WorldWideScience
1

Multiorgan Detection and Characterization of Protease-Resistant Prion Protein in a Case of Variant CJD Examined in the United States  

UK PubMed Central (United Kingdom)

BackgroundVariant Creutzfeldt–Jakob disease (vCJD) is a prion disease thought to be acquired by the consumption of prion-contaminated beef products. To date, over 200 cases...Full Text Available

2

Amino acid substitutions in inherited albumin variants from Amerindian and Japanese populations  

International Nuclear Information System (INIS)

The authors report an effort to determine the basis for the altered migration of seven inherited albumin variants detected by one-dimensional electrophoresis in population surveys involving tribal Amerindians and Japanese children. An amino acid substitution has thus far been determined for four of the variants. The randomness in the albumin polypeptide of these and the other sixteen independently ascertained amino acid substitutions of albumin and proalbumin thus far established was analyzed; the clustering of eight of these at two positions in the six-amino acid propeptide sequence seems noteworthy. By comparison with other proteins studied by electrophoresis, albumin exhibits average variability. It is a paradox that individuals who, for genetic reasons, lack albumin exhibit no obvious ill effects; yet, electrophoretic variants of albumin are no more numerous than are variants of ...

3

Detecting variants with Metabolic Design, a new software tool to design probes for explorative functional DNA microarray development  

UK PubMed Central (United Kingdom)

BackgroundMicroorganisms display vast diversity, and each one has its own set of genes, cell components and metabolic reactions. To assess their huge unexploited metabolic potential...Full Text Available

4

Radiation-induced mutations at mouse hemoglobin loci  

International Nuclear Information System (INIS)

In experiments designed to detect new mutations affecting hemoglobin, we irradiated the male or female parent in reciprocal crosses of two mouse strains that differ in alleles at the hemoglobin (Hba, Hbb) loci as well as at five other specific loci. Offspring were analyzed for hemoglobin properties (electrophoretic pattern, solubility, crystal pattern), serum albumin differences, erythrocyte lysis, reticulocyte count, and external appearance. Five hemoglobin variants were found among the mutants. In three, the genetic contribution from the irradiated father was not expressed with regard to the #alpha#-chain; one carried a tandem duplication (the first known case in the mouse) involving Hbb; and one probably resulted from double nondisjunction of chromosome 7. The finding that major chromosome aberratios can mimic hemoglobin mutations indicates the need, in similar experiments, to follow F_1 screening with thorough cytogenetic analysis. The ...

5

Studies of human mutation rates  

Energy Technology Data Exchange (ETDEWEB)

November 1989, marked the beginning of a new three-year cycle of DOE grant support, in connection with which the program underwent a major reorganization. This document presents the progress on the three objectives of the present program which are: to isolate by the technique of two-dimensional polyacrylamide gel electrophoresis (2-D PAGE), proteins of special interest because of the relative mutability of the corresponding gene, establish the identity of the protein, and, for selected proteins, move to a characterization of the corresponding gene; to develop a more efficient approach, based on 2-D PAGE, for the detection of variants in DNA, with special reference to the identification of mutations in the parents of the individual whose DNA is being examined; and, to continue an effective interface with the genetic studies on the children of atomic bomb survivors in Japan, with reference to both the planning and implementation of new studies at ...

1990-01-01

6

Rapid detection of drugs in biofluids using atmospheric pressure chemi/chemical ionization mass spectrometry  

British Library Electronic Table of Contents (United Kingdom)

We have demonstrated that, with simple pH adjustment, volatile drugs such as methamphetamine, amphetamine, 3,4-methylenedioxymethamphetamine (MDMA), ketamine, and valproic acid could be analyzed rapidly from raw biofluid samples (e.g. urine and serum) without dilution, or extraction, using atmospheric pressure ionization. The ion source was a variant type of atmospheric pressure chemical ionization (APCI) that used a dielectric barrier discharge (DBD) to generate the metastable helium gas and reagent ions. The sample solution was loaded in a disposable glass pipette, and the volatile compounds were purged by nitrogen gas to be reacted with the metastable helium gas. The electrodes of the DBD were arranged in such a way that the generated glow discharge was confined within the discharge tub...

2009-01-01

7

Amino acid substitution: its use in detection and analysis of genetic variants  

International Nuclear Information System (INIS)

Techniques of chemical analysis, amino acid sequencing and autoradiography are being used to study the frequency of incorporation of normally noncoded amino acids into hemoglobins and seminal fluid proteins. We are studying, by the sequencing of radiolabeled proteins followed by the recovery of ["3H] isoleucine phenylthiohydantoin by high-performance liquid chromatography, the frequency at which normally noncoded isoleucine is incorporated into hemoglobin because of base-substitution mutations versus translational errors. Irradiation increases the isoleucine content of human hemoglobin and the frequency of substitution of isoleucine for specific amino acids in rabbit hemoglobin. Studies to date indicate that these techniques have been developed sufficiently for initial analysis of the potential of drugs and environmental pollutants to induce base-substitution mutations in mammalian somatic cells.

8

MRI in preoperative evaluation of chronic paranasal sinusitis - a comparison with CT  

International Nuclear Information System (INIS)

Purpose: To determine the value of MRI in the preoperative evaluation of chronic paranasal sinusitis and to compare the results with CT and intraoperative findings. Method/Materials: 42 patients with clinical signs of chronic paranasal sinusitis underwent MRI after CT evaluation on one day, with subsequent functional endoscopic sinus surgery on the next day. Coronary CT was obtained with 5-mm slices and table-feed in the prone position, while MRI was performed in the supine position with coronary T_2-TSE+pd and coronary and transverse HASTE, each with 5-mm slice thickness. Aquisition time in MRI was less than 8 minutes. Two radiologists reviewed the CT and MRI scans for signs of sinusitis and detection of anatomical landmarks. The results were correlated with the intraoperative findings. Results: MRI offered no artifacts of dental work and showed more often high quality pictures than CT. CT and MRI demonstrated a good correlation in the ...

2001-04-01

9

Molecular events involved in ionizing radiation induced skin carcinogenesis  

International Nuclear Information System (INIS)

The process of mouse skin tumor formation is subdivided into three operational stages. These stages include initiation, promotion and progression. Ionizing radiation has been found to be a weak initiating agent in the production of malignant squamous cell carcinomas, a complete carcinogen and an agent effective in causing tumor progression. Four skin tumor histologies have been seen with ionizing radiation: benign papillomas, squamous (SCC) and basal (BCC) cell carcinomas and fibrosarcomas. Distinct non-ras transforming genes have been detected in radiation initiated SCCs. A benign papilloma cell line (308) was used as a model system to study ionizing radiation induced progression. A variant 308 cell line (308 10 Gy 5) derived by irradiation of the parental 308 cell has been characterized. The 308 10 Gy 5 cells unlike the parental 308 cells from malignant tumors in athymic nude mice upon subcutaneous injection. The variant ...

10

Replication Stress Induces Genome-wide Copy Number Changes in Human Cells that Resemble Polymorphic and Pathogenic Variants  

UK PubMed Central (United Kingdom)

Copy number variants (CNVs) are an important component of genomic variation in humans and other mammals. Similar de novo deletions and duplications, or copy number changes (CNCs), are now known to be...Full Text Available

2009-03-13

11

Recurrent miscarriage and variant alleles of mannose binding lectin, tumour necrosis factor and lymphotoxin ? genes  

UK PubMed Central (United Kingdom)

Variant alleles of the mannose binding lectin (MBL) gene are associated with increased susceptibility to infection and polymorphisms of tumour necrosis factor and lymphotoxin alpha genes (TNF, LTA)...Full Text Available

2001-12-01

12

Persistence of genetic variants of the arctic fox strain of Rabies virus in southern Ontario  

UK PubMed Central (United Kingdom)

AbstractGenetic-variant analysis of rabies viruses provides the most sensitive epidemiologic tool for following the spread and persistence of these viruses in their wildlife hosts. Since...Full Text Available

2006-01-01

13

Molecular characterization of a Chinese variant of the Flury-LEP strain  

UK PubMed Central (United Kingdom)

The entire genome of rabies virus vaccine strain Flury-LEP-C, a Chinese variant of the rabies virus vaccine strain Flury-LEP, was sequenced. The overall length of the genome of Flury-LEP-C strain was...Full Text Available

14

A Computational Framework Discovers New Copy Number Variants with Functional Importance  

UK PubMed Central (United Kingdom)

Structural variants which cause changes in copy numbers constitute an important component of genomic variability. They account for 0.7% of genomic differences in two individual genomes, of which...Full Text Available

17

Infinitely many nontrivial solutions for a class of biharmonic equations via variant fountain theorems  

British Library Electronic Table of Contents (United Kingdom)

By a variant version of Fountain Theorem due to Zou [W. Zou, Variant fountain theorems and their applications, Manuscripta Math. 104 (2001) 343-358], the existence of infinitely many solutions is obtained for a class of biharmonic equations where the nonlinearity involves a combination of superlinear and asymptotically linear terms.

2011-01-01

18

Results of in-house cone-cup testing of low to high temperature SPF-alloys  

Energy Technology Data Exchange (ETDEWEB)

Material testing of SPF-sheet is usually done with coupon hot tensile testing. The optimum range of strain rates is determined with stepped strain tests. To overcome the problem of very few available testing facilities and time consuming and costly procedure, cone cup testing has been developed since long. This test can be generated directly in the workshop, no machining of samples is necessary and it is very much related to the real SPF-process. The analysis of suitable temperature and strain rate is done by simple measurement of resulting cone height. This paper describes a unique and novel variant of the above mentioned baseline design. It provides on-line data of the actual status of the cone cup forming resulting from the applied, constant pressure. Strain rate variations as a result from texture or from the alloy-related behaviour is detectable. Thinning and ''hardening'' behaviour of different alloys ...

2004-07-01

19

Crystallography of grain boundary #alpha# precipitates in a #beta# titanium alloy  

International Nuclear Information System (INIS)

The crystallography of #alpha#(hcp) precipitates formed on the #beta#(bcc) matrix grain boundaries has been studied with transmission electron microscopy (TEM) in a Ti-15V-3Cr-3Sn-3Al alloy. The #alpha# precipitates have a near-Burgers orientation relationship with respect to at least one of the adjacent #beta# grains. Among the possible 12 variants in this orientation relationship, the variant that [11 bar 20]_#alpha# is parallel to the _#beta# closest to the grain boundary plane tends to be preferred by the #alpha# precipitates. Additionally, further variant selections are made so as to minimize the deviation of orientation relationship with respect to the ''opposite'' #beta# grain from the Burgers one. Such rules in variant selection often result in the formation of precipitates with a single variant at a planar grain boundary. Prior small deformation of #beta# matrix changes the ...

1994-10-03

20

Tests for the diagnosis of Clostridium difficile infection: the next generation.  

Science.gov (United States)

Clostridium difficile (C. difficile) causes 25-30% of cases of antibiotic associated diarrhea and most cases of pseudomembranous colitis. Patients presenting with diarrhea after hospitalization for 3 or more days should be tested for C. difficile. There are many options available for testing, each of which has inherent advantages and disadvantages. Most laboratories perform toxin testing using an enzyme immunoassay method. In general these tests have sensitivities ranging from 60 to 70% and specificities of 98%. When using these methods, symptomatic patients with negative tests should be tested by another more sensitive method. Until recently, cell culture cytotoxicity neutralization assays (CCNAs) were considered the gold standard in the U.S. A two-step algorithm using an EIA for glutamate dehydrogenase detection followed by testing positives using CCNA, offered an improved alternative until the availability of molecular assays. Although early studies that ...

2011-03-03

21

Safe detection of Co-60. New perspectives in contamination and clearance measurements  

International Nuclear Information System (INIS)

Consistent application of a newly developed coincidence technique to determine activation products in the operation and demolition of nuclear facilities results in very new perspectives in contamination monitoring and clearance measurement of plant components. In particular, it is possible to avoid the critical spread of point-source Co-60 contamination, the so-called hot particles. The CCM (Cobalt Coincidence Measurement) technique includes the coincident detection of prompt-prompt gamma cascades with "6"0Co and other activation products ("1"1"0"mAg, "1"2"4Sb, "2"2Na) with low mass-specific limits for unrestricted clearance. Special features of the technique are the short measurement times, excellent signal-to-noise ratio, and focusing in space achieved. Compared to conventional integral gamma-measurements, the signal-to-background ratio can be improved by 1-2 orders of magnitude. The method can be employed especially where conventional integral or spectroscopic ...

22

The quasimolecular model in transitional nuclei  

International Nuclear Information System (INIS)

A review is made of some recent developments in the application of the Bohr Hamiltonian to transitional nulcei. The primary concern is to understand the advantages and limitations inherent to the basic model and its many variants. (author).

23

Pneumomediastinum as a complication of emphysematous cholecystitis: Case report  

UK PubMed Central (United Kingdom)

BackgroundEmphysematous cholecystitis is a variant of acute cholecystitis which is generally caused by gas-forming organisms. Emphysematous cholecystitis may cause gas spreading...Full Text Available

24

A Study of Avionics Time Division Multiplex Bus Simulation.  

Science.gov (United States)

... which may have embedded remote terminals, and (4 ... model the time-variant or stochastic aspects of ... on such system parameters as queue size, time ...

1980-12-01

25

Revisiting new variant famine: the case of Swaziland  

British Library Electronic Table of Contents (United Kingdom)

The ?new variant famine? hypothesis posits links between HIV/AIDS and new patterns of impoverishment, food insecurity and hunger, in southern and eastern Africa. This paper explores the relevance of the NVF hypothesis to understanding Swaziland?s recurrent food crises and high HIV prevalence. Evidence exists that all four markers of NVF are present in Swaziland. The national government and the international community will have to contend with this phenomenon in future planning for the wellbeing of Swazi citizens.

2009-01-01

26

New Variant of CTX-M-Type Extended-Spectrum ?-Lactamases, CTX-M-71, with a Gly238Cys Substitution in a Klebsiella pneumoniae Isolate from Bulgaria?  

UK PubMed Central (United Kingdom)

A single Klebsiella pneumoniae strain isolated in a Bulgarian hospital was found to produce CTX-M-71, a new CTX-M variant characterized by one amino acid substitution...Full Text Available

2009-10-01

27

Meta-Analysis for Genome-Wide Association Study Identifies Multiple Variants at the BIN1 Locus Associated with Late-Onset Alzheimer's Disease  

UK PubMed Central (United Kingdom)

Recent GWAS studies focused on uncovering novel genetic loci related to AD have revealed associations with variants near CLU, CR1, PICALM and BIN1....Full Text Available

28

Antigenic drift in influenza virus H3 hemagglutinin from 1968 to 1980: multiple evolutionary pathways and sequential amino acid changes at key antigenic sites.  

UK PubMed Central (United Kingdom)

Surveys of the antigenic properties of a wide range of variants of the H3N2 (Hong Kong) influenza virus subtype have revealed complex patterns of variants cocirculating during each of the main epidemic...Full Text Available

1983-10-01

29

Analysis of the 10q11 Cancer Risk Locus Implicates MSMB and NCOA4 in Human Prostate Tumorigenesis  

UK PubMed Central (United Kingdom)

Genome-wide association studies (GWAS) have established a variant, rs10993994, on chromosome 10q11 as being associated with prostate cancer risk. Since the variant is located outside of a protein-coding...Full Text Available

2010-11-01

30

Microstructural development inside the stress induced martensite variant in a Ti-Ni-Nb shape memory alloy  

Energy Technology Data Exchange (ETDEWEB)

The microstructural development inside the stress induced martensite (SIM) variants in Ti-Ni-Nb alloy with various degrees of deformation have been revealed by electron microscopic observations. The orientation relationship between the SIM and the parent phase has been found: [1{bar 1}0]{sub M}{parallel}[11{bar 1}]{sub B2}, (001){sub M} 5{degree} away from (101){sub B2}. The lattice invariant shear of the SIM variants at the slightly deformed stage is dominantly (11{bar 1}) Type I twin. Besides the ordinary slip, the adjustment and development of the internal secondary twinning from (11{bar 1}) Type I twin to {l_angle}011{r_angle} Type II/ or (011) Type I twin, (001)compound twin and (111) Type I twin happen concurrently or in combination inside the SIM variants with the further deformation. The corresponding deformation mechanisms include stress induced reorientation of SIM substructural bands by the most favorably ...

2000-04-03

31

The CYP2A3 gene product catalyzes coumarin 7-hydroxylation in human liver microsomes  

Energy Technology Data Exchange (ETDEWEB)

Three cDNAs, designated IIA3, IIA3v, and IIA4, coding for P450s in the CYP2A gene subfamily were isolated from a {lambda}gt11 library prepared from human hepatic mRNA. Only three nucleotide differences and a single amino acid difference, Leu{sup 160}{yields}His, were found between IIA3 and IIA3v, indicating that they are probably allelic variants. IIA4 displayed 94% amino acid similarity with IIA3 and IIA3v. The three cDNAs were inserted into vaccinia virus, and recombinant viruses were used to infect human hepatoma Hep G2 cells. Only IIA3 was able to produce an enzyme that had a reduced CO-bound spectrum with a {lambda}{sub max} at 450 nm. This expressed enzyme was able to carry out coumarin 7-hydroxylation and ethoxycoumarin O-deethylation. cDNA-expressed IIA3v and IIA4 failed to incorporate heme and were enzymatically inactive. Analysis of IIA proteins in human liver microsomes, using antibody against rat IIA2, revealed two proteins of 49 and 50 kDa, the former ...

1990-02-06

32

The CYP2A3 gene product catalyzes coumarin 7-hydroxylation in human liver microsomes  

International Nuclear Information System (INIS)

Three cDNAs, designated IIA3, IIA3v, and IIA4, coding for P450s in the CYP2A gene subfamily were isolated from a #lambda#gt11 library prepared from human hepatic mRNA. Only three nucleotide differences and a single amino acid difference, Leu"1"6"0#->#His, were found between IIA3 and IIA3v, indicating that they are probably allelic variants. IIA4 displayed 94% amino acid similarity with IIA3 and IIA3v. The three cDNAs were inserted into vaccinia virus, and recombinant viruses were used to infect human hepatoma Hep G2 cells. Only IIA3 was able to produce an enzyme that had a reduced CO-bound spectrum with a #lambda#_m_a_x at 450 nm. This expressed enzyme was able to carry out coumarin 7-hydroxylation and ethoxycoumarin O-deethylation. cDNA-expressed IIA3v and IIA4 failed to incorporate heme and were enzymatically inactive. Analysis of IIA proteins in human liver microsomes, using antibody against rat IIA2, revealed two proteins of 49 and 50 kDa, the former of ...

1990-02-01

33

Sequence analysis of the ATM gene in 20 patients with RTOG grade 3 or 4 acute and/or late tissue radiation side effects  

International Nuclear Information System (INIS)

Purpose: Patients with ataxia-telangiectasia (A-T) show greatly increased radiation sensitivity and cancer predisposition. Family studies imply that the otherwise clinically silent heterozygotes of this autosomal recessive disease run a 3.5 to 3.8 higher risk of developing cancer. In vitro studies suggest moderately increased cellular radiation sensitivity of A-T carriers. They may also show elevated clinical radiosensitivity. We retrospectively examined patients who presented with severe adverse reactions during or after standard radiation treatment for mutations in the gene responsible for A-T, ATM, considering a potential means of future identification of radiosensitive individuals prospectively to adjust dosage schedules. Material and Methods: We selected 20 cancer patients (breast, 11; rectum, 2; ENT, 2; bladder, 1; prostate, 1; anus, 1; astrocytoma, 1; Hodgkins lymphoma, 1) with Grade 3 to 4 (RTOG) acute and/or late tissue radiation side effects by reaction severity. DNA from the ...

1999-07-15

34

Particle Detection with drift Chambers  

CERN Document Server

Particle Detection with drift Chambers

2008-01-01

35

Genomic architecture of aggression: Rare copy number variants in intermittent explosive disorder  

British Library Electronic Table of Contents (United Kingdom)

Abstract Copy number variants (CNVs) are known to be associated with complex neuropsychiatric disorders (e.g., schizophrenia and autism) but have not been explored in the isolated features of aggressive behaviors such as intermittent explosive disorder (IED). IED is characterized by recurrent episodes of aggression in which individuals act impulsively and grossly out of proportion from the involved stressors. Previous studies have identified genetic variants in the serotonergic pathway that play a role in susceptibility to this behavior, but additional contributors have not been identified. Therefore, to further delineate possible genetic influences, we investigated CNVs in individuals diagnosed with IED and/or personality disorder (PD). We carried out array comparative genomic hybridizati...

2011-01-01

36

A generic quantum walk using a coin-embedded shift operator  

CERN Document Server

The study of quantum walk process has been widely divided into the two standard variants, the discrete-time quantum walk (DTQW) and the continuous-time quantum walk (CTQW). The connection between the two variants has been established by considering limiting value of the coin operation parameter in the DTQW and the coin degree of freedom is show to be unnecessary [26]. But the coin degree of freedom is an additional resource which can be exploited to control the dynamics of the QW process. In this paper we present a generic quantum walk (QW) model using a quantum coin-embedded unitary shift operation U_{C}. The standard version of the DTQW and the CTQW can be conveniently retrieved from this generic model retaining the features of the coin degree of freedom in both the variants.

2008-01-01

37

Variants within the yeast Ty sequence family encode a class of structurally conserved proteins.  

UK PubMed Central (United Kingdom)

The Ty transposable elements of Saccharomyces cerevisiae form a heterogeneous family within which two broad structural classes (I and II) exist. The two classes differ by two large substitutions and...Full Text Available

1985-06-11

38

Variants in Inflammation Genes and the Risk of Biliary Tract Cancers and Stones: A Population-based Study in China  

UK PubMed Central (United Kingdom)

To evaluate the role of chronic inflammation in the development of gallstones and biliary tract cancer, we examined the risk associated with 62 single nucleotide polymorphisms (SNPs), including...Full Text Available

2008-08-01

39

Variant influenza virus hemagglutinin that induces fusion at elevated pH.  

UK PubMed Central (United Kingdom)

The hemagglutinin (HA) glycoprotein of influenza virus performs two critical roles during infection: it binds virus to cell surface sialic acids, and under mildly acidic conditions it induces fusion...Full Text Available

1986-02-01

40

Transmitted drug resistance in nonsubtype B HIV-1 infection  

UK PubMed Central (United Kingdom)

HIV-1 nonsubtype B variants account for the majority of HIV infections worldwide. Drug resistance in individuals who have never undergone antiretroviral therapy can lead to early failure and...Full Text Available

2009-09-01

41

The influence of prior ageing on creep damage development in two variants of Alloy 800  

Energy Technology Data Exchange (ETDEWEB)

The influence of high temperature thermal ageing treatments on the development of intercrystalline creep damage in two variants of Alloy 800 has been investigated. Ageing up to 3000 h and creep testing were carried out at 800 and 900 C. The high temperature behaviour of the 800HT variant is discussed with reference to the effect of heat treatments on the microstructure. The metallographic methods by which the creep damage was quantitatively determined are described. The growth rate of intercrystalline microcracks was described using a statistical model and the dependence of crack growth rate on the thermal history for both 800HT and 800H was determined. The carbide precipitation and growth processes were determined as functions of the exposure temperature and duration. The results showed the three characteristic stages, precipitation, growth and coarsening (Ostwald ripening). The largest increase in the intergranular creep damage was found in ...

1997-06-01

42

The Association of Alcohol and Alcohol Metabolizing Gene Variants with Diabetes and Coronary Heart Disease Risk Factors in a White Population  

UK PubMed Central (United Kingdom)

BackgroundEpidemiological studies have shown a J- or U-shaped relation between alcohol and type 2 diabetes and coronary heart disease (CHD). The underlying mechanisms are not clear....Full Text Available

43

Soluble Variants of Rhodobacter capsulatus Membrane-anchored Cytochrome cy Are Efficient Photosynthetic Electron Carriers*  

UK PubMed Central (United Kingdom)

Photosynthetic (Ps) electron transport pathways often contain multiple electron carriers with overlapping functions. Here we focus on two c-type cytochromes (cyt) in facultative phototrophic...Full Text Available

2008-05-16

44

Sequence variants of the DFNB31 gene among Usher syndrome patients of diverse origin  

UK PubMed Central (United Kingdom)

PurposeIt has been demonstrated that mutations in deafness, autosomal recessive 31 (DFNB31), the gene encoding whirlin, is responsible for nonsyndromic hearing loss...Full Text Available

45

Properties of a cell-wall-defective variant of Brucella abortus of bovine origin.  

UK PubMed Central (United Kingdom)

The properties of an atypical Brucella strain isolated from lymph node tissue of a cow slaughtered as a brucellosis reactor were examined. The organism was Gram negative and highly pleomorphic, existing...Full Text Available

1980-08-01

46

Olfactory copy number association with age at onset of Alzheimer disease  

UK PubMed Central (United Kingdom)

Objectives:Copy number variants (CNVs) have been recognized as a source of genetic variation that contributes to disease phenotypes. Alzheimer disease (AD) has high heritability...Full Text Available

2011-04-12

47

New common variants affecting susceptibility to basal cell carcinoma  

UK PubMed Central (United Kingdom)

In a follow-up to our previously reported genome-wide association study of cutaneous basal cell carcinoma (BCC)1, we describe here several new susceptibility...Full Text Available

2009-08-01

48

Multiplicity of Plasmodium falciparum infection in asymptomatic children in Senegal: relation to transmission, age and erythrocyte variants  

UK PubMed Central (United Kingdom)

BackgroundIndividuals living in malaria endemic areas generally harbour multiple parasite strains. Multiplicity of infection (MOI) can be an indicator of immune status. However,...Full Text Available

49

Multiple Genes on Chromosome 7 Regulate Dopaminergic Amacrine Cell Number in the Mouse Retina  

UK PubMed Central (United Kingdom)

PurposeThe size of neuronal populations is modulated by gene variants that influence cell production and survival, in turn influencing neuronal connectivity, function,...Full Text Available

2009-05-01

50

Investigation of Dyslexia and SLI Risk Variants in Reading- and Language-Impaired Subjects  

UK PubMed Central (United Kingdom)

Dyslexia (or reading disability) and specific language impairment (or SLI) are common childhood disorders that show considerable co-morbidity and diagnostic overlaps and have been suggested to share...Full Text Available

2011-01-01

51

Identification of the binding domain for NADP"+ of human glucose-6-phosphate dehydrogenase by sequence analysis of mutants  

International Nuclear Information System (INIS)

Human erythrocyte glucose-6-phosphate is normally quite stable in the presence of 10 #mu#M NADP"+. Certain glucose-6-phosphate dehydrogenase variants lose virtually all their activity at this concentration of NADP"+ but are reactivated by 200 #mu#M NADP"+. Such variants presumably have a defect in their NADP"+-binding site. The authors analyzed the sequence of cDNA or genomic DNA from seven unrelated patients with hemolytic anemia due to the inheritance of variants that are reactivated by NADP"+. Six patients had substitutions of one of three adjacent amino acids, and the seventh patient had another amino acid substitution 23 residues downstream. These amino acids are highly conserved, all being present in rat and all but one being found also in Drosophila. The anomalous electrophoretic behavior of some of the variants can be explained by their loss of ability to bind NADP"+. The conclude that the ...

52

Functional significance of UDP-glucuronosyltransferase (UGT) variants in the metabolism of active tamoxifen metabolites  

UK PubMed Central (United Kingdom)

Tamoxifen (TAM) is a selective estrogen receptor modulator widely used in the prevention and treatment of breast cancer. A major mode of metabolism of the major active metabolites of TAM, 4-OH-TAM...Full Text Available

2009-03-01

53

Endovascular treatment of a Superior Mesenteric Artery Syndrome variant secondary to traumatic pseudoaneurysm  

UK PubMed Central (United Kingdom)

Pseudoaneurysms related to the superior mesenteric artery (SMA) are a recognised complication of trauma to the vessel, and successful treatment with stenting has been previously described. We report...Full Text Available

54

Dedifferentiated liposarcoma of the small bowel mesentery presenting as a submucosal mass  

UK PubMed Central (United Kingdom)

Dedifferentiated liposarcoma (DDLPS) is a variant of liposarcoma but with a more aggressive course. It occurs most commonly in the retroperitoneum and rarely in any other anatomical location. We describe...Full Text Available

2011-07-15

55

Common Genetic Variants Associate with Serum Phosphorus Concentration  

UK PubMed Central (United Kingdom)

Phosphorus is an essential mineral that maintains cellular energy and mineralizes the skeleton. Because complex actions of ion transporters and regulatory hormones regulate serum phosphorus concentrations,...Full Text Available

2010-07-01

56

Cellobiose dehydrogenase from Phanerochaete chrysosporium is encoded by two allelic variants.  

UK PubMed Central (United Kingdom)

The complete nucleotide sequences of two alleles of cellobiose dehydrogenase, cdh-1 (3,627 bp) and cdh-2 (3,623 bp), from Phanerochaete chrysosporium OGC101 are reported. The nucleotide sequences of...Full Text Available

1997-02-01

57

Animal models of human amyloidoses: Are transgenic mice worth the time and trouble?  

UK PubMed Central (United Kingdom)

The amyloidoses are the prototype gain of toxic function protein misfolding diseases. As such, several naturally occurring animal models and their inducible variants provided some of the first...Full Text Available

2009-08-20

58

Angiomatoid giant cellular blue nevus of vaginal wall associated with pregnancy  

UK PubMed Central (United Kingdom)

BackgroundBlue nevi that arise from the Müllerian tract are rare melanocytic lesions. Several histopathologic variants of cellular blue nevi have been described. The angiomatoid...Full Text Available

59

A Spindle Cell Predominant Pancreatic Solid-pseudopapillary Tumor  

UK PubMed Central (United Kingdom)

A hitherto unrecognized variant of solid-pseudopapillary tumor (SPT) of the pancreas is reported. The tumor presented in the pancreatic tail of a 44-year-old female patient. It was a well-defined, solid...Full Text Available

2008-08-30

60

A Nitrate Reductase-less Variant Isolated from Suspension Cultures of Datura innoxia (Mill.) 1  

UK PubMed Central (United Kingdom)

A comparative study has been carried out of the growth of two lines of Datura innoxia (Mill.) cells, designated DI-6 and NR1, their resistance to chlorate, and their ability to assimilate...Full Text Available

1980-10-01

61

A Cytogenetic Abnormality and Rare Coding Variants Identify ABCA13 as a Candidate Gene in Schizophrenia, Bipolar Disorder, and Depression  

UK PubMed Central (United Kingdom)

Schizophrenia and bipolar disorder are leading causes of morbidity across all populations, with heritability estimates of ∼80% indicating a substantial genetic component. Population genetics...Full Text Available

2009-12-11

62

Mitochondrial DNA variants in Drosophila melanogaster are expressed at the level of the organismal phenotype.  

Science.gov (United States)

A plethora of experimental studies use mtDNA as a marker of demographic processes without questioning the possibility that selection may bias their interpretations. We studied four lines of Drosophila melanogaster that have a standardized nuclear DNA but variable mtDNA. We completed the sequencing of the mitochondrial genomes (excluding the A+T rich region) and compiled the differences. We then assayed male influence on oviposition, starvation resistance, lipid proportion and physical activity. We discuss these results in terms of the known differences between the lines and conclude that naturally occurring mtDNA variants in D. melanogaster are expressed at the level of the organismal phenotype. PMID:21757031

2011-07-05

63

The ZNF804A gene: characterization of a novel neural risk mechanism for the major psychoses.  

Science.gov (United States)

Schizophrenia and bipolar disorder share genetic risk, brain vulnerability, and clinical symptoms. The ZNF804A risk variant, rs1344706, confers susceptibility for both disorders. This study aimed to identify neural mechanisms common to both schizophrenia and bipolar disorder through this variant's potential effects on cortical thickness, white matter tract integrity, and cognitive function. Imaging, genetics, and cognitive measures were ascertained in 62 healthy adults aged between 18 and 59 years. High-resolution multimodal MRI/DTI imaging was used to measure cortical thickness and major frontotemporal and interhemispheric white matter tracts. The general linear model was used to examine the influence of the ZNF804A rs1344706 risk variant on cortical thickness, white matter tract integrity, and cognitive measures. Individuals homozygous for the risk variant ('A' allele) demonstrated reduced cortical ...

2011-04-27

64

MRI in preoperative evaluation of chronic paranasal sinusitis - a comparison with CT; MRT in der praeoperativen Diagnostik der chronischen Sinusitis im Vergleich mit der CT  

Energy Technology Data Exchange (ETDEWEB)

Purpose: To determine the value of MRI in the preoperative evaluation of chronic paranasal sinusitis and to compare the results with CT and intraoperative findings. Method/Materials: 42 patients with clinical signs of chronic paranasal sinusitis underwent MRI after CT evaluation on one day, with subsequent functional endoscopic sinus surgery on the next day. Coronary CT was obtained with 5-mm slices and table-feed in the prone position, while MRI was performed in the supine position with coronary T{sub 2}-TSE+pd and coronary and transverse HASTE, each with 5-mm slice thickness. Aquisition time in MRI was less than 8 minutes. Two radiologists reviewed the CT and MRI scans for signs of sinusitis and detection of anatomical landmarks. The results were correlated with the intraoperative findings. Results: MRI offered no artifacts of dental work and showed more often high quality pictures than CT. CT and MRI demonstrated a good correlation in the ...

2001-04-01

65

Texture transformations in thermomechanically treated steels having increased nitrogen content and alloys  

International Nuclear Information System (INIS)

In this study the results of mathematical simulation and experimental research of texture transition in stress assisted shear phase transformations are discussed. The orientation distribution function (ODF) calculation model to the any type crystalline lattice symmetry materials has been suggested. By crystalline lattice symmetry analysis this computer program determines necessary amount of the initial experimental data. The experimental verification supports this model well. The ODF calculation model after shear phase transformation with equal use of all possible variants of orientation relationship or with various degrees of variant selection worked out. In this study the experimental and calculating data of the direct and reversal shear transformations #alpha# <=> #gamma# in Fe-alloys and B2 <=> B19' in Ti-Ni alloys are discussed. The stress assisted shear phase transformation model and computer program to calculate ODF after ...

66

Strategies and computational tools for improving randomized protein libraries.  

Science.gov (United States)

In the last decade, directed evolution has become a routine approach for engineering proteins with novel or altered properties. Concurrently, a trend away from purely 'blind' randomization strategies and towards more 'semi-rational' approaches has also become apparent. In this review, we discuss ways in which structural information and predictive computational tools are playing an increasingly important role in guiding the design of randomized libraries: web servers such as ConSurf-HSSP and SCHEMA allow the prediction of sites to target for producing functional variants, while algorithms such as GLUE, PEDEL and DRIVeR are useful for estimating library completeness and diversity. In addition, we review recent methodological developments that facilitate the construction of unbiased libraries, which are inherently more diverse than biased libraries and therefore more likely to yield improved variants. PMID:16095966

2005-10-01

67

Quantization in the presence of Gribov ambiguities  

Energy Technology Data Exchange (ETDEWEB)

The non-perturbative validity of covariant BRST-quantization of gauge theories on compact Euclidean space-time manifolds is reviewed. BRST-quantization is related to the construction of a Topological Quantum Field Theory (TQFT) of Witten type on the gauge group. The criterion for the non-perturbative validity of the quantization is that the partition function of the corresponding TQFT does not vanish and that its (equi-variant) BRST-algebra is free of anomalies. I sketch the construction of a TQFT whose partition function is proportional to the generalized Euler-characteristic of the coset space S U (n){sub gauge} / SU(n){sub global} with an associated equi-variant BRST-algebra that manifestly preserves translational symmetry. Some non-perturbative consequences of this approach are discussed. (author)

1999-07-01

68

Ecological utilization of wastes. A manual for optimum waste management concepts. 3. rev. ed. Oekologische Muellverwertung. Handbuch fuer optimale Abfall-Konzepte  

Energy Technology Data Exchange (ETDEWEB)

From out of the numerous technical alternatives the manual develops a waste management concept with emphasis on methods which can be coordinated for maximum ecological use and minimum economic costs. A clear-cut analysis of the present state of waste utilization and waste disposal in the Federal Republic of Germany (chapter 1) is followed by a detailed description of conventional and modern state-of-the-art waste utilization methods based on ecological evaluation criteria (chapter 3). An optimum waste utilization concept for defined quantities of wastes is derived from the ecological and economic comparison of waste utilization techniques given in chapter 3. Chapter 4 points out different variants of waste utilization and waste disposal methods and shows how to determine the optimum variant of the optimum concept for a particular area or community. (orig.).

1991-01-01

69

Ultrasensitive fluorescence detection of DNA  

Science.gov (United States)

Progress on Ultrasensitive fluorescence detection of DNA is briefly described. (CBS)

1991-01-01

71

Fluorescent Silicate Materials for the Detection of Paraoxon  

Science.gov (United States)

... significantly lower limits of detection. The complex fluorescence spectra of these constructs indicated that only a portion ...

2010-03-19

72

The normal developmental regulation of a cloned sgs3 'glue' gene chromosomally integrated in Drosophila melanogaster by P element transformation.  

UK PubMed Central (United Kingdom)

A 7-kb genomic segment containing the coding sequence for the Drosophila melanogaster Formosa variant of salivary gland secretion protein 3 (sgs3) has been inserted into the snw y, bw, st strain of...Full Text Available

1983-01-01

73

The human gastrin/cholecystokinin type B receptor gene: alternative splice donor site in exon 4 generates two variant mRNAs.  

UK PubMed Central (United Kingdom)

Gastrin and its carboxyl-terminal homolog cholecystokinin (CCK) exert a variety of biological actions in the brain and gastrointestinal tract that are mediated in part through one or more G protein-coupled...Full Text Available

1993-10-01

74

The PTPN22 allele encoding an R620W variant interferes with the removal of developing autoreactive B cells in humans  

UK PubMed Central (United Kingdom)

Protein tyrosine phosphatase nonreceptor type 22 (PTPN22) gene polymorphisms are associated with many autoimmune diseases. The major risk allele encodes an R620W amino acid change that...Full Text Available

2011-09-01

75

Ternary aluminides LnPd[sub 2]Al with YPd[sub 2]Si-type structure  

Energy Technology Data Exchange (ETDEWEB)

Attempts to synthesize YPd[sub 2]Si-type representatives LnPd[sub 2]Al were successful only with Ln triple bond Ce, Pr, Nd. This orthorhombic structure (oP16; space group Pnma) is an ordered variant of the Fe[sub 3]C type. Only NdPd[sub 2]Al undergoes magnetic ordering above 2 K. (orig.)

1993-04-13

76

Selective Expression in Carotid Body Type I Cells of a Single Splice Variant of the Large Conductance Calcium- and Voltage-activated Potassium Channel Confers Regulation by AMP-activated Protein Kinase*  

UK PubMed Central (United Kingdom)

Inhibition of large conductance calcium-activated potassium (BKCa) channels mediates, in part, oxygen sensing by carotid body type I cells. However, BKCa channels remain active...Full Text Available

2011-04-08

77

Prediction of conformational changes by single mutation in the hepatitis B virus surface antigen (HBsAg) identified in HBsAg-negative blood donors  

UK PubMed Central (United Kingdom)

BackgroundSelection of hepatitis B virus (HBV) by host immunity has been suggested to give rise to variants with amino acid substitutions at or around the 'a' determinant...Full Text Available

78

Polyadenylated H3 histone transcripts and H3 histone variants in alfalfa.  

UK PubMed Central (United Kingdom)

Histone H3 mRNAs were found in polyA(+) fractions of total RNA prepared from alfalfa plants, calli and somatic embryos. The sequence analysis of cDNAs revealed the presence of a polyA tail on independent...Full Text Available

1989-04-25

79

Pitting corrosion on a copper canister; Gropfraetning paa kopparkapsel  

Energy Technology Data Exchange (ETDEWEB)

It is demonstrated that normal pitting can occur during oxidizing conditions in the repository. It is also concluded that a new theory for pitting corrosion has to be developed, as the present theory is not in accordance with all practical and experimental observations. A special variant of pitting, based on the growth of sulfide whiskers, is suggested to occur during reducing conditions. However, such a mechanism needs to be demonstrated experimentally. A simple calculational model of canister corrosion was developed based on the results of this study. 69 refs, 3 figs.

1996-02-01

80

High yielding mutants in sesamum  

International Nuclear Information System (INIS)

Mutation breeding in one of the cultigens TMV-5 in Sesamum is undertaken with 5 kr, 10 kr, 15 kr, 20 kr, 60 kr and 80 kr, dosages of gamma-rays. 60 kr and 80 kr dosages were found to be lethal from the complete failure of seed germination. The mutagen had a heterotic effect on the different characters and the promising variants obtained in this programme are proposed to be maintained by pureline breeding for their possible release as new varieties. (author).

81

Helper T-Cell Epitopes Encoded by the Babesia bigemina rap-1 Gene Family in the Constant and Variant Domains Are Conserved among Parasite Strains  

UK PubMed Central (United Kingdom)

Among important candidates for babesial vaccines are apical complex proteins, including rhoptry-associated protein 1 (RAP-1) from Babesia bovis and B. bigemina, which...Full Text Available

1998-04-01

82

Heat recovery in foundries  

Energy Technology Data Exchange (ETDEWEB)

A great deal of energy is necessary to manufacture castings, the greater part of which is wasted. Some general instructions are given on how to keep this part as low as possible. This is discussed particularly using the example of a heat recovery plant for foundries, especially in the melting and cooling of castings with the use of cupola furnace stack gas to produce hot gas. Further variants for recovering heat from the individual stages of a foundry process are listed. There are data on using this heat in operation.

1982-01-01

83

Enantioselective Transformation of ?-Hexachlorocyclohexane by the Dehydrochlorinases LinA1 and LinA2 from the Soil Bacterium Sphingomonas paucimobilis B90A  

UK PubMed Central (United Kingdom)

Sphingomonas paucimobilis B90A contains two variants, LinA1 and LinA2, of a dehydrochlorinase that catalyzes the first and second steps in the metabolism of hexachlorocyclohexanes (R....Full Text Available

2005-12-01

84

Chromosomal Integration of the Extended-Spectrum ?-Lactamase Gene blaCTX-M-15 in Salmonella enterica Serotype Concord Isolates from Internationally Adopted Children?  

UK PubMed Central (United Kingdom)

We report the emergence of Salmonella enterica isolates of serotype Concord (and its monophasic variant 6,7:l,v:-) producing the extended-spectrum β-lactamases (ESBLs) SHV-12...Full Text Available

2009-05-01

85

Astrocytes derived from trisomic human embryonic stem cells express markers of astrocytic cancer cells and premalignant stem-like progenitors  

UK PubMed Central (United Kingdom)

BackgroundTrisomic variants of human embryonic stem cells (hESCs) arise spontaneously in culture. Although trisomic hESCs share many properties with diploid hESCs, they also exhibit...Full Text Available

86

A quenched c = 1 critical matrix model  

Energy Technology Data Exchange (ETDEWEB)

We study a variant of the Penner-Distler-Vafa model, proposed as a c = 1 quantum gravity: quenched' matrix model with logarithmic potential. The model is exactly soluble, and exhibits a two-cut branching as observed in multicritical unitary matrix models and multicut Hermitian matrix models. Using analytic continuation of the power in the conventional polynomial potential, we also show that both the Penner-Distler-Vafa model and our quenched' matrix model satisfy Virasoro algebra constraints.

1990-12-01

87

A genome-wide association study of cleft lip with and without cleft palate identifies risk variants near MAFB and ABCA4  

UK PubMed Central (United Kingdom)

Case-parent trios were used in a genome wide association study of cleft lip with/without cleft palate (CL/P). SNPs near two genes not previously associated with CL/P [MAFB:...Full Text Available

2010-06-01

91

Network Security Defense Tools  

Science.gov (United States)

Lecturo on Firewalls, VPNs, Intrusion Detection, and filters

2009-02-11

95

NOZZLE WEAR DETECTION IN ABRASIVE WATERJET ...  

Science.gov (United States)

... Accession Number : ADD330829. Title : NOZZLE WEAR DETECTION IN ABRASIVE WATERJET CUTTING SYSTEMS,. Corporate Author : ...

1990-03-01

96

Electron-Induced Luminescence and X-Ray Spectrometer (ELXS) System for Life Detection  

Science.gov (United States)

The ELXS concept is a novel, portable, micro-instrument targeted for the detection of mineralogic

2002-01-01

97

Detection of the heavy Higgs boson at [gamma][gamma] colliders  

Energy Technology Data Exchange (ETDEWEB)

We consider the possibility of detecting a heavy Higgs boson ([ital m][sub [ital H

1993-07-01

98

Single Atom Detection With Optical Cavities  

CERN Document Server

We present a thorough analysis of single atom detection using optical cavities. The large set of parameters that influence the signal-to-noise ratio for cavity detection is considered, with an emphasis on detunings, probe power, cavity finesse and photon detection schemes. Real device operating restrictions for single photon counting modules and standard photodiodes are included in our discussion, with heterodyne detection emerging as the clearly favourable technique, particularly for detuned detection at high power.

2008-01-01

99

Explosives detection: the problem and prospects  

Energy Technology Data Exchange (ETDEWEB)

The history of explosives vapor detection includes almost every detection strategy known to man. Initial attempts to utilize these techniques were dismal failures. However, with the development of the Electron Capture Detector (ECD), the first promising detection of explosives vapors became possible. The present commercial explosives detectors detect the higher vapor pressure materials but not the whole spectrum. This paper describes the basic properties of explosives molecules and our research to utilize these properties for increased detection sensitivity.

1984-01-01

100

Polymorphism in HTR3D shows different risks for acute chemotherapy-induced vomiting after anthracycline chemotherapy  

British Library Electronic Table of Contents (United Kingdom)

Aims: Serotonin (5-hydroxytryptamine 3; 5-HT3) receptors are involved in chemotherapy-induced nausea and vomiting (CINV), and 5-HT3 antagonists are part of the `gold standard' antiemetic treatment during chemotherapy. We investigated the correlation of common variants in 5-HT3 receptor subunit genes with the occurrence of CINV. Materials & methods: A total of 110 previously characterized chemotherapy-naive women with primary breast cancer treated with anthracycline-containing chemotherapy served as a study group for mutational analysis by direct sequencing. Eight common SNPs in the 5-HT3 receptor genes, HTR3A, HTR3B, HTR3D and HTR3E, were selected for association analysis. Results: A nonsynonymous variant in HTR3D, p.G36A (rs6443930), was found to be over-represented in nonresponders, assu...

2010-01-01

101

Improvement of banana through biotechnology and mutation breeding  

International Nuclear Information System (INIS)

Protocols were standardized for in vitro propagation of several elite and diverse banana accessions using shoot tip explants. Tissue culture raised plants were field planted at multiple locations. Studies were undertaken for the induction of mutations using multiple shoot cultures of six selected cultivars, Shreemanti (AAA), Basrai (AAA), Lal Kela (AAA), Rasthali (AAB), Karibale Monthan (ABB) and a wild diploid (BB). These shoot cultures were irradiated at different doses of gamma rays (0-100 Gy) and subcultured thrice (up to M_1V_3) to separate shimeras, followed by induction of rooting (M_1V_4). In general, the rate of multiplication had a negative association with the dose of gamma rays. Enhanced multiplication of shoots was noticed at lower doses. The proliferation of shoots was arrested beyond 50 Gy and a dose of 70 Gy was completely lethal for all the genotypes studied. The rooted plantlets were hardened in the green house and in the early stages of field growth, a few ...

1998-10-01

102

A CD33-specific single-chain immunotoxin mediates potent apoptosis of cultured human myeloid leukaemia cells.  

Science.gov (United States)

A novel single-chain immunotoxin was constructed by combining a CD33-specific single chain Fv (scFv) antibody fragment with an engineered variant of Pseudomonas exotoxin A (ETA). The variant toxin carries the KDEL peptide at its C-terminus, a cellular peptide mediating improved retrograde transport to the endoplasmic reticulum. The purified recombinant fusion protein induced potent apoptosis of the human myeloid cell lines U937, HL-60 and THP-1. Up to 98% of U937 cells were eliminated after treatment for 72 h with a single dose of 500 ng/ml (c. 7 nmol/l). Killing was antigen-specific and occurred by apoptosis. A control protein, consisting of a CD19-specific scFv antibody fragment fused to the ETA-KDEL toxin, failed to induce death of the CD19-negative cell lines U937, HL-60 and THP-1. The CD33-ETA toxin also mediated apoptosis of fresh patient-derived acute myeloid leukaemia cells from bone marrow and peripheral blood. The pronounced ...

2006-04-01

103

Performance Comparisons of PSO based Clustering  

CERN Document Server

In this paper we have investigated the performance of PSO Particle Swarm Optimization based clustering on few real world data sets and one artificial data set. The performances are measured by two metric namely quantization error and inter-cluster distance. The K means clustering algorithm is first implemented for all data sets, the results of which form the basis of comparison of PSO based approaches. We have explored different variants of PSO such as gbest, lbest ring, lbest vonneumann and Hybrid PSO for comparison purposes. The results reveal that PSO based clustering algorithms perform better compared to K means in all data sets.

2010-01-01

104

IDEAS: The Science, Sociology and Economics of Food Production and Access to Food, Springer  

Wastenet

... (restricted)] 251-260 Revisiting new variant famine: the case of Swaziland by Scott Naysmith & Alex Waal & Alan Whiteside [Downloadable! (restricted)] 261-269 Food prices and the HIV response: findings from rapid regional assessments in eastern and southern Africa in 2008[InlineMediaObject not available: see fulltext.][InlineMediaObject not available: see fulltext.] by Stuart Gillespie & Paul Jere & John Msuya & Scott Drimie [Downloadable! (restricted)] 271-289 Declining global per capita agricultural production and warming oceans ...

105

Hypersersensitivity and Kounis syndrome due to a viper bite  

British Library Electronic Table of Contents (United Kingdom)

A 60-year-old male was bitten by a venomous snake (Vipera ammodytes) and gradually developed signs of an allergic reaction including generalized itching, generalized rash, and chest discomfort. This was followed by severe retrosternal pain with electrocardiographic evidence of an inferior myocardial ischemia progressing to acute myocardial infarction. Cardiac enzymes and troponin, serum tryptase, and histamine were elevated. Coronary arteriography showed normal coronary arteries. This is a characteristic type I variant of Kounis syndrome, which is the concurrence of acute coronary syndromes with conditions associated with mast cell activation including allergic or hypersensitivity reactions as well as anaphylactic or anaphylactoid reactions. This is the first report to show that viper bite...

2006-01-01

106

Generalized Tonnetze  

British Library Electronic Table of Contents (United Kingdom)

We study a generalization of the classical Riemannian Tonnetz to N-tone equally tempered scales (for all N) and arbitrary triads. We classify all the spaces that result. The torus turns out to be the most common possibility, especially as N grows. Other spaces include 2-simplices, tetrahedra boundaries, and the harmonic strip (in both its cylinder and Mobius band variants). The final and most exotic space we find is something we call a 'circle of tetrahedra boundaries'. These are the Tonnetze for spaces of triads which contain a tritone. They are closely related to Peck's Klein bottle Tonnetz.

2011-01-01

107

GIT Constructions of Moduli Spaces of Stable Curves and Maps  

CERN Document Server

This largely expository paper first gives an introduction to Hilbert stability and its use in Gieseker's GIT construction of $\\overline{M}_g$. Then I review recent work in this area--variants for unpointed curves that arise in Hassett's log minimal model program, starting with Schubert's moduli space of pseudostable curves, and constructions for weighted pointed stable curves and for pointed stable maps due to Swinarski and to Baldwin and Swinarski respectively. The focus is on the steps at which new ideas are needed. Finally, I list open problems in the area, particularly some arising in the log minimal model program that seem inaccessible to current techniques.

2008-01-01

108

Enzymatic synthesis of N- and O-linked glycopeptides  

Energy Technology Data Exchange (ETDEWEB)

This paper describes the study of kinetically controlled enzymatic coupling of N- and O-glycopeptide fragments using subtilisin BPN' and two of its variants developed for use in high concentrations of dimethylformamide and in aqueous solution, respectively. Glycosyl amino acids were exploited as the P[sub 1], P[sub 2], P[sub 3], P'[sub 1], P'[sub 2], or P'[sub 3] residue in the enzymatic coupling. Glycosyltransferase-mediated glycosylation of the glycopeptide fragments obtained prior to or after enzymatic peptide bond formation is demonstrated. 19 refs., 5 figs., 1 tab.

1993-07-14

109

Cubature Kalman smoothers  

British Library Electronic Table of Contents (United Kingdom)

The cubature Kalman filter (CKF) is a relatively new addition to derivative-free approximate Bayesian filters built under the Gaussian assumption. This paper extends the CKF theory to address nonlinear smoothing problems; the resulting state estimator is named the fixed-interval cubature Kalman smoother (FI-CKS). Moreover, the FI-CKS is reformulated to propagate the square-root error covariances. Although algebraically equivalent to the FI-CKS, the square-root variant ensures reliable implementation when committed to embedded systems with fixed precision or when the inference problem itself is ill-conditioned. Finally, to validate the formulation, the square-root FI-CKS is applied to track a ballistic target on reentry.

2011-01-01

110

Correlation between tensile property and micro-hardness in reduced activation ferritic/martensitic steel irradiated at 573 K  

International Nuclear Information System (INIS)

Full text of publication follows: Radiation hardening and embrittlement due to high-energy neutron radiation around 623 K are the important issues on reduced-activation ferritic/martensitic (RAF/M) steels. It is expected that the improvement of radiation hardening might be one of effective ways to control the mechanical properties of RAF/M after irradiation. It has been reported that the weld joint has less hardening than the base metal from the tensile test results of TIG weldments irradiated in HFIR. This report indicated that radiation hardening can be reduced by the optimization of heat treatment condition for F82H. The purposes of this study are to establish the condition of heat treatment for minimum of radiation hardening in F82H steel using Neutron/Ion-irradiation and to examine a correlation between tensile property and micro-hardness before/after irradiation. The materials used in this study were F82H IEA heat and F82H heat treatment variants. Neutron ...

2007-12-10

111

Testing and modification of a simple flow turbine; Messtechnische Untersuchung und Modifikation einer einfachen Durchstroemturbine  

Energy Technology Data Exchange (ETDEWEB)

A study conducted at the IHS had the aim to obtain basic information on whether it is possible to build flow turbines following the free jet principle that are on a par with, or superior to, the conventional design, especially in terms of performance and the efficiency curve. Several inflow contours with a ventilated free jet and a conventional flow turbine were studied. The direct comparison of these variants revealed a slightly enhanced peak load efficiency and a very distinct superiority of the free jet contour during partial load. But the efficiency of all variants failed to attain the values claimed by commercial manufacturers. As compared to the initial contour, peak load efficiency was enhanced by 5 per cent. During partial load, the variants studied showed a distinct superiority of the free jet concept over the contour of conventional flow turbines. (orig.) [Deutsch] Am IHS wurde eine Untersuchung mit dem Ziel ...

1997-12-31

112

The Detection of Pressure Fluctuations, Sonic Audition, Is the Dominant Mode of Dipole-Source Detection in Goldfish (Carassius auratus)  

UK PubMed Central (United Kingdom)

Behavioral detection of a low-frequency (40 Hz) vibratory dipole at source distances of 1.5–24 cm was measured by classically conditioned respiratory suppression in goldfish (Carassius...Full Text Available

2009-04-01

113

Early detection of bone metastases of Ewing's sarcoma by magnetic resonance imaging  

International Nuclear Information System (INIS)

Bone metastases of an Ewing's sarcoma were detected by magnetic resonance imaging (MRI), when bone scan, CT and plain films were still normal. This is due to the ability of MRI to detect intramedullary metastases before involvement of the cortex. (Auth.).

114

Detection and Toxin Typing of Clostridium perfringens in Formalin-Fixed, Paraffin-Embedded Tissue Samples by PCR?  

UK PubMed Central (United Kingdom)

Since current microbiology methods are not suitable to detect Clostridium perfringens in formalin-fixed, paraffin-embedded tissue samples, we developed a PCR assay to detect toxin-encoding...Full Text Available

2009-03-01

115

Detection and Identification of Ciprofloxacin-Resistant Yersinia pestis by Denaturing High-Performance Liquid Chromatography  

UK PubMed Central (United Kingdom)

Denaturing high-performance liquid chromatography (DHPLC) has been used extensively to detect genetic variation. We used this method to detect and identify Yersinia pestis KIM5 ciprofloxacin-resistant...Full Text Available

2003-07-01

116

Radionuclide X-ray fluorescence analysis. 2: Detection of the X-ray fluorescence radiation excited by radionuclide radiation  

Science.gov (United States)

This investigation describes the technique for the detection of the X-ray fluorescent radiation

1972-01-01

117

Integration of Microdialysis Sampling and Microchip Electrophoresis with Electrochemical Detection  

UK PubMed Central (United Kingdom)

Here we describe the fabrication, optimization, and application of a microfluidic device that integrates microdialysis (MD) sampling, microchip electrophoresis (ME), and electrochemical detection...Full Text Available

2008-12-01

118

Direct Detection Optical Intersatelllte Link at 220 Mbps Using ...  

Science.gov (United States)

on this technology has beenproposedas a payload on SpaceStation Freedom to be launched in the near future [1]. Direct detection 4-ary pulse position modula- ...

119

Development of a universal plate-agglutination test for detecting Haemophilus parasuis  

UK PubMed Central (United Kingdom)

Due to the serovar diversity in Haemophilus (H.) parasuis, it is difficult to develop a universal serological method for detection of this pathogen....Full Text Available

2010-12-01

120

Detection of Microcalcification in Mammograms Using Wavelet Transform and Fuzzy Shell Clustering  

CERN Document Server

Microcalcifications in mammogram have been mainly targeted as a reliable earliest sign of breast cancer and their early detection is vital to improve its prognosis. Since their size is very small and may be easily overlooked by the examining radiologist, computer-based detection output can assist the radiologist to improve the diagnostic accuracy. In this paper, we have proposed an algorithm for detecting microcalcification in mammogram. The proposed microcalcification detection algorithm involves mammogram quality enhancement using multirresolution analysis based on the dyadic wavelet transform and microcalcification detection by fuzzy shell clustering. It may be possible to detect nodular components such as microcalcification accurately by introducing shape information. The effectiveness of the proposed algorithm for microcalcification ...

2010-01-01

121

Detecting Airborne Mercury by Use of Palladium Chloride Detecting ...  

Science.gov (United States)

Palladium chloride films have been found to be useful as ... when suitably prepared palladium chlo- ride films are exposed ... Like the palladium chloride ( PdCl2) ...

122

Color Fluorescence Ratio for Detection of Bronchial Dysplasia and Carcinoma In situ  

UK PubMed Central (United Kingdom)

BackgroundAutofluorescence bronchoscopy is more sensitive than conventional bronchoscopy for detecting early airway mucosal lesions. Decreased specificity can lead...Full Text Available

2009-07-15

123

Variational method for estimating the rate of convergence of Markov Chain Monte Carlo algorithms  

CERN Document Server

We demonstrate the use of a variational method to determine a quantitative lower bound on the rate of convergence of Markov Chain Monte Carlo (MCMC) algorithms as a function of the target density and proposal density. The bound relies on approximating the second largest eigenvalue in the spectrum of the MCMC operator using a variational principle and the approach is applicable to problems with continuous state spaces. We apply the method to one dimensional examples with Gaussian and quartic target densities, and we contrast the performance of the basic Metropolis-Hastings algorithms with a ``smart'' variant that incorporates gradient information into the trial moves. We find that the variational method agrees quite closely with numerical simulations. We also see that the smart MCMC algorithm often fails to converge geometrically in the tails of the target density except in the simplest case we examine, and even then care must be taken to choose the appropriate ...

2006-01-01

124

Twinning mechanism in PrCo_2C_x magnetic phase  

International Nuclear Information System (INIS)

A magnetic rhombohedral PrCo_2C_x (x = 0.05 #approx#0.25) phase (space group Rbar 3m), which is heavily twinned along the #left brace#110#right brace# and #left brace#211#right brace# planes, was identified. The twinning mechanism was explored by analyzing the reduction of crystal symmetry due to the cubic-rhombohedral phase transformation. The origin of the twinning and the formation of four twin variants were attributed to the insertion of carbon interstitials into Co_4 tetrahedrons along the bar 3 axis in the rhombohedral lattice, which corresponds to one of the four equivalent axes of its parent PrCo_2 cubic-lattice.

1997-04-04

125

Thermal performance study for the coal-fired combined cycle with partial gasification and fluidized bed combustion  

Energy Technology Data Exchange (ETDEWEB)

The coal-fired combined cycle with partial gasification and fluidized bed combustion (PGFBC-CC), also referred to as a hybrid cycle, has advantages of staged energy conversion and utilization, which can attain high thermal efficiency with low emissions. Four kinds of PGFBC-CC are studied in this paper, two based on pressurized fluidized bed combustion (PFBC) and two on atmospheric fluidized bed combustion (AFBC). Thermal performance calculations and parametric analyses were performed. On the basis of the results, from the above analyses, the best integration system for China is suggested. In addition, a preliminary exergetic analysis is carried out for three of the PGFBC-CC variants.

2001-07-01

126

The cost effectiveness of cognitive behavioral therapy for bulimia nervosa delivered via telemedicine versus face-to-face  

British Library Electronic Table of Contents (United Kingdom)

Objective A number of effective treatments for bulimia nervosa have been developed, but they are infrequently used, in part due to problems with dissemination. The goal of this study was to examine the cost effectiveness of telemedicine delivery of cognitive behavioral therapy for bulimia nervosa. Method A randomized controlled trial of face-to-face versus telemedicine cognitive behavioral therapy for bulimia nervosa. One hundred twenty eight women with DSM-IV bulimia nervosa or eating disorder, not otherwise specified subsyndromal variants of bulimia nervosa were randomized to 20 sessions of treatment over 16 weeks. A cost effectiveness analysis from a societal perspective was conducted. Results The total cost per recovered (abstinent) subject was $9324.68 for face-to-face CBT, and $7300....

2009-01-01

127

The contribution of lower vertebrate animal models in human reproduction research  

British Library Electronic Table of Contents (United Kingdom)

Many advances have been carried out on the estrogens, GnRH and endocannabinoid system that have impact in the reproductive field. Indeed, estrogens, the generally accepted female hormones, have performed an unsuspected role in male sexual functions thanks to studies on non-mammalian vertebrates. Similarly, these animal models have provided important contributions to the identification of several GnRH ligand and receptor variants and their possible involvement in sexual behavior and gonadal function regulation. Moreover, the use of non-mammalian animal models has contributed to a better comprehension about the endocannabinoid system action in several mammalian reproductive events. We wish to highlight here how non-mammalian vertebrate animal model research contributes to advancements with i...

2011-01-01

128

The Physics of Cosmic Acceleration  

CERN Document Server

The discovery that the cosmic expansion is accelerating has been followed by an intense theoretical and experimental response in physics and astronomy. The discovery implies that our most basic notions about how gravity work are violated on cosmological distance scales. One simple fix is the introduction of a cosmological constant into the field equations for general relativity. However, the extremely small value of the cosmological constant, relative to theoretical expectations, has led theorists to explore a wide variety of alternative explanations that involve the introduction of an exotic negative-pressure fluid or a modification of general relativity. Here we briefly review the evidence for cosmic acceleration. We then survey some of the theoretical attempts to account for it, including the cosmological constant, quintessence and its variants, mass-varying neutrinos, and modifications of general relativity, such as scalar-tensor and $f(R)$ theories and ...

2009-01-01

129

Study of questions of reliability of planning mining operations at open pits  

Energy Technology Data Exchange (ETDEWEB)

A method is proposed for evaluating reliability of planning and calculation of the reliability factor with current planning of open pit mining operations. For a quantitative evaluation of the reliability of fulfilling the planned assignment, laws were defined for distribution of the quality characteristics of the coal. After establishing that coal ash content follows the normal distribution law, the probability was defined that the actual output of coal is greater or equal to the planned. Calculation of the factor of reliability of the current planning of open mining operations makes it possible to determine the optimum planning for this period and the probability of fulfillment of the planned assignments. The technique of planning with regard for reliability makes it possible to select the most reliable variant of the plan within the planning period.

1982-01-01

130

Studies on the diagnostic accuracy of lymphography  

International Nuclear Information System (INIS)

Contradictory reports in the literature on the reliability of lymphography stimulated the authors to test the diagnostic accuracy, employing methods which are approximately analogous to practice, using carcinoma of the cervix as the model on which the study was carried out. Using 21 observers it was found that there was no correlation between their experience and on-target accuracy of the diagnosis. Good observers obtained an accuracy of 85% with good proportions between sensitivity in the recognition of detail, specificity and readiness to arrive at a decision on the basis of discriminatory ability. With the help of the concept of the ROC curves, the position taken up by the observers in respect of diagnostic decisions, and a complex manner of assessing the various characteristic factors determining diagnostic accuracy, are demonstrated. This form of test, which permits manipulation of different variants of diagnosis, is recommended, among other things, for ...

131

Structures, Vibrational And Electronic Properties Of (F2O)N (N=2-4) Clusters  

International Nuclear Information System (INIS)

Recently, molecular clusters are the subject of several experimental and computational studies by means of their bonding structures. We studied, first time, small difluorine monoxide clusters such as dimer (linear, cyclic, bifurcated), trimer and tetramer structures using B3LYP variant of density functional theory with cc-pVDZ basis set. On the basis of the optimized geometry, various energy properties such as binding energy, molecular orbital energies, two and three body interaction energies have been calculated. Additionally dipole moment, polarizability, anisotropic polarizability and hyper polarizability have been calculated and compared with monomer structure.

2008-08-25

132

Precipitation behavior and tensile property of the stress-aged Ti-10Mo-8V-1Fe-3.5Al alloy  

British Library Electronic Table of Contents (United Kingdom)

A kind of metastable beta titanium alloy, i.e. Ti-10Mo-8V-1Fe-3.5Al, was aged under elastic compressive stress. Transmission electron microscopy (TEM) investigations revealed that, in the stress-aged samples, precipitated alpha plates were parallel to each other. However, in the conventionally aged samples, alpha plates intersected each other. In other words, variant of alpha plate was selected in the stress-aged samples. Tensile tests showed that, at equivalent tensile strength, the stress-aged samples exhibited higher ductility, compared to the conventionally aged ones.

2011-01-01

133

Non-destructive automated express method for determining the inclination of chromium-nickel steels IGC  

International Nuclear Information System (INIS)

Methods of automated control of 18-10-type steel inclination to IGC are developed and a corresponding automated testing complex (ATS) is created. 08Kh18N10T steel samples had two variants of thermal treatment: 1) 1200 deg (5 h), 600 deg (50 h); 2) 1200 deg (5 h). Methods of non-destructive automated control of 18-10-type steel inclination to IGC are developed on the basis of potentiodynamic reactivation (PR) principle. Automated testing complex is developed, which has undergone experimental running and demonstrated a high confidence of results, reliability and easy operation.

1986-01-01

134

Microcystins Induce Morphological and Physiological Changes in Selected Representative Phytoplanktons  

British Library Electronic Table of Contents (United Kingdom)

Dissolved microcystins (MCs) are regularly present in water dominated by microcystin-producing, bloom-forming cyanobacteria. In vitro experiments with environmentally feasible concentrations (5 ? 10?7 M) of the three most common microcystins, MC-LR, MC-RR, and MC-YR, revealed that they influence the metabolism of different representative phytoplanktons. At light intensities that are close to the cyanobacterial bloom environment (50??mol m?2 s?1), they produce morphological and physiological changes in both microcystin-producing and -nonproducing Microcystis aeruginosa strains and also have similar effects on the green alga Scenedesmus quadricauda that is frequently present in cyanobacterial blooms. All three microcystin variants tested induce cell aggregation, increase in cell volume, and ...

2006-01-01

135

MA28: a set of Fortran subroutines for sparse unsymmetric linear equations. Revision  

Energy Technology Data Exchange (ETDEWEB)

In this report we present a suite of subroutines for the solution of sparse unsymmetric sets of linear equations using a variant of Gaussian elimination. The subroutines are divided into three distinct phases. The first phase optionally preorders the matrix to block triangular form and then performs a sparsity oriented factorization, the second factorizes a matrix of a similar sparsity pattern, while the third uses these decompositions to solve the equations. In this revised edition, the actual Fortran listings have been replaced by a reference to their availability in machine readable form. Other changes to the first edition are minor. This revision is essentially a reprint of the 1979 revision, the only changes being that the MA28A specification sheet has been typeset and has a few minor changes and the existence of a version of the package for complex equations is announced. 11 refs., 11 tabs.

1980-11-01

136

Introduction to the Special Issue: Human Linkage Studies for Behavioral Traits  

British Library Electronic Table of Contents (United Kingdom)

In the post Genome era, the aim of behavior genetics has shifted from estimating the relative contributions of genes and environmental factors to (co-)variation in human complex traits, to localization of genes and identification of functional genetic variants. This special issue reflects this transition and presents fifteen papers that report on genome-wide linkage scans for complex traits in humans and on methodological tools and innovations. Six papers focus on cognition and report overlapping linkage peaks on chromosomes 6p and 14p. Papers on addictive behavior, i.e. smoking and alcohol dependence and its endophenotypes, find moderate LOD scores on chromosomes 6p, 5q, 4p and 7q, respectively. Three papers concentrate on emotionality, depression and loneliness and examine chromosomes 2q...

2006-01-01

137

Importance of the Adrenal Gland Blood Supply During Laparoscopic Subtotal Adrenalectomy  

British Library Electronic Table of Contents (United Kingdom)

Abstract Introduction: Laparoscopic subtotal adrenalectomy (LSA) has emerged as a treatment option in the management of certain adrenal pathologies. After LSA, a satisfactory blood supply to the adrenal remnant is vital to preserve steroid function. The aim of this study was to review the adrenal blood supply with relevance to LSA. Materials and Methods: The adrenal blood supply was examined in three ways: 1) a review of six previous cadaver studies looking at adrenal blood supply; 2) a review of our 164 consecutive laparoscopic adrenalectomies (LAs) (January 1999?January 2009); the details of the main adrenal veins and variants had been prospectively recorded; and 3) dissection of 4 cadaver specimens (macroscopic and histologic examination was performed). Results: The six cadaver studies ...

2010-01-01

138

Global Existence of Weak Solutions to a Nonlocal Cahn-Hilliard-Navier-Stokes System  

CERN Document Server

A well-known diffuse interface model consists of the Navier-Stokes equations nonlinearly coupled with a convective Cahn-Hilliard type equation. This system describes the evolution of an incompressible isothermal mixture of binary-fluids and it has been investigated by many authors. Here we consider a variant of this model where the standard Cahn-Hilliard equation is replaced by its nonlocal version. More precisely, the gradient term in the free energy functional is replaced by a spatial con- volution operator acting on the order parameter phi. Therefore the coupling with the Navier-Stokes equations is difficult to handle even in two spatial dimensions because of the lack of regularity of phi. We establish the global existence of a weak solution.

2011-01-01

139

Genome-wide association study identifies variants in the CFH region associated with host susceptibility to meningococcal disease  

British Library Electronic Table of Contents (United Kingdom)

Meningococcal disease is an infection caused by Neisseria meningitidis. Genetic factors contribute to host susceptibility and progression to disease, but the genes responsible for disease development are largely unknown. We report here a genome-wide association study for host susceptibility to meningococcal disease using 475 individuals with meningococcal disease (cases) and 4,703 population controls from the UK. We performed, in Western European and South European cohorts (consisting of 968 cases and 1,376 controls), two replication studies for the most significant SNPs. A cluster of complement factor SNPs replicated independently in both cohorts, including SNPs within complement factor H (CFH) (rs1065489 (p.936D

2010-01-01

140

Genetic fidelity of long-term micropropagated shoot cultures of vanilla (Vanilla planifolia Andrews) as assessed by molecular markers  

British Library Electronic Table of Contents (United Kingdom)

Occurrence of genetic variants during micropropagation is occasionally encountered when the cultures are maintained in vitro for long period. Therefore, the micropropagated multiple shoots of Vanilla planifolia Andrews developed from axillary bud explants established 10 years ago were used to determine somaclonal variation using random amplified polymorphic DNA (RAPD) and intersimple sequence repeats markers (ISSR). One thousand micro-plants were established in soil of which 95 plantlets (consisting of four phenotypes) along with the mother plant were subjected to genetic analyses using RAPD and ISSR markers. Out of the 45 RAPD and 20 ISSR primers screened, 30 RAPD and 7 ISSR primers showed 317 clear, distinct and reproducible band classes resulting in a total of 30 115 bands. However, no ...

2007-01-01

141

GFAP in health and disease  

British Library Electronic Table of Contents (United Kingdom)

Glial fibrillary acidic protein (GFAP) is the main intermediate filament protein in mature astrocytes, but also an important component of the cytoskeleton in astrocytes during development. Major recent developments in astrocyte biology and the discovery of novel intermediate filament functions enticed the interest in the function of GFAP. The discovery of various GFAP splice variants gave an additional boost to explore this protein in more detail.The structural role of GFAP in astrocytes has been widely accepted for a long time, but over the years, GFAP has been shown to be involved in astrocyte functions, which are important during regeneration, synaptic plasticity and reactive gliosis. Moreover, different subpopulations of astrocytes have been identified, which are likely to have distinc...

2011-01-01

142

Fente mediane cervicomaxillaire inferieure : a propos d'un cas, mise au point ethiopathogenique et therapeutique  

British Library Electronic Table of Contents (United Kingdom)

Introduction: The orofacial clefts include 30 variant according to Tessier classification: the number 30 contain mandibular arc damage isolated or associated with damage of surrounding soft tissue. Case report: Our patient was a newborn with median mandibular cleft associated with ankyloglossia, bifid tongue and a top cervical fistula. We have not found polymalformative syndrome. The early surgical management included one time and after-effect were simple within 11months. Discussion: We point up difficulties for antenatal diagnosis and controversy about appropriate time for management of bone defect. The last physiopathologic hypotheses were explicated.

2011-01-01

143

Experimental Comparison of Representation Methods and Distance Measures for Time Series Data  

CERN Document Server

The previous decade has brought a remarkable increase of the interest in applications that deal with querying and mining of time series data. Many of the research efforts in this context have focused on introducing new representation methods for dimensionality reduction or novel similarity measures for the underlying data. In the vast majority of cases, each individual work introducing a particular method has made specific claims and, aside from the occasional theoretical justifications, provided quantitative experimental observations. However, for the most part, the comparative aspects of these experiments were too narrowly focused on demonstrating the benefits of the proposed methods over some of the previously introduced ones. In order to provide a comprehensive validation, we conducted an extensive experimental study re-implementing eight different time series representations and nine similarity measures and their variants, and testing their effectiveness on ...

2010-01-01

144

Disordered bcc γ-phase to δ-phase transformation in Zr-rich U-Zr alloy  

British Library Electronic Table of Contents (United Kingdom)

The transformation mechanism of hexagonal delta phase from the disordered bcc gamma phase has not been reported before in the Zr-rich U-Zr alloy system. With the help of X-ray diffraction, transmission electron microscopy (TEM) and high-resolution TEM analyses it was shown that the gamma to delta conversion takes place by the lattice collapse mechanism of omega transformation. It was also ascertained that a higher aging temperature or time promotes the growth of all four variants of the delta phase within a parent gamma grain. In addition, ab initio electronic structure calculations showed that the bcc to hexagonal transformation, involving partial ordering of the parent bcc phase followed by (111) plane collapse, is energetically favorable.

2011-01-01

145

Crystal structure of the human centromeric nucleosome containing CENP-A  

British Library Electronic Table of Contents (United Kingdom)

In eukaryotes, accurate chromosome segregation during mitosis and meiosis is coordinated by kinetochores, which are unique chromosomal sites for microtubule attachment. Centromeres specify the kinetochore formation sites on individual chromosomes, and are epigenetically marked by the assembly of nucleosomes containing the centromere-specific histone H3 variant, CENP-A. Although the underlying mechanism is unclear, centromere inheritance is probably dictated by the architecture of the centromeric nucleosome. Here we report the crystal structure of the human centromeric nucleosome containing CENP-A and its cognate ?-satellite DNA derivative (147 base pairs). In the human CENP-A nucleosome, the DNA is wrapped around the histone octamer, consisting of two each of histones H2A, H2B, H4 and CENP...

2011-01-01

146

Contribution to 3D-operational geodesy. Pt. 3  

Energy Technology Data Exchange (ETDEWEB)

Whereas in part 1 and 2 the detailed observation equations of terrestrial type for an integrated geodetic model are presented this paper will outline how the theory is transferred in an operational program. The main lines of functions of the FORTRAN IV program are discussed. Since the input specifications as well as the data requirements are described in detail and illustrated by example of input and output part 3 can serve as an user-guide for OPERA. OPERA is an acronym for operational adjustment. Besides the integrated determination of 3D-geocentric coordinates and the gravity disturbing potential the program can handle all cases of traditional geodesy (in total 13 variants of solution are provided) equivalent also with adjustments in ellipsoidal coordinates B, L or H, as well as constrained adjustments, pure prediction of the gravity disturbing field, etc.

1983-01-01

147

Consistency conditions in the chiral ring of super Yang-Mills theories  

CERN Document Server

Starting from the generalized Konishi anomaly equations at the non-perturbative level, we demonstrate that the algebraic consistency of the quantum chiral ring of the N=1 super Yang-Mills theory with gauge group U(N), one adjoint chiral superfield X and N_f<=2N flavours of quarks implies that the periods of the meromorphic one-form Tr dz/(z-X) must be quantized. This shows in particular that identities in the open string description of the theory, that follow from the fact that gauge invariant observables are expressed in terms of gauge variant building blocks, are mapped onto non-trivial dynamical equations in the closed string description.

2007-01-01

148

Concordant Chemical Reaction Networks  

CERN Document Server

We describe a large class of chemical reaction networks, those endowed with a subtle structural property called concordance. We show that the class of concordant networks coincides precisely with the class of networks which, when taken with any weakly monotonic kinetics, invariably give rise to kinetic systems that are injective --- a quality that, among other things, precludes the possibility of switch-like transitions between distinct positive steady states. We also provide persistence characteristics of concordant networks, instability implications of discordance, and consequences of stronger variants of concordance. Some of our results are in the spirit of recent ones by Banaji and Craciun, but here we do not require that every species suffer a degradation reaction. This is especially important in studying biochemical networks, for which it is rare to have all species degrade.

2011-01-01

149

Characterization of All-Chromium Tunnel Junctions and Single Electron Tunneling Devices Fabricated by Direct-Writing Multilayer Technique  

CERN Document Server

We report about the fabrication and analysis of the properties of Cr/CrO_x/Cr tunnel junctions and SET transistors, prepared by different variants of direct-writing multilayer technique. In all cases, the CrO_x tunnel barriers were formed in air under ambient conditions. From the experiments on single junctions, values for the effective barrier height and thickness were derived. For the Cr/CrO_x/Cr SET transistors we achieved minimal junction areas of 17 x 60 nm^2 using a scanning transmission electron microscope for the e-beam exposure on Si_3N_4 membrane substrate. We discuss the electrical performance of the transistor samples as well as their noise behavior.

1999-01-01

150

Cardiac Channelopathies and Sudden Infant Death Syndrome  

British Library Electronic Table of Contents (United Kingdom)

Abstract Sudden infant death syndrome (SIDS) is always a devastating and unexpected occurrence. SIDS is the leading cause of death in the first 6 months after birth in the industrialized world. Since the discovery in 1998 of long QT syndrome as an underlying substrate for SIDS, around 10-20% of SIDS cases have been proposed as being caused by genetic variants in either ion channel or ion channel-associated proteins. Until now, 10 cardiac channelopathy susceptibility genes have been found to be implicated in the pathogenesis of SIDS. Four of the genes encode cardiac ion channel a-subunits, 3 genes encode ion channel b-subunits, and 3 genes encode other channel-interacting proteins. All 10 genes have been associated with primary electrical heart diseases. SIDS may hereby be the initial sympt...

2011-01-01

151

Analysis of the fatigue strength of welded joints produced by different techniques in materials of the type 'alloy 800'  

International Nuclear Information System (INIS)

The alloy type 'alloy 800' with its different variants is used for numerous components in high-temperature reactor (HTR) plants, e.g. for hot-gas conductors, the high-pressure part of steam generators, superheaters, steam collecting vessels and live steam conductors. This study deals with the evaluation of creep rupture tests on 28 welded joints of alloy 800 with an accumulated test duration of 410 years, with the objective to obtain quantitative information on a possible loss of strength in comparison with the unwelded material. The longest test period of an individual test amounted to 98,000 h and the analyzed test temperature range lay between 550"0 and 1000"0C. (orig./MM).

1988-11-25

152

Alloy 800: New stress rupture and creep data for pressurised components in high-temperature reactors  

International Nuclear Information System (INIS)

A new evaluation of the 1% time strain limit for creep strength and the isochronous stress/strain relationship was to be undertaken for the type 800 alloy, based on up to date experimental data. After the evaluation of the 1% time strain limit curves and time fracture curves of individual melts, multilinear regression analyses were made to clear up the relationship between parameters of the creep behaviour such as creep strength, 1% time strain limit and time fracture strain on the one hand and metallurgical parameters such as C, Ti, Al, Ni, Cr contents or grain size and type of manufacture, on the other hand. Based on the knowledge gained from these calculations, new limits were determined for HTR material specifications for variants of the 800 alloy of the Rk, NT, DE, and HT type. (orig./DG).

1988-10-06

153

Alloy 800 specifications in compliance with component requirements  

Energy Technology Data Exchange (ETDEWEB)

In view of the importance of the material Alloy 800 in high-temperature reactor plants (HTR), a material data bank was established which is used for statistical evaluation of mechanical and physical material behaviour. Based on investigations on the interconnection between the mechanical properties at high temperatures and the metallurgical parameters, different types of Alloy 800 were specified in compliance with the component requirements. In addition, aspects of corrosion and toughness behaviour were taken into consideration. The specifications and strength characteristics for the different variants of Alloy 800 were incorporated into draft DIN standards after discussion and approval in expert committees. Further important characteristics of the mechanical and physical material behaviour were summarized in HTR material data sheets so as to furnish an improved basis for the design and stress analyses of Alloy 800 components. (orig.).

1990-04-01

154

Alloy 800 specifications in compliance with component requirements  

International Nuclear Information System (INIS)

In view of the importance of the material Alloy 800 in high-temperature reactor plants (HTR), a material data bank was established which is used for statistical evaluation of mechanical and physical material behaviour. Based on investigations on the interconnection between the mechanical properties at high temperatures and the metallurgical parameters, different types of Alloy 800 were specified in compliance with the component requirements. In addition, aspects of corrosion and toughness behaviour were taken into consideration. The specifications and strength characteristics for the different variants of Alloy 800 were incorporated into draft DIN standards after discussion and approval in expert committees. Further important characteristics of the mechanical and physical material behaviour were summarized in HTR material data sheets so as to furnish an improved basis for the design and stress analyses of Alloy 800 components. (orig.).

155

AFM Imaging of SWI/SNF action: mapping the nucleosome remodeling and sliding  

CERN Document Server

We propose a combined experimental (Atomic Force Microscopy) and theoretical study of the structural and dynamical properties of nucleosomes. In contrast to biochemical approaches, this method allows to determine simultaneously the DNA complexed length distribution and nucleosome position in various contexts. First, we show that differences in the nucleo-proteic structure observed between conventional H2A and H2A.Bbd variant nucleosomes induce quantitative changes in the in the length distribution of DNA complexed with histones. Then, the sliding action of remodeling complex SWI/SNF is characterized through the evolution of the nucleosome position and wrapped DNA length mapping. Using a linear energetic model for the distribution of DNA complexed length, we extract the net wrapping energy of DNA onto the histone octamer, and compare it to previous studies.

2007-01-01

156

A Unified Model for Evolutionary Multiobjective Optimization and its Implementation in a General Purpose Software Framework: ParadisEO-MOEO  

CERN Document Server

This paper gives a concise overview of evolutionary algorithms for multiobjective optimization. A substantial number of evolutionary computation methods for multiobjective problem solving has been proposed so far, and an attempt of unifying existing approaches is here presented. Based on a fine-grained decomposition and following the main issues of fitness assignment, diversity preservation and elitism, a conceptual global model is proposed and is validated by regarding a number of state-of-the-art algorithms as simple variants of the same structure. The presented model is then incorporated into a general-purpose software framework dedicated to the design and the implementation of evolutionary multiobjective optimization techniques: ParadisEO-MOEO. This package has proven its validity and flexibility by enabling the resolution of many real-world and hard multiobjective optimization problems.

2009-01-01

157

A Lamarckian Hybrid of Differential Evolution and Conjugate Gradients for Neural Network Training  

British Library Electronic Table of Contents (United Kingdom)

The paper describes two schemes that follow the model of Lamarckian evolution and combine differential evolution (DE), which is a population-based stochastic global search method, with the local optimization algorithm of conjugate gradients (CG). In the first, each offspring is fine-tuned by CG before competing with their parents. In the other CG is used to improve both parents and offspring in a manner that is completely seamless for individuals that survive more than one generation. Experiments involved training weights of feed-forward neural networks to solve three synthetic and four real-life problems. In six out of seven cases the DE?CG hybrid, which preserves and uses information on each solution?s local optimization process, outperformed two recent variants of DE.

2010-01-01

160

Theoretical review of techniques for the remote detection of methane in underground coal mines  

Energy Technology Data Exchange (ETDEWEB)

The nature and relationship of methane to coal mines is discussed and sources of information are outlined. Methods of gas analysis in general and methods for the detection of methane in use in coal mines are described. Methods of remote detection of gases and those that have application for use in underground coal mining operations are discussed. The report represents recommendations on remote methane detection systems that may find application in underground coal mines. (20 refs.)

1983-01-01

165

Isolation and Identification of Mycoplasmas  

International Science & Technology Center (ISTC)

Isolation and Identification of Mycoplasmas, Development of Reliable Antigen for Mycoplasmas Detection and Oil-Based Vaccines

166

How the Air Force Should Stay Engaged in Computer Vision ...  

Science.gov (United States)

... 14 Face Detection ..... 14 Automated Mapping ...

2007-04-01

173

Creation of the BioBank, Early Detection and Discovery Biomarkers  

Science.gov (United States)

Pancreatic Cancer; Head and Neck Cancer; Breast Cancer

2011-04-03

178

Infrared radiation features of coal and rocks under loading  

Energy Technology Data Exchange (ETDEWEB)

Samples of fat coal-E, its roof sandstone-A and blind coal-W from two coal mines in Hebei Province of China were brought to the laboratory to study the features of infrared thermal images and radiation temperature in the course of uni-axial load and uni-axial cycle load. To check the results of infrared remote sensing detection, two other methods, acoustic emission detection and electrical resistance detection were also used. The AGA-782 thermalvision detected change of the temperature field of the samples` surfaces. The study showed that: (1) coal rocks and sandstone in the course of loading have three types of infrared thermal image features and three types of infrared radiation temperature features; (2) infrared detection is comparable with acoustic emission detection and electrical resistance detection. Generally, the infrared ...

1998-10-01

179

Slide rings made of an SiC/silicide composite; Gleitringe aus einem SiC/Silicid-Verbundwerkstoff  

Energy Technology Data Exchange (ETDEWEB)

The objective of the project was to develop an infiltration material based on SiC that should have improved corrosion resistance and should permit higher operating temperatures. From a variety of tested doping agents, zirconium silicide and molybdenum proved to be the most appropriate agents. The respective infiltration materials permit a combination of advantages of the SSiC with those of the SiSiC. Silicide SiC, analogous to the SiSiC, is almost nonshrinking, and above all is more corrosion-resistant than SiSiC in the alkaline regime, due to the replacement of free silicon by silicide phases. The operating temperature of the molybdenum-base variant is 1600 C. (orig./CB) [Deutsch] Ziel des Vorhabens war die Entwicklung eines Infiltrationswerkstoffes auf SiC-Basis mit verbesserter Korrosionsbestaendigkeit und hoeherer Einsatztemperatur. Aus einer Vielzahl von getesteten Dotierungsmoeglichkeiten kristallisierten sich Zirkondisilicid und Molybdaen als geeingete ...

1997-12-31

180

Primary structures of four trypsin inhibitor E homologs from venom of Dendroaspis angusticeps: structure-function comparisons with other dendrotoxin homologs.  

Science.gov (United States)

Four trypsin inhibitor homologs, the first known from Dendroaspis angusticeps venom, were characterized using a combination of gel filtration, cation exchange, reverse-phase liquid chromatography, Edman degradation and mass spectrometry. The four toxins comprise two 57 residue and two 59 residue isoforms. The long toxins possess a Lys-Gln N-terminal extension lacked by the short toxins. The only other structural difference is an Arg/His replacement at position 55. The long Arg55 variant is identical to trypsin inhibitor E from the venom of Dendroaspis polylepis. The name epsilon-dendrotoxin is suggested so as to follow the nomenclature of Benishin, C.G., Sorensen, R.G., Brown, W.E., Krueger, B.K., Blaustein, M.P., 1988. Four polypeptide components of green mamba venom selectively block certain potassium channels in rat brain synaptosomes. Mol. Pharmacol. 34, 152-159. Among snake venom protease inhibitors, the epsilon-dendrotoxins are structurally most like the ...

2002-03-01

181

Basic aspects of the concept of reactor compartment (including damaged compartments) management during utilization of nuclear powered submarines -- High priority R and D  

International Nuclear Information System (INIS)

Large-scale decommissioning of Russian nuclear-powered submarines (NPS) and their utilization prospects gave rise to numerous complicated scientific and technical, as well as economic, problems. Problems of handling of radioactive equipment from the reactor compartments (RC) are among the vital ones, arousing a growing concern with the public. Without solution of the problems the processes of NPS utilization can not be considered completed. It involves potential hazard, for the environment both from NPS being paid up (temporal on-float storage) with unloaded spent nuclear fuel (SNF), and RC, cut from submarine hull, containing highly radioactive equipment and materials but no SNF. Diverse variations of the concept of reactor compartment handling of NPS subject to, utilization are possible, but, in principle, there are essentially two variants: (1) RC utilization directly in the course of NPS utilization, envisaging removal of radioactive equipment from the reactor ...

1996-03-10

182

Oil-filled cable surveillance system using newly developed optical fiber gas sensor  

Energy Technology Data Exchange (ETDEWEB)

A new surveillance system for Oil-Filled cable, which can provide continuous monitoring, using a newly developed optical gas sensor that can detect the concentration of the gas dissolved in the oil with extremely high sensitivity has been developed. It was proved that the degree of deterioration of the insulating oil can be detected by measuring C{sub 2}H{sub 2} and CH{sub 4} by investigating the relation between the degree of deterioration and amount of combustible gas generated. In order to detect extremely small amounts of gas, a new gas detecting method using absorption line of the gas using a frequency modulated technique has been developed. The gas detection ability was also confirmed by examination using a 66 kV of cable and the possibility of detection at an early stage is expected.

1996-04-01

183

X-Ray Phase Imaging for Breast Cancer Detection  

Science.gov (United States)

... Accession Number : ADA535309. Title : X-Ray Phase Imaging for Breast Cancer Detection. Descriptive Note : Annual rept. 1 Sep 2009-31 Aug 2010 ...

2010-09-01

184

Wavelet-based Gaussian-mixture hidden Markov model for the detection of multistage seizure dynamics: A proof-of-concept study  

UK PubMed Central (United Kingdom)

BackgroundEpilepsy is a common neurological disorder characterized by recurrent electrophysiological activities, known as seizures. Without the appropriate detection strategies,...Full Text Available

185

Use of an alkaline phosphatase-labeled synthetic oligonucleotide probe for detection of Campylobacter jejuni and Campylobacter coli.  

UK PubMed Central (United Kingdom)

A commercially available synthetic nucleic acid probe (SNAP) conjugated to alkaline phosphatase was compared with standard culture techniques for detecting Campylobacter species. The SNAP was able to...Full Text Available

1990-07-01

186

The possible detection of magnetic monopoles and monopole tachyons  

International Nuclear Information System (INIS)

This paper discusses the possible detection of magnetic monopoles and monopole tachyons. Topics considered include insects, astrophysics, general relativity theory, plants, and biotechnology. The paper was presented at an international symposium on non-conventional energy technology.

187

The Role of the Pattern Edge in Goldfish Visual Motion Detection  

UK PubMed Central (United Kingdom)

To understand the function of edges in perception of moving objects, we defined four questions to answer. Is the focus point in visual motion detection of a moving object: (1) the body or the edge of...Full Text Available

2010-12-01

188

T Plant secondary containment and leak detection upgrades  

Energy Technology Data Exchange (ETDEWEB)

The W-259 project will provide upgrades to the 2706-T/TA Facility to comply with Federal and State of Washington environmental regulations for secondary containment and leak detection. The project provides decontamination activities supporting the environmental restoration mission and waste management operations on the Hanford Site.

1995-10-19

189

Shedding New Light on Early Caries Detection  

UK PubMed Central (United Kingdom)

Dental caries continues to be a common chronic disease among various population groups. Patient care can be improved with detection at the earliest stage. However, current techniques do not...Full Text Available

2008-12-01

190

Satisfaction of Search in Multi-trauma Patients: Severity of Detected Fractures  

UK PubMed Central (United Kingdom)

PurposeSatisfaction of search (SOS) occurs when an abnormality is missed because another abnormality has been detected. This research studied whether the severity...Full Text Available

2007-06-01

191

Rapid Detection of Ophiostoma piceae and O. quercus in Stained Wood by PCR  

UK PubMed Central (United Kingdom)

A rapid, sensitive, and simple method was developed to detect the sapstain fungi Ophiostoma piceae and O. quercus in stained wood. By using microwave heating for DNA...Full Text Available

1999-01-01

192

Rapid Detection of Ofloxacin Resistance in Mycobacterium tuberculosis by Two Low-Cost Colorimetric Methods: Resazurin and Nitrate Reductase Assays  

UK PubMed Central (United Kingdom)

We have evaluated the performance of two rapid, low-cost methods for the detection of ofloxacin (OFX) resistance with 95 Mycobacterium tuberculosis isolates from countries with high...Full Text Available

2005-04-01

193

Processing and microfiltration of mosquitoes for malaria antigen detection in a rapid dot immunobinding assay.  

UK PubMed Central (United Kingdom)

Data on a technique for the detection of antigen from arthropod vectors in a dot immunobinding assay are presented. In this system, antigen present in the vector was first solubilized in sodium dodecyl...Full Text Available

1990-08-01

194

Precise Detection and Tracing of Trichoderma hamatum 382 in Compost-Amended Potting Mixes by Using Molecular Markers  

UK PubMed Central (United Kingdom)

Randomly amplified polymorphic DNA (RAPD) analysis and the PCR assay were used in combination with dilution plating on a semiselective medium to detect and enumerate propagules of Trichoderma...Full Text Available

1999-12-01

195

National Newborn Screening Status Reports  

Science.gov (United States)

... detected (and reported) as a by-product of MRM screening (MS/MS) targeted by Law or Rule ... detected (and reported) as a by-product of MRM screening (MS/MS) targeted by Law or Rule ...

196

Latex immunoassay for rapid detection of rotavirus.  

UK PubMed Central (United Kingdom)

A latex agglutination (LA) test was evaluated for the detection of human rotaviruses in stool specimens. Both antiserum and immunoglobulin G (IgG)-sensitized latex particles were used, with IgG-coated...Full Text Available

1984-09-01

197

Immunoquantitative Real-Time PCR for Detection and Quantification of Staphylococcus aureus Enterotoxin B in Foods  

UK PubMed Central (United Kingdom)

A real-time immunoquantitative PCR (iqPCR) method for detection of Staphylococcus aureus enterotoxin B (SEB) was developed and evaluated using both pure cultures and foods. The assay...Full Text Available

2006-10-01

198

Immunochemical detection of glycated lens crystallins and their circulating autoantibodies in human serum during aging  

UK PubMed Central (United Kingdom)

PurposeThe aim of this investigation was to exploit lens-specific glycated crystallins as an immunogen to detect human glycated crystallins and their circulating autoantibodies in...Full Text Available

199

Heart Rate Characteristics: Physiomarkers for Detection of Late-Onset Neonatal Sepsis  

UK PubMed Central (United Kingdom)

SynopsisEarly detection of late onset neonatal sepsis, prior to obvious and potentially catastrophic clinical signs, is an important goal in neonatal medicine. Sepsis causes a...Full Text Available

2010-09-01

200

Genome-wide detection and characterization of positive selection in human populations  

UK PubMed Central (United Kingdom)

With the advent of dense maps of human genetic variation, it is now possible to detect positive natural selection across the human genome. Here we report an analysis of over 3 million polymorphisms...Full Text Available

2007-10-18

201

Generation of Novel Bacterial Regulatory Proteins That Detect Priority Pollutant Phenols  

UK PubMed Central (United Kingdom)

The genetic systems of bacteria that have the ability to use organic pollutants as carbon and energy sources can be adapted to create bacterial biosensors for the detection of industrial pollution....Full Text Available

2000-01-01

202

Experimental studies on a structure of eddy current probe for detection of magnetic flux disturbed by a flaw  

International Nuclear Information System (INIS)

Bobbin-coil-type eddy current probes, which are conventionally used for nondestructive inspection of steam generator tubes in pressurized-water-type nuclear power plants, have poor detectability for circumferential flaws. Hence a new type of eddy current probe was proposed to detect effectively the magnetic flux component disturbed by a flaw and thus to eliminate the flaw direction dependency on the flaw detectability. In the course of development of the proposed method, structures of the probe were investigated based on the measurement of magnetic fields induced by exciting flat coils with several shapes. The new type of probe proposed here consists of differential pick-up coils detecting magnetic flux and exciting coils having a parallelogrammic shape, and its structure was fabricated experimentally in order to detect flaws independently of their directions. Nondestructive flaw ...

1995-01-01

203

Evaluation of the microparticle enzyme immunoassay Abbott IMx Select Chlamydia and the importance of urethral site sampling to detect Chlamydia trachomatis in women.  

UK PubMed Central (United Kingdom)

OBJECTIVE: To evaluate the commercial microparticle enzyme immunoassay (MEIA), Abbott IMx Select Chlamydia, for the detection of Chlamydia trachomatis in women and to compare its performance with endocervical...Full Text Available

1997-12-01

204

Evaluation of a New Chromogenic Medium, MRSA Select, for Detection of Methicillin-Resistant Staphylococcus aureus?  

UK PubMed Central (United Kingdom)

We compared MRSA Select to mannitol-salt agar with 8 μg/ml cefoxitin for the detection of methicillin-resistant Staphylococcus aureus (MRSA) from 6,199 clinical...Full Text Available

2006-12-01

205

Evaluation of Direct Detection of Mycobacterium tuberculosis Rifampin Resistance by a Nitrate Reductase Assay Applied to Sputum Samples in Cotonou, Benin?  

UK PubMed Central (United Kingdom)

The aim of this study was to evaluate a nitrate reductase assay (NRA) performed on smear-positive sputa for the direct detection of rifampin resistance in Mycobacterium tuberculosis....Full Text Available

2007-07-01

206

Evaluation of Colorimetric Methods Using Nicotinamide for Rapid Detection of Pyrazinamide Resistance in Mycobacterium tuberculosis?  

UK PubMed Central (United Kingdom)

The direct detection of pyrazinamide resistance in Mycobacterium tuberculosis is sufficiently difficult that many laboratories do not attempt it. Most pyrazinamide resistance is caused...Full Text Available

2010-08-01

207

Enzyme amplified immunoassay: a novel technique applied to direct detection of Chlamydia trachomatis in clinical specimens.  

UK PubMed Central (United Kingdom)

Endocervical swabs from 212 women and urethral swabs from 100 men were tested by the routine methods for McCoy cell culture and simultaneously by a novel enzyme amplified immunoassay test to detect...Full Text Available

1985-10-01

208

Discovery of interstellar rubidium  

Energy Technology Data Exchange (ETDEWEB)

We have discovered interstellar rubidium by observing the resonance line of Rb I at 7800 A toward zeta Oph. This is the heaviest element yet detected within the interstellar medium, and our detection of this element is important for understanding the history of nucleosynthesis in the solar neighborhood.

1981-12-01

209

Diarrheal Illness Detected Through Syndromic Surveillance After a Massive Power Outage: New York City, August 2003  

UK PubMed Central (United Kingdom)

Objectives. We investigated increases in diarrheal illness detected through syndromic surveillance after a power outage in New York City on August 14, 2003.Methods....Full Text Available

2006-03-01

210

Diagnosis of Plasmodium falciparum infection using a solid-phase radioimmunoassay for the detection of malaria antigens  

UK PubMed Central (United Kingdom)

A serodiagnostic test has been developed for the detection of Plasmodium falciparum in infected blood. Using parasite antigens and infected red blood cells from in vitro...Full Text Available

1980-01-01

211

Detection of rotavirus by serological trapping on antibody-coated electron microscope grids.  

UK PubMed Central (United Kingdom)

A serological trapping technique for detecting rotaviruses is described which involves coating electron microscope grids with protein A and specific rotavirus antiserum. The presence of a layer of antibodies...Full Text Available

1980-07-01

212

Detection of cellular responses to toxicants by dielectrophoresis  

UK PubMed Central (United Kingdom)

The dielectrophoretic (DEP) crossover method has been applied to the detection of cell responses to toxicants. Time and dose responses of the human cultured leukemia (HL-60) line were measured...Full Text Available

2002-08-31

213

Detection of an arbuscular mycorrhizal fungus in roots of different plant species with the PCR.  

UK PubMed Central (United Kingdom)

PCR was used with the primer pair VANS1-NS21 to detect the arbuscular mycorrhizal fungus Glomus intraradices (commercial inoculum source) on roots of lettuce, zinnia, leek, pepper, and endive plants....Full Text Available

1995-07-01

214

Detection of Ockelbo virus RNA in skin biopsies by polymerase chain reaction.  

UK PubMed Central (United Kingdom)

A sensitive assay based on the polymerase chain reaction for the detection of Ockelbo virus RNA was developed. Two primer pairs from the gene coding for the E2 glycoprotein were chosen. By use of a...Full Text Available

1993-08-01

215

Detection and enumeration of toxin-producing Pasteurella multocida with a colony-blot assay.  

UK PubMed Central (United Kingdom)

Colonies of toxin-producing Pasteurella multocida were detected with peroxidase-labeled monoclonal antibodies by a membrane assay. Examination of the specificity of the assay with 29 P. multocida cultures...Full Text Available

1991-07-01

216

Detection and classification of bearing flaking using kullback discrimination information; Kullback shikibetsu johoryo (KDI) wo mochiita jikuuke no tendomen hakuri no kenchi to shikibetsu  

Energy Technology Data Exchange (ETDEWEB)

Since bearing is in wide use as basic parts for rotary machines, detection and diagnosis of its defects are important in practical use. To discriminate defect portions by early detection of roller bearing flaking, the conventional parameter method using peakedness is poor. Thus to directly obtain difference in waveform, the new method was applied to such detection which uses KDI as the scale of a difference in waveform, and a most neighborhood classification rule based on KDI. The detection and discrimination abilities of this method was studied mainly in experiment. The experiment used a bench scale rotor and a supporting bearing, and attempted detection and discrimination of no flaking, outer ring flaking and inner ring flaking. As a result, this method could detect and discriminate fine flaking which was never detected by conventional ...

1998-06-15

217

Detection and Differentiation of Cryptosporidium spp. in Human Clinical Samples by Use of Real-Time PCR?  

UK PubMed Central (United Kingdom)

Real-time PCR has the potential to streamline detection and identification of Cryptosporidium spp. in human clinical samples. In the present...Full Text Available

2011-03-01

218

DNA alterations detected in the progeny of paternally irradiated Japanese medaka fish (Oryzias latipes).  

UK PubMed Central (United Kingdom)

A nonmammalian test system for germ-cell mutagenesis has been developed by using the Japanese medaka fish. We describe a system for detecting DNA alterations in F1 progeny descended from the gamma-irradiated...Full Text Available

1995-01-03

219

Clinical Significance of the Detection of Antinuclear Antibodies in Patients with Acute Hepatitis A  

UK PubMed Central (United Kingdom)

Background/AimsThe findings of several recent studies suggest that antinuclear antibodies (ANAs) are frequently detected in patients with acute hepatitis A (AHA). However, the clinical...Full Text Available

2011-09-01

220

Cavity detection by the electric method: the 3-dimensional case  

Energy Technology Data Exchange (ETDEWEB)

In this paper the authors prove a uniqueness theorem for the electric detection of cavities in a three dimensional solid from Cauchy data measured on the surface. The cavities, finite in number, are assumed to be insulating. The surfaces of the cavities are assumed to be smooth on the complement of a set that is, in some sense, negligible. (orig.)

2004-02-01

221

Assessment of 1183 screen-detected, category 3B, circumscribed masses by cytology and core biopsy with long-term follow up data  

UK PubMed Central (United Kingdom)

Discrete masses are commonly detected during mammographic screening and most such lesions are benign. For lesions without pathognomonically benign imaging features that are still regarded likely to...Full Text Available

2008-04-08

222

Application of an indirect immunofluorescence test for detection of Mycoplasma pneumoniae in respiratory exudates.  

UK PubMed Central (United Kingdom)

We prepared polyclonal antibody specific to Mycoplasma pneumoniae and examined the conditions influencing the ability of an indirect immunofluorescence test to detect the specific antigen in respiratory...Full Text Available

1991-09-01

223

Analysis of the Type IV Fimbrial-Subunit Gene fimA of Xanthomonas hyacinthi: Application in PCR-Mediated Detection of Yellow Disease in Hyacinths  

UK PubMed Central (United Kingdom)

A sensitive and specific detection method was developed for Xanthomonas hyacinthi; this method was based on amplification of a subsequence of the type IV fimbrial-subunit gene fimA...Full Text Available

2001-02-01

224

Age-Stratified Bayesian Analysis To Estimate Sensitivity and Specificity of Four Diagnostic Tests for Detection of Cryptosporidium Oocysts in Neonatal Calves?  

UK PubMed Central (United Kingdom)

There is no gold standard diagnostic test for the detection of bovine cryptosporidiosis. Infection is usually highest in 2-week-old calves, and these calves also excrete high numbers of oocysts. These...Full Text Available

2011-01-01

225

A novel custom high density-comparative genomic hybridization array detects common rearrangements as well as deep intronic mutations in dystrophinopathies  

UK PubMed Central (United Kingdom)

BackgroundThe commonest pathogenic DMD changes are intragenic deletions/duplications which make up to 78% of all cases and point mutations (roughly 20%) detectable...Full Text Available

226

A faster pedigree-based generalized multifactor dimensionality reduction method for detecting gene-gene interactions  

UK PubMed Central (United Kingdom)

We proposed a faster pedigree-based generalized multifactor dimensionality reduction algorithm, called PedG-MDR II (PII), to detect gene-gene interactions underlying complex traits. Inherited...Full Text Available

2011-01-01

227

A duplex real-time RT-PCR assay for the detection of California serogroup and Cache Valley viruses  

UK PubMed Central (United Kingdom)

A duplex TaqMan real-time RT-PCR assay was developed for the detection of California (CAL) serogroup viruses and Cache Valley virus (CVV), for use in human surveillance. The targets selected...Full Text Available

2009-10-01

228

5-Fluorodeoxyuridine as an alternative to the synthesis of mixed hybridization probes for the detection of specific gene sequences.  

UK PubMed Central (United Kingdom)

Synthetic complementary oligonucleotides are useful hybridization probes for the detection of mRNAs and genes encoding proteins for which only a partial amino acid sequence is known. Usually this involves...Full Text Available

1988-03-01

229

The Detection and Tracking of Stack Effluent with a Forward ...  

Science.gov (United States)

... Arsenal, Colorado, are presented. The effluent was emitted in the demilitarization process of GB nerve gas. Since the effluent ...

1975-06-01

230

STUDY OF BRUCELLA POLYSACCHARID ANTIGENES. II. ...  

Science.gov (United States)

... 1959). It was not possible for us, however, to detect any reaction of this type in the annials immunized with brucela. Considering ...

1965-04-26

231

Nondestructive Detection Techniques of Garter Springs from CANDU Reactors  

Energy Technology Data Exchange (ETDEWEB)

The design and material characteristics of garter spring were summarized and Nondestructive detection techniques of garter spring were also described. In particular, Eddy current testing of loose type garter spring was used in Wolsung unit 1 and was described in detail. The inspection technique of tight type garter spring has not been established and all candidated techniques were investigated in order to choose the possible detection technique. Candidated nondestructive techniques including RFEC, PEC, Magnetic technique using GMR sensor, AE, Guided Wave technique, and high frequency ultrasonic technique, are summarized for evaluating the detectability of tight garter spring.

2004-04-15

232

Individualized Stress Detection System - NASA  

Science.gov (United States)

Sep 16, 2010 ... Taking military operations as an example, there is evidence that stress-related behavioral disorders and mental conditions such as anxiety, ...

233

Half-lives of 35 radionuclides  

International Nuclear Information System (INIS)

... 67 gamma detection hafnium 180 half-life indium 111 iodine 125 iodine 131

235

Detection of mice lung cancer by neutron radiography  

Energy Technology Data Exchange (ETDEWEB)

Thermal neutron beam from the TNRF of JRR-3M was utilized for detection of mice lung cancer in vivo. Both the static and real-time neutron imaging were tried. Very strong thermal neutron beam is necessary to detect lung cancers because small changes are hidden by the very large attenuation of thermal neutron beam by the hydrogens in the tissues. The detection was successfully performed. Especially, the Super Eye of Hamamatsu Photonics contributed very effectively. Bone marrows and cartilages were also shown clearly. If an efficient and compact neutron source will become available in future, this method will grow up as a powerful tool for biomedical application. (author).

1995-11-01

238

Detection of Mitochondrial DNA Mutations in Mammary ...  

Science.gov (United States)

... Loss of Heterozygosity in Normal Breast Epithelial Tissue and Benign Breast Lesions in BRCA1/2 Carriers with Breast Cancer. ...

2004-09-01

239

Detection and Diagnosis of Oral Neoplasia with an Optical ...  

Science.gov (United States)

... Thus, 0CM provides the potential to image epithelial tissue with the subcellular resolution needed to assess the pathologic state of tissue. ...

240

Advanced phosphors  

Energy Technology Data Exchange (ETDEWEB)

This invention relates to new phosphor materials and to combinatorial methods of synthesizing and detecting the same. In addition, methods of using phosphors to generate luminescence are also disclosed.

2000-01-01

241

Supernova Neutrinos Detection On Earth  

CERN Document Server

In this paper, we first discuss the detection of supernova neutrino on Earth. Then we propose a possible method to acquire information about $\\theta_{13}$ smaller than $1.5^\\circ$ by detecting the ratio of the event numbers of different flavor supernova neutrinos. Such an sensitivity cannot yet be achieved by the Daya Bay reactor neutrino experiment.

2009-01-01

242

Neutronic detection device with extended flux range for control of nuclear reactors. Dispositif de detection neutronique a dynamique etendue pour le controle et la commande des reacteurs nucleaires  

Energy Technology Data Exchange (ETDEWEB)

The neutron detector is cased in a metal envelop and has one detector with a very sensitive fission chamber and a second detector with a fission chamber less sensitive that the first one and a boron coated ionisation chamber for reducing gamma radiation detection.

1992-06-12

243

Method for detecting and diagnosing disease caused by pathological protein aggregation  

Energy Technology Data Exchange (ETDEWEB)

A method is provided for detecting pathological macromolecules in a patient. The method is comprised of the following: obtaining body fluid from the patient; pretreating the body fluid; subjecting the pretreated body fluid to size-exclusion chromatography to create an excluded fluid; and analyzing the excluded fluid to detect macromolecules having a predetermined molecular weight. The method also allows for comparing elution spectra with reference spectra of suspect pathologic proteins.

2000-05-16

244

Indirect Dark Matter Detection with Cosmic Antimatter  

CERN Document Server

The indirect detection of particle dark matter (DM) is based on the search for anomalous components in cosmic rays (CRs) due to the annihilation of DM pairs in the galactic halo, on the top of the standard astrophysical production. These additional exotic components are potentially detectable at Earth as spectral distortions for the various cosmic radiations: $\\chi + \\chi \\to q \\bar{q}, W^+ W^-, ... \\to \\bar{p}, \\bar{D}, e^+ \\gamma and \

2010-01-01

245

Improving airport explosives detection  

Energy Technology Data Exchange (ETDEWEB)

ORNL has developed the technology to detect hidden explosives in luggage using X ray and neutron detection devices. The Federal Aviation Administration has ordered the airlines to buy and install Thermal Neutron Analysis (TNA) units. The combined pulsed-neutron and X-ray interrogation inspection (CPNX) system developed at ORNL uses less radioactive materials as well as being more sensitive to weapons, electronic devices and plastic explosives.

1990-01-01

246

Detection of Atopobium vaginae in postmenopausal women by cultivation-independent methods warrants further investigation.  

Science.gov (United States)

We sequenced 16S rRNA genes from the vaginal swab contents of a postmenopausal woman with asymptomatic bacterial vaginosis (BV). Sequences from Atopobium vaginae were the most commonly detected. In a survey of 35 other postmenopausal women, this organism was detected in 44% with BV but not in any subjects deemed healthy. PMID:15071062

2004-04-01

247

Assessing the Risks of Sampling Rates for Surveilling a Population  

British Library Electronic Table of Contents (United Kingdom)

Surveillance of a population, such as a weapon stockpile, is needed to discover manufacturing defects as well as deterioration as the population ages. This article considers the risks of sampling rates for surveillance from three perspectives: detection probability of defects in a proportion of a population with pass/fail data, detection of a trend in a defective proportion of the population with pass/fail data, and detection of a trend with quantitative degradation measurements. Understanding of these risks will help the decision maker choose a sampling rate to protect against such problems of a specified size at a tolerable risk.

2011-01-01

248

Why Gabor Frames? Two Fundamental Measures of Coherence and Their Role in Model Selection  

CERN Document Server

The problem of model selection arises in a number of contexts, such as subset selection in linear regression, estimation of structures in graphical models, and signal denoising. This paper generalizes the notion of "incoherence" in the existing literature on model selection and introduces two fundamental measures of coherence---termed as the worst-case coherence and the average coherence---among the columns of a design matrix. It utilizes these two measures of coherence to provide an in-depth analysis of two variants of a simple one-step thresholding (OST) algorithm for model selection and proves that OST is feasible for model selection as long as the design matrix obeys an easily verifiable property. One of the key insights offered by the ensuing analysis in this regard is that if the design matrix has reasonably small worst-case and average coherence then OST performs near-optimally when either (i) the energy of any nonzero entry of the signal is close to the ...

2010-01-01

249

User-friendly algorithms for estimating completeness and diversity in randomized protein-encoding libraries.  

Science.gov (United States)

Directed evolution of proteins depends on the production of molecular diversity by random mutagenesis. While a number of methods have been developed for introducing this diversity, the best ways to sample it are not always clear. Here we used simple statistics to analyse completeness and diversity in randomized libraries generated by oligonucleotide-directed mutagenesis, error-prone polymerase chain reaction (epPCR) and in vitro recombination of highly homologous sequences. For oligonucleotide-directed mutagenesis, we derive equations to estimate how complete a given library is expected to be and also to predict the size of library required to give a fixed probability of being 100% complete. We describe the statistical bases for computer programs which estimate the number of distinct variants represented in epPCR and shuffled libraries, dubbed PEDEL and DRIVeR, respectively. These programs allow the user to calculate (rather than guess) the diversity represented in ...

2003-06-01

250

Tribological initial processes on 100Cr6 roller bearing steel in fuel-lubricated point contact; Tribologische Initialprozesse auf 100Cr6-Waelzlagerstahl im kraftstoffgeschmierten Punktkontakt  

Energy Technology Data Exchange (ETDEWEB)

The authors investigated the development of tribochemical reaction layers and surface-level structural changes in a fuel-lubricated roller bearing steel 100Cr6 in the limiting friction range, using two different variants of surface treatment and heat treatment. Tribological experiments were carried out in a laboratory test stand with reversing sliding wear under varying loads and with a varying number of friction cycles. [German] Ziel der vorliegenden Arbeit war es, die Entstehung von tribochemischen Reaktionsschichten und oberflaechennahen Gefuegeaenderungen am Waelzlagerstahl 100Cr6 bei Kraftstoffschmierung im Grenzreibungsbereich fuer je zwei Oberflaechenbearbeitungen und Waermebehandlungen zu untersuchen. Dazu wurden tribologische Kurzversuche in einem Laborpruefstand mit reversierender Gleitbeanspruchung unter Variation der Last und der Anzahl der Reibzyklen durchgefuehrt. (orig.)

2000-08-01

251

Treatment and recycling of spent nuclear fuel. Actinide partitioning - Application to waste management  

International Nuclear Information System (INIS)

subsequent to its in-reactor dwell time, spent fuel still contains large amounts of materials that are recoverable, for value-added energy purposes (uranium, plutonium), together with fission products, and minor actinides, making up the residues from nuclear reactions. The treatment and recycling of spent nuclear fuel, as implemented in France, entail that such materials be chemically partitioned. The development of the process involved, and its deployment on an industrial scale stand as a high achievement of French science, and technology. Treatment and recycling allow both a satisfactory management of nuclear waste to be implemented, and substantial savings, in terms of fissile material. Bolstered of late as it has been, due to spectacularly skyrocketing uranium prices, this strategy is bound to become indispensable, with the advent of the next generation of fast reactors. This Monograph surveys the chemical process used for spent fuel treatment, and its ...

2008-01-01

252

Transition of coal industry of the USSR to full self-financing  

Energy Technology Data Exchange (ETDEWEB)

Describes progress made with the new economic system in the USSR coal industry since full self-financing was introduced on 1 January 1989, pointing out that mining is now being carried out at greater depths than before (515 m in 1988, 457 m in 1981 on the average) and that an increasing proportion of coal is being produced by mines liable to coal and gas bursts (62.3% in 1988, 59.6% in 1981). More difficult conditions means that mining costs are increasing. Explains system of agreements between teams of workers and mine management regarding output and extraction costs. Reveals that on 1 January 1990 a new list of coal prices will include 90% price rises on average, as a result of need for mines to finance themselves. There are to be 2 variants of this price list: one containing standard nationwide prices, the other based on mining areas, taking into account different geological and other conditions. Concludes by emphasizing the need to improve productivity, by ...

1989-11-01

253

Thermodynamic properties of dicarbonyl rhodium o-semiquinonate complex whose crystals display photomechanical properties  

Energy Technology Data Exchange (ETDEWEB)

In an adiabatic low-pressure calorimeter, the temperature dependence of the standard molar heat capacity of paramagnetic dicarbonyl rhodium complex with o-semiquinone (CO){sub 2}Rh(SQ) has been determined in the range from T=(6 to 355)K mainly with an accuracy of about 0.3%. Over the ranges from T=(205 to 234) K, T=(266 to 315)K and T=(316 to 345)K physical transformations have been revealed and their enthalpies and entropies have been estimated. The experimental data were used to calculate the thermodynamic functions C{sub p,m}{sup o}/R,{delta}{sub 0}{sup T}H{sub m}{sup o}/(R.K),{delta}{sub 0}{sup T}S{sub m}{sup o}/R and {phi}{sub m}{sup o}={delta}{sub 0}{sup T}S{sub m}{sup o}-{delta}{sub 0}{sup T}H{sub m}{sup o}/T (where R is the universal gas constant) between T=(0 and 355)K. The fractal dimension D in the heat capacity function of the fractal variant of Debye heat capacity theory has been evaluated.

2006-06-15

254

The role of crystallographic and geometrical relationships between #alpha# and #beta# phases in an #alpha#/#beta# titanium alloy  

International Nuclear Information System (INIS)

The present study has examined for #alpha#/#beta#-Ti alloys the relationship between the morphology and crystallography of Widmanstaetten plates of #alpha#-Ti in colonies within a prior grain of #beta#-Ti. Thus, optical metallography, scanning electron microscopy and transmission electron microscopy have been used to characterize the morphological features of the microstructure, whereas orientation-imaging microscopy (OM) and transmission electron microscopy (TEM) have been employed to reveal crystallographic information. It has been discovered that within a prior #beta#-Ti grain, although the growth direction of the Widmanstaetten plates in given colonies may differ by large angles from #alpha#-plates in other colonies, they may exhibit very close crystallographic relationships. For example, inclined #alpha#-plates may share common basal planes and be related by a rotation of #approx#10.5 deg. about the c-axis of the crystals. This phenomenon has been interpreted on the basis of ...

2003-09-15

255

The development of the high-temperature reactor. In memoriam Prof. Dr. rer.nat. Dr.-Ing. e.h. Rudolf Schulten  

International Nuclear Information System (INIS)

In the future even more than in the past, nuclear power will be indispensable in the present industrialized countries and in those still under development. The safe, nonpolluting, and economic supply of energy to mankind in the future includes so many different problems that the technology of the high-temperature reactor at its present level of development, and with the possibilities is offers above and beyond those provided by other, established, technologies, does not have to mark the end of some old line of development, but rather should be seen as the starting point of a development offering promise for the future. It is for this very reason that the extensive, valuable knowledge and experience accumulated in the construction, operation, and decommissioning of the AVR and THTR plants, the development of the HTR module and other variants and, last, but not least, the valuable results of projects such as PNP, NFE, and HHT, must be preserved at the research ...

256

The Waste Management Plan integration into Decommissioning Plan of the WWR-S research reactor from Romania  

International Nuclear Information System (INIS)

The paper presents the progress of the Radioactive Waste Management Plan which accompanies the Decommissioning Plan for research reactor WWR-S located in Magurele, Ilfov, near Bucharest, Romania. The new variant of the Decommissioning Plan was elaborated taking into account the IAEA recommendation concerning radioactive waste management. A new feasibility study for WWR-S decommissioning was also developed. The preferred safe management strategy for radioactive wastes produced by reactor decommissioning is outlined. The strategy must account for reactor decommissioning, as well as rehabilitation of the existing Radioactive Waste Treatment Plant and the upgrade of the Radioactive Waste Disposal Facility at Baita-Bihor. Furthermore, the final rehabilitation of the laboratories and reusing of cleaned reactor building is envisaged. An inventory of each type of radioactive waste is presented. The proposed waste management strategy is selected in accordance with the IAEA ...

2008-05-28

257

TMPRSS6 rs855791 modulates hepcidin transcription in vitro and serum hepcidin levels in normal individuals.  

Science.gov (United States)

The iron hormone hepcidin is inhibited by matriptase-2, a liver serine-protease encoded by TMPRSS6 gene. Cleaving the BMP-coreceptor hemojuvelin, matriptase-2 impairs the BMP/SMAD signaling pathway, downregulates hepcidin and facilitates iron absorption. TMPRSS6 inactivation causes iron-deficiency-anemia refractory to iron administration both in humans and mice. Genome wide association studies have shown that the SNP rs855791, which causes the matriptase-2 V736A amino acid substitution, is associated with variations of serum iron, transferrin saturation, hemoglobin and erythrocyte traits. Here we show that in vitro matriptase-2 736(A) inhibits hepcidin more efficiently than 736(V). Moreover, in a genotyped population, after exclusion of samples with iron deficiency and inflammation, hepcidin, hepcidin/transferrin saturation and hepcidin/ferritin ratios were significantly lower and iron parameters were consistently higher in homozygotes 736(A) than in 736(V). Our results indicate that ...

2011-08-26

258

Synthesis of alkylated deoxyno irimycin and 1,5-dideoxy-1,5-iminoxylitol analogues: : Polar side-chain modification, sulfonium and selenonium heteroatom variants, conformational analysis, and evaluation as glycosidase inhibitors  

DEFF Research Database (Denmark)

The syntheses of N-alkylated deoxynojirimycin and 1,5-dideoxy-1,5-iminoxylitol derivatives having either a D- or an L-erythritol-3-sulfate functionalized N-substituent are reported. The alkylating agent used was a cyclic sulfate derivative, whereby selective attack of the nitrogen atom at the least hindered primary center afforded the desired ammonium salt. In aqueous solution, these salts were configurationally labile at the ammonium center. Sulfonium and/or selenonium analogues of the ammonium salts were prepared by analogous reactions. The chalcogen salts were obtained as mixtures of diastereomers, separable in some cases, differing only in the stereochemistry at the configurationally stable sulfur or selenium atoms. Proof of configuration and conformation of each compound was obtained by detailed NMR experiments. The compounds are six-membered ring analogues of salacinol, a known sulfonium-salt glucosidase inhibitor. Evaluation of the target compounds for enzyme inhibition of the ...

2004-01-01

259

Some medical applications of thermomechanically treated titanium nickelide  

Energy Technology Data Exchange (ETDEWEB)

An original device and a method of its application for restoring of the function of relatively incompetent valves (both patented) are elaborated. Application of the new device allows to lower the difficulty of surgical treatment, to decrease the duration of operation and post-operative period. The long-term results of six-year long experience of its application are presented. The patients examination after 2,5-3,0-year post-operation period shows perfect vein valve correction. A device for stone extraction from tubular organs (patented) fabricated with titanium nickelide superelastic alloy is presented. The new suggested design is free of the drawback inherent in the previous one. The working element of the device is formed as a truncated cone or a truncated cone coaxial with the cylinder (the previous design was formed as a full cone) that prevents overstraining and residual strain accumulation during the manipulation process. Since the first publication the design of spiral stent and ...

2001-11-01

260

Resolving the Pu Electronic Structure Enigma: Past Lessons and Future Directions  

Energy Technology Data Exchange (ETDEWEB)

The nature of the 5f electronic structure of plutonium (Pu) remains unclear. [1] Despite many recent attempts to resolve the issue, a plethora of important unanswered questions remain. While many theoretical approaches to the problem have been promulgated, the real source of the difficulty is the absence of sufficient experimental benchmarking. This paucity of impact on the part of experimental results is driven in part by the difficulties of working with Pu: it is highly radioactive, biologically toxic, chemically reactive and restricted in its distribution and permitted access to user facilities. The results of these liabilities include the following: (1) it is very difficult, if not impossible, to get large single crystals of single phase samples and; (2) many state of the art experiments can not be done because general user facilities are not available for use with Pu samples. Additionally, there is the apparently bizarre nature of Pu, which seems to defeat the efforts to analyze ...

2008-05-30

261

Online monitoring of power transformers - a new low-cost system for small and medium power transformers; Monitoring von Leistungstransformatoren - Jetzt auch fuer kleine und mittlere Baugroessen  

Energy Technology Data Exchange (ETDEWEB)

Until now, monitoring of power transformers focussed mainly large generator and network transformers. Siemens goes a step ahead and provides a system especially developed and designed for small and medium power transformers, e.g. for the 100 kV level. This low cost version could be achieved by restriction to really necessary measuring quantities. This allows to realize also for small and medium power transformers an online monitoring including an estimation of aging and as an option an early warning to avoid unexpected failures. (orig.) [German] Die Ueberwachung (Monitoring) von Leistungstransformatoren war bisher vor allem fuer Maschinentransformatoren und grosse Netzkuppeltransformatoren in der Diskussion. Siemens geht einen Schritt weiter und stellt nun auch ein System bereit, das speziell fuer kleine und mittlere Leistungstransformatoren, z.B. der 110-kV-Spannungsebene, konzipiert ist. Diese kostenguenstige Variante wurde durch Beschraenkung auf die aus ...

1999-09-20

262

Non local theories: New rules for old diagrams  

International Nuclear Information System (INIS)

We show that a general variant of the Wick theorems can be used to reduce the time ordered products in the Gell-Mann and Low formula for a certain class on non local quantum field theories, including the case where the interaction Lagrangian is defined in terms of twisted products. The only necessary modification is the replacement of the Stueckelberg-Feynman propagator by the general propagator (the 'contractor' of Denk and Schweda) D(y-y';#tau#-#tau#')=(1)/i(#DELTA#_+(y-y')#theta#(#tau#-#tau#')+#DELTA#+(y'-y)#theta#(#tau#'-#tau#)), where the violations of locality and causality are represented by the dependence of #tau#,#tau#' on other points, besides those involved in the contraction. This leads naturally to a diagrammatic expansion of the Gell-Mann and Low formula, in terms of the same diagrams as in the local case, the only necessary modification concerning the Feynman rules. The ordinary local theory is easily recovered as a special case, and there is a ...

2004-08-01

263

Neutron irradiation of superconducting compounds  

International Nuclear Information System (INIS)

The effects of neutron irradiation on the superconducting and normal state properties of alloys and compounds are presented. Particular emphasis is placed on the A-15 compounds where the effects of neutron irradiation on Tsub(c), Hsub(c_2), long range order parameter and lattice parameter are described. Large depressions (up to 80%) in Tsub(c) are observed for all the A-15 compounds studied with the exception of Mo_3Os where much smaller decreases in Tsub(c) are seen. Along with the decrease in Tsub(c) and increase in lattice parameter, the degree of long range order, as measured by X-ray and neutron diffraction, decreases. Also presented are the results of isothermal and isochronal anneals up to 900"0C. The unirradiated value of Tsub(c) can be restored by annealing, and for those systems where measurements have been made, recovery of the lattice parameter and order parameter also takes place. The effects observed in irradiated material, together with those observed in unirradiated but ...

264

Monte-Carlo-based simulation of LWR cores with innovative fuel concepts  

International Nuclear Information System (INIS)

High resolution Monte-Carlo simulations show that the neutron spectrum, fuel burnup and fuel temperature feedback effect of a PWR core loaded with Thoria-based fuel (Th/Pu-O_2) do not significantly differ from the MOX fuelled one due to the similar neutronic characteristics of both fertile materials (Th-232, U-238). The core physics of this fuel variant is characterized by an enhanced moderator/void temperature coefficient (by factor 2.4) and high incineration rate for Pu (approx. 60 %). A PWR core loaded with the Molybdenum-based inert matrix fuel (IMF) - in contrast to MOX-, shows a harder spectrum, resulting in small temperature coefficients of reactivity and particularly in a higher fuel depletion rate as well as an enhanced TRU reduction performance. The incineration of Pu amounts to 46 % resulting, in turn, in generation of minor actinides of about 10 % of the total Pu consumption. The higher excess reactivity resulting from the initial Pu contents is ...

2009-05-03

265

Light-dependent regulation of DEL1 is determined by the antagonistic action of E2Fb and E2Fc.  

Science.gov (United States)

Endoreduplication represents a cell cycle variant during which multiple rounds of DNA replication occur without subsequent chromosome separation and cytokinesis, resulting into a cellular increase of the DNA content. Although the DNA ploidy level of cells is controlled by external stimuli such as light, currently limited knowledge is available on how environmental signals regulate the endoreduplication cycle at the molecular level. Previously, we have demonstrated that the conversion from the mitotic cell cycle into an endoreduplication cycle is mediated by the atypical E2F transcription factor DEL1 that operates as a repressor of endocycle onset. Here, we identified DEL1 as a transcriptional target of the classical E2Fb and E2Fc transcription factors that antagonistically control DEL1 transcript levels through competition for a single E2F cis-acting binding site. Correspondingly with the reported opposite effect of light on the E2Fb and E2Fc protein levels, the ...

2011-09-01

266

Input of cogeneration units in the future Dutch electric power supply. Inzet van warmte/krachteenheden in de toekomstige Nederlandse elektriciteitsvoorziening  

Energy Technology Data Exchange (ETDEWEB)

An investigation was carried out to determine the significance of a large input of cogeneration units for the electric power generation, next to the input of coal and uranium. Thereto a production plant has been set up to generate heat and electric power. The plant serves as a basis for a number of comparative calculations: basic calculations to investigate the influence of some strategies on the cogeneration input, and sensitivity calculations to determine the influence of a few changes in the starting points. Some variants have been deduced from this plant, which is based on prognosis for the year 2000. By means of the computer calculation program OPINIE (Optimale Inzet en Instelling van Eenheden: Optimal Input and Installation of Units) the minimal variable costs were calculated for different situations. Finally for each considered situation the total annual costs have been calculated. 53 figs., 13 refs., 30 tabs., 3 apps.

1987-02-01

267

Impact of genetic polymorphisms in ABCB1, CYP2B6, OPRM1, ANKK1 and DRD2 genes on methadone therapy in Han Chinese patients  

British Library Electronic Table of Contents (United Kingdom)

Aims: The present study explored the integrative effect of genes encoding methadone pharmacokinetic and pharmacodynamic pathways on methadone maintenance doses in Han Chinese Patients. Materials & methods: Genomic DNA was extracted from 321 opioid-dependent patients and 202 healthy controls, and realtime-PCR and PCR-RFLP were conducted to determine the genotypes. Results: Pair-wise comparisons revealed that carriers of the variants ABCB1 3435C>T or CYP2B6 516G>T alleles were more likely to require a higher methadone dose than noncarriers (both p G or 939C>T allele had a two-fold chance of requiring a lower methadone dose than noncarriers (p = 0.001). Proportional odds regression with adjustment of cofactors demonstrated that ...

2011-01-01

268

Hemoglobin of mice with radiation-induced mutations at the hemoglobin loci  

International Nuclear Information System (INIS)

Chemical analyses were done on the abnormal hemoglobins of the five (101 x SEC)F_1 offspring of X- irradiated adult SEC mice to determine which hemoglobin genes were expressed in each hemoglobin variant. Three offspring of irradiated SEC males did not express either of the two kinds of #alpha#-chains normally found in all SEC mice. The deficient #alpha#-chain synthesis caused these mice to exhibit an #alpha#-thalassemia similar to human #alpha#-thalassemia. Scanning electron microscopy was used to show that many erythrocytes of mice with #alpha#-thalassemia have bizarre shapes; e.g. many erythrocytes appeared flattened or had thorny projections (acanthocytes). One mutant with a tandem duplication of a segment of chromosome 7 (site of locus determining #beta#-chain structure) produced twice as much SEC as 101 #beta#-chain polypeptides. One mutant that probably arose by non-disjunction of chromosome 7's in its unirradiated 101 mother and loss of chromosome 7 from the ...

269

Global and trajectory attractors for a nonlocal Cahn-Hilliard-Navier-Stokes system  

CERN Document Server

The Cahn-Hilliard-Navier-Stokes system is based on a well-known diffuse interface model and describes the evolution of an incompressible isothermal mixture of binary fluids. A nonlocal variant consists of the Navier-Stokes equations suitably coupled with a nonlocal Cahn-Hilliard equation. The authors, jointly with P. Colli, have already proven the existence of a global weak solution to a nonlocal Cahn-Hilliard-Navier-Stokes system subject to no-slip and no-flux boundary conditions. Uniqueness is still an open issue even in dimension two. However, in this case, the energy identity holds. This property is exploited here to define, following J.M. Ball's approach, a generalized semiflow which has a global attractor. Through a similar argument, we can also show the existence of a (connected) global attractor for the convective nonlocal Cahn-Hilliard equation with a given velocity field, even in dimension three. Finally, we demonstrate that any weak solution fulfilling ...

2011-01-01

270

Focal lesions in external auditory canal: computed tomography images  

International Nuclear Information System (INIS)

To analyze and review the most common focal lesions of the external auditory canal (EAC), describing the computed tomography (CT) findings. The CT images of EAC were reviewed in a series of 167 patients. Abnormal findings were recorded in 13 cases. The CT images were correlated with otoscopic and/or intraoperative findings. There were four cases of osteoma (one located outside the EAC); all of which were treated surgically, as was the one case of exostosis. Six patients presented debris in EAC, coinciding with clinical evidence of external otitis. There were two cholesteatomas derived from EAC, one of them secondary to survery to treat osteoma. On patient was diagnosed as having a basal cell carcinoma of the ear, extending to EAC, but refused to undergo surgery. Five patients presented small triangular laminae of dense bone arising from the upper wall of the EAC which were defined as abnormal variants of the fusion of the temporal squamous epithelium to the ...

271

Effect of low copper content and heat treatment on intergranular corrosion of model AlMgSi alloys  

International Nuclear Information System (INIS)

Certain 6000-series extrusions may develop susceptibility to intergranular corrosion (IGC) by improper heat treatment, especially if copper is present as an alloying element. Although occurrence of IGC in such cases is documented, the underlying mechanisms are not adequately explained. We present corrosion data for two model alloys, having different Cu content and Mg:Si ratio, showing that the susceptibility to IGC depended primarily on the Cu content and secondly on thermal processing. Low Cu samples (0.0005 wt.% Cu) were essentially resistant to IGC. High Cu samples (0.12 wt.% Cu), which were air cooled after extrusion, exhibited significant IGC. However, IGC susceptibility was reduced significantly as a result of artificial aging to peak strength. Water quenched high Cu samples were essentially resistant to IGC. However, slight IGC susceptibility was introduced after aging. Electron optical characterisation revealed Al_4Mg_8Si_7Cu_2 (Q-phase) grain boundary precipitates on all the ...

2006-01-01

272

Dynamic User-Defined Similarity Searching in Semi-Structured Text Retrieval  

CERN Document Server

Modern text retrieval systems often provide a similarity search utility, that allows the user to find efficiently a fixed number k of documents in the data set that are most similar to a given query (here a query is either a simple sequence of keywords or the identifier of a full document found in previous searches that is considered of interest). We consider the case of a textual database made of semi-structured documents. Each field, in turns, is modelled with a specific vector space. The problem is more complex when we also allow each such vector space to have an associated user-defined dynamic weight that influences its contribution to the overall dynamic aggregated and weighted similarity. This dynamic problem has been tackled in a recent paper by Singitham et al. in in VLDB 2004. Their proposed solution, which we take as baseline, is a variant of the cluster-pruning technique that has the potential for scaling to very large corpora of documents, and is far ...

2007-01-01

273

Creep-rupture, creep strength and tensile data on Alloy 800 between 500-800"0C  

International Nuclear Information System (INIS)

The authors present tensile data and creep-rupture data out to approximately 40,000 h duration on low-carbon Alloy 800. Each of the four casts was heat treated to three conditions in tube form. When the test programme was originally conceived, the prime object was to obtain 100,000 hour design data; the programme was designed prior to some of the more recently discovered effects such as that of #gamma#' on ductility. Therefore no specific attempt was made to control to a low level, the Al and Ti contents of the casts. A subsequent programme was embarked upon in 1976 where these factors were taken into account. The bulk data obtained show many characteristics which are probably typical of the low-carbon variant of this material and both the quantity and duration of the data are a contribution to the knowledge of the long-term behaviour of this class of alloy, whose future use lies, inter alia, in nuclear applications over the temperature range for which ERA data ...

274

Common colorectal cancer risk variants in SMAD7 are associated with survival among prediagnostic nonsteroidal anti-inflammatory drug users: A population-based study of postmenopausal women  

British Library Electronic Table of Contents (United Kingdom)

Abstract Common single nucleotide polymorphisms (SNPs) in SMAD7 (18q21) have been linked to colorectal cancer (CRC) risk in genome-wide association studies, but little is known about their effects on survival. SMAD7 regulates gastrointestinal inflammation by inhibiting transforming growth factor- (TGFB), which can act as both a tumor suppressor and a promoter of metastasis. Regular use of cyclooxygenase-2 (COX2) inhibitors, such as nonsteroidal anti-inflammatory drugs (NSAIDs), reduces the risk of developing CRC. Because COX2 overexpression reduces the growth suppressing effects of TGFB, we hypothesized that survival may depend on both SMAD7 genotype and prediagnostic NSAID use. Postmenopausal women, ages 50-74, diagnosed with incident invasive CRC from 1997 to 2002 were identified using t...

2011-01-01

275

An adaptive filter to approximate the Bayesian strategy for sonographic beamforming.  

Science.gov (United States)

A first-principles task-based approach to the design of medical ultrasonic imaging systems for breast lesion discrimination is described. This study explores a new approximation to the ideal Bayesian observer strategy that allows for object heterogeneity. The new method, called iterative Wiener filtering, is implemented using echo data simulations and a phantom study. We studied five lesion features closely associated with visual discrimination for clinical diagnosis. A series of human observer measurements for the same image data allowed us to quantitatively compare alternative beamforming strategies through measurements of visual discrimination efficiency. Employing the Smith-Wagner model observer, we were able to breakdown efficiency estimates and identify the processing stage at which performance losses occur. The methods were implemented using a commercial scanner and a cyst phantom to explore development of spatial filters for systems with shift-variant ...

2010-07-19

276

Amyloidosis  

International Nuclear Information System (INIS)

The subjects covered in this Symposium range through almost every clinical medical specialty. From an average of one paper in each of the past three Symposiums, the explosive interest in cerebral amyloidosis has led to the presentation of 12 papers on this subject in the present volume. The genetically predisposed familial amyloidotic processes, such as the polyneuropathies and familial Mediterranean fever have also stimulated extensive and intriguing investigations which have revealed the striking effect of a single amino acid substitution in transforming a normal protein into a lethal ''amyloidogenic'' one. This Symposium clearly depicts the advances since the first amyloid fibril protein was definitively identified and defined 14 years ago. Since all amyloid fibril proteins so far described are variants of normal proteins, attention to gene abnormalities now becomes a significant focus as well as the pathogenic sequences which lead in these cases to twisted ...

1984-11-09

277

Speckle Reduction for LIDAR Using Optical Phase Conjugation  

Energy Technology Data Exchange (ETDEWEB)

Remote detection of chemicals using LIDAR (Light Detection and Ranging) utilizing DIAL (Differential Absorption LIDAR) is now a standard detection technique for both military and civilian activities. We have developed a novel nonlinear optical phase conjugation system that can reduce the effects of speckle noise and atmospheric turbulence on DIAL remote detection systems. We have shown numerically and experimentally that it is possible to increase the signal-to-noise (S/N) ratio for LIDAR systems under certain conditions using optical phase conjugation. This increase in S/N can result in more accurate detection of chemical effluents while simultaneously reducing the time necessary to acquire this information.

2001-02-26

278

No detectable XMRV in subjects with chronic fatigue syndrome from Quebec  

British Library Electronic Table of Contents (United Kingdom)

We investigated the presence of XMRV in a cohort of Quebec patients with chronic fatigue syndrome (CFS). DNA was purified from activated peripheral blood mononuclear cells (PBMCs) and PCR was used to detect XMRV gag and env in 72 patients. Anti-XMRV antibodies were searched in sera of 62 patients by Western blot analysis. Attempts to detect XMRV antigens was made, using immunofluorescence with Gag anti-p30 antiserum on activated PBMC from 50 patients. Plasma viremia was measured by RT-PCR on 9 subjects. Finally, detection of infectious virus in 113 CFS subjects was made by co-culture of PHA+IL-2 activated PBMC with human LNCaP carcinoma cells, and by infecting the same susceptible cells with plasma, using a reverse transcriptase (RT) assay as a readout in both experiments. No detection of ...

2011-01-01

279

Multistage audiovisual integration of speech: dissociating identification and detection  

British Library Electronic Table of Contents (United Kingdom)

Speech perception integrates auditory and visual information. This is evidenced by the McGurk illusion where seeing the talking face influences the auditory phonetic percept and by the audiovisual detection advantage where seeing the talking face influences the detectability of the acoustic speech signal. Here, we show that identification of phonetic content and detection can be dissociated as speech-specific and non-specific audiovisual integration effects. To this end, we employed synthetically modified stimuli, sine wave speech (SWS), which is an impoverished speech signal that only observers informed of its speech-like nature recognize as speech. While the McGurk illusion only occurred for informed observers, the audiovisual detection advantage occurred for na?ve observers as well. Thi...

2011-01-01

280

Method and device for identifying different species of honeybees  

Energy Technology Data Exchange (ETDEWEB)

A method and device have been provided for distinguishing Africanized honeybees from European honeybees. The method is based on the discovery of a distinct difference in the acoustical signatures of these two species of honeybees in flight. The European honeybee signature has a fundamental power peak in the 210 to 240 Hz range while the Africanized honeybee signature has a fundamental power peak in the 260 to 290 Hz range. The acoustic signal produced by honeybees is analyzed by means of a detecting device to quickly determine the honeybee species through the detection of the presence of frequencies in one of these distinct ranges. The device includes a microphone for acoustical signal detection which feeds the detected signal into a frequency analyzer which is designed to detect the presence of either of the known fundamental wingbeat frequencies unique to the acoustical signatures ...

1989-01-01

281

Giant magnetoresistance sensing technologies for detecting small defects in metallic structures  

Science.gov (United States)

Giant magnetoresistance (GMR) has been used with Eddy current testing to detect small defects not only in thin film structures but also in multilayered metallic structures. This work detected small scratches in the thin film under the surface where these defects were unable to be inspected or monitored by regular testing. In addition, rotational GMR magnetic sensor based Eddy current probes were used for detecting buried corner cracks at the edge of holes in metallic structures. The results of this study proved that giant magnetoresistance is very powerful and effective to sense the magnetic field, which is the result from the perturbation of the Eddy currents caused by a defect. This method can be used for quality control of metallization layers on silicon wafer and to detect cracks in thick structures such as cracks in aging aircraft.

2008-01-01

282

Fuel injection control for diesel engine  

Energy Technology Data Exchange (ETDEWEB)

A method is described for controlling fuel injection in a diesel engine having a fuel injection nozzle, comprising the steps of: detecting an idling state of the diesel engine and pressure in a combustion chamber; obtaining a pressure increment rate from the pressure detected by the detecting step; selecting a valve opening pressure of the fuel injection nozzle at a relatively low level when the idling state is detected by the detecting step, thereby setting a two peaks characteristics of a fuel injection rate; and controlling the fuel injection nozzle in response to the pressure increment rate so that the pressure increment rate in the combustion chamber is maintained within a predetermined value by changing a fuel injection quantity of a pilot injection from the fuel injection nozzle.

1987-11-10

283

Detection of intracardiac calcification using Fuji computed radiography  

International Nuclear Information System (INIS)

Fuji Computed Radiography (FCR) was evaluated for detection of intracardiac calcification as compared with conventional radiography in 77 patients. Intracardiac calcification was found in 37 patients (left coronary artery: 31, right coronary artery: 11, valve: 9) on cine-fluorography. The sensitivity for detecting these calcified foci with FCR was higher than conventional screen-film method. Especially, sensitivity for detecting left coronary artery calcification with FCR was significantly higher than conventional method (71 %, 32 %) (p < 0.01), Fine anatomical details of calcification were well shown on FCR. Chest radiography using FCR is of great use for detection of intracardiac calcification. (author).

1986-01-01

284

Using n-ZnO-Al as window layer in pilot production of CIGSSe solar modules: Status and trends. Status of CIGSSe pilot scale production at Munich; Einsatz von n-ZnO:Al als Fensterschicht in der Pilotfertigung von CIGSSe-Solarmodulen: Status and Entwicklung. Status der CIGSSe-Pilotfertigung in Muenchen  

Energy Technology Data Exchange (ETDEWEB)

Shell Solar GmbH is working on a variant of the so-called stacked elemental layer process for CIGSSe absorber production. The metal films resp. the selenium are deposited on the Mb electrode at room temperature by DC sputtering (CIG) or evaporation (Se) and then processed into semiconductors by rapid thermal annealing (RTP). Currently, the mean efficiency of the pilot plant is i 12.6 {+-} 0.2 % for non-sealed 30 x 30 cm{sup 2} modules, the key efficiency is 13.0 %. In addition to the 30 x 30 cm{sup 2} pilot line, a small series of 60x90cm2 modules was constructed in December 2004. Here, the mean efficiency was 13.0 percent while the average module power was higher than 60 W. The contribution also describes investigations of ceramically sputtered n-ZnO:Al layers with reduced Al concedntrations of 1 percent and on reactively sputtered n-ZnO.Al layers from the double roller magnetron. (orig.) [German] Bei Shell Solar GmbH wird eine Variante des ...

2005-07-01

285

Fault detection and fault diagnosis system for engine; Engine no kosho yochi shindan system  

Energy Technology Data Exchange (ETDEWEB)

The fault detection and diagnosis system for gas engines was developed to improve the reliability of cogeneration systems (CGS). Most of existing fault detection systems monitor the trend of each part condition of engines and diagnose faults based on trend change, resulting in slow detection. Although early detection systems are available, those are complex, expensive and poor in flexibility and applicability. Since CGSs combined with gas engines increased to 1/3 of the whole CGS, engine troubles cause possible serious faults. The fault diagnosis system was thus developed to prevent serious faults which can early detect, in particular, abnormal conditions of parts around a combustion chamber such as ignition plug, intake valve and exhaust valve by monitoring exhaust pressure waveforms in an exhaust collector. Since this system can detect progressive occurrence ...

1996-03-29

286

Configurable Middleware-Level Intrusion Detection for Embedded Systems  

Energy Technology Data Exchange (ETDEWEB)

Embedded systems have become integral parts of a diverse range of systems from automobiles to critical infrastructure applications such as gas and electric power distribution. Unfortunately, research on computer security in general and intrusion detection in particular, has not kept pace. Furthermore, embedded systems, by their very nature, are application specific and therefore frameworks for developing application-specific intrusion detection systems for distributed embedded systems must be researched, designed, and implemented. In this paper, we present a configurable middleware-based intrusion detection framework. In particular, this paper presents a system model and a concrete implementation of a highly configurable intrusion detection framework that is integrated into MicroQoSCORBA, a highly configurable middleware framework developed for embedded systems. By exploiting the application-specific ...

2005-06-20

287

Hierarchical Kohonenen net for anomaly detection in network security.  

Science.gov (United States)

A novel multilevel hierarchical Kohonen Net (K-Map) for an intrusion detection system is presented. Each level of the hierarchical map is modeled as a simple winner-take-all K-Map. One significant advantage of this multilevel hierarchical K-Map is its computational efficiency. Unlike other statistical anomaly detection methods such as nearest neighbor approach, K-means clustering or probabilistic analysis that employ distance computation in the feature space to identify the outliers, our approach does not involve costly point-to-point computation in organizing the data into clusters. Another advantage is the reduced network size. We use the classification capability of the K-Map on selected dimensions of data set in detecting anomalies. Randomly selected subsets that contain both attacks and normal records from the KDD Cup 1999 benchmark data are used to train the hierarchical net. We use a confidence measure to label the ...

2005-04-01

288

Fatigue crack detection in aircraft skin structures using eddy current array technique  

International Nuclear Information System (INIS)

Detection of fatigue damage cracks in aircraft skin structures is an ongoing NDT challenge. Cracks growing rate is difficult to predict, and for this reason, it is important to detect them as soon as possible to avoid a catastrophic break. Eddy current methods are known and well-accepted techniques which are relatively simple to carry out. However, with conventional inspection of airframe structures using standard driver-pickup eddy current probes, it is difficult to detect small fatigue cracks initiated in the second layer of the skin and in the shadow region at fastener holes. Such difficulty is related to fasteners length and their spacing which reduces test sensitivity. This report explains the development of improved eddy current probe/technique to detect and visualize fatigue cracks in fasteners. In this study, an eddy current array probe was evaluated and new coil design was suggested. Several ...

2004-01-01

289

Clinical evaluation of life size image of Fuji computed radiography for detection of diffuse interstitial lung diseases  

Energy Technology Data Exchange (ETDEWEB)

To evaluate the diagnostic accuracy of Fuji computed radiography (FCR) in the detection of interstitial pulmonary infiltrates, FCR life-size images at a pixel size of 0.1 mm were compared with conventional radiographs taken on the same day. Seventeen radiologists assessed the radiographs and FCR images of 56 cases, including 39 cases of various interstitial lung diseases such as interstitial pneumonia, pulmonary abnormalities associated with collagen disease, sarcoidosis, multiple pulmonary metastases, diffuse panbronchiolitis and pulmonary emphysema, and 17 normal controls. All of the pulmonary abnormalities were confirmed by high resolution CT. Observer performance tests were carried out using receiver operating characteristic analysis. In 21 cases of increased pulmonary density revealed by high resolution CT, FCR was significantly superior to conventional radiographs in the detection of reticular or linear shadows. In 11 cases of subtle ...

1991-11-01

290

Clinical evaluation of life size image of Fuji computed radiography for detection of diffuse interstitial lung diseases  

International Nuclear Information System (INIS)

To evaluate the diagnostic accuracy of Fuji computed radiography (FCR) in the detection of interstitial pulmonary infiltrates, FCR life-size images at a pixel size of 0.1 mm were compared with conventional radiographs taken on the same day. Seventeen radiologists assessed the radiographs and FCR images of 56 cases, including 39 cases of various interstitial lung diseases such as interstitial pneumonia, pulmonary abnormalities associated with collagen disease, sarcoidosis, multiple pulmonary metastases, diffuse panbronchiolitis and pulmonary emphysema, and 17 normal controls. All of the pulmonary abnormalities were confirmed by high resolution CT. Observer performance tests were carried out using receiver operating characteristic analysis. In 21 cases of increased pulmonary density revealed by high resolution CT, FCR was significantly superior to conventional radiographs in the detection of reticular or linear shadows. In 11 cases of subtle ...

1991-01-01

291

New mass screening project for lung cancer with mobile spiral computed tomography (CT) and computed radiography (CR) in Ehime district  

Energy Technology Data Exchange (ETDEWEB)

To improve the detection rate of lung cancer, we have introduced low-dose CT and CR technique into a population-based annual mass screening. From December 1999, 3868 and 12618 individuals participated in this screening program with CT and with CR, respectively. Primary lung cancer was detected in 15 (0.39%) by CT and 8 (0.06%) by CR. This results show high detection rate of primary lung cancer as had been previously reported. (author)

2002-01-01

292

Microcantilever detector for explosives  

Energy Technology Data Exchange (ETDEWEB)

Methods and apparatus for detecting the presence of explosives by analyzing a vapor sample from the suspect vicinity utilize at least one microcantilever. Explosive gas molecules which have been adsorbed onto the microcantilever are subsequently heated to cause combustion. Heat, along with momentum transfer from combustion, causes bending and a transient resonance response of the microcantilever which may be detected by a laser diode which is focused on the microcantilever and a photodetector which detects deflection of the reflected laser beam caused by heat-induced deflection and resonance response of the microcantilever. 2 figs.

1999-06-29

293

Measurement of low-energy antiproton detection efficiency in BESS below 1 GeV  

Energy Technology Data Exchange (ETDEWEB)

An accelerator experiment was performed using a low-energy antiproton beam to measure antiproton detection efficiency of BESS, a balloon-borne spectrometer with a superconducting solenoid. Measured efficiencies showed good agreement with calculated ones derived from the BESS Monte Carlo simulation based on GEANT/GHEISHA. With detailed verification of the BESS simulation, the relative systematic error of detection efficiency derived from the BESS simulation has been determined to be {+-}5%, compared with the previous estimation of {+-}15% which was the dominant uncertainty for measurements of cosmic-ray antiproton flux.

2002-08-21

294

Low cost, low power, high sensitivity, real time neutron detection microsystem  

International Nuclear Information System (INIS)

A Si array neutron detector is proposed based on commercial CCD and CMOS sensor technology coupled with a thin film neutron conversion coating. System sensitivity is estimated for a baseline device containing a single array and various schemes to increase detection probability by simple area scaling and stacking are discussed. Some possible use scenarios are discussed involving static and moving sources. Likely neutron source fluxes for weapons grade and commercial grade nuclear material are estimated along with expected intensities of cosmic background neutrons which would establish a noise floor to detection limits.

2002-10-10

295

Interim explosives detection alternatives  

Energy Technology Data Exchange (ETDEWEB)

There is a general concern with insiders smuggling bomb quantities of explosives into sensitive facilities such as nuclear facilities. At this time, there is no single explosives detection device that is suitable for monitoring personnel and their packages for explosives in an operational facility environment. However, there are techniques combining available commercial technologies with procedures and threat analysis that can significantly increase the insiders risk and reduce the population of adversaries. This paper describes the available applicable explosives detection technologies and discusses the techniques that could be implemented on an interim basis. It is important that these techniques be considered, so that some interim level of security against the explosives threat can be established until more sophisticated equipment that is under development becomes available.

1991-01-01

296

Information detective quantum efficiency of X-ray film-intensifier foil systems  

Energy Technology Data Exchange (ETDEWEB)

The capability of screen-film combinations of detection and representation of information is described by the detective quantum efficiency (DQE). The DQE may be calculated from the sensitivity, the gradient of the characteristic curve, the modulation transfer function and the Wiener spectrum. These parameters have been determined for fourteen screen-film combinations and the DQE's have been calculated. It is shown that the low frequency region the DQE does not depend on spatial frequency. This constant level of DQE is mostly dependent on the absorbance of the screens. Consequences from this fact, as well for the manufacturer as for the user of the screens, are discussed.

1988-04-01

297

Information detective quantum efficiency of X-ray film-intensifier foil systems  

International Nuclear Information System (INIS)

The capability of screen-film combinations of detection and representation of information is described by the detective quantum efficiency (DQE). The DQE may be calculated from the sensitivity, the gradient of the characteristic curve, the modulation transfer function and the Wiener spectrum. These parameters have been determined for fourteen screen-film combinations and the DQE's have been calculated. It is shown that the low frequency region the DQE does not depend on spatial frequency. This constant level of DQE is mostly dependent on the absorbance of the screens. Consequences from this fact, as well for the manufacturer as for the user of the screens, are discussed. (orig.).

298

Detection of EDM defects under Monju support plate using experimental data from remote field eddy current probes and a multi-frequency algorithm  

International Nuclear Information System (INIS)

This paper describes detection of electro-discharged machine (EDM) defects in magnetic steam generator (SG) tubes of Monju fast breeder reactor (FBR). The EDM defects are located under support plate (SP), on the outer tube surface and they are detected by a remote field eddy current probe. Using the experimental measurements and a multi frequency algorithm, the defect signal can be extracted from the SP signal. The parameters of the multi-frequency algorithm were calculated by comparing SP measurements with two-dimensional finite element simulations (FEM). (author)

2006-07-01

299

Absolute calibration of the antiproton detection efficiency for BESS below 1 GeV  

Energy Technology Data Exchange (ETDEWEB)

An accelerator beam experiment was performed using a low-energy antiproton beam to measure antiproton detection efficiency of the BESS detector. Measured and calculated efficiencies derived from the BESS Monte Carlo simulation based on GRANT/GHEISHA showed good agreement. With detailed verification of the BESS simulation, the relative systematic error of detection efficiency derived from the BESS simulation has been determined to be {+-}5%, compared with the previous estimation of {+-}15% which was the dominant uncertainty for measurements of cosmic-ray antiproton flux. (author)

2001-12-01

300

A high-sensitivity scintillation chamber for radon in gas  

Energy Technology Data Exchange (ETDEWEB)

A large scintillation chamber of 6.7 l volume for direct radon concentration measurements in gas is presented. With two 5 in. photomultipliers on opposite sides, working in coincidence, a concentration as low as about 0.5 mBq/l is detectable with 10% standard deviation after 1000 min measuring time. With the achieved background count rate of 0.42 counts/min and the counting efficiency of 0.607 for [sup 222]Rn and its progenies the absolute minimal detectable specific activity is reached with 0.17 mBq/l at about 12 000 min. The method to determine this minimum detectable activity is outlined. ((orig.))

1994-06-15

301

x - NASA Technical Reports Server  

Science.gov (United States)

Mar 1, 2011 ... Radionuclide X-ray fluorescence analysis. 2: Detection of the X-ray fluorescence radiation excited by radionuclide radiation ...

302

x - NASA Technical Reports Server  

Science.gov (United States)

analysis of NaMBT in ethylene glycol-water solutions with high accuracy. It reduces analysis time, requires smaller samples, and is able to detect extremely ...

303

Untitled Document  

Science.gov (United States)

integrates multiple fisheries information systems to obtain a view of U.S. freshwater fish distribution. Information about NFDI National Framework for Early Detection, Rapid...

2011-06-23

304

Trinitrotoluene: assessment of occupational absorption during manufacture of explosives.  

UK PubMed Central (United Kingdom)

Trinitrotoluene (TNT) absorption was assessed in groups of workers at two explosives factories by measuring the urinary concentrations of dinitroaminotoluene (DNAT) metabolites. DNAT was detected in...Full Text Available

1986-07-01

305

The vomeronasal organ of the tammar wallaby  

UK PubMed Central (United Kingdom)

The vomeronasal organ is the primary olfactory organ that detects sexual pheromones in mammals. We investigated the anatomy of the vomeronasal organ of the tammar wallaby (Macropus eugenii),...Full Text Available

2008-08-01

306

Skin as an endocrine organ: implications for its function  

UK PubMed Central (United Kingdom)

Described as the body's largest organ, the skin is strategically located at the interface with the external environment where it has evolved to detect, integrate and respond to a diverse range...Full Text Available

2008-06-01

308

Seamless Integration of Detection and Therapy for Breast ...  

Science.gov (United States)

... that were previously adopted by Zhu [20], Skala [3] and Wang [5,7,8] et al. in their respective studies on epithelial tissue. ...

2007-06-01

309

Recommendations for the prevention of damage to steam turbines. 2. rev. ed.  

International Nuclear Information System (INIS)

The purpose of the recommendation is to prevent, to detect, and to remove soiling of guide and retrating blades of steam turbines, e.g. on account of foreign matter in steam dissolved. (TK/LN).

310

Proteinortho: Detection of (Co-)orthologs in large-scale analysis  

UK PubMed Central (United Kingdom)

BackgroundOrthology analysis is an important part of data analysis in many areas of bioinformatics such as comparative genomics and molecular phylogenetics. The ever-increasing flood...Full Text Available

311

Poisoning young minds.  

UK PubMed Central (United Kingdom)

For some neurotoxic chemicals, neurobehavioral effects are now considered to be among the most sensitive end points yet detected, particularly if exposures occur during critical windows of vulnerability....Full Text Available

1999-06-01

312

Pitch discrimination by ferrets for simple and complex sounds  

UK PubMed Central (United Kingdom)

Although many studies have examined the performance of animals in detecting a frequency change in a sequence of tones, few have measured animals' discrimination of the fundamental frequency...Full Text Available

2009-09-01

313

PET imaging of tumour hypoxia  

UK PubMed Central (United Kingdom)

Tumour hypoxia represents a significant challenge to the curability of human tumours leading to treatment resistance and enhanced tumour progression. Tumour hypoxia can be detected by non-invasive and...Full Text Available

314

Organization of optic lobes that support motion detection in a semiterrestrial crab  

UK PubMed Central (United Kingdom)

There is a mismatch between the documentation of the visually guided behaviors and visual physiology of decapods (Malacostraca, Crustacea) and knowledge about the neural architecture of their...Full Text Available

2005-12-19

315

Optimal dynamic detection of explosives  

Energy Technology Data Exchange (ETDEWEB)

The detection of explosives is a notoriously difficult problem, especially at stand-off distances, due to their (generally) low vapor pressure, environmental and matrix interferences, and packaging. We are exploring optimal dynamic detection to exploit the best capabilities of recent advances in laser technology and recent discoveries in optimal shaping of laser pulses for control of molecular processes to significantly enhance the standoff detection of explosives. The core of the ODD-Ex technique is the introduction of optimally shaped laser pulses to simultaneously enhance sensitivity of explosives signatures while reducing the influence of noise and the signals from background interferents in the field (increase selectivity). These goals are being addressed by operating in an optimal nonlinear fashion, typically with a single shaped laser pulse inherently containing within it coherently locked control and probe ...

2009-01-01

316

New remote sensing techniques for the detection and quantification of earth surface CO2 degassing  

British Library Electronic Table of Contents (United Kingdom)

Earth degassing specifically of carbon dioxide CO2 is of increasing interest with respect to the global carbon budget, related climate effects, earthquake and volcano eruption mechanisms, as well as plant physiological reactions in gas-rich environments. Investigations in all of these disciplines require the detection of surface CO2 degassing structures and quantification of their emissions. We introduce minimal thermal change detection based on infrared imaging as a new remote sensing tool for the detection of earth surface thermal anomalies suiting among others to discover earth degassing locations of any origin. The method allows for seamless areal search and monitoring of degassing structures in any terrain. As proof of concept infrared imaging measurements were performed at the Bossol...

2008-01-01

317

Nato SCI-12 on Camouflage Evaluation Workshop on Search and Target ...  

Science.gov (United States)

Nato SCI-12 on Camouflage Evaluation Workshop on Search and Target Acquisition The Netherlands, June 1999. Image Discrimination Models for Object Detection ...

318

Molecular spectroscopy and planetary atmospheres  

Energy Technology Data Exchange (ETDEWEB)

With the improvements accomplished during the past 15 years in detection techniques and instrumentation and with the opening of space exploration, molecular spectroscopy has become a very efficient way to probe planetary atmospheres.

1984-01-01

319

Modular Traffic Sign Recognition applied to on-vehicle real-time visual detection of American and European speed limit signs  

CERN Document Server

We present a new modular traffic signs recognition system, successfully applied to both American and European speed limit signs. Our sign detection step is based only on shape-detection (rectangles or circles). This enables it to work on grayscale images, contrary to most European competitors, which eases robustness to illumination conditions (notably night operation). Speed sign candidates are classified (or rejected) by segmenting potential digits inside them (which is rather original and has several advantages), and then applying a neural digit recognition. The global detection rate is ~90% for both (standard) U.S. and E.U. speed signs, with a misclassification rate 150 minutes of video. The system processes in real-time ~20 frames/s on a standard high-end laptop.

2009-01-01

320

Lightning Detection for an Air Force Automated Observation ...  

Science.gov (United States)

... of six lightning warning systems was carried out in 1979 as a result of lightning-induced premature explosions in open-pit mining operations. ...

1988-06-08

321

Laser application in the fabrication of gas-tagged capsules. A leak detection system  

Energy Technology Data Exchange (ETDEWEB)

Encapsulation of a unique isotopic blend of krypton and xenon gas employs a special application of laser technology. The encapsulated gas is then used as the primary medium for detection and identification of failed nuclear fuel rods. The use of gas tagging as a means of detecting and identifying failed nuclear fuel rods has been successfully demonstrated and used by the Argonne National Laboratory, Experimental Breeder Reactor (EBR-2) Project, and the Westinghouse Hanford Company (WHC), Fast Flux Test Facility (FFTF) Fast Breeder Reactor Program. The Power Reactor and Nuclear Fuel Development Corporation (PNC) of Japan has selected this leak detection system for use in their MONJU Prototype Reactor fuel assemblies. The MONJU reactor is almost identical in design to the highly successful FFTF reactor, which is currently in standby status.

1993-12-01

322

Kepler: Transit Detection - Kepler - NASA  

Science.gov (United States)

Nov 12, 2010 ... The adaptive, nonparametric matched filter algorithm suggested by Kay ... For the point design of a 4 sigma single event SNR the combined NR ...

323

Imaging oxygenation of human tumours  

UK PubMed Central (United Kingdom)

Tumour hypoxia represents a significant challenge to the curability of human tumours leading to treatment resistance and enhanced tumour progression. Tumour hypoxia can be detected by non-invasive and...Full Text Available

2007-04-01

324

Idaho National Laboratory Supervisory Control and Data Acquisition Intrusion Detection System (SCADA IDS)  

Energy Technology Data Exchange (ETDEWEB)

Current Intrusion Detection System (IDS) technology is not suited to be widely deployed inside a Supervisory, Control and Data Acquisition (SCADA) environment. Anomaly- and signature-based IDS technologies have developed methods to cover information technology-based networks activity and protocols effectively. However, these IDS technologies do not include the fine protocol granularity required to ensure network security inside an environment with weak protocols lacking authentication and encryption. By implementing a more specific and more intelligent packet inspection mechanism, tailored traffic flow analysis, and unique packet tampering detection, IDS technology developed specifically for SCADA environments can be deployed with confidence in detecting malicious activity.

2008-05-01

326

GTMO Portfolio - IRAD Funded - NASA  

Science.gov (United States)

Apr 27, 2007... Bruce Gentry: Small, Efficient Direct Detection Doppler Receiver for UAV and Spaceborne measurement of Tropospheric Winds ...

327

Evaluation of phenylpiperazines as targeting agents for neuroblastoma.  

UK PubMed Central (United Kingdom)

The potential of radiolabelled phenylpiperazines as agents for the detection and therapy of tumours of neural crest origin was evaluated by in vitro pharmacological studies with human neuroblastoma...Full Text Available

1996-09-01

328

Efficient Proximity Detection among Mobile Users via SelfTuning Policies  

DEFF Research Database (Denmark)

Given a set of users, their friend relationships, and a distance threshold per friend pair, the proximity detection problem is to find each pair of friends such that the Euclidean distance between them is within the given threshold. This problem plays an essential role in friend-locator applications and massively multiplayer online games. Existing proximity detection solutions either incur substantial location update costs or their performance does not scale well to a large number of users. Motivated by this, we present a centralized proximity detection solution that assigns each mobile client with a mobile region. We then design a self-tuning policy to adjust the radius of the region automatically, in order to minimize communication cost. In addition, we analyze the communication cost of our solutions, and provide valuable insights on their behaviors. Extensive experiments suggest that our proposed solution is efficient ...

2010-01-01

329

Diagnostic Value of C-reactive Protein in Complicated Appendicitis  

UK PubMed Central (United Kingdom)

PurposeEarly detection of appendicitis has increased due to development of computed tomography and ultrasonography, yet we are frequently meeting complicated appendicitis, including...Full Text Available

2011-06-01

330

Development of a microarray for identification of pathogenic Clostridium species  

UK PubMed Central (United Kingdom)

In recent years, Clostridium species have rapidly reemerged as human and animal pathogens. The detection and identification of pathogenic Clostridium species...Full Text Available

2010-02-01

333

Detection and Identification of Bacteria by Gas Chromatography1  

UK PubMed Central (United Kingdom)

Ether extracts of cultures of 29 strains representing 6 species of Bacillus, and of individual strains of Escherichia coli, Aerobacter aerogenes, and Pseudomonas...Full Text Available

1966-07-01

334

DNA Hypermethylation Patterns Detected in Serum as a Tool ...  

Science.gov (United States)

... Grant support: National Cancer Institute Center grant CA 16087 and National Cancer Institute grant CA091892, Department of Defense grant ...

2009-09-01

335

Control rod drives  

International Nuclear Information System (INIS)

Purpose: To secure the reactor operation safety by the provision of a fluid pressure detecting section for control rod driving fluid and a control rod interlock at the midway of the flow pass for supplying driving fluid to the control rod drives. Constitution: Between a driving line and a direction control valve are provided a pressure detecting portion, an alarm generating device, and a control rod inhibition interlock. The driving fluid from a driving fluid source is discharged by way of a pump and a manual valve into the reactor in which the control rods and reactor fuels are contained. In addition, when the direction control valve is switched and the control rods are inserted and extracted by the control rod drives, the pressure in the driving line is always detected by the pressure detection section, whereby if abnormal pressure is resulted, the alarm generating device is actuated to warn the ...

336

Concurrent Error-Detecting Codes for Arithmetic Processors  

Science.gov (United States)

2 is self-checking as described by Kolupaev. (ref. 21). ..... Kolupaev, S. G.: Self-Testing Residue. Trees. TR-49, Digital Systems ...

337

Comparison of media and methods for detecting and enumerating Listeria monocytogenes in refrigerated cabbage.  

Science.gov (United States)

Direct plating, selective enrichment, and cold enrichment followed by secondary selective enrichment procedures were compared for detecting and enumerating Listeria monocytogenes in chopped cabbage stored at 5 degrees C for up to 64 days. Addition of Fe3+ to solid media enhanced detection of the organism. Cold enrichment (5 degrees C) in nutrient broth and brain heart infusion broth followed by secondary enrichment (48 h, 30 degrees C) in Trypticase soy-yeast extract-antibiotic broth and thiocyanate-nalidixic acid broth and plating on selective agar media (Doyle and Schoeni selective enrichment agar [minus acriflavin hydrochloride, supplemented with 5 micrograms of Fe3+/ml] and McBride Listeria agar) resulted in the detection of highest populations. PMID:3111369

1987-05-01

338

Comparison of fluorescence in situ hybridisation using peptide nucleic acid probes, Gram stain/acridine orange leukocyte cytospin and differential time to positivity methods for detection of catheter related bloodstream infection in patients after haematopoietic stem cell transplantation  

British Library Electronic Table of Contents (United Kingdom)

Abstract In 46 febrile neutropenic patients who had undergone haematopoietic stem cell transplantation, the fluorescence in situ hybridisation using peptide nucleic acid probes (PNA FISH), Gram stain/acridine orange leukocyte cytospin (Gram/AOLC), and differential time to positivity (DTP) methods were performed for detection of catheter related bloodstream infections (CRBSIs). As compared with the DTP method (which detected 11 patients with CRBSI), the PNA FISH and the Gram/AOLC methods detected ten of 11 CRBSI patients, resulting in a sensitivity, specificity, negative predictive value and positive predictive value of 91%, 100%, 97% and 100%, respectively, for the PNA FISH method as well as for the Gram/AOLC method.

2010-01-01

339

Colonoscopy  

Medline Plus

... experts agree-- a colonoscopy is the most accurate test to detect the cancer, but because of cost ... method. Dr. Randall Burt: Colonoscopy is the best test. The question is therefore shouldn't everyone, since ...

340

Center for Intelligent Information Retrieval  

Science.gov (United States)

evaluation, novelty detection, resource discovery, interfaces and visualization, digital libraries, computational social science, and cross-lingual information retrieval. The CIIR...

2011-08-31

341

Biodiversity of Vibrios  

UK PubMed Central (United Kingdom)

Vibrios are ubiquitous and abundant in the aquatic environment. A high abundance of vibrios is also detected in tissues and/or organs of various marine algae and animals, e.g., abalones, bivalves, corals,...Full Text Available

2004-09-01

342

Bacterial body plans  

UK PubMed Central (United Kingdom)

The bacterium Serratia marcescens produces a plethora of multicellular shapes of different colorations on solid substrates, allowing immediate visual detection of varieties. Such a...Full Text Available

2008-07-01

343

Asymmetric Totally-corrective Boosting for Real-time Object Detection  

CERN Document Server

Real-time object detection is one of the core problems in computer vision. The cascade boosting framework proposed by Viola and Jones has become the standard for this problem. In this framework, the learning goal for each node is asymmetric, which is required to achieve a high detection rate and a moderate false positive rate. We develop new boosting algorithms to address this asymmetric learning problem. We show that our methods explicitly optimize asymmetric loss objectives in a totally corrective fashion. The methods are totally corrective in the sense that the coefficients of all selected weak classifiers are updated at each iteration. In contract, conventional boosting like AdaBoost is stage-wise in that only the current weak classifier's coefficient is updated. At the heart of the totally corrective boosting is the column generation technique. Experiments on face detection show that our methods outperform the ...

2010-01-01

344

Adult and child malaria mortality in India  

UK PubMed Central (United Kingdom)

SummaryBackgroundMalaria, a non-fatal disease if detected promptly and treated properly, still causes many deaths in malaria-endemic countries with...Full Text Available

2010-11-20

345

Adaptive Waveform Correlation Detectors for Arrays: Algorithms for Autonomous Calibration  

Energy Technology Data Exchange (ETDEWEB)

Waveform correlation detectors compare a signal template with successive windows of a continuous data stream and report a detection when the correlation coefficient, or some comparable detection statistic, exceeds a specified threshold. Since correlation detectors exploit the fine structure of the full waveform, they are exquisitely sensitive when compared to power (STA/LTA) detectors. The drawback of correlation detectors is that they require complete knowledge of the signal to be detected, which limits such methods to instances of seismicity in which a very similar signal has already been observed by every station used. Such instances include earthquake swarms, aftershock sequences, repeating industrial seismicity, and many other forms of controlled explosions. The reduction in the detection threshold is even greater when the techniques are applied to arrays since stacking can be performed on the ...

2009-07-23

346

A Dose- and Time-Controllable Syngeneic Animal Model of Breast Cancer Microcalcification  

UK PubMed Central (United Kingdom)

IntroductionThe development of novel diagnostic agents for the detection of breast cancer microcalcifications requires a reliable animal model. Based on previous...Full Text Available

2010-07-01

347
348

8 - NASA Technical Report Server (NTRS)  

Science.gov (United States)

feature similar to the face detection in Intel's OpenCV library, implement it in Matlab code, and test the performance of the new ROI detector against the ...

349

Preparatory Signal Detection for Annex I Countries under the Kyoto Protocol. A Lesson for the Post-Kyoto Policy Process  

Energy Technology Data Exchange (ETDEWEB)

The focus of this study is on the preparatory detection of uncertain net greenhouse gas (GHG) emission changes (also termed emission signals) under the Kyoto Protocol. The crucial question to be addressed is: How well do we need to know net emissions if we want to detect a specified emission signal after a given time? No restrictions exist as to what concerns the net emitter, which may be any GHG source or sink. Annex I countries are chosen as net emitters, simply for reasons of data availability and because of the excellent possibility of comparing net emitters (inter-country comparison). The countries' emissions - in an increasing number of cases even their uncertainties - are available permitting the application of preparatory signal detection techniques, which are suited to address the aforementioned question. We currently discuss four hierarchically-ordered detection concepts to assess ...

2004-06-14

350

[Development of efficient DNA isolation procedures for Cryptosporidium and Trichinella PCR detection in fecal samples].  

Science.gov (United States)

PCR detection of genetic material of the parasites present in faeces may be an alternative for microscopic and serological tests routinely used for diagnosing parasitic enteral infections. However, small amount of target DNA combined with low efficiency of total DNA extraction, and presence of PCR inhibitors in the samples to be amplified, may cause false negative detection results. The aim of this work was to evaluate the impact of DNA isolation procedure used on the amplification of DNA fragments from the genomes of protozoan Cryptosporidium parvum and the nematode Trichinella spiralis. Two methods based on different principles of biological material lysis were evaluated; NucliSENS miniMAG employing simultaneously applied chemical lysis and mechanical disruption or mechanical disruption followed by enzymatic lysis in case of QIAamp DNA Stool Mini Kit. Both of the analyzed systems for nucleic acids purification allowed isolation of DNA from ...

2009-01-01

351

The detection and characterization of natural fractures using P-wave reflection data, multicomponent VSP, borehole image logs and the in-situ stress field determination  

Energy Technology Data Exchange (ETDEWEB)

The objectives of this project are to detect and characterize fractures in a naturally fractured tight gas reservoir, using surface seismic methods, borehole imaging logs, and in-situ stress field data. Further, the project aims to evaluate the various seismic methods as to their effectiveness in characterizing the fractures, and to formulate the optimum employment of the seismic methods as regards fracture characterization.

1995-04-01

352

Study of cosmic ray nuclei detection by an image calorimeter  

Energy Technology Data Exchange (ETDEWEB)

It is shown that a cosmic gamma-ray telescope made of a multilayer silicon tracker and a imaging CsI calorimeter, is capable of identifying cosmic ray nuclei. The telescope charge resolution is estimated around 4% independently of charge. Simulation methods are used to determine the telescope properties for nuclei detection.

1995-09-01

353

Spectroscopic detection  

Energy Technology Data Exchange (ETDEWEB)

In embodiments, spectroscopic monitor monitors modulated light signals to detect low levels of contaminants and other compounds in the presence of background interference. The monitor uses a spectrometer that includes a transmissive modulator capable of causing different frequency ranges to move onto and off of the detector. The different ranges can include those with the desired signal and those selected to subtract background contributions from those with the desired signal. Embodiments of the system are particularly useful for monitoring metal concentrations in combustion effluent.

2003-01-01

354

Simultaneous Detection of Multiplex-Amplified Human Immunodeficiency Virus Type 1 RNA, Hepatitis C Virus RNA, and Hepatitis B Virus DNA Using a Flow Cytometer Microsphere-Based Hybridization Assay  

UK PubMed Central (United Kingdom)

The feasibility of performing a multiplex assay for the detection of human immunodeficiency virus type 1 (HIV-1) and hepatitis C virus (HCV) RNAs and hepatitis B virus (HBV) DNA is demonstrated. This...Full Text Available

2000-03-01

355

Sensitive enzyme immunoassay for detecting immunoglobulin M antibodies to Sindbis virus and further evidence that Pogosta disease is caused by a western equine encephalitis complex virus.  

UK PubMed Central (United Kingdom)

An antibody capture enzyme immunoassay (EIA) was adapted for the detection of immunoglobulin M (IgM) antibody to Sindbis (SIN) virus. Sera from humans with a febrile illness characterized by rash and...Full Text Available

1985-10-01

356

Roentgenologic appearance of a thorotrast-induced small cholangiocarcinoma in a case of thorotrastosis  

International Nuclear Information System (INIS)

A small cholangiocarcinoma was detected at autopsy in a patient with thorotrastosis who died from the rupture of esophageal varices at the esophagogastric junction. Prior to the advent of recent diagnostic imaging technique, a correct antemortem diagnosis could only be obtained from tumor markers. However, the tendency for the opacity of the liver to decrease slowly with time and develop uneven trabeculation suggests that small tumors may be difficult to detect against such a non-homogeneous background. (author).

357

Research - Keyword Index  

Wastenet

...notice de en es fr it nl European Commission Research Index aeronews All keywords Index feedback The number of documents that contain the keyword aeronews is: 1 EU Transport lsquo;AERONEWSrsquo; -good news for early detection of microdamage European Commission - lsquo;AERONEWSrsquo; -good news for early detection of microdamage ...

358

Rapid and Inexpensive Detection of Multidrug-Resistant Mycobacterium tuberculosis with the Nitrate Reductase Assay Using Liquid Medium and Direct Application to Sputum Samples?  

UK PubMed Central (United Kingdom)

For rapid and low-cost detection of multidrug-resistant (MDR) Mycobacterium tuberculosis, we applied the nitrate reductase assay (NRA) using a liquid medium directly to sputum samples....Full Text Available

2008-10-01

359

Radiation treatment of crude drugs. Development of suitable methods of detection. Strahlenbehandlung von Arzneidrogen. Entwicklung geeigneter Nachweismethoden  

Energy Technology Data Exchange (ETDEWEB)

It may be necessary to reduce microbiological contamination of crude drugs (medicinal plants or their parts like roots, leaves, flowers). This can be done by treating the drugs with ionizing radiation. Meethods for detection of such an irradiation were developed. It could be pointed out that measurements of luminescence, viscosity and electron spin resonance were suitable for specific drugs, but not for all drugs. (orig.).

1992-09-01

360

Proceedings, third international symposium on mine mechanization and automation  

Energy Technology Data Exchange (ETDEWEB)

Papers are presented under the following topics: machine control and automation; rock drilling; cutting and fragmentation; rock characterization, remote sensing and interface detection; artificial intelligence and mine monitoring systems; computer applications; mechanical excavators; material handling; surface and underground mining; innovative mining systems; new developments in mechanical miners; ground hazard detection and control; ground support; and extraterrestrial mining.

1995-12-31

361

Plagiarism Detection in arXiv  

CERN Document Server

We describe a large-scale application of methods for finding plagiarism in research document collections. The methods are applied to a collection of 284,834 documents collected by arXiv.org over a 14 year period, covering a few different research disciplines. The methodology efficiently detects a variety of problematic author behaviors, and heuristics are developed to reduce the number of false positives. The methods are also efficient enough to implement as a real-time submission screen for a collection many times larger.

2007-01-01

362

Particle identification by modified Bragg-curve centroid detection  

Energy Technology Data Exchange (ETDEWEB)

A new article identification method based on the measurement of Bragg-curve centroids using a gas-filled ionization chamber has been improved for detection of low-energy particles around 1 MeV per nucleon by introducing a nonuniform distribution of resistance on the anode electrode. Almost the same quality of Z-resolutions as in the conventional ..delta..E-E method could be obtained up to Z=19.

1987-03-01

363

Optic probe for semiconductor characterization  

Energy Technology Data Exchange (ETDEWEB)

Described herein is an optical probe (120) for use in characterizing surface defects in wafers, such as semiconductor wafers. The optical probe (120) detects laser light reflected from the surface (124) of the wafer (106) within various ranges of angles. Characteristics of defects in the surface (124) of the wafer (106) are determined based on the amount of reflected laser light detected in each of the ranges of angles. Additionally, a wafer characterization system (100) is described that includes the described optical probe (120).

2008-09-02

364

Multi-spectral schottky barrier infrared radiation detection array  

Energy Technology Data Exchange (ETDEWEB)

A multi-spectral Schottky barrier infrared detector array in which individual pixels of radiation from a remote radiating object are detected by two or more Schottky barrier infrared radiation detectors each having a different spectral response so as to provide a ''color'' discrimination for the array.

1983-12-27

365

Multi-spectral schottky barrier infrared radiation detection array  

International Nuclear Information System (INIS)

A multi-spectral Schottky barrier infrared detector array in which individual pixels of radiation from a remote radiating object are detected by two or more Schottky barrier infrared radiation detectors each having a different spectral response so as to provide a ''color'' discrimination for the array.

366

Movable genetic elements: detection of changes in maize DNA at the Shrunken locus due to the intervention of Ds elements  

Science.gov (United States)

This report describes our initial attempts at the molecular characterization of a maize controlling element. We have prepared a cDNA probe and used it to detect changes at a locus where Ds elements are found. Evidence of their presence are indicated by changes in the restriction patterns, but there is as yet no information on the physical nature of the controlling elements nor on the kinds of rearrangements they cause.

1980-05-28

367

Method and apparatus for detecting explosives  

Energy Technology Data Exchange (ETDEWEB)

A method and apparatus is provided for detecting explosives by thermal imaging. The explosive material is subjected to a high energy wave which can be either a sound wave or an electromagnetic wave which will initiate a chemical reaction in the explosive material which chemical reaction will produce heat. The heat is then sensed by a thermal imaging device which will provide a signal to a computing device which will alert a user of the apparatus to the possibility of an explosive device being present.

2011-05-10

368

Metastasis Detection in Sentinel Lymph Nodes: Comparison of a Limited Widely Spaced (NSABP protocol B-32) and a Comprehensive Narrowly Spaced Paraffin Block Sectioning Strategy  

UK PubMed Central (United Kingdom)

The NSABP B-32 trial is examining whether patients with initially negative sentinel lymph nodes (SLNs) who have occult metastases detected on deeper levels and cytokeratin immunohistochemistry...Full Text Available

2009-11-01

369

Inguino-scrotal hernia detection in the early phase of a bone scan  

International Nuclear Information System (INIS)

A large inguino-scrotal hernia was detected in the early phase of a radionuclide bone scan performed for evaluation of a femoral neck fracture not visualized on plain x-rays. The patient was administered 1 GBq of Scrotal scintigraphy using "9"9"mTc-MDP and a regional three-phase bone scan of the pelvis, hips and proximal femora was obtained on the gamma camera. Copyright (1999) Blackwell Science Pty Ltd

1999-11-01

370

Gamma ray detecting device using dislocation-free crystal  

Energy Technology Data Exchange (ETDEWEB)

This patent describes a {gamma}-ray detector. It comprises: a dislocation-free single crystal having an input surface and a transmission surface at opposite ends thereof; an active shield surrounding the crystal and functioning as an anticoincidence counter; and {gamma}-ray detector means disposed adjacent the transmission surface of the crystal for receiving and detecting {gamma}-rays of a predetermined wavelength incident on the input surface of the crystal at a specific Bragg angle and transmitted through the crystal.

1991-04-30

371

GaAs detector optimization for different medical imaging applications  

International Nuclear Information System (INIS)

We have investigated the detection performance of GaAs detectors made with different thickness and contact geometries. A comparison is made between these detection capabilities and the imaging requirements for the following medical applications: digital mammography, digital chest radiography and nuclear medicine. Experimental results and preliminary images are presented and discussed. (author)

1999-09-11

372

Fault prediction on high voltage transmission lines  

Energy Technology Data Exchange (ETDEWEB)

The prediction of faults on high voltage transmission lines requires the detection of incipient faults, which is implemented by detection of the radio noise due to contaminated insulators, insulation deterioration, and improver connections. It is shown that the radio noise due to incipient faults is separable and identifiable from normal transmission line radio noise, hence faults can be predicted.

1982-12-01

373

Face recognition based on color model  

Science.gov (United States)

Over the past ten years face segmentation has developed rapidly and various algorithms have been proposed. In this paper we will demonstrate a face detection system based on skin color and the spaces RGB, normalized RGB, HSV and YCbCr are concentrated here. Through combing them the more accurate face region will be detected.

2011-04-01

374

Evaluation of the Bactec MGIT 960 system in combination with the MGIT TBc identification test for detection of Mycobacterium tuberculosis complex in respiratory specimens.  

Science.gov (United States)

The sensitivity and specificity of the MGIT TBc identification (TBc ID) test for Mycobacterium tuberculosis complex (MTC) detection in positive Bactec MGIT cultures were 95.2% and 99.2%, respectively. When MTC-positive results obtained from two additional molecular methods were included, the sensitivity of the MGIT TBc ID test was 85.4%, while that of culture was 95.7%. PMID:21450949

2011-03-30

375

Earth Matter Effects in Detection of Supernova Neutrinos  

CERN Document Server

We calculated the matter effect, including both the Earth and supernova, on the detection of neutrinos from type II supernovae at the proposed Daya Bay reactor neutrino experiment. It is found that apart from the dependence on the flip probability P_H inside the supernova and the mass hierarchy of neutrinos, the amount of the Earth matter effect depends on the direction of the incoming supernova neutrinos, and reaches the biggest value when the incident angle of neutrinos is around 93^\\circ. In the reaction channel \\bar{\

2006-01-01

376

Detection of polychlorinated biphenyl degradation genes in polluted sediments by direct DNA extraction and polymerase chain reaction  

Energy Technology Data Exchange (ETDEWEB)

It was the aim of this study to specifically detect the DNA sequences for the bphC gene, the meta-cleavage enzyme of the aerobic catabolic pathway for biphenyl and polychlorinated biphenyl degradation, in aquatic sediments without prior cultivation of microorganisms by using extraction of total DNA, PCR amplification of bphC sequences, and detection with specific gene probes. The direct DNA extraction protocol used was modified to enhance lysis efficiency. Crude extracts of DNA were further purified by gel filtration, which yielded DNA that could be used for the PCR. PCR primers were designed for conserved regions of the bphC gene from a sequence alignment of five known sequences. The specificity of PCR amplification was verified by using digoxigenin-labeled DNA probes which were located internal to the amplified gene sequence. The detection limit for the bphC gene of Pseudomonas paucimobilis Q1 and Pseudomaonas sp. strain ...

1993-12-01

377

Detection of pathogenic Yersinia enterocolitica in foods and water by immunomagnetic separation, nested polymerase chain reactions, and colorimetric detection of amplified DNA.  

UK PubMed Central (United Kingdom)

A two-step polymerase chain reaction (PCR) procedure with two nested pairs of primers specific for the yadA gene of Yersinia enterocolitica was developed. The PCR assay identified all common pathogenic...Full Text Available

1993-09-01

378

Detection of drugs and explosives using neutron computerized tomography and artificial intelligence techniques  

International Nuclear Information System (INIS)

In this study the development of a methodology to detect illicit drugs and plastic explosives is described with the objective of being applied in the realm of public security. For this end, non-destructive assay with neutrons was used and the technique applied was the real time neutron radiography together with computerized tomography. The system is endowed with automatic responses based upon the application of an artificial intelligence technique. In previous tests using real samples, the system proved capable of identifying 97% of the inspected materials.

2010-06-01

379

Detection of aortoarterial graft infections by leukocyte scintigraphy  

Energy Technology Data Exchange (ETDEWEB)

Infections of aortoarterial prostheses are serious, difficult to detect, and difficult to treat. Scintigraphy with indium-111 labeled autologous leukocytes is an accurate noninvasive method of assessing the presence and extent of such an infection. In three cases of aorto-arterial bypass graft infections, the leukocyte study was successful in establishing the diagnosis and in assessing the extent of infection. Other noninvasive diagnostic techniques are useful, but all have serious limitations. The leukocyte study alone appears to be free of likely sources of error.

1983-09-01

380

Comparison of C18-Carboxypropylbetaine and Glass Bead DNA Extraction Methods for Detection of Mycobacterium bovis in Bovine Milk Samples and Analysis of Samples by PCR  

UK PubMed Central (United Kingdom)

The purpose of this prospective study was to compare two different milk preparation methods to assay for the presence of Mycobacterium bovis by PCR. Detection by a C18-carboxypropylbetaine...Full Text Available

1998-08-01

381

Comparative evaluation of Computed Tomography and Magnetic Resonance Imaging (1.5 T) in the detection of brain metastases  

International Nuclear Information System (INIS)

Forty-four patients with small cell carcinoma of the bronchus underwent CT and MR studies of the brain to detect cerebral metastases. All patients were studied with contrast-enhanced CT scans, short (T1-weighted) and long (T2-weighted), spin-echo (SE) and FLASH 90 grades sequences were also obtained. A quantitative comparison of the results was carried out to assess the sensitivity of the different techniques in the detection of brain metastases according to lesion diameter. Metastases were identified in 19/44 patients (43%). All techniques detected the lesions >2 cm; of the metastases <2 cm, 63/124 (51%) were detected only by GdDTPA SE-T1 and FLASH sequences and 11 more (9%) only by Gd-DTPA SE-T1 scans. All the lesions identified oh enhanced CT scans or on T2-weighted images were easily detected by Gd-DTPA scans. CT sensitivity was higher than that of pre-contrast SE-T1 and ...

1991-01-01

382

Comparative Study of 125I- and [3H]Acetate-Labeled Antibodies in Detecting Iridescent Viruses  

UK PubMed Central (United Kingdom)

Radioimmunoassays for detecting cell-associated or released virus are described using either 125I- or [3H]acetate-labeled antibodies. In the first assay system, antigen-antibody...Full Text Available

1974-07-01

383

Chemical detection of leukocytes in urine by means of a new multiple test strip.  

Science.gov (United States)

The performance of the leukocyte test area of the new multiple urine test strip, Multistix-10-SG, was evaluated in both field trials and model experiments. The detection limit was found to be adequate for routine purposes. Unspecific reactions are rare and generally indicated by the results of the other test areas. PMID:3572312

1987-02-01

384

Aqueous liquid scintillation counting with fluor-containing nanosuspensions  

Energy Technology Data Exchange (ETDEWEB)

A microemulsion comprised of water, Brij 78, pentanol and styrene into which PPO and bis-MSB had been dissolved was prepared. Polymerization of the styrene resulted in a suspension of fluor-containing polystyrene nanoparticles (<100 nm). After a concentration step, the aqueous nanosuspension was able to detect {sup 14}C with counting efficiencies over 50% of those of a commercially available scintillation cocktail. Monte Carlo calculations demonstrated that the size and concentration of the nanoparticles were appropriate for optimum detection efficiency.

2004-06-01

385

Abundances of s-process elements in planetary nebulae: Br, Kr & Xe  

CERN Document Server

We identify emission lines of post-iron peak elements in very high signal-to-noise spectra of a sample of planetary nebulae. Analysis of lines from ions of Kr and Xe reveals enhancements in most of the PNe, in agreement with the theories of s-process in AGB star. Surprisingly, we did not detect lines from Br even though s-process calculations indicate that it should be produced with Kr at detectable levels.

2006-01-01

386

A rapid and simple DNA extraction procedure to detect Salmonella spp. and Listeria monocytogenes from fresh produce using real-time PCR  

Science.gov (United States)

DNA isolation procedures significantly influence the outcome of PCR-based detection of human pathogens. Unlike clinical samples, DNA isolation from food samples such as fresh and fresh-cut produce has remained a formidable task and has hampered the sensitivity and accuracy of molecular methods. We...

387

A coincidence long baseline celestial gamma-ray burst detection system  

International Nuclear Information System (INIS)

A time coincidence long baseline (250 km) cosmic ray detection system has been developed to search for bursts of high energy #gamma#-rays (E_0>= 10"1"3 eV) of extra-terrestrial origin. The system design incorporates the possibility of simultaneous observation over a variety of time scales between 1 #mu#s and 10 s. (Auth.).

388

The mask detection technology for occluded face analysis in the surveillance system.  

Science.gov (United States)

The surveillance systems have been widely used in automatic teller machines (ATMs), banks, convenient stores, etc. For example, when a customer uses the ATM, the surveillance systems will record his/her face information. The information will help us understand and trace who withdrew money. However, when criminals use the ATM to withdraw illegal money, they usually block their faces with something (in Taiwan, criminals usually use safety helmets or masks to block their faces). That will degrade the purpose of the surveillance system. In previous work, we already proposed a technology for safety helmet detection. In this paper, we propose a mask detection technology based upon automatic face recognition methods. We use the Gabor filters to generate facial features and utilize geometric analysis algorithms for mask detection. The technology can give an early warning to save-guards when any "customer" or "intruder" blocks ...

2005-05-01

389

Radiation Isotope Identification Device (RIIDs) Field Test and Evaluation Campaign  

Energy Technology Data Exchange (ETDEWEB)

Handheld, backpack, and mobile sensors are elements of the Global Nuclear Detection System for the interdiction and control of illicit radiological and nuclear materials. They are used by the U.S. Department of Homeland Security (DHS) and other government agencies and organizations in various roles for border protection, law enforcement, and nonproliferation monitoring. In order to systematically document the operational performance of the common commercial off-the-shelf portable radiation detection systems, the DHS Domestic Nuclear Detection Office conducted a test and evaluation campaign conducted at the Nevada Test Site from January 18 to February 27, 2006. Named 'Anole', it was the first test of its kind in terms of technical design and test complexities. The Anole test results offer users information for selecting appropriate mission-specific portable radiation detection systems. ...

2007-08-01

390

Position of nuclear-medical techniques for evaluation of loosened total hip endroprostheses  

Energy Technology Data Exchange (ETDEWEB)

For diagnosis of loosening or infection after implantation of a single-side or double-side total hip endoprosthesis 59 patients being in pain were investigated by a combination of bone scan (Technetium-99m DPD) and leucocyte scan (Indium-111 labelled leucocytes). The correlation between clinical results and scintigraphic findings revealed: bone scintigraphy detects loosening of prostheses with 95% sensitivity (45/47); bone scintigraphy excludes an instable prosthesis with 89% specificity (3/27). 45% of the loosened prostheses revealed an infection (21/47): leucocyte scintigraphy could detect 17 correct positive. Three leucocyte scans of 53 prostheses without clinical signs of infection were false positive. Therefore, leucocyte scintigraphy had a sensitivity of 91% and a specificity of 94% for detecting infection. Bone scintigraphy can detect loosening of prostheses with 93% accuracy, Indium-111 labelled ...

1985-10-01

391

Modern imaging methods for diagnostic evaluation of tumors of the oropharynx and the oral cavity  

International Nuclear Information System (INIS)

Differentiating a benign from a malignant lesion by information such as density data, or signal intensities or echo gradients, is not possible with CT, nor MRI, nor ultrasonography. Only some lesions show characteristic signs. Inflammations cannot be difscriminated from malignant tumors. CTs of small tumors in particular are so poor in contrast that it is much more difficult to detect tumors or discriminate them from other lesions, as compared to MR images or ultrasonographs. CT does not detect surface tumors, but is more sensitive than MRI or US in detecting discrete cortical bone lesions. The same applies to small calcified tumors. MRI however is most sensitive in detecting tumor volumes in the yellow marrow, and is the best modality for evaluation of extraossal extension of tumors. CT yields better results than MRI if applied for simultaneous screening of lymph node metastases in the lower neck. MRI ...

392

Improvement of detectability for circumferential crack of Steam Generator tube by eddy current and ultrasonic testing method  

International Nuclear Information System (INIS)

Steam Generator (SG) tubes in PWR plant are periodically inspected using eddy current testing (ECT) method. In Japan, bobbin coil type dual function probe is used for full length inspection, but the detectability for circumferential crack is very poor, and to improve detectability for circumferential crack and supplement regular ECT, various kinds of multi segment eddy current probes and multi transducer ultrasonic testing (UT) method have been developed. ECT probes are constructed of multiple surfaceriding special winding differential type coils and UT probe consists of 16 transducers which are spaced equally around the probe circumference for 360deg wall coverage. Both of those EC and UT probes are designed effective to detect circumferential crack. On the other hand, various kinds of laboratory induced circumferential cracks have been made and destroyed to prove the detectability of these probes. ...

1991-08-01

393

Enhanced defect detection and sizing accuracy using matrix phased array ultrasonic tools  

Energy Technology Data Exchange (ETDEWEB)

Although ultrasonic testing inspection technology and tools have improved significantly, there is still a need for more reliable detection, monitoring, and accurate sizing of crack-like and planar defects, complex corrosion damage, and detection of secondary features within deformed pipe. Ultrasonic two dimensional (2D) matrix phased array technology offers some unique advantages that make the technology promising for improving detection and sizing of pipeline flaws resulting from welding or from in-service damage. Ultrasonic modeling and simulation has been conducted to evaluate the detection and sizing capabilities of 2D matrix arrays for various pipeline inspection concepts. Simulations have been performed using both flexible and rigid array probes. Inspection concepts using rigid probes were evaluated for inspections from both the outside and inside pipe surfaces, while flexible probes were ...

2009-07-01

394

Detection system characteristics using sup 252 Cf ionization chambers  

Energy Technology Data Exchange (ETDEWEB)

Because the number of neutrons and gamma rays and the energy spectrum of particles from spontaneous fission are well characterized for {sup 252}Cf, it can be used as a timed source of fission neutrons and gamma rays. The first such usage incorporated a {sup 252}Cf source into gas scintillators. This paper describes a timed source of neutrons and gamma rays made by depositing {sup 252}Cf on one electrode of a parallel plate ionization chamber that can then be used for determining detection-system characteristics. The emission time of neutrons from spontaneous fission has also been determined by recording the emission time of prompt gamma rays from a {sup 252}Cf source (not incorporated into a detector) adjacent to the surface of a solid or liquid scintillator. This well characterized source of neutrons can thus be used as a randomly pulsed source for a variety of applications. This paper illustrates the use of this type of source to determine the time resolution of ...

1990-01-01

395

Detection of explosives  

Energy Technology Data Exchange (ETDEWEB)

An analyser for detecting explosives has at least one neutron source and a plurality of gamma ray detectors. An article to be analysed is moved adjacent the source and detectors and is subjected to neutrons which generate gamma rays from any nitrogen in the article. The gamma rays are detected and analysed to determine the nitrogen concentration within the article. In order to achieve an area of uniform detection there are a plurality of detectors equidistant both from the or each source and from the article to be analysed. In order to avoid a decrease in sensitivity away from the source(s) and detectors there may be a second opposing array of source(s) and detectors on the opposite side of the article. For greatest uniformity of detection, a source in one array opposes a detector in the other array and vice versa. Transmission of radiation from the analyser is kept at safe levels by enclosing the ...

1991-03-13

396

Coated semiconductor devices for neutron detection  

Energy Technology Data Exchange (ETDEWEB)

A device for detecting neutrons includes a semi-insulated bulk semiconductor substrate having opposed polished surfaces. A blocking Schottky contact comprised of a series of metals such as Ti, Pt, Au, Ge, Pd, and Ni is formed on a first polished surface of the semiconductor substrate, while a low resistivity ("ohmic") contact comprised of metals such as Au, Ge, and Ni is formed on a second, opposed polished surface of the substrate. In one embodiment, n-type low resistivity pinout contacts comprised of an Au/Ge based eutectic alloy or multi-layered Pd/Ge/Ti/Au are also formed on the opposed polished surfaces and in contact with the Schottky and ohmic contacts. Disposed on the Schottky contact is a neutron reactive film, or coating, for detecting neutrons. The coating is comprised of a hydrogen rich polymer, such as a polyolefin or paraffin; lithium or lithium fluoride; or a heavy metal fissionable material. By varying the coating thickness and ...

2002-01-01

397

Characterization of 3D thermal neutron semiconductor detectors  

International Nuclear Information System (INIS)

Neutron semiconductor detectors for neutron counting and neutron radiography have an increasing importance. Simple silicon neutron detectors are combination of a planar diode with a layer of an appropriate neutron converter such as 6LiF. These devices have limited detection efficiency of not more than 5%. The detection efficiency can be increased by creating a 3D microstructure of dips, trenches or pores in the detector and filling it with a neutron converter. The first results related to the development of such devices are presented. Silicon detectors were fabricated with pyramidal dips on the surface covered with 6LiF and then irradiated by thermal neutrons. Pulse height spectra of the energy deposited in the sensitive volume were compared with simulations. The detection efficiency of these devices was about 6.3%. Samples with different column sizes were fabricated to study the electrical properties of 3D structures. ...

2007-06-11

398

A proposal for prevention of acute radiation hazard and social panic regarding orphan sources in Japan  

International Nuclear Information System (INIS)

To respond to an increase of social problems concerning orphan sources in Japan, a working group was formed in the Japan Health Physics Society. In this working group, we investigated how to prevent acute radiation hazard or social panic regarding orphan sources in scrap metal and detection system for orphan sources brought into scrap yards before recycle. For detection system in a scrap yard we conducted an experiment on detectability of monitoring instrument using a radiation source mixed in scrap metal on a truck. The result showed that it was not easy to detect even a high-level source if it was shielded by scrap metal. We also estimated detection limits for radioactive materials in scrap metal by calculation that was validated with experimental data. We summarized present status about orphan sources in Japan and proposed a categorization of orphan sources according to dose ...

2002-10-20

399

A multi-marker model for detecting chromosomal segments displaying QTL activity  

Science.gov (United States)

A statistical method is presented for detecting quantitative trait loci (QTLs), based on the linear model. Unlike methods able to detect a few well separated QTLs and to estimate their effects and positions, this method considers the genome as a whole and enables the detection of chromosomal segments involved in the differences between two homozygous lines, and their backcross, doubled haploid, or F[sub 2] progenies, for a quantitative trait. Genetic markers must be codominant, but missing markers are accepted, provided they are missing independently from the experiment. Asymptotic properties, which are of practical use, are developed. This method does not rely on strong genetic hypotheses, and thus does not permit any precise genetic analysis of the trait under study, but it does assess which regions of the genome are involved, whatever the complexity of the genetic determinism (number, effects and interactions among ...

1993-08-01

400

Variations in humanized and defined culture conditions supporting derivation of new human embryonic stem cell lines  

DEFF Research Database (Denmark)

The evolution of "humanized" (i.e., free of animal sourced reagents) and ultimately chemically defined culture systems for human embryo stem cell (hESC) isolation and culture is of importance to improving their efficacy and safety in research and therapeutic applications. This can be achieved by integration of a multitude of individual approaches to replace or eliminate specific animal sourced reagents into a single comprehensive protocol. In the present study our objective was to integrate strategies obviating reliance on some of the most poorly defined and path-critical factors associated with hESC derivation, namely the use of animal immune compliment to isolate embryo inner cell mass, and animal sourced serum products and feeder cells to sustain hESC growth and attachment. As a result we report the derivation of six new hESC lines isolated by outgrowth from whole blastocysts on an extracellular matrix substrate of purified human laminin (Ln) with transitional reliance on ...

2006-01-01

401

Tissue culture and micropropagation for forest biomass production  

Energy Technology Data Exchange (ETDEWEB)

An increase in forest production will be necessary in the future when wood becomes a major renewable source of energy and chemicals along with its traditional role of fibre source. This increase could eventually by achieved be proper selection and breeding of trees. Clonal forestry by vegetative propagation of cuttings is becoming a viable alternative to a seedling-based forestry with many advantages, and cutting could be used to quickly propagate large numbers of clones of control-pollinated seedlings. Most forest trees are propagated sexually and seed orchards were started in the US and Canada in the last 40-50 years for breeding purposes. Forests could ultimately be established with improved seedlings instead of from seed with unknown genetic potential, or by natural regeneration. Micropropagation is the term used to refer to the propagation of plants raised by tissue culture methods rather than from seeds or cuttings. Many clonal plantlets could be regenerated asexually in the ...

1984-09-01

402

The ternary silicide ZrPd{sub 3}Si{sub 3}, a stacking variant of the {alpha}-FeSi{sub 2} and Re{sub 3}B structure types  

Energy Technology Data Exchange (ETDEWEB)

The ternary zirconium palladium silicide ZrPd{sub 3}Si{sub 3} has been synthesized by arc-melting of the elemental components. It adopts a new structure type and crystallizes in the orthorhombic space group Cmcm with a = 3.8127(4){angstrom}, b = 15.551(1){angstrom}, c = 7.0390(5){angstrom}, and Z = 4 (Pearson symbol oC28). The structure can be regarded as being built up of Re{sub 3}B-type slabs of composition Pd{sub 3}Si alternating with {alpha}-FeSi{sub 2} slabs of composition ZrSi{sub 2}. Notable features include the presence of Si{sub 2} pairs, square pyramidal and tetrahedral coordination of Pd centers by Si atoms, an unusual distorted cubic coordination of the Zr atoms by the Si{sub 2} pairs, and an extensive network of Zr-Zr, Zr-Pd, and Pd-Pd metal-metal bonds. ZrPd{sub 3}Si{sub 3} is weakly metallic with a room-temperature resistivity of 1.7 x 10{sup {minus}3} {Omega} cm. Extended Hueckel band structure calculations confirm the metallic behavior; support the simultaneous ...

1999-11-01

403

The retinoic acid receptor beta (Rarb) region of Mmu14 is associated with prion disease incubation time in mouse.  

Science.gov (United States)

In neurodegenerative conditions such as Alzheimer's and prion disease it has been shown that host genetic background can have a significant effect on susceptibility. Indeed, human genome-wide association studies (GWAS) have implicated several candidate genes. Understanding such genetic susceptibility is relevant to risks of developing variant CJD (vCJD) in populations exposed to bovine spongiform encephalopathy (BSE) and understanding mechanisms of neurodegeneration. In mice, aspects of prion disease susceptibility can be modelled by examining the incubation period following experimental inoculation. Quantitative trait linkage studies have already identified multiple candidate genes; however, it is also possible to take an individual candidate gene approach. Rarb and Stmn2 were selected as candidates based on the known association with vCJD. Because of the increasing overlap described between prion and Alzheimer's diseases we also chose Clu, Picalm and Cr1, which ...

2010-12-06

404

The economic limits of in situ leach mining  

International Nuclear Information System (INIS)

Different technological procedures used for the chemical mining of uranium differ for one thing with a level of the deposit exploitation and for another with the expenditures. It is necessary to find out the highest acceptable value of the costs per unit of production - limit unit costs. This criterion serves both for selection of the minable parts of deposit, and for determination of the exploitation level of the deposit parts. The paper describes a calculation of the costs and their decomposition into the fixed and variable costs. An evaluation of the different variants of the deposit exploitation is based on the variable costs, expressed in the dependence on the parameters of technological procedure. These parameters are either primary, e.g. density of the wells or dosage of reagents, or secondary, e.g. the uranium production. A relation between primary and secondary variables is defined by the technological models. The first economic optimization calculations ...

2002-03-01

405

Strikingly different penetrance of LHON in two Chinese families with primary mutation G11778A is independent of mtDNA haplogroup background and secondary mutation G13708A  

Energy Technology Data Exchange (ETDEWEB)

The penetrance of Leber's hereditary optic neuropathy (LHON) in families with primary mitochondrial DNA (mtDNA) mutations is very complex. Matrilineal and nuclear genetic background, as well as environmental factors, have been reported to be involved in different affected pedigrees. Here we describe two large Chinese families that show a striking difference in the penetrance of LHON, in which 53.3% and 15.0% of members were affected (P < 0.02), respectively. Analysis of the complete mtDNA genome of the two families revealed the presence of the primary mutation G11778A and several other variants suggesting the same haplogroup status G2a. The family with higher penetrance contained a previously described secondary mutation G13708A, which presents a polymorphism in normal Chinese samples and does not affect in vivo mitochondrial oxidative metabolism as described in a previous study. Evolutionary analysis failed to indicate any putatively pathogenic ...

2008-08-25

406

Strikingly different penetrance of LHON in two Chinese families with primary mutation G11778A is independent of mtDNA haplogroup background and secondary mutation G13708A  

International Nuclear Information System (INIS)

The penetrance of Leber's hereditary optic neuropathy (LHON) in families with primary mitochondrial DNA (mtDNA) mutations is very complex. Matrilineal and nuclear genetic background, as well as environmental factors, have been reported to be involved in different affected pedigrees. Here we describe two large Chinese families that show a striking difference in the penetrance of LHON, in which 53.3% and 15.0% of members were affected (P < 0.02), respectively. Analysis of the complete mtDNA genome of the two families revealed the presence of the primary mutation G11778A and several other variants suggesting the same haplogroup status G2a. The family with higher penetrance contained a previously described secondary mutation G13708A, which presents a polymorphism in normal Chinese samples and does not affect in vivo mitochondrial oxidative metabolism as described in a previous study. Evolutionary analysis failed to indicate any putatively pathogenic mutation that ...

2008-08-25

407

Site-specific semisynthetic variant of human hemoglobin  

International Nuclear Information System (INIS)

A single round of Edman degradation was employed to remove the NH_2-terminal valine from isolated #alpha# chains of human hemoglobin. Reconstitution of normal #beta# chains with truncated or substituted #alpha# chains was used to form truncated (des-Val"1-#alpha#1) and substituted ([[1-"1"3C]Gly"1]#alpha#1) tetrameric hemoglobin analogs. Structural homology of the analogs with untreated native hemoglobin was established by using several spectroscopic and physical methods. Functional studies indicate that the reconstituted tetrameric protein containing des-Val"1-#alpha# chains has a higher affinity for oxygen, is less influenced by chloride ions or 2,3-biphosphoglycerate, and shows lower cooperativity than native hemoglobin. These results confirm the key functional role of the #alpha#-chain NH_2 terminus in mediating cooperative oxygen binding across the dimer interface. The NH_2-terminal pK/sub 1/2/ value was determined for the ["1"3C]glycine-substituted analog to be 7.46 +/- 0.09 at ...

408

Roles of the #beta# 146 histidyl residue in the molecular basis of the Bohr Effect of hemoglobin: A proton nuclear magnetic resonance study  

International Nuclear Information System (INIS)

Assessment of the roles of the carboxyl-terminal #beta#146 histidyl residues in the alkaline Bohr effect in human and normal adult hemoglobin by high-resolution proton nuclear magnetic resonance spectroscopy requires assignment of the resonances corresponding to these residues. By a careful spectroscopic study of human normal adult hemoglobin, enzymatically prepared des(His146#beta#)-hemoglobin, and the mutant hemoglobins Cowtown (#beta#146His #-># Leu) and York (#beta#146His #-># Pro), the authors have resolved some of these conflicting results. By a close incremental variation of pH over a wide range in chloride-free 0.1 M N-(2-hydroxyethyl)piperazine-N'-2-ethanesulfonic acid buffer, a single resonance has been found to be consistently missing in the proton nuclear magnetic resonance spectra of these hemoglobin variants. The results indicate that the contribution of the #beta#146 histidyl residues is 0.52 H"+/hemoglobin tetramer at pH 7.6, markedly less ...

409

Polymorphisms in fatty acid metabolism-related genes are associated with colorectal cancer risk  

DEFF Research Database (Denmark)

Colorectal cancer is the third most common malignant tumor and the fourth-leading cause of cancer death worldwide. The crucial role of fatty acids for a number of important biological processes suggests a more in depth analysis of inter-individual differences in fatty acid metabolizing genes as contributing factor to colon carcinogenesis. We examined the association between genetic variability in 43 fatty acid metabolism-related genes and colorectal risk in 1225 CRC cases and 2032 controls participating in the European Prospective Investigation into Cancer and Nutrition study. 392 single nucleotide polymorphisms were selected using pairwise tagging with an r(2) cutoff of 0.8 and a minor allele frequency of >5%. Conditional logistic regression models were used to estimate odds ratios and corresponding 95% confidence intervals. Haplotype analysis was performed using a generalized linear model framework. On the genotype level, HPGD, PLA2G6, and TRPV3 were associated with higher risk ...

2010-01-01

410

Novel bifunctional natriuretic peptides as potential therapeutics.  

Science.gov (United States)

Synthetic atrial natriuretic peptide (carperitide) and B-type natriuretic peptide (BNP; nesiritide) are used to treat congestive heart failure. However, despite beneficial cardiac unloading properties, reductions in renal perfusion pressures limit their clinical effectiveness. Recently, CD-NP, a chimeric peptide composed of C-type natriuretic peptide (CNP) fused to the C-terminal tail of Dendroaspis natriuretic peptide (DNP), was shown to be more glomerular filtration rate-enhancing than BNP in dogs. However, the molecular basis for the increased responsiveness was not determined. Here, we show that the DNP tail has a striking effect on CNP, converting it from a non-agonist to a partial agonist of natriuretic peptide receptor (NPR)-A while maintaining the ability to activate NPR-B. This effect is specific for human receptors because CD-NP was only a slightly better activator of rat NPR-A due to the promiscuous nature of CNP in this species. Interesting, the DNP tail alone had no effect ...

2008-10-21

411

Marine transportation of oil from Timan Pechora and from inland Russian fields  

Energy Technology Data Exchange (ETDEWEB)

As part of The International Northern Sea Route Programme (INSROP), Subprogram III, Trade and Commercial Shipping, a study has been made concerning seaborne export of liquefied petroleum gas (LPG) from the Northern Russia, especially the West Siberian fields in Tyumen. The main purpose of the total project III.0703, part 2 and this study is to evaluate the economic viability of seaborne export from this area to the European region, mainly with the use of a special ice-strengthened LPG vessel, constructed and designed for such seaborne operations. This study concentrates on both seaborne LPG transportation, the demand and supply for seaborne LPG in the world and marine transportation of LPG from the West Siberian fields. Another purpose is to see which regions are potential exporters, importers and buyers of seaborne export of LPG from Tyumen. Currently large quantities of liquefied gas are flared off at the West Siberian fields due to insufficient infrastructure, lack of modern ...

1996-05-01

412

Mapping of the human cone transducin {alpha} subunit (GNAT2) gene to 1p13 and mutation analysis in patients with Stargardt`s disease  

Energy Technology Data Exchange (ETDEWEB)

Transducin {alpha} subunits are members of a large family of G-proteins and play an important role in phototransduction in rod and cone photoreceptors. We report the localization of the human cone {alpha} transducin (GNAT2) gene using fluorescence in situ hybridization (FISH) on chromosome 1 in band p13. The recent assignment of a gene for Stargardt`s disease to the same chromosomal region by linkage analysis prompted us to investigate the possible role of GNAT2 in the pathogenesis of this disease. Stargardt`s disease is characterized by degeneration in late childhood or early adulthood of the macula of the retina, a region rich in cones. We screened patients with Stargardt`s disease, with or without peripheral cone involvement as monitored by the full-field ERG, for mutations in this gene. We investigated 66 unrelated patients including 22 with peripheral cone dysfunction for mutations in the coding region of the GNAT2 gene using polymerase chain reaction-single strand conformation ...

1994-09-01

413

Influence of two changes in the composition of an acrylic bone cement on its handling, thermal, physical, and mechanical properties.  

Science.gov (United States)

This study is a contribution to the growing body of work on the influence of changes in the composition of an acrylic bone cement on various properties of the curing and cured material. The focus is on one commercially-available acrylic bone cement brand, Surgical Simplex P, and three variants of it and a series of properties, namely, setting time, maximum exotherm temperature, activation energy and frequency factor for the polymerization reaction, diffusion coefficient for the uptake of phosphate buffered saline, at 37 degrees C, ultimate compressive strength (UCS), plane-strain fracture toughness, fatigue life (under fully-reversed tension-compression stress), hardness (H) and elastic modulus (both determined using quasi-static nanoindentation), and the variation of the storage and loss moduli with frequency of the applied force in a dynamic nanoindentation test. It was found that (a) a 68% reduction in the volume of the activator, N,N dimethyl-4-toluidine, ...

2007-05-05

414

Genomic analysis of the symbiotic marine crenarchaeon, Cenarchaeumsymbiosum  

Energy Technology Data Exchange (ETDEWEB)

Crenarchaea are ubiquitous and abundant microbial constituents of soils, sediments, lakes and ocean waters, yet relatively little is known about their fundamental evolutionary, ecological, and physiological properties. To better describe the ubiquitous nonthermophilic Crenarchaea, we analyzed the genome sequence of one representative, the uncultivated sponge symbiont, Cenarchaeum symbiosum. C. symbiosum genotypes coinhabiting the same host partitioned into two dominant populations, corresponding to previously described a- and b-type ribosomal RNA variants. Although synthetic, overlapping a- and b-type ribotypes harbored significant genetic variability. A single tiling path comprising the dominant a-type genotype was assembled, and used to explore the biological properties of C. symbiosum and its planktonic relatives. Out of a total of 2,066 predicted open reading frames, 36% were more highly conserved with other Archaea. The remainder partitioned between bacteria ...

2006-06-24

415

Extracellular ATP4- promotes cation fluxes in the J774 mouse macrophage cell line  

Energy Technology Data Exchange (ETDEWEB)

Extracellular ATP stimulates transmembrane ion fluxes in the mouse macrophage cell line J774. In the presence of Mg2+, nonhydrolyzable ATP analogs and other purine and pyrimidine nucleotides do not elicit this response, suggesting the presence of a specific receptor for ATP on the macrophage plasma membrane. One candidate for such a receptor is the ecto-ATPase expressed on these cells. We, therefore, investigated the role of this enzyme in ATP-induced /sup 86/Rb+ efflux in J774 cells. The ecto-ATPase had a broad nucleotide specificity and did not hydrolyze extracellular ATP in the absence of divalent cations. /sup 86/Rb+ efflux was not blocked by inhibition of the ecto-ATPase and did not require Ca2+ or Mg2+. In fact, ATP-stimulated /sup 86/Rb+ efflux was inhibited by Mg2+ and correlated with the availability of ATP4- in the medium. In the absence of divalent cations, the slowly hydrolyzable ATP analogs adenosine 5'-(beta, gamma-imido)triphosphate (AMP-PNP) and adenosine ...

1987-03-05

416

Cost of ownership for military cargo aircraft using a common versus disparate display configuration  

Science.gov (United States)

A 2009 paper considered possibilities for applying a common display suite to various front-line bubble canopy fighters, whereas further research suggests the cost savings, post Milestone C production/deployment, might not be advantageous. The situation for military cargo and tanker aircraft, may offer a different paradigm. The primary objective of Defense acquisition is to acquire quality products that satisfy user needs with measurable improvements to mission capability and operational support, in a timely manner, and at a fair and reasonable price. DODD 5000.01 specifies that all participants in the acquisition system shall recognize the reality of fiscal constraints, viewing cost as an independent variable. DoD Components must therefore plan programs based on realistic projections of the dollars and manpower likely to be available in future years and also identify the total costs of ownership, as well as the major drivers of total ownership costs. In theory, therefore, this has ...

2010-04-01

417

Corrosion of stainless steels in 20 to 75% nitric acid. Final report. Korrosion von Chrom-Nickel-(Molybdaen)-Staehlen in unterazeotroper und azeotroper Salpetersaeure. Schlussbericht  

Energy Technology Data Exchange (ETDEWEB)

A series of stainless austenitic and ferritic materials was exposed for 100 days to boiling nitric acid which contained no corrosion products; the corrosion rates and depths of the grain boundary attack were observed. - Provided the structure is precipitation-free, the following are suitable for long-term exposure; the austenitic steels X 2 CrNi 19 11, X 1 CrNi 25 21, X 1 CrNiMoN 25 22 2 and X 1 NiCrMoCu 31 27 4, the practically Mo-free and Cu-free development steel X 1 NiCr 31 27, and the highly Mo-alloyed variant X 1 NiCrMoCu 31 27 5. - In the case of alloy NiCr21Mo it is advisable to limit the concentration and/or temperature of the nitric acid. - The 'superferrite' X 1 CrNiMoNb 28 4 2, the Japanese steel X 1 CrNiNb 30 2 and the austenitic steels X 2 CrNiMoN 17 13 3 and X 1 CrNiMoN 25 22 2 in the version with high nickel content are unsuitable. The decisive factor affecting the surface-removal rates is the chromium content of the material. The ...

1988-01-01

418

Computed tomography in the diagnosis of cavum septum pellucidum  

Energy Technology Data Exchange (ETDEWEB)

The cavum septum pellucidum is an anatomical variants of the septum pellucidum, and lying between two lateral ventricles and this is referred to as the fifth ventricle. Occasionally, posterior extension of the cavum septum pellucidum towards the splenium is seen and this is known as the cavum vergae, or sixth ventricle. The septum is double membrane and occasionally a narrow cavity containing CSF is present between these membrane. The roof of the cavum septum pellucidum is formed by the corpus callosum and its floor by the anterior pillars of the fornix. This cavum outlined with air is occasionally seen in the pneumoencephalography. Brain CT scans of 1000 patients were performed, and the diagnosis could be made on the basis of the characteristic shape, density and location. Other diagnostic procedure are not necessary in these cases. Patients were examined with CT scanner from June-80' to Dec-80', at department of radiology, Maryknoll Hospital, ...

1981-09-15

419

Comparing compressed sequences for faster nucleotide BLAST searches.  

Science.gov (United States)

Molecular biologists, geneticists, and other life scientists use the BLAST homology search package as their first step for discovery of information about unknown or poorly annotated genomic sequences. There are two main variants of BLAST: BLASTP for searching protein collections and BLASTN for nucleotide collections. Surprisingly, BLASTN has had very little attention; for example, the algorithms it uses do not follow those described in the 1997 BLAST paper and no exact description has been published. It is important that BLASTN is state-of-the-art: Nucleotide collections such as GenBank dwarf the protein collections in size, they double in size almost yearly, and they take many minutes to search on modern general purpose workstations. This paper proposes significant improvements to the BLASTN algorithms. Each of our schemes is based on compressed bytepacked formats that allow queries and collection sequences to be compared four bases at a time, permitting very fast ...

420

Comparative analysis of budded virus infectivity of Bombyx mandarina and B. mori nucleopolyhedroviruses.  

Science.gov (United States)

Bombyx mandarina nucleopolyhedrovirus (BomaNPV) is a variant of Bombyx mori nucleopolyhedrovirus (BmNPV). BomaNPV S1 strain has been reported to be significantly less virulent than the BmNPV T3 strain via the oral infection route in B. mori larvae, but other features of S1 including budded virus (BV) infectivity and virus propagation in cultured cells are still unknown. In this study, we compared BV infectivity of S1 and T3 in B. mori larvae and cultured cells. Larval bioassays by intrahemocoelic BV injection revealed that the median lethal dose of S1's BV was approximately three times lower than that of T3. In addition, S1 produced more BVs and occlusion bodies (OBs) in the hemolymph of B. mori larvae compared with T3. Furthermore, we observed that the locomotion was enhanced earlier and the median lethal time was shorter in S1-infected larvae compared with those in T3-infected larvae. Western blot analysis of S1- and T3-infected BmN cells revealed that expression ...

2011-05-22

421

#omega#-Assisted nucleation and growth of #alpha# precipitates in the Ti-5Al-5Mo-5V-3Cr-0.5Fe #beta# titanium alloy  

International Nuclear Information System (INIS)

This paper discusses the structural and compositional changes at the nanometer scale associated with the nucleation and growth of #alpha# precipitates in the #beta# titanium alloy Ti-5553 (Ti-5Al-5Mo-5 V-3Cr-0.5Fe) with #omega# precipitates acting as heterogeneous nucleation sites. The microstructural evolution in this alloy, during #beta#-solutionizing, quenching and aging type heat-treatments, has been investigated by combining results from scanning electron microscopy, orientation imaging microscopy, transmission electron microscopy, high-resolution TEM and three-dimensional atom probe (3DAP) tomography. Athermal #omega# precipitates form in this alloy on quenching from above the #beta# transus temperature. On isothermal annealing at low temperatures, these #omega# precipitates coarsen to form chemically ordered #omega# precipitates, accompanied by the nucleation of the stable #alpha# phase. Annealing at higher temperatures leads to dissolution of #omega# and further growth of ...

2009-04-01

422

Assessment of soil-gas, soil, and water contamination at the former 19th Street landfill, Fort Gordon, Georgia, 2009-2010  

Science.gov (United States)

Soil gas, soil, and water were assessed for organic and inorganic constituents at the former 19th Street landfill at Fort Gordon, Georgia, from February to September 2010. Passive soil-gas samplers were analyzed to evaluate organic constituents in the hyporheic zone and flood plain of a creek and soil gas within the estimated boundaries of the former landfill. Soil and water samples were analyzed to evaluate inorganic constituents in soil samples, and organic and inorganic constituents in the surface water of a creek adjacent to the landfill, respectively. This assessment was conducted to provide environmental constituent data to Fort Gordon pursuant to requirements of the Resource Conservation and Recovery Act Part B Hazardous Waste Permit process. The passive soil-gas samplers deployed in the water-saturated hyporheic zone and flood plain of the creek adjacent to the former landfill indicated the presence of total petroleum hydrocarbon (TPH) and octane above method ...

2011-01-01

423

Viral RNA testing and automation on the bead-based CBNE detection microsystem.  

Energy Technology Data Exchange (ETDEWEB)

We developed prototype chemistry for nucleic acid hybridization on our bead-based diagnostics platform and we established an automatable bead handling protocol capable of 50 part-per-billion (ppb) sensitivity. We are working towards a platform capable of parallel, rapid (10 minute), raw sample testing for orthogonal (in this case nucleic acid and immunoassays) identification of biological (and other) threats in a single sensor microsystem. In this LDRD we developed the nucleic acid chemistry required for nucleic acid hybridization. Our goal is to place a non-cell associated RNA virus (Bovine Viral Diarrhea, BVD) on the beads for raw sample testing. This key pre-requisite to showing orthogonality (nucleic acid measurements can be performed in parallel with immunoassay measurements). Orthogonal detection dramatically reduces false positives. We chose BVD because our collaborators (UC-Davis) can supply samples from persistently infected animals; and because ...

2008-09-01

424

Use of a point-of-care beta-hydroxybutyrate sensor for detection of ketonemia in dogs.  

Science.gov (United States)

The urine test strip is the most common test used to detect ketones in veterinary patients, but it can underestimate the degree of ketonuria and hence, ketonemia. Additionally, adequate urine samples for analysis may be difficult to obtain from dehydrated animals. The standard method used to detect and monitor ketonemia in human medicine is measurement of serum or whole blood beta-hydroxybutyrate (?HOB). A point-of-care (POC) analyzer has been validated for this purpose in humans. This study compared the accuracy of the POC device to an enzymatic reaction laboratory method for measurement of ?HOB in dogs. Although the POC sensor tended to overestimate ?HOB concentrations, there was good correlation (R(2) = 0.96) and good agreement between the 2 methods with a bias +/- precision of 0.0860 +/- 0.3410 mmol/L ?HOB. The POC ?HOB sensor can be useful for assessing ketonemia in dogs. PMID:21119867

2010-09-01

425

Use of Multiwalled Carbon Nanotubes as a SPE Adsorbent for Analysis of Carfentrazone-Ethyl in Water  

British Library Electronic Table of Contents (United Kingdom)

Solid-phase extraction and gas chromatography with electron-capture detection has been used for sensitive, simple, and reliable analysis of carfentrazone-ethyl residues in water. Carfentrazone-ethyl was enriched by use of multiwalled carbon nanotubes (MWCNT), a new adsorptive material. Several conditions affecting recovery of the analyte, for example polarity and volume of eluents, pH of water samples, and sample volume, were studied. Recovery from fortified samples, linear range, and limit of detection were evaluated. The results showed that MWCNT are an efficient SPE adsorbent for preconcentration of carfentrazone-ethyl in water. Under the optimized SPE conditions, recovery of carfentrazone-ethyl from fortified water was 81.49?91.08%, with RSD from 1.66 to 8.21%. The limits of detection ...

2009-01-01

426

The KCAL VERA 22 GHz calibrator survey  

CERN Document Server

We observed at 22 GHz with the VLBI array VERA a sample of 1536 sources with correlated flux densities brighter than 200 mJy at 8 GHz. One half of target sources has been detected. The detection limit was around 200 mJy. We derived the correlated flux densities of 877 detected sources in three ranges of projected baseline lengths. The objective of these observations was to determine the suitability of given sources as phase calibrators for dual-beam and phase-referencing observations at high frequencies. Preliminary results indicate that the number of compact extragalactic sources at 22 GHz brighter than a given correlated flux density level is twice less than at 8 GHz.

2011-01-01

427

Sorbent extraction and high performance liquid chromatography (HPLC) of homidium bromide and isometamidium chloride in bovine plasma  

International Nuclear Information System (INIS)

Homidium bromide and isometamidium chloride are used extensively in the treatment of bovine trypanosomiasis in Africa, but no specific and sensitive method to detect the drug in plasma has been published yet. Comparing the methods of other investigators it was found that they could not overcome the protein binding of these drugs which reduced the available and determined drug to 10% of the real concentrations. These techniques overcome the protein binding by enzyme digestion and an alteration of the pH before adding the sample directly on clean-up columns. Drug recover rates above 80% were obtained. For the detection, the HPLC was employed using a C18 reversed phase analytical column and UV detection, determining both drugs as intact molecules. (author).

1992-01-01

428

Solution state hybridization detection using time-resolved fluorescence anisotropy of quantum dot-DNA bioconjugates  

British Library Electronic Table of Contents (United Kingdom)

In this Letter, we demonstrate the application of time-resolved fluorescence anisotropy measurements to detect solution state hybridization of streptavidin conjugate (CdSe)ZnS quantum dots (QD). The study was performed on samples containing 10nM QD incubated with 800nM DNA. We show that the rotational correlation time of QD-DNA constructs increases significantly upon hybridization with values of 330ns (QD-ssDNA) and 1.3ms (QD-dsDNA), corresponding to a diameter of 14nm and 23nm respectively. The present study opens a new modality for hybridization detection using quantum dots.

2010-01-01

429

Recursive neural networks for processing graphs with labelled edges: theory and applications.  

Science.gov (United States)

In this paper, we introduce a new recursive neural network model able to process directed acyclic graphs with labelled edges. The model uses a state transition function which considers the edge labels and is independent both from the number and the order of the children of each node. The computational capabilities of the new recursive architecture are assessed. Moreover, in order to test the proposed architecture on a practical challenging application, the problem of object detection in images is also addressed. In fact, the localization of target objects is a preliminary step in any recognition system. The proposed technique is general and can be applied in different detection systems, since it does not exploit any a priori knowledge on the particular problem. Some experiments on face detection, carried out on scenes acquired by an indoor camera, are reported, showing very promising results. PMID:16181770

2005-09-21

430

Radiolabelled peanut lectin for the scintigraphy detection of cancer  

International Nuclear Information System (INIS)

To investigate the role of intravenously administered, radioiodinated peanut lectin ("1"3"1I-PNA) in the non-invasive detection of cancer, the pharmacokinetics and scintigraphic distribution of this novel tumor-seeking compound were studied in 8 patients with metastatic cancer of the colon, breast or lung. Scintigraphic localization of "1"3"1I-PNA was apparent at certain anatomical sites of known metastases in 2 patients and in a further 2 patients an adjacent malignant pleural effusion was visualized. The rapid clearance of radioactivity from the whole body and plasma with marked renal concentration and rapid urinary excretion of significant amounts of intact "1"3"1I-PNA (mol.wt. 107,000,pI 5.95) implied that this molecule was excreted selectively by the renal tubules. PNA or other lectins may find a role in the scintigraphic detection of selected types of cancer. (author).

1984-01-01

431

Prospects for the direct detection of the cosmic neutrino background  

Energy Technology Data Exchange (ETDEWEB)

The existence of a cosmic neutrino background - the analogue of the cosmic microwave background - is a fundamental prediction of standard big bang cosmology. Up to now, the observational evidence for its existence is rather indirect and rests entirely on cosmological observations of, e.g., the light elemental abundances, the anisotropies in the cosmic microwave background, and the large scale distribution of matter. Here, we review more direct, weak interaction based detection techniques for the cosmic neutrino background in the present epoch and in our local neighbourhood. We show that, with current technology, all proposals are still off by some orders of magnitude in sensitivity to lead to a guaranteed detection of the relic neutrinos. The most promising laboratory search, based on neutrino capture on beta decaying nuclei, may be done in future experiments designed to measure the neutrino mass through decay kinematics. (orig.)

2009-01-15

432

Programmable radionuclide X-ray fluorescence multi-channel spectrometric analyzer, type 123-1  

International Nuclear Information System (INIS)

The whole equipment consists of three separate portable parts: a detector case, a microprocessor and a graphic TV monitor. Magnetic tape memory and an x-y recorder can be connected for recording the measured spectra. The analyzer contains two built-in exchangeable excitation radionuclides. Fluorescence and scattered radiation is detected using a proportional detector. The detected pulses are analyzed by a 256-channel analyzer and the results are shown on the display. The device may be used in mining laboratories, coal and ore dressing plant control rooms or in mining fields of open cast mines for quick detection of the quality of mined or dressed raw materials. (E.S.). 1 fig.

1988-01-01

433

Position sensitive detection of individual nuclear particle scintillations using image intensifier tubes  

International Nuclear Information System (INIS)

An imaging position sensitive detector for charged particles, neutrons, X-and gamma rays has been developed. The novel feature of this scintillation imaging radiation detector is its ability to detect individual nuclear particle scintillations with a h igh degree of spatial resolution. The key elements of this detector system are a high gain, low noise image intensifier tube, a CCD camera and commercially available image processing hardware and software. This detector system is highly effective for applications such as low fluence and real time neutron radiography, mapping of radioactive contamination in nuclear reactor fuel rods, X-ray diffraction imaging, high speed autoradiography and in general position sensitive detection of nuclear radiation. Results of some of the exploratory experiments carried out using this detector system are presented in this paper. (orig.).

1996-01-01

434

PET and MRI in cardiac imaging: from validation studies to integrated applications  

International Nuclear Information System (INIS)

Positron emission tomography (PET) is the gold standard for non-invasive assessment of myocardial viability and allows accurate detection of coronary artery disease by assessment of myocardial perfusion. Magnetic resonance imaging (MRI) provides high resolution anatomical images that allow accurate evaluation of ventricular structure and function together with detection of myocardial infarction. Potential hybrid PET/MR tomography may potentially facilitate the combination of information from these imaging modalities in cardiology. Furthermore, the combination of anatomical MRI images with the high sensitivity of PET for detecting molecular targets may extent the application of these modalities to the characterization of atherosclerotic plaques and to the evaluation of angiogenetic or stem cell therapies, for example. This article reviews studies using MRI and PET in parallel to compare their performance in cardiac ...

2009-03-01

435

Onset of nucleate boiling and onset of fully developed subcooled boiling using pressure transducers signals spectral analysis  

International Nuclear Information System (INIS)

The experimental technique used for detection of subcooled boiling through analysis of the fluctuation contained in pressure transducer signals is presented. This work was partly conducted at the Institut fuer Kerntechnik und zertoerungsfreie Pruefverfahren von Hannover (IKPH, Germany) in a thermal-hydraulic circuit with one electrically heated rod with annular geometry test section. Piezo resistive pressure sensors are used for onset of nucleate boiling (ONB) and onset of fully developed boiling (OFDB) detection using spectral analysis/ signal correlation techniques. Experimental results are interpreted by phenomenological analysis of these two points and compared with existing correlation. The results allow to conclude that this technique is adequate for the detection and monitoring of the ONB and OFDB. (author)

436

Onset of nucleate boiling and onset of fully developed subcooled boiling using pressure transducers signals spectral analysis  

Energy Technology Data Exchange (ETDEWEB)

The experimental technique used for detection of subcooled boiling through analysis of the fluctuation contained in pressure transducer signals is presented. This work was partly conducted at the Institut fuer Kerntechnik und zertoerungsfreie Pruefverfahren von Hannover (IKPH, Germany) in a thermal-hydraulic circuit with one electrically heated rod with annular geometry test section. Piezo resistive pressure sensors are used for onset of nucleate boiling (ONB) and onset of fully developed boiling (OFDB) detection using spectral analysis/ signal correlation techniques. Experimental results are interpreted by phenomenological analysis of these two points and compared with existing correlation. The results allow to conclude that this technique is adequate for the detection and monitoring of the ONB and OFDB. (author)

2001-12-01

437

One-step RNA pathogen detection with reverse transcriptase activity of a mutated thermostable Thermus aquaticus DNA polymerase  

British Library Electronic Table of Contents (United Kingdom)

We describe the cloning and characterization of a mutated thermostable DNA polymerase from Thermus aquaticus (Taq) that exhibits an increased reverse transcriptase activity and is therefore designated for one-step PCR pathogen detection using established real-time detection methods. We demonstrate that this Taq polymerase mutant (Taq M1) has similar PCR sensitivity and nuclease activity as the respective Taq wild-type DNA polymerase. In addition, and in marked contrast to the wild-type, Taq M1 exhibits a significantly increased reverse transcriptase activity especially at high temperatures (>60degreeC). RNA generally hosts highly stable secondary structure motifs, such as hairpins and G-quadruplexes, which complicate, or in the worst case obviate, reverse transcription (RT). Thus, RT at hi...

2010-01-01

438

Mining User Comment Activity for Detecting Forum Spammers in YouTube  

CERN Document Server

Research shows that comment spamming (comments which are unsolicited, unrelated, abusive, hateful, commercial advertisements etc) in online discussion forums has become a common phenomenon in Web 2.0 applications and there is a strong need to counter or combat comment spamming. We present a method to automatically detect comment spammer in YouTube (largest and a popular video sharing website) forums. The proposed technique is based on mining comment activity log of a user and extracting patterns (such as time interval between subsequent comments, presence of exactly same comment across multiple unrelated videos) indicating spam behavior. We perform empirical analysis on data crawled from YouTube and demonstrate that the proposed method is effective for the task of comment spammer detection.

2011-01-01

439

Liquid chromatography with ultraviolet and dual parallel mass spectrometric detection for analysis of vitamin D in retail fortified orange juice  

British Library Electronic Table of Contents (United Kingdom)

Samples of vitamin D fortified orange juice obtained from retail food stores were analyzed for vitamin D3 content using a method developed by combining the best features of two AOAC methods. Detection by ultraviolet absorption at 265nm was compared to detection by selected ion monitoring (SIM) using atmospheric pressure chemical ionization (APCI) mass spectrometry (MS). Furthermore, an ion trap (IT) mass spectrometer was employed in a 'dual parallel MS' arrangement to simultaneously obtain qualitative APCI-ITMS data. The method was applied to 33 samples of 3 national American orange juice brands and 7 samples of 5 other American brands collected using a statistically designed sampling plan as part of the National Food and Nutrient Analysis Program to provide values for the USDA National Nu...

2011-01-01

440

Limitation of immunohistochemical localization of estrogen receptor  

Energy Technology Data Exchange (ETDEWEB)

Although the radioreceptor method is widely used for estrogen receptor assay in human tissue, it has several limitations and a number of alternative methods are being explored. An immunohistochemical method of estrogen receptor assay using a specific antibody to estradiol has been proposed as a suitable alternative. The present study was designed to evaluate the validity of this method in detecting true estrogen receptors in human tumor tissue. Using radioiodinated antibody to estrogen, we have demonstrated that the estrogen antibody can detect the estrogen when it is bound to 4S type receptor but is unable to bind to estrogen when the hormone is bound to 8S type receptor. Our observations suggest that the immunohistochemical method of detection of intracellular cytosolic receptor for estrogen is not a suitable alternative to the currently used radioreceptor method.

1986-10-01

441

Identification and staging of bladder carcinoma  

International Nuclear Information System (INIS)

The purpose of the present study was to compare the effectiveness of MRI, CT and radioimmunoscintigraphy in the staging and detection of bladder cancers in 28 patients. We distinguish two groups: Group I included the tumour stages CIS-T_3_A and the second group the deep infiltrative tumours T_3_B-T_4. MRI was slightly superior to CT in respect of tumour staging (75% correct results as compared to 63%). No understaging occurred with MRI, whereas in 22% of the cases the stage of the tumour was underestimated using CT diagnostics. Overstaging occurred in 25% of the MRI and 15% of the CT-diagnostics, respectively. RIS cannot distinguish the tumour groups, and hence this method is useful only for the detection of the primary tumour and metastases. In 77% of cases the tumour was detected and in 15% the tumour could be safely excluded. (orig.).

442

Idaho Explosives Detection System  

Energy Technology Data Exchange (ETDEWEB)

The Idaho Explosives Detection System was developed at the Idaho National Laboratory (INL) to respond to threats imposed by delivery trucks potentially carrying explosives into military bases. A full-scale prototype system has been built and is currently undergoing testing. The system consists of two racks, one on each side of a subject vehicle. Each rack includes a neutron generator and an array of NaI detectors. The two neutron generators are pulsed and synchronized. A laptop computer controls the entire system. The control software is easily operable by minimally trained staff. The system was developed to detect explosives in a medium size truck within a 5-min measurement time. System performance was successfully demonstrated with explosives at the INL in June 2004 and at Andrews Air Force Base in July 2004.

2005-12-01

443

Hybrid Camera Surveillance System Using Robust Human Detection  

Science.gov (United States)

We propose a novel surveillance system that uses hybrid camera network. The system contains a panorama camera and PTZ cameras to take the wide range images and face images at high enough resolution for identification tasks. The robust human detection methods include robust background subtraction method (RRC), skin color segmentation and face tracking method. First, the system detects persons from a panorama image, and then the detailed face images are obtained with the PTZ cameras. The PTZ cameras can track the faces using the four directional features and the relaxation matching. In addition, the system has automatic camera position calibration feature. Thus, the user can use the system without any troublesome settings.

2007-01-01

444

Graphene-Pt nanocomposite for nonenzymatic detection of hydrogen peroxide with enhanced sensitivity  

British Library Electronic Table of Contents (United Kingdom)

A sensitive hydrogen peroxide (H2O2) sensor was fabricated based on graphene-Pt (GN-Pt) nanocomposite. The GN-Pt was synthesized by photochemical reduction of K2PtCl4 on GNs, and characterized by atomic force microscope (AFM), transmission electron microscope (TEM), and energy-dispersive X-ray spectroscopy (EDS). Electrochemical investigations indicated that the GN-Pt exhibited a high peak current and low overpotential towards the reduction of H2O2. The GN-Pt modified glass carbon electrode displayed a wide linear range (2-710mM), low limit of detection (0.5mM) and good selectivity for detection of H2O2 with a much higher sensitivity than that of Pt nanoparticles or graphene modified electrode.

2011-01-01

445

Final report: technical contributions to the development of incipient fault detection/location instrumentation  

Energy Technology Data Exchange (ETDEWEB)

The transmission of electrical energy by use of underground cables is increasing. Fault location techniques have certain limitations; incipient fault detection and location would help reduce the maintenance cost of these lines as well as improve the reliability of service. The report discusses some test results related to RF-probing techniques applied to high-voltage transmission lines. The high-frequency losses and attenuation in high-voltage cables places certain ultimate limitations on RF-probing techniques for incipient fault detection. Time-domain reflectrometry methods were employed to assess the RF-transmission properties of high-voltage cables at frequencies as high as 6 GHz. Fast-Fourier-transform deconvolution was used to obtain loss measurements as a function of frequency. The loss mechanisms were identified. The measurement hardware and methods are discussed as well as analysis approach leading to the conclusions.

1986-04-01

446

Fault detection and diagnosis of a gearbox in marine propulsion systems using bispectrum analysis and artificial neural networks  

British Library Electronic Table of Contents (United Kingdom)

A marine propulsion system is a very complicated system composed of many mechanical components. As a result, the vibration signal of a gearbox in the system is strongly coupled with the vibration signatures of other components including a diesel engine and main shaft. It is therefore imperative to assess the coupling effect on diagnostic reliability in the process of gear fault diagnosis. For this reason, a fault detection and diagnosis method based on bispectrum analysis and artificial neural networks (ANNs) was proposed for the gearbox with consideration given to the impact of the other components in marine propulsion systems. To monitor the gear conditions, the bispectrum analysis was first employed to detect gear faults. The amplitude-frequency plots containing gear characteristic sign...

2011-01-01

447

False discovery rate: setting the probability of false claim of detection  

CERN Document Server

When testing multiple hypothesis in a survey --e.g. many different source locations, template waveforms, and so on-- the final result consists in a set of confidence intervals, each one at a desired confidence level. But the probability that at least one of these intervals does not cover the true value increases with the number of trials. With a sufficiently large array of confidence intervals, one can be sure that at least one is missing the true value. In particular, the probability of false claim of detection becomes not negligible. In order to compensate for this, one should increase the confidence level, at the price of a reduced detection power. False discovery rate control is a relatively new statistical procedure that bounds the number of mistakes made when performing multiple hypothesis tests. We shall review this method, discussing exercise applications to the field of gravitational wave surveys.

2005-01-01

448

Ergosterol analyses of oil palm seedlings and plants infected with Ganoderma  

British Library Electronic Table of Contents (United Kingdom)

Basal stem rot of oil palm (OP) by Ganoderma boninense is of major economic concern and it is the predominant disease of OP in SE Asia. Also, other plantation crops are affected by Ganoderma. The early detection of symptoms is crucial for control, although effective methods remain elusive. Ergosterol is the principal sterol of fungi and plays an essential role in the cell membrane and other cellular constituents. The analysis of ergosterol is useful for fungal detection in solid plant substrates. The present report compares ergosterol concentration in sound and decayed OP seedlings and mature plants using HPLC with diode array detection. The disease of OP requires to be considered as a white rot process where fungal biomass will increase from a low to high level as the infection progresses...

2011-01-01

449

Electrochemical noise in corrosion  

International Nuclear Information System (INIS)

By varying different variables (potential, chloride content, surface pretreatment etc.) it is possible to show the effect of increasingly harsher corrosion conditions on passive-layer stability. These changes will not be detected by conventional methods e.g. measurement of passive current density, until a very late stage. Electrochemical noise measurement will allow the action of inhibitors to be detected in a rapid and effective manner. High-alloy steels and titanium claddings subjected to pitting corrosion in chloride-containing media demonstrate how to use this method for problem solutions and to open up new practical applications. The effect of mechanical stresses (natural, tensile) on the corrosion system can be detected by electrochemical noise which opens up new methods for crack corrosion studying and monitoring. (orig./DG).

1993-10-07

450

Direct detection of Salmonella without pre-enrichment in milk, ice-cream and fruit juice by PCR against hilA gene  

British Library Electronic Table of Contents (United Kingdom)

A novel PCR based assay was devised to specifically detect contamination of any Salmonella serovar in milk, fruit juice and ice-cream without pre-enrichment. This method utilizes primers against hilA gene which is conserved in all Salmonella serovars and absent from the close relatives of Salmonella. An optimized protocol, in terms time and money, is provided for the reduction of PCR contaminants from milk, ice-cream and juice through the use of routine laboratory chemicals. The simplicity, efficiency (time taken 3-4 h) and sensitivity (to about 5-10 CFU/ml) of this technique confers a unique advantage over other previously used time consuming detection techniques. This technique does not involve pre-enrichment of the samples or extensive sample processing, which was a pre-requisite in mos...

2012-01-01

451

Diagnostic and Prognostic Utility of t(14;18) in Follicular Lymphoma  

British Library Electronic Table of Contents (United Kingdom)

Abstract Background: Follicular lymphoma (FL) is one of the most common non-Hodgkin's lymphomas of B cells, being closely associated with a t(14;18) translocation. Detection of t(14;18), which is present in 70-95% of FL, might aid in FL diagnosis. Objective: To compare the efficacy of routine polymerase chain reaction (PCR) and fluorescence in situ hybridization (FISH) techniques in detecting t(14;18) in paraffin-embedded tissue samples of FL patients at different stages. Combined with other immunophenotypic biological determinants, detection of t(14;18) might help to determine patients at increased risk according to the FL International Prognostic Index (FLIPI) and therefore facilitate appropriate treatment. Design and Methods: This study was mainly based on a retrospective examination of...

2007-01-01

452

Development of SDT sensor based eddy current probe for detection of deep fatigue cracks in multi-layer structure  

British Library Electronic Table of Contents (United Kingdom)

The detection and characterization of deeply buried fatigue damage in thick, multi-layer airframe components pose significant technical challenges to the aviation safety community. Currently, no nondestructive evaluation technique is available to reliably detect such potential damage from the exterior of the airframe, which is highly desirable in light of inspection cost as well as avoidance of structure damage. Recent technological advances in high-sensitivity magnetic sensors, i.e., spin-dependent tunneling (SDT) sensors, make it feasible to employ electromagnetic inspection techniques for deep fatigue crack inspection. In this work, we report on the development and fabrication of a low frequency eddy current probe based on a magnetically shielded SDT pickup sensor concentrically located...

2010-01-01

453

Determination of low-molecular-weight organic acids and inorganic anions by gradient elution chromatography  

Energy Technology Data Exchange (ETDEWEB)

Conditions of the separation and detection of organic and inorganic anions by gradient ion chromatography and suppressed conductivity detection were studied, and the procedure of gradient elution was optimized. A detection limit of 1 x 10{sup -3} {mu}g x L{sup -1} was obtained using the pre-concentrated column and most relative standard deviations obtained in the determination of seven organic and inorganic anions were below 5%. This method was proved to be simple, rapid and accurate for the separation and determination of low-molecular-weight organic acids and inorganic anions and could be applied in the analysis of the samples from water and steam systems of thermal power plants with satisfactory results. (orig.)

2007-03-15

454

Detection of explosives in traces by laser induced breakdown spectroscopy: Differences from organic interferents and conditions for a correct classification  

British Library Electronic Table of Contents (United Kingdom)

With the aim to study and to improve LIBS capability for detecting residues of energetic compounds in air surrounding, nine types of explosives and some potential interferents, placed in small quantities on a metallic support, were interrogated by a laser. Shot-to-shot behavior of the line intensities relative to the sample constituents was studied. The detected plasma was not stoichiometric and the line intensities, as well as their ratios, were changing even for an order of magnitude from one sampling point to another, particularly in the case of aromatic compounds. We explained some sources of such LIBS signal's behavior and this allowed us to establish a data processing procedure, which leads to a good linearization among the data sets. In this way, it was possible to determine some re...

2011-01-01

455

Detection of Free-Living Amoebae in Some Water Sources and its Control by Ultraviolet- Radiation  

International Nuclear Information System (INIS)

Among the numerous free-living amoebae (FLA) of soil and water habitats, certain species belonging to two genera Acanthamoeba and Naegleria are facultative parasites of man.They cause disease called primary amoebic meningoencephalitis where history of contact with water was recorded in most of the cases especially with Naegleria species. The present work aimed to search for presence of free-living amoebae in the water and trials for its control by Ultraviolet-radiation (UV-radiation). Samples from different water sources were examined for the presence of free-living amoebae. These samples were cultured on non-nutrient agar streaked with bacteria. Amoebae were detected and identified by means of their morphological characters. Twelve positive cases of one hundred and twenty examined samples could be detected. The positive samples were exposed to different doses of UV-radiation for different times.

456

Detecting hot spots at hazardous-waste sites  

Energy Technology Data Exchange (ETDEWEB)

Evaluating the need for remedial cleanup at a waste site involves both finding the average contaminant concentration and identifying highly contaminated areas, or hot spots. A nomographic procedure to determine the sample configuration needed to locate a hot spot is presented. The technique can be used to develop a waste-site sampling plant - to determine either the grid spacing required to detect a hot spot at a given level of confidence, or the probability of finding a hot spot of a certain size, given a particular grid spacing. The method and computer program (ELIPGRID) were developed for locating geologic deposits, but the basic procedure can also be used to detect hot spots at chemical- or nuclear-waste disposal sites. Nomographs based on the original program are presented for three sampling-grid configurations - square, rectangular and triangular.

1984-07-09

457

Contrast material extravasation following upper abdominal trauma. Detection with helical Computerized Tomography  

International Nuclear Information System (INIS)

Active contrast material extravasation can be recognized with conventional CT scanners, though it has been considered a rare finding. Helical CT seems to increase the detection rate and especially to boost the radiologist's confidence in this diagnosis. Though active bleeding is defined in severely-injured subjects requiring urgent intervention and may be associated with findings of hypovolaemic shock, it should not be considered itself as a negative prognostic factor. Contrast extravasation is due to ongoing hemorrhage and its detection is critical for urged treatment. Accurate anatomical location permits to choose surgical management or transcatheter embolization and thus decreases time consumption for precis e bleeding site identification.

1999-03-01

458

Analysis of Ground Deformation Detected Using the SBAS-DInSAR Technique in Umbria, Central Italy  

British Library Electronic Table of Contents (United Kingdom)

Ground deformation affecting the Umbria region (central Italy) in the 9-year period from 1992 to 2000 was investigated through multi-temporal Differential Synthetic Aperture Radar Interferometry (DInSAR). For the purpose, the Small BAseline Subset (SBAS) technique was adopted, which allows studying the temporal evolution of the detected deformation at two spatial scales: a low-resolution (regional) scale, and a full-resolution (local) scale. For the analysis, SAR data acquired by the European Remote Sensing (ERS-1/2) satellites along ascending and descending orbits were used. The detected deformation was analysed to investigate its relevance to geophysical, geomorphologic, and human-induced processes that may result in hazardous conditions to the population of Umbria. Low-resolution deform...

2009-01-01

459

An effective method to estimate multidimensional Gaussian states  

CERN Document Server

A simple and efficient method for characterization of multidimensional Gaussian states is suggested and experimentally demonstrated. Our scheme shows analogies with tomography of finite dimensional quantum states, with the covariance matrix playing the role of the density matrix and homodyne detection providing Stern-Gerlach-like projections. The major difference stems from a different character of relevant noises: while the statistics of Stern-Gerlach-like measurements is governed by binomial statistics, the detection of quadrature variances correspond to chi-square statistics. For Gaussian and near Gaussian states the suggested method provides, compared to standard tomography techniques, more stable and reliable reconstructions. In addition, by putting together reconstruction methods for Gaussian and arbitrary states, we obtain a tool to detect the non-Gaussian character of optical signals.

2009-01-01

460

Advanced conceptual design report: T Plant secondary containment and leak detection upgrades. Project W-259  

Energy Technology Data Exchange (ETDEWEB)

The T Plant facilities in the 200-West Area of the Hanford site were constructed in the early 1940s to produce nuclear materials in support of national defense activities. T Plant includes the 271-T facility, the 221-T facility, and several support facilities (eg, 2706-T), utilities, and tanks/piping systems. T Plant has been recommended as the primary interim decontamination facility for the Hanford site. Project W-259 will provide capital upgrades to the T Plant facilities to comply with Federal and State of Washington environmental regulations for secondary containment and leak detection. This document provides an advanced conceptual design concept that complies with functional requirements for the T Plant Secondary Containment and Leak Detection upgrades.

1995-05-12

461

A shallow subsurface controlled release facility in Bozeman, Montana, USA, for testing near surface CO2 detection techniques and transport models  

Energy Technology Data Exchange (ETDEWEB)

A controlled field pilot has been developed in Bozeman, Montana, USA, to study near surface CO2 transport and detection technologies. A slotted horizontal well divided into six zones was installed in the shallow subsurface. The scale and CO2 release rates were chosen to be relevant to developing monitoring strategies for geological carbon storage. The field site was characterized before injection, and CO2 transport and concentrations in saturated soil and the vadose zone were modeled. Controlled releases of CO2 from the horizontal well were performed in the summers of 2007 and 2008, and collaborators from six national labs, three universities, and the U.S. Geological Survey investigated movement of CO2 through the soil, water, plants, and air with a wide range of near surface detection techniques. An overview of these results will be presented.

2009-10-20

462

A Comprehensive Survey of Data Mining-based Fraud Detection Research  

CERN Document Server

This survey paper categorises, compares, and summarises from almost all published technical and review articles in automated fraud detection within the last 10 years. It defines the professional fraudster, formalises the main types and subtypes of known fraud, and presents the nature of data evidence collected within affected industries. Within the business context of mining the data to achieve higher cost savings, this research presents methods and techniques together with their problems. Compared to all related reviews on fraud detection, this survey covers much more technical articles and is the only one, to the best of our knowledge, which proposes alternative data and solutions from related domains.

2010-01-01

463

Use of a questionnaire to obtain an alcohol history from those attending an inner city accident and emergency department.  

UK PubMed Central (United Kingdom)

A screening questionnaire designed to take an alcohol history was used on 996 patients attending the London Hospital Accident and Emergency Department. Questions concerned with 'binge' drinking detected...Full Text Available

1989-03-01

464

The effects of high voltage transmission lines on the health of adjacent resident populations.  

UK PubMed Central (United Kingdom)

A community health survey of 438 individuals was taken to detect health problems related to high voltage electrical transmission among an adjacent residential population. Results revealed no significant...Full Text Available

1984-01-01

465

Synthesis and characterization of a biotinylated organophosphorus ester for detection and affinity purification of a brain serine esterase: neuropathy target esterase.  

UK PubMed Central (United Kingdom)

We have synthesized a novel stable precursor, saligenin phosphorotrichloridate, which, on reaction with N-monobiotinyldiamines, generates a series of biotinylated covalent inhibitors of serine esterases....Full Text Available

1994-07-15

466

Sodium leak detector  

International Nuclear Information System (INIS)

Purpose: To permit accurate detection of sodium leakage by distinguishing between variations in the overflow tank level due to changes in sodium temperature accompanying changes in the power level or operating state of a liquid metal sodium cooled fast breeder, and a reduction in power level due to duct leakage. Constitution: The volume of sodium in the primary cooling system is roughly estimated from the temperatures of hot and cold legs, and the duct leak preset level with respect to the sodium liquid level within an overflow tank when the plant is normal is varied according to the state of the plant. More particularly, the volume of sodium within the overflow tank is calculated on the basis of a signal representing the liquid level detected by a liquid level gauge in the overflow tank and a signal representing the temperature detected by hot leg and cold leg thermometers, thereby obtaining the preset value of the liquid ...

467

Sequential Molecular and Cellular Events during Neoplastic Progression: A Mouse Syngeneic Ovarian Cancer Model1  

UK PubMed Central (United Kingdom)

AbstractStudies performed to identify early events of ovarian cancer and to establish molecular markers to support early detection and development of chemopreventive regimens have been...Full Text Available

2005-10-01

468

Sequence space coverage, entropy of genomes and the potential to detect non-human DNA in human samples  

UK PubMed Central (United Kingdom)

BackgroundGenomes store information for building and maintaining organisms. Complete sequencing of many genomes provides the opportunity to study and compare global information properties...Full Text Available

469

Separate Non-Homomorphic Checking Codes for Binary Addition.  

Science.gov (United States)

In this paper, necessary and sufficient conditions for successful detection of errors in a binary adder by any separate code are developed. The author demonstrates the existence of separate checking codes for addition modulo (2 sup n) ( n > or = 4) and mo...

1972-01-01

470

Sensitive detection of endocrine disrupters using ionic liquid - Single walled carbon nanotubes modified screen-printed based biosensors.  

Science.gov (United States)

Simple and low cost biosensor based on screen-printed electrode for sensitive detection of some alkylphenols was developed, by entrapment of HRP in a nanocomposite gel based on single-walled carbon nanotubes (SWCNTs) and 1-butyl-3-methylimidazolium hexafluorophosphate ([BMIM][PF(6)]) ionic liquid. Raman and FTIR spectroscopy, CV and EIS studies demonstrate the interaction between SWCNTs and ionic liquid. The nanocomposite gel, SWCNT-[BMIM][PF(6)] provides to the modified sensor a considerable enhanced electrocatalytic activity toward hydrogen peroxide reduction. The HRP based biosensor exhibits high sensitivity and good stability, allowing a detection of the alkylphenols at an applied potential of -0.2V vs. Ag/AgCl, in linear range from 5.5 to 97.7?M for 4-t-octylphenol and respectively, between 5.5 and 140?M for 4-n-nonylphenol, with a response time of about 5s. The detection limit was 1.1?M for 4-t-octylphenol, and ...

2011-07-19

471

Scheme for Entangling Two Distant Cavity Mirrors  

International Nuclear Information System (INIS)

A scheme is presented for the generation of entangled states for two cavity mirrors. In the scheme each mirror initially in a vacuum state interacts with a weak coherent field, resulting in a photon-number dependent kick. The detection of a photon leaking from the cavities collapses the two mirrors to an entangled state.

2008-04-15

472

Real World Evaluation of Dual-Zone ICD and CRT-D Programming Compared to Single-Zone Programming: The ALTITUDE REDUCES Study  

British Library Electronic Table of Contents (United Kingdom)

Tachycardia Detection, ICD, CRT-D Devices, Appropriate and Inappropriate Shock.-Introduction: We evaluated the frequency of appropriate and inappropriate shocks and survival in patients using dual-zone programming versus single-zone programming. Methods and Results: For the ALTITUDE REDUCES study, patients were followed for 1.6 1.1 years. The 12-month incidence of any shock was lower for dual-versus single-zone programmed detection at rates -170 bpm and between 170-200 bpm (P < 0.001). Appropriate shock rates at 1 year were also lower with dual-zone programming in these rate intervals (single zone 9.1%, 5.4%, P < 0.001, dual zone 6.7%, 4.7%, P < 0.02). There were no detectable differences between single- and dual-zone shock incidence at detection rates - 200 bpm (P = 0.14). Inappropriate s...

2011-01-01

473

Rapid technique of DNA-DNA in situ hybridisation on formalin fixed tissue sections using microwave irradiation.  

UK PubMed Central (United Kingdom)

The relative sensitivities of different protocols for detecting cytomegalovirus nucleic acid sequences in histological specimens, using a biotinylated cDNA probe, were assessed. Several commonly used...Full Text Available

1987-08-01

474

Preliminary studies on the detection of irradiated prawns using 2-alkylcyclobutanones  

Energy Technology Data Exchange (ETDEWEB)

The use of ionising radiation for the preservation of food has been under investigation for many years but has yet to receive worldwide acceptance. Although irradiation can be carefully controlled, it is generally accepted that the development of a test or tests for the detection of irradiated food would enhance consumer confidence and might help to enforce labelling regulations. The 2-alkylcyclobutanones are reported to be the only cyclic compounds formed as the products of the radiolysis of saturated and unsaturated triglycerides. The synthesis of 2-dodecylcyclobutanone (DCB) and 2-tetradecylcyclobutanone (TCB), which are formed from palmitic and stearic acid respectively following irradiation, has been carried out and using irradiated chicken meat as the model for a high-lipid containing food, both cyclobutanones have been extracted with hexane and then identified using gas chromatography/mass spectrometry (GC/MS). DCB and TCB have been ...

1996-12-31

475

Novel Human Erythrovirus Associated with Transient Aplastic Anemia  

UK PubMed Central (United Kingdom)

Erythrovirus (formerly parvovirus) B19 causes a wide range of diseases in humans, including anemia due to aplastic crisis. Diagnosis of B19 infection relies on serology and the detection of viral DNA...Full Text Available

1999-08-01

476

NAME=\\  

Wastenet

...because it had greatly contributed to the geospatial capability of coalition forces in the Global War on Terrorism by producing a system that provides high-resolution imagery for use in detecting ground changes, creating detailed maps and obtaining Intelligence, Surveillance and Reconnaissance (ISR) information. ...

477

Multiplexed, rapid detection of H5N1 using a PCR-free nanoparticle-based genomic microarray assay  

UK PubMed Central (United Kingdom)

BackgroundFor more than a decade there has been increasing interest in the use of nanotechnology and microarray platforms for diagnostic applications. In this report, we describe...Full Text Available

478

Large plasmids of fast-growing rhizobia: homology studies and location of structural nitrogen fixation (nif) genes.  

UK PubMed Central (United Kingdom)

A single large plasmid was isolated from multiplasmid-harboring strains Rhizobium leguminosarum 1001 and R. trifolii 5. These single plasmids, as well as the largest plasmid detectable in R. phaseoli...Full Text Available

1981-03-01

479

In vitro analysis of nuclear mRNA export using molecular beacons for target detection  

UK PubMed Central (United Kingdom)

A detailed molecular characterization of nuclear mRNA export will require an in vitro system, allowing a biochemical reconstitution of transport. To this end, an mRNA export assay has...Full Text Available

2003-06-01

480

Genetic Diversity in Blastomyces dermatitidis: Implications for PCR Detection in Clinical and Environmental Samples  

UK PubMed Central (United Kingdom)

SummaryBlastomycosis is a serious and potentially fatal infection by the thermally dimorphic fungus Blastomyces dermatitidis. PCR assays targeting the BAD-1 virulence...Full Text Available

2010-03-01

481

Generation and control of sound bullets with a nonlinear acoustic lens  

UK PubMed Central (United Kingdom)

Acoustic lenses are employed in a variety of applications, from biomedical imaging and surgery to defense systems and damage detection in materials. Focused acoustic signals, for example, enable ultrasonic...Full Text Available

2010-04-20

482

Gene-gene and gene-environment interactions: new insights into the prevention, detection and management of coronary artery disease  

UK PubMed Central (United Kingdom)

Despite the recent success of genome-wide association studies (GWASs) in identifying loci consistently associated with coronary artery disease (CAD), a large proportion of the genetic components of...Full Text Available

483

Fetal ascites: an unusual presentation of Niemann-Pick disease type C.  

UK PubMed Central (United Kingdom)

Two infants were seen with severe ascites detected before birth, a previously unreported presentation of Niemann-Pick disease type C. In the second infant no diagnostic storage cells were present in...Full Text Available

1989-10-01

484

Evaluation of the Hip: History and Physical Examination  

UK PubMed Central (United Kingdom)

Examination of a painful hip is fairly concise and reliable at detecting the presence of a hip joint problem. Hip joint disorders often go undetected, leading to the development of secondary disorders....Full Text Available

2007-11-01

485

Detection of trypanosomes in small ruminants and pigs in western Kenya: important reservoirs in the epidemiology of sleeping sickness?  

UK PubMed Central (United Kingdom)

BackgroundTrypanosomosis is a major impediment to livestock farming in sub-Saharan Africa and limits the full potential of agricultural development in the 36 countries where it is...Full Text Available

487

Decreased CSF Transferrin in sCJD: A Potential Pre-Mortem Diagnostic Test for Prion Disorders  

UK PubMed Central (United Kingdom)

Sporadic Creutzfeldt-Jakob-disease (sCJD) is a fatal neurodegenerative condition that escapes detection until autopsy. Recently, brain iron dyshomeostasis accompanied by increased transferrin (Tf) was...Full Text Available

488

Data Privacy, Emergency Response, Weather Prediction to Benefit from Information Technology Advances  

Science.gov (United States)

... gov Data Privacy, Emergency Response, Weather Prediction to Benefit from Information Technology ... detection, simulation and prediction of high-impact local weather, such as thunderstorms and ...

489

Cryptic invasion by a non-native genotype of the common reed, Phragmites australis, into North America  

UK PubMed Central (United Kingdom)

Cryptic invasions are a largely unrecognized type of biological invasion that lead to underestimation of the total numbers and impacts of invaders because of the difficulty in detecting them. The distribution...Full Text Available

2002-02-19

490

Comparative experimental study of dual energy subtraction and conventional digital radiography on chest  

International Nuclear Information System (INIS)

Objective: To compare the efficiency of dual energy subtraction and conventional direct digital radiography in signal detecting ability. Methods: 200 plastic balls which were 4 mm in diameter were taken as signals and were placed on a 10 cm thick plastic board and the right upper thorax of a healthy volunteer. The signals were examined by DES and CDR separately and were estimated by 3 radiologists with 5-value-differentiation method. ROC curve analysis was made by ROC kit software. Results: when signals on plastic board were detected by CDR and DES, ROC curve analysis indicated that there was no significant difference (P=0.4851 > 0.05, two-tailed) between the area under the ROC curves of the two methods (Az=0.9931 for CDR and Az=0.9879 for DES). The difference was significant (P=0.0002 <0.01, two-tailed) between the area under the ROC curves of CDR and DES (Az=0.7276 for CDR and Az=0.8561 for DES), when the signals on the right upper ...

2005-06-01

491

Cognitive performance in relapsing remitting multiple sclerosis: A longitudinal study in daily practice using a brief computerized cognitive battery  

UK PubMed Central (United Kingdom)

BackgroundThere is need for a cognitive test battery that can be easily used in clinical practice to detect or monitor cognitive performance in patients with multiple sclerosis (MS)....Full Text Available

492

Cluster analysis of behavioural and event-related potentials during a contingent negative variation paradigm in remitting-relapsing and benign forms of multiple sclerosis  

UK PubMed Central (United Kingdom)

BackgroundEvent-related potentials (ERPs) may be used as a highly sensitive way of detecting subtle degrees of cognitive dysfunction. On the other hand, impairment of cognitive skills...Full Text Available

493

Clinical significance of Fas and FasL protein expression in gastric carcinoma and local lymph node tissues  

UK PubMed Central (United Kingdom)

AIM: To investigate the relation of Fas and Fas ligand (FasL) protein expression with carcinogenesis and metastasis of gastric carcinoma.METHODS: Immunohistochemistry was used to detect Fas and...Full Text Available

2010-03-14

494

Boundary conditions for the paleoenvironment: chemical and physical processes in the pre-solar nebula  

Energy Technology Data Exchange (ETDEWEB)

Two additional hyperfine components of the interstellar radical C3H were detected. In addition, methanol was discovered in interstellar clouds. The abundance of HCCN and various chemical isomers in molecular clouds was investigated.

1985-02-01

495

Biotin-labeled hairpin oligonucleotides: probes to detect double-strand breaks in DNA in apoptotic cells.  

UK PubMed Central (United Kingdom)

Hairpin oligonucleotides were synthesized with stems ending in a double-stranded structure, which can be ligated to double-strand breaks in DNA, and with loops that contain nucleotides modified by the...Full Text Available

1998-04-01

496

Binary compact object coalescence rates: The role of elliptical galaxies  

CERN Document Server

We estimate binary compact object merger detection rates for LIGO, including the binaries formed in ellipticals long ago. Specifically, we convolve hundreds of model realizations of elliptical- and spiral-galaxy population syntheses with a model for elliptical- and spiral-galaxy star formation history as a function of redshift. Our results favor local merger rate densities of 4\\times 10^{-3} {Mpc}^{-3}{Myr}^{-1} for binary black holes (BH), 3\\times 10^{-2} {Mpc}^{-3}{Myr}^{-1} for binary neutron stars (NS), and 10^{-2} {Mpc}^{-3}{Myr}^{-1} for BH-NS binaries. Mergers in elliptical galaxies are a significant fraction of our total estimate for BH-BH and BH-NS detection rates; NS-NS detection rates are dominated by the contribution from spiral galaxies. Using only models that reproduce current observations of Galactic NS-NS binaries, we find slightly higher rates for NS-NS and largely similar ranges for BH-NS and BH-BH ...

2009-01-01

497

Analysis of Quantitative Interactions between Two Species of Arbuscular Mycorrhizal Fungi, Glomus mosseae and G. intraradices, by Real-Time PCR  

UK PubMed Central (United Kingdom)

Arbuscular mycorrhizal fungi (AMF) are obligate biotrophs, known to play an important role in ecological processes. Conventional light microscopy is the most common method used to detect their presence...Full Text Available

2006-06-01

498

An excess of rare genetic variation in ABCE1 among Yorubans and African-American individuals with HIV-1  

UK PubMed Central (United Kingdom)

Signatures of natural selection occur throughout the human genome and can be detected at the sequence level. We have re-sequenced ABCE1, a host candidate gene essential for...Full Text Available

2009-12-01

499

Advances in the detection of neutrinoless double beta decay  

British Library Electronic Table of Contents (United Kingdom)

This paper introduces briefly neutrinoless Double Beta Decay and discusses its implications for neutrino physics. After a presentation of general experimental concepts, such as the various proposed methodological approaches and the sensitivity, the current experimental situation is concisely reviewed.

2011-01-01

500

A multistep bioinformatic approach detects putative regulatory elements in gene promoters  

UK PubMed Central (United Kingdom)

BackgroundSearching for approximate patterns in large promoter sequences frequently produces an exceedingly high numbers of results. Our aim was to exploit biological knowledge for...Full Text Available