variable viral clearance: Topics by WorldWideScience.org

Serological testing-An alternative to boosters?

The diagnosis of viral causes of many infectious diseases is difficult due to the inherent sequence diversity of viruses as well as the ongoing emergence of novel viral pathogens, such as SARS coronavirus...Full Text Available

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British Library Electronic Table of Contents (United Kingdom)

The issue of the duration of immunity, particularly for the modified live viral components of veterinary vaccines, has been a significant part of the recent vaccination debate. One manufacturer has increased the recommended booster interval for these components to 3 years give name and another now states `up to 4 years' immunity.There remain many unanswered questions regarding this duration of immunity (DOI). Studies suitable for data sheet claims are time consuming and costly and can only be performed in laboratory dogs under tightly controlled conditions. Evidence from rabies serology testing in the UK shows that the response of individual animals to routine vaccination is highly variable. Much of the published field evidence on the persistence of antibody titres originates from North Am...

2006-01-01

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Specific Residues of the Influenza A Virus Hemagglutinin Viral RNA Are Important for Efficient Packaging into Budding Virions?

Involvement of the Matrix and Nucleocapsid Domains of the Bovine Leukemia Virus Gag Polyprotein Precursor in Viral RNA Packaging

A final step in the influenza virus replication cycle is the assembly of the viral structural proteins and the packaging of the eight segments of viral RNA (vRNA) into a fully infectious virion. The...Full Text Available

2007-09-01

5

Defective hepatitis B virus particles are generated by packaging and reverse transcription of spliced viral RNAs in vivo.

The RNA packaging process for retroviruses involves a recognition event of the genome-length viral RNA by the viral Gag polyprotein precursor (PrGag), an important step in particle morphogenesis. The...Full Text Available

2003-09-01

6

Human viral gastroenteritis.

Generation of replicative defective viruses is frequently observed during viral infections. We now report that encapsidation and reverse transcription of spliced viral RNA is an additional mechanism...Full Text Available

1991-10-01

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Comparison of a multivalent viral vaccine program versus a univalent viral vaccine program on animal health, feedlot performance, and carcass characteristics of feedlot calves

During the last 15 years, several different groups of fastidious viruses that are responsible for a large proportion of acute viral gastroenteritis cases have been discovered by the electron microscopic...Full Text Available

1989-01-01

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I-131 labelled peanut lectin renal kinetics in cis-platin induced tubular toxicity in dogs

A field study was conducted under commercial feedlot conditions at 2 sites in western Canada to determine the relative effects of a univalent viral vaccine (MLV 1) program versus a multivalent viral...Full Text Available

2003-01-01

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Functional expression of anti-hepatitis B virus (HBV) preS2 antigen scFv by cspA promoter system in Escherichia coli and application as a recognition molecule for single-walled carbon nanotube (SWNT) field effect transistor (FET)

Quantitative I-131 labelled Peanut lectin (I-131-PNA) renal clearance was determined in dogs before and after a 5 day single cycle cis-platinum chemotherapy regimen (0.5mg/Kg/day). Results were statistically compared with E.R.P.F. (I-131-Hippuran), G.F.R. (Tc-99m-DTPA), and serum biochemistry and correlated with histopathology. I-131-PNA clearance was significantly reduced in all dogs 5 days after cessation of cis-platinum treatment (mean #DELTA#S% = 71.3%) and similar reductions in the gamma camera derived renogram peak were demonstrated (mean #DELTA#S% = 65.8%). E.R.P.F. was noted to drop by a minor degree (mean #DELTA#S% = 20.9%) post treatment. G.F.R. was diminished (mean #DELTA#S% = 46.6%) and serum creatinine elevated (mean #DELTA#S% = 42.7%) in all dogs compared to their pretreatment values. Histopathology demonstrated variable degrees of tubular toxicity ranging from mild to severe. The degree of change of the ...

1985-06-02

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British Library Electronic Table of Contents (United Kingdom)

The preS2 antigens of hepatitis B virus (HBV), which causes a serious health problem in the world, have been implicated in hepatocyte cell binding and viral penetration. Therefore, the importance of antibody production against preS2 antigen for early diagnosis of HBV has been well established. In this study, the recombinant HBV preS2 single chain variable fragment (scFv) antibody was successfully expressed in E. coli with the novel cold shock vector (pCold) under the cspA promoter, and its expression level was compared with the pET vector under the T7 promoter. Additionally, a host with an oxidizing cytoplasm, E. coli trxB/gor double mutant, was used to improve the soluble expression. The anti-HBV preS2 scFv using pCold vector was successfully expressed in a soluble and functional form in ...

2010-01-01

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Metabolic clearance of biologically active luteinizing hormone in man.

Impact of the 3,6,9-Trioxadecyloxy Group on Desazadesferrithiocin Analogue Iron Clearance and Organ Distribution

The plasma metabolic clearance of biologically active luteinizing hormone (bioactive LH) was studied using the rat interstitial cell testosterone (RICT) bioassay in six hypogonadotropic men after single...Full Text Available

1986-04-01

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Effective In Vitro Clearance of Porphyromonas gingivalis by Fc? Receptor I (CD89) on Gingival Crevicular Neutrophils

The impact of introducing a 3,6,9-trioxadecyloxyl group at various positions of the desazadesferrithiocin (DADFT) aromatic ring on iron clearance and organ distribution is described. Three DADFT...Full Text Available

2007-07-12

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Shielding of Sleeping Beauty DNA Transposon-delivered Transgene Cassettes by Heterologous Insulators in Early Embryonal Cells

Porphyromonas gingivalis has been implicated as a causative pathogen in periodontitis. Immunotherapeutic approaches have recently been suggested to aid in the clearance of P....Full Text Available

2001-05-01

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Efficacy and safety of livwin (polyherbal formulation) in patients with acute viral hepatitis: A randomized double-blind placebo-controlled clinical trial

The Sleeping Beauty (SB) transposon system represents an important alternative to viral integrating vector systems but may, as its viral counterparts, be subject to transcriptional silencing. To investigate...Full Text Available

2009-01-01

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Antagonist HIV-1 Gag Peptides Induce Structural Changes in HLA B8

Objectives:The study was planned to evaluate the efficacy and safety of Livwin (polyherbal formulation) in acute viral hepatitis.Materials...Full Text Available

2010-10-01

16

A Strong Case for Viral Genetic Factors in HIV Virulence

In the cellular immune response, recognition by CTL-TCRs of viral antigens presented as peptides by HLA class I molecules, triggers destruction of the virally infected cell (Townsend, A.R.M., J. Rothbard,...Full Text Available

1996-12-01

17

Tracer studies with carrier-free lead-203

HIV infections show great variation in the rate of progression to disease, and the role of viral genetic factors in this variation had remained poorly characterized until recently. Now a series of four...Full Text Available

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Modeling of instabilities induced by cage clearances in ball bearings

... blood cells in vitro in vivo injection intake lead 203 man renal clearance uptake

1972-07-30

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Effects of Pentobarbital Anesthesia on Survival, 'Escherichia ...

Generalized dynamic motion of balls and cage in a ball bearing are simulated by solving the differential equations of motion under prescribed operating conditions and bearing geometry. The general cage motion is parametrically evaluated as a function of clearances both in the ball pockets and at the guide lands. The design significance of the modeling approach is demonstrated by the prediction of critical clearances which trigger certain instabilities in the cage motion. In more practical terms, the correlation between cage clearances and instability defines a wear life for the bearing under the prescribed operating conditions. 10 refs.

1991-01-01

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[HBsAG in feces, urine and saliva].

... Title : Effects of Pentobarbital Anesthesia on Survival, 'Escherichia coli' Clearance, Glucose and Leukocyte Concentration in Dogs Subjected to ...

1978-08-28

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Inhibition of melanoma growth by subcutaneous administration of hTERTC27 viral cocktail in C57BL/6 mice.

After some observations about the tests of the research exposed in the literature, authors illustrate the tests for 142 patients divided into 5 groups: a) patients affected with acute viral hepatitis; b) patients affected with praegressa acute viral hepatitis; c) relatives of patients with acute viral hepatitis; d) volunteers; e) patients affected with chronic uraemia under dialisis periodic treatment. After the testing control, authors, conclude with an hipotesis: a possible epidemic function of faeces, urine saliva, in the passage of the acute viral hepatitis. PMID:488577

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The root cause analysis of 9DVN002ZV fan failure in Daya Bay Nuclear Power Station

PMID:20856939

2010-09-13

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Progress in development of controlled-clearance pressure balance in NMIJ

Extensive investigations and detailed analysis of the failure reason of 9DVN002ZV fan in Daya Bay Nuclear Power Station showed that the fan destroy was caused by the failure of non-drive end bear. The direct cause of this bearing' failure was its improper assembly caused by improper maintenance procedure, and the root cause was too small internal radial clearance after mounting. The factor affecting bearing internal radial clearance, the relationship between clearance and operating life time and fan failure process were discussed. (authors)

2005-09-01

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Interference Effects In A Photonic Crystal Cavity

A new controlled-clearance pressure balance is under development with the aim of improving the hydraulic high-pressure standard up to 1 GPa. This pressure balance consists of three parts: (i) a pressure generation device up to 1 GPa, (ii) a weight-loading unit which can load/unload weights automatically and independently, (iii) a controlled-clearance piston-cylinder which is designed to allow the jacket pressure to be applied independently. Some adjustments were made for loading heavy weights on/off the piston safely, keeping them in balance, then generating the pressure stably. Stability of the generated pressure was checked for several piston-cylinders, and it was found that pressure fluctuation was less than a few parts per million. The jacket pressure coefficient of a 500 MPa controlled-clearance piston-cylinder was precisely evaluated as a function of both the system pressure and the jacket pressure.

2010-03-01

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Exclusion, exemption and clearance in the mining and minerals industry - A review of the concepts from a South African perspective

... AFRL-RV-PS-TP-2010-1001 9. SPONSORING / MONITORING AGENCY NAME(S) AND ADDRESS(ES) 10. ... (Clearance #377 ABW-2009-1628) 13. ...

2010-01-20

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Correlation between particle size, in vivo particle persistence, and lung injury.

The risks from mining and processing of ores is reviewed on a generic basis with particular reference to some of the confusions which can arise due to lack of consistency or common logic in the use of exclusion, exemption and clearance. The difference in exclusion and exemption are challenged by comparing doses received in high background radiation areas and the doses received from a mining practice. The common principle of risk to the human species is not applied consistently. The differences between IAEA recommendations and local regulatory conditions are compared, and the use of exemption levels as clearance levels is considered. A case study on management of mine tailings is presented with special focus on the use of clearance levels. In all areas of review the interpretation of regulation is subject to confusion resulting from inconsistencies which can distort free market economics. (author).

1997-05-06

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Carbohydrate-specified endocytosis: localization of ligand in the lysosomal compartment.

Dosimetry parameters such as deposition, clearance, retention, and translocation and dissolution of inhaled particles in and to different lung compartments may be important for the persistence of particles...Full Text Available

1994-10-01

28

Viruses and thyroiditis: an update

Carbohydrate-directed endocytosis is mediated by a receptor, the hepatic binding protein; it is responsible for the clearance of galactose-terminated glycoproteins from the circulation. This process...Full Text Available

1981-11-01

29

Picornavirus Subversion of the Autophagy Pathway

Viral infections are frequently cited as a major environmental factor involved in subacute thyroiditis and autoimmune thyroid diseases This review examines the data related to the role of viruses in...Full Text Available

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Isoprinosine augmentation of phytohemagglutinin-induced lymphocyte proliferation.

While autophagy has been shown to act as an anti-viral defense, the Picornaviridae avoid and, in many cases, subvert this pathway to promote their own replication. Evidence indicates...Full Text Available

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Adoptive immunotherapy with virus-specific T cells

The need for agents designed to modify immune response in the treatment of patients with viral infection, immunodeficiency, or cancer prompted the present study on the mechanisms of action of isoprinosine,...Full Text Available

1976-02-01

32

British Library Electronic Table of Contents (United Kingdom)

Viral infections are still common causes of morbidity and mortality in immunosuppressed patients after allogeneic hematopoietic stem cell transplantation. Infections caused by virus such as cytomegalovirus, adenovirus and Epstein-Barr virus are well-known. In addition, several other viruses such as polyomavirus and human herpesvirus 6 have been recently reported to be causes of significant complications. As the delay in recovery of virus-specific cellular immune response after transplant is associated with viral reactivation and viral disease, adoptive immunotherapy to restore virus-specific cellular immunity is an attractive option. Recent clinical trials showed the safety and effectiveness of adoptive immunotherapy against viral diseases. In this review, we summarize the current status o...

2011-01-01

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A Transposon and Transposase System for Human Application

A Novel Multi-Antigen Virally Vectored Vaccine against Mycobacterium avium Subspecies paratuberculosis

The stable introduction of therapeutic transgenes into human cells can be accomplished using viral and nonviral approaches. Transduction with clinical-grade recombinant viruses offers the potential...Full Text Available

2010-04-01

34

Effects of Pentobarbital Anesthesia on Survival, 'Escherichia coli' Clearance, Glucose and Leukocyte Concentration in Dogs Subjected to LD100. 'Escherichia coli'.

BackgroundMycobacterium avium subspecies paratuberculosis causes systemic infection and chronic intestinal inflammation in many species including...Full Text Available

35

Characteristics of boiling transition of tight lattice rod assembly

This study was conducted to determine the effects of sodium pentobarbital anesthesia on survival of the dog, leukocyte response, E. coli clearance from the peripheral blood and blood glucose concentration in the leukocytotic endotoxin pre-injected canine ...

1978-01-01

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Viral suppression of multiple escape mutants by de novo CD8⁺T cell responses in a human immunodeficiency virus-1 Infected elite suppressor

Critical power characteristics of tight lattice rod assembly was investigated using a simple-shaped experimental apparatus. An electrically heated rod with four spacers was placed in a circular tube, and boiling transition condition for a rod in an annular geometry was clarified varing annulus clearance. It was found that critical heat flux depends strongly on the clearance accoding as the gap becomes smaller. This results was compared with KfK correlation and the trends were well correlated. (author).

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Evolutionary Constraints Acting on DDX3X Protein Potentially Interferes with Rev-Mediated Nuclear Export of HIV-1 RNA

Elite suppressors or controllers (ES) are HIV-1 infected patients who maintain undetectable viral loads without treatment. While HLA-B*57-positive ES are usually infected with virus that is unmutated...Full Text Available

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Ebola Virus VP40-Induced Particle Formation and Association with the Lipid Bilayer

Differential host-pathogen interactions direct viral replication in infected cells. In HIV-1 infected cells, nuclear export of viral RNA transcripts into cellular cytoplasm is governed by interaction...Full Text Available

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Biodegradable Tri-Block Copolymer Poly(lactic acid)-poly(ethylene glycol)-poly(l-lysine)(PLA-PEG-PLL) as a Non-Viral Vector to Enhance Gene Transfection

Viral protein 40 (VP40) of Ebola virus appears equivalent to matrix proteins of other viruses, yet little is known about its role in the viral life cycle. To elucidate the functions of VP40, we investigated...Full Text Available

2001-06-01

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Scintiscanning with aerosols of "9"9Tc"m DTPA in the diagnostic strategy for pneumocystosis in aids patients

Low cytotoxicity and high gene transfection efficiency are critical issues in designing current non-viral gene delivery vectors. The purpose of the present work was to synthesize the novel biodegradable...Full Text Available

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Quantitation of infectious myonecrosis virus in different tissues of naturally infected Pacific white shrimp, Litopenaeus vannamei, using real-time PCR with SYBR Green chemistry

Pulmonary clearance of an aerosol of "9"9Tc"m DTPA was measured in 21 non-smoking AIDS and pneumocystosis patients. The results were compared with those of pulmonary scintiscanning with gallium. All the patients exhibited increased clearance, evidence of a considerable alteration in alveolar permeability. This increase was also observed in patients with normal chest X-rays and normal blood gases. The average clearance in these patients was 6 #+-# 2% min"-"1 as compared with a normal 1.1 #+-# 0.3% min"-"1. Conversely, only four out of eight patients with normal chest X-rays had abnormal gallium scans. Clearance returned to normal after recovery. Measurement of DTPA clearance appears to be a very sensitive indicator for the detection and follow-up of pneumocystosis. However, it is not very specific since it can be increased by tobacco poisoning, drug abuse and the presence of ...

1988-08-15

42

British Library Electronic Table of Contents (United Kingdom)

The Pacific white shrimp, Litopenaeus vannamei, is the most important shrimp species in volume in world aquaculture. However, in recent decades, outbreaks of diseases, especially viral diseases, have led to significant economic losses, threatening the sustainability of shrimp farming worldwide. In 2004, Brazilian shrimp farming was seriously affected by a new disease caused by the Infectious myonecrosis virus (IMNV). Thus, disease control based on rapid and sensitive pathogen detection methods has become a priority. In this study, a specific quantitation method for IMNV was developed using real-time PCR with SYBR Green chemistry and viral load of the principal target tissues of chronically infected animals was quantified. The quantitative analysis revealed that mean viral load ranged from ...

2011-01-01

43

Opportunistic esophagitis in AIDS: Radiographic diagnosis

Safety assessment for clearance of radioactive metal wastes from nuclear facility

Between 1983 and 1986, 35 of 90 patients with acquired immunodeficiency syndrome (AIDS) had double-contrast esophagograms to rule out opportunistic esophagitis. The radiographs were reviewed without knowledge of the clinical or endoscopic findings. Candida esophagitis was diagnosed radiographically in 17 patients who had varying degrees of plaque formation and viral esophagitis in three who had discrete ulcers without plaques. All three patients with viral esophagitis (herpes in 2 and cytomegalo virus in one) and 15 of 17 with Candida esophagitis had endoscopic and/or clinical corroboration of the radiographic diagnosis. Thus, the authors' experience suggests that fungal and viral esophagitis can often be differentiated on double-contrast esophagography, so that appropriate antifungal or antiviral therapy can be instituted without need for endoscopic intervention.

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Safety assessment for clearance of radioactive metal wastes from nuclear facility

Safety assessments for clearance of H-beam and valves, main radioactive metal wastes in Kori nuclear power plants, were carried out to derivate a decontamination factor for satisfying the dose limits of clearance level (Maximum individual dose: 10 {mu}Sv/y, collective dose: 1 man{center_dot}Sv/y) in Korea. Maximum individual dose and collective dose were evaluated by internal dose conversion factor which based on the concept of effective dose in ICRP publication 60. The results of maximum individual dose and collective dose is 139 {mu}Sv per year and 0.166 man{center_dot}Sv per year about H-beam, and 158 {mu}Sv per year and 0.468 man{center_dot}Sv per year about valves respectively. Demand decontamination factor satisfied with, which is respectively more than 13.9 and 15.8 for satisfying clearance level.

2003-10-01

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Pretreatment with the gram-positive bacterial cell wall molecule peptidoglycan improves bacterial clearance and decreases inflammation and mortality in mice challenged with Pseudomonas aeruginosa

Safety assessments for clearance of H-beam and valves, main radioactive metal wastes in Kori nuclear power plants, were carried out to derivate a decontamination factor for satisfying the dose limits of clearance level (Maximum individual dose: 10 #mu#Sv/y, collective dose: 1 man#centre dot#Sv/y) in Korea. Maximum individual dose and collective dose were evaluated by internal dose conversion factor which based on the concept of effective dose in ICRP publication 60. The results of maximum individual dose and collective dose is 139 #mu#Sv per year and 0.166 man#centre dot#Sv per year about H-beam, and 158 #mu#Sv per year and 0.468 man#centre dot#Sv per year about valves respectively. Demand decontamination factor satisfied with, which is respectively more than 13.9 and 15.8 for satisfying clearance level.

2003-10-01

46

Paracetamol reduces influenza-induced immunopathology in a mouse model of infection without compromising virus clearance or the generation of protective immunity

The objective of this study was to determine if inflammatory tolerance and enhancement of innate immune function could be induced by the gram-positive cell wall component peptidoglycan (PGN)....Full Text Available

2008-10-01

47

Measuring the efficacy of anti-malarial drugs in vivo: quantitative PCR measurement of parasite clearance

BackgroundSeasonal influenza A infection affects a significant cohort of the global population annually, resulting in considerable morbidity and mortality. Therapeutic strategies...Full Text Available

2011-05-01

48

Induction of cytochrome P450 1A by cow milk-based formula: a comparative study between human milk and formula

BackgroundArtemisinin-based combination therapy, currently considered the therapy of choice for uncomplicated Plasmodium falciparum malaria in endemic countries,...Full Text Available

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Dosing Recommendations for Continuous Venovenous Hemodiafiltration with AN69 Filter Membranes and Prismaflex Dialyzers

During the treatment of neonatal apnea, formula-fed infants, compared to breastfed infants, show nearly three-fold increase in clearance of caffeine, a substrate...Full Text Available

2005-09-01

50

Dissociation from albumin: a potentially rate-limiting step in the clearance of substances by the liver.

Background:Continuous renal replacement therapy is used to manage fluid and solute imbalances in critically ill patients but may affect the clearance of concurrently administered...Full Text Available

2009-11-01

51

Conservative management of post traumatic thoraco diaphragmatico biliary fistula

The hepatic uptake rate for certain albumin-bound drugs and metabolites correlates poorly with their equilibrium unbound concentration in the plasma, suggesting that binding equilibrium may not always...Full Text Available

1985-03-01

52

A neurodegenerative disease mutation that accelerates the clearance of apoptotic cells

We report herein a case of thoraco diaphragmatico biliary fistula in a 24-year-old male who was managed conservatively with antibiotics and tube thoracostomy and had complete radiological clearance.

2010-10-01

53

A Master Conductor for Aggregate Clearance by Autophagy

Frontotemporal lobar degeneration is a progressive neurodegenerative syndrome that is the second most common cause of early-onset dementia. Mutations in the progranulin gene are a major cause of familial...Full Text Available

2011-03-15

54

Translation Elongation Factor 1A Facilitates the Assembly of the Tombusvirus Replicase and Stimulates Minus-Strand Synthesis

Autophagic adapters including p62/SQSTM1 recognize polyubiquitinated autophagic targets such as toxic protein aggregates. Recently reporting in Molecular Cell, Filimonenko et al. provide evidence...Full Text Available

2010-05-18

55

Transcriptional mapping of the 3' end of the bovine syncytial virus genome.

Replication of plus-strand RNA viruses depends on host factors that are recruited into viral replicase complexes. Previous studies showed that eukaryotic translation elongation factor (eEF1A) is one...Full Text Available

2010-11-01

56

The protective antigens of equine herpesvirus type 1.

The bovine syncytial virus, a member of the retroviral subfamily Spumavirinae, causes a persistent, asymptomatic infection in cattle. Nucleotide sequence analysis of the viral genome revealed two overlapping...Full Text Available

1994-02-01

57

The Viral Replication Complex Is Associated with the Virulence of Newcastle Disease Virus?

Equine herpesvirus type 1 was cultivated in swine testis cell cultures and partially purified by differential centrifugation and centrifugation in a linear sucrose density gradient. The viral envelope...Full Text Available

1978-04-01

58

Structural Basis for Acetylated Histone H4 Recognition by the Human BRD2 Bromodomain*

Virulent strains of Newcastle disease virus ([NDV] also known as avian paramyxovirus type 1) can be discriminated from low-virulence strains by the presence of multiple basic amino acid residues at...Full Text Available

2010-10-01

59

Solid-Phase Radioimmunoassay of Total and Influenza-Specific Immunoglobulin G

Recognition of acetylated chromatin by the bromodomains and extra-terminal domain (BET) family proteins is a hallmark for transcriptional activation and anchoring viral genomes to mitotic chromosomes...Full Text Available

2010-03-05

60

Shellfish depuration by gamma irradiation: Final report for the period October 1, 1985-September 30, 1986

An antigen-antibody system of polystyrene tubes coated with immunoglobulin antibody was used for quantitating immunoglobulins. A similar radioimmunoassay method was adapted for a viral antigen-antibody...Full Text Available

1972-02-01

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Selective Degradation of Newly Synthesized Nonmessenger Simian Virus 40 Transcripts

Irradiation of live bivalve molluscs is a promising new technique to reduce the public health threats of viral and bacterial pathogens in the consumption of raw shellfish. In studies conducted within the past year, live hardshelled clams and oysters were innoculated with Simian Rotavirus SA-11, Poliovirus I, and Hepatitis-A virus and treated with gamma ray ionizing radiation from University of Lowell/DOE 800,000 Curie "6"0Co source over a dose range of 0.5--10 kiloGray (50--1000 kilorad) to determine the effectiveness of the process in eliminating viral activity and thus easing the potential viral health threats associated with uncooked bivalves. Two viral strains, SA-11 and Poliovirus I, were employed as models to perfect laboratory technique and to estimate the most appropriate range of dose exposures necessary for optimal inactivation of the infectious pathogen, Hepatitis A. Post-irradiation ...

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Selection of Inhibitor-Resistant Viral Potassium Channels Identifies a Selectivity Filter Site that Affects Barium and Amantadine Block

By pretreating simian virus 40-infected BSC-1 cells with glucosamine, [³H]uridine labeling of both cellular and viral RNA can be halted instantaneously by addition of cold uridine. We have...Full Text Available

1978-11-01

63

Production of Infectious Genotype 1b Virus Particles in Cell Culture and Impairment by Replication Enhancing Mutations

BackgroundUnderstanding the interactions between ion channels and blockers remains an important goal that has implications for delineating the basic mechanisms of ion channel function...Full Text Available

64

PREVALENCE OF MYCOPLASMA AGASSIZII AND CHELONIAN HERPESVIRUS IN CAPTIVE TORTOISES (TESTUDO SP.) IN THE UNITED KINGDOM

With the advent of subgenomic hepatitis C virus (HCV) replicons, studies of the intracellular steps of the viral replication cycle became possible. These RNAs are capable of self-amplification in cultured...Full Text Available

2009-06-01

65

Only Slight Impact of Predicted Replicative Capacity for Therapy Response Prediction

... the tropism of both mycoplasmas and herpesviruses for epithelial tissue still indicate oral swabs to be the most ... feces.18 Alphaherpesviruses show a marked tropism for epithelial tissue, with viral rep...

66

Nucleocapsid and Matrix Protein Contributions to Selective Human Immunodeficiency Virus Type 1 Genomic RNA Packaging

BackgroundReplication capacity (RC) of specific HIV isolates is occasionally blamed for unexpected treatment responses. However, the role of viral RC in response to antiretroviral...Full Text Available

67

Novel Human Erythrovirus Associated with Transient Aplastic Anemia

The nucleocapsid protein (NC) of retroviruses plays a major role in genomic RNA packaging, and some evidence has implicated the matrix protein (MA) of certain retroviruses in viral RNA binding. To further...Full Text Available

1998-03-01

68

Mutational Analysis of cis-Acting RNA Signals in Segment 7 of Influenza A Virus?

Erythrovirus (formerly parvovirus) B19 causes a wide range of diseases in humans, including anemia due to aplastic crisis. Diagnosis of B19 infection relies on serology and the detection of viral DNA...Full Text Available

1999-08-01

69

Multiple integration sites for Moloney murine leukemia virus in productively infected mouse fibroblasts.

The genomic viral RNA (vRNA) segments of influenza A virus contain specific packaging signals at their termini that overlap the coding regions. To further characterize cis-acting signals...Full Text Available

2008-12-01

70

Move or Die: the Fate of the Tax Oncoprotein of HTLV-1

The integration sites for viral DNA in cells infected with Moloney murine leukemia virus (M-MuLV) were studied by restriction endonuclease cleavage of cellular DNA followed by electrophoresis in agarose...Full Text Available

1979-06-01

71

Mechanism of Host Defense Suppression Induced by Viral Infection: Mode of Action of Inosiplex as an Antiviral Agent

The HTLV-1 Tax protein both activates viral replication and is involved in HTLV-1-mediated transformation of T lymphocytes. The transforming properties of Tax include altering the expression of select...Full Text Available

72

Lentiviral vector-mediated stable expression of sTNFR-Fc in human macrophage and neuronal cells as a potential therapy for neuroAIDS

The mechanism of influenza virus (INFV)-induced immunosuppression and the mode of inosiplex action against INFV infection were studied. INFV suppressed both anti-lipopolysaccharide and anti-sheep erythrocyte...Full Text Available

1982-10-01

73

Intracellular ribonucleoprotein complexes of visna virus are infectious.

BackgroundHuman immunodeficiency virus type 1 (HIV-1) infection frequently causes neurologic disease, which is the result of viral replication and activation of macrophages and microglia...Full Text Available

74

Infection of Dendritic Cells by a ?2-Herpesvirus Induces Functional Modulation1

Sheep choroid plexus cells infected with visna virus produce intracytoplasmic viral ribonucleoprotein complexes with sedimentation values of 120S to 200S and buoyant densities of 1.29 to 1.32 g/cm3....Full Text Available

1982-06-01

75

In vitro dimerization of human immunodeficiency virus type 1 (HIV-1) spliced RNAs

The murine γ-herpesvirus-68 (γHV68) establishes viral latency in dendritic cells (DCs). In the present study, we examined the specific consequences...Full Text Available

2005-09-01

76

Human Immunodeficiency Virus type-1 reverse transcriptase exists as post-translationally modified forms in virions and cells

The human immunodeficiency virus type 1 (HIV-1) packages its genomic RNA as a dimer of homologous RNA molecules that has to be selected among a multitude of cellular and viral RNAs. Interestingly, spliced...Full Text Available

2007-12-01

77

Host-Encoded Reporters for the Detection and Purification of Multiple Enveloped Viruses

BackgroundHIV-1 reverse transcriptase (RT) is a heterodimer composed of p66 and p51 subunits and is responsible for reverse transcription of the viral RNA genome into DNA. RT can...Full Text Available

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HPV16 E2 could act as down-regulator in cellular genes implicated in apoptosis, proliferation and cell differentiation

The identification of host cell factors for virus replication holds great promise for the development of new anti-viral therapies. Recently, high-throughput screening methods have emerged as...Full Text Available

2010-08-01

79

Flucytosine for treatment of Candida albicans in H1N1-positive patient

BackgroundHuman Papillomavirus (HPV) E2 plays several important roles in the viral cycle, including the transcriptional regulation of the oncogenes E6 and E7, the regulation of the...Full Text Available

80

Epigallocatechin gallate inhibits HBV DNA synthesis in a viral replication - inducible cell line

A 17-year-old H1N1-positive patient was successfully extubated after 25 days of ventilatory support for treatment of viral pneumonia which was complicated by empyema thoracis due to Candida...Full Text Available

2010-10-01

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Differential recognition of viral RNA by RIG-I

AIM: To analyze the antiviral mechanism of Epigallocatechin gallate (EGCG) against hepatitis B virus (HBV) replication.METHODS: In this research, the HBV-replicating cell line HepG2.117 was used...Full Text Available

2011-03-21

82

Dengue virus-specific murine T-lymphocyte proliferation: serotype specificity and response to recombinant viral proteins.

Retinoic acid inducible gene I (RIG-I) is a pattern recognition receptor (PRR) responsible for detection of nucleic acids from pathogens in the cytoplasm of infected cells and induction of type I interferon...Full Text Available

2011-03-01

83

Dengue Fever in Humanized NOD/SCID Mice

Definition of the T-lymphocyte responses to dengue viruses should aid in the development of safe and effective vaccines and help to explain the pathophysiology of dengue hemorrhagic fever and dengue...Full Text Available

1989-06-01

84

De Novo Induction of Genetically Engineered Brain Tumors In Mice Using Plasmid DNA

The increased transmission and geographic spread of dengue fever (DF) and its more severe presentation, dengue hemorrhagic fever (DHF), make it the most important mosquito-borne viral disease of humans...Full Text Available

2005-11-01

85

Consequences of unlocking the cardiac myosin molecule in human myocarditis and cardiomyopathies

Spontaneous mouse models of cancer show promise to more accurately recapitulate human disease and predict clinical efficacy. Transgenic mice or viral vectors have been required to generate spontaneous...Full Text Available

2009-01-15

86

Comparative analysis of differentially expressed genes in normal and white spot syndrome virus infected Penaeus monodon

Myocarditis, often initiated by viral infection, may progress to autoimmune inflammatory heart disease, dilated cardiomyopathy and heart failure. Although cardiac myosin is a dominant autoantigen...Full Text Available

2008-09-01

87

Clostridium difficile is not associated with outbreaks of viral gastroenteritis in the elderly in the Netherlands

BackgroundWhite spot syndrome (WSS) is a viral disease that affects most of the commercially important shrimps and causes serious economic losses to the shrimp farming industry worldwide....Full Text Available

88

Chromosomal sites for hepatitis B virus integration in human hepatocellular carcinoma.

The coincidental increase in norovirus outbreaks and Clostridium difficile infection (CDI) raised the question of whether these events could be related, e.g. by enhancing spread by...Full Text Available

2010-06-01

89

Challenge and Hope in Radiotherapy of Hepatocellular Carcinoma

The discovery that hepatitis B virus (HBV) integrates into host chromosomes raises the question of whether such viral DNA integration correlates directly with the activation of specific oncogenes or...Full Text Available

1991-12-01

90

Bacterial Artificial Chromosome Mutagenesis Using Recombineering

Hepatocellular carcinoma (HCC) is one of the most critical global health issues. With frequent association of viral liver disease, HCC is highly complex, harboring both cancer and chronic liver disease....Full Text Available

2009-10-31

91

Autoantibodies to BRAF, a new family of autoantibodies associated with rheumatoid arthritis

Gene expression from bacterial artificial chromosome (BAC) clones has been demonstrated to facilitate physiologically relevant levels compared to viral and nonviral cDNA vectors. BACs are large enough...Full Text Available

2011-01-01

92

Antibody protects against lethal infection with the neurally spreading reovirus type 3 (Dearing).

IntroductionBRAF (v raf murine sarcoma viral oncogene homologue B1) is a serine-threonine kinase involved in the mitogen-activated protein kinase (MAPK) signalling pathway, known...Full Text Available

2010-01-01

93

Activation of Cytotoxic and Regulatory Functions of NK Cells by Sindbis Viral Vectors

The mammalian reoviruses have provided a valuable model for studying the pathogenesis of viral infections of the central nervous system (CNS). We have used this model to study the effect of antibody...Full Text Available

1988-12-01

94

Ab binding alters gene expression in Cryptococcus neoformans and directly modulates fungal metabolism

Oncolytic viruses (OVs) represent a relatively novel anti-cancer modality. Like other new cancer treatments, effective OV therapy will likely require combination with conventional treatments. In order...Full Text Available

95

A viral vaccine encoding PSA induces antigen spreading to a common set of self proteins in prostate cancer patients

Abs facilitate humoral immunity via the classical mechanisms of opsonization, complement activation, Ab-dependent cellular cytotoxicity, and toxin/viral neutralization. There is also evidence that some...Full Text Available

2010-04-01

96

A rapid and efficient method for region- and strand-specific mutagenesis of cloned DNA.

PurposeWe previously reported a randomized phase II clinical trial combining a poxvirus-based vaccine encoding PSA with radiotherapy in patients with localized prostate...Full Text Available

2010-08-01

97

Patterns of blood pressure variability in normotensive and hypertensive rats.

The single-stranded viral DNA of an M13 phage recombinant containing the early promoter region of SV40 was hybridized with linear, double-stranded replicative form DNA of a related M13 phage containing...Full Text Available

1982-01-01

98

DEFF Research Database (Denmark)

Udgivelsesdato: 1995-Nov

1995-01-01

99

Interactions in multiple schedules: negative induction with squirrel monkeys1

Velocity measurement of wake behind flat plate simulating BWR fuel spacer

In Experiment I, lever pressing by squirrel monkeys was maintained under a sequence of variable-interval, multiple variable-interval variable-interval, and multiple variable-interval extinction schedules...Full Text Available

1978-11-01

100

Radiostrontium clearance and bone formation in response to simulated internal screw fixation

Velocity field behind a flat plate, placed near the wall in a narrow channel as a simulant of a BWR fuel spacer, was measured by using a hot wire anemometer. It was found that not only the positions where the dead water region behind flat plate disappeared but also the locations where the velocity relaxation completed were almost independent of the width of the clearance, although the local average velocity and velocity fluctuation immediately downstream the flat plate were affected by the difference in the clearance. The transverse flow diversions in the channel cross section were evaluated from the shape of the average velocity profile. The decrease of local flow rate near the channel wall, which may causes the drift flow behind a flat plate, was encouraged as the drag of clearance increased. Attempts have been made to measure spanwise velocity in the narrow channel. A spanwise velocity that occurred due to flow diversion ...

2004-10-04

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101

Mechanisms of renal handling of lead

Changes in radiostrontium clearance (SrC) and bone formation (tetracycline labeling) were observed in the femurs of skeletally mature dogs following the various operative steps involved in bone screw fixation. Drilling, but not periosteal stripping, produced a small but statistically significant increase in SrC and endosteal bone formation in the distal third of the bone. Strontium clearance values equivalent to those produced by drilling alone were recorded after screw fixation at low or high torque (5 versus 20 inch pounds), as well as by the insertion of loosely fitting stainless steel implants. Bone formation (equals the percentage tetracycline-labeled trabecular bone surfaces) was increased by 30% when SrC values exceeded 3.5 ml/100 g bone/min, and the relationship was linear when SrC values ranged between 1.0 and 7.0 ml/100 g bone/min. The changes in SrC and bone formation one-week after bone screw application are primarily those ...

1987-06-01

102

Measurement of swirling flow in direct injection diesel engine (Part 2). Effect of piston cavity diameter and top clearance volume

The relative roles of glomerular filtration, tubular reabsorption and tubular secretion in lead handling were evaluated using renal clearance technique, stop-flow analysis, and renal lead accumulation. In addition, the effect of altering acid-base status on renal handling of Pb was determined. Clearance of ultrafilterable lead was measured in anesthetized dogs during infusion of "2"0"3Pb with small doses of carrier Pb(0.5 to 50 #mu#g/kg/h). Filterable lead concentration was estimated by in vitro ultrafiltration of non-anticoagulated plasma. Fractional excretion of Pb was calculated using creatinine clearance to estimate glomerular filtration rate. Dogs in acute metabolic acidosis had the lowest fractional excretion of ultrafilterable Pb (< 0.1); those in alkalosis had high fractional Pb excretion (0.75 to 2.5) while normal dogs were intermediate (0.1 to .4). The fractional excretion of Pb during metabolic alkalosis ...

103

Hemoglobin radiolabeling: in vitro and in vivo comparison of iodine labeling with iodogen and a new method for technetium labeling

Swirling flow in a direct injection diesel engine was measured by a laser doppler velocimeter. Piston cavity diameter and top clearance volume were changed as factors affecting swirling flow to study the distribution of swirling flow speed. When using the same intake port and changing the opening ratio of piston cavity, the distribution of swirling flow speed was different by the cavity during intake process but these agree just after opening intake valve and then become again different by cavity. When increasing top clearance and decreasing compression ratio, the axial symmetry of flow during commpression process increases. When changing piston cavity, and also when changing intake port, the mean swirling ratio in inside and outside areas of combustion chamber has common tendency to increase and decrease respectively. The mean swirling flow in the combustion chamber may be capable to be predicted by devising a model which can describe this ...

1989-05-31

104

Variable elimination in chemical reaction networks with mass action kinetics

The present investigation compares the suitability of two radiolabeling techniques for hemoglobin. "1"2"5I labeling of hemoglobin with Iodogen as iodinating agent caused major changes in the chromatographic behaviour and an accelerated plasma clearance of the labeled hemoglobin in rats. A recently developed two-step procedure for "9"9"mTc labeling gave better results. The label had only minimal influence on the chromatographic behaviour of hemoglobin. In vivo, no free label occurred in the circulation and no transfer of the label to other plasma proteins took place. The plasma clearance of "9"9"mTc-labeled hemoglobin in rats was slowed. However, this could be explained entirely by diminishing glomerular filtration, probably by inhibition of the dissociation of the hemoglobin molecule into dimers. The plasma clearance of hemoglobin modified by intramolecular cross-linking, which prevents dissociation of the molecule into ...

105

Absorption of lead from the bronchial region of the lung

We consider chemical reaction networks taken with mass action kinetics. The steady states of such a system are solutions to a system of polynomial equations. Even for small systems the task of finding the solutions is daunting. We develop an algebraic framework and procedure for linear elimination of variables. The procedure reduces the variables in the system to a set of "core" variables by eliminating variables corresponding to a set of non-interacting species. The steady states are parameterized algebraically by the core variables, and a graphical condition is given for when a steady state with positive core variables necessarily have all variables positive. Further, we characterize graphically the sets of eliminated variables that are constrained by a conservation law and show that this conservation law takes a ...

2011-01-01

106

Role of protracted exposure on the toxicology of inhaled "2"3"9PuO_2

Experiments have been reported previously in which lead-212 ions with lead carrier were instilled into the lungs of anaesthetised rabbits. Experiments were also reported in which bismuth-207 chloride was instilled into rabbit lung. To check that the chloride compound was cleared in the same way as ions instilled in isolation, lead-203 chloride has been instilled in three rabbits. Measurements of absorption of ionic lead have been repeated using the radon-222 daughter, lead-214. Rates of clearance from the lung of "2"0"3Pb as the chloride and "2"1"2Pb ions are compared, and retention functions are derived. Clearance from the lung of "2"1"4Pb ions is also shown, and retention functions are derived. (U.K.).

1978-03-01

107

Influence of the high-affinity growth hormone (GH)-binding protein on plasma profiles of free and bound GH and on the apparent half-life of GH. Modeling analysis and clinical applications.

Studies were initiated to examine in rats the effects of a protracted exposure to inhaled "2"3"9PuO_2. Graphs are presented to show effect of multiple exposures to "2"3"9PuO_2 on the deposition and clearance of "2"3"9Pu in the alveoli.

1977-05-01

108

Dynamic Deformation and Recovery Response of Red Blood Cells to a Cyclically Reversing Shear Flow: Effects of Frequency of Cyclically Reversing Shear Flow and Shear Stress Level

The discovery of a specific high-affinity growth hormone (GH) binding protein (GH-BP) in plasma adds complexity to the dynamics of GH secretion and clearance. Intuitive predictions are that such a protein...Full Text Available

1993-02-01

109

Device for laying cut peat in a drying formation

Dynamic deformation and recovery responses of red blood cells (RBCs) to a cyclically reversing shear flow generated in a 30-μm clearance, with the peak shear stress of 53, 108,...Full Text Available

2006-09-01

110

100 Areas: (For Technical Progress Letter No. 97), May 7--13

A device for laying cut peat in drying formations is proposed consisting of separate compartments, reinforced on a common frame and with mechanisms for both vertical and horizontal mixing. In order to intensify the drying process, within the scope of laying cut peat, uniform clearances and spacing in formations is applied. The mixing compartments are joined in sections with capabilities for separate mixing in each unit. The compartments are joined together by hinges and can be turned 180 degrees on the hinges horizontal to the plane.

1980-06-17

111

The DNA and RNA specificity of eilatin Ru(II) complexes as compared to eilatin and ethidium bromide

Physics information for the D and F piles is presented. Thermal conductivity, reactivity, and irradiation levels are included. Concerning the cooling systems: process water control, pressure drip studies, purging studies, corrosion, and gun barrel clearance of expanded graphite are discussed. (GHH)

1946-05-17

112

The Acidic Domain of Hepatitis C Virus NS4A Contributes to RNA Replication and Virus Particle Assembly?

Eilatin-containing ruthenium complexes bind to a broad range of different nucleic acids including: calf thymus (CT) DNA, tRNA^Phe, polymeric RNAs and DNAs, and viral RNAs including the HIV-1...Full Text Available

2003-10-01

113

Safety and immunogenicity of ERA strain of rabies virus propagated in a BHK-21 cell line.

Hepatitis C virus NS3-4A is a membrane-bound enzyme complex that exhibits serine protease, RNA helicase, and RNA-stimulated ATPase activities. This enzyme complex is essential for viral genome replication...Full Text Available

2011-02-01

114

SIV antigen immunization induces transient antigen-specific T cell responses and selectively activates viral replication in draining lymph nodes in retroviral suppressed rhesus macaques

The ERA strain of rabies virus was propagated in a baby hamster kidney cell line (BHK-21/C13). The viral titer was 10(1.8) tissue culture infective doses (TCID) higher than that of commercial ERA vaccine....Full Text Available

1989-10-01

115

Roles of the TNF receptor-associated factor (TRAF)2/3 binding site in differential B cell signaling by CD40 and its viral oncogenic mimic, latent membrane protein 1 (LMP1)

BackgroundHIV infection causes a qualitative and quantitative loss of CD4⁺T cell immunity. The institution of anti-retroviral therapy (ART) restores CD4⁺T...Full Text Available

116

Reversible conformational change in herpes simplex virus glycoprotein B with fusion-from-without activity is triggered by mildly acidic pH

The Epstein-Barr virus protein, LMP1, is a functional mimic of the cellular receptor CD40, but signals to B lymphocytes in an amplified and sustained manner compared to CD40. LMP1 contributes...Full Text Available

2009-09-01

117

Quantitation of transcribing native simian virus 40 minichromosomes extracted from CV1 cells late in infection.

BackgroundThe pre-fusion form of the herpes simplex virus (HSV) fusion protein gB undergoes pH-triggered conformational change in vitro and during viral entry (Dollery...Full Text Available

118

Practical approach to the loss of smell

Simian virus 40 transcriptional complexes could be extracted from CV1 cells late in infection and separated from the bulk of inactive viral chromatin. Sucrose gradient sedimentation, cesium sulfate...Full Text Available

1981-04-01

119

Morphological, Histochemical, Immunohistochemical, and Ultrastructural Characterization of Tumors and Dysplastic and Non-Neoplastic Lesions Arising in BK Virus/tat Transgenic Mice

Loss of the sense of smell can be easily confirmed in any physician's office by having the patient try to identify various odors. The etiology of anosmia can be extremely varied, including nasopharyngeal disorders such as rhinitis and tumors; neurologic conditions such as head trauma, neoplasms, vascular lesions and infections of the central nervous system; viral infections; familial and congenital disorders; drugs; industrial exposure; endocrine diseases, and several other disorders. The prognosis of anosmia is guarded, and its treatment depends on the etiology.

1982-09-01

120

NAME=\\

Wastenet

... All rickettsial diseases respond to treatment with antibiotics such as doxycycline and tetracycline As of 10 May, the Government of South Africa has reported 186 confirmed cases of RVF in humans, including 18 deaths, in Free State Province, Eastern Cape Province, Northern Cape Province, Western Cape, and North West Province. RVF is a viral disease that primarily affects animals (such as cattle, buffalo, sheep, goats and camels). The disease can also affect humans. The main mode of transmission of RVF ...

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121

Large T1 oligonucleotides of Moloney leukemia virus missing in an env gene recombinant, HIX, are present on an intracellular 21S Moloney viral RNA species.

To study the role in AIDS pathogenesis of the human immunodeficiency virus type 1 (HIV-1) Tat protein, a transactivator of viral and cellular genes, we generated transgenic mice with a recombinant DNA...Full Text Available

1999-04-01

122

Interferon-? expressed by a rabies virus-based HIV-1 vaccine vector serves as a molecular adjuvant and decreases pathogenicity

HIX, a recombinant derived from Moloney leukemia virus, has an envelope glycoprotein different from that of the Moloney virus. HIX and Moloney viruses share the majority of the large T1 oligonucleotides...Full Text Available

1978-06-01

123

Inhibition of Melanoma Growth by Subcutaneous Administration of hTERTC27 Viral Cocktail in C57BL/6 Mice

Type I interferon is important in anti-viral responses and in coordinating the innate immune response. Here we explore the use of interferon-β to adjuvant the response to a rabies virus...Full Text Available

2008-12-20

124

Individual products of the adenovirus 12S and 13S EIa mRNAs stimulate viral EIIa and EIII expression at the transcriptional level.

BackgroundhTERTC27 is a 27 kDa C-terminal polypeptide of human telomerase reverse transcriptase that has previously been shown to reduce tumorigenicity of HeLa cells and suppress...Full Text Available

125

Human endogenous retrovirus HERV-K(HML-2) encodes a stable signal peptide with biological properties distinct from Rec

Recombinant plasmids containing mutant or wild-type adenovirus serotype 2 EIa genes that produce the 12S mRNA alone, the 13S mRNA alone, or both mRNAs were cotransfected into HeLa cells with plasmids...Full Text Available

1984-07-01

126

Hepatitis C Virus RNA Replication Requires a Conserved Structural Motif within the Transmembrane Domain of the NS5B RNA-Dependent RNA Polymerase ?

BackgroundThe human endogenous retrovirus HERV-K(HML-2) family is associated with testicular germ cell tumors (GCT). Various HML-2 proviruses encode viral proteins such as Env and...Full Text Available

127

Hepatitis B virus-induced defect of monocyte-derived dendritic cells leads to impaired T helper type 1 response in vitro: mechanisms for viral immune escape

Hepatitis C virus (HCV) nonstructural protein 5B (NS5B), the viral RNA-dependent RNA polymerase (RdRp), is a tail-anchored protein with a highly conserved C-terminal transmembrane domain (TMD) that...Full Text Available

2010-11-01

128

Expression of alternatively spliced human T-lymphotropic virus type I pX mRNA in infected cell lines and in primary uncultured cells from patients with adult T-cell leukemia/lymphoma and healthy carriers.

Dendritic cells (DC) are the most potent antigen-presenting cells and play a central role in the induction of antiviral immune responses. Recently, we have shown that monocyte-derived DC (MoDC) from...Full Text Available

2003-08-01

129

Enhanced ?₂-adrenergic receptor (?₂AR) signaling by adeno-associated viral (AAV)-mediated gene transfer

Although human T-cell lymphotropic virus type I (HTLV-I) is the etiologic agent of adult T-cell leukemia/lymphoma (ATL), the role of viral gene expression in the progression to and maintenance of the...Full Text Available

1992-04-01

130

Duck Egg-Drop Syndrome Caused by BYD Virus, a New Tembusu-Related Flavivirus

Backgroundβ₂-Adrenergic receptors (β₂AR) play important regulatory roles in a variety of cells and organ systems and are important therapeutic...Full Text Available

131

Differential Specificity and Immunogenicity of Adenovirus Type 5 Neutralizing Antibodies Elicited by Natural Infection or Immunization?

Since April 2010, a severe outbreak of duck viral infection, with egg drop, feed uptake decline and ovary-oviduct disease, has spread around the major duck-producing regions in China. A new virus, named...Full Text Available

132

Comparison of prevalence, viral load, physical status and expression of human papillomavirus-16, -18 and -58 in esophageal and cervical cancer: a case-control study

A recent clinical trial of a T-cell-based AIDS vaccine delivered with recombinant adenovirus type 5 (rAd5) vectors showed no efficacy in lowering viral load and was associated with increased risk of...Full Text Available

2010-01-01

133

Analysis of the transcript encoding the latent Epstein-Barr virus nuclear antigen I: a potentially polycistronic message generated by long-range splicing of several exons.

BackgroundHuman papillomavirus (HPV) infection is a major risk factor for the development of nearly all cases of cervical cancer worldwide. The presence of HPV DNA in cases of esophageal...Full Text Available

134

Amino-Terminal Region of the Human Immunodeficiency Virus Type 1 Nucleocapsid Is Required for Human APOBEC3G Packaging

The Epstein-Barr virus nuclear antigen (EBNA I) present in latently infected cells is encoded in a 2-kilobase exon contained in the BamHI K viral genomic fragment. This exon is, however, found within...Full Text Available

1985-12-01

135

Temporal and Spatial Variability of the TOMS Total Ozone; Global Trends and Profiles

APOBEC3G exerts its antiviral activity by targeting to retroviral particles and inducing viral DNA hypermutations in the absence of Vif. However, the mechanism by which APOBEC3G is packaged into virions...Full Text Available

2004-11-01

136

Seasonal variability of leaf area index and foliar nitrogen in contrasting dry-mesic tundras

Full Text Available

2005-04-01

137

DEFF Research Database (Denmark)

Udgivelsesdato: May 2009

2009-01-01

138

Seasonal Relationship between El Nino-Southern Oscillation and Hydrologic Variables in Korea

Optimal Design of a Variable-Speed Cam for Power Circuit Breaker

Full Text Available

2007-04-01

139

Lead-203 for skeletal imaging

Full Text Available

2001-12-01

140

Inter-annual variability of a zooplankton community: the importance of summer concentrated rainfall in a regulated river ecosystem

... biological variability body distribution kidneys labelled compounds lead 203

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141

Confrontation between stellar pulsation and evolution; Proceedings of the Conference (ASP Series, Vol. 11), Bologna, Italy, May 28-31, 1990

Full Text Available

2011-03-01

142

Quantitative assessment of cancer risk from exposure to diesel engine emissions

Attention is given to the folowing topics: population I and II variable stars; LP variables, the sun, and mass determination; and predegenerate and degenerate variables. Particular papers are presented on alternative evolutionary approaches to the absolute magnitude of the RR Lyrae variables; the evolution of the Cepheid stars; nonradial pulsations in rapidly rotating Delta Scuti stars; dynamical models of dust shells around Mira variables; and pulsations of central stars of planetary nebulae.

1990-05-28

143

Preparation and biodistribution of technetium-99m-labeled 1-(2-nitroimidazole-1-yl)-propanhydroxyiminoamide (N2IPA) as a tumor hypoxia marker

Quantitative estimates of lung cancer risk from exposure to diesel engine emissions were developed using data from three chronic bioassays with Fischer 344 rats. Human target organ dose was estimated with the aid of a comprehensive dosimetry model. This model accounted for rat-human differences in deposition efficiency, normal particle clearance rates, transport of particles to lung-associated lymph nodes, respiration rates, and lung surface area, as well as high-dose inhibition of particle clearance. Recent evidence indicates that the inert carbon core of the diesel particulate matter is likely to be the primary source of carcinogenicity. The epithelial tissue lining the alveoli and lower airways is the primary target site for induction of lung tumors. Dose was therefore based upon the concentration of carbon particulate matter per unit lung surface area. Unit risk estimates were developed using either a time-to-tumor or a linearized ...

1993-02-01

144

Influence of compound grease on the performance of premium connections

A new hydroxyiminoamide ligand, 1-(2-nitroimidazole-1-yl)-propanhydroxyiminoamide (N2IPA) was synthesized. The biodistribution of {sup 99m}Tc-N2IPA in mice bearing S180 tumor demonstrated that the complex showed a selective accumulation in tumor and slow clearance from it. The tumor-to-tissue uptake ratios increased with time. At 4 hours after injection, the uptake ratios of tumor to muscle, blood, liver, heart, and lung reached 8.4, 1.5, 0.6, 2.9, and 2.3, respectively. Moreover, the tumor-to-liver uptake ratio steadily increased to 0.9 at 8 hours and 2.3 at 24 hours. The complex showed little uptake and quick clearance in blood, lung and other organs. Compared with other proposed hypoxia-imaging agents, this novel agent has advantages of higher tumor-to-muscle and tumor-to-blood uptake ratios and easier synthesis.

2004-02-01

145

Effect of heat transfer augmentation by square rod array in impinging air jet system(heat transfer characteristic of potential core region)

The authors investigated the harmful effect of compound grease on premium connections. The pressure buildup of compound grease trapped between threads was measured during and after makeup of the connection. The resulting hoop stress in the coupling and the reduction in the seal interference were also measured. Mathematical models were developed to calculate coupling stress and grease pressure. Results indicate that for the conventional API buttress-thread profile, the pressure of trapped compound grease remains permanently high after the connection is made up because of the small thread-clearance area. This high pressure results in a high coupling stress and a large reduction in seal interference diameter, thereby degrading the integrity of the connection. To solve this problem, the thread profile was redesigned with a thread-clearance area larger than that of conventional buttress thread. The connection with the new thread design showed a ...

1990-03-01

146

Analysis of the roles of E6 binding to E6TP1 and nuclear localization in the human papillomavirus type 31 life cycle

This research has been proceeded over the potential core region (H/B=2) of two-dimensional impinging air jet system, in which square rods(width of 6 mm) has been set up in front of heating surface in order to increase heat transfer. The objective of this research was to investigate the characteristics of heat transfer and air flow, in cases of the clearance from rods to heating surface (C = 1, 2, 4, 6 mm) and the pitch between each rods(P = 30, 40, 50 mm) changed. And this research compared the above with the experimentation without rods. As result, heat transfer performance was best under the condition of C = 1 mm, in case clearance changed, and there was no serious difference in the effect of heat transfer augmentation in the case of pitch of rods changed. (author) 11 refs. 12 figs.

1995-07-01

147

British Library Electronic Table of Contents (United Kingdom)

The E6 oncoproteins of high-risk human papillomaviruses provide important functions not only for malignant transformation but also in the productive viral life cycle. E6 proteins have been shown to bind to a number of cellular factors, but only a limited number of analyses have investigated the effects of these interactions on the viral life cycle. In this study, we investigated the consequences of HPV 31 E6 binding to E6TP1, a putative Rap1 GAP protein. HPV 16 E6 has been shown to bind as well as induce the rapid turnover of E6TP1, and similar effects were observed with HPV 31 E6. Mutation of amino acid 128 in HPV 31 E6 was found to abrogate the ability to bind and degrade E6TP1 but did not alter binding to another ?-helical domain protein, E6AP. When HPV 31 genomes containing mutations a...

2007-01-01

148

The onset conditions of enhancement of ice accumulation associated with heat-conducting plates located perpendicularly to heat-transfer surfaces; Part 1: Analysis for still water

Rapid clearance of iodine-131 MIBG from the heart and liver of patients with adrenergic dysfunction and pheochromocytoma

An analytical study of the ice-formation process associated with heat-conducting plates located perpendicularly to isothermally heated and cooled surfaces with some clearance is presented. It is proposed that the onset conditions, which describe whether the ice-volume fraction in a steady state is greater than or less than that without heat-conducting plates, are defined by the dimensionless distances between the heated/cooled walls and the heat-conducting plates. It is shown that the onset conditions are dependent on the pitch and the thickness of the heat-conducting plates and are less dependent on the thermal conductivity of the plates.

1994-07-01

149

Performance of rubber heat-stable and radiation-stable seals in helium coolant lines

Iodine-131 MIBG, a radiolabeled adrenergic neuron-blocking agent, decreased rapidly from the heart and liver of patients with adrenergic dysfunction and pheochromocytoma when compared with eight controls. However, there was no significant difference in the rate of (/sup 131/I)MIBG decrease in these organs between controls and patients in the intervals subsequent to 4 hr. These findings suggest that adrenergic neuronal uptake of (/sup 131/I)MIBG in these organs is smaller in the patients than in the controls. Measurements of time-activity relationships of radioiodinated MIBG may be useful for assessment of adrenergic function of these organs and thus of generalized disorders of adrenergic innervation.

1985-04-01

150

Fiber optic feedthrough module and method of making same

The integrity of helium circulation loop flanged joints has been attracting recent attention as a design problem, in the development of high-temperature facilities incorporating helium loops (e.g., the VRG-50 pilot nuclear facility). Elevated temperatures and pressures, and the radiation environment, impose additional requirements on sealant materials. This applies first and foremost to rubber seals, which have found widespread favor on account of its excellent elasticity, its ability to spontaneously conform to possible changes in the clearance in the seal assembly, and the low compressive stresses developed in the flange joint assembly.

151

Effect of tritium and helium-3 on the lifetime properties of Pd-Ag alloys in ITER tritium purification technology

A fiber optic feedthrough module which comprises a metal sleeve, a fiber optic element extending through the sleeve in spaced relation thereto, and a tandem series of centrally-apertured mating annular sealant bodies of thermoplastic material surrounding the fiber optic element and compressed between it and the sleeve. The module is made by first providing a loose subassembly of a plurality of individual but interfitting sealant bodies on the fiber optic element and then inserting this subassembly into a metal sleeve, following by swaging the whole assembly which eliminates clearances and provides sealed interfaces between the various contacting components. (author).

1983-05-25

152

Cocarcionogenesis of inhaled plutonium dioxide and beryllium oxide

An experimental verification for long-term performance of a Pd-Ag permeation in ITER tritium fusion cleanup units (FCU) is needed. In addition, information is required on the influence of tritium and {sup 3}He decay on the physical and chemical properties of Pd-Ag alloys (V-1). The results of the investigations of alloys (V-1) (mechanical properties and microstructure) after long-term usage exposition in tritium are given in this report. The experimental conditions (temperature, pressure, clearance, {sup 3}He concentrations) and the previous conclusions on the V-1 alloy performance are presented. (orig.).

1996-10-01

153

Clinical aspects of Marburg hemorrhagic fever

Inhaled beryllium oxide results in impaired alveolar clearance of inhaled "2"3"9PuO_2 and induces an inflammatory reaction in the lung. However, only one of 184 rats exposed to beryllium developed a lung tumor; none of 128 unexposed rats developed a lung tumor. Fifty-six lung tumors were induced in 181 rats exposed to plutonium. A total of 37 lung tumors were found in 119 rats given combined exposures to beryllium and plutonium. Only in rats given the highest levels of both beryllium and plutonium was there an incidence of lung tumors greater than that seen with exposure to plutonium only.

1977-05-01

154

British Library Electronic Table of Contents (United Kingdom)

Marburg virus belongs to the genus Marburgvirus in the family Filoviridae and causes a severe hemorrhagic fever, known as Marburg hemorrhagic fever (MHF), in both humans and nonhuman primates. Similar to the more widely known Ebola hemorrhagic fever, MHF is characterized by systemic viral replication, immunosuppression and abnormal inflammatory responses. These pathological features of the disease contribute to a number of systemic dysfunctions including hemorrhages, edema, coagulation abnormalities and, ultimately, multiorgan failure and shock, often resulting in death. A detailed understanding of the pathological processes that lead to this devastating disease remains elusive, a fact that contributes to the lack of licensed vaccines or effective therapeutics. This article will review the...

2011-01-01

155

Safe detection of Co-60. New perspectives in contamination and clearance measurements

Prediction of response of blood lead to airborne and dietary lead from volunteer experiments with lead isotopes

Consistent application of a newly developed coincidence technique to determine activation products in the operation and demolition of nuclear facilities results in very new perspectives in contamination monitoring and clearance measurement of plant components. In particular, it is possible to avoid the critical spread of point-source Co-60 contamination, the so-called hot particles. The CCM (Cobalt Coincidence Measurement) technique includes the coincident detection of prompt-prompt gamma cascades with "6"0Co and other activation products ("1"1"0"mAg, "1"2"4Sb, "2"2Na) with low mass-specific limits for unrestricted clearance. Special features of the technique are the short measurement times, excellent signal-to-noise ratio, and focusing in space achieved. Compared to conventional integral gamma-measurements, the signal-to-background ratio can be improved by 1-2 orders of magnitude. The method can be employed especially where conventional ...

156

Nod2 sensing of lysozyme-digested peptidoglycan promotes macrophage recruitment and clearance of S. pneumoniae colonization in mice.

To predict the response of blood lead to airborne and dietary lead requires knowledge of the rate of uptake of lead into the body from lung and gut, its subsequent partitioning between compartments, the stay time in those compartments, and its redistribution or excretion. Tracer studies with volunteers have shown no differences in systemic distribution of inorganic lead between tissues whether it is taken by inhalation, ingestion or injection. Lead is rapidly transferred from plasma to red cells, and there is slower movement thence into liver and other soft tissues, to bone, and to excreta. Work at Harwell and elsewhere with /sup 203/Pb has shown that the initial rapid distribution leaves rather over half the assimilated lead attached to red cells. The result is remarkably consistent, and applies also to dogs and baboons. The renal clearance (Vu) (ratio of U to CB, or daily urinary output expressed as mass of blood having the same lead content), and also the ...

1985-04-22

157

Experimental studies of 4-inch pipe whip test under BWR LOCA conditions

Streptococcus pneumoniae colonizes the mucosal surface of the human upper respiratory tract. A colonization event is gradually cleared through phagocytosis by monocytes/macrophages that are recruited to the airway lumen. Here, we sought to define the bacterial and host factors that promote monocyte/macrophage influx and S. pneumoniae clearance using intranasal bacterial challenge in mice. We found that the recruitment of monocytes/macrophages required their expression of the chemokine receptor CCR2 and correlated with expression of the CCR2 ligand CCL2. Production of CCL2 and monocyte/macrophage recruitment were deficient in mice lacking digestion of peptidoglycan by lysozyme (LysM) and cytosolic sensing of the products of digestion by Nod2. Ex vivo macrophages produced CCL2 following bacterial uptake, digestion by LysM, and sensing of peptidoglycan by Nod2. Sensing of digested peptidoglycan by Nod2 also required the pore-forming toxin pneumolysin. The generation ...

2011-08-15

158

Comparison of /sup 99/Tcsup(m) complexes (NEP-DADT, ME-NEP-DADT and HMPAO) with /sup 123/IAMP for brain SPECT imaging in dogs

Pipe whip tests or jet discharge tests have been performed at the Japan Atomic Energy Research Institute, which simulate the instantaneous circumferential guillotine break of primary coolant piping in nuclear power plants. The present paper describes the results of the pipe whip tests using test pipes of 4 inch diameter, under the BWR LOCA conditions, which were performed from 1979 to 1981. The tests were carried out at an initial pressure of about 6.8 MPa and an initial temperature of about 285/sup 0/C. The test pipe was 114.3 mm (4 in) in diameter, 8.6 mm in thickness and 4500 mm in length. The four pipe whip restraints used in the tests were the U-bar type of 8 mm in diameter and frabricated from Type 304 stainless steel. The experimental parameters were the clearance (30, 50 and 100 mm) and the overhang length (250, 400, 550 and 1000 mm). The main purpose of these tests is to investigate the effects of the clearance and the overhang length ...

1983-10-01

159

Virostatic potential of micro-nano filopodia-like ZnO structures against herpes simplex virus-1.

In this study we have compared brain uptake and blood clearance of /sup 99/Tcsup(m)-N-ethylpiperi-dinediamino dithiol (/sup 99/Tcsup(m)-NEP DADT), its 4-methylated derivative (/sup 99/Tcsup(m)-Me-NEP-DADT) and /sup 99/Tcsup(m)-hexamethyl-propylene-amine-oxime (/sup 99/Tcsup(m)-HMPAO) with that of N-isopropyl(/sup 123/I)iodoamphetamine (/sup 123/IAMP) in two dogs. Single photon emission tomography (SPECT) was employed to measure brain accumulation and retention of the four radiopharmaceuticals. Cerebral uptake of the /sup 99/Tcsup(m) complexes was lower than that of /sup 123/IAMP. There was considerable extracerebral activity in the dog's head, especially in the olfactory and snout regions. Because of slow blood clearance, /sup 99/Tcsup(m)-HMPAO showed high uptake in these regions. Brain uptake of /sup 99/Tcsup(m)-HMPAO reached a plateau 5 to 10 min after intravenous injection and remained constant for the entire study period (1 h). ...

1987-08-01

160

Increased Prevalence of Albuminuria in HIV-Infected Adults with Diabetes

Herpes simplex virus type-1 (HSV-1) entry into target cell is initiated by the ionic interactions between positively charged viral envelop glycoproteins and a negatively charged cell surface heparan sulfate (HS). This first step involves the induction of HS-rich filopodia-like structures on the cell surface that facilitate viral transport during cell entry. Targeting this initial first step in HSV-1 pathogenesis, we generated different zinc oxide (ZnO) micro-nano structures (MNSs) that were capped with multiple nanoscopic spikes mimicking cell induced filopodia. These MNSs were predicted to target the virus to compete for its binding to cellular HS through their partially negatively charged oxygen vacancies on their nanoscopic spikes, to affect viral entry and subsequent spread. Our results demonstrate that the partially negatively charged ZnO-MNSs efficiently trap the virions via a novel virostatic mechanism rendering them ...

2011-08-26

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161

Variable Pathogenicity Determines Individual Lifespan in Caenorhabditis elegans

ObjectiveHIV and type 2 diabetes are known risk factors for albuminuria, but no previous reports have characterized albuminuria in HIV-infected patients with diabetes.Research Design and MethodsWe performed a cross-sectional study including 73 HIV-infected adults with type 2 diabetes, 82 HIV-infected non-diabetics, and 61 diabetic control subjects without HIV. Serum creatinine >1.5 mg/dL was exclusionary. Albuminuria was defined as urinary albumin/creatinine ratio >30 mg/g.ResultsThe prevalence of albuminuria was significantly increased among HIV-infected diabetics (34% vs. 13% of HIV non-diabetic vs. 16% diabetic control, p?=?0.005). HIV status and diabetes remained significant predictors of albuminuria after adjusting for age, race, BMI, and blood pressure. Albumin/creatinine ratio correlated significantly with HIV viral load (r?=?0.28, p?=?0.0005) and HIV-infected subjects with albuminuria had significantly greater cumulative exposure to abacavir ...

2011-09-13

162

Variability In Motor Learning: Relocating, Channeling and Reducing Noise

A common property of aging in all animals is that chronologically and genetically identical individuals age at different rates. To unveil mechanisms that influence aging variability, we identified markers...Full Text Available

2011-04-01

163

The Characterisation of Three Types of Genes that Overlie Copy Number Variable Regions

Variability in motor performance decreases with practice but is never entirely eliminated, due in part to inherent motor noise. The present study develops a method that quantifies how performers...Full Text Available

2009-02-01

164

Numerical optimization of spherical variable-line-spacing grating X-ray spectrometers

BackgroundDue to the increased accuracy of Copy Number Variable region (CNV) break point mapping, it is now possible to say with a reasonable degree of confidence whether a gene...Full Text Available

165

Intra-Individual Variability in Alzheimer's Disease and Cognitive Aging: Definitions, Context, and Effect Sizes

Operation of an X-ray spectrometer based on a spherical variable-line-spacing (VLS) grating is analyzed using dedicated ray-tracing software allowing fast optimization of the grating parameters and...Full Text Available

2011-03-01

166

Guided Cell Migration on Microtextured Substrates with Variable Local Density and Anisotropy

Background/AimsTo explore different definitions of intra-individual variability (IIV) to summarize performance on commonly utilized cognitive tests (Mini Mental State Exam; Clock...Full Text Available

167

Considerable Variability in Platelet Activity among Patients with Coronary Artery Disease in Response to an Increased Maintenance Dose of Clopidogrel

This work reports the design of and experimentation with a topographically patterned cell culture substrate of variable local density and anisotropy as a facile and efficient platform to guide...Full Text Available

2009-02-06

168

Comparative optimism in models involving both classical clinical and gene expression information

BackgroundVariable platelet response to clopidogrel has been widely observed. Studies have shown that the mean aggregation response to clopidogrel can be changed...Full Text Available

2009-05-01

169

Adaptive Thresholding for Improving Sensitivity in Single-Trial Simultaneous EEG/fMRI

BackgroundIn cancer research, most clinical variables have already been investigated and are now well established. The use of transcriptomic variables has raised two problems: restricting...Full Text Available

170

The Climatological Characteristics of Monthly Precipitation over Han- and Nakdong-river Basins: Part I. Variability of Area Averaged Time Series

A common approach used to fuse simultaneously recorded EEG and fMRI is to correlate trial-by-trial variability in the EEG, or variability of components derived therefrom, with the blood oxygenation...Full Text Available

171

Spatial Variability of Reactive Mineral and Radionuclide Kd Distributions in the Tuff Confining Unit: Yucca Flat, Nevada Test Site

Full Text Available

2005-02-01

172

Mira variables - Pulsation, mass loss and evolution

Abstract not provided

2008-03-03

173

Asymptotic functions of many variables and singular operations with Schwartz distributions

Recent developments in the analysis of Mira atmosphere, the determination of the pulsation mode, the problem of mass loss, and the evolution of the Mira variables are covered. Model atmospheres for Mira variables, including the opacities of the molecules expected in very late M-type atmospheres are discussed. The pulsation constant for Omicron Ceti is evaluated using T(eff) = 2900 + or - 200 K, and it is concluded that Miras are fundamental mode pulsators. The importance of molecular opacity to the driving of mass loss is evaluated, and it is pointed out that the radiation pressure on molecules is not a major factor in driving mass loss from Mira. Mass loss is considered as a factor in the calculations of the periods for Mira variables. 30 refs.

1990-05-28

174

A Simulation Model for Estimating Airport Terminal Area ...

A theory of the asymptotic functions for the case of many variables is presented. It is shown that the class F(R"N) of these generalized functions is closed in respect to the linear algebraic and analytic operations, multiplication as well as a set of linear and polynomial changes of the variables. The existence in F(R"N) of analogues (consistent with the linear operations) of the Schwartz distributions with point support is proved. In terms of these analogues, some formulae for singular products and changes of variables of the Dirac #delta#-function and its derivatives #delta#"("i")(x), x is an element of R"N, are given. (author). 14 refs.

1992-10-19

175

Variable-speed hydro evolves

... AIR TRAFFIC, TERMINAL FLIGHT ... FLIGHT, RANDOM VARIABLES, STOCHASTIC PROCESSES ... COMPUTER PROGRAMS, QUEUEING THEORY. ...

1971-05-01

176

Tidal spin-up and magnetic braking in cataclysmic variables

Success in improving hydropower project efficiency has opened more global markets for variable-speed generator technology. Manufacturers continue to test the markets as the technology evolves. The potential of variable-speed application becomes evident considering that more than 150 pumped storage plants, with a combined capacity exceeding 100,000 MW, are in operation globally.

1993-10-01

177

Moderate deviations for stationary sequences of Hilbert valued bounded random variables

Based on proposed models for the tidal spin-up and magnetic braking of stars with a convective outer envelope, it is suggested that the rotation of secondaries in cataclysmic variables is not necessarily synchronized with the orbital revolution. This may provide an explanation for the observed large range in the mass transfer rate (at the same orbital period) of cataclysmic variables above the period gap. (author).

178

Long-run determinants of pollution: A robustness analysis

In this paper, we derive the moderate deviation principle for stationary sequences of bounded random variables with values in a Hilbert space. The conditions obtained are expressed in terms of martingale-type conditions. The main tools are martingale approximations and a new Hoeffding inequality for non adpated sequences of Hilbert-valued random variables. Applications to Cramer-Von Mises statistics, functions of linear processes and stable Markov chains are given.

2008-01-01

179

British Library Electronic Table of Contents (United Kingdom)

This paper examines how robust economic, political, and demographic variables are related to water and air pollution. Employing Bayesian Averaging of Classical Estimates (BACE) for a cross section of 47 countries, 34 variables and 3 proxies for air and water pollution over a period from 1980 to 2000 we confirm the environmental Kuznets curve hypothesis and highlight the relevance of variables that are not directly related to production.

2009-01-01

180

Joint distributions and tachyons

EUVE Observations of Nonmagnetic Cataclysmic Variables

In recent years there has been a renewed interest in the treatment of quantum mechanics in terms of joint distribution functions, i.e. functions of momentum and position coordinates p and q. The author considers j.d.f. in the sense of classical probability theory of a stochastic variable. The j.d.f. is then interpreted as the probability that the variables p and q have certain values, the variables being considered as a property possessed by the object system. This formalism is used to provide a unified description of bradyons and tachyons. (Auth.).

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

181

Circadian and circatrigintan respiratory and related intermodulations in the crab Barytelphusa guerini.

The authors summarize EUVE's contribution to the study of the boundary layer emission of high accretion-rate nonmagnetic cataclysmic variables, especially the dwarf novae SS Cyg, U Gem, VW Hyi, and OY Car in outburst. They discuss the optical and EUV light curves of dwarf nova outbursts, the quasi-coherent oscillations of the EUV flux of SS Cyg, the EUV spectra of dwarf novae, and the future of EUV observations of cataclysmic variables.

2001-09-05

182

On the development of a new methodology for groundwater-driven health risk assessment

Respiration and related physiologic variables in different tissues of Barytelphusa guerini and the respiration of this freshwater crab as a whole are closely synchronized in phase and in frequency along the circadian scale, in the face of large differences in circadian amplitude. A very close timing of most of the 36 variables examined in 2 separate circadian profiles and a modulation of some of these variables in added profiles as a function of lunar stage are clearly demonstrable, statistically significant and illustrative of time relations at 2 interacting frequencies. PMID:6745009

183

Uptake of Pb by human skeleton and comparative metabolism of Pb and alkaline earth elements

A methodology and hypothetical case study are presented for incorporation of uncertainty and variability into calculations of human health risk appropriate for regional, or basin-scale, groundwater management problems. Uncertainty in well water concentration is introduced through complex contaminant migration patterns in the subsurface. Variability is considered in parameters related to individual behavior patterns and biological effects and to groundwater extraction and distribution networks. A joint uncertainty and variability (JUV) analysis is used to generate a two-dimensional distribution or risk surface that spans both transport uncertainty as well as individual variability. Cuts in this distributional surface (fractiles of variability and percentiles of uncertainty) are presented and discussed. Comparisons with alternative approaches based upon deterministic transport models ...

1998-01-01

184

The NCRP wound model: development and application.

Measurements of the retention of /sup 47/Ca and of /sup 203/Pb were made following their administration by intravenous injection. Translocation to bone was measured by ..gamma.. counting the feet of subjects. Uptake by bone of /sup 203/Pb was comparatively slow and extrapolation to the whole skeleton indicated that 20% of the dose has been taken up within 20 days. By time, a similar fraction of the dose has been excreted in urine. Uptake by bone of /sup 47/Ca was about 1.5-2 times the amount excreted in urine. Both the uptake by bone, and its excretion in urine, were more rapid than that of /sup 203/Pb due to the greater attachment of the latter to red blood cells. However, the plasma clearance rate for Pb, like that of Sr, was greater than that of Ca.

1984-12-01

185

Susceptibility to invasive bacterial infections in children with sickle cell disease

The US National Council on Radiation Protection and Measurements, in collaboration with the International Commission on Radiological Protection, has been developing a biokinetic and dosimetric model for radionuclide-contaminated wounds. The finalised model is described briefly in this paper, together with the scientific basis and application. The multicompartment model uses first-order linear biokinetics to describe the retention and clearance of a radionuclide deposited in a wound site using seven default retention categories. Examples using plutonium nitrate in colloidal form and uranium in metal fragments show the behaviour of the less soluble forms of radionuclides in wounds, in which long-term retention is predicted. Using uranium as an example, the wound model is coupled to a uranium International Commission on Radiological Protection systemic model to predict urinary excretion patterns for different physicochemical forms of uranium. The latter application is ...

2007-08-31

186

British Library Electronic Table of Contents (United Kingdom)

Individuals with sickle cell disease (SCD) demonstrate an increased susceptibility to invasive bacterial infections (IBI). The most common organisms causing IBI are Streptococcus pneumoniae, nontyphi Salmonella species and Haemophilus influenzae type b (Hib). IBI are the most common causes of death in children below 5 years of age with SCD. Increased susceptibility to IBI is because of several factors including dysfunctional antibody production and opsonophagocytosis as well as defective splenic clearance. Early diagnosis of Hib and pneumococcal infections combined with antibiotic prophylaxis and immunization programs, could lead to significant improvements in mortality, especially in Africa. Pediatr Blood Cancer. 2010;55:401-406. Copyright 2010 Wiley-Liss, Inc.

2010-01-01

187

Study on a transportation and emplacement system of pre-assembled EBS module for HLW geological disposal

Radiolabelled peanut lectin for the scintigraphy detection of cancer

HLW disposal is one of the largest issue to utilize Nuclear power safely. In the past study, the concept, which buffer materials and Overpacked waste were transported into underground respectively, have shown. The concept of pre-assembled engineered barrier has advantage to simplify the logistics and emplacement procedure, however there are difficulties to support heavy weight of pre-assembled package by equipment under the condition of little clearance between tunnel and package. In this study, Combination of air bearing and two degree-of-freedom wheels were suggested for transportation, and air jack was suggested for unloading and emplacement system. Also, whole system for transportation and emplacement procedure was designed, and Scale model test was examined to evaluate the feasibility of these concept and functions. (author)

2009-11-01

188

Parametric study of pipe whip behavior

To investigate the role of intravenously administered, radioiodinated peanut lectin ("1"3"1I-PNA) in the non-invasive detection of cancer, the pharmacokinetics and scintigraphic distribution of this novel tumor-seeking compound were studied in 8 patients with metastatic cancer of the colon, breast or lung. Scintigraphic localization of "1"3"1I-PNA was apparent at certain anatomical sites of known metastases in 2 patients and in a further 2 patients an adjacent malignant pleural effusion was visualized. The rapid clearance of radioactivity from the whole body and plasma with marked renal concentration and rapid urinary excretion of significant amounts of intact "1"3"1I-PNA (mol.wt. 107,000,pI 5.95) implied that this molecule was excreted selectively by the renal tubules. PNA or other lectins may find a role in the scintigraphic detection of selected types of cancer. (author).

1984-01-01

189

Nonlinear response and stability of a spindle system supported by Ball bearings

A pipe whip test is one of the main subjects of the pipe rupture tests performed in Japan Atomic Energy Research Institute. In 1979, the pipe whip test of 4B, sch-80 pipe will be done under the BWR condition. As the preliminary analysis of this test, the pipe whip analysis of 4B, sch-80 pipe was implemented in order to make clear of the influences of the physical parameters on the pipe whip behavior. The pipe whip analysis was treated as nonlinear dynamic analysis of pipe-restraint system by using the general purpose finite element program ADINA. Overhang length, clearance between pipe and restraint, restraint length and cross section area of restraint were taken as physical parameters. It was clarified through this analysis how restraint displacement, restraint strain and distribution of energy between pipe and restraint were influenced by these parameters. (author).

190

Nigeria's radioactive waste management policy and strategy document

In this effort, the nonlinear responses and stability of a spindle system supported by ball bearings are presented. The dynamics of this system is described by a set of second order differential equations with a nonlinear piecewise smooth force. The Floquet theory is applied to investigate the stability of the periodic solution. Due to the loss of contact between the raceways and balls in the ball bearing, the bending of the frequency response curves switch to the left at the weak resonance region, which is similar to the frequency response curves of a system with a soft spring. With the decrease of the bearing clearance, the bending of the frequency response curves switch to the right, which is similar to the frequency response curves of a system with a hard spring. Increase of the frequency ratio, the bending of frequency response curves transforms from left to right. The route to chaos through a period doubling process is also observed in this spindle-bearing ...

2010-09-15

191

NURE aerial gamma-ray and magnetic reconnaissance survey: southeastern area-Alaska Quadrangles. Volume I. Narrative report

Radioactive waste for legal and regulatory purposes may be defined as material that contains or is contaminated with radio-nuclides at concentrations or activities greater than clearance levels as established by the regulatory body, and for which no use is foreseen. Safe management of radioactive waste is essential to ensure protection of humans and environment. Radioactive waste management policy is a guideline for the safe management of radioactive waste. It expresses the commitment of the country towards the goal. Government should initiate investigation into best long-term option for management of spent nuclear fuels. Process of selecting option and eventual site should involve comprehensive public participation within set time frames (with deep geological disposal as preferred management option).

2009-07-14

192

Low frequency noise from MW wind turbines -- mechanisms of generation and its modeling

A rotary-wing, reconnaissance high sensitivity radiometric and magnetic survey covering the Alaska portion of twenty-nine 1:250,000 UTMS quadrangles. A total of 21,409 line miles (34,455 line kilometers) of data were collected during the 1976 and 1977 flying seasons. This report covers only the Southeastern area comprised of the Skagway, Atlin, Mt. Fairweather, Juneau, Taku River, Sitka, Port Alexander, Sumdum, Petersburg, Bradfield Canal, Craig, Dixon Entrance, Ketchikan, and Prince Rupert NTMS 1:250,000 scale quadrangles which were flown during the 1976 and 1977 seasons. The radiometric data were normalized to 400 feet terrain clearance. The data are presented in the form of computer listings on microfiche and as stacked profile plots. A geologic interpretation of the radiometric and magnetic data is included in this volume.

193

Evaluation of the hepatobiliary function with "9"9"mTc-EHIDA imaging during total parenteral nutrition

During the present project the mechanisms of generation of low frequency noise (LFN) for upwind rotors has been investigated. A 3.6 MW turbine has been simulated with a noise prediction model from NASA in US. Running the model on this turbine a number of important turbine design parameters with influence on the LFN have been identified as well as other parameters not linked to the turbine design. Of important parameters can be mentioned 1) rotor rotational speed, 2) blade/tower clearance, 3) rotor configuration - upwind/downwind, 4) unsteadiness/turbulence in inflow. Further, the directivity characteristics of LFN has been computed as well as reduction in noise as function of distance from the turbine. In general low levels of LFN has been computed for the upwind rotor in standard configuration. (au)

2008-04-15

194

Estimates of quantitative genetic parameters of immunological traits in the chicken.

14 surgical patients with non-hepatobiliary diseases were studied with "9"9"mTc-EHIDA imaging to evaluate the effect of total parenteral nutrition (TPN) on the hepatobiliary function. Duration of TPN ranged from 6-56 days, 10 of the 14 patients Beijing within 10 days. The results showed that: (1) 11 of 14 patients had abnormal scintigraphic features. The most prominet findings were delayed liver excretion and prolonged blood clearance time. This fact suggests that not only the rate of excretion of the bile from the liver is decreased but the uptake ability of the hepatorcyte is also impaired. (2) The effect of TPN on liver function is reversible. It was concluded that in order to prevent irreversible damage of hepatobiliary function caused by TPN, the duration of TPN should not be too long and oral intake of nutrients should be resumed as soon as possible.

195

Eating the enemy in Crohn's disease

Three in vivo assays were used to measure the immunocompetence of chickens in two generations of a selection experiment. The obtained data were used to estimate the variance components for sire and dam for antibody production to Pasteurella multocida and Mycoplasma gallisepticum vaccines, for T-cell-mediated immunity evaluated by a phytohemagglutinin wing web assay, and for clearance of foreign particles from the circulatory system. Heritabilities of and genetic correlations among these immunological traits were calculated from the sire variance components. Heritability estimates of the immunological traits based on the sire component of variance ranged from .06 to .53, and genetic correlations among immunological traits were generally negative. PMID:1956847

1991-10-01

196

British Library Electronic Table of Contents (United Kingdom)

Several old and new observations suggest the existence in Crohn's disease of a phagocytic disorder of macrophages related to impaired bactericidal activity of host cells or to the presence of invasive bacteria that have developed strategies to counteract macrophage killing. It was recently reported that disordered macrophage cytokine secretion underlies impaired acute inflammation and bacterial clearance in Crohn's disease. Secretion of proinflammatory cytokines by CD macrophages was impaired in response to E. coli or specific Toll-like receptor agonists. In addition, major advances in the etiology of Crohn's disease came from the existence of polymorphism in NOD2 and autophagy-related susceptibility genes (ATG16L1 and IRGM) in patients and from the identification of the presence of adhere...

2010-01-01

197

Autoradiographic study of regional distribution of gastric mucosal blood flow

A study on the transient analysis of pipe and restraint due to impact loading

Iodo(/sup 14/C)antipyrine autoradiography was used to measure gastric mucosal blood flow in anesthetized rats and to study regional distribution. Blood flows of 61 +/- 8 ml.100 g-1.min-1 (means +/- SE) in corpus and 84 +/- 9 ml.100 g-1.min-1 in antral mucosa compared well with previously reported measurements by hydrogen clearance. Blood flow in the crests of corpus mucosal folds was significantly higher than in the valleys between folds, indicating that the greater susceptibility of the former areas to acute injury, documented in several studies, is not associated with a perfusion defect in the resting stomach. Corpus mucosal blood flow was also higher in the side walls of the stomach than in the greater curvature region, and in distal than in proximal locations. No systematic regional variations within antral mucosa were demonstrated.

1988-04-01

198

A study on the experimental verification for the pipe whip problem in a Nuclear Power Plant

In this study, experiments were performed for pipe whip phenomena simulation. The analytical method was developed by combining several kinds of elements in ABAQUS computer code, standard version 5.2 . The transient analytical and the experimental results of the pipe whip test using 6 inch diameter pipe and U-shaped restraints are presented. It is shown that the adequate clearance decreases the restraint strains. As the overhang length increased, the maximum strain of restraints decreased. When the impact force increased, the maximum restraint strain increased slightly. The analytical models simulate the experimental impact phenomena very precisely, with slight conservatism. It is verified that the analytical method developed is very suitable to pipe whip phenomena analysis in nuclear power plants. 6 refs., 10 figs., 1 tab.

1995-12-31

199

A network security case study; The Los Alamos National Laboratory integrated computer network

The purpose of this study is to investigate on the experimental verification analysis for the pipe whip problems and to obtain the quantitative evaluation technologies for the design technique of pipe whip restraints. These will contribute to the advance of nuclear regulatory technologies and enhance nuclear power plant safety. This study presents the experimental and transient analytical results of pipe whip tests using the 4', 6' diameter pipe and U-shaped restraints. In the tests, the effects of the overhang length, clearance, impact height on the pipe whip behavior of the pipe-restraints were investigated. The transient impact analysis of the pipe-restraint system was conducted by the finite element program ABAQUS. The applicability of the ABAQUS program to the pipe whip analysis is made clear through this analysis.

1993-12-15

200

A Hypothesis: Supplementation with Mushroom-Derived Active Compound Modulates Immunity and Increases Survival in Response to Influenza Virus (H1N1) Infection.

This paper reports on a study to validate the Graphical Network Representation (GRPHREP) model which is being conducted on the Los Alamos National Laboratory Integrated Computer Network (ICN). The GRPHREP model is a software system application based on graph theory and object-oriented programming methodologies. It codified the Department of Energy (DOE) Order 5637.1, which is concerned with classified computer secret policy, restrictions, and requirements. The Los Alamos ICN is required to control access to and support large-scale scientific and administrative computing. Thus, large-scale scientific and administrative computing. Thus we felt that this large, complex, and dynamic network would provide a good test for the graphical and functional capabilities of the model. Furthermore, the ICN is composed of multiple partitions that reflect the sensitivity and classification of the computation (data) and designate the required clearance level for the user.

1991-01-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

201

Targeted integration of baboon endogenous virus in the BEVI locus on human chromosome 6.

We hypothesize that the mushroom-derived active compound may be a potential strategy for increasing survival in response to influenza virus (H1N1) infection through the stimulation of host innate immune response. The validity of the hypothesis can be tested by immune response to influenza infection as seen through survival percentage, virus clearance, weight loss, natural killer cell cytotoxicity, Tumor Necrosis Factor-? (TNF-?) and Interferon-gamma (IFN-?) levels, lytic efficiency in the spleens of mice and inducible nitric oxide synthase mRNA expressions in RAW 264.7 murine macrophage cells. The hypothesis may improve people's quality of life, reduce the medical cost of our healthcare system and eliminate people's fears of influenza outbreak. PMID:21660092

2011-03-20

202

Ovis aries CR4 is involved in Mannheimia haemolytica leukotoxin-induced cytotoxicity

The infection of cultured human cells with baboon endogenous virus (BEV) frequently leads to an association of viral DNA with a specific genetic locus (termed BEVI, for baboon endogenous virus infection) on chromosome 6. Restriction endonuclease digestion of DNA from BEV-infected human cells and their derived somatic cell clones frequently revealed a common cellular DNA sequence in the proximity of one of the junctions between cellular DNA and the integrated virus. We propose that a short cellular DNA sequence, repeated on chromosome 6 and separated by unique DNA sequences, presents a high-affinity target for the integration of BEV in human cells. PMID:6401843

1983-01-13

203

Russell Group: Sitemap

Wastenet

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204

British Library Electronic Table of Contents (United Kingdom)

Pneumonia caused by Mannheimia haemolytica is an important disease of domestic sheep (DS, Ovis aries) and cattle (BO). M. haemolytica is a normal commensal of the upper respiratory tract in ruminants, but during stress and viral infection it breaches the host innate mucosal defense and descents into lungs causing fibrinous pleuropneumonia. Leukotoxin (Lkt) produced by M. haemolytica is cytolytic to all subsets of ruminant leukocytes. Earlier, we and others have shown that DS and BO LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18) can mediate Lkt-induced cytolysis. It is not clear whether CR4 (CD11c/CD18), which is involved in chemotaxis, phagocytosis and regulates host immune response can also mediate Lkt-induced cytolysis in ruminants. The host innate immune response to M. haemolytica is poorly ...

2010-01-01

205

Inhibitory effect of ?/?-carrageenan from red alga Tichocarpus crinitus on the development of a potato virus X infection in leaves of Datura stramonium L.

British Library Electronic Table of Contents (United Kingdom)

The effect of ?/?-carrageenan from red alda Tichocarpus crinitus on the development of a potato virus X (PVX) infection in the leaves of Datura stramonium L. has been studied. The treatment of leaves with carrageenan stimulates a protein synthesis in the cells, causing an increase in the size of nucleoli and in the number of mitochondria and membranes of the rough endoplasmic reticulum. At the same time, such treatment slightly stimulates lytic processes, causing an increase in the number of smooth endoplasmic reticulum cisternae, dictyosomes, and cytoplasmic vacuoles and the formation of cytoplasmic electron-transparent zones. The carrageenan-induced stimulation of lytic processes results in the destruction of viral particles and can be considered as one of the defense mechanisms, prevent...

2010-01-01

206

Immortalization of human foreskin keratinocytes by various human papillomavirus DNAs corresponds to their association with cervical carcinoma

Human papillomavirus: science and technologies for the elimination of cervical cancer

Normal human foreskin keratinocytes cotransfected with the neomycin resistance gene and recombinant human papillomavirus (HPV) DNAs (types 16, 18, 31, and 33) that have a high or moderate association with cervical malignancy acquired immortality and contained integrated and transcriptionally active viral genomes. Only transcripts from the intact E6 and E7 genes were detected in at least one cell line, suggesting that one or both of these genes are responsible for immortalization. Recombinant HPV DNAs with low or no oncogenic potential for cervical cancer (HPV1a, -5, -6b, and -11) induced small G418-resistant colonies that senesced as did the nontransfected cells. These colonies contained only episomal virus DNA; therefore, integration of HPV sequences is important for immortalization of keratinocytes. This study suggests that the virus-encoded immortalization function contributes to the pathogenesis of cervical carcinoma.

1989-01-01

207

British Library Electronic Table of Contents (United Kingdom)

Introduction: Academic research has made a significant advancement in understanding the viral causes of cervical cancer and generating the technology for prevention, both at the primary and secondary levels. Human papillomaviruses (HPVs) have been recognized as the first necessary cause of cervical cancer, the second most common cancer in women worldwide. Areas covered: This paper reviews the epidemiological evidence of the causality of HPV in relation to cervical cancer, other genital tract cancers and some cancers of the oral cavity and oropharynx. The review also covers HPV DNA testing as a screening tool. DNA probes of high-risk HPV types in different formats have been fully validated as primary screening tests, as secondary triage tests and as a prognostic marker following treatment o...

2011-01-01

208

Heparin binding sites on Ross River virus revealed by electron cryo-microscopy

Glycyrrhizin attenuates the development of carrageenan-induced lung injury in mice

Cell surface glycosaminoglycans play important roles in cell adhesion and viral entry. Laboratory strains of two alphaviruses, Sindbis and Semliki Forest virus, have been shown to utilize heparan sulfate as an attachment receptor, whereas Ross River virus (RRV) does not significantly interact with it. However, a single amino acid substitution at residue 218 in the RRV E2 glycoprotein adapts the virus to heparan sulfate binding and expands the host range of the virus into chicken embryo fibroblasts. Structures of the RRV mutant, E2 N218R, and its complex with heparin were determined through the use of electron cryo-microscopy and image reconstruction methods. Heparin was found to bind at the distal end of the RRV spikes, in a region of the E2 glycoprotein that has been previously implicated in cell-receptor recognition and antibody binding.

2005-02-20

209

British Library Electronic Table of Contents (United Kingdom)

Glycyrrhizin is a triterpene glycoside, a major active constituent of licorice (Glycyrrhiza glabra) root and numerous pharmacological effects like anti-inflammatory, anti-viral, anti-tumour and hepatoprotective activities has been attributed to it. In this study we evaluated the anti-inflammatory activities of glycyrrhizin in mice model of acute inflammation, carrageenan-induced pleurisy. We report here that glycyrrhizin (given at 10mg/kg i.p. 5min prior to carrageenan) exerts potent anti-inflammatory effects in this model. Injection of carrageenan into the pleural cavity of mice elicited an acute inflammatory response characterized by fluid accumulation in the pleural cavity which contained a large number of neutrophils (PMNs) as well as an infiltration of PMNs in lung tissues and subsequ...

2008-01-01

210

Familial unilateral deafness and delayed endolymphatic hydrops

British Library Electronic Table of Contents (United Kingdom)

Delayed endolymphatic hydrops (DEH) is a unique disorder characterized by fluctuating otologic symptoms in the setting of preexisting unilateral deafness. The symptoms include aural fullness, fluctuating hearing, and/or episodes of vertigo similar to those observed in Meniere disease and may occur ipsilateral or contralateral to the previously deafened ear. In most reported cases, the unilateral deafness has been a profound sensorineural hearing loss with a sudden onset that has been variously attributed to bacterial or viral labyrinthitis, acoustic or cranial trauma, otosclerosis, and congenital CMV infection. Familial occurrence of the syndrome has not previously been reported in the literature. In this report, we describe two possible familial instances of delayed DEH. These patients ra...

2007-01-01

211

Effect of radiation on certain animal viruses in liquid swine manure

Construction and Analytical Application of Internal Amplification Controls (IAC) for Detection of Food Supply Chain-Relevant Viruses by Real-Time PCR-Based Assays

The virucidal effect of _6_0Co gamma radiation was studied in cell culture medium and in liquid swine manure involving the most important porcine viruses that can be spread by liquid manure. The radiation doses (20 kGy and 30 kGy) were determined in preliminary experiments employing a porcine enterovirus from the serogroup 1 (Teschen group). In the main experiment, the following viruses were employed: swine vesicular disease (SVD) virus, type C foot-and-mouth disease (FMD) virus, a field strain of Aujeszky's disease (AD) virus, transmissible gastroenteritis (TGE) virus, as well as bovine viral diarrhoea (BVD) virus. The latter strain served as a model for hog cholera virus. The results of the experiments indicate that safe disinfection of the virus infected liquid swine manure by ionizing radiation requires a radiation dose of 30 kGy. (author).

1983-01-01

212

British Library Electronic Table of Contents (United Kingdom)

Internal amplification controls (IACs) were constructed for incorporation into real-time nucleic acid amplification assays for bovine polyomavirus, hepatitis A virus, hepatitis E virus, human adenovirus, human norovirus genogroup I, human norovirus genogroup II, murine norovirus and porcine adenovirus. The addition of optimised amounts of IAC into the assays did not affect the limits of detection for each specific target virus. A poorly performed extraction of viral nucleic acids was simulated, and the effectiveness of IACs in identifying failed assays was demonstrated. The IACs constructed in this study can be reliably used in their specific assays to provide a robust control that can be routinely applied in the analysis of foods for viruses.

2011-01-01

213

The implications of tolerance system interpretation on past and present dimensional variability studies

Man-made disasters: A cross-national analysis

Dimensional variability studies and published dimensional variability standards have been used by the foundry industry for years as an indicator of the casting process` ability to produce uniform parts. These studies are an extremely useful tool in the continuous ``dimensional dialogue`` between foundries and customers. The nature of these studies, and of the current tolerancing systems used by casting designers, leaves room for some misinterpretation and misuse of these study results. This paper contains two important discussions. The first part explains exactly what these studies represent. Following this is a brief explanation on dimensional and geometric tolerances and how they communicate dimensional requirements.

1994-12-31

214

British Library Electronic Table of Contents (United Kingdom)

This research investigates the impact of national culture and several institutional factors on the safety performance of society and establishes statistically significant relationships between those variables. As expected, the research results reveal that some cultural variables such as uncertainty avoidance, gender orientation and institutional variables such as the degree of law avoidance can directly influence the safety performance of the society. The findings also support the inverted u-curve (Safety Kuznet curve) hypothesis indicating even if we expect a negative trend at the beginning stage of industrialization, we can expect a positive trend in safety performance as their income level continues to improve beyond a certain point.

2011-01-01

215

Go vs. no-go - potential and limitations of continuous-variable quantum computing by measurements

Creep properties of modified 9 Cr-1 Mo steel

In this talk, we explore the feasibility of quantum computation using continuous-variable systems by means of local measurements only. In the first part of the talk, we will identify crucial limitations that arise when starting from Gaussian cluster states. This is done by resorting to a Gaussian projected entangled pair picture as well as to notions of continuous-variable quantum repeater networks. In the second part, we look at instances in which these limitations can be overcome, and how suitable encodings of qubits in oscillators and feasible non-Gaussian resource states give rise to universal schemes for quantum computing.

2010-07-01

216

Vascular Effects of Photodynamic and Pulsed Dye Laser Therapy Protocols

Creep properties of modified 9 Cr-1 Mo steel, an alloy significantly improved in elevated-temperature strength over 2 1/4 Cr-1 Mo and other similar alloys, are presented here. Data are primarily on material in the normalized and tempered condition. Effects of variables such as isothermal annealing treatment, cold work, normalizing temperature, tempering temperature, notch, and biaxial stress state have also been examined. Data analysis and comparisons have shown that modified 9 Cr-1 Mo alloy is very insensitive in response to several material variables, heat treatments, and specimen design variables.

1983-01-01

217

Variability in Melanoma Metalloproteinase Expression Profiling

Background and ObjectivePulsed dye laser (PDL) treatment of cutaneous vascular lesions is associated with variable and unpredictable efficacy. Thus, alternative treatment...Full Text Available

2008-11-01

218

The role of fatigue variability in life prediction of an #alpha#+#beta# titanium alloy

The proteolytic activities of a disintegrin and metalloproteinase (ADAM); a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS), and matrix metalloproteinase (MMP) families play important...Full Text Available

2010-12-01

219

Spatial and Temporal Variability of Column Integrated Aerosol - NASA

The fatigue life variability of the #alpha#+#beta# titanium alloy, Ti-6Al-2Sn-4Zr-6Mo increased with decreasing stress level. The variability in life was found to be due to segregation of lives due to two failure mechanisms. A bimodal cumulative distribution model was shown to accurately describe the combined failure modes. The nominal failure processes for the two regimes were similar, with crack nucleation occurring in equiaxed #alpha#p particles, irrespective of life or stress level. However the variability in life was not controlled by the size of the crack-nucleating #alpha#p, but rather by the ability of the material to distribute deformation and avoid early crack nucleation.

2004-06-10

220

Spatial Variability of Wave Data from Todos Santos Bay, Baja California, Mexico

the southern Arabian Gulf region left its signature on the heterogeneous aerosol .... Arabian Gulf region, since large differences in ? may be caused by ...

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221

Organismos que causan enfermedades transmitidas por los alimentos ...

... and operation of marine structures and to estimate coastal sediment transport. While the timely collection and report of high ... ...

222

Order in Spontaneous Behavior

... Variable, Alimentos mal enlatados, especialmente verduras enlatadas en el hogar; pescado fermentado, papas asadas en papel de aluminio, ajo envasado. ...

223

Optimization of extraction of high-ester pectin from passion fruit peel (Passiflora edulis flavicarpa) with citric acid by using response surface methodology

Brains are usually described as input/output systems: they transform sensory input into motor output. However, the motor output of brains (behavior) is notoriously variable, even under identical sensory...Full Text Available

224

British Library Electronic Table of Contents (United Kingdom)

A central composite design was employed to optimize the extraction of pectin with citric acid. The independent variables were citric acid concentration (0.086-2.91% w/v) and extraction time (17-102min). The combined effect of these variables on the degree of esterification was investigated. Results have shown that the generated regression models adequately explained the data variation and significantly represented the actual relationship between the independent variables and the responses. Besides that, the citric acid concentration was the most important factor to affect the degree of esterification, as it exerted a significant influence on the dependent variable. Lower citric acid concentration increased the pectin degree of esterification. The surface response showed the relationships b...

2008-01-01

225

Multifractal Analysis of Multiple Ergodic Averages

Modeling hydrologic responses to deforestation/forestation and ...

In this paper we present a complete solution to the problem of multifractal analysis of multiple ergodic averages in the case of symbolic dynamics for functions of two variables depending on the first coordinate.

2011-01-01

226

Koji Mukai's Bibliography - Astrophysics Science Division Staff ...

Worldwide century-long forest hydrologic research has documented that deforestation and forestation (i.e. reforestation and afforestation) can have variable ...

227

Fractal dynamics in physiology: Alterations with disease and aging

Jul 25, 2011 ... Koji Mukai's Bibliography. Invited Reviews. Mukai, K. 1994, "ASCA PV Phase Observations of Cataclysmic Variables," in "New Horizon of X-ray ...

228

Floral ontogeny of Annonaceae: evidence for high variability in floral form

According to classical concepts of physiologic control, healthy systems are self-regulated to reduce variability and maintain physiologic constancy. Contrary to the predictions of homeostasis, however,...Full Text Available

2002-02-19

229

Enhancement of bioleaching of a spent Ni/Mo hydroprocessing catalyst by Penicillium simplicissimum

Background and AimsAnnonaceae are one of the largest families of Magnoliales. This study investigates the comparative floral development of 15 species to understand the basis for...Full Text Available

2010-10-01

230

British Library Electronic Table of Contents (United Kingdom)

Statistically based experimental designs were applied to screen and optimize the bioleaching of spent hydrocracking catalyst by Penicillium simplicissimum. Eleven factors were examined for their significance on bioleaching using a Plackett-Burman factorial design. Four significant variables (pulp density, sucrose, NaNO"3, and yeast extract concentrations) were selected for the optimization studies. The combined effect of these variables on metal bioleaching was studied using a central composite design (CCD). Second-order polynomials were established to identify the relationship between the recovery percent of the metals and the four significant variables. The optimal values of the variables for maximum metals bioleaching were as follows: pulp density (4.0%, w/v), sucrose (90g/L), NaNO"3 (2...

2011-01-01

231

Effects of wildfires on environmental variability: a comparative analysis using different spectral indices, patch metrics and thematic resolutions

British Library Electronic Table of Contents (United Kingdom)

Knowledge on environmental variability and how it is affected by disturbances is crucial for understanding patterns of biodiversity and determining adequate conservation strategies. The aim of this study is to assess environmental variability in patches undergoing post-fire vegetation recovery, identifying trends of change and their relevant drivers. We particularly evaluate: the value of three spectral indices derived from Landsat satellite data [Normalized Burn Ratio (NBR), Normalized Difference Vegetation Index (NDVI) and Wetness Component of the Tasseled Cap Transformation (TCW)] for describing secondary succession; the effectiveness of three metrics (diversity, evenness and richness) as indicators of patch variability; and how thematic resolution can affect the perception of environme...

2010-01-01

232

Effects of Climatic Variability and Land Use on American Drylands...

ENSO affects sex ratio progeny in captive Iberian red deer despite a steady feeding regime

Wildlife Refuge, CA Rare and endangered endemic plants Diana Anderson Northern Arizona University Geomorphology Kathryn Thomas USGS, Flagstaff, AZ Vegetation dynamics John...

2011-09-30

233

British Library Electronic Table of Contents (United Kingdom)

Climate variability greatly affects animals through direct and indirect effects. Animals with slow reproductive adaptation to ecological changes such as large mammals are likely to have evolved mechanisms to anticipate early such impacts of climate variability on the environment. One of the adaptive mechanisms between reproductive costs and benefits in mammals affects parental investment through biases in sex ratio. Deer might be likely to show an early detection of climate variability because conception takes place in early autumn, but the main raising cost in deer concerns lactation, which takes place at the end of the following spring. The aim of this paper is to assess whether there is a relationship between global indices of climate variability such as El Ni?o-Southern Oscillation (EN...

2011-01-01

234

DESIGN STUDY OF CONTINUOUSLY VARIABLE ROLLER CONE - NASA Technical ...

Comparing Genomes within the Species Mycobacterium tuberculosis

pedel preo,ure. (_PD). VSO may be developed by nor_:el epeed-o-_eter means at the output. ,haft or it may be derived ...

235

Climate change/variability implications on hydroelectricity generation in the Zambezi River Basin

The study of genetic variability within natural populations of pathogens may provide insight into their evolution and pathogenesis. We used a Mycobacterium tuberculosis high-density...Full Text Available

2001-04-01

236

British Library Electronic Table of Contents (United Kingdom)

The study has analysed the effects of various factors on hydroelectric power generation potential to include climate change/variability, water demand, and installation of proposed hydroelectric power schemes in the Zambezi River Basin. An assessment of historical (1970?2000) power potential in relation to climate change/variability at existing hydro electric power schemes(Cahora Bassa, Kariba, Kafue Gorge and Itezhi-Tezhi) in the Zambezi River Basin was conducted. The correlation of hydroelectric power potential with climate change/variability aimed at observing the link and extent of influence of the latter on the former was investigated. In order to predict the future outlook of hydro electric power potential, General Circulation Models (GCM) were used to generate projected precipitation...

2011-01-01

237

Characterizing partial upwellings ... - Lake Tahoe Validation - NASA

Baxter Q-operator and Separation of Variables for the open SL(2,R) spin chain

measure meteorological variables and bulk water temper- ature. The locations of the buoys are given in Table 1. TB2 and TB3 were moved slightly farther south ...

238

Adaptive Pareto Set Estimation for Stochastic Mixed Variable ...

We construct the Baxter Q-operator and the representation of the Separated Variables (SoV) for the homogeneous open SL(2,R) spin chain. Applying the diagrammatical approach, we calculate Sklyanin's integration measure in the separated variables and obtain the solution to the spectral problem for the model in terms of the eigenvalues of the Q-operator. We show that the transition kernel to the SoV representation is factorized into the product of certain operators each depending on a single separated variable. As a consequence, it has a universal pyramid-like form that has been already observed for various quantum integrable models such as periodic Toda chain, closed SL(2,R) and SL(2,C) spin chains.

2003-01-01

239

A novel approach to the dynamics of Szekeres dust models

... Direct Search (SMOMADS) and Paciencia's NMADS [45] based on Kim and de Weck's ... Todd Paciencia for his foundational contributions. ...

2009-03-01

240

Vascular filtration function in galactose-fed versus diabetic rats: The role of polyol pathway activity

We obtain an elegant and useful description of the dynamics of Szekeres dust models (in their full generality) by means of "quasi--local" scalar variables constructed by suitable integral distributions that can be interpreted as weighed proper volume averages of the local covariant scalars. In terms of these variables, the field equations and basic physical and geometric quantities are formally identical to their corresponding expressions in the spherically symmetric LTB dust models. Since we can map every Szekeres model to a unique LTB model, rigorous results valid for the latter models can be readily generalized to a non--spherical Szekeres geometry. The new variables lead naturally to an initial value formulation in which all scalars are expressed as scaling laws in terms of their values at an arbitrary initial space slice. These variables also yield a significant simplification of numerical work, ...

2011-01-01

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241

Translocation of particles to the pleural space and tracheobronchial lymph nodes following lung deposition

These studies were undertaken to assess the effects of increased galactose (v increased glucose) metabolism via the polyol pathway on vascular filtration function in the kidneys, eyes, nerves, and aorta. Quantitative radiolabeled tracer techniques were used to assess glomerular filtration rate (GFR) and regional tissue vascular clearance of plasma 131I-bovine serum albumin (BSA) in five groups of male Sprague-Dawley rats: nondiabetic controls, streptozotocin-diabetic rats, nondiabetic rats fed a 50% galactose diet, diabetic rats treated with sorbinil (an aldose reductase inhibitor), and galactose-fed rats treated with sorbinil. Sorbinil was added to the diet to provide a daily dose of approximately .2 mmol/kg body weight. After 2 months of diabetes or galactose ingestion, albumin clearance was increased twofold to fourfold in the eye (anterior uvea, choroid, and retina), sciatic nerve, aorta, and kidney; GFR was increased approximately twofold ...

1990-07-01

242

Synthesis and tissue distribution of substituted [{sup 125}I]iodophenylamine derivatives: Possible brain imaging agents

The translocation of particles from the alveolar compartment to the pleural space and tracheobronchial lymph nodes was investigated in rats over a 30 day period following the intrapulmonary instillation of 4 x 10/sup 8/ polystyrene microspheres (1.9 ..mu..m dia.). In initial studies, approx. =10/sup 4/ particles were found in the pleural space compartment on Days 1, 14 and 30 after particle deposition, and most of these were cell-associated. Subsequent pleural space studies indicated, however, that the particles found in this compartment were, at least in part, due to the pleural lavage technique, and, unlike observations reported for some fibers, the translocation of the particles used in our study to the pleural space does not represent an important lung clearance pathway. In regard to particle clearance to the tracheobronchial lymph nodes, the accumulation of particles, most of which were extracellular, kinetically was biphasic with the most ...

1985-01-01

243

Synthesis and tissue distribution of substituted ["1"2"5I]iodophenylamine derivatives: Possible brain imaging agents

The synthesis and brain uptake in mice of the radioidinated derivatives of N,N-dimethyl-N'-(idodimethoxyphenyl)-1,3-propanediamine, as well as the N-substituted derivatives of (iodoalkylphenyl)isopropyl, iodoalkylphenylethylamine and 3,4-(methylenedioxy)phenyl-amphetamine (MDA) are described. These compounds contain structural features of both IMP and HIPDM, the cerebral perfusion agents currently in clinical use. The radiolabeled analogs were obtained via the [{sup 125}I]I exchange method, or by [{sup 125}I]NaI treatment of the iodo-free precursor in the presence of an oxidant. Following intravenous injection in mice, all compounds showed important radioactivity concentrations in the lungs and kidneys. The N-substituted (iodoalkylphenyl)isopropyl and iodoalkylphenyl-ethylamine derivatives displayed a high initial brain uptake (>10%IDg{sup -1}) followed by a rapid clearance phase, resulting in lower brain-to-blood ratios as those reported for IMP ...

1997-02-01

244

Synthesis and radiolabelling of cysteine derivatives and pharmacological behaviour of their "9"9"mTc complexes

The synthesis and brain uptake in mice of the radioidinated derivatives of N,N-dimethyl-N'-(idodimethoxyphenyl)-1,3-propanediamine, as well as the N-substituted derivatives of (iodoalkylphenyl)isopropyl, iodoalkylphenylethylamine and 3,4-(methylenedioxy)phenyl-amphetamine (MDA) are described. These compounds contain structural features of both IMP and HIPDM, the cerebral perfusion agents currently in clinical use. The radiolabeled analogs were obtained via the ["1"2"5I]I exchange method, or by ["1"2"5I]NaI treatment of the iodo-free precursor in the presence of an oxidant. Following intravenous injection in mice, all compounds showed important radioactivity concentrations in the lungs and kidneys. The N-substituted (iodoalkylphenyl)isopropyl and iodoalkylphenyl-ethylamine derivatives displayed a high initial brain uptake (>10%IDg"-"1) followed by a rapid clearance phase, resulting in lower brain-to-blood ratios as those reported for IMP and HIPDM. In contrast, ...

1997-02-01

245

Study on development of high performance evaporator for automotive air conditioner

Full text: HMPAO, a butane monoxime derivative of propylene amine and ECD, ethyl cysteinate dimer, are currently being used as brain imaging agents. In an effort to develop new radiopharmaceuticals for imaging brain, we have synthesized amine and imine derivatives of ethyl cysteinate with butane monoxime, optimized labelling procedure with "9"9"mTc and studied the in vivo behaviour of their "9"9"mTc complexes. Imine derivative of ethyl cysteinate with butane monoxime was synthesized by refluxing equimolar amounts of butane monoxime and ethyl cystinate in dry benzene for 3 hours. The product was purified over silica with 10% ethyl acetate in chloroform as eluent. Amine derivative was prepared by reducing the imine derivative with sodium borohydride. The ligands were characterized by NMR spectroscopy and were found to be pure. The ligands were labelled with "9"9"mTc using stannous chloride as reducing agent. The complexes were characterized by paper chromatography, paper electrophoresis ...

1998-09-01

246

Pulmonary clearance of soluble and insoluble forms of manganese

The object of the present study is to develop a high performance evaporator for automotive air conditioner. The experiment has been conducted on evaporative heat transfer coefficient inside a plate type heat exchanger with a sharp 180-degree turn flow. The test plates have different formed surface, cross-ribboned channel and elliptical-ribbed channel. Also experimental study has been performed to determine optimal design in elliptical-ribbed plate heat exchanger with different turn clearance. In addition to the above experiments, refrigerant behavior and surface temperature distribution in the plate heat exchanger were observed using color thermo viewer(infrared thermometer). In this experiment, working fluid was used R-12 and test conditions were as follows : (1) saturation pressure of 2,116 kg/cm{sup 2}, (2) mass fluxes of 40 to 70 kg/m{sup 2} s, (3) heat fluxes of 4,500 to 7,300 W/m{sup 2}, (4) inlet quality of 0.1 to 0.7. The results indicated that the ...

1995-02-01

247

Intestinal circulation during inhalation anesthesia

Manganese is an essential metal of toxicologic concern primarily because of exposure via inhalation. Environmental forms of Mn exist mainly as insoluble oxides, yet much of the research information available relates to the soluble salts. In the present study, adult male Sprague-Dawley rats were intratracheally instilled with either soluble MnCl/sub 2/ or insoluble Mn/sub 3/O/sub 4/ labeled with /sup 54/Mn. Lungs and other major organs were sampled over a span of 3 mo after dosing with the respective chemicals, which were equivalent to 8 ..mu..Ci and 1 ..mu..mol of manganese in 0.2 ml of buffer. There was rapid clearance of Mn from the lungs in the case of both chemicals; the chloride cleared at an initial rate of nearly four times that of the oxide. Despite this early difference, the amount of /sup 54/Mn remaining in the lungs after 2 wk was similar for both compounds. The level of /sup 54/Mn in the liver, kidney, spleen, and testes peaked at the 3-d sampling point ...

1986-01-01

248

Intestinal circulation during inhalation anesthesia

This study was designed to evaluate the influence of inhalational agents on the intestinal circulation in an isolated loop preparation. Sixty dogs were studied, using three intestinal segments from each dog. Selected intestinal segments were pumped with aortic blood at a constant pressure of 100 mmHg. A mixture of /sub 86/Rb and 9-microns spheres labeled with /sup 141/Ce was injected into the arterial cannula supplying the intestinal loop, while mesenteric venous blood was collected for activity counting. A very strong and significant correlation was found between rubidium clearance and microsphere entrapment (r = 0.97, P less than 0.0001). Nitrous oxide anesthesia was accompanied by a higher vascular resistance (VR), lower flow (F), rubidium clearance (Cl-Rb), and microspheres entrapment (Cl-Sph) than pentobarbital anesthesia, indicating that the vascular bed in the intestinal segment was constricted and flow (total and nutritive) decreased. ...

1985-04-01

249

Anatomic variations on PNS CT

This study was designed to evaluate the influence of inhalational agents on the intestinal circulation in an isolated loop preparation. Sixty dogs were studied, using three intestinal segments from each dog. Selected intestinal segments were pumped with aortic blood at a constant pressure of 100 mmHg. A mixture of _8_6Rb and 9-microns spheres labeled with "1"4"1Ce was injected into the arterial cannula supplying the intestinal loop, while mesenteric venous blood was collected for activity counting. A very strong and significant correlation was found between rubidium clearance and microsphere entrapment (r = 0.97, P less than 0.0001). Nitrous oxide anesthesia was accompanied by a higher vascular resistance (VR), lower flow (F), rubidium clearance (Cl-Rb), and microspheres entrapment (Cl-Sph) than pentobarbital anesthesia, indicating that the vascular bed in the intestinal segment was constricted and flow (total and nutritive) decreased. ...

250

Anatomic variations on PNS CT

To illustrate frequently encountered anatomic variations on PNS computed tomography(CT) and to assess their clinical significance. CT findings of 1523 patients, who underwent PNS CT with no history of sinus surgery, were reviewed, and prevalence of each anatomic variation and its relationship with mucociliary clearance pathway was evaluated. Two categories of anatomic variations were encountered. The first group included variations of the turbinates, such as concha bullosa(28.6%), paradoxical middle turbinate(31.5%), of the uncinate process, such as medially bent or folded(36.3%), laterally bent(3.7%) or uncinate bulla(0.5%), of the ethmoidal sinus, such as Haller's cell(28.2%), large agger nasi cell(9.6%) or large ethmoidal bulla(23.5%) and nasal septal deviation(24.1%), which might cause obstruction of mucociliary clearance pathway and thus give rise to secondary obstructive sinusitis. The second group included Onodi cell(1.4%) and ...

1994-09-15

251

Viral RNA testing and automation on the bead-based CBNE detection microsystem.

To illustrate frequently encountered anatomic variations on PNS computed tomography(CT) and to assess their clinical significance. CT findings of 1523 patients, who underwent PNS CT with no history of sinus surgery, were reviewed, and prevalence of each anatomic variation and its relationship with mucociliary clearance pathway was evaluated. Two categories of anatomic variations were encountered. The first group included variations of the turbinates, such as concha bullosa(28.6%), paradoxical middle turbinate(31.5%), of the uncinate process, such as medially bent or folded(36.3%), laterally bent(3.7%) or uncinate bulla(0.5%), of the ethmoidal sinus, such as Haller's cell(28.2%), large agger nasi cell(9.6%) or large ethmoidal bulla(23.5%) and nasal septal deviation(24.1%), which might cause obstruction of mucociliary clearance pathway and thus give rise to secondary obstructive sinusitis. The second group included Onodi cell(1.4%) and medial ...

1994-09-01

252

The Sorcerer II Global Ocean Sampling Expedition: Expanding theUniverse of Protein Families

We developed prototype chemistry for nucleic acid hybridization on our bead-based diagnostics platform and we established an automatable bead handling protocol capable of 50 part-per-billion (ppb) sensitivity. We are working towards a platform capable of parallel, rapid (10 minute), raw sample testing for orthogonal (in this case nucleic acid and immunoassays) identification of biological (and other) threats in a single sensor microsystem. In this LDRD we developed the nucleic acid chemistry required for nucleic acid hybridization. Our goal is to place a non-cell associated RNA virus (Bovine Viral Diarrhea, BVD) on the beads for raw sample testing. This key pre-requisite to showing orthogonality (nucleic acid measurements can be performed in parallel with immunoassay measurements). Orthogonal detection dramatically reduces false positives. We chose BVD because our collaborators (UC-Davis) can supply samples from persistently infected animals; and because ...

2008-09-01

253

Variable Frequency Microwave Synthesis of Silver Nanoparticles

Metagenomics projects based on shotgun sequencing of populations of micro-organisms yield insight into protein families. We used sequence similarity clustering to explore proteins with a comprehensive dataset consisting of sequences from available databases together with 6.12 million proteins predicted from an assembly of 7.7 million Global Ocean Sampling (GOS) sequences. The GOS dataset covers nearly all known prokaryotic protein families. A total of 3,995 medium- and large-sized clusters consisting of only GOS sequences are identified, out of which 1,700 have no detectable homology to known families. The GOS-only clusters contain a higher than expected proportion of sequences of viral origin, thus reflecting a poor sampling of viral diversity until now. Protein domain distributions in the GOS dataset and current protein databases show distinct biases. Several protein domains that were previously categorized as kingdom specific are shown to ...

2006-03-23

254

One-dimensional numerical simulation of free-electron laser (FEL) amplifier with incorporate variable-parameter wiggler magnets

Synthesis of silver nanoparticles based on a polyol process and variable frequency microwave (VFM) was investigated. Comparing to a thermal method, the reaction by VFM radiation was much faster. The effects of silver nitrate concentration, poly(N-vinylpyrrolidone) (PVP) concentration, reaction time and reaction temperature were studied. It was found that the higher concentration of silver nitrate, longer reaction time and higher temperature increased the particle size while the higher concentration of PVP decreased the particle size.

2006-02-15

255

Flow control with variable inflow as an alternative to conventional nozzle group control - automatic control of large capacity steam turbines

A physical model of free-electron laser (FEL) amplifier with variable-parameter wiggler magnets for one-dimensional numerical simulation is presented and a numerical example is given. The wiggler parameters, efficiency of energy conversion between electron beam and laser field, laser intensity, phase-space distributions and energy spectrum of electrons are computed. The period of synchronous oscillation and saturation value of laser intensity agree with estimated one.

256

Conference on climate and water. Volume 2

In the case of large capacity steam turbines the conventional nozzle group control is, for mechanical and thermodynamic reasons, diminishing more and more in importance in favour of variable pressure control. A design for constant-pressure operation as an alternative to nozzle group control is described; this demonstrates a series of important advantages compared with the latter. (orig.).

257

Conference on climate and water

This book contains the Proceedings of the Conference on Climate and Water under the following groupings: Impacts of climatic variability and change-resulting from the changes in hydrological variables; Aquatic environment; Terrestrial environment; Coastal zones and navigation; Urban and industrial water supply and drainage; Energy production; Intropogenic changes of climate and water management problems; Flood potential; Irrigation and land drainage.

1989-12-31

258

Variable-speed generation enhances hydro operation

This book contains the Proceedings of the Conference on Climate and Water under the following groupings: Impacts of climatic variability and change-resulting from the changes in hydrological variables; Aquatic environment; Terrestrial environment; Coastal zones and navigation; Urban and industrial water supply and drainage; Energy production; Intropogenic changes of climate and water management problems; Flood potential; Irrigation and land drainage.

1989-01-01

259

Intrapartum FHR monitoring and neonatal CT brain scan

Two major developments have given impetus to wider adoption of variable-speed turbine/generators in hydroelectric plants, both essentially environmental: (1) the need for stream-bed stability below river dams, and (2) the need to minimize fish damage. Also, the need to stabilize pumped-storage and generating efficiencies to match extreme changes in head levels has been a driving force. Variable-speed operation in hydro applications is relatively new to North America. In other parts of the world, it has been used in pumped-storage plants since 1971. In the US, and increasing potential exists for variable-speed hydro, considering the 30 pumped-storage plants already in operation and several river plants struggling with high head fluctuations--including four at stations operated by the Bonneville Power Administration. Several modifications to hydro-plant hardware and operating procedures are actively being considered at ...

1993-07-01

260

Intrapartum FHR monitoring and neonatal CT brain scan

The effect of fetal distress on the neonatal brain was investigated by neonatal CT brain scan, FHR monitoring and mode of delivery. This study involved 11 cases of full term vertex delivery in which FHR was recorded by fetal direct ECG during the second stage labor. All infants weighed 2,500 g or more. FHR monitoring was evaluated by Hon's classification. Neonatal brain edema was evaluated by cranial CT histgraphic analysis (Nakada's method). 1) Subdural hemorrhage was noted in 6 of 7 infants delivered by vacuum extraction or fundal pressure (Kristeller's method). 2) Intracranial hemorrhage was demonstrated in all of 3 infants with 5-min. Apgar score 7 or less. 3) Two cases with prolonged bradycardia and no variability had intraventricular or intracerebral hemorrhage which resulted in severe central nervous system damage. 4) The degree of neonatal brain edema correlated with 5-min. Apgar score. 5) One case with prolonged bradycardia and ...

1982-12-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

261

Variability of the physical properties of tuff at Yucca Mountain, NV

The effect of fetal distress on the neonatal brain was investigated by neonatal CT brain scan, FHR monitoring and mode of delivery. This study involved 11 cases of full term vertex delivery in which FHR was recorded by fetal direct ECG during the second stage labor. All infants weighed 2,500 g or more. FHR monitoring was evaluated by Hon's classification. Neonatal brain edema was evaluated by cranial CT histgraphic analysis (Nakada's method). 1) Subdural hemorrhage was noted in 6 of 7 infants delivered by vacuum extraction or fundal pressure (Kristeller's method). 2) Intracranial hemorrhage was demonstrated in all of 3 infants with 5-min. Apgar score 7 or less. 3) Two cases with prolonged bradycardia and no variability had intraventricular or intracerebral hemorrhage which resulted in severe central nervous system damage. 4) The degree of neonatal brain edema correlated with 5-min. Apgar score. 5) One case with prolonged bradycardia and no ...

1982-01-01

262

Polyp measurement based on CT colonography and colonoscopy: variability and systematic differences

Lateral and vertical variabilities in the bulk and mechanical properties of silicic volcanic tuff at the potential nuclear waste repository site in Yucca Mountain, NV have been evaluated. Laboratory measurements have been performed on tuff specimens recovered from boreholes located to support the design of the Exploratory Studies Facility/North Ramp. The data include dry and saturated bulk densities, average grain density, porosity, compressional and shear wave velocities, elastic moduli, and compressional and tensional fracture strengths. Data from eight boreholes aligned in a northwest-southeast direction have been collected under the required quality assurance program. Three boreholes have penetrated the potential repository horizon. The information collected provides for an accurate appraisal of the variability of rock properties in the vicinity of the boreholes. As expected, there is substantial variability in the bulk ...

1994-12-31

263

Utilization of Tc-99m-TBI as a myocardial perfusion agent in exercise studies: Comparison with Tl-201 thallous chloride and examination of its biodistribution in humans

To assess the variability and systematic differences in polyp measurements on optical colonoscopy and CT colonography. Gastroenterologists measured 51 polyps by visual estimation, forceps comparison and linear probe. CT colonography observers randomly assessed polyp size two-dimensionally (abdominal and intermediate window) and three-dimensionally (manually and semi-automatically). Linear mixed models were used to assess the variability and systematic differences between CT colonography and optical colonoscopy techniques. The variability of forceps and linear probe measurements was comparable and both showed less variability than measurement by visual assessment. Measurements by linear probe were 0.7 mm smaller than measurements by visual assessment or by forceps. The variability of all CT colonography techniques was lower than for measurements by forceps or visual assessment and ...

2010-06-15

264

Usefulness of myocardial imaging by [sup 123]I-MIBG in assessment of diabetic neuropathy

Twenty-four patients were studied with both /sup 201/Tl-thallus chloride and /sup 99m/Tc-TBI scintigraphy following exercise. Comparison of the two agents in detecting segmental myocardial ischemia and scar was made in 18 patients with evidence of coronary artery disease on /sup 201/Tl-thallous chloride scintigraphy. Agreement between the two studies was observed in 77% (125 of 162) of left ventricular segments, suggesting that /sup 99m/Tc-TBI can be used as a myocardial perfusion agent. Limitations were related to early high background activity from lungs and liver. The high lung activity and early myocardial redistribution within the 1st hour contributed to the failure of /sup 99m/Tc-TBI to detect 16 segmental defects seen in the immediate post-exercise thallous chloride scan. Persistently high liver activity additionally affected accurate interpretation in the left ventricular segments close to the diaphragm. Improvement in the accuracy of /sup 99m/Tc-TBI stress studies might be ...

1986-10-01

265

Tribo-characteristics of self-lubricating ball bearings for the LE-7 liquid hydrogen rocket-turbopump

In diabetic patients with autonomic neuropathy, it is suggested that there is a reduced uptake of [sup 123]I-metaiodobenzylguanidine (MIBG) in the heart. We compared the difference of myocardial [sup 123]I-MIBG accumulation between 4 diabetic patients with triopathy and 6 patients without it. In all 10 patients, coronary angiography and [sup 201]Tl imaging (rest and 4 hours later) were performed. [sup 123]I-MIBG (111 MBq) was administered intravenously and its imaging was recorded on 15 minutes and 4 hours after injection. In all 4 cases with triopathy, [sup 123]I-MIBG imaging showed defect in apical and inferior region. In 2 out of 6 cases without triopathy, rapid clearance was noticed in apical and inferior region. There was no significant stenosis in right coronary artery and no defect in initial and delayed [sup 201]Tl images in all cases. We concluded that diabetic autonomic neuropathy in the heart was prominent in apical and inferior region and [sup ...

1993-10-01

266

The chemistry of technetium(V) complexes containing tetradentate amine oxime ligands

The tribo characteristics of self-lubricating 40-mm-bore ball bearings with a retainer of glass cloth-polytetrafluoroethylene (PTFE) laminate, which has elliptical pockets with a large pocket clearance, were tested under thrust loads at speeds up to 50,000 rpm, 2 million DN, in liquid hydrogen (LH2) and in liquid nitrogen (LN2). During testing, the bearing torque, outer-race temperature, and electric resistance between the inner and outer races were monitored to verify the formation and rupture of a PTFE transfer film. Testing showed that the bearings having the elliptical retainer pockets were superior to the conventional bearings with circular pockets. It was determined that, at the maximum inner race spinning velocity of about 5 m/s, a PTFE transfer film could sustain the maximum Hertz stress, up to about 2000 N/sq mm, in LH2, without severe film rupture resulting in bearing seizure. In LN2, the critical load capacity of PTFE transfer film with bearing seizure ...

1993-07-01

267

Safety and Environmental Aspects of Inertial Fusion Energy: An Overview of Recent Activities and Developments in the United States

Technetium-99m was previously shown to form a stable, neutral and lipopholic complex with propylene amine oxime, PnAO. This Tc-99m-PnAO complex was shown to efficiently extracted by normal brain. However, it is not sufficiently retained in the brain to image its cerebral distribution using convertional SPECT (single-photon emission computerized tomography) instrumentation. A number of derivatives of PnAO have been synthesized and their technetium-99m complexes have been biologically evaluated. A number of these have been shown to have high brain uptake without exhibiting the rapid cerebral clearance that was observed with Tc-99m-PnAO. To better understand the chemistry of these potential brain imaging agents, a number of technetium-99 complexes of derivatives of PnAO have been synthesized and characterized. Substituents on the tetradentate amine oxime backbone were varied to probe the effect(s) of these structural changes on the properties of the resultant Tc(V) ...

268

Radioiodinated peanut lecitin: A potential radiopharmaceutical for immunodetection of carcinoma expressing the T antigen

During the past 2 yr, significant progress has been made in several areas related to the safety and environmental (S and E) aspects of inertial fusion energy (IFE). An updated methodology has been developed, and accident analyses have been performed for two IFE conceptual power plants and a target fabrication facility. Parallel to the consequence analyses of different accident scenarios, ongoing studies of accident initiating events are being used to support safety assessment and create a basic framework of types of events to consider in future risk characterization of new plant designs. Target designers/fabrication specialists have been provided with ranking information related to the S and E characteristics of candidate target materials. We have revisited waste management options for IFE, introducing the concept of clearance versus the traditional shallow land burial. A brief summary of results in each of these activities is given, and plans for future work are ...

2003-05-01

269

Radiation decontamination of dry food ingredients and processing aids

The Thomsen-Friedenreich (T) antigen, #betta#-D-Gal-(1->3)-#alpha#-D-GalNAc, is exposed in reactive form on many human adenocarcinomata, but not on corresponding benign tissues. Peanut lectin (PNA) has a strong binding affinity for the T antigen and reportedly binds preferentially to certain malignant tissues. We investigated the potential of radio-labelled PNA as a tumour localising agent in an animal model system using a mouse lymphoma (RI) shown to bind fluorescein-labelled PNA in vitro. The radio-iodinated lectin showed good tumour localisation and rapid blood clearance. Clear images of tumours were obtained, in serial scintigraphic imaging, by 24 and 48 h. No blood background subtraction was necessary. Biodistribution studies revealed tumour to blood ratios in mice were 6:1 (at 24 h) and 17:1 (at 48 h), and tumour to muscle ratios were 34:1 (at 24 h) and 40:1 (at 48 h). Rapid in vivo breakdown of _1_2_5I-PNA led to some localisation of free iodide in the ...

1983-01-01

270

Pharmacokinetics of multiple doses of valsartan in patients with heart failure.

Radiation decontamination of dry ingredients, herbs and enzyme preparations is a technically feasible, economically viable and safe physical process. The procedure is direct, simple, requires no additives and is highly efficient. Its dose requirement is moderate. Radiation doses of 3-10 kGy (0.3-1 mrad) have proved sufficient to reduce the viable counts to a satisfactory level. Ionising radiations do not cause any significant rise in temperature. The flavour, texture or other important technological or sensory properties of most ingredients are not influenced at radiation doses necessary for satisfactory decontamination, and radiation obviates the chemical residue problem. The microflora surviving radiation decontamination of dry ingredients are more susceptible to subsequent antimicrobial treatments. Recontamination can be prevented as the product can be irradiated in its final packaging. Irradiation could be carried out in commercial containers and would result in considerable ...

271

Noninvasive analysis of skin iron and zinc levels in beta-thalassemia major and intermedia

Angiotensin II has adverse actions in heart failure including vasoconstriction, aldosterone secretion, and activation of the sympathetic nervous system. Valsartan, a potent specific angiotensin II type 1 receptor blocker, may produce beneficial effects in heart failure. The purpose of this study was to evaluate the steady-state pharmacokinetics of valsartan 40, 80, and 160 mg each given every 12 h for 7 days in heart failure patients. Eighteen patients with chronic stable heart failure and left ventricular ejection fractions power model, showed that doubling the dose increased the AUC and Cmax 1.8 times. The pharmacokinetics of valsartan are predictable in heart failure patients within the dose range of 40-160 mg BID. Age did not appear to have influenced the valsartan clearance in heart failure patients. The pharmacokinetic values were higher in heart failure patients than in healthy volunteers. All doses were generally safe and well tolerated.(max) (max) ...

2002-11-01

272

Murine respiratory mycoplasmosis (MRM) in C57BL/6N and C3H/HeN mice: strain differences in early host responses and exacerbation by nitrogen dioxide

Diagnostic x-ray spectrometry, a method based on x-ray fluorescence analysis, was used for noninvasive determination of iron and zinc in two distinct skin areas, representing predominantly dermal and epidermal tissues, in 56 patients with beta-thalassemia major and intermedia. The mean iron levels in the skin of patients with beta-thalassemia major and intermedia were elevated by greater than 200% and greater than 50%, respectively, compared with control values. The zinc levels of both skin areas examined were within the normal range. The data indicate that the rate and number of blood transfusions, which correlated well with serum ferritin levels (r . 0.8), are not the only factors that determine the amount of iron deposition in the skin (r less than 0.6). Other sources of iron intake contribute to the total iron load in the tissues, particularly in patients who are not given multiple transfusions. The noninvasive quantitation of skin levels may reflect the extent of iron deposition ...

1985-01-01

273

Loss of PINK1 function decreases PP2A activity and promotes autophagy in dopaminergic cells and a murine model

The studies reported here used genetic differences in susceptibility of C57BL/6N and C3H/HeN mice and exacerbation of the disease by nitrogen dioxide (NO/sub 2/) as tools in assessing the role of early host responses in the pathogenesis of MRM. The two strains did not differ in susceptibility to infection, but C3H/HeN mice were more susceptible to and had increased severity of lung lesions 14 days after intranasal inoculation as determined by 50% biological endpoints and morphometric analysis of tissues. Exposure to NO/sub 2/ for 4 hours prior to exposure to infectious aerosols exacerbated murine respiratory mycoplasmosis (MRM) by 7 days after exposure in both mouse strains. NO/sub 2/ appeared to affect host lung defense mechanisms responsible for limiting mycoplasmal growth in the lungs. The NO/sub 2/ exposure concentration required for this effect varied with the genetic background of the host, the dose of mycoplasmas administered, and the endpoint measured. Pulmonary ...

1987-01-01

274

British Library Electronic Table of Contents (United Kingdom)

Parkinson's disease (PD) is the most common neurodegenerative movement disorder. Mutations in PTEN-induced kinase 1 (PINK1) are a frequent cause of recessive PD. Autophagy, a pathway for clearance of protein aggregates or impaired organelles, is a newly identified mechanism for PD development. However, it is still unclear what molecules regulate autophagy in PINK1-silenced cells. Here we report that autophagosome formation is promoted in the early phase in response to PINK1 gene silencing by lentivirus transfer vectors expressed in mouse striatum. Reduced PP2A activity and increased phosphorylation of PP2A at Y307 (inactive form of PP2A) were observed in PINK1-knockdown dopaminergic cells and striatum tissues. Treatment with C2-ceramide (an agonist of PP2A) reduced autophagy levels in PINK...

2011-01-01

275

Heat transfer augmentation due to surface radiative exchange effect of internal fins in an annulus

Four-inch pipe whip test under BWR LOCA conditions effect of overhang length

Heat transfer augmentation due to surface radiation in an annulus with fins was investigated both theoretically and experimentally for fully developed laminar flow. The system considered in the present study was an array of axially internal and straight fins attached to the outer tube wall. Analytical solutions were given for 4, 8, 16, 24, 32 fins and for the ratios of the fin height to the passage clearance, 0, 0.2, 0.4, 0.5, 0.6, 0.8. The experiments were performed with air as the working fluid for radius ratio of 1.45, 16 fins and for Reynolds numbers ranging from 500 to 2000. The numerically predicted results of the convective/radiative heat transfer for the present case were in good agreement with the experimental data. It was found that the heat transfer augmentation coefficient attained a maximum value of 1.45 for 32 fins and for a dimensionless fin height of 0.65.

1987-08-01

276

Evaluation of the hepatobiliary function with "9"9Tc"m EHIDA imaging during total parenteral nutrition

Pipe whip tests or jet discharge tests have been performed at the Japan Atomic Energy Research Institute, which simulate the instantaneous guillotine break of primary coolant piping in nuclear power plants. This paper describes the results of the 4-inch pipe whip tests(RUN 5407, 5501, 5504, 5603), under the BWR LOCA conditions, which were performed from 1979 to 1981. The test pressure was 6.8 MPa and test temperature 285/sup 0/C. In these tests, clearance was kept constant at the value of 100 mm and overhang lengths were 250, 400, 550 and 1,000 mm, respectively. The main purpose of these tests is to investigate the effect of overhang length on pipe whip behavior. From the tests results, the pipe movement is effectively limited by the restraints if the overhang length is 250 mm or 400 mm. The deformation of the test pipe and restraints becomes large with increasing overhang length. It is clarified that the test pipe collapses at the setting point of the restraints ...

1983-03-01

277

Effects of the. cap alpha. -adrenoceptor antagonists phentolamine, phenoxybenzamine, and Idazoxan on sympathetic blood flow control in the periodontal ligament of the cat

Fourteen surgical patients with non-hepatobiliary diseases were studied with "9"9Tc"m EHIDA imaging to evaluate the effect of total parenteral nutrition (TPN) on the hepatobiliary function. The duration of TPN ranged from 6 to 56 days; for 10 of the 14 patients it was between 6 to 10 days. The results showed that: (1) 11 of 14 patients had abnormal scintigraphic features. The most prominent findings were delayed liver excretion and prolonged blood clearance time. This fact suggests that not only the rate of excretion of the bile from the liver is decreased but the uptake ability of the hepatocyte is also impaired. (2) The effect of TPN on liver function is reversible. The authors conclude that in order to prevent irreversible damage of hepatobiliary function caused by TPN, the duration of TPN should not be too long and oral intake of nutrients should be resumed as soon as possible. (author). 9 refs, 3 figs, 3 tabs.

1988-08-15

278

Effect of vasopressin on ependymal and capillary permeability to tritiated water in cat

Blood flow changes in the periodontal ligament (PDL) were measured indirectly by monitoring the local clearance of /sup 125/I/sup -/ during electric sympathetic nerve stimulation or close intra-arterial infusions of either noradrenaline (NA) or adrenaline (ADR) before and after administration of phentolamine (PA), phenoxybenzamine (PBZ) or Idazoxan (RX). At the doses used in the present study, PA was the only antagonist that significantly reduced the blood flow decrease seen on activation of sympathetic fibers, although PBZ also reduced this response. Idazoxan, however, did not induce the consistent effect on blood flow decreases seen on sympathetic activation. All three ..cap alpha..-adrenoceptor antagonists almost abolished the effects of exogenously administered NA and ADR. The results suggest the presence of functional post-junctional adrenoceptors of both the ..cap alpha.. 1 and ..cap alpha.. 2 subtypes in the sympathetic regulation of the blood flow in the ...

1988-01-01

279

Effect of rib height and pitch of the thermal performance of a passage disturbed by detached solid ribs

Ependymal cells line the cerebral ventricles forming the interface that separates the cerebrospinal (CSF) and interstitial fluids (ISF). Extracellular molecules move between ependymal cells, whereas lipid soluble molecules pass both between and through cells. We measured the transfer of tritiated water (TOH) from CSF to blood across the ependymal and capillary interfaces by ventriculocisternal (VC) steady-state tissue clearance. Adult cats anesthetized with pentobarbital sodium underwent VC perfusion with the extracellular marker (/sup 14/C)sucrose and TOH added to the artificial CSF. Brain tissue was analyzed for depth of penetration of the isotopes into periventricular gray matter. We found that TOH distribution space was lower than expected from water content measurements, whereas sucrose space was normal. Using VC steady-state equations we calculated an ependymal permeability that was similar to the permeability of the cerebral capillary. When arginine ...

1986-09-01

280

Effect of external pressure on intramuscular blood flow at rest and after running

Laser holographic interferometry and pressure measurements are presented for the effects of rib-to-duct height ratio (H/2B), rib pitch-to-height ratio (Pi/H), and Reynolds number (Re) on the spatially periodic-fully developed turbulent heat transfer and friction in a rectangular duct of width-to-height ratio of 4:1 with an array of ribs detached from one wall at a clearance to rib-height ratio of 0.38. The ranges of H/2B, Pi/H, and Re examined were 0.13 to 0.26, 7 to 13, and 5 {times} 10{sup 3} to 5 {times} 10{sup 4}, respectively. The difference in the H/2B dependence of the thermal performance between the detached and attached solid-rib array is documented H/2B = 0.17 and Pi/H = 10 are found to provide the best thermal performance for the range of parameters tested. Compact heat transfer and friction correlations are developed. Additionally, it is found that heat transfer augmentation with a detached solid-rib array is superior to with a detached perforated-rib ...

1998-07-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

281

Diagnosing mechanical changes: A test of the machine condition monitoring concept

Local blood flow in the thigh was measured with /sup 133/Xe clearance technique in eight male distance runners after compression with a foam rubber compress and a standard elastic bandage. Two degrees of compression were tested, and an initial experiment with rested subjects was followed by a similar experiment immediately after running. Maximum compression exerted a cutaneous pressure of 85 (+/- 8) mm Hg and caused an immediate cessation of intra-muscular blood flow in the compressed area. Moderate compression gave a cutaneous pressure of 40 (+/- 5) mm Hg and resulted in a reduction of blood flow by approximately 50%. During compression, there were no significant differences in the blood flow of rested subjects compared to subjects immediately after running. In acute soft tissue injuries, a maximum compression bandage should effectively reduce or eliminate the formation of an intra-muscular hematoma, and an additive effect on blood flow of ice should not be ...

1987-10-01

282

Composite electrode substrate for fuel cell requiring no separator plate and its production method; Separeta ban wo fuyo tosuru nenryo denchiyo fukugo denkyoku kiban oyobi sono seizoho

BC Hydro recently conducted a demonstration test of a bearing condition monitor. The test, at the 529-MW Kootenay Canal project, proved the ability of the monitor to detect machine condition faults. The capability to detect changing conditions during normal operation of hydroelectric machines gives hydro plant owners the opportunity to anticipate needed maintenance and ultimately to reduce the number of equipment failures. BC Hydro intends to install bearing condition monitors, as well as windings monitors, brushgear monitors, environmental monitors, and other selected systems in as many as 46 of its hydro generators. BC Hydro analyzed forced outages between 1985 and 1989 in its hydro system to identify which parts of a generating unit resulted in the highest number of hours of outage. From there, the utility has formulated a concept for a machine condition monitoring system. To keep the system cost effective, it will be developed in modules. In this way, users can pick and choose from ...

1993-05-01

283

CT findings after normal and unsuccessful functional endoscopic sinus surgery; Ruolod della tomografia computerizzata dopo chirurgia funzionale dei seni paranasali: rilievi normali e valutazioni degli insuccessi chirurgici

This invention relates to the production method of composite electrode substrate for fuel cell. An impermeable material is used for edge sealant. The sealant is put in the clearance between two electrodes consisting of porous carbon material via thermoplastic resin sheet, and heated while being pressed. This production method increases the adherence between the porous carbon bodies and reduces the contact resistivity at the joint interface. Consequently, it becomes possible to produce the composite electrode for fuel cell without separator, resulting in simplification of assembly work, weight reduction, and downsizing. The preferable porous carbon body is made from shrinkage-treated fiber. After sheet forming, the thermosetting resin is impregnated, and then it is burnt to carbonization. Or mixed sheet of rayon and acrylic fiber is laminated to be heated and pressed without impregnating the resin. The pressed resin is then burnt to carbonization. The preferable ...

1996-04-12

284

Analysis of high turbulence combustion in a direct-injection diesel engine with high squish combustion chamber; CFD ni yoru ko squish nenshoshitsunai koranryu diesel nensho no kaiseki

The paper investigates the functional endoscopic sinus surgery with the Messer-linger's technique which treats benign or inflammatory diseases of paranasal sinuses resistant to medical therapy. The goal of this type of surgery is to open the obstructed sinus ostia and restore normal aeration and mucociliary clearance. The computerized tomography permits an accurate assessment of extension and results of functional endoscopic sinus surgery. [Italian] L'articolo discute l'uso della tecnica di Messerklinger nella chirurgia funzionale endoscopica dei seni paranasali per il trattamento delle malattie benigne e delle infiammazioni croniche. Essa disostruisce gli osti sinusali ripristinando la normale areazione e la pulizia mucociliare. La tomografia computerizzata consente di valutare l'estensione e i risultati del trattamento chirurgico funzionale, soprattutto nel caso di insuccesso terapeutico, rilevando malattia nasosinusale ...

1999-09-01

285

Trans-activation of the JC virus late promoter by the tat protein of type 1 human immunodeficiency virus in glial cells

Simultaneous reduction of NO{sub x} and particulate emissions in a direct-injection diesel engine has been realized experimentally with a high squish combustion chamber. The purpose of this study is to investigate the effects of high squish combustion chamber on combustion process in detail. Engine CFD code FREC was used for the analysis. The results show the followings. (1) Compared with standard toroidal chamber, high squish chamber generates high turbulence due to strong squish and large expansion flow is caused in the cavity. (2) Rich and high-turbulence combustion, which forms ring area in the cavity under squish lip, continues during the combustion. (3) The high squish combustion chamber keeps fuel long in the cavity and less hid spreads out to the cold clearance volume. (4) For the condition of retarded injection timing, the effect of high squish is mainly observed at initial combustion and high swirl is more effective at diffusion combustion. (author)

1999-08-25

286

Rearrangement of a common cellular DNA domain on chromosome 4 in human primary liver tumors

Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease of the central nervous system caused by the JC virus (JCV), a human papovavirus. PML is a relatively rare disease seen predominantly in immunocompromised individuals and is a frequent complication observed in AIDS patients. The significantly higher incidence of PML in AIDS patients than in other immunosuppressive disorders has suggested that the presence of human immunodeficiency virus type 1 (HIV-1) in the brain may directly or indirectly contribute to the pathogenesis of this disease. In the present study the authors have examined the expression of the JCV genome in both glial and non-glial cells in the presence of HIV-1 regulatory proteins. They find that the HIV-1-encoded trans-regulatory protein tat increases the basal activity of the JCV late promoter, JCV{sub L}, in glial cells. They conclude that the presence of the HIV-1-encoded tat protein may positively affect the JCV lytic cycle in glial cells by ...

1990-05-01

287

Rearrangement of a common cellular DNA domain on chromosome 4 in human primary liver tumors

Hepatitis B virus (HBV) DNA integration has been shown to occur frequently in human hepatocellular carcinomas. The authors have investigated whether common cellular DNA domains might be rearranged, possibly by HBV integration, in human primary liver tumors. Unique cellular DNA sequences adjacent to an HBV integration site were isolated from a patient with hepatitis B surface antigen-positive hepatocellular carcinoma. These probes detected rearrangement of this cellular region of chromosomal DNA in 3 of 50 additional primary liver tumors studied. Of these three tumor samples, two contained HBV DNA, without an apparent link between the viral DNA and the rearranged allele; HBV DNA sequences were not detected in the third tumor sample. By use of a panel of somatic cell hybrids, these unique cellular DNA sequences were shown to be located on chromosome 4. Therefore, this region of chromosomal DNA might be implicated in the formation of different tumors at one step of ...

1988-02-01

288

Organisms posses enzymes that function in the repair of DNA damaged by radiations, chemicals and metabolic events

Hepatitis B virus (HBV) DNA integration has been shown to occur frequently in human hepatocellular carcinomas. The authors have investigated whether common cellular DNA domains might be rearranged, possibly by HBV integration, in human primary liver tumors. Unique cellular DNA sequences adjacent to an HBV integration site were isolated from a patient with hepatitis B surface antigen-positive hepatocellular carcinoma. These probes detected rearrangement of this cellular region of chromosomal DNA in 3 of 50 additional primary liver tumors studied. Of these three tumor samples, two contained HBV DNA, without an apparent link between the viral DNA and the rearranged allele; HBV DNA sequences were not detected in the third tumor sample. By use of a panel of somatic cell hybrids, these unique cellular DNA sequences were shown to be located on chromosome 4. Therefore, this region of chromosomal DNA might be implicated in the formation of different tumors at one step of ...

289

Modulating factors in the expression of radiation-induced oncogenic transformation

This report briefly describes the studies on the mechanism of in vivo DNA repairing by the author in Research Reactor Institute, Kyoto Univ. for the past 30 years. First, the ability of UV radiation to induce transformation was investigated with viral DNA. The formation of thymine-thymine dimer was found harmful to organisms and such dimers were removable by UV-radiation at a low frequency. The mutability was determined in three different E.coli strains with mutator gene, mutT, mutS or mutL. The ability to excise 8-oxoguanin developed in primer DNA was deficient in mutT and miss-pairing left after DNA replication could not be recovered in mutL and mutS strains. Further, DNA repairing mechanism was investigated in other microorganisms; single-strand cleavage caused by exposure to BNCB radiation (boron-neutron-captured beam) could not be repaired in E. coli. Whereas for Deinococcus radiodurans, of which survival rate was not decreased by #gamma#-ray radiation at 5 ...

1998-01-01

290

Modulating factors in the expression of radiation-induced oncogenic transformation

Many assays for oncogenic transformation have been developed ranging from those in established rodent cell lines where morphological alteration is scored, to those in human cells growing in nude mice where tumor invasiveness is scored. In general, systems that are most quantitaive are also the least relevant in terms of human carcinogenesis and human risk estimation. The development of cell culture systems has made it possible to assess at the cellular level the oncogenic potential of a variety of chemical, physical and viral agents. Cell culture systems afford the opportunity to identify factors and conditions that may prevent or enhance cellular transformation by radiation and chemicals. Permissive and protective factors in radiation-induced transformation include thyroid hormone and the tumor promoter TPA that increase the transformation incidence for a given dose of radiation, and retinoids, selenium, vitamin E, and 5-aminobenzamide that inhibit the expression ...

1990-08-01

291

Human T-cell lymphotropic virus type III infection of the central nervous system: a preliminary in situ analysis

Many assays for oncogenic transformation have been developed ranging from those in established rodent cell lines where morphological alteration is scored, to those in human cells growing in nude mice where tumor invasiveness is scored. In general, systems that are most quantitaive are also the least relevant in terms of human carcinogenesis and human risk estimation. The development of cell culture systems has made it possible to assess at the cellular level the oncogenic potential of a variety of chemical, physical and viral agents. Cell culture systems afford the opportunity to identify factors and conditions that may prevent or enhance cellular transformation by radiation and chemicals. Permissive and protective factors in radiation-induced transformation include thyroid hormone and the tumor promoter TPA that increase the transformation incidence for a given dose of radiation, and retinoids, selenium, vitamin E, and 5-aminobenzamide that inhibit the expression ...

1990-01-01

292

GROWTH REGULATION IN ROUS SARCOMA VIRUS INFECTED CHICKEN EMBRYO FIBROBLASTS: THE ROLE OF THE src GENE

Patients with acquired immunodeficiency syndrome (AIDS) are subject to a spectrum of central nervous system (CNS) disorders. Recent evidence implicates the human T-cell lymphotropic virus type III (HTLV-III) in the pathogenesis of some of these illnesses, although the cells infected by the virus have yet to be identified. Using in situ hybridization, the authors examined brain tissue from two patients with AIDS encephalopathy for the presence of HTLV-III RNA. In both cases, viral RNA was detected and concentrated in, though not limited to, the white matter. The CNS cells most frequently infected included macrophages, pleomorphic microglia, and multinucleated giant cells. Less frequently, cells morphologically consistent with astrocytes, oligodendroglia, and rarely neurons were also infected. The findings strengthen the association of HTLV-III with the pathogenesis of AIDS encephalopathy. In situ hybridization can be applied to routinely prepared biopsy tissue in ...

1986-11-07

293

First report of the complete sequence of Sida golden yellow vein virus from Jamaica.

We report here a study of the mechanisms leading to loss of growth control in chicken embryo fibroblasts transformed by Rous sarcoma virus (RSV). We have been particularly concerned with the role of the src gene in this process, and have used RSV mutants temperature sensitive (ts) for transformation to investigate the nature of the growth regulatory lesion. The two principal findings were (1) the stationary phase of the cell cycle (G{sub 1}) in chick embryo fibroblasts seems to have two distinct regulatory compartments (using the terminology of Brooks et al. we refer to these as 'Q' and 'A' states). When rendered stationary at 41.5 C by serum deprivation, normal cells enter a Q state, but cells infected with the ts-mutant occupy an A state. (2) Whereas normal cells can occupy either state depending on culture conditions, the ts-infected cells, at 41.5 C, do not seem to enter Q even though a known src gene product, a kinase, is reported to be inactive ...

1980-07-01

294

An availability of brain magnetic resonance imaging (MRI) in the early diagnosis of latent hepatic encephalopathy

Begomoviruses are phytopathogens that threaten food security [18]. Sida spp. are ubiquitous weed species found in Jamaica. Sida samples were collected island-wide, DNA was extracted via a modified Dellaporta method, and the viral genome was amplified using degenerate and sequence-specific primers [2, 11]. The amplicons were cloned and sequenced. Sequence analysis revealed that a DNA-A molecule isolated from a plant in Liguanea, St. Andrew, was 90.9% similar to Sida golden yellow vein virus-[United States of America:Homestead:A11], making it a strain of SiGYVV. It was named Sida golden yellow vein virus-[Jamaica:Liguanea 2:2008] (SiGYVV-[JM:Lig2:08]). The cognate DNA-B, previously unreported, was successfully cloned and was most similar to that of Malvastrum yellow mosaic Jamaica virus (MaYMJV). Phylogenetic analysis suggested that this virus was most closely related to begomoviruses that infect malvaceous hosts in Jamaica, Cuba and Florida in the United States. ...

2011-05-29

295

A versatile and potentially general approach to the targeting of specific cell types by retroviruses: Application to the infection of human cells by means of major histocompatibility complex class I and class II antigens by mouse ecotropic murine leukemia virus-derived viruses

Brain MRI was carried out in patients with chronic liver diseases. No abnormal findings were recognized in patients with chronic viral hepatitis, while 59.2% of cirrhotics showed a symmetrically strong signal in basal ganglia on T1 weighted image in MRI. This finding significantly related with lowered Fischer`s ratio of serum amino acid, increased levels of serum phenylalanine, tyrosine and hyaluronic acid, prolonged prothrombin time and decreased platelet counts in the peripheral blood. Overt hepatic encephalopathy was observed in 6 of 34 patients with the strong signal in MRI during follow-up period, while none of patients without that finding developed hepatic encephalopathy. These results have indicated that the strong signal in basal ganglia on MRI appears in cirrhotic patients with severe liver dysfunction, and it is an useful index in the early diagnosis of latent hepatic encephalopathy. An improvement of this MRI finding was not observed by long-term oral ...

1996-03-01

296

In vitro and in vivo analysis of pegulated Avidin

A technique for delivering genes carried by recombinant retroviruses into specific cell types could have numerous applications in oncology, developmental biology, and gene therapy. As a first step toward this remote goal the authors designed a procedure allowing in vitro cell targeting by retroviruses. Biotinylated antibodies against the viral envelope protein on one side, and against specific cell membrane markers on the other side, were bridged by streptavidin and used to link the virus to the host. The method was successfully used to infect human cells with ecotropic murine retroviruses by means of major histocompatibility complex class I and class II antigens and appears easily adaptable to other cell, membrane markers. Moreover, the sequential protocol they design, although allowing infection of human cells, requires less stringent safety constraints than would handling of amphotropic virus stocks.

1989-12-01

297

The effects of temperature dependent viscosity and thermal conductivity on unsteady MHD convective heat transfer past a semi-infinite vertical porous moving plate with variable suction

Full text: In 1995, we demonstrated the use of pretargetting three steps method and biotinylated tetracycline using radiolabelled {sup 99m}Tc-DTPA-biocytinamide for the detection of tumour cells in (C57B1/6 x BALB/C) F1 mice with E-3 thymoma. The three steps were (1) IP injection of biotinylated-tetracycline conjugate (1:1) ratio, (2) 96 hours later Avidin/Streptavidin was injected, and (3) 24 hours after (2), {sup 99m}Tc-biocytinamide -cDTPA was injected. Mice were sacrificed 16/24 h after (3) by cervical dislocation. Biodistribution of radioactivity tumour to blood, liver, bone were T:B1= 15.0, T:Li= 5.08, T:Bo=15.0. The percentage of injected dose per g was T= 3.15% and B1= 0.21%. To prolong circulation of Avidin and therefore its uptake into tumour, Avidin was covalently bound to polyethylene-glycol (PEG20 KD) at the molar ratio of PEG:Avidin 100:1 and 400:1. The pegulated Avidin was then cleared from the circulation using Dextran-70-Biotin. The distribution and binding were ...

1997-09-01

298

British Library Electronic Table of Contents (United Kingdom)

In this article, we studied the effects of variable viscosity and thermal conductivity on an unsteady two-dimensional laminar flow of a viscous incompressible conducting fluid past a semi-infinite vertical porous moving plate taking into account the effect of a magnetic field in the presence of variable suction. The fluid viscosity is assumed to vary as an inverse linear function of temperature but the thermal conductivity is assumed to vary as a linear function of temperature. It is assumed that the porous plate moves with a constant velocity in the direction of fluid flow, and the free stream velocity follows the exponentially increasing small perturbation law. The governing equations for the flow are transformed into a system of nonlinear ordinary differential equations by perturbation ...

2007-01-01

299

The coexistence of fish species in streams: relationships between assemblage attributes and trophic and environmental variables

British Library Electronic Table of Contents (United Kingdom)

Diet overlap and niche breadth are well-known species traits from trophic ecology that can assist in explaining how species interact and coexist as well as the ecological mechanisms that influence biodiversity. In the present study, we analyzed the relationships between these trophic variables and indicators of resource availability with some attributes of fish assemblages (species richness, Shannon diversity index, evenness, density and individual body size). The physical and chemical characteristics of the biotopes (topography, water quality and conservation of slopes) were examined to identify possible patterns. Monthly sampling using electrofishing was conducted in 2003 along five streams located in the Cuiab? River watershed. The relationships between environmental variables and attri...

2011-01-01

300

Powertrain and apparatus using a continuously variable ratio transmission to improve fuel economy

Power correlation for vertical axis wind turbines with varying geometries

An automotive powertrain includes a conventional piston engine, a continuously variable ratio transmission, an engine speed sensor and a feedback control system. The control system adjusts both the transmission ratio and the throttle valve in the engine carburetor or fuel metering system in response to the position of the accelerator pedal and in response to the crankshaft speed as measured by the engine sensor. The transmission provides extreme overdrive gear ratios which allow the engine to be operated at wide open throttle even during moderate cruising, and, in addition, the engine carburetor or fuel metering system is calibrated to deliver to the engine a stoichiometric air-fuel mixture which is combined, before combustion, with a special proportion of recirculated exhaust gas. As a result of extensive wide open throttle engine operation with the above mentioned intake charge composition, combustion variables are optimized to produce ...

1981-07-28

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301

British Library Electronic Table of Contents (United Kingdom)

Abstract In this paper, a new predictive model that can forecast the performance of a vertical axis wind turbine (VAWT) is presented. The new model includes four primary variables (rotor velocity, wind velocity, air density, and turbine power output) as well as five geometrical variables (rotor radius, turbine height, turbine width, stator spacing, and stator angle). These variables are reduced to include the power coefficient (Cp) and tip speed ratio (TSR). A power coefficient correlation for a novel VAWT (called a Zephyr Vertical axis Wind Turbine (ZVWT)) is developed. The turbine is an adaptation of the Savonius design. The new correlation can predict the turbine's performance for altered stator geometry and varying operating conditions. Numerical simulations with a rotating reference f...

2011-01-01

302

Long and Short Distance Migration in Italy: The Role of Economic, Social and Environmental Characteristics

British Library Electronic Table of Contents (United Kingdom)

This paper analyses Italian interregional migration flows. The approach taken is to decompose labour mobility flows into short distance and long distance migration and to model the effects of economic variables, social capital and quality of life variables, and amenity variables, on the mobility behaviour of individuals. We estimate these different types of migration flows using a negative binomial model, augmented with instruments to control for potential endogeneity issues. Our findings demonstrate that long distance migration reflects a disequilibrium model of migration whereas short distance migration largely reflects an equilibrium model of migration. As such, attempts to model interregional migration in general will be mis-specified as the simultaneously-operating underlying mobility...

2011-01-01

303

Irreversible Performance of a Quantum Harmonic Heat Engine

Interannual relationships between Indian Summer Monsoon and Indo-Pacific coupled modes of variability during recent decades

The unavoidable irreversible losses of power in a heat engine are found to be of quantum origin. Following thermodynamic tradition a model quantum heat engine operating by the Otto cycle is analyzed. The working medium of the model is composed of an ensemble of harmonic oscillators. A link is established between the quantum observables and thermodynamical variables based on the concept of canonical invariance. These quantum variables are sufficient to determine the state of the system and with it all thermodynamical variables. Conditions for optimal work, power and entropy production show that maximum power is a compromise between the quasistatic limit of adiabatic following on the compression and expansion branches and a sudden limit of very short time allocation to these branches. At high temperatures and quasistatic operating conditions the efficiency at maximum power coincides with the endoreversible result. The optimal ...

2006-01-01

304

British Library Electronic Table of Contents (United Kingdom)

Various SST indices in the Indo-Pacific region have been proposed in the literature in light of a long-range seasonal forecasting of the Indian Summer Monsoon (ISM). However, the dynamics associated with these different indices have never been compared in detail. To this end, the present work re-examines the variabilities of ISM rainfall, onset and withdrawal dates at interannual timescales and explores their relationships with El Ni?o-Southern Oscillation (ENSO) and various modes of coupled variability in the Indian Ocean. Based on recent findings in the literature, five SST indices are considered here: Ni?o3.4 SST index in December?January both preceding [Nino(?1)] and following the ISM [Nino(0)], South East Indian Ocean (SEIO) SST in February?March, the Indian Ocean Basin (IOB) mode in ...

2011-01-01

305

Experiences in batch trajectory alignment for pharmaceutical process improvement through multivariate latent variable modelling

British Library Electronic Table of Contents (United Kingdom)

The primary objective of batch data as trajectory alignment (or synchronization) is to standardize the data sampling per batch according to the evolution of the process, and secondarily to homogenize the samples per run. The use of an indicator variable performs both objectives well. Two examples from the pharmaceutical sector are discussed to illustrate the different ways to deal with uneven samples across batches and across variables in the same batch. Since trajectory alignment requires large time investment, a simple triage approach is proposed to assess the need to analyze the dynamics of a given process and hence perform alignment. The presented examples are representative of a broad variety of batch processes that are operated by recipe in the pharmaceutical sector. In our experienc...

2011-01-01

306

Enamel-Calibrated Lamellar Bone Reveals Long Period Growth Rate Variability in Humans

British Library Electronic Table of Contents (United Kingdom)

Abstract Mammalian teeth exhibit incremental structures representing successive forming fronts of enamel at varying time scales, including a short daily increment called a cross striation and a long period called a stria of Retzius, the latter of which, in humans, occurs on average every 8-9 days. The number of daily increments between striae is called the repeat interval, which is the same period as that required to form one increment of bone, i.e. the lamella, the fundamental - if not archetypal - unit of bone. Lamellae of known formation time nevertheless vary in width, and thus their measures provide time-calibrated growth rate variability. We measured growth rate variability for as many as 6 years of continuously forming primary incremental lamellar bone from midshaft femur histologic...

2011-01-01

307

Dirichlet mean identities and laws of a class of subordinators

Combined inverse modeling approach and load duration curve method for variable nitrogen total maximum daily load development in an agricultural watershed

An interesting line of research is the investigation of the laws of random variables known as Dirichlet means. However, there is not much information on interrelationships between different Dirichlet means. Here, we introduce two distributional operations, one of which consists of multiplying a mean functional by an independent beta random variable, the other being an operation involving an exponential change of measure. These operations identify relationships between different means and their densities. This allows one to use the often considerable analytic work on obtaining results for one Dirichlet mean to obtain results for an entire family of otherwise seemingly unrelated Dirichlet means. Additionally, it allows one to obtain explicit densities for the related class of random variables that have generalized gamma convolution distributions and the finite-dimensional distribution of their associated L\\'{e}vy processes. ...

2010-01-01

308

British Library Electronic Table of Contents (United Kingdom)

Purpose Nonpoint sources (NPS) pollution has been an important cause for water quality impairment worldwide. To take the temporal variations of both NPS pollution and in-stream attenuation into consideration, an inverse modeling approach and the load duration curve (LDC) method were combined for variable nutrient total maximum daily load (TMDL) development. Methods Water quality and hydrological parameters were monitored monthly along the ChangLe River system in 2004?2008. The catchment NPS export load (EL) and TMDL for total nitrogen (TN) were estimated by the inverse format of an existing stream nutrient transport equation. The LDC method was used to describe the variability of EL, TMDL, requiring load (RLR) and percent (the ratio between the RLR and the EL, RPR) reduction, and then to s...

2011-01-01

309

Characterizing the time variability in magnetized neutrino--cooled accretion disks: signatures of the gamma-ray burst central engine

Centennial climate variability in the British Isles during the mid-late Holocene

The central engine of Gamma Ray Bursts is hidden from direct probing with photons mainly due to the high densities involved. Inferences on their properties are thus made from their cosmological setting, energetics, low-energy counterparts and variability. If GRBs are powered by hypercritical accretion onto compact objects, on small spatial scales the flow will exhibit fluctuations, which could in principle be reflected in the power output of the central engine and ultimately in the high energy prompt emission. Here we address this issue by characterizing the variability in neutrino cooled accretion flows through local shearing box simulations with magnetic fields, and then convolving them on a global scale with large scale dynamical simulations of accretion disks. The resulting signature is characteristic, and sensitive to the details of the cooling mechanism, providing in principle a discriminant for GRB central engine properties.

2010-01-01

310

British Library Electronic Table of Contents (United Kingdom)

Multi-millennial climate changes were relatively minor over the mid-late Holocene in the British Isles, because orbitally forced insolation changes were smaller than those at higher latitudes. Centennial climate variability is thus likely to have exerted a greater influence on the environment and human society of the region. Proxy-climate records from the British Isles covering the last 4500years are assembled and re-evaluated with the aim of identifying centennial climate variability reflected by multi-proxy indicators. The proxies include bog oak populations, peatland surface wetness, flooding episodes from fluvial deposits, speleothem annual band width and oxygen isotopes, chironomids from lake sediments and sand and dune deposition. Most proxies reflect water balance rather than temper...

2010-01-01

311

Assessing variability of water quality in a groundwater-fed perennial lake of Kashmir Himalayas using linear geostatistics

British Library Electronic Table of Contents (United Kingdom)

This paper presents a study on Manasbal lake, which is one of the high altitude lakes in the Kashmir Valley, India. Eighteen water samples were analysed for major ions and trace elements to assess the variability of water quality of the lake for various purposes. Geostatistics, the theory of regionalized variables, was then used to enhance the dataset and estimate some missing spatial values. Results indicated that the concentration of major ions in the water samples in winter was higher than in summer. The scatter diagrams suggested the dominance of alkaline earths over the alkali elements. Three types of water were identified in the lake that are referred to as Ca?HCO3, Mg?HCO3 and hybrid types. The lake water was found to be controlled by rock?water interaction with carbonate lithology ...

2011-01-01

312

Advanced experimental design applied to damage tolerance of composite materials

A variable gene delivery carrier-biotinylated chitosan/polyethyleneimine

This paper focuses on a factorial-based design strategy. The approach provides an efficient and statistically reliable means for assessing the influence of multivariable effects. It is applied to the detection and evaluation of damage in impacted composite sandwich panels. The experimental results obtained from this test strategy are utilized to form an empirical response function. The resulting polynomial relates damage area to residual compression strength at values of independent variables for which testing did not occur. The response function also identifies nonlinear interaction effects of key variabes that cannot be easily ascertained by traditional single-variable test strategies. Independent variables evaluated include core thickness, number of face sheet plys and impact energy. The methodology presented allows the designer to predict with more confidence the damage tolerance of a composite material component, and ...

1991-01-01

313

A study on the pretreatment of a sugarcane bagasse sample with dilute sulfuric acid

A variable gene delivery system has been developed based on conjugating chitosan to biotin through a functionalized poly(ethylene glycol) (PEG) spacer, which can be used to further bind different molecules on the outer layer of a polymer/DNA complex by streptavidin (SA)-biotin linkage. In this study, TAT-conjugated SA was used as the model molecule to prove the conjugation function of the prepared complex. In addition, low-molecular-weight poly(ethyleneimine) (PEI) was added into the polymer/DNA complex to increase the transfection efficiency. The results of the luciferase assay show that the transfection efficiency of the prepared complex was significantly correlated with the amount of PEI and was further enhanced when TAT was conjugated to the complex by SA-biotin linkage. Considered to have negligible cytotoxic effects, the variable gene delivery complex prepared in this study would be of considerable potential as carriers for in vitro ...

2010-12-01

314

British Library Electronic Table of Contents (United Kingdom)

Experiments based on a 23 central composite full factorial design were carried out in 200-ml stainless-steel containers to study the pretreatment, with dilute sulfuric acid, of a sugarcane bagasse sample obtained from a local sugar?alcohol mill. The independent variables selected for study were temperature, varied from 112.5?C to 157.5?C, residence time, varied from 5.0 to 35.0 min, and sulfuric acid concentration, varied from 0.0% to 3.0% (w/v). Bagasse loading of 15% (w/w) was used in all experiments. Statistical analysis of the experimental results showed that all three independent variables significantly influenced the response variables, namely the bagasse solubilization, efficiency of xylose recovery in the hemicellulosic hydrolysate, efficiency of cellulose enzymatic saccharificatio...

2011-01-01

315

Water Deficit and Spatial Pattern of Leaf Development. Variability in Responses Can Be Simulated Using a Simple Model of Leaf Development1

Variable domain I of nematode CLEs directs post-translational targeting of CLE peptides to the extracellular space

We analyzed the effect of short-term water deficits at different periods of sunflower (Helianthus annuus L.) leaf development on the spatial and temporal patterns of tissue expansion...Full Text Available

1999-02-01

316

Transposable elements are enriched within or in close proximity to xenobiotic-metabolizing cytochrome P450 genes

Effector proteins expressed in the esophageal gland cells of cyst nematodes are delivered into plant cells through a hollow, protrusible stylet. Although evidence indicates that effector proteins function...Full Text Available

2010-12-01

317

Transport of sorbing solutes in randomly heterogeneous formations: Spatial moments, macrodispersion, and parameter uncertainty

BackgroundTransposons, i.e. transposable elements (TEs), are the major internal spontaneous mutation agents for the variability of eukaryotic genomes. To address the general issue...Full Text Available

318

Time-Referenced Effects of an Internal vs. External Focus of Attention on Muscular Activity and Compensatory Variability

Expressions for the spatial moments and macrodispersion tensor for sorbing solutes in heterogeneous formations were presented using a probabilistic model of a fluid residence time coupled with the particle position analysis. The fluid residence time was defined as a fraction of the actual time during which the particle stayed in the mobile fluid phase of the aquifer. The fluid residence time is a random variable whose variability comes as a result of the non-equilibrium sorption properties. The sorbing solute was assumed to be governed with first-order linear kinetics. The closed-form expressions were based on the stationarity in the kinetic process and on the first-order approximation in the hydraulic conductivity field and in the fluid residence time. The non-equilibrium effects were presented as a function of the spatial variability in hydraulic conductivity and temporal variability in the fluid ...

1993-06-01

319

The Interaction between AID and CIB1 Is Nonessential for Antibody Gene Diversification by Gene Conversion or Class Switch Recombination

The paralysis-by-analysis phenomenon, i.e., attending to the execution of one's movement impairs performance, has gathered a lot of attention over recent years (see Wulf, 2007,...Full Text Available

320

Temporal Stability of Urinary and Plasma Biomarkers of Tobacco Smoke Exposure among Cigarette Smokers

Activation-induced deaminase (AID) initiates somatic hypermutation, gene conversion and class switch recombination by deaminating variable and switch region DNA cytidines to uridines. AID is predominantly...Full Text Available

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321

Seasonal and Spatial Variability of Bacterial and Archaeal Assemblages in the Coastal Waters near Anvers Island, Antarctica

Intraindividual variability of measurements of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL), nicotine, cotinine, and r-1,t-2,3,c-4-tetrahydroxy-1,2,3,4-tetrahydrophenanthrene...Full Text Available

2010-06-01

322

Relationship between mRNA secondary structure and sequence variability in Chloroplast genes: possible life history implications

A previous report of high levels of members of the domain Archaea in Antarctic coastal waters prompted us to investigate the ecology of Antarctic planktonic prokaryotes. rRNA hybridization...Full Text Available

1998-07-01

323

RESPONSE LATENCY AS AN INDEX OF RESPONSE STRENGTH DURING FUNCTIONAL ANALYSES OF PROBLEM BEHAVIOR

BackgroundSynonymous sites are freer to vary because of redundancy in genetic code. Messenger RNA secondary structure restricts this freedom, as revealed by previous findings in...Full Text Available

324

QOI10/477: The medCERTAIN Project: Rating and certification of Internet health information using medPICS

Dependent variables in research on problem behavior typically are based on measures of response repetition, but these measures may be problematic when behavior poses high risk or when its occurrence...Full Text Available

2011-01-01

325

Predictors of disability in a longitudinal sample of patients with rheumatoid arthritis.

IntroductionHealth information on the Internet undergoes no quality control at the stage of production, thus its quality is highly variable, making it difficult...Full Text Available

326

Practical Applications of the Bioinformatics Toolbox for Narrowing Quantitative Trait Loci

Information from the Health Assessment Questionnaire (HAQ) is used to identify which variables measured in 1981 successfully predict the severity of disease in 1989 and the eight year change in severity...Full Text Available

1992-05-01

327

Post traumatic stress symptoms and heart rate variability in Bihar flood survivors following yoga: a randomized controlled study

Dissecting the genes involved in complex traits can be confounded by multiple factors, including extensive epistatic interactions among genes, the involvement of epigenetic regulators, and the variable...Full Text Available

2008-12-01

328

OPTIMIZATION OF COMBINED SEWER OVERFLOW CONTROL SYSTEMS

BackgroundAn earlier study showed that a week of yoga practice was useful in stress management after a natural calamity. Due to heavy rain and a rift on the banks of the Kosi river,...Full Text Available

329

Non-Detection of Polarized, Scattered Light from the HD 189733b Hot Jupiter

The highly variable and intermittent pollutant concentrations and flowrates associated with wet-weather events in combined sewersheds necessitates the use of storage-treatment systems to control pollution.An optimized combined-sewer-overflow (CSO) control system requires a manage...

330

Monitoring the Simultaneous Presentation of Spatialized Speech Signals in a Virtual Acoustic Environment.

Using the POLISH instrument, I am unable to reproduce the large-amplitude polarimetric observations of Berdyugina et al. (2008) to the >99.99% confidence level. I observe no significant polarimetric variability in the HD 189733 system, and the upper limit to variability from the exoplanet is Delta_P < 7.9 x 10^(-5) with 99% confidence in the 400 nm to 675 nm wavelength range. Berdyugina et al. (2008) report polarized, scattered light from the atmosphere of the HD 189733b hot Jupiter with an amplitude of two parts in 10^4. Such a large amplitude is over an order of magnitude larger than expected given a geometric albedo similar to other hot Jupiters. However, my non-detection of polarimetric variability phase-locked to the orbital period of the exoplanet, and the lack of any significant variability, shows that the polarimetric modulation reported by Berdyugina et al. (2008) cannot be due to the ...

2009-01-01

331

Molecular dynamics of a ?B DNA element: base flipping via cross-strand intercalative stacking in a microsecond-scale simulation

The effect of spatial auditory information on a listener's ability to detect, identify, and monitor multiple simultaneous speech signals was evaluated using virtual audio technology. Factorial combinations of three variables - the number of localized spee...

1998-01-01

332

Molecular Variability of Pseudallescheria boydii, a Neurotropic Opportunist

The sequence-dependent structural variability and conformational dynamics of DNA play pivotal roles in many biological milieus, such as in the site-specific binding of transcription factors to target...Full Text Available

2008-09-01

333

Lymphoma depletion during CD20 immunotherapy in mice is mediated by macrophage Fc?RI, Fc?RIII, and Fc?RIV

The sequences of the internal transcribed spacer (ITS) ribosomal DNA (rDNA) domain data obtained by restriction fragment length polymorphism analysis with 18S rDNA and fingerprinting (M13) for clinical...Full Text Available

2000-09-01

334

Investigating the spatial variability in incidence of coronary heart disease in the Gazel cohort: the impact of area socioeconomic position and mediating role of risk factors

Despite the demonstrated clinical efficacy of CD20 monoclonal antibody (mAb) for lymphoma therapy, the in vivo mechanisms of tumor depletion remain controversial and variable. To identify the molecular...Full Text Available

2008-08-15

335

Industrial emissions cause extreme urban ozone diurnal variability

Study objectiveThe study aim was to improve our understanding of the relationships between contextual socioeconomic characteristics and coronary heart disease (CHD)...Full Text Available

2011-02-01

336

Incorporation of the International Spinal Cord Injury Data Set Elements into the National Institute of Neurological Disorders and Stroke (NINDS) Common Data Elements (CDEs)

Simulations with a regional chemical transport model show that anthropogenic emissions of volatile organic compounds and nitrogen oxides (NO_x = NO + NO₂) lead to a dramatic diurnal...Full Text Available

2004-04-27

337

Identification of genes and haplotypes that predict rheumatoid arthritis using random forests

ObjectiveTo develop consistent variable names and a common database structure for the data elements in the International Spinal Cord Injury (SCI) Data Sets.Full Text Available

2011-01-01

338

Human variability and susceptibility to trichloroethylene.

Random forest (RF) analysis of genetic data does not require specification of the mode of inheritance, and provides measures of variable importance that incorporate interaction effects. In this paper...Full Text Available

339

Hominin life history: reconstruction and evolution

Although humans vary in their response to chemicals, comprehensive measures of susceptibility have generally not been incorporated into human risk assessment. The U.S. EPA dose-response-based risk assessments...Full Text Available

2000-05-01

340

High genetic variability and low local diversity in a population of arbuscular mycorrhizal fungi

In this review we attempt to reconstruct the evolutionary history of hominin life history from extant and fossil evidence. We utilize demographic life history theory and distinguish life history variables,...Full Text Available

2008-04-01

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341

High Speed Cylindrical Roller Bearing Development.

Arbuscular mycorrhizal fungi (AMF) are ecologically important root symbionts of most terrestrial plants. Ecological studies of AMF have concentrated on differences between species; largely assuming...Full Text Available

2004-02-24

342

Heats (enthalpies) of formation of coals and the thermodynamic evaluation of the coal formation process

High speed experimental tests provided data on six parametric cylindrical roller bearings. Four bearing variables were evaluated and the results were correlated with the analytical model developed under Naval Air Propulsion Center Contract N00140-76-C-038...

1980-01-01

343

British Library Electronic Table of Contents (United Kingdom)

An approach to the calculation of the quantity of heat consumed in the process of coal formation is presented. The variability of this parameter in a coalification series is analyzed using coals from the Kuznetsk and Tunguska Basins as an example.

2011-01-01

344

Hamiltonian BRST formalism for gauge-invariant systems with closed algebra

Glossitis of Military Workingn> Dogs in South Vietnam: History and Clinical Characteristics.

The systems for which the algebra of gauge transformations in the lagrangian formalism is closed, are considered. The hamiltonian BRST charge and the BRST-invariant hamiltonian are found explicitly. Their expansions in powers of the ghost variables contain, in general, an infinite number of terms. (orig.).

1991-11-01

345

Genome-wide linkage scan for contraction velocity characteristics of knee musculature in the Leuven Genes for Muscular Strength Study

Glossitis among U.S. military working dogs in South Vietnam was characterized by variable redness and loss of papillae on the anterodorsal third of the tongue; salivation, drooling, and inappetence were the principal clinical signs. Symptomatic treatment ...

1973-01-01

346

Genome size and wing parameters in passerine birds

The torque-velocity relationship is known to be affected by ageing, decreasing its protective role in the prevention of falls. Interindividual variability in this torque-velocity relationship is partly...Full Text Available

2008-09-01

347

Genetic architecture of voluntary exercise in an advanced intercross line of mice

Despite their status as the most speciose group of terrestrial vertebrates, birds exhibit the smallest and least variable genome sizes among tetrapods. It has been suggested that this is because powered...Full Text Available

2009-01-07

348

Feature Selection and Classification of MAQC-II Breast Cancer and Multiple Myeloma Microarray Gene Expression Data

Exercise is essential for health, yet the amount, duration, and intensity that individuals engage in are strikingly variable, even under prescription. Our focus was to identify the locations and effects...Full Text Available

2010-07-01

349

Experimental evaluation of angularly-variable fiber geometry for targeting depth-resolved reflectance from layered epithelial tissue phantoms

Microarray data has a high dimension of variables but available datasets usually have only a small number of samples, thereby making the study of such datasets interesting and challenging. In the task...Full Text Available

350

Effect of Wastewater Treatment Plant Effluent on Microbial Function and Community Structure in the Sediment of a Freshwater Stream with Variable Seasonal Flow?

The aim of the present study focuses on experimentally demonstrating the efficacy of using angularly-variable fiber geometry to achieve the desired tissue-layer selection and probing depths with the further objective of enhancing the sensitivity and specificity of spectral diagnosis in stratified architectures that resemble human cervical epithelia. The morphological and biochemical features of epithelial tissue vary in accordance with tissue depths; consequently, the accuracy of spectroscopic diagnosis of epithelial dysplasia may be enhanced by probing the optical properties of this tissue. When correlated to cellular dysplasia, layer-specific changes in tissue optical properties may be deciphered by reflectance spectroscopy coupled with angularly-variable fiber geometry. This study addresses the utility of using such angularly-variable fiber geometry for resolving spatially-specific spectral signatures of tissue ...

2007-03-01

351

EFFECT OF THE DIGENEAN PARASITE PROTEROMETRA MACROSTOMA ON HOST MORPHOLOGY IN THE FRESHWATER SNAIL ELIMIA LIVESCENS

We investigated the effects of wastewater treatment plant (WWTP) discharge on the ecology of bacterial communities in the sediment of a small, low-gradient stream in South Australia. The quantification...Full Text Available

2008-05-01

352

Do the Obese Have Lower Body Temperatures? A New Look at a Forgotten Variable in Energy Balance

... 1984; Martin-Mora et al., 1995), and parasitism (Rothschild and Rothschild, 1939; Pesigan et al., 1958; Moose, 1963; Pan, ... effects of digeneans are variable; they may enhance (Rothschild and Rothschild...

353

Dimensionless energy confinement scaling in W7-AS

Understanding the pathogenesis of obesity is now more important than ever, given the remarkable world-wide epidemic. This paper explores the potential role of core temperature in energy balance, and...Full Text Available

2009-01-01

354

Detrended Fluctuation Analysis of Intracranial Pressure Predicts Outcome Following Traumatic Brain Injury

Energy confinement in W7-AS has been analyzed in terms of dimensionally exact form free functions employing Bayesian probability theory. The confinement function was set up as a linear combination of dimensionally exact power law terms as already proposed very early by Connor and Taylor. Generation of this expansion basis is dictated by the basic plasma model which one assumes. Based upon data accumulated in W7-AS, which contains the energy content for a wide variety of variable settings, predictions for single variable scans are made. The scaling functions for density and power scans, respectively, are in quantitative agreement with data collected in W7-AS. The result of a single variable scan is therefore already hidden in the data obtained for arbitrary variable choices and can be extracted from the latter by a proper data analysis. Furthermore, the optimal model for the description of the global ...

1999-12-01

355

Determinants of output in group and solo medical practice.

Detrended fluctuation analysis (DFA) is a recently developed technique suitable for describing scaling behavior of variability in physiological signals. The purpose of this study is to explore...Full Text Available

2008-11-01

356

Determinants of health insurance ownership among South African women

Certain structural and environmental factors other than technical combination of resources and firm size are hypothesized to affect medical practice output. Four groups of variables related to physician...Full Text Available

1976-01-01

357

Climate models and scenarios

BackgroundStudies conducted in developed countries using economic models show that individual- and household- level variables are important determinants of health insurance ownership....Full Text Available

358

Cangrelor increases the magnitude of platelet inhibition and reduces interindividual variability in clopidogrel-pretreated subjects

In recent years the modelling of interannual climate variability has been studied, the atmospheric energy and water cycles, and climate simulations with the ECHAM3 model. In addition, the climate simulations of several models have been compared with special emphasis in the area of northern Europe

1996-12-31

359

Calibration of the solar UV radiometers in Finland

BackgroundInadequate platelet inhibition despite aspirin and clopidogrel therapy during and after a percutaneous coronary intervention is associated with an impaired clinical outcome....Full Text Available

2009-05-01

360

CYP1B1 mutations in Spanish patients with primary congenital glaucoma: phenotypic and functional variability

In this report, the main emphasis is given to (1) the problems associated with the basic calibration of the spectroradiometer and (2) the year-to-year variability of the calibrations of the solar UV network radiometers. Also, the results from intercomparisons of the Brewer and OL 742 spectroradiometers are included

1996-12-31

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

361

Boundary value problem for an elliptic equation with rapidly oscillating coefficients in a rectangle

PurposeTo analyze the contributions of cytochrome P4501B1 (CYP1B1) mutations to primary congenital glaucoma (PCG) in Spanish patients.MethodsWe...Full Text Available

362

British Library Electronic Table of Contents (United Kingdom)

An elliptic equation in a rectangle with coefficients depending on a fast variable and with its period being a small parameter is considered. An asymptotic expansion of the solution up to an arbitrary degree of the small parameter is constructed and substantiated by applying the two-scale expansion method.

2011-01-01

363

Average uncertainty as a determinant of observing behavior1

Automatic stenosis detection and quantification in renal arteriography.

After discrimination training on a multiple variable-interval extinction schedule of food reinforcement, pigeons were placed on the uncued or mixed version of the same schedule and allowed to make...Full Text Available

1974-09-01

364

Assessing spatio-temporal variability of risk surfaces using residential history data in a case control study of breast cancer

Visual assessment of the degree of renal artery stenosis on renal arteriography has a large inter- and intraobserver variability. This degree is usually estimated by the ratio between the most narrowed...Full Text Available

1997-01-01

365

Aspirin and Clopidogrel Response Variability

BackgroundMost analyses of spatial clustering of disease have been based on either residence at the time of diagnosis or current residence. An underlying assumption in these analyses...Full Text Available

366

Analytical study on analysis methods of several random variables for seismic nonlinear responses of reactor buildings

Antiplatelet resistance has been proposed as a possible mechanism to explain recurrent cardiovascular events in patients who have coronary artery disease and who are undergoing dual antiplatelet therapy....Full Text Available

2008-01-01

367

Absolute CD4+ T-Lymphocyte Count as a Surrogate Marker of Pediatric HIV Disease Progression

In the case wherein nonlinear seismic response analyses are carried out, the response values vary due to the variations in materials and modeling. In this paper, nonlinear analyses of several random variables are carried out using: i. a conventional method; ii. a two-point estimation method (i. and ii. are simplified methods); and iii. Monte Carlo simulation (detailed method) to examine the variability of the response in the excessive nonlinear range for seismic responses of shear walls. The analyses are performed to a PWR-3 loop type reactor building which is one of the most typical reactor buildings in Japan. The variations are considered in specified compressive strength of concrete, concrete damping factor, shear wave velocity of soil and shapes of shear stress-strain relation curves of shear walls. As the results by the two simplified methods closely matched the Monte Carlo simulation results, the appropriateness for applying the ...

1993-08-15

368

A new evolutionary scenario for the Mycobacterium tuberculosis complex

BackgroundTraditionally in pediatric HIV, the CD4+ T-lymphocyte percent is used in monitoring disease progression due to the variability in absolute CD4+ T-lymphocyte...Full Text Available

2008-07-01

369

A new VCAN/versican splice acceptor site mutation in a French Wagner family associated with vascular and inflammatory ocular features

The distribution of 20 variable regions resulting from insertion-deletion events in the genomes of the tubercle bacilli has been evaluated in a total of 100 strains of Mycobacterium tuberculosis,...Full Text Available

2002-03-19

370

A Latent Variable Approach for Meta-Analysis of Gene Expression Data from Multiple Microarray Experiments

PurposeTo detail the highly variable ocular phenotypes of a French family affected with an autosomal dominantly inherited vitreoretinopathy and to identify the disease gene.MethodsSixteen...Full Text Available

371

A Computational Framework Discovers New Copy Number Variants with Functional Importance

BackgroundWith the explosion in data generated using microarray technology by different investigators working on similar experiments, it is of interest to combine results across...Full Text Available

372

Variable-dispersion electron spectrometer for the SCA/FEL

Structural variants which cause changes in copy numbers constitute an important component of genomic variability. They account for 0.7% of genomic differences in two individual genomes, of which...Full Text Available

373

United States Air Force Academy (USAFA) Vertical Axis Wind Turbine. Final report May 77-Sep 80

A variable-dispersion electron spectrometer is being installed for use by the Stanford Superconducting Accelerator in conjunction with its Free Electron Laser program. The system has been designed to operate with electron beam energies from 20 MeV to 200 MeV, with a maximum energy resolution of 0.01% FWHM. The maximum energy acceptance is approximately #+-# 5%, as determined by the bending magnet aperture. Resolution is controlled by adjusting the focal conditions at the entrance to a 90 degree bending magnet, while the dispersion is controlled by changing the magnitude and polarity of the field in a quadrupole magnet which immediately follows the bending magnet. 4 refs., 5 figs.

1989-06-01

374

The effects of aircraft engine pollutant emission measurement variability on engine certification policy

This report describes the design, fabrication, installation and testing of a small variable-speed vertical axis wind turbine (VAWT). This VAWT is unique in its installation using hand tools only; unconventional and simple support system; and variable speed operation under microprocessor control. Initial testing confirmed that the turbine can be controlled by commanded alternator field modulation. Further studies will be directed toward determination of an optimum control algorithm.

1980-09-01

375

Separation of variables for the quantum SL(2,R) spin chain

Divergence between aircraft engine emission regulations proposed by EPA and ICAO is discussed. Every engine, upon entering service, requires a certificate as to its compliance with emission standards. It is shown that despite the large variability in the measurements, it is possible to devise a certification procedure requiring the testing of one engine only. Statistical modeling of such a test at the 5% significance level is described. Values of the parameter standard deviation/mean recommended as certification standards for various pollutants are given. Features of a rational certification scheme to be formulated are outlined.

1978-10-01

376

Product identification in industrial batch fermentation using a variable forgetting factor

We construct representation of the Separated Variables (SoV) for the quantum SL(2,R) Heisenberg closed spin chain and obtain the integral representation for the eigenfunctions of the model. We calculate explicitly the Sklyanin measure defining the scalar product in the SoV representation and demonstrate that the language of Feynman diagrams is extremely useful in establishing various properties of the model. The kernel of the unitary transformation to the SoV representation is described by the same "pyramid diagram" as appeared before in the SoV representation for the SL(2,C) spin magnet. We argue that this kernel is given by the product of the Baxter Q-operators projected onto a special reference state.

2003-01-01

377

British Library Electronic Table of Contents (United Kingdom)

For reliable operation and the optimization of production, industrial fermentation processes require appropriate tools for monitoring the process in real time. This work presents the structure and operation of a soft sensor for the on-line monitoring of biomass and product concentration during salinomycin and bacitracin fermentation in an industrial, 80-m^3 batch reactor; moreover it provides a tool for evaluation of batch production verified in industrial application. The process estimation algorithm consists of decoupled growth and product models, which ensures an unbiased convergence of the estimator and the robustness of the model. The production of secondary metabolites is described with a non-structured model upgraded with a variable forgetting factor that demonstrated a successful e...

2011-01-01

378

Method and system for controlling the idle speed of an internal combustion engine at variable ignition timing

Less BOP running with variable bore rams

The idle speed of an internal combustion engine is controlled in response to a variable ignition timing control signal from a microcomputer. The microcomputer derives this control signal as a function of the magnitude of engine speed variation which occurs during engine idle periods to cause the ignition timing to vary quickly in response to a transitory engine load variation. An auxiliary air delivery system may be advantageously incorporated in the idle speed control system to cooperate with the ignition timing control in response to the engine speed variation.

1984-05-08

379

Inclusive photoproduction of D{sup *{+-}} mesons at next-to-leading order in the general-mass variable-flavor-number scheme

The marine ram-type blowout preventer deployed from an offshore drilling rig has one serious disadvantage, its inaccessibility. A development to promote reliability of the subsea ram-type preventer and reduce the excess running and pulling to charge out rams, is the variable bare ram (VBR). Unlike the standard ram, the VBR has the ability to pack off a range of pipe sizes. Interest in VBR's has been revived and research and development in this equipment goes on at each of three manufacturer's facilities in Houston.

1984-04-01

380

Evolution of the white dwarf mass and spin in cataclysmic variables

We discuss the inclusive production of D{sup *{+-}} mesons in {gamma}p collisions at DESY HERA, based on a calculation at next-to-leading order in the general-mass variable-flavor-number scheme. In this approach, MS subtraction is applied in such a way that large logarithmic corrections are resummed in universal parton distribution and fragmentation functions and finite mass terms are taken into account. We present detailed numerical results for a comparison with data obtained at HERA and discuss various sources of theoretical uncertainties. (orig.)

2009-02-15

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381

Energy productivity in the industrial sector: an econometric analysis

We consider the spin-up of the white dwarf in non-magnetic cataclysmic variables (CVs) during secular evolution. If this is unresisted, CVs are quenched as boundary-layer emitters once the binary period has decreased by #approx# 1 hr. Angular momentum loss in nova explosions may, however, prevent the star reaching breakup. If the explosions remove (1 + #epsilon#) x the mass accreted between outbursts, values 0.5 < #approx# #epsilon# < #approx# 1 allow CVs to be modest boundary-layer emitters for most of their lifetimes. Spectral effects will limit their detection as soft X-ray sources. (author).

382

Effects of variable hardness, ph, alkalinity, suspended clay, and humics on the chemical speciation and aquatic toxicity of copper

Energy productivity and energy intensity within the industrial sector of the economy are examined. Results suggest that relative prices and other economic factors can explain much of the variation in both energy productivity and energy intensity for manufacturing and mining and for the industrial sector as a whole. Cyclical factors, seasonal factors and trend variables are also useful in explaining variation in these data, both for annual and monthly time series. Of the variables examined, it appears that the relative price of energy is a highly significant factor in accounting for the difference between actual industrial energy intensity and that which might have been expected had pre-1973 trends continued.

1983-01-01

383

Coherent state quantum key distribution with multi letter phase-shift keying

The effects of variable hardness, pH, alkalinity, humics, and suspended clay on the chemical speciation of copper and its toxicity to fathead minnow larvae in Lake Superior water were investigated. Two proposed methods (toxicity factors and chemical speciation) for predicting LC50 values in specific natural waters from laboratory toxicity data and the average site specific values of general water quality parameters were evaluated. The accuracy of the cupric ion-selective electrode in determining CU/sup +2/ activities in ambient and chemically altered Lake Superior water was also determined.

1986-03-01

384

Assessment of primary production and optical variability in shelf and slope waters near Cape Hatteras, North Carolina. Final project report

We present a protocol for quantum key distribution using discrete modulation of coherent states of light. Information is encoded in the variable phase of coherent states which can be chosen from a regular discrete set ranging from binary to continuous modulation similar to phase-shift keying in classical communication. Information is decoded by simultaneous homodyne measurement of both quadratures and requires no active choice of basis. The protocol utilizes either direct or reverse reconciliation both with and without postselection. We analyze the security of the protocol and show how to enhance it by the optimal choice of all variable parameters of the quantum signal.

2010-05-01

385

A finite-dimensional fermionic TQFT

In this project we determined primary production and optical variability in the shelf and slope waters off of Cape Hatteras, N.C. These processes were addressed in conjunction with other Ocean Margins Program investigators, during the Spring Transition period and during Summer. We found that there were significant differences in measured parameters between Spring and Summer, enabling us to develop seasonally specific carbon production and ecosystem models as well as seasonal and regional algorithm improvements for use in remote sensing applications.

2001-02-12

386

A comment on: ''The solution to the forward-bias puzzle''

A fermionic - based on Grassmann--Berezin calculus of anticommuting variables - topological quantum field theory (TQFT) is considered, mainly in three dimensions. It is defined for piecewise-linear manifolds and, for a given triangulation, deals only with a finite number of variables. Despite its simple nature, it can distiguish between lens spaces L(7,1) and L(7,2). And despite its origin from a kind of Reidemeister torsion, it does this without using nontrivial representations of the fundamental group. Also, symbolic calculations are presented giving strong evidence of existence of similar theory in four dimensions.

2011-01-01

387

British Library Electronic Table of Contents (United Kingdom)

Pippenger (2011) recently proposed a solution to the longstanding forward-bias puzzle. He argues that the puzzling estimates obtained using the standard equation for the efficient markets hypothesis are due to omitted variable bias. He identifies the missing variables as the future change in the forward exchange rate and the future interest differential. When these are added to the standard equation, he finds a one-to-one relationship between the future change in the spot rate and the forward premium. However, we argue that his equation can only test covered interest parity and offers no insight into the forward-bias puzzle.

2011-01-01

388

Stochastic analysis of contaminant transport: One-dimensional non-reactive and reactive cases

In vitro and in vivo evaluation of novel ligands for radioimmunotherapy

A reliability approach for probabilistic modeling of one-dimensional non-reactive and reactive transport in porous media provides two important quantitative results: (1) an estimate of the probability that dimensionless concentration equals or exceeds some specified level and, (2) the sensitivity of the probabilistic outcome to likely changes in each uncertain variable. The reliability approach is particularly attractive because it can incorporate various marginal probability density functions (PDF) for any of the uncertain variables. In this work uncertain variables include: groundwater flow velocity, diffusion coefficient, dispersivity, distribution coefficient, porosity and bulk density. The primary objective is to examine how the probabilistic outcome is influenced by choice of marginal PDF, correlation and magnitude of uncertainty for the variables. Because little information exists concerning the ...

1990-12-03

389

Variability and spectral modeling of the hard X-ray emission of GX 339-4 in a bright low/hard state

Novel ligands cis-2,6-bis[N,N-bis(carboxymethyl)aminomethyl]-1-piperidineacetic acid (PIP-DTPA), cis-[(1R,11S)-6,9,15-Tris-carboxymethyl-3,6,9,15-tetraazabicyclo[9.3.1] pentadec-3-yl]-acetic acid (PIP-DOTA), cis-{l_brace}2,7-bis-[bis-carboxymethyl-amino)-methyl]-azepan-1-yl{r_brace}-acetic acid (AZEP-DTPA), [2-(4,7-bis-carboxymethyl-[1,4,7]triazacyclononan-1-yl-ethyl] -2-carbonylmethyl-amino]-tetraacetic acid (NETA) and [{l_brace}4-carboxymethyl-7-[2-(carboxymethylamino)-ethyl]-perhydro-1,4,7-triazonin-1-yl{r_brace}-acetic acid (NPTA) are investigated as potential chelators of {sup 177}Lu, {sup 9}Y, {sup 212}Pb and {sup 213}Bi for radioimmunotherapy (RIT). The new ligands are radiolabeled with {sup 177}Lu, {sup 86/88/9}Y, {sup 203}Pb and {sup 205/6}Bi, and in vitro stability and in vivo stability of the radiolabeled complexes are assessed in human serum and athymic mice, respectively. In vitro studies indicate that all radiolabeled complexes with the exception of {sup 9}Y-AZEP-DTPA are ...

2006-05-15

390

The Oak Ridge Y-12 Plant biological monitoring and abatement program for East Fork Poplar Creek

We study the high-energy emission of the Galactic black hole candidate GX 339-4 using INTEGRAL/SPI and simultaneous RXTE/PCA data. By the end of January 2007, when it reached its peak luminosity in hard X-rays, the source was in a bright hard state. The SPI data from this period show a good signal to noise ratio, allowing a detailed study of the spectral energy distribution up to several hundred keV. As a main result, we report on the detection of a variable hard spectral feature (>150 keV) which represents a significant excess with respect to the cutoff power law shape of the spectrum. The SPI data suggest that the intensity of this feature is positively correlated with the 25 - 50 keV luminosity of the source and the associated variability time scale is shorter than 7 hours. The simultaneous PCA data, however, show no significant change in the spectral shape, indicating that the source is not undergoing a canonical state transition. We ...

2010-01-01

391

THE ACTIVITY AND VARIABILITY OF THE SUN AND SUN-LIKE STARS. II. CONTEMPORANEOUS PHOTOMETRY AND SPECTROSCOPY OF BRIGHT SOLAR ANALOGS

In May 1985, a National Pollutant Discharge Elimination System permit was issued for the Oak Ridge Y-12 Plant, a nuclear weapons components production facility located in Oak Ridge, Tennessee, and operated by Martin Marietta Energy Systems, Inc., for the US Department of Energy. As a condition of the permit, a Biological Monitoring and Abatement Program (BMAP) was developed to demonstrate that the effluent limitations established for the Oak Ridge Y-12 Plant protect the classified uses of the receiving stream (East Fork Poplar Creek), in particular, the growth and propagation of fish and aquatic life, as designated by the Tennessee Department of Health and Environment. A second purpose for the BMAP is to document the ecological effects resulting from implementation of a water pollution control program that will include construction of nine new wastewater treatment facilities over the next 4 years. Because of the complex nature of the effluent discharged to East Fork Poplar Creek and ...

1989-10-01

392

Stable isotopes of authigenic minerals in variably-saturated fractured tuff

We present 14 years of contemporaneous photometric and spectroscopic observations of 28 solar analog stars, taken with the Tennessee State University Automatic Photometric Telescopes at Fairborn Observatory and the Solar-Stellar Spectrograph at Lowell Observatory. These are the best observed and most nearly Sun-like of the targets in our magnitude-limited (V #<=# 7.5) sample. The correlations between luminosity and activity reveal the expected inverse activity-brightness correlations for active stars. Strong direct correlations between activity and brightness are not prevalent for the less active solar age stars, but are precision limited. The Sun does not appear to have unusually low photometric variability when compared with the most Sun-like inactive solar analogs. We present evidence that the activity index R'_H_K is not a good discriminant of Maunder Minimum candidate stars. On the basis of a star that appears to have transitioned from a ...

2009-07-01

393

Some Statistical Procedures for Evaluation of the Relative Contribution for Yield Components in irradiated populations of Peanut (Arachis hypogaea L

Identifying stable isotope variation and mineralogical changes in fractured rock may help establish the history of climatic and geomorphological processes that might affect the isolation properties of a waste repository site. This study examines the use of the stable isotope ratios of oxygen ({sup 18}O/{sup 16}O) and carbon ({sup 13}C/{sup 12}C) in authigenic minerals as hydrogeochemical tools tracing low-temperature rock-water interaction in variably-saturated fractured stuff. Isotopic compositions of fracture-filling and rock matrix minerals in the Apache Leap tuff, near Superior, Arizona were concordant with geothermal temperatures and in equilibrium with water isotopically similar to present-day meteoric water and groundwater. Oxygen and carbon isotope ratios of fracture-filling, in unsaturated fractured tuff, displayed an isotopic gradient believed to result from near-surface isotopic enrichment due to evaporation rather than the effects of rock-water ...

1988-11-01

394

Sequence of Potentials Lying Between the U(5) and X(5) Symmetries

The present investigation was conducted at Ismaillia Research Station-Agricultural Research Center, Ismaillia Governorate, during the two successive seasons of 2000 and 2001. Two varieties of peanut (Arachis hypogaea L) namely Giza 4 and Giza 5 were treated with gamma ray doses; 10,15, 20, 25 Kr in order to induce genetic variability and to study the importance of the relative contribution of peanut yield components by employing some statistical procedures, i.e. simple correlation, multiple linear regression and stepwise regression analysis. The results showed that, there was significant positive correlation between seed yield/plant and no. of pods/plant, 100 seed weight, shelling percentage and pod yield/plant, and there was significant positive correlation between pod yield/plant and no of seed/plant,100 pod weight and 100 seed weight. The multiple linear regression analysis clearly showed that the relative contribution (R"2%) of the yield components, no. of ...

2003-04-01

395

Remodeling of the free electron laser with the L-band linac at Osaka University

Starting from the original collective Hamiltonian of Bohr and separating the beta and gamma variables as in the X(5) model of Iachello, an exactly soluble model corresponding to a harmonic oscillator potential in the beta-variable (to be called X(5)-$\\beta^2$) is constructed. Furthermore, it is proved that the potentials of the form $\\beta^{2n}$ (with n being integer) provide a ``bridge'' between this new X(5)-$\\beta^2$ model (occuring for n=1) and the X(5) model (corresponding to an infinite well potential in the beta-variable, materialized for n going to infinity. Parameter-free (up to overall scale factors) predictions for spectra and B(E2) transition rates are given for the potentials $\\beta^2$, $\\beta^4$, $\\beta^6$, $\\beta^8$, corresponding to E(4)/E(2) ratios of 2.646, 2.769, 2.824, and 2.852 respectively, compared to the E(4)/E(2) ratios of 2.000 for U(5) and 2.904 for X(5). Hints about nuclei showing this ...

2004-01-01

396

Relationships between bone structure in the iliac crest and bone structure and strength in the lumbar spine.

The far infrared free electron laser (FEL) has been being developed since 1990 using the L-band electron linac at the Institute of Scientific and Industrial Research, Osaka University. The first lasing was obtained in 1994 at wavelengths from 32 to 40 #mu#m. The FEL is now being modified suitable for user experiments. The wiggler with a fixed magnet gap used in the original FEL has been remodeled to make the magnet gap variable. In order to optimize the variable range of the gap, the gain and the diffraction loss were calculated. The peak gain is calculated to be 270% and the diffraction loss to be 22% at 150 #mu#m. The wavelength is expected to be variable from 25 up to at least 150 #mu#m. The two bending magnets in the optical resonator have been remodeled and the vacuum chambers with larger vertical sizes for them have been newly made so that the diffraction loss in these parts becomes smaller than that in the vacuum ...

1997-02-28

397

Optimal control of the free boundary in a two-phase Stefan problem

The purpose of this study was to examine the relationship between histomorphometric variables of cancellous bone structure and ultimate compressive strength (UCS) in the second lumbar vertebra (L2) and to determine whether structural variables in the iliac crest are predictive of the same variables and of UCS in L2. At autopsy, 7.5 mm diameter cores were removed from the iliac crest and from L2 of 29 subjects who had died suddenly without bone disease. Cancellous bone volume (BV/TV, %) was significantly lower in L2 than in iliac crest due to lower trabecular number (Tb.N, per mm) and thickness (Tb.Th, microns). There were significant correlations between iliac crest and L2 for BV/TV, Tb.N and trabecular separation (Tb.Sp, microns), but not for Tb.Th. BV/TV was negatively correlated, and Tb.Sp was positively correlated with age at both sites. Tb.Th was not significantly correlated with age in the iliac crest, but a ...

1993-03-01

398

Groundwater travel time uncertainty analysis. Sensitivity of results to model geometry, and correlations and cross correlations among input parameters

We present an optimal control approach for the solidification process of a melt in a container. The process is described by a two phase Stefan problem with the free boundary (interface between the two phases) modelled as a graph. We control the evolution of the free boundary using the temperature on the container wall. The control goal consists in tracking a prescribed evolution of the free boundary. We achieve this goal by minimizing a appropriate cost functional. The resulting minimization problem is solved numerically by a steepest descent method with step size control, where the gradient of the cost functional is expressed in terms of the adjoint variables. Several numerical examples are presented which illustrate the performance of the method. The novelty of the approach presented consists in using a sharp interface model for the control of the free boundary. This guarantees direct access to the free boundary as optimization variable in ...

2007-05-01

399

Epidemiologic studies of coronary heart disease and stroke in Japanese men living in Japan, Hawaii, and California: demographic, physical, dietary, and biochemical characteristics

This study examines the sensitivity of the travel time distribution predicted by a reference case model to (1) scale of representation of the model parameters, (2) size of the model domain, (3) correlation range of log-transmissivity, and (4) cross correlations between transmissivity and effective thickness. The basis for the reference model is the preliminary stochastic travel time model previously documented by the Basalt Waste Isolation Project. Results of this study show the following. The variability of the predicted travel times can be adequately represented when the ratio between the size of the zones used to represent the model parameters and the log-transmissivity correlation range is less than about one-fifth. The size of the model domain and the types of boundary conditions can have a strong impact on the distribution of travel times. Longer log-transmissivity correlation ranges cause larger variability in the predicted travel times. ...

1985-03-01

400

Development, field testing and implementation of automated hydraulically controlled, variable volume loading systems for reciprocating compressors

These summary descriptive data of ethnically similar cohorts of indigenous and migrant Japanese males have shown similarities or slight differences in characteristics wholly or largely genetically determined, such as blood groups, stature, and skeletal size. Differences have been noted in characteristics largely environmental or behavioral, such as diet and cigarette smoking habit, as well as in characteristics determined by a varying mixture of genetic and environmental influences, such as weight, blood pressure, glucose tolerance, and serum lipid and uric acid levels. Detailed analyses of the distributions of laboratory variables, of dietary data obtained by different methods, and of correlations among laboratory, dietary, physical, and demographic variables are currently in progress. Also part of the study plan are determinations of disease prevalence from evaluation of examination, laboratory, and electrocardiographic findings, of disease ...

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

401

Advanced fuzzy logic controllers design and evaluation for buildings' occupants thermal-visual comfort and indoor air quality satisfaction

Automated, variable volume unloaders provide the ability to smoothly load/unload reciprocating compressors to maintain ideal operations in ever-changing environments. Potential advantages provided by this load control system include: maximizing unit capacity, optimizing power economy, maintaining low exhaust emissions, and maintaining process suction and discharge pressures. Obstacles foreseen include: reliability, stability, serviceability and automation integration. Results desired include: increased productivity for the compressor and its operators, increased up time, and more stable process control. This presentation covers: system design features with descriptions of how different types of the devices were developed, initial test data, and how they can be effectively operated; three actual-case studies detailing the reasons why automated, hydraulically controlled, variable volume, head-end unloaders were chosen over other types of ...

2003-07-01

402

Abundance of West Nile virus mosquito vectors in relation to climate and landscape variables.

The aim of this paper is to present and evaluate control strategies for adjustment and preservation of air quality, thermal and visual comfort for buildings' occupants while, simultaneously, energy consumption reduction is achieved. Fuzzy PID, fuzzy PD and adaptive fuzzy PD control methods are applied. The inputs to any controller are: the PMV index affecting thermal comfort, the CO{sub 2} concentration affecting indoor air quality and the illuminance level affecting visual comfort. The adaptive fuzzy PD controller adapts the inputs and outputs scaling factors and is based on a second order reference model. More specifically, the scaling factors are modified according to a sigmoid type function, in such a way that the measured variable to be as closer as possible to the reference model. The adaptive fuzzy PD controller is compared to a non-adaptive fuzzy PD and to an ON-OFF one. The comparison criteria are the energy required and the controlled ...

2001-07-01

403

A variability study of the first catalog of gamma-ray sources on the 2.3 years AGILE data archive

It is currently unclear if the potential for West Nile virus transmission by mosquito vectors in the eastern United States is related to landscape or climate factors or both. We compared abundance of vector species between urban and suburban neighborhoods of Henrico County, VA, in relation to the following factors: temperature, precipitation, canopy cover, building footprint, and proximity to drainage infrastructure. Mosquitoes were collected throughout the 2005, 2006, and 2007 seasons and tested for West Nile virus (WNV) in pools of 10-50. Test results of mosquito pools were compared to average site abundance from 37 sites in Henrico County, VA; abundance was then examined in relation to ecological variables. Urban infrastructure was positively correlated with the abundance of Culex pipiens L./Cx. restuans, and our findings implicate combined sewer overflow systems as large contributors to Culex vector populations. No measure of urbanization examined in our study ...

2011-06-01

404

A dynamic approach to the Environmental Kuznets Curve hypothesis

AGILE pointed observations performed from July 9, 2007 to October 30, 2009 are a recent, high quality gamma-ray data archive for monitoring studies of medium to high brightness gamma-ray sources in the 30 MeV -50 GeV energy range. We present a variability study of the 1AGL sources over the complete AGILE pointed Observation Blocks (OBs) dataset. The first AGILE Gamma-Ray Imaging Detector (GRID) catalog (Pittori et al. 2009) included a significance-limited (4 sigma) sample of 47 sources (1AGL), detected with a conservative analysis over a first-year non-uniform sky coverage dataset. In this analysis we used data of an improved full Field of View (FOV) event filter, on a much larger (about 27.5 months) observation dataset, analyzing each OB separatedly. This data processing resulted in an improved source list as compared to the 1AGL one. We present here some results on the variability of some of these sources.

2010-01-01

405

A dynamic approach to the Environmental Kuznets Curve hypothesis

The Environmental Kuznets Curve (EKC) hypothesis states that pollution levels increase as a country develops, but begin to decrease as rising incomes pass beyond a turning point. In EKC analyses, the relationship between environmental degradation and income is usually expressed as a quadratic function with the turning point occurring at a maximum pollution level. Other explanatory variables have been included in these models, but income regularly has had the most significant effect on indicators of environmental quality. One variable consistently omitted in these relationships is the price of energy. This paper analyzes previous models to illustrate the importance of prices in these models and then includes prices in an econometric EKC framework testing energy/income and CO{sub 2}/income relationships. These long-run price/income models find that income is no longer the most relevant indicator of environmental quality or energy demand. Indeed, ...

1999-02-01

406

Wind systems life cycle cost analysis: a description and users manual. [LIFECC

The Environmental Kuznets Curve (EKC) hypothesis states that pollution levels increase as a country develops, but begin to decrease as rising incomes pass beyond a turning point. In EKC analyses, the relationship between environmental degradation and income is usually expressed as a quadratic function with the turning point occurring at a maximum pollution level. Other explanatory variables have been included in these models, but income regularly has had the most significant effect on indicators of environmental quality. One variable consistently omitted in these relationships is the price of energy. This paper analyzes previous models to illustrate the importance of prices in these models and then includes prices in an econometric EKC framework testing energy/income and CO_2/income relationships. These long-run price/income models find that income is no longer the most relevant indicator of environmental quality or energy demand. Indeed, we ...

1999-02-01

407

What explains default risk premium during the financial crisis? Evidence from Japan

This report describes the LIFECC computer program developed for the purpose of calculating the cost of energy produced by wind systems according to the principles of life cycle costing (LCC). Following a brief explanation of the LCC concept and its advantages, input variables to the program and their importance to various program users, including manufacturers and designers, utilities, various institutions and consumers, are explained. A detailed user's guide to the program is then provided, together with a sensitivity analysis which discusses the impact of key variables on wind system cost of energy and the importance of cash flow to the wind system purchaser. Sample cases of program output and an LIFECC program listing are provided.

1982-07-01

408

British Library Electronic Table of Contents (United Kingdom)

As is well documented, subprime mortgage markets carried significant default risk. This paper investigates the relationship between default risk premium, stock market conditions and macroeconomic variables during the financial crisis. Using iTraxx Japan Credit Default Swap (CDS) index spreads covering the period from March 2006 to November 2009, we employ a time-varying dynamic factor model with Markov regime switching to generate regime probabilities for default risk. We analyze the sensitivity of default risk premium changes to stock market conditions and macroeconomic variables by using two-state Markov switching models: a crisis regime sparked by rising loan defaults in the sub-prime mortgage market, and a non-crisis regime. We found strong evidence that the relationship between defaul...

2011-01-01

409

Variable structure system based logic fuzzy control of bridge vibration using fail-safe magnetorheological fluid dampers

Understanding Formulation Systems—A Six Sigma Approach

This paper presents a semi-active vibration control of a scaled two-span bridge structure. Magneto-rheological fluid dampers are utilized as the semi-active energy absorbing deices and a bridge vibration control system is developed. Closed-loop control system based on fuzzy logic is used to suppress the bridge deck motion under random excitations. The sufficient condition for the closed-loop stability of the fuzzy control system is derived from the variable structure system theory. It is demonstrated that this stable fuzzy control system can significantly reduce the relative deck displacement using about 55 percent less power compared to passive-on state, while the absolute deck acceleration is relatively unaffected.

2002-06-01

410

British Library Electronic Table of Contents (United Kingdom)

The broad use of Six Sigma in the improvement of all types of processes has provided new insight for how to design, analyze, and interpret formulation studies and mixture experiments. Experience has shown that, consistent with the Pareto principle, there are typically three to six key variables that have major effects on the performance of the process. Identifying these key variables increases your ability to control and optimize the process. Applying this concept to formulation studies suggests that we should be searching for those critical few components that are driving the performance of the product formulation. This thinking changes how we approach both the design and analysis phases of product formulation studies, including the reassessment of formulations in use today. A review of t...

2011-01-01

411

Two-boson algebra and quantum computing with Josephson-like systems

To Get Overall Shapes and New Data of the 120-Cell and the 600-Cell

Our investigation concerns the class of Josephson-like systems, sharing the same nonlinear Hamiltonian. Among the latter a Josephson junction with an external biasing circuit is considered. We diagonalize the fully nonlinear Hamiltonian (in the superconductive regime of the junction) in the Fock space of the TBHA (two-boson Heisenberg algebra) and prove that such algebra leads quite naturally to the theoretical realization of codewords and logical operators: the codewords are defined as the even and odd coherent states of the TBHA, while the logical operators are expressed in terms of operators in the same algebra. Our theoretical construction corresponds to a continuous variable quantum computation scheme; the continuous variables are identified in terms of the physical operators of the junction. The link between this scheme and the technique of fermionization of bosonic systems is also discussed.

2005-12-01

412

Three dimensional simulation of compressible and incompressible flows through the finite element method; Simulacao tridimensional de escoamentos compressiveis e incompressiveis atraves do metodo dos elementos finitos

This research will be helpful for people to display the 2-dimensiona projective models of 4-variable actual problems in many fields, in order to investigate deeply those actual problems. By using the theory of N-dimensional finite rotation group of the regular polytopes, the author established the 2-dimensional projective model of 4-dimensional rectangular coordinate system, and deduced a transformation matrix, and adopt it to display successfully the 2-dimensional overall shapes of two most complicated regular polytopes 120-Cell and 600-Cell. In the meantime, the author calculated all the vertex coordinates and determine the joint relationships between adjacent vertices of the regular polytopes 120-Cell and 600-Cell. Also, this provided a pattern for displaying the 2-dimensional projective model of 4-variable actual problem.

2009-01-01

413

Technologies for Saving Energy in Railway Operation: General Discussion on Energy Issues Concerning Railway Technology

Although incompressible fluid flows can be regarded as a particular case of a general problem, numerical methods and the mathematical formulation aimed to solve compressible and incompressible flows have their own peculiarities, in such a way, that it is generally not possible to attain both regimes with a single approach. In this work, we start from a typically compressible formulation, slightly modified to make use of pressure variables and, through augmenting the stabilising parameters, we end up with a simplified model which is able to deal with a wide range of flow regimes, from supersonic to low speed gas flows. The resulting methodology is flexible enough to allow for the simulation of liquid flows as well. Examples using conservative and pressure variables are shown and the results are compared to those published in the literature, in order to validate the method. (author)

2004-11-15

414

British Library Electronic Table of Contents (United Kingdom)

Early technical history of electric supply to electric railways is briefly reviewed as an introduction to the following seven papers included in this special issue on technologies for saving energy in railway operation. Continuous power supply played a significant role in the early history of railway technologies. The variable voltage variable frequency (VVVF) power electronic technology had also a substantial impact on railway traction systems after 1980s. VVVF technology made it possible to have more efficient drives, downsize rolling stocks, and develop regenerative brakes. Because detailed discussions on each technical development are presented in the following papers, the general remarks of those technologies made in this introduction provide logical links to the ideas presented in th...

2010-01-01

415

Spatial and seasonal variability in cetacean distribution in the fjords of northern Patagonia, Chile

British Library Electronic Table of Contents (United Kingdom)

Viddi, F. A., Hucke-Gaete, R., Torres-Florez, J. P., and Ribeiro, S. 2010. Spatial and seasonal variability in cetacean distribution in the fjords of northern Patagonia, Chile. - ICES Journal of Marine Science, 67: 959-970. Compared with other Chilean coastal areas, little is known about the diversity and distribution of cetaceans in northern Patagonian fjords. Between December 2000 and November 2001, surveys on platforms of opportunity were undertaken in southern Chile to evaluate species richness and the spatial and seasonal distribution of cetaceans. Nine species were recorded, blue, humpback, and minke whales, Peales dolphin, Chilean dolphin, killer whale, false killer whale, bottlenose dolphin, and Cuviers beaked whale. The pattern of cetacean distribution displayed significant season...

2010-01-01

416

Solution of free vibration equations of semi-rigid connected Reddy?Bickford beams resting on elastic soil using the differential transform method

British Library Electronic Table of Contents (United Kingdom)

The literature regarding the free vibration analysis of Bernoulli?Euler and Timoshenko beams under various supporting conditions is plenty, but the free vibration analysis of Reddy?Bickford beams with variable cross-section on elastic soil with/without axial force effect using the Differential Transform Method (DTM) has not been investigated by any of the studies in open literature so far. In this study, the free vibration analysis of axially loaded and semi-rigid connected Reddy?Bickford beam with variable cross-section on elastic soil is carried out by using DTM. The model has six degrees of freedom at the two ends, one transverse displacement and two rotations, and the end forces are a shear force and two end moments in this study. The governing differential equations of motion of the r...

2011-01-01

417

Satellite monitoring of climatic factors regulating phytoplankton variability in the Arabian (Persian) Gulf

British Library Electronic Table of Contents (United Kingdom)

Possible factors regulating phytoplankton variability in the Arabian (Persian) Gulf were analyzed on the basis of satellite observations and meteorological data (1997-2009), including remotely-sensed chlorophyll a concentration (CHL), sea surface temperature, wind, solar radiation, precipitation, and aerosols. Shallow waters of northwestern Gulf influenced by Shatt Al-Arab River discharge were more productive than open Gulf waters, although seasonal CHL patterns in this and other shallow regions looked unrealistic likely because the CHL signal was obscured by bottom reflection. Therefore our further analyses focused on the open Gulf waters, which show a subtropical seasonal CHL cycle with maximum in winter and minimum in spring-summer. This cycle, however, was decoupled from the seasonal e...

2010-01-01

418

Risk of sperm competition does not influence copulatory behavior in the promiscuous meadow vole (Microtus pennsylvanicus)

British Library Electronic Table of Contents (United Kingdom)

It is not clear whether males in all mammalian species adjust their copulatory behavior when faced with risk of sperm competition (RSC). Previous work on meadow voles, Microtus pennsylvanicus, indicated that males increase their sperm expenditure but not the number of ejaculations in the presence of odors of a conspecific male. The present study follows up on this work and asks whether male meadow voles modify any aspect of their copulatory behavior when they face a RSC. We examined 46 variables of copulatory behavior and found that the presence of odors from a conspecific male did not affect any of these variables. Thus, male meadow voles, unlike some other species of mammals, do not adjust their copulatory behavior when exposed to cues associated with an elevated RSC.

2007-01-01

419

Relationship between historical sea-surface temperature variability and climate change-induced coral mortality in the western Indian Ocean

British Library Electronic Table of Contents (United Kingdom)

Many of the world's coral reefs suffered high coral mortality during the 1998 ENSO, with the highest mortality in the western Indian Ocean (WIO). A meta-analysis of field data on change in coral cover across the 1998 ENSO event was conducted for 36 major reef areas in the WIO, and relationship of the change with the historical sea-surface temperature (SST) variability investigated. WIO reefs were categorized into three major SST groups of differing coral cover change. Cover change was negatively associated with standard deviation (SD) SST until about SD 2.3, with increasing flatness of the SST frequency distributions. It increased with further increase in SD as the SST distributions became strongly bimodal in the Arabian/Persian Gulf area. The study indicates that environmental resistance/...

2010-01-01

420

Reduction of fluoroscopic exposure for the air-contrast barium enema

Rapid optical variability of TeV blazars

In a fluoroscopic imaging system, image quality and patient dose are both affected by the optical system linking the image intensifier with the video camera. The effect on patient exposure of increasing the optical iris aperture size over that required for other procedures performed on the same imaging system was investigated for the air-contrast barium enema examination. Using a large-area transmission ionisation chamber to monitor the Roentgen-area-product of entrance exposure, a decrease in fluoroscopic radiation of greater than 50% was clinically documented for a fluoroscopic system utilising kVp and mA variable automatic brightness control. For this iris change, the video image was of acceptable quality for positioning and monitoring the patient, and no deleterious effect was detected in the conduct of the air-contrast exam. The availability of a variable-sized operator-selectable iris diaphragm would permit this dose-reduction approach to ...

1983-11-01

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421

British Library Electronic Table of Contents (United Kingdom)

Abstract In this first systematic attempt to characterize the intranight optical variability (INOV) of TeV-detected blazars, we have monitored a well-defined set of nine TeV blazars on total 26 nights during 2004-10. In this R- or V-band-monitoring programme only one blazar was monitored per night and the minimum duration was close to 4-h, the average being 5.3 h per night. Using the CCD for strictly simultaneous photometry of the blazar and nearby reference stars (N-star photometry), an INOV detection threshold of -1-2-per cent was achieved in the densely sampled differential light curves derived from our data. We have further expanded the sample by including another 13 TeV blazars, taking advantage of the availability in the literature of INOV data, including those published earlier in o...

2011-01-01

422

Prioritizing areas in the native range of hygrophila for surveys to collect biological control agents

British Library Electronic Table of Contents (United Kingdom)

Native to Southeast Asia, Hygrophila polysperma is an invasive aquatic weed of lotic habitats in the southern United States and Mexico. An increase in the number of water bodies invaded by hygrophila since 1990 suggests that current methods employed to control this weed are inadequate. Classical biological control may be a viable option for long term regulation of hygrophila in the invaded range. In this study, we used the Maximum Entropy Species Distribution Model (MaxEnt) to prioritize climatically suitable native habitats in India and Bangladesh for conducting exploratory surveys to collect biological control agents. In total, 164 point occurrences from the United States and Mexico and 20 predictor variables, including 19 bioclimatic variables and altitude, were used to predict the nati...

2011-01-01

423

Pd based membrane reactor for ultra pure hydrogen production through the dry reforming of methane. Experimental and modeling studies

British Library Electronic Table of Contents (United Kingdom)

A dense Pd-Ag membrane reactor (MR) with 100% hydrogen selectivity packed with either Rh/La2O3 or Rh/La2O3-SiO2 as catalysts was used to carry out the dry reforming of methane. The membrane reactor simulation was performed using a well-known reactor model. For this purpose, we employed the equations derived from complete kinetic studies of the dry reforming of methane reaction in connection with both catalysts. In addition, we developed the kinetic equation for the reverse water gas shift reaction (RWGS). The combination of detailed kinetic studies with the measured permeation flux for the Pd-Ag membrane allowed a complete comparison between experimental and simulated operation variables. The variables studied for both catalysts were methane conversion and hydrogen permeation as a function...

2011-01-01

424

Partition Functions of Normal Factor Graphs

On the disrupted magnetic braking model for the period gap of cataclysmic variables

One of the most common types of functions in mathematics, physics, and engineering is a sum of products, sometimes called a partition function. After "normalization," a sum of products has a natural graphical representation, called a normal factor graph (NFG), in which vertices represent factors, edges represent internal variables, and half-edges represent the external variables of the partition function. In physics, so-called trace diagrams share similar features. We believe that the conceptual framework of representing sums of products as partition functions of NFGs is an important and intuitive paradigm that, surprisingly, does not seem to have been introduced explicitly in the previous factor graph literature. Of particular interest are NFG modifications that leave the partition function invariant. A simple subclass of such NFG modifications offers a unifying view of the Fourier transform, tree-based reparameterization, loop calculus, and ...

2011-01-01

425

Neural integrated control for a free-floating space robot with suddenly changing parameters

The disrupted magnetic braking theory for the period gap of cataclysmic variable systems is used to study the binary evolution of low-mass main-sequence-like stars with white dwarf companions. The model is able to reproduce the observed location and width of the gap provided that the average mass transfer rates above the upper edge of the gap are greater than about 1.9 x 10 to the -9th solar masses/yr. For the case of angular momentum loss by magnetic braking, the slope of the mass transfer rate with respect to orbital period is shown to range from 3.4 to 3.7. For the evolutionary sequences considered, the He-3 abundance at the surface of the secondary exceeds 0.0015 after the complete mixing phase, resulting in modifications in the nuclear burning development of nova explosions. 31 refs.

426

British Library Electronic Table of Contents (United Kingdom)

Because the state of a free-floating space robot model is uncertain and sudden changes in the model parameters might undermine the stability of the system, this paper proposes a control strategy based on a variable structure neural integrated controller. This scheme does not need a precise space robot model, making use of the radial basis function neural network ability approach to learn about an uncertain model. The network weights are adjusted online in real-time. During the early period of the control phase and parameter changes, the variable structure controller compensates for the uncertain model which the neural network could not learn well. It also creates global asymptotic stability for the whole closed-loop system. Simulation results show that the controller can handle bad changea...

2011-01-01

427

Multiobjective design of Work-In-Process buffer for scheduling repetitive building projects

British Library Electronic Table of Contents (United Kingdom)

Variability in production is one of the largest factors that negatively impacts construction project performance. A common construction practice to protect production systems from variability is the use of buffers (Bf). Construction practitioners and researchers have proposed buffering approaches for different production situations, but these approaches have faced practical limitations in their application. A multiobjective analytic model (MAM) is proposed to develop a graphical solution for the design of Work-In-Process (WIP) Bf in order to overcome these practical limitations to Bf application, being demonstrated through the scheduling of repetitive building projects. Multiobjective analytic modeling is based on Simulation?Optimization (SO) modeling and Pareto Fronts concepts. Simulation...

2009-01-01

428

Moral Judgments Recruit Domain-General Valuation Mechanisms to Integrate Representations of Probability and Magnitude

British Library Electronic Table of Contents (United Kingdom)

Summary Many important moral decisions, particularly at the policy level, require the evaluation of choices involving outcomes of variable magnitude and probability. Many economic decisions involve the same problem. It is not known whether and to what extent these structurally isomorphic decisions rely on common neural mechanisms. Subjects undergoing fMRI evaluated the moral acceptability of sacrificing a single life to save a larger group of variable size and probability of dying without action. Paralleling research on economic decision making, the ventromedial prefrontal cortex and ventral striatum were specifically sensitive to the "expected moral value" of actions, i.e., the expected number of lives lost/saved. Likewise, the right anterior insula was specifically sensitive to outcome p...

2010-01-01

429

Modelling the impacts of weather and climate variability on crop productivity over a large area: A new super-ensemble-based probabilistic projection

British Library Electronic Table of Contents (United Kingdom)

Estimates of climate change impacts are plague with uncertainties from many physical, biological, and social-economic processes. Among the urgent research priorities, more comprehensive assessments of impacts that better represent the uncertainties are needed. Here, we develop a new super-ensemble-based probabilistic projection approach to account for the uncertainties from CO2 emission scenarios, climate change scenarios, and biophysical processes in impact assessment model. We demonstrate the approach in addressing the probabilistic changes of maize production in the North China Plain in future. The new process-based general crop model, MCWLA [Tao, F., Yokozawa, M. Zhang, Z., 2009. Modelling the impacts of weather and climate variability on crop productivity over a large area: a new proc...

2009-01-01

430

Learning Undirected Graphical Models with Structure Penalty

Issues in the use of short-term radon concentration measurements for estimating long-term exposures

In undirected graphical models, learning the graph structure and learning the functions that relate the predictive variables (features) to the responses given the structure are two topics that have been widely investigated in machine learning and statistics. Learning graphical models in two stages will have problems because graph structure may change after considering the features. The main contribution of this paper is the proposed method that learns the graph structure and functions on the graph at the same time. General graphical models with binary outcomes conditioned on predictive variables are proved to be equivalent to multivariate Bernoulli model. The reparameterization of the potential functions in graphical model by conditional log odds ratios in multivariate Bernoulli model offers advantage in the representation of the conditional independence structure in the model. Additionally, we impose a structure penalty on groups of ...

2011-01-01

431

Ignition delay as determined in a variable-compression ratio direct-injection diesel engine

Short-duration measurements have been widely used to screen for exposures to elevated radon concentrations in individual houses or at state or regional levels. However, a number of factors, including spatial and temporal variability in radon concentrations, must be considered before comparison to concentration guidelines can be made. Daily variations in radon concentration can lead to inherent measurement uncertainties ranging from 20 to 100+ percent. Differences in radon concentration due to seasonal effects and/or sampling location are also variable, and do not appear to be regionally consistent. Winter/summer concentration ratios, for example, have been observed to vary by as much as a factor of 10 in basements and by a factor of 5 in first floors. In this paper the implications of these uncertainties on the use of short-term sampling for inferring long-term exposures are discussed.

1990-02-19

432

Hydrothermal faunal assemblages and habitat characterisation at the Eiffel Tower edifice (Lucky Strike, Mid-Atlantic Ridge)

A variable-compression ratio, direct-injection diesel engine (VCR) has been designed and assembled at Southwest Research Institute with the intention of examining the current procedures for rating the ignition quality of diesel fuels and the meaning of ignition delay as an indicator of ignition and combustion quality. Using a slightly modified ASTM D 613 procedure, the engine has been used to rate the ignition quality of 43 different test fuels. The ratings obtained in the VCR engine are compared to the corresponding rating obtained using the standard cetane rating procedure. Some of the problems associated with the standard procedure became apparent during these experiments. The experimental results are discussed in terms of the problems and the advantages of a proposed VCR-based rating procedure.

1987-01-01

433

British Library Electronic Table of Contents (United Kingdom)

Abstract The Eiffel Tower edifice is situated in the Lucky Strike hydrothermal vent field at a mean depth of 1690-m on the Mid-Atlantic Ridge (MAR). At this 11-m-high hydrothermal structure, different faunal assemblages, varying in visibly dominant species (mussels and shrimp), in mussel size and in density of mussel coverage, were sampled biologically and chemically. Temperature and sulphide (-S) were measured on the different types of mussel-based assemblages and on a shrimp-dominated assemblage. Temperature was used as a proxy for calculating total concentrations of CH4. Based on the physico-chemical measurements, two microhabitats were identified, corresponding to (i) a more variable habitat featuring the greatest fluctuations in environmental variables and (ii) a second, more stable, ...

2011-01-01

434

Genetic algorithm approach for the determination of the electrical parameters of railway traction lines

British Library Electronic Table of Contents (United Kingdom)

The problem of electrical parameters identification in complex systems, and in particular in electric railway traction systems, is considered. Parameters are determined by an indirect approach: only the terminal variables (voltages and currents and, impedance and admittance, which can be readily calculated) are measured and the per-unit-length electrical parameters are determined using a multiconductor transmission line model of the track section under test. It will be shown that some parameters cannot be measured directly, that they are not constant with frequency and that they may depend on other external conditions. An indirect method for parameters identification is proposed through an adaptive algorithm (AA), so that the calculated terminal variables match the measured ones. The AA is...

2008-01-01

435

Experimental assessment of energy storage via variable speed compressor

British Library Electronic Table of Contents (United Kingdom)

In this study, usage of a variable speed refrigeration system in latent heat thermal energy storage (LHTES) system is investigated to increase energy storage efficiency. Four different compressor speed control cases are compared to obtain a constant heat transfer fluid (HTF) temperature at the inlet of the energy storage tank. These control cases are (i) control with evaporation temperature, (ii) control with ethylene glycol temperature at the outlet section of evaporator, (iii) control with suction pressure of the compressor and (iv) on/off control. By means of the experimental analysis the best control strategy is obtained as control with Case (ii), in terms of stability of inlet temperature of heat transfer fluid, variations of energy efficiency of LHTES and coefficient of performance (...

2011-01-01

436

Evaluation and optimization of organosolv pretreatment using combined severity factors and response surface methodology

British Library Electronic Table of Contents (United Kingdom)

In this study, ethanol organosolv pretreatment was investigated and optimized for the pretreatment of empty palm fruit bunch using (1) response surface methodology based on three-variable central composite design and (2) the combined severity parameters. The reaction parameters studied were sulfuric acid concentration (0.5-2.0%), reaction temperature (160-200^oC) and residence time (45-90min). Both models provide valuable and complementary informations: using combined severity parameters, very good predictions were obtained concerning xylan and lignin extraction whereas central composite design is the best model for glucose production. The optimal values of the variables were as the followings: sulfuric acid 2.0% w/w, 160^oC, 78min and the experimental values (96.0%) concerning glucose and...

2011-01-01

437

Effects of heat loss as percentage of fuel's energy, friction and variable specific heats of working fluid on performance of air standard Otto cycle

British Library Electronic Table of Contents (United Kingdom)

The objective of this study is to analyze the effects of heat loss characterized by a percentage of the fuel's energy, friction and variable specific heats of working fluid on the performance of an air standard Otto cycle with a restriction of maximum cycle temperature. A more realistic and precise relationship between the fuel's chemical energy and the heat leakage that is based on a pair of inequalities is derived through the resulting temperature. The variations in power output and thermal efficiency with compression ratio, and the relations between the power output and the thermal efficiency of the cycle are presented. The results show that the power output as well as the efficiency where maximum power output occurs will increase with increase of the maximum cycle temperature. The temp...

2008-01-01

438

Dynamic construction of outage lists for safety analysis of power transmission lines. Dynamische Erstellung von Ausfallisten fuer die Sicherheitsanalyse elektrischer Energieuebertragungssysteme

Covariance of quantum general relativity from Ashtekar variables

An adaptive contingency selection process is set up which produces outage lists in order to guarantee on-line network security control. The quality index system used so far did not detect and reveal all critical variables due to observation problems in the mapping of two functions. The new process uses the results of the outage simulation computing of the system status just past for the drawing up of an up-to-date outage list. A linear correcting function transform the G{sub 2}-values of the standard quality index method - which still incorporate the observation problem effect - into improved values G. Studies which use data from realstic high-voltage networks prove that the detection of critical variables is far superior to ordinary methods. (orig.).

1990-04-23

439

Challenges in presenting high dimensional data to aid in triage in the DARPA virtual soldier project.

In this paper we examine the relationship between covariance and unitarity for quantum gravity in Ashtekar variables. A usual description would discard half of the original Lorentz group, in exchange for the resulting simplifications of general relativity. We start by quantizing a trivial SL(2,C) gauge theory resulting in a nonunitary covariant theory. By the addition of a total time derivative we transform this into a unitary theory of the Ashtekar description of gravity with complete accountability of the degrees of freedom. We find that covariance on the spacetime level bears a direct relationship to covariance on the level ofthe quantum fields themselves. This procedure can in principle be applied to any totally constrained system, and bears a resemblance to the Gupta--Bleuler method. Finally, we make some observation regarding the loop representation of the SL(2,C) connection.

2008-01-01

440

Bioprocess control from a multivariate process trajectory.

One of the goals of the DARPA Virtual Soldier Project is to aid the field medic in the triage of a casualty. In Phase I, we are currently collecting 12 baseline experimental physiological variables and a cardiac gated Computed Tomography (CT) imagery for use in an prototyping a futuristic electronic medical record, the "Holomer". We are using physiological models and Kalman filtering to aid in diagnosis and predict outcomes in relation to cardiac injury. The physiological modeling introduces another few hundred variables. Reducing the complexity of the above into easy-to-read text to aid in the triage by the field medic is the challenge with multiple display solutions. A description of the possible techniques follows. PMID:15718701

2005-01-01

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441

Biodynamic modelling of the accumulation of Ag, Cd and Zn by the deposit-feeding polychaete Nereis diversicolor: Inter-population variability and a generalised predictive model

A multivariate bioprocess control approach, capable of tracking a pre-set process trajectory correlated to the biomass or product concentration in the bioprocess is described. The trajectory was either a latent variable derived from multivariate statistical process monitoring (MSPC) based on partial least squares (PLS) modeling, or the absolute value of the process variable. In the control algorithm the substrate feed pump rate was calculated from on-line analyzer data. The only parameters needed were the substrate feed concentration and the substrate yield of the growth-limiting substrate. On-line near-infrared spectroscopy data were used to demonstrate the performance of the control algorithm on an Escherichia coli fed-batch cultivation for tryptophan production. The controller showed good ability to track a defined biomass trajectory during varying process dynamics. The robustness of the control was high, despite significant external ...

2003-09-05

442

British Library Electronic Table of Contents (United Kingdom)

Biodynamic parameters of the ragworm Nereis diversicolor from southern Spain and south England were experimentally derived to assess the inter-population variability of physiological parameters of the bioaccumulation of Ag, Cd and Zn from water and sediment. Although there were some limited variations, these were not consistent with the local metal bioavailability nor with temperature changes. Incorporating the biodynamic parameters into a defined biodynamic model, confirmed that sediment is the predominant source of Cd and Zn accumulated by the worms, accounting in each case for 99% of the overall accumulated metals, whereas the contribution of dissolved Ag to the total accumulated by the worm increased from about 27 to about 53% with increasing dissolved Ag concentration. Standardised va...

2010-01-01

443

An economic planning tool for geothermal energy projects

A variable step-down conversion ratio switched capacitor DC-DC converter for energy harvesting systems working in intermittent mode

Three geothermal direct heat applications were examined to derive a set of cost estimates from which one could determine the effect of changes in system parameters (temperature, flow, load, etc.) on the cost of heat. For each application, a set of resource characteristics and system inputs were chosen to best represent a site specific baseline condition. The baseline estimated cost of heat was calculated along with other cost estimates representing optimistic and pessimistic conditions, bracketing the range any input variable might reasonably take. Regression equations based upon these cost estimates were developed for each application to quantitatively relate changes in cost to changes in the input variables. These three equations and their accompanying nomographs serve as easily understandable planning tools for direct heat geothermal energy projects.

1980-12-01

444

12-month follow-up of first-episode psychosis in Finland and Spain-differential significance of social adjustment-related variables

Energy harvesting systems stimulate the development of power management for low power consumption applications. Improving the converter efficiency of power management circuits has become a significant issue in energy harvesting system design. This paper presents a variable step-down conversion ratio switched capacitor (SC) DC-DC converter to advance the converter efficiency of charge on the stored capacitor in a wireless monitoring system of orthopedic implants. The converter is designed to work at 1 MHz switching frequency and achieves 15 to 2 V conversion. Measurement results show that the converter efficiency can reach 42% including all circuit power consumption, which is much higher than previous work. (semiconductor integrated circuits)

2009-12-01

445

British Library Electronic Table of Contents (United Kingdom)

Abstract Objective:- This study explored 12-month outcome and its associations to social adjustment-related variables in patients with first-episode non-affective psychosis in Finland and Spain. Methods:- Forty-nine Finnish and 37 Spanish patients were evaluated at admission on various characteristics of social adjustment. Outcome was measured for 68 (79%) patients by the Brief Psychiatric Rating Scale, Global Assessment Scale, and Grip on Life. Results:- One-fourth of the patients experienced psychotic symptoms at follow-up. Sixty per-cent of the patients showed good global functioning and Grip on Life. In both patient groups, poor earlier global functioning, weak social network, poor Grip on Life, and psychological dependence on family of origin were associated with poor outcome. In the ...

2011-01-01

446

Synthesis characterization and biological evaluation of a novel mixed ligand "9"9"mTc complex as potential brain imaging agent

Radioguided occult lesion localization versus wire-guided localization for non-palpable breast lesions: randomized controlled trial

One approach in the design of neutral oxotechnetium complexes is based on the simultaneous substitution of a tridentate dianionic ligand and a monodentate monoanionic coligand on a [Tc(V)O]"+"3 precursor. Following this ''mixed ligand'' concept, a novel "9"9"mTc complex with N,N-bis(2-mercaptoethyl)-N'N'-diethylethylenediamine as ligand and 1-octanethiol as coligand is prepared and evaluated as potential brain radiopharmaceutical. Preparation of the complex at tracer level was accomplished by using "9"9"mTc-glucoheptonate as precursor. The substitution was optimized and a coligand/ligand ratio of 5 was selected. Under this conditions the labeling yield was over 80% and a major product (with radiochemical purity > 80%) was isolated by HPLC methods and used for biological evaluation. Chemical characterization at carrier level was developed using the corresponding rhenium complex as structural model. The Re complex was also prepared by substitution method and isolated as a crystalline ...

1998-08-01

447

Scientific Electronic Library Online (English)

Abstract in english AIM: This prospective randomized clinical study was conducted to compare radioguided occult lesion localization (ROLL) with wire-guided localization to evaluate optimum localization techniques for non-palpable breast lesions. METHODS: A total of 108 patients who were undergoing an excisional biopsy for non-palpable breast lesions requiring pathologic diagnosis were randomly assigned to the ROLL group (n = 56) and wire-guided localization group (n = 52). In the study, pati (more) ents' characteristics, radiological abnormalities, radiological technique of localization, localization time, operation time, weight of the excised specimen, clearance margins, pathological diagnosis and perioperative complications were assessed. RESULTS: There were no differences between the two groups in terms of age, radiological abnormalities and localization technique (p = non-significant for all). ROLL techniques resulted in 100% retrieval of the lesions; for the ...

2011-01-01

448

Preparation of a high specific activity I-125 labeled styryl dye for leukocyte membrane labeling

Novel bifunctional natriuretic peptides as potential therapeutics.

The purpose of this work was to develop a high specific activity radioiodinated cell membrane probe for tracking lymphocytes in-vivo to replace the nucleus localizing, cytotoxic lipophilic chelates (In-111 oxine and Tc-99m HMPAO) currently used. Alkylation of parent dye 4-[2-[-N,N-didecylamino]phenyl]ethenyl pyridine with E-1-tributylstannyl-3-tosylpropene (prepared form E-1-tributylstannyl-1-propene-3-ol), gave a tributyltin precursor 1. Radiolabeled 3-[4-[2-[4-(N,N-didecylamino)phenyl]ethenyl]pyridino] E-[I-125]-1-iodopropene (2), was prepared from 1 using peracetic acid in acetonitrile/water. Labeling yields and specific activities achieved were 26% (#approx#2170 Ci/mmol), 40% (1220 Ci/mmol), and 55% (200 Ci/mmol) for nca, 0.4, and 2 nanomole carrier iodide runs respectively. Canine mixed leukocytes (0.5-1.0 x 10"8 cells) were labeled with 2 (67% and 42% yields for 200 Ci/mol and 1220 Ci/mmol preparations) and showed blood clearance similar to In 111 oxine. ...

1994-08-21

449

Natriuretic peptides in vascular physiology and pathology.

Synthetic atrial natriuretic peptide (carperitide) and B-type natriuretic peptide (BNP; nesiritide) are used to treat congestive heart failure. However, despite beneficial cardiac unloading properties, reductions in renal perfusion pressures limit their clinical effectiveness. Recently, CD-NP, a chimeric peptide composed of C-type natriuretic peptide (CNP) fused to the C-terminal tail of Dendroaspis natriuretic peptide (DNP), was shown to be more glomerular filtration rate-enhancing than BNP in dogs. However, the molecular basis for the increased responsiveness was not determined. Here, we show that the DNP tail has a striking effect on CNP, converting it from a non-agonist to a partial agonist of natriuretic peptide receptor (NPR)-A while maintaining the ability to activate NPR-B. This effect is specific for human receptors because CD-NP was only a slightly better activator of rat NPR-A due to the promiscuous nature of CNP in this species. Interesting, the DNP tail alone had no effect ...

2008-10-21

450

Mucociliary transport and upper airway disease

Four major natriuretic peptides have been isolated: atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), C-type natriuretic peptide (CNP), and Dendroaspis-type natriuretic peptide (DNP). Natriuretic peptides play an important role in the regulation of cardiovascular homeostasis maintaining blood pressure and extracellular fluid volume. The classical endocrine effects of natriuretic peptides to modulate fluid and electrolyte balance and vascular smooth muscle tone are complemented by autocrine and paracrine actions that include regulation of coronary blood flow and, therefore, myocardial perfusion; modulation of proliferative responses during myocardial and vascular remodeling; and cytoprotective anti-ischemic effects. The actions of natriuretic peptides are mediated by the specific binding of these peptides to three cell surface receptors: type A natriuretic peptide receptor (NPR-A), type B natriuretic peptide receptor (NPR-B), and type C natriuretic peptide receptor ...

2008-01-01

451

Manufacture of IRDye800CW-coupled Fe3O4 nanoparticles and their applications in cell labeling and in vivo imaging

Mucociliary transport so critical in nasal, paranasal sinus, and middle ear physiology is impaired in chronic sinsusitis and otitis media by factors such as increased mucus viscoelasticity, decreased ciliary area, and primary or secondary ciliary immotility. We reviewed the pathophysiology of primary ciliary dyskinesia, otitis media with effusion, chronic sinusitis, and allergic rhinitis in terms of mucociliary transport. Subjects with primary ciliary dyskinesia may experience recurrent middle ear infection, chronic airway infection, predominantly lower-lobe bronchiectasis, male sterility, or situs inversus. Primary ciliary dyskinesia is sometimes difficult to diagnose in cases without situs inversus. Nasal nitric oxide concentration in such patients decreases, although why is unclear. Mutations may involve dynein arm intermediate chain 1 (DNAI1) or dynein arm heavy chain 5 (DNAH5). Mucociliary clearance decreases more in those with otitis media with effusion than ...

2010-05-01

452

Ionising radiation effects on food packaging

BackgroundIn recent years, near-infrared fluorescence (NIRF)-labeled iron nanoparticles have been synthesized and applied in a number of applications, including the labeling of human cells for monitoring the engraftment process, imaging tumors, sensoring the in vivo molecular environment surrounding nanoparticles and tracing their in vivo biodistribution. These studies demonstrate that NIRF-labeled iron nanoparticles provide an efficient probe for cell labeling. Furthermore, the in vivo imaging studies show excellent performance of the NIR fluorophores. However, there is a limited selection of NIRF-labeled iron nanoparticles with an optimal wavelength for imaging around 800 nm, where tissue autofluorescence is minimal. Therefore, it is necessary to develop additional alternative NIRF-labeled iron nanoparticles for application in this area.ResultsThis study manufactured 12-nm DMSA-coated Fe3O4 nanoparticles labeled with a near-infrared fluorophore, IRDye800CW (excitation/emission, ...

2010-10-29

453

Experimental studies of 6-inch pipe whip tests under BWR LOCA conditions

The main aim of any food irradiation treatment is to guarantee the best safe quality of the products, reducing the spreading risk ("cross-contamination") for several food-associated diseases. Actually, over 40 countries provide clearances for the treatment of about 45 different types of foodstuffs. EU has to homogenise the situation within the associated States. With the European directive 1999/2/EC Italy, as other EU countries, already has brought into force their regulations to comply. The current Italian regulation on irradiation treatment of foodstuffs is referred since 1996 as follows: a) potatoes, onions and garlic; b) spices, herbs and condiments microbial. The new (April 2001) Italian law allows the possibility to ask for special permission of treatment for other foodstuff which is possible to treat in other E.U. countries. Large majority of foods are submitted to irradiation treatment after they have been packaged. In Dutch cases the study of radiation ...

2001-10-22

454

Evaluation of critical heat flux of tight lattice core with subchannel analysis code NASCA

Series of pipe rupture tests have been performed at the Japan Atomic Energy Research Institute to demonstrate the safety of the primary coolant circuits in the event of pipe rupture in nuclear power plants. The pipe whip tests have been conducted to study the dynamic response of the pipe and restraints. The results of the pipe whip tests using test pipes of 4-inch in diameter under the BWR LOCA conditions (285"0C, 6.8 MPa) were reported in the previous paper F8/5 of the 6th SMiRT. The present paper describes the results of the pipe whip tests using test pipes of 6-inch in diameter. The test pipe was made of Type 304 stainless steel and was 165.2 mm in outer diameter and 11.0 mm in thickness, and was fixed at the pipe support so that the length of the test section was 3000 mm. The restraints were made of Type 304 stainless steel and were 16.0 mm in diameter, and were set on the restraint support with the clearance of 100 mm. The overhang length was 300 mm or 700 mm ...

455

Enzyme induction in neonates after fetal exposure to antiepileptic drugs

Reduced-Moderation Water reactor (RMWR) is a light water breeder reactor developed by Japan Atomic Energy Research Institute (JAERI). The RMWR comprises tight lattice fuel assemblies with gap clearance of around 1.0 mm to reduce water volume ratio to achieve a high conversion ratio. It is important to estimate the thermal hydraulic safety margin of the tight lattice core of the RMWR. In the present study, the boiling transition (BT) prediction performance of the subchannel analysis code NASCA developed for the current BWR cores was assessed for series of tight lattice critical heat flux (CHF) experiments performed in JAERI. The test section was a 7-rod bundle with rod diameter of 12.3 mm, rod gap of 1.0 mm and heated length of 1.8m. Axial power distribution was flat. With a simple subchannel model, the code overestimates the critical power in the high mass velocity region, although the predicted critical powers in the low mass velocity region were in good agreement ...

2003-04-20

456

Distributions of "1"3"7Cs, "2"0"1T1, "2"0"3Hg, "2"0"3Pb and "5"7Co in a rat hepatoma model. Comparison with "6"7Ga

The /sup 13/C-AP breath test is shown to be a convenient, noninvasive method to monitor velocity and capacity of P450-dependent AP N-demethylation in infancy and childhood. According to /sup 13/C-AP breath tests, neonates have a very low capacity to eliminate /sup 13/CO/sub 2/, which is only 15 to 21% of the activity in adults. During the first year of life AP N-demethylation increases to reach its maximum at about 2 years; afterwards a slight decrease occurs. In 25 neonates exposed prenatally to different antiepileptic drugs /sup 13/C-AP breath test was efficiently used to prove that cytochrome AP N-demethylation was considerably stimulated. After primidone/phenobarbitone, especially in combination with phenytoin, /sup 13/C elimination reaches and even surpasses the range for older children. Valproate exposure during fetal life is not consistently followed by a significant increase in AP N-demethylation. The enzyme induction demonstrated by /sup 13/C-AP breath test was often ...

1983-01-01

457

Diabetic patients have abnormal cerebral autoregulation during cardiopulmonary bypass

The distribution of carrier-free "2"0"3Pb-acetate, "2"0"3HgCl_2, "5"7Cocl_2, "1"3"7CsCl and "2"0"1TlCl was investigated in rats bearing thigh-implanted Morris 7777 hepatomas. Viable and nonviable tumor tissue was collected in order to determine the relative affinities of the radiopharmaceutical for these tissues. The animals were sacrificed at 4, 24, 48, 72 and 96 hrs following intravenous injection. Washout of the radioisotope from the viable tumor tissue was rapid, the maximum concentration being reached on or before 4 hrs following injection. In contrast, residual activity within the nonviable tumor tissue decreased much more slowly and in some cases even increased with time. Viable tumor-to-muscle and nonvialbe tumor-to-muscle ratios for "2"0"3Pb, "2"0"3Hg and "5"7Co were comparable to the analogous ratios reported for "6"7Ga. However, none of these isotopes approached "6"7Ga as a potential tumor imaging agent because the large ratios were the result of low muscle uptake rather ...

458

Development of a new radiolabel (lead-203) and new chelating agents for labeling monoclonal anntibodies for imaging

We tested the hypothesis that insulin-dependent diabetic patients with coronary artery bypass graft surgery experience altered coupling of cerebral blood flow and oxygen consumption. In a study of 23 patients (11 diabetics and 12 age-matched controls), cerebral blood flow was measured using 133Xe clearance during nonpulsatile, alpha-stat blood gas managed cardiopulmonary bypass at the conditions of hypothermia and normothermia. In diabetic patients, the cerebral blood flow at 26.6 +/- 2.42 degrees C was 25.3 +/- 14.34 ml/100 g/min and at 36.9 +/- 0.58 degrees C it was 27.3 +/- 7.40 ml/100 g/min (p = NS). The control patients increased cerebral blood flow from 20.7 +/- 6.78 ml/100 g/min at 28.4 +/- 2.81 degrees C to 37.6 +/- 8.81 ml/100 g/min at 36.5 +/- 0.45 degrees C (p less than or equal to 0.005). The oxygen consumption was calculated from jugular bulb effluent and increased from hypothermic values of 0.52 +/- 0.20 ml/100 g/min in diabetics to 1.26 +/- 0.28 ...

1990-11-01

459

Decreased duration of pentobarbital-induced narcosis in immature and adult female rats prenatally exposed to cimetidine

High liver uptake and slow body clearance presently limit the usefulness of "1"1"1In labeled antibodies for tumor imaging. We have investigated "2"0"3Pb as an alternate and better antibody label. The DTPA and cyclohexyl EDTA (CDTA) conjugates of an anticolon carcinoma antibody, 17-1A were labeled (bicyclic anhydride method) with "2"0"3Pb and "1"1"1In with 60 and 90% labeling yields, respectively. The biodistribution of "2"0"3Pb-17-1A conjugates was compared with the corresponding "1"1"1In-labeled preparations and with "2"0"3Pb-DTPA, "2"0"3Pb-nitrate and nonrelevant antibody controls in normal and human tumor (SW948) xenografted nude mice at 24, and 96 hr. Lead-203-labeled CDTA and DTPA antibody conjugates gave similar in vivo distributions. Even though the lead bound to these chelate-antibody conjugates was more labile in serum and in vivo, compared to indium, it cleared much faster from the liver and the whole body. A new series of chelating agents based on the ...

1988-05-22

460

Damages of mountings in HP- and MP-turbines; Schaeden an Vierzacken-Schaufelfuessen in HD- und MD-Turbinen

The effect of prenatal cimetidine exposure (PreCM) on the duration of pentobarbital-induced narcosis (DPN) was assessed in immature (14- and 28-day old) and adult (50-60-day old) male and female rats. PreCM exposure was accomplished by treating mothers with cimetidine (CM) (20 mg/kg, ip) daily for the last two days of gestation and then (0.01% in drinking water) throughout lactation. Pregnant mothers of untreated offspring (Con) received saline. PreCM decreased DPN to 505 +/- 33 min (from 611 +/- 23 min in Con) and 393 +/- 190 min (from 686 +/- 44 min in Con) in 14-day old male and female rats, respectively. Similarly, PreCM decreased DPN to 88 +/- 15 min (from 134 +/- 3 min in Con) and 102 +/- 19 min (from 171 +/- 44 min in Con) in 28-day old male and female rats, respectively. At 21 days, PreCM did not alter DPN in either sex. At 50-60 days, however, it decreased DPN to 144 +/- 41 min (from 238 +/- 7 min in Con) in females but had no effect in males; PreCM also increased the plasma ...

1986-03-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

461

Biokinetic and dosimetric studies of {sup 188}Re-hyaluronic acid: a new radiopharmaceutical for treatment of hepatocellular carcinoma

Investigation of an HP-blade damage in 1996 and an MP-blade damage in 1007 at the mounting showed that fretting and creep fatigue had caused the damage. Break-down occurred when creep-related cracks developed between radial bridge to the upper blade tooth and weight relief boreholes. After disassembly of the HP-blades the lower blade tooth was found to be cracked after fretting (some cracks along the whole length of the tooth). The lower teeth of MP-bladedes showed merely superficial cracks (depth about 0.4mm). The massive cracks of the lower blade tooth were caused by instationary clearance changes combined with hard blade underground.(orig.) [German] Das Ergebnis der Untersuchung nach einem HD-Schaufelschaden 1996 sowie einem MD-Schaufelschaden 1997 an der Vierzackenfussbefestigung ergab Zeitstanderschoepfung und Fretting als auszuloesende Schadensmechanismen. Die Havarien wurden durch zeitstandbedingte Brueche zwischen Radienuebergang zum oberen Schaufelzacken ...

1998-07-01

462

A stable neurotensin-based radiopharmaceutical for targeted imaging and therapy of neurotensin receptor-positive tumours

Hepatocellular carcinoma (HCC) is the most common primary liver cancer and has very limited therapeutic options. Recently, it has been found that hyaluronic acid (HA) shows selective binding to CD44 receptors expressed in most cancer histotypes. Since the trend in cancer treatment is the use of targeted radionuclide therapy, the aim of this research was to label HA with rhenium-188 and to evaluate its potential use as a hepatocarcinoma therapeutic radiopharmaceutical. Methods: {sup 188}Re-HA was prepared by a direct labelling method to produce a ReO(O-COO){sub 2}-type coordination complex. {sup 188}Re-HA protein binding and its stability in saline, phosphate buffer, human serum and cysteine solutions were determined. Biokinetic and dosimetric data were estimated in healthy mice (n=60) using the Medical Internal Radiation Dose methodology and mouse model beta-absorbed fractions. To evaluate liver toxicity, alanine aminotranferase (AST) and aspartate aminotranferase (ALT) levels in mice ...

2009-08-15

463

A case of wound intake of plutonium isotopes and 241Am in a human: application and improvement of the NCRP wound model.

Neurotensin (NT) and its high affinity receptor (NTR1) are involved in several neoplastic processes. Thus, NT-based radiopharmaceuticals are potential tracers for targeted diagnosis and therapy of NTR-positive tumours. A new analogue based on NT(8-13), NT-XIX, with the three enzymatic cleavage sites stabilised, was synthesised and tested. The synthesis was performed by Boc strategy. Labelling with "9"9"mTc/"1"8"8Re was performed using the tricarbonyl technique. Metabolic stability was tested in vitro and in vivo. NT-XIX was further characterised in vitro in HT-29 cells and in vivo in nude mice with HT-29 xenografts. NT-XIX showed much longer half-lives than non-stabilised analogues. Binding to NTR1 was highly specific, although the affinity was lower than that of natural NT. Bound activity rapidly internalised into HT-29 cells and 50% remained trapped after 24 h. In the time-course biodistribution, the highest uptake was found in the tumour at all p.i. times. In vivo uptake was ...

2009-01-01

464

Relationship of DNA repair processes to mutagenesis and carcinogenesis in mammalian cells. Progress report, November 1, 1979-October 31, 1980

Plutonium isotopes (239Pu and 238Pu, and 241Am) with a total activity of 269 kBq were accidentally deposited in a puncture wound of the right index finger of a nuclear worker at the Mayak Production Association. Tissues surrounding the wound site contaminated with radionuclides were excised 4.5 h after the injury. Residual contamination within the wound amounted to 0.05% of the initial contamination. The 10-d therapy with CaNa3-diethylene triamine pentaacetate acid (CaNa3-DTPA) was performed in parallel with in vivo measurements of the wound site and daily urine bioassays. The wound intake of radionuclides was consistent with two forms of radioactive materials detected within the wound site, i.e., soluble compounds and a large fragment, which was completely removed by excision. On day 9 after the injury, the clearance rate from the wound site was 1.8 times higher than the rate predicted by the National Council on Radiation Protection and Measurements (NCRP) model ...

2010-10-01

465

Production of Infectious Genotype 1b Virus Particles in Cell Culture and Impairment by Replication Enhancing Mutations

The objective of this research is to determine the role of DNA repair in mutagenesis and carcinogenesis in mammalian cells. Use of the host-cell reactivation viral suicide enrichment procedure was initiated in the isolation of repair-deficient mutants. Lightly mutagenized BHK cells were infected with irradiated Herpes simplex virus (HSV); several radiation-sensitive strains were isolated among the survivors of the infection. The characterization of these strains is progressing and the enrichments are continuing. That alterations in the frequency of mutation of C3H/10T 1/2 cells, occurring as a result of holding the cells in a confluent state following treatment with ethylmethane sulfonate, parallel the alterations in the frequency of neoplastic transformation was found. The repair capabilities of BHK cells were found to be intermediate in comparison to repair-proficient and -deficient human cells with regard to the reactivation of HSV treated with various ...

466

Effective use of optimized, high-dose (50 kGy) gamma irradiation for pathogen inactivation of human bone allografts.

With the advent of subgenomic hepatitis C virus (HCV) replicons, studies of the intracellular steps of the viral replication cycle became possible. These RNAs are capable of self-amplification in cultured human hepatoma cells, but save for the genotype 2a isolate JFH-1, efficient replication of these HCV RNAs requires replication enhancing mutations (REMs), previously also called cell culture adaptive mutations. These mutations cluster primarily in the central region of non-structural protein 5A (NS5A), but may also reside in the NS3 helicase domain or at a distinct position in NS4B. Most efficient replication has been achieved by combining REMs residing in NS3 with distinct REMs located in NS4B or NS5A. However, in spite of efficient replication of HCV genomes containing such mutations, they do not support production of infectious virus particles. By using the genotype 1b isolate Con1, in this study we show that REMs interfere with HCV assembly. Strongest ...

2009-06-12

467

Depuration of shellfish by irradiation: Final technical report, October 1, 1987--March 31, 1989

The safety of tissue allografts has come under increased scrutiny due to recent reports of allograft-associated bacterial and viral infections in tissue recipients. We report that 50 kGy of gamma irradiation, nearly three times the dose currently used, is an effective pathogen inactivation method when used under optimized conditions that minimize damage to the tissue. Cancellous bone dowels treated with a radioprotectant solution and 50 kGy of optimized irradiation had an ultimate compressive strength and modulus of elasticity equal to conventionally irradiated (18 kGy) and non-irradiated control bone grafts. We subjected bone dowels treated with this pathogen inactivation method to an in vitro cytotoxicity test using three different mammalian cell lines and concluded that the treated grafts were not cytotoxic. The log reduction of nine pathogens spiked into radioprotectant-treated bone irradiated to 50 kGy was also tested. We achieved 4.9 logs of inactivation of a ...

2005-05-01

468

Antitumor and Antiviral Activity of Colombian Medicinal Plant Extracts

Studies by the University of Lowell Radiation Laboratory and the US National Marine Fisheries Service N.E. Laboratory in Gloucester, MA on softshelled clams (Mya arenaria) demonstrated the effectiveness of low to medium doses of Cobalt 60 source gamma irradiation in the inactivation of Escherichia coli, Salmonella typhimurium, Staphylococcus aureus and Streptococcus faecalis. Post-irradiation survival and organoleptic studies when extended to hardshelled clams (Mercinaria mercenaria) and American oysters (Crassostrea virginica) showed no significant decline in consumer qualities or 6 day post irradiation survival in oysters at doses of up to 3.0 kGy. The capacities of the American oyster to sustain relatively high doses of gamma irradiation were demonstrated by 6 day post-exposure survivorship values of greater than 90% for samples receiving 3.0, 5.0 and 7.0 kGy. Initial studies of inactivation of Polio I virus and a simian rotavirus (SA-11) was conducted in both hardshelled clams and ...

469

Scientific Electronic Library Online (English)

Abstract in english Extracts of nine species of plants traditionally used in Colombia for the treatment of a variety of diseases were tested in vitro for their potential antitumor (cytotoxicity) and antiherpetic activity. MTT (Tetrazolium blue) and Neutral Red colorimetric assays were used to evaluate the reduction of viability of cell cultures in presence and absence of the extracts. MTT was also used to evaluate the effects of the extracts on the lytic activity of herpes simplex virus type (more) 2 (HSV-2). The 50% cytotoxic concentration (CC50) and the 50% inhibitory concentration of the viral effect (EC50) for each extract were calculated by linear regression analysis. Extracts from Annona muricata, A. cherimolia and Rollinia membranacea, known for their cytotoxicity were used as positive controls. Likewise, acyclovir and heparin were used as positive controls of antiherpetic activity. Methanolic extract from Annona sp. on HEp-2 cells presented a CC50 value at ...

1999-07-01

470

Thin Wall Iron Castings

The Philadelphia Marriott: A convention center flagship hotel

Results of an investigation made to develop methods of making iron castings having wall thicknesses as small as 2.5 mm in green sand molds are presented. It was found that thin wall ductile and compacted graphite iron castings can be made and have properties consistent with heavier castings. Green sand molding variables that affect casting dimensions were also identified.

2001-10-31

471

Stein method for invariant measures of diffusions via Malliavin calculus

This article describes the state-of-the-art HVAC system at the Philadelphia Marriott Hotel. Thermal comfort and indoor air quality are emphasized. The system uses a hybrid gas absorption/electric centrifugal chilled water plant, variable flow pumping, water-side economizers to provide free cooling, central air handling units with air-side economizers and flow monitoring equipment.

1997-01-01

472

Given a random variable $F$ regular enough in the sense of the Malliavin calculus, we are able to measure the distance between its law and almost any continuous probability law on the real line. The bounds are given in terms of the Malliavin derivative of $F$. Our approach is based on the theory of It\\^o diffusions and the stochastic calculus of variations. Several examples are considered in order to illustrate our general results.

2011-01-01

473

Solar astrophysics

Process optimization for saccharification of cellulose by acid hydrolysis

This book comprises an up-to-date description of the astrophysical characteristics of the sun, including modern techniques used in solar research. Provides an historical background of solar research and techniques and covers the necessary astrophysics for solar studies, energy generation in the interior, the convection zone, the non- thermally heated layers, and solar wind are described in detail. Also considers the sun in relation to other stars, including information on its variable outputs of light, charged particles, and fields.

1990-01-01

474

Problems of the radiometric level measurement in large bins

Cellulose raw materials costs must be considered in order to obtain a minimized hexose cost. In recognition of this fact, it may be economically advantageous to operate at less than maximum hexose concentration in the reactor and to recycle unreacted cellulose. The objective of this article is to optimize a cellulose-recycle reactor system for producing hexose at minimum cost. A sensitivity analysis of the important variables in the mathematical model of this system is also discussed.

1980-01-01

475

Physical therapy applications of MR fluids and intelligent control

After a brief survey of the known level measurement methods the particularities of the radiometric measurement of the still utilisable residual volume of a bulk material in a large bin are discussed. At constant angle of repose the measurement in a suitably positioned plane of measurement suffices, at variable angle of repose two planes of measurement are required. The probable working ranges for a 1300-t lime bin are estimated.

1984-01-01

476

Petroleum waxes in solvent systems

Resistance exercise has been widely reported to have positive rehabilitation effects for patients with neuromuscular and orthopaedic conditions. This paper presents an optimal design of magneto-rheological fluid dampers for variable resistance exercise devices. Adaptive controls for regulating the resistive force or torque of the device as well as the joint motion are presented. The device provides both isometric and isokinetic strength training for various human joints.

2005-05-01

477

Optimal choice of cupola furnace nominal operating point

Wax appearance temperature (WAT) of three petroleum waxes in different solvent systems under varying thermal conditions has been determined. It is observed that this temperature mainly is a function of the concentration of the wax and the solubility parameter ([delta]) of the solvent taken. This dependence of WAT has been quantified in terms of these variables in the form of mathematical equation and nomographs. (orig.)

1994-01-01

478

Multidipole magnetic fields for plasma confinement

One of the main goals in the operation of a cupola furnace is to keep the molten iron properties within prescribed bounds while maintaining the most economical operation for the cupola. In this paper the authors present a procedure to obtain the nominal values for the manipulated process variables. The nominal values are calculated by solving a constrained nonlinear programming optimization problem. Two different optimization problems are discussed and examples for using the procedure are presented.

1998-08-01

479

Mathematical two-dimensional model for three-phase filtering of compressible fluids

Plasma confinement by permanent magnets has been studied. An analytic formula for the field of a single bar magnet has been obtained. Generalization to various configurations of multidipole fields has also been found. Any two-dimensional field may now be completely described by a simple function of complex variables in closed form. Vector potential has also been obtained by integrating over a prescribed Riemann surface. The confinement of plasma by multidipole fields then becomes obvious through conservation principles.

1983-07-01

480

MACHO observations of Type II cepheids and RV Tauri Stars in the LMC

A mathematical model is proposed for three-phase filtering which is a particular case of a more general model of filtering multiple component mixtures and makes it possible to describe three-phase filtering flows under conditions where the pressure of saturation is variable in time and in space. In the proposed model, the system of unknown functions is selected so that it makes it possible to trace fairly simply the pressure of saturation and to compute the corresponding equation coefficients.

1982-01-01

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481

Long-range correlation analysis of earthquake-related geochemical variations recorded in Central Italy

We report the of the existence of RV Tauri stars in the Large Magellanic Cloud (LMC). This class of variable star has hitherto been unidentified in the Magellanic Clouds. In light and color curve behavior the RV Tauri stars appear to be an extension of the Type II Cepheids to longer periods. A single period-luminosity-color relationship is seen to describe both the Type II Cepheids and the RV Tauri stars in the LMC.

1996-07-01

482

Integrability and symmetric spaces

The long-range correlation properties in the hourly time variability of geochemical signals measured in a 70 m depth well at Triponzo (Umbria region), are investigated by the detrended fluctuation analysis (DFA). DFA is a data processing method that allows for the detection of scaling behaviors in observational time series even in the presence of non-stationarities. The procedure adopted has allowed for the unambiguous identification of possible correlations among the recorded signals and local earthquakes.

2004-07-01

483

Infinitesimal symmetries and conservation laws of the DNLSE hierarchy and the Noether's theorem

It is shown that a sufficient condition for a model describing the motion of a particle on a coset space to possess a Fundamental Poisson bracket Relation, and consequently charges in involution, is that it must be a symmetric space. The conditions, a Hamiltonian, or any functions of the canonical variables, has to satisfy in order to commute with these charges, are studied. It is show that, for the case of the noncompact symmetric spaces, these conditions lead to an algebraic structure which lays an important role in the construction of conserved quantities.

1989-01-01

484

Haplotyping and copy number estimation of the highly polymorphic human beta-defensin locus on 8p23 by 454 amplicon sequencing

The hierarchy of integrable nonlinear equations associated with the quadratic bundle is considered. The expressions for the solution of linearization of these equations and their conservation law in the terms of solutions of corresponding Lax pairs are found. It is shown for the first member of the hierarchy that the conservation law is connected with the solution of linearized equation due to the Noether's theorem. The local hierarchy and three nonlocal ones of the infinitesimal symmetries and conservation laws explicitly expressed through the variables of the nonlinear equations are derived. (author)

2007-08-15

485

Fuzzy risk analysis for safeguards and network security

BackgroundThe beta-defensin gene cluster (DEFB) at chromosome 8p23.1 is one of the most copy number (CN) variable regions of the human genome. Whereas individual DEFB CNs have been...Full Text Available

486

Evolution of a horizontal branch Population II star with total mass 0.63 Msub solar

Analyzing the risk of a safeguards system, in particular the security of a computer network based on the notion of fuzzy sets and linguistic variables, addresses concerns such as complexity and inherent imprecision in estimating the possibility of loss or compromise. Automated risk analysis allows the risk to be determined for an entire system based on estimates for lowest level components and the component weight. In addition, for each component (asset) we select the most effective combination of protection mechanisms against a given set of threats.

1992-01-01

487

Entangling optical and microwave cavity modes by means of a nanomechanical resonator

The theoretical evolution of a horizontal branch star of Population II is followed through the helium burning in the core phase and is compared with the results given by other investigators. The m- fluence of different physics and interpolation schemes in the opacity tables is discussed. Some thoughts are given on the explanation of the erratic period variations observed in some of the RR Lyrae variables in the globular clusters. (auth)

1973-01-01

488

Energy efficient fuzzy based combined variable refrigerant volume and variable air volume air conditioning system for buildings

We propose a scheme able to generate stationary continuous variable entanglement between an optical and a microwave cavity mode by means of their common interaction with a micro-mechanical resonator. We show that when both cavities are intensely driven one can generate bipartite entanglement between any pair of the tripartite system, and that, due to entanglement sharing, optical-microwave entanglement is efficiently generated at the expense of microwave-mechanical and opto-mechanical entanglement.

2011-01-01

489

Effects of several variables on whole effluent toxicity test performance and interpretation

Energy conservative building design has triggered greater interests in developing flexible and sophisticated air conditioning systems capable of achieving enhanced energy-savings potential without sacrificing the desired thermal comfort and indoor air quality (IAQ). This research work greatly aimed at achieving enhanced energy conservation, good thermal comfort and better IAQ for space conditioning with the application of combined variable refrigerant volume (VRV) and variable air volume (VAV) air conditioning (A/C) systems. Experimental investigation on the proposed combined air conditioning system with the application of intelligent fuzzy logic controller was performed for summer and winter climatic conditions to substantiate the energy-savings capability. The proposed system experimentally analyzed under fixed ventilation, demand controlled ventilation (DCV) and combined DCV and economizer cycle (EC) ventilation techniques effectively ...

2010-04-15

490

Effect of environmental variables on localized corrosion of high-performance container materials

Protocol changes and options contained within US Environmental Protection Agency whole effluent toxicity tests represent variables that have the potential to affect bioassay performance and interpretation of results. Variables evaluated in this study include: the change in allowable age in the Pimephales promelas acute bioassay from up to 90 d to a maximum of 14 d, age-specific acute responses of P. promelas among the allowable ages of 1 to 14 d, change in the chronic growth endpoint definition from final mass to biomass, differences between hemacytometer and fluorometer measurements in the Selenastrum capricornutum protocol, and options for statistical interpretation of species sensitivity in multiple test/species screening bioassays. Clear age-related sensitivity and precision differences were observed in acute responses of P. promelas. Results obtained using the younger age classes were typically more variable in studies ...

2000-01-01

491

Dynamics of Axial Separation in Long Rotating Drums

Electrochemical cyclic potentiodynamic polarization (CPP) experiments were performed on several candidate high-performance waste package container materials to evaluate their susceptibility to localized corrosion in aqueous environments relevant to the potential underground high-level nuclear waste repository. This paper presents the results of this study showing the effects of chloride ion (Cl) concentrations, pH, temperature, and electrochemical potential scan rate on the pitting corrosion behavior of these materials.

1997-01-01

492

Discordant expression and variable numbers of neighboring GGA- and GAA-rich triplet repeats in the 3' untranslated regions of two groups of messenger RNAs encoded by the rat polymeric immunoglobulin receptor gene.

We propose a continuum description for the axial separation of granular materials in a long rotating drum. The model, operating with two local variables, concentration difference and the dynamic angle of repose, describes both initial transient traveling wave dynamics and long-term segregation of the binary mixture. Segregation proceeds through ultraslow logarithmic coarsening. {copyright} {ital 1999} {ital The American Physical Society}

1999-06-01

493

Differential decay of parent-of-origin-specific genomic sharing in cystic fibrosis-affected sib pairs maps a paternally imprinted locus to 7q34

An unusual S1-nuclease sensitive microsatellite (STMS) has been found in the single copy, rat polymeric immunoglobulin receptor gene (PIGR) terminal exon. In Fisher rats, elements within or beyond the...Full Text Available

1995-04-11

494

Crop improvement of field vegetables

Cystic fibrosis (CF) is a monogenic disease characterized by a high variability of disease severity and outcome that points to the role of environmental factors and modulating genes that shape the course...Full Text Available

2010-05-01

495

Environmental Research Database

DescriptionThe main objective of the project is to develop a range of underpinning plant resources together with information about the level of genetic variability they represent, in a form suitable for use in crop improvement research in vegetable brassicas, lettuce and onion. The proposed research addresses Defra's requirement for a crop improvement programme to underpin research programmes aimed at Pest and Disease Control, Plant Nutrition and Quality in field vegetables at HRI. We will produc [continued...

2009-01-31

496

Conventional and unconventional political participation

Computer modeling in the design and evaluation of electric and hybrid vehicles

A non-recursive model is proposed and empirically tested with data of opponents of nuclear power. In explaining conventional and unconventional participation the theory of collective action is applied and modified in two respects: the perceived influence on the elimination of collective evils are taken into account; the selective incentives considered are non-material ones. These modifications proved to be valid: the collective good variables and non-material incentives were important determinants for the two forms of participation. Another result was that there is a reciprocal causal relationship between conventional and unconventional participation.

1985-01-01

497

Canonical Gravity with Fermions

This demonstration project uses modern simulation techniques to illustrate the important technologies and design variables that an auto-designer would consider in production a high efficiency, low emissions vehicle. Simulation and modeling techniques use the idea of capturing the relationships between real components of the systems with mathematical equations. These equations are then solved on a computer to simulate the behavior or performance of the system under various conditions. In the current demonstration project, we focus on many variations of a hydrogen-powered vehicle.

1996-08-16

498

Application of artificial neural network to direct coal liquefaction research

Canonical gravity in real Ashtekar-Barbero variables is generalized to allow for fermionic matter. The resulting torsion changes several expressions in Holst's original vacuum analysis, which are explicitly displayed here. This in turn requires adaptations to the known canonical (loop) quantization of gravity coupled to fermions, which is discussed on the basis of the classical analysis.

2007-01-01

499

AMMONIA ABSORPTION/AMMONIUM BISULFATE REGENERATION PILOT PLANT FOR FLUE GAS DESULFURIZATION

The catalytic liquefaction of a Chinese bituminous coal was simulated by artificial neural network. Three liquefaction variables, catalyst loading, reaction temperature and reaction time were used as inputs and tetrohydrofuran (THF) conversion and toluene (T) conversion were used as outputs. The artificial neural network, trained by the experimental data, could represent the liquefaction process, with a mean squared deviation of less than 0.025. 7 refs.,1 fig., 3 tabs.

1998-07-01

500