International Nuclear Information System (INIS)

Macrophage differentiation antigen associated with complement three receptor function (Mac-1) belongs to #beta#_2 subfamily of integrins that mediate important cell-cell and cell-extracellular matrix interactions. Biochemical studies have indicated that Mac-1 is a constitutive heterodimer in vitro. Here, we detected the heterodimerization of Mac-1 subunits in living cells by means of two fluorescence resonance energy transfer (FRET) techniques (fluorescence microscopy and fluorescence spectroscopy) and our results demonstrated that there is constitutive heterodimerization of the Mac-1 subunits and this constitutive heterodimerization of the Mac-1 subunits is cell-type independent. Through FRET imaging, we found that heterodimers of Mac-1 mainly localized in plasma membrane, perinuclear, and Golgi area in living cells. Furthermore, through analysis of the estimated physical distances between cyan fluorescent protein (CFP) and yellow fluorescent protein (YFP) fused ...

DEFF Research Database (Denmark)

Udgivelsesdato: 2001-Mar

UK PubMed Central (United Kingdom)

β₂ integrins are of critical importance for leukocyte extravasation through vascular endothelia and for T cell activation. To elucidate the role of β₂ integrins...Full Text Available

British Library Electronic Table of Contents (United Kingdom)

The International Index of Erectile Function is a well-worded and psychometrically valid self-report questionnaire widely used as the standard for the evaluation of male sexual function. However, some conceptual and statistical problems arise when using the measure with men who are not sexually active. These problems are illustrated using 2 empirical examples, and the authors provide recommended solutions to further strengthen the efficacy and validity of this measure.

Science.gov (United States)

... The basal markers CK5, alpha 6 integrin (CD49f), CD44, and p63 were strongly expressed by the majority of sphere-forming cells. ... p63 p63 PSCA ...

British Library Electronic Table of Contents (United Kingdom)

The purpose of this study was to assess the utility of the Arabic translation of the Alcohol Use Disorders Identification Test (AUDIT) among a sample of male Muslim prisoners (N = 107) in Dubai, United Arab Emirates (UAE). Confirmatory factor analysis indicated a two-factor model to be the best fit of the data. Good internal reliability (a =.91) and predictive validity were also observed. While the limitations of the study are observed, these promising results suggest that the Arabic version of the AUDIT is a reliable and sound measure of alcohol use disorders among prisoners in the UAE.

CERN Document Server

In this paper, we intend to formulate a new metaheuristic algorithm, called Cuckoo Search (CS), for solving optimization problems. This algorithm is based on the obligate brood parasitic behaviour of some cuckoo species in combination with the Levy flight behaviour of some birds and fruit flies. We validate the proposed algorithm against test functions and then compare its performance with those of genetic algorithms and particle swarm optimization. Finally, we discuss the implication of the results and suggestion for further research.

UK PubMed Central (United Kingdom)

Neuropilin 1 (Nrp1) is a coreceptor for vascular endothelial growth factor A165 (VEGF-A165, VEGF-A164 in mice) and semaphorin 3A (SEMA3A). Nevertheless, Nrp1 null embryos display vascular...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

Verification, calibration, and validation (VCV) of Computational Fluid Dynamics (CFD) codes is an essential element of the code development process. The exact manner in which code VCV activities are planned and conducted, however, is critically important. It is suggested that the way in which code validation, in particular, is often conducted--by comparison to published experimental data obtained for other purposes--is in general difficult and unsatisfactory, and that a different approach is required. This paper describes a proposed methodology for CFD code VCV that meets the technical requirements and is philosophically consistent with code development needs. The proposed methodology stresses teamwork and cooperation between code developers and experimentalists throughout the VCV process, and takes advantage of certain synergisms between CFD and experiment. A novel approach to uncertainty analysis is described which can ...

Energy Technology Data Exchange (ETDEWEB)

A common practice of electric utilities experiencing transmission and distribution (T and D) system overloads is to expand the substation, add lines, or upgrade equipment, all of which are capital intensive options. In 1988, it was hypothesized that strategically sited photovoltaics (PV) could benefit parts of T and D systems near or at overloaded conditions. An evaluation methodology was developed and applied to a test case (Kerman Substation near Fresno, California). Analytical results suggested that the value of PV to the T and D system could substantially exceed its energy and generation capacity value. The importance of this finding indicated the need for empirical validation. This led to the construction of a 0.5 MW PV demonstration plant by Pacific Gas and Electric Company (PG and E) at Kerman, California as part of the PVUSA (PV for Utility Scale Applications) project. PVUSA is a national public-private partnership that is assessing and ...

International Nuclear Information System (INIS)

Various schemes of cooling have been investigated for the purpose of assessing potential benefits on the operational characteristics of the Syrian MNSR reactor. A detailed thermal hydraulic model for the analysis of MNSR has been developed. The analysis shows that an auxiliary cooling system, installed in the pool which surrounds the lower section of the reactor vessel, will significantly offset the consumption of excess reactivity due to the negative reactivity temperature coefficient, Hence, the maximum operating time of the reactor is extended. Compared with experimental data, the suggested model proves to be valid for the analysis of MNSR behavior under both steady state and transient conditions. (author)

Science.gov (United States)

The aims of the study were to develop and test the psychometric properties of the Thai Family Health Routines (TFHR) scale, a 70-item self-report questionnaire used to measure the health of Thai families through their routine behaviors in daily life. Development of the TFHR was based on the structural domains of Denham's Family Health Model. The TFHR scale was initially composed of 85 items and tested on 1,040 families living in the central region of Thailand. The confirmatory factor analysis, with an acceptable factor structure model, yielded 70 items aligned with six factors: self-care, safety and prevention, mental health behavior, family care, family caregiving, and illness care routines. The preliminary psychometric properties demonstrated that the TFHR scale had satisfactory internal consistency, criterion validity, and construct validity. The test results suggested that the TFHR scale has potential benefits for ...

Science.gov (United States)

Four-enzyme section of the shikimate pathway (Aro B, D, E, and K) of Streptococcus pneumoniae has been studied. Kinetic properties of the individual enzymes and three- and four-enzyme linked reactions have been characterized in vitro. On the basis of the data measured in spectrophotometric and LC-MS experiments, kinetic mechanisms of the enzymes have been suggested and all kinetic parameters have been identified. Kinetic models for these three- and four-enzyme sections of the shikimate pathway have been constructed and validated. The model of the four-enzyme section of shikimate pathway has been employed to design an inhibition-sensitive reconstituted pathway for a high-throughput screening effort on the shikimate pathway. It was demonstrated that using the model it was possible to optimize this reconstituted pathway in such a way to provide equal sensitivity of the enzymes to inhibition. PMID:16921527

British Library Electronic Table of Contents (United Kingdom)

Eight selected sulfonamide drugs were investigated as inhibitors of heat shock protein 90 (Hsp90). The investigation included simulated docking experiments to fit the selected compounds within the binding pocket of Hsp90. The selected molecules were found to readily fit within the ATP-binding pocket of Hsp90 in low-energy poses. The sulfonamides torsemide, sulfathiazole, and sulfadiazine were found to inhibit the ATPase activity of Hsp90 with IC50 values of 1.0, 2.6, and 1.5 mM, respectively. Our results suggest that these well-established sulfonamides can be good leads for subsequent optimization into potent Hsp90 inhibitors.

Science.gov (United States)

In this article, we propose a model selection method, the Bayesian composite model space approach, to map quantitative trait loci (QTL) in a half-sib population for continuous and binary traits. In our method, the identity-by-descent-based variance component model is used. To demonstrate the performance of this model, the method was applied to map QTL underlying production traits on BTA6 in a Chinese half-sib dairy cattle population. A total of four QTLs were detected, whereas only one QTL was identified using the traditional least square (LS) method. We also conducted two simulation experiments to validate the efficiency of our method. The results suggest that the proposed method based on a multiple-QTL model is efficient in mapping multiple QTL for an outbred half-sib population and is more powerful than the LS method based on a single-QTL model. PMID:21487433

Energy Technology Data Exchange (ETDEWEB)

Although the radioreceptor method is widely used for estrogen receptor assay in human tissue, it has several limitations and a number of alternative methods are being explored. An immunohistochemical method of estrogen receptor assay using a specific antibody to estradiol has been proposed as a suitable alternative. The present study was designed to evaluate the validity of this method in detecting true estrogen receptors in human tumor tissue. Using radioiodinated antibody to estrogen, we have demonstrated that the estrogen antibody can detect the estrogen when it is bound to 4S type receptor but is unable to bind to estrogen when the hormone is bound to 8S type receptor. Our observations suggest that the immunohistochemical method of detection of intracellular cytosolic receptor for estrogen is not a suitable alternative to the currently used radioreceptor method.

British Library Electronic Table of Contents (United Kingdom)

This study validates a research model that examines usage of instant messaging (IM) from the aspect of online social support. Drawing on the social capital theory, this study postulates that IM usage is indirectly affected by social support via the mediation of the following six dimensions of social capital: commitment, reciprocity, shared codes and language, shared narratives, centrality, and network ties. The model tests data obtained from business organizations in Taiwan, and the results suggest that the indirect influence of social support on IM usage through shared codes and language is significant, and the indirect influence of social support on IM usage through centrality is also significant. Managerial implications and limitations of the empirical findings are provided.

British Library Electronic Table of Contents (United Kingdom)

Many aspects of cellular motility and mechanics are cyclic in nature such as the extension and retraction of lamellipodia or filopodia. Inherent to the cycles of extension and retraction that test the environment is the production of mechano-chemical signals that can alter long-term cell behavior, transcription patterns, and cell fate. We are just starting to define such cycles in several aspects of cell motility, including periodic contractions, integrin cycles of binding and release as well as the normal oscillations in motile activity. Cycles of local cell contraction and release are directly coupled to cycles of stressing and releasing extracellular contacts (matrix or cells) as well as cytoplasmic mechanotransducers. Stretching can alter external physical properties or sites exposed b...

UK PubMed Central (United Kingdom)

ObjectiveIn the context of the importance of valid self-report measures to research and evidence-based practice in social work, an argument-based approach to validity...Full Text Available

Science.gov (United States)

... VALIDATING NETWORK SECURITY POLICIES VIA STATIC ANALYSIS OF ROUTER ACL CONFIGURATION by Eric Gregory Wen Wei Wong ...

Science.gov (United States)

This research validates a novel approach for source tracking based on denaturing gradient gel electrophoresis (DGGE) analysis of DNA extracted from Escherichia coli isolates. Escherichia coli from different animal sources and from river samples upstream from, at, and downstream of a combined sewer overflow were subjected to DGGE to determine sequence variations within the 16S-23S intergenic spacer region (ISR) of the rrnB ribosomal operon. The ISR was analyzed to determine if E. coli isolates from various animal sources could be differentiated from each other. DNA isolated from the E. coli animal sources was PCR amplified to isolate the rrnB operon. To prevent amplification of all 7 E. coli ribosomal operons by PCR amplification using universal primers, sequence-specific primers were utilized for the rrnB operon. Another primer set was then used to prepare samples of the 16S-23S ISR for DGGE. Comparison of PCR-DGGE results between human and animal sources revealed ...

Energy Technology Data Exchange (ETDEWEB)

Non-first order (FO) kinetics models are of three types; second order (SO), general order (GO) and mixed order (MO). It is shown that all three of these have constraints in their energy level schemes and their applicable parameter values. In nature such restrictions are not expected to exist. The thermoluminescence (TL) glow peaks produced by these models shift their position and change their shape as the trap occupancies change. Such characteristics are very unlike those found in samples of real materials. In these models, in general, retrapping predominates over recombination. It is shown that the quasi-equilibrium (QE) assumption implied in the derivation of the TL equation of these models is quite valid, thus disproving earlier workers' conclusion that QE cannot be held under retrapping dominant conditions. However notwithstanding their validity, they suffer from the shortcomings as stated above and have certain lacunae. For ...

Energy Technology Data Exchange (ETDEWEB)

With using artificial neural networks (ANNs), an analytical study related to the heated length effect on critical heat flux (CHF) has been carried out to make an improvement of the CHF prediction accuracy based on local condition correlations or table. It has been carried out to suggest a feasible criterion of the threshold length-to-diameter (L/D) value in which heated length could affect CHF. And within the criterion, a L/D correction factor has been developed through conventional regression. In order to validate the developed L/D correction factor, CHF experiments for various heated lengths have been carried out under low and intermediate pressure conditions. The developed threshold L/D correlation provides a new feasible criterion of L/D threshold value. The developed correction factor gives a reasonable accuracy for the original database, showing the error of -2.18% for average and 27.75% for RMS, and promising results for new experimental ...

Energy Technology Data Exchange (ETDEWEB)

Radon exposure assessment in case-control studies on radon and lung cancer is generally based on contemporary radon concentration measurements, which can be affected by significant changes in the building structures or in living habits. Another method to estimate the radon exposure of the subjects is the recently developed retrospective dosimetry technique based on the {sup 210}Po surface activity from glass objects. In order to compare the results obtained by the two methods, a study has been carried out in a sample of 26 dwellings in Rome, with radon concentration values ranging from 28 to 623 Bq m{sup -3}. Retrospective detectors based on CR-39 and LR 115 were exposed on 50 glass objects in bedrooms and living rooms. The correlation factor between the two sets of data, after removing six extreme values, is 0.67, which is similar to results obtained in other validation studies of similar sample size. The correlation increases to 0.83 if the 21 objects exposed in ...

KoreaScience (Korea)

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KoreaScience (Korea)

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Energy Technology Data Exchange (ETDEWEB)

Because every cell within the body has the same genetic information, a significant problem in biology is to understand how cells within a tissue express genes selectively. A sophisticated network of physical and biochemical signals converge in a highly orchestrated manner to bring about the exquisite regulation that governs gene expression in diverse tissues. Thus, the ultimate decision of a cell to proliferate, express tissue-specific genes, or apoptose must be a coordinated response to its adhesive, growth factor, and hormonal milieu. The unifying hypothesis examined in this overview is that the unit of function in higher organisms is neither the genome nor the cell alone but the complex, three-dimensional tissue. This is because there are bidirectional connections between the components of the cellular microenvironment (growth factors, hormones, and extracellular matrix) and the nucl2048 These connections are made via membrane-bound receptors and transmitted to the nucleus, where ...

UK PubMed Central (United Kingdom)

BackgroundThe objective of this study was to develop and validate a daily electronic Endometriosis Pain and Bleeding Diary (EPBD) for assessing treatment-related changes in endometriosis...Full Text Available

UK PubMed Central (United Kingdom)

The validation parameters for pharmaceutical analyses were examined for the accelerator mass spectrometry measurement of ¹⁴C/C ratio, independent of chemical separation procedures....Full Text Available

Science.gov (United States)

... It is recommended that the drawings be validated in accordance with NAVAIRINST 4333.10 and the data package, Appendix A, be used for ...

Science.gov (United States)

... During operations, the system successfully treated Phosgene (CG), chloropicrin (PS), a smoke-generating formulation based on hexachloroethane ...

International Nuclear Information System (INIS)

Coronary angiography provides anatomical information whereas thellium myocardial scintigraphy measures resistive tissue perfusion. Because of this fundamental difference. The authors question the validity of using coronary angiography as the gold standard to judge thellium myocardial scintigraphy. The authors studied 20 patients undergoing elective percutaneous coronary angioplasty who fulfilled the following criteria: (1) history of chest pain; (2) angiographically significant single vessel disease (>50% stenosis); (3) no prior myocardial infarction. All patients underwent maximal exercise thallium single photon emission computed tomography (T1-SPECT). Tl-SPECT was scored visually according to a 0 to 3 scale (0=absent uptake; 1=markedly decreased uptake; 2=minimally decreased uptake; 3=normal uptake). Translesional gradient and percent stenosis were measured before and after angioplasty. The authors found that significant linear relationship exists between ...

International Nuclear Information System (INIS)

Full text: The general population is daily exposed to chronic, low doses of ionizing radiation (IR) from both natural and artificial sources. The biological consequences of acute, high dose IR exposure can be readily determined; however, the nature and significance of low dose, low dose-rate IR effects are still the subject of debate. Confounding the issue, are the phenomena collectively referred to as the Radiation-induced Bystander Effect (RIBE). The RIBE describes a collection of in vitro observations that suggest the presence of a soluble, transmissible factor(s) released from irradiated cells that can induce a biological response in un-irradiated cells. The induction, nature and magnitude of the RIBE varies between cell culture systems, radiation sources and end-points measured. Efforts to confirm the presence of the RIBE in vivo have been confined to in vivo-like culture systems and limited work with tumour and bone-marrow transplantation models. ...

Science.gov (United States)

Sixty-Hz magnetic field exposures were measured for 45 adult residents of Maine. Thirty of the subjects resided near rights-of-way (ROWs) with either 345- and 115-kV transmission lines, or ROWs with only 115-kV transmission lines; fifteen resided far from any transmission lines. Personal exposure data for a single 24-hour period was acquired with the EMDEX. The EMDEX's event-marker button was used to partition exposures into Home and Away components. Also, three area measurements were taken for each subject during the personal exposure measurement period: (1) 24-hr fixed-site bedroom measurement with a second EMDEX; (2) Spot measurements in at least three rooms of every residence; and (3) Spot measurements outside each residence. Residence near transmission lines highly loaded during the measurement period was associated with increased Home and Total exposure relative to a far-away population. Average exposure level while away from home was uniform (at about 2 mG) throughout ...

Energy Technology Data Exchange (ETDEWEB)

Fourier transform infrared absorption spectroscopy has been used for the determination of the line strengths of 41 CO and CO[sub 2] absorption lines at temperatures between 295 and 1250 K. The CO vibrational-rotational lines were from the [ital P] branch of the fundamental absorption band (2150--1950 cm[sup [minus]1]) while the CO[sub 2] vibrational-rotational lines were from the far wing of the [ital R] branch of the [nu][sub 3] fundamental band (2395--2380 cm[sup [minus]1]). The intensities of the lines were measured from absorption spectra recorded in a high-temperature gas cell containing known concentrations of CO/CO[sub 2]/N[sub 2] gas mixtures at atmospheric pressure. Absorption spectra were recorded through the cell with the use of a moderate-resolution Fourier transform infrared spectrometer. The absorption spectra were mathematically corrected for distortions resulting from the finite resolution of the spectrometer and for peak overlap. Line strength measurements were made ...

Energy Technology Data Exchange (ETDEWEB)

Aim: To investigate interpretative accuracy and reporting time for radiologists performing computed tomography (CT) colonography in day-to-day non-academic clinical practice. Materials and methods: Thirteen radiologists from seven centres, who were reporting CT colonography in non-academic daily clinical practice, interpreted a dataset of 15 colonoscopically validated cases in a controlled environment. Ten cases had either a cancer or polyp >10 mm; one case had a medium polyp and four were normal. Correct case categorization and interpretation times were compared using analysis of variance to aggregated results obtained from both experienced observers and observers recently trained using 50 cases, working in an academic environment. The effect of experience was determined using Spearman's rank correlation. Results: Individual accuracy was highly variable, range 53% (95% CI 27-79%) to 93% (95% CI 68-100%). Mean accuracy overall was significantly ...

Science.gov (United States)

Outbreaks of disease attributable to human error or natural causes can provide unique opportunities to gain new information about host-pathogen interactions and new leads for pathogenesis research. Poststreptococcal glomerulonephritis (PSGN), a sequela of infection with pathogenic streptococci, is a common cause of preventable kidney disease worldwide. Although PSGN usually occurs after infection with group A streptococci, organisms of Lancefield group C and G also can be responsible. Despite decades of study, the molecular pathogenesis of PSGN is poorly understood. As a first step toward gaining new information about PSGN pathogenesis, we sequenced the genome of Streptococcus equi subsp. zooepidemicus strain MGCS10565, a group C organism that caused a very large and unusually severe epidemic of nephritis in Brazil. The genome is a circular chromosome of 2,024,171 bp. The genome shares extensive gene content, including many virulence factors, with genetically related group A ...

DEFF Research Database (Denmark)

Background:The validity of dementia diagnoses in the Danish nationwide hospital registers was evaluated to determine the value of these registers in epidemiological research about dementia. Methods: Two hundred patients were randomly selected from 4,682 patients registered for the first time with a dementia diagnosis in the last 6 months of 2003. The patients' medical journals were reviewed to evaluate if they fulfilled ICD-10 and/or DSM-IV criteria for dementia and specific dementia subtypes. The patients who were still alive in 2006 were invited to an interview. Results: One hundred and ninety-seven journals were available for review and 51 patients were interviewed. A registered diagnosis of dementia was found to be correct in 169 (85.8%) cases. Regarding dementia subtypes, the degree of agreement between the registers and the results of the validating process was low with a kappa of 0.36 (95% CI 0.24-0.48). Conclusion: The ...

Science.gov (United States)

C. Learning Curve. The learning curve concept has long been recognized and ...... F4. TERMIA. S - STATION EQUIPMENT. V - VLBI VALIDATION EQUIPMENT ...

UK PubMed Central (United Kingdom)

BACKGROUND:In adults, it is well known that high levels of pain catastrophizing are related to increased pain and disability as well as to heightened anxiety and depression. However,...Full Text Available

UK PubMed Central (United Kingdom)

SynopsisAttention-deficit / hyperactivity disorder (ADHD) is a valid and impairing psychological disorder that persists into adulthood in a majority of cases and is associated...Full Text Available

CERN Document Server

Inferring cluster structure in microarray datasets is a fundamental task for the -omic sciences. A fundamental question in Statistics, Data Analysis and Classification, is the prediction of the number of clusters in a dataset, usually established via internal validation measures. Despite the wealth of internal measures available in the literature, new ones have been recently proposed, some of them specifically for microarray data. In this dissertation, a study of internal validation measures is given, paying particular attention to the stability based ones. Indeed, this class of measures is particularly prominent and promising in order to have a reliable estimate the number of clusters in a dataset. For those measures, a new general algorithmic paradigm is proposed here that highlights the richness of measures in this class and accounts for the ones already available in the literature. Moreover, some of the most representative ...

UK PubMed Central (United Kingdom)

BackgroundAdequate pain assessment is critical for evaluating the efficacy of analgesic treatment in clinical practice and during the development of new therapies. Yet the currently...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

2D simulation modeling of a river basin is based on notion of a River Basin as an opened non equilibrium nature system. All components of the system (elevation, water, soil properties and others) are linked to single multi - functional model. The objective of flood simulation is one the model functions. The objectives of the paper are as follows: a mean scale basin floods computing and the model validation; a large scale basin simulation and demands for its validation; results and demands for flood hazard assessment. (orig.)

Energy Technology Data Exchange (ETDEWEB)

Piping in nuclear power plants is vital to the proper operation and safety of these facilities. To assure safety in the unlikely event of a pipe break, it is necessary to evaluate the consequences from the resulting whipping pipe on neighboring components and structures. Numerical simulations allow for rapid evaluation of these consequences. Before simulations can be accepted, however, the methodology and computer codes must be validated against experimental results. This paper uses a probabilistic approach to validate pipe whip simulations against limited experimental results. Probabilistic analysis software was developed and coupled to existing deterministic finite element software. An example of a whipping pipe impacting against a reinforced concrete slab was simulated. The described probabilistic approach was used to validate the numerical simulations. The conclusions obtained were that the numerical simulations of ...

Science.gov (United States)

Three adolescents (ages 14-17) with emotional and behavioral disorders displayed chronic disruptive behavior in their self-contained classrooms at a self-contained alternative school. A descriptive functional behavioral assessment was conducted for each student. Data from file review, structured interviews, and direct observations were used to identify the functions of their disruptive behaviors. Then, function-based interventions were systematically constructed for each student and implemented for an extended period (nearly 6 weeks) within the most problematic situation in their classrooms. The interventions improved each student's behavior and the effects maintained during follow-up and generalized to instruction in a nonintervention classroom. Social validity data comparing the interventions to baseline practices revealed the function-based intervention had moderately higher social validity among teachers and substantially higher social ...

British Library Electronic Table of Contents (United Kingdom)

Purpose To examine the reliability and validity of the Japanese-language version of the PedsQL? Multidimensional Fatigue Scale and to investigate the agreement between child self-reported fatigue and parent proxy-reported fatigue. Methods The Japanese-language version of the PedsQL? Multidimensional Fatigue Scale was administered to 652 preschoolers and schoolchildren aged 5?12 and their parents, and to 91 parents of preschool children aged 1?4. Results Internal consistency reliability was 0.62?0.87 for children and 0.81?0.93 for parents. Known-group validity was examined between a group of healthy samples (n?=?530) and chronic condition sample (n?=?102); the chronically ill group reported a significantly higher perceived fatigue problem. Correlations between child self- and parent proxy r...

Science.gov (United States)

This paper details the design of a premixed, swirl-stabilized combustor that was designed and built for the express purpose of obtaining validation-quality data for the development of large eddy simulations (LES) of gas turbine combustors. The combustor features nonambiguous boundary conditions, a geometrically simple design that retains the essential fluid dynamics and thermochemical processes that occur in actual gas turbine combustors, and unrestrictive access for laser and optical diagnostic measurements. After discussing the design detail, a preliminary investigation of the performance and operating envelope of the combustor is presented. With the combustor operating on premixed methane/air, both the equivalence ratio and the inlet velocity were systematically varied and the flame structure was recorded via digital photography. Interesting lean flame blowout and resonance characteristics were observed. In addition, the combustor exhibited a large region of ...

British Library Electronic Table of Contents (United Kingdom)

As part of the United States Department of Agricultures (USDA) National Food and Nutrient Analysis Program (NFNAP), food composition data for vitamin D in the USDA National Nutrient Database for Standard Reference are being updated and expanded, focusing on high priority foods and validated analytical methodology. A lack of certified reference materials and analytical methods validated for these key foods required the development of five matrix-specific control composite materials (CC) (canned salmon and vitamin D3 fortified cereal, orange juice, milk, and cheese). Each of six experienced laboratories (research and commercial) analyzed vitamin D3 in five subsamples of each CC in five separate analytical batches, with one subsample of each material in each run. Research laboratories perform...

British Library Electronic Table of Contents (United Kingdom)

Piping in nuclear power plants is vital to the proper operation and safety of these facilities. To assure safety in the unlikely event of a pipe break, it is necessary to evaluate the consequences from the resulting whipping pipe on neighboring components and structures. Numerical simulations allow for rapid evaluation of these consequences. Before simulations can be accepted, however, the methodology and computer codes must be validated against experimental results. This paper uses a probabilistic approach to validate pipe whip simulations against limited experimental results. Probabilistic analysis software was developed and coupled to existing deterministic finite element software. An example of a whipping pipe impacting against a reinforced concrete slab was simulated. The described pr...

Energy Technology Data Exchange (ETDEWEB)

Unconditional estimates are suggested for the age of radioactive nuclei and hence for the age of the Universe.

UK PubMed Central (United Kingdom)

ObjectivesThe aim of this study was to assess the diagnostic and prognostic value of heart-type fatty acid-binding protein (H-FABP) in elective percutaneous coronary intervention...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

An important component of the overall program to validate WIMS-AECL for use with RFSP in the analysis of CANDU-6 reactors for design and safety analysis calculations is the validation of calculations of incremental cross sections used to represent reactivity devices. A method has been developed for the calculation of the three-dimensional neutron flux distribution in and around CANDU reactor fuel channels and reactivity control devices. The methods is based on one- and two dimensional transport calculations with the WIMS-AECL lattice cell code, SPH homogenization, and three-dimensional flux calculations with finite-difference diffusion theory using the MULTICELL code. Simulations of Wolsung 1 Phase-B commissioning measurements and Point Lepreau restart tests have been performed, as a part of the program to validate WIMS-AECL lattice cell calculations for application to CANDU reactor simulations in RFSP. The incremental ...

UK PubMed Central (United Kingdom)

BackgroundThe aim of this study is to validate the questionnaire ECOS-16 (Assessment of health related quality of life in osteoporosis) for the evaluation of health related quality...Full Text Available

UK PubMed Central (United Kingdom)

Sexual pressure among young urban women represents adherence to gender stereotypical expectations to engage in sex. Revision of the original 5-factor Sexual Pressure Scale was undertaken in...Full Text Available

Science.gov (United States)

Dippold, V., S. Mohler , Validation of the Wind-US Unstructured Flow Solver .... Hamed, A. and A. Mohamed, Assessment of Shock Induced Flow Separation and ...... Nozzles for Hypersonic Propulsion, NASA CR 185197, AGARD Symposium ...

UK PubMed Central (United Kingdom)

BackgroundTissue microarray (TMA) data are commonly used to validate the prognostic accuracy of tumor markers. For example, breast cancer TMA data have led to the identification...Full Text Available

UK PubMed Central (United Kingdom)

BackgroundThe aim of this study was to compare and to validate different dose calculation algorithms for the use in radiation therapy of small lung lesions and to optimize the treatment...Full Text Available

UK PubMed Central (United Kingdom)

AIMS—(1) To validate a leg to leg bioimpedance analysis (BIA) device in the measurement of body composition in children by assessment of its agreement with dual energy x...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

The biological accumulation of heavy metals and cesium, strontium, and uranium in plants is discussed. The role of nutrient deficiencies and foliar treatments of manganese and iron compounds is described.

UK PubMed Central (United Kingdom)

OBJECTIVE--To develop, test, and validate an algorithm for diagnosing disease in neonates during an over the telephone referral to a specialist cardiac centre. DESIGN--A draft algorithm requiring only...Full Text Available

UK PubMed Central (United Kingdom)

The use of digital wound images would allow remote consultation between patients, physicians, or other caregivers over the Internet. To evaluate the efficacy and validity of digital images for assessment...Full Text Available

UK PubMed Central (United Kingdom)

PurposeTo develop a generic instrument for measuring short-term health status in the recovery period among patients undergoing abdominal and pelvic surgery.Full Text Available

UK PubMed Central (United Kingdom)

BackgroundMany health care professionals use spinal palpatory exams as a primary and well-accepted part of the evaluation of spinal pathology. However, few studies have explored...Full Text Available

UK PubMed Central (United Kingdom)

All microRNA (miRNA) target—finder algorithms return lists of candidate target genes. How valid is that output in a biological setting? Transcriptome analysis has proven to be a useful approach...Full Text Available

UK PubMed Central (United Kingdom)

A nucleic acid extraction system that can handle small numbers of specimens with a short test turnaround time and short hands-on time is desirable for emergent testing. We performed a comparative validation...Full Text Available

Science.gov (United States)

... Page 2. Boston Scientific CRM 11/17/09 MADIT-CRT Clinical Report APPENDIX B 2 CONFIDENTIAL ... B-2 Primary Effectiveness B-2.1 Validation of Assumptions ...

Science.gov (United States)

include modeling geometric complexities, coupling between the flow and the .... noted that the AGARD 445.6 wing data set, which has been widely used for .... higher-level computational aeroelastic code validations at transonic flow separation ...

UK PubMed Central (United Kingdom)

Human arylamine N-acetyltransferase (NAT) activity is determined by two distinct genes, NAT1 and NAT2, and the classical acetylation polymorphism in NAT2 has been associated with a variety of disorders,...Full Text Available

UK PubMed Central (United Kingdom)

Large-scale cancer genome projects will soon be able to sequence many cancer genomes to comprehensively identify genetic changes in human cancer. Genome-wide association studies have also identified...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

A rigorous mathematical model is developed to describe chemical absorption of carbon dioxide in a falling-film micro-contactor. Contrary to previous models described in literature, hydrodynamics in both phases is accurately captured by the Navier-Stokes equations. By this means, backmixing effects can be accounted for. Furthermore, the interface position is determined directly using the level-set method. The developed model is validated with experimental data obtained from literature and a good agreement is established. With the validated model, detailed studies are performed to investigate the impact of process parameters.

Energy Technology Data Exchange (ETDEWEB)

One year of research on validating the performance of the Cable Monitoring and Rating System (CMARS) is reported. The performance testing was conducted on underground 230-kV and 345-kV pipe type cable circuits owned by the New Jersey Public Service Electric and Gas Co. Laser temperature monitoring systems and a data acquisition system were installed. Software installation and development is discussed. The CMARS testing program is described. (LCL)

Energy Technology Data Exchange (ETDEWEB)

Crack arrest of fast running cracks is an important issue for the safety of steel structures. Crack arrest design can prevent fatal damage of large structures by restricting the influence of the incidents. Therefore crack arrest design is important especially for very large structure, where accidents may cause huge economical and social losses. Propagating shear fracture, long running ductile crack propagation in pipelines and brittle crack propagation in heavy thick shipbuilding steels have been investigated. For the propagating shear fracture issue, a new HLP simulation model, applicable to various backfill conditions, including underwater backfill, was developed. The proposed backfill model can be applied to the prediction of the crack arrest of propagating shear fracture under various backfill conditions. The new HLP simulation was successful in estimating full-scale burst tests with various backfill depths. The new HLP simulation for underwater pipelines indicated that propagating ...

Science.gov (United States)

... While some measures were suggested as counseling tools to guide and influence ... it be awarded as part of the NCO Evaluation Report (NCOER). ...

Energy Technology Data Exchange (ETDEWEB)

As a maintenance optimization project to improve the safety of Wolsung NPP (Nuclear Power Plant), reliability of diesel generators are estimated based on the operating experience, and improvement options are suggested. A reliability measure is suggested for the estimation of reliability for standby safety systems to reflect availability. It is assessed that the reliability of diesel generators can be mush improved if the suggested improvement options are implemented. (Author) 6 refs., 1 tab.

Scientific Electronic Library Online (English)

Abstract in english The aim of this study was to verify validity and reliability of the scores for physical exercise in leisure (PEL), leisure and locomotion activities (LLA), and total score (TS) of the Baecke habitual physical activity questionnaire in adult males. Twenty-one students of Physical Education were evaluated. For validation, the maximum oxygen uptake (O2max) and the decrease of the heart rate in percentile (%DH (more) R) were measured through the Cooper's 12-minute walk or run test, and an annual index of physical exercise (IPE), and a week index of locomotion activities (ILA). The reliability was verified through test-retest with interval of 45 days. The Pearson correlation coefficient, and partial correlation adjusted for age and body mass index were used for validation. The intraclass correlation and paired t-test were used for reliability. The results indicated that %DHR was correlated with LLA and TS (r ...

International Nuclear Information System (INIS)

A CANDU nuclear reactor was shut down for over one year because steam generator (SG) tubes had failed with outer diameter stress-corrosion cracking (ODSCC) in the U-bend section. Novel, single-pass eddy current transmit-receive probes, denoted as C3, were successful in detecting all significant cracks so that the cracked tubes could be plugged and the unit restarted. Significant numbers of tubes with SCC were removed from a SG in order to validate the results of the new probe. Results from metallurgical examinations were used to obtain probability-of-detection (POD) and sizing accuracy plots to quantify the performance of this new inspection technique. Though effective, the above approach of relying on tubes removed from a reactor is expensive, in terms of both economic and radiation-exposure costs. This led to a search for more affordable methods to validate inspection techniques and procedures. Methods are presented for calculating POD curves ...

Energy Technology Data Exchange (ETDEWEB)

One approach to validate nuclear power plant (NPP) signals makes use of pattern recognition techniques. This approach often assumes that there is a set of signal prototypes that are continuously compared with the actual sensor signals. These signal prototypes are often computed based on empirical models with little or no knowledge about physical processes. A common problem of all data-based models is their limited ability to make predictions on the basis of available training data. Another problem is related to suboptimal training algorithms. Both of these potential shortcomings with conventional approaches to signal validation and sensor operability validation are successfully resolved by adopting a recently proposed learning paradigm called the support vector machine (SVM). The work presented here is a novel application of SVM for data-based modeling of system state variables in an NPP, integrated with a nonlinear, ...

Energy Technology Data Exchange (ETDEWEB)

The present paper is concerned with development and application of a so-called Effective Convection Model (ECM), which aims to provide a detailed, mechanistic description of heat transfer processes in a BWR lower plenum. The ECM is a Computational Fluid Dynamics (CFD)-like tool which employs a simpler and more effective approach to compute heat transfer by solving only energy conservation equation instead of solving the full set of Navier-Stokes and energy equations by a CFD code. We implement the ECM in a CFD code (Fluent), with detailed description of the ECM development, implementation and validation. A dual approach is used to validate the ECM, namely validation against experimental data and against heat transfer results obtained by CFD predictions in the same geometries and conditions. Insights gained from CFD simulations are also used to improve ECM. The ECM capability as an effective tool to simulate heat transfer of ...

International Nuclear Information System (INIS)

The most important commercialized methods of attenuation correction in SPECT are based on attenuation coefficient map from a transmission imaging method. The transmission imaging system can be the linear source of radioelement or a X-ray CT system. The image of transmission imaging system is not useful unless to replacement of the attenuation coefficient or CT number with the attenuation coefficient in SPECT energy. In this paper we essay to evaluate the validity and estimate the error of the most used method of this transformation. The final result shows that the methods which use a linear or multi-linear curve accept a error in their estimation. The value of mA is not important but the patient thickness is very important and it can introduce a error more than 10 percent in the final result.

International Nuclear Information System (INIS)

The purposes of this report are (1) to perform a Verification and Validation (V and V) test for the VIPEX(Vital-area Identification Package EXpert) software and (2) to improve a software quality through the V and V test. The VIPEX was developed in Korea Atomic Energy Research Institute (KAERI) for the Vital Area Identification (VAI) of nuclear power plants. The version of the VIPEX which was distributed is 3.2.0.0. The VIPEX was revised based on the first V and V test and the second V and V test was performed. We have performed the following tasks for the V and V test on Windows XP and VISTA operating systems: ? Testing basic functions including fault tree editing ? Testing all kind of functions ? Research for update from Visual BASIC 6.0 to Visual BASIC 2008

CERN Document Server

The Quantum Mechanics Conceptual Survey (QMCS) is a 12-question survey of students' conceptual understanding of quantum mechanics. It is intended to be used to measure the relative effectiveness of different instructional methods in modern physics courses. In this paper we describe the design and validation of the survey, a process that included observations of students, a review of previous literature and textbooks and syllabi, faculty and student interviews, and statistical analysis. We also discuss issues in the development of specific questions, which may be useful both for instructors who wish to use the QMCS in their classes and for researchers who wish to conduct further research of student understanding of quantum mechanics. The QMCS has been most thoroughly tested in, and is most appropriate for assessment of (as a posttest only), sophomore-level modern physics courses. We also describe testing with students in junior quantum courses and graduate quantum ...

Science.gov (United States)

We propose a quantum secure direct communication scheme based on non-orthogonal entangled pairs and local measurement. In this scheme, we use eight non-orthogonal entangled pairs to act as quantum channels. Due to the non-orthogonality of the quantum channels, the present protocol can availably prohibit from all kinds of valid eavesdropping and acquire a secure quantum channel. By local measurement, the sender acquires a secret random sequence. The process of encoding on the random sequence is identical to the one in one-time-pad. So the present protocol is secure. Even for a highly lossy channel, our scheme is also valid. The scheme is feasible with present-day techniques.

Energy Technology Data Exchange (ETDEWEB)

The validity is given to the newly proposed two weighting {delta}f scheme (Wang et al., Research Report of National Institute for Fusion Science NIFS-588, 1999) for collisional or neoclassical transport calculations, which can solve the drift kinetic equation taking account of effects of steep plasma gradients, large radial electric field, finite banana width, and the non-standard orbit topology near the axis. The marker density functions in weight equations are successively solved by using the idea of {delta}f method and a hierarchy of equations for weight and marker density functions is obtained. These hierarchy equations are solved by choosing an appropriate source function for each marker density. Thus the validity of the two weighting {delta}f scheme is mathematically proved. (author)

Energy Technology Data Exchange (ETDEWEB)

The dogmatic and constitutional basis as well as points of definition concerning the Technical Code Clean Air (TA Luft) are explained at first, followed by an assessment of the air pollution concentrations within the overall complex of the air pollution abatement measures, and an analyses of air pollution concentrations as a concretization of the state-of-the-art. In connection with the differentiation of the various applicability levels of TA Luft, the inhouse validy for authorities, the importance for law courts and, finally, the external binding effect for plant operators and possible third parties are discussed. At the center of attention are questions concerning validity claims and validity possibilities. (HSCH).

British Library Electronic Table of Contents (United Kingdom)

This study deals with the neutronics analysis of the current core configuration of a 3MW TRIGA Mark-II research reactor at Atomic Energy Research Establishment (AERE), Savar, Dhaka, Bangladesh and validation of the results by benchmarking with the experimental, operational and available Safety Analysis Report (SAR) values. The comprehensive neutronics code system SRAC was used to develop a versatile and accurate full-core model of the TRIGA core. The model represents in detail all components of the core with literally no physical approximation. All fresh fuel and control elements as well as the vicinity of the core were precisely described. Cross-section data library generated from JENDL-3.2 were used. The validation of the model against benchmark experimental results is presented. The SRA...

Energy Technology Data Exchange (ETDEWEB)

Monte Carlo neutron transport methods can be used to verify the applicability of point kinetics for safety analysis of nuclear reactors. KENO-NR was used to obtain the transfer function of the Advanced Neutron Source reactor and the time delay between the core power production and the external detectors, a parameter of interest to the safety systems design. The good agreement between the Monte Carlo generated transfer function and the point kinetics transfer function validates that the uncommon ANS geometry does not preclude the use of point kinetics in the frequency range that was investigated. Various features of the power spectral densities also demonstrated the applicability of point kinetics. The time delay was obtained from the cross-power spectral density (CPSD) and is {approximately}15 ms. These analyses show that frequency analysis can be used experimentally to investigate the validity of the use of point kinetics models in critical ...

British Library Electronic Table of Contents (United Kingdom)

Even if there have been efforts to validate remote-sensing-based energy balance models, which provide evapotranspiration (ET) maps over a large spatial scale, few studies have been conducted to validate their performance in Korea. In this study, surface energy balance fluxes including ET were estimated and inter-compared with two different models using the Landsat-5 Thematic Mapper (TM) image over a watershed scale in Korea. While there were larger spatial discrepancies for net radiation, soil heat and sensible heat fluxes on a pixel-by-pixel basis between the two models, relatively smaller spatial discrepancies for the latent heat flux and daily ET were detected. The spatial discrepancies for the daily ET were larger in low topography and dense vegetation ranges. Despite the different par...

Energy Technology Data Exchange (ETDEWEB)

In this paper, the moisture buffering capacity of spruce plywood is measured by recording the change in mass of a test specimen when the air relative humidity (RH) is changed between 33% RH and 75% RH. The aim is to represent diurnal cycles in indoor humidity with 33% RH maintained for 16 h and 75% RH maintained for 8 h. Measurements are taken using two different apparatuses, which provide different convective transfer coefficients between the air and the plywood, and the results are compared to a numerical model for validation. The validated numerical model is then used to investigate the effect of initial conditions, boundary conditions and thickness on the moisture buffering capacity of plywood. The results show that the buffering capacity of plywood depends on the initial conditions and thickness of the plywood as well as the surface film coefficient and humidity cycle. (author)

International Nuclear Information System (INIS)

The objective of this project is to develop multi-dimensional computational models in order to improve the operation of uranium electrorefiners currently used in pyroprocessing technology. These 2-D (US) and 3-D (ROK) mathematical models are based on the fundamental physical and chemical properties of the electrorefiner processes. The validated models by compiled and evaluated experimental data could provide better information for developing advanced electrorefiners for uranium recovery. The research results in this period are as follows: - Successfully assessed a common computational platform for the modeling work and identify spatial characterization requirements. - Successfully developed a 3-D electro-fluid dynamic electrorefiner model. - Successfully validated and benchmarked the two multi-dimensional models with compiled experimental data sets

British Library Electronic Table of Contents (United Kingdom)

Mechanobiological theories have been introduced to illustrate the interaction between biology and the local mechanical environment during bone healing. Although several theories have been proposed, a quantitative validation using histomorphometric data is still missing. In this study, in vivo histological data based on an ovine animal experiment was quantified and used to validate bone healing simulations focussing on the endochondral ossification process. The bone formation at different callus regions (periosteal and endosteal bone at the medial and lateral side) was analyzed from in vivo data and quantitatively compared with in silico results. A histomorphometric difference was found in medial and lateral hard callus formation 3 weeks after osteotomy. However, the same amount of new bone...

Energy Technology Data Exchange (ETDEWEB)

Bioremediation of land crude oil and lube oil spills is an effective and economical option. Other options include road spreading (where permitted), thermal desorption, and off-site disposal. The challenge for environment and operations managers is to select the best approach for each remediation site. Costs and liability for off-site disposal are ever increasing. Kerr-McGee`s extensive field research in eastern and western Texas provides the data to support bioremediation as a legitimate and valid option. Both practical and economical bioremediation as a legitimate and valid option. Both practical and economical, bioremediation also offers a lower risk of, for example, Superfund clean-up exposure than off-site disposal.

International Nuclear Information System (INIS)

The real parts of the optical model potentials for 104 MeV alpha-particle and 156 MeV "6Li ion scattering from "4"0,"4"8Ca are calculated in terms of folding model approaches. The validity of different procedures is tested by comparing the differential cross section predictions with experimental data measured with high angular accuracy. It is found that a refined folding potential accounting for density dependence of an effective nucleon-nucleon interaction is appropriate for alpha particle scattering without any parameter adjustment. However, for "6Li ion scattering renormalization of the depth of the real potentials is necessary. (orig.).

International Nuclear Information System (INIS)

Environmental Impact Assessment (EIA) must account for legally protected and endangered species. Uncertainties relating to the validity and sensitivity of EIA arise from predictions and valuation of effects on these species. This paper presents a validity and sensitivity analysis of a model (BIO-SAFE) for assessment of impacts of land use changes and physical reconstruction measures on legally protected and endangered river species. The assessment is based on links between species (higher plants, birds, mammals, reptiles and amphibians, butterflies and dragon- and damselflies) and ecotopes (landscape ecological units, e.g., river dune, soft wood alluvial forests), and on value assignment to protected and endangered species using different valuation criteria (i.e., EU Habitats and Birds directive, Conventions of Bern and Bonn and Red Lists). The validity of BIO-SAFE has been tested by comparing predicted effects of landscape ...

International Nuclear Information System (INIS)

We present a general procedure to construct the first law of thermodynamics on the apparent horizon and illustrate its validity by examining it in some extended gravity theories. Applying this procedure, we can describe the thermodynamics on the apparent horizon in Randall-Sundrum braneworld imbedded in a nontrivial bulk. We discuss the mass-like function which was used to link Friedmann equation to the first law of thermodynamics and obtain its special case which gives the generalized Misner-Sharp mass in Lovelock gravity.

Energy Technology Data Exchange (ETDEWEB)

Current European and the US experiences in waste management are reviewed in the perspective of sustainable development. This publication questions the validity of the current approach taken by the Germany at ``closing the loop`` based on the example of packaging and packaging waste. The product item focus of current German legislation is compared with Danish and US approaches that are based on an integrated policy which covers the whole of waste generation and handling and is not product/item oriented. 1 fig., 2 tabs.

Science.gov (United States)

This study examined preliminary psychometric properties of the Teaching Practices Observation Scale (TPOS), a newly developed observational taxonomy for assessing teacher behaviors during free play with young children. Behaviors of 42 child caregivers and junior kindergarten teachers were coded using a combination of time-sampling, event-sampling, and behavior ratings. Findings support the validity of observational coding scheme. (Author/KB)

Energy Technology Data Exchange (ETDEWEB)

With the aim of an experimental check on the validity of the theory of molecular recognition, the authors have carried out the chemical-enzymatic synthesis and cloning of the gene of human calcitonin and also of the genes of antisense polypeptides to human calcitonin and miniproinsulin. It has been shown that recombinant plasmids obtained on the basis of these synthetic genes are capable of ensuring the biosynthesis of the given polypeptides in E. coli cells as hybrid proteins with the IgG-binding domain of staphylococcal protein A.

Energy Technology Data Exchange (ETDEWEB)

Certification as applied to existing computer codes includes the verification and validation process, placing the code in configuration control, establishing user qualification standards and training requirements. All software intended for use in critical calculations must be certified. This report is intended to fulfill the requirements for the certification of the SHIELD, SHLDED, GEDIT, GENPRT, FIPROD, FPCALC, and PROCES modules of the SHIELD system built February, 1992, by W.S. Parks. These modules are used for burnup, cooling, separate, and edit calculations.

Energy Technology Data Exchange (ETDEWEB)

Performance predictions have been made for attached-sunspace types of passively solar heated buildings. The predictions are based on hour-by-hour computer simulations using computer models developed in the framework of PASOLE, the Los Alamos Scientific Laboratory (LASL) passive solar energy simulation program. The models have been validated by detailed comparison with actual hourly temperature measurements taken in attached-sunspace test rooms at LASL.

Science.gov (United States)

This paper presents results of solid-liquid phase change, driven by volumetric energy generation, in a vertical cylinder. We show excellent agreement between a quasi-static, approximate analytical solution valid for Stefan numbers less than one, and a computational model solved using the CFD code FLUENT®. A computational study also shows the effect that the volumetric energy generation has on both the mushy zone thickness and convection in the melt during phase change.

British Library Electronic Table of Contents (United Kingdom)

This comprehensive, critical review summarizes the use of nanoparticles in enhanced and amplified chemiluminescence detection, illustrated by different reaction strategies, electrogenerated chemiluminescence sensors, immunoassay or hybridization labels and electrogenerated chemiluminescence immunoassay or hybridization sensors. We discuss the analytical applications on the basis of validity, range and sensitivity, and draw some useful conclusions about the most sensitive approach in each type of application.

British Library Electronic Table of Contents (United Kingdom)

Abstract An analytical model is developed to predict transient discharge flow into a tunnel drilled at various speeds through a heterogeneous formation. This model relies on simplifying assumptions commonly enforced in hydrogeologic engineering, and combines the convolution and superposition principles to account for composite sections with arbitrary parametric contrasts. An application to the data monitored during the exploratory drilling of an Alpine tunnel confirms the validity of the approach.

Energy Technology Data Exchange (ETDEWEB)

The management procedure of a large PRISE (Primary-to-Secondary) leakage accident at Loviisa nuclear power plant taking into account the plant modifications which are expected to be realized during 1995-96 is described. The management procedure has been validated by performing thermal hydraulic analyses with the computer code RELAP5/MOD3 and the results from these analyses are also shortly discussed. (4 refs., 6 figs., 1 tab.).

International Nuclear Information System (INIS)

The European Research and Development Program on decay heat removal by natural convection for the European Fast Reactor (EFR) covers the calculational methods and the model experiments performed for code validation. The studies concentrate on important physical effects of the cooling modes within the primary system and the direct reactor cooling circuits and include fundamental tests as well as reactor experiments. (author)

Energy Technology Data Exchange (ETDEWEB)

The results of the development work to improve the horizontal steam generator modelling using the CATHARE code as well as the results of the steady-state and the steam-line break calculations are presented. Also the results of the steady-state calculations are compared to the measurements performed in operating VVER power plants. (9 refs., 6 figs., 2 tabs.).

Energy Technology Data Exchange (ETDEWEB)

The glacial deposits of the West Tensleep Basin in the Bighorn Mountains of Wyoming are mapped and a relative chromology established. The deposits are correlated with the regional model as defined in the Wind River Mountains. A statistical analysis is performed on the density and weathering characteristics of the surficial boulders to determine their validity as indicators of relative age. (ACR)

International Nuclear Information System (INIS)

The paper considered the vibration signals of rotating equipment as cyclo stationary signals through analyzing the features of this kind of signals. Based on the analytic method of cyclic spectrum density, the paper pointed out that the impact frequency could be extracted effectively with the help of scanning cyclic frequency domain. The validity of the method of cyclic spectrum density is proved by simulating signals and the method is applied to the diagnosis of rolling bearings. (authors)

International Nuclear Information System (INIS)

Two sets of analytical correlations describing transitions between two-phase flow regimes are reviewed and discussed. One, the T-D set, is based on mechanistic models; the other, the Weisman set, on experimental correlations. The T-D set is preferred for horizontal flow, whereas the Weisman set seems preferrable for vertical flow. A computer code (FLOP) based on the T-D theory is described and applied to validate the theory.

Energy Technology Data Exchange (ETDEWEB)

Considering the fact that more than 40% of all household wastes are organic wastes composting could be an excellent relief and complement to other waste disposal methods (e.g. combustion or direct landfills). Provided the right conditions household wastes could be composted together with sewage sludges and manures. The paper discusses the legal aspects, quantitative evaluations, conveying systems, as well as the compost utilization and marketing aspects valid for the Federal Republic of Germany.

British Library Electronic Table of Contents (United Kingdom)

This paper mainly considers the asymptotic stability of interval neutral delay-differential systems, which corrects a technical error in the proof given in [Applied Math. Letters, 16(2003) 1063-1068] by a linear fractional transformation of an interconnection matrix with structured real parametric uncertainties. In addition, a new condition, in terms of the structured singular value, is provided to ensure the stability of the interval system. Finally, an example is given to demonstrate the validity of our criteria.

CERN Document Server

A new estimator of the local density of dark energy is suggested which comes from the virial theorem for non-relativistic gravitating systems embedded in the uniform dark energy background.

UK PubMed Central (United Kingdom)

BackgroundProfessionalism is a critical quality for physicians to possess. Physician professionalism has received increased attention in recent years, with many authorities suggesting...Full Text Available

UK PubMed Central (United Kingdom)

Increasing evidence suggests that sex differences exist in the etiology, presentation, treatment, and outcome from stroke. The reasons for these sex disparities are becoming increasingly explored, but...Full Text Available

UK PubMed Central (United Kingdom)

Endogenous opioid peptides are substances involved in cell communication. They are present in various organs and tissues of the male and female reproductive tract, suggesting that they may regulate...Full Text Available

UK PubMed Central (United Kingdom)

BackgroundStatistical autoregressive analyses of direct and delayed density dependence are widespread in ecological research. The models suggest that changes in ecological factors...Full Text Available

UK PubMed Central (United Kingdom)

In this paper, we suggest that perception could be modeled by assuming that sensory input is generated by a hierarchy of attractors in a dynamic system. We describe a mathematical model which exploits...Full Text Available

UK PubMed Central (United Kingdom)

Monitoring describes the prospective supervision, observation, and testing of an ongoing process. The result of monitoring provides reassurance that the goal has been or will be achieved, or suggests...Full Text Available

UK PubMed Central (United Kingdom)

Many mutations associated with retinal degeneration lead to the production of misfolded proteins by cells of the retina. Emerging evidence suggests that these abnormal proteins cause cell death...Full Text Available

Science.gov (United States)

Nov 12, 2010 ... The adaptive, nonparametric matched filter algorithm suggested by Kay ... For the point design of a 4 sigma single event SNR the combined NR ...

UK PubMed Central (United Kingdom)

Three patients are described with foveal lesions resembling minute holes following trauma. The similarity of the lesions to foveomacular retinitis and solar retinopathy suggests that all these conditions...Full Text Available

UK PubMed Central (United Kingdom)

Epizootics of neoplasms in freshwater fish species are considered in relation to circumstantial and experimental evidence that suggest that some epizootics of neoplasia of hepatocellular, cholangiocellular,...Full Text Available

UK PubMed Central (United Kingdom)

Context: Some studies suggest altered pituitary functioning and TSH production with aging.Objective: Our objective was to test the hypothesis that less TSH production...Full Text Available

International Nuclear Information System (INIS)

Global angular momentum balance suggests that the neutron stars in Be/X-ray binaries are not spinning in equilibrium. This requires an X-ray lifetime ''approx <'' 10"5 yr, and suggests that there are many 'dead' Be/X-ray binaries in the Galaxy. Some of these may be turned up as millisecond radio pulsars with Be star companions. (author).

International Nuclear Information System (INIS)

Analytical expression of the dependence of freezing temperature of electrolyte (CdCl_2, CdSO_4, BeSO_4) aqueous solutions on their composition was found. Three different methods were suggested were suggested for calculation of water activity in multicomponent solution. It was established that sublinear extrapolation of freezing temperature of salt aqueous solutions was possible not up to -5 deg C, but up to -15 deg C, independently of their composition. 6 refs.; 2 figs.

Energy Technology Data Exchange (ETDEWEB)

This paper is concerned with the validation of the 3D deterministic neutral-particle transport theory code EVENT for shielding applications. The code is based on the finite element-spherical harmonics (FE-P{sub N}) method which has been extensively developed over the last decade. A general multi-group, anisotropic scattering formalism enables the code to address realistic steady state and time dependent, multi-dimensional coupled neutron/gamma radiation transport problems involving high scattering and deep penetration alike. The powerful geometrical flexibility and competitive computational effort makes the code an attractive tool for shielding applications. In recognition of this, EVENT is currently in the process of being adopted by the UK nuclear industry. The theory behind EVENT is described and its numerical implementation is outlined. Numerical results obtained by the code are compared with predictions of the Monte Carlo code MCBEND and also with the results ...

International Nuclear Information System (INIS)

The Accelerator Transmutation Waste System is under development at the Los Alamos National Laboratory. The goal is to perform an independent verification of the feasibility of actinide and long-lived fission product burning in this system. The authors' work is divided into five tasks: (a) production of an actinide and long-lived fission product cross section library from JEF 2.2; (b) simulation using MCNP and KENO IV Monte Carlo codes, of the Accelerator Transmutation Waste System configurations existing in literature; (c) validation of HETC Monte Carlo code (production of spallation source); (d) validation of the cross sections by comparison of Keff and reaction rate results, calculated with MNCP and KENO IV, with experimental benchmarks and intercomparison between the authors' calculations of a PWR unit cell and the computations carried out with various codes and cross section libraries (NEACRP critically group data); and (e) simulation of ...

International Nuclear Information System (INIS)

The 540 MWe PHWR has two fully independent shutdown systems. The first shutdown system (SDS-1) comprises of 28 spring assisted, vertical gravity drop shut-off rods, each consisting of a cadmium absorber sandwiched between stainless steel tubes. The second shutdown system (SDS-2) constitutes six poison tanks connected to respective zircaloy injection tubes. This system is capable of high speed injection of gadolinium nitrate solution (in D2O) into the moderator through these tubes. Theoretical estimation was carried out at different injection pressures and different concentration of gadolinium nitrate solution to arrive at the limiting value of these parameters from reactivity consideration point of view. The plant measurements of SDS-2 actuations at 60 and 80 Kg/cm2 pressure of helium was used to validate and upgrade the estimation model. The paper gives the details of the validation details of SDS-2 actuation. (author)

Energy Technology Data Exchange (ETDEWEB)

Essential to today's modern refineries and the gasoline production process are fluidized catalytic cracking units. By using a computational fluid dynamics (CFD) code developed at Argonne National Laboratory to simulate the riser, parametric and sensitivity studies were performed to determine the effect of catalyst inlet conditions on the riser hydrodynamics and on the product yields. Simulations were created on the basis of a general riser configuration and operating conditions. The results of this work are indications of riser operating conditions that will maximize specific product yields. The CFD code is a three-dimensional, multiphase, turbulent, reacting flow code with phenomenological models for particle-solid interactions, droplet evaporation, and chemical kinetics. The code has been validated against pressure, particle loading, and product yield measurements. After validation of the code, parametric studies were performed on ...

DEFF Research Database (Denmark)

There is increasing evidence that chemicals/test substances cannot only have adverse effects, but that there are many substances that can (also) have a beneficial effect on health. As this journal regularly publishes papers in this area and has every intention in continuing to do so in the near future, it has become essential that studies reported in this journal reflect an adequate level of scientific scrutiny. Therefore a set of essential characteristics of studies has been defined. These basic requirements are default properties rather than non-negotiables: deviations are possible and useful, provided they can be justified on scientific grounds. The 10 basic requirements for a scientific paper reporting antioxidant, antimutagenic or anticarcinogenic potential of test substances in in vitro experiments and animal studies in vivo concern the following areas: (1) Hypothesis-driven study design; (2) The nature of the test substance; (3) Valid and invalid test ...

Energy Technology Data Exchange (ETDEWEB)

A spectral element method embodying Large Eddy Simulation based on Re- Normalization Group theory for simulating Sub Grid Scale viscosity was chosen for this work. This method is embodied in a computer code called NEKTON. NEKTON solves the unsteady, 2D or 3D,incompressible Navier Stokes equations by a spectral element method. The code was later extended to include the variable density and multiple reactive species effects at low Mach numbers, and to compute transport of large particles governed by inertia. Transport of small particles is computed by treating them as trace species. Code computations were performed for a number of test conditions typical of flow past a deep tube bank in a boiler. Results indicate qualitatively correct behavior. Predictions of deposition rates and deposit shape evolution also show correct qualitative behavior. These simulations are the first attempts to compute flow field results at realistic flow Reynolds numbers of the order of 10{sup 4}. Code ...

Energy Technology Data Exchange (ETDEWEB)

Squeeze film dampers (SFD) are devices utilized to control vibrations of the shafts of high-speed rotating machinery. The SFD - squirrel cage combination is probably the most used system for tuning the stiffness and damping of the supports for rotors installed on ball bearings. Squeeze film dampers are essentially hydrodynamic bearings which contain the ball bearings housings of ball-bearings supported shafts. Consequently, the oil film within the SFD are influenced only by the precession and nutation of the shaft, that is the flow of the oil within the damper is not directly influenced by the spin of the rotor. However, in the classical theory, the flow in the thin film is also governed by the Reynolds equation. In this paper, some of the limits of the classical theory of the SFD are discussed and theoretical and experimental studies, which illustrate the ideas presented herein, are presented as well. The orbits of an unbalanced rotor that is supported by a ...

Science.gov (United States)

The GeoSAR (geographic synthetic aperture radar) program is a Defense Advanced Research Projects Agency (DARPA) sponsored program organized in cooperation with the Jet Propulsion Laboratory (JPL) and the California Department of Conservation. Some aspects of the program have been existent for almost two years. The technical goal of the program has been the development of rapid-mapping radar technologies, and has now, as its principal challenge, the development of a capability for terrain mapping under foliage. In this paper, we discuss validation of current technology and examine the utility of data products currently produced by the Environmental Research Institute of MIchigan's (ERIM) IFSARE, JPL's TOPSAR, and JPL's AIRSAR. We find that ERIM's X-band IFSARE system produces elevation maps to better than 2-m accuracy. Based on this we determine that TOPSAR elevation maps are accurate to at least 5 m. We also demonstrate the utility of JPL's AIRSAR's L-band radar ...

International Nuclear Information System (INIS)

The Melt Vessel Interaction (MVI) project is concerned with the consequences of the interactions that a core melt, generated during a postulated severe accident in a light water reactor, may have with the pressure vessel. In particular, the issues concerned with the failure of the vessel bottom head are the focus of the research. The specific objectives of the project are to obtain data and develop validated models, which could be applied to prototypic plants, and accident conditions, for resolution of issues related to the melt vessel interactions. The project work has been performed by nine partners having varied responsibility. The work included a large number of experiments, with simulant materials, whose observations and results are employed, respectively, to understand the physical mechanisms and to develop validated models. Applications to the prototypic geometry and conditions have also been performed. This report is volume 1 of the ...

Energy Technology Data Exchange (ETDEWEB)

The PERMCAT process chosen for the final clean-up stage of the Tokamak Exhaust Processing system of the ITER tritium plant combines in a single component a catalytic reactor and a permeator using Pd/Ag membranes. This study covers the mechanical behaviour of a Pd/Ag membrane under different operating conditions. The consequences of hydrogen uptake by the membrane during nominal operation but also during off-normal events are presented. Depending on the operating conditions, expansions around 2% and significant deformations are observed. Different mechanical designs of PERMCAT reactors are then discussed. The first generation comprises finger-type membranes and two new mechanical designs use either additional edge welded bellows or a special corrugated Pd/Ag membrane. These upgraded designs improve the robustness and simplify the geometry of the component. The experimental validation of these new units has been carried out based on the measurements of the processing ...

Energy Technology Data Exchange (ETDEWEB)

The thermal contact resistance between balls and inner and outer rings of thermally steady space-use deep groove ball bearings was studied experimentally to verify the validity of the previously proposed calculation method for the resistance. The 440C stainless steel single row bearing was used for measuring its steady state temperature distributions in a vacuum environment under axial, radial and combined load conditions. As a result, the experimental results of the resistance well agreed with calculated ones under each load condition resulting in the sufficient validity at nearly the same surface roughness. It was necessary to apply a static equivalent radial load to calculation under the combined load that a contact angle is larger than the angle of resultant force dependent on both load components. In experiments under only radial load, measurement of outer ring temperatures was necessary at some points with no contact with balls to avoid ...

Energy Technology Data Exchange (ETDEWEB)

As part of a larger elastic numerical modeling project, we have been investigating how energy reflected from steeply dipping interfaces is recorded using typical multicomponent acquisition geometries. Specifically, we have been interpreting how rcflection events from the flanks of salt dome structures are distributed on 3C and 4C phones for vertical seismic profiles (VSPs) and ocean bottom seismic (OBS) or land surface surveys. The ultimate goal of this investigation is to improve the structural imaging of steeply dipping interfaces and eventually to evaluate the usc of the recorded elastic wavefield for fluid description near these interfaces. In the current work, we focus on a common assumption used when processing converted wave reflection seismic data that most PP energy is recorded on the vertical geophone and/or the hydrophone and that most PS energy is recorded on the horizontal geophones. This is a useful assumption when it is valid, because it eliminates ...

International Nuclear Information System (INIS)

The thermal performance monitoring and optimization system TEMPO is developed at the OECD Halden Reactor Project. The system supports staff of nuclear power plants in identification and correction of problems, which cause small decreases in plant efficiency but which may lead to significant economical losses. The system-wide physical model consists of mathematical description of individual components, such as the reactor, the pumps, the heat exchangers, or the turbines, etc. TEMPO code has recently been extended with new steam generator (SG) models. The present paper summarizes the thermal-hydraulic modelling aspects of the vertical and the horizontal SG. The heat balance equations and their solution are shown with the appropriate initial and boundary conditions. The method of the calculation of the pressure losses are also introduced. The vertical SG model is based on a U-tube structure and treated as a 1D flow channel. The horizontal approach is a superposition of individually ...

International Nuclear Information System (INIS)

The SMART (System-integrated Modular Advanced ReacTor) which is a 330 MWt advanced integral PWR was developed by the KAERI (Korea Atomic Energy Institute) for electricity generation and seawater desalination. A thermal hydraulic evaluation and analysis of the SMART is performed by the TASS /SMR-S (Transient And Setpoint Simulation/System integrated Modular Reactor-Safety). The TASS/SMR-S code has various models reflecting the design features of the SMART such as the drift flux model, the core models (core power and core heat transfer model), the component models, and the specific models. One of the core models is the core heat transfer model. The role of this model is to calculate the heat flux and radial temperature profiles at a fuel rod surface using the relevant heat transfer correlations for all of the heat transfer modes. Also it is modeled to meet the requirements of the 10 CFR 50 appendix K EM model for the CHF (Critical Heat Flux) and post CHF conditions. In this paper, the ...

Energy Technology Data Exchange (ETDEWEB)

Some diagnostics at the National Ignition Facility (NIF), including the Gamma Reaction History (GRH) diagnostic, require multiple channels of data to achieve the required dynamic range. These channels need to be stitched together into a single time series, and they may have non-uniform and redundant time samples. We chose to apply the popular cubic smoothing spline technique to our stitching problem because we needed a general non-parametric method. We adapted one of the algorithms in the literature, by Hutchinson and deHoog, to our needs. The modified algorithm and the resulting code perform a cubic smoothing spline fit to multiple data channels with redundant time samples and missing data points. The data channels can have different, time-varying, zero-mean white noise characteristics. The method we employ automatically determines an optimal smoothing level by minimizing the Generalized Cross Validation (GCV) score. In order to automatically ...

International Nuclear Information System (INIS)

The authors discuss radioimmunoassays (RIAs) for eicosanoids widely used in the field of experimental, clinical and pharmacological research. The main drawback of RIAs is the possibility of low specificity. This was clearly demonstrated during the controversy on plasma levels of 6-keto-PGF_1 #alpha#, the stable hydrolysis product of PGI_2. When extensive purification including reverse phase high pressure liquid chromatography (rp-HPLC) was performed prior to the RIA for 6-keto-PGF_1 #alpha# the levels were at least one order of magnitude less than previously claimed, and did not support the so-called circulating hormone hypothesis.

International Nuclear Information System (INIS)

Two avowable quantum communication schemes are proposed. One is an avowable teleportation protocol based on the quantum cryptography. In this protocol one teleports a set of one-particle states based on the availability of an honest arbitrator, the keys and the Einstein-Podolsky-Rosen pairs shared by the communication parties and the arbitrator. The key point is that the fact of the teleportation can neither be disavowed by the sender nor be denied by the receiver. Another is an avowable quantum secure direct communication scheme. A one-way Hash function chosen by the communication parties helps the receiver to validate the truth of the information and to avoid disavowing for the sender.

Energy Technology Data Exchange (ETDEWEB)

Current projections of the response of the biosphere to global climatic change indicate as much as 50% to 90% spatial displacement of extratropical biomes. The mechanism of spatial shift could be dominated by either (1) competitive displacement of northern biomes by southern biomes, or (2) drought-induced dieback of areas susceptible to change. The current suite of global biosphere models cannot distinguish between these two processes, thus determining the need for a mechanistically based biome model. The model is in an early stage of development and will require several enhancements, including explicit simulation of potential evapotranspiration, extension to boreal and tropical biomes, a shift from steady-state to transient dynamics, and validation on other continents.

Energy Technology Data Exchange (ETDEWEB)

Snapping or grating scapula is a condition of the shoulder girdle in which the patient complains of pain and an audible snapping sound which may be associated with pain. We evaluated the diagnostic value of the computed tomography (CT) scans using the clinical diagnosis of a grating scapula as the gold standard. This retrospective study reports the sensitivity, specificity, likelihood ratio and receiver operator characteristic curve for the CT scans and the k value as a measure of the interobserver agreement. None of the parameters validated the examination. We therefore concluded that CT scans are inappropriate for differentiation between a grating scapula and a normally functioning shoulder except in cases where bony abnormalities are present. (orig.)

International Nuclear Information System (INIS)

As the cost of developing completely new computer codes becomes prohibitive, designers of nuclear facilities are turning to more cost-effective approaches for meeting increasingly strict regulatory requirements applied to safety-related analysis. For designing and licensing the MAPLE family of research reactors, Atomic Energy of Canada Ltd. (AECL) is employing the strategy of adapting major existing codes by linking them together within networks of custom-built interface software. This approach builds on the international investment in developing, maintaining, and verifying existing primary codes and focuses on the less onerous development of interface codes. The resultant code systems are then validated for the new applications of interest.

Energy Technology Data Exchange (ETDEWEB)

Enhanced recovery by chemical flooding using surfactant and/or polymers simultaneously implies the following: (1) a fundamental knowledge of the physical chemistry of micellar systems and interfaces; (2) the proper formulation of mathematic models handling the basic mechanisms of oil recovery; and (3) the use of field-scale pilot units to test the validity of the models and to acquire technical knowledge. Efforts have been made by the French in these directions, and the main results are described. Special attention is paid to the search for new products and the improvement of manufacturing processes. 10 references.

Science.gov (United States)

Seeking effective methods is one of the most important goals in machinery fault diagnosis. The effective methods for gear fault diagnosis have been successively developed in our Institute. This paper is a comprehensive treatise based on our research work of recent years. A mathematical model of vibration signals for defective gears is physically described. Five effective new methods for gear fault diagnosis, such as zoom complex envelope analysis, wideband demodulation technique, bispectrum analysis, correlative spectrum analysis, and maximum entropy spectrum analysis for phase modulated signals, are summarily presented. The listed illustrations prove sufficiently the validation of these methods.

Energy Technology Data Exchange (ETDEWEB)

The present paper is concerned with the prediction method for the motions and tensions of mooring lines on slack-moored floating oceanic architectural building in coastal zone. The motions and the tensions of mooring lines were estimated by the time domain numerical simulation in the present method. The present method includes the nonlinearity of mooring system, slow varying wave drift force. The authors performed a time domain numerical simulation for motions and the tensions of mooring lines on floating barge in two component waves. Also, the results obtained by numerical simulation were compared with the experimental results. The validity of the present method was confirmed.

Energy Technology Data Exchange (ETDEWEB)

It is both experimentally and theoretically demonstrated that ion flow velocity at an arbitrary angle with respect to the magnetic field can be measured with a directional Langmuir probe. Based on the symmetry argument, we show that the effect of magnetic field on directional probe current is exactly canceled in determining the ion flow velocity, and obtain the generalized relation between flow velocity and directional probe currents valid for any flowing direction. The absolute value of the flow velocity is determined by an in situ calibration method of the probe. The applicability limit of the present method to a strongly ion-magnetized plasma is experimentally examined. (author)

International Nuclear Information System (INIS)

Periosteal Ewing's sarcoma is an uncommon, but well documented origin of this malignant condition with radiography signs, different from intramedullary growing tumours. Imaging modalities like CT or MRI supply proof of macroscopically intact endosteal cortical surface and free medullary cavity in long bones affected by this periosteal type of malignancy. Definite confirmation is valid after a careful microscopic investigation of the resected specimen. The prognosis of this type of Ewing's sarcoma may be favourable than that of the central type. Early diagnosis and therapy are thus essential. A clinical survey of six observations is given. (orig.).

International Nuclear Information System (INIS)

The validation of the forecast model for early emergency response to nuclear accidents is evaluated by trace tests in atmosphere in Daya Bay nuclear power site. The simulation experiment of the Daya Bay nuclear power site shows that the particle spreading image and the time-integrated concentration distribution given by plume concentration prediction model can perform the variation of pathway of the pollutant transport, as well as the effects of topography on transport and diffusion of pollutants. The simulation of five trace tests in field shows that 59.1% of ratios between predicted results and observed results are within the range of 10, and 41% of ratios are within the range of 5 approximately. (authors)

Energy Technology Data Exchange (ETDEWEB)

Neutron spectra measured in the FFTF In-Reactor Thimble (IRT) by proton recoil proportional counters, proton recoil emulsions, and passive dosimeters have been evaluated and compared with each other and with three-dimensionl diffusion theory calculated spectra for the purpose of validating the passive dosimeter spectrum adjustment technique. The least squares data adjustment code, FERRET, was used to combine measured reaction rates, calculated spectra, and dosimeter cross sections, resulting in adjusted spectra and cross sections with uncertainties and correlations that properly account for uncertainties and correlations on the input parameters.

Energy Technology Data Exchange (ETDEWEB)

A detailed examination of the aging processes that may take place in solid-dielectric extruded-type high voltage transmission cables under dry conditions is presented. Particular emphasis is placed on the aging process as affected by the separate and simultaneous action of four main aging factors, namely the electrical, mechanical and thermal stresses, and the physical and chemical environment. A number of pertinent aging models are considered and their validity and applicability to accelerated aging tests on solid-type transmission cables are discussed.

Energy Technology Data Exchange (ETDEWEB)

A wood/polymer composite was produced by impregnating Ramin wood with methyl methacrylate monomer and subsequently polymerizing it by gamma irradiation. To assess the improvement in compression strength of the wood caused by the polymer impregnation, a microbuckling compression failure mechanism was used to model the compression failure of the composite. Such a mechanism was found to predict a linear relationship between the compression strength and the percentage polymer impregnation (by weight). Uniaxial compression test results at 45({plus minus}5)% and 90({plus minus}5)% relative humidity levels, after being statistically analysed, showed that such a linear relationship was valid for up to 100% polymer impregnation. (author).

Energy Technology Data Exchange (ETDEWEB)

Life management system is based on the valid nowadays in Estonian power plants regulation documentation. The system allows to estimate stress distribution in components, find computational assessment of cumulated creep damage, determine when and where it is necessary to cut off the particular number of microsamples or take replicas. Finally, the real metal condition may be assessed on the basis of metallographic specimen research and reasonable 3-R decision - run, repair, replacement - made on further component use. (orig.) 6 refs.

Energy Technology Data Exchange (ETDEWEB)

In the framework of the negotiations on the climatic changes, beginning at Rio in 1992, the France received an UN conference from the 4 to 15 of september 2000. This conference determined the necessary actions for the Kyoto protocol validation. This document presents in two part the program of these days. The first part is devoted to the world government policy and the second part defines the french actions decided to fight against the climatic change. A glossary of the main terms adapted to the climatic change domain, is also provided. (A.L.B.)

Science.gov (United States)

This study presents a theoretical analysis of heat generation and dissipation of field-controllable magneto-rheological fluid (MRF) shock absorbers. Since MRF dampers are energy- dissipating devices, the issues of heat generation and dissipation are important in predicting their performance. A theoretical model is developed based on Bingham plastic model to estimate temperature history of the MRF dampers. The governing equation includes the MRF viscosity as a function of the temperature. The numerical solutions are compared with experimental results in order to validate the accuracy of the model, and excellent agreements are obtained.

Energy Technology Data Exchange (ETDEWEB)

The present paper dealt with the extension of tendon friction coefficient correlation as a function of loading end load and circumferential angle, proposed in the former paper. The extended correlation further included the effects of the number of strands contacted with sheath, tendon diameter, politicization of tendon and tendon local curvature. The validity of the correlation was confirmed by several published measured data. The structural analysis of middle cylinder part of 1/4 PCCV (Prestressed Concrete Containment Vessel) model was conducted using the present friction coefficient correlation. The results were compared with the analysis using constant friction coefficient, focused on the tendon tension force distribution. (author)

DEFF Research Database (Denmark)

A simple closed-form equation to calculate the envelope correlation between any two receiver or transmitter antennas in a multi-input multi-output (MIMO) system of an arbitrary number of elements is derived. The equation uses the scattering parameters obtained at the antenna feed point to calculate the envelope correlation coefficient. This approach has the advantage that it does not require knowledge of the antenna radiation pattern. Numerical data that include conductor and permittivity loss are shown to validate the approach. Using the scattering parameters for calculating the envelope correlation is less laborious and relatively cheaper, as compared to the radiation pattern approach.

Energy Technology Data Exchange (ETDEWEB)

Neutron deficient nuclei with mass numbers A {approx} 90 and 40 {<=} Z {<=} 44 have been studied making use of the Osiris and Nordball spectrometers. The high spin states of these nuclei and their electromagnetic decay properties are compared to shell model calculations based on the core {sup 88}Sr and using different parametrizations of the residual interaction. The dependence of the mean square deviations of experimental and theoretical level energies, branching ratios, and transition probabilities on the neutron numbers N = 46-50 and the validity of seniority as a good quantum number are discussed. (orig.).

International Nuclear Information System (INIS)

Nonparabolicity of the heavy hole band in diamond-like semiconductors, which occurs within the framework of the three band model with the perturbation from the other bands taken into account according to the Loewdin procedure, is studied. A direct dependence of nonparabolicity on the band anisotropy (caused by the different effect of Gamma/sub 15c/ and Gamma/sub 12c/ bands) and the inverse dependence on the magnitude of the spin-orbit splittiing is established. A connection between the effective mass of heavy holes and their energy is obtained, which is valid for the majority of diamond-like semiconductors, except for materials with a very strong nonparabolicity of the band of silicon type.

British Library Electronic Table of Contents (United Kingdom)

We propose unsteady-state reverse osmosis cell modelling in two dimensions. The convection-diffusion equation describing the concentration of the relevant chemical species is solved by a finite difference technique, while the velocity field is described by empirical expressions for spiral-wound membrane cells. A non-constant permeability is introduced to take into account the effects of membrane compaction at high operating pressures. The role of concentration polarization is discussed for different values of the parameters describing the global process. Finally, the model is applied to predict the effects of a pulsating flow where a cyclic pressure feed is adopted to enhance the permeate flux. In this context, an experimental validation of the model is proposed.

International Nuclear Information System (INIS)

The three determination methods of alpha activity ration are described, namely geometric progression method, extrapolation method and curve fitting method. The validity of the geometric progression method is demonstrated in the present work. The "2"3"8Pu/("2"3"9Pu + "2"4"0Pu) evaluated by extrapolation method is compared with that by geometric progression method. Also, the "2"3"8Pu/("2"3"9Pu + "2"4"0Pu)evaluated by curve fitting method is compared with that by geometric progression.

Energy Technology Data Exchange (ETDEWEB)

It is possible to create nomographs similar to Fig. 2.10 to characterise damage potential of candidate time histories, provided there exists extensive records of earlier time-histories and the damage that they have caused. Thus in order to create such nomographs, one needs the correlated documentation between the input to the structure and the resulting damage. In order to use the Response-Spectra approach, one needs good statistical description of the input to the system. Extensive literature exists on both these methods. The MAC method that has being developed for the present research has yet to be validated. However, if it is successful, it would provide a valuable link between the SEA method and the rational method.

Energy Technology Data Exchange (ETDEWEB)

The validity is given to the newly proposed two {delta}f method for neoclassical transport calculation, which can be solve the drift kinetic equation considering effects of steep plasma gradients, large radial electric field, finite banana width, and an orbit topology near the axis. The new method is applied to the study of ion transport with steep plasma gradients. It is found that the ion thermal diffusivity decreases as the scale length of density gradient decreases, while the ion particle flux due to ion-ion self collisions increases with increasing gradient. (author)

Energy Technology Data Exchange (ETDEWEB)

Equipment Qualification technology for I and C system on nuclear grade have been approved with accurate and safe for verifying and validation. It contributes to acknowledge of reliability and to review of user approval. Also it did not completely satisfied the requirement of Russia, it can be satisfied by bit of modification on design. It is expected to support the export of safety PLC to nuclear power plant. Proven EQ technology is required on the further markets of nuclear. Therefore, comparison test with foreign country is necessary to support the mutual accreditation of EQ for export of domestic products.

Energy Technology Data Exchange (ETDEWEB)

An apparatus was designed and built for the purpose of exposing samples of solid polymers to varying temperatures, atmospheres and stress levels while quantitatively recording the resulting chemiluminescence. Preliminary data were acquired with this apparatus that show a correlation between an enhanced chemiluminescence signal at a low level of applied stress and a decrease in tensile strength for the most commonly used epoxy resin in high performance fiber composites, TGMDA DDS. The studies with cellular silicone cushions (which are used to accommodate thermal expansion and contraction) have defined the temperature regimes in which accelerated aging tests are valid for extrapolation to ambient temperature. Preliminary data on Kevlar fibers is also discussed.

International Nuclear Information System (INIS)

The objectives of this paper are to document the physicochemical and aquatic toxicological quality of a beneficial-use produced-water discharge and its effect on a receiving stream in Wyoming. Fish and water-flea survival, growth, and reproduction tests indicated that the discharge and all other sampling stations passed the state effluent biomonitoring acute toxicity testing endpoints. while benthic macroinvertebrates were absent at the discharge point designated by the Natl. Pollutant Discharge Elimination System (NPDES), productive and reproducing populations were present at all other downstream and mixing-zone stations. This investigation confirmed the validity of the beneficial-use subcategory for this oilfield discharge.

Energy Technology Data Exchange (ETDEWEB)

Longitudinal space charge (LSC) force can be a main effect driving the microbunching instability in the linac for an x-ray free-electron laser (FEL). In this paper, the LSC-induced beam modulation is studied using an integral equation approach that takes into account the transverse (radial) variation of LSC field for both the coasting beam limit and bunched beam. Changes of beam energy and the transverse beam size can be also incorporated. We discuss the validity of this approach and compare it with other analyses as well as numerical simulations.

International Nuclear Information System (INIS)

It is important to accurately estimate the effects of strong earthquake motions on the basemat uplift behavior and structural responses for the seismic design of nuclear power plant buildings. In this paper, an analysis model which describes the soil part using the 3 dimensional FEM was proposed to be used when the ground contact ratio is low, and the validity of this model was confirmed. Furthermore, investigations using the model were carried out where the attaching force under the basemat was taken into account, in order to more realistically estimate the basemat uplift behavior. The effects in the case of the building being embedded were also investigated.

Energy Technology Data Exchange (ETDEWEB)

Supplementing the collection of artificial neural network methodologies devised for monitoring energy producing installations, a general regression artificial neural network is proposed for the identification of the two-phase flow that occurs in the coolant channels of boiling water reactors. The utilization of a limited number of image features derived from radiography images affords the proposed approach with efficiency and non-invasiveness. Additionally, the application of counter-clustering to the input patterns prior to training accomplishes an 80% reduction in network size as well as in training and test time. Cross-validation tests confirm accurate on-line flow regime identification.

International Nuclear Information System (INIS)

Organizational risk indicators are proposed as a tool for risk control during operation of offshore installations, as a complement to QRA-based indicators. An organizational factor framework is developed based on a review of existing organizational factor frameworks, research on safety performance indicators, and previous work on QRA-based indicators. The results comprise a qualitative organizational model, proposed organizational risk indicators, and a quantification methodology for assessing the impact of the organization on risk. The risk indicators, when validated, will aid in a frequent control of the risk in the periods between the updating of the quantitative risk assessments.

British Library Electronic Table of Contents (United Kingdom)

Abstract Telecare has become an increasingly common medical service in recent years. However, new service must be close to the market and be market-driven to have a high likelihood of success. This article analyzes the business model of a telecardiology service managed by a general hospital. The methodology of the article is as follows: (1) initially it describes the elements of the service based on the ontology of the business model, (2) then it transfers these elements into the choices for business model dynamic loops and examines their validity, and (3) finally provides an empirical financial analysis of the service to assess the profit-making possibilities.

International Nuclear Information System (INIS)

AECL is undertaking the validation of ADDAM, an atmospheric dispersion and dose code based on the Canadian Standards Association model CSA N288.2. The key component of the validation program involves the comparison of air concentrations predicted by the model with measured values. Measurements are available from field studies at two Canadian reactor sites and from a wind tunnel study of the CANDU site at Wol song, Korea. The measurements were obtained close enough to the release points to test the model for exclusion area boundaries as small as 500 m. Model predictions were higher than the observations almost 75 percent of the time and the magnitude of the over predictions was typically much larger than the magnitude of the under predictions. The effect of the topography at the Wol song site was limited to small changes in plume trajectory due to channeling in valleys and a small reduction in the lateral spread of the plume. The terrain did not ...

Science.gov (United States)

Assessment of the immune system's capability to respond to antigens with the generation of specific antibodies, whilst under the influence of a test article, is required in toxicity tests according to the European guideline for repeated dose toxicity testing of medicinal products. The purpose of this study in rats was to validate methodology for the determination of Keyhole Limpet Haemocyanin (KLH)-specific antibodies under the influence of an immunologically active compound. The immunosuppressant FK506, commercially available as Prograf, was administered orally (gavage) to five rats per sex per group at dosages of 0.5mg/kg per day or 3mg/kg per day, for a period of 4 weeks. On days 14 and 22, KLH was administered subcutaneously, with an adjuvant (AluGel), to the two treated groups and a control (i.e. without FK506 treatment) approximately 1h following administration of FK506. Terminal investigations included haematology parameters, titration of KLH-specific ...

Energy Technology Data Exchange (ETDEWEB)

Field data for validating plume models were collected in and around the Bull Run Steam Plant during two four-week periods between July and October, 1982. The field measurements were the second phase of the Plume Model Validation and Development (PMV and D) program. The Bull Run Steam Plant is located near Oak Ridge, Tennessee, and the area is described as the ''Moderately Complex Site'' to distinguish it from the ''Plains Site'' in eastern Illinois, which was the scene of the first phase of the PMV and D study conducted in 1980-81. The measurement program consisted of a set of meteorological, source, aerometric, and tracer measurements to track and characterize the plume. The tracer measurements constituted the largest portion of the total effort, and it involved the release of SF/sub 6/ tracer gas from the stack, and the sampling and analysis of nearly 64,000 air samples ...

Energy Technology Data Exchange (ETDEWEB)

Automatic segmentation of anatomical structures in medical images is a valuable tool for efficient computer-aided radiotherapy and surgery planning and an enabling technology for dynamic adaptive radiotherapy. This paper presents the design, algorithms and validation of new software for the automatic segmentation of CT images used for radiotherapy treatment planning. A coarse to fine approach is followed that consists of presegmentation, anatomic orientation and structure segmentation. No user input or a priori information about the image content is required. In presegmentation, the body outline, the bones and lung equivalent tissue are detected. Anatomic orientation recognizes the patient's position, orientation and gender and creates an elastic mapping of the slice positions to a reference scale. Structure segmentation is divided into localization, outlining and refinement, performed by procedures with implicit anatomic knowledge using standard image ...

UK PubMed Central (United Kingdom)

Sunlight exposure has been suggested as a cause of AMD. To examine this, we collected detailed histories of ocular sun exposure in 838 watermen who work on the Chesapeake Bay. The presence and severity...Full Text Available

UK PubMed Central (United Kingdom)

Background:Several studies suggest transient ischemic attack (TIA) may be neuroprotective against ischemic stroke analogous to preinfarction angina's protection against...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

The temperature dependence of the dislocation mobility threshold is investigated on the basis of a dislocation model suggested by Frenkel-Kontorova. The critical value is obtained for the stress/temperature, corresponding to the dislocation depinning from its equilibrium position. The universal behaviour of a barrier height at finite stress and temperature is revealed and investigated.

UK PubMed Central (United Kingdom)

BackgroundResponse shift theory suggests that improvements in health lead patients to change their internal standards and re-assess former health states as worse than initially rated...Full Text Available

UK PubMed Central (United Kingdom)

It has been suggested for quality assurance purposes that linac output variations for helical tomotherapy (HT) be within ±2% of the long-term average. Due to cancellation of systematic...Full Text Available

UK PubMed Central (United Kingdom)

OBJECTIVESAlthough several studies suggest that slow gait speed is a predictor of falls, it may also be a protective mechanism to prevent falls. Further, fast walking...Full Text Available

UK PubMed Central (United Kingdom)

The C-C chemokine receptor 5, 32 base-pair deletion (CCR5-Δ32) allele confers strong resistance to infection by the AIDS virus HIV. Previous studies have suggested...Full Text Available

UK PubMed Central (United Kingdom)

Electrophysiological events are of central importance during the phagocyte respiratory burst, because NADPH oxidase is electrogenic and voltage sensitive. We investigated the recent suggestion that...Full Text Available

UK PubMed Central (United Kingdom)

Previous work has provided evidence that plants may require boron to maintain adequate levels of pyrimidine nucleotides, suggesting that the state of boron deficiency may actually be one of pyrimidine...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

Comparative studies of flocculent and grand-design spirals suggest that density waves are not the predominant trigger of star formation in most galaxies. Implications for chemical evolution are profound. It may be possible to ignore the details of the spiral-wave phenomenon in research aimed at unifying the chemical properties of spiral disks. 16 references.

UK PubMed Central (United Kingdom)

BackgroundPeroxiredoxins (Prxs) have recently been suggested to have a role in tumorigenesis.MethodsWe studied the expression of Prx I-VI and their...Full Text Available

UK PubMed Central (United Kingdom)

BackgroundRecent evidence suggests that some sex differences in brain and behavior might result from direct genetic effects, and not solely the result of the organizational effects...Full Text Available

UK PubMed Central (United Kingdom)

Accumulated lines of evidence suggest that hyperimmune responses to periodontal bacteria result in the destruction of periodontal connective tissue and alveolar bone. The etiological roles of periodontal...Full Text Available

UK PubMed Central (United Kingdom)

The anatomical basis for the concept of meridians in traditional Chinese medicine (TCM) has not been resolved. This paper reviews the evidence supporting a relationship between acupuncture points/meridians...Full Text Available

UK PubMed Central (United Kingdom)

A structurally conserved element, the trigger loop, has been suggested to play a key role in substrate selection and catalysis of RNA polymerase II (pol II) transcription elongation. Recently resolved...Full Text Available

UK PubMed Central (United Kingdom)

BackgroundAlthough some previous studies have suggested that posttraumatic growth (PTG) is comprised of several factors with different properties, few have examined both the association...Full Text Available

UK PubMed Central (United Kingdom)

Inferences concerning the lives of extinct animals are difficult to obtain from the fossil record. Here we present a novel approach to the study of extinct carnivores, using a comparison between fossil...Full Text Available

UK PubMed Central (United Kingdom)

The looming potential of deformable alignment tools to play an integral role in adaptive radiotherapy suggests a need for objective assessment of these complex algorithms. Previous studies in this area...Full Text Available

UK PubMed Central (United Kingdom)

Some laboratory experiments have suggested that power-frequency electric and magnetic fields (EMF) may be capable of influencing calcium efflux from cell membranes, pineal function, and circadian rhythms....Full Text Available

UK PubMed Central (United Kingdom)

SUMMARYTwo abundant classes of mobile elements, namely Alu and L1 elements, continue to generate new retrotransposon insertions in human genomes. Estimates suggest that these...Full Text Available

UK PubMed Central (United Kingdom)

BackgroundThere are no drugs presently available to treat traumatic brain injury (TBI). A variety of single drugs have failed clinical trials suggesting a role for drug combinations....Full Text Available

International Nuclear Information System (INIS)

Method for description of X-ray radiation dose distribution based on semiempirical description of dose fields is suggested. At that dose field description parameters can be easily individualized for concrete X-ray device.

UK PubMed Central (United Kingdom)

An influential neural model of face perception suggests that the posterior superior temporal sulcus (STS) is sensitive to those aspects of faces that produce transient visual changes, including facial...Full Text Available