer. The outermost zone width of the zone plate is 170 nm at a radius of 60 {micro}m. An achieved aspect ratio was 6:1.

2000-08-16

218

The Mechanical Properties of Alumina Films Formed by Plasma Deposition and by Ion Irradiation of Sapphire  

Energy Technology Data Exchange (ETDEWEB)

This paper examines the correlation between mechanical properties and the density, phase, and hydrogen content of deposited alumina layers, and compares them to those of sapphire and amorphous alumina synthesized through ion-beam irradiation of sapphire. Alumina films were deposited using electron beam evaporation of aluminum and co-bombardment with O{sub 2}{sup +} ions (30-230 eV) from an electron cyclotron resonance (ECR) plasma. The H content and phase were controlled by varying the deposition temperature and the ion energy. Sapphire was amorphized at 84 K by irradiation with Al and O ions (in stoichiometric ratio) to a defect level of 4 dpa in order to form an amorphous layer 370 nm thick. Nanoindentation was performed to determine the elastic modulus, yield strength and hardness of all materials. Sapphire and amorphized sapphire have a higher density and exhibit superior mechanical properties in comparison to the deposited alumina films. Density was determined ...

1999-07-16

219

Radiation hardening of final optics for an ICF reactor  

International Nuclear Information System (INIS)

Radiation damage of the final optical components in an Inertial Confinement Fusion (ICF) reactor is a crucial issue for development of a laser-fusion reactor. To some extent, this problem will be encountered in the National Ignition Facility (NIF), but there, the integrated radiation dose will be considerably less than that encountered in a future reactor. This extremely harsh radiation environment necessitates shielding the ICF optics from direct neutron and x-ray bombardment. Several approaches have been suggested, such as the use of grazing incidence metal mirrors or fused silica wedge deflectors. While metal mirrors can withstand a larger radiation dose, their focusing qualities pose problems. Therefore wedge deflectors, originally suggested by Lawrence Livermore National Laboratory (LLNL) staff, represent a promising alternative. Radiation hardening of the fused silica deflectors using a new combined thermal/optical annealing approach is examined here as a ...

1995-04-24

220

Production of atomic negative ion beams of the Group IA elements  

Energy Technology Data Exchange (ETDEWEB)

A method has been developed which enables the direct sputter generation of atomic negative ion beams of all members of the Group IA elements (Li, Na, K, Rb, and Cs). The method consists of the use of sputter samples formed by pressing mixtures of the carbonates of the Group IA elements and 10% (atomic) Cu, Ag, or other metal powder. The following intensities are typical of those observed from carbonate samples subjected to /approximately/3 KeV cesium ion bombardment: Li/sup -/: greater than or equal to0.5 ..mu..A; Na/sup -/: greater than or equal to0.5 ..mu..A; K/sup -/: greater than or equal to0.5 ..mu..A; Rb/sup -/: greater than or equal to0.5 ..mu..A; Cs/sup -/: greater than or equal to0.2 ..mu..A. 7 refs., 2 figs., 1 tab.

1988-01-01

221

Plasma immersion ion implantation (PIII) of metals; Plasmaimmersionsionenimplantation metallischer Werkstoffe  

Energy Technology Data Exchange (ETDEWEB)

Plasma Immersion Ion Implantation (PIII) is a new hybrid technology for surface treatment of materials based on the principles of plasma nitriding and ion implantation. The equipment and the operation of the system are introduced. As well as providing an alternate method of ion implantation, it is possible to combine energetic ion bombardment with plasma nitriding. Different metal materials and treatment conditions have been studied. The capability of PIII-treatment to improve the properties of a wide range of metals has been proven. Application for forming tools and their industrial test has been successful. (orig.) [Deutsch] Die Plasmaimmersionsimplantation (PIII) ist eine neue Hybridtechnologie zur Behandlung von Werkstoffoberflaechen und basiert auf den Prinzipien des Plasmanitrierens und der Ionenimplantation. Die Anlagentechnik und die Arbeitsweise werden vorgestellt. Verfahrensspezifische Vorteile entstehen durch die Moeglichkeit, sowohl alternative ...

1995-01-01

222

Optical and structural properties of Ge films from ion-assisted deposition  

International Nuclear Information System (INIS)

The optical properties and microstructure of germanium (Ge) films, prepared by ion-assisted deposition (IAD) process, were investigated. The Ge films were deposited on sapphire and silicon substrates, with and without simultaneous Ar+ bombardment. Higher index films, with a refractive index 7.7% larger than that of the single crystalline Ge wafer, were obtained with the IAD process. The density of the IAD film could be 1.5% greater than that of the e-beam film. The results of the heat treatment indicated that the optical and structural properties of the IAD films were more stable. Ge nano-crystallites could be observed under high ion power density, which induced a crystalline structure in the Ge thin films. The average size of the nano-crystallites, as determined from both the X-ray diffraction data and the transmission electron microscopy images, showed that no systematic change had occurred. The results presented in this work suggest that the optical and ...

2008-11-28

223

Novel non-discoid chiral copper(II)-salen type [N2O2] donor Schiff base complexes with a cyclohexane diamine spacer: synthesis, electrochemistry, columnar mesomorphism and DFT study  

British Library Electronic Table of Contents (United Kingdom)

A series of new non-discoid chiral copper(ii)-salen type complexes, [Cu((4-CnH2n+1O)2salen)], n = 14, 16, 18 and salen = N,N'-cyclohexane bis (salicylideneiminato), containing 4-substituted alkoxy tails in the side aromatic rings and a cyclohexane spacer, have been prepared and their mesogenic properties investigated. The compounds were characterised by Fourier transform infra-red spectroscopy, 1H and 13C nuclear magnetic resonance spectroscopy, UV-vis spectroscopy and fast atom bombardment mass spectrometry. Mesomorphic properties of these compounds were studied by polarising optical microscopy, differential scanning calorimetry and X-ray diffraction (XRD). The ligands are non-mesogenic but the complexes exhibited enantiotropic rectangular columnar mesophases (Colr) with extended temperat...

2011-01-01

224

New intelligent monitor for CANDU type NPP  

International Nuclear Information System (INIS)

Nuclear energy provides a third of Europe's electricity with nearly no greenhouse-gas emissions. Sustained efforts are now being conducted to harmonize regulations all over Europe through WENRA and to converge on technical nuclear safety practices within the TSO network ETSON (European Technical Safety Organizations Network). In CANDU type NPP the tritiated water occurs by the neutron bombardment of deuterium. The tritiated water vapors imply health hazard (in the critical organs of the body the water presents a 10 day average biological half-life) and the early detection in nuclear plants of tritium emissions is important because the tritiated water vapors have the same characteristics as of atmospheric water vapors. By detecting tritiated vapors, the monitoring system ensures the following objectives: (a) indicates levels of tritium generally due to heavy water leakage, (b) reduces the possibility of health hazard. In order to attain this goal of safety function, ...

2009-10-12

225

New developments in plasma nitriding: Outcomes of AINSE collaborations  

International Nuclear Information System (INIS)

As a hardening process, the attractiveness of nitriding lies in its low treatment temperature. Although the thickness of the case is less than that obtained by higher temperature processes such as carburising, there are a range of alloys and applications for which nitriding is the only possible alternative. Indeed, there are some alloys and applications for which even the normal nitriding temperatures (between 500 deg C and 600 deg C for ferrous alloys) are too high. In this paper, we report on developments, specifically the use of low pressure plasmas and high energy ion bombardment, which can extend the benefits of nitriding to lower temperatures. In this poster, we will present results from these collaborative projects, concentrating on the nitriding of austenitic stainless steel at temperatures below 450 deg C. In this temperature range, the hardness and wear resistance of the surface can be improved without compromising the corrosion resistance of the ...

1998-12-02

226

Micro and nano patterning by focused ion beam enhanced adhesion  

International Nuclear Information System (INIS)

We report a new method of generating nano and micro patterns using focused ion beam (FIB) induced adhesion. The method utilizes selective irradiation of thin metallic films grown on substrates by focused ion beam followed by peel off. After peel off of the irradiated thin film it is observed that the ion beam scanned portions are retained on the substrate, creating nano and micro patterns. The method is suitable for materials of which the adhesion to the substrate can be improved by ion bombardment. The phenomenon has been demonstrated by creating gold nano patterns of different shapes and sizes ranging from 500 nm to 5 #mu#m on SiO_2-Si substrate using 10-30 keV Ga FIB at beam currents up to 10 pA. The mechanism involved in the process has been discussed. The technique could be utilized to prepare micro and nano patterns of thin films deposited on an appropriate substrate for optical, plasmonic and sensor related applications.

2009-05-01

227

M X-ray production in Nd, Gd, Ho and Lu by 1-6 MeV lithium ions  

Energy Technology Data Exchange (ETDEWEB)

M-shell X-rays of the rare-earth elements {sub 60}Nd, {sub 64}Gd, {sub 67}Ho and {sub 71}Lu were measured for lithium ion bombardment in the energy range 1.0-6.0 MeV. The M-shell X-rays with energies of 0.978-1.631 keV were detected with a LINK analytical detector. The efficiency of the detector was determined by using the known atomic-field bremsstrahlung cross-sections from low energy electron beams and K-shell X-ray measurements with light projectiles. The measured cross-sections are compared to the predictions of the first Born approximation and the ECPSSR (energy loss and Coulomb deflection effects, perturbed stationary state approximation with relativistic correction) theories. The best theoretical description of the present data is given by the ECPSSR theory, even though the discrepancy between data and theory is increasing at higher projectile energies.

2004-06-01

228

Kapitza conductance of the (100) surface of copper  

International Nuclear Information System (INIS)

Measurements of the Kapitza conductance to liquid helium II across the (100) surface of single crystals of copper are presented. The temperature range of these measurements was 1.6-- 2.1 K. The sample surfaces were subjected to several different treatments. Some surfaces were cleaned by low-energy argon ion bombardment, annealed in an ultrahigh-vacuum system, and preserved under vacuum until purified liquid helium was admitted. Other surfaces were intentionally damaged by machining and/or exposure to the atmosphere. The conductance after these latter treatments was found to be about a factor of three higher than that of the more ideally cleaned and annealed surfaces, and a significant difference in the temperature dependence of the conductance was also observed. Conductances were reproducible for similarly treated surfaces and correlated with surface damage determined by x-ray diffraction. The relationship of these results to the numerous current theories of the ...

229

Ion beam mixing in Fe/Si and Ta/Si bilayers: Possible effects of ion charges  

Energy Technology Data Exchange (ETDEWEB)

Thin Fe and Ta layers of 30-45 nm thickness, deposited via magnetron sputtering on Si (1 0 0) substrates, were bombarded at room temperature with 100 keV Ar{sup 1+} or Ar{sup 8+} or with 250 keV Xe{sup 1+} or Xe{sup 19+} ions in order to test the influence of the ion charge state on the surface sputtering and interface mixing. The samples were characterized by means of Rutherford backscattering at 0.9-3.0 MeV {alpha}-particle energy, time-of-flight elastic recoil detection analysis with a 53 MeV {sup 127}I{sup 10+} beam and atomic force microscopy. No influence of the charge state on the sputtering and athermal mixing rate was observed in the case of the Ta/Si system. However, in the case of the Fe/Si system, the ion charge was observed to have an influence on the mixing rate.

2003-05-01

230

Growth of single-crystal metastable semiconducting (GaSb)_1/sub -//sub x/Ge/sub x/ films  

International Nuclear Information System (INIS)

Epitaxial metastable (GaSb)/sub 1-x/Ge/sub x/ alloys with compostions across the pseudobinary phase diagram have been grown on (100) GaAs substrates by multitarget rf sputtering. An essential feature allowing the growth of these metastable materials was low-energy ion bombardment of the growing film during deposition to enhance surface diffusion, promote mixing, and preferentially sputter incipient second-phase precipitates. Annealing experiments indicated that the metastable films exhibit good high-temperature stability and that they transform through a continuous series of GaSb-rich and Ge-rich phases in which the solute concentrations decrease until the equilibrium two-phase alloy is obtained. While the calculated free-energy difference between the single-phase metastable and equilibrium states is approx.18 meV, the measured activation barrier for the transformation is approx.3 eV. All films were p-type with room-temperature hole concentrations varying from ...

6180-01-01

231

Generation of proton-induced nuclear reaction data for C, Fe, Cu and Pb and their benchmark with a deterministic transport code KASKAD-S  

International Nuclear Information System (INIS)

The new proton-induced nuclear reaction data for C, Fe, Cu and Pb for KASKAD-S have been generated using a newly developed data preparation system. The new system utilizes the NJOY and TRANSX codes to prepare these data with the latest evaluation instead of using the SADCO code with the built-in nuclear data. Auxiliary codes have been developed to help the conversion of TRANSX output into the reaction data for running the KASKAD-S. The basic nuclear data selected for this work are the LA150 and KAERI high energy files whose energy ranges are up to 150 and 250 MeV, respectively. The total neutron yields were calculated using KASKAD-S and the new reaction data up to 250 MeV bombarding energy. The calculations were compared with the measurements or MCNPX calculations when the measured data were absent. The comparison shows that our calculations give an overall good agreement with the measurements and MCNPX calculations except around 30 MeV where large discrepancies ...

2003-10-01

232

Fusion power and the environment  

Science.gov (United States)

Environmental characteristics of conceptual fusion-reactor systems based on magnetic confinement are examined quantitatively, and some comparisons with fission systems are made. Fusion, like all other energy sources, will not be completely free of environmental liabilities, but the most obvious of these-- tritium leakage and activation of structural materials by neutron bombardment-- are susceptible to significant reduction by ingenuity in choice of materials and design. Large fusion reactors can probably be designed so that worst-case releases of radioactivity owing to accident or sabotage would produce no prompt fatalities in the public. A world energy economy relying heavily on fusion could make heavy demands on scarce nonfuel materials, a topic deserving further attention. Fusion's potential environmental advantages are not entirely ''automatic'', converting them into practical reality will ...

1975-06-01

233

Focused ion beam techniques for fabricating geometrically-complex components and devices.  

Energy Technology Data Exchange (ETDEWEB)

We have researched several new focused ion beam (FIB) micro-fabrication techniques that offer control of feature shape and the ability to accurately define features onto nonplanar substrates. These FIB-based processes are considered useful for prototyping, reverse engineering, and small-lot manufacturing. Ion beam-based techniques have been developed for defining features in miniature, nonplanar substrates. We demonstrate helices in cylindrical substrates having diameters from 100 {micro}m to 3 mm. Ion beam lathe processes sputter-define 10-{micro}m wide features in cylindrical substrates and tubes. For larger substrates, we combine focused ion beam milling with ultra-precision lathe turning techniques to accurately define 25-100 {micro}m features over many meters of path length. In several cases, we combine the feature defining capability of focused ion beam bombardment with additive techniques such as evaporation, sputter deposition and electroplating in order to ...

2004-03-01

234

Experimental and theoretical studies of nuclear generation of ozone from oxygen and oxygen--sulfur hexafluoride mixtures  

International Nuclear Information System (INIS)

A series of experimental measurements of the yield of O_3 in nuclear-induced O_2 and O_2-SF_6 discharges are reported. The discharges were created by bombardment with energetic particles from the "1"0B(n,#alpha#)"7Li reaction. Continuous irradiation at dose rates of 10"1"5--10"1"7 eV cm"-"3 s"-"1 and pulsed irradiation (--10 ms FWHM) at a peak dose rate of --10"2"0 eV cm"-"3 s"-"1 were conducted. At the lower dose rates, the addition of SF_6 generally increased the ozone yield due to the slowing of ozone destruction by negative oxygen and ozone ions. In contrast, at the high dose rates, the ozone concentration decreased due to SF_6 suppression of atomic oxygen formation by ion--ion recombination. A numerical model was developed and tested against experimental conditions. This model indicates that the steady-state ozone concentration was limited by the reaction O"-_3+O_3#->#2O_2+O"-_2 with a rate coefficient of --1 x 10"-"1"2 cm"3 s"-"1. In addition to dose rate ...

235

Electron and ion beam effects in amorphous SiO_2 and Si_3N_4 films for electronic devices  

International Nuclear Information System (INIS)

The effect of electron and ion beam irradiation on the Sisub(LVV) Auger spectra of SiO_2, Si_3N_4 and Si-oxynitride films was measured by the relative intensity of the 92 eV signal, characteristic for the formation of 'free' silicon during irradiation. While in Si-oxynitride the beam effects were almost negligible, some damage was found in Si_3N_4, but SiO_2 appeared to be extremely sensitive for electron and ion beam irradiation. By low energy electron loss spectroscopy of ion bombarded SiO_2 and Si_3N_4 films new electron states due to broken Si-O and Si-N bonds could be determined within the band gap of the insulators. The measured energy losses were interpreted by means of electron energy level schemes of the amorphous films. (author).

1982-01-01

236

Electron and ion beam effects in amorphous SiO/sub 2/ and Si/sub 3/N/sub 4/ films for electronic devices  

Energy Technology Data Exchange (ETDEWEB)

The effect of electron and ion beam irradiation on the Sisub(LVV) Auger spectra of SiO/sub 2/, Si/sub 3/N/sub 4/ and Si-oxynitride films was measured by the relative intensity of the 92 eV signal, characteristic for the formation of 'free' silicon during irradiation. While in Si-oxynitride the beam effects were almost negligible, some damage was found in Si/sub 3/N/sub 4/, but SiO/sub 2/ appeared to be extremely sensitive for electron and ion beam irradiation. By low energy electron loss spectroscopy of ion bombarded SiO/sub 2/ and Si/sub 3/N/sub 4/ films new electron states due to broken Si-O and Si-N bonds could be determined within the band gap of the insulators. The measured energy losses were interpreted by means of electron energy level schemes of the amorphous films.

1982-10-01

237

Electrical breakdown at low pressure in the presence of a weak magnetic field  

Energy Technology Data Exchange (ETDEWEB)

Electron trapping in crossed electric and magnetic fields is an important mechanism by which electrical discharges can develop in low pressure gases. The authors report observations of discharges produced by this mechanism around a spherical anode in two space simulation chambers, namely the Space Plasma Interaction Experiment (SPIE) at the University of Maryland, and the NASA-Lewis B-2 chamber. They have identified two types of discharges in these experiments. In the B-2 chamber, the breakdown takes the form of a runaway dischage with spherical topology, limited only by the ability of the power supply to provide the current. In the SPIE chamber this type of discharge also occurs, in addition to a low current toroidal discharge which is observed at higher magnetic fields. They present measurements of both types of discharge and show how the trapping effect of the magnetic field together with secondary electron emission by high energy ion bombardment of the chamber ...

1990-05-01

238

Effects of post-irradiation annealing in alpha-particle bombarded molybdenum  

International Nuclear Information System (INIS)

Structural variations in 39-MeV alpha-particle irradiated (Tsub(irr) = 60 deg C) polycrystalline molybdenum during post-irradiation annealing were studied by X-ray and TEM methods. Despite the high density of irradiation induced defects in the structure of the specimen X-ray measurements showed zero relative lattice parameter change after an irradiation dose of 1.1 x 10"-_2 dpa. However, during the annealing #delta#a/a was changed in the positive range, exhibiting two peaks - at 100 and 300 deg C - whereas the damage structure detected by TEM indicated no changes. Analysis of the results leads to the conclusion that in the range 100 to 250 deg C migration of isolated vacancies and their annihilation at interstitial clusters as well as possible formation of new vacancy clusters occur. The second peak on the #delta#a/a temperature dependence curve is related to the transformation (probably, thermal disintegration) of vacancy clusters formed at energetic displacement cascades during ...

239

Effective removal of Ga residue from focused ion beam using a plasma cleaner  

International Nuclear Information System (INIS)

Samples prepared using the focused ion beam (FIB) inevitably contain the surface damage induced by energetic Ga"+ ions. An effective method of removing the surface damage is demonstrated using a plasma cleaner, a device which is widely used to minimize the surface contamination in scanning transmission electron microscopy (STEM). Surface bombardment with low-energy Ar"+ ions was induced by biasing the sample immersed in the plasma source, so as to etch off the surface materials. The etch rates of SiO_2, measured with a bias voltage of 100-300 V, were found to vary linearly with both the time and bias and were able to be controlled from 1.4 to 9 nm/min. The removal of the Ga residue was confirmed using energy dispersive spectroscopy (EDS) after the plasma processing of the FIB-prepared sample. When the FIB-prepared sample was processed via plasma etching for 10 min with a bias of 150 V, the surface Ga damage was completely removed.

240

ESR dating of fault rocks  

Energy Technology Data Exchange (ETDEWEB)

Past movement on faults can be dated by measurement of the intensity of ESR signals in quartz. These signals are reset by local lattice deformation and local frictional heating on grain contacts at the time of fault movement. The ESR signals then grow back as a result of bombardment by ionizing radiation from surrounding rocks. The age is obtained from the ratio of the equivalent dose, needed to produce the observed signal, to the dose rate. Fine grains are more completely reset during faulting, and a plot of age vs. grain size shows a plateau for grains below critical size; these grains are presumed to have been completely zeroed by the last fault activity. We carried out ESR dating of fault rocks collected near the Gori nuclear reactor. Most of the ESR signals of fault rocks collected from the basement are saturated. This indicates that the last movement of the faults had occurred before the Quaternary period. However, ESR dates from the Oyong fault zone range ...

2003-02-15

241

Deposition of Cu film on SiO_2 using a partially ionized beam  

International Nuclear Information System (INIS)

Ion bombardment during deposition can significantly modify the film properties. In the partially ionized beam deposition, ions derived from the depositing material, i.e., the self-ions, are used during deposition. Cu films were deposited on SiO_2 substrates at room temperature using 1% Cu self-ions with an energy ranging between 0--4 keV. We studied the microstructures of the Cu films using x-ray diffraction and transmission electron microscopy, measured the impurity level inside the films using secondary ion mass spectrometry, and performed the resistivity measurements using a four point probe. The results indicate that there is an optimum ion energy around 2 keV at which, the integrated x-ray intensity ratio I(111)/I(200) reaches its maximum value indicating a strong left-angle 111 right-angle texture, while the impurity concentration and resisitivity are minimum. The correlation between the structural, compositional and electrical properties are discussed in the ...

1990-01-01

242

Deposition of Cu film on SiO sub 2 using a partially ionized beam  

Energy Technology Data Exchange (ETDEWEB)

Ion bombardment during deposition can significantly modify the film properties. In the partially ionized beam deposition, ions derived from the depositing material, i.e., the self-ions, are used during deposition. Cu films were deposited on SiO{sub 2} substrates at room temperature using 1% Cu self-ions with an energy ranging between 0--4 keV. We studied the microstructures of the Cu films using x-ray diffraction and transmission electron microscopy, measured the impurity level inside the films using secondary ion mass spectrometry, and performed the resistivity measurements using a four point probe. The results indicate that there is an optimum ion energy around 2 keV at which, the integrated x-ray intensity ratio {ital I}(111)/{ital I}(200) reaches its maximum value indicating a strong {l angle}111{r angle} texture, while the impurity concentration and resisitivity are minimum. The correlation between the structural, compositional and electrical properties are ...

1990-05-01

243

Deposition of Cu film on SiO sub 2 using a partially ionized beam  

Science.gov (United States)

Ion bombardment during deposition can significantly modify the film properties. In the partially ionized beam deposition, ions derived from the depositing material, i.e., the self-ions, are used during deposition. Cu films were deposited on SiO{sub 2} substrates at room temperature using 1% Cu self-ions with an energy ranging between 0--4 keV. We studied the microstructures of the Cu films using x-ray diffraction and transmission electron microscopy, measured the impurity level inside the films using secondary ion mass spectrometry, and performed the resistivity measurements using a four point probe. The results indicate that there is an optimum ion energy around 2 keV at which, the integrated x-ray intensity ratio {ital I}(111)/{ital I}(200) reaches its maximum value indicating a strong {l angle}111{r angle} texture, while the impurity concentration and resisitivity are minimum. The correlation between the structural, compositional and electrical properties are ...

1990-05-01

244

Brain imaging agents: synthesis and characterization of (N-piperidinylethyl) hexamethyl diaminodithiolate oxo technetium(V) complexes  

Energy Technology Data Exchange (ETDEWEB)

Two sup(99m)Tc complexes of (N-piperidinylethyl) hexamethyl diaminodithiol (NEP-DADT) have shown high brain uptake in rodents and lower primates. One of these sup(99m)Tc complexes has given positive images of the brain in man which are qualitatively related to regional brain blood flow (rCBF). In order to determine the structure of these sup(99m)Tc products, the corresponding /sup 99/Tc(NEP-DADT) complexes were prepared and characterized by HPLC, TLC, fast-atom-bombardment mass spectrometry (FAB MS) and other analytical techniques. These results indicate that the two /sup 99/Tc (NEP-DADT) complexes are syn and anti isomers (i.e. one isomer has the N-piperdinylethyl side chain located syn to the technetium oxo core while the other has this side chain located anti to the technetium oxo core).

1987-01-01

245

Brain imaging agents: synthesis and characterization of (N-piperidinylethyl) hexamethyl diaminodithiolate oxo technetium(V) complexes  

International Nuclear Information System (INIS)

Two sup(99m)Tc complexes of (N-piperidinylethyl) hexamethyl diaminodithiol (NEP-DADT) have shown high brain uptake in rodents and lower primates. One of these sup(99m)Tc complexes has given positive images of the brain in man which are qualitatively related to regional brain blood flow (rCBF). In order to determine the structure of these sup(99m)Tc products, the corresponding "9"9Tc(NEP-DADT) complexes were prepared and characterized by HPLC, TLC, fast-atom-bombardment mass spectrometry (FAB MS) and other analytical techniques. These results indicate that the two "9"9Tc (NEP-DADT) complexes are syn and anti isomers (i.e. one isomer has the N-piperdinylethyl side chain located syn to the technetium oxo core while the other has this side chain located anti to the technetium oxo core). (author).

246

Alpha particle spectroscopic strengths for levels populated in the "2"0 "2"1 "2"2Ne("6Li, d)"2"4 "2"5 "2"6Mg reactions  

International Nuclear Information System (INIS)

The "2"0 "2"1 "2"2Ne("6Li, d)"2"4 "2"5 "2"6Mg reactions have been studied at a bombarding energy of 32 MeV. Alpha particle spectroscopic strengths have been extracted for several low-lying levels by a finite-range distorted wave analysis. These are compared with theoretical predictions. The agreement is good both for relative strengths to different levels within a nucleus and for ground-state strengths relative to the "1"6O("6Li, d) result. Strengths calculated using eigenfunctions determined in large shell-model computations agree well with pure symmetry SU(3) predictions. The "2"1Ne("6Li, d) angular distributions for transitions to the ground-state band of "2"5Mg are characterized by the lower of the two L-transfers allowed for populating each level. For the 3"+(5.24 MeV) unnatural parity level in "2"4Mg, a two-step calculation gives a better account of the data than does a compound nuclear calculation. (Auth.).

247

Testing of CFC Targets by Plasma Heat Fluxes Relevant to Elms and Mitigated Disruptions in ITER  

International Nuclear Information System (INIS)

Carbon fibre composite (CFC) was irradiated by hot plasma streams at plasma gun facility MK-200UG. The CFC targets were tested by plasma loads relevant to Edge Localized Modes (ELM) and mitigated disruptions in ITER. Onset condition of CFC evaporation and properties of evaporated carbon were studied by use of infrared pyrometry and visible spectroscopy.

2006-01-01

248

Targeted suppression of Has2 mRNA in mouse cumulus cell-oocyte complexes by adenovirus-mediated short-hairpin RNA expression  

UK PubMed Central (United Kingdom)

RNA interference (RNAi) is an effective tool for studying gene function in oocytes, but no studies have targeted somatic cells of primary cultured cumulus cell-oocyte complexes (COCs). This...Full Text Available

2009-06-01

249

Targeted Capture and Next-Generation Sequencing Identifies C9orf75, Encoding Taperin, as the Mutated Gene in Nonsyndromic Deafness DFNB79  

UK PubMed Central (United Kingdom)

Targeted genome capture combined with next-generation sequencing was used to analyze 2.9 Mb of the DFNB79 interval on chromosome 9q34.3, which includes 108 candidate genes. Genomic...Full Text Available

2010-03-12

250

Structure functions at low Q^2: higher twists and target mass effects  

Energy Technology Data Exchange (ETDEWEB)

We review the physics of structure functions at low Q{sup 2}, focusing on the phenomenon of quark-hadron duality and the resonance-scaling transition, both phenomenologically and in the context of quark models. We also present a new implementation of target mass corrections to nucleon structure functions which, unlike existing treatments, has the correct kinematic threshold behavior at finite Q{sup 2} in the x -> 1 limit.

2006-05-22

251

Production of "2"0"3Pb by proton irradiation of Bi  

International Nuclear Information System (INIS)

Production of lead-203 by proton irradiation of bismuth metal has been investigated as a replacement method for commercially available lead-203. Targets of bismuth metal (0.1 cm thick) were irradiated for periods of 1-3 hours with 90 MeV protons. After processing of the target, the estimated yield of lead-2-3 was 30 millicuries/microamp.

1990-06-24

252

PV Conversion Technologies, Session: OPV, Sensitized, Seed (Presentation)  

Energy Technology Data Exchange (ETDEWEB)

The NREL Sensitized Solar Cell (SSC) Core Program supports the Solar America Initiative by: (1) targeting new devices and processes for commercialization by 2015 that are less expensive, more efficient, highly reliable, and environmentally benign; (2) collaborating with DOE OS/BES to conduct basic research targeting breakthroughs in key areas, such as ultra-high efficiency and/or ultra-low cost materials and devices.

2008-04-01

253

Modeled Neutron Induced Nuclear Reaction Cross Sections for Radiochemistry in the region of Iridium and Gold  

International Nuclear Information System (INIS)

We have developed a set of modeled nuclear reaction cross sections for use in radiochemical diagnostics. Systematics for the input parameters required by the Hauser-Feshbach statistical model were developed and used to calculate neutron induced nuclear reaction cross sections for targets ranging from osmium (Z = 76) to gold (Z = 79). Of particular interest are the cross sections on Ir and Au including reactions on isomeric targets.

2008-02-01

254

Kidney-specific allo- and autoantibodies in the alloantibody response to rat kidney: the use of kidney homogenate as a target for serological analysis.  

UK PubMed Central (United Kingdom)

LEW anti-DA kidney and DA anti-LEW kidney sera were assayed using an indirect 125I anti-immunoglobulin-binding assay with kidney homogenate as target. This allowed the full spectrum of antibodies to...Full Text Available

1980-04-01

255

In vitro atrazine-exposure inhibits human natural killer cell lytic granule release  

International Nuclear Information System (INIS)

The herbicide atrazine is a known immunotoxicant and an inhibitor of human natural killer (NK) cell lytic function. The precise changes in NK cell lytic function following atrazine exposure have not been fully elucidated. The current study identifies the point at which atrazine exerts its affect on the stepwise process of human NK cell-mediated lyses of the K562 target cell line. Using intracellular staining of human peripheral blood lymphocytes, it was determined that a 24-h in vitro exposure to atrazine did not decrease the level of NK cell lytic proteins granzyme A, granzyme B or perforin. Thus, it was hypothesized that atrazine exposure was inhibiting the ability of the NK cells to bind to the target cell and subsequently inhibit the release of lytic protein from the NK cell. To test this hypothesis, flow cytometry and fluorescent microscopy were employed to analyze NK cell-target cell co-cultures following atrazine ...

2007-06-01

256

Highly efficient gene silencing using perfect complementary artificial miRNA targeting AP1 or heteromeric artificial miRNA targeting AP1 and CAL genes  

UK PubMed Central (United Kingdom)

Gene silencing is a useful technique for elucidating biological function of genes by knocking down their expression. A recently developed artificial microRNAs (amiRNAs) exploits an endogenous...Full Text Available

2009-03-01

257

Electron accelerator unit for electron beam therapy  

Energy Technology Data Exchange (ETDEWEB)

An electron accelerator unit is described for electron beam therapy, comprising: a source of an electron beam; means for finally directing at least a portion of the beam to a therapy site, the directing means being mechanically independent of, and electrically isolated from, the source, and having a target area; and means for aligning the source with the directing means, the aligning means comprising means for projecting at least one beam of light from the source toward the target area.

1987-01-27

258

Electron accelerator unit for electron beam therapy  

International Nuclear Information System (INIS)

An electron accelerator unit is described for electron beam therapy, comprising: a source of an electron beam; means for finally directing at least a portion of the beam to a therapy site, the directing means being mechanically independent of, and electrically isolated from, the source, and having a target area; and means for aligning the source with the directing means, the aligning means comprising means for projecting at least one beam of light from the source toward the target area.

259

Double-electron-capture cross section for I/sup +/ in a magnesium-vapor target  

Energy Technology Data Exchange (ETDEWEB)

Measurements of the double-electron-capture process in which a positive ion of iodine becomes a negative ion in a single collision with a magnesium atom are reported between 20 and 90 keV. The cross section is comparable to that for the rare gases and not as large as might be expected from a two-valence-electron atom. This process is probably insignificant in the production of negative ion beams using a magnesium-vapor target.

1987-06-15

260

Development of High-Efficiency Low-Lift Vapor Compression System - Final Report  

Energy Technology Data Exchange (ETDEWEB)

PNNL, with cofunding from the Bonneville Power Administration (BPA) and Building Technologies Program, conducted a research and development activity targeted at addressing the energy efficiency goals targeted in the BPA roadmap. PNNL investigated an integrated heating, ventilation and air conditioning (HVAC) system option referred to as the low-lift cooling system that potentially offers an increase in HVAC energy performance relative to ASHRAE Standard 90.1-2004.

2010-03-31

261

Designing Human m1 Muscarinic Receptor-Targeted Hydrophobic Eigenmode Matched Peptides as Functional Modulators  

UK PubMed Central (United Kingdom)

A new proprietary de novo peptide design technique generated ten 15-residue peptides targeting and containing the leading nontransmembrane hydrophobic autocorrelation wavelengths, “modes”,...Full Text Available

2004-03-01

262

Achieving cholesterol targets by individualizing starting doses of statin according to baseline low-density lipoprotein cholesterol and coronary artery disease risk category: The CANadians Achieve Cholesterol Targets Fast with Atorvastatin Stratified Titration (CanACTFAST) study  

UK PubMed Central (United Kingdom)

BACKGROUND:Despite an increasing body of evidence on the benefit of lowering elevated levels of low-density lipoprotein cholesterol (LDL-C), there is still considerable concern that...Full Text Available

2010-02-01

263

A bioinformatics tool for linking gene expression profiling results with public databases of microRNA target predictions  

UK PubMed Central (United Kingdom)

MicroRNAs are short (∼22 nucleotides) noncoding RNAs that regulate the stability and translation of mRNA targets. A number of computational algorithms have been developed to help predict which...Full Text Available

2008-11-01

264

Radiation inactivation target size of rat adipocyte glucose transporters in the plasma membrane and intracellular pools  

Energy Technology Data Exchange (ETDEWEB)

The in situ assembly states of the glucose transport carrier protein in the plasma membrane and in the intracellular (microsomal) storage pool of rat adipocytes were assessed by studying radiation-induced inactivation of the D-glucose-sensitive cytochalasin B binding activities. High energy radiation inactivated the glucose-sensitive cytochalasin B binding of each of these membrane preparations by reducing the total number of the binding sites without affecting the dissociation constant. The reduction in total number of binding sites was analyzed as a function of radiation dose based on target theory, from which a radiation-sensitive mass (target size) was calculated. When the plasma membranes of insulin-treated adipocytes were used, a target size of approximately 58,000 daltons was obtained. For adipocyte microsomal membranes, we obtained target sizes of approximately 112,000 and 109,000 daltons prior ...

1987-06-15

265

Proton G{sub E}/G{sub M} from beam-target asymmetry  

Science.gov (United States)

The ratio of the proton's electric to magnetic form factor, G{sub E}/G{sub M}, can be extracted in elastic electron-proton scattering by measuring cross sections, beam-target asymmetry, or recoil polarization. Separate determinations of G{sub E}/G{sub M} by cross sections and recoil polarization observables disagree for Q{sup 2}>1 (GeV/c){sup 2}. Measurement by a third technique might uncover an unknown systematic error in either of the previous measurements. The beam-target asymmetry has been measured for elastic electron-proton scattering at Q{sup 2} = 1.51 (GeV/c){sup 2} for target spin orientation aligned perpendicular to the beam momentum direction. This is the largest Q{sup 2} at which G{sub E}/G{sub M} has been determined by a beam-target asymmetry experiment. The result, {mu}G{sub E}/G{sub M}=0.884{+-}0.027{+-}0.029, is compared to previous world data.

2006-09-15

266

One-class classifiers and their application to synthetic aperture radar target recognition  

Energy Technology Data Exchange (ETDEWEB)

Target recognition requires the ability to distinguish targets from non-targets, a capability called one-class generalization. To function as a one-class classifier, a neural network must have three types of generalization: within-class, between-class, and out-of-class. We discuss these three types of generalization and identify neural network architectures that meet these requirements. We have applied our one-class classifier ideas to the problem of automatic target recognition in synthetic aperture radar. We have compared three neural network algorithms: Carpenter and Grossberg`s algorithmic version of the Adaptive Resonance Theory (ART-2A), Kohonen`s Learning Vector Quantization (LVQ), and Reilly and Cooper`s Restricted Columb Energy network (RCE). The ART 2-A neural network has given the best results, with 100% within-class, and out-of-class generalization. Experiments show that the network`s ...

1992-10-01

267

One-class classifier networks for target recognition applications  

Energy Technology Data Exchange (ETDEWEB)

Target recognition requires the ability to distinguish targets from non-targets, a capability called one-class generalization. Many neural network pattern classifiers fail as one-class classifiers because they use open decision boundaries. To function as one-class classifier, a neural network must have three types of generalization: within-class, between-class, and out-of-class. We discuss these three types of generalization and identify neural network architectures that meet these requirements. We have applied our one-class classifier ideas to the problem of automatic target recognition in synthetic aperture radar. We have compared three neural network algorithms: Carpenter and Grossberg`s algorithmic version of the Adaptive Resonance Theory (ART-2A), Kohonen`s Learning Vector Quantization (LVQ), and Reilly and Cooper`s Restricted Coulomb Energy network (RCE). The ART 2-A neural network gives the best ...

1993-01-01

268

Integral cross sections of 50.5 MeV #alpha# particle inelastic scattering on 1p and (2s-1d) shell nuclei and scattering mechanisms  

International Nuclear Information System (INIS)

Obtained experimental data on integral cross sections (ICS) of inelastic scattering of 50.5 MeV #alpha# particles with the excitation of "6","7Li, "9Be, "1"2","1"3C, "1"4C, "1"4N, "2"0Ne, "2"4Mg, "2"8Si nucleus low-lying energy levels are discussed. Regularities, detected in the behaviour of ICS forward scattering for 20-90 deg angles and backscattering for 90-160 deg angles for the target-nucleus under investigation are considered. Effect of reaction open channel number on #alpha#-particle scattering ICS where n,p,d- and #alpha#-channels were considered as the main channels for all the target-nuclei, is discussed. Dependence of #alpha#-particle scattering ICS on the target-nucleus level excitation energy and dependences of reaction open channel number on the channel spin, calculated for 50.5 MeV #alpha# particles and different target nuclei are shown in the diagrams. It is noted that the observed ...

269

Donut-shaped high-dose configuration for proton beam radiation therapy  

Energy Technology Data Exchange (ETDEWEB)

Background: the authors report on the conception and first clinical application of a donut-shaped high-dose configuration for proton therapy (PT). This approach allows one to intensify target volume dose coverage for targets encompassing a critical, dose-limiting structure - like here, the cauda equina -, whilst delivering minimal dose to other healthy structures surrounding the target, thereby reducing the integral dose. Methods and results: intensity-modulated PT methods (IMPT) for spot scanning were applied to create and deliver a donut-shaped high-dose configuration with protons, allowing treating > 75% of the target with at least 95% of the prescribed dose of 72.8 CGE, whilst restricting dose to the cauda equina to 60-65 CGE. Integral dose was lower by a factor of 3.3 as compared to intensity-modulated radiotherapy with photons (IMXT). Conclusion: IMPT and spot scanning technology allow a ...

2005-01-01

270

Donut-shaped high-dose configuration for proton beam radiation therapy  

International Nuclear Information System (INIS)

Background: the authors report on the conception and first clinical application of a donut-shaped high-dose configuration for proton therapy (PT). This approach allows one to intensify target volume dose coverage for targets encompassing a critical, dose-limiting structure - like here, the cauda equina -, whilst delivering minimal dose to other healthy structures surrounding the target, thereby reducing the integral dose. Methods and results: intensity-modulated PT methods (IMPT) for spot scanning were applied to create and deliver a donut-shaped high-dose configuration with protons, allowing treating > 75% of the target with at least 95% of the prescribed dose of 72.8 CGE, whilst restricting dose to the cauda equina to 60-65 CGE. Integral dose was lower by a factor of 3.3 as compared to intensity-modulated radiotherapy with photons (IMXT). Conclusion: IMPT and spot scanning technology allow a ...

2005-01-01

271

Radioactive targets for neutron-induced cross section measurements  

Science.gov (United States)

Measurements using radioactive targets are important for the determination of key reaction path ways associated with the synthesis of the elements in nuclear astrophysics (sprocess), advanced fuel cycle initiative (transmutation of radioactive waste), and stockpile stewardship. High precision capture cross-section measurements are needed to interpret observations, predict elemental or isotopical ratios, and unobserved abundances. There are two new detector systems that are presently being commissioned at Los Alamos National Laboratory for very precise measurements of (n,{gamma}) and (n,f) cross-sections using small quantities of radioactive samples. DANCE (Detector for Advanced Neutron-Capture Experiments), a 4 {pi} gamma array made up of 160 BaF{sub 2} detectors, is designed to measure neutron capture cross-sections of unstable nuclei in the low-energy range (thermal to {approx}500 keV). The high granularity and high detection efficiency of DANCE, combined with ...

2004-01-01

272

Simultaneous production of "2"8Mg and "4"7Ca by high-energy heavy-ion irradiation for applications in biology  

International Nuclear Information System (INIS)

With the aim of preparing carrier-free "2"8Mg and "4"7Ca simultaneously, Ti, V and Fe targets were examined by irradiating with high-energy ions of "1"2C, "1"4N and "1"6O accelerated by the RIKEN ring cyclotron. Among the targets, V gave the highest cross section for the formation of both "2"8Mg and "4"7Ca irrespective of the kind of beams. The cross section for the formation of "2"8Mg by the reactions of Ti, V and Fe targets with ion beams increased in the order of "1"2C<"1"6O<"1"4N. On the other hand, the three beams exhibited almost the same cross sections for the formation of "4"7Ca by the reaction of a given target. Titanium and V were selected as prospective targets and "1"4N as a suitable beam for the production of "2"8Mg and "4"7Ca. Chemical separation procedures of the radiotracers in carrier- and salt-free states have been established by using cation exchange resins. ...

273

Measurement of K x-ray intensity ratio of tin, gadolinium and dysprosium  

International Nuclear Information System (INIS)

Full text: Measurement of K_#beta# to K_#alpha# x-ray intensity ratios are important not only in the field of atomic physics, radiation physics and medical physics, but also to test the validity of assumptions made in the theoretical prediction. The intensity ratios can also give information on the effect of physical and chemical environment of the element in the compound. Many investigators have adopted a single and double reflection geometries to measure the K_#beta# to K_#alpha# x ray intensity ratios to understand the effect of physical and chemical environment on x-ray fluorescence. The targets are excited by a radioactive source of having activity of the order 100 MBq. in order to carry out accurate measurement K_#beta# to K_#alpha# x-ray intensity ratios, we have develop 2#pi# geometrical configuration method : placing a target right on the surface of the detector facing the target to measure the K shell fluorescence ...

2003-11-01

274

Variational method for estimating the rate of convergence of Markov Chain Monte Carlo algorithms  

CERN Document Server

We demonstrate the use of a variational method to determine a quantitative lower bound on the rate of convergence of Markov Chain Monte Carlo (MCMC) algorithms as a function of the target density and proposal density. The bound relies on approximating the second largest eigenvalue in the spectrum of the MCMC operator using a variational principle and the approach is applicable to problems with continuous state spaces. We apply the method to one dimensional examples with Gaussian and quartic target densities, and we contrast the performance of the basic Metropolis-Hastings algorithms with a ``smart'' variant that incorporates gradient information into the trial moves. We find that the variational method agrees quite closely with numerical simulations. We also see that the smart MCMC algorithm often fails to converge geometrically in the tails of the target density except in the simplest case we examine, and even then care ...

2006-01-01

275

Transmission nuclear resonance fluorescence measurements of "2"3"8U in thick targets  

International Nuclear Information System (INIS)

Transmission nuclear resonance fluorescence measurements were made on targets consisting of Pb and depleted U with total areal densities near 86g/cm"2. The "2"3"8U content in the targets varied from 0% to 8.5% (atom fraction). The experiment demonstrates the capability of using transmission measurements as a non-destructive technique to identify and quantify the presence of an isotope in samples with thicknesses comparable to the average thickness of a nuclear fuel assembly. The experimental data also appear to demonstrate the process of notch refilling with a predictable intensity. Comparison of measured spectra to previous backscatter "2"3"8U measurements indicates general agreement in observed excited states. Evidence of two new "2"3"8U excited states and possibly a third state have also been observed.

2011-05-15

276

Targeting the nicotinic alpha7 acetylcholine receptor to enhance cognition in disease  

British Library Electronic Table of Contents (United Kingdom)

A promising drug target currently under investigation to improve cognitive deficits in neuropsychiatric and neurological disorders is the neuronal nicotinic alpha7 acetylcholine receptor (a7nAChR). Improving cognitive impairments in diseases such as Alzheimer's (AD) and schizophrenia remains a large unmet medical need, and the a7nAChR has many properties that make it an attractive therapeutic target. The a7nAChR is a ligand gated ion channel that has particularly high permeability to Ca^2^+ and is expressed in key brain regions involved in cognitive processes (e.g., hippocampus). The a7nAChRs are localized both pre-synaptically, where they can regulate neurotransmitter release, and post-synaptically where they can activate intracellular signaling cascades and influence downstream processes...

2011-01-01

277

Targeted drug delivery under MRI guidance  

British Library Electronic Table of Contents (United Kingdom)

The main goal of local drug delivery is to increase the concentration of a specific therapeutic agent in a target tissue with minimal nontarget distribution. Compared to systemic therapy, local drug delivery provides a high level of therapeutic efficacy with minimal systemic effects. The current primary imaging modality for drug delivery has been x-ray angiography, but it has major limitations including anatomical ambiguity and inability to visualize the targeted tissues. Due to these inherent problems, MR guidance has been explored as an alternative imaging modality for guiding and monitoring of drug therapy. Recently, interventional MR (XMR) systems have been implemented that have both dual x-ray and MRI capabilities in a single suite and allow for real-time interventional procedures to ...

2008-01-01

278

Study on possible fuel layering sequence for FIREX target  

International Nuclear Information System (INIS)

A new procedure of fuel layering for the Fast Ignition Realization Experiment (FIREX) target is proposed. A conical laser guide heating technique was experimentally demonstrated in principle as the followings. It employed the target consisting of a polystyrene (PS) shell, a fill tube and a conical laser guide. At first, liquid fuel was fed into the shell and existed around the conical laser guide because the surface tension of the fuel must cause it. Then, it was solidified. The laser light provided a heat source to the conical laser guide so that the solid fuel was moved to the other interior of the shell. This process resulted in missing solid fuel around the conical laser guide. To fill the vacant space, liquid fuel was added as temperature was raised to the melting point. After the liquid fuel addition, temperature was lowered to the solidification point again. During this process, most of the solid fuel could survive.

2010-08-01

279

Studies on heterogeneous simulated Am targets. Influence of lanthanide oxides  

Energy Technology Data Exchange (ETDEWEB)

Targets for heterogeneous transmutation of americium are composed of a support material, the inert matrix and of an americium oxide compound: AmO{sub 2-x} or Am{sub 2}O{sub 3}. In parallel to the studies using americium, simulated compounds of americium oxide, chosen amongst lanthanide oxides, are used. The selection of these compounds is based on theoretical, physical and crystallochemical considerations. In order to assess the influence of impurities composed of lanthanide oxides, resulting from the separation process, on the physical and chemical properties of such a target, synthesis of oxide powders containing impurities associated with the simulated americium oxide, characterizations, crystallographic studies and sodium compatibility tests have been performed. (author)

1997-12-31

280

Studies of L x-rays from 64 MeV iodine projectiles in collision with gas targets  

International Nuclear Information System (INIS)

We have studied L x-rays from 64 MeV iodine projectile in collision with various gas targets, Z_2 #18, do not arise from selective M subshell vacancy population, has been conclusively established by the observations by Datz et al (1971) and by Saha et al (1996) that the measured intensity ratio of the Ll and L#alpha# lines, which arise because of transitions from different M subshells into the same L, subshell, does not show any periodic behaviour with Z, but stays rather constant. Differences in the measured L#beta#_1/L#alpha# intensity ratio of iodine with 7"+ and 24"+ charge states impinging on Kr target established the minor role of the electrons in the N shell of the projectile in the x-ray production mechanism. (author)

1997-11-17

281

Some properties of atomic beam produced by laser induced ablation of Li target  

International Nuclear Information System (INIS)

Pulsed atomic beams produced in vacuum by laser induced ablation from a lithium target are analyzed by laser induced fluorescence (LIF). The 1-mixing processes induced in the n = 9, 10 Li Rydberg states by collisions with CO_2 molecules illustrate the application of the method. Resolution is limited by the 1 mm diameter of the probe laser beam. Combining LIF and absorption measurements gives n_L_i as a function of time at various distances from the target surface. The investigation of the Li-C0_2 1-mixing process in a heat pipe oven proved impossible due to the high reactivity of Li with C0_2. This problem was solved by renewing the Li atoms at each laser shot. Values obtained for n = 9, n = 10 are k = 17 x 10"-"8 and 15 x 10"-"8 cc/sec, respectively.

282

Separation of {sup 187,188}Pt and {sup 187,188}Ir produced in {sup 11}B{sup 4+} irradiated tantalum target  

Energy Technology Data Exchange (ETDEWEB)

Heavy ion irradiation on tantalum metal target with 57 MeV {sup 11}B{sup 4+} leads to the production of no-carrier-added radioisotopes of platinum, {sup 187,188}Pt and iridium, {sup 187,188}Ir in the matrix, which have been effectively separated from the bulk target and from each other with suitable anion exchangers employing liquid-liquid extraction (LLX). Also {sup 188,189}Pt and {sup 188,189}Ir radionuclides have been produced, from their short-lived precursors {sup 188,189}Au, in {sup 12}C{sup 6+} irradiated tantalum matrix. Gamma-spectroscopy has been utilised to determine the production, extent of separation and purity of the radiotracers at different stages of the experiment. (orig.)

2000-07-01

283

PIC Simulations Of Ion Acceleration By Linearly And Circularly Polarized Laser Pulses  

Science.gov (United States)

Linearly polarized laser radiation accelerates electrons to very high velocities and these electron form a sheath layer on the rear side of thin targets where preferentially protons are accelerated. When mass-limited targets are used, the lateral transport of the absorbed laser energy is reduced and the accelerating field is enhanced. For targets consisting of two ion species, heavier ions facilitate formation of quasi-monoenergetic bunch of lighter ions. For circularly polarized light, fast electron production is suppressed by the absence of the oscillatory component of the ponderomotive force. Ions are accelerated on the front side by the separation field and very thin foil can be accelerated as one massive quasi-neutral block. As all ion species acquire the same velocity, this acceleration mechanism is preferred for heavier ions.

2008-06-24

284

Natural convection cooling of the IFMIF target and test cell  

International Nuclear Information System (INIS)

The present work summarizes efforts on the simulation of natural convection cooling within the IFMIF target and test cell. The simulations have been performed with the STAR-CD code using the k-#omega# high-Reynolds number turbulence model. A dedicated thermohydraulic model has been devised including Lithium loop components. Nuclear heat production has been calculated by the Monte-Carlo code McDeLicious for different parts of the target and test cell walls and was used as input for the STAR-CD simulations. Helium atmospheres at several pressures from 0.1 to 10"-"5 MPa have been investigated. In order to limit the maximum temperature of the concrete walls to 80 deg. C it was necessary to add thermal insulation layers to the hot Lithium loop surfaces and a conceptual system of two cooling layers in different depths of the concrete walls.

2007-10-01

285

Inelastic excitation in the collisions of relativistic heavy ions  

International Nuclear Information System (INIS)

The penumbra of the profile function describing the nuclear collisions of relativistic heavy ions is related to the cross section for their producing a specific target-nucleus #gamma#-ray, sigmasub(#gamma#). The analysis assumes that the diffuse-edge diffraction model suffices to calculate the inelastic cross sections to the particle-stable states of the target nucleus. When the deformation lengths, deltasub(L) = #beta#sub(L)R, characterizing all important excitations are available from other experiments and the #gamma#-branching of these states is also known, the only unknown quantity determining sigmasub(#gamma#) is found to be the ratio of the diffuseness parameter of the profile function, d, to its radius, R. The most reliably determined values of d/R, for the target "4"0Ca, imply a rather wide penumbra, consistent with microscopic calculations. (orig.).

286

Improvement of tracking performance using prediction-based algorithms for a maneuvering target  

British Library Electronic Table of Contents (United Kingdom)

This paper presents a study involving prediction of a complicated maneuvering target, with the aim of improving the tracking performance of a fire control system (FCS). In this study, we predict the position of a complicated maneuvering target 5 s in advance using the information up to the current time. Because of the large error caused by the complicated maneuvers and the long prediction time interval, the mechanical system of the fire control system will take a heavy load. In order to cope with this problem, several approaches to decreasing the prediction error have been proposed including the prediction algorithms based on the multiple model(MM) filter, interacting multiple model (IMM) filter, and variable dimension with input estimation (VDIE) filter. Finally, comparative simulation re...

2011-01-01

287

Hyperspectral remote sensing for mineral exploration in Pulang, Yunnan Province, China  

British Library Electronic Table of Contents (United Kingdom)

The launch of the first spaceborne hyperspectral instrument, Hyperion, in 2000 has provoked further research into its capabilities with regard to mineral exploration. Our study in the remote, mountainous region of Pulang, China employed a two-step progressive approach, first to locate target areas characterized by hydrothermal mineral alteration, using the Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER), and secondly, to attempt detailed mineral mapping using Hyperion. The preliminary target detection involved principal components and broad-band spectral analysis and led to the detection of two target areas characterized by argillic alteration, iron-oxide- and sulphate-bearing minerals. A focused hyperspectral study followed using Spectral Angle Mapper (SAM) and Mixt...

2011-01-01

288

Detached divertor plasmas in JET  

Energy Technology Data Exchange (ETDEWEB)

In simulations with high radiated power fractions, it is possible to produce the drop in ion current to the divertor targets typical of detached plasmas. Despite the fact that these experiments are performed on beryllium target tiles, radiation from deuterium and beryllium cannot account for the measured power losses. The neutral deuterium levels in the SOL in these plasmas are higher than the model predicts. This may be due to leakage from the divertor or to additional wall sources related to the non-steady nature of these plasmas. In contrast, a surprisingly high level of carbon is present in these discharges; higher even than would be predicted are the divertor target tiles pure carbon. This level may well be large enough to produce the measured radiation. (authors). 6 refs., 2 figs., 1 tab.

1994-07-01

289

Analysis of neutron emission spectra for 30-50 MeV #alpha#-particle induced reactions in thick targets  

International Nuclear Information System (INIS)

Comparisons of calculated neutron yield distributions from #alpha#-particle induced reactions on thick targets are made with measured data to analyze the initial reaction process in the framework of the exciton (hybrid) model code ALICE91 (M. Blann, Lawrence Livermore National Laboratory Report UCID 19614, 1982). We have considered two reaction mechanisms: dissolution of the #alpha# in the nuclear field, and preequilibrium processes initiated by #alpha#-nucleon collisions. Both these processes seem to contribute to the emitted neutron spectra in varying proportions depending on the incident #alpha# energy and possibly on the target nucleus. Contributions from other processes appear to be non-negligible.

2003-06-01

290

A combined numerical and theoretical study on the penetration of a jacketed rod into semi-infinite targets  

British Library Electronic Table of Contents (United Kingdom)

A combined numerical and theoretical study is conducted herein on the penetration of semi-infinite targets by jacketed rods with different r"j"0/r"c"0 ratios where r"j"0 and r"c"0 are the radii of the jacket and the core, respectively. The numerical results show that for smaller r"j"0/r"c"0 ratios the u-v relationship changes only a little compared to that of unitary long rod penetrator of the same core material, hence, the u-v relationship of unitary (homogeneous) long rod penetration is also applicable for jacketed rod penetration. Model for cratering in semi-infinite targets by jacketed rods is then suggested by using the laws of conversation of mass, momentum and energy, together with the u-v relationship of unitary (homogeneous) long rod penetration and an analytical model for predict...

2011-01-01

291

What's new in target volume definition for radiologists in ICRU Report 71? How can the ICRU volume definitions be integrated in clinical practice?  

UK PubMed Central (United Kingdom)

AbstractThe optimal definition of the size, shape and location of gross tumour volume is one of the most important steps in the planning of radiation therapy, and necessitates a proper...Full Text Available

292

Variable domain I of nematode CLEs directs post-translational targeting of CLE peptides to the extracellular space  

UK PubMed Central (United Kingdom)

Effector proteins expressed in the esophageal gland cells of cyst nematodes are delivered into plant cells through a hollow, protrusible stylet. Although evidence indicates that effector proteins function...Full Text Available

2010-12-01

293

Update on the Role of Substantia Nigra Pars Reticulata in the Regulation of Seizures  

UK PubMed Central (United Kingdom)

The substantia nigra pars reticulata (SNR) represents an endogenous seizure suppressing system, which may be targeted to develop treatments for generalized or multifocal epilepsies. This review summarizes...Full Text Available

2006-05-01

294

Three-dimensional simulation study of compact toroid plasmoid injection into magnetized plasmas  

Energy Technology Data Exchange (ETDEWEB)

Three-dimensional dynamics of a compact toroid (CT) plasmoid, which is injected into a magnetized target plasma region is investigated by using magnetohydrodynamic (MHD) numerical simulations. It is found that the process of the CT penetration into this region is much more complicated than what has been analyzed so far by using a conducting sphere (CS) model. The injected CT suffers from a tilting instability, which grows with the similar time scale as the CT penetration. The instability is accompanied by magnetic reconnection between the CT magnetic field and the target magnetic field, which disrupts the magnetic configuration of the CT. Magnetic reconnection plays a role to supply the high density plasma initially confined in the CT magnetic field into the target region. Also, the penetration depth of the CT high density plasma is examined. It is shown to be shorter than that estimated from the CS model. The CT high ...

1999-04-01

295

The sensitivity of real-time PCR amplification targeting invasive Salmonella serovars in biological specimens  

UK PubMed Central (United Kingdom)

BackgroundPCR amplification for the detection of pathogens in biological material is generally considered a rapid and informative diagnostic technique. Invasive Salmonella...Full Text Available

296

The selective hypoxia inducible factor-1 inhibitor PX-478 provides in vivo radiosensitization through tumor stromal effects  

UK PubMed Central (United Kingdom)

Hypoxia inducible factor-1 (HIF-1) promotes tumor cell adaptation to microenvironmental stress. HIF-1 is up-regulated in irradiated tumors and serves as a promising target for radiosensitization....Full Text Available

2009-04-01

297

The selection and definition of targeted work-related conditions for surveillance under SENSOR.  

UK PubMed Central (United Kingdom)

Lists of reportable conditions and case definitions are important tools for epidemiologic surveillance. As part of an initiative to encourage occupational disease surveillance systems linked to intervention...Full Text Available

1989-12-01

298

The prospects for polarized target materials with pure carbon background  

Science.gov (United States)

None of the materials presently in common use for polarized proton targets has a pure carbon nuclear background. The alcohols and diols contain some oxygen, and the ammonia and amine-based materials contain nitrogen and/or other noncarbon species. In the latter cases the noncarbon nuclei are measurably polarized as a concomitant of the process used to polarize the hydrogen nuclei. The relative simplicity of a pure carbon background would be advantageous for most types of scattering experiments and perhaps crucial for some. In addition to simplifying the kinematics of background events, pure carbon is relatively easy to prepare as a dummy'' target for background subtraction. Also, in such a target material, [sup 13]C-enrichment would yield a clean polarized [sup 13]C material. In this note I explore the possibilities for such materials, touching upon only what I consider to be the ...

1992-10-06

299

The implication of Sir2 in replicative aging and senescence in Saccharomyces cerevisiae  

UK PubMed Central (United Kingdom)

The target of rapamycin (TOR) pathway regulates cell growth and aging in various organisms. In Saccharomyces cerevisiae, silent information regulator 2 (Sir2) modulates cellular senescence. Moreover,...Full Text Available

300

The anxious wait: assessing the impact of patient accessible EHRs for breast cancer patients  

UK PubMed Central (United Kingdom)

BackgroundPersonal health records (PHRs) provide patients with access to personal health information (PHI) and targeted education. The use of PHRs has the potential to improve a...Full Text Available

301

The Spectrum of Monogenic Autoinflammatory Syndromes: Understanding Disease Mechanisms and Use of Targeted Therapies  

UK PubMed Central (United Kingdom)

Monogenic autoinflammatory diseases encompass a distinct and growing clinical entity of multisystem inflammatory diseases with known genetic defects in the innate immune system. The diseases...Full Text Available

2008-07-01

302

The Regulation of Aging and Longevity  

UK PubMed Central (United Kingdom)

p53 plays a critical role in tumor suppression. As a transcription factor, in response to stress signals, p53 regulates its target genes and initiates stress responses, including cell cycle arrest,...Full Text Available

2011-04-01

303

The Magdalena Ridge Observatory 2.4 m Telescope  

Science.gov (United States)

EOS Technologies has been commissioned to design and build a unique 2.4m astronomical telescope for the Magdalena Ridge Observatory. This telescope utilizes a high quality primary mirror and cell from a now decommissioned military application. This paper describes the project and gives an overview of the telescope design. The Magdalena Ridge Observatory (MRO) 2.4 meter telescope will be primarily utilized to observe, track, and characterize solar system astronomical targets, Earth satellites, space vehicles, and terrestrial military targets. The telescope's rapid tracking (slew rates are 10o/sec) will allow it to move to any target and acquire data within one minute of receipt of notice. In this way, the telescope will be used to capitalize on targets of opportunity that occur in asteroid studies (e.g., Near Earth Objects) and in astrophysics, such as gamma ray bursts and other transient phenomena. ...

2006-07-01

304

The Burden of Common Infectious Disease Syndromes at the Clinic and Household Level from Population-Based Surveillance in Rural and Urban Kenya  

UK PubMed Central (United Kingdom)

BackgroundCharacterizing infectious disease burden in Africa is important for prioritizing and targeting limited resources for curative and preventive services and monitoring the...Full Text Available

305

Targeting the p53 Pathway in Ewing Sarcoma  

UK PubMed Central (United Kingdom)

The p53 tumour suppressor plays a pivotal role in the prevention of oncogenic transformation. Cancers frequently evade the potent antitumour surveillance mechanisms of p53 through mutation of the TP53...Full Text Available

2011-01-01

306

Targeting the Pentose Phosphate Pathway in Syndrome X-related Cardiovascular Complications  

UK PubMed Central (United Kingdom)

Syndrome X is a combination or co-occurrence of several known cardiovascular risk factors (including central obesity, dyslipidemias, fatty liver disease, hyperinsulinemia, insulin resistance,...Full Text Available

2010-05-01

307

Targeted plasmid integration into the human genome by an engineered zinc-finger recombinase  

UK PubMed Central (United Kingdom)

The development of new methods for gene addition to mammalian genomes is necessary to overcome the limitations of conventional genetic engineering strategies. Although a variety of DNA-modifying enzymes...Full Text Available

2011-09-01

308

Targeted gene transfection from microbubbles into vascular smooth muscle cells using focused, ultrasound-mediated delivery  

UK PubMed Central (United Kingdom)

We investigate a method for gene delivery to vascular smooth muscle cells using ultrasound triggered delivery of plasmid DNA from electrostatically coupled cationic microbubbles. Microbubbles...Full Text Available

2010-09-01

309

Target organs and systems: methodologies to assess immune system function.  

UK PubMed Central (United Kingdom)

Immunotoxicity encompasses both reduced and heightened immune function. Diverse chemicals can impair functioning of the immune system. Both monographs and books have been devoted to detailed descriptions...Full Text Available

1998-04-01

310

Systematics of average radiative width of heavy nuclides  

Energy Technology Data Exchange (ETDEWEB)

Systematics of neutron capture radiative width were studied in the target element range from Th to Cm. Reduced radiative widths were analyzed with a simple radiative width formula based on E1 transition. Average radiative width is presented with the standard deviation of 15%. (author)

1999-03-01

311

Synthetic substrates for measuring activity of autophagy proteases  

UK PubMed Central (United Kingdom)

Atg4 cysteine proteases (autophagins) play crucial roles in autophagy by proteolytic activation of Atg8 paralogs for targeting to autophagic vesicles by lipid conjugation, as well as in subsequent deconjugation...Full Text Available

2010-10-01

312

Synthesis and characterization of a biotinylated organophosphorus ester for detection and affinity purification of a brain serine esterase: neuropathy target esterase.  

UK PubMed Central (United Kingdom)

We have synthesized a novel stable precursor, saligenin phosphorotrichloridate, which, on reaction with N-monobiotinyldiamines, generates a series of biotinylated covalent inhibitors of serine esterases....Full Text Available

1994-07-15

313

Structure of Natural Killer Cell Receptor KLRG1 Bound to E-Cadherin Reveals Basis for MHC-Independent Missing Self Recognition  

UK PubMed Central (United Kingdom)

SUMMARYThe cytolytic activity of natural killer (NK) cells is regulated by inhibitory receptors that detect the absence of self molecules on target cells. Structural studies of...Full Text Available

2009-07-17

314

Stem cell niches and other factors that influence the sensitivity of bone marrow to radiation-induced bone cancer and leukaemia in children and adults  

UK PubMed Central (United Kingdom)

Purpose: This paper reviews and reassesses the internationally accepted niches or ‘targets’ in bone marrow that are sensitive to the induction of leukaemia and primary...Full Text Available

2011-04-01

315

Species-specific microRNA roles elucidated following astrocyte activation  

UK PubMed Central (United Kingdom)

MicroRNAs (miRNAs) are short non-coding RNAs that play a central role in regulation of gene expression by binding to target genes. Many miRNAs were associated with the function of the central nervous...Full Text Available

2011-05-01

316

Soluble Epoxide Hydrolase as a Therapeutic Target for Cardiovascular Diseases  

UK PubMed Central (United Kingdom)

PrefaceCardiovascular effects of epoxyeicosatrienoic acids (EETs) include vasodilation, vascular smooth muscle cell anti-migratory actions, and anti-inflammatory actions. These...Full Text Available

2009-10-01

317

Soluble Epoxide Hydrolase Inhibition: Targeting Multiple Mechanisms of Ischemic Brain Injury with a Single Agent  

UK PubMed Central (United Kingdom)

SummarySoluble epoxide hydrolase (sEH) is a key enzyme in the metabolic conversion and degradation of P450 eicosanoids called epoxyeicosatrienoic acids (EETs). Genetic variations...Full Text Available

2009-03-01

318

Roles of lead-binding proteins in mediating lead bioavailability.  

UK PubMed Central (United Kingdom)

The intracellular bioavailability of lead (Pb) at low dosage levels in major target organs such as the kidney and brain appears to be largely determined by complexation with a group of low molecular...Full Text Available

1998-12-01

319

Role of nitroso radicals as drug targets in circulatory shock  

UK PubMed Central (United Kingdom)

A vast amount of circumstantial evidence implicates oxygen-derived free radicals (especially, superoxide and hydroxyl radical) and high-energy oxidants [such as peroxynitrite (OONO)]...Full Text Available

2009-06-01

320

Regional Convection-Enhanced Delivery of Gadolinium-labeled Albumin in the Rat Hippocampus In Vivo  

UK PubMed Central (United Kingdom)

Convection-enhanced delivery (CED) has emerged as a promising method of targeted drug-delivery for treating central nervous system (CNS) disorders, but the influence of brain structure on infusate...Full Text Available

2010-03-15

321

Rare Homologous Gene Targeting in Histoplasma capsulatum: Disruption of the URA5Hc Gene by Allelic Replacement  

UK PubMed Central (United Kingdom)

URA5 genes encode orotidine-5′-monophosphate pyrophosphorylase (OMPpase), an enzyme involved in pyrimidine biosynthesis. We cloned the Histoplasma capsulatum URA5...Full Text Available

1998-10-01

322

Rapid, sensitive detection of Mycoplasma pneumoniae in simulated clinical specimens by DNA amplification.  

UK PubMed Central (United Kingdom)

The polymerase chain reaction (PCR) was investigated as a means of diagnosing Mycoplasma pneumoniae infections. The target DNA sequence was a 375-bp segment of the P1 virulence protein. This DNA segment...Full Text Available

1992-12-01

323

Rapamycin inhibits trypanosome cell growth by preventing TOR complex 2 formation  

UK PubMed Central (United Kingdom)

Target of rapamycin (TOR) kinases control cell growth through two functionally distinct multiprotein complexes. TOR complex 1 (TORC1) controls temporal cell growth and is sensitive to rapamycin, whereas...Full Text Available

2008-09-23

324

ROCK DEFORMATION. Final Progress Report  

Energy Technology Data Exchange (ETDEWEB)

The Gordon Research Conference (GRC) on ROCK DEFORMATION was held at II Ciocco from 5/19/02 thru 5/24/02. Emphasis was placed on current unpublished research and discussion of the future target areas in this field.

2002-05-24

325

RNA:DNA Ratio and Other Nucleic Acid Derived Indices in Marine Ecology  

UK PubMed Central (United Kingdom)

Some of most used indicators in marine ecology are nucleic acid-derived indices. They can be divided by target levels in three groups: 1) at the organism level as ecophysiologic indicators, indicators...Full Text Available

326

Putative Biomarkers and Targets of Estrogen Receptor Negative Human Breast Cancer  

UK PubMed Central (United Kingdom)

Breast cancer is a progressive and potentially fatal disease that affects women of all ages. Like all progressive diseases, early and reliable diagnosis is the key for successful treatment and annihilation....Full Text Available

327

Protein Targets of Reactive Metabolites of Thiobenzamide in Rat Liver In Vivo  

UK PubMed Central (United Kingdom)

Thiobenzamide (TB) is a potent hepatotoxin in rats, causing dose-dependent hyperbilirubinemia, steatosis, and centrolobular necrosis. These effects arise subsequent to and appear to result from...Full Text Available

2008-07-01

328

Protein Damage by Reactive Electrophiles: Targets and Consequences  

UK PubMed Central (United Kingdom)

It has been sixty years since the Millers first described the covalent binding of carcinogens to tissue proteins. Protein covalent binding was gradually overshadowed by the emergence of DNA...Full Text Available

2008-01-01

329

Prolonged signaling at the parathyroid hormone receptor by peptide ligands targeted to a specific receptor conformation  

UK PubMed Central (United Kingdom)

The parathyroid hormone receptor (PTHR) is a class B G protein-coupled receptor that plays critical roles in bone and mineral ion metabolism. Ligand binding to the PTHR involves interactions to both...Full Text Available

2008-10-28

330

Predictive and prognostic markers for epidermal growth factor receptor inhibitor therapy in non-small cell lung cancer  

UK PubMed Central (United Kingdom)

Epidermal growth factor receptor (EGFR) related therapies – mainly tyrosine kinase inhibitors (TKIs) such as erlotinib and gefitinib, but also monoclonal antibodies targeting EGFR, for example,...Full Text Available

2009-11-01

331

Potential of mTOR inhibitors for the treatment of subependymal giant cell astrocytomas in tuberous sclerosis complex  

UK PubMed Central (United Kingdom)

Rapamycin inhibits the mTOR (target of rapamycin) pathway and extends lifespan in multiple species. The tuberous sclerosis complex (TSC) protein is a negative regulator of mTOR. In humans, loss of the...Full Text Available

332

Potassium channels as a potential therapeutic target for trigeminal neuropathic and inflammatory pain  

UK PubMed Central (United Kingdom)

Previous studies in several different trigeminal nerve injury/inflammation models indicated that the hyperexcitability of primary afferent neurons contributes to the pain pathway underlying mechanical...Full Text Available

333

Pion-induced fission  

Energy Technology Data Exchange (ETDEWEB)

The A(..pi../sup +/,/sup 3/He)B reaction near threshold is studied in a model where the pion is absorbed by an /sup 4/He constituent of the target nucleus. The predictions of this model using harmonic oscillator cluster wave functions agree semi-quantitatively with the experimental data on the inverse reaction.

1982-03-10

334

Paradoxical function for the receptor for advanced glycation end products in mouse models of pulmonary fibrosis  

UK PubMed Central (United Kingdom)

Idiopathic pulmonary fibrosis (IPF) is a progressive disease with poor survival. The identification of therapeutic targets is essential to improving outcomes. Previous studies found that expression...Full Text Available

2011-03-31

335

Pancreatic cancer: molecular pathogenesis and new therapeutic targets  

UK PubMed Central (United Kingdom)

Patients with pancreatic cancer normally present with advanced disease that is lethal and notoriously difficult to treat. Survival has not improved dramatically, despite routine use of chemotherapy...Full Text Available

2009-07-01

336

PCR-based method for targeting 16S-23S rRNA intergenic spacer regions among Vibrio species  

UK PubMed Central (United Kingdom)

BackgroundThe genus Vibrio is a diverse group of Gram-negative bacteria comprised of 74 species. Furthermore, the genus has and is expected to continue expanding...Full Text Available

337

Optimization of isotope production by cross section determination  

International Nuclear Information System (INIS)

In order to optimize the production of "2"0"1Tl and "6"7Ga using the (p, xn) reactions on enriched "2"0"3Tl and "6"8Zn targets we established a new set of cross section curves for the most relevant reactions. Target stacks made of up to 15 thin (50 #mu#m) natural Tl or Zn foils interleaved with brass degradation foils were irradiated with incident proton energies from 42 to 10 MeV in overlapping experiments. Yields for "2"0"0","2"0"1","2"0"2"m","2"0"3","2"0"4"mPB and "6"6","6"7","6"8Ga were computed from measured #gamma# emission rates. Where possible, cross section curves for the nuclear reactions involved were computed. Thick target yields and contamination ratios for enriched targets were derived and show good agreement with results from actual production runs. (orig.).

338

Optimal bone strength and mineralization requires the type 2 iodothyronine deiodinase in osteoblasts  

UK PubMed Central (United Kingdom)

Hypothyroidism and thyrotoxicosis are each associated with an increased risk of fracture. Although thyroxine (T4) is the predominant circulating thyroid hormone, target cell responses are determined...Full Text Available

2010-04-20

339

Nucleoside Drugs Induce Cellular Differentiation by Caspase-Dependent Degradation of Stem Cell Factors  

UK PubMed Central (United Kingdom)

BackgroundStem cell characteristics are an important feature of human cancer cells and play a major role in the therapy resistance of tumours. Strategies to target cancer stem cells...Full Text Available

340

Nuclear Targeting of Methyl-Recycling Enzymes in Arabidopsis thaliana Is Mediated by Specific Protein Interactions.  

Science.gov (United States)

Numerous transmethylation reactions are required for normal plant growth and development. S-adenosylhomocysteine hydrolase (SAHH) and adenosine kinase (ADK) act coordinately to recycle the by-product of these reactions, S-adenosylhomocysteine (SAH) that would otherwise competitively inhibit methyltransferase (MT) activities. Here, we report on investigations to understand how the SAH produced in the nucleus is metabolized by SAHH and ADK. Localization analyses using green fluorescent fusion proteins demonstrated that both enzymes are capable of localizing to the cytoplasm and the nucleus, although no obvious nuclear localization signal was found in their sequences. Deletion analysis revealed that a 41-amino-acid segment of SAHH (Gly(150)-Lys(190)) is required for nuclear targeting of this enzyme. This segment is surface exposed, shows unique sequence conservation patterns in plant SAHHs, and possesses additional features of protein-protein interaction motifs. ADK ...

2011-10-01

341

Noradrenergic ?1 Receptors as a Novel Target for the Treatment of Nicotine Addiction  

UK PubMed Central (United Kingdom)

Nicotine is the main psychoactive ingredient in tobacco and its rewarding effects are considered primarily responsible for persistent tobacco smoking and relapse. Although dopamine has been extensively...Full Text Available

2010-07-01

342

Nano to micro delivery systems: targeting angiogenesis in brain tumors  

UK PubMed Central (United Kingdom)

Treating brain tumors using inhibitors of angiogenesis is extensively researched and tested in clinical trials. Although anti-angiogenic treatment holds a great potential for treating primary and secondary...Full Text Available

343

Multiple Functions of the 37/67-kd Laminin Receptor Make It a Suitable Target for Novel Cancer Gene Therapy  

UK PubMed Central (United Kingdom)

The 37/67-kd laminin receptor, LAMR, is a multifunctional protein that associates with the 40S ribosomal subunit and also localizes to the cell membrane to interact with the extracellular matrix. LAMR...Full Text Available

2010-01-01

344

Motion compensation with a scanned ion beam: a technical feasibility study  

UK PubMed Central (United Kingdom)

BackgroundIntrafractional motion results in local over- and under-dosage in particle therapy with a scanned beam. Scanned beam delivery offers the possibility to compensate target...Full Text Available

345

Molecular dynamics of a ?B DNA element: base flipping via cross-strand intercalative stacking in a microsecond-scale simulation  

UK PubMed Central (United Kingdom)

The sequence-dependent structural variability and conformational dynamics of DNA play pivotal roles in many biological milieus, such as in the site-specific binding of transcription factors to target...Full Text Available

2008-09-01

346

MicroRNAs and small interfering RNAs can inhibit mRNA expression by similar mechanisms  

UK PubMed Central (United Kingdom)

MicroRNAs (miRNAs) are endogenously encoded small noncoding RNAs, derived by processing of short RNA hairpins, that can inhibit the translation of mRNAs bearing partially complementary target sequences....Full Text Available

2003-08-19

347

Mechanisms of confluence-dependent expression of CD26 in colon cancer cell lines  

UK PubMed Central (United Kingdom)

BackgroundCD26 (dipeptidyl peptidase IV, DPPIV) is a 110 kDa surface glycoprotein expressed in most normal tissues, and is a potential novel therapeutic target for selected cancers....Full Text Available

348

Measurements of Spectral Characteristics of Swimmer Targets ...  

Science.gov (United States)

... 3.0 Radar Measurements 3-1 3. 1 Spectral Density Measurements 3-2 3. 1. 1 System Calibration 3-3 ... 3. 1 SPECTRAL DENSITY MEASUREMENTS ...

1974-05-01

349

Mass Production of 64Cu with 64Ni(p,n)64Cu Nuclear Reaction and Target Material Recycling  

International Nuclear Information System (INIS)

64Cu (T1/2=12.7h, ?- decay: 40%, ?+ decay: 19%, E.C. decay: 41%) is one of the most useful radioisotope in the nuclear medicine due to its multiple decay mode and the intermediate half-life. Several nuclear reaction, i.e., 64Ni(p,n)64Cu, 68Zn(p,?n)64Cu and 64Ni(d,2n)64Cu have been investigated for production. The highest could be obtained with proton irradiation on the enriched 64Ni target. For mass and routine production, the 64Ni target fabrication using electroplating, the reliable chemical separation of 64Cu from the irradiated 64Ni target and the effective recovery process for the recycling of very expensive enriched material ($20,000/g) and so forth are absolutely necessary to be established. In this work, we report our mass production method of 64Cu with 64Ni and Cyclone-30 accelerator

2009-05-01

350

Mammalian target of rapamycin signaling modulates photic entrainment of the suprachiasmatic circadian clock  

UK PubMed Central (United Kingdom)

Inducible gene expression appears to be an essential event that couples light to entrainment of the master mammalian circadian clock located in the suprachiasmatic nucleus (SCN) of the hypothalamus....Full Text Available

2010-05-05

351

Linking Gene Expression and Functional Network Data in Human Heart Failure  

UK PubMed Central (United Kingdom)

BackgroundGene expression profiling and the analysis of protein-protein interaction (PPI) networks may support the identification of disease bio-markers and potential drug targets....Full Text Available

352

LYN is a mediator of epithelial-mesenchymal transition and target of dasatinib in breast cancer  

UK PubMed Central (United Kingdom)

Epithelial-mesenchymal transition (EMT), a switch of polarized epithelial cells to a migratory, fibroblastoid phenotype, is considered a key process driving tumor cell invasiveness and metastasis....Full Text Available

2010-03-15

353

Kinetic Complexity of the Global Response to Glucocorticoid Receptor Action  

UK PubMed Central (United Kingdom)

We have characterized the kinetic response of gene targets throughout the murine genome to transcriptional modulation by the glucocorticoid receptor (GR). In contrast to a model in which multiple genes...Full Text Available

2009-04-01

354

Key Beliefs for Targeted Interventions to Increase Physical Activity in Children: Analyzing Data from an Extended Version of the Theory of Planned Behaviour  

UK PubMed Central (United Kingdom)

Given the high prevalence of overweight and low levels of physical activity among children, a better understanding of physical activity behaviour is an important step in intervention planning. This...Full Text Available

2010-01-01

355

Intracellular delivery of an antisense?oligonucleotide via endocytosis of a G protein-coupled receptor  

UK PubMed Central (United Kingdom)

Gastrin-releasing peptide receptor (GRPR), a member of the G protein-coupled receptor superfamily, has been utilized for receptor-mediated targeting of imaging and therapeutic agents; here we extend...Full Text Available

2010-10-01

356

Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression  

UK PubMed Central (United Kingdom)

As the result of genetic alterations and tumor hypoxia, many cancer cells avidly take up glucose and generate lactate through lactate dehydrogenase A (LDHA), which is encoded by a target gene of c-Myc...Full Text Available

2010-02-02

357

Increased degradation of MYPT1 contributes to the development of tolerance to nitric oxide in porcine pulmonary artery  

UK PubMed Central (United Kingdom)

Myosin phosphatase target subunit 1 (MYPT1) is the regulatory subunit of myosin light chain phosphatase (MLCP). It plays a critical role in vasodilatation induced by cGMP-elevating agents such as nitric...Full Text Available

2010-07-01

358

In vivo expression and mitochondrial targeting of yeast apoiso-1-cytochrome c fusion proteins.  

UK PubMed Central (United Kingdom)

To define the import pathway for apoiso-1-cytochrome c in vivo, the coding region for bacterial chloramphenicol acetyltransferase (CAT) or yeast copper metallothionein (CuMT) was fused to the carboxy...Full Text Available

1990-11-01

359

In vitro analysis of nuclear mRNA export using molecular beacons for target detection  

UK PubMed Central (United Kingdom)

A detailed molecular characterization of nuclear mRNA export will require an in vitro system, allowing a biochemical reconstitution of transport. To this end, an mRNA export assay has...Full Text Available

2003-06-01

360

Immunochemical Analysis of the Temporal and Tissue-Specific Expression of an Avena sativa Plasma Membrane Determinant 1  

UK PubMed Central (United Kingdom)

An immunoglobulin Mk monoclonal (F8IVE9) antibody raised against oat (Avena sativa cv Garry) root homogenate has been produced and characterized. The predominant target...Full Text Available

1992-01-01

361

Identification of circulating neuropilin-1 and dose-dependent elevation following anti-neuropilin-1 antibody administration  

UK PubMed Central (United Kingdom)

Neuropilin-1 (NRP1) acts as a co-receptor for class 3 semaphorins and vascular endothelial growth factor and is an attractive angiogenesis target for cancer therapy. In addition to the transmembrane...Full Text Available

2009-07-01

362

Identification of Achaete-scute complex-like 1 (ASCL1) target genes and evaluation of DKK1 and TPH1 expression in pancreatic endocrine tumours  

UK PubMed Central (United Kingdom)

BackgroundASCL1 role in pancreatic endocrine tumourigenesis has not been established. Recently it was suggested that ASCL1 negatively controls expression of the...Full Text Available

363

Identification and Characterization of Retinoid-Active Short-Chain Dehydrogenases/Reductases in Drosophila melanogaster  

UK PubMed Central (United Kingdom)

BackgroundIn chordates, retinoid metabolism is an important target of short-chain dehydrogenases/reductases (SDRs). It is not known whether SDRs play a role in retinoid...Full Text Available

2009-10-01

364

INVERTEBRATE FAUNA ASSOCIATED WITH TORPEDOGRASS, PANICUM REPENS (CYPERALES: POACEAE), IN LAKE OKEECHOBEE, FLORIDA, AND ...  

Science.gov (United States)

... 154. By way of comparison, the aquatic weed Hygrophila polysperma (Roxb.) T. Anderson, a potential target for biological ... L. Sutton. 2000. Is the aquatic weed hygrophila, Hygrophila polysperma (Polemon...

365

Human Immunodeficiency Virus-1 Inhibition of Immunoamphisomes in Dendritic Cells Impairs Early Innate and Adaptive Immune Responses  

UK PubMed Central (United Kingdom)

SUMMARYDendritic cells (DCs) in mucosal surfaces are early targets for human immunodeficiency virus-1 (HIV-1). DCs mount rapid and robust immune responses upon pathogen encounter....Full Text Available

2010-05-28

366

Heat Stress Enhances the Accumulation of Polyadenylated Mitochondrial Transcripts in Arabidopsis thaliana  

UK PubMed Central (United Kingdom)

BackgroundPolyadenylation of RNA has a decisive influence on RNA stability. Depending on the organisms or subcellular compartment, it either enhances transcript stability or targets...Full Text Available

367

Health and function of participants in the Long Life Family Study: A comparison with other cohorts  

UK PubMed Central (United Kingdom)

Individuals from families recruited for the Long Life Family Study (LLFS) (n= 4559) were examined and compared to individuals from other cohorts to determine whether the recruitment targeting longevity...Full Text Available

368

Hair Mercury Negatively Correlates with Calcium Pump Activity in Human Term Newborns and Their Mothers at Delivery  

UK PubMed Central (United Kingdom)

BackgroundCalcium homeostasis is a known target of several environmental toxicants including lead and mercury.ObjectiveOur goal was to determine...Full Text Available

2008-02-01

369

Gyrase B Inhibitor Impairs HIV-1 Replication by Targeting Hsp90 and the Capsid Protein*  

UK PubMed Central (United Kingdom)

Chemical genetics is an emerging approach to investigate the biology of host-pathogen interactions. We screened several inhibitors of ATP-dependent DNA motors and detected the gyrase B inhibitor coumermycin...Full Text Available

2010-12-10

370

Goldin says NASA must reach streamlining targets - Johnson Space ...  

Science.gov (United States)

Jan 20, 1995 ... Jenn-Air dowedraft cooktop, staintess steel, coil. $75; telephone ans mach, $25. Eric, x31917. $295; President & First Lady premier plus ...

371

Glutamatergic regulation of ghrelin-induced activation of the mesolimbic dopamine system  

UK PubMed Central (United Kingdom)

Recently, we demonstrated that the central ghrelin signalling system, involving the ghrelin receptor (GHS-R1A), is important for alcohol reinforcement. Ghrelin targets a key mesolimbic circuit involved...Full Text Available

2011-01-01

372

Genetic Diversity in Blastomyces dermatitidis: Implications for PCR Detection in Clinical and Environmental Samples  

UK PubMed Central (United Kingdom)

SummaryBlastomycosis is a serious and potentially fatal infection by the thermally dimorphic fungus Blastomyces dermatitidis. PCR assays targeting the BAD-1 virulence...Full Text Available

2010-03-01

373

Gene expression analysis of interferon ? in laser capture microdissected cervical epithelium  

UK PubMed Central (United Kingdom)

Optimal sample handling techniques for tissue preparation and storage, RNA extraction and quantification, and target gene detection are crucial for reliable gene expression analysis. Methods...Full Text Available

2008-10-01

374

Fyn Is a Novel Target of (?)-Epigallocatechin Gallate in the Inhibition of JB6 Cl41 Cell Transformation  

UK PubMed Central (United Kingdom)

The cancer preventive action of (−)-epigallocatechin gallate (EGCG), found in green tea, is strongly supported by epidemiology and laboratory research data. However, the mechanism by...Full Text Available

2008-03-01

375

Forecasting changes in amphibian biodiversity: aiming at a moving target  

UK PubMed Central (United Kingdom)

Amphibian population declines and sudden species' extinctions began to be noted at the beginning of the 1980s. Understanding the causes of the losses is hampered by our poor knowledge of the amphibian...Full Text Available

2005-02-28

376

Food Advertising and Marketing Directed at Children and Adolescents in the US  

UK PubMed Central (United Kingdom)

In recent years, the food and beverage industry in the US has viewed children and adolescents as a major market force. As a result, children and adolescents are now the target of intense and specialized...Full Text Available

377

First line targeted therapies in breast cancer: focus on bevacizumab  

UK PubMed Central (United Kingdom)

The heterogeneity of metastatic breast cancer mandates the need to select therapies taking into account tumor and patient characteristics. Chemotherapy is indicated in the palliative setting especially...Full Text Available

2007-03-01

378

Excitation functions for proton-induced reactions on natural hafnium: Production of {sup 177}Lu for medical use  

Energy Technology Data Exchange (ETDEWEB)

There is an increasing interest in using radioisotopes of rare earth elements for internal radiotherapy and for imaging in nuclear medicine. {sup 177}Lu is one of the promising radionuclides. This article reports on the first measurements of the excitation function for the production of {sup 177}Lu with proton-beam energies up to 17 MeV on natural hafnium targets. The experimental cross sections for the reaction {sup nat}Hf(p,x){sup 177}Lu were obtained by the activation of a stacked-foil target and subsequent gamma spectrometry. Theoretical cross sections were calculated up to 35 MeV with the EMPIRE nuclear reaction model code. The measured and calculated cross sections were used for deriving the thick-target yields and for estimating the production of other nuclides than {sup 177}Lu. Measured production cross sections of {sup 175,176,177,178}Ta on the same target are also presented.

2009-11-15

379

Excitation functions for proton-induced reactions on natural hafnium: Production of "1"7"7Lu for medical use  

International Nuclear Information System (INIS)

There is an increasing interest in using radioisotopes of rare earth elements for internal radiotherapy and for imaging in nuclear medicine. "1"7"7Lu is one of the promising radionuclides. This article reports on the first measurements of the excitation function for the production of "1"7"7Lu with proton-beam energies up to 17 MeV on natural hafnium targets. The experimental cross sections for the reaction "n"a"tHf(p,x)"1"7"7Lu were obtained by the activation of a stacked-foil target and subsequent gamma spectrometry. Theoretical cross sections were calculated up to 35 MeV with the EMPIRE nuclear reaction model code. The measured and calculated cross sections were used for deriving the thick-target yields and for estimating the production of other nuclides than "1"7"7Lu. Measured production cross sections of "1"7"5","1"7"6","1"7"7","1"7"8Ta on the same target are also presented.

2009-11-01

380

Examining the Phonological Neighborhood Density Effect Using Near Infrared Spectroscopy  

UK PubMed Central (United Kingdom)

Phonological density refers to the number of words that can be generated by replacing a phoneme in a target word with another phoneme in the same position. Although the precise nature of the...Full Text Available

2011-09-01

381

Evidence for divided automatic attention  

Scientific Electronic Library Online (English)

Abstract in english A long-standing debate in the literature is whether attention can form two or more independent spatial foci in addition to the well-known unique spatial focus. There is evidence that voluntary visual attention divides in space. The possibility that this also occurs for automatic visual attention was investigated here. Thirty-six female volunteers were tested. In each trial, a prime stimulus was presented in the left or right visual hemifield. This stimulus was characteriz (more) ed by the blinking of a superior, middle or inferior ring, the blinking of all these rings, or the blinking of the superior and inferior rings. A target stimulus to which the volunteer should respond with the same side hand or a target stimulus to which she should not respond was presented 100 ms later in a primed location, a location between two primed locations or a location in the contralateral hemifield. Reaction time to the positive ...

2008-02-01

382

Evidence for an association between TSH and IGF-1 receptors  

UK PubMed Central (United Kingdom)

TSH receptor (TSHR) plays a central role in regulating thyroid function and is targeted by IgGs in Graves’ disease (GD-IgG). Whether TSHR is involved in the pathogenesis of thyroid associated...Full Text Available

2008-09-15

383

Evaluation of heterogeneity effects for Am reaction rates of the moderated subassemblies  

Energy Technology Data Exchange (ETDEWEB)

The technology of minor actinide recycling in fast reactors has been discussed. In CEA, the feasibility study on Am once-through recycling in Phenix core with the moderated target subassemblies (S/As) has been performed. In this report, the evaluation of the heterogeneity effect on the moderated target S/As is described. It was evaluated by the calculation with the continuous energy Monte-Carlo code, MVP, because the accuracy of the deterministic method for the moderated target S/As is unknown. The reaction rates of four isotopes (Am-241, Am-242, Am242m and Am-243) calculated with the heterogeneous model and the homogeneous one were compared. These four isotopes play the important role in Am incineration. It is seen that the homogeneous model overestimates the reaction rates of Am-241 and Am-243 by 4 - 13%, and underestimates those of Am-242 and Am-242m by 13 - 23%. Further investigation made it clear that the ...

1998-10-01

384

Emulsified Nanoparticles Containing Inactivated Influenza Virus and CpG Oligodeoxynucleotides Critically Influences the Host Immune Responses in Mice  

UK PubMed Central (United Kingdom)

BackgroundAntigen sparing and cross-protective immunity are regarded as crucial in pandemic influenza vaccine development. Both targets can be achieved by adjuvantation strategy...Full Text Available

386

Effects of local texture and grain structure on the sputtering performance of tantalum  

Energy Technology Data Exchange (ETDEWEB)

Tantalum and tantalum-based thin films have gained precedence as the diffusion barrier for copper interconnects used in the latest generation of integrated circuits (ICs). The paper presents insight and observations on the covariance of texture and grain size of wrought tantalum sputtering targets and their influence on sputtering performance. Previous studies involving deposition trials of tantalum targets of varying metallurgical character had demonstrated that both grain size and textural homogeneity is critical for assuring reliable sputtering performance of tantalum. Subsequently, a model had been proposed to prescribe how localized texture bands and orientation clusters in tantalum are effectively resistant to sputter erosion. In this paper, results of atomic force microscopy (AFM) and orientation imaging microscopy (OIM{sup TM}) analyses on the eroded surface of a tantalum sputtering target are presented. Initial ...

2002-07-01

387

Dose Optimization for Long-term rAAV-mediated RNA Interference in the Nigrostriatal Projection Neurons  

UK PubMed Central (United Kingdom)

Short-hairpin RNA (shRNA)–mediated gene knockdown is a powerful tool for targeted gene silencing and an emerging novel therapeutic strategy. Recent publications, however, reported unexpected...Full Text Available

2009-09-01

388

Differential targeting of Tetrahymena ORC to ribosomal DNA and non-rDNA replication origins  

UK PubMed Central (United Kingdom)

The Tetrahymena thermophila origin recognition complex (ORC) contains an integral RNA subunit, 26T RNA, which confers specificity to the amplified ribosomal DNA (rDNA) origin by base...Full Text Available

2009-02-04

389

Development of small-molecule inhibitors of the group I p21-activated kinases, emerging therapeutic targets in cancer  

UK PubMed Central (United Kingdom)

The p21-activated kinases (PAKs), immediate downstream effectors of the small G-proteins of the Rac/cdc42 family, are critical mediators of signaling pathways regulating cellular behaviors and...Full Text Available

2010-09-01

390

Development of fission Mo-99 production technology  

Energy Technology Data Exchange (ETDEWEB)

This R and D project is planed to supply domestic demands of Mo-99 through fission route, and consequently this project will be expected to rise up utilization of HANARO and KAERI's capability for marketing extension into domestic and oversea radiopharmaceutical market. HEU and LEU target types are decided and designed for fission Mo-99 production in domestic. Experimental study of target fabrication technology was performed and developed processing equipments. And conceptual design of target loading/unloading in/from HANARO device are performed. Tracer test of Mo-99 separation and purification process was performed, test results reach to Mo-99 recovery yield above 80% and decontamination factor above 1600. Combined Mo-99 separation and purification process was decided for hot test scheduled from next year, and performance test was performed. Conceptual design for modification of existing hot cell for fission Mo-99 ...

2001-05-01

391

Detection and Identification of Bartonella Species Pathogenic for Humans by PCR Amplification Targeting the Riboflavin Synthase Gene (ribC)  

UK PubMed Central (United Kingdom)

Several Bartonella species have now been implicated as human pathogens. The recovery of these fastidious organisms in the clinical microbiology laboratory remains difficult, and current...Full Text Available

2003-03-01

392

Dengue virus protein recognition by virus-specific murine CD8+ cytotoxic T lymphocytes.  

UK PubMed Central (United Kingdom)

The identification of the protein targets for dengue virus-specific T lymphocytes may be useful for planning the development of subunit vaccines against dengue. We studied the recognition by murine...Full Text Available

1993-02-01

393

Deformation of CHS model  

Energy Technology Data Exchange (ETDEWEB)

We calculate mass spectrum of CHS model deformed by an exactly marginal operator, and find that there are tachyons which are not localized in the target space. Similar deformation is discussed in another CFT which corresponds to separated NS5-branes. A condensation of the tachyons is briefly argued.

2002-10-07

394

DNA base mismatch detection with bulky rhodium intercalators: synthesis and applications  

UK PubMed Central (United Kingdom)

The syntheses and applications of two metallointercalators, Rh(bpy)2(chrysi)3+ and Rh(bpy)2(phzi)3+, that target single base mismatches in DNA are...Full Text Available

2007-01-01

395

Cultural Variation in Vigilance and Precaution Themes.  

Science.gov (United States)

Determine the degree to which different precautionary themes are dominant in various target populations and how these themes are acquired. Assess cultural signals of potential danger: are there different kinds of potential danger in different cultures. Do...

2009-01-01

396

Comparative Analysis of State Fish Consumption Advisories Targeting Sensitive Populations  

UK PubMed Central (United Kingdom)

ObjectiveFish consumption advisories are issued to warn the public of possible toxicological threats from consuming certain fish species. Although developing fetuses and children...Full Text Available

2008-12-01

397

Characterization of the Decision Network for Wing Expansion in Drosophila Using Targeted Expression of the TRPM8 Channel  

UK PubMed Central (United Kingdom)

After emergence, adult flies and other insects select a suitable perch and expand their wings. Wing expansion is governed by the hormone bursicon and can be delayed under adverse environmental...Full Text Available

2009-03-18

398

Characterization of Cytokinin and Adenine Transport in Arabidopsis Cell Cultures1[OA  

UK PubMed Central (United Kingdom)

Cytokinins are distributed through the vascular system and trigger responses of target cells via receptor-mediated signal transduction. Perception and transduction of the signal can occur at the plasma...Full Text Available

2008-12-01

399

Carotenoid Crystal Formation in Arabidopsis and Carrot Roots Caused by Increased Phytoene Synthase Protein Levels  

UK PubMed Central (United Kingdom)

BackgroundAs the first pathway-specific enzyme in carotenoid biosynthesis, phytoene synthase (PSY) is a prime regulatory target. This includes a number of biotechnological approaches...Full Text Available

400

CDC45 and DPB11 are required for processive DNA replication and resistance to DNA topoisomerase I-mediated DNA damage  

UK PubMed Central (United Kingdom)

The antitumor agent camptothecin targets DNA topoisomerase I by reversibly stabilizing a covalent enzyme-DNA intermediate. The subsequent collision of DNA replication forks with these drug-enzyme-DNA...Full Text Available

1999-09-28

401

Beam-forming system for electrostatic accelerator  

International Nuclear Information System (INIS)

A simple beam-forming system is described for the electrostatic accelerator of the Scientific-Research Institute of Nuclear Physics of Moscow State University. The system allows the beam to be focused on targets at various distances for a conductor potential of from 1 to 4 MV and beam currents of up to 35 #mu# A.

1988-01-01

402

Association of Unique, Isolated Treponemes with Bovine Digital Dermatitis Lesions?  

UK PubMed Central (United Kingdom)

This study used a PCR-based approach targeting 16S rRNA gene fragments to determine the occurrence and association of the three bovine digital dermatitis (BDD) treponeme phylogroups within lesions found...Full Text Available

2009-03-01

403

Analysis of target cell susceptibility as a basis for the development of a chemoprotective strategy against benzene-induced hematotoxicities.  

UK PubMed Central (United Kingdom)

A goal of our research is to identify biochemical factors that underlie the susceptibility of bone marrow cell populations to benzene metabolites so as to develop a mechanistically based chemoprotective...Full Text Available

1996-12-01

404

Analysis of illegitimate genomic integration mediated by zinc-finger nucleases: implications for specificity of targeted gene correction  

UK PubMed Central (United Kingdom)

BackgroundFormation of site specific genomic double strand breaks (DSBs), induced by the expression of a pair of engineered zinc-finger nucleases (ZFNs), dramatically increases the...Full Text Available

405

An Eating Disorder Randomized Clinical Trial & Attrition: Profiles & Determinants of Dropout  

UK PubMed Central (United Kingdom)

ObjectiveThis study sought to determine whether differential treatment effects in the targeted mechanisms of change and eating disorder (ED) symptoms are associated...Full Text Available

2011-05-01

406

Alterations in the steroid hormone receptor co-chaperone FKBPL are associated with male infertility: a case-control study  

UK PubMed Central (United Kingdom)

BackgroundMale infertility is a common cause of reproductive failure in humans. In mice, targeted deletions of the genes coding for FKBP6 or FKBP52, members of the FK506 binding...Full Text Available

407

Allosteric Drug Discrimination Is Coupled to Mechanochemical Changes in the Kinesin-5 Motor Core*  

UK PubMed Central (United Kingdom)

Essential in mitosis, the human Kinesin-5 protein is a target for >80 classes of allosteric compounds that bind to a surface-exposed site formed by the L5 loop. Not established is why there...Full Text Available

2010-06-11

408

Activated PPAR? Targets Surface and Intracellular Signals That Inhibit the Proliferation of Lung Carcinoma Cells  

UK PubMed Central (United Kingdom)

Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors belonging to the nuclear hormone receptor superfamily. Their discovery in the 1990s provided insights...Full Text Available

2008-01-01

409

ATG12 Conjugation to ATG3 Regulates Mitochondrial Homeostasis and Cell Death  

UK PubMed Central (United Kingdom)

SUMMARYATG12, an ubiquitin-like modifier required for macroautophagy, has a single known conjugation target, another autophagy regulator called ATG5. Here, we identify ATG3 as...Full Text Available

2010-08-20

410

A pilot application of risk-based methods to establish in-service inspection priorities for nuclear components at Surry Unit 1 Nuclear Power Station  

International Nuclear Information System (INIS)

As part of the Nondestructive Evaluation Reliability Program sponsored by the US Nuclear Regulatory Commission, the Pacific Northwest Laboratory is developing a method that uses risk-based approaches to establish in-service inspection plans for nuclear power plant components. This method uses probabilistic risk assessment (PRA) results and Failure Modes and Effects Analysis (FEMA) techniques to identify and prioritize the most risk-important systems and components for inspection. The Surry Nuclear Power Station Unit 1 was selected for pilot applications of this method. The specific systems addressed in this report are the reactor pressure vessel, the reactor coolant, the low-pressure injection, and the auxiliary feedwater. The results provide a risk-based ranking of components within these systems and relate the target risk to target failure probability values for individual components. These results will be used to guide the development of ...

411

A duplex real-time RT-PCR assay for the detection of California serogroup and Cache Valley viruses  

UK PubMed Central (United Kingdom)

A duplex TaqMan real-time RT-PCR assay was developed for the detection of California (CAL) serogroup viruses and Cache Valley virus (CVV), for use in human surveillance. The targets selected...Full Text Available

2009-10-01

412

A Vasculature-Targeting Regimen of Pre-Operative Docetaxel with or without Bevacizumab for Locally Advanced Breast Cancer  

UK PubMed Central (United Kingdom)

PurposeTaxanes have effects on angiogenesis causing difficulties in separating biologic effects of chemotherapy from those due to angiogenesis inhibitors. This randomized...Full Text Available

2009-05-15

413

A Master Conductor for Aggregate Clearance by Autophagy  

UK PubMed Central (United Kingdom)

Autophagic adapters including p62/SQSTM1 recognize polyubiquitinated autophagic targets such as toxic protein aggregates. Recently reporting in Molecular Cell, Filimonenko et al. provide evidence...Full Text Available

2010-05-18

414

A Bragg curve counter with an internal production target for the measurement of the double-differential cross-section of fragment production induced by neutrons at energies of tens of MeV  

Energy Technology Data Exchange (ETDEWEB)

A Bragg curve counter equipped with an internal production target was developed for the measurements of double-differential cross-sections of fragment production induced by neutrons at energies of tens of MeV. The internal target permitted a large detection solid angle and thus the registration of processes at low production rates. In this specific geometry, the detection solid angle depends on the emission angle and the range of the particle. Therefore the energy, atomic number, and angle of trajectory of the particle have to be taken into account for the determination of the solid angle. For the selection of events with tracks confined within a defined cylindrical volume around the detector axis, a segmented anode was applied. The double-differential cross-sections for neutron-induced production of lithium, beryllium, and boron fragments from a carbon target were measured at 0 deg. for 65 MeV neutrons. The results are in ...

2009-11-11

415

Molybdaen-targets in the Research Centre J``ulich; Erzeugung von Molybdaen fuer die Medizin im FRJ-2 des Forschungszentrums Juelich  

Energy Technology Data Exchange (ETDEWEB)

From autumn this year, the FRJ-2 of the Research Center Juelich will be supplying molybdenum targets to the Institut National des Radioelements in Fleurus, Belgium - which deals in medical radio-isotopes worldwide - thus helping to meet the need for technetium-99, which is used in the medical profession for diagnostic purposes because of its favourable radiological characteristics. Technetium-99 is formed as a result of the radioactive decay of molybdenum-99. For many years now, molybdenum has been produced by the irradiation of uranium in research reactors, so that the initiation of molybdenum production in the FRJ-2 is not especially new. What is unusual, however, are the particular peripheral conditions which result from the combination of the irradiation requirements, a predetermined target design and the technical characteristics of the reactor and which necessitated special solutions. This applies especially to the handling of the ...

1999-06-01

416

The CTOF measurements and Monte Carlo analyses of neutron spectra for backward direction from iron target irradiated by protons with energies from 400 to 1200 MeV  

CERN Document Server

A calorimetric-time-of-flight (CTOF) technique was used for real-time, high-precision measurement of neutron spectrum at the angle of 175 degrees from the initial proton beam direction, which hits a face plane of a cylindrical iron target of 20 cm in diameter and 25 cm thick. A comparison was performed between the neutron spectra predicted by the MARS and the MCNPX code systems and measured by experiments for 0.4-, 0.6-, 0.8-, 1.0-, and 1.2-GeV protons.

2009-01-01

417

Target Diagnostic Instrument-Based Controls Framework for the National Ignition Facility  

Energy Technology Data Exchange (ETDEWEB)

NIF target diagnostics are being developed to observe and measure the extreme physics of targets irradiated by the 192-beam laser. The response time of target materials can be on the order of 100ps--the time it takes light to travel 3 cm--temperatures more than 100 times hotter than the surface of the sun, and pressures that exceed 109 atmospheres. Optical and x-ray diagnostics were developed and fielded to observe and record the results of the first 4-beam experiments at NIF. Hard and soft x-ray spectra were measured, and time-integrated and gated x-ray images of hydrodynamics experiments were recorded. Optical diagnostics recorded backscatter from the target, and VISAR laser velocimetry measurements were taken of laser-shocked target surfaces. Additional diagnostics are being developed and commissioned to observe and diagnose ignition implosions, including various neutron and ...

2007-05-07

418

Simulation of High Power Deposition on Target Materials: Applications in Magnetic, Inertial Fusion, and High Power Plasma Lithography Devices  

International Nuclear Information System (INIS)

High power and particle deposition on target materials are encountered in many applications including magnetic and inertial fusion devices, nuclear and high energy physics applications, and laser and discharge produced plasma devices. Surface and structural damage to plasma-facing components due to the frequent loss of plasma confinement remains a serious problem for the Tokamak reactor concept. The deposited plasma energy causes significant surface erosion, possible structural failure, and frequent plasma contamination.

2006-01-01

419

Real time neutron dosemeter response calculations  

International Nuclear Information System (INIS)

The response of a real time neutron dosemeter using a thin LiF target sandwiched between tow parallel surface barrier semiconductor detectors is studied for different neutron distributions and different angles of incidence. Calculations of the response function defined for a simultaneous detection by the two detectors of the particles emitted when the reaction "6Li(n,t)#alpha# occurs in the target are fulfilled by geometrical considerations of the reaction kinematics and the differential cross section variations. Finally, the efficiency of the studied detection systems is analyzed for dosimetric uses. (author).

1996-04-01

420

Purification of cyclotron-produced {sup 203}Pb for labeling Herceptin  

Energy Technology Data Exchange (ETDEWEB)

A simple and rapid procedure was developed for the purification of cyclotron-produced {sup 203}Pb via the {sup 203}Tl(d,2n) {sup 203}Pb reaction. A Pb(II) selective ion-exchange resin, with commercial name Pb Resin from Eichrom Technologies, Inc., was used to purify {sup 203}Pb from the cyclotron-irradiated Tl target with excellent recovery of the enriched Tl target material. The purified {sup 203}Pb was used to radiolabel the monoclonal antibody Herceptin. The in vitro and in vivo properties of the {sup 203}Pb radioimmunoconjugate were evaluated.

2005-04-01

421

Proton beam monitoring and forming on the target of isotope complex at INR linac  

International Nuclear Information System (INIS)

Special beam extraction channel is used at INR linac for isotope production. It starts from 160 MeV measuring and matching area of accelerator. This choice of beam extraction enables to direct to the target of isotope complex a proton beam of wide energy range up to 160 MeV. It is important for production of different types of nuclides. The measuring results of proton beam behavior in this region are presented. Required beam forming in 160 MeV measuring and matching area of accelerator and in beam extraction channel is discussed.

2010-01-01

422

NuMI proton beam diagnostics and control: achieving 2 megawatt capability  

Energy Technology Data Exchange (ETDEWEB)

The NuMI proton beam at Fermilab currently delivers 120 GeV protons to the neutrino production target with design beam power capability to 400 kW. Upgrade capability to 700 kW is being prepared, with planning toward delivering 2.3 MW beam provided by the Project X accelerator upgrade plan. We report on the system of beam diagnostics and control used in operation of the NuMI beam. Also considered are the steps to provide a robust system for transport and targeting beam of 2 MW and beyond.

2008-10-01

423

Neural solution to the target intercept problems in a gun fire control system  

British Library Electronic Table of Contents (United Kingdom)

Time delay neural networks trained with the backpropagation algorithm are derived for the gun fire control system to correct the miss distance between a target and the projectiles from the gun. Its performance is compared to optimum linear filter based on minimum mean square error [R.E. Kalman, A new approach to linear filtering and prediction problems, J. Basic Eng. 82D (1960) 35-44.]. The structure of the proposed neural controller is described and performance results are shown.

2007-01-01

424

Near-threshold production of {omega}-mesons in the pn{yields}d{omega} reaction  

Energy Technology Data Exchange (ETDEWEB)

The first measurement of the pn{yields}d{omega} total cross-section has been achieved at mean excess energies Q{approx}28 and 57 MeV by using a deuterium cluster-jet target. The momentum of the fast deuteron was measured in the ANKE spectrometer at COSY-Juelich and that of the slow ''spectator'' proton (p{sub sp}) from the pd{yields}p{sub sp}d{omega} reaction in a silicon telescope placed close to the target. The cross-sections lie above those measured for pp{yields}pp{omega} but seem to be below theoretical predictions. (orig.)

2004-09-01

425

Modification of a gas jet transport system for the supression of heavy-mass fission product homologues  

Energy Technology Data Exchange (ETDEWEB)

The uranium target of a gas jet transport system for fission products has been modified by the addition of an aluminum cover foil. The new modification allows fission fragments of low mass to enter a continuous chemistry system while heavier fragments are stopped in the aluminum. The elimination of the heavier homologues allows development of simpler and faster chemical separation procedures. In addition, since the lighter fragments are slowed down by the cover foil a smaller target chamber can be used. This leads to a reduction in system holdup time.

1987-04-15

426

Modification of a gas jet transport system for the supression of heavy-mass fission product homologues  

International Nuclear Information System (INIS)

The uranium target of a gas jet transport system for fission products has been modified by the addition of an aluminum cover foil. The new modification allows fission fragments of low mass to enter a continuous chemistry system while heavier fragments are stopped in the aluminum. The elimination of the heavier homologues allows development of simpler and faster chemical separation procedures. In addition, since the lighter fragments are slowed down by the cover foil a smaller target chamber can be used. This leads to a reduction in system holdup time. (orig.).

427

Mechanical variations of diffused plasma parameters in a double plasma device  

International Nuclear Information System (INIS)

Experimentally it is shown that a movable grounded metallic plate placed inside a multi-dipole magnetic cage can vary the diffused plasma parameters such as density, plasma potential and electron temperature. Plasma is solely produced in the source section of a double plasma device by a dc hot filament discharge and a low-density plasma is produced in the target section by local ionization of neutral gas by the high energetic electrons coming from the source section. A grounded movable stainless steel plate is inserted in the target section of the device. The floating potential of the plate also changes depending on the position of the plate inside the magnetic cage.

2007-06-21

428

Locked nucleic acid (LNA): High affinity targeting of RNA for diagnostics and therapeutics  

DEFF Research Database (Denmark)

Locked nucleic acid (LNA) is a nucleic acid analogue containing one or more LNA nucleotide monomers with a bicyclic furanose unit locked in an RNA mimicking sugar conformation. This conformational restriction results in unprecedented hybridization affinity towards complementary single stranded RNA and thus, makes LNA uniquely suited for mimicking RNA structures and sequence specific targeting of RNA in vitro or in vivo. The focus of this paper is on LNAantisense, LNA-modified siRNA (siLNA), and detection and analysis of microRNAs by LNA-modified oligonucleotide probes.

2005-01-01

429

Inelastic electron--dipole-molecule scattering at sub-milli-electron-volt energies: HF and NH_3  

International Nuclear Information System (INIS)

Studies of destruction of very-high-n (100targets HF and NH_3 are reported. Analysis of the data using the essentially-free-electron model suggests that, for ultralow electron energies (#approx#80 #mu#eV--1.4 meV), the cross section #sigma#(var-epsilon) for rotationally inelastic scattering of electrons by a polar target varies approximately as 1/var-epsilon, where var-epsilon is the electron energy.

430

Experimental research on X-ray spectrum emitted from hot laser-produced aluminium plasma  

International Nuclear Information System (INIS)

The hot uniform aluminium plasma was produced by irradiating thin aluminium dotted foil smoothly with the 9th 0.53 ?m laser on Shenguang II laser facility. The emitted spectrum was measured from the front and tangential direction of the target with two crystal spectrometers, and the quantitative spectrum from the front of the target was obtained. The state of laser- produced plasma was simulated with the radiation hydrodynamics code MULTI-1D, and the emitted spectrum was calculated with the spectrum code of Collision-Radiation model under the simulated plasma state. The experimental spectrum accords with the simulated one. (authors)

2007-12-01

431

Experimental Study of Plasma-Surface Interaction and Material Damage Relevant to ITER Type I Elms  

International Nuclear Information System (INIS)

The paper presents experimental investigations of main features of plasma surface interaction and energy transfer to the material surface in dependence on plasma heat loads. The experiments were performed with QSPA repetitive plasma pulses of the duration of 0.25 ms and the energy density up to 2.5 MJ/m2. Surface morphology of the targets exposed to QSPA plasma screams is analyzed. Relative contribution of the Lorentz force and plasma pressure gradient to the resulting surface profile is discussed. development of cracking on the tungsten surface and swelling of the surface are found to be in strong dependence on initial temperature of the target.

2006-01-01

432

Electron beam therapy in carcinoma of the buccal mucosa  

Energy Technology Data Exchange (ETDEWEB)

Electron beam therapy has often been used for radiation therapy of carcinomas of the buccal mucosa, though side effects, including stomatitis and dermatitis, are known to exist. We experimented using the additional back scatter and transit with the phantom under a lead plate within the irradiation field, in order to better focus the dose on the target volume moreover, we fabricated a mouthpiece fitted with a lead plate shaped to the target volume, and with respect to the influence of the mouthpiece on stomatitis and dermatitis, obtained good clinical results. (author).

1990-10-01

433

Electron beam therapy in carcinoma of the buccal mucosa  

International Nuclear Information System (INIS)

Electron beam therapy has often been used for radiation therapy of carcinomas of the buccal mucosa, though side effects, including stomatitis and dermatitis, are known to exist. We experimented using the additional back scatter and transit with the phantom under a lead plate within the irradiation field, in order to better focus the dose on the target volume moreover, we fabricated a mouthpiece fitted with a lead plate shaped to the target volume, and with respect to the influence of the mouthpiece on stomatitis and dermatitis, obtained good clinical results. (author).

434

Direct dark matter identification with a hybrid detection technique  

CERN Document Server

In the quest to understand the ultimate nature of WIMPs, we propose the use of a hybrid detection technique: cylinders filled with liquefied noble gasses, acting as targets, are immersed inside a tank of Gd-doped ultra-pure water that provides an active and efficient veto against neutrons. The evaluation of the background rejection capabilities and physics potential of this instrument have been carried out through a full GEANT4 simulation, assuming the detector will be located at the Canfranc underground laboratory (in the Spanish Pyrenees). Our results compare very favourably with existing or planned experiments in the field. This technique is scalable and will allow to reach target masses of few tonnes in the next future.

2008-01-01

435

Development of three-dimensional aiming point guidance law  

British Library Electronic Table of Contents (United Kingdom)

A new aiming point guidance (APG) law in 3-dimensional space is derived analytically. The guidance law is capable of guiding the missile (interceptor) to a straight collision course with respect to the target. The missile turning rate command proportional to the error angle between the current missile heading and the predicted aim point is calculated based on the predicted target position. Performance of the APG law is numerically evaluated and compared with the proportional navigation guidance (PNG) law. The result of numerical simulation shows that the APG law is superior to the PNG law in terms of miss distance, time of interception and final stage missile turning rate demand.

2010-01-01

436

Conformal radiation therapy: technical requirements and clinical applications  

International Nuclear Information System (INIS)

Conformal radiation therapy represents a considerable and attractive challenge in oncology. Its aim is mainly to improve local control by increasing the dose with an acceptable rate of complications. This work overviews the world literature on this subject. The technical and theoretical requirements are highlighted. These requirements include a precise definition of the target volume by digital imaging (essentially CT scan), but also clear view of the target volume and the organs at risk, a specific collimation of the beam, 3-D dose calculations, optimization procedures, and a rigid immobilization of the patient with verification of his position. Moreover, the clinical applications of conformal radiation therapy are reviewed and discussed. (authors). 80 refs., 1 tab.

1995-01-01

437

Spectroscopic investigation of the charge dynamics of heavy ions penetrating solid and gaseous targets  

Energy Technology Data Exchange (ETDEWEB)

This thesis presents the study of the slowing down process of fast heavy ions inside matter. In the framework of this research, the influence of the target density on the stopping process is investigated. Experiments on the interaction of {sup 48}Ca{sup 6+}-{sup 48}Ca{sup 10+} and {sup 26}Mg{sup 5+} ion beams with initial energies of 11.4 MeV/u and 5.9 MeV/u with solid and gaseous targets have been carried out. A novel diagnostic method, X-ray spectroscopy of K-shell projectile radiation, is used to determine the ion charge state in relation to its velocity during the penetration of fast heavy ions inside the stopping material. A spatially resolved analysis of the projectile and target radiation in solids is achieved for the first time. The application of low-density silica aerogels as stopping media provided a stretching of the ion stopping length by 20 - 100 times in comparison with solid quartz. The Doppler Effect ...

2007-01-15

438

On the Utility of Antiprotons as Drivers for Inertial Confinement Fusion  

Energy Technology Data Exchange (ETDEWEB)

By contrast to the large mass, complexity and recirculating power of conventional drivers for inertial confinement fusion (ICF), antiproton annihilation offers a specific energy of 90MJ/{micro}g and thus a unique form of energy packaging and delivery. In principle, antiproton drivers could provide a profound reduction in system mass for advanced space propulsion by ICF. We examine the physics underlying the use of antiprotons ({bar p}) to drive various classes of high-yield ICF targets by the methods of volumetric ignition, hotspot ignition and fast ignition. The useable fraction of annihilation deposition energy is determined for both {bar p}-driven ablative compression and {bar p}-driven fast ignition, in association with 0-D and 1-D target burn models. Thereby, we deduce scaling laws for the number of injected antiprotons required per capsule, together with timing and focal spot requirements. The kinetic energy of the injected antiproton ...

2003-10-20

439

Mapping a nucleolar targeting sequence of an RNA binding nucleolar protein, Nop25  

International Nuclear Information System (INIS)

Nop25 is a putative RNA binding nucleolar protein associated with rRNA transcription. The present study was undertaken to determine the mechanism of Nop25 localization in the nucleolus. Deletion experiments of Nop25 amino acid sequence showed Nop25 to contain a nuclear targeting sequence in the N-terminal and a nucleolar targeting sequence in the C-terminal. By expressing derivative peptides from the C-terminal as GFP-fusion proteins in the cells, a lysine and arginine residue-enriched peptide (KRKHPRRAQDSTKKPPSATRTSKTQRRRR) allowed a GFP-fusion protein to be transported and fully retained in the nucleolus. When the peptide was fused with cMyc epitope and expressed in the cells, a cMyc epitope was then detected in the nucleolus. Nop25 did not localize in the nucleolus by deletion of the peptide from Nop25. Furthermore, deletion of a subdomain (KRKHPRRAQ) in the peptide or amino acid substitution of lysine and arginine residues in the subdomain ...

2006-06-10

440

Effects of ion-induced electron emission on magnetron plasma instabilities  

International Nuclear Information System (INIS)

Some magnetron sputtering systems experience rapid oscillations in the current and voltage of the plasma discharge after several hours when equipped with certain targets. These oscillations often lead to the plasma becoming extinguished, a condition known as ''flame-out.'' This article details the study of two 90% W--10% Ti magnetron targets which differed in density. The higher density targets sometimes experienced flame-out after approximately 3 h of sputtering. The less dense material could be sputtered for the entire 15 h life of the target. Scanning electron microscopy pictures and atomic composition depth profiles were obtained using Auger electron spectroscopy. In addition, a Colutron-based ion source with a high vacuum system was used to measure ion-induced secondary electron emission coefficients as a function of energy, ion specie, and gas coverage. Analysis of the sample from the group that ...

441

ELM resolved energy distribution studies in the JET MKII Gas-Box divertor using infra-red thermography  

International Nuclear Information System (INIS)

Using infra-red (IR) thermography, power loads onto the MKII Gas-Box divertor targets have been investigated in Type-I ELMy H-Mode plasmas at JET in medium current discharges (Ip = 2.6 MA and BT = 2.7 T). Heat fluxes are calculated from the measured divertor target tile surface temperatures taking into account the influence of co-deposited surface layers on tile surfaces. This is particularly important when estimating the energy deposition during transient events such as ELMs. Detailed energy balance analysis is used, both from IR and tile embedded thermocouples, to demonstrate an approximately constant ELM-averaged in/out divertor target asymmetry of ?0.55 and to show that the ELM in/out energy deposition ratio ranges from 1 : 1 to 2 : 1. The inter-ELM in/out ratio is close to the ELM-averaged value at low pedestal collisionalities and decreases down to values close to zero when the inner target plasma ...

2007-05-01

442

Design of a closed 4 MW spallation target module with heat removal system for an ADS system  

International Nuclear Information System (INIS)

At the Forschungszentrum Karlsruhe the HGF Strategy Fund project entitled 'Innovative Technology to Reduce Radiotoxicity' is performed which delivers an essential scientific contribution to the application oriented fundamental research for Accelerator Driven Systems (ADS). The addressed topics are in the areas of heavy liquid metal technology, thermalhydraulics and materials / corrosion. An ADS consists of three main components: an proton accelerator, a spallation target and a subcritical blanket. The strategic objective of an ADS is the transmutation of long-lived radioactive waste (plutonium, minor actinides and long-lived fission products) into short-lived isotopes or stable elements, thus closing the fuel cycle. The objective of one task of the HGF Strategy Fund Project is the numerical calculation of a closed spallation target module. In a consequent next step such a spallation target can be experimentally investigated ...

443

Transient enhanced diffusion of dopants in preamorphized Si layers  

Energy Technology Data Exchange (ETDEWEB)

Transient Enhanced Diffusion (TED) of dopants in Si is the consequence of the evolution, upon annealing, of a large supersaturation of Si self-interstitial atoms left after ion bombardment. In the case of amorphizing implants, this supersaturation is located just beneath the c/a interface and evolves through the nucleation and growth of End-Of-Range (EOR) defects. For this reason, the authors discuss here the relation between TED and EOR defects. Modelling of the behavior of these defects upon annealing allows one to understand why and how they affect dopant diffusion. This is possible through the development of the Ostwald ripening theory applied to extrinsic dislocation loops. This theory is shown to be readily able to quantitatively describe the evolution of the defect population (density, size) upon annealing and gives access to the variations of the mean supersaturation of Si self-interstitial atoms between the loops and responsible for TED. This initial ...

1997-11-01

444

Transient enhanced diffusion of dopants in preamorphized Si layers  

International Nuclear Information System (INIS)

Transient Enhanced Diffusion (TED) of dopants in Si is the consequence of the evolution, upon annealing, of a large supersaturation of Si self-interstitial atoms left after ion bombardment. In the case of amorphizing implants, this supersaturation is located just beneath the c/a interface and evolves through the nucleation and growth of End-Of-Range (EOR) defects. For this reason, the authors discuss here the relation between TED and EOR defects. Modelling of the behavior of these defects upon annealing allows one to understand why and how they affect dopant diffusion. This is possible through the development of the Ostwald ripening theory applied to extrinsic dislocation loops. This theory is shown to be readily able to quantitatively describe the evolution of the defect population (density, size) upon annealing and gives access to the variations of the mean supersaturation of Si self-interstitial atoms between the loops and responsible for TED. This initial ...

1996-12-02

445

RESEARCH IN ACTIVATION ANALYSIS. Quarterly Progress Report, April-August 1962  

Science.gov (United States)

The experimental work completed thus far in the areas of rapid radiochemical separations and metastable isomeric states is summarized. Activation analyses were made in samples of ore materials and metals using rapid radiochemical separations to isolate short-lived radioactive isotopes such as 3.77-min V/sup 52/ and 14.6-min Mo/sup 101/. The analytical results obtained were compared to the results obtained from standard chemical and instrumental analytical methods and, where possible, to activation analysis results obtained from longer-lived isotopes of the same element. Further work is in progress to improve the procedures, to evaluate the reproducibility and accuracy of the methods, and to evaluate their usefulness on a wide variety of sample matrices. The research on short-lived metastable isomers showed that 1.7-min W/sup 185m/ is not produced in sufficiently high yield for the development of a supplementary analytical scheme for natural tungsten although ...

1962-09-19

446

Nuclear Medicine Program progress report for quarter ending September 30, 1992  

Energy Technology Data Exchange (ETDEWEB)

The radioiodination and in vivo evaluation of p-iodocaramiphen a muscarinic antagonist which binds with high affinity to the M[sub 1] receptor subtype in vitro are described. Biodistribution studies in female Fischer rats demonstrated that [[sup 125]I]-piodocaraminphen had significant cerebral localization, but the uptake did not demonstrate specific uptake in those cerebral regions rich in muscarinic receptors, and radioactivity washed out rapidly from the brain. In addition there was no significant blockage of activity when the rats were preinjected with quinuclidinyl benzilate. These results suggest that p-iodocaramiphen is not a good candidate for the in vivo study of M[sub 1] muscarinic receptor populations by SPECT. Because of the widespread interest and expected importance of the availability of large amounts of tungsten-188 required for the tungsten-188/rhenium-188 generator systems, we have investigated the large-scale production of tungsten-188 in the ORNL HFIR. We have also ...

1992-12-01

447

Molecular orbitals of nucleons in nucleus-nucleus collisions  

International Nuclear Information System (INIS)

A formalism for the dynamical treatment of the molecular orbitals of valence nucleons in nucleus-nucleus collisions is developed with the use of the coupled-reaction-channel (CRC) method. The Coriolis coupling effects as well as the finite mass effects of the nucleon are taken into account in this model, of rotating molecular orbitals, RMO. First, the validity of the concept is examined from the viewpoint of the multi-step processes in a standard CRC calculation for systems containing two identical [core] nuclei. The calculations show strong CRC effects particularly in the case where the mixing of different l-parity orbitals - called hybridization in atomic physics - occurs. Then, the RMO representation for active nucleons is applied to the same systems and compared to the CRC results. Its validity is investigated with respect to the radial motion (adiabaticity) and the rotation of the molecular axis (radial and rotational coupling). Characteristic molecular orbitals of covalent ...

448

Making porous membranes by chemical etching of heavy-ion tracks in {beta}-PVDF films  

Energy Technology Data Exchange (ETDEWEB)

Production of porous membranes using heavy ion bombardment and subsequent chemical etching of poly(vinylidene difluoride) (PVDF) films has been reported several years ago. However, porous membranes with pore diameter in the nanometer scale requires a better understanding of the chemical etching mechanism. In this work PVDF foils irradiated with Sn ions (2.85 MeV per nucleon) were exposed to several etching conditions which involved permanganate oxidation in different alkaline environments. The solution of KOH 9 mol L{sup -1} and saturated in KMnO{sub 4} was the best etching reactant for PVDF. Functional groups created in the alkaline and oxidative attack by permanganate were studied by FT-IR and UV-vis spectroscopy. The spectroscopic data reveals that the formation of pores occurs by a two-step mechanism: (i) double bonds as a result of dehydrofluorination induced by alkaline media and (ii) oxidation of these double bonds in permanganate solution. The etching ...

2005-07-01

449

High-power, high-brightness pseudospark-produced electron beam driven by improved pulse line accelerator  

Energy Technology Data Exchange (ETDEWEB)

A high power (200KV), intense current density, low emittance (71mmmrad), high brightness (8x10{sup 10}A/m rad) electron beam was generated in the 10cm long, high-voltage-resistive multi-gap hollow cathode pseudospark chamber filled with 15pa nitrogen and driven by an improved pulse line accelerator. The beam was ejected with the 1mm diameter, the 2.2KA beam current, and the 400ns pulse length, and could propagated 20cm in the drift tube. At a distance of 5cm from the anode it penetrated consecutively an acid-sensitive discoloring film and a 0.05mm-thick copper foil both stuck closely, left 0.6mm and 0.3mm holes on them, respectively. That 10 shots on an acid-sensitive film produced a hole of 1.6mm at 7cm downstream of anode showed its good repeatability. After 60 shots the pseudospark discharge chamber was disassembled and observed that almost no destructive damage traces left on the surfaces of its various electrodes and insulators. But on almost all the surfaces of changeable central ...

1995-12-31

450

Effects of mesh-assisted carbon plasma immersion ion implantation on the surface properties of insulating silicon carbide ceramics  

International Nuclear Information System (INIS)

Plasma immersion ion implantation (PIII) is an effective materials modification and synthesis technique but has seldom been applied to ceramic materials due to the high electrical resistance that reduces the ion bombardment energy and sometimes causes serious electrical arcing in the instrument. Even in cases where PIII is applicable, the surface properties of the implanted insulating materials can be seriously affected due to the low ion energy and materials damage from electrical arcing. In order to enhance the surface and mechanical properties such as wear resistance of ceramic materials used in many industrial applications, surface modification is needed. In this work, we conduct carbon implantation into sintered #alpha#-SiC (silicon carbides that are widely used in vacuum ceramic bearings) using mesh-assisted plasma immersion ion implantation to enhance the surface properties. The use of a conducting grid is necessitated by the high electrical resistance that ...

2004-03-01

451

Chemistry of berkelium: a review  

Energy Technology Data Exchange (ETDEWEB)

Element 97 was first produced in December 1949, by the bombardment of americium-241 with accelerated alpha particles. This new element was named berkelium (Bk) after Berkeley, California, the city of its discovery (Thompson, Ghiorso, and Seaborg, Phys. Rev. 77, 838 (1950); 80, 781 (1950)). In the 36 years since the discovery of Bk, a substantial amount of knowledge concerning the physicochemical properties of this relatively scarce transplutonium element has been acquired. All of the Bk isotopes of mass numbers 240 and 242 through 251 are presently known, but only berkelium-249 (..beta../sup -/ decay, 0.125 MeV, t/sub 1/2/ = 325 days) is available in sufficient quantities for bulk chemical studies. About 0.7 gram of this isotope has been isolated at the HFIR/TRU Complex in Oak Ridge, Tennessee in the last 18 years. Over the same time period, the scale of experimental work using berkelium-249 has increased from the tracer level to bulk studies at the microgram level ...

1985-01-01

452

Charge and fluence lifetime measurements of a dc high voltage GaAs photogun at high average current  

Energy Technology Data Exchange (ETDEWEB)

GaAs-based dc high voltage photoguns used at accelerators with extensive user programs must exhibit long photocathode operating lifetime. Achieving this goal represents a significant challenge for proposed high average current facilities that must operate at tens of milliamperes or more. This paper describes techniques to maintain good vacuum while delivering beam, and techniques that minimize the ill effects of ion bombardment, the dominant mechanism that reduces photocathode yield of a GaAs-based dc high voltage photogun. Experimental results presented here demonstrate enhanced lifetime at high beam currents by: (a) operating with the drive laser beam positioned away from the electrostatic center of the photocathode, (b) limiting the photocathode active area to eliminate photoemission from regions of the photocathode that do not support efficient beam delivery, (c) using a large drive laser beam to distribute ion damage over a larger area, and (d) by applying a ...

2011-04-01

453

X-ray ablation measurements and modeling for ICF applications  

Energy Technology Data Exchange (ETDEWEB)

X-ray ablation of material from the first wall and other components of an ICF (Inertial Confinement Fusion) chamber is a major threat to the laser final optics. Material condensing on these optics after a shot may cause damage with subsequent laser shots. To ensure the successful operation of the ICF facility, removal rates must be predicted accurately. The goal for this dissertation is to develop an experimentally validated x-ray response model, with particular application to the National Ignition Facility (NIF). Accurate knowledge of the x-ray and debris emissions from ICF targets is a critical first step in the process of predicting the performance of the target chamber system. A number of 1-D numerical simulations of NIF targets have been run to characterize target output in terms of energy, angular distribution, spectrum, and pulse shape. Scaling of output characteristics with variations of both ...

1996-09-01

454

Target fabrication of low-density and nano porous materials to generate extreme ultraviolet (EUV)  

Energy Technology Data Exchange (ETDEWEB)

Our institute has been investigating laser-produced tin, lithium and xenon plasma for extreme ultraviolet (EUV) light source of EUV lithography system, and found the highest conversion efficiency of 3% at 13.5 nm in 2% bandwidth. In the present paper, we introduce fabrication methods of density-controlled tin targets to generate relatively monochromatic EUV, and higher conversion efficiency than bulk tin. The first method is the nano-template method, where liquid tin solution was immersed into a polymer film with monodispersed size nano-particle. The density can be controlled by tin concentration of the solution. The target can be classified into mass-limited target. We have shown a tendency of monochromatic EUV emission around 13.5 nm with decreasing of tin density. The intensity was higher than tin foil with bulk density. The tendency has a merit to mitigate heat effect of the first EUV mirror. The fabrication method has ...

2006-06-15

455

Target fabrication of low-density and nano porous materials to generate extreme ultraviolet (EUV)  

International Nuclear Information System (INIS)

Our institute has been investigating laser-produced tin, lithium and xenon plasma for extreme ultraviolet (EUV) light source of EUV lithography system, and found the highest conversion efficiency of 3% at 13.5 nm in 2% bandwidth. In the present paper, we introduce fabrication methods of density-controlled tin targets to generate relatively monochromatic EUV, and higher conversion efficiency than bulk tin. The first method is the nano-template method, where liquid tin solution was immersed into a polymer film with monodispersed size nano-particle. The density can be controlled by tin concentration of the solution. The target can be classified into mass-limited target. We have shown a tendency of monochromatic EUV emission around 13.5 nm with decreasing of tin density. The intensity was higher than tin foil with bulk density. The tendency has a merit to mitigate heat effect of the first EUV mirror. The fabrication method has ...

2006-06-01

456

Pipe whip experiments involving impacts between pipes  

International Nuclear Information System (INIS)

Dynamic pipe impact tests were performed in order to determine the impact conditions for which a 2 inch Schedule 80 carbon steel target pipe would not be broken if it were impacted during a pipe whip event created by a postulated break of an adjacent larger parallel pipe. Such pipe/pipe impact scenarios are of special interest for the feeder pipes of a CANDU reactor because the large number of closely spaced parallel feeder pipes that carry coolant between large primary system pipes and individual fuel channels in the reactor core makes it impractical to consider providing feeder pipe whip restraints. The testing which was performed involved simulating the behaviour of 3 inch and larger whipping pipes in order to study their impact with 2 inch target pipes pressurized at about 9 MPa with water at a temperature of about 290"0C. In a conservative simulation of the worst pipe/pipe impact event which it has been predicted could occur for adjacent ...

457

Empirical Evaluation of a New Method for Calculating Signal to Noise Ratio (SNR) for Microarray Data Analysis  

Energy Technology Data Exchange (ETDEWEB)

Signal-to-noise-ratio (SNR) thresholds for microarray data analysis were experimentally determined with an oligonucleotide array that contained perfect match (PM) and mismatch (MM) probes based upon four genes from Shewanella oneidensis MR-1. A new SNR calculation, called signal to both standard deviations ratio (SSDR) was developed, and evaluated along with other two methods, signal to standard deviation ratio (SSR), and signal to background ratio (SBR). At a low stringency, the thresholds of SSR, SBR, and SSDR were 2.5, 1.60 and 0.80 with oligonucleotide and PCR amplicon as target templates, and 2.0, 1.60 and 0.70 with genomic DNA as target templates. Slightly higher thresholds were obtained at the high stringency condition. The thresholds of SSR and SSDR decreased with an increase in the complexity of targets (e.g., target types), and the presence of background DNA, and a decrease in the composition ...

2008-03-06

458

Co-product extraction studies on N-reactor PT-57 target materials  

International Nuclear Information System (INIS)

Single pellets (of approximately 70 g each) of irradiated lithium aluminate target from N-Reactor test PT-57 were used in a series of experiments to determine the extent to which the product tritium can be recovered by (a) vacuum outgassing of the target (thermal extraction-TX) and (b) in-vacuo chemical dissolution of the target in molten sodium tetraborate (flux extraction-FX). Five TX runs and seven FX runs were made. Thirty-five percent of the tritium was recovered in a form non-condensable at -196"0C. The remainder was recovered in a condensable form (as T_2O, HTO, etc.). Post-extraction analysis of the melt from the seven flux extractions showed that a maximum of 2 percent of the original amount of tritium remained and that target dissolution was essentially complete in 12 hours. Flux extraction of two pellets which had been subjected to thermal extraction showed less than 0.4 percent of the ...

459

Activation analysis of trace elements in titanium-molybdate target used for pre-formed TiMo gel based "9"9"mTc generator production and radionuclidic impurity of "9"9"mTc pertechnetate eluate  

International Nuclear Information System (INIS)

A gel-type "9"9Mo-"9"9"mTc generator using Titanium-Molybdate target (TiMo-target) as column packing was developed in Radioisotope Department, the Dalat Nuclear Research Institute [1]. The concentration of trace elements in TiMo-target and radionuclidic purity in "9"9"mTc solution eluted from this type of generator were studied for quality control purpose. The monostandard method in neutron activation analysis has been applied to determine the concentration of trace impurities in titanium-molybdate target. For neutron activation analysis, TiMo samples were irradiated in the different channels of nuclear reactor IVV-9 at a neutron flux of maximum 2.1 x 10"1"3 n.cm"-"2s"-"1. The following chemical element impurities were determined: Na, W, Co, Fe, Zn, Ag, Sb and Cr. The gamma ray emitted nuclides found in "9"9"mTc solution eluted from our "9"9"mTc generator were the following: "6"5Zn, "6"0Co, "1"1"0"mAg, ...

2004-06-01

460

Separation of "1"8"7","1"8"8Pt and "1"8"7","1"8"8Ir produced in "1"1B"4"+ irradiated tantalum target  

International Nuclear Information System (INIS)

Heavy ion irradiation on tantalum metal target with 57 MeV "1"1B"4"+ leads to the production of no-carrier-added radioisotopes of platinum, "1"8"7","1"8"8Pt and iridium, "1"8"7","1"8"8Ir in the matrix, which have been effectively separated from the bulk target and from each other with suitable anion exchangers employing liquid-liquid extraction (LLX). Also "1"8"8","1"8"9Pt and "1"8"8","1"8"9Ir radionuclides have been produced, from their short-lived precursors "1"8"8","1"8"9Au, in "1"2C"6"+ irradiated tantalum matrix. Gamma-spectroscopy has been utilised to determine the production, extent of separation and purity of the radiotracers at different stages of the experiment. (orig.)

461

Search for Extra-Terrestrial planets: The DARWIN mission - Target Stars and Array Architectures  

CERN Document Server

The DARWIN mission is an Infrared free flying interferometer mission based on the new technique of nulling interferometry. Its main objective is to detect and characterize other Earth-like planets, analyze the composition of their atmospheres and their capability to sustain life, as we know it. DARWIN is currently in definition phase. This PhD work that has been undertaken within the DARWIN team at the European Space Agency (ESA) addresses two crucial aspects of the mission. Firstly, a DARWIN target star list has been established that includes characteristics of the target star sample that will be critical for final mission design, such as, luminosity, distance, spectral classification, stellar variability, multiplicity, location and radius of the star. Constrains were applied as set by planet evolution theory and mission architecture. Secondly, a number of alternative mission architectures have been evaluated on the basis of interferometer ...

2005-01-01

462

Safety and Environmental Aspects of Inertial Fusion Energy: An Overview of Recent Activities and Developments in the United States  

International Nuclear Information System (INIS)

During the past 2 yr, significant progress has been made in several areas related to the safety and environmental (S and E) aspects of inertial fusion energy (IFE). An updated methodology has been developed, and accident analyses have been performed for two IFE conceptual power plants and a target fabrication facility. Parallel to the consequence analyses of different accident scenarios, ongoing studies of accident initiating events are being used to support safety assessment and create a basic framework of types of events to consider in future risk characterization of new plant designs. Target designers/fabrication specialists have been provided with ranking information related to the S and E characteristics of candidate target materials. We have revisited waste management options for IFE, introducing the concept of clearance versus the traditional shallow land burial. A brief summary of results in each of these activities ...

2003-05-01

463

Recent neutron scattering work at the University of Lowell  

International Nuclear Information System (INIS)

Neutron elastic and inelastic scattering cross sections of _2_3_8U and _2_3_2Th have been measured at the University of Lowell for states below 1.8 MeV. A time-of-flight (TOF) spectrometer was used. The disc-shaped scatterer was oriented to optimize energy resolutions for 200-to-500-keV neutrons. Neutrons were obtained via the _7Li(p,n)_7Be reaction. Targets were prepared by in-situ evaporation of Li onto a Ta backing. During the evaporation, the target thickness was monitored using a 5-m-flight-path TOF spectrometer; a typical target had a neutron thickness from 8 to 10 keV for Esub(p) = 2.25.MeV. Spectra were analyzed using the unfolding code TINA; standard peak shapes were obtained from codes LAGUE and LAPA. Results obtained will be presented.

1981-11-23

464

Quality Management for Neutron Transmutation Doping of Silicon Ingot in HANARO  

Energy Technology Data Exchange (ETDEWEB)

By using this doping method, silicon semiconductors with extremely uniform dopant distributions can be produced, and this is the dominant advantage of NTD compared with a conventional chemical doping. Good uniformity of a dopant concentration is usually required for high power applications such as thyristor (SCR), IGBT, IGCT and GTO and for special sensors. Achieving an accurate neutron fluence corresponding to a target resistivity as well as a uniform irradiation is the prime target of a neutron irradiation for NTD. Generally, in order to reach an accurate neutron fluence, a real time neutron flux is monitored by a neutron detector such as a Self-powered Neutron Detector(SPND). And, after an irradiation, the total irradiation fluence is confirmed by measuring the absolute activity of a neutron activation sample that has been irradiated with a silicon ingot, and thus the SPND can be properly calibrated. Excellent irradiation uniformity and a ...

2007-10-15

465

Plasma dynamics in the PF-1000 device under full-scale energy storage: II. Fast electron and ion characteristics versus neutron emission parameters and gun optimization perspectives  

International Nuclear Information System (INIS)

Electron and ion beam dynamics of the PF-1000 facility were investigated for the first time at its upper energy limit (?1 MJ) in relation to neutron emission, the pinch's plasma ('target') characteristics and some other parameters with the help of a number of diagnostics with ns temporal resolution. Special attention was paid to the temporal and the spatial cross correlations of different phenomena. Results of these experiments are in favour of a neutron emission model based on ion beam-plasma interaction with three important features: (1) the plasma target is hot and confined during a few 'inertial confinement times'; (2) the ions of the main part of the beam are magnetized and entrapped around the pinch plasma target for a period longer than the characteristic time of the plasma inductive storage system and (3) ion-ion collisions (both fusion collisions, due to head-on impacts and Coulomb collisions) are responsible for ...

2007-06-21

466

Pipe whip studies  

Energy Technology Data Exchange (ETDEWEB)

An experimental and analytical study was performed to improve understanding of the dynamic impact behavior of carbon steel pipes. The test program addressed two types of pipe impact scenarios using both 2- and 4-in. Sch-80 pipes and elbows. Projectile-on-pipe tests simulated the behavior of a stationary target pipe which is impacted at its center by a larger, more rigid whipping pipe. These target pipes, which contained non-flowing water at about 290{degree}C temperature and ca 8.5 megapascals pressure, exhibited a peak deformation of up to 45% reduction in their diameter. For each test condition, the local deformation at the impact zone is a function of the peak impact force and impact velocity. Pipe-on-wall tests simulated the impact of an elbow at the free end of a cantilevered whipping pipe with a rigid barrier. The peak crush of the impact zone of the elbows was a function of peak impact force. Numerical analyses of dynamic impact tests ...

1984-06-01

467

Nuclear multifragmentation experiment at the KEK 12 GeV PS. The first results of the KEK-PS E337 experiment  

Energy Technology Data Exchange (ETDEWEB)

A KEK-PS experiment E337 `Angular correlation of intermediate mass fragments emitted from the target multifragmentation reactions with 12 GeV protons` is an extension of the E288 performed a few years ago. The E288 revealed that the proton-induced target multifragmentation reactions at 12 GeV showed quite interesting phenomena such as 70 degree peaking angular distributions for intermediate mass fragments. In December, 1955, the test experiment with 12 GeV protons was started at KEK using this newly constructed counter array of 37 Bragg Curve Counters. The main production experiment was performed in April and May in 1996 after debugging the new counter system and DAQ system, as well as EP1-B beam line. Data with Au, Tm, Sm and Ag targets were successfully accumulated. The data are in the analysis stage, and several interesting features of high energy nuclear reactions have already been seen. (G.K.)

1997-05-01

468

Metallography of pitted aluminum-clad, depleted uranium fuel  

Energy Technology Data Exchange (ETDEWEB)

The storage of aluminum-clad fuel and target materials in the L-Disassembly Basin at the Savannah River Site for more than 5 years has resulted in extensive pitting corrosion of these materials. In many cases the pitting corrosion of the aluminum clad has penetrated in the uranium metal core, resulting in the release of plutonium, uranium, cesium-137, and other fission product activity to the basin water. In an effort to characterize the extent of corrosion of the Mark 31A target slugs, two unirradiated slug assemblies were removed from basin storage and sent to the Savannah River Technology Center for evaluation. This paper presents the results of the metallography and photographic documentation of this evaluation. The metallography confirmed that pitting depths varied, with the deepest pit found to be about 0.12 inches (3.05 nun). Less than 2% of the aluminum cladding was found to be breached resulting in less than 5% of the uranium surface ...

1994-12-01

469

Measurement of electron energy fluence spectra from electron beam therapy machines  

Energy Technology Data Exchange (ETDEWEB)

A technique capable of measuring the electron energy fluence spectra in a scattering medium was designed. These measurements were performed by setting a bremsstrahlung conversion target on the surface of a phantom, at an intermediate depth, and at a depth equal to electron mean range. The bremsstrahlung produced by the deceleration of electrons in the target was passed through an air channel in the phantom and passed forward by a pinhole collimator into a Na(Tl) detector. The measured pulse height data were unfolded to correct for the distortion of the spectrometer system by using the FORIST unfolding code. The unfolded bremsstrahlung spectra represent the electron energy fluence spectra convolution with the bremsstrahlung produced in the target. To generate the electron energy fluence spectra, the unfolded bremsstrahlung spectra were deconvoluted by using the MAZE2 unfolding code. CYLTRAN, a coupled electron-photon Monte ...

1984-01-01

470

Inclusive K{sup +}-meson production in proton-nucleus interactions  

Energy Technology Data Exchange (ETDEWEB)

The production of K{sup +}-mesons in pA(A=D,C,Cu,Ag,Au) collisions has been investigated at the COoler SYnchrotron COSY-Juelich for beam energies T{sub p}=1.0-2.3 GeV. Double differential inclusive pC cross-sections at forward angles {theta}{sub K+}<12 as well as the target mass dependence of the K{sup +} momentum spectra have been measured with the ANKE spectrometer. Far below the free NNthreshold at T{sub NN}=1.58 GeV the spectra reveal a high degree of collectivity in the target nucleus. From the target mass dependence of the cross-sections at higher energies, the repulsive in-medium potential of the K{sup +}-mesons can be deduced. Using pNcross-section parameterisations from the literature and our measured pD data we derive a cross-section ratio {sigma}(pn{yields}K{sup +}X)/{sigma}(pp{yields}K{sup +}X) {proportional_to}(3-4). (orig.)

2004-11-01

471

Experimental studies of pipe whip and impact: Final report  

Energy Technology Data Exchange (ETDEWEB)

An experimental and computational study was undertaken to estimate the effects of pipe rupture and induced pipe whip impact on surround structures considered either as rigid or deformative such as concrete slabs. This program included sixteen tests using 3 inch schedule 80 (or 10) pipes made of carbon steel similar to A106 grade B. The study consisted of tests on rigid target and on concrete slab. The investigation of whip phase and impact phase was done separately for each test. For pipe impact on rigid targets, the impact forces are found to be directly related to the crush strength of the pipe and the general pipe deformation following the impact. For pipe impact on concrete slabs, the response of the target to the pipe impact needs to take into account the local effect such as penetration and localized damage on the slab. The test matrix covered a broad range of geometric parameters. It provides a significant data base ...

1987-02-01

472

Emission factors of polybrominated diphenyl ethers (PBDEs) from plastics processing and recycling facilities  

Energy Technology Data Exchange (ETDEWEB)

With regard to polybrominated diphenyl ether (PBDE), there is few scientific knowledge on the emission patterns into the environment and exposure pathways to humans, and basic information is insufficient to consider what measures effective are. For the purpose of promoting risk reduction of target substances more effectively and efficiently, it is desirable to comprehend accurately the causal chain from the target substances utilization to the risk intake, and to evaluate the measures covering the whole applications of target substances. As the existing researches on the PBDE emission inventory, there are EU risk assessment report (European Chemical Bureau 2000, 2002, 2003), Danish EPA (1999), Palm et al.(2002) and Alcock et al. (2003). In addition, emissions of DecaBDE are published in TRI (Toxic Release Inventory) of US EPA. However, the primary information of the previous inventories is often the same and estimations ...

2004-09-15

473

Comparative evaluation of similarity measures for the rigid registration of multi-modal head images  

Energy Technology Data Exchange (ETDEWEB)

Image registrations that are based on similarity measures simply adjust the parameters of an appropriate spatial transformation model until the similarity measure reaches an optimum. The numerous similarity measures that have been proposed in the past are differently sensitive to imaging modality, image content and differences in the image content, selection of the floating and target image, partial image overlap, etc. In this paper, we evaluate and compare 12 similarity measures for the rigid registration. To study the impact of different imaging modalities on the behavior of similarity measures, we have used 16 CT/MR and 6 PET/MR image pairs with known 'gold standard' registrations. The results for the PET/MR registration and for the registration of CT to both rectified and unrectified MR images indicate that mutual information, normalized mutual information and the entropy correlation coefficient are the most accurate similarity measures and ...

2007-09-21

474

Closing the loop in cortically-coupled computer vision: a brain-computer interface for searching image databases.  

Science.gov (United States)

We describe a closed-loop brain-computer interface that re-ranks an image database by iterating between user generated 'interest' scores and computer vision generated visual similarity measures. The interest scores are based on decoding the electroencephalographic (EEG) correlates of target detection, attentional shifts and self-monitoring processes, which result from the user paying attention to target images interspersed in rapid serial visual presentation (RSVP) sequences. The highest scored images are passed to a semi-supervised computer vision system that reorganizes the image database accordingly, using a graph-based representation that captures visual similarity between images. The system can either query the user for more information, by adaptively resampling the database to create additional RSVP sequences, or it can converge to a 'done' state. The done state includes a final ranking of the image database and also a 'guess' of the ...

2011-05-12

475

Anti-cancer drug loaded iron-gold core-shell nanoparticles (Fe@Au) for magnetic drug targeting.  

Science.gov (United States)

Magnetic drug targeting, using core-shell magnetic carrier particles loaded with anti-cancer drugs, is an emerging and significant method of cancer treatment. Gold shell-iron core nanoparticles (Fe@Au) were synthesized by the reverse micelle method with aqueous reactants, surfactant, co-surfactant and oil phase. XRD, XPS, TEM and magnetic property measurements were utilized to characterize these core-shell nanoparticles. Magnetic measurements showed that the particles were superparamagnetic at room temperature and that the saturation magnetization decreased with increasing gold concentration. The anti-cancer drug doxorubicin (DOX) was loaded onto these Fe@Au nanoparticle carriers and the drug release profiles showed that upto 25% of adsorbed drug was released in 80 h. It was found that the amine (-NH2) group of DOX binds to the gold shell. An in vitro apparatus simulating the human circulatory system was used to determine the retention of these nanoparticle ...

2010-09-01

476

A heterogeneous dose distribution in simultaneous integrated boost: the role of the clonogenic cell density on the tumor control probability  

Energy Technology Data Exchange (ETDEWEB)

IMRT with inverse planning allows simultaneous integrated boost strategies that exploit the heterogeneous dose distribution within the planning target volumes (PTVs). In this scenario, the location of cold spots within the target becomes a crucial issue and has to be related to the distribution of the clonogenic cell density (CCD). The main aim of this work is to provide the means to calculate the optimal prescription dose in a relative inhomogeneous dose distribution. To achieve this, the prescription dose has to be assigned to obtain the same tumor control probability (TCP) as the ideal homogeneous distribution, taking into account different CCDs in different PTVs (i.e. visible and subclinical regions). An adapted formulation of the linear-quadratic model, within the F-factor formalism, has been derived to preserve a chosen TCP value for the whole target volume. The F-factor has been investigated to show its potential ...

2008-10-07

477

Low temperature partly ionized plasma in magnetic fusion devices: Present status and prospects  

Energy Technology Data Exchange (ETDEWEB)

The most striking achievement in magnetic fusion experiments during last few years was the discovery of plasma detachment from material targets, a much needed effect for plasmas with high power fusion parameters. Due to the very low heat loads on the targets observed in these regimes and potentially low erosion of the targets, detached regimes look attractive from the International Thermonuclear Experimental Reactor (ITER) design point of view. Thus the author has experimental proof for the possibility for a co-existence of fusion relevant hot plasma in the core and a low temperature partly ionized plasma at the edge of magnetic fusion device. Although somewhat similar behavior of edge plasma was considered theoretically even before plasma detachment was found experimentally, it was not clear in the beginning how these theoretical and experimental findings would fit together. Now, after a few years of intensive additional ...

1998-12-31

478

ISDD: A Computational Model of Particle Sedimentation, Diffusion and Target Cell Dosimetry for In Vitro Toxicity Studies  

Energy Technology Data Exchange (ETDEWEB)

Background: The difficulty of directly measuring cellular dose is a significant obstacle to application of target tissue dosimetry for nanoparticle and microparticle toxicity assessment. As a consequence, the target tissue paradigm for dosimetry and hazard assessment of nanoparticles has largely been ignored in favor of using metrics of exposure (e.g. ?g particle/mL culture medium, particle surface area/mL, particle number/mL). We have developed a computational model of solution particokinetics (sedimentation, diffusion) and dosimetry for non-interacting spherical particles and their agglomerates in monolayer cell culture systems. Particle transport to cells is calculated by simultaneous solution of Stokes Law (sedimentation) and the Stokes-Einstein equation (diffusion). Results: The In vitro Sedimentation, Diffusion and Dosimetry model (ISDD) was tested against measured transport rates or cellular doses for multiple sizes of polystyrene ...

2010-11-30

479

What horizon for targeting inflation?  

British Library Electronic Table of Contents (United Kingdom)

We investigate optimal horizons for targeting inflation in response to different shocks and their properties. Our analysis is based on a well specified macroeconometric model of Norway. We find that optimal horizons are highly shock-specific and do not increase with concern for output and/or interest rate fluctuations beyond some shock-specific levels. Optimal horizons increase with the degree of persistence in shocks while they are not affected by the size of a shock unless the central bank is averse to interest rate volatility. In the face of multiple shocks, however, sizes as well as signs of shocks become important for optimal horizons even when the central bank is not averse to interest rate volatility. This is because shocks of different signs and sizes may amplify or outweigh each o...

2010-01-01

480

Targeting mid-size customers through innovative pricing strategies: An approach to assessing customer contestability  

Energy Technology Data Exchange (ETDEWEB)

This paper outlines an approach to develop estimates of individual customer contestability using a combined statistical and engineering analysis. The approach is targeted for use for mid-size commercial and industrial customers who are not being considered for individual flexible pricing contracts. Contestability is defined as the potential lost revenue associated with customers leaving the utility or significantly reducing electricity purchases. Contestability is modeled from the customer`s perspective using a two-stage decision process. In the first stage, the customer decides if he will continue to purchase electricity from the utility (referred to as customer retention), and in the second stage, the customer determines the amount of electricity purchased (referred to as load retention). Measures of individual customer contestability will be key factors in developing market segments and new rate offerings in future energy markets.

1996-03-01

481

Selegiline-functionalized, PEGylated poly(alkyl cyanoacrylate) nanoparticles: Investigation of interaction with amyloid-b peptide and surface reorganization  

British Library Electronic Table of Contents (United Kingdom)

Alzheimer's disease (AD) is a neurodegenerative disorder for which the research of new treatments is highly challenging. Since the fibrillogenesis of amyloid-b peptide 1-42 (Ab1-42) peptide is considered as a major cause of neuronal degeneration, specific interest has been focused on aromatic molecules for targeting this peptide. In this paper, the synthesis of selegiline-functionalized and fluorescent poly(alkyl cyanoacrylate) nanoparticles (NPs) and their evaluation for the targeting of the Ab1-42 peptide are reported. The synthetic strategy relied on the design of amphiphilic copolymers by tandem Knoevenagel-Michael addition of cyanoacetate derivatives, followed by their self-assembly in aqueous solutions to give the corresponding NPs. Different cyanoacetates were used: (i) hexadecyl cy...

2011-01-01

482

Purification of cyclotron-produced "2"0"3Pb for labeling Herceptin  

International Nuclear Information System (INIS)

A simple and rapid procedure was developed for the purification of cyclotron-produced "2"0"3Pb via the "2"0"3Tl(d,2n) "2"0"3Pb reaction. A Pb(II) selective ion-exchange resin, with commercial name Pb Resin from Eichrom Technologies, Inc., was used to purify "2"0"3Pb from the cyclotron-irradiated Tl target with excellent recovery of the enriched Tl target material. The purified "2"0"3Pb was used to radiolabel the monoclonal antibody Herceptin. The in vitro and in vivo properties of the "2"0"3Pb radioimmunoconjugate were evaluated.

2005-04-01

483

Prediction of drug particle size and content uniformity in low-dose solid dosage forms  

British Library Electronic Table of Contents (United Kingdom)

Drug particle size distribution has a profound impact to the content uniformity in low-dose solid drug products. We derived theoretically the skewness of potency distribution as a function of particle size distribution and target dose. It was demonstrated that both skewness and coefficient of variation diverge simultaneously with inverse square root of the target dose. This scaling relation was observed in recent experiment and was verified by Monte Carlo (MC) simulation, which was employed for the first time to solve for the full potency distribution from a random retrieving model. When tested against the criteria from USP uniformity of dosage units, MC simulation showed a striking anisotropic distribution of the data. This suggests a full-scale consideration of the potency distribu...

2010-01-01

484

Parameter study of the LIFE engine nuclear design  

British Library Electronic Table of Contents (United Kingdom)

LLNL is developing the nuclear fusion based Laser Inertial Fusion Energy (LIFE) power plant concept. The baseline design uses a depleted uranium (DU) fission fuel blanket with a flowing molten salt coolant (flibe) that also breeds the tritium needed to sustain the fusion energy source. Indirect drive targets, similar to those that will be demonstrated on the National Ignition Facility (NIF), are ignited at 13Hz providing a 500MW fusion source. The DU is in the form of a uranium oxycarbide kernel in modified TRISO-like fuel particles distributed in a carbon matrix forming 2-cm-diameter pebbles. The thermal power is held at 2000MW by continuously varying the 6Li enrichment in the coolants. There are many options to be considered in the engine design including target yield, U-to-C ratio in th...

2010-01-01

485

Isolation of functional mitochondria from rat kidney and skeletal muscle without manual homogenization  

British Library Electronic Table of Contents (United Kingdom)

Isolation of functional and intact mitochondria from solid tissue is crucial for studies that focus on the elucidation of normal mitochondrial physiology and/or mitochondrial dysfunction in conditions such as aging, diabetes, and cancer. There is growing recognition of the importance of mitochondria both as targets for drug development and as off-target mediators of drug side effects. Unfortunately, mitochondrial isolation from tissue is generally carried out using homogenizer-based methods that require extensive operator experience to obtain reproducible high-quality preparations. These methods limit dissemination, impede scale-up, and contribute to difficulties in reproducing experimental results over time and across laboratories. Here we describe semiautomated methods to disrupt tissue ...

2011-01-01

486

Inelastic electron--dipole-molecule scattering at sub-milli-electron-volt energies: CH_3I and CH_2Br_2  

International Nuclear Information System (INIS)

Studies of Rydberg-atom destruction in collisions with the polar targets CH_3I and CH_2Br_2 for values of principal quantum number n in the range 100--400 are reported. Analysis of the data using the essentially-free-electron model suggests that, for ultralow electron energies (#approx#80 #mu#eV to 1 meV), the cross section #sigma#(var-epsilon) for rotationally inelastic scattering of electrons by a polar target varies approximately as 1/var-epsilon, where var-epsilon is the electron energy. The Born approximation does not predict such behavior at very low collision energies, and possible reasons for this discrepancy are discussed.

487

Hsp90 gene, an additional target for discrimination between the potato cyst nematodes, Globodera rostochiensis and G. pallida, and the related species, G. tabacum tabacum  

British Library Electronic Table of Contents (United Kingdom)

The heat-shock gene, Hsp90, was targeted as a new variable genomic region to supplement other DNA-based tests for identification and discrimination of Globodera pallida, G. rostochiensis and G. tabacum tabacum. Populations of the potato cyst nematodes, G. pallida and G. rostochiensis (PCN), originating from Canada, France, Belgium and USA, together with two populations of G. tabacum tabacum from the USA and France were used for the amplification of a fragment of the Hsp90 gene. General and specific primers and probes for each species were derived from the consensus and non-consensus regions of the aligned sequences, respectively. A triplex conventional PCR assay, using a general forward and reverse or three specific reverse primers, as well as a real-time PCR using general primers and spec...

2011-01-01

488

Equilibrium headspace analysis of volatile flavor compounds extracted from soursop (Annona muricata) using solid-phase microextraction  

British Library Electronic Table of Contents (United Kingdom)

The influence of headspace solid-phase microextraction (HS-SPME) variables, namely, sample concentration, salt concentration and sample amount, on the equilibrium headspace analysis of the main volatile flavor compounds released from soursop was investigated. A total of 35 volatile compounds, comprising 19 esters, six alcohols, three terpenes, two acids, two aromatics, two ketones and an aldehyde, were identified. The results indicated that all response-surface models were significantly (p<0.05) fitted for 10 target volatile flavor compounds. The results further indicated that more than 65% of the variation in the equilibrium headspace concentrations of target volatile flavor compounds could be explained by the final reduced models, with high R2 values ranging from 0.658 to 0.944. Multiple...

2010-01-01

489

Cyclotron produced lead-203  

International Nuclear Information System (INIS)

The radioactive isotopes of lead are reviewed with respect to their choice for in vitro tracer studies. The #gamma#-photon energy and absence of particle emission in the decay of "2"0"3Pb makes it particularly suitable for these applications. Reaction yields of "2"0"3Pb using "2"0"3Tl targets and proton, deuteron, "3He and "4He beams are listed. Using the preferred reaction "2"0"3Tl (d, 2n)"2"0"3Pb with a 15 MeV deuteron beam, yields of about 75 #mu#Ci #mu#Ahr"-"1, after chemical separation, are reported. Details of target design and chemical separation are given. (U.K.).

490

A concept for the experimental determination of the nucleon electric to magnetic form factor ratio at very low Q{sup 2}  

Energy Technology Data Exchange (ETDEWEB)

Stationary target measurements of the nucleon form factors have been performed with high precision down to Q{sup 2} of {approx} 0.01 GeV{sup 2} for protons (G{sub E}{sup p}) and down to {approx} 0.1 GeV{sup 2} for neutrons (G{sub M}{sup n}). Conventional extraction using cross section and polarization measurement cannot be extended to very low values of Q{sup 2} due to inherent experimental limitations. We present a proposal for a new approach to a measurement, using colliding beams, which will extend the range of possible measurement at low Q{sup 2} by several orders of magnitude over stationary target limits.

2009-05-15

491

A concept for the experimental determination of the nucleon electric to magnetic form factor ratio at very low Q2  

International Nuclear Information System (INIS)

Stationary target measurements of the nucleon form factors have been performed with high precision down to Q2 of ? 0.01 GeV2 for protons (GEp) and down to ? 0.1 GeV2 for neutrons (GMn). Conventional extraction using cross section and polarization measurement cannot be extended to very low values of Q2 due to inherent experimental limitations. We present a proposal for a new approach to a measurement, using colliding beams, which will extend the range of possible measurement at low Q2 by several orders of magnitude over stationary target limits.

2009-05-01

492

A 24-week, multicentre, open evaluation of the clinical effectiveness of the rivastigmine patch in patients with probable Alzheimer-s disease  

British Library Electronic Table of Contents (United Kingdom)

Summary Background:- Cholinesterase inhibitors form the mainstay of treatment for persons with mild-to-moderate Alzheimer-s disease (AD). The rivastigmine patch may increase compliance and the proportion of patients maintaining an efficacious dose compared with oral cholinesterase inhibitors. Objective:- To investigate the proportion of patients who reached and maintained the target rivastigmine patch dose compared with the target rivastigmine capsule dose reported in clinical trials. Methods:- This was a multicentre, 24-week, open-label study in persons with probable AD and a Mini-Mental State Examination (MMSE) score of --10 and --26. The primary outcome was the proportion of patients (ITT population) treated with 9.5-mg/24-h rivastigmine patch for at least 8-weeks at week 24. Secondary ...

2011-01-01