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Current studies in plants suggest that the content of the coenzyme NAD is variable and potentially important in determining cell fate. In cases that implicate NAD consumption, re-synthesis must occur to maintain dinucleotide pools. Despite information on the pathways involved in NAD synthesis in plants, the existence of a mitochondrial nicotinamide mononucleotide adenylyltransferase (NMNAT) activity which catalyses NAD synthesis from nicotinamide mononucleotide (NMN) and ATP has not been reported. To verify the latter assumed pathway, experiments with purified and bioenergetically active mitochondria prepared from tubers of Jerusalem artichoke (Helianthus tuberosus L.) were performed. To determine whether NAD biosynthesis might occur, NMN was added to Jerusalem artichoke mitochondria (JAM)...

UK PubMed Central (United Kingdom)

BackgroundBacterial constituents, such as Gram-negative derived lipopolysaccharide (LPS), can initiate inflammatory bone loss through induction of host-derived inflammatory...Full Text Available

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The biosynthesis of insect juvenile hormone (JH) and its neuroendocrine control are attractive targets for chemical control of insect pests and vectors of disease. To facilitate the molecular...Full Text Available

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Pathways of salicylic acid (SA) biosynthesis and metabolism in tobacco have been recently identified. SA, an endogenous regulator of disease resistance, is a product of phenylpropanoid metabolism formed...Full Text Available

UK PubMed Central (United Kingdom)

Studies of the antigenic structure of the polysaccharide component of gonococcal lipopolysaccaride (LPS) indicated that the non-serogroup antigen structure is antigenically heterogeneous. Immunodiffusion...Full Text Available

UK PubMed Central (United Kingdom)

The effects of an electric current on ethylene biosynthesis were investigated in cucumber (Cucumis sativus L.) fruit that were producing almost no ethylene. Direct currents at 0.5...Full Text Available

UK PubMed Central (United Kingdom)

A cell-free system which catalyzes the biosynthesis of terpene hydrocarbons when supplemented with mevalonate, Mn²⁺, and ATP was prepared from the scutellum-embryonic axis region of maize...Full Text Available

UK PubMed Central (United Kingdom)

Biosynthesis and uptake of siderophores in Aspergillus nidulans are regulated not only by iron availability but also by ambient pH: expression of this high-affinity iron uptake system...Full Text Available

UK PubMed Central (United Kingdom)

Leaves of terrestrial plants are aerobic organs, and are not usually considered to possess the enzymes necessary for biosynthesis of ethanol, a product of anaerobic fermentation. We examined the ability...Full Text Available

International Science & Technology Center (ISTC)

Studies of the Superheavy-metal Effect as a Stress-factor on Protein Biosynthesis and Cytoskeleton Integrity in Animal Cells

UK PubMed Central (United Kingdom)

Cleavage of membrane-associated proteins with the release of biologically active macromolecules is an emerging theme in biology. However, little is known about the nature and regulation of the involved...Full Text Available

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BackgroundLipocalin 2 (Lcn2) is a bacteriostatic factor that may also modulate cellular function, however, little is known concerning the expression or role of Lcn2 in CNS inflammation....Full Text Available

UK PubMed Central (United Kingdom)

The objective of this study was to develop a specific immunological diagnostic assay for yellow disease in hyacinths, using monoclonal antibodies (MAbs). Mice were immunized with a crude cell wall preparation...Full Text Available

UK PubMed Central (United Kingdom)

Escherichia coli infection of the endometrium causes uterine disease after parturition and is associated with prolonged luteal phases of the ovarian cycle in cattle. Termination...Full Text Available

International Nuclear Information System (INIS)

Biosynthesis of hemoglobin and some of its electrophoretic fractions in red cells of peripheral blood and spleen of irradiated (650 R) rats has been studied. Hemoglobin synthesis is found to be most drastically inhibited in the first and second fractions on the first and eighth days after irradiation and in the fifth and sixth fractions on the eighth day (less expressed). The synthesis is restored on the twelfth day, the process under study proceeding more slowly in the above-mentioned fractions than in others. In the course of radiation sickness, the biosynthesis of certain hemoglobin fractions varies differently in the hemoglobin-synthesizing cells of peripheral blood than in the cells of spleenic erythroid series.

International Nuclear Information System (INIS)

English 2008 p. 216 Poland Zalewski, K. Nitkiewicz, B. Department of

British Library Electronic Table of Contents (United Kingdom)

Ethnopharmacological relevance: Extracts of the roots of Scutellaria baicalensis Georgi (Labiatae) have been widely used to relieve fever related to bacterial infection and inflammatory diseases in traditional Korean medicine and have been reported to be effective in brain diseases. These experiments were conducted to examine the effects of oral administration of Scutellaria baicalensis extracts on the rescue of memory impairments induced by chronic cerebral hypoperfusion or chronic lipopolysaccharide (LPS) infusion. In addition, the underlying mechanisms of these effects were investigated. Materials and methods: In the first experiment, chronic cerebral hypoperfusion was induced in male Wister rats by bilateral common carotid artery occlusion (BCCAo). Daily administration of Scutellaria b...

UK PubMed Central (United Kingdom)

MauG is a novel 42 kDa di-heme protein which is required for the biosynthesis of tryptophan tryptophylquinone, the prosthetic group of methylamine dehydrogenase. The visible absorption and resonance...Full Text Available

UK PubMed Central (United Kingdom)

Fatty acid biosynthesis from Na[1-¹⁴C]acetate was characterized in plastids isolated from primary roots of 7-day-old germinating pea (Pisum sativum L.) seeds. Fatty acid...Full Text Available

UK PubMed Central (United Kingdom)

In monocytes, sulfatide, a lipid from Mycobacterium tuberculosis, blocked priming for enhanced release of superoxide (O2-) by the macrophage activating factors lipopolysaccharide, gamma interferon,...Full Text Available

International Nuclear Information System (INIS)

["1"4C]Cadaverine was applied to leaves of Lupinus polyphyllus, L. albus, L. angustifolius, L. perennis, L. mutabilis, L. pubescens, and L. hartwegii and it was preferentially incorporated into lupanine. In Lupinus arboreus sparteine was the main labelled alkaloid, in L. hispanicus it was lupanine. A pulse chase experiment with L. angustifolius and L. arboreus showed that the incorporation of cadaverine into lupanine and sparteine was transient with a maximum between 8 and 20 h. Only leaflets and chlorophyllous petioles showed active alkaloid biosynthesis, whereas no incorporation of cadaverine into lupanine was observed in roots. Using in vitro organ cultures of Lupinus polyphyllus, L. succulentus, L. subcarnosus, Cytisus scoparius and Laburnum anagyroides the inactivity of roots was confirmed. Therefore, the green aerial parts are the major site of alkaloid biosynthesis in lupins and in other legumes. (orig.).

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When autotrophically growing cultures of Chlorella are treated with levulinic acid, δ-aminolevulinic acid is excreted into the medium, providing a direct demonstration of α-aminolevulinic...Full Text Available

UK PubMed Central (United Kingdom)

URA5 genes encode orotidine-5′-monophosphate pyrophosphorylase (OMPpase), an enzyme involved in pyrimidine biosynthesis. We cloned the Histoplasma capsulatum URA5...Full Text Available

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Mycolic acids are key cell wall components for the survival, pathogenicity, and antibiotic resistance of the human tubercle bacillus. Although it was thought that Mycobacterium tuberculosis...Full Text Available

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All molybdoenzyme activities are absent in chlB mutants because of their inability to synthesize molybdopterin guanine dinucleotide, which together with molybdate constitutes the molybdenum cofactor...Full Text Available

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Norway spruce (Picea abies L. Karst) produces an oleoresin characterized by a diverse array of terpenoids, monoterpenoids, sesquiterpenoids, and diterpene resin acids that can protect...Full Text Available

UK PubMed Central (United Kingdom)

Salicylic acid (SA) is an important component of systemic-acquired resistance in plants. It is synthesized from benzoic acid (BA) as part of the phenylpropanoid pathway. Benzaldehyde (BD), a potential...Full Text Available

UK PubMed Central (United Kingdom)

The hyaluronic acid capsule of Streptococcus uberis has been implicated in conferring resistance to phagocytosis by bovine neutrophils. Construction of a bank of random insertion mutants...Full Text Available

UK PubMed Central (United Kingdom)

Moenomycin A (MmA) belongs to a family of natural products that inhibit peptidoglycan biosynthesis by binding to the peptidoglycan glycosyltransferases (PGTs), the enzymes that make the glycan...Full Text Available

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BackgroundAs the first pathway-specific enzyme in carotenoid biosynthesis, phytoene synthase (PSY) is a prime regulatory target. This includes a number of biotechnological approaches...Full Text Available

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Tooth enamel biomineralization is mediated by enamel proteins synthesized by ameloblast cells. Two classes of proteins have been described: enamelins and amelogenins. In lower vertebrates the absence...Full Text Available

UK PubMed Central (United Kingdom)

Plants that contain high concentrations of the defense compounds of the phenylpropene class (eugenol, chavicol, and their derivatives) have been recognized since antiquity as important spices for...Full Text Available

UK PubMed Central (United Kingdom)

In Experiment I, lever pressing by squirrel monkeys was maintained under a sequence of variable-interval, multiple variable-interval variable-interval, and multiple variable-interval extinction schedules...Full Text Available

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Withania somnifera (L.) Dunal (Family, Solanaceae), commonly known as Ashwagandha is one of the most valuable medicinal plants synthesizing large number of pharmacologically active secondary metabolites known as withanolides. Though the plant has been well characterized in terms of phytochemical profiles as well as pharmaceutical activities, not much is known about the genes responsible for biosynthesis of these compounds. In this study, we have characterized a gene encoding farnesyl diphosphate synthase (FPPS; EC 2.5.1.10), a key enzyme in the pathway of biosynthesis of isoprenoids, from W. somnifera. The full-length cDNA of Withania somnifera FPPS (WsFPPS) of 1,253?bps encodes a polypeptide of 343 amino acids. The amino acid sequence homology and phylogenetic analysis suggest that WsFPPS...

British Library Electronic Table of Contents (United Kingdom)

Cancer cells recruit monocytes, macrophages and other inflammatory cells by producing abundant chemoattractants and growth factors, such as macrophage colony-stimulating factor (M-CSF/CSF-1) and monocyte chemoattractant protein-1 (MCP-1/CCL2), to promote tumor growth and dissemination. An understanding of the mechanisms that target cancer cells and regulate tumor microenvironment is essential in designing anticancer therapies. Here, we showed that serum amyloid-A (SAA) and cathelicidin (LL-37) stimulated M-CSF and MCP-1 expression with or without lipopolysaccharide (LPS) administration; conversely, lipoxin-A4 (LXA4) and annexin-A1 (ANXA1) inhibited LPS-induced M-CSF and MCP-1 production by human (HepG2) and mouse (H22) hepatocellular carcinoma cells (HCCs). The effects of LXA4, ANXA1, SAA ...

UK PubMed Central (United Kingdom)

The bifunctional wax ester synthase/acyl coenzyme A (acyl-CoA):diacylglycerol acyltransferase (WS/DGAT) from Acinetobacter sp. strain ADP1 (formerly Acinetobacter calcoaceticus...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

With the aim of an experimental check on the validity of the theory of molecular recognition, the authors have carried out the chemical-enzymatic synthesis and cloning of the gene of human calcitonin and also of the genes of antisense polypeptides to human calcitonin and miniproinsulin. It has been shown that recombinant plasmids obtained on the basis of these synthetic genes are capable of ensuring the biosynthesis of the given polypeptides in E. coli cells as hybrid proteins with the IgG-binding domain of staphylococcal protein A.

UK PubMed Central (United Kingdom)

Detached first leaves of 3-day-old corn seedlings (Zea mays L. W64AxW183E) were incubated with nitrate in air or 100% O₂ in the light. Nitrate accumulation in the leaves...Full Text Available

UK PubMed Central (United Kingdom)

In Streptococcus pneumoniae, CpsB, CpsC, and CpsD are essential for encapsulation, and mutants containing deletions of cpsB, cpsC, or cpsD...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

The special features of prostaglandin biochemistry, of importance for investigation of the possible physiological roles of prostaglandins, are briefly reviewed. The formation of prostaglandins and related compounds from endogenous and exogenous arachidonic acid in homogenates of human gastric mucosal and muscle-serosal layers is described. These preliminary data seem to indicate that a low conversion of exogenous precursor does not necessarily mean that the capacity of the tissue to synthesize prostaglandins from endogenous precursor is low.

Science.gov (United States)

The insulin signaling pathway, involving protein kinase B (PKB) and mitogen-activated protein kinase (MAPK), mediates the biological response to insulin and several growth factors and cytokines. To investigate the correlation between glucose transporter (Glut) biosynthesis and the insulin signaling pathway activated by novel compounds of Liriope platyphylla (LP9M80-H), alterations in Glut and key protein expression in the insulin signaling pathway were analyzed in the liver and brain of ICR mice treated with LP9M80-H. An in vitro assay showed that the highest level of insulin concentration was observed in the LP9M80-H-treated group, followed by the LP-H, LP-M, LP-E, and LP9M80-C-treated groups. Therefore, LP9M80-H was selected for use in studying the detailed mechanism of the insulin signaling pathway in animal systems. In an in vivo experiment, LP9M80-H induced a significant increase in glucose levels and a decrease of insulin concentration in the blood of mice, ...

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The state of chromatin during the cell cycle was examined using synchronized cultures of CHO hamster cells. Results support Mazia's dynamic chromosome cycle model and indicate that DNA-interactive chemotherapeutic agents elicit different types of kinetic responses in treated cells, suggesting a degree of specificity of interaction between various alkylating and intercalating agents and the genome. Effects of sarkosyl crystals, heparin, and chemotherapeutic agents, neocarzinostatin and adriamycin, on chromation are discussed. (HLW)

UK PubMed Central (United Kingdom)

Ethylene (C₂H₄) is a unique plant-signaling molecule that regulates numerous developmental processes. The key enzyme in the two-step biosynthetic pathway of ethylene is 1-aminocyclopropane-1-carboxylate...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

Examination of a chloroform extract of Dracaena loureiri Gagnep (Agavaceae), a Thia medicinal plant possessing antibacterial activity, has led to the isolation of fifteen flavenoids. The biogenic relationships among these flavenoids isolated were briefly discussed. Definition of the skeleton and the unambiguous assignment of all of the protons of the isolates was achieved through extensive 2D-homonuclear chemical shift correlation, nuclear Overhauser effect (NOE) difference spectroscopy and 2D-NOE experiments. The {sup 1}H and {sup 13}C NMR spectra of staurosporine, a potent biologically active agent from Streptomyces staurosporeus, were unambiguously assigned by using 2D homonuclear chemical shift correlation, NOE, {sup 1}H-detected heteronuclear multiple-quantum coherence via direct coupling and via multiple-bond coupling for resonance assignments of protonated and nonprotonated carbons, respectively. S. Staurosporeus was found to utilize endogenous and exogenous D- and L-isomers of ...

International Nuclear Information System (INIS)

Penicillic acid-negative mutants were obtained from a color mutant derived from Penicillium cyclopium NRRL 1888 through N-methyl-N'-nitro-N-nitrosoguanidine treatment. One mutant (SK2N6) accumulated 6-methyl-1,2,4-benzenetriol, which was not previously known to be a metabolite of P. cyclopium, in addition to orsellinic acid and orcinol. The radioactivity of [1-"1"4C]acetic acid was rapidly incorporated into 6-methyl-1,2,4-benzenetriol in a culture of P. cyclopium SK2N6. Moreover, the radioactivity of ["1"4C]6-methyl-1,2,4-benzenetriol was efficiently incorporated into penicillic acid in a culture of P. cyclopium NRRL 1888. These data indicate that 6-methyl-1,2,4-benzenetriol is a precursor for penicillic acid biosynthesis. The results on the addition of 1,4-dihydroxy-6-methoxy-2-methylbenzene, 6-methoxy-2-methylbenzoquinone (1,4), and 1-O-methylorcinol to a culture of P. cyclopium SK2N6 indicated that only the former two compounds are converted to penicillic acid. ...

DEFF Research Database (Denmark)

Udgivelsesdato: May 2009

KoreaScience (Korea)

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Attention is given to the folowing topics: population I and II variable stars; LP variables, the sun, and mass determination; and predegenerate and degenerate variables. Particular papers are presented on alternative evolutionary approaches to the absolute magnitude of the RR Lyrae variables; the evolution of the Cepheid stars; nonradial pulsations in rapidly rotating Delta Scuti stars; dynamical models of dust shells around Mira variables; and pulsations of central stars of planetary nebulae.

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Elevated nuclear factor kappa B (NF-@kB) activity and interleukin-6 (IL-6) secretion participates in the pathology of several age and inflammatory-related diseases, including age-related macular degeneration (AMD), in which retinal pigment epithelial cells are the key target. Recent findings reveal that heat shock protein 70 (Hsp70) may affect regulation of NF-@kB. In the current study, effects of Hsp70 expression on NF-@kB RelA/p65 activity were evaluated in human retinal pigment epithelial cells (ARPE-19) by using celastrol, a novel anti-inflammatory compound. Anti-inflammatory properties of celastrol were determined by measuring expression levels of IL-6 and endogenous NF-@kB levels during lipopolysaccharide (LPS) exposure by using enzyme-linked immunosorbent assays (ELISA). Cell viabil...

UK PubMed Central (United Kingdom)

A common property of aging in all animals is that chronologically and genetically identical individuals age at different rates. To unveil mechanisms that influence aging variability, we identified markers...Full Text Available

UK PubMed Central (United Kingdom)

BackgroundDue to the increased accuracy of Copy Number Variable region (CNV) break point mapping, it is now possible to say with a reasonable degree of confidence whether a gene...Full Text Available

UK PubMed Central (United Kingdom)

Background/AimsTo explore different definitions of intra-individual variability (IIV) to summarize performance on commonly utilized cognitive tests (Mini Mental State Exam; Clock...Full Text Available

UK PubMed Central (United Kingdom)

BackgroundVariable platelet response to clopidogrel has been widely observed. Studies have shown that the mean aggregation response to clopidogrel can be changed...Full Text Available

UK PubMed Central (United Kingdom)

A common approach used to fuse simultaneously recorded EEG and fMRI is to correlate trial-by-trial variability in the EEG, or variability of components derived therefrom, with the blood oxygenation...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

Abstract not provided

International Nuclear Information System (INIS)

A theory of the asymptotic functions for the case of many variables is presented. It is shown that the class F(R"N) of these generalized functions is closed in respect to the linear algebraic and analytic operations, multiplication as well as a set of linear and polynomial changes of the variables. The existence in F(R"N) of analogues (consistent with the linear operations) of the Schwartz distributions with point support is proved. In terms of these analogues, some formulae for singular products and changes of variables of the Dirac #delta#-function and its derivatives #delta#"("i")(x), x is an element of R"N, are given. (author). 14 refs.

Energy Technology Data Exchange (ETDEWEB)

Success in improving hydropower project efficiency has opened more global markets for variable-speed generator technology. Manufacturers continue to test the markets as the technology evolves. The potential of variable-speed application becomes evident considering that more than 150 pumped storage plants, with a combined capacity exceeding 100,000 MW, are in operation globally.

CERN Document Server

In this paper, we derive the moderate deviation principle for stationary sequences of bounded random variables with values in a Hilbert space. The conditions obtained are expressed in terms of martingale-type conditions. The main tools are martingale approximations and a new Hoeffding inequality for non adpated sequences of Hilbert-valued random variables. Applications to Cramer-Von Mises statistics, functions of linear processes and stable Markov chains are given.

International Nuclear Information System (INIS)

In recent years there has been a renewed interest in the treatment of quantum mechanics in terms of joint distribution functions, i.e. functions of momentum and position coordinates p and q. The author considers j.d.f. in the sense of classical probability theory of a stochastic variable. The j.d.f. is then interpreted as the probability that the variables p and q have certain values, the variables being considered as a property possessed by the object system. This formalism is used to provide a unified description of bradyons and tachyons. (Auth.).

Science.gov (United States)

Respiration and related physiologic variables in different tissues of Barytelphusa guerini and the respiration of this freshwater crab as a whole are closely synchronized in phase and in frequency along the circadian scale, in the face of large differences in circadian amplitude. A very close timing of most of the 36 variables examined in 2 separate circadian profiles and a modulation of some of these variables in added profiles as a function of lunar stage are clearly demonstrable, statistically significant and illustrative of time relations at 2 interacting frequencies. PMID:6745009

Science.gov (United States)

Hydrogen cyanide (HCN) production by Pseudomonas aeruginosa in a synthetic medium is stimulated by the presence of glycine. Methionine enhances this stimulation but will not substitute for glycine as a stimulator of cyanogenesis. Threonine and phenylalanine are effective substitutes for glycine in the stimulation of HCN production. Glycine, threonine, and serine are good radioisotope precursors of HCN, but methionine and phenylalanine are not. Cell extracts of P. aeruginosa convert (/sup 14/C)threonine to (/sup 14/C)glycine. H14CN is produced with low dilution of label from either (1-/sup 14/C)glycine or (2-/sup 14/C)glycine, indicating a randomization of label either in the primary or secondary metabolism of glycine. When whole cells were fed (1,2-/sup 14/C)glycine, cyanide and bicarbonate were the only radioactive extracellular products observed.

British Library Electronic Table of Contents (United Kingdom)

The full length cDNA of the Brn1 was first cloned, and then expression of the Brn1 was analyzed and the function was identified by silencing technology. Results show that the full length cDNA of the C. lunata Brn1 gene contains 1001 base pairs and an 801?bp open reading frame encoding 267 amino acids. Semi-quantitative PCR analysis shows that the expression of Brn1 at 96?h is significantly higher than at 24 and 72?h (p?Brn1-silenced transformants were light brown in culture filtrate, and have significantly reduced toxin production relative to the wild-type. These results imply that Brn1 gene in C. lunata is not only involved in 1,8-dihydroxynaphthalene melanin synthesis, but is also relatively associated with toxin biosynthesis of the pathogen.

Energy Technology Data Exchange (ETDEWEB)

Culturing human prostate PC-3 cells for 4, 24, or 72 h in the presence of 5,8,11,14-eicosatetraynoic acid (ETYA), an inhibitor of arachidonic acid metabolism and cholesterol biosynthesis, markedly altered the morphology and reduced the number of mitochondria in the treated cells. Using quantitative electron microscopic morphometry, we documented changes in the number, form, area, matrix density, and integrity of the cristae and limiting membranes of mitochondria in cells cultured with ETYA. The inhibition of cholesterol synthesis or the substitution of ETYA for polyunsaturated fatty acids in the inner membrane may participate in the disruption of the mitochondria, which resembles the morphologic sequelae of oxidative stress. If sufficiently extensive, these changes could contribute to the inhibition of cellular proliferation by ETYA.

Science.gov (United States)

BackgroundBiodiesel or ethanol derived from lipids or starch produced by microalgae may overcome many of the sustainability challenges previously ascribed to petroleum-based fuels and first generation plant-based biofuels. The paucity of microalgae genome sequences, however, limits gene-based biofuel feedstock optimization studies. Here we describe the sequencing and de novo transcriptome assembly for the non-model microalgae species, Dunaliella tertiolecta, and identify pathways and genes of importance related to biofuel production.ResultsNext generation DNA pyrosequencing technology applied to D. tertiolecta transcripts produced 1,363,336 high quality reads with an average length of 400 bases. Following quality and size trimming, ~ 45% of the high quality reads were assembled into 33,307 isotigs with a 31-fold coverage and 376,482 singletons. Assembled sequences and singletons were subjected to BLAST similarity searches and annotated with Gene Ontology (GO) and Kyoto Encyclopedia of ...

Energy Technology Data Exchange (ETDEWEB)

Dunaliella salina cells were pulse-labeled for 2 min with (/sup 14/C)palmitic acid, (/sup 14/C)oleic acid, or (/sup 14/C)lauric acid in order to trace the pathway of galactolipid biosynthesis and desaturation. Through the use of high performance liquid chromatography it was possible to follow the movement of radioactivity through many individual molecular species of monogalactosyldiacylglycerol (MGDG) and digalactosyldiacylglycerol (DGDG) for periods of 24 h and, in some cases, as much as 120 h. Analysis of the fatty acid fluxes permitted us to refine current views regarding biosynthesis of the predominantly prokaryotic galactolipids. The initial D. salina MGDG molecular species, containing paired oleate and palmitate (18:1/16:0), can follow two metabolic routes. If the palmitoyl chain is desaturated to 16:1, the resulting 18:1/16:1 MGDG is subject to rapid further desaturation to varying degrees, and a part of these products is subsequently ...

Energy Technology Data Exchange (ETDEWEB)

The effect of insulin on protein biosynthesis was examined in differentiated 3T3-L1 and 3T3-F442A adipocytes. Insulin altered the relative rate of synthesis of specific proteins independent of its ability to hasten conversion of the fibroblast (preadipocyte) phenotype to the adipocyte phenotype. Although more than one pattern of response to insulin was observed, the authors focused on the induction of a Mr 33,000 protein which was identified as the glycolytic enzyme glyceraldehyde-3-phosphate dehydrogenase (GAPDH). Exposure of 3T3 adipocytes to insulin throughout differentiation specifically increased GAPDH activity and protein content by 2- to 3-fold as compared to 3T3 adipocytes differentiated in the absence of insulin. These changes in enzyme activity and content could be accounted for by a 4-fold increase in the relative rate of synthesis of GAPDH and a 9-fold increase in hybridizable mRNA levels. Within 2 h of insulin addition to 3T3 adipocytes differentiated ...

DEFF Research Database (Denmark)

Antisense- or RNAi-mediated suppression of the biosynthesis of nutritionally inferior storage proteins is a promising strategy for improving the amino acid profile of seeds. However, the potential pleiotropic effects of this on interconnected pathways and the agronomic quality traits need to be addressed. In the current study, a transcriptomic analysis of an antisense C-hordein line of barley was performed, using a grain-specific cDNA array. The C-hordein antisense line is characterized by marked changes in storage protein and amino acid profiles, while the seed weight is within the normal range and no external morphological irregularities were observed. The results of the transcriptome analysis showed excellent correlation with data on changes in the relative proportions of storage proteins and amino acid composition. The antisense line had a lower C-hordein level and down-regulated transcript encoding C-hordein. The production of the S-rich B/gamma- and ...

Scientific Electronic Library Online (English)

Abstract in english BACKGROUND: Severe pathogenic infection triggers excessive release of cytokines as part of the massive inflammatory response associated with septic shock. OBJECTIVES: To investigate the protective effect of caffeic acid phenethye ester (CAPE) against lipopolysaccharide (LPS) induced endotoxemia, hepatic and neuronal damage and the associated systemic inflammatory response (SIR). METHODS: Fifty male Wister rats were divided into: control, LPS, and CAPE+LPS groups. Plasma c (more) oncentrations of various cytokines, including TNF-?, IL-1?, IL-1?, IL-6, IL-4, IL-10, and sICAM-1 were evaluated. In addition, the histopathological changes in the hepatic and neural cells were assessed. RESULTS: The LPS group showed high inflammatory cytokines and sICAM-1 levels reflecting the presence of SIR. Hepatocyte necrosis, apoptosis, extensive hemorrhage and inflammatory cellular infiltration together with brain astrocytes swelling, early neuron injury and ...

Energy Technology Data Exchange (ETDEWEB)

A cDNA library was constructed using RNA isolated from the livers of chickens which had been treated with zinc. This library was screened with a RNA probe complementary to mouse metallothionein-I (MT), and eight chicken MT cDNA clones were obtained. All of the cDNA clones contained nucleotide sequences homologous to regions of the longest (375 bp) cDNA clone. The latter contained an open reading frame of 189 bp, and the deduced amino acid sequence indicates a protein of 63 amino acids of which 20 are cysteine residues. Amino acid composition and partial amino acid sequence analyses of purified chicken MT protein agreed with the amino acid composition and sequence deduced from the cloned cDNA. Amino acid sequence comparison establish that chicken MT shares extensive homology with mammalian MTs. Southern blot analysis of chicken DNA indicates that the chicken MT gene is not a part of a large family of related sequences, but rather is likely to be a unique gene sequence. In the chicken ...

British Library Electronic Table of Contents (United Kingdom)

This research investigates the impact of national culture and several institutional factors on the safety performance of society and establishes statistically significant relationships between those variables. As expected, the research results reveal that some cultural variables such as uncertainty avoidance, gender orientation and institutional variables such as the degree of law avoidance can directly influence the safety performance of the society. The findings also support the inverted u-curve (Safety Kuznet curve) hypothesis indicating even if we expect a negative trend at the beginning stage of industrialization, we can expect a positive trend in safety performance as their income level continues to improve beyond a certain point.

Energy Technology Data Exchange (ETDEWEB)

Creep properties of modified 9 Cr-1 Mo steel, an alloy significantly improved in elevated-temperature strength over 2 1/4 Cr-1 Mo and other similar alloys, are presented here. Data are primarily on material in the normalized and tempered condition. Effects of variables such as isothermal annealing treatment, cold work, normalizing temperature, tempering temperature, notch, and biaxial stress state have also been examined. Data analysis and comparisons have shown that modified 9 Cr-1 Mo alloy is very insensitive in response to several material variables, heat treatments, and specimen design variables.

UK PubMed Central (United Kingdom)

The proteolytic activities of a disintegrin and metalloproteinase (ADAM); a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS), and matrix metalloproteinase (MMP) families play important...Full Text Available

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the southern Arabian Gulf region left its signature on the heterogeneous aerosol .... Arabian Gulf region, since large differences in ? may be caused by ...

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... Variable, Alimentos mal enlatados, especialmente verduras enlatadas en el hogar; pescado fermentado, papas asadas en papel de aluminio, ajo envasado. ...

British Library Electronic Table of Contents (United Kingdom)

A central composite design was employed to optimize the extraction of pectin with citric acid. The independent variables were citric acid concentration (0.086-2.91% w/v) and extraction time (17-102min). The combined effect of these variables on the degree of esterification was investigated. Results have shown that the generated regression models adequately explained the data variation and significantly represented the actual relationship between the independent variables and the responses. Besides that, the citric acid concentration was the most important factor to affect the degree of esterification, as it exerted a significant influence on the dependent variable. Lower citric acid concentration increased the pectin degree of esterification. The surface response showed the relationships b...

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Worldwide century-long forest hydrologic research has documented that deforestation and forestation (i.e. reforestation and afforestation) can have variable ...

UK PubMed Central (United Kingdom)

According to classical concepts of physiologic control, healthy systems are self-regulated to reduce variability and maintain physiologic constancy. Contrary to the predictions of homeostasis, however,...Full Text Available

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Statistically based experimental designs were applied to screen and optimize the bioleaching of spent hydrocracking catalyst by Penicillium simplicissimum. Eleven factors were examined for their significance on bioleaching using a Plackett-Burman factorial design. Four significant variables (pulp density, sucrose, NaNO"3, and yeast extract concentrations) were selected for the optimization studies. The combined effect of these variables on metal bioleaching was studied using a central composite design (CCD). Second-order polynomials were established to identify the relationship between the recovery percent of the metals and the four significant variables. The optimal values of the variables for maximum metals bioleaching were as follows: pulp density (4.0%, w/v), sucrose (90g/L), NaNO"3 (2...

Science.gov (United States)

Wildlife Refuge, CA Rare and endangered endemic plants Diana Anderson Northern Arizona University Geomorphology Kathryn Thomas USGS, Flagstaff, AZ Vegetation dynamics John...

Science.gov (United States)

pedel preo,ure. (_PD). VSO may be developed by nor_:el epeed-o-_eter means at the output. ,haft or it may be derived ...

British Library Electronic Table of Contents (United Kingdom)

The study has analysed the effects of various factors on hydroelectric power generation potential to include climate change/variability, water demand, and installation of proposed hydroelectric power schemes in the Zambezi River Basin. An assessment of historical (1970?2000) power potential in relation to climate change/variability at existing hydro electric power schemes(Cahora Bassa, Kariba, Kafue Gorge and Itezhi-Tezhi) in the Zambezi River Basin was conducted. The correlation of hydroelectric power potential with climate change/variability aimed at observing the link and extent of influence of the latter on the former was investigated. In order to predict the future outlook of hydro electric power potential, General Circulation Models (GCM) were used to generate projected precipitation...

CERN Document Server

We construct the Baxter Q-operator and the representation of the Separated Variables (SoV) for the homogeneous open SL(2,R) spin chain. Applying the diagrammatical approach, we calculate Sklyanin's integration measure in the separated variables and obtain the solution to the spectral problem for the model in terms of the eigenvalues of the Q-operator. We show that the transition kernel to the SoV representation is factorized into the product of certain operators each depending on a single separated variable. As a consequence, it has a universal pyramid-like form that has been already observed for various quantum integrable models such as periodic Toda chain, closed SL(2,R) and SL(2,C) spin chains.

CERN Document Server

We obtain an elegant and useful description of the dynamics of Szekeres dust models (in their full generality) by means of "quasi--local" scalar variables constructed by suitable integral distributions that can be interpreted as weighed proper volume averages of the local covariant scalars. In terms of these variables, the field equations and basic physical and geometric quantities are formally identical to their corresponding expressions in the spherically symmetric LTB dust models. Since we can map every Szekeres model to a unique LTB model, rigorous results valid for the latter models can be readily generalized to a non--spherical Szekeres geometry. The new variables lead naturally to an initial value formulation in which all scalars are expressed as scaling laws in terms of their values at an arbitrary initial space slice. These variables also yield a significant simplification of numerical work, ...

Energy Technology Data Exchange (ETDEWEB)

Following tuber excision from the mother plant sucrose synthase activity fell from 3,120 to 960 nmol/g.f. wt./h within 7 days and starch synthesis ({sup 14}C sucrose incorporated into isolated discs) from 23 to 7 nmol/g.f. wt./h. While the maximum catalytic activity of sucrose synthase was more than sufficient to account for the observed rate of starch synthesis a maximum of 27% of sucrose incorporated by discs was converted into starch within 3 h. This compared with 80% conversion of {sup 14}C glucose incorporated. Tuber excision also reduced the rate of starch biosynthesis with glucose as a substrate (from 206 to 64 nmol/g.f. wt./h). The activities of UDPG-pyrophosphorylase, PPi-PFK, ATP-PFK, starch synthase and hexokinase (glucose or fructose substrates) were unaffected by tuber removal. ADPG pyrophosphorylase activity was reduced from 8,000 to 4,500 nmol/g.f. wt./h. Preliminary experiments indicate that the decline in sucrose synthease activity is prevented by ...

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Arachidonic acid is metabolized by means of P450 isoenzyme(s) to form epoxyeicosatrienoic acids (EETs) and their corresponding dihydroxy derivatives (DHETs). In the present study, we established the presence in human urine of 8,9-, 11,12-, and 14,15-EETs and their corresponding DHETs by developing quantitative assays and using negative ion, chemical ionization GC/MS and octadeuterated internal standards. Urinary excretion of 8,9- and 11,12-DHET increased in healthy pregnant women compared with nonpregnant female volunteers. By contrast, excretion of 11,12-DHET and 14,15-DHET, but not the 8,9-DHET regioisomer, increased even further in patients with pregnancy-induced hypertension. Intravenous administration of (3H)14,15-EET to three dogs markedly increased its DHET in plasma. The terminal half-life ranged from 7.9-12.3 min and the volume of distribution (3.5-5.3 liters) suggested limited distribution outside the plasma compartment. Negligible radioactivity was detected in urine; this ...

International Nuclear Information System (INIS)

The work scope of 'Biological Research for the Radiation Protection' had contained the research about ornithine decarboxylase and its controlling proteins, thioredoxin, peroxiredoxin, S-adenosymethionine decarboxylase, and glutamate decarboxylase 67KD effect on the cell death triggered ionizing radiation and H_2O_2(toxic agents). In this study, to elucidate the role of these proteins in the ionizing radiation (or H_2O_2)-induced apoptotic cell death, we utilized sensesed (or antisensed) cells, which overexpress (or down-regulate) RNAs associated with these proteins biosynthesis, and investigated the effects of these genes on the cytotoxicity caused by ionizing radiation and H_2O_2(or paraquat). We also investigated whether genisteine(or thiamine) may enhance the cytotoxic efficacy of tumor cells caused by ionizing radiation (may enhance the preventing effect radiation or paraquat-induced damage) because such compounds are able to potentiate the cell-killing or cell ...

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Synthesis of silver nanoparticles based on a polyol process and variable frequency microwave (VFM) was investigated. Comparing to a thermal method, the reaction by VFM radiation was much faster. The effects of silver nitrate concentration, poly(N-vinylpyrrolidone) (PVP) concentration, reaction time and reaction temperature were studied. It was found that the higher concentration of silver nitrate, longer reaction time and higher temperature increased the particle size while the higher concentration of PVP decreased the particle size.

International Nuclear Information System (INIS)

In the case of large capacity steam turbines the conventional nozzle group control is, for mechanical and thermodynamic reasons, diminishing more and more in importance in favour of variable pressure control. A design for constant-pressure operation as an alternative to nozzle group control is described; this demonstrates a series of important advantages compared with the latter. (orig.).

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This book contains the Proceedings of the Conference on Climate and Water under the following groupings: Impacts of climatic variability and change-resulting from the changes in hydrological variables; Aquatic environment; Terrestrial environment; Coastal zones and navigation; Urban and industrial water supply and drainage; Energy production; Intropogenic changes of climate and water management problems; Flood potential; Irrigation and land drainage.

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The effect of fetal distress on the neonatal brain was investigated by neonatal CT brain scan, FHR monitoring and mode of delivery. This study involved 11 cases of full term vertex delivery in which FHR was recorded by fetal direct ECG during the second stage labor. All infants weighed 2,500 g or more. FHR monitoring was evaluated by Hon's classification. Neonatal brain edema was evaluated by cranial CT histgraphic analysis (Nakada's method). 1) Subdural hemorrhage was noted in 6 of 7 infants delivered by vacuum extraction or fundal pressure (Kristeller's method). 2) Intracranial hemorrhage was demonstrated in all of 3 infants with 5-min. Apgar score 7 or less. 3) Two cases with prolonged bradycardia and no variability had intraventricular or intracerebral hemorrhage which resulted in severe central nervous system damage. 4) The degree of neonatal brain edema correlated with 5-min. Apgar score. 5) One case with prolonged bradycardia and ...

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Lateral and vertical variabilities in the bulk and mechanical properties of silicic volcanic tuff at the potential nuclear waste repository site in Yucca Mountain, NV have been evaluated. Laboratory measurements have been performed on tuff specimens recovered from boreholes located to support the design of the Exploratory Studies Facility/North Ramp. The data include dry and saturated bulk densities, average grain density, porosity, compressional and shear wave velocities, elastic moduli, and compressional and tensional fracture strengths. Data from eight boreholes aligned in a northwest-southeast direction have been collected under the required quality assurance program. Three boreholes have penetrated the potential repository horizon. The information collected provides for an accurate appraisal of the variability of rock properties in the vicinity of the boreholes. As expected, there is substantial variability in the bulk ...

British Library Electronic Table of Contents (United Kingdom)

In this article, we studied the effects of variable viscosity and thermal conductivity on an unsteady two-dimensional laminar flow of a viscous incompressible conducting fluid past a semi-infinite vertical porous moving plate taking into account the effect of a magnetic field in the presence of variable suction. The fluid viscosity is assumed to vary as an inverse linear function of temperature but the thermal conductivity is assumed to vary as a linear function of temperature. It is assumed that the porous plate moves with a constant velocity in the direction of fluid flow, and the free stream velocity follows the exponentially increasing small perturbation law. The governing equations for the flow are transformed into a system of nonlinear ordinary differential equations by perturbation ...

Energy Technology Data Exchange (ETDEWEB)

An automotive powertrain includes a conventional piston engine, a continuously variable ratio transmission, an engine speed sensor and a feedback control system. The control system adjusts both the transmission ratio and the throttle valve in the engine carburetor or fuel metering system in response to the position of the accelerator pedal and in response to the crankshaft speed as measured by the engine sensor. The transmission provides extreme overdrive gear ratios which allow the engine to be operated at wide open throttle even during moderate cruising, and, in addition, the engine carburetor or fuel metering system is calibrated to deliver to the engine a stoichiometric air-fuel mixture which is combined, before combustion, with a special proportion of recirculated exhaust gas. As a result of extensive wide open throttle engine operation with the above mentioned intake charge composition, combustion variables are optimized to produce ...

British Library Electronic Table of Contents (United Kingdom)

This paper analyses Italian interregional migration flows. The approach taken is to decompose labour mobility flows into short distance and long distance migration and to model the effects of economic variables, social capital and quality of life variables, and amenity variables, on the mobility behaviour of individuals. We estimate these different types of migration flows using a negative binomial model, augmented with instruments to control for potential endogeneity issues. Our findings demonstrate that long distance migration reflects a disequilibrium model of migration whereas short distance migration largely reflects an equilibrium model of migration. As such, attempts to model interregional migration in general will be mis-specified as the simultaneously-operating underlying mobility...

British Library Electronic Table of Contents (United Kingdom)

Various SST indices in the Indo-Pacific region have been proposed in the literature in light of a long-range seasonal forecasting of the Indian Summer Monsoon (ISM). However, the dynamics associated with these different indices have never been compared in detail. To this end, the present work re-examines the variabilities of ISM rainfall, onset and withdrawal dates at interannual timescales and explores their relationships with El Ni?o-Southern Oscillation (ENSO) and various modes of coupled variability in the Indian Ocean. Based on recent findings in the literature, five SST indices are considered here: Ni?o3.4 SST index in December?January both preceding [Nino(?1)] and following the ISM [Nino(0)], South East Indian Ocean (SEIO) SST in February?March, the Indian Ocean Basin (IOB) mode in ...

British Library Electronic Table of Contents (United Kingdom)

Abstract Mammalian teeth exhibit incremental structures representing successive forming fronts of enamel at varying time scales, including a short daily increment called a cross striation and a long period called a stria of Retzius, the latter of which, in humans, occurs on average every 8-9 days. The number of daily increments between striae is called the repeat interval, which is the same period as that required to form one increment of bone, i.e. the lamella, the fundamental - if not archetypal - unit of bone. Lamellae of known formation time nevertheless vary in width, and thus their measures provide time-calibrated growth rate variability. We measured growth rate variability for as many as 6 years of continuously forming primary incremental lamellar bone from midshaft femur histologic...

British Library Electronic Table of Contents (United Kingdom)

Purpose Nonpoint sources (NPS) pollution has been an important cause for water quality impairment worldwide. To take the temporal variations of both NPS pollution and in-stream attenuation into consideration, an inverse modeling approach and the load duration curve (LDC) method were combined for variable nutrient total maximum daily load (TMDL) development. Methods Water quality and hydrological parameters were monitored monthly along the ChangLe River system in 2004?2008. The catchment NPS export load (EL) and TMDL for total nitrogen (TN) were estimated by the inverse format of an existing stream nutrient transport equation. The LDC method was used to describe the variability of EL, TMDL, requiring load (RLR) and percent (the ratio between the RLR and the EL, RPR) reduction, and then to s...

British Library Electronic Table of Contents (United Kingdom)

Multi-millennial climate changes were relatively minor over the mid-late Holocene in the British Isles, because orbitally forced insolation changes were smaller than those at higher latitudes. Centennial climate variability is thus likely to have exerted a greater influence on the environment and human society of the region. Proxy-climate records from the British Isles covering the last 4500years are assembled and re-evaluated with the aim of identifying centennial climate variability reflected by multi-proxy indicators. The proxies include bog oak populations, peatland surface wetness, flooding episodes from fluvial deposits, speleothem annual band width and oxygen isotopes, chironomids from lake sediments and sand and dune deposition. Most proxies reflect water balance rather than temper...

Science.gov (United States)

This paper focuses on a factorial-based design strategy. The approach provides an efficient and statistically reliable means for assessing the influence of multivariable effects. It is applied to the detection and evaluation of damage in impacted composite sandwich panels. The experimental results obtained from this test strategy are utilized to form an empirical response function. The resulting polynomial relates damage area to residual compression strength at values of independent variables for which testing did not occur. The response function also identifies nonlinear interaction effects of key variabes that cannot be easily ascertained by traditional single-variable test strategies. Independent variables evaluated include core thickness, number of face sheet plys and impact energy. The methodology presented allows the designer to predict with more confidence the damage tolerance of a composite material component, and ...

British Library Electronic Table of Contents (United Kingdom)

Experiments based on a 23 central composite full factorial design were carried out in 200-ml stainless-steel containers to study the pretreatment, with dilute sulfuric acid, of a sugarcane bagasse sample obtained from a local sugar?alcohol mill. The independent variables selected for study were temperature, varied from 112.5?C to 157.5?C, residence time, varied from 5.0 to 35.0 min, and sulfuric acid concentration, varied from 0.0% to 3.0% (w/v). Bagasse loading of 15% (w/w) was used in all experiments. Statistical analysis of the experimental results showed that all three independent variables significantly influenced the response variables, namely the bagasse solubilization, efficiency of xylose recovery in the hemicellulosic hydrolysate, efficiency of cellulose enzymatic saccharificatio...

UK PubMed Central (United Kingdom)

Effector proteins expressed in the esophageal gland cells of cyst nematodes are delivered into plant cells through a hollow, protrusible stylet. Although evidence indicates that effector proteins function...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

Expressions for the spatial moments and macrodispersion tensor for sorbing solutes in heterogeneous formations were presented using a probabilistic model of a fluid residence time coupled with the particle position analysis. The fluid residence time was defined as a fraction of the actual time during which the particle stayed in the mobile fluid phase of the aquifer. The fluid residence time is a random variable whose variability comes as a result of the non-equilibrium sorption properties. The sorbing solute was assumed to be governed with first-order linear kinetics. The closed-form expressions were based on the stationarity in the kinetic process and on the first-order approximation in the hydraulic conductivity field and in the fluid residence time. The non-equilibrium effects were presented as a function of the spatial variability in hydraulic conductivity and temporal variability in the fluid ...

UK PubMed Central (United Kingdom)

Activation-induced deaminase (AID) initiates somatic hypermutation, gene conversion and class switch recombination by deaminating variable and switch region DNA cytidines to uridines. AID is predominantly...Full Text Available

UK PubMed Central (United Kingdom)

A previous report of high levels of members of the domain Archaea in Antarctic coastal waters prompted us to investigate the ecology of Antarctic planktonic prokaryotes. rRNA hybridization...Full Text Available

UK PubMed Central (United Kingdom)

Dependent variables in research on problem behavior typically are based on measures of response repetition, but these measures may be problematic when behavior poses high risk or when its occurrence...Full Text Available

UK PubMed Central (United Kingdom)

Information from the Health Assessment Questionnaire (HAQ) is used to identify which variables measured in 1981 successfully predict the severity of disease in 1989 and the eight year change in severity...Full Text Available

UK PubMed Central (United Kingdom)

BackgroundAn earlier study showed that a week of yoga practice was useful in stress management after a natural calamity. Due to heavy rain and a rift on the banks of the Kosi river,...Full Text Available

CERN Document Server

Using the POLISH instrument, I am unable to reproduce the large-amplitude polarimetric observations of Berdyugina et al. (2008) to the >99.99% confidence level. I observe no significant polarimetric variability in the HD 189733 system, and the upper limit to variability from the exoplanet is Delta_P < 7.9 x 10^(-5) with 99% confidence in the 400 nm to 675 nm wavelength range. Berdyugina et al. (2008) report polarized, scattered light from the atmosphere of the HD 189733b hot Jupiter with an amplitude of two parts in 10^4. Such a large amplitude is over an order of magnitude larger than expected given a geometric albedo similar to other hot Jupiters. However, my non-detection of polarimetric variability phase-locked to the orbital period of the exoplanet, and the lack of any significant variability, shows that the polarimetric modulation reported by Berdyugina et al. (2008) cannot be due to the ...

UK PubMed Central (United Kingdom)

The sequence-dependent structural variability and conformational dynamics of DNA play pivotal roles in many biological milieus, such as in the site-specific binding of transcription factors to target...Full Text Available

UK PubMed Central (United Kingdom)

Despite the demonstrated clinical efficacy of CD20 monoclonal antibody (mAb) for lymphoma therapy, the in vivo mechanisms of tumor depletion remain controversial and variable. To identify the molecular...Full Text Available

UK PubMed Central (United Kingdom)

Simulations with a regional chemical transport model show that anthropogenic emissions of volatile organic compounds and nitrogen oxides (NO_x = NO + NO₂) lead to a dramatic diurnal...Full Text Available

UK PubMed Central (United Kingdom)

Random forest (RF) analysis of genetic data does not require specification of the mode of inheritance, and provides measures of variable importance that incorporate interaction effects. In this paper...Full Text Available

UK PubMed Central (United Kingdom)

In this review we attempt to reconstruct the evolutionary history of hominin life history from extant and fossil evidence. We utilize demographic life history theory and distinguish life history variables,...Full Text Available

Science.gov (United States)

High speed experimental tests provided data on six parametric cylindrical roller bearings. Four bearing variables were evaluated and the results were correlated with the analytical model developed under Naval Air Propulsion Center Contract N00140-76-C-038...

International Nuclear Information System (INIS)

The systems for which the algebra of gauge transformations in the lagrangian formalism is closed, are considered. The hamiltonian BRST charge and the BRST-invariant hamiltonian are found explicitly. Their expansions in powers of the ghost variables contain, in general, an infinite number of terms. (orig.).

UK PubMed Central (United Kingdom)

The torque-velocity relationship is known to be affected by ageing, decreasing its protective role in the prevention of falls. Interindividual variability in this torque-velocity relationship is partly...Full Text Available

UK PubMed Central (United Kingdom)

Exercise is essential for health, yet the amount, duration, and intensity that individuals engage in are strikingly variable, even under prescription. Our focus was to identify the locations and effects...Full Text Available

Science.gov (United States)

The aim of the present study focuses on experimentally demonstrating the efficacy of using angularly-variable fiber geometry to achieve the desired tissue-layer selection and probing depths with the further objective of enhancing the sensitivity and specificity of spectral diagnosis in stratified architectures that resemble human cervical epithelia. The morphological and biochemical features of epithelial tissue vary in accordance with tissue depths; consequently, the accuracy of spectroscopic diagnosis of epithelial dysplasia may be enhanced by probing the optical properties of this tissue. When correlated to cellular dysplasia, layer-specific changes in tissue optical properties may be deciphered by reflectance spectroscopy coupled with angularly-variable fiber geometry. This study addresses the utility of using such angularly-variable fiber geometry for resolving spatially-specific spectral signatures of tissue ...

Science.gov (United States)

... 1984; Martin-Mora et al., 1995), and parasitism (Rothschild and Rothschild, 1939; Pesigan et al., 1958; Moose, 1963; Pan, ... effects of digeneans are variable; they may enhance (Rothschild and Rothschild...

International Nuclear Information System (INIS)

Energy confinement in W7-AS has been analyzed in terms of dimensionally exact form free functions employing Bayesian probability theory. The confinement function was set up as a linear combination of dimensionally exact power law terms as already proposed very early by Connor and Taylor. Generation of this expansion basis is dictated by the basic plasma model which one assumes. Based upon data accumulated in W7-AS, which contains the energy content for a wide variety of variable settings, predictions for single variable scans are made. The scaling functions for density and power scans, respectively, are in quantitative agreement with data collected in W7-AS. The result of a single variable scan is therefore already hidden in the data obtained for arbitrary variable choices and can be extracted from the latter by a proper data analysis. Furthermore, the optimal model for the description of the global ...

UK PubMed Central (United Kingdom)

Certain structural and environmental factors other than technical combination of resources and firm size are hypothesized to affect medical practice output. Four groups of variables related to physician...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

In recent years the modelling of interannual climate variability has been studied, the atmospheric energy and water cycles, and climate simulations with the ECHAM3 model. In addition, the climate simulations of several models have been compared with special emphasis in the area of northern Europe

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In this report, the main emphasis is given to (1) the problems associated with the basic calibration of the spectroradiometer and (2) the year-to-year variability of the calibrations of the solar UV network radiometers. Also, the results from intercomparisons of the Brewer and OL 742 spectroradiometers are included

British Library Electronic Table of Contents (United Kingdom)

An elliptic equation in a rectangle with coefficients depending on a fast variable and with its period being a small parameter is considered. An asymptotic expansion of the solution up to an arbitrary degree of the small parameter is constructed and substantiated by applying the two-scale expansion method.

UK PubMed Central (United Kingdom)

Visual assessment of the degree of renal artery stenosis on renal arteriography has a large inter- and intraobserver variability. This degree is usually estimated by the ratio between the most narrowed...Full Text Available

UK PubMed Central (United Kingdom)

Antiplatelet resistance has been proposed as a possible mechanism to explain recurrent cardiovascular events in patients who have coronary artery disease and who are undergoing dual antiplatelet therapy....Full Text Available

UK PubMed Central (United Kingdom)

BackgroundTraditionally in pediatric HIV, the CD4+ T-lymphocyte percent is used in monitoring disease progression due to the variability in absolute CD4+ T-lymphocyte...Full Text Available

UK PubMed Central (United Kingdom)

PurposeTo detail the highly variable ocular phenotypes of a French family affected with an autosomal dominantly inherited vitreoretinopathy and to identify the disease gene.MethodsSixteen...Full Text Available

UK PubMed Central (United Kingdom)

Structural variants which cause changes in copy numbers constitute an important component of genomic variability. They account for 0.7% of genomic differences in two individual genomes, of which...Full Text Available

Science.gov (United States)

This report describes the design, fabrication, installation and testing of a small variable-speed vertical axis wind turbine (VAWT). This VAWT is unique in its installation using hand tools only; unconventional and simple support system; and variable speed operation under microprocessor control. Initial testing confirmed that the turbine can be controlled by commanded alternator field modulation. Further studies will be directed toward determination of an optimum control algorithm.

CERN Document Server

We construct representation of the Separated Variables (SoV) for the quantum SL(2,R) Heisenberg closed spin chain and obtain the integral representation for the eigenfunctions of the model. We calculate explicitly the Sklyanin measure defining the scalar product in the SoV representation and demonstrate that the language of Feynman diagrams is extremely useful in establishing various properties of the model. The kernel of the unitary transformation to the SoV representation is described by the same "pyramid diagram" as appeared before in the SoV representation for the SL(2,C) spin magnet. We argue that this kernel is given by the product of the Baxter Q-operators projected onto a special reference state.

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The idle speed of an internal combustion engine is controlled in response to a variable ignition timing control signal from a microcomputer. The microcomputer derives this control signal as a function of the magnitude of engine speed variation which occurs during engine idle periods to cause the ignition timing to vary quickly in response to a transitory engine load variation. An auxiliary air delivery system may be advantageously incorporated in the idle speed control system to cooperate with the ignition timing control in response to the engine speed variation.

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We discuss the inclusive production of D{sup *{+-}} mesons in {gamma}p collisions at DESY HERA, based on a calculation at next-to-leading order in the general-mass variable-flavor-number scheme. In this approach, MS subtraction is applied in such a way that large logarithmic corrections are resummed in universal parton distribution and fragmentation functions and finite mass terms are taken into account. We present detailed numerical results for a comparison with data obtained at HERA and discuss various sources of theoretical uncertainties. (orig.)

Energy Technology Data Exchange (ETDEWEB)

Energy productivity and energy intensity within the industrial sector of the economy are examined. Results suggest that relative prices and other economic factors can explain much of the variation in both energy productivity and energy intensity for manufacturing and mining and for the industrial sector as a whole. Cyclical factors, seasonal factors and trend variables are also useful in explaining variation in these data, both for annual and monthly time series. Of the variables examined, it appears that the relative price of energy is a highly significant factor in accounting for the difference between actual industrial energy intensity and that which might have been expected had pre-1973 trends continued.

International Nuclear Information System (INIS)

We present a protocol for quantum key distribution using discrete modulation of coherent states of light. Information is encoded in the variable phase of coherent states which can be chosen from a regular discrete set ranging from binary to continuous modulation similar to phase-shift keying in classical communication. Information is decoded by simultaneous homodyne measurement of both quadratures and requires no active choice of basis. The protocol utilizes either direct or reverse reconciliation both with and without postselection. We analyze the security of the protocol and show how to enhance it by the optimal choice of all variable parameters of the quantum signal.

CERN Document Server

A fermionic - based on Grassmann--Berezin calculus of anticommuting variables - topological quantum field theory (TQFT) is considered, mainly in three dimensions. It is defined for piecewise-linear manifolds and, for a given triangulation, deals only with a finite number of variables. Despite its simple nature, it can distiguish between lens spaces L(7,1) and L(7,2). And despite its origin from a kind of Reidemeister torsion, it does this without using nontrivial representations of the fundamental group. Also, symbolic calculations are presented giving strong evidence of existence of similar theory in four dimensions.

Energy Technology Data Exchange (ETDEWEB)

A reliability approach for probabilistic modeling of one-dimensional non-reactive and reactive transport in porous media provides two important quantitative results: (1) an estimate of the probability that dimensionless concentration equals or exceeds some specified level and, (2) the sensitivity of the probabilistic outcome to likely changes in each uncertain variable. The reliability approach is particularly attractive because it can incorporate various marginal probability density functions (PDF) for any of the uncertain variables. In this work uncertain variables include: groundwater flow velocity, diffusion coefficient, dispersivity, distribution coefficient, porosity and bulk density. The primary objective is to examine how the probabilistic outcome is influenced by choice of marginal PDF, correlation and magnitude of uncertainty for the variables. Because little information exists concerning the ...

International Nuclear Information System (INIS)

Methanosarcina thermophila, a nonmarine methanogenic archaebacterium, can grow in a range of saline concentrations. At less than 0.4 M NaCl, Ms. thermophila accumulated glutamate in response to increasing osmotic stress. At greater than 0.4 M NaCl, this organism synthesized a modified #beta#-amino acid that was identified as N"v"a"r"-"e"p"s"i"l"o"n-acetyl-#beta#-lysine by NMR spectroscopy and ion-exchange HPLC. This #beta#-amino acid derivative accumulated to high intracellular concentrations (up to 0.6 M) in Ms. thermophila and in another methanogen examined - Methanogenium cariaci, a marine species. The compound has features that are characteristic of a compatible solute: it is neutrally charged at physiological pH and it is highly soluble. When the cells were grown in the presence of exogenous glycine betaine, a physiological pH and it is highly soluble. When the cells were grown in the presence of exogenous glycine betaine, a physiological compatible solute, ...

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Human senescence marker protein 30 (SMP30), which functions enzymatically as a lactonase, hydrolyzes various carbohydrate lactones. The penultimate step in vitamin-C biosynthesis is catalyzed by this enzyme in nonprimate mammals. It has also been implicated as an organophosphate hydrolase, with the ability to hydrolyze diisopropyl phosphofluoridate and other nerve agents. SMP30 was originally identified as an aging marker protein, whose expression decreased androgen independently in aging cells. SMP30 is also referred to as regucalcin and has been suggested to have functions in calcium homeostasis. The crystal structure of the human enzyme has been solved from X-ray diffraction data collected to a resolution of 1.4 {angstrom}. The protein has a 6-bladed {beta}-propeller fold, and it contains a single metal ion. Crystal structures have been solved with the metal site bound with either a Ca{sup 2+} or a Zn{sup 2+} atom. The catalytic role of the metal ion has been ...

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In May 1985, a National Pollutant Discharge Elimination System permit was issued for the Oak Ridge Y-12 Plant, a nuclear weapons components production facility located in Oak Ridge, Tennessee, and operated by Martin Marietta Energy Systems, Inc., for the US Department of Energy. As a condition of the permit, a Biological Monitoring and Abatement Program (BMAP) was developed to demonstrate that the effluent limitations established for the Oak Ridge Y-12 Plant protect the classified uses of the receiving stream (East Fork Poplar Creek), in particular, the growth and propagation of fish and aquatic life, as designated by the Tennessee Department of Health and Environment. A second purpose for the BMAP is to document the ecological effects resulting from implementation of a water pollution control program that will include construction of nine new wastewater treatment facilities over the next 4 years. Because of the complex nature of the effluent discharged to East Fork Poplar Creek and ...

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Identifying stable isotope variation and mineralogical changes in fractured rock may help establish the history of climatic and geomorphological processes that might affect the isolation properties of a waste repository site. This study examines the use of the stable isotope ratios of oxygen ({sup 18}O/{sup 16}O) and carbon ({sup 13}C/{sup 12}C) in authigenic minerals as hydrogeochemical tools tracing low-temperature rock-water interaction in variably-saturated fractured stuff. Isotopic compositions of fracture-filling and rock matrix minerals in the Apache Leap tuff, near Superior, Arizona were concordant with geothermal temperatures and in equilibrium with water isotopically similar to present-day meteoric water and groundwater. Oxygen and carbon isotope ratios of fracture-filling, in unsaturated fractured tuff, displayed an isotopic gradient believed to result from near-surface isotopic enrichment due to evaporation rather than the effects of rock-water ...

CERN Document Server

Starting from the original collective Hamiltonian of Bohr and separating the beta and gamma variables as in the X(5) model of Iachello, an exactly soluble model corresponding to a harmonic oscillator potential in the beta-variable (to be called X(5)-$\\beta^2$) is constructed. Furthermore, it is proved that the potentials of the form $\\beta^{2n}$ (with n being integer) provide a ``bridge'' between this new X(5)-$\\beta^2$ model (occuring for n=1) and the X(5) model (corresponding to an infinite well potential in the beta-variable, materialized for n going to infinity. Parameter-free (up to overall scale factors) predictions for spectra and B(E2) transition rates are given for the potentials $\\beta^2$, $\\beta^4$, $\\beta^6$, $\\beta^8$, corresponding to E(4)/E(2) ratios of 2.646, 2.769, 2.824, and 2.852 respectively, compared to the E(4)/E(2) ratios of 2.000 for U(5) and 2.904 for X(5). Hints about nuclei showing this ...

Science.gov (United States)

The purpose of this study was to examine the relationship between histomorphometric variables of cancellous bone structure and ultimate compressive strength (UCS) in the second lumbar vertebra (L2) and to determine whether structural variables in the iliac crest are predictive of the same variables and of UCS in L2. At autopsy, 7.5 mm diameter cores were removed from the iliac crest and from L2 of 29 subjects who had died suddenly without bone disease. Cancellous bone volume (BV/TV, %) was significantly lower in L2 than in iliac crest due to lower trabecular number (Tb.N, per mm) and thickness (Tb.Th, microns). There were significant correlations between iliac crest and L2 for BV/TV, Tb.N and trabecular separation (Tb.Sp, microns), but not for Tb.Th. BV/TV was negatively correlated, and Tb.Sp was positively correlated with age at both sites. Tb.Th was not significantly correlated with age in the iliac crest, but a ...

Energy Technology Data Exchange (ETDEWEB)

This study examines the sensitivity of the travel time distribution predicted by a reference case model to (1) scale of representation of the model parameters, (2) size of the model domain, (3) correlation range of log-transmissivity, and (4) cross correlations between transmissivity and effective thickness. The basis for the reference model is the preliminary stochastic travel time model previously documented by the Basalt Waste Isolation Project. Results of this study show the following. The variability of the predicted travel times can be adequately represented when the ratio between the size of the zones used to represent the model parameters and the log-transmissivity correlation range is less than about one-fifth. The size of the model domain and the types of boundary conditions can have a strong impact on the distribution of travel times. Longer log-transmissivity correlation ranges cause larger variability in the predicted travel times. ...

Energy Technology Data Exchange (ETDEWEB)

Automated, variable volume unloaders provide the ability to smoothly load/unload reciprocating compressors to maintain ideal operations in ever-changing environments. Potential advantages provided by this load control system include: maximizing unit capacity, optimizing power economy, maintaining low exhaust emissions, and maintaining process suction and discharge pressures. Obstacles foreseen include: reliability, stability, serviceability and automation integration. Results desired include: increased productivity for the compressor and its operators, increased up time, and more stable process control. This presentation covers: system design features with descriptions of how different types of the devices were developed, initial test data, and how they can be effectively operated; three actual-case studies detailing the reasons why automated, hydraulically controlled, variable volume, head-end unloaders were chosen over other types of ...

Science.gov (United States)

It is currently unclear if the potential for West Nile virus transmission by mosquito vectors in the eastern United States is related to landscape or climate factors or both. We compared abundance of vector species between urban and suburban neighborhoods of Henrico County, VA, in relation to the following factors: temperature, precipitation, canopy cover, building footprint, and proximity to drainage infrastructure. Mosquitoes were collected throughout the 2005, 2006, and 2007 seasons and tested for West Nile virus (WNV) in pools of 10-50. Test results of mosquito pools were compared to average site abundance from 37 sites in Henrico County, VA; abundance was then examined in relation to ecological variables. Urban infrastructure was positively correlated with the abundance of Culex pipiens L./Cx. restuans, and our findings implicate combined sewer overflow systems as large contributors to Culex vector populations. No measure of urbanization examined in our study ...

Energy Technology Data Exchange (ETDEWEB)

The Environmental Kuznets Curve (EKC) hypothesis states that pollution levels increase as a country develops, but begin to decrease as rising incomes pass beyond a turning point. In EKC analyses, the relationship between environmental degradation and income is usually expressed as a quadratic function with the turning point occurring at a maximum pollution level. Other explanatory variables have been included in these models, but income regularly has had the most significant effect on indicators of environmental quality. One variable consistently omitted in these relationships is the price of energy. This paper analyzes previous models to illustrate the importance of prices in these models and then includes prices in an econometric EKC framework testing energy/income and CO{sub 2}/income relationships. These long-run price/income models find that income is no longer the most relevant indicator of environmental quality or energy demand. Indeed, ...

Energy Technology Data Exchange (ETDEWEB)

This report describes the LIFECC computer program developed for the purpose of calculating the cost of energy produced by wind systems according to the principles of life cycle costing (LCC). Following a brief explanation of the LCC concept and its advantages, input variables to the program and their importance to various program users, including manufacturers and designers, utilities, various institutions and consumers, are explained. A detailed user's guide to the program is then provided, together with a sensitivity analysis which discusses the impact of key variables on wind system cost of energy and the importance of cash flow to the wind system purchaser. Sample cases of program output and an LIFECC program listing are provided.

Science.gov (United States)

This paper presents a semi-active vibration control of a scaled two-span bridge structure. Magneto-rheological fluid dampers are utilized as the semi-active energy absorbing deices and a bridge vibration control system is developed. Closed-loop control system based on fuzzy logic is used to suppress the bridge deck motion under random excitations. The sufficient condition for the closed-loop stability of the fuzzy control system is derived from the variable structure system theory. It is demonstrated that this stable fuzzy control system can significantly reduce the relative deck displacement using about 55 percent less power compared to passive-on state, while the absolute deck acceleration is relatively unaffected.

Energy Technology Data Exchange (ETDEWEB)

Our investigation concerns the class of Josephson-like systems, sharing the same nonlinear Hamiltonian. Among the latter a Josephson junction with an external biasing circuit is considered. We diagonalize the fully nonlinear Hamiltonian (in the superconductive regime of the junction) in the Fock space of the TBHA (two-boson Heisenberg algebra) and prove that such algebra leads quite naturally to the theoretical realization of codewords and logical operators: the codewords are defined as the even and odd coherent states of the TBHA, while the logical operators are expressed in terms of operators in the same algebra. Our theoretical construction corresponds to a continuous variable quantum computation scheme; the continuous variables are identified in terms of the physical operators of the junction. The link between this scheme and the technique of fermionization of bosonic systems is also discussed.

Energy Technology Data Exchange (ETDEWEB)

Although incompressible fluid flows can be regarded as a particular case of a general problem, numerical methods and the mathematical formulation aimed to solve compressible and incompressible flows have their own peculiarities, in such a way, that it is generally not possible to attain both regimes with a single approach. In this work, we start from a typically compressible formulation, slightly modified to make use of pressure variables and, through augmenting the stabilising parameters, we end up with a simplified model which is able to deal with a wide range of flow regimes, from supersonic to low speed gas flows. The resulting methodology is flexible enough to allow for the simulation of liquid flows as well. Examples using conservative and pressure variables are shown and the results are compared to those published in the literature, in order to validate the method. (author)

British Library Electronic Table of Contents (United Kingdom)

Viddi, F. A., Hucke-Gaete, R., Torres-Florez, J. P., and Ribeiro, S. 2010. Spatial and seasonal variability in cetacean distribution in the fjords of northern Patagonia, Chile. - ICES Journal of Marine Science, 67: 959-970. Compared with other Chilean coastal areas, little is known about the diversity and distribution of cetaceans in northern Patagonian fjords. Between December 2000 and November 2001, surveys on platforms of opportunity were undertaken in southern Chile to evaluate species richness and the spatial and seasonal distribution of cetaceans. Nine species were recorded, blue, humpback, and minke whales, Peales dolphin, Chilean dolphin, killer whale, false killer whale, bottlenose dolphin, and Cuviers beaked whale. The pattern of cetacean distribution displayed significant season...

British Library Electronic Table of Contents (United Kingdom)

Possible factors regulating phytoplankton variability in the Arabian (Persian) Gulf were analyzed on the basis of satellite observations and meteorological data (1997-2009), including remotely-sensed chlorophyll a concentration (CHL), sea surface temperature, wind, solar radiation, precipitation, and aerosols. Shallow waters of northwestern Gulf influenced by Shatt Al-Arab River discharge were more productive than open Gulf waters, although seasonal CHL patterns in this and other shallow regions looked unrealistic likely because the CHL signal was obscured by bottom reflection. Therefore our further analyses focused on the open Gulf waters, which show a subtropical seasonal CHL cycle with maximum in winter and minimum in spring-summer. This cycle, however, was decoupled from the seasonal e...

British Library Electronic Table of Contents (United Kingdom)

Many of the world's coral reefs suffered high coral mortality during the 1998 ENSO, with the highest mortality in the western Indian Ocean (WIO). A meta-analysis of field data on change in coral cover across the 1998 ENSO event was conducted for 36 major reef areas in the WIO, and relationship of the change with the historical sea-surface temperature (SST) variability investigated. WIO reefs were categorized into three major SST groups of differing coral cover change. Cover change was negatively associated with standard deviation (SD) SST until about SD 2.3, with increasing flatness of the SST frequency distributions. It increased with further increase in SD as the SST distributions became strongly bimodal in the Arabian/Persian Gulf area. The study indicates that environmental resistance/...

British Library Electronic Table of Contents (United Kingdom)

Abstract In this first systematic attempt to characterize the intranight optical variability (INOV) of TeV-detected blazars, we have monitored a well-defined set of nine TeV blazars on total 26 nights during 2004-10. In this R- or V-band-monitoring programme only one blazar was monitored per night and the minimum duration was close to 4-h, the average being 5.3 h per night. Using the CCD for strictly simultaneous photometry of the blazar and nearby reference stars (N-star photometry), an INOV detection threshold of -1-2-per cent was achieved in the densely sampled differential light curves derived from our data. We have further expanded the sample by including another 13 TeV blazars, taking advantage of the availability in the literature of INOV data, including those published earlier in o...

British Library Electronic Table of Contents (United Kingdom)

A dense Pd-Ag membrane reactor (MR) with 100% hydrogen selectivity packed with either Rh/La2O3 or Rh/La2O3-SiO2 as catalysts was used to carry out the dry reforming of methane. The membrane reactor simulation was performed using a well-known reactor model. For this purpose, we employed the equations derived from complete kinetic studies of the dry reforming of methane reaction in connection with both catalysts. In addition, we developed the kinetic equation for the reverse water gas shift reaction (RWGS). The combination of detailed kinetic studies with the measured permeation flux for the Pd-Ag membrane allowed a complete comparison between experimental and simulated operation variables. The variables studied for both catalysts were methane conversion and hydrogen permeation as a function...

International Nuclear Information System (INIS)

The disrupted magnetic braking theory for the period gap of cataclysmic variable systems is used to study the binary evolution of low-mass main-sequence-like stars with white dwarf companions. The model is able to reproduce the observed location and width of the gap provided that the average mass transfer rates above the upper edge of the gap are greater than about 1.9 x 10 to the -9th solar masses/yr. For the case of angular momentum loss by magnetic braking, the slope of the mass transfer rate with respect to orbital period is shown to range from 3.4 to 3.7. For the evolutionary sequences considered, the He-3 abundance at the surface of the secondary exceeds 0.0015 after the complete mixing phase, resulting in modifications in the nuclear burning development of nova explosions. 31 refs.

British Library Electronic Table of Contents (United Kingdom)

Variability in production is one of the largest factors that negatively impacts construction project performance. A common construction practice to protect production systems from variability is the use of buffers (Bf). Construction practitioners and researchers have proposed buffering approaches for different production situations, but these approaches have faced practical limitations in their application. A multiobjective analytic model (MAM) is proposed to develop a graphical solution for the design of Work-In-Process (WIP) Bf in order to overcome these practical limitations to Bf application, being demonstrated through the scheduling of repetitive building projects. Multiobjective analytic modeling is based on Simulation?Optimization (SO) modeling and Pareto Fronts concepts. Simulation...

British Library Electronic Table of Contents (United Kingdom)

Estimates of climate change impacts are plague with uncertainties from many physical, biological, and social-economic processes. Among the urgent research priorities, more comprehensive assessments of impacts that better represent the uncertainties are needed. Here, we develop a new super-ensemble-based probabilistic projection approach to account for the uncertainties from CO2 emission scenarios, climate change scenarios, and biophysical processes in impact assessment model. We demonstrate the approach in addressing the probabilistic changes of maize production in the North China Plain in future. The new process-based general crop model, MCWLA [Tao, F., Yokozawa, M. Zhang, Z., 2009. Modelling the impacts of weather and climate variability on crop productivity over a large area: a new proc...

International Nuclear Information System (INIS)

Short-duration measurements have been widely used to screen for exposures to elevated radon concentrations in individual houses or at state or regional levels. However, a number of factors, including spatial and temporal variability in radon concentrations, must be considered before comparison to concentration guidelines can be made. Daily variations in radon concentration can lead to inherent measurement uncertainties ranging from 20 to 100+ percent. Differences in radon concentration due to seasonal effects and/or sampling location are also variable, and do not appear to be regionally consistent. Winter/summer concentration ratios, for example, have been observed to vary by as much as a factor of 10 in basements and by a factor of 5 in first floors. In this paper the implications of these uncertainties on the use of short-term sampling for inferring long-term exposures are discussed.

British Library Electronic Table of Contents (United Kingdom)

Abstract The Eiffel Tower edifice is situated in the Lucky Strike hydrothermal vent field at a mean depth of 1690-m on the Mid-Atlantic Ridge (MAR). At this 11-m-high hydrothermal structure, different faunal assemblages, varying in visibly dominant species (mussels and shrimp), in mussel size and in density of mussel coverage, were sampled biologically and chemically. Temperature and sulphide (-S) were measured on the different types of mussel-based assemblages and on a shrimp-dominated assemblage. Temperature was used as a proxy for calculating total concentrations of CH4. Based on the physico-chemical measurements, two microhabitats were identified, corresponding to (i) a more variable habitat featuring the greatest fluctuations in environmental variables and (ii) a second, more stable, ...

British Library Electronic Table of Contents (United Kingdom)

In this study, usage of a variable speed refrigeration system in latent heat thermal energy storage (LHTES) system is investigated to increase energy storage efficiency. Four different compressor speed control cases are compared to obtain a constant heat transfer fluid (HTF) temperature at the inlet of the energy storage tank. These control cases are (i) control with evaporation temperature, (ii) control with ethylene glycol temperature at the outlet section of evaporator, (iii) control with suction pressure of the compressor and (iv) on/off control. By means of the experimental analysis the best control strategy is obtained as control with Case (ii), in terms of stability of inlet temperature of heat transfer fluid, variations of energy efficiency of LHTES and coefficient of performance (...

British Library Electronic Table of Contents (United Kingdom)

The objective of this study is to analyze the effects of heat loss characterized by a percentage of the fuel's energy, friction and variable specific heats of working fluid on the performance of an air standard Otto cycle with a restriction of maximum cycle temperature. A more realistic and precise relationship between the fuel's chemical energy and the heat leakage that is based on a pair of inequalities is derived through the resulting temperature. The variations in power output and thermal efficiency with compression ratio, and the relations between the power output and the thermal efficiency of the cycle are presented. The results show that the power output as well as the efficiency where maximum power output occurs will increase with increase of the maximum cycle temperature. The temp...

CERN Document Server

In this paper we examine the relationship between covariance and unitarity for quantum gravity in Ashtekar variables. A usual description would discard half of the original Lorentz group, in exchange for the resulting simplifications of general relativity. We start by quantizing a trivial SL(2,C) gauge theory resulting in a nonunitary covariant theory. By the addition of a total time derivative we transform this into a unitary theory of the Ashtekar description of gravity with complete accountability of the degrees of freedom. We find that covariance on the spacetime level bears a direct relationship to covariance on the level ofthe quantum fields themselves. This procedure can in principle be applied to any totally constrained system, and bears a resemblance to the Gupta--Bleuler method. Finally, we make some observation regarding the loop representation of the SL(2,C) connection.

Science.gov (United States)

A multivariate bioprocess control approach, capable of tracking a pre-set process trajectory correlated to the biomass or product concentration in the bioprocess is described. The trajectory was either a latent variable derived from multivariate statistical process monitoring (MSPC) based on partial least squares (PLS) modeling, or the absolute value of the process variable. In the control algorithm the substrate feed pump rate was calculated from on-line analyzer data. The only parameters needed were the substrate feed concentration and the substrate yield of the growth-limiting substrate. On-line near-infrared spectroscopy data were used to demonstrate the performance of the control algorithm on an Escherichia coli fed-batch cultivation for tryptophan production. The controller showed good ability to track a defined biomass trajectory during varying process dynamics. The robustness of the control was high, despite significant external ...

Energy Technology Data Exchange (ETDEWEB)

Three geothermal direct heat applications were examined to derive a set of cost estimates from which one could determine the effect of changes in system parameters (temperature, flow, load, etc.) on the cost of heat. For each application, a set of resource characteristics and system inputs were chosen to best represent a site specific baseline condition. The baseline estimated cost of heat was calculated along with other cost estimates representing optimistic and pessimistic conditions, bracketing the range any input variable might reasonably take. Regression equations based upon these cost estimates were developed for each application to quantitatively relate changes in cost to changes in the input variables. These three equations and their accompanying nomographs serve as easily understandable planning tools for direct heat geothermal energy projects.

British Library Electronic Table of Contents (United Kingdom)

Abstract Objective:- This study explored 12-month outcome and its associations to social adjustment-related variables in patients with first-episode non-affective psychosis in Finland and Spain. Methods:- Forty-nine Finnish and 37 Spanish patients were evaluated at admission on various characteristics of social adjustment. Outcome was measured for 68 (79%) patients by the Brief Psychiatric Rating Scale, Global Assessment Scale, and Grip on Life. Results:- One-fourth of the patients experienced psychotic symptoms at follow-up. Sixty per-cent of the patients showed good global functioning and Grip on Life. In both patient groups, poor earlier global functioning, weak social network, poor Grip on Life, and psychological dependence on family of origin were associated with poor outcome. In the ...

Energy Technology Data Exchange (ETDEWEB)

This work has analyzed the key variables of indentation tip radius, contact radius, delamination radius, residual stress and superlayer/film/interlayer properties on nanoindentation measurements of adhesion. The goal to connect practical works of adhesion for very thin films to true works of adhesion has been achieved. A review of this work titled ''Interfacial toughness measurements of thin metal films,'' which has been submitted to Acta Materialia, is included.

Energy Technology Data Exchange (ETDEWEB)

This article describes the state-of-the-art HVAC system at the Philadelphia Marriott Hotel. Thermal comfort and indoor air quality are emphasized. The system uses a hybrid gas absorption/electric centrifugal chilled water plant, variable flow pumping, water-side economizers to provide free cooling, central air handling units with air-side economizers and flow monitoring equipment.

CERN Document Server

Given a random variable $F$ regular enough in the sense of the Malliavin calculus, we are able to measure the distance between its law and almost any continuous probability law on the real line. The bounds are given in terms of the Malliavin derivative of $F$. Our approach is based on the theory of It\\^o diffusions and the stochastic calculus of variations. Several examples are considered in order to illustrate our general results.

Energy Technology Data Exchange (ETDEWEB)

Cellulose raw materials costs must be considered in order to obtain a minimized hexose cost. In recognition of this fact, it may be economically advantageous to operate at less than maximum hexose concentration in the reactor and to recycle unreacted cellulose. The objective of this article is to optimize a cellulose-recycle reactor system for producing hexose at minimum cost. A sensitivity analysis of the important variables in the mathematical model of this system is also discussed.

Science.gov (United States)

Resistance exercise has been widely reported to have positive rehabilitation effects for patients with neuromuscular and orthopaedic conditions. This paper presents an optimal design of magneto-rheological fluid dampers for variable resistance exercise devices. Adaptive controls for regulating the resistive force or torque of the device as well as the joint motion are presented. The device provides both isometric and isokinetic strength training for various human joints.

Science.gov (United States)

One of the main goals in the operation of a cupola furnace is to keep the molten iron properties within prescribed bounds while maintaining the most economical operation for the cupola. In this paper the authors present a procedure to obtain the nominal values for the manipulated process variables. The nominal values are calculated by solving a constrained nonlinear programming optimization problem. Two different optimization problems are discussed and examples for using the procedure are presented.

Energy Technology Data Exchange (ETDEWEB)

This paper outlines the development of an organizational model which will be used to determine the influence of supervisory and management functions in a nuclear power plant (NPP) on risk. A theoretical conceptualization, derived from the empirical literature, is used to describe the organizational structure of NPPs. The parameters and variables associated with this dynamic, process-oriented model are detailed. Applications of the model and preliminary insights derived from this conceptualization are discussed.

International Nuclear Information System (INIS)

A mathematical and physical model was constructed describing the hydrodynamics of the two-phase mixture in the horizontal steam generator. The HP 9830 A desk-top calculator was used for the computations. The output variable of the solution was the level shape. A quantitative and qualitative comparison was made of the results of computations and experimental data. (author).

Science.gov (United States)

We report the of the existence of RV Tauri stars in the Large Magellanic Cloud (LMC). This class of variable star has hitherto been unidentified in the Magellanic Clouds. In light and color curve behavior the RV Tauri stars appear to be an extension of the Type II Cepheids to longer periods. A single period-luminosity-color relationship is seen to describe both the Type II Cepheids and the RV Tauri stars in the LMC.

International Nuclear Information System (INIS)

The feasibility of using a thermoplastic-powder metallurgy technique for the fabrication of porous niobium rods was investigated. Some early problems were overcome to successfully extrude the polymer coated niobium powder into long lengths. The effects of certain process variables were investigated. Residual porosity and extrusion pressure were found to be regulated by the polymer fraction. The procedures for taking the extruded polystyrene--niobium rods through the heat treatments to the final, tin infiltrated stage are explained.

Energy Technology Data Exchange (ETDEWEB)

The hierarchy of integrable nonlinear equations associated with the quadratic bundle is considered. The expressions for the solution of linearization of these equations and their conservation law in the terms of solutions of corresponding Lax pairs are found. It is shown for the first member of the hierarchy that the conservation law is connected with the solution of linearized equation due to the Noether's theorem. The local hierarchy and three nonlocal ones of the infinitesimal symmetries and conservation laws explicitly expressed through the variables of the nonlinear equations are derived. (author)

Energy Technology Data Exchange (ETDEWEB)

Biomedical science researchers often express frustration that health physics practices vary widely between individual institutions. A survey examining both internal and external dose assessment practices was devised and mailed to fifty institutions supporting biomedical science research. The results indicate that health physics dose assessment practices and policies are highly variable. Factors which may contribute to the degree of variation are discussed. 2 tabs.

Science.gov (United States)

Analyzing the risk of a safeguards system, in particular the security of a computer network based on the notion of fuzzy sets and linguistic variables, addresses concerns such as complexity and inherent imprecision in estimating the possibility of loss or compromise. Automated risk analysis allows the risk to be determined for an entire system based on estimates for lowest level components and the component weight. In addition, for each component (asset) we select the most effective combination of protection mechanisms against a given set of threats.

UK PubMed Central (United Kingdom)

BackgroundStudies of chronic health effects due to exposures to particulate matter with aerodynamic diameters ≤ 2.5 μm (PM_2.5) are often limited by sparse...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

Energy conservative building design has triggered greater interests in developing flexible and sophisticated air conditioning systems capable of achieving enhanced energy-savings potential without sacrificing the desired thermal comfort and indoor air quality (IAQ). This research work greatly aimed at achieving enhanced energy conservation, good thermal comfort and better IAQ for space conditioning with the application of combined variable refrigerant volume (VRV) and variable air volume (VAV) air conditioning (A/C) systems. Experimental investigation on the proposed combined air conditioning system with the application of intelligent fuzzy logic controller was performed for summer and winter climatic conditions to substantiate the energy-savings capability. The proposed system experimentally analyzed under fixed ventilation, demand controlled ventilation (DCV) and combined DCV and economizer cycle (EC) ventilation techniques effectively ...

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Electrochemical cyclic potentiodynamic polarization (CPP) experiments were performed on several candidate high-performance waste package container materials to evaluate their susceptibility to localized corrosion in aqueous environments relevant to the potential underground high-level nuclear waste repository. This paper presents the results of this study showing the effects of chloride ion (Cl) concentrations, pH, temperature, and electrochemical potential scan rate on the pitting corrosion behavior of these materials.

UK PubMed Central (United Kingdom)

ABSTRACTThe immune response to Neisseria gonorrhoeae is poorly understood, but its extensive antigenic variability and resistance to complement are thought to allow it...Full Text Available

UK PubMed Central (United Kingdom)

Cystic fibrosis (CF) is a monogenic disease characterized by a high variability of disease severity and outcome that points to the role of environmental factors and modulating genes that shape the course...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

A non-recursive model is proposed and empirically tested with data of opponents of nuclear power. In explaining conventional and unconventional participation the theory of collective action is applied and modified in two respects: the perceived influence on the elimination of collective evils are taken into account; the selective incentives considered are non-material ones. These modifications proved to be valid: the collective good variables and non-material incentives were important determinants for the two forms of participation. Another result was that there is a reciprocal causal relationship between conventional and unconventional participation.

International Nuclear Information System (INIS)

The possible existence of preferential B-site disorder in A-15 compounds recently claimed on the basis of x-ray powder diffraction data but questioned from the viewpoint of known phase diagrams is examined for some Nb-based compounds of this type. It is concluded that x-ray powder data do not allow the determination of both order and compositional variables as suggested, and the latter must therefore be determined by some other method. (author).

Science.gov (United States)

RP-1 is a long-established hydrocarbon fuel that continues to be widely used as the kerosene component in rocket propulsion systems. The desire in recent years to use rocket motors many times, rather than a single time, has led to reformulations of RP-1. ...

Science.gov (United States)

The report gives results of a pilot-plant study of the ammonia absorption/ammonium bisulfate regeneration process for removing SO2 from the stack gas of coal-fired power plants. Data were developed on the effects of such operating variable in the absorption of SO2 by ammoniacal l...

Energy Technology Data Exchange (ETDEWEB)

The control problem associated to a class of horizontal-axis fixed-pitch variable-speed low-power wind energy conversion systems, working in the partial load region, consisting in the energy conversion maximization, is approached here under the assumption that the wind turbine model and its parameters are poorly known. Using a new approach derived from the optimum seeking methods category, generically called Maximum Power Point Tracking (MPPT), the proposed control solution aims at driving the average position of the operating point near to optimality. Instead of inducing sinusoidal search signals, the wind turbulence is here used as search disturbance. The high-speed shaft's average rotational speed is slowly adjusted using the Fast Fourier Transform processing of some available measures from the system as an estimate of the operating point's position/distance to optimality. Numerical simulations are used for preliminary checking the control law ...

CERN Document Server

The nature of the hard X-ray source XSSJ12270-4859 is still unclear though it was claimed to be a magnetic Cataclysmic Variable. We here present a broad-band X-ray and gamma ray study based on a recent XMM-Newton observation and archival INTEGRAL and RXTE data. From the Fermi/LAT 1-year point source catalogue, we tentatively associate XSSJ12270-4859 with 1FGLJ1227.9-4852, a source of high energy gamma rays with emission up to 10GeV. We complement the study with UV photometry from XMM-Newton and ground-based optical and near-IR photometry. The X-ray emission is highly variable showing flares and intensity dips. The X-ray flares consist of flare-dip pairs. Flares are also detected in the UV range but not the dips. Aperiodic dipping behaviour is also observed during X-ray quiescence but not in the UV. The 0.2-100keV spectrum is featureless and described by a power law model with Gamma=1.7. The 100MeV-10GeV spectrum is instead represented by a ...

CERN Document Server

I review what we know about the donor stars in cataclysmic variables (CVs), focusing particularly on the close link between these binary components and the overall secular evolution of CVs. I begin with a brief overview of the "standard model" of CV evolution and explain why the key observables this model is designed to explain - the period gap and the period minimum -- are intimately connected to the properties of the secondary stars in these systems. CV donors are expected to be slightly inflated relative to isolated, equal-mass main-sequence (MS) stars, and this "donor bloating" has now been confirmed observationally. The empirical donor mass-radius relationship also shows a discontinuity at M_2 = 0.2 M_sun which neatly separates long- and short-period CVs. This is strong confirmation of the basic disrupted magnetic braking scenario for CV evolution. The empirical M_2-R_2 relation can be combined with stellar models to construct a complete, semi-empirical donor ...

CERN Document Server

We report results of the 2006 April multi-wavelengths campaign of SS 433, focusing on X-ray data observed with Suzaku at two orbital phases (in- and out-of- eclipse) and simultaneous optical spectroscopic observations. By analyzing the Fe25 K_alpha lines originating from the jets, we detect rapid variability of the Doppler shifts, dz/dt ~ 0.019/0.33 day^-1, which is larger than those expected from the precession and/or nodding motion. This phenomenon probably corresponding to "jitter" motions observed for the first time in X-rays, for which significant variability both in the jet angle and intrinsic speed is required. From the time lag of optical Doppler curves from those of X-rays, we estimate the distance of the optical jets from the base to be ~(3-4) \\times 10^14 cm. Based on the radiatively cooling jet model, we determine the innermost temperature of the jets to be T_0 = 13 +/- 2 keV and 16 +/- 3 keV (the average of the blue and red jets) ...

Science.gov (United States)

This dissertation reports on the application of numerical optimization techniques as applied to fuel cell simulation and design. Due to the "multi-physics" inherent in a fuel cell, which results in a highly coupled and non-linear behavior, an experimental program to analyze and improve the performance of fuel cells is extremely difficult. This program applies new optimization techniques with computational methods from the field of aerospace engineering to the fuel cell design problem. After an overview of fuel cell history, importance, and classification, a mathematical model of solid oxide fuel cells (SOFC) is presented. The governing equations are discretized and solved with computational fluid dynamics (CFD) techniques including unstructured meshes, non-linear solution methods, numerical derivatives with complex variables, and sensitivity analysis with adjoint methods. Following the validation of the fuel cell model in 2-D and 3-D, the results of the sensitivity ...

Science.gov (United States)

The main objectives were to evaluate efficacy and acceptability of a developmentally sensitive cognitive behavioral therapy for anxiety-based school refusal in adolescence. Twenty school-refusing adolescents meeting DSM-IV anxiety disorder criteria participated in a non-randomized trial, together with parents and school staff. Outcome was assessed at post-treatment and 2-month follow-up. Treated adolescents showed significant and maintained improvements across primary outcome variables (school attendance; school-related fear; anxiety), with medium to large effect sizes. Half of the adolescents were free of any anxiety disorder at follow-up. Additional improvements were observed across secondary outcome variables (depression; overall functioning; adolescent and parent self-efficacy). The treatment was rated as acceptable by adolescents, parents, and school staff, which may help explain the very low attrition rate. Social anxiety disorder was the ...