UK PubMed Central (United Kingdom)

BackgroundRecent studies have shown associations between size and body proportions at birth and health outcomes throughout the life cycle, but there are few data...Full Text Available

UK PubMed Central (United Kingdom)

Mechanisms for differential regulation of gene expression may underlie much of the phenotypic variation and adaptability of malaria parasites. Here we describe transcriptional variation among culture-adapted...Full Text Available

UK PubMed Central (United Kingdom)

Objectives:Copy number variants (CNVs) have been recognized as a source of genetic variation that contributes to disease phenotypes. Alzheimer disease (AD) has high heritability...Full Text Available

UK PubMed Central (United Kingdom)

Wild-type viruses from the ViroLogic phenotype-genotype database were evaluated to determine the upper confidence limit of the drug susceptibility distributions, or “biological cutoffs,”...Full Text Available

UK PubMed Central (United Kingdom)

Toxicogenomics provides the ability to examine in greater detail the underlying molecular events that precede and accompany toxicity, thus allowing prediction of adverse events at much earlier...Full Text Available

British Library Electronic Table of Contents (United Kingdom)

We analyzed the phenotypic variation of baobab (Adansonia digitata L.) fruits from Mali to define the domestication potential of this species. 269 trees, selected from 10 provenances distributed along a rainfall gradient, were characterized. Five fruits were sampled from each tree. Total individual fruit weight was partitioned into shell, pulp, and seed weight. Ratios were calculated between pulp?+?seed and total weight, and between pulp and seed weight. For all the measured fruit traits, we detected significant differences between provenances, as well as between trees from the same provenance. Assuming that the measured traits are under genetic control, the latter facts indicate that there are considerable opportunities for tree selection on a local scale. However, candidate plus trees wi...

Science.gov (United States)

Rice is a very important food staple that feeds more than half the world's population. Two major Asian cultivated rice (Oryza sativa L.) subspecies, japonica and indica, show significant phenotypic variation in their stress responses. However, the molecular mechanisms underlying this phenotypic variation are still largely unknown. A common link among different stresses is that they produce an oxidative burst and result in an increase of reactive oxygen species (ROS). In this study, methyl viologen (MV) as a ROS agent was applied to investigate the rice oxidative stress response. We observed that 93-11 (indica) seedlings exhibited leaf senescence with severe lesions under MV treatment compared to Nipponbare (japonica). Whole-genome microarray experiments were conducted, and 1,062 probe sets were identified with gene expression level polymorphisms between the two rice cultivars in addition to differential ...

Science.gov (United States)

Twenty-two landrace-derived inbred lines from the Spanish Barley Core Collection (SBCC) were found to display high levels of resistance to a panel of 27 isolates of the fungus Blumeria graminis that exhibit a wide variety of virulences. Among these lines, SBCC145 showed high overall resistance and a distinctive spectrum of resistance compared with the other lines. Against this background, the main goal of the present work was to investigate the genetic basis underlying such resistance using a doubled haploid population derived from a cross between SBCC145 and the elite spring cultivar Beatrix. The population was genotyped with the 1,536-SNP Illumina GoldenGate Oligonucleotide Pool Assay (Barley OPA-1 or BOPA1 for short), whereas phenotypic analysis was performed using two B. graminis isolates. A major quantitative trait locus (QTL) for resistance to both isolates was identified on the long arm of chromosome 6H (6HL) and accounted for ca. 60% of the ...

British Library Electronic Table of Contents (United Kingdom)

Occurrence of genetic variants during micropropagation is occasionally encountered when the cultures are maintained in vitro for long period. Therefore, the micropropagated multiple shoots of Vanilla planifolia Andrews developed from axillary bud explants established 10 years ago were used to determine somaclonal variation using random amplified polymorphic DNA (RAPD) and intersimple sequence repeats markers (ISSR). One thousand micro-plants were established in soil of which 95 plantlets (consisting of four phenotypes) along with the mother plant were subjected to genetic analyses using RAPD and ISSR markers. Out of the 45 RAPD and 20 ISSR primers screened, 30 RAPD and 7 ISSR primers showed 317 clear, distinct and reproducible band classes resulting in a total of 30 115 bands. However, no ...

DEFF Research Database (Denmark)

Recent technological developments have facilitated intensified searches for genetic markers under selection in nonmodel species. Here, we present an approach for the identification of candidate gene variation in nonmodel organisms. We report on the characterization of 82 single nucleotide polymorphisms (SNPs) and on the development of a specific genotyping assay for 30 SNPs in 18 candidate genes for growth and reproduction in Atlantic cod (Gadus morhua). These markers can be used for scanning natural populations for signatures of selection in both contemporary and archived historical samples, for example in retrospective studies assessing the effects of environmental changes, such as increasing temperatures, and selection imposed by high fishing pressure. Furthermore, these gene markers may be of interest to aquaculture, serving as a starting point for linking phenotypic traits important for productivity with genotypes and potentially be of use ...

UK PubMed Central (United Kingdom)

Individual strains of the plant pathogenic bacterium Pseudomonas syringae vary in their ability to produce toxins, nucleate ice, and resist antimicrobial compounds. These phenotypes...Full Text Available

Science.gov (United States)

Decadal-scale climate variations over the Pacific Ocean and its surroundings are strongly related to the so-called Pacific decadal oscillation (PDO) which is coherent with wintertime climate over North America and Asian monsoon, and have important impacts on marine ecosystems and fisheries. In a near-term climate prediction covering the period up to 2030, we require knowledge of the future state of internal variations in the climate system such as the PDO as well as the global warming signal. We perform sets of ensemble hindcast and forecast experiments using a coupled atmosphere-ocean climate model to examine the predictability of internal variations on decadal timescales, in addition to the response to external forcing due to changes in concentrations of greenhouse gases and aerosols, volcanic activity, and solar cycle variations. Our results highlight that an ...

Energy Technology Data Exchange (ETDEWEB)

We have exploited {open_quotes}progeny testing{close_quotes} to map quantitative trait loci (QTL) underlying the genetic variation of milk production in a selected dairy cattle population. A total of 1,518 sires, with progeny tests based on the milking performances of >150,000 daughters jointly, was genotyped for 159 autosomal microsatellites bracketing 1645 centimorgan or approximately two thirds of the bovine genome. Using a maximum likelihood multilocus linkage analysis accounting for variance heterogeneity of the phenotypes, we identified five chromosomes giving very strong evidence (LOD score {ge} 3) for the presence of a QTL controlling milk production: chromosomes 1, 6, 9, 10 and 20. These findings demonstrate that loci with considerable effects on milk production are still segregating in highly selected populations and pave the way toward marker-assisted selection in dairy cattle breeding. 44 refs., 4 figs., 3 tabs.

British Library Electronic Table of Contents (United Kingdom)

Abstract Sperm competition theory predicts that under high risk of sperm competition, males will increase the number of sperm that they allocate to a female. This prediction has been supported by some experimental studies but not by others. Here, I conducted a meta-analysis to determine whether the increase in sperm allocation under high risk of sperm competition is a generalized response across taxa. I collected data from 39 studies and 37 species. Across taxa, males under a high risk of sperm competition respond by increasing their sperm allocation (mean effect size-=-0.32). Number of offspring did not explain a significant portion of the variation in effect sizes. A traditional meta-analysis (i.e. without phylogenetic information) described the variation among effect sizes better than a...

British Library Electronic Table of Contents (United Kingdom)

Predicted by stochastic models and observed experimentally in a number of isomerization reactions, viscosity-induced solvent effects manifest themselves in a significant departure of the reaction rates from the values expected on the basis of transition state theory. These effects are well understood within the framework of stochastic models; however, the predictive power of such models is limited by the fact that their parameters are not readily available. Experiment and molecular dynamics (MD) simulations can provide such information and can serve as the testing grounds for various stochastic models. In real solvents, a change in viscosity is inevitably associated with variation of at least one of the three factors - temperature, pressure, or solvent identity, resulting in different solv...

UK PubMed Central (United Kingdom)

The flacca tomato (Lycopersicon esculentum) mutant displays a wilty phenotype as a result of abscisic acid (ABA) deficiency. The Mo cofactor (MoCo)-containing aldehyde...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

Evolutionary theory holds that aging is a consequence of the declining force of natural selection with age. We discuss here the evidence that among the causes of aging in complex multicellular organisms, such as mammals, is the antagonistically pleiotropic effects of the cellular responses that protect the organism from cancer. Cancer is relatively rare in young mammals, owing in large measure to the activity of tumor suppressor mechanisms. These mechanisms either protect the genome from damage and/or mutations, or they elicit cellular responses--apoptosis or senescence--that eliminate or prevent the proliferation of somatic cells at risk for neoplastic transformation.We focus here on the senescence response, reviewing its causes, regulation and effects. In addition, we describe recent data that support the idea that both senescence and apoptosis may indeed be the double-edged swords predicted by the evolutionary hypothesis of antagonistic pleiotropy--protecting ...

British Library Electronic Table of Contents (United Kingdom)

The ECOSYS model is used to estimate ingestion dose in the ARGOS and RODOS decision support systems for nuclear emergency management. It is recommended that nation-specific values for several parameters are used in the model. However, this is generally overlooked when the systems are used in practice. We have estimated first year ingestion doses in two scenarios with wet and dry deposition of 137Cs, using the ECOSYS model. We calculated doses for each country using national dietary data while keeping all other parameters at their default values. These dose calculations were then used to estimate the variation in ingestion doses resulting from the variation in the diets only. The dietary data demonstrated that the average consumption of milk, meat and vegetables varied by a factor of 2-4 am...

Energy Technology Data Exchange (ETDEWEB)

Based on the CFD-code FLUENT trademark, theoretical studies were conducted of the influences of incineration chamber geometry (direct, countercurrent and center flow) on the combustion process. The boundary conditions, e.g., the thermal input and the waste grate, were kept constant. Close attention was paid to the distribution of flow, spe-cies, and temperatures. In addition, the influence of a dis-placement body at the end of the combustion chamber was tested. The variation of different wall materials and the prediction of problem areas concerning corrosion, slagging, and contamination completed the studies. Close to the chamber walls, high CO-concentrations may indi-cate corrosion; particle flow may indicate where contami-nation, slagging or erosion could occur. (orig.)

British Library Electronic Table of Contents (United Kingdom)

Data from natural runoff plots at two experimental sites in northern Iraq were used to predict soil erodibility in this semiarid region. The first site has a mean seasonal rainfall of about 400mm with the plots situated on 40% uniform slope; the soil at the site has a loam texture and belongs to the Xerorthent suborder; it has 46% of gravel by weight in its surface layer. The second site has a mean seasonal rainfall of more than 900mm with the plot situated on 17% uniform slope; the soil at the site is silty clay and belongs to the Calcixeroll suborder. At both sites, soil loss and runoff measurements were collected for two rainfall seasons. Results from both experimental sites showed that storm-to-storm variation in soil erodibility is high reflecting the importance of long term measureme...

Science.gov (United States)

A model is presented for heat and fluid flow during hammer and anvil splat cooling. Predictions are made for the effects of superheat and hammer speed on splat thickness, cooling rate, and subsequent glass formation. The regime of Newtonian heat flow is extended well beyond the previously accepted limiting value of Nusselt number. Measurements of the structure, stability, and thickness of Fe{sub 80}B{sub 20} and Pd{sub 80}Si{sub 20} hammer and anvil splats qualitatively confirm the model prediction. Variations of superheat in shock tube splats produced similar trends to those observed in the hammer and anvil device. In an attempt to vary the equivalent of hammer speed in a shock tube device, an orifice producing a supersonic shock wave was utilized. Significant splat flake thickness reductions resulted as compared to subsonic orifices.

International Nuclear Information System (INIS)

The plastic deformation behavior of formed CICC for the superconducting Tokamac fusion device was examined and appropriate manufacturing information was provided. A relation between travel of the bending roller and spring back displacement was obtained via virtual manufacturing. The radius of CICC after forming was expressed as a function of the bend-roll travel. The maximum von Mises stress after spring back was also monitored for the SAGBO prediction. Next, the variation of the CICC cross-sectional area was examined during the first turn and during conduit bending with the largest curvature. Finally, the coil radius was measured and compared with the data generated from the virtual manufacturing. The measured data showed similar pattern as predicted one. Using the mapping function found to match with the real data, the data from the virtual manufacturing may facilitate accurate manufacturing.

Science.gov (United States)

PMID:17729657

UK PubMed Central (United Kingdom)

Synthetic polymers and nanomaterials display selective phenotypic effects in cells and in the body that affect signal transduction mechanisms involved in inflammation, differentiation, proliferation,...Full Text Available

UK PubMed Central (United Kingdom)

Purpose.There is a paucity of neuron replacement studies for retinal ganglion cells. Given the complex phenotype of these neurons, replacement of ganglion cells may be impossible....Full Text Available

UK PubMed Central (United Kingdom)

Mutations in the Drosophila gene drop-dead (drd) result in early adult lethality and neurodegeneration, but the molecular identity of the drd...Full Text Available

British Library Electronic Table of Contents (United Kingdom)

Transparency is essential for normal corneal function. Recent studies suggest that corneal cells express high levels of so-called corneal crystallins, such as aldehyde dehydrogenase (ALDH) and transketolase (TKT) that contribute to maintaining cellular transparency. Stromal injury leads to the appearance of repair phenotype keratocytes, the corneal fibroblast and myofibroblast. Previous studies on keratocytes from species such as bovine and rabbit indicate that the transformation from the normal to repair phenotype is accompanied by a loss of corneal crystallin expression, which may be associated with loss of cellular transparency. Here we investigated if a similar loss occurs with human keratocyte repair phenotypes. Human corneal epithelial cells were collected by scraping and keratocytes...

Science.gov (United States)

Carbon isotope discrimination (?(13) C) is considered a useful indicator for indirect selection of grain yield (GY) in cereals. Therefore, it is important to evaluate the genetic variation in ?(13) C and its relationship with GY. A doubled haploid (DH) population derived from a cross of two common wheat varieties, Hanxuan 10 (H10) and Lumai 14 (L14), was phenotyped for ?(13) C in the flag leaf, GY and yield associated traits in two trials contrasted by water availability, specifically, rain-fed and irrigated. Quantitative trait loci (QTLs) were identified by single locus and two locus QTL analyses. QTLs for ?(13) C were located on chromosomes 1A, 2B, 3B, 5A, 7A and 7B, and QTLs for other traits on all chromosomes except 1A, 4D, 5A, 5B and 6D. The population selected for high ?(13) C had an increased frequency of QTL for high ?(13) C, GY and number of spikes per plant (NSP) when grown under rain-fed conditions and only for high ?(13) C and NSP ...

Energy Technology Data Exchange (ETDEWEB)

This paper describes the results of a model intercomparision exercise for predicting tritium transport through foodchains. Modellers were asked to assume that farmland was exposed for one hour to an average concentration in air of 10{sup 4} MBq tritium m{sup -3}. They were given the initial soil moisture content and 30 days of hourly averaged historical weather and asked to predict HTO and OBT concentrations in foods at selected times up to 30 days later when crops were assumed to be harvested. Two fumigations were postulated, one at 10.00 h (i.e., in day-light), and the other at 24.00 h (i.e., in darkness).Predicted environmental media concentrations after the daytime exposure agreed within an order of magnitude in most cases. Important sources of differences were variations in choices of numerical values for transport parameters. The different depths of soil layers used in the models appeared to make ...

UK PubMed Central (United Kingdom)

Long-term heat acclimation (AC, 30d/34°C) is a phenotypic adaptation leading to increased thermotolerance during heat stress (HS, 2 h 41°C). AC also renders protection against...Full Text Available

UK PubMed Central (United Kingdom)

G6PD activity was assayed in 20 Sardinian heterozygotes for G6PD deficiency and related to that of LDH and MDH. One of these heterozygotes showed a deficient phenotype in all her follicles, while the...Full Text Available

Science.gov (United States)

The GntR-like protein NorG has been shown to affect Staphylococcus aureus genes involved in the resistance to quinolones and ?-lactams, such as those encoding the NorB and AbcA transporters. To identify the target genes regulated by NorG, we carried out transcriptional profiling assays using S. aureus RN6390 and its isogenic norG::cat mutant. Our data showed that NorG positively affected the transcription of global regulators mgrA, arlS, and sarZ. The three putative drug efflux pump genes most positively affected by NorG were the NorB efflux pump (5.1-fold), the MmpL-like protein SACOL2566 (5.2-fold), and the BcrA-like drug transporter SACOL2525 (5.7-fold). The S. aureus predicted MmpL protein showed 53% homology with the MmpL lipid transporter of Mycobacterium tuberculosis, and the putative SACOL2525 protein showed 87% homology with the bacitracin drug transporter BcrA of Staphylococcus hominis. Two pump genes most negatively affected by NorG were NorC (4-fold) ...

Science.gov (United States)

We argue that published results demonstrate that new insights into human brain function may be obscured by poor and/or limited choices in the data-processing pipeline, and review the work on performance metrics for optimizing pipelines: prediction, reproducibility, and related empirical Receiver Operating Characteristic (ROC) curve metrics. Using the NPAIRS split-half resampling framework for estimating prediction/reproducibility metrics (Strother et al., 2002), we illustrate its use by testing the relative importance of selected pipeline components (interpolation, in-plane spatial smoothing, temporal detrending, and between-subject alignment) in a group analysis of BOLD-fMRI scans from 16 subjects performing a block-design, parametric-static-force task. Large-scale brain networks were detected using a multivariate linear discriminant analysis (canonical variates analysis, CVA) that was tuned to fit the data. We found that ...

British Library Electronic Table of Contents (United Kingdom)

Drug particle size distribution has a profound impact to the content uniformity in low-dose solid drug products. We derived theoretically the skewness of potency distribution as a function of particle size distribution and target dose. It was demonstrated that both skewness and coefficient of variation diverge simultaneously with inverse square root of the target dose. This scaling relation was observed in recent experiment and was verified by Monte Carlo (MC) simulation, which was employed for the first time to solve for the full potency distribution from a random retrieving model. When tested against the criteria from USP uniformity of dosage units, MC simulation showed a striking anisotropic distribution of the data. This suggests a full-scale consideration of the potency distribu...

Energy Technology Data Exchange (ETDEWEB)

The scope of the present article is two-fold. Firstly, to conduct an experiment to provide the temperature-time history of the cooling of a hot ball bearing in quiescent ambient air. Secondly, to predict the temporal variation of the bearing under the hypothesis of natural convection, radiation or natural convection coexists with radiation for a non-vanishing total hemispherical emissivity of the surface of the bearing. Numerical solutions of the three governing nonlinear lumped heat equations were carried out with a Runge-Kutta-Fehlberg (RKF45) algorithm accounting for automatic step size control. The experimental data was obtained with chrome steel ball bearings of diameter 0.953 cm (7/16 in) heated in an electric oven to a pre-set temperature. The heated bearing was exposed later to ambient air at atmospheric temperature and pressure. (orig.)

Energy Technology Data Exchange (ETDEWEB)

This poster presentation details the procedure that was followed for the development of the Mine Environment Neutral Drainage (MEND) manual. This manual was developed to provide a detailed summary of the important results obtained through studies sponsored by the MEND program and other studies conducted on topics related to acid mine drainage. The manual was divided into volumes dealing with topics such as summary, sampling and analysis, predictions, prevention and control, treatment, and monitoring. Details concerning the format, research conducted under the auspices of MEND, utilization and limitations, methodology, variations, costs, and references were also discussed. The author stated that the manual is to be used as a guide. The proposed English publication dates for the volumes were indicated, and they ranged from the fall of 2000 for volumes 3, 5, and 6, to the CD-ROM publication in March 2001. The French publication is expected to be ...

British Library Electronic Table of Contents (United Kingdom)

This study assessed the impact of the results of genetic testing for hereditary cancer from a multifactorial health psychology perspective, considering that emotional expression plays a key role in psychological adjustment. Measures of dispositional and transactional coping strategies, anxiety and alexithymia were filled out by 77 participants in a longitudinal study design. Statistical analyses were performed using general linear models and partial least squares path modelling, low-constraint methods that are particularly useful in the behavioural sciences. While anxiety levels prior to the result announcement were predictive of the distress experienced by noncarriers, considerable variability was observed for mutation carriers. Some subjects who had lower anxiety levels before the test d...

British Library Electronic Table of Contents (United Kingdom)

Temperature variations due to climate changes are a major cause of movements in a concrete structure, both in the longitudinal and transversal directions and between different parts of the structure. If these movements are restrained, stresses will be induced which may contribute to cracking. The movements are caused by complex interactions of several factors such as solar radiation, air temperature, long-wave heat radiation and wind speed. To predict the varying thermal conditions in a concrete structure a finite element model has been used. A validation of the model has been performed using field measurements in a concrete slab together with climate data from the Swedish Meteorological and Hydrological Institute to be able to use the model for simulations over long time periods and for s...

International Nuclear Information System (INIS)

Experimental studied of deep-inelastic scattering of neutrino, antineutrino, #mu#-mesons, electron reactions on He, D, Al, Fe, Au, Be, C, Ca, Ag, N nuclei conducted in recent years at different laboratories the world for consideration of modern status of the problems of R(x, Q"2) = #sigma#sub(L)/#sigma#sub(T) parameter variation and for study on nuclear effects in structural functions of nucleons are described in the review. Experimental information on measurements of the R parameter by data on EMS and SLAK groups is analyzed. It is noted that experimental data on measuring R contain essential errors that hampers unambiguous interpretation of data on nucleon structure. Present experimental data and predictions for explanation of the EMS effect are analyzed from the view point of quark and flucton models of a nucleus.

Energy Technology Data Exchange (ETDEWEB)

This paper discusses how specialized techniques for machine condition monitoring can help to eliminate false alarms and undetected faults, leading to a truly cost effective predictive maintenance program. It is vital to base the monitoring system on the parameter which will give the most useful information about potential faults and breakdowns. This parameter is generally agreed to be vibration. While oil debris analysis and variations in temperature, geometry and machine speed can all give advance warning of faults, no other parameter can reveal as wide a range of fault types as vibration. The vibration transducers job is to accurately and faithfully convert the vibration into an electric signal for assessment. If this part of the system is weak, reliability will be badly affected. Data integrity is crucial.

Energy Technology Data Exchange (ETDEWEB)

Manufacturers may be required to design transformers to overload specifications. Oil viscosity changes and loss variation with temperature are not accounted for in the industry loading guide. A comprehensive test program was performed using a winding assembly with imbedded thermocouples. Steady state and transient tests were performed for natural and non-directed forced oil circulation. The temperature distribution in the winding was not linear with height as usually assumed. A large number of temperature sensors is required to determine the hot spot location. The location of the hot spot was found to be different and less predictable for natural oil circulation compared with non-directed forced oil circulation especially during overload conditions. This paper reports that improved loading guide equations were developed to account for oil viscosity, resistance change, cooling duct oil rise, and location of the hot spot.

British Library Electronic Table of Contents (United Kingdom)

This work describes how a general, process-based mass-balance model (CoastMab) for phosphorus for coastal areas may be used as a tool to estimate realistic values of "natural" or preindustrial reference levels of key bioindicators in coastal science, including the Secchi depth, a standard measure of water clarity, the chlorophyll-a concentration, an operational measure of phytoplankton biomass and the concentration of cyanobacteria, a measure of the concentration of harmful algae. The CoastMab-model is an ecosystem model giving monthly predictions to achieve seasonal variations of basin-wide properties. The selected case-study area, the Gulf of Riga, is sensitive to nutrient loading because of its shallowness and low openness towards the Baltic Proper. The morphometry of any coastal area, ...

International Nuclear Information System (INIS)

A thermodynamic model for predicting the distribution coefficients has been developed by taking into account the extraction mechanism and the chloride complexation when Sm, Eu, Gd, Tb, Dy and Ho for single component systems are extracted from acidic chloride solutions by di-2-ethylhexyl ester in kerosene, respectively. The model equation includes two constants, of which one corresponds to the apparent extraction equilibrium constant and the other is due to the variation of the activity coefficients of organic species. These values are determined from a few experimental data by the curve fitting method. Then, the distribution coefficients under untried calculations, Bromley's formulation is used to estimate the activity coefficients of aqueous species and the interaction parameters for some rare earth chlorides are reported in terms of morality and molarity using data from Spedding et al. According to the authors the validity of this method has ...

International Nuclear Information System (INIS)

This paper consists of shielding analysis of steel balls and water filled end shields of Indian Pressurized Heavy Water Reactors (PHWRs). The material composition inside lattice tube is entirely different neutronically as compared with the composition of end-shield. Due to variation of material composition in radial and axial directions and complex geometry, it is necessary to carry out 3-D analysis for reasonable prediction of neutron flux and gamma dose rates. In the present paper, shielding analysis of end-shield for 540 MWe PHWR has been carried out during reactor operating and shutdown conditions using Monte-Carlo code MCNP. Furthermore materials on the periphery and central portion of end shield are different. Therefore the analysis was carried out separately for annular portion and central portion of end shield. The dominating streaming paths through end shields were studied. Predictions compare well with the ...

International Nuclear Information System (INIS)

Maps of wind resources were used to develop a method of evaluating climatic changes and their potential impacts on wind energy resources. Global IPCC climate change scenarios were used to predict climatic conditions for the future, while past wind resource availability was simulated and validated using NCEP and NCAR reanalysis data as well as observed meteorological data from Environment Canada. The simulations were used to compare each 5-year period with a 50-year reference period. Regional scale climate change impacts were evaluated using a statistical dynamic down-scaling method. Advanced meteorological models were used to predict wind flow patterns across specific landscapes. The evolution of past wind resource availability was then simulated. Five-year wind resource simulations for a 50-year period were simulated at 25 km"2 wind speeds at 80 m above the ground. Average wind speed variations were then evaluated. The ...

Science.gov (United States)

Information about surface soil moisture conditions is of critical importance to real-world applications such as agricultural production, water resource management, flood prediction, fire prediction, water supply, military mobility, etc.. Near-surface soil moisture is currently available from non-ideal sensor configuration observations, and two missions targeted at measuring near-surface soil moisture with ideal sensor configuration are expected before the end of the decade (the European Space Agency (ESA), Soil Moisture and Ocean Salinity (SMOS) mission, and the National Aeronautics and Space Administration (NASA), Hydrospheric states "Hydros" mission). Though remote sensing can make spatially comprehensive measurements of surface soil moisture, it cannot provide information on the entire land surface hydrologic system, and the measurements represent only a snap shot in time. Alternatively, land surface hydrology process models may be used to ...

UK PubMed Central (United Kingdom)

Extending genome wide association analysis by the inclusion of gene expression data may assist in the dissection of complex traits. We examined piebald, a pigmentation phenotype in both human and Merino...Full Text Available

UK PubMed Central (United Kingdom)

Synthetic gene networks can be used to control gene expression and cellular phenotypes in a variety of applications. In many instances, however, such networks can behave unreliably due to gene expression...Full Text Available

UK PubMed Central (United Kingdom)

Materials and MethodsThe genomic effects of tumor-endothelial interactions in cancer are not yet well characterized. To study this interaction in breast...Full Text Available

UK PubMed Central (United Kingdom)

Depleted uranium (DU) is a dense heavy metal used primarily in military applications. Although the health effects of occupational uranium exposure are well known, limited data exist regarding the long-term...Full Text Available

UK PubMed Central (United Kingdom)

PurposeTo date there remains no effective therapy for metastatic melanoma and at the molecular level disease progression remains poorly understood. Recent work by...Full Text Available

UK PubMed Central (United Kingdom)

The Arabidopsis ref2 mutant was identified in a screen for plants having altered fluorescence under UV light. Characterization of the ref2 mutants showed that they...Full Text Available

UK PubMed Central (United Kingdom)

The purpose of this study was to determine the occurrence and genotypic relatedness of Salmonella enterica isolates recovered from feed and fecal samples in commercial swine production...Full Text Available

UK PubMed Central (United Kingdom)

Genomic disorders are conditions that result from DNA rearrangements, such as deletions or duplications. The identification of the dosage-sensitive gene(s) within the rearranged genomic interval is...Full Text Available

UK PubMed Central (United Kingdom)

Epithelial-mesenchymal transition (EMT) has emerged in recent years as an important process in the development of organ fibrosis in many human diseases. Our previous experience in a nonhuman primate...Full Text Available

UK PubMed Central (United Kingdom)

OBJECTIVENicotinamide adenine dinucleotides (NAD⁺ and NADH) play a crucial role in cellular energy metabolism, and a dysregulated NAD⁺-to-NADH ratio is implicated...Full Text Available

UK PubMed Central (United Kingdom)

About 20% of adults are persistently colonized with S. aureus in the anterior nares. Host genetic factors could contribute susceptibility to this phenotype. The objective of...Full Text Available

UK PubMed Central (United Kingdom)

The imaging analytical capabilities of laser scanning cytometer (LSC) have been used to assess morphological features considered to be typical of the senescent phenotype. The characteristic “flattening”...Full Text Available

UK PubMed Central (United Kingdom)

Purpose: Small animal micro-CT imaging is being used increasingly in preclinical biomedical research to provide phenotypic descriptions of genomic models. Most of this imaging is coincident...Full Text Available

UK PubMed Central (United Kingdom)

Epithelial-mesenchymal transition (EMT), a switch of polarized epithelial cells to a migratory, fibroblastoid phenotype, is considered a key process driving tumor cell invasiveness and metastasis....Full Text Available

UK PubMed Central (United Kingdom)

Insulin resistance in skeletal muscle is a key phenotype associated with type 2 diabetes (T2D) for which the molecular mediators remain unclear. We therefore conducted an expression analysis of human...Full Text Available

UK PubMed Central (United Kingdom)

Stem cells of the human prostate gland have not yet been identified utilizing a structural biomarker. We have discovered a new prostatic epithelial cell phenotype-expressing cytokeratin 6a (Ck6a+...Full Text Available

UK PubMed Central (United Kingdom)

The supramammillary nucleus (SuM) provides substantial projections to the hippocampal formation. This hypothalamic structure is involved in the regulation of hippocampal theta rhythm and therefore...Full Text Available

UK PubMed Central (United Kingdom)

The genetic architecture of complex traits underlying physiology and disease in most organisms remains elusive. We still know little about the number of genes that underlie these traits, the magnitude...Full Text Available

UK PubMed Central (United Kingdom)

Gene expression data has been used in lieu of phenotype in both classical and quantitative genetic settings. These two disciplines have separate approaches to measuring and interpreting epistasis, which...Full Text Available

UK PubMed Central (United Kingdom)

BackgroundNF-κB is a survival signaling transcription factor complex involved in the malignant phenotype of many cancers, including squamous cell carcinomas (SCC). The citrus...Full Text Available

UK PubMed Central (United Kingdom)

Uncoupling protein 2 (UCP2) maps to a region on distal mouse chromosome 7 that has been linked to the phenotypes of obesity and type II diabetes. We recently reported that UCP2 expression is increased...Full Text Available

UK PubMed Central (United Kingdom)

A number of aberrant morphological phenotypes were noted during propagation of the Arabidopsis thaliana DNA hypomethylation mutant, ddm1, by repeated self-pollination. Onset of a spectrum of morphological...Full Text Available

UK PubMed Central (United Kingdom)

PurposeTo analyze the contributions of cytochrome P4501B1 (CYP1B1) mutations to primary congenital glaucoma (PCG) in Spanish patients.MethodsWe...Full Text Available

UK PubMed Central (United Kingdom)

BackgroundBlood group O has been significantly associated with increased placental malaria infection in primiparae and reduced risk of infection in multiparae in the Gambia, an area...Full Text Available

UK PubMed Central (United Kingdom)

PurposeTo detail the highly variable ocular phenotypes of a French family affected with an autosomal dominantly inherited vitreoretinopathy and to identify the disease gene.MethodsSixteen...Full Text Available

International Nuclear Information System (INIS)

Abstract only.

Energy Technology Data Exchange (ETDEWEB)

A phenomenological model of the heat transfer in direct injection diesel engines was developed. Utilizing the thermodynamic results of a combustion model as an input, the model is able to predict the temporal variation of the heat losses from the cylinder gas to the cylinder walls. Additionally, the division into isothermal combustion chamber subsurfaces allows the consideration of the spatial variation of the wall heat fluxes. The physical mechanisms such as flow dependent convection, heat radiation due to hot soot particles and isolation effects of deposited soot layers are described in detail. Thus the effects of these mechanisms on the overall heat transfer can be studied. The heat transfer model was verified successfully by the comparison to measured wall heat fluxes in a single-cylinder direct injection diesel engine. It is shown that the effects of engine speed and load, turbocharging and soot deposition can be ...

Energy Technology Data Exchange (ETDEWEB)

Shewanella oneidensis MR-1 is a model environmental organism that possesses diverse respiratory capacities, including the ability to reduce soluble Cr(VI) to sparingly soluble, less toxic Cr(III). Effective bioremediation of Cr-contaminated sites requires knowledge of the molecular mechanisms and regulation of heavy metal resistance and biotransformation by dissimilatory metal-reducing bacteria. Towards this goal, our ERSP-funded work is focused on the identification and functional analysis of genes/proteins comprising the response pathways for chromate detoxification and/or reduction. Previous transcriptomic profiling and whole-cell proteomic analyses implicated the involvement of a functionally undefined DNA-binding response regulator (SO2426) and a putative azoreductase (SO3585) in the chromate stress response of MR-1. Here we describe a detailed functional analysis of SO2426 and SO3585 in order to begin to understand the role of these proteins in the cellular response to chromate. ...

Energy Technology Data Exchange (ETDEWEB)

X-ray ablation of material from the first wall and other components of an ICF (Inertial Confinement Fusion) chamber is a major threat to the laser final optics. Material condensing on these optics after a shot may cause damage with subsequent laser shots. To ensure the successful operation of the ICF facility, removal rates must be predicted accurately. The goal for this dissertation is to develop an experimentally validated x-ray response model, with particular application to the National Ignition Facility (NIF). Accurate knowledge of the x-ray and debris emissions from ICF targets is a critical first step in the process of predicting the performance of the target chamber system. A number of 1-D numerical simulations of NIF targets have been run to characterize target output in terms of energy, angular distribution, spectrum, and pulse shape. Scaling of output characteristics with variations of both target yield and ...

Energy Technology Data Exchange (ETDEWEB)

No abstract prepared.

Science.gov (United States)

PMID:16589753

Energy Technology Data Exchange (ETDEWEB)

A thermal-resistant radiation sensing system using optical fiber has been developed. The system is for monitoring progress of chemical decontamination and able to measure the gamma-ray level in a hot solution of decontamination chemicals in situ. Our sensor head makes use of thermal-resistant NaI (T1) and it is connected to an optical fiber bundle. Scintillation photons pass from the NaI (T1) into the end of the bundle. This part of the system can withstand temperatures of over 100degC. At the far end of the optical fiber bundle, the scintillation photons are converted into fluorescent photons using a wavelength-shifting fiber. These photons are transferred to a distant photomultiplier tube through two thin transparent optical fibers. Furthermore, we propose a self-compensation technique for the dependence of scintillator sensitivity on. This compensation method is based on the correlation between temperature, sensitivity, and scintillation decay time. We have confirmed that it enables ...

International Nuclear Information System (INIS)

Yield stress elevations (#DELTA##sigma#_y) in pressure vessel steels irradiated at intermediate flux and fluence systematically decreased with increasing temperature and decreasing copper and nickel content. Lower stress relief temperature also decreased #DELTA##sigma#_y at bulk copper concentrations greater than about 0.3%. The dependence of #DELTA##sigma#_y on irradiation temperature between 260 and 316 C increased with copper and nickel content and decreased with phosphorus content. When normalized by the average #DELTA##sigma#_y, the fractional temperature dependence correlates with a simple empirical chemistry factor of copper and phosphorus. The correlation predicts data on the irradiation temperature dependence of #DELTA##sigma#_y found in the literature within a standard error of about 0.3 MPa/degree C and is consistent with current understanding of hardening mechanisms. However, questions remain about the effects at very low flux and finer scale ...

Energy Technology Data Exchange (ETDEWEB)

An experimental investigation of a humidification-dehumidification desalination (HDD) process using solar energy at the weather conditions of Suez City, Egypt, is presented. A test rig is designed and constructed to conduct this investigation under different environmental and operating conditions. The test rig consists of a solar water heater (concentrator solar collector type), solar air heater (flat plate solar collector type), humidifier tower and dehumidifier exchanger. Different variables are examined including the feed water flow rate, the air flow rate, the cooling water flow rate in the dehumidifier and the weather conditions. Comparisons between the experimental results and other published results are presented. It is found that the results of the developed mathematical model by the same authors are in good agreement with the experimental results. The tested results show that the productivity of the system is strongly affected by the saline water temperature at the inlet to ...

Energy Technology Data Exchange (ETDEWEB)

An experimental investigation of a humidification-dehumidification desalination (HDD) process using solar energy at the weather conditions of Suez City, Egypt, is presented. A test rig is designed and constructed to conduct this investigation under different environmental and operating conditions. The test rig consists of a solar water heater (concentrator solar collector type), solar air heater (flat plate solar collector type), humidifier tower and dehumidifier exchanger. Different variables are examined including the feed water flow rate, the air flow rate, the cooling water flow rate in the dehumidifier and the weather conditions. Comparisons between the experimental results and other published results are presented. It is found that the results of the developed mathematical model by the same authors are in good agreement with the experimental results. The tested results show that the productivity of the system is strongly affected by the saline water temperature at the inlet to ...

CERN Document Server

We present a fully relativistic formalism for describing neutrino-induced $\\Delta$-mediated single-pion production from nuclei. We assess the ambiguities stemming from the $\\Delta$ interactions. Variations in the cross sections of over 10% are observed, depending on whether or not magnetic-dipole dominance is assumed to extract the vector form factors. These uncertainties have a direct impact on the accuracy with which the axial-vector form factors can be extracted. Different predictions for $C_5^A(Q^2)$ induce up to 40-50% effects on the $\\Delta$-production cross sections. To describe the nucleus, we turn to a relativistic plane-wave impulse approximation (RPWIA) using realistic bound-state wave functions derived in the Hartree approximation to the $\\sigma$-$\\omega$ Walecka model. For neutrino energies larger than 1 GeV, we show that a relativistic Fermi-gas model with appropriate binding-energy correction produces comparable results as ...

Energy Technology Data Exchange (ETDEWEB)

This work presents comparative results of a numerical investigation of four possible models for the prediction of thermal performance of fixed bed storage units and their thermal design. These models includes Schumann's model, the radial dispersion model, a model that include both axial heat conduction in the fluid phase and admits thermal gradient in the solids particles and finally a two dimensional single phase model. For each of these models a computer code was written and tested to evaluate the computing time of same data and analyze any other computational problems. The tests of thermal performance included particle size, porosity, particle material, flow rate, inlet temperature and heat losses form tank walls and extremities. Dynamics behaviour of the storage units due to transient variation in either flow rate or inlet temperature was also investigated. The results presented include temperature gradients, pressure drop and heat ...

Energy Technology Data Exchange (ETDEWEB)

Pd/sub 2/Si layers produced by evaporation or sputtering onto silicon substrates were examined by high resolution electron microscopy, microdiffraction, X-ray, energy loss and Auger spectroscopy. The Si-Pd/sub 2/Si interfaces produced by evaporation were in all cases rougher and more polycrystalline than those produced by sputtering. X-ray microanalysis showed the predictable variation in palladium distribution across the interface but quantification did not produce the expected palladium-to-silicon ratios, primarily because of probe broadening and X-ray-induced fluorescence. Energy loss spectra showed plasmon energy shifts and changes in Si L edge shape due to bond formation with palladium. Auger data provided evidence for a small amount of oxygen at the Si-Pd/sub 2/Si interface. Electrical measurements of the ideality factor for Schottky barriers made from the materials produced higher values for the rougher evaporation-formed interfaces ...

Energy Technology Data Exchange (ETDEWEB)

The photoelectric absorption index, I/sub Pe/, is accepted as an accurate measurement for the description of formation lithology. The measured I/sub Pe/ has been shown to deviate slightly for a given lithology because of the effects of porosity. Properly calibrated and measured I/sub Pe/'s, however, have been observed to deviate from predicted values in practice, even considering the influence of porosity. Such departures were traced to variations in borehole size and tool standoff. The nature of the physical method of recording an I/sub Pe/ does not ensure independence from the influence of the borehole environment. A series of laboratory experiments has been conducted in test formations to verify and to characterize the influence of borehole size, mudcake, and standoff on I/sub Pe/ measurement. A set of nomographs has been constructed that allows correction of I/sub Pe/ measurements for the influence of the borehole environment. With ...

International Nuclear Information System (INIS)

The weldability and high temperature strength properties of tungsten-inert-gas (TIG) weldments of Hastelloy alloy XR were investigated by using two different heats of filler metals; the first (HXRF1) was designed on the basis of multiple regression analysis; the second (HXRF2) was the reference material. Bend tests, the FISCO cracking test and optical metallography were used to evaluate weldability. Tensile and creep tests were performed at 900deg C to evaluate high temperature strength properties. The results of weldability tests for both alloys showed good performance. The tensile properties of the weldments were remarkably improved in particular with respect to high temperature ductility. The creep rupture strength in the weldments made with alloy-designed HXRF1 was much higher than those of the Hastelloy alloy XR-II base metal with a higher B content. Furthermore, the creep properties were stable with respect to variations in welding conditions. Since the ...

Energy Technology Data Exchange (ETDEWEB)

The flux of cosmic ray antiprotons with kinetic energies between /approximately/1 and 15 GeV is /approximately/5 times greater than the flux predicted on the basis of the leaky-box model. This excess is attributed to secondary antineutron production in compact sources. Because the antineutrons are not confined by the magnetic field of the compact source, they leave the interaction site, decay in interstellar space and account for the apparent excess cosmic ray antiproton flux. The escape and decay of neutrons produced in association with the antineutrons is a source of cosmic ray protons. Observations of the angular variation of the intensity and spectral shape of 100 MeV ..gamma..-rays produced by neutron-decay protons in the reaction p + p ..-->.. ..pi../sup 0/ ..-->.. 2..gamma.. could reveal compact-source cosmic ray production sites. COS-B observations of spectral hardening near point sources, and future high-resolution observations ...

Energy Technology Data Exchange (ETDEWEB)

The accurate prediction of local hot spot during normal operation is important to ensure core thermal margin in a very high temperature gas-cooled reactor because of production of its high temperature output. The active cooling of the reactor core determining local hot spot is strongly affected by core bypass flows through the inter-column gaps between graphite blocks and the cross gaps between two stacked fuel blocks. The bypass gap sizes vary during core life cycle by the thermal expansion at the elevated temperature and the shrinkage/swelling by fast neutron irradiation. This study is to investigate the impacts of the variation of bypass gaps during core life cycle as well as core restraint mechanism on the amount of bypass flow and thus maximum fuel temperature. The core thermo fluid analysis is performed using the GAMMA+ code for the PMR200 block-core design. For the analysis not only are some modeling features, developed for solid ...

Energy Technology Data Exchange (ETDEWEB)

The relationship between coal properties and liquefaction or gasification characteristics was analyzed by using the analysis and test results and liquefaction characteristics in the coal data base. On liquefaction reaction, the close relation between an oil yield and coal constituent composition or a coal rank is well-known. Various multivariable regression analyses were conducted by using 6 factors as variables such as calorific value, volatile component, O/C and H/C atomic ratios, exinite+vitrinite content and vitrinite reflectance, and liquefaction characteristics as variate. On liquefaction characteristics, the oil yield of dehydrated and deashed coals, asphaltene yield, hydrogen consumption, produced water and gas quantities, and oil+asphaltene yield were predicted. The theoretical gasification efficiency of each specimen was calculated to evaluate the liquefaction reaction obtained. As a result, the oil yield increased with H/C atomic ...

Energy Technology Data Exchange (ETDEWEB)

The deactivation rate of a resid hydrotreating catalyst is determined by a complex set of factors involving both chemical and physical changes in the catalyst structure. The various chemical changes that are associated with resid conversion involve thermal and catalytic steps of relatively large molecular weight species with the overall rates significantly affected by mass transfer limitations. The deposition of coke and the variation in the effective promoter level by the accumulation of metals deposited from the resid are the principal factors governing deactivation. The relative importance of mass transfer restrictions on activity and catalyst deactivation can be observed in studies where the average pore diameter of the catalyst has been varied. Several models have been proposed to characterize the deactivation of resid hydroprocessing catalysts. In this paper, the authors discuss some accelerated aging tests with a relatively large pore commercial ...

Science.gov (United States)

Multiple treatment of engineering surfaces can provide improved surface properties that cannot be obtained by a single surface treatment. Consequently, this study investigates the effects of laser melting on the microstructures of plasma nitrided Ti-6Al-4V alloy. The study consists of two parts. In the first part, governing equations pertinent to the laser melting process are developed, and temperature variation across the melted zone is predicted. In the second, an experiment is conducted to nitride the surface of the alloy through plasma nitriding process and to melt the plasma nitrided and the untreated alloy surfaces with a CO2 laser beam. The resulting metallurgical changes are examined using x-ray diffraction (XRD), bdenergy-dispersive spectrometry (EDS), and scanning electron microscopy (SEM) techniques. It is shown that three distinct nitride layers are formed in the vicinity of the alloy surface prior to the laser melting process, and ...

Energy Technology Data Exchange (ETDEWEB)

A brief review and assessment of field measurement programs that provide data for mixed layer diffusion research is presented. The majority of programs emphasize either the meteorological aspects of the mixed layer or plume characterization. Few programs are available that provide the complimentary blend of plume and appropriate meteorological measurements needed to adequately validate mixed layer diffusion theory. Three major U.S. EPA (Environmental Protection Agency) field programs that provide data bases for model development and validation of mixed layer diffusion processes are described and discussed in more detail. The Regional Air Pollution Study (RAPS) focused on measurements of surface and mixed layer turbulent transport processes in the urban environment. The Tennessee Plume Study (TPS) obtained a database with coincident measurement of boundary layer turbulent structure and plume dispersion for a large coal-fired power plant in nonuniform terrain over the diurnal cycle. The ...

Energy Technology Data Exchange (ETDEWEB)

Damage and cyclic fatigue failure under alternating loading in transformation-toughened zirconia ceramics is reviewed and compared to corresponding behavior under quasi-static loading (static fatigue). Current understanding of the role of transformation toughening in influencing cyclic fatigue-crack propagation behavior is examined based on studies which altered the extent of the tetragonal-to-monoclinic phase transformation in MG-PSZ through subeutectoid aging. These studies suggest that near-tip computations of the crack-driving force (in terms of the local stress intensity) can be used to predict crack-growth behavior under constant amplitude and variable-amplitude (spectrum) loading, using spatially resolved Raman spectroscopy to measure the extent of the transformation zones. In addition, results are reviewed which rationalize distinctions between the crack-growth behavior of preexisting, long'' (> 2 mm), through-thickness cracks and ...

UK PubMed Central (United Kingdom)

BackgroundRecently, the discovery of copy number variation (CNV) led researchers to think that there are more variations of genomic DNA than initially believed. Moreover, a certain...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

This document consist of brief reports prepared by postdoctoral students supported by the project, each describing his accomplishments under the grant. Topics include (1) Malignant Transformation of MSU-1. 1 Cells by Gamma Radiation, (2) Correlation between Levels of ras Expression and Presence of Transformed Phenotypes Including Tumorigenicity, Using a Modulatable Promoter, (3) Relation between Specific rad Oncogene Expression, (4) Correlation of Genetic Changes in Fibroblastic Tumors with Malignancies, (5)Transformation of MSU-1.1 Cells by sis Oncogene, (6) Malignant Transformation of MSU-1.0 Cells, (7) Correlation of Urokinase Plasminogen Activation (mu-PA) with Malignant Phenotype, (8)Two Dimensional Gel Electrophoresis Studies of the Proteins of the Major Cell Strains of the MSU-1 Family of Cells, and (9) Correlation between Proteinase Activity Levels and Malignancy.

British Library Electronic Table of Contents (United Kingdom)

Abstract Gelatinization temperature (GT) is an important parameter in evaluating the cooking and eating quality of rice. Indeed, the phenotype, biochemistry and inheritance of GT have been widely studied in recent times. Previous map-based cloning revealed that GT was controlled by ALK gene, which encodes a putative soluble starch synthase II-3. Complementation vector and RNAi vector were constructed and transformed into Nipponbare mediated by Agrobacterium. Phenotypic and molecular analyses of transgenic lines provided direct evidence for ALK as a key gene for GT. Meanwhile, amylose content, gel consistency and pasting properties were also affected in transgenic lines. Two of four nonsynonymous single nucleotide polymorphisms in coding sequence of ALK were identified as essential for GT. ...

UK PubMed Central (United Kingdom)

Sensory systems must form stable representations of the external environment in the presence of self-induced variations in sensory signals. It is also possible that the variations themselves may provide...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

The authors solve the instability of perturbative vacuum of Gross-Neveu model. They use a variational method. The analysis is nonperturbative as it uses only equal time commmutator/anticommutator algebra.

Energy Technology Data Exchange (ETDEWEB)

This paper presents a mathematical model that calculates eddy current signals from laterally spaced transmit-receive pancake coils. This model was validated by comparing calculations with laboratory measurements and it has been applied to evaluating design variations in X-Probe eddy current array coils. This model was used to quantify detection capabilities of probe designs with different numbers of coils. The current standard X-Probe design for 13 mm (0.5 inch) diameter steam generator tubes uses 3 rows of coils with 8 coils per row. This design is commonly referred to as the '8 coil X-Probe'. A significant improvement in detection capability was predicted for an X-Probe with 12 coils per row (called the '12 coil X-Probe') detecting short circumferential crack-like flaws. Based on these calculations, a prototype 12 coil X-Probe was constructed and used in laboratory measurements in comparison with a standard ...

International Nuclear Information System (INIS)

The structural transition and anomalous properties of the high temperature A-15 superconductors have been investigated from two different standpoints. The first is a Landau theory based on Gorkov's physical model of a Peierls-like charge density wave (CDW) transition involving electronic CDW order parameters coupled to phonon coordinates. Pretransition elastic anomalies, softening of the [1 anti 10] transverse ([1 anti 10] polarized) phonon, sublattice distortions, variation of transition temperature with stress and alloying and other effects have been accurately predicted, and a detailed comparison is made with experimental results. Central peaks in neutron scattering are shown to be non-dynamic in nature and no pretransition forbidden (300) reflection is predicted. The GAMMA_1_2 optic mode does not go soft at the transition, though its frequency is expected to be temperature dependent right up to room temperature. A tight ...

UK PubMed Central (United Kingdom)

The deregulated kinase activity of p210-BCR/ABL oncoproteins, hallmark of chronic myelogenous leukaemia (CML), induces and sustains the leukaemic phenotype, and contributes to disease progression....Full Text Available

UK PubMed Central (United Kingdom)

BackgroundEstrogen receptors alpha (ERα) and beta (ERβ) are transcription factors (TFs) that mediate estrogen signaling and define the hormone-responsive phenotype...Full Text Available

UK PubMed Central (United Kingdom)

PurposeTo describe clinical data and to characterize mutations in the transforming growth factor beta-induced (TGFBI) gene in patients from three unrelated Chilean...Full Text Available

UK PubMed Central (United Kingdom)

Loss-of-function mutations in the regulatory gene areA of Aspergillus nidulans prevent the utilization of a wide variety of nitrogen sources. The phenotypes of nit-2 mutants of Neurospora crassa suggest...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

A crucial step in human breast cancer progression is the acquisition of invasiveness. There is a distinct lack of human cell culture models to study the transition from pre-invasive to invasive phenotype as it may occur 'spontaneously' in vivo. To delineate molecular alterations important for this transition, we isolated human breast epithelial cell lines that showed partial loss of tissue polarity in three-dimensional reconstituted-basement membrane cultures. These cells remained non-invasive; however, unlike their non-malignant counterparts, they exhibited a high propensity to acquire invasiveness through basement membrane in culture. The genomic aberrations and gene expression profiles of the cells in this model showed a high degree of similarity to primary breast tumor profiles. The xenograft tumors formed by the cell lines in three different microenvironments in nude mice displayed metaplastic phenotypes, including ...

KoreaScience (Korea)

Full Text Available

Science.gov (United States)

Not Available

KoreaScience (Korea)

Full Text Available

Energy Technology Data Exchange (ETDEWEB)

No abstract prepared.

KoreaScience (Korea)

Full Text Available

KoreaScience (Korea)

Full Text Available

KoreaScience (Korea)

Full Text Available

International Nuclear Information System (INIS)

The general development of variational methods for fusion reactor blanket studies is given. Important quantities such as tritium breeding ratio and total nuclear heating are linear functionals of the solutions to the Boltzmann transport equation. To estimate a neutronic quantity by variational methods is, in general, to carry out the scalar product formulation of the Roussopoulos variational principle, or the Schwinger variational principle, with the help of the associated adjoint transport equation where the appropriate response function for the estimate is taken as the source. A multipoint interpolation method based on the above variational principles has been developed and compared to other variational approaches. The method of variational interpolation removes the need to compute both forward and adjoint solutions while the error has the ...

Energy Technology Data Exchange (ETDEWEB)

The paper considers the cyclic variations in performance parameters of a dual fuel engine fuelled with methane. It is shown that such an engine does display cyclic variations that are greater than the corresponding diesel operation, yet smaller than comparable spark ignition operation. The extent of cyclic variation in peak cylinder pressure and ignition delay increases, for any power output, as the pilot diesel quantity is reduced and the extent of gas substitution is increased. The use of extremely small pilots in the unmodified engine can lead to erratic engine performance. Greater cyclic variations are associated with low lead rather than high load operation.

KoreaScience (Korea)

Full Text Available

Science.gov (United States)

Not Available

International Nuclear Information System (INIS)

We have performed self-consistent (SC) band structure calculations for the A15 compounds V_3X and Nb_3X, X = Al, Ga, Si, Ge, and Sn, using the augmented-plane-wave (APW) method. Relativistic effects (except the spin-orbit interaction) have been included in each SC cycle, along with corrections to the usual muffin-tin approximation. The latter apply the APW wave functions outside of the muffin-tin spheres to compute the interstitial charge densities and potentials. The resulting interstitial potential has full cubic symmetry (no spherical averaging), although a spherically averaged muffin-tin form is retained inside the spheres. The final SC potentials were used to generate energies and wave functions on a cubic mesh of 35 k points in 1/48th of the Brillouin zone. These results were interpolated onto a finer mesh of 969 k points using a symmetrized Fourier method; the densities of states (DOS), N (E), were determined using tetrahedral integration. These accurate interpolation methods ...

Energy Technology Data Exchange (ETDEWEB)

This report describes the results made in fulfillment of contract DE-FG26-02NT15451, ''Multicomponent Seismic Analysis and Calibration to Improve Recovery from Algal Mounds: Application to the Roadrunner/Towaoc Area of the Paradox Basin, Ute Mountain Ute Reservation, Colorado''. Optimizing development of highly heterogeneous reservoirs where porosity and permeability vary in unpredictable ways due to facies variations can be challenging. An important example of this is in the algal mounds of the Lower and Upper Ismay reservoirs of the Paradox Basin in Utah and Colorado. It is nearly impossible to develop a forward predictive model to delineate regions of better reservoir development, and so enhanced recovery processes must be selected and designed based upon data that can quantitatively or qualitatively distinguish regions of good or bad reservoir permeability and porosity between existing well control. ...

Energy Technology Data Exchange (ETDEWEB)

Three normal human diploid cell strains were transfected with an activated Ha-ras oncogene (EJ ras) or SV40 T-antigen. Multiple clones were examined for morphological alterations, growth requirements, ability to grow under anchorage independent conditions, immortality and tumorigenicity in nude mice. Clones expressing SV40 T-antigen alone or in combination with ras protein p21 were significantly radioresistant as compared with their parent cells or clones transfected with the neo gene only. This radioresistant phenotype persisted in post-crisis, immortalized cell lines. These data suggest that expression of the SV40 T-antigen but not activated Ha-ras plays an important role in the radiosensitivity of human diploid cells. The radioresistant phenotype in SV40 T transfected cells was not related to the enhanced level of genetic instability seen in pre-crisis and newly immortalized cells, nor to the process of immortalization itself. (author).

Energy Technology Data Exchange (ETDEWEB)

We investigated the in vitro phenotypic transformation of human embryo (HE) cells that were repeatedly irradiated (7.5 cGy once a week) throughout their life-span. Irradiation was repeated until the cells had accumulated 195 cGy (equivalent to the 26th passage). Samples of cells were assayed for survival by colony formation, as well as for mutation at the hypoxanthine guanine phosphoribosyl transferase (HGPRT) locus and for transformation by focus formation. The life-span (mean number of population doublings) of multiply irradiated cells with a total dose of 97.5 cGy was slightly but significantly prolonged over that of controls. After HE cells had accumulated 195 cGy, the maximum number of divisions increased to 130-160% of the number in non-irradiated control cells. Transformed foci were not observed until cells had accumulated 97.5 cGy, and then increased with the increasing accumulation of radiation. However, no cells showed immortality or expressed a malignant ...

Energy Technology Data Exchange (ETDEWEB)

The classical phenomenon of position-effect variegation (PEV) is the mosaic expression that occurs when a chromosomal rearrangements moves a euchromatic gene near heterochromatin. A striking feature of this phenomenon is that genes far away from the junction with heterochromatin can be affected, as if the heterochromatic state {open_quotes}spreads.{close_quotes} We have investigated classical PEV of a Drosophila brown transgene affected by a heterochromatic junction {approximately} 60 kb away. PEV was enhanced when the transgene was locally duplicated using P transposase. Successive rounds of P transpose mutagenesis and phenotypic selection produced a series of PEV alleles with differences in phenotype that depended on transgene copy number and orientation. As for other examples of classical PEV, nearby heterochromatin was required for gene silencing. Modifications of classical PEV by alterations at a single site are unexpected, and these ...

Energy Technology Data Exchange (ETDEWEB)

Attention deficit disorder (ADHD) is a complex biobehavioral phenotype which affects up to 8% of the general population and often impairs social, academic, and job performance. Its origins are heterogeneous, but a significant genetic component is suggested by family and twin studies. The murine strain, coloboma, displays a spontaneously hyperactive phenotype that is responsive to dextroamphetamine and has been proposed as a genetic model for ADHD. Coloboma is a semi-dominant mutation that is caused by a hemizygous deletion of the SNAP-25 and other genes on mouse chromosome 2q. To test the possibility that the human homolog of the mouse coloboma gene(s) could be responsible for ADHD, we have carried out linkage studies with polymorphic markers in the region syntenic to coloboma (20p11-p12). Five families in which the pattern of inheritance of ADHD appears to be autosomal dominant were studied. Segregation analysis of the traits studied suggested ...

UK PubMed Central (United Kingdom)

It has been suggested for quality assurance purposes that linac output variations for helical tomotherapy (HT) be within ±2% of the long-term average. Due to cancellation of systematic...Full Text Available

UK PubMed Central (United Kingdom)

Electrophoretic analysis of protein variation at the coagulation F13B locus has previously revealed three alleles, with alleles 1, 2, and 3 each being at high frequency in European,...Full Text Available

UK PubMed Central (United Kingdom)

Background and AimsVariation in mating patterns may be particularly evident in colonizing species because they commonly experience wide variation in plant density. Here, the role...Full Text Available

UK PubMed Central (United Kingdom)

A remarkable range of variation has been demonstrated in the biting habits of A. darlingi in South America. At the centre of its area of distribution, the species comprises both anthropo-endophilic...Full Text Available

UK PubMed Central (United Kingdom)

Inherited genetic variation has a critical but as yet largely uncharacterized role in human disease. Here we report a public database of common variation in the human genome: more than one million...Full Text Available

International Nuclear Information System (INIS)

Inherent to helical tomotherapy is a dose variation pattern that manifests as a 'ripple' (peak-to-trough relative to the average). This ripple is the result of helical beam junctioning, completely unique to helical tomotherapy. Pitch is defined as in helical CT, the couch travel distance for a complete gantry rotation relative to the axial beam width at the axis of rotation. Without scattering or beam divergence, an analytical posing of the problem as a simple integral predicts minima near a pitch of 1/n where n is an integer. A convolution-superposition dose calculator (TomoTherapy, Inc.) included all the physics needed to explore the ripple magnitude versus pitch and beam width. The results of the dose calculator and some benchmark measurements demonstrate that the ripple has sharp minima near p=0.86(1/n). The 0.86 factor is empirical and caused by a beam junctioning of the off-axis dose profiles which differ from the axial profiles as well ...

International Nuclear Information System (INIS)

Developed under the PN II Project 71-009 - MONA, the pre-operational monitoring program of the LIL waste disposal site presented in this paper covers the main elements requested for a continuous improvement of site characterization and safety assessment, as well as for the set up of the baseline data requested for the future operational and post-operational monitoring and surveillance. These elements are: vadose and saturated zones hydrogeology, surface erosion, meteorology and radionuclides content in waters, soil and biota. Pairs of TDR (Time Domain Reflectometry) and pressure sensors, coupled with a meteorological station have been installed on site for the continuously measurement of the water content and matric potential changes due to the climate variations. The data will be used to follow the water balance, the pores water velocity and to calculate the infiltration rate. A new set of erosion rates experimentally determined by Pinhole test on surface soil ...

Energy Technology Data Exchange (ETDEWEB)

A procedure is described for modeling the choices made in urban American households among personal vehicles on the bases of cost, passenger capacity, and engine technology, and it projects those preferences to the year 1990 and 2000. The results of this disaggregate technique are used by the other predictive research tasks undertaken by Argonne National Laboratory in a project entitled Technology Assessment of Productive Conservation in Urban Transportation (TAPCUT). The vehicle preferences reported here furnish data for the overall TAPCUT objective of forecasting the probable effects of energy conservation policies in transportation. In our projections, vehicles with standard spark-ignition (Otto-cycle) engines continue to dominate automobile holdings and new car purchases in either of two socioeconomic scenarios under any of three settings (an existing policy set and two alternative conservation strategies). From 1990, small cars (seating four or fewer ...

Energy Technology Data Exchange (ETDEWEB)

A numerical simulation of two-dimensional laminar natural convection in a fully open tilted square cavity with an isothermally heated back wall is conducted. The remaining two walls of the cavity are adiabatic. Steady-state solutions are presented for Grashof numbers between 10{sup 2} and 10{sup 5} and for tilt angles ranging from {minus}60{degree} to 90{degree} (where 90{degree} represents a cavity with the opening facing down). The fluid properties are assumed to be constant except for the density variation with temperature that gives rise to the buoyancy forces, which is treated by the Boussinesq approximation. The fluid concerned is air with Prandtl number fixed at 0.71. The governing equations are expressed in a normalized primitive variables formulation. Numerical predictions of the velocity and temperature fields are obtained using the finite-volume-based power law (SIMPLER: Semi-Implicit Method for Pressure-Linked Equations Revised) ...

International Nuclear Information System (INIS)

Ferrofluids have promising potential for heat transfer applications, since advective transport in a ferrofluid can be readily controlled by using an external magnetic field. However, unlike conventional free or forced convection, ferrohydrodynamic convection is not yet well characterized. A full understanding of the relationship between an imposed magnetic field, the resulting ferrofluid flow, and the temperature distribution is a prerequisite for the proper design and implementation of applications involving thermomagnetic convection. The literature variously assumes constant magnetic fields, does not completely represent the variation in the imposed field, or its descriptions are inaccurate, since the fields do not comply with the Maxwell's equations of electromagnetism. We address this by simulating two-dimensional forced convection heat transfer in a channel with a ferrofluid that is under the influence of a two-dimensional magnetic field created by a ...

Science.gov (United States)

Adsorption of ethylene and ethane on graphitized thermal carbon black and in slit pores whose walls are composed of graphene layers is studied in detail to investigate the packing efficiency, the two-dimensional critical temperature, and the variation of the isosteric heat of adsorption with loading and temperature. Here we used a Monte Carlo simulation method with a grand canonical Monte Carlo ensemble. A number of two-center Lennard-Jones (LJ) potential models are investigated to study the impact of the choice of potential models in the description of adsorption behavior. We chose two 2C-LJ potential models in our investigation of the (i) UA-TraPPE-LJ model of Martin and Siepmann for ethane and Wick et al. for ethylene and (ii) AUA4-LJ model of Ungerer et al. for ethane and Bourasseau et al. for ethylene. These models are used to study the adsorption of ethane and ethylene on graphitized thermal carbon black. It is found that the solid-fluid binary interaction ...

Energy Technology Data Exchange (ETDEWEB)

Land surface parameterization schemes such as the Simple Biosphere Model (SiB2) have found considerable use in climate simulation models, where they provide lower boundary conditions in the form of surface sensible and latent heat fluxes. A methodology is described to apply models of this type at high resolution, using data from the Department of Energy{close_quote}s Cloud and Radiation Testbed in Oklahoma and Kansas, to determine the spatial variations of heat fluxes over the domain and to determine area-weighted flux averages for use in single-column model studies. Data from a dense array of meteorological instruments are interpolated to provide the wind, temperature, vapor pressure, radiation, and precipitation values needed by SiB2. The state of the vegetation is characterized through the use of the normalized difference vegetation index determined from satellites. The performance of the SiB2 model is evaluated by comparing its predictions ...

KoreaScience (Korea)

Full Text Available

International Nuclear Information System (INIS)

Calculating the local spectral densities at magnetic adatoms, we estimate the variation in the Yosida-Kondo resonance due to the Ruderman-Kittel-Kasuya-Yosida (RKKY) interaction and the direct exchange between adatoms in systems of magnetic trimers on metal surfaces. The results show that the RKKY interaction leads to the gradual variation in Kondo temperature, and the direct exchange can be the origin of the drastic variation. (author)

UK PubMed Central (United Kingdom)

Computational prediction of microRNA targets remains a challenging problem. The existing rule-based, data-driven and expression profiling approaches to target prediction are mostly approached from the...Full Text Available

Science.gov (United States)

... Title : The Numerical Weather Prediction System at the Italian Air Force Weather Service: Impact of Non-Conventional Observations and Increased ...

Science.gov (United States)

Brush fires, especially during the summer months, are hazards that occasionally threaten the leeward (Waianae) coast of Oahu in Hawaii. The prediction of future ... ...

Science.gov (United States)

... This paper presents our research in neural learning for predicting ... Denote this feature set as F4. ... can be observed that the SOC curves generated by ...

Energy Technology Data Exchange (ETDEWEB)

The purpose of this study was to evaluate the ability to enhance distribution of eelgrass (Zostera marina) in the Columbia River Estuary to serve as refuge and feeding habitat for juvenile salmon, Dungeness crab, and other fish and wildlife. We strongly suspected that limited eelgrass seed dispersal has resulted in the present distribution of eelgrass meadows, and that there are other suitable places for eelgrass to survive and form functional meadows. Funded as part of the Bonneville Power Administration's call for Innovative Projects, we initiated a multistage study in 2008 that combined modeling, remote sensing, and field experimentation to: (1) Spatially predict habitat quality for eelgrass; (2) Conduct experimental plantings; and (3) Evaluate restoration potential. Baseline in-situ measurements and remote satellite observations were acquired for locations in the Lower Columbia River Estuary (LCRE) to determine ambient habitat conditions. These were ...

Energy Technology Data Exchange (ETDEWEB)

The development of attenuated response ({open_quotes}tolerance{close_quotes}) to daily ozone (O{sub 3}) exposures in the laboratory is well established in healthy adult volunteers. However, the capability of asthmatics to develop tolerance during multiday ozone exposures in unclear. We exposed 10 adult volunteers with mild asthma to 0.4 ppm O{sub 3} in filtered air for 3 h/d on 5 consecutive d. Two similar filtered-air exposures during the preceding week served as controls. Follow-up O{sub 3} exposures were performed 4 and 7 d after the most recent consecutive exposure. All exposures were performed in an environmental chamber at 31 {degrees}C and 35% relative humidity. The subjects performed moderate exercise (mean ventilation rate of 32 l/min) for 15 min of each half-hour. Responses were measured with spirometry and symptom evaluations before and after each exposure, and a bronchial reactivity test (methacholine challenge) was conducted after each exposure. All response measurements ...

KoreaScience (Korea)

Full Text Available

International Nuclear Information System (INIS)

... p. SPECIFIC NUCLEAR REACTORS AND ASSOCIATED PLANTS algorithms

KoreaScience (Korea)

Full Text Available

Science.gov (United States)

... predicting potential increases in human mortality due to global warming....

Science.gov (United States)

Not Available

Science.gov (United States)

Not Available

KoreaScience (Korea)

Full Text Available

KoreaScience (Korea)

Full Text Available

KoreaScience (Korea)

Full Text Available

Energy Technology Data Exchange (ETDEWEB)

This report is intended to satisfy two concurrent needs: (1) provide a contract deliverable from Oncorh Consulting to the Washington Department of Fish and Wildlife (WDFW), with emphasis on identification of salient results of value to ongoing Yakima/Klickitat Fisheries Project (YKFP) planning and (2) summarize results of research that have broader scientific relevance. This is the fourth in a series of reports that address reproductive ecological research and monitoring of spring chinook populations in the Yakima River basin. This annual report summarizes data collected between April 1, 2004 and March 31, 2005 and includes analyses of historical baseline data, as well. Supplementation success in the Yakima Klickitat Fishery Project's (YKFP) spring chinook (Oncorhynchus tshawytscha) program is defined as increasing natural production and harvest opportunities, while keeping adverse ecological interactions and genetic impacts within acceptable bounds (Busack et al. 1997). ...

International Nuclear Information System (INIS)

The effect of variations of the fundamental constants on the thermonuclear rate of the triple alpha reaction, "4He(#alpha##alpha#, #gamma#)"1"2C, that bridges the gap between "4He and "1"2C is investigated. We have followed the evolution of 15 and 60 M#centre dot# zero metallicity stellar models, up to the end of core helium burning. They are assumed to be representative of the first (Population III) stars. The calculated oxygen carbon abundances resulting from helium burning can then be used to constrain the variation of the fundamental constants.

Science.gov (United States)

The formation mechanism of the cold-rolled strip shape with high tension was studied. An advanced method to calculate the allowable variation of strip transverse profiles was established by the strip buckling criterion, which can be more properly used in cold rolling. With this method, the aim allowable variation of the product strip transverse profile and the required transverse profile range of incoming strips can be reached. Besides, this method has been successfully applied in a domestic tandem cold mill, and the transverse profile range of incoming strips suggested with this method is more practicable and complete. Consequently, the good performance is acquired.

British Library Electronic Table of Contents (United Kingdom)

Malformations in farmed fish are a prime research topic as it has a major impact on fish welfare and on the economical value of the product. In this study, the genetic component of spine deformities was estimated in European sea bass, a major species of Mediterranean aquaculture, with the use of a posteriori reconstruction of pedigree with microsatellites. Our population exhibited a very high malformation rate (81%), probably due to intense swimming of fish during pre-growing. The heritability of global spine deformities was evaluated to be 0.21?0.04 on the underlying scale (0.33?0.06 for lordosis, 0.13?0.04 for scoliosis). Deformities scored by an internal or external examination turned out to be genetically the same trait (genetic correlations>0.9), although phenotypic correlations were ...

Science.gov (United States)

Exponentially growing biological and bioinformatics data sets present a challenge and an opportunity for researchers to contribute to the understanding of the genetic basis of phenotypes. Due to breakthroughs in microarray technology, it is possible to simultaneously monitor the expressions of thousands of genes, and it is imperative that researchers have access to the clinical data to understand the genetics and proteomics of the diseased tissue. This technology could be a landmark in personalized medicine, which will provide storage for clinical and genetic data in electronic health records (EHRs). In this paper, we explore the computational and ethical challenges that emanate from the intersection of bioinformatics and healthcare informatics research. We describe the current situation of the EHR and its capabilities to store clinical and genetic data and then discuss the Genetic Information Nondiscrimination Act. Finally, we posit that the synergy obtained from ...

British Library Electronic Table of Contents (United Kingdom)

Severe affective and behavioral dysregulation, labeled as severe mood dysregulation (SMD), is a widely spread phenomenon among adolescent psychiatric patients. This phenotype constitutes severe impairment across multiple settings, including various symptoms, such as non-episodic anger, mood instability, and hyperarousal. Moreover, SMD patients often show depression and reduced need for sleep. Despite a lifetime prevalence of 3.3%, systematic research is still scarce, and treatments that have been established do not account for the range of symptoms present in SMD. Considering the circadian dysfunctions, two hormones, melatonin and cortisol, are essential. When these hormones are dysregulated, the circadian rhythm gets out of synchrony. Since evidence is emerging showing that the worse the ...

British Library Electronic Table of Contents (United Kingdom)

Abstract Tumor necrosis factor (TNF)- is a pro-inflammatory cytokine associated with psoriasis pathogenesis. Anti-TNF- therapies are effective in psoriasis. A significant weight gain has been reported in patients treated with anti-TNF- agents. The aim of the present study was to evaluate the body composition changes in psoriatic patients receiving anti-TNF- therapies according with disease phenotype. Forty patients affected with psoriasis were followed up for 24 weeks and divided into two groups: psoriasis vulgaris (PsO) and psoriatic arthritis (PsA). Anthropometric, blood biochemical, body composition parameters, resting metabolic rate, and disease activity indexes were measured at baseline and at week 24. After 24 weeks of anti-TNF- administration, the disease activity indexes and concen...

British Library Electronic Table of Contents (United Kingdom)

Abstract A method to grow the halophilic archaeon Haloferax volcanii in microtiter plates has been optimized and now allows the parallel generation of very reproducible growth curves. The doubling time in a synthetic medium with glucose is around 6-h. The method was used to optimize glucose and casamino acid concentrations, to clarify carbon source usage and to analyze vitamin dependence. The characterization of osmotolerance revealed that after a lag phase of 24-h, H. volcanii is able to grow at salt concentrations as low as 0.7-M NaCl, much lower than the 1.4-M NaCl described as the lowest concentration until now. The application of oxidative stresses showed that H. volcanii exhibits a reaction to paraquat that is delayed by about 10-h. Surprisingly, only one of two amino acid auxotrophi...

International Nuclear Information System (INIS)

The authors have shown that toxicity of paraquat for Escherichia coli is increased over 1-fold in strains defective in the biosynthesis of spermidine compared to isogenic strains containing spermidine. The increased sensitivity of these spermidine-deficient mutants to paraquat is eliminated by growth in medium containing spermidine or by endogenous supplementation of spermidine by the use of a speE"+D"+ plasmid. No paraquat toxicity is seen in the absence of oxygen, even in amine-deficient strains, indicating that superoxide is the agent responsible for the increased toxicity. However, the specific mechanisms responsible for the increased paraquat toxicity in the spermidine-deficient mutants remain to be determined. The marked sensitivity to paraquat of E. coli deficient in spermidine is of particular interest, since such mutants have no other phenotypic properties that can be easily assayed. This increased sensitivity has been used as the basis of a convenient ...

British Library Electronic Table of Contents (United Kingdom)

Objective: Evidence from adults suggests that changes in thyroid function are associated with the development of bipolar disorder (BD) and severe mood dysregulation. A dysregulation profile based on the Child Behavior Checklist (CBCL-DP) describes a phenotype with severe mood problems in youth. The present study investigated whether altered thyroid functioning in youths is associated with the severe mood dysregulation symptoms characterized by the CBCL-DP. Methods: We analyzed the thyroid function data from 262 children and adolescents (n=262 for serum TSH, n=148 for free triiodothyronine [fT3] and n=153 for free thyroxine [fT4]) with their CBCL-DP composite score. We created and compared high CBCL-DP and low CBCL-DP subgroups with regard to their serum TSH, fT3 and fT4 concentrations as w...

British Library Electronic Table of Contents (United Kingdom)

Fibroblast growth factor (FGF) signaling has been shown to regulate lung epithelial development but its influence on mesenchymal differentiation has been poorly investigated. To study the role of mesenchymal FGF signaling in the differentiation of the mesenchyme and its impact on epithelial morphogenesis, we took advantage of Fgfr2c+/? mice, which due to a splicing switch express Fgfr2b in mesenchymal tissues and manifest Apert syndrome-like phenotypes. Using a set of in vivo and in vitro studies, we show that an autocrine FGF10?FGFR2b signaling loop is established in the mutant lung mesenchyme, which has several consequences. It prevents the entry of the smooth muscle progenitors into the smooth muscle cell (SMC) lineage and results in reduced fibronectin and elastin deposition. Levels of...

International Nuclear Information System (INIS)

Increased levels of epidermal growth factor receptor have been reported in a variety of tumors, including pulmonary squamous cell carcinomas in man. The purpose of this study was to determine if increased levels of epidermal growth factor (EGFR) were present in lung tumors from Beagle dogs that had been exposed to "2"3"9PuO_2- Using immunohistochemical techniques, sections from 17 lung tumors were examined for the presence of EGFR. Seven of the tumors were strongly positive for EGFR; the remainder of the tumors and the normal lung sections were negative. The positive immunostaining could not be correlated with the histologic phenotype of the tumors. Work is in progress to determine the level of EGFR in preneoplastic, proliferative epithelial foci in the Iung. (author)

British Library Electronic Table of Contents (United Kingdom)

Optimization of nonviral gene delivery typically focuses on the design of particulate carriers that are endowed with desirable membrane targeting, internalization, and endosomal escape properties. Topographical control of cell transfectability, however, remains a largely unexplored parameter. Emerging literature has highlighted the influence of cell-topography interactions on modulation of many cell phenotypes, including protein expression and cytoskeletal behaviors implicated in endocytosis. Using high-throughput screening of primary human dermal fibroblasts cultured on a combinatorial library of microscale topographies, we have demonstrated an improvement in nonviral transfection efficiency for cells cultured on dense micropit patterns compared to smooth substrates, as verified with flow...

British Library Electronic Table of Contents (United Kingdom)

Research on hematological disorders relies on suitable animal models. We retrospectively evaluated the use of the hematological parameters hematocrit (HCT), hemoglobin (HGB), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), mean corpuscular volume (MCV), red blood cell count (RBC), white blood cell count (WBC), and platelet count (PLT) in the phenotype-driven Munich N-ethyl-N-nitrosourea (ENU) mouse mutagenesis project as parameters for the generation of novel animal models for human diseases. The analysis was carried out on more than 16,000 G1 and G3 offspring of chemically mutagenized inbred C3H mice to detect dominant and recessive mutations leading to deviations in the levels of the chosen parameters. Identification of animals exhibiting altered valu...

British Library Electronic Table of Contents (United Kingdom)

The expression of motor activity levels in response to novel situations is under complex genetic and environmental control. Several genetic loci have been implicated in the regulation of this behavioral phenotype, but their relationship to epigenetic and epistatic interactions is relatively unknown. Here, we report on a quantitative trait locus (QTL) on mouse chromosome 1 for novelty-induced motor activity in the open field, using chromosome substitution strains derived from a high active host strain (C57BL/6J) and a low active donor strain (A/J). The QTL for open field (horizontal distance moved) peaked at the location of Kcnj9, however, QTL detection was initially masked by an interplay of both grandparent genetic origin and genetic co-factors influencing behavior on chromosome 1. Our fi...

British Library Electronic Table of Contents (United Kingdom)

Abstract Previous research has established the comorbidity of adult Attention-Deficit Hyperactivity Disorder (ADHD) with different personality disorders including Borderline Personality Disorder (BPD). The association between adult ADHD and BPD has primarily been investigated at the phenotypic level and not yet at the genetic level. The present study investigates the genetic and environmental contributions to the association between borderline personality traits (BPT) and ADHD symptoms in a sample of 7,233 twins and siblings (aged 18-90 years) registered with the Netherlands Twin Register and the East Flanders Prospective Twin Survey (EFPTS) . Participants completed the Conners' Adult ADHD Rating Scales (CAARS-S:SV) and the Personality Assessment Inventory-Borderline Features Scale (PAI-BO...

British Library Electronic Table of Contents (United Kingdom)

SNAP25 occurs on chromosome 20p12.2, which has been linked to schizophrenia in some samples, and recently linked to latent classes of psychotic illness in our sample. SNAP25 is crucial to synaptic functioning, may be involved in axonal growth and dendritic sprouting, and its expression may be decreased in schizophrenia. We genotyped 18 haplotype-tagging SNPs in SNAP25 in a sample of 270 Irish high-density families. Single marker and haplotype analyses were performed in FBAT and PDT. We adjusted for multiple testing by computing q values. Association was followed up in an independent sample of 657 cases and 411 controls. We tested for allelic effects on the clinical phenotype by using the method of sequential addition and 5 factor-derived scores of the OPCRIT. Nine of 18 SNPs had P values <...

UK PubMed Central (United Kingdom)

BackgroundThe endoscopic endonasal transsphenoidal approach (EETA) to the pituitary is performed by ear, nose, and throat (ENT) surgeons in collaboration with neurosurgeons but also...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

No abstract prepared.

UK PubMed Central (United Kingdom)

A patient with Cushing's syndrome due to a nonresectable chromophobe adenoma underwent external irradiation of the hypothalamic-pituitary area. The signs of Cushing's syndrome ameliorated subsequently...Full Text Available

UK PubMed Central (United Kingdom)

High-throughput technologies for DNA sequencing and for analyses of transcriptomes, proteomes and metabolomes have provided the foundations for deciphering the structure, variation and function of the...Full Text Available

UK PubMed Central (United Kingdom)

Spatial epidemiology is the description and analysis of geographic variations in disease with respect to demographic, environmental, behavioral, socioeconomic, genetic, and infectious risk factors....Full Text Available

UK PubMed Central (United Kingdom)

To evaluate the contribution of genetic influences on the individual variation in plateau serum salicylate levels, salicylate metabolism was studied in seven pairs of identical and six pairs of fraternal...Full Text Available

UK PubMed Central (United Kingdom)

BackgroundGenetic predisposition to scrapie in sheep is associated with several variations in the peptide sequence of the prion protein gene (PRNP). DNA-based tests...Full Text Available

UK PubMed Central (United Kingdom)

Frogs are characterized by a unique morphology associated with their saltatory lifestyle. Although variation in the form and function of the pelvic girdle and associated appendicular system related...Full Text Available

Science.gov (United States)

alloy (Ti6242 or T i l 100) was utilized. Parametric studies were performed to investigate variations of displacements and stresses with sandwich and ...

British Library Electronic Table of Contents (United Kingdom)

Plant secondary chemistry is determined by both genetic and environmental factors, and while large intraspecific variation in secondary chemistry has been reported frequently, the levels of genetic variation of many secondary metabolites in forest trees in the context of potential resistance against pests have been rarely investigated. We examined the effect of tree genotype and environment/site on the variation in defensive secondary chemistry of lodgepole pine, Pinus contorta var. latifolia, against the fungus, Grosmannia clavigera (formerly known as Ophiostoma clavigerum), associated with the mountain pine beetle, Dendroctonus ponderosae. Terpenoids were analyzed in phloem samples from 887, 20-yr-old trees originating from 45 half-sibling families planted at two sites. Samples were coll...

Energy Technology Data Exchange (ETDEWEB)

Using aggregate data for the counties of England and Wales, a negative association is found between mean radon concentrations in dwellings and lung cancer standardised mortality ratios, when regional smoking variations, diet variations, social class variations and population density are controlled. Cornwall and Devon have the highest mean domestic radon gas concentrations, yet the number of lung cancer deaths there was within the range to be expected from relationships not involving radon observed in the rest of the country. While high values of radon exposure appear to concentrate in particular localities, the variations in lung cancer mortality between districts in Cornwall and Devon are small. These findings do not refute the linear exposure-risk hypothesis, but the evidence suggests that relatively few, if any, radon related deaths were associated with the dwellings where radon gas concentrations ...

International Nuclear Information System (INIS)

1971. Australia Dorman, LI Yakhno, OI AN SSSR, Moscow. Inst. Zemnogo

UK PubMed Central (United Kingdom)

An epidemiological study about mastitis in French dairy herds, supported by an ecopathological survey is described. The aim of this work was to explain variations of the annual frequencies of...Full Text Available

DEFF Research Database (Denmark)

Objectives: The purpose of this work was to study the genetic determinants responsible for extended-spectrum beta-lactamase (ESBL) resistance of Salmonella isolated from Dutch poultry, poultry meat and hospitalized humans. Methods: Thirty-four ESBL-resistant Salmonella isolates from The Netherlands were tested towards 21 antimicrobial agents. PCR and sequencing were used to determine the underlying genetic determinants responsible for the ESBL phenotypes. The transferability of the ESBL phenotypes was tested by conjugation to a susceptible Salmonella enterica serovar Dublin and plasmid purification, restriction fragment length polymorphism (RFLP) and pulsed-field gel electrophoresis (PFGE) were employed to further characterize a subset of the isolates. Results: A great genetic diversity was seen among the isolates. The bla(TEM-52) gene was most predominant and was found among Salmonella enterica serovars Blockley, Thomson, London, Enteritidis ...

Energy Technology Data Exchange (ETDEWEB)

A 36-year-old woman underwent amniocentesis for advanced maternal age. The fetal karyotype had an extra dark staining G band on the long arm of chromosome 11 with no other identifiable abnormalities. FISH studies using a chromosome 11 paint probe confirmed the origin of the extra band. The abnormality was identified as a partial duplication of 11q: 46,XX dir dup (11)(q13.5q21) or (q21q23.1). The specific duplicated band could not be identified with certainty. Detailed fetal sonograms were normal. Family studies revealed the identical duplication in the mother but normal karyotypes in both maternal grandparents. The mother had strabismus and a short tongue frenulum which required surgical correction. Menses occurred late in adolescence and complete development of secondary sexual characteristics was delayed until adulthood. An infertility evaluation revealed duplication of the uterus, cervix, and vagina. An evaluation for metorrhagia identified a pituitary adenoma which was resected. ...

International Nuclear Information System (INIS)

IL-4-induced Stat6 signaling is active in a variety of cell types and plays a role in cell proliferation/growth and resistance to apoptosis. Using EMSA, we identified differential IL-4/Stat6 activities in colorectal cancer cell lines, HT-29 being active Stat6"h"i"g"h phenotype and Caco-2 being defective Stat6"n"u"l"l phenotype, respectively. Active Stat6"h"i"g"h HT-29 cells exhibited resistance to apoptosis by flowcytometry and aggressive metastasis by Transwell assay compared with defective Stat6"n"u"l"l Caco-2 cells. Comparing one another using RT-PCR, Stat6"h"i"g"h HT-29 cells expressed more mRNA of anti-apoptotic and pro-metastatic genes Survivin, MDM2, and TMPRSS4, while Stat6"n"u"l"l Caco-2 cells expressed more mRNA of pro-apoptotic and anti-metastatic genes BAX, CAV1, and P53, respectively. This is the first study describing correlations of IL-4/Stat6 activities with apoptosis and metastasis in colon cancer. These findings, together with ...

Energy Technology Data Exchange (ETDEWEB)

A radon detector with LR-115 nuclear track film was constructed for radon concentration measurements in soil. Temporal radon variations, as well as the barometric pressure, precipitation and temperature were measured for two years. Negative correlation between radon concentration in soil and barometric pressure was found. For some of the recorded earthquakes that occurred during the observation period, soil radon anomalies may be noticed one month before the quakes.

Energy Technology Data Exchange (ETDEWEB)

In order to illustrate morphological features and variations of temperature in the upper thermosphere, we performed numerical simulations with a whole atmosphere general circulation model (GCM) for the solar minimum and geomagnetically quiet conditions in March, June, September, and December. In previous GCMs, tidal effects were imposed at the lower boundaries assuming dominant diurnal and semi-diurnal tidal modes. Since the GCM used in the present study covers all the atmospheric regions, the atmospheric tides with various modes are generated within the GCM. The global temperature distributions obtained from the GCM are in agreement with ones obtained from NRLMSISE-00. In addition, the GCM also represents localised temperature structures which are superimposed on the global day-night distributions. These localised structures, which vary from hour to hour, would be observed as variations with periods of about 2-3 h at a single site. The ...

International Nuclear Information System (INIS)

Purpose: The aim of this study was to assess interinstitutional variations in planning for stereotactic body radiation therapy (SBRT) for lung cancer before the start of the Japan Clinical Oncology Group (JCOG) 0403 trial. Methods and Materials: Eleven institutions created virtual plans for four cases of solitary lung cancer. The created plans should satisfy the target definitions and the dose constraints for the JCOG 0403 protocol. Results: FOCUS/XiO (CMS) was used in six institutions, Eclipse (Varian) in 3, Cadplan (Varian) in one, and Pinnacle3 (Philips/ADAC) in one. Dose calculation algorithms of Clarkson with effective path length correction and superposition were used in FOCUS/XiO; pencil beam convolution with Batho power law correction was used in Eclipse and Cadplan; and collapsed cone convolution superposition was used in Pinnacle3. For the target volumes, the overall coefficient of variation was 16.6%, and the interinstitutional ...

CERN Document Server

An S-brane solution with two non-composite electric branes and a set of l scalar fields is considered. The intersection rule for branes corresponds to the Lie algebra A_2. The solution contains five factor spaces with the fifth one interpreted as ``our'' 3-dimensional space. It is shown that there exists a time interval where accelerating expansion of ``our'' 3-dimensional space is compatible with small enough value of effective gravitational ``constant'' variation.

CERN Document Server

We empirically investigated the relationships between the degree of efficiency and the predictability in financial time-series data. The Hurst exponent was used as the measurement of the degree of efficiency, and the hit rate calculated from the nearest-neighbor prediction method was used for the prediction of the directions of future price changes. We used 60 market indexes of various countries. We empirically discovered that the relationship between the degree of efficiency (the Hurst exponent) and the predictability (the hit rate) is strongly positive. That is, a market index with a higher Hurst exponent tends to have a higher hit rate. These results suggested that the Hurst exponent is useful for predicting future price changes. Furthermore, we also discovered that the Hurst exponent and the hit rate are useful as standards that can distinguish emerging capital markets from ...

UK PubMed Central (United Kingdom)

Game theory models of animal contests make many non-mutually exclusive predictions, complicating empirical tests. These predictions regard the relationship between contest parameters and fighting ability,...Full Text Available

UK PubMed Central (United Kingdom)

BackgroundDifferent microarray studies have compiled gene lists for predicting outcomes of a range of treatments and diseases. These have produced gene lists that have little overlap,...Full Text Available

UK PubMed Central (United Kingdom)

Regulatory agencies currently rely on rodent carcinogenicity bioassay data to predict whether or not a given chemical poses a carcinogenic threat to humans. We argue that it is always more useful to...Full Text Available

UK PubMed Central (United Kingdom)

BackgroundReplication capacity (RC) of specific HIV isolates is occasionally blamed for unexpected treatment responses. However, the role of viral RC in response to antiretroviral...Full Text Available

Science.gov (United States)

This report presents a summary of highlights of the year 1978. It then discusses: Research and development in numerical analysis and prediction systems; Techniques, development and application of new products; Analysis-forecast systems in operation use du...

UK PubMed Central (United Kingdom)

A method has been developed to predict the effects of mutations in the p53 cancer suppressor gene. The new method uses novel parameters combined with previously established parameters. The most important...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

Emissions of sulphur and nitrogen oxides are continuing to fall in Europe but rise in Asia, according to calculations based on individual countries' predictions of economic development. The upward trend is slower than in previous predictions. 2 refs., 2 figs., 2 tabs.