UK PubMed Central (United Kingdom)

We have established a reliable method to induce invasive and non-invasive carcinomas in the heterotopically transplanted urinary bladder of rats by repeated injection of N-methyl-N-nitrosourea (MNU),...Full Text Available

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Supplementing the collection of artificial neural network methodologies devised for monitoring energy producing installations, a general regression artificial neural network is proposed for the identification of the two-phase flow that occurs in the coolant channels of boiling water reactors. The utilization of a limited number of image features derived from radiography images affords the proposed approach with efficiency and non-invasiveness. Additionally, the application of counter-clustering to the input patterns prior to training accomplishes an 80% reduction in network size as well as in training and test time. Cross-validation tests confirm accurate on-line flow regime identification.

UK PubMed Central (United Kingdom)

Cryptic invasions are a largely unrecognized type of biological invasion that lead to underestimation of the total numbers and impacts of invaders because of the difficulty in detecting them. The distribution...Full Text Available

International Nuclear Information System (INIS)

Positron emission tomography (PET) is the gold standard for non-invasive assessment of myocardial viability and allows accurate detection of coronary artery disease by assessment of myocardial perfusion. Magnetic resonance imaging (MRI) provides high resolution anatomical images that allow accurate evaluation of ventricular structure and function together with detection of myocardial infarction. Potential hybrid PET/MR tomography may potentially facilitate the combination of information from these imaging modalities in cardiology. Furthermore, the combination of anatomical MRI images with the high sensitivity of PET for detecting molecular targets may extent the application of these modalities to the characterization of atherosclerotic plaques and to the evaluation of angiogenetic or stem cell therapies, for example. This article reviews studies using MRI and PET in parallel to compare their performance in cardiac applications together with the potential benefits ...

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A crucial step in human breast cancer progression is the acquisition of invasiveness. There is a distinct lack of human cell culture models to study the transition from pre-invasive to invasive phenotype as it may occur 'spontaneously' in vivo. To delineate molecular alterations important for this transition, we isolated human breast epithelial cell lines that showed partial loss of tissue polarity in three-dimensional reconstituted-basement membrane cultures. These cells remained non-invasive; however, unlike their non-malignant counterparts, they exhibited a high propensity to acquire invasiveness through basement membrane in culture. The genomic aberrations and gene expression profiles of the cells in this model showed a high degree of similarity to primary breast tumor profiles. The xenograft tumors formed by the cell lines in three ...

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Tumour hypoxia represents a significant challenge to the curability of human tumours leading to treatment resistance and enhanced tumour progression. Tumour hypoxia can be detected by non-invasive and...Full Text Available

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Abstract Purpose: To compare the safety and efficiency of conventional monopolar, plasmakinetic and holmium laser transurethral resection of bladder tumor (CM-TURBT, PK-TURBT and HoL-TURBT) while managing primary non-muscle invasive bladder cancer. Patients and Methods: From 2005 to 2009, 173 patients with primary non-muscle invasive bladder cancer underwent endoscopic surgery. Among them, 51 patients underwent CM-TURBT, 58 patients underwent PK-TURBT, and 64 patients underwent HoL-TURBT. All patients were divided into three risk groups (low, intermediate, and high) based on the European Association of Urology guidelines and prognostic factors of recurrence. Clinical data, included preoperative, operative, and postoperative management and follow-up, were recorded. Results: Patient demograp...

UK PubMed Central (United Kingdom)

Five standard, non-invasive tests of cardiovascular, autonomic function were performed in each of four groups of 30 subjects: controls, group 1, diabetics without clinical evidence of neuropathy; group...Full Text Available

UK PubMed Central (United Kingdom)

BackgroundRetinitis pigmentosa (RP) is characterized by progressive night blindness, visual field loss, altered vascular permeability and loss of central vision. Currently there...Full Text Available

UK PubMed Central (United Kingdom)

IntroductionColorectal cancer (CRC) is the second leading cause of cancer-related deaths, but currently available non-invasive screening programs have achieved only...Full Text Available

UK PubMed Central (United Kingdom)

IntroductionA rare side effect of antipsychotic medication is neuroleptic malignant syndrome, mainly characterized by hyperthermia, altered mental state, haemodynamic dysregulation,...Full Text Available

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The association between invasive and native species varies across spatial scales and is affected by phylogenetic relatedness, but these issues have rarely been addressed in aquatic ecosystems. In this study, we used a non-native, highly invasive species of Poaceae (tropical signalgrass) to test the hypotheses that (i) tropical signalgrass success correlates negatively with success of most native species of macrophytes at fine spatial scales, but its success correlates positively or at random with natives at coarse spatial scales, and that (ii) tropical signalgrass is less associated with native species belonging to the family Poaceae than with species belonging to other families (Darwin?s naturalization hypothesis). We used a dataset obtained at fine (0.25?m2) and coarse (ca. 1,000?m2) sca...

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Background When assessing the function of the cardiovascular system, cardiac output (CO) is a substantial parameter. For its determination, numerous non-invasive techniques have been proposed in the recent years including inert gas rebreathing (IGR) and impedance cardiography (ICG). The aim of our study was to evaluate whether a novel ICG algorithm (electrical velocimetry) and IGR can be used interchangeably in the clinical setting. Methods A total of 120 consecutive stable patients were included resulting in two pairs of repeated non-invasive cardiac output measurements. Results The mean CO was 5.0???1.2?l/min (range 2.6?8.6?l/min) using IGR and 4.4???1.1?l/min (1.7?7.4?l/min) using ICG, respectively. Bland?Altman analysis revealed an acceptable agreement with a mean bias of 0.6???1.2?l/m...

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OBJECTIVE To present our initial experience of thulium laser resection via a flexible cystoscope for recurrent non-muscle-invasive bladder cancer (ThuRBT), as transurethral resection for bladder tumour (TURBT) is regarded as the reference standard for treating this disease, but alternative laser resection or ablation is suitable especially for recurrent tumours. PATIENTS AND METHODS From January 2005 to October 2005, 32 patients with early recurrent bladder tumour (recurrent within a year after TURBT) were treated with ThuRBT via a flexible cystoscope. The follow-up included urine analysis, ultrasonography and cystoscopy every 3 months. RESULTS All patients were treated successfully with ThuRBT in one session, with no bladder haemorrhage, obturator nerve reflex or vesicle perforation. Rand...

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Twenty-two out of 31 patients with chronic renal failure and secondary hyperparathyroidism who underwent parathyroidectomy before operation underwent non-invasive image diagnosis of parathyroid glands by computed tomography (CT), scintigraphy with /sup 201/TlCl and /sup 99m/TcO/sup 4 +/, and/or ultrasonography. CT visualized 39 of 45 parathyroid glands (86.7%), weighing more than 500 mg. Scintigraphy with a subtraction method using a computer performed the diagnosis in 19 of 27 glands (70.4%). Ultrasonography detected 21 of 27 glands (77.8%). Image diagnosis was also useful in the postoperative follow-up study. The non-invasive image diagnosis of parathyroid glands in patients with chronic renal failure is thus valuable for 1) definite diagnosis of secondary hyperparathyroidism, 2) localization, and 3) diagnosis for effectiveness of conservative treatment.

UK PubMed Central (United Kingdom)

AIM: To evaluate the biological and clinical characteristics of miR-622 in gastric cancer.METHODS: We analyzed the expression of miR-622 in 57 pair matched gastric neoplastic and adjacent non-neoplastic...Full Text Available

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The non-invasiveness of autofluorescence technology may reduce sampling error and time delay for histopathology diagnosis. We establish biophotonic methods and guidelines to visualize and interpret early epithelial tissue changes that signify disease. Flexible and rigid fiber endomicroscopy instrumentation design parameters feasible for translation towards clinical use are in development.

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A non-recursive model is proposed and empirically tested with data of opponents of nuclear power. In explaining conventional and unconventional participation the theory of collective action is applied and modified in two respects: the perceived influence on the elimination of collective evils are taken into account; the selective incentives considered are non-material ones. These modifications proved to be valid: the collective good variables and non-material incentives were important determinants for the two forms of participation. Another result was that there is a reciprocal causal relationship between conventional and unconventional participation.

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A non-invasive, wide-band electromagnetic (EM) impedance difference system for shallow subsurface electrical structure characterization in environmental and engineering problems has been developed at the Lawrence Berkeley National Laboratory (LBNL). Electrical parameters of interest are electrical conductivity and dielectric permittivity that are deduced from the impedance difference data. The prototype system includes a magnetic loop transmitter, which operates between 0.1 MHz and 100 MHz, an electrical dipole antenna for observing the electric field, and a loop antenna for measuring the magnetic field.All antennas are mounted on a cart made of non-metallic material for easy movement of the whole array for profiling. Surface EM impedance difference is obtained by taking the difference of the ratios of the electric fields to the magnetic fields at selected frequencies at two different levels. Numerical simulations will be presented to verify ...

UK PubMed Central (United Kingdom)

Minimally invasive parathyroidectomy is the procedure of choice for primary hyperparathyroidism due to parathyroid adenoma. Localization of the offending adenoma in minimally invasive parathyroidectomy...Full Text Available

International Nuclear Information System (INIS)

Post-mortem magnetic resonance (MR) imaging is of increasing interest not only as an alternative to autopsy but as a research tool to aid the interpretation and diagnosis of in utero MR images. The information from the post-mortem MR has allowed the development of imaging sequences applicable to in utero imaging and neonatal imaging. It has established brain development during gestation and has provided data on this to which in utero MR can be compared. The detail available from the post-mortem images is such that brain development can be studied in a non-invasive manner, a permanent record on the normal and abnormal areas is available and a greater understanding of developmental abnormalities is possible.

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This paper focuses on a theoretical model that predicts the temperature increase of Magneto-rheological (MR) fluid dampers experiencing a sinusoidal input motion. A theoretical model is developed to estimate the temperature rise based on the non-linear behavior of the MR fluid damper. This model is solved numerically, and the numerical solution is compared with a known linear solution and experimental result in order to validate the accuracy of the model. Also, a non-dimensional form of the governing equations are developed to examine the key parameters. The non-dimensional terms show the effect of external and internal parameters on the trends of heat dissipation as well as heat generation within the MR fluid damper.

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High-level expression of mitotic arrest defective protein 2 (MAD2), a central component of the spindle assembly checkpoint, has been observed in a variety of human malignancies. Aim of the present study was to observe the expression of MAD2 in human non-small-cell lung cancer (NSCLC) and explore its clinicopathologic significance and evaluate MAD2 expression as a prognostic marker. MAD2 transcript was found to be overexpressed in the great majority of lung cancers by semi-quantitative RT-PCR. A total of 358 NSCLCs were analyzed immunohistochemically on tissue microarrays. High-level MAD2 expression was observed in 26.3% (94 of 358 cases), and correlated with male sex (P=0.0002), tumor progression (pT status) (P=0.0009), visceral or parietal pleural invasion (P=0.0151), non-adenocarcinoma, ...

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A stable isotope mass-balance of dissolved inorganic carbon during a blue-green algae bloom in a softwater lake demonstrates that at low partial pressure of carbon dioxide there must be a large net negative carbon isotope fractionation between atmospheric CO/sub 2/ and the CO/sub 2/ absorbed by lake water at pH = 9.5. Chemical enhancement of CO/sub 2/ invasion at high pH by the reaction CO/sub 2/ + OH/sup -/ ..-->.. HCO/sub 3//sup -/ at large apparent film thicknesses may result in carbon isotope fractionation approaching that for a hydroxide solution. This phenomenon, coupled with a decrease in the photosynthetic fractionation, forced the surface water of a softwater lake to achieve increasingly negative delta /sup 13/C values during an algal bloom, which is in the opposite sense to the trend that results from photosynthesis under less extreme conditions. This and other similar systems must operate under non-equilibrium (kinetic) ...

UK PubMed Central (United Kingdom)

The origin of myofibroblasts or myofibroblastic cells in the desmoplastic stroma associated with carcinoma invasion has been controversial. In the early invasive area of a rectal adenocarcinoma reported...Full Text Available

UK PubMed Central (United Kingdom)

Invasive species pose serious threats to community structure and ecosystem function worldwide. The impacts of invasive species can be more pervasive than simple reduction of species numbers. By using...Full Text Available

British Library Electronic Table of Contents (United Kingdom)

The meiotic spindle in the oocyte is composed of microtubules and plays an important role during chromosome alignment and separation at meiosis. Polarized light microscopy (PLM) could be useful for a non-invasive evaluation of the meiotic spindle and may allow removal of nuclear structures without fluorochrome staining and ultraviolet exposure. In this study, PLM was used to assess its potential application in porcine reproductive technologies. The objectives of the present study were to assess the efficiency of PLM to detect microtubule-polymerized protein in in vitro-matured porcine oocytes; to examine its effects on the oocyte developmental competence; to select oocytes based on the presence of the meiotic spindle detected by PLM; and to assess the efficiency oocyte enucleation assisted...

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Purpose To evaluate disease failure patterns and overall survival (OS) of women with triple-negative (TN) breast cancer who underwent breast-conserving therapy (BCT) and to understand the relationship of TN tumors with other prognostic factors. Patients and Methods The Surveillance, Epidemiology, and End Results (SEER) registry identified 562 women diagnosed and/or treated with unilateral invasive breast cancer during 2003?2004 at three Emory hospitals. After medical record review, 193 eligible women, with all tumor types, received BCT. Primary endpoints (local, regional, and distant recurrences) and secondary endpoint (OS) were evaluated using chi-square tests and Cox proportional hazards models. Results Of the 193 women, 33 (17.1%) had TN tumors and 160 (82.9%) had non-TN tumors. Patient...

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Porous flow occurs in a wide range of materials and applies to many commercially relevant applications such as oil recovery, chemical reactors and contaminant transport in soils. Typically, breakthrough and pressure curves of column floods are used in the laboratory characterization of these materials. These characterization methods lack the detail to easily and unambiguously resolve flow mechanisms with similar effects at the core scale that can dominate at the aquifer or oil field scale, as well as the effects of geometry that control the flow at interfaces as in a perforated well or the inlet of an improperly designed column. Non-invasive imaging techniques such as MRI have been shown to provide a far more detailed characterization of the properties of the solid matrix and flow, but usu...

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Aim: This study was performed: 1) to assess the relationship between blood flow velocity in the internal carotid artery (CBFICA) and pial artery pulsation (cc-TQ) and 2) to evaluate flow-induced changes in pial artery compliance. Methods: Experiments were performed on 10 crossbred male rabbits. Heart rate (HR), blood pressure (BP), left ventricle ejection fraction (LVEF), CBFICA, the systolic-diastolic blood volume fraction in the brain circulation (CBFSDF) and cc-TQ were recorded after glucagon and acetazolamide administration. cc-TQ was measured with near-infrared transillumination back scattering sounding (NIR-T/BSS), LVEF and CBFSDF with gated scintigraphy and BP and CBFICA with electromagnetic pressure and flow transducers, respectively. Doses of drugs were chosen to exert a haemodyna...

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An apparatus for non-invasively inspecting an object, such as an item of luggage, for explosives material is described. It comprises a multi-channel thermal neutron inspection system having a plurality of neutron irradiation chambers. Simultaneous operation of several channels increases the maximum system throughput several times. Each chamber has a lithium neutron source which is stimulated to neutron production by a proton beam. Beam switching magnets are energised by pulsing to divert a common proton beam to each source in turn. The initial beam is generated by a radio frequency quadrupole accelerator. The advantages of this system are very low residual source activity and controllable neutron production thereby minimising safety hazards. The irradiation chamber may contain several different gamma ray detectors to identify the elements present in explosives material. In addition, a neutron radiography imaging means may be employed to identify the presence of ...

British Library Electronic Table of Contents (United Kingdom)

Purpose: The DBA/2J mice have been used as an animal model for human pigmentary glaucoma. However, these mice develop various degrees of disease symptoms at different ages, making it difficult to detect pathological changes of retinal degeneration at glaucoma onset. The purpose of this study is to develop a non-invasive assay to identify individual mice that develop visual deficits. Materials and Methods: We apply two behavioral tests, a swimming test of visual discrimination and a test of optomotor response, to identify glaucomatous DBA/2J mice. We then examine whether the elevation of intraocular pressure (IOP), the common risk factor for glaucoma, affects visual performances of the DBA/2J mice. We further compare the retinal ganglion cell death, one of the signature glaucoma symptoms, i...

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MRT is able to demonstrate arteries while MR angiography can quantify blood flow by a non-invasive method. In the present paper blood flow measurements were carried out in four selected cases on the basis of phase mapping. In 3 patients with lesions in the pelvis or thigh, angiography was performed in order to localise the stenosis or occlusion and this was followed by qantitative blood flow measurements. The results showed that angiography may not always provide all necessary information concerning a haemodynamically significant stenosis. The method may also be used for quantifying blood flow in the renal arteries and that it has significant advantages over the colour Doppler method. (orig.).

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of Concern; Parks; Management; Monitoring Exotic and Invasive Species Northern Arizona University. Canyons, Cultures, and Environmental Change. Species of Concern; Contacts;...

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The validity is given to the newly proposed two weighting {delta}f scheme (Wang et al., Research Report of National Institute for Fusion Science NIFS-588, 1999) for collisional or neoclassical transport calculations, which can solve the drift kinetic equation taking account of effects of steep plasma gradients, large radial electric field, finite banana width, and the non-standard orbit topology near the axis. The marker density functions in weight equations are successively solved by using the idea of {delta}f method and a hierarchy of equations for weight and marker density functions is obtained. These hierarchy equations are solved by choosing an appropriate source function for each marker density. Thus the validity of the two weighting {delta}f scheme is mathematically proved. (author)

International Nuclear Information System (INIS)

The authors have been involved for the last few years in developing high affinity sigma-receptor-specific radiopharmaceuticals for use in nuclear medicine. They recently demonstrated that sigma-1 receptors are expressed in human melanoma cells and that sigma receptors could be used as external markers for non-invasive imaging. In order to determine the presence of sigma receptors in other human tumors they have screened numerous non-small cell lung carcinoma, melanoma and breast cancer cell lines. All of these cell lines expressed high sigma receptor densities using commercially available ["3H]-(+)-pentazocine or ["3H]DTG tritiated sigma ligands. Therefore, a sigma ligand with high affinity in both sigma-1 and sigma-2 subtype pharmacological assays could be potentially useful for imaging a variety of primary and metastatic sites of various origins. The authors describe recent efforts to develop high affinity sigma radiopharmaceuticals and ...

British Library Electronic Table of Contents (United Kingdom)

Genome-wide association studies have linked lung cancer risk with a region of chromosome 15q25.1 containing CHRNA3, CHRNA5 and CHRNB4 encoding a3, a5 and b4 subunits of nicotinic acetylcholine receptors (nAChR), respectively. One of the strongest associations was observed for a non-silent single-nucleotide polymorphism at codon 398 in CHRNA5. Here, we have used pharmacological (antagonists) or genetic (RNA interference) interventions to modulate the activity of CHRNA5 in non-transformed bronchial cells and in lung cancer cell lines. In both cell types, silencing CHRNA5 or inhibiting receptors containing nAChR a5 with a-conotoxin MII exerted a nicotine-like effect, with increased motility and invasiveness in vitro and increasing calcium influx. The effects on motility were enhanced by addit...

International Nuclear Information System (INIS)

Intracapsular femoral neck fractures remain unsolved fractures even after improvement in techniques of diagnosis and internal fixation. Individuals who sustain displaced femoral neck fractures are at high risk of developing avascular necrosis and non-union. Although several methods for predicting the viability of femoral head have been reported, they are not effective or widely used because of unreliability, potential complications and technical difficulties. Dynamic MRI was introduced in the recent past as a simple, non-invasive technique to predict the femoral head viability after the femoral neck fractures. In this study role of dynamic MRI was studied in 30 patients with 31 intracapsular femoral neck fractures. Fractures were divided in to three types according to dynamic curve patterns on MRI evaluation and were followed up for 6 months to 2 years to observe the final outcome. Sensitivity, Specificity and the Accuracy of dynamic MRI in ...

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The E1 and E3 transition operators in the sdf-IBA model are discussed. An effective E1 operator containing one- and two-body terms explains very well the E1 data in transitional and rotational nuclei. The E1 parameters for rotational nuclei are obtained by imposing a constraint on the IBA model namely, the validity of Alaga rules for ``pure K`` states. The systematic behavior of the octupole strength is well reproduced using a one-body octupole operator. The anomalously large fragmentation of the low-energy octupole strength in non-rotational nuclei is shown to be a signature of the O(6) dynamical symmetry.

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This paper deals with the experimental identification and the validation of a non-parametric probabilistic approach allowing model uncertainties and data uncertainties to be taken into account in the numerical model developed to predict low- and medium-frequency dynamics of structures. The analysis is performed for a composite sandwich panel representing a complex dynamical system which is sufficiently simple to be completely described and which exhibits, not only data uncertainties, but above all model uncertainties. The dynamical identification is experimentally performed for eight panels. The experimental frequency response functions are used to identify the non-parametric probabilistic approach of model uncertainties. The prediction of the low- and medium-frequency dynamical responses obtained with the stochastic system is compared with the experimental measurements.

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In this work, a powerful analytical method, called He's parameter-expanding methods (HPEM) is used to obtain the exact solutions of non-linear modified Van der Pol's oscillator. The classical Van der Pol equation with delayed feedback and a modified equation where a delayed term provides the damping are considered. It is shown that one term in series expansions is sufficient to obtain a highly accurate solution, which is valid for the whole solution domain. Comparison of the obtained solution with those obtained using perturbation method shows that this method is effective and convenient to solve this problem. This method introduces a capable tool to solve this kind of non-linear problems.

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The aim of this work is to be able to describe transformations, occurring when solids and gases are in non isothermal and non isobaric conditions, with kinetic models. A methodology has been used. Two essential processes have to be taken into account: the germination and the growth. The germs are supposed to be formed (at constant temperature and pressure) in the grains surface with a constant velocity by surface unit, (gamma), called germination surface frequency (number of germs.m{sup -2}.s{sup -1}. The growth velocity is characterized by a growth surface reactivity, (phi) (in mol.m{sup -2}.s{sup -1}). With an appropriate transformation model, it is possible to obtain the variations of (gamma) and (phi) in terms of the temperature and pressure which are then used in the calculation of the velocity in non isothermal and non isobaric conditions. In order to validate the developed ...

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MRI provides a non-invasive diagnostic tool complementing echocardiography on one hand, and showing advantages over echocardiography, on the other hand, especially after corrective procedures. The multiple different MRI sequences need to be adapted to examinations of children and patients with congenital heart disease (CHD), and can be used to detect morphologic changes, blood-flow in the heart and thoracic vessels and diastolic or systolic function of myocardium. Several factors determine the success of the examination of a complex congenital heart disease or a postoperative situs. Pediatric radiologists and radiologists experienced in congenital heart diseases have to work in close cooperation. Echocardiography should be performed before MRI. The results of prior examinations and the clinical history of the patients, including possible palliative or reconstructive operations, must be available before MRI to guide the planning of the examination. With a systematic ...

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A scintimetric study using Tc-99m MDP was made of 54 patients with delayed union, nonunion, or late segmental collapse of the femoral head, 4-92 months after femoral neck fracture. In radiographically verified collapse, the radionuclide uptake ratio between the femoral head on the fractured and on the intact side (HHR) was significantly higher than in fractures resulting in delayed union or nonunion. On the basis of scintimetric and radiographic findings, the patients with healing disturbances could be divided into three groups, characterized by the following features: (1) Satisfactory post-reduction position of the fracture without subsequent redisplacement and a high HHR, which as a rule turned out to be delayed union; (2) The same radiographic pattern but with a lower HHR, which in most cases resulted in nonunion; (3) Inadequate reduction or early redisplacement of the fracture with a high HHR, which resulted in nonunion. The fractional precision in discriminating between different ...

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Non-invasive methods are described for estimating local cerebal blood flows (LCBF) and local partition coefficients (Llambda) during inhalation of 30 % stable xenon gas (Xe) in oxygen during CT scanning. After the denitrogenation with pure oxygen breathing, 30 % Xe is inhaled for four minutes to minimize subanesthetic effects with a rubber facemask and the delivery system of Xe. Local time-..delta.. Hounsfield units curve during the Xe wash-in and wash-out phase is utilized in order to calculate Llambda and LCBF using a least squares curve fitting analysis. Calculated Llambda and LCBF with the new method manifested reasonable distribution between the grey and white matters, and reproducibility was excellent in our study. Several case studies of patients with cerebral infarction are presented to demonstrate the characterization of Llambda and LCBF patterns in various tissues and theoretical grounds underlying the new method of curve fitting analysis are discussed.

International Nuclear Information System (INIS)

In the case of injuries of the ankle joint, an imaging technique is expected to reveal the state of the bones, ligaments, and articular cartilage. Irrespective of novel imaging techniques, a plain radiography will be made in order to obtain a first picture of the injury. Examples are given, showing that further orientation along the Lauge-Hansen classification scheme of this type of injury helps to completely ascertain the damage to the Articulatio talocruralis. Further examinations applying specific methods such as arthrography will detect possible, isolated syndesmosis ruptures; lesions of the ligaments can also be directly detected by CT or MRT. The articular cartilage and its lesions can be visualized by a combination of CT and arthrography, but are better shown by the completely non-invasive MRT. This latter method also gives insight into pathological processes with the bone. It allows to detect necrotic bone regions and their re-vitalisation in patients with ...

International Nuclear Information System (INIS)

Efficient and precise ablation of soft tissue is needed for non-invasive dermatological and corneal surgeries. Previous research has revealed that smooth and efficient cutting of certain soft tissues and gelatin is possible using a Free Electron Laser (FEL) with a wavelength of #lambda#=6.45 #mu#m, tuned to the amide-II band of protein. Gelatin ablation experiments have been carried out using a mid-infrared FEL within the waveband #lambda#=5.6-6.7 #mu#m by changing the primary absorbers such as water (#lambda#=6.1 #mu#m) and protein (#lambda#=6.45 #mu#m). The gelatin with 80 wt% water was efficiently ablated by FEL irradiation with the waveband #lambda#=#approx#5.95-6.19 #mu#m. On the other hand, using irradiation within #lambda#=#approx#6.4-6.6 #mu#m, many small bubbles were observed in the irradiated volume, and the gelatin was not ablated but significantly melted. Thus, it was found that the most effective wavelength was #approx#6.1 #mu#m, not #approx#6.45 ...

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To determine MTRs for normal structures and benign diseases in the breast two-dimensional magnetization transfer imaging was performed in 62 patients and in 3 young female volunteers. With regard to the MTRs of measurements in the normal breast tissues, fat tissues which is close to simple cysts in MTRs show little transfer of longitudinal magnetization. MTRs of the muscles was 15.15{+-}6.22%, which exceeded those of breast parenchyma. The breast parenchyma didn`t show the change of MTR value due to the difference of patient age and due to variable amount of fat and fibrous tissues. Breast parenchyma in the two young volunteers clearly showed biphasic change of MTR values in accordance with the menstrual cycle; little transfer value was due to hydration in the postovulatory period and high transfer value was due to dehydration in the preovulatory period. In the remaining one volunteer during lactation period, mammary parenchyma shows sever decrease in MTR, because mammary gland is ...

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Modern imaging technologies visualize different aspects of disease in a non-invasive way. Considerable progress has been made in the fusion of images from different imaging modalities using software approaches. One goal of fusion software is to align anatomical and functional images and allow improved spatial localization of abnormalities. The resulting correlation of the anatomical and functional images may clarify the nature of the abnormality and help diagnose or stage the underlying disease. Whereas successful image fusion software has been developed for the brain, only limited success has been achieved for image alignment in other parts of the body. The development and current status of alternative approaches are presented. Dual-modality imaging is described with devices where two modalities are combined and mounted in a single gantry. The use of existing scanner technology ensures that no compromises are made in the clinical efficacy of either the anatomical ...

International Nuclear Information System (INIS)

Cardiac disease research relies increasingly on small animal models and non-invasive imaging methods such as positron emission tomography (PET) and magnetic resonance imaging (MRI). Delayed enhancement magnetic resonance imaging (DE-MRI) using gadolinium-based contrast agents appear to be a visualizing infracted myocardium with high spatial resolution. Polar map (or bull's-eye image) was used to determination of the myocardial infarction area. Polar map is a comprehensive interpretation of the left ventricle. The infarct size was computed as the fraction of the total polar map areas. The threshold was computed as the percentage of mean intensity of the normal region. In other study, 50% predefined threshold value in varying range (30?70%) was most commonly use. However, predefined threshold value isn't acceptance in all case. The purpose of this study was to investigate methodological approach for automatic measurement of rat myocardial infarct size using PET and ...

UK PubMed Central (United Kingdom)

BackgroundEsophageal squamous cell carcinoma (ESCC) is one of the most aggressive carcinomas of the gastrointestinal tract. We assessed the relevance of Slug in measuring the invasive...Full Text Available

UK PubMed Central (United Kingdom)

By the time of primary 21st century, water hyacinth had become a serious environmental problem in China. Water hyacinth contributes to the major part of ecological hazards from the invasion of foreign...Full Text Available

UK PubMed Central (United Kingdom)

Merozoite surface proteins have been implicated in the initial attachment to the host red blood cell membrane that begins the process of invasion, an important step in the life cycle of the malaria...Full Text Available

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... ever get in this slide. This is basically mechanical properties of the polyuretha urethane polymer called Bioflex versus ...

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Invasive Aspergillosis

DEFF Research Database (Denmark)

The sources of non-white noise in Blood Oxygenation Level Dependent (BOLD) functional magnetic resonance imaging (fMRI) are many. Familiar sources include low-frequency drift due to hardware imperfections, oscillatory noise due to respiration and cardiac pulsation and residual movement artefacts not accounted for by rigid body registration. These contributions give rise to temporal autocorrelation in the residuals of the fMRI signal and invalidate the statistical analysis as the errors are no longer independent. The low-frequency drift is often removed by high-pass filtering, and other effects are typically modelled as an autoregressive (AR) process. In this paper, we propose an alternative approach: Nuisance Variable Regression (NVR). By inclusion of confounding effects in a general linear model (GLM), we first confirm that the spatial distribution of the various fMRI noise sources is similar to what has already been described in the literature. Subsequently, we ...

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The Savannah River Site (SRS) has a variety of waste units that may be temporarily or permanently stabilized by closure using an impermeable cover to prevent groundwater infiltration. The placement of an engineered kaolin clay layer over a waste unit is an accepted and economical technique for providing an impermeable cover but the long term stability and integrity of the clay in non-arid conditions is unknown. A simulated kaolin cap has been constructed at the SRA adjacent to the Burial Ground Complex. The cap is designed to evaluate the effects of desiccation on clay integrity, therefore half of the cap is covered with native soil to prevent drying, while the remainder of the cap is exposed. Measurements of the continuing impermeability of a clay cap are difficult because intrusive techniques may locally compromise the structure. Point measurements made to evaluate clay integrity, such as those from grid sampling or coring and made through a soil cover, may miss ...

DEFF Research Database (Denmark)

There is increasing evidence that chemicals/test substances cannot only have adverse effects, but that there are many substances that can (also) have a beneficial effect on health. As this journal regularly publishes papers in this area and has every intention in continuing to do so in the near future, it has become essential that studies reported in this journal reflect an adequate level of scientific scrutiny. Therefore a set of essential characteristics of studies has been defined. These basic requirements are default properties rather than non-negotiables: deviations are possible and useful, provided they can be justified on scientific grounds. The 10 basic requirements for a scientific paper reporting antioxidant, antimutagenic or anticarcinogenic potential of test substances in in vitro experiments and animal studies in vivo concern the following areas: (1) Hypothesis-driven study design; (2) The nature of the test substance; (3) Valid ...

British Library Electronic Table of Contents (United Kingdom)

The evolution of clinal variation has become a topic widely studied for invasive species. Most studies of this kind have found significant correlations between latitude and various plant traits, usually using univariate analytic methods. However, plants are composed of multiple, interacting traits, and it is this correlation among traits that can affect how quickly or even whether the populations of invasive plants adapt to their local climatic conditions. We used data from a common garden experiment to determine the possible formation of latitudinal clines in invasive North American populations of Lythrum salicaria L. (purple loosestrife) from the central portion of its invasive range. Analyses were conducted using the more common univariate approach (nested and oneway ANOVAs; linear regr...

British Library Electronic Table of Contents (United Kingdom)

The growing epidemic of juvenile obesity has prompted pediatricians to investigate obesity-related conditions in obese teenagers. We report a clinical case of severe hepatic fibrosis in an adolescent with severe and recent obesity. Because of elevated serum aminotransferase levels, abnormal hepatic ultrasonography and insulin resistance (impaired glucose tolerance), we suspected nonalcoholic steatohepatitis (NASH). Disease activity and fibrosis were confirmed on liver biopsy. Considering the risk of progression toward cirrhosis and its complications, and the pathological liver lesions, we started long-term medical monitoring and drug therapy to control weight loss. At present, although biopsy is the only validated way to establish the diagnosis of NASH, there is no consensus on its indicat...

British Library Electronic Table of Contents (United Kingdom)

A multivariate logistic regression model, based upon National Automotive Sampling System Crashworthiness Data System (NASS-CDS) data for calendar years 1999-2008, was developed to predict the probability that a crash-involved vehicle will contain one or more occupants with serious or incapacitating injuries. These vehicles were defined as containing at least one occupant coded with an Injury Severity Score (ISS) of greater than or equal to 15, in planar, non-rollover crash events involving Model Year 2000 and newer cars, light trucks, and vans. The target injury outcome measure was developed by the Centers for Disease Control and Prevention (CDC)-led National Expert Panel on Field Triage in their recent revision of the Field Triage Decision Scheme (American College of Surgeons, 2006). The ...

CERN Document Server

We obtain an elegant and useful description of the dynamics of Szekeres dust models (in their full generality) by means of "quasi--local" scalar variables constructed by suitable integral distributions that can be interpreted as weighed proper volume averages of the local covariant scalars. In terms of these variables, the field equations and basic physical and geometric quantities are formally identical to their corresponding expressions in the spherically symmetric LTB dust models. Since we can map every Szekeres model to a unique LTB model, rigorous results valid for the latter models can be readily generalized to a non--spherical Szekeres geometry. The new variables lead naturally to an initial value formulation in which all scalars are expressed as scaling laws in terms of their values at an arbitrary initial space slice. These variables also yield a significant simplification of numerical work, since the fluid flow evolution equations ...

Energy Technology Data Exchange (ETDEWEB)

During their life, intervertebral discs undergo degenerative changes which need not necessarily become lesions. Conventional X-rays do not provide information on the condition of the intervertebral discs, so MRT or CT are recommended as primary techniques as they are non-invasive. Invasive methods like myelography and especially discography should not be used unless a case is highly problematic. In infants with pains in the back, MRT should be carried out as early as possible as there is nearly always an organic cause. (orig.) [German] Die Bandscheibe ist im Laufe des Lebens degenerativen Veraenderungen unterworfen, die klinisch zu Beschwerden fuehren koennen, aber nicht fuehren muessen. Konventionlle Roentgenaufnahmen lassen zwar die Hoehenminderung des Bandscheibenfachs und begleitende knoecherne Veraenderungen erkennen, nicht aber den Zustand der Bandscheibe selbst. Die Beurteilung der Bandscheibe und des Knochens gelingt mit der CT, die ...

Energy Technology Data Exchange (ETDEWEB)

The purpose of the workshop was to determine the status of the field, to define instrumental and computational requirements, and to establish minimum specifications required by possible users. The most important message sent by implementers was the remainder that CMT is a tool. It solves a wide spectrum of scientific problems and is complementary to other microscopy techniques, with certain important advantages that the other methods do not have. High-resolution CMT can be used non-invasively and non-destructively to study a variety of hierarchical three-dimensional microstructures, which in turn control body function. X-ray computed microtomography can also be used at the frontiers of physics, in the study of granular systems, for example. With high-resolution CMT, for example, three-dimensional pore geometries and topologies of soils and rocks can be obtained readily and implemented directly in transport models. In turn, these geometries can ...

CERN Document Server

We improve the steady-state ab initio laser theory (SALT) of Tureci et al. by expressing its fundamental self-consistent equation in a basis set of threshold constant flux states that contains the exact threshold lasing mode. For cavities with non-uniform index and/or non-uniform gain, the new basis set allows the steady-state lasing properties to be computed with much greater efficiency. This formulation of the SALT can be solved in the single-pole approximation, which gives the intensities and thresholds, including the effects of nonlinear hole-burning interactions to all orders, with negligible computational effort. The approximation yields a number of analytic predictions, including a "gain-clamping" transition at which strong modal interactions suppress all higher modes. We show that the single-pole approximation agrees well with exact SALT calculations, particularly for high-Q cavities. Within this range of validity, ...

Energy Technology Data Exchange (ETDEWEB)

A mathematical model was developed to predict the penetration of a transient fuel spray, the temporal and spatial distribution of air-fuel mixture before the end of ignition delay and the subsequent pressure rise during combustion in a Direct-Injection Diesel Engine with and without swirl. The model accounts for the non-isothermal and non-isobaric character of processes during fuel injection resulting from continuous motion of the piston. The effects of various engine operating variables on spray were studied and graphically presented. The calculated spray penetration with and without crossflow of air is compared with the available experimental data of other researchers with good agreement. The model can predict the rate of combustible-mixture formation, the rate of heat release and cylinder pressure as a function of time in direct injection (DI) diesel engine. A single-cylinder D.I. research diesel engine was operated with N-hexadecane as the ...

International Nuclear Information System (INIS)

As researchers explore new applications for positron emission tomography radiopharmaceuticals, the demand for effective and readily available radiopharmaceuticals continues to increase. The syntheses of two such radiopharmaceuticals, ["1"1C]acetate and ["1"1C]palmitate, can be automated on the GE Tracerlab FX_C_-_P_r_o by utilizing Grignard reactions. Radiochemical purities of the ["1"1C]acetate and the ["1"1C]palmitate products were high (>98% and >99.9%, respectively) with average non-corrected yields of 18% (n=3) and 10% (n=5), respectively. These data comprise the validation trials for site qualification of clinical production of both radiopharmaceuticals. -- Graphical abstract: Automated syntheses of ["1"1C]acetate and ["1"1C]palmitate using a modified GE Tracerlab FX_C_-_P_r_o are reported. Radiochemical purities of the ["1"1C]acetate and the ["1"1C]palmitate products were high (>98% and >99.9%, respectively) with average ...

Science.gov (United States)

The epidermal compartment is complex and organized into several strata composed of keratinocytes (KCs), including basal, spinous, granular, and cornified layers. The continuous process of self-renewal and barrier formation is dependent on a homeostatic balance achieved amongst KCs involving proliferation, differentiation, and cell death. To determine genes responsible for initiating and maintaining a cornified epidermis, organotypic cultures comprised entirely of stratified KCs creating epidermal equivalents (EE) were raised from a submerged state to an air/liquid (A/L) interface. Compared to the array profile of submerged cultures containing KCs predominantly in a proliferative (relatively undifferentiated) state, EEs raised to an A/L interface displayed a remarkably consistent and distinct profile of mRNAs. Cultures lifted to an A/L interface triggered the induction of gene groups that regulate proliferation, differentiation, and cell death. Next, differentially expressed microRNAs ...

British Library Electronic Table of Contents (United Kingdom)

Invasive weeds have threatened the integrity of ecosystems throughout the world. They affect not only the species diversity of native areas but also their biological integrity. In India, a number of invasive exotic weeds have been reported but some viz. Parthenium hysterophorus, Lantana camara and Ageratum conyzoides, especially those from tropical America are troublesome and have caused adverse ecological, economic and social impact. These weeds can be seen growing in different landscapes but are luxuriantly localized in unattended forests and cultivated areas. Parthenium hysterophorus (Asteraceae, commonly known as congress grass) is perhaps the most troublesome and noxious weed of urban and rural India. Besides rapidly colonizing areas replacing the native vegetation, it is also known t...

British Library Electronic Table of Contents (United Kingdom)

The known metazoa parasite fauna of the invasive round goby Apollonia melanostoma (formerly Neogobius melanostomus) consists of 12 species. The core of the parasite fauna comprises two species: Cryptocotyle concavum and Diplostomum spathaceum; secondary species are absent; satellite species include Cercariae gen. sp. and Ergasilus sieboldi; rare species are Acanthocephalus lucii, Anguillicola crassus, Bothriocephalus sp., Dichelyne minutus, Hysterothylacium aduncum, Pomphorhynchus laevis, Piscicola geometra, and Tylodelphys clavata. Fifty percent of metazoa parasites that occurred in the invasive round goby in the Gulf of Gda?sk (an invasion that was first detected in 1990) are also typically found in the native Gulf of Gda?sk gobiids. The round goby hosts common fish parasite species: C. ...

British Library Electronic Table of Contents (United Kingdom)

Mapping the distribution of invasive alien plant species is significant for testing ecological hypotheses and for guiding effective management. Little is known about the distribution of invasive plants at landscape scale, and the factors controlling their dispersal and establishment are still poorly understood. This is the case for Rosa rugosa, an invasive shrub with negative effects on biodiversity in dune ecosystems of NW Europe. The aim of the study was to identify the factors which determine the distribution of R. rugosa in coastal dunes. In a large semi-natural dune area of NW Denmark (2364ha) all patches of the species (1321, 1.3-59.1m2) were GPS mapped. Patch distribution was GIS analysed, based on aerial photographs and vegetation maps. The distance of R. rugosa from the most consp...

UK PubMed Central (United Kingdom)

BackgroundWhereas there is increasing evidence that loss of expression and/or function of the thyroid hormone receptors (TRs) could result in a selective advantage for tumor development,...Full Text Available

UK PubMed Central (United Kingdom)

Background:Since first reported in 1996, endoscopic minimally invasive surgery of the cervical region has been shown to be safe and effective in the treatment of benign thyroid and...Full Text Available

UK PubMed Central (United Kingdom)

We compared the incidence of nasopharyngeal colonization by Streptococcus pneumoniae, the serotypes causing mucosal and invasive diseases, and the antibiotic resistance of these strains...Full Text Available

UK PubMed Central (United Kingdom)

BACKGROUNDOpen carpal tunnel release (OCTR) is the standard procedure for the surgical treatment of carpal tunnel syndrome. With the advent of minimally invasive surgery, endoscopic...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

This report documents the results of a project funded by DoD's Strategic Environmental Research and Development Program (SERDP) on the science behind development of predictive models for soot emission from gas turbine engines. Measurements of soot formation were performed in laminar flat premixed flames and turbulent non-premixed jet flames at 1 atm pressure and in turbulent liquid spray flames under representative conditions for takeoff in a gas turbine engine. The laminar flames and open jet flames used both ethylene and a prevaporized JP-8 surrogate fuel composed of n-dodecane and m-xylene. The pressurized turbulent jet flame measurements used the JP-8 surrogate fuel and compared its combustion and sooting characteristics to a world-average JP-8 fuel sample. The pressurized jet flame measurements demonstrated that the surrogate was representative of JP-8, with a somewhat higher tendency to soot formation. The premixed flame measurements revealed that ...

Energy Technology Data Exchange (ETDEWEB)

Nuclear medicine and magnetic resonance imaging (MRI) are widely used in cardiac diagnostics. Both techniques have been carefully evaluated and are equivalent for the assessment of regional and global wall motion as well as the evaluation of ejection fraction and cardiac volumes, though MRI is herein currently seen as gold standard. For evaluation of myocardial perfusion, extensive data exist for nuclear imaging, that, next to high diagnostic accuracy for evaluation of coronary artery disease, show incremental prognostic information and allow for independent risk stratification. Because of rapid technical advance, myocardial perfusion imaging has also become feasible with cardiac MRI. Results of recent studies are promising, but the data are few compared to perfusion scintigraphy. For viability assessment in patients with ischemic cardiomyopathy, positron emission tomography (PET) with FDG is currently seen as gold standard. However, single photon emission computed tomography (SPECT) ...

Energy Technology Data Exchange (ETDEWEB)

The objective of this study was to compare contrast-enhanced magnetic resonance angiography (CE MRA) and multislice computed tomographic angiography (MS CTA) in the follow-up of thoracic stent-graft placement. The CE MRA and MS CTA were performed following nitinol stent-graft treatment due to thoracic aneurysm (n=4), intramural bleeding (n=2) and type-B aortic dissection (n=5). Corresponding evaluation of arterial-phase imaging characteristics focused on the stent-graft morphology and leakage assessment. Stent-graft and aneurysm extensions were comparable between both techniques. Complete exclusion (aneurysm, n=4; dissection, n=2) was assessed with high confidence with CE MRA and MS CTA. Incomplete exclusion (intramural bleeding, n=2; dissection, n=3) was assigned to lower confidence scores on CE MRA compared with MS CTA. On CE MRA the stent-graft lumen demonstrated an inhomogeneous signal, the stent struts could not be assessed. The CE MRA can be used as alternative ...

International Nuclear Information System (INIS)

The purpose of this study is to evaluate the radiologic findings of the extraosseous Ewing's sarcoma. Six patients with pathologically confirmed extraosseous Ewing's sarcoma were retrospectively reviewed. Patients included two men and four women with an average age of 21.5 years (age range 9-48 years). Plain radiographs (six patients), magnetic resonance (MR) images (five patients), computed tomographic (CT) scans (three patients) and whole body scintigraphy (two patients) were reviewed and analyzed. Images were evaluated with regard to lesion location, size, margin, muscle or bone involvement and intrinsic imaging characteristics on CT and MRI. The tumors were located in the thigh (three patients), back (two patients) and upper arm (one patient). The tumors ranged in size from 2.3 cm to 7.5 cm (mean, 5.2 cm), were mainly well circumscribed and showed no evidence of calcification prior to treatment. Margins were well defined in four out of the six patients. Four patients had ...

International Nuclear Information System (INIS)

Magnetic resonance (MR) imaging was performed in 26 patients with Ewing's sarcoma of bone preceding and following neoadjuvant chemotherapy, to assess tumour response non-invasively prior to surgery. T1- and T2-weighted spin echo images were obtained. Changes including intra- and extramedullary signal intensities, tumour demarcation, tumour volume and the appearance of residual extramedullary tumour were compared with histophathology of the resected specimens. Reduction of tumour volume was significantly higher in good responders. Other single parameters did not correlated with histologic tumour response. However, when several MR parameters summarized in a classification system were combined, a positive correlation with histopathologic response was found. A limited decrease of tumour volume (<25 %) and/or residual soft tissue mass following chemotherapy correlated with a poor response. An inhomogeneous, well-defined cuff of abnormal tissue encircling the bone ...

Energy Technology Data Exchange (ETDEWEB)

Objective: Solid pseudopapillary tumor of the pancreas (SPTP tumor) is a rare pancreatic neoplasm with low malignant potential, which usually affects female patients in the second or third decades of life. It is a non-functional, slow-growing neoplasm that very often reaches considerable size before the first symptoms appear. Symptomatology is frequently related to tumor size. Surgical excision is usually curative in most cases. Infrequently the tumor can appear in male patients or in aged women, which can make the diagnosis more difficult. Some patients develop liver metastases in the follow-up that can be resected. Our purpose is to review the radiological and pathological findings of SPTP with emphasis on these infrequent cases. Subjects and methods: The medical records and radiological findings of patients who underwent surgery for SPTP between 2000 and 2005 were retrospectively reviewed. Study eligibility required that patients had undergone surgical resection ...

DEFF Research Database (Denmark)

Purpose To investigate the sensitivity and accuracy of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) for restaging the mediastinum after induction chemotherapy in patients with non-small-cell lung cancer (NSCLC). Patients and Methods One hundred twenty-four consecutive patients with tissue-proven stage IIIA-N2 disease who were treated with induction chemotherapy and who had undergone mediastinal restaging by EBUS-TBNA were reviewed. On the basis of computed tomography, 58 patients were classified as having stable disease and 66 were judged to have had a partial response. All patients subsequently underwent thoracotomy with attempted curative resection and a lymph node dissection regardless of EBUS-TBNA findings. Results Persistent nodal metastases were detected by using EBUS-TBNA in 89 patients (72%). Of the 35 patients in whom no metastases were assessed by EBUS-TBNA, 28 were found to have residual stage IIIA-N2 disease at ...

Energy Technology Data Exchange (ETDEWEB)

Bowel infarction is a rare and typical condition of the elderly; despite improvements in diagnostic imaging and vascular surgery, bowel infarction remains a major cause of acute abdomen, with mortality rates ranging 70-80%. Diagnosis on often late because clinical signs, laboratory data and radiologic findings are a specific. The authors investigated radiographic and particular CT patterns of intestinal infraction in 56 patients submitted to surgery within 12 hours of admission. We also report the CT findings of 5 of these patients who had reversible mesenteric ischemia. CT is more sensitive than radiography and does not exhibit the limitations of angiography (i.e., invasiveness, radiation exposure and complex organization). Therefore CT can presently be considered the method of choice in patients with suspected bowel infarction. [Italian] L'infarto intestinale rappresenta una malattia rara e tipica del soggeto anziano; nonostante il notevole ...

Energy Technology Data Exchange (ETDEWEB)

The security of ports and transportation is of utmost importance for the development of economy and the security of a nation. Among the necessary actions to ensure the security of ports and borders, the inspection of containers is one of the most time consuming and expensive procedures. Potential threats are the illegal traffic of radioactive materials that could be employed for the construction of weapons, as uranium and plutonium. New techniques for the inspections of containers should be fast, allow the detection and identification of dangerous materials, and be non-invasive, to reduce costs and delays. We propose to build a large surface photon and neutron detector based on plastic scintillator to identify the presence of fissile or fertile material inside a container. The detector consists of scintillator bars, wrapped in thin foils of reflecting material containing gadolinium for neutron capture and arranged in planes separated by few-millimeter-thick lead ...

Energy Technology Data Exchange (ETDEWEB)

A central problem in diagnostic radiology is to compare a new X-ray picture with a previous picture and from this comparison be able to decide if anatomical changes have occurred in the patient or not. It is of primary interest that these pictures are identical in projection. If not it is difficult to decide with confidence if differences between the pictures are due to anatomical changes or differences in their projection geometry. In this thesis we present a non invasive method that makes it possible to find the relative changes in the projection geometry between the exposure of a previous picture and a new picture. The method presented is based on the projection slice theorem (central section theorem). Instead of an elaborate search for a single new picture a pre-planned set of pictures are exposed from a circular orbit above the patient. By using 3D Fourier transform techniques we are able to synthesize a new X-ray picture from this set of ...

Science.gov (United States)

... VALIDATING NETWORK SECURITY POLICIES VIA STATIC ANALYSIS OF ROUTER ACL CONFIGURATION by Eric Gregory Wen Wei Wong ...

Science.gov (United States)

The MISR instrument aboard NASA's Terra satellite participated in the UAE-2 campaign, August-October 2004. This campaign represented a unique opportunity to study the complex aerosol situation in the Arabian Gulf region, in the context of a first-rate collection of aircraft and surface-based instruments, giving us the opportunity to do some groundbreaking satellite aerosol validation work. We aimed (1) to validate MISR aerosol retrieval results for dust and pollution particles over dark and light surfaces, and (2) to contribute regional maps of aerosol optical thickness (AOT) and particle micro-physical properties, giving spatial context to the field-instrument measurements, and moving toward a satellite-based regional aerosol climatology. The validation effort benefited from the combination of an instrumented aircraft and a regional network of surface-based sun photometers. We obtained high-quality sub-orbital data ...

Energy Technology Data Exchange (ETDEWEB)

We intend to solve equations governing turbulent plane-vertical isotherm and non isotherm jets by taking into account inflow conditions at the exit of the nozzle. The analysis is focused on the influence of these conditions on this type of flow. Two cases are considered (uniform and parabolic velocity and temperature profiles). A finite difference scheme is developed to solve the governing equations. This numeric model allows us to show that the region of fully developed regime begins much nearer the nozzle for the turbulent case than for the laminar flow case. Indeed, the turbulence increases the mixing between the incoming gas from the nozzle and the ambient fluid, and consequently the size of the potential core zone decreases. The results are compared to other works introducing mathematical variables based on the energy conservation for the case of the mixed convection and the momentum conservation for the forced convection, which allows the ...

Energy Technology Data Exchange (ETDEWEB)

In the paper, a fuzzy decision-making methodology is presented to decide the generation schedule of long-term hydrothermal problems with explicit recognition of statistical uncertainties in system production cost data, NO{sub x} emission data, system load demand and hydro reservoir water inflows. In deciding the optimal operation, three objectives operating cost, NO{sub x} emission and unsatisfied load demand over the whole of the planning period are simultaneously minimised. Specific technique is put forth to convert the stochastic models into their deterministic equivalents. The weighted minimax method is used to simulate the tradeoff relation between the conflicting objectives in the non-inferior domain. The fuzzy set theory is exploited to choose the best operating point over the tradeoff curve. An efficient decomposition technique is applied to reduce the complexity of the problem. In each subproblem, thermal generations are obtained by using simplified method ...

International Nuclear Information System (INIS)

Advanced modality of high-precision radiotherapy fulfilled by a composition of large numbers of small field beams called 'beamlets' can be achieved via nonuniform intensity fluencies. In case of radiation measurements and calculations with narrow high-energy photon beams, however, an accurate two-dimensional dosimetry is a challenging task due to dosimetrically unfavorable phenomena such as dramatic changes of the dose at the field boundaries, dis-equilibrium of the electrons resulting from larger detector volume, and non-uniformity between the detector and the phantom materials. Meanwhile, with the advantages of high spatial resolution and wide range of absorbed doses, there is a growing demand of GAFCHROMICat..EBT film to confirm delivered dose distribution. Especially, the effects from the material differences between the phantom and the film can be minimized in the heterogeneous condition since the GAFCHROMICat..EBT film is composed of tissueequivalent ...

Science.gov (United States)

To illustrate the implementation of a bottom-up approach to the study of culture in health disparities, this article describes the development of a cultural cancer screening scale (CCSS) using mixed methodologies. The aim was to identify cultural factors relevant to breast and cervical cancer screening, develop an instrument to assess them and examine its preliminary psychometric properties among Latin American (Latino) and non-Latino White (Anglo) women in Southern California. Seventy-eight Latino and Anglo women participated in semi-structured interviews, which were content coded based on Triandis' methods for the analysis of subjective culture. Based on the emerging cultural elements, items relevant to cancer screening were developed and pilot tested with 161 participants. After the instrument was refined, 314 Latino and Anglo women from various socioeconomic backgrounds completed the CCSS and data were factor analyzed resulting in five cultural factors: cancer ...

KoreaScience (Korea)

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British Library Electronic Table of Contents (United Kingdom)

Roads function as prime habitats and corridors for invasive plant species. Yet despite the diversity of road types, there is little research on the influence of these types on the spread of invaders. Common ragweed (Ambrosia artemisiifolia), a plant producing large amounts of allergenic pollen, was selected as a species model for examining the impact of road type on the spread of invasive plants. We examined this relationship in an agricultural region of Quebec, Canada. We mapped plant distribution along different road types, and constructed a model of species presence. Common ragweed was found in almost all sampling sites located along regional (97%) and local paved (81%) roads. However, verges of unpaved local roads were rarely (13%) colonized by the plant. A model (53% of variance expla...

British Library Electronic Table of Contents (United Kingdom)

The management programs for invasive species have been proposed and implemented in many regions of the world. However, practitioners and scientists have not reached a consensus on how to control them yet. One reason is the presence of various uncertainties associated with the management. To give some guidance on this issue, we characterize the optimal strategy by developing a dynamic model of invasive species management under uncertainties. In particular, focusing on (i) growth uncertainty and (ii) measurement uncertainty, we identify how these uncertainties affect optimal strategies and value functions. Our results suggest that a rise in growth uncertainty causes the optimal strategy to involve more restrained removals and the corresponding value function to shift up. Furthermore, we also...

British Library Electronic Table of Contents (United Kingdom)

Often ecologists and natural resource managers can easily access data on invasive species occurrence across a region. Yet, collecting species abundance data over a large area is arguably more important for decision making, but inherently costly, so methods which can provide robust information at low-cost are particularly valuable. Studies of species distribution often use occurrence data to build models of the environmental niche. Environmental suitability derived from such models may be used to predict the potential distributions of species. The ability of such models to predict spatial patterns in abundance have recently been demonstrated. Here we tested the relationship of environmental suitability with local abundance of an aquatic invasive species, olive hymenachne (Hymenachne amplexi...

International Nuclear Information System (INIS)

Full text: A Large Sample Neutron Activation Analysis (LSNAA) facility is under development at GRR-1 research reactor, NCSR 'Demokritos'. The LSNAA facility design incorporates sample irradiation in the reactor's graphite thermal neutron column and subsequent measurement of the activity induced at a gamma spectroscopy system with gamma ray transmission measurement options included. Monte Carlo neutron and photon transport code MCNP-4C was used to model the facility. Appropriate correction factors accounting for neutron field perturbation during sample irradiation, high purity germanium detector efficiency for the volume source and gamma ray self-absorption within the sample itself were derived. The results of the computations were experimentally verified by activation foil measurements for a set of known materials and a range of sample sizes extending up to 10 litters. Moreover, the special issue of large sample analysis of non-homogeneous samples is examined and ...

International Nuclear Information System (INIS)

In the present paper we estimate the effect of sodium in the in-service inspection of non-magnetic steam generators tubes using eddy current technique and eddy current probes based on a differential double bobbin coil configuration. Experimental measurements of defects signals in steam generator tubes of fast breeder reactor are compared with simulations results of a two-dimensional axisymmetric finite element code to validate a reliable electromagnetic model of the system (eddy current coils, steam generator tube, defect) when there is no sodium on the outer steam generator tube surface. The electromagnetic code is used to evaluate the sodium band and sodium layer signals when a defect is located under steam generator support plate. Using a multi-frequency algorithm, its parameters are determined in the 'no sodium condition' (there is no sodium on the outer steam generator tube surface), defects signal is enhanced during eddy currents ...

UK PubMed Central (United Kingdom)

OmpU porins are increasingly recognized as key determinants of pathogenic host Vibrio interactions. Although mechanisms remain incompletely understood, various species, including the...Full Text Available

UK PubMed Central (United Kingdom)

PurposeTo date there remains no effective therapy for metastatic melanoma and at the molecular level disease progression remains poorly understood. Recent work by...Full Text Available

UK PubMed Central (United Kingdom)

Syndecan-2, a transmembrane heparan sulfate proteoglycan, is a critical mediator in the tumorigenesis of colon carcinoma cells. We explored the function of syndecan-2 in melanoma, one of the most invasive...Full Text Available

UK PubMed Central (United Kingdom)

BackgroundThe common liver fluke Fasciola hepatica is the agent of a zoonosis with significant economic consequences in livestock production worldwide, and increasing...Full Text Available

Science.gov (United States)

PMID:18640506

UK PubMed Central (United Kingdom)

Zaprionus indianus was first recorded in Brazil in 1999 and rapidly spread throughout the country. We have obtained data on esterase loci polymorphisms (Est2 and Est3), and analyzed...Full Text Available

UK PubMed Central (United Kingdom)

Cervical cancer is known to metastasize primarily by the lymphatic system. Dissemination through lymphatic vessels represents an early step in regional tumor progression, and the presence of lymphatic...Full Text Available

CERN Document Server

'Trojan horses', 'logic bombs', 'armoured viruses' and 'cryptovirology' are terms recalling war gears. In fact, concepts of attack and defence drive the world of computer virology, which looks like a war universe in an information society. This war has several shapes, from invasions of a network by worms, to military and industrial espionage ...

Science.gov (United States)

Theoretically, the outcome of World War II in Europe hung in the balance as the Allies poured onto the Normandy beachhead. Following the June 6, 1944 invasion, the Allies continue to come ashore, massively building up men and material inside the beachhead...

Science.gov (United States)

... 2003)050[0600:LBOTMP]2.0.CO;2 Lectin Binding of the Major Polar Tube Protein (PTP1) ... PTP1. We, therefore, undertook a study ...

Science.gov (United States)

... trees, data showing a better fit to a power model than to a negative exponential model. Invading Pinus ... power law models were significantly negative. The inverse power model accounted for a considerabl...

Science.gov (United States)

(hidróxido de calcio o cal hidratada) como un plaguicida en un programa de cuarentena para controlar la especie invasora, el coquí. Hawai está preocupada de que estos...

UK PubMed Central (United Kingdom)

Candida albicans frequently causes superficial infections by invading and damaging epithelial cells, but may also cause systemic infections by...Full Text Available

UK PubMed Central (United Kingdom)

RATIONALE AND OBJECTIVESNon-invasive longitudinal imaging of tumor vasculature could provide new insights into the development of solid tumors, facilitating efficient...Full Text Available

UK PubMed Central (United Kingdom)

The performance of the Lung Imaging Fluorescence Endoscope (LIFE) system was compared with conventional bronchoscopy in 158 patients: 68 patients with invasive cancer, 42 patients with abnormal sputum...Full Text Available

UK PubMed Central (United Kingdom)

BackgroundBlood sampling through heel lancing is the most common invasive painful procedure performed on newborn infants.Case PresentationWe report...Full Text Available

UK PubMed Central (United Kingdom)

The pharynx is the primary reservoir for strains of group A Streptococcus (GAS) associated both with pharyngitis (streptococcal sore throat) and with invasive or “flesh-eating”...Full Text Available

UK PubMed Central (United Kingdom)

Many species introduced by humans for social and economic benefits have invaded new ranges by escaping from captivity. Such invasive species can negatively affect biodiversity and economies. Understanding...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

Authors retrospectively analyzed the CT findings of mediastinal lesions in surgically or clinically confirmed 37 cases at Kosin Medical College during recent 4 years from September 1979 to August 1983. 1. Among 37 caes, malignant lymphoma were 7 cases, thymoma and vascular lesion or anomaly were 5 cases respectively, benign teratoma and tuberculous mediastinal lymphadenitis and neurogenic tumor were 4 cases respectively, pericardial cyst were 2 cases, bronchogenic cyst, non-specific cyst, pancreatic pseudocyst, mesothelioma, Bochdalek hernia was 1 case respectively. 2. The sex ratio between male and female was about 1 : 1 and the majority of the patients with malignant lymphoma and teratoma was under 20 years old. 3. CT findings of the each mediastinal lesion. 1) Primary mediastinal malignant lymphoma. (1) A large, matted, continuous and midline-crossing mass was observed in the superior and the anterior mediastinums in all cases. (2) In 3 cases, irregular lower ...

Energy Technology Data Exchange (ETDEWEB)

Planning is an important part of computational model verification and validation (V&V) and the requisite planning document is vital for effectively executing the plan. The document provides a means of communicating intent to the typically large group of people, from program management to analysts to test engineers, who must work together to complete the validation activities. This report provides guidelines for writing a validation plan. It describes the components of such a plan and includes important references and resources. While the initial target audience is the DART Full System Model teams in the nuclear weapons program, the guidelines are generally applicable to other modeling efforts. Our goal in writing this document is to provide a framework for consistency in validation plans across weapon systems, different types of models, and different scenarios. Specific details contained in any ...

UK PubMed Central (United Kingdom)

BackgroundThe objective of this study was to develop and validate a daily electronic Endometriosis Pain and Bleeding Diary (EPBD) for assessing treatment-related changes in endometriosis...Full Text Available

UK PubMed Central (United Kingdom)

The validation parameters for pharmaceutical analyses were examined for the accelerator mass spectrometry measurement of ¹⁴C/C ratio, independent of chemical separation procedures....Full Text Available

Science.gov (United States)

... It is recommended that the drawings be validated in accordance with NAVAIRINST 4333.10 and the data package, Appendix A, be used for ...

Science.gov (United States)

... During operations, the system successfully treated Phosgene (CG), chloropicrin (PS), a smoke-generating formulation based on hexachloroethane ...

Science.gov (United States)

In view of the findings that several Kunitz-type protein inhibitors suppress tumor invasion and metastasis, the aim of the present study is to explore whether Bungarus multicinctus protease inhibitor-like protein-2 (PILP-2) and PILP-3 exhibit anti-tumor activity. Although approximately 28% of amino acid substitutions occurred between PILP-2 and PILP-3, molecular modeling suggested that PILP-2 and PILP-3 shared similar folded structures. Unlike PILP-2, PILP-3 showed a notable activity in abolishing migration and invasion of human neuroblastoma SK-N-SH cells. The ability of PILP-3 to inhibit matrix metalloprotease-2 (MMP-2) activity was higher than that of PILP-2. Pull-down assay revealed protein-protein interaction between PILP-3 and MMP-2. In contrast to mutation on N-terminal region, replacement of amino acids at C-terminus attenuated notably the ability of PILP-3 to inhibit cell invasion, cell migration and MMP-2 activity ...

Science.gov (United States)

Ionizing radiation is a standard treatment for various human solid tumors. However, several clinical studies showed that a significant proportion of patients undergoing radiotherapy for hepatocellular carcinoma (HCC) develop intrahepatic and extrahepatic metastasis. Understanding of radiation-induced cancer cell invasiveness and behavior is essential and of great important for developing suitable treatment strategies to contain cancer spread. Therefore, in this study we evaluated the effectiveness of using swept source optical coherence tomography (SS-OCT) to monitor the enhancement of HCC cell invasiveness by radiation. SS-OCT images were acquired and recorded to obtain three-dimensional data sets per four hours in 48 hours after irradiating HepG2 cells with 7.5 Gy. The cell migration behavior in three-dimensional tissue models was quantified from images of radiation-induced and sham-irradiated cells.

Energy Technology Data Exchange (ETDEWEB)

Research highlights: {yields} Mathematical model represents a power system which consists of synchronous machine connected to infinite bus through transmission line. {yields} Power system stabilizer was designed based on optimal pole shifting controller. {yields} The system performances was tested through load disturbances at different operating conditions. {yields} The system performance with the proposed optimal pole shifting controller is compared with the conventional pole placement controller. {yields} The digital simulation results indicated that the proposed controller has a superior performance. -- Abstract: Power system stabilizer based on optimal pole shifting is proposed. An approach for shifting the real parts of the open-loop poles to any desired positions while preserving the imaginary parts is presented. In each step of this approach, it is required to solve a first-order or a second-order linear matrix Lyapunov equation for shifting one real pole or two complex ...

Energy Technology Data Exchange (ETDEWEB)

A thermophotovoltaic (TPV) generator for electric vehicles has been designed and developed. In this paper we focus on the combustion system and the heat regenerator. The system has been designed to work as a range extender for electric vehicles. This solution would provide energy always available on the vehicle, which would run even if the battery level were low. Several configurations for the burner and for the heat exchanger have been investigated and a comparison of these is presented. The different solutions have been studied both theoretically and experimentally. In this paper, we report on the work carried out to build a TPV device capable of yielding 6 kW of electric power to recharge the battery pack of an electric city-car. The project has been divided into four steps: (1) pre-design of different configurations of the burner and heat exchanger using non-commercial software 'TPV Design Tool 1.0'; (2) testing of the pre-designed generators ...

International Nuclear Information System (INIS)

This is the 1st revision of the INIS/ETDE Joint Thesaurus. It contains 20 953 valid descriptors and 8 600 forbidden terms. It was last updated in December 2003. The Joint Thesaurus contains the controlled terminology for indexing all information within the subject scope of both INIS (International Nuclear Information System) and ETDE (Energy Technology Data Exchange) information systems. The terminology is intended for use in subject description for input or retrieval of information in those systems. The thesaurus is a terminological control device used in translating from the natural language of documents, indexers or users into a more constrained system language It is also a controlled and dynamic vocabulary of semantically and generically related terms which covers a specific domain of knowledge. The domain of knowledge covered by this Thesaurus includes physics (in particular, plasma physics, atomic and molecular physics, and especially nuclear and high-energy ...

International Nuclear Information System (INIS)

Three-dimensional computer simulation and analyses of the horizontal steam generator thermal-hydraulics of the WWER 1000 nuclear power plant have been performed for 50% and 75% partial loads, 100% nominal load and 110% over-load. Presented results show water and steam mass flow rate vectors, steam void fraction spatial distribution, recirculation zones, swell level position, water mass inventory on the shell side, and other important thermal-hydraulic parameters. The simulations have been performed with the computer code 3D ANA, based on the 'two-fluid' model approach. Steam-water interface transport processes, as well as tube bundle flow resistance, energy transfer, and steam generation within tube bundles are modelled with "closure laws". Applied approach implies non-equilibrium thermal and flow conditions. The model is solved by the control volume procedure, which has been extended in order to take into account the 3D flow of liquid and gas phase. The ...

Energy Technology Data Exchange (ETDEWEB)

One of the Eddy Current Testing issues in aeronautics is the inspection of fastened structures to detect flaws nearby rivets which can grow because of mechanical stress. EADS and the CEA LIST have started a collaborative work with the support of the Ile-de-France Region to develop a simulation tool of EC fastened structures testing, integrated to the CIVA platform, aimed at conceiving testing methods, optimizing and qualifying it. The volume integral method using the Green dyadics formalism has been chosen in order to get a fast resolution of Maxwell equations. A first milestone was to build a simulation model of multilayer structures testing, thanks to the use of the multilayer Green dyads. Because of the rivet volume, 60 times bigger than the one of a typical flaw, a large number of discretization cells are needed. Therefore an iterative method has been developed in order to numerically solve large calculation zones. Finally, the flaw response simulation mostly has to cope with a ...

Energy Technology Data Exchange (ETDEWEB)

Qualitative interpretation of data of different nature and sources, based on segmentation techniques such as discriminant analysis, is useful to characterize and monitor hydrocarbon reservoirs. In order to make this interpretation more reliable, it is necessary to characterize uncertainties attached to data and then, to propagate them in the interpretation work-flow. In this thesis, uncertainties are represented by intervals, because usually, little is known about input data errors. The uncertainty characterization issue is dealt with specifically for each case study. The uncertainty propagation issue is treated by a new technique, based on interval analysis, which consists in extending to intervals various popular approaches (non parametric, quadratic and linear) to discriminant analysis: Firstly, a learning phase allows calibrating an imprecise classifying model on the basis of pre-interpreted data. If the quality of this model is good enough, it is used to ...

Energy Technology Data Exchange (ETDEWEB)

Attention Deficit Hyperactivity Disorder (ADHD) is a neurobiological disorder of early childhood onset. Defining symptoms are chronic impairments of attention, impulse control and motor hyperactivity that frequently persist until adulthood. Miscellaneous causes of the disorder have been discussed. Accumulating evidence from imaging- and molecular genetic studies strengthened the theory of ADHS being a predominantly inherited disorder of neurobiological origin. In the last 15 years, non-invasive brain imaging methods were successfully implemented in pediatric research. Functional magnetic resonance imaging studies gave major insight into the neurobiological correlates of executive malfunction, inhibitory deficits and psychomotoric soft signs. These findings are in good accordance with brain morphometric data indicating a significant volumetric decrease of major components of striato-thalamo-cortical feedback loops, primarily influencing prefrontal executive ...

British Library Electronic Table of Contents (United Kingdom)

Biological control agents can be more effective if their populations are genetically diverse, particularly when the target invasive plant comprises a range of genotypes with different susceptibilities and occurs across various microclimates. We report on the use of an efficient approach to find, in the native range, diverse isolates of a rust fungus for biological control. An outdoor trap garden containing various clones of invasive European blackberry (Rubus fruticosus agg.) collected in Australia, each with a different DNA phenotype, was established in France. Within 4?weeks of establishment, the leaf-rust fungus Phragmidium violaceum was recovered from all clones in the garden. Molecular analyses of eight recovered and purified isolates of the fungus from the garden revealed that they w...

British Library Electronic Table of Contents (United Kingdom)

Individuals with sickle cell disease (SCD) demonstrate an increased susceptibility to invasive bacterial infections (IBI). The most common organisms causing IBI are Streptococcus pneumoniae, nontyphi Salmonella species and Haemophilus influenzae type b (Hib). IBI are the most common causes of death in children below 5 years of age with SCD. Increased susceptibility to IBI is because of several factors including dysfunctional antibody production and opsonophagocytosis as well as defective splenic clearance. Early diagnosis of Hib and pneumococcal infections combined with antibiotic prophylaxis and immunization programs, could lead to significant improvements in mortality, especially in Africa. Pediatr Blood Cancer. 2010;55:401-406. Copyright 2010 Wiley-Liss, Inc.

British Library Electronic Table of Contents (United Kingdom)

A 2-year-old, female spayed, domestic shorthair cat presented to the University of Missouri-Veterinary Medical Teaching Hospital (UMC-VMTH) with an approximately 11-month history of fluid-draining pockets along her ventral thorax and axillae. The skin in these regions was erythematous, and multiple areas drained a serous to serosanguinous fluid. Fluid-filled, nodules formed along the ventrum, but these nodules disappeared as fluid drained spontaneously. Histologic assessment of skin biopsies revealed areas of vascular proliferation extending along the deep margin of the section and rare instances of invasion into the superficial dermis. These vascular channels were devoid of cells, lined by variably pleomorphic endothelial cells which had a low mitotic index. Based on the mild to moderate ...

British Library Electronic Table of Contents (United Kingdom)

Erythroid differentiation regulator (Erdr1) was first discovered in mouse leukemia cell lines and functions as a stress-related survival factor. This study investigated whether Erdr1 regulates murine melanoma progression, as well as the mechanism involved in Erdr1-regulated metastasis. The expression of Erdr1 is negatively correlated with IL-18 expression, which has a pro-cancer effect in melanoma. To study the role of Erdr1 as an anti-cancer factor, cell migration, invasion, and proliferation were measured. Erdr1 overexpression markedly inhibited the level of cell migration, invasion, and proliferation in B16F10 cells in vitro. In addition, Erdr1 overexpression significantly suppressed melanoma lung colonization, metastasis, and tumor growth in vivo. To identify the factors involved in Er...

Energy Technology Data Exchange (ETDEWEB)

CT findings were compared retrospectively between 9 cases with malignant lymphoma of the anterior mediastinum and 8 cases with invasive thymoma. CT findings of malignant lymphoma were as follows: (1) The majority of the tumors were bilateral and extended beyond the anterior mediastinum to the other mediastinum compartments. (2) Their margin was either smooth or lobulated. (3) Their density was either homogeneous or heterogeneous. In the case with heterogeneous density, ring, triangle and/or band-like low density areas, just like interspace of fused lymph nodes, were demonstrated. Calcification or cysts could not be shown. (4) Patent inherent vessels without deviation were occasionally demonstrated running through the tumors. (5) The tumors faced and contacted widely to anterior chest wall and often pressed the lung laterally at the anterior parietomediastinal pleural reflection. (6) Pleural implants were not demonstrated. (author).

Energy Technology Data Exchange (ETDEWEB)

Full text of publication follows: Different to the very simple class of homogeneous non-equilibrium models (HEM) an one dimensional thermal-hydraulic theoretical drift-flux based and thus non-homogeneous coolant channel model and, as a result, an in itself complete thermal-hydraulic coolant channel module CCM have been established allowing to simulate in a very general way the steady state and transient behaviour of the most important parameters of a single- or two-phase fluid flowing within any type of heated or non-heated coolant channel (with an eventually varying cross flow area). To avoid mathematical discontinuities at the transition from single- to two-phase flow the coolant channel will, in its general form, be split into different regions, i.e. be looked as a basic channel (BC) which can consist of a number of different flow regimes and can, accordingly, be subdivided into a number of sub-channels (SC-s). All of ...

Energy Technology Data Exchange (ETDEWEB)

This dissertation is concerned with the development, experimental diagnostics and mathematical modelling and simulation of polymer electrolyte fuel cells (PEFC). The central themes throughout this thesis are the closely interlinked phenomena of mass and charge transfer. In the face of developing a PEFC system for vehicle propulsion these phenomena are scrutinized on a broad range of relevant scales. Starting from the material related level of the membrane and the gas diffusion layer (GDL) we turn to length scales, where structural features of the cell additionally come into play. These are the scale of flow channels and ribs, the single cell and the cell stack followed by the cell, stack, and system development for an automotive power train. In Chapter 3 selected fundamental material models and properties, respectively, are explored that are crucial for the mathematical modelling and simulation of PEFC, as needed in some succeeding parts of this work. First, established mathematical ...

Science.gov (United States)

The authors describe an effect of suppression of invasion of the guinea pig eye conjunctiva and the HEp-2 epithelial cells by virulent Sh. flexneri bacilli, with a simultaneous administration of the same dose of avirulent shigella mutants, genetically connected with them. The data of morphological study and experiments with 3H-glucose labeled shigellae carried out on the cell species model indicated that the bacterial competition for the specific sites for absorption on the epithelial cells underlay the observed phenomenon. PMID:331774

UK PubMed Central (United Kingdom)

Pneumococcal disease in young children has not been as well characterized in East Africa as it has been in industrialized countries. Although pneumococci are likely to cause substantial mortality...Full Text Available

UK PubMed Central (United Kingdom)

We have demonstrated that the 80 kDa POP Tc80 (prolyl oligopeptidase of Trypanosoma cruzi) is involved in the process of cell invasion, since specific inhibitors block parasite...Full Text Available

International Nuclear Information System (INIS)

Breast cancer represents today more than 30% of all cancers and is responsible for about 20% of deaths due to cancer. The potentialities of mammography have increased in recent years through improvements in equipment and methodologies. In this paper the conventional mammography using film and image intensifiers is compared with digital mammography. Digital mammography presents clear advantages in storage and handling of information. Also its higher sensitivity will lead to an earlier detection of anomalies and a decrease in the number of invasive exams and surgeries

UK PubMed Central (United Kingdom)

Newly hatched chicks were dosed orally with a Salmonella typhimurium wild-type strain, an S. enteritidis wild-type strain, and a genetically defined S. enteritidis aroA vaccine candidate, strain CVL30....Full Text Available

British Library Electronic Table of Contents (United Kingdom)

Primary peritoneal malignant mixed mullerian tumors are very rare. We report the case of a patient presenting with pain in the right upper quadrant of the abdomen and in whom the physical examination demonstrated a peritoneal mass. Computed tomography (CT) confirmed the presence of a mass, with invasion of adjacent organs.

International Nuclear Information System (INIS)

CT-guided fine needle aspiration biopsy (FNAB) is known to improve diagnosis of expansive abdominal lesions, especially relative to more invasive procedure like explorative laparotomy. FNAB in not commonly use in pediatric patients because of their poor collaboration and of associated risks. The authors investigated the feasibility of FNAB in the pediatric age.

Science.gov (United States)

C. Learning Curve. The learning curve concept has long been recognized and ...... F4. TERMIA. S - STATION EQUIPMENT. V - VLBI VALIDATION EQUIPMENT ...

UK PubMed Central (United Kingdom)

BACKGROUND:In adults, it is well known that high levels of pain catastrophizing are related to increased pain and disability as well as to heightened anxiety and depression. However,...Full Text Available

UK PubMed Central (United Kingdom)

SynopsisAttention-deficit / hyperactivity disorder (ADHD) is a valid and impairing psychological disorder that persists into adulthood in a majority of cases and is associated...Full Text Available

CERN Document Server

Inferring cluster structure in microarray datasets is a fundamental task for the -omic sciences. A fundamental question in Statistics, Data Analysis and Classification, is the prediction of the number of clusters in a dataset, usually established via internal validation measures. Despite the wealth of internal measures available in the literature, new ones have been recently proposed, some of them specifically for microarray data. In this dissertation, a study of internal validation measures is given, paying particular attention to the stability based ones. Indeed, this class of measures is particularly prominent and promising in order to have a reliable estimate the number of clusters in a dataset. For those measures, a new general algorithmic paradigm is proposed here that highlights the richness of measures in this class and accounts for the ones already available in the literature. Moreover, some of the most representative ...

UK PubMed Central (United Kingdom)

BackgroundAdequate pain assessment is critical for evaluating the efficacy of analgesic treatment in clinical practice and during the development of new therapies. Yet the currently...Full Text Available

Science.gov (United States)

Information about surface soil moisture conditions is of critical importance to real-world applications such as agricultural production, water resource management, flood prediction, fire prediction, water supply, military mobility, etc.. Near-surface soil moisture is currently available from non-ideal sensor configuration observations, and two missions targeted at measuring near-surface soil moisture with ideal sensor configuration are expected before the end of the decade (the European Space Agency (ESA), Soil Moisture and Ocean Salinity (SMOS) mission, and the National Aeronautics and Space Administration (NASA), Hydrospheric states "Hydros" mission). Though remote sensing can make spatially comprehensive measurements of surface soil moisture, it cannot provide information on the entire land surface hydrologic system, and the measurements represent only a snap shot in time. Alternatively, land surface hydrology process models may be used to predict the temporal ...

Science.gov (United States)

The Defense Advanced Research Projects Agency (DARPA) inaugurated a program addressing research and development for an Exoskeleton for Human Performance Augmentation in FY!2001. A team consisting of Oak Ridge National Laboratory, the prime contractor, AeroVironment, Inc., the Army Research Laboratory, the University of Minnesota, and the Virginia Polytechnic Institute has recently completed an 18-month Phase I effort in support of this DARPA program. The Phase I effort focused on the development and proof-of-concept demonstrations for key enabling technologies, laying the foundation for subsequently building and demonstrating a prototype exoskeleton. The overall approach was driven by the need to optimize energy efficiency while providing a system that augmented the operator in as transparent manner as possible (non-impeding). These needs led to the evolution of two key distinguishing features of this team's approach. The first is the ...

British Library Electronic Table of Contents (United Kingdom)

The International Index of Erectile Function is a well-worded and psychometrically valid self-report questionnaire widely used as the standard for the evaluation of male sexual function. However, some conceptual and statistical problems arise when using the measure with men who are not sexually active. These problems are illustrated using 2 empirical examples, and the authors provide recommended solutions to further strengthen the efficacy and validity of this measure.

Energy Technology Data Exchange (ETDEWEB)

Piping in nuclear power plants is vital to the proper operation and safety of these facilities. To assure safety in the unlikely event of a pipe break, it is necessary to evaluate the consequences from the resulting whipping pipe on neighboring components and structures. Numerical simulations allow for rapid evaluation of these consequences. Before simulations can be accepted, however, the methodology and computer codes must be validated against experimental results. This paper uses a probabilistic approach to validate pipe whip simulations against limited experimental results. Probabilistic analysis software was developed and coupled to existing deterministic finite element software. An example of a whipping pipe impacting against a reinforced concrete slab was simulated. The described probabilistic approach was used to validate the numerical simulations. The conclusions obtained were that the numerical simulations of ...

CERN Document Server

The purpose of this paper is to present the extended definitions and characterizations of the classical notions of APN and maximum nonlinear Boolean functions to deal with the case of mappings from a finite group K to another one N with the possibility that one or both groups are non-Abelian.

Science.gov (United States)

complexe sur paroi non-isotherme, LContri5ution to the Study thermal ... paroi chaude essentiellement non-isotherme, LVaporization in a Complex ...

Energy Technology Data Exchange (ETDEWEB)

Magnetic resonance imaging (MRI) as a diagnostic imaging tool relies on the generation of magnetic fields, whereas the computerized tomography (CT) uses X-radiation. The fundamental principle of MRI is the magnetic resonance of paramagnetic atomic nuclei. These nuclei, as e.g. protons (= hydrogen nuclei), are aligned in required orientation by application of a strong magnetic field. Upon simultaneous application of an electromagnetic high-frequency field perpendicular to the axis of the basic magnetic field, and in response to periodical changing of the electromagnetic field at a given frequency, the originally aligned paramagnetic nuclei are forced into a movement similar to that of a ``whipping top``. When the resonance frequency is shut off, the nuclei return to their former, aligned positions, inducing a weak signal in a coil. The series of signals generated by multiple repetition of this process of excitation of nuclei and their return to aligned rest is used as input to a ...

Science.gov (United States)

Based on studies on the genetic and molecular basis of Shigella flexneri invasive properties, we have constructed and evaluated a double mutant of S. flexneri serotype 5 for utilization as a live attenuated oral vaccine against shigellosis. The first mutation, icsA, blocks intracellular spread of bacteria as well as cell-to-cell infection. It affects the capacity of the invasive pathogen to form large abscesses in epithelia. The second mutation, iuc, eliminates production of the siderophore aerobactin thus impairing growth of the bacterium within tissues. This double mutant, SC5700 appeared safe when administered intragastrically to macaque monkeys as three doses (5 x 10(10) c.f.u. each) at weekly intervals. Protection against a challenge by the wild type isolate (M90T) was observed 4 weeks after the last vaccine inoculation. Duration of carriage was considerably reduced as compared to the control group in which all animals had developed severe ...

Science.gov (United States)

The results of experimental studies on the contribution of zoogenic debris to transformation of soil properties in the southern taiga subzone of Central Siberia are analyzed. They show that water-soluble carbon outflow from the forest litter increases by 21-26% upon a Siberian moth invasion, with this value decreasing to 14% one year later. The burning of forest in an area completely defoliated by the pest leads to changes in the stock, fractional composition, actual acidity, and ash element contents of the litter. The litter-dwelling invertebrate assemblage is almost completely destroyed by fire and begins to recover only after two years. PMID:18491565

Wastenet

...soy, rights, justice, contamination, water, cargill, port soy, rights, justice, contamination, water, cargill, port Friends of the ... The global food giant Cargill has built its own port on the banks of the River Paraguay with plans to expand. It's ...allows Puerto Union, the port facility belonging to the transnational food giant Cargill, to continue operating. This decree was issued despite the ... The Cargill port facility represents a hazard to the water supply of the entire population of the city, and any accident such ...

Energy Technology Data Exchange (ETDEWEB)

The usefulness of helical CT early phase images optimized by the SmartPrep method for evaluation of wall invasion by colorectal cancer was investigated. Between August 1997 and September 1998, CT was performed to evaluate the primary tumor and local extension in 10 consecutive patients with colorectal cancer confirmed by barium enema- and/or colonoscopy. Early-phase images were acquired by using SmartPrep application software. This method allows the optimal scan delay time to be obtained by continuous monitoring of increases in CT values after injection of contrast medium. Sections of the surgical specimens, close to the same plane as the CT images, and of the same slice thickness, were analyzed histopathologically. All 10 cancers, regardless of size, showed strong enhancement on the early-phase images (81.4-112 HU, mean: 95.1 HU). The strongly enhanced image areas on CT corresponded to the primary cancer areas on histopathological specimens. A low-density zone was ...

International Nuclear Information System (INIS)

Full text: Pink bollworm (PBW), Pectinophora gossypiella (Saunders), an introduced pest from Mexico, first occurred in United States cotton production in Texas in 1917. Unacceptable economic losses have occurred. The development of PBW sterile moth release technology, gossyplure sex pheromone behavioral control, cotton plant cultural control to reduce overwintered PBW populations, and the transfer of the insect toxin protein gene into cotton from Bacillus thuringiensis kurstaki (Berliner) have provided an effective integrated pest management (IPM) system with PBW eradication potential. Sterile insect release was considered a potential option for PBW population suppression in the early 1960s. Research on the isolated island of St. Croix, (US Virgin Islands) demonstrated its validity. Reductions of larval infestations in bolls following sterile moth releases began when ratios of released PBW sterile male to native male moths averaged 70:1 in gossyplurebaited traps. ...

British Library Electronic Table of Contents (United Kingdom)

Two studies (N = 420) were conducted to develop and validate the instructional dissent scale (IDS) for use in the college classroom. Participants in study 1 were 210 students who completed the IDS pilot inventory which was subjected to an exploratory factor analysis yielding three distinct factors of dissent (i.e., expressive, rhetorical, vengeful). Concurrent validity support was provided as perceived teacher misbehaviors were associated positively with students' likelihood of engaging in dissent and students reported fewer learning outcomes when they dissented. Participants in study 2 were from a different sample of 210 students who completed the IDS along with measures of classroom justice and student challenge behavior. A confirmatory factor analysis provided support for the hypothesiz...

Science.gov (United States)

Sandia National Laboratories has erected a research oriented, 34- meter diameter, Darrieus vertical axis wind turbine near Bushland, Texas. This machine, designated the Sandia 34-m VAWT Test Bed, is equipped with a large array of strain gauges that have been placed at critical positions about the blades. This manuscript details a series of four-point bend experiments that were conducted to validate the output of the blade strain gauge circuits. The output of a particular gauge circuit is validated by comparing its output to equivalent gauge circuits (in this stress state) and to theoretical predictions. With only a few exceptions, the difference between measured and predicted strain values for a gauge circuit was found to be of the order of the estimated repeatability for the measurement system.

British Library Electronic Table of Contents (United Kingdom)

The aim of this work is the development and experimental validation of a detailed dynamic fuel cell model using the gPROMS modeling environment. The model is oriented towards optimization and control and it relies on material and energy balances as well as electrochemical equations including semi-empirical equations. For the experimental validation of the model a fully automated and integrated hydrogen fuel cell testing unit was used. The predictive power of the model has been compared with the data obtained during load change experiments. A sensitivity analysis has been employed to reveal the most critical empirical model parameters that should be estimated using a systematic estimation procedure. Model predictions are in good agreement with experimental data under a wide range of operati...

Energy Technology Data Exchange (ETDEWEB)

RELAP5/MOD3 code was developed for western type power water reactors with vertical steam generators. Thus, this code should be validated also for VVER design with horizontal steam generators. The validation work, which has been started in Lappeenranta University of Technology (LUT), has already shown some weaknesses of the code. For example the flow inside a steam generator horizontal tube in some accident cases is not correctly modelled by the code. It may be the result of erroneous prediction of the flow regime. The aim of the study is the attempt of verification of the flow regime map, which is used in the RELAP5/MOD3 computer code for two-phase flow in horizontal tubes. (18 refs.).

British Library Electronic Table of Contents (United Kingdom)

Research on the emotion of shame has increased significantly in recent years. However, there remains a need for more psychometrically sound measures of shame, including measures of shame in response to specific, idiographic experiences. The Shame Inventory was developed in order to assess both global feelings of shame as well as shame in response to specific life events or personal characteristics. Two studies were conducted to determine the preliminary psychometric properties of the Shame Inventory. Across both studies, results indicate that the inventory has high internal consistency, test-retest reliability, construct validity, and predictive validity. The Shame Inventory holds promise as a new measure designed to assess both global feelings of shame as well as specific shame-eliciting ...

Energy Technology Data Exchange (ETDEWEB)

No abstract prepared.

Science.gov (United States)

DC Field, Value, Language.

KoreaScience (Korea)

Full Text Available

International Science & Technology Center (ISTC)

Highly Precision Method for Nondestructive Analysis of Surfaces in a Subnanometer Depth Range

Wastenet

for municipal waste iron ore sinter plants incinerators for clinical waste facilities of the non-ferrous metal

KoreaScience (Korea)

Full Text Available

Wastenet

all Certified ESM facilities capable of receiving used mobile phone waste from non-Annex VII countries.

International Nuclear Information System (INIS)

Short communication.

KoreaScience (Korea)

Full Text Available

Science.gov (United States)

Studies in our wound ballistics laboratory have shown that excellent healing can occur in complicated assault rifle wounds that are free of tension and well drained. A conservative approach to debridement and excision of tissue in uncomplicated extremity wounds may be a valid and resource-saving technique. PMID:2366941

UK PubMed Central (United Kingdom)

BackgroundStrategies to accurately identify the occurrence of specific health care events in administrative data is central to many quality improvement and research efforts. Many...Full Text Available

UK PubMed Central (United Kingdom)

Borrelial infection may manifest with a wide range of clinical signs, and in many cases, microbiological findings are essential for a proper diagnosis. This study included 48 patients with a working...Full Text Available

UK PubMed Central (United Kingdom)

Human epidermal growth factor receptor 2 (HER2) is one of the most important prognostic and predictive factors for breast cancer patients. Recently, serum HER2...Full Text Available

UK PubMed Central (United Kingdom)

Lifetime exposure to physical activity is an important construct for evaluating associations between physical activity and disease outcomes, given the long induction periods in many chronic diseases....Full Text Available

UK PubMed Central (United Kingdom)

Although the Kaiser Physical Activity Survey (KPAS) was a potential instrument for cross cultural research of midlife women, little information is available on its reliability and validity among...Full Text Available

UK PubMed Central (United Kingdom)

We have developed and validated a microporous poly(ethylene terephthalate) membrane-based indirect co-culture system for human pluripotent stem cell (hPSC) propagation, which allows real-time...Full Text Available

UK PubMed Central (United Kingdom)

OBJECTIVE. This study was conducted to determine whether an index for measuring quality of care for psychiatric emergencies is reliable and valid. DATA SOURCES/STUDY SETTING. The study used primary...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

NUPEC has carried out hydrogen mixing tests to investigate hydrogen distribution behavior within a model containment and to provide a set of experimental data for validation of severe accident analysis codes.

UK PubMed Central (United Kingdom)

ObjectiveTo examine the validity of the Patient Health Questionnaire - 2 (PHQ-2), a 2-item depression screening scale among adolescents.Full Text Available

UK PubMed Central (United Kingdom)

Purpose:To investigate the clinical usage of dose verification of Helical Tomotherapy plans by using 2D-array ion chambers, and to develop an efficient way to validate the dose delivered...Full Text Available

UK PubMed Central (United Kingdom)

Attention has shifted from the treatment of colorectal cancer (CRC) to chemoprevention using aspirin and folic acid as agents capable of preventing the onset of colon cancer. However, no sensitive...Full Text Available

Science.gov (United States)

Page 1. Page 2. Page 3. Page 4. Page 5. Page 6. Page 7. Page 8. Page 9. Page 10. Page 11. Page 12. Page 13. Page 14. Page 15. Page 16. Page ...

UK PubMed Central (United Kingdom)

Mass balance relations, valid for any counterflow system, are derived and applied to a central core model of the renal medulla, in which descending Henle's limbs (DHL), ascending Henle's limbs (AHL),...Full Text Available

UK PubMed Central (United Kingdom)

Objective:To estimate the prevalence of insulin resistant syndrome (IRS) among newly diagnosed patients with type 2 diabetes and to test their validity against two indices...Full Text Available

UK PubMed Central (United Kingdom)

BackgroundThe Canadian Emergency Department Triage and Acuity Scale (CTAS) is a well recognized and validated triage system that prioritizes patient care by severity of illness....Full Text Available

UK PubMed Central (United Kingdom)

Validation of body-mass relationships requires a careful statistical analysis of data of normal weight individuals. BMI (ratio between body mass and square of body height) and BSI values (ratio between...Full Text Available

Science.gov (United States)

include modeling geometric complexities, coupling between the flow and the .... noted that the AGARD 445.6 wing data set, which has been widely used for .... higher-level computational aeroelastic code validations at transonic flow separation ...

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Large-scale cancer genome projects will soon be able to sequence many cancer genomes to comprehensively identify genetic changes in human cancer. Genome-wide association studies have also identified...Full Text Available

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The purpose of this study was to assess the utility of the Arabic translation of the Alcohol Use Disorders Identification Test (AUDIT) among a sample of male Muslim prisoners (N = 107) in Dubai, United Arab Emirates (UAE). Confirmatory factor analysis indicated a two-factor model to be the best fit of the data. Good internal reliability (a =.91) and predictive validity were also observed. While the limitations of the study are observed, these promising results suggest that the Arabic version of the AUDIT is a reliable and sound measure of alcohol use disorders among prisoners in the UAE.