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Eight selected sulfonamide drugs were investigated as inhibitors of heat shock protein 90 (Hsp90). The investigation included simulated docking experiments to fit the selected compounds within the binding pocket of Hsp90. The selected molecules were found to readily fit within the ATP-binding pocket of Hsp90 in low-energy poses. The sulfonamides torsemide, sulfathiazole, and sulfadiazine were found to inhibit the ATPase activity of Hsp90 with IC50 values of 1.0, 2.6, and 1.5 mM, respectively. Our results suggest that these well-established sulfonamides can be good leads for subsequent optimization into potent Hsp90 inhibitors.

UK PubMed Central (United Kingdom)

BackgroundMolecular docking methods are commonly used for predicting binding modes and energies of ligands to proteins. For accurate complex geometry and binding energy estimation,...Full Text Available

Science.gov (United States)

... Standards Validation Group National Computer Systems Laboratory National Institute of Standards and Technology ... STANDARD. ... (See test Ci )i3A. ...

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GSTD1 is one of several insect glutathione S-transferases capable of metabolizing the insecticide DDT. Here we use crystallography and NMR to elucidate the binding of DDT and glutathione to GSTD1. The crystal structure of Drosophila melanogaster GSTD1 has been determined to 1.1 {angstrom} resolution, which reveals that the enzyme adopts the canonical GST fold but with a partially occluded active site caused by the packing of a C-terminal helix against one wall of the binding site for substrates. This helix would need to unwind or be displaced to enable catalysis. When the C-terminal helix is removed from the model of the crystal structure, DDT can be computationally docked into the active site in an orientation favoring catalysis. Two-dimensional {sup 1}H,{sup 15}N heteronuclear single-quantum coherence NMR experiments of GSTD1 indicate that conformational changes occur upon glutathione and DDT binding and the residues that broaden upon DDT ...

Science.gov (United States)

The German-Russian project that is part of the G8 initiative on Global Partnership Against the Spread of Weapons and Materials of Mass Destruction focuses on the speedy construction of a land-based interim storage facility for nuclear submarine reactor compartments at Sayda Bay near Murmansk. This project includes the required infrastructure facilities for long-term storage of about 150 reactor compartments for a period of about 70 years. The interim storage facility is a precondition for effective activities of decommissioning and dismantlement of almost all nuclear-powered submarines of the Russian Northern Fleet. The project also includes the establishment of a computer-assisted waste monitoring system. In addition, the project involves clearing Sayda Bay of other shipwrecks of the Russian navy. On the German side the project is carried out by the Energiewerke Nord GmbH (EWN) on behalf of the Federal Ministry of Economics and Labour (BMWi). On the Russian side ...

UK PubMed Central (United Kingdom)

All microRNA (miRNA) target—finder algorithms return lists of candidate target genes. How valid is that output in a biological setting? Transcriptome analysis has proven to be a useful approach...Full Text Available

Science.gov (United States)

Milstar 2. (USA 115). 60A. Titan IV. Nov. 12, 1995. Install Docking Module on the Mir space. 396 km. Second of 9 planned flights. Space Shuttle Atlantis ...

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An indicator of when the learning curve reaches a standard is when fuel consumption remains relatively ...... f4 7'tI. 1.i7J43t. F ,oo,. , F17i [ !i ...

UK PubMed Central (United Kingdom)

The Dot/Icm-translocated Ankyrin B (AnkB) F-box effector of Legionella pneumophila is essential for intra-vacuolar proliferation and functions as a platform for the docking of polyubiquitinated...Full Text Available

UK PubMed Central (United Kingdom)

BackgroundComplaints of arm, neck and/or shoulders (CANS) affects millions of computer office workers. However its prevalence and associated risk factors in developing countries...Full Text Available

Science.gov (United States)

This paper presents results of solid-liquid phase change, driven by volumetric energy generation, in a vertical cylinder. We show excellent agreement between a quasi-static, approximate analytical solution valid for Stefan numbers less than one, and a computational model solved using the CFD code FLUENT®. A computational study also shows the effect that the volumetric energy generation has on both the mushy zone thickness and convection in the melt during phase change.

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Piping in nuclear power plants is vital to the proper operation and safety of these facilities. To assure safety in the unlikely event of a pipe break, it is necessary to evaluate the consequences from the resulting whipping pipe on neighboring components and structures. Numerical simulations allow for rapid evaluation of these consequences. Before simulations can be accepted, however, the methodology and computer codes must be validated against experimental results. This paper uses a probabilistic approach to validate pipe whip simulations against limited experimental results. Probabilistic analysis software was developed and coupled to existing deterministic finite element software. An example of a whipping pipe impacting against a reinforced concrete slab was simulated. The described probabilistic approach was used to validate the numerical simulations. The conclusions obtained were that the ...

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RELAP5/MOD3 code was developed for western type power water reactors with vertical steam generators. Thus, this code should be validated also for VVER design with horizontal steam generators. The validation work, which has been started in Lappeenranta University of Technology (LUT), has already shown some weaknesses of the code. For example the flow inside a steam generator horizontal tube in some accident cases is not correctly modelled by the code. It may be the result of erroneous prediction of the flow regime. The aim of the study is the attempt of verification of the flow regime map, which is used in the RELAP5/MOD3 computer code for two-phase flow in horizontal tubes. (18 refs.).

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A spectral element method embodying Large Eddy Simulation based on Re- Normalization Group theory for simulating Sub Grid Scale viscosity was chosen for this work. This method is embodied in a computer code called NEKTON. NEKTON solves the unsteady, 2D or 3D,incompressible Navier Stokes equations by a spectral element method. The code was later extended to include the variable density and multiple reactive species effects at low Mach numbers, and to compute transport of large particles governed by inertia. Transport of small particles is computed by treating them as trace species. Code computations were performed for a number of test conditions typical of flow past a deep tube bank in a boiler. Results indicate qualitatively correct behavior. Predictions of deposition rates and deposit shape evolution also show correct qualitative behavior. These simulations are the first attempts to ...

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Precondition for the low-NO operation of gas turbine burners is the generation of as homogeneous as possible a gaseous fuel/air mixture. Such a burner behavior can be achieved by selective adaptation of the flow and injection. A computing model is introduced that calculates the dynamically balanced GASs/droplet flow through numerical solution of the transport equations in a curved orthogonal coordinate system. The feedback reaction of the fuel droplets to the gas phase is considered by source terms and/or sink terms. Test computations were carried out for comparison with analytical solutions from the flow mechanics and validated by comparison with measurement results. Droplet motion and evaporation were checked by means of published experimental results on single droplets. For the validation of the developed computing technique, model tests were carried out with water in place of ...

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The present paper is concerned with development and application of a so-called Effective Convection Model (ECM), which aims to provide a detailed, mechanistic description of heat transfer processes in a BWR lower plenum. The ECM is a Computational Fluid Dynamics (CFD)-like tool which employs a simpler and more effective approach to compute heat transfer by solving only energy conservation equation instead of solving the full set of Navier-Stokes and energy equations by a CFD code. We implement the ECM in a CFD code (Fluent), with detailed description of the ECM development, implementation and validation. A dual approach is used to validate the ECM, namely validation against experimental data and against heat transfer results obtained by CFD predictions in the same geometries and conditions. Insights gained from CFD simulations are also used to improve ECM. The ECM capability as an ...

Energy Technology Data Exchange (ETDEWEB)

Verification, calibration, and validation (VCV) of Computational Fluid Dynamics (CFD) codes is an essential element of the code development process. The exact manner in which code VCV activities are planned and conducted, however, is critically important. It is suggested that the way in which code validation, in particular, is often conducted--by comparison to published experimental data obtained for other purposes--is in general difficult and unsatisfactory, and that a different approach is required. This paper describes a proposed methodology for CFD code VCV that meets the technical requirements and is philosophically consistent with code development needs. The proposed methodology stresses teamwork and cooperation between code developers and experimentalists throughout the VCV process, and takes advantage of certain synergisms between CFD and experiment. A novel approach to uncertainty analysis is described which can ...

International Nuclear Information System (INIS)

The requirements are given as placed on the development, procurement, maintenance, and application of software for the creation or processing of data during the design, construction, operation, repair, maintenance and safety-related upgrading of nuclear power plants. The verification and validation processes are highlighted, and the requirements put on the software documentation are outlined. The general quality assurance principles applied to safety analyses are characterized. (J.B.). 1 ref.

International Nuclear Information System (INIS)

Two sets of analytical correlations describing transitions between two-phase flow regimes are reviewed and discussed. One, the T-D set, is based on mechanistic models; the other, the Weisman set, on experimental correlations. The T-D set is preferred for horizontal flow, whereas the Weisman set seems preferrable for vertical flow. A computer code (FLOP) based on the T-D theory is described and applied to validate the theory.

UK PubMed Central (United Kingdom)

The docking protein p130Cas is a prominent Src substrate found in focal adhesions (FAs) and is implicated in regulating critical aspects of cell motility including FA disassembly and protrusion of the...Full Text Available

International Nuclear Information System (INIS)

In July 2005 a new algorithm was released by Varian Medical Systems for the Eclipse planning system and installed in our institute. It is the anisotropic analytical algorithm (AAA) for photon dose calculations, a convolution/superposition model for the first time implemented in a Varian planning system. It was therefore necessary to perform validation studies at different levels with a wide investigation approach. To validate the basic performances of the AAA, a detailed analysis of data computed by the AAA configuration algorithm was carried out and data were compared against measurements. To better appraise the performance of AAA and the capability of its configuration to tailor machine-specific characteristics, data obtained from the pencil beam convolution (PBC) algorithm implemented in Eclipse were also added in the comparison. Since the purpose of the paper is to address the basic performances of the AAA and of its ...

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This document reproduces the final project of David San Fabian Ayuso, presented on May 26, 2005, for the obtention of the engineer degree of the Carlos III University of Madrid. A single-phase, isothermal model, including both electron and proton transport, is introduced for the simulation of polymer electrolyte fuel cells (PEM). The model is implemented in the commercial code Fluent 6.0, through the use of UDFs (User Defined Functions). In order to validate the model, a single canal of a PEM monocell is simulated in three dimensions. The obtained result are qualitatively satisfactory. It is observed that it is not essential to solve the current collectors when a monocell is considered (and not a stack). in the present study, the number of nodes is the computational grid appears to be too low in the membrane zone in order to make a complete validation of the model. (Author) 20 refs.

CERN Document Server

This paper gives a concise overview of evolutionary algorithms for multiobjective optimization. A substantial number of evolutionary computation methods for multiobjective problem solving has been proposed so far, and an attempt of unifying existing approaches is here presented. Based on a fine-grained decomposition and following the main issues of fitness assignment, diversity preservation and elitism, a conceptual global model is proposed and is validated by regarding a number of state-of-the-art algorithms as simple variants of the same structure. The presented model is then incorporated into a general-purpose software framework dedicated to the design and the implementation of evolutionary multiobjective optimization techniques: ParadisEO-MOEO. This package has proven its validity and flexibility by enabling the resolution of many real-world and hard multiobjective optimization problems.

International Nuclear Information System (INIS)

The process of ensuring the quality of computer codes can be very time consuming and expensive. The Oak Ridge National Laboratory (ORNL) Monte Carlo codes all predate the existence of quality assurance (QA) standards and configuration control. The number of person-years and the amount of money spent on code development make it impossible to adhere strictly to all the current requirements. At ORNL, the Nuclear Engineering Applications Section of the Computing Applications Division is responsible for the development, maintenance, and application of the Monte Carlo codes MORSE and KENO. The KENO code is used for doing criticality analyses; the MORSE code, which has two official versions, CGA and SGC, is used for radiation transport analyses. Because KENO and MORSE were very thoroughly checked out over the many years of extensive use both in the United States and in the international community, the existing codes were open-quotes baselined.close ...

Energy Technology Data Exchange (ETDEWEB)

A common practice of electric utilities experiencing transmission and distribution (T and D) system overloads is to expand the substation, add lines, or upgrade equipment, all of which are capital intensive options. In 1988, it was hypothesized that strategically sited photovoltaics (PV) could benefit parts of T and D systems near or at overloaded conditions. An evaluation methodology was developed and applied to a test case (Kerman Substation near Fresno, California). Analytical results suggested that the value of PV to the T and D system could substantially exceed its energy and generation capacity value. The importance of this finding indicated the need for empirical validation. This led to the construction of a 0.5 MW PV demonstration plant by Pacific Gas and Electric Company (PG and E) at Kerman, California as part of the PVUSA (PV for Utility Scale Applications) project. PVUSA is a national public-private partnership that is assessing and demonstrating the ...

International Nuclear Information System (INIS)

As the cost of developing completely new computer codes becomes prohibitive, designers of nuclear facilities are turning to more cost-effective approaches for meeting increasingly strict regulatory requirements applied to safety-related analysis. For designing and licensing the MAPLE family of research reactors, Atomic Energy of Canada Ltd. (AECL) is employing the strategy of adapting major existing codes by linking them together within networks of custom-built interface software. This approach builds on the international investment in developing, maintaining, and verifying existing primary codes and focuses on the less onerous development of interface codes. The resultant code systems are then validated for the new applications of interest.

Science.gov (United States)

We have developed a novel laser ray-tracing method to measure aberrations in optical systems. It consists of delivering narrow laser pencils (by a laser scanner), recording the spots that are formed on the image plane (with a CCD camera), and computing the position of each centroid. This approach could be considered an experimental (approximate) implementation of standard numerical ray tracing. Several tests and experiments, including a direct comparison with a Hartmann-Shack wave-front sensor, provided highly satisfactory results that confirmed the validity of the method and revealed potential advantages. PMID:18073906

International Nuclear Information System (INIS)

Dispersed flow film boiling is the heat transfer regime that occurs at high void fractions in a heated channel. The way this transfer mode is modelled in the NRC computer codes (RELAP5 and TRAC) and the validity of the assumption and empirical correlations used is discussed. An extensive review of the theoretical and experimental work related with heat transfer to highly dispersed mixtures reveals the basic deficiencies of these models: the investigation refers mostly to the typical conditions of low rate bottom reflooding, since the simulation of this physical situation by the computer codes has often showed poor results. The alternative models that are available in the literature are reviewed, and their merits and limits are highlighted. The modification that could improve the physics of the models implemented in the codes are identified. (author) 13 figs., 123 refs.

Energy Technology Data Exchange (ETDEWEB)

The plasma plume generated by a new type of high energy Janitor known as the railplug, is examined. The railplug is a miniaturized railgun that has the potential for improving ignition characteristics of combustible mixtures in engines. The objective of the study is to gain an uderstanding of the characteristics of the plasma created by a transparent railplug, and to validate a multidimensional computer simulation of the plasma and shock fronts. The nature of the plume emitted by the railplug was examined for three levels of electrical energy while firing into air at a pressure of 1 atm. The computer model is to be used to predict trends in railplug performance for various railplug designs, energies, and ambient conditions. The velocity of the plasma movement inside a transparent railplug was measured, as well as the velocity of the plume ejected from the cavity. A shock is produced at the initiation point of the arc and ...

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Geological, geophysical, thermal, petrophysical and hydrological data available for the East Mesa hydrothermal system that are pertinent to the construction of a computer model of the natural flow of heat and fluid mass within the system are assembled and correlated. A conceptual model of the full system is developed and a subregion selected for quantitative modeling. By invoking the Boussinesq approximation, valid for describing the natural flow of heat and mass in a liquid hydrothermal system, it is found practical to carry computer simulations far enough in time to ensure that steady-state conditions are obtained. Initial calculations for an axisymmetric model approximating the system demonstrate that the vertical formation permeability of the deep East Mesa system must be very low (k/sub v/ approx. 0.25 to 0.5 md). Since subsurface temperature and surface heat flow data exhibit major deviations from the axisymmetric ...

Science.gov (United States)

A computational fluid dynamics (CFD) is coupled with a computational structural dynamics (CSD) to simulate the unsteady rotor flow with aeroelasticity effects. An unstructured upwind Navier-Stokes solver was developed for this simulation, with 2nd order time-accurate dual-time stepping method for temporal discretization and low Mach number preconditioning method. For turbulent flows, both the Spalart-Allmaras and Menter's SST model are available. Mesh deformation is achieved through a fast dynamic grid method called Delaunay graph map method for unsteady flow simulation. The rotor blades are modeled as Hodges & Dowell's nonlinear beams coupled flap-lag-torsion. The rotorcraft computational structural dynamics code employs the 15-dof beam finite element formulation for modeling. The structure code was validated by comparing the natural frequencies of a rotor model with UMARC. The flow and structure ...

International Nuclear Information System (INIS)

The Accelerator Transmutation Waste System is under development at the Los Alamos National Laboratory. The goal is to perform an independent verification of the feasibility of actinide and long-lived fission product burning in this system. The authors' work is divided into five tasks: (a) production of an actinide and long-lived fission product cross section library from JEF 2.2; (b) simulation using MCNP and KENO IV Monte Carlo codes, of the Accelerator Transmutation Waste System configurations existing in literature; (c) validation of HETC Monte Carlo code (production of spallation source); (d) validation of the cross sections by comparison of Keff and reaction rate results, calculated with MNCP and KENO IV, with experimental benchmarks and intercomparison between the authors' calculations of a PWR unit cell and the computations carried out with various codes and cross section libraries (NEACRP critically group data); and ...

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Squeeze film dampers (SFD) are devices utilized to control vibrations of the shafts of high-speed rotating machinery. The SFD - squirrel cage combination is probably the most used system for tuning the stiffness and damping of the supports for rotors installed on ball bearings. Squeeze film dampers are essentially hydrodynamic bearings which contain the ball bearings housings of ball-bearings supported shafts. Consequently, the oil film within the SFD are influenced only by the precession and nutation of the shaft, that is the flow of the oil within the damper is not directly influenced by the spin of the rotor. However, in the classical theory, the flow in the thin film is also governed by the Reynolds equation. In this paper, some of the limits of the classical theory of the SFD are discussed and theoretical and experimental studies, which illustrate the ideas presented herein, are presented as well. The orbits of an unbalanced rotor that is supported by a ...

Science.gov (United States)

This report summarizes the results of an expert-opinion elicitation activity designed to qualitatively assess the status and capabilities of currently available computer codes and models for accident analysis and reactor safety calculations of advanced sodium fast reactors, and identify important gaps. The twelve-member panel consisted of representatives from five U.S. National Laboratories (SNL, ANL, INL, ORNL, and BNL), the University of Wisconsin, the KAERI, the JAEA, and the CEA. The major portion of this elicitation activity occurred during a two-day meeting held on Aug. 10-11, 2010 at Argonne National Laboratory. There were two primary objectives of this work: (1) Identify computer codes currently available for SFR accident analysis and reactor safety calculations; and (2) Assess the status and capability of current US computer codes to adequately model the required accident scenarios and associated phenomena, and ...

Science.gov (United States)

Not Available

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A computer method that calculates tracheal cross-sectional area by compensating for partial volume averaging was developed and validated in a study with phantoms. The program was then used to determine the tracheal cross-sectional area of 30 normal children who ranged in age from four months to 18 years. CT-derived cross sections were correlated with age, height, weight, and body-surface area, and they were compared with findings of published clinical and post-mortem studies. CT cross-sectional areas ranged from 20 to 275 mm/sup 2/, varied by as much as 22% at the three different tracheal levels studied, and appeared to correlate most closely with body height. CT-derived tracheal cross-sectional areas are quite similar to those in published reports of postmortem and clinical studies. Measurements of tracheal cross section by CT may prove useful in quantitating tracheal compromise by intrinsic or extrinsic causes.

Science.gov (United States)

We report results of measurements and analysis of the heat capacity of MnSi. The measurements included data collection at a magnetic field of 4T, which suppresses strongly the longitudinal spin fluctuations and the phase transition. To analyze the experimental data, calculations of the phonon spectrum and phonon density of states in MnSi were performed. Inelastic neutron scattering with a polycrystalline sample of MnSi was used to validate the computational results. The combination of the experimental and theoretical data turned out to be decisive in revealing some hidden features of the thermal excitations in MnSi. In particular, the analysis of the available data led conclusively to the existence of a negative contribution to the heat capacity and entropy in MnSi at T>Tc, implying that a specific spin ordering process did occur in the paramagnet phase of MnSi.

International Nuclear Information System (INIS)

In spite of the improved imaging techniques currently available, mortality for pancreatic cancer is still high, and pancreatics is often diagnosed only in its advanced stages. The authors investigated the value of different imaging techniques - i.e., US, CT, and ERCP - for an early diagnosis, when a more effective (curative?) treatment can be suggested. Fifty-six cases of pancreatic cancer and 36 cases of chronic pancreatitis were evaluated. The results indicate that ERCP, with the help of statistical methods, is superior to US and CT not only in evaluating early neoplastic or inflammatory lesions, but also for their differential diagnosis. In the letter case, ERCP can sometimes be used as a valid alternative to fine-needle aspiration biopsy.

International Nuclear Information System (INIS)

In this paper, a time-domain equivalent circuit method is applied to solve dispersion of coupled-cavity travelling-wave tube (CCTWT). First, the time-domain circuit equations of CCTWT coupled-cavity chain are deduced from the equivalent circuit model. Then, the equations are solved numerically by fourth-order Runge-Kutta method and a program CTTDCP is developed using MATLAB. Last, a L-band CCTWT is calculated using CTTDCP and the cavity pass-band of this tube is computed to be 1.08-1.48 GHz, which is consistent with the experimental results and the simulation results of electromagnetic code and demonstrates the validity of the time-domain equivalent circuit method. In addition, a new design method which uses the equivalent circuit method and electromagnetic simulation together to optimize the cold cavity characteristics of CCTWT is proposed. (authors)

International Nuclear Information System (INIS)

In this paper, numerical simulation of a concentric tube heat exchanger is presented to determine the convective heat transfer coefficient and friction factor in a smooth tube. Increasing the convective heat transfer coefficient can increase heat transfer rate in a concentric tube heat exchanger from a given tubular surface area. This can be achieved by using heat transfer augmentation devices. This work constitutes the initial phase of the numerical simulation of heat transfer from tubes employing augmentation devices, such as twisted tapes, wire-coil inserts, for heat transfer enhancement. A computational fluid dynamics (CFD) simulation tool was developed with CFX software and the results obtained from the simulations are validated with the empirical correlations for a smooth tube heat exchanger. The difficulties associated with the simulation of a heat exchanger augmented with wire-coil inserts are discussed. (author)

CERN Document Server

The LHCb experiment has chosen to use the SAM framework (Service Availability Monitoring Environment from EGEE-II) [1] make extensive tests of the LHCb environment at all the accessible grid resources. The availability and the proper definition of the local Computing and Storage Elements, user interfaces as well as the WLCG software environment are checked. The SAM framework is also used to pre-install the LHCb applications in the shared software area provided by each site. The deployment of the LHCb applications is based on a python tool developed inside the experiment. It is used for software management including incremental installation of interdependent packages and clean package removal. After the application software is installed a validation test of the whole MC chain is run. According to the results of the experiment specific SAM tests, the sites are (re)integrated into the LHCb production system managed by DIRAC [2]. The possibility of ...

British Library Electronic Table of Contents (United Kingdom)

A detailed chemical kinetic reaction mechanism is developed for primary reference fuel mixtures of n-hexadecane and 2,2,4,4,6,8,8-heptamethyl nonane for diesel cetane ratings. The mechanisms are constructed using existing rules for reaction pathways and rate expressions developed previously for the primary reference fuels for gasoline octane ratings, n-heptane and iso-octane. These reaction mechanisms are validated by comparisons between computed and experimental results for shock tube ignition and for oxidation under jet-stirred reactor conditions. The combined kinetic reaction mechanism contains the submechanisms for the primary reference fuels for diesel cetane ratings and submechanisms for the primary reference fuels for gasoline octane ratings, all in one integrated large kinetic reac...

International Nuclear Information System (INIS)

This paper describes the study of particles' dispersion in an isotropic turbulent flow. The particle's motion and the turbulent flow characteristics are calculated independently. While the particles' displacement is computed by the author's code, the flow is simulated with a commercial code : PowerFLOW. The particles and the flow are coupled through the relative velocity component of the aerodynamic force. When the simulated flow is turbulent, a turbulence regeneration model is used in order to get the flow instantaneous velocity. Validation of the method is done by comparing the particles' dispersion obtained with experimental results from literature and with the results calculated by FLUENT. Good accordance is found between numerical studies and experimental results. However, comparison between results of PowerFLOW coupled to the author's code and results from FLUENT shows differences when the particle's path goes through the turbulent ...

Energy Technology Data Exchange (ETDEWEB)

The excitation function of ({alpha},{ital xn}) reactions on {sup 191}Ir (abundance 37.3%) and on {sup 193}Ir (abundance 62.7%) has been measured for the 17--55 MeV alpha-particle bombarding energy range. The stacked foil activation technique and {gamma}-ray spectroscopy were used to determine the cross sections. The experimental data were compared with calculated values obtained by means of a geometry-dependent hybrid model. The initial exciton number {ital n}{sub 0}=4 with {ital n}=2, {ital p}=2, and {ital h}=0 gives the best agreements with the presently measured results. To calculate the excitation function theoretically a computer code was used. This set of excitation functions provides a data basis for probing the validity of combined equilibrium and preequilibrium reaction models in a considerable energy range.

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The Stockpile Stewardship Program (SSP) is a single, highly integrated technical program for maintaining the safety and reliability of the U.S. nuclear stockpile. The SSP uses past nuclear test data along with current and future nonnuclear test data, computational modeling and simulation, and experimental facilities to advance understanding of nuclear weapons. It includes stockpile surveillance, experimental research, development and engineering programs, and an appropriately scaled production capability to support stockpile requirements. This integrated national program requires the continued use of current facilities and programs along with new experimental facilities and computational enhancements to support these programs. The Advanced Simulation and Computing Program (ASC)1 is a cornerstone of the SSP, providing simulation capabilities and computational resources to support the annual stockpile ...

International Nuclear Information System (INIS)

The implementation of wind energy conversion systems in the built environment renewed the interest and the research on Vertical Axis Wind Turbines (VAWT), which in this application present several advantages over Horizontal Axis Wind Turbines (HAWT). The VAWT has an inherent unsteady aerodynamic behavior due to the variation of angle of attack with the angle of rotation, perceived velocity and consequentially Reynolds number. The phenomenon of dynamic stall is then an intrinsic effect of the operation of a Vertical Axis Wind Turbine at low tip speed ratios, having a significant impact in both loads and power. The complexity of the unsteady aerodynamics of the VAWT makes it extremely attractive to be analyzed using Computational Fluid Dynamics (CFD) models, where an approximation of the continuity and momentum equations of the Navier-Stokes equations set is solved. The complexity of the problem and the need for new design approaches for VAWT for the built ...

Energy Technology Data Exchange (ETDEWEB)

In this work, a comprehensive model including heat transfer, fluid flow and solidification was used to evaluate the performance of a novel delivery system for a single-belt steel casting process. This near-net-shape casting, although still in development, is one of the most promising routes for casting of low-carbon steel in large scale. This paper focuses on the performance of a low-Re {kappa}-{epsilon} model that was employed to simulate the three-dimensional turbulent flows fully-coupled with heat transfer and macroscopic solidification. Simulations were run for the intended conditions of caster operation, and the results obtained with the {kappa}-{epsilon} were compared with the results obtained with an ad hoc viscosity model, where the molecular viscosity was boosted 100 times, uniformly throughout the computational domain. A semi-analytical solution was employed for validating the models and the results showed that the ad hoc viscosity ...

Science.gov (United States)

This dissertation reports on the application of numerical optimization techniques as applied to fuel cell simulation and design. Due to the "multi-physics" inherent in a fuel cell, which results in a highly coupled and non-linear behavior, an experimental program to analyze and improve the performance of fuel cells is extremely difficult. This program applies new optimization techniques with computational methods from the field of aerospace engineering to the fuel cell design problem. After an overview of fuel cell history, importance, and classification, a mathematical model of solid oxide fuel cells (SOFC) is presented. The governing equations are discretized and solved with computational fluid dynamics (CFD) techniques including unstructured meshes, non-linear solution methods, numerical derivatives with complex variables, and sensitivity analysis with adjoint methods. Following the validation of the fuel cell model in ...

Science.gov (United States)

The Predictive Capability Maturity Model (PCMM) is a new model that can be used to assess the level of maturity of computational modeling and simulation (M&S) efforts. The development of the model is based on both the authors experience and their analysis of similar investigations in the past. The perspective taken in this report is one of judging the usefulness of a predictive capability that relies on the numerical solution to partial differential equations to better inform and improve decision making. The review of past investigations, such as the Software Engineering Institute's Capability Maturity Model Integration and the National Aeronautics and Space Administration and Department of Defense Technology Readiness Levels, indicates that a more restricted, more interpretable method is needed to assess the maturity of an M&S effort. The PCMM addresses six contributing elements to M&S: (1) representation and geometric fidelity, (2) physics ...

Energy Technology Data Exchange (ETDEWEB)

The piston bowl design is one of the most important factors that affect the air-fuel mixing and the subsequent combustion and pollutant formation processes in a direct-injection diesel engine. The bowl geometry and dimensions, such as the pip region, bowl lip area, and toroidal radius, are all known to have an effect on the in-cylinder mixing and combustion process. In order to understand better the effect of re-entrant geometry, three piston bowls with different toroidal radii and lip shapes were investigated using computational fluid dynamics engine modelling. KIVA3V with improved submodels was used to model the in-cylinder flows and combustion process, and it was validated on a high-speed direct-injection engine with a second-generation common-rail fuel injection system. The engine's performance, in-cylinder flow, and combustion, and emission characteristics were analysed at maximum power and maximum torque conditions and at ...

Energy Technology Data Exchange (ETDEWEB)

Aerodynamics play a critical role in the success of a competitive solar vehicle. In particular, the topics addressed in this paper are minimizing the drag forces acting on the car surface while providing an effective angle of solar exposure, ventilation, manoeuvring stability, maintenance accessibility, and component `functional duality`, while simultaneously maintaining stringent racing regulations. Starting with a conceptual design, modifications were analysed through a commercial, computational fluid dynamics (CFD) package in order to evaluate drag and lift characteristics. By visualizing wind tunnel flow as a means of support of the coded model, the computational design has been validated. Although the design of the George Washington University (GWU) solar car `Sunforce 1` was geared towards the November 1993 World Solar Challenge held in Australia, results of the fourth place finish in the US Sunrace `93 were used to ...

International Nuclear Information System (INIS)

The goal of this work is to present a systematic Monte Carlo validation study on the clinical implementation of the enhanced dynamic wedges (EDWs) into the Pinnacle"3 (Philips Medical Systems, Fitchburg, WI) treatment planning system (TPS) and QA procedures for patient plan verification treated with EDWs. Modeling of EDW beams in the Pinnacle"3 TPS, which employs a collapsed-cone convolution superposition (CCCS) dose model, was based on a combination of measured open-beam data and the 'Golden Segmented Treatment Table' (GSTT) provided by Varian for each photon beam energy. To validate EDW models, dose profiles of 6 and 10 MV photon beams from a Clinac 2100 C/D were measured in virtual water at depths from near-surface to 30 cm for a wide range of field sizes and wedge angles using the Profiler 2 (Sun Nuclear Corporation, Melbourne, FL) diode array system. The EDW output factors (EDWOFs) for square fields from 4 to 20 cm wide were measured in ...

UK PubMed Central (United Kingdom)

ObjectiveIn the context of the importance of valid self-report measures to research and evidence-based practice in social work, an argument-based approach to validity...Full Text Available

Science.gov (United States)

... VALIDATING NETWORK SECURITY POLICIES VIA STATIC ANALYSIS OF ROUTER ACL CONFIGURATION by Eric Gregory Wen Wei Wong ...

Energy Technology Data Exchange (ETDEWEB)

This work reports an alternative methodology for the linear attenuation coefficient determination ({mu} {rho}) of irregular form samples, in such a way that is not necessary to consider the sample thickness. With this methodology, indigenous archaeological ceramics fragments from the region of Londrina, north of Parana, were studied. These ceramics fragments belong to the Kaingaing and Tupiguarani traditions. The equation for the {mu} {rho} determination employing the two mean method was obtained and it was used for {mu} {rho} determination by the gamma ray beam attenuation if immersed ceramics, by turns, in two different means with known linear attenuation coefficient. By the other side, {mu} theoretical value was determined with the XCOM computer code. This code uses as input the ceramics chemistry composition and provides an energy versus mass attenuation coefficient table. In order to validate the two mean method ...

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During the first 18 months of this project, four experimental subtasks were to have begun but only one of these was to have been completed. Additionally, five modeling subtasks were scheduled to begin, four of which were to have been completed. We are on schedule for all but one of these subtasks. All four experimental tasks are progressing on schedule. Initial durability tests were completed. The conclusions drawn from this first round of durability tests are being used to design the next set of tests. Initial baseline engine data were acquired and showed that the engine selected for this task behaves as hoped. However, the dyno controller is inadequate. The engine will be moved to another dyno during the near future. The modeling tasks are also progressing well. A model for the dynamic response of the ignition circuit was developed and validated. Two technical papers resulting from this model were submitted for publication. Development of a model for the railplug ...

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Heat fusion is the most common joining method for polyethylene gas distribution piping. Butt fusion was studied with the intent of relating the quality of the joint to the joining conditions. A semi-empirical approach was used. The thermofluid consequences of joining conditions such as heater temperature, heating time and joining parameter were calculated using a computer model. The model was validated by instrumented tests. The strength of the joints was gauged by destructive mechanical testing. Tensile and tensile impact tests were used. Over 150 joints were fabricated using four different polyethylene resins. Most of the data are given in GRI Report No. 88/0276.2 -- Volume 2: Technical Reference on Butt Heat Fusion Joining of Polyethylene Gas Pipes. A parameter, termed the Joining Parameter, was found to characterize the joining conditions. Of the mechanical tests parameters, the impact energy was found to have the best correlation with the ...

Energy Technology Data Exchange (ETDEWEB)

Validation of nuclear power reactor signals is often performed by comparing signal prototypes with the actual reactor signals. The signal prototypes are often computed based on empirical data. The implementation of an estimation algorithm which can make predictions on limited data is an important issue. A new machine learning algorithm called support vector machines (SVMS) recently developed by Vladimir Vapnik and his coworkers enables a high level of generalization with finite high-dimensional data. The improved generalization in comparison with standard methods like neural networks is due mainly to the following characteristics of the method. The input data space is transformed into a high-dimensional feature space using a kernel function, and the learning problem is formulated as a convex quadratic programming problem with a unique solution. In this paper the authors have applied the SVM method for data-based state estimation in nuclear ...

Science.gov (United States)

Operating PWR units in the USA have experienced very severe corrosion of the tube support plate at the crevice between the tube and the support. This results in distortion of the plate and crushing of the tube (denting). The first task of this project required that currently available computational methods to estimate the pH attained by concentrating boiler water under various fault conditions such as condenser leakage of river waters and faulty operation of condensate polishing plant. Particular attention has been paid to systems in which sulfate predominates. In the second task, the mechanisms are discussed by which solutions become concentrated in porous deposits on a boiling heat transfer surface. It is concluded that more experimental data are needed to test the validity of existing models. High solution concentrations in the deposit may occur at a heat flux close to the critical value for drying out the base of the deposit. The pore to ...

Energy Technology Data Exchange (ETDEWEB)

A computer model of cryogenic system for storing solid antimatter is used to explore the radiative cooling-power requirements for long-term antimatter storage. If vacuum-chamber pressures as low as 10 to -18th power torr can be reached, and the rest of the large set of assumptions is valid, milligram quantities of solid antimatter could be stored indefinitely at 1.5 K using cooling powers of less than a microwatt. Many of the assumptions made are problematic and need verification, as they could potentially change the results greatly. The system modeled is a sphere of solid anti-parahydrogen at 1.5 K or below levitated in a spherical cryogenic vacuum chamber. The free matter gas in the chamber is assumed to be molecular hydrogen, and sublimation of both matter and antimatter is assumed to be negligible. The antihydrogen is assumed to be in thermal equilibrium, although annihilation-energy deposition is localized and hydrogen's ...

Energy Technology Data Exchange (ETDEWEB)

Biodiesel made from vegetable oil is among the most desirable of renewable energy sources because it can be a substitute for diesel oil. However, biodiesel from soybean or corn can be confronted with a food crisis. Microalgae is a new biodiesel source which contains high oil lipids with a high growth rate, and which also offers value-added products from the residue, such as cosmetics, health functional food or pharmaceuticals. Microalgae are best cultivated in photo-bioreactors (PBRs) where light, nutrients, carbon dioxide and temperature can be controlled. Despite the current availability of PBRs, only a few can be practically used for mass production. Computational fluid dynamics (CFD) was used in this study to design an optimum bubble-column PBR for mass production of microalgae. Multi-phase models including bubble movement, meshes and time step independent tests were considered to develop the 3-dimensional CFD model. Particle Image Velocimetry (PIV) tests were ...

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The two-phase heat-transfer and pressure-drop characteristics of offset-strip-fin heat-exchanger geometries are examined using both experimental and analytical modeling techniques. Newly-obtained boiling-flow heat-transfer data are presented for two large-scale offset fin geometries at low-to-moderate wall-superheat conditions. Data for which nucleate boiling appeared to be completely suppressed were analyzed together with similar results for other offset fin surfaces to study the effects of channel dimensions on the convective evaporation component of the local heat transfer coefficient. Although these data were found to be well correlated in terms of modified forms of the F and Martinelli parameters used in previous studies of round-tube flows, a single F-factor correlation valid for all combinations of fin and channel dimensions did not appear to exist. The two-phase pressure-drop characteristics of offset-fin surfaces were found to be much different than those ...

Science.gov (United States)

The Heavy Water Reactor Facility (HWRF), as part of the defense-in-depth philosophy to mitigate the effect of design-basis and severe accidents, is equipped with a passive containment cooling system (PCCS). The function of the PCCS is to provide a safety-grade path to the ultimate heat sink for the removal of the reactor coolant system sensible heat and core decay heat. Ambient air enters an annular space between the steel containment shell and the surrounding concrete shield building through inlets in the shield building wall, is heated via natural convection, rises, and exits the building through a chimney located above the containment dome. A test program is in place to access parameters important to the effective operation of the PCCS. This paper focuses on the large-scale tests (LSTs). The objectives of these tests are as follows: (1) demonstrate natural circulation cooling with more prototypic cylinder and dome surface area ratios than were available in the small-scale test; (2) ...

International Nuclear Information System (INIS)

Many types of pipe whip restraints are installed to protect the structural components from the anticipated pipe whip phenomena of high energy lines in nuclear power plants. It is necessary to investigate these phenomena accurately in order to design the pipe whip restraints properly and/or to evaluate the acceptability of the pipe whip restraint design. Various research programs have been conducted in many countries to develop analytical methods and to verify the validity of the methods. In this study, various types of finite elements in ANSYS, the general purpose finite element computer grogram, was used to simulate the postulated pipe whips to obtain impact loads and the calculted results were compared with the specific experimental results from the sample pipe whip test for the U-chaped pipe whip restraints. Some calculational models, having the gap element or the spring element between the pipe whip restraint and the pipe line, give ...

Energy Technology Data Exchange (ETDEWEB)

In this report, we have examined some of the fundamental mechanisms expected to be at work during mobilization of the waste within the double-shell tanks at Hanford. The motivation stems from the idea that in order to properly apply correlations derived from scaled tests, one would have to ensure that appropriate scaling laws are utilized. Further, in the process of delineating the controlling mechanisms during mobilization, the currently used computational codes are being validated and strengthened based on these findings. Experiments were performed at 1/50-scale, different from what had been performed in the previous fiscal years (i.e., 1/12- and 1/25-scale). It was anticipated that if the current empirical correlations are to work, they should be scale invariant. The current results showed that linear scaling between the 1/25-scale and 1/50-scale correlations do not work well. Several mechanisms were examined in the scaled tests which might ...

International Nuclear Information System (INIS)

Further to a cost-benefit analysis of the various medium-term and long-term and H.L.W. storage possibilities, C.E.A. (French Atomic Energy Commission) and S.G.N. decided to develop an original dry storage process with natural convection cooling that offers many advantages: cut in the total investment and operating costs; high operating safety; natural convection cooling; existence of two containment barriers irrespective of the assumed clad conditions; flexible, modular and compact design. The process was first implemented in the so-called CASCAD Cadarache Facility (vault-type facility) constructed in Cadarache mainly to store fuel from Brennilis heavy water reactor. For the purpose, a large program was set up to develop and validate computer codes, in particular with the use of mockups. On the request of many clients, and owing to the outstanding operating results of the CASCAD Cadarache Facility, SGN was brought to adapt the process to the ...

Science.gov (United States)

Seasonal Allergic Rhinitis

Norwegian Open Research Archives (NORA)

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The relative abundance and variation of Cr, Co, Cd and Pb in Ascophyllum nodosum and intertidal surface sediments from six locations around the coast were assessed over six seasons. Higher Cd and Pb levels in Galway Docks and Cork Harbour were attributed to localised inputs of these metals from municipal and domestic waste, while at a reference site (Ballyconneely), high algal Cr concentrations were considered a function of geological setting rather than anthropogenic loading. Little seasonal variation was observed, with the exception of higher Co levels in plants in winter, associated with growth dynamics and increased fluvial inputs. In comparison with previously published data for metals in A. nodosum from the North Atlantic, with the exception of localised hot spots, the Irish coastline is still a relatively pristine environment. A. nodosum may be successfully and easily used as a biomonitor of metal contamination in coastal waters. - This paper provides ...

Energy Technology Data Exchange (ETDEWEB)

The impingement of a fluid jet onto a surface has broad applications across many industries. Within the UK nuclear industry, during the final stages of fuel reprocessing, impinging fluid jets are utilised to mobilise settled sludge material within storage tanks and ponds in preparation for transfer and ultimate immobilisation through vitrification. Despite the extensive applications of impinging jets within the nuclear and other industries, the study of two-phase, solid loaded, impinging jets is limited, and generally restricted to computational modelling. Surprisingly, very little fundamental understanding of the turbulence structure within such fluid flows through experimental investigation is found within the literature. The physical modelling of impinging jet systems could successfully serve to aid computer model validation, determine operating requirements, evaluate plant throughput requirements, optimise process ...

International Nuclear Information System (INIS)

Three-dimensional computer simulation and analyses of the horizontal steam generator thermal-hydraulics of the WWER 1000 nuclear power plant have been performed for 50% and 75% partial loads, 100% nominal load and 110% over-load. Presented results show water and steam mass flow rate vectors, steam void fraction spatial distribution, recirculation zones, swell level position, water mass inventory on the shell side, and other important thermal-hydraulic parameters. The simulations have been performed with the computer code 3D ANA, based on the 'two-fluid' model approach. Steam-water interface transport processes, as well as tube bundle flow resistance, energy transfer, and steam generation within tube bundles are modelled with "closure laws". Applied approach implies non-equilibrium thermal and flow conditions. The model is solved by the control volume procedure, which has been extended in order to take into account the 3D flow of liquid and gas ...

International Nuclear Information System (INIS)

A numerical study of a natural convection in a rectangular cavity with the low-Reynolds-number differential stress and flux model is presented. The primary emphasis of the study is placed on the investigation of the accuracy and numerical stability of the low-Reynolds-number differential stress and flux model for a natural convection problem. The turbulence model considered in the study is that developed by Peeters and Henkes (1992) and further refined by Dol and Hanjalic (2001), and this model is applied to the prediction of a natural convection in a rectangular cavity together with the two-layer model, the shear stress transport model and the time-scale bound #upsilon#"2-f model, all with an algebraic heat flux model. The computed results are compared with the experimental data commonly used for the validation of the turbulence models. It is shown that the low-Reynolds-number differential stress and flux model predicts well the mean velocity ...

Science.gov (United States)

Not Available

International Nuclear Information System (INIS)

Full text of publication follows: The TUV NORD e.V. is an independent Technical Support Organisation (TSO) performing safety assessments in almost every field of technology. In nuclear safety the TUV can look back on more than 40 years of experience. In the last years in Germany PWR safety analyses were focussed on boron dilution events with the potential of reactivity transients. The possibility of coolant with a low boron concentration collected in localized areas of the reactor coolant system (RCS) can be caused by injection of coolant with less boron content from interfacing systems (external dilution) as well as separation of borated reactor coolant into highly concentrated and diluted fractions (inherent dilution). Inherent dilution can e.g. occur after reflux-condenser heat transfer after a small break loss of coolant accident (SBLOCA) with a limited operability of the emergency core cooling (ECC) systems. The TUV Nord e.V. was charged by German supervisory authorities with the ...

UK PubMed Central (United Kingdom)

The identification and validation of biomarkers for diagnosing Alzheimer's disease (AD) and other forms of dementia are increasingly important. To date, ELISA measurement of β-amyloid(1–42),...Full Text Available

International Nuclear Information System (INIS)

According to the present concept, the low and intermediate level wastes generated during the Cernavoda NPP operation will be disposed in a near surface repository. The Saligny site, placed in the NPP protected area, has been proposed for their disposal. Geologically, the main components of this site are the quaternary loess, the Precambrian and Pre-quaternary clays, the Eocene and Barremian limestone. Hydrologically, the site can be divided into a vadose zone down to 45-50 m and three distinct aquifers, two of them in the limestone beds and the third in the lenses of sand and limestone existing in the pre-quaternary clay layer. A large research program for site characterization was initiated in 1996. At present, the site characteristics requested for safety analysis have been experimentally measured on soil samples or calculated by different computer programs. Hundreds of experimental values of the density, porosity, hydraulic conductivity, soil-water retention, ...

Science.gov (United States)

... It is recommended that the drawings be validated in accordance with NAVAIRINST 4333.10 and the data package, Appendix A, be used for ...

Science.gov (United States)

... During operations, the system successfully treated Phosgene (CG), chloropicrin (PS), a smoke-generating formulation based on hexachloroethane ...

Energy Technology Data Exchange (ETDEWEB)

Quantum computers hold great promises for the future of computation. In this paper, this new kind of computing device is presented, together with a short survey of the status of research in this field. The principal algorithms are introduced, with an emphasis on the applications of quantum computing to physics. Experimental implementations are also briefly discussed.

Energy Technology Data Exchange (ETDEWEB)

In this work theoretical investigations are carried out for cooling systems, which are used in fuel cell vehicles. This work focuses mainly on the capability of increasing the heat rejection rate by using new alternative cooling systems and by improving the conventional cooling system. Fuel cell vehicles have a higher demand of heat rejection to the ambient than comparable vehicles with combustion engine. The performance of conventional liquid cooling systems, especially at high loads and high ambient temperatures, is often not sufficient anymore. Hence, cooling systems with improved performance are necessary for fuel cell vehicles. The investigations in this work are based on DaimlerChrysler's ''A-Class'' having a PEM-Fuel Cell system integrated. Specific computational models are developed for radiators and condensers to evaluate the performance of different cooling concepts. The models are ...

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In this study we tried to develop the long-range transport system and find the way to prevent from the radiological emergency risk. For the study, meteorological forecast system in Korea Meteorological Administration is investigated. Numerical simulation is also carried out by the long-range transport model and Vis-5D. We surveyed the emergency preparedness for nuclear accidents which were ARAC in USA, RODOS in Europe and WSPEED in Japan and then investigated the processing of medium- and long-range atmospheric diffusion modeling system. We also studied on the application of KMA/NWPD model which are GDAPS and RDAPS. In the future, it is necessary to produce to the high resolution meteorological data from KMA/NWPD for the development of medium- and long-range atmospheric diffusion modeling system and construct the integrated system for data processing in real time. It was simulated by using micro-scale meteorological field applying wind field model with high resolution. Although it have ...

International Nuclear Information System (INIS)

The FFTF is a 400-MWt sodium-cooled fast neutron flux test reactor located on the US government-owned Hanford Site in southeastern Washington state. The reactor is operated for the US Department of Energy by the Westinghouse Hanford Company. Since FFTF started routine operation in 1982, the commercially fabricated driver fuel has performed flawlessly to well beyond the design goal peak burnup of 80 MWd/kgM. The core average discharge exposure is now some 60% beyond the original design expectations and attests to the ruggedness and reliability of the mixed oxide fuel system. In Cycle 9 sixteen long-life assemblies were installed to begin the irradiation of mixed oxides in the advanced low-swelling alloy HT-9 as the Core Demonstration Experiment (CDE). Operation of the plant from initial startup testing to ten cycles of operation has confirmed that the nuclear characteristics are well within the design predictions, and all parameters have remained inside the operating envelope defined by ...

Energy Technology Data Exchange (ETDEWEB)

The authors are developing MP-TOUGH2 for exploiting massively parallel computers. The goals of this effort are to (1) create a data-parallel subsurface transport code for solving larger problems than currently practical on workstations, (2) write portable code that can take advantage of scalability to run on machines with more processors, and (3) minimize the necessity for additional validation and verification of the resulting code. The initial strategy they have followed is to focus on optimizing the generic and time-consuming task of linear equation solution while leaving the bulk of TOUGH2 unmodified. In so doing, they have implemented a massively parallel direct solver (MPDS) that takes advantage of the banded structure of TOUGH2 Jacobian matrices. The authors have compared timings of the iterative conjugate gradient solvers DSLUBC, DSLUCS, and DSLUGM written in Fortran77 for the front end with the MPDS which uses the data parallel unit. ...

International Nuclear Information System (INIS)

Full text: A Large Sample Neutron Activation Analysis (LSNAA) facility is under development at GRR-1 research reactor, NCSR 'Demokritos'. The LSNAA facility design incorporates sample irradiation in the reactor's graphite thermal neutron column and subsequent measurement of the activity induced at a gamma spectroscopy system with gamma ray transmission measurement options included. Monte Carlo neutron and photon transport code MCNP-4C was used to model the facility. Appropriate correction factors accounting for neutron field perturbation during sample irradiation, high purity germanium detector efficiency for the volume source and gamma ray self-absorption within the sample itself were derived. The results of the computations were experimentally verified by activation foil measurements for a set of known materials and a range of sample sizes extending up to 10 litters. Moreover, the special issue of large sample analysis of non-homogeneous samples is examined and ...

International Nuclear Information System (INIS)

Important steady-state thermohydraulic parameters of the TRIGA research reactor operating under natural convection mode of coolant flow were investigated using NCTRIGA computer code. Neutronic parameters used in preparing the input of NCTRIGA were taken from the analysis performed by 3-D Monte Carlo code MCNP4C. Benchmarking of the NCTRIGA calculated results were performed against the experimental data measured by the thermocouples in the instrumented fuel element (IFE) during the steady state operation of the reactor under natural convection mode of coolant flow. Various thermohydraulic parameters like the coolant velocity, flow rate and mass flow rate were generated for the hot channel as well as for the two channels comprising instrumented fuels. Calculated peak fuel temperatures at different power levels were compared with the measured values and also with the calculations performed by PARET code. Axial temperature profile at the fuel centreline, fuel surface ...

Energy Technology Data Exchange (ETDEWEB)

An axisymmetric plasma screw pinch is an axisymmetric column of ionized gaseous plasma radially confined by forces from axial and azimuthal currents driven in the plasma and its surroundings. This dissertation is a contribution to detailed, high resolution computer simulation of dynamic plasma screw pinches in 2-d {ital rz}-coordinates. The simulation algorithm combines electron fluid and particle-in-cell (PIC) ion models to represent the plasma in a hybrid fashion. The plasma is assumed to be quasineutral; along with the Darwin approximation to the Maxwell equations, this implies application of Ampere`s law without displacement current. Electron inertia is assumed negligible so that advective terms in the electron momentum equation are ignored. Electrons and ions have separate scalar temperatures, and a scalar plasma electrical resistivity is assumed. Altemating-direction-implicit (ADI) methods are used to advance the electron fluid drift velocity and the magnetic ...

International Nuclear Information System (INIS)

DECOVALEX II project started in November 1995 as a continuation of the DECOVALEX I project, which was completed at the end of 1994. The project was initiated by recognizing the fact that a proper evaluation of the current capacities of numerical modelling of the coupled T-H-M processes in fractured media is needed not only for small scale, well controlled laboratory test cases such as those studied in DECOVALEX I, but also for less characterised, more complex and realistic in-situ experiments. This will contribute to validation and confidence building in the current mathematical models, numerical methods and computer codes. Four tasks were defined in the DECOVALEX II project: TASK 1 - numerical study of the RCF3 pumping test and shaft excavation at Sellafield by Nirex, UK; TASK 2 - numerical study of the in-situ T-H-M experiments at Kamaishi Mine by PNC, Japan; TASK 3 - review of current state-of-the-art of rock joint research and TASK 4 - ...

Energy Technology Data Exchange (ETDEWEB)

Organic Rankine cycles (ORC) have unique properties that are well suited to solar power generation. In this work design and performance calculations are performed using MatLab/SimuLink computational environment. The cycle consists of thermal solar collectors (Flat Plate Solar Collector (FPC), or Parabolic Trough Collector (PTC), or Compound Parabolic Concentrator (CPC)) for heat input, expansion turbine for work output, condenser unit for heat rejection, pump unit, and Reverse Osmosis (RO) unit. Reverse osmosis unit specifications used in this work is based on Sharm El-Shiekh RO desalination plant. Different working fluids such as: butane, isobutane, propane, R134a, R152a, R245ca, and R245fa are examined for FPC. R113, R123, hexane, and pentane are investigated for CPC. Dodecane, nonane, octane, and toluene are allocated for PTC. The proposed process units are modeled and show a good validity with literatures. Exergy and cost analysis are ...

International Nuclear Information System (INIS)

In the future, the demand for energy is predicted to grow and more countries plan to utilize nuclear energy as their source of electric energy. This gives rise to many important issues connected to nuclear energy, such as finding methods that can verify that the spent nuclear fuel has been handled safely and used in ordinary power producing cycles as stated by the operators. Gamma ray spectroscopy is one method used for identification and verification of spent nuclear fuel. In the specific gamma ray spectroscopy method called gamma scanning the gamma radiation from the fission products Cs-137, Cs-134 and Eu-154 are measured in a spent fuel assembly. From the results, conclusions can be drawn about the fuels characteristics. This degree project examines the possibilities of using alternative measuring approaches when using the gamma scanning method. The focus is on examining how to increase the quality of the measured data. How to decrease the measuring time as compared with the present ...

Science.gov (United States)

Recent work on the aerodynamics of flapping flight reveals fundamental differences in the mechanisms of aerodynamic force generation between fixed and flapping wings. When fixed wings translate at high angles of attack, they periodically generate and shed leading and trailing edge vortices as reflected in their fluctuating aerodynamic force traces and associated flow visualization. In contrast, wings flapping at high angles of attack generate stable leading edge vorticity, which persists throughout the duration of the stroke and enhances mean aerodynamic forces. Here, we show that aerodynamic forces can be controlled by altering the trailing edge flexibility of a flapping wing. We used a dynamically scaled mechanical model of flapping flight (Re approximately 2000) to measure the aerodynamic forces on flapping wings of variable flexural stiffness (EI). For low to medium angles of attack, as flexibility of the wing increases, its ability to generate aerodynamic forces decreases ...

Energy Technology Data Exchange (ETDEWEB)

Detailed chemical kinetic reaction mechanisms have been developed to describe the pyrolysis and oxidation of nine n-alkanes larger than n-heptane, including n-octane (n-C{sub 8}H{sub 18}), n-nonane (n-C{sub 9}H{sub 20}), n-decane (n-C{sub 10}H{sub 22}), n-undecane (n-C{sub 11}H{sub 24}), n-dodecane (n-C{sub 12}H{sub 26}), n-tridecane (n-C{sub 13}H{sub 28}), n-tetradecane (n-C{sub 14}H{sub 30}), n-pentadecane (n-C{sub 15}H{sub 32}), and n-hexadecane (n-C{sub 16}H{sub 34}). These mechanisms include both high temperature and low temperature reaction pathways. The mechanisms are based on our previous mechanisms for the primary reference fuels n-heptane and iso-octane, using the reaction class mechanism construction first developed for n-heptane. Individual reaction class rules are as simple as possible in order to focus on the parallelism between all of the n-alkane fuels included in the mechanisms, and these mechanisms will be refined further in the future to incorporate greater levels of ...

UK PubMed Central (United Kingdom)

We present interactive computer programs for the analysis of nucleic acid sequences. In order to handle these programs, minimum computer experience is sufficient. The nucleotide sequence of the human...Full Text Available

USGS Gallery

USGS geologists Peter Triezenberg and William Danforth sit with WHOI/LDEO Computer Technician Tom Bolmer in the Healy computer lab. This was during a scientific expedition to map the Arctic seafloor....

Science.gov (United States)

In view of the findings that several Kunitz-type protein inhibitors suppress tumor invasion and metastasis, the aim of the present study is to explore whether Bungarus multicinctus protease inhibitor-like protein-2 (PILP-2) and PILP-3 exhibit anti-tumor activity. Although approximately 28% of amino acid substitutions occurred between PILP-2 and PILP-3, molecular modeling suggested that PILP-2 and PILP-3 shared similar folded structures. Unlike PILP-2, PILP-3 showed a notable activity in abolishing migration and invasion of human neuroblastoma SK-N-SH cells. The ability of PILP-3 to inhibit matrix metalloprotease-2 (MMP-2) activity was higher than that of PILP-2. Pull-down assay revealed protein-protein interaction between PILP-3 and MMP-2. In contrast to mutation on N-terminal region, replacement of amino acids at C-terminus attenuated notably the ability of PILP-3 to inhibit cell invasion, cell migration and MMP-2 activity as well as the binding capability of PILP-3 with MMP-2. ...

Science.gov (United States)

Not Available

Energy Technology Data Exchange (ETDEWEB)

A new model for computations is considered which combines the quantum computer with the chaotic dynamics amplifier, based on the logistic map. We discuss the satisfiability problem and argue that the problem can, in principle, be solved in polynomial time if one uses the new model for computations.

KoreaScience (Korea)

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Energy Technology Data Exchange (ETDEWEB)

No abstract prepared.

Science.gov (United States)

PMID:21901085

DEFF Research Database (Denmark)

Background:The validity of dementia diagnoses in the Danish nationwide hospital registers was evaluated to determine the value of these registers in epidemiological research about dementia. Methods: Two hundred patients were randomly selected from 4,682 patients registered for the first time with a dementia diagnosis in the last 6 months of 2003. The patients' medical journals were reviewed to evaluate if they fulfilled ICD-10 and/or DSM-IV criteria for dementia and specific dementia subtypes. The patients who were still alive in 2006 were invited to an interview. Results: One hundred and ninety-seven journals were available for review and 51 patients were interviewed. A registered diagnosis of dementia was found to be correct in 169 (85.8%) cases. Regarding dementia subtypes, the degree of agreement between the registers and the results of the validating process was low with a kappa of 0.36 (95% CI 0.24-0.48). Conclusion: The ...

Science.gov (United States)

... Accession Number : ADA100385. Title : Rubin's Empirical Bayes Computations are Not Useful for Law School Admissions - Comment,. ...

Science.gov (United States)

... Accession Number : ADA152970. Title : Optical Phenomena in Computer Vision,. Corporate Author : ROCHESTER UNIV ...

Science.gov (United States)

... Accession Number : ADA019663. Title : Depth Perception in Stereo Computer Vision. Descriptive Note : Technical rept.,. ...

Science.gov (United States)

Page 1. Adaptive system and method for responding to computer network security attacks Abstract A dynamic network security ...

Energy Technology Data Exchange (ETDEWEB)

Waveform correlation detectors compare a signal template with successive windows of a continuous data stream and report a detection when the correlation coefficient, or some comparable detection statistic, exceeds a specified threshold. Since correlation detectors exploit the fine structure of the full waveform, they are exquisitely sensitive when compared to power (STA/LTA) detectors. The drawback of correlation detectors is that they require complete knowledge of the signal to be detected, which limits such methods to instances of seismicity in which a very similar signal has already been observed by every station used. Such instances include earthquake swarms, aftershock sequences, repeating industrial seismicity, and many other forms of controlled explosions. The reduction in the detection threshold is even greater when the techniques are applied to arrays since stacking can be performed on the individual channel correlation traces to achieve significant array gain. In previous ...

Science.gov (United States)

C. Learning Curve. The learning curve concept has long been recognized and ...... F4. TERMIA. S - STATION EQUIPMENT. V - VLBI VALIDATION EQUIPMENT ...

UK PubMed Central (United Kingdom)

BACKGROUND:In adults, it is well known that high levels of pain catastrophizing are related to increased pain and disability as well as to heightened anxiety and depression. However,...Full Text Available

UK PubMed Central (United Kingdom)

SynopsisAttention-deficit / hyperactivity disorder (ADHD) is a valid and impairing psychological disorder that persists into adulthood in a majority of cases and is associated...Full Text Available

CERN Document Server

Inferring cluster structure in microarray datasets is a fundamental task for the -omic sciences. A fundamental question in Statistics, Data Analysis and Classification, is the prediction of the number of clusters in a dataset, usually established via internal validation measures. Despite the wealth of internal measures available in the literature, new ones have been recently proposed, some of them specifically for microarray data. In this dissertation, a study of internal validation measures is given, paying particular attention to the stability based ones. Indeed, this class of measures is particularly prominent and promising in order to have a reliable estimate the number of clusters in a dataset. For those measures, a new general algorithmic paradigm is proposed here that highlights the richness of measures in this class and accounts for the ones already available in the literature. Moreover, some of the most representative ...

UK PubMed Central (United Kingdom)

BackgroundAdequate pain assessment is critical for evaluating the efficacy of analgesic treatment in clinical practice and during the development of new therapies. Yet the currently...Full Text Available

International Nuclear Information System (INIS)

Environmental computer science is a new partial discipline of applied computer science, which makes use of methods and techniques of information processing in environmental protection. Thanks to the inter-disciplinary nature of environmental problems, computer science acts as a mediator between numerous disciplines and institutions in this sector. The handbook reflects the broad spectrum of state-of-the art environmental computer science. The following important subjects are dealt with: Environmental databases and information systems, environmental monitoring, modelling and simulation, visualization of environmental data and knowledge-based systems in the environmental sector. (orig.).

Energy Technology Data Exchange (ETDEWEB)

This interim technical report presented a summary of results obtained from Pit Lake models developed from different simulation models. The models were used to predict stratification in a hypothetical Pit Lake. Predictions were used to assess the hydrodynamic similarities and differences between the 2 models and to determine if the models would produce similar stratification profiles for the Pit Lakes to previous models. Results showed that the models produced similar results for both temperatures and salinities. The main difference between the RMA10 and CE-QUAL-W2 model used in a previous study was found to be run time. A sensitivity analysis of the RMA10 and CE-QUAL-W2 model predictions was completed to assess the effects of segmentation; time step; lake surface area; lake orientation; and model coefficients or parameters. Results showed that the selected time step and model segmentation were appropriate, as both led to modelling results that were stable. However, while the CE-QUAL-W2 ...

International Nuclear Information System (INIS)

Current methods to calculate dose distributions with organ motion can be broadly classified as 'dose convolution' and 'fluence convolution' methods. In the former, a static dose distribution is convolved with the probability distribution function (PDF) that characterizes the motion. However, artifacts are produced near the surface and around inhomogeneities because the method assumes shift invariance. Fluence convolution avoids these artifacts by convolving the PDF with the incident fluence instead of the patient dose. In this paper we present an alternative method that improves the accuracy, generality as well as the speed of dose calculation with organ motion. The algorithm starts by sampling an isocenter point from a parametrically defined space curve corresponding to the patient-specific motion trajectory. Then a photon is sampled in the linac head and propagated through the three-dimensional (3-D) collimator structure corresponding to a particular MLC segment chosen randomly from ...

British Library Electronic Table of Contents (United Kingdom)

The International Index of Erectile Function is a well-worded and psychometrically valid self-report questionnaire widely used as the standard for the evaluation of male sexual function. However, some conceptual and statistical problems arise when using the measure with men who are not sexually active. These problems are illustrated using 2 empirical examples, and the authors provide recommended solutions to further strengthen the efficacy and validity of this measure.

Energy Technology Data Exchange (ETDEWEB)

Quantum computers hold the promise of solving certain computational tasks much more efficiently than classical computers. We review recent experimental advances towards a quantum computer with trapped ions. In particular, various implementations of qubits, quantum gates and some key experiments are discussed. Furthermore, we review some implementations of quantum algorithms such as a deterministic teleportation of quantum information and an error correction scheme.

Wastenet

... - Climate Action Programme cloud computing, climaet change, carbon emissions, verdantix, cloud, it, computer cloud computing, climaet change, carbon emissions,...verdantix, cloud, it, computer GreenMedia.com AidForumOnline.org ClimateActionProgramme.org Search Climate Action... In partnership with the United Nations ...

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This contribution is intended to introduce the principles of quantum computing to those who always wanted to know about quantum computing but never dared to ask. (copyright 2007 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim) (orig.)

Energy Technology Data Exchange (ETDEWEB)

Following a brief description of the SSC, the computing needs are discussed for both the accelerator design and the experimentation. The computing power required is considerably beyond that being used at present facilities, and parallel processing is expected to play an important role in supplying these needs.

Wastenet

...Electronic equipment,Embedded computer systems,Technology & Engineering,Automotive - General,COMPUTERS / Computer Engineering,TECHNOLOGY & ENGINEERING / Electronics ...

CERN Document Server

We discuss models of computing that are beyond classical. The primary motivation is to unearth the cause of nonclassical advantages in computation. Completeness results from computational complexity theory lead to the identification of very disparate problems, and offer a kaleidoscopic view into the realm of quantum enhancements in computation. Emphasis is placed on the `power of one qubit' model, and the boundary between quantum and classical correlations as delineated by quantum discord. A recent result by Eastin on the role of this boundary in the efficient classical simulation of quantum computation is discussed. Perceived drawbacks in the interpretation of quantum discord as a relevant certificate of quantum enhancements are addressed.

Energy Technology Data Exchange (ETDEWEB)

The role of computers has become increasingly important for oil and gas field research and operations support. Today, the computer network is an integral part of the increasingly complex computing environment that exists in many companies. Computer networks allow users to efficiently share information, software, and hardware to support critical global communication needs. Because users are able to share software and hardware, the use of computer networks can also result in significant cost savings. This paper describes typical network loading and demand levels for shared software applications on a computer network that has been used for several years.

Science.gov (United States)

National Aeronautics and Space Administration. Issue 2. June 2010 this issue. Nebula: Cloud Computing p.1. Better Business with EA p.2 ...

Science.gov (United States)

... FL, April 18-20, 2006 Using Advanced Computer Vision Algorithms on Small Mobile Robots G. Koguta,F. Birchmoreb,E ...

Science.gov (United States)

The results of this research centered on the experimental studies of a single superconducting persistent current qubit, the implementation of type-II algorithms using these qubits, and the proposal for adiabatic quantum computing using these qubits. The m...

Science.gov (United States)

... exercises and biotechnology labs and didactic material. It includes sessions on computer and media ... computers, and learn how IPT activities and materials can help meet their curriculum objects ...

Energy Technology Data Exchange (ETDEWEB)

We survey results in lattice quantum chromodynamics from groups in the USQCD Collaboration. The main focus is on physics, but many aspects of the discussion are aimed at an audience of computational physicists.

Science.gov (United States)

Sep 1, 2011 ... 2005. Computer simulation modeling of recreation use: current status, case studies, and future directions. Gen. Tech. Rep. RMRS-GTR-143. ...

Energy Technology Data Exchange (ETDEWEB)

There is considerable interest in the use of silicon devices as qubits for quantum computing. The existence of nuclear spin in a silicon isotope and the complex band structure of silicon are unfavourable for this application of silicon devices. (viewpoint)

Science.gov (United States)

Explore security settings for home equipment, learn how to browse safely and securely, and keep your computer up to date and secure. Explore different account ...

CERN Multimedia

Speaking to thousands of attendees at Oracle's customer and partner conference, Chairman and CEO Larry Ellison launched Oracle's Grid Computing initiative (1/2 page).

Energy Technology Data Exchange (ETDEWEB)

A case of intrathoracic lipoma in a child is presented. The diagnosis was made before operation by means of computer-assisted tomography, a non-interventional procedure.

USGS Gallery

USGS scientists Ellyn Montgomery and William Danforth discuss incoming data in a computer lab on U.S. Coast Guard Cutter Healy. This was during a scientific expedition to map the Arctic seafloor....

Energy Technology Data Exchange (ETDEWEB)

138 unselected head tomographies of children by computer are reported and analysed. The major aspect stressed by the authors is the excellent precision of this radiological technique.

Science.gov (United States)

He said, I had heard of Cloud Computing when I was in grad school, but they had presentations on it at EclipseCon. I was sold that it was something that ...

Science.gov (United States)

Sep 1, 2011 ... Publication Information. Bookmark and Share. Title: Arc Habitat Suitability Index computer software. Author: Juntti, Thomas M.; Rumble, Mark A. ...

British Library Electronic Table of Contents (United Kingdom)

Two studies (N = 420) were conducted to develop and validate the instructional dissent scale (IDS) for use in the college classroom. Participants in study 1 were 210 students who completed the IDS pilot inventory which was subjected to an exploratory factor analysis yielding three distinct factors of dissent (i.e., expressive, rhetorical, vengeful). Concurrent validity support was provided as perceived teacher misbehaviors were associated positively with students' likelihood of engaging in dissent and students reported fewer learning outcomes when they dissented. Participants in study 2 were from a different sample of 210 students who completed the IDS along with measures of classroom justice and student challenge behavior. A confirmatory factor analysis provided support for the hypothesiz...

Science.gov (United States)

Sandia National Laboratories has erected a research oriented, 34- meter diameter, Darrieus vertical axis wind turbine near Bushland, Texas. This machine, designated the Sandia 34-m VAWT Test Bed, is equipped with a large array of strain gauges that have been placed at critical positions about the blades. This manuscript details a series of four-point bend experiments that were conducted to validate the output of the blade strain gauge circuits. The output of a particular gauge circuit is validated by comparing its output to equivalent gauge circuits (in this stress state) and to theoretical predictions. With only a few exceptions, the difference between measured and predicted strain values for a gauge circuit was found to be of the order of the estimated repeatability for the measurement system.

British Library Electronic Table of Contents (United Kingdom)

The aim of this work is the development and experimental validation of a detailed dynamic fuel cell model using the gPROMS modeling environment. The model is oriented towards optimization and control and it relies on material and energy balances as well as electrochemical equations including semi-empirical equations. For the experimental validation of the model a fully automated and integrated hydrogen fuel cell testing unit was used. The predictive power of the model has been compared with the data obtained during load change experiments. A sensitivity analysis has been employed to reveal the most critical empirical model parameters that should be estimated using a systematic estimation procedure. Model predictions are in good agreement with experimental data under a wide range of operati...

British Library Electronic Table of Contents (United Kingdom)

As part of the United States Department of Agricultures (USDA) National Food and Nutrient Analysis Program (NFNAP), food composition data for vitamin D in the USDA National Nutrient Database for Standard Reference are being updated and expanded, focusing on high priority foods and validated analytical methodology. A lack of certified reference materials and analytical methods validated for these key foods required the development of five matrix-specific control composite materials (CC) (canned salmon and vitamin D3 fortified cereal, orange juice, milk, and cheese). Each of six experienced laboratories (research and commercial) analyzed vitamin D3 in five subsamples of each CC in five separate analytical batches, with one subsample of each material in each run. Research laboratories perform...

Science.gov (United States)

Studies in our wound ballistics laboratory have shown that excellent healing can occur in complicated assault rifle wounds that are free of tension and well drained. A conservative approach to debridement and excision of tissue in uncomplicated extremity wounds may be a valid and resource-saving technique. PMID:2366941

UK PubMed Central (United Kingdom)

BackgroundStrategies to accurately identify the occurrence of specific health care events in administrative data is central to many quality improvement and research efforts. Many...Full Text Available

UK PubMed Central (United Kingdom)

Borrelial infection may manifest with a wide range of clinical signs, and in many cases, microbiological findings are essential for a proper diagnosis. This study included 48 patients with a working...Full Text Available

UK PubMed Central (United Kingdom)

Human epidermal growth factor receptor 2 (HER2) is one of the most important prognostic and predictive factors for breast cancer patients. Recently, serum HER2...Full Text Available

UK PubMed Central (United Kingdom)

Lifetime exposure to physical activity is an important construct for evaluating associations between physical activity and disease outcomes, given the long induction periods in many chronic diseases....Full Text Available

UK PubMed Central (United Kingdom)

Although the Kaiser Physical Activity Survey (KPAS) was a potential instrument for cross cultural research of midlife women, little information is available on its reliability and validity among...Full Text Available

UK PubMed Central (United Kingdom)

We have developed and validated a microporous poly(ethylene terephthalate) membrane-based indirect co-culture system for human pluripotent stem cell (hPSC) propagation, which allows real-time...Full Text Available

UK PubMed Central (United Kingdom)

OBJECTIVE. This study was conducted to determine whether an index for measuring quality of care for psychiatric emergencies is reliable and valid. DATA SOURCES/STUDY SETTING. The study used primary...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

NUPEC has carried out hydrogen mixing tests to investigate hydrogen distribution behavior within a model containment and to provide a set of experimental data for validation of severe accident analysis codes.

UK PubMed Central (United Kingdom)

ObjectiveTo examine the validity of the Patient Health Questionnaire - 2 (PHQ-2), a 2-item depression screening scale among adolescents.Full Text Available

UK PubMed Central (United Kingdom)

Purpose:To investigate the clinical usage of dose verification of Helical Tomotherapy plans by using 2D-array ion chambers, and to develop an efficient way to validate the dose delivered...Full Text Available

UK PubMed Central (United Kingdom)

Attention has shifted from the treatment of colorectal cancer (CRC) to chemoprevention using aspirin and folic acid as agents capable of preventing the onset of colon cancer. However, no sensitive...Full Text Available

Science.gov (United States)

Page 1. Page 2. Page 3. Page 4. Page 5. Page 6. Page 7. Page 8. Page 9. Page 10. Page 11. Page 12. Page 13. Page 14. Page 15. Page 16. Page ...

UK PubMed Central (United Kingdom)

Mass balance relations, valid for any counterflow system, are derived and applied to a central core model of the renal medulla, in which descending Henle's limbs (DHL), ascending Henle's limbs (AHL),...Full Text Available

UK PubMed Central (United Kingdom)

A nucleic acid extraction system that can handle small numbers of specimens with a short test turnaround time and short hands-on time is desirable for emergent testing. We performed a comparative validation...Full Text Available

Science.gov (United States)

... Page 2. Boston Scientific CRM 11/17/09 MADIT-CRT Clinical Report APPENDIX B 2 CONFIDENTIAL ... B-2 Primary Effectiveness B-2.1 Validation of Assumptions ...

Energy Technology Data Exchange (ETDEWEB)

In 1992, the Federal Energy Regulatory Commission (FERC) began using a Flow Duration Analysis (FDA) methodology to assess headwater benefits in river basins where use of the Headwater Benefits Energy Gains (HWBEG) model may not result in significant improvements in modeling accuracy. The purpose of this study is to validate the accuracy and appropriateness of the FDA method for determining energy gains in less complex basins. This report presents the results of Oak Ridge National Laboratory`s (ORNL`s) validation of the FDA method. The validation is based on a comparison of energy gains using the FDA method with energy gains calculated using the MWBEG model. Comparisons of energy gains are made on a daily and monthly basis for a complex river basin (the Alabama River Basin) and a basin that is considered relatively simple hydrologically (the Stanislaus River Basin). In addition to validating the FDA ...

UK PubMed Central (United Kingdom)

Human arylamine N-acetyltransferase (NAT) activity is determined by two distinct genes, NAT1 and NAT2, and the classical acetylation polymorphism in NAT2 has been associated with a variety of disorders,...Full Text Available

UK PubMed Central (United Kingdom)

Large-scale cancer genome projects will soon be able to sequence many cancer genomes to comprehensively identify genetic changes in human cancer. Genome-wide association studies have also identified...Full Text Available

British Library Electronic Table of Contents (United Kingdom)

The purpose of this study was to assess the utility of the Arabic translation of the Alcohol Use Disorders Identification Test (AUDIT) among a sample of male Muslim prisoners (N = 107) in Dubai, United Arab Emirates (UAE). Confirmatory factor analysis indicated a two-factor model to be the best fit of the data. Good internal reliability (a =.91) and predictive validity were also observed. While the limitations of the study are observed, these promising results suggest that the Arabic version of the AUDIT is a reliable and sound measure of alcohol use disorders among prisoners in the UAE.

International Nuclear Information System (INIS)

The radiative transport problem is cast in integral form using a transport kernel. The transport kernel has an explicit representation in terms of a Feynman Path Integral over all paths between selected points in a volume. This representation is setup in detail. Numerical evaluation of this Path Integral is formulated with a Frenet-Serret based procedure for generating valid random paths, and with a numerical evaluation of the weight for each valid path. Very early sanity checks of a numerical implementation are reported. Approaches to optimization are identified. (authors)

CERN Document Server

Where Stuff Comes From

Energy Technology Data Exchange (ETDEWEB)

In 15 children (in age 2 weeks - 15 years) the computer tomography beside radiological examination was done because of mediastinal diseases. In all cases the computer tomography was valuable. In 4 cases obtained results have changed diagnostic conclusions. The examples are described showing the usefulness of the computer tomography as supplementary diagnostic method in mediastinal diseases in children.

Science.gov (United States)

PMID:12556767

CERN Multimedia

With Novartis, Grid-Computing has an industrial use

International Science & Technology Center (ISTC)

Photochromes for New Generation of Highly Efficient Computers with Three Dimensional (3D) Optical Memory

Energy Technology Data Exchange (ETDEWEB)

The basic objective of this project was to consider a large class of matrix computations with particular emphasis on algorithms that can be implemented on arrays of processors. In particular, methods useful for sparse matrix computations were investigated. These computations arise in a variety of applications such as the solution of partial differential equations by multigrid methods and in the fitting of geodetic data. Some of the methods developed have already found their use on some of the newly developed architectures.

Science.gov (United States)

... Note that the terminal ... Probability and Statistics with Reliability, Queueing, and Computer ... Weiss, G., "Stochastic Bounds on Distributions of Optimal ...

Science.gov (United States)

A computer program entitled "Marshall Aerospace Vehicle Representation in C II,

Science.gov (United States)

... personal computers low-cost information management capabilities to television's uncanny ability to motivate and communicate. ...

Science.gov (United States)

... 14 Face Detection ..... 14 Automated Mapping ...

Science.gov (United States)

... (Author). Descriptors : (*TERMINAL FLIGHT FACILITIES ... PROGRAMMING, HANDLING), QUEUEING THEORY, STOCHASTIC PROCESSES ...

Energy Technology Data Exchange (ETDEWEB)

Published in summary form only.

International Nuclear Information System (INIS)

Published in summary form only.

Science.gov (United States)

Not Available

Energy Technology Data Exchange (ETDEWEB)

No abstract prepared.

Science.gov (United States)

PMID:21878105

Science.gov (United States)

In 1963, Grover and co-workers at the Los Alamos. Scientific. Laboratory ...... and A. P. Watkins. (1986) "The Computation of Compressible ...

British Library Electronic Table of Contents (United Kingdom)

Due to recent advancements in mobile computing and communication technologies, mobile ad hoc computational Grids are emerging as a new computing paradigm, enabling innovative applications through sharing of computing resources among mobile devices without any pre-existing network infrastructure. Energy-efficient resource allocation is one of the key issues in mobile ad hoc computational Grids due to limited battery life of mobile nodes. To reduce energy consumption, we propose a hybrid power-based resource allocation scheme for allocation of interdependent tasks to nodes within mobile ad hoc computational Grid. The basic idea is to exploit dependencies and task type, and allocate interdependent tasks to nodes accessible at minimum transmission power. We also propose a power-based algorithm...

International Nuclear Information System (INIS)

Nuclear physics parameters of the Wolsung CANDU-PHW reactor are computed by use of the PHWCELL computer code that is an improved version of LATREP. The PHWCELL code mainly computes cell parameters of heavy water moderated reactors, and modeling scheme of heavy water reactor cell calculations has been developed with the PHWCELL computer code. The reactor operating conditions considered in the study are cold zero power (CZP) and hot full power (HFP) with equilibrium poison. The cell parameters are also computed as a function of fuel burnup and the numerical results are compared with the results in PSR of the Wolsung unit and in the previous study. (author).

Energy Technology Data Exchange (ETDEWEB)

The method, use and results of computer-aided diagnosis of bone tumours and tumour-like skeletal abnormalities in childhood are described. One hundred and twentyone histologically verified cases were analysed and subjected to computer-aided diagnosis. Statistical methods were used, resulting in an accuracy of 96.7% and 91.7% respectively. In order to obtain additional confirmation of the diagnosis, a so-called growth rate was calculated by the computer. This proved to be a reliable criterion for evaluating the biological behaviour of tumours, irrespective of the histological diagnosis. The reasons for misdiagnosis were discussed. Attention is drawn to the importance of an accurate analysis of the radiographs and its input into the computer.

Science.gov (United States)

This is the homepage of "an Australian multi-university collaboration undertaking research on the fundamental physics and technology of building, at the atomic level, a solid state quantum computer in silicon together with other high potential implementations." Although attempts to develop a quantum computer have met with limited success, the centre has substantial resources invested in advancing toward practical uses of quantum computing technology. The site provides a very good introduction to the principles and implications of quantum computing, as well as details about various research projects underway at the Australian universities. Links to conference and journal papers produced by members of the centre, many from 2003, are also provided.

International Nuclear Information System (INIS)

In various situations, measurements in prompt gamma neutron activation analysis (PGNAA) are performed to determine the amount of an elemental impurity relative to that of a major constituent of the matrix. An example of this is the measurement of hydrogen concentration in a metallic matrix. In all such cases, a major contributor to the uncertainty in the measurement is the uncertainty in the ratio of the high-purity germanium (HPGe) detector full-energy peak efficiency for the gamma-ray lines of interest (i.e., impurity and matrix gammas). Usually, the ratio is derived from the relative peak efficiency curve, which is determined using isotopic standards that emit multiple gamma ray lines (e.g., "1"5"2Eu) in the energy range <3000 keV, or using prompt gamma radionuclides (e.g., "1"4N, "3"5Cl) in the energy range >3000 keV. In either case, the uncertainty in the ratio of the peak efficiency values derived from such measurements will be on the order of a few percent at best because ...

Scientific Electronic Library Online (English)

Abstract in english The aim of this study was to verify validity and reliability of the scores for physical exercise in leisure (PEL), leisure and locomotion activities (LLA), and total score (TS) of the Baecke habitual physical activity questionnaire in adult males. Twenty-one students of Physical Education were evaluated. For validation, the maximum oxygen uptake (O2max) and the decrease of the heart rate in percentile (%DH (more) R) were measured through the Cooper's 12-minute walk or run test, and an annual index of physical exercise (IPE), and a week index of locomotion activities (ILA). The reliability was verified through test-retest with interval of 45 days. The Pearson correlation coefficient, and partial correlation adjusted for age and body mass index were used for validation. The intraclass correlation and paired t-test were used for reliability. The results indicated that %DHR was correlated with LLA and TS (r ...

Energy Technology Data Exchange (ETDEWEB)

Discussed in this report is a wavefield simulation in the 3-dimensional seismic survey. With the level of the object of exploration growing deeper and the object more complicated in structure, the survey method is now turning 3-dimensional. There are several modelling methods for numerical calculation of 3-dimensional wavefields, such as the difference method, pseudospectral method, and the like, all of which demand an exorbitantly large memory and long calculation time, and are costly. Such methods have of late become feasible, however, thanks to the advent of the parallel computer. As compared with the difference method, the pseudospectral method requires a smaller computer memory and shorter computation time, and is more flexible in accepting models. It outputs the result in fullwave just like the difference method, and does not cause wavefield numerical variance. As the computation platform, the ...

Energy Technology Data Exchange (ETDEWEB)

Science and technology could be revolutionized by quantum computers, but building them from solid-state devices will not be easy. Robert W Keyes of IBM's research division outlines the challenges in scaling up the technology from lab experiments to practical devices. (U.K.)

Science.gov (United States)

Aug 8, 2011 ... Panel > Cloudenomics 101 What Cloud Computing Really Means for NASA. 11:00 am in Collaboration, LiveCall by Lucas Cioffi (Moderator) ...

UK PubMed Central (United Kingdom)

Motivation: The identification of gene regulatory modules is an important yet challenging problem in computational biology. While many computational methods have been proposed to identify...Full Text Available

UK PubMed Central (United Kingdom)

The percentages of total airflows over the nasal respiratory and olfactory epithelium of female rabbits were calculated from computational fluid dynamics (CFD) simulations of steady-state inhalation....Full Text Available

Science.gov (United States)

Page 1. Mt N Local Spatial Frequency Analysis N for Computer Vision N John Krumm and Steven A. Shafer CMU-RI-TR-90-1 1 JUNO0 8 199 0 ...

Science.gov (United States)

Cyber attacks on a hospital's computer network is a new crime to be reckoned with. Should your hospital consider internet insurance? The author explains this new phenomenon and presents a risk assessment for determining network vulnerabilities. PMID:11951384

Energy Technology Data Exchange (ETDEWEB)

Experience has shown that a list of tips provides designers and engineers with an effective guide in their areas of duties and concern. This list contains new and rare information on heat exchangers and heat recovery systems. The information presented can be used effectively with personal computers and pocket calculators and also conveniently translated into computer programs and nomographs.