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Sample records for v-notch results show

  1. Ductile crack initiation in the Charpy V-notch test

    International Nuclear Information System (INIS)

    Initiation and growth of a crack in the Charpy V-notch test was investigated by performing both static and impact controlled deflection tests. Test specimens were deformed to various deflections, heat-tinted to mark crack extension and broken apart at low temperature to allow extension measurements. Measurement of the crack extension provided an estimate of crack initiation as defined by different criteria. Crack initiation starts well before maximum load, and is dependent on the definition of ''initiation''. Using a definition of first micro-initiation away from the ductile blunting, computer model predictions agreed favorably with the experimental results

  2. Results of charpy V-notch impact testing of structural steel specimens irradiated at ?30 degrees C to 1 x 1016 neutrons/cm2 in a commercial reactor cavity

    International Nuclear Information System (INIS)

    A capsule containing Charpy V-notch (CVN) and mini-tensile specimens was irradiated at ? 30 degrees C (? 85 degrees F) in the cavity of a commercial nuclear power plant to a fluence of 1 x 1016 neutrons/cm2 (> 1MeV). The capsule included six CVN impact specimens of archival High Flux Isotope Reactor A212 grade B ferritic steel and five CVN impact specimens of a well-studied A36 structural steel. This irradiation was part of the ongoing study of neutron-induced damage effects at the low temperature and flux experienced by reactor supports. The plant operators shut down the plant before the planned exposure was reached. The exposure of these specimens produced no significant irradiation-induced embrittlement. Of interest were the data on unirradiated specimens in the L-T orientation machined from a single plate of A36 structural steel, which is the same specification for the structural steel used in some reactor supports. The average CVN energy of five unirradiated specimens obtained from one region of the plate and tested at room temperature was ? 99 J, while the energy of 11 unirradiated specimens from other locations of the same plate was 45 J, a difference of ? 220%. The CVN impact energies for all 18 specimens ranged from a low of 32 J to a high of 111 J. Moreover, it appears that the University of Kansas CVN impact energy data of the unirradiated specimens at the 100-J level are shifted toward higher temperatures by about 20 K. The results were an example of the extent of scatter possible in CVN impact testing. Generic values for the CVN impact energy of A36 should be used with caution in critical applications

  3. Ductile crack initiation in the Charpy V-notch test

    International Nuclear Information System (INIS)

    Crack initiation and growth in the Charpy V-notch test are investigated for controlled deflections of the specimen applied both by slow bending and by impact. Charpy test specimens were deformed to various deflections, heat-tinted to mark the crack extensions, and broken apart at low temperature to allow measurement of the crack extensions. These measurements provide estimates of crack initiation as defined by various criteria. The loading point at which crack initiation occurs depends on the particular definition being used for ''initiation,'' but in all cases it is well before the maximum load is reached. When initiation is defined as the first observable micro-initiation away from the ductile blunting of the notch root, the experimental results are in good agreement with computer modeling predictions

  4. Charpy V-notch impact testing and brittle fracture in an A508 CL.3 bainitic steel

    International Nuclear Information System (INIS)

    Charpy V-notch impact testing is widely used in the toughness diagnostic of large forged components, e.g. the vessel of pressurized water reactors (PWR). In an A508 Cl.3 bainitic steel tested at low temperature, cleavage occurs at the initiation of unstable failure. The results reported here are part of both an experimental program and numerical investigations in order to establish a non-empirical relationship between Charpy V-notch energy CVN and fracture toughness KIC. The Beremin model which is based on a critical fracture stress concept and Weibull statistics, is only applied on CVN tests. (orig.)

  5. Charpy V-Notch Impact Testing and Brittle Fracture in an A508 CL.3 Bainitic Steel

    OpenAIRE

    Tahar, M.; Brillaud, C.; Forget, P.; Piques, R.

    1997-01-01

    Charpy V-notch impact testing is widely used in the toughness diagnostic of large forged components, e.g. the vessel of pressurized water reactors (PWR). In an A508 Cl.3 bainitic steel tested at low temperature, cleavage occurs at the initiation of unstable failure. The results reported here are part of both an experimental program and numerical investigations in order to establish a non-empirical relationship between Charpy V-notch energy CVN and fracture toughness KIC. The Beremin model whi...

  6. Effect of V Notch Shape on Fatigue Life in Steel Beam Made of AISI 1037

    Directory of Open Access Journals (Sweden)

    Qasim Bader

    2014-04-01

    Full Text Available The present work encompasses effect of V notch shape with various geometries and dimensions on fatigue life behavior in steel beam made of Medium Carbon Steel AISI 1037 which has a wide application in industry. Fatigue life of notched specimens is calculated using the fatigue life obtained from the experiments for smooth specimens (reference and by use Numerical method (FEA.The fatigue experiments were carried out at room temperature, applying a fully reversed cyclic load with the frequency of (50Hz and mean stress equal to zero (R= -1, on a cantilever rotating-bending fatigue testing machine. The stress ratio was kept constant throughout the experiment. Different instruments have been used in this investigation like Chemical composition analyzer type (Spectromax ,Tensile universal testing machine type (WDW-100E ,Hardness tester type (HSV- 1000 , Fatigue testing machine model Gunt WP 140, Optical Light Microscope (OLM and Scanning Electron Microscope (SEM were employed to examine the fracture features . The results show that there is acceptable error between experimental and numerical works .

  7. Use of forces from instrumented Charpy V-notch testing to determine crack-arrest toughness

    International Nuclear Information System (INIS)

    The objective of this investigation is an estimation of the crack-arrest toughness, particularly of irradiated materials, from voltage versus time output of an instrumented setup during a test on a Charpy V-notch (CVN) specimen. This voltage versus time trace (which can be converted to force versus displacement) displays events during fracture of the specimen. Various stages of the fracture process can be identified on the trace, including an arrest point indicating arrest of brittle fracture. The force at arrest, Fa, versus test temperature, T, relationship is examined to explore possible relationships to other experimental measures of crack-arrest toughness such as the drop-weight nil-ductility temperature (NDT), or crack-arrest toughness, Ka. For a wide range of weld and plate materials, the temperature at which Fa = 2.45 kN correlates with NDT with a standard deviation, sigma, of about 11 K. Excluding the so-called low upper-shelf energy (USE) welds from the analysis resulted in Fa = 4.12 kN and ? = 6.6 K. The estimates of the correlation of the temperature for Fa = 7.4 kN with the temperature at 100-MPa?m level for a mean American Society of Mechanical Engineers (ASME) type KIa curve through crack-arrest toughness values show that prediction of conservative values of Ka are possible

  8. Critical Value for Crack Propagation from Sharp V-Notch.

    Czech Academy of Sciences Publication Activity Database

    Náhlík, Luboš; Štegnerová, Kate?ina; Huta?, Pavel; Majer, Z.

    Zurich : Trans Tech Publications, 2014 - (Šandera, P.), s. 177-180 ISBN 978-3-03785-934-6. ISSN 1013-9826. - (Key Engineering Materials. 592-593). [MSMF 7 - International Conference on Materials Structure & Micromechanics of Fracture /7./. Brno (CZ), 01.07.2013-03.07.2013] R&D Projects: GA MŠk(CZ) EE2.3.20.0214 Grant ostatní: VUT(CZ) FSIJ- 13-2046 Institutional support: RVO:68081723 Keywords : V-notch * linear elastic fracture mechanics * stress singularity * generalized stress intensity factor * generalized strain energy density factor Subject RIV: JL - Materials Fatigue, Friction Mechanics

  9. Computer model for ductile fracture: applications to the Charpy V-notch test. Phase one report

    International Nuclear Information System (INIS)

    A computer model for predicting ductile-fracture initiation and propagation in nuclear reactor pressure vessel steel is described. The model predicts fracture toughness from Charpy and tension tests using standard surveillance specimens. The fracture model is based on plastic strain. Fracture starts or a crack extends when the integrated product of the equivalent plastic-strain increment and a function of the mean stress exceeds a critical value over a critical length. This critical length is characteristic of the microstructure of the material. The computer fracture model is calibrated by computer simulation of simple and notched round-bar tension tests and a precracked compact tension test of A533 Grade B Class 1 steel and two different heat treatments of this steel. The model is then used to predict fracture initiation and flat propagation in the standard Charpy V-notch specimen. The computed results are compared with experiments. A correlation is presented between the energy in the Charpy V-notch specimen at fracture initiation on the upper shelf and fracture toughness as measured by J/sub Ic/

  10. Use of forces from instrumented Charpy V-notch testing to determine crack-arrest toughness

    Energy Technology Data Exchange (ETDEWEB)

    Iskander, S.K.; Nanstad, R.K.; Sokolov, M.A.; McCabe, D.E.; Hutton, J.T.

    1996-06-01

    The objective of this investigation is an estimation of the crack-arrest toughness, particularly of irradiated materials, from voltage versus time output of an instrumented setup during a test on a Charpy V-notch (CVN) specimen. This voltage versus time trace (which can be converted to force versus displacement) displays events during fracture of the specimen. Various stages of the fracture process can be identified on the trace, including an arrest point indicating arrest of brittle fracture. The force at arrest, F{sub a}, versus test temperature, T, relationship is examined to explore possible relationships to other experimental measures of crack-arrest toughness such as the drop-weight nil-ductility temperature (NDT), or crack-arrest toughness, K{sub a}. For a wide range of weld and plate materials, the temperature at which F{sub a} = 2.45 kN correlates with NDT with a standard deviation, sigma, of about 11 K. Excluding the so-called low upper-shelf energy (USE) welds from the analysis resulted in F{sub a} = 4.12 kN and {sigma} = 6.6 K. The estimates of the correlation of the temperature for F{sub a} = 7.4 kN with the temperature at 100-MPa{radical}m level for a mean American Society of Mechanical Engineers (ASME) type K{sub Ia} curve through crack-arrest toughness values show that prediction of conservative values of K{sub a} are possible.

  11. Determination of the toughness of a low alloy steel from the Charpy V-notch impact testing

    International Nuclear Information System (INIS)

    Charpy V-notch (CVN) impact testing is widely used to characterize the resistance of a material to brittle fracture, by measuring the energy consumed by a specimen during impact. Notably materials undergoing a ductile-to-brittle transition, e.g. ferritic steels, are quality controlled by means of CVN testing, and their ductile-to-brittle transition temperature can be determined. Charpy testing is also widely used in the toughness assessment of large forged components, e.g. pressure vessels for pressurised water reactors (PWR). However, currently no satisfactory link between the Charpy impact energy CVN and the fracture toughness KIc exists. This study aims to establish a non-empirical relationship between the Charpy V-notch energy CVN, and the fracture toughness KIc, on the lower shelf of fracture toughness and the onset of the ductile-to-brittle transition of a A508 Cl.3 steel. The methodology employed is based on the so-called 'local approach'. Brittle cleavage fracture is modelled in terms of the Beremin (1983) model based on 'weakest link' statistics, whereas ductile crack advance preceding cleavage in the transition region is accounted for with the GTN model (Gurson, 1977; Tvergaard, 1982; Tvergaard and Needleman, 1984). Mechanical testing at different strain rates allowed for the establishment of the constitutive equations of the material in an elastic-viscoplastic formulation. Fracture tests on different specimen geometries provided the large data set necessary for statistical evaluation. All specimen types have been modelled with finite element analysis. However, the dynamic nature of the Charpy test requires special consideration. The origin of these dynamic effects was studied, as well as their implications on interpretation of experimental results and on modeling. After a proper modeling procedure had been defined, the local approach was employed for studying fracture. It is found that the fracture toughness can be predicted from the Charpy impact test, on the lower shelf. Towards higher fracture toughness, the parameters of the Beremin model change, losing their universality. Detailed fractographic investigations show that the nature of 'weak spots' inducing cleavage fracture changes with temperature. Furthermore, the local cleavage fracture stress acting on these 'weak spots' was found to change with temperature. The results are in agreement with those obtained by Renevey (1997) in a previous study on the same material. Thus it is concluded that the Beremin model must be refined in order to be applicable in the ductile-to-brittle transition region. (author)

  12. Critical applied stresses for a crack initiation from a sharp V-notch

    Directory of Open Access Journals (Sweden)

    L. Náhlík

    2014-10-01

    Full Text Available The aim of the paper is to estimate a value of the critical applied stress for a crack initiation from a sharp V-notch tip. The classical approach of the linear elastic fracture mechanics (LELM was generalized, because the stress singularity exponent differs from 0.5 in the studied case. The value of the stress singularity exponent depends on the V-notch opening angle. The finite element method was used for a determination of stress distribution in the vicinity of the sharp V-notch tip and for the estimation of the generalized stress intensity factor depending on the V-notch opening angle. Critical value of the generalized stress intensity factor was obtained using stability criteria based on the opening stress component averaged over a critical distance d from the V-notch tip and generalized strain energy density factor. Calculated values of the critical applied stresses were compared with experimental data from the literature and applicability of the LEFM concept is discussed.

  13. Material inertia and size effects in the Charpy V-notch test

    DEFF Research Database (Denmark)

    Desandre, D. A.; Benzerga, A. A.

    2004-01-01

    The effect of material inertia on the size dependence of the absorbed energy in the Charpy V-notch test is investigated. The material response is characterized by an elastic-viscoplastic constitutive relation for a porous plastic solid, with adiabatic heating due to plastic dissipation and the resulting thermal softening accounted for. The onset of cleavage is taken to occur when a critical value of the maximum principal stress is attained over a critical volume. Plane strain dynamic analyses are carried out for geometrically similar specimens of various sizes with all parameters adjusted so that a quasi-static analysis would predict a size independent response. Sizes ranging from 1/4 to 16 times the ASTM standard size are analyzed and two sets of material properties are considered. No size effect is seen below a critical specimen size. Above this limit, a monotonic increase with specimen size is found for the normalized lower shelf energy (LSE) and the normalized upper shelf energy (USE) for both sets of material properties. The ductile-to-brittle transition temperature (DBTT) is found to increase monotonically with specimen size for one set of material properties, but a non-monotonic variation is found for the other set of material properties. (C) 2004 Elsevier SAS. All rights reserved.

  14. Weld investigations by 3D analyses of Charpy V-notch specimens

    DEFF Research Database (Denmark)

    Tvergaard, Viggo; Needleman, Allan

    2005-01-01

    The Charpy impact test is a standard procedure for determining the ductile-brittle transition in welds. The predictions of such tests have been investigated by full three dimensional transient analyses of Charpy V-notch specimens. The material response is characterised by an elastic-viscoplastic constitutive relation for a porous plastic solid, accounting for adiabatic heating due to plastic dissipationfiand the resulting thermal softening. The onset of cleavage is taken to occur when the average of the maximum principal stress over a speci¯ed volume attains a critical value. Typically, the material parameters in the weld material differ from those in the base material, and the heat a®ected zone (HAZ) tends to be more brittle than the other material regions. The effect of weld strength undermatch or overmatch is an important issue. Some specimens, for which the notched surface is rotated relative to the surface of the test piece, have so complex geometry that only a full 3D analysis is able to account for theinteraction of failure in the three different material regions, whereas ther specimens can be approximated in terms of a planar analysis.

  15. CALIBRATION OF A 90 DEGREE V-NOTCH WEIR USING PARAMETERS OTHER THAN UPSTREAM HEAD

    Science.gov (United States)

    Traditional calibration of 90 degrees V-Notch Weirs has involved the establishment of a head-discharge relationship where the head is measured upstream of weir drawdown effects. This parameter is often difficult to mesure in field weir installations. Two other parameters are prop...

  16. Evaluation of fracture toughness in dental ceramics using indentation and SEVNB (Single Edge V-Notched Beam)-method

    International Nuclear Information System (INIS)

    In this work, the fracture toughness of different ceramics based on Al2O3 and ZrO2 were evaluated using, comparatively two methods, Vickers indentation and SEVNB (Single Edge V-Notched Beam) method. Al2O3, ZrO2(3%Y2O3) micro-particled and ZrO2(3%Y2O3) nanometric, ZrO2-Al2O3 and Al2O3-ZrO2 composites were sintered at different temperatures. Samples were characterized by relative density, X-ray diffraction, SEM, and mechanical evaluation by hardness, bending strength and fracture toughness obtained by ickers indentation and SEVNB-method. The results were presented comparing the densification and microstructural results. Furthermore, the advantages and limitations of each method were discussed. (author)

  17. Analysis of the Charpy V-notch test for welds

    DEFF Research Database (Denmark)

    Tvergaard, Viggo; Needleman, A.

    2000-01-01

    The ductile-brittle transition for a weld is investigated by numerical analyses of Charpy impact specimens. The material response is characterized by an elastic-viscoplastic constitutive relation for a porous plastic solid, with adiabatic heating due to plastic dissipation and the resulting thermal softening accounted for. The onset of cleavage is taken to occur when a critical value of the maximum principal stress is attained. The effect of weld strength undermatch or overmatch is investigated for a comparison material, and analyses are also carried out based on experimentally determined flow strength variations in a weldment in a HY100 steel. The predicted work to fracture shows a strong sensitivity to the location of the notch relative to the weld, with the most brittle behavior for a notch close to the narrow heat affected zone. The analyses illustrate the strong dependence of the transition temperature on stress triaxiality. (C) 2000 Elsevier Science Ltd. All rights reserved.

  18. Estimation of critical values for crack initiation from sharp V-notches.

    Czech Academy of Sciences Publication Activity Database

    Náhlík, Luboš; Štegnerová, Kate?ina; Huta?, Pavel

    Brno : Brno University of Technology. Institute of Solid Mechanics, Mechatronics and Biomechanics, 2014 - (Fuis, V.), s. 412-415 ISBN 978-80-214-4871-1. ISSN 1805-8248. [Engineering Mechanics 2014 /20./. Svratka (CZ), 12.05.2014-15.05.2014] R&D Projects: GA MŠk(CZ) EE2.3.30.0063 Institutional support: RVO:68081723 Keywords : Failure initiation * stress singularity * V-notch * generalized stress intensity factor Subject RIV: JL - Materials Fatigue, Friction Mechanics

  19. Effect of V Notch Shape on Fatigue Life in Steel Beam Made of AISI 1037

    OpenAIRE

    Qasim Bader; Emad Kadum

    2014-01-01

    The present work encompasses effect of V notch shape with various geometries and dimensions on fatigue life behavior in steel beam made of Medium Carbon Steel AISI 1037 which has a wide application in industry. Fatigue life of notched specimens is calculated using the fatigue life obtained from the experiments for smooth specimens (reference) and by use Numerical method (FEA).The fatigue experiments were carried out at room temperature, applying a fully reversed cyclic load wi...

  20. The Evolution of the Maine Lobster V-Notch Practice: Cooperation in a Prisoner's Dilemma Game

    OpenAIRE

    Roy Gardner; James Acheson

    2011-01-01

    The Maine lobster industry is experiencing record high catches because, in all probability, of an effective management program. One of the most important conservation measures is the V-notch program that allows fishermen to conserve proven breeding females by notching the tails of egg-bearing lobsters. Such marked lobsters may never be taken. Although thousands of lobster fishermen participate, it is a voluntary practice. The genesis of this practice is not easily explained, because V-notchin...

  1. Critical applied stresses for a crack initiation from a sharp V-notch.

    Czech Academy of Sciences Publication Activity Database

    Náhlík, Luboš; Huta?, Pavel; Štegnerová, Kate?ina

    Vol. 8. Catania : Gruppo Italiano Frattura, 2014, s. 55-61. ISBN 978-88-95940-49-6. ISSN 1971-8993. - (30). [Fracture and Structural Integrity related Issues. Catania (IT), 15.09.2014-17.09.2014] R&D Projects: GA MŠk(CZ) EE2.3.30.0063; GA MŠk(CZ) EE2.3.20.0214 Institutional support: RVO:68081723 Keywords : Crack initiation * V-notch * critical stress * strain energy density factor * generalized linear elastic fracture mechanics * fracture criteria Subject RIV: JL - Materials Fatigue, Friction Mechanics

  2. Analysis of Charpy V-notch impact toughness of irradiated A533-B class 1 plate and four submerged-arc welds

    International Nuclear Information System (INIS)

    Studies of the effects of neutron irradiation on Charpy V-notch impact properties of steels have, in general, included a minimum number of tests for each combination of material and irradiation parameters. The present study attempts to apply statistical analyses with multiple testing at selected temperatures to assess the accuracy and reliability of results. Charpy V-notch impact test specimens were irradiated in the Bulk Shielding Reactor at Oak Ridge National Laboratory at 2880C to target neutron fluences of 2 X 1023 neutrons (n)/m2 (>1 MeV). The materials were ASTM A533-B Class 1 plate (HeavySection Steel Technology Plate 02) and four submerged-arc welds representing current nuclear pressure vessel fabrication practice. Both unirradiated and irradiated specimens were tested by two separate groups and multiple tests were conducted at several selected temperatures. Statistical analyses permitted determination of material and test variability and an interlaboratory comparison. Several Charpy curve-fitting methods were used and results are compared with predictions from several ''trend curve'' expressions

  3. Relationships between Charpy V-notch impact energy and fracture toughness

    International Nuclear Information System (INIS)

    This report documents the investigation of correlations between Charpy V-notch impact energy and fracture toughness. Three distinct types of correlations were examined: (1) the Rolfe-Novak-Barsom upper-shelf correlation, (2) the hyperbolic tangent (tanh) correlation, and (3) the J-?a correlation. The Rolfe-Novak-Barsom correlation is a straight line relationship between functions of the Charpy energy and the static initiation toughness, while the tanh correlation relates functions of the Charpy energy and either the static or the dynamic toughness through the use of statistically determined curve fits based on the tanh curve. The J-?a correlation represents power law estimates of resistance curves in the upper-shelf temperature range

  4. Charpy impact and slow-bend tests for substandard V-notched and side-grooved specimens

    International Nuclear Information System (INIS)

    Energy correlations between standard and substandard specimens on USE and energy correlations in different stress states due to the effects of side grooving were performed with substandard Charpy specimens. In addition to impact tests slow-bend tests were conducted to study the side grooving effects on stable crack growth at the front notch tip and on triaxiality at the side notch tip by fractographs. To extract some useful engineering parameters nonlinear V-notch fracture toughness tests were also carried out for the substandard notched and side grooved specimens. Both area and volume normalizations provided good agreements on USE correlation and the geometrical correction factor (B/BN) reduced the stress state effects due to the side grooving on energy correlations. Side grooves reduced the stable crack growth region and enhanced the triaxiality near the side notch tip to a brittle fracture. The values of nonlinear V-notch fracture toughness (Gcv) with 30% side grooving had uniform values through specimen thickness from 10 mm to 5 mm for 10 mm width

  5. Preparation of reconstituted Charpy V-notch impact specimens for generating pressure vessel steel fracture toughness data

    International Nuclear Information System (INIS)

    The arc stud welding process has been adapted for use in producing reconstituted Charpy V-notch impact specimens. In this process, each half of a tested and fractured Charpy specimen is used as the central region of a reconstituted specimen. End tabs are joined to one half of a fractured specimen by a specially designed stud welding apparatus. SA533B-1 and SA508-2 unirradiated and irradiated pressure vessel steel specimens have been produced. Both conventional and precracked reconstituted specimen data have been produced. Both types of data have been shown to be in excellent agreement with original specimen data. The arc stud welding process can therefore be used to increase the amount of data obtainable from a limited number of specimens or to obtain Charpy data when full size specimens cannot otherwise be obtained

  6. Primal and Shadow functions, Dual and Dual-Shadow functions for a circular crack and a circular 90 degree V-notch with Neumann boundary conditions

    OpenAIRE

    Shannon, Samuel; Yosibash, Zohar; Dauge, Monique; Costabel, Martin

    2012-01-01

    This report presents explicit analytical expressions for the primal, primal shadows, dual and dual shadows functions for the Laplace equation in the vicinity of a circular singular edge with Neumann boundary conditions on the faces that intersect at the singular edge. Two configurations are investigated: a penny-shaped crack and a 90^o V-notch.

  7. Astronomy Diagnostic Test Results Reflect Course Goals and Show Room for Improvement

    Science.gov (United States)

    LoPresto, Michael C.

    2007-01-01

    The results of administering the Astronomy Diagnostic Test (ADT) to introductory astronomy students at Henry Ford Community College over three years have shown gains comparable with national averages. Results have also accurately corresponded to course goals, showing greater gains in topics covered in more detail, and lower gains in topics covered…

  8. Dynamic Toughness Testing of Pre-Cracked Charpy V-Notch Specimens. Convention ELECTRABEL - SCK-CEN

    International Nuclear Information System (INIS)

    This document describes the experimental and analytical procedures which have been adopted at the laboratories of the Belgian Nuclear Research Centre SCK-CEN for performing dynamic toughness tests on pre-cracked Charpy-V specimens. Such procedures were chosen on the basis of the existing literature on the subject, with several updates in the data analysis stages which reflect more recent developments in fracture toughness testing. Qualification tests have been carried out on PCCv specimens of JRQ steel, in order to assess the reliability of the results obtained; straightforward comparisons with reference data have been performed, as well as more advanced analyses using the Master Curve approach. Aspects related to machine compliance and dynamic tup calibration have also been addressed

  9. Dynamic Toughness Testing of Pre-Cracked Charpy V-Notch Specimens. Convention ELECTRABEL - SCK-CEN

    Energy Technology Data Exchange (ETDEWEB)

    Lucon, E

    1999-04-01

    This document describes the experimental and analytical procedures which have been adopted at the laboratories of the Belgian Nuclear Research Centre SCK-CEN for performing dynamic toughness tests on pre-cracked Charpy-V specimens. Such procedures were chosen on the basis of the existing literature on the subject, with several updates in the data analysis stages which reflect more recent developments in fracture toughness testing. Qualification tests have been carried out on PCCv specimens of JRQ steel, in order to assess the reliability of the results obtained; straightforward comparisons with reference data have been performed, as well as more advanced analyses using the Master Curve approach. Aspects related to machine compliance and dynamic tup calibration have also been addressed.

  10. Stem cells show promising results for lymphoedema treatment - A literature review

    DEFF Research Database (Denmark)

    Toyserkani, Navid Mohamadpour; Christensen, Marlene Louise

    2015-01-01

    Abstract Lymphoedema is a debilitating condition, manifesting in excess lymphatic fluid and swelling of subcutaneous tissues. Lymphoedema is as of yet still an incurable condition and current treatment modalities are not satisfactory. The capacity of mesenchymal stem cells to promote angiogenesis, secrete growth factors, regulate the inflammatory process, and differentiate into multiple cell types make them a potential ideal therapy for lymphoedema. Adipose tissue is the richest and most accessible source of mesenchymal stem cells and they can be harvested, isolated, and used for therapy in a single stage procedure as an autologous treatment. The aim of this paper was to review all studies using mesenchymal stem cells for lymphoedema treatment with a special focus on the potential use of adipose-derived stem cells. A systematic search was performed and five preclinical and two clinical studies were found. Different stem cell sources and lymphoedema models were used in the described studies. Most studies showed a decrease in lymphoedema and an increased lymphangiogenesis when treated with stem cells and this treatment modality has so far shown great potential. The present studies are, however, subject to bias and more preclinical studies and large-scale high quality clinical trials are needed to show if this emerging therapy can satisfy expectations.

  11. Results From Mars Show Electrostatic Charging of the Mars Pathfinder Sojourner Rover

    Science.gov (United States)

    Kolecki, Joseph C.; Siebert, Mark W.

    1998-01-01

    Indirect evidence (dust accumulation) has been obtained indicating that the Mars Pathfinder rover, Sojourner, experienced electrostatic charging on Mars. Lander camera images of the Sojourner rover provide distinctive evidence of dust accumulation on rover wheels during traverses, turns, and crabbing maneuvers. The sol 22 (22nd Martian "day" after Pathfinder landed) end-of-day image clearly shows fine red dust concentrated around the wheel edges with additional accumulation in the wheel hubs. A sol 41 image of the rover near the rock "Wedge" (see the next image) shows a more uniform coating of dust on the wheel drive surfaces with accumulation in the hubs similar to that in the previous image. In the sol 41 image, note particularly the loss of black-white contrast on the Wheel Abrasion Experiment strips (center wheel). This loss of contrast was also seen when dust accumulated on test wheels in the laboratory. We believe that this accumulation occurred because the Martian surface dust consists of clay-sized particles, similar to those detected by Viking, which have become electrically charged. By adhering to the wheels, the charged dust carries a net nonzero charge to the rover, raising its electrical potential relative to its surroundings. Similar charging behavior was routinely observed in an experimental facility at the NASA Lewis Research Center, where a Sojourner wheel was driven in a simulated Martian surface environment. There, as the wheel moved and accumulated dust (see the following image), electrical potentials in excess of 100 V (relative to the chamber ground) were detected by a capacitively coupled electrostatic probe located 4 mm from the wheel surface. The measured wheel capacitance was approximately 80 picofarads (pF), and the calculated charge, 8 x 10(exp -9) coulombs (C). Voltage differences of 100 V and greater are believed sufficient to produce Paschen electrical discharge in the Martian atmosphere. With an accumulated net charge of 8 x 10(exp -9) C, and average arc time of 1 msec, arcs can also occur with estimated arc currents approaching 10 milliamperes (mA). Discharges of this magnitude could interfere with the operation of sensitive electrical or electronic elements and logic circuits. Sojourner rover wheel tested in laboratory before launch to Mars. Before launch, we believed that the dust would become triboelectrically charged as it was moved about and compacted by the rover wheels. In all cases observed in the laboratory, the test wheel charged positively, and the wheel tracks charged negatively. Dust samples removed from the laboratory wheel averaged a few ones to tens of micrometers in size (clay size). Coarser grains were left behind in the wheel track. On Mars, grain size estimates of 2 to 10 mm were derived for the Martian surface materials from the Viking Gas Exchange Experiment. These size estimates approximately match the laboratory samples. Our tentative conclusion for the Sojourner observations is that fine clay-sized particles acquired an electrostatic charge during rover traverses and adhered to the rover wheels, carrying electrical charge to the rover. Since the Sojourner rover carried no instruments to measure this mission's onboard electrical charge, confirmatory measurements from future rover missions on Mars are desirable so that the physical and electrical properties of the Martian surface dust can be characterized. Sojourner was protected by discharge points, and Faraday cages were placed around sensitive electronics. But larger systems than Sojourner are being contemplated for missions to the Martian surface in the foreseeable future. The design of such systems will require a detailed knowledge of how they will interact with their environment. Validated environmental interaction models and guidelines for the Martian surface must be developed so that design engineers can test new ideas prior to cutting hardware. These models and guidelines cannot be validated without actual flighata. Electrical charging of vehicles and, one day, astronauts moving across t

  12. FES Training in Aging: interim results show statistically significant improvements in mobility and muscle fiber size

    Directory of Open Access Journals (Sweden)

    Helmut Kern

    2012-06-01

    Full Text Available Aging is a multifactorial process that is characterized by decline in muscle mass and performance. Several factors, including reduced exercise, poor nutrition and modified hormonal metabolism, are responsible for changes in the rates of protein synthesis and degradation that drive skeletal muscle mass reduction with a consequent decline of force generation and mobility functional performances. Seniors with normal life style were enrolled: two groups in Vienna (n=32 and two groups in Bratislava: (n=19. All subjects were healthy and declared not to have any specific physical/disease problems. The two Vienna groups of seniors exercised for 10 weeks with two different types of training (leg press at the hospital or home-based functional electrical stimulation, h-b FES. Demografic data (age, height and weight were recorded before and after the training period and before and after the training period the patients were submitted to mobility functional analyses and muscle biopsies. The mobility functional analyses were: 1. gait speed (10m test fastest speed, in m/s; 2. time which the subject needed to rise from a chair for five times (5x Chair-Rise, in s; 3. Timed –Up-Go- Test, in s; 4. Stair-Test, in s; 5. isometric measurement of quadriceps force (Torque/kg, in Nm/kg; and 6. Dynamic Balance in mm. Preliminary analyses of muscle biopsies from quadriceps in some of the Vienna and Bratislava patients present morphometric results consistent with their functional behaviors. The statistically significant improvements in functional testings here reported demonstrates the effectiveness of h-b FES, and strongly support h-b FES, as a safe home-based method to improve contractility and performances of ageing muscles.

  13. Effects of oxidation on the impact energy of Hastelloy S and Hastelloy C-4 Charpy V-notch specimens heated in air at 6000 to 8000C

    International Nuclear Information System (INIS)

    The 90SrF2 heat source being developed at PNL utilizes a Hastelloy S or Hastelloy C-4 outer capsule having a 0.5-in.-thick wall to contain the Hastelloy C-276 inner capsule. The primary objective of the study was to demonstrate that the air oxidation of the outer capsule that could occur during heat-source service would not degrade the ductility and Charpy impact strength of the capsule below the licensing requirements given in Section 1.1. The 90SrF2 heat source under development is intended for general-purpose use. Compatibility considerations limit the interface temperature between the 90SrF2 and Hastelloy C-276 inner capsule to a maximum of 8000C. The outer capsule surface temperature will be somewhat less than 8000C, and depending on the service, may be substantially lower. The oxidation tests were therefore carried out at 6000 to 8000C for exposures up to 10,000h to cover the range of temperature the outer capsule might expect to encounter in service. The results showed that the oxidation of Hastelloy S and Hastelloy C-4 in air at 6000 to 8000C is very slow, and both alloys form adherent oxide layers that serve to protect the underlying metal. Subsurface attack of Hastelloy S and Hastelloy C-4 due to oxidation was greater than expected, considering the slow oxidation rates of the two alloys at 6000 to 8000C. Estimates of subsurface attack, determined from micrographs of the oxidized specimens, showed erratic results and it was impossible to assign any type of rate equation to the subsurface attack. A conservative estimate of long-term effects can be made using a linear extrapolation of the test results. There were no significant differences between the room-temperature Charpy impact energy of Hastelloy S and Hastelloy C-4 specimens oxidized in air at 6000 to 8000C and control specimens heated in vacuum

  14. News Note: Long-term Results from Study of Tamoxifen and Raloxifene Shows Lower Toxicities of Raloxifene

    Science.gov (United States)

    Initial results in 2006 of the NCI-sponsored Study of Tamoxifen and Raloxifene (STAR) showed that a common osteoporosis drug, raloxifene, prevented breast cancer to the same degree, but with fewer serious side-effects, than the drug tamoxifen that had been in use many years for breast cancer prevention as well as treatment. The longer-term results show that raloxifene retained 76 percent of the effectiveness of tamoxifen in preventing invasive disease and grew closer to tamoxifen in preventing noninvasive disease, while remaining far less toxic – in particular, there was significantly less endometrial cancer with raloxifene use.

  15. Numerical modelling of Charpy-V notch test by local approach to fracture. Application to an A508 steel in the ductile-brittle transition range

    International Nuclear Information System (INIS)

    Ferritic steels present a transition of the rupture mode which goes progressively of a brittle rupture (cleavage) to a ductile rupture when the temperature increases. The following of the difference of the transition temperature of the PWR vessel steel by the establishment of toughness curves makes of the Charpy test an integrating part of the monitoring of the French PWR reactors. In spite of the advantages which are adapted to it in particular its cost, the Charpy test does not allow to obtain directly a variable which characterizes a crack propagation resistance as for instance the toughness used for qualifying the mechanical integrity of a structure. This work deals with the establishment of the through impact strength-toughness in the transition range of the vessel steel: 16MND5 from a non-empirical approach based on the local approach of the rupture. The brittle rupture is described by the Beremin model (1983), which allows to describe the dispersion inherent in this rupture mode. The description of the brittle fissure is carried out by the GTN model (1984) and by the Rousselier model (1986). This last model has been modified in order to obtain a realistic description of the brittle damage in the case of fast solicitations and of local heating. The method proposed to determine the parameters of the damage models depends only of tests on notched specimens and of the inclusion data of the material. The behaviour is described by an original formulation parametrized in temperature which allows to describe all the tests carried out in this study. Before using this methodology, an experimental study of the behaviour and of the rupture modes of the steel 16MND5 has been carried out. From the toughness tests carried out in quasi-static and dynamical conditions, it has been revealed that this steel does not present important unwedging of its toughness curve due to the velocity effect. In the transition range, local heating of about 150 C have been measured in the root of the notch as well as plastic deformations superior to 100%. After a fractography study allowing to identify the nature of the sites which lead to the cleavage initiation, the numerical study shows, particularly, the effect of the adiabatic heating and the taking into account of the growth of cavities around a second population of particles (carbides) on the ductile fissure. The application of the proposed methodology allows to describe the resilience data until middle energies of about 70 J. Beyond, an appearing weak dependency of the cleavage constraint with temperature has to be introduced. On the other hand, the evolving of the toughness can be described until middle values of 170 MPa/m without introducing dependency of the cleavage constraint with temperature. (O.M.)

  16. Reception of Talent Shows in Denmark: First Results from a Trans-National Audience Study of a Global Format Genre

    DEFF Research Database (Denmark)

    Jensen, Pia Majbritt

    This paper will discuss the methodology and present the preliminary findings of the Danish part of a trans-national, comparative audience study of the musical talent show genre undertaken in Denmark, Finland, Germany and Great Britain in Spring 2013. Within the international business model of format adaptation, the musical talent show genre has been particularly successful in crossing cultural borders. Formats such as Idols, X Factor and Voice have sold to a large variety of countries, covering all continents. Such global reach inevitably raises the question of the genre’s audience appeal; to what degree its reach has to do with a universal appeal inherent in the genre and/or the innovative character of individual formats, and to what degree its global success is due to local broadcasters’ ability to successfully adapt the formats to local audience tastes. A consensus has developed that television formats to a considerable degree are adapted according to national audiences and, hence, national cultural tastes. And in our research approach, we do recognize that musical talent shows appear to contribute to ‘imagining the nation’ (Anderson 1983), often even mentioning the nation in the title. However, we also take into account that the national perspective needs to be considered critically. First, there are other factors but national culture that determine a local adaptation such as subnational target groups, channel identity, financing or chance incidents. Secondly, it has rightly been argued that within any national television market, especially in the post-broadcast era, a multiplicity of publics co-exists. The aim of the focus groups is therefore to shed light on the complexity of the communal viewing experience, real and imagined, national, sub-national and transnational; of identification, and of the meaning that viewers take from the musical talent show genre.

  17. Transgenic plants expressing HC-Pro show enhanced virus sensitivity while silencing of the transgene results in resistance

    OpenAIRE

    Mlotshwa, S.; Verver, J.; Sithole-niang, I.; Prins, M.; Kammen, A.; Wellink, J.

    2002-01-01

    Nicotiana benthamiana plants were engineered to express sequences of the helper component-proteinase (HC-Pro) of Cowpea aphid-borne mosaic potyvirus (CABMV). The sensitivity of the transgenic plants to infection with parental and heterologous viruses was studied. The lines expressing HC-Pro showed enhanced symptoms after infection with the parental CABMV isolate and also after infection with a heterologous potyvirus, Potato virus Y (PVY) and a comovirus, Cowpea mosaic virus (CPMV). On the oth...

  18. Presentation Showing Results of a Hydrogeochemical Investigation of the Standard Mine Vicinity, Upper Elk Creek Basin, Colorado

    Science.gov (United States)

    Manning, Andrew H.; Verplanck, Philip L.; Mast, M. Alisa; Wanty, Richard B.

    2008-01-01

    PREFACE This Open-File Report consists of a presentation given in Crested Butte, Colorado on December 13, 2007 to the Standard Mine Advisory Group. The presentation was paired with another presentation given by the Colorado Division of Reclamation, Mining, and Safety on the physical features and geology of the Standard Mine. The presentation in this Open-File Report summarizes the results and conclusions of a hydrogeochemical investigation of the Standard Mine performed by the U.S. Geological Survey (Manning and others, in press). The purpose of the investigation was to aid the U.S. Environmental Protection Agency in evaluating remediation options for the Standard Mine site. Additional details and supporting data related to the information in this presentation can be found in Manning and others (in press).

  19. Transgene silencing of the Hutchinson-Gilford progeria syndrome mutation results in a reversible bone phenotype, whereas resveratrol treatment does not show overall beneficial effects

    DEFF Research Database (Denmark)

    Strandgren, Charlotte; Nasser, Hasina Abdul

    2015-01-01

    Hutchinson-Gilford progeria syndrome (HGPS) is a rare premature aging disorder that is most commonly caused by a de novo point mutation in exon 11 of the LMNA gene, c.1824C>T, which results in an increased production of a truncated form of lamin A known as progerin. In this study, we used a mouse model to study the possibility of recovering from HGPS bone disease upon silencing of the HGPS mutation, and the potential benefits from treatment with resveratrol. We show that complete silencing of the transgenic expression of progerin normalized bone morphology and mineralization already after 7 weeks. The improvements included lower frequencies of rib fractures and callus formation, an increased number of osteocytes in remodeled bone, and normalized dentinogenesis. The beneficial effects from resveratrol treatment were less significant and to a large extent similar to mice treated with sucrose alone. However, the reversal of the dental phenotype of overgrown and laterally displaced lower incisors in HGPS mice could be attributed to resveratrol. Our results indicate that the HGPS bone defects were reversible upon suppressed transgenic expression and suggest that treatments targeting aberrant progerin splicing give hope to patients who are affected by HGPS.-Strandgren, C., Nasser, H. A., McKenna, T., Koskela, A., Tuukkanen, J., Ohlsson, C., Rozell, B., Eriksson, M. Transgene silencing of the Hutchinson-Gilford progeria syndrome mutation results in a reversible bone phenotype, whereas resveratrol treatment does not show overall beneficial effects.

  20. Thermal aging capsule results from Oconee Nuclear Station - Unit 1

    International Nuclear Information System (INIS)

    At the Oconee Nuclear Station - Unit 1 a thermal aging capsule was removed and tested at the same time a second reactor vessel surveillance capsule was removed for testing. The thermal aging capsule had received a thermal exposure of 15,000 at 580 0F (3050C) and the irradiated capsule had received an exposure of 1.5 x 1018n/cm2. The capsule contained Charpy V-notch and tension specimens of SA-302 B modified base and weld metal and SA-533 B1 correlation monitor material. The SA-302 B base metal exhibited no significant changes in Charpy V-notch impact properties as a result of thermal aging. The heat-affected-zone data indicated a drop in upper shelf properties. This drop was attributed to limited thermal aged data points and large scatter in the base data, since the notch lateral expansion and shear fracture data did not indicate the same trend. The SA-302 B weld metal exhibited a slight increase in upper shelf energy, and the SA-533 B1 correlation material exhibited a slight decrease in upper shelf energy. No tension data are reported. The conclusions of this study agree with the results reported from the Big Rock Point reactor

  1. Rapamycin and Chloroquine: The In Vitro and In Vivo Effects of Autophagy-Modifying Drugs Show Promising Results in Valosin Containing Protein Multisystem Proteinopathy

    Science.gov (United States)

    Nalbandian, Angèle; Llewellyn, Katrina J.; Nguyen, Christopher; Yazdi, Puya G.; Kimonis, Virginia E.

    2015-01-01

    Mutations in the valosin containing protein (VCP) gene cause hereditary Inclusion body myopathy (hIBM) associated with Paget disease of bone (PDB), frontotemporal dementia (FTD), more recently termed multisystem proteinopathy (MSP). Affected individuals exhibit scapular winging and die from progressive muscle weakness, and cardiac and respiratory failure, typically in their 40s to 50s. Histologically, patients show the presence of rimmed vacuoles and TAR DNA-binding protein 43 (TDP-43)-positive large ubiquitinated inclusion bodies in the muscles. We have generated a VCPR155H/+ mouse model which recapitulates the disease phenotype and impaired autophagy typically observed in patients with VCP disease. Autophagy-modifying agents, such as rapamycin and chloroquine, at pharmacological doses have previously shown to alter the autophagic flux. Herein, we report results of administration of rapamycin, a specific inhibitor of the mechanistic target of rapamycin (mTOR) signaling pathway, and chloroquine, a lysosomal inhibitor which reverses autophagy by accumulating in lysosomes, responsible for blocking autophagy in 20-month old VCPR155H/+ mice. Rapamycin-treated mice demonstrated significant improvement in muscle performance, quadriceps histological analysis, and rescue of ubiquitin, and TDP-43 pathology and defective autophagy as indicated by decreased protein expression levels of LC3-I/II, p62/SQSTM1, optineurin and inhibiting the mTORC1 substrates. Conversely, chloroquine-treated VCPR155H/+ mice revealed progressive muscle weakness, cytoplasmic accumulation of TDP-43, ubiquitin-positive inclusion bodies and increased LC3-I/II, p62/SQSTM1, and optineurin expression levels. Our in vitro patient myoblasts studies treated with rapamycin demonstrated an overall improvement in the autophagy markers. Targeting the mTOR pathway ameliorates an increasing list of disorders, and these findings suggest that VCP disease and related neurodegenerative multisystem proteinopathies can now be included as disorders that can potentially be ameliorated by rapalogs. PMID:25884947

  2. The mammalian alcohol dehydrogenase genome shows several gene duplications and gene losses resulting in a large set of different enzymes including pseudoenzymes.

    Science.gov (United States)

    Östberg, Linus J; Persson, Bengt; Höög, Jan-Olov

    2015-06-01

    Mammalian alcohol dehydrogenase (ADH) is a protein family divided into six classes and the number of known family members is increasing rapidly. Several primate genomes are completely analyzed for the ADH region, where higher primates (human and hominoids) have seven genes of classes ADH1-ADH5. Within the group of non-hominoids apes there have been further duplications and species with more than the typical three isozymic forms for ADH1 are present. In contrast there are few completely analyzed ADH genomes in the non-primate group of mammals, where an additional class has been identified, ADH6, that has been lost during the evolution of primates. In this study 85 mammalian genomes with at least one ADH gene have been compiled. In total more than 500 ADH amino acid sequences were analyzed for patterns that distinguish the different classes. For ADH1-ADH4 intensive investigations have been performed both at the functional and at structural levels. However, a corresponding functional protein to the ADH5 gene, which is found in most ADH genomes, has never been detected. The same is true for ADH6, which is only present in non-primates. The entire mammalian ADH family shows a broad spectrum of gene duplications and gene losses where the numbers differ from six genes (most non-primate mammals) up to ten genes (vole). Included in these sets are examples of pseudogenes and pseudoenzymes. PMID:25479062

  3. 46 CFR 54.05-20 - Impact test properties for service of 0 °F and below.

    Science.gov (United States)

    2010-10-01

    ... COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) MARINE ENGINEERING PRESSURE VESSELS Toughness Tests § 54.05-20...suitable correlation of Charpy V-notch results with drop-weight NDT or no-break performance, Charpy V-notch tests...

  4. Television Quiz Show Simulation

    Science.gov (United States)

    Hill, Jonnie Lynn

    2007-01-01

    This article explores the simulation of four television quiz shows for students in China studying English as a foreign language (EFL). It discusses the adaptation and implementation of television quiz shows and how the students reacted to them.

  5. Showing Value (Editorial

    Directory of Open Access Journals (Sweden)

    Denise Koufogiannakis

    2009-06-01

    Full Text Available When Su Cleyle and I first decided to start Evidence Based Library and Information Practice, one of the things we agreed upon immediately was that the journal be open access. We knew that a major obstacle to librarians using the research literature was that they did not have access to the research literature. Although Su and I are both academic librarians who can access a wide variety of library and information literature from our institutions, we belong to a profession where not everyone has equal access to the research in our field. Without such access to our own body of literature, how can we ever hope for practitioners to use research evidence in their decision making? It would have been contradictory to the principles of evidence based library and information practice to do otherwise.One of the specific groups we thought could use such an open access venue for discovering research literature was school librarians. School librarians are often isolated and lacking access to the research literature that may help them prove to stakeholders the importance of their libraries and their role within schools. Certainly, school libraries have been in decline and the use of evidence to show value is needed. As Ken Haycock noted in his 2003 report, The Crisis in Canada’s School Libraries: The Case for Reform and Reinvestment, “Across the country, teacher-librarians are losing their jobs or being reassigned. Collections are becoming depleted owing to budget cuts. Some principals believe that in the age of the Internet and the classroom workstation, the school library is an artifact” (9. Within this context, school librarians are looking to our research literature for evidence of the impact that school library programs have on learning outcomes and student success. They are integrating that evidence into their practice, and reflecting upon what can be improved locally. They are focusing on students and showing the impact of school libraries and librarians on student achievement. Todd notes, “If we do not show value, we will not have a future. Evidence-based practice is not about the survival of school librarians, it’s about the survival of our students” (40. In this issue we feature school libraries and their connection to evidence based practice. Former Editor-in-Chief, Lindsay Glynn, began putting the wheels in motion for this feature almost a year ago. She invited Carol Gordon and Ross Todd to act as guest editors of the section, drawing upon their contacts and previous work in this field. The result is an issue with five feature articles exploring different aspects of the connection between school libraries and evidence based practice, from the theoretical to the practical. In addition, there is a thought-provoking Commentary by David Loertscher, asking whether we need the evolutionary model of evidence based practice, or something more revolutionary!In addition to the Feature section, we have a well-rounded issue with articles on the topics of library human resources, and the development of a scholars’ portal. As well, there are a record 10 evidence summaries and our educational EBL101 column. I hope there is something for everyone in this issue of EBLIP – enjoy, and see you soon in Stockholm!

  6. Homemade Laser Show

    Science.gov (United States)

    Children's Museum of Houston

    2011-01-01

    With a laser pointer and some household items, learners can create their own laser light show. They can explore diffuse reflection, refraction and diffraction. The webpage includes a video which shows how to set up the activity and also includes scientific explanation. Because this activity involves lasers, it requires adult supervision.

  7. The Diane Rehm Show

    Science.gov (United States)

    The Diane Rehm Show has its origins in a mid-day program at WAMU in Washington, D.C. Diane Rehm came on to host the program in 1979, and in 1984 it was renamed "The Diane Rehm Show". Over the past several decades, Rehm has played host to hundreds of guests, include Archbishop Desmond Tutu, Julie Andrews, and President Bill Clinton. This website contains an archive of her past programs, and visitors can use the interactive calendar to look through past shows. Those visitors looking for specific topics can use the "Topics" list on the left-hand side of the page, or also take advantage of the search engine. The show has a number of social networking links, including a Facebook page and a Twitter feed.

  8. A Holographic Road Show.

    Science.gov (United States)

    Kirkpatrick, Larry D.; Rugheimer, Mac

    1979-01-01

    Describes the viewing sessions and the holograms of a holographic road show. The traveling exhibits, believed to stimulate interest in physics, include a wide variety of holograms and demonstrate several physical principles. (GA)

  9. Demonstration Road Show

    Science.gov (United States)

    2009-04-06

    The Idaho State University Department of Physics conducts science demonstration shows at S. E. Idaho schools. Four different presentations are currently available; "Forces and Motion", "States of Matter", "Electricity and Magnetism", and "Sound and Waves". Information provided includes descriptions of the material and links to other resources.

  10. Obesity in show cats.

    Science.gov (United States)

    Corbee, R J

    2014-12-01

    Obesity is an important disease with a high prevalence in cats. Because obesity is related to several other diseases, it is important to identify the population at risk. Several risk factors for obesity have been described in the literature. A higher incidence of obesity in certain cat breeds has been suggested. The aim of this study was to determine whether obesity occurs more often in certain breeds. The second aim was to relate the increased prevalence of obesity in certain breeds to the official standards of that breed. To this end, 268 cats of 22 different breeds investigated by determining their body condition score (BCS) on a nine-point scale by inspection and palpation, at two different cat shows. Overall, 45.5% of the show cats had a BCS > 5, and 4.5% of the show cats had a BCS > 7. There were significant differences between breeds, which could be related to the breed standards. Most overweight and obese cats were in the neutered group. It warrants firm discussions with breeders and cat show judges to come to different interpretations of the standards in order to prevent overweight conditions in certain breeds from being the standard of beauty. Neutering predisposes for obesity and requires early nutritional intervention to prevent obese conditions. PMID:24612018

  11. Blue Ribbon Art Show.

    Science.gov (United States)

    Bowen, Judy Domeny

    2002-01-01

    Describes the process of selecting judges for a Blue Ribbon Art Show (Springfield, Missouri). Used adults (teachers, custodians, professional artists, parents, and principals) chosen by the Willard South Elementary School art teacher to judge student artwork. States that nominated students received blue ribbons. (CMK)

  12. Honored Teacher Shows Commitment.

    Science.gov (United States)

    Ratte, Kathy

    1987-01-01

    Part of the acceptance speech of the 1985 National Council for the Social Studies Teacher of the Year, this article describes the censorship experience of this honored social studies teacher. The incident involved the showing of a videotape version of the feature film entitled "The Seduction of Joe Tynan." (JDH)

  13. The Graphing Game Show

    Science.gov (United States)

    2011-01-01

    This lesson plan assesses student interpretation of graphs utilizing cooperative learning to further students understanding. Types of graphs used are horizontal and vertical bar graphs, picture graphs, and pictographs. In the lesson students play a game called the Graphing Game Show, in which they must work as a team to answer questions about specific graphs. The lesson includes four student resource worksheets and suggestions for extension and differentiation.

  14. Reality, ficción o show

    Directory of Open Access Journals (Sweden)

    Sandra Ru\\u00EDz Moreno

    2002-01-01

    Full Text Available Para tener un punto de vista claro y objetivo frente a la polémica establecida en torno al programa ?Protagonistas de novela? y la tendiente proliferación de los reality show en las parrillas de programación de la televisión colombiana, se realizó un análisis de texto y contenido de dicho programa, intentando definirlo desde sus posibilidades de realidad, ficción y show. Las unidades de análisis y el estudio de su tratamiento arrojaron un alto contenido que gira en torno a las emociones del ser humano relacionadas con la convivencia, tratadas a manera de show y con algunos aportes textuales de ficción, pero sin su elemento mediador básico, el actor, quitándole toda la posibilidad de tener un tratamiento con la profundidad, distancia y ética que requieren los temas de esta índole. El resultado es un formato que sólo busca altos índices de sintonía y que pertenece más a la denominada televisión ?trash?, que a una búsqueda de realidad del hombre y mucho menos de sociedad.

  15. Obesity in show dogs.

    Science.gov (United States)

    Corbee, R J

    2012-08-11

    Obesity is an important disease with a growing incidence. Because obesity is related to several other diseases, and decreases life span, it is important to identify the population at risk. Several risk factors for obesity have been described in the literature. A higher incidence of obesity in certain breeds is often suggested. The aim of this study was to determine whether obesity occurs more often in certain breeds. The second aim was to relate the increased prevalence of obesity in certain breeds to the official standards of that breed. To this end, we investigated 1379 dogs of 128 different breeds by determining their body condition score (BCS). Overall, 18.6% of the show dogs had a BCS >5, and 1.1% of the show dogs had a BCS>7. There were significant differences between breeds, which could be correlated to the breed standards. It warrants firm discussions with breeders and judges in order to come to different interpretations of the standards to prevent overweight conditions from being the standard of beauty. PMID:22882163

  16. Experimental Psoriasis Drug Shows Promise

    Science.gov (United States)

    Experimental Psoriasis Drug Shows Promise Guselkumab appears more effective than standard treatment, researchers report To use the sharing features ... News) -- Preliminary trial results suggest that an experimental psoriasis drug may control the chronic skin disease better ...

  17. Egg: the Arts Show

    Science.gov (United States)

    "Egg is a new TV show about people making art across America" from PBS. This accompanying Website presents excerpts from sixteen episodes of the series, with three more "hatching soon," such as Close to Home, profiling three photographers: Jeanine Pohlhaus, whose pictures document her father's struggle with mental illness; Gregory Crewdson's photos of Lee, Massachusetts; and Joseph Rodriguez's photos of Hispanics in New York City. Excerpts include video clips, gallery listings where the artists' work can be seen, and short interviews with artists. Some episodes also offer "peeps," glimpses of material not shown on TV, such as the Space episode's peep, Shooting Stars, that provides directions for astrophotography, taking photographs of star trails. Other sections of the site are airdates, for local listings; see and do usa, where vacationers can search for art events at their destinations; and egg on the arts, a discussion forum.

  18. Results of crack-arrest tests on irradiated a 508 class 3 steel

    International Nuclear Information System (INIS)

    Ten crack-arrest toughness values for irradiated specimens of A 508 class 3 forging steel have been obtained. The tests were performed according to the American Society for Testing and Materials (ASTM) Standard Test Method for Determining Plane-Strain Crack-Arrest Fracture Toughness, Kla of Ferritic Steels, E 1221-88. None of these values are strictly valid in all five ASTM E 1221-88 validity criteria. However, they are useful when compared to unirradiated crack-arrest specimen toughness values since they show the small (averaging approximately 10 degrees C) shifts in the mean and lower-bound crack-arrest toughness curves. This confirms that a low copper content in ASTM A 508 class 3 forging material can be expected to result in small shifts of the transition toughness curve. The shifts due to neutron irradiation of the lower bound and mean toughness curves are approximately the same as the Charpy V-notch (CVN) 41-J temperature shift. The nine crack-arrest specimens were irradiated at temperatures varying from 243 to 280 degrees C, and to a fluence varying from 1.7 to 2.7 x 1019 neutrons/cm2 (> 1 MeV). The test results were normalized to reference values that correspond to those of CVN specimens irradiated at 284 degrees C to a fluence of 3.2 x 1019 neutrons/cm2 (> 1 MeV) in the same capsule as the crack-arrest specimens. This adjustment resulted in a shift to lower temperatures of all the data, and in particular moved two data points that appeared to lie close to or lower than the American Society of Mechanical Engineers Kla curve to positions that seemed more reasonable with respect to the remaining data. A special fixture was designed, fabricated, and successfully used in the testing. For reasons explained in the text, special blocks to receive the Oak Ridge National Laboratory clip gage were designed, and greater-than-standard crack-mouth opening displacements measured were accounted for. 24 refs., 13 figs., 12 tabs

  19. Charpy impact test results on five materials and NIST verification specimens using instrumented 2-mm and 8-mm strikers

    International Nuclear Information System (INIS)

    The Heavy-Section Steel Irradiation Program at Oak Ridge National Laboratory is involved in two cooperative projects, with international participants, both of which involve Charpy V-notch impact tests with instrumented strikers of 2mm and 8mm radii. Two heats of A 533 grade B class I pressure vessel steel and a low upper-shelf (LUS) submerged-arc (SA) weld were tested on the same Charpy machine, while one heat of a Russian Cr-Mo-V forging steel and a high upper-shelf (HUS) SA weld were tested on two different machines. The number of replicate tests at any one temperature ranged from 2 to 46 specimens. Prior to testing with each striker, verification specimens at the low, high, and super high energy levels from the National Institute of Standards and Technology (NIST) were tested. In the two series of verification tests, the tests with the 2mm striker met the requirements at the low and high energy levels but not at the super high energy. For one plate, the 2mm striker showed somewhat higher average absorbed energies than those for the 8-mm striker at all three test temperatures. For the second plate and the LUS weld, however, the 2mm striker showed somewhat lower energies at both test temperatures. For the Russian forging steel and the HUS weld, tests were conducted over a range of temperatures with tests at one laboratory using the 8mm striker and tests at a second laboratory using the 2mm striker. Lateral expansion was measured for all specimens and the results are compared with the absorbed energy results. The overall results showed generally good agreement (within one standard deviation) in energy measurements by the two strikers. Load-time traces from the instrumented strikers were also compared and used to estimate shear fracture percentage. Four different formulas from the European Structural Integrity Society draft standard for instrumented Charpy test are compared and a new formula is proposed for estimation of percent shear from the force-time trace

  20. Dietary fiber showed no preventive effect against colon and rectal cancers in Japanese with low fat intake: an analysis from the results of nutrition surveys from 23 Japanese prefectures

    Directory of Open Access Journals (Sweden)

    Sugawara Kazuo

    2001-10-01

    Full Text Available Abstract Background Since Fuchs' report in 1999, the reported protective effect of dietary fiber from colorectal carcinogenesis has led many researchers to question its real benefit. The aim of this study is to evaluate the association between diet, especially dietary fiber and fat and colorectal cancer in Japan. Methods A multiple regression analysis (using the stepwise variable selection method was performed using the standardized mortality ratios (SMRs of colon and rectal cancer in 23 Japanese prefectures as objective variables and dietary fiber, nutrients and food groups as explanatory variables. Results As for colon cancer, the standardized partial correlation coefficients were positively significant for fat (1,13, P = 0.000, seaweeds (0.41, P = 0.026 and beans (0.45, P = 0.017 and were negatively significant for vitamin A (-0.63, P = 0.003, vitamin C (-0.42, P = 0.019 and yellow-green vegetables (-0.37, P = 0.046. For rectal cancer, the standardized partial correlation coefficient in fat (0.60, P = 0.002 was positively significant. Dietary fiber was not found to have a significant relationship with either colon or rectal cancers. Conclusions This study failed to show any protective effect of dietary fiber in subjects with a low fat intake (Japanese in this analysis, which supports Fuchs' findings in subjects with a high fat intake (US Americans.

  1. TAPS pressure vessel surveillance - results and evaluation

    International Nuclear Information System (INIS)

    SA302B (nickel modified) steel cladded with stainless steel is used as the pressure vessel material for the two 210 MWe boiling water reactors of the Tarapur Atomic Power Station. Charpy V-notch impact surveillance specimens representing the pressure vessel belt-line base, weld and the heat affected zone were irradiated at the wall and shroud locations. Some of these specimens were removed after 6.5 effective full power years (EFPY) of reactor operation. The neutron fluences at the locations were 5.31 x 1017 and 4.88 x 1018 n/cm2 (E > 1 MeV). The surveillance data generated from specimens removed after 6.5 EFPY were evaluated on the basis of USNRC Regulatory Guide 1.99, Revision 2, and the results had assured the integrity of the vessel beyond the end of design service life (EOL) of 40 years. The recent evaluation of the additional data generated from specimens removed after 13 EFPY has again confirmed the safety of the pressure vessel beyond EOL by an additional 20 EFPY. (author)

  2. Applications of surveillance programme results to reactor pressure vessel integrity assessment. Results of a coordinated research project 2000-2004

    International Nuclear Information System (INIS)

    This TECDOC has been developed under an IAEA Coordinated Research Project (CRP) on Surveillance Programme Results Application to Reactor Pressure Vessel Integrity Assessment. This CRP is the fifth in a series that have led to the defining of the most appropriate fracture toughness parameters (using relatively small test specimens) for ensuring structural integrity of reactor pressure vessel (RPV) materials. The CRP group consisted of 20 testing laboratories representing 15 Member States. The CRP had three main objectives: (1) to develop a large database of fracture toughness data using the Master Curve methodology for both precracked Charpy-sized specimens and one-inch thick (25.4 mm) compact tension (1T-CT) specimens, (2) to assess possible specimen bias effects and any effects of the range of temperatures used to determine T0, either using the single temperature or multi-temperature assessment methods, and (3) to develop international guidelines for measuring and applying Master Curve fracture toughness results for RPV integrity assessment. Fracture toughness test results showed clear evidence that lower values of unirradiated T0 were obtained using precracked Charpy specimens compared with results obtained from 1T-CT specimens. This bias in test results is very important when considering the use of precracked Charpy specimens for evaluating RPV integrity. In fact, this is a technical area where the results from this CRP were influential in changing the ASTM test method to include consideration of this effect. The direct measurement approach using the Master Curve approach for RPV structural integrity assessment has distinct advantages over the indirect methods used in the past for assessing radiation embrittlement effects. The Master Curve methodology already has been or is being assimilated into the ASME Boiler and Pressure Vessel Code, ASTM Standards, USNRC Regulations, German Regulations (KTA 3203), IAEA pressurized thermal shock guidelines for WWER reactors as well as the unified procedure for WWER component lifetime assessment and other industry guidance documents governing RPV integrity analysis. This report was written to allow nuclear utility engineers and industry scientists to directly measure fracture toughness using small surveillance size specimens of irradiated reactor pressure vessel steels and directly apply the results using the Master Curve approach for RPV structural integrity assessment. This report provides a summary of Master Curve fracture toughness test results on small surveillance type specimens of the IAEA Reference Material JRQ and other national steels from numerous laboratories throughout the world. In addition to transition temperature testing using Charpy V-notch test specimens, some emphasis was placed on using tensile and early-design fracture toughness test specimens applying elastic-plastic fracture mechanics methods. Further progress in the application of fracture mechanics analysis methods for radiation damage assessment was achieved in this phase. Improvement and unification of neutron dosimetry methods provided better data with less inherent scatter. All results together with their analyses and raw data were summarized in IAEA Technical Reports Series No. 265

  3. Women show worse control of type 2 diabetes and cardiovascular disease risk factors than men: Results from the MIND.IT Study Group of the Italian Society of Diabetology.

    OpenAIRE

    Trovati, Mariella

    2013-01-01

    BACKGROUND AND AIMS: The study explores the degree of control of hyperglycaemia and cardiovascular (CV) disease risk factors in men and women with type 2 diabetes and the impact thereon of obesity, central adiposity, age and use of medications. METHODS AND RESULTS: A cross-sectional survey was conducted at 10 hospital-based outpatients diabetes clinics. 1297 men and 1168 women with no previous CV events were studied. Women were slightly (only one year) older and more obese than men: ...

  4. The "Life Potential": a new complex algorithm to assess "Heart Rate Variability" from Holter records for cognitive and diagnostic aims. Preliminary experimental results showing its dependence on age, gender and health conditions

    CERN Document Server

    Barra, Orazio A

    2013-01-01

    Although HRV (Heart Rate Variability) analyses have been carried out for several decades, several limiting factors still make these analyses useless from a clinical point of view. The present paper aims at overcoming some of these limits by introducing the "Life Potential" (BMP), a new mathematical algorithm which seems to exhibit surprising cognitive and predictive capabilities. BMP is defined as a linear combination of five HRV Non-Linear Variables, in turn derived from the thermodynamic formalism of chaotic dynamic systems. The paper presents experimental measurements of BMP (Average Values and Standard Deviations) derived from 1048 Holter tests, matched in age and gender, including a control group of 356 healthy subjects. The main results are: (a) BMP always decreases when the age increases, and its dependence on age and gender is well established; (b) the shape of the age dependence within "healthy people" is different from that found in the general group: this behavior provides evidence of possible illn...

  5. New Drug Shows Mixed Results Against Early Alzheimer's

    Science.gov (United States)

    ... to Alzheimer’s Treatment Can Licorice Boost Brain Power? Cancer-Alzheimer’s Link to Be Explored Study of New Alzheimer’s Drug, Namenda, Expands Snoezelen Rooms May Offer Benefits for those with Dementia ...

  6. Risk Aversion in Game Shows

    DEFF Research Database (Denmark)

    Andersen, Steffen; Harrison, Glenn W.

    2008-01-01

    We review the use of behavior from television game shows to infer risk attitudes. These shows provide evidence when contestants are making decisions over very large stakes, and in a replicated, structured way. Inferences are generally confounded by the subjective assessment of skill in some games, and the dynamic nature of the task in most games. We consider the game shows Card Sharks, Jeopardy!, Lingo, and finally Deal Or No Deal. We provide a detailed case study of the analyses of Deal Or No Deal, since it is suitable for inference about risk attitudes and has attracted considerable attention.

  7. What Do Blood Tests Show?

    Science.gov (United States)

    ... doctor about values on blood tests for children. Complete Blood Count The table below shows some normal ranges for different parts of the complete blood count (CBC) test. Some of the normal ranges differ ...

  8. Tokyo Motor Show 2003; Tokyo Motor Show 2003

    Energy Technology Data Exchange (ETDEWEB)

    Joly, E.

    2004-01-01

    The text which follows present the different techniques exposed during the 37. Tokyo Motor Show. The report points out the great tendencies of developments of the Japanese automobile industry. The hybrid electric-powered vehicles or those equipped with fuel cells have been highlighted by the Japanese manufacturers which allow considerable budgets in the research of less polluting vehicles. The exposed models, although being all different according to the manufacturer, use always a hybrid system: fuel cell/battery. The manufacturers have stressed too on the intelligent systems for navigation and safety as well as on the design and comfort. (O.M.)

  9. Numerical modelling of Charpy-V notch test by local approach to fracture. Application to an A508 steel in the ductile-brittle transition range; Modelisation de l'essai Charpy par l'approche locale de la rupture. Application au cas de l'acier 16MND5 dans le domaine de transition

    Energy Technology Data Exchange (ETDEWEB)

    Tanguy, B

    2001-07-15

    Ferritic steels present a transition of the rupture mode which goes progressively of a brittle rupture (cleavage) to a ductile rupture when the temperature increases. The following of the difference of the transition temperature of the PWR vessel steel by the establishment of toughness curves makes of the Charpy test an integrating part of the monitoring of the French PWR reactors. In spite of the advantages which are adapted to it in particular its cost, the Charpy test does not allow to obtain directly a variable which characterizes a crack propagation resistance as for instance the toughness used for qualifying the mechanical integrity of a structure. This work deals with the establishment of the through impact strength-toughness in the transition range of the vessel steel: 16MND5 from a non-empirical approach based on the local approach of the rupture. The brittle rupture is described by the Beremin model (1983), which allows to describe the dispersion inherent in this rupture mode. The description of the brittle fissure is carried out by the GTN model (1984) and by the Rousselier model (1986). This last model has been modified in order to obtain a realistic description of the brittle damage in the case of fast solicitations and of local heating. The method proposed to determine the parameters of the damage models depends only of tests on notched specimens and of the inclusion data of the material. The behaviour is described by an original formulation parametrized in temperature which allows to describe all the tests carried out in this study. Before using this methodology, an experimental study of the behaviour and of the rupture modes of the steel 16MND5 has been carried out. From the toughness tests carried out in quasi-static and dynamical conditions, it has been revealed that this steel does not present important unwedging of its toughness curve due to the velocity effect. In the transition range, local heating of about 150 C have been measured in the root of the notch as well as plastic deformations superior to 100%. After a fractography study allowing to identify the nature of the sites which lead to the cleavage initiation, the numerical study shows, particularly, the effect of the adiabatic heating and the taking into account of the growth of cavities around a second population of particles (carbides) on the ductile fissure. The application of the proposed methodology allows to describe the resilience data until middle energies of about 70 J. Beyond, an appearing weak dependency of the cleavage constraint with temperature has to be introduced. On the other hand, the evolving of the toughness can be described until middle values of 170 MPa/m without introducing dependency of the cleavage constraint with temperature. (O.M.)

  10. Magic Carpet Shows Its Colors

    Science.gov (United States)

    2004-01-01

    The upper left image in this display is from the panoramic camera on the Mars Exploration Rover Spirit, showing the 'Magic Carpet' region near the rover at Gusev Crater, Mars, on Sol 7, the seventh martian day of its journey (Jan. 10, 2004). The lower image, also from the panoramic camera, is a monochrome (single filter) image of a rock in the 'Magic Carpet' area. Note that colored portions of the rock correlate with extracted spectra shown in the plot to the side. Four different types of materials are shown: the rock itself, the soil in front of the rock, some brighter soil on top of the rock, and some dust that has collected in small recesses on the rock face ('spots'). Each color on the spectra matches a line on the graph, showing how the panoramic camera's different colored filters are used to broadly assess the varying mineral compositions of martian rocks and soils.

  11. Rocks and Minerals Slide Show

    Science.gov (United States)

    This interactive slide show of common rocks and minerals allows students to choose from two sets of minerals and click on a thumbnail to see a larger photograph with a full description of the mineral including color, streak, hardness, cleavage/fracture, and chemical composition. Also included are its use and where it is found. The rocks are divided into igneous, sedimentary, and metamorphic and can be accessed in the same manner. They are described on the basis of crystal size and mineral composition as well as use.

  12. Stability criterion of V-notched bodies under combined mode of loading.

    Czech Academy of Sciences Publication Activity Database

    Klusák, Jan

    Gliwice : Politechnika Slaska Katedra Mechaniki Stosowanej, 2003 - (Mezyk, E.; Switonski, E.; Tejszerska, D.; Gzik, B.; Jureczko, P.; Manka, I.; Marcinkowska, M.), s. 135-142 - ( Zeszyty naukowe katedry mechaniki stosowanej.. 21). [Applied mechanics 2003. Jaworzynka (CZ), 24.03.2003-27.03.2003] R&D Projects: GA ?R GP106/03/P054 Institutional research plan: CEZ:AV0Z2041904 Keywords : notch * stability criterion * combined loading Subject RIV: JL - Materials Fatigue, Friction Mechanics

  13. Experimental evaluation of strain fields in the vicinity of V-notch in ductile metal.

    Czech Academy of Sciences Publication Activity Database

    Jandejsek, Ivan; Jiroušek, Ond?ej; Vav?ík, Daniel

    Praha : ?VUT, 2012 - (Plachý, P.; Padev?t, P.; Tesárek, P.; Stránský, J.; Zobal, O.), s. 89-94 ISBN 978-80-01-05097-2. [Nano and Macro mechanics 2012 /3./. Praha (CZ), 20.09.2012] R&D Projects: GA ?R(CZ) GA103/09/2101 Institutional support: RVO:68378297 Keywords : strain /stress measurement * digital image correlation * fracture mechanics Subject RIV: JL - Materials Fatigue, Friction Mechanics

  14. Results, Results, Results?

    Science.gov (United States)

    Wallace, Dale

    2000-01-01

    Given the amount of time, energy, and money devoted to provincial achievement exams in Canada, it is disturbing that Alberta students and teachers feel so pressured and that the exams do not accurately reflect what students know. Research shows that intelligence has an (untested) emotional component. (MLH)

  15. Olaparib shows promise in multiple tumor types.

    Science.gov (United States)

    2013-07-01

    A phase II study of the PARP inhibitor olaparib (AstraZeneca) for cancer patients with inherited BRCA1 and BRCA2 gene mutations confirmed earlier results showing clinical benefit for advanced breast and ovarian cancers, and demonstrated evidence of effectiveness against pancreatic and prostate cancers. PMID:23847380

  16. Results of examinations of pressure vessel samples and instrument nozzles from the TMI-2 lower head

    International Nuclear Information System (INIS)

    Fifteen prism-shaped steel samples were removed from the lower head of the damaged TMI-2 reactor pressure vessel to assess the effects of approximately 19 metric tons of molten core debris that had relocated there during the 1979 loss-of-coolant accident. Metallographic examinations of the samples revealed that inside surface temperatures of 800 to 1,100 degree C were attained during the accident in an elliptical shaped ''hot spot'' ?1 x 0.7 m. Tensile, creep, and Charpy V-notch specimens were also cut from the samples to assess the mechanical properties of the lower head material at temperatures up to the peak accident temperature. These properties were used in a margin to failure analysis of the lower head. Examinations of instrument nozzles removed from the lower head region assisted in defining the relocation scenario of the molten core debris and showed that the lower head was largely protected from catastrophic failure by a solidified layer around the molten core debris that acted as a partial thermal insulator

  17. Pectin shows antibacterial activity against Helicobacter pylori

    Directory of Open Access Journals (Sweden)

    Roula M. Abdel-Massih

    2013-02-01

    Full Text Available Pectins are the collective name for a group of heterogeneous, high molecular weight, branched polysaccharides that are found in the cell walls of higher plants. In this study, we intend to determine the antibacterial activity of pectin against reference strains and clinical isolates of Helicobacter pylori. The results show that pectin produced antibacterial effects on all the 16 clinical isolates and 2 reference strains of H. pylori with the greatest antibacterial effect at a low pH (5.0 versus higher pHs. The lowest Minimum Inhibitory Concentration recorded was of 0.016 ?g/?l. Antibiotic resistance, therapy costs, and undesirable side effects stress the need for new antimicrobials or alternative therapies. The results from our study can further our goal of future eradication of H. pylori infection using new molecules.

  18. New Drug Shows Promise Against Psoriasis

    Science.gov (United States)

    ... fullstory_153105.html New Drug Shows Promise Against Psoriasis Ixekizumab appeared to outperform standard medication in a ... HealthDay News) -- Many patients with the skin disease psoriasis showed significant improvement when taking an experimental drug ...

  19. Solar System Odyssey - Fulldome Digital Planetarium Show

    Science.gov (United States)

    This is a Fulldome Digital Planetarium Show. Learners go on a futuristic journey through our Solar System. They explore the inner and outer planets, then the moons: Titan, Europa, and Callisto as possible places to establish a human colony. A full-length preview of the show is available on the website, you need to scroll down about 3/4 of the page - under section on children's shows, direct link not available.

  20. UV Photography Shows Hidden Sun Damage

    Science.gov (United States)

    ... us a safe way to see how the sun damages our skin. In the UV photos that appear below on ... right) shows he does not have sun-damaged skin. Normal photography UV photography 4 years of age : Early sun damage starts to show. Notice the freckling across his ...

  1. Resultados histológicos e detecção do HPV em mulheres com células escamosas atípicas de significado indeterminado e lesão escamosa intra-epitelial de baixo grau na colpocitologia oncológica / Histological results and HPV detection in women with pap smear showing atypical squamous cells of undetermined significance and low-grade squamous intraepithelial lesion

    Scientific Electronic Library Online (English)

    André Luis Ferreira, Santos; Sophie Françoise Mauricette, Derchain; Luis Otávio, Sarian; Elizabete Aparecida, Campos; Marcos Roberto dos, Santos; Gislaine Aparecida, Fonsechi-Carvasan.

    2004-07-01

    Full Text Available OBJETIVOS: avaliar o desempenho da colpocitologia oncológica (CO) e da Captura de Híbridos II (CHII) para o diagnóstico de lesão cervical histológica significativa (NIC2/3) em mulheres encaminhadas com CO contendo atipias celulares de significado indeterminado (ASCUS) ou lesão escamosa intra-epiteli [...] al de baixo grau (LSIL). MÉTODOS: estudo de corte transversal no qual foram incluídas 161 mulheres encaminhadas, entre agosto de 2000 e setembro de 2002, devido a CO com resultado de ASCUS ou LSIL. As mulheres responderam a questionário específico sobre características sociodemográficas e reprodutivas e foram submetidas a exame ginecológico com coleta de CO e CHII, sendo realizada colposcopia com eventual biópsia de áreas suspeitas. Foi aplicado o teste do qui-quadrado para as associações da idade, uso de condom, uso de anticoncepcional oral e tabagismo com os resultados da CHII. Foram calculados a sensibilidade, especificidade, valor preditivo positivo e valor preditivo negativo da CO e da CHII para detectar NIC2/3. Todos os cálculos foram realizados com intervalos de confiança estatística de 95%. RESULTADOS: sessenta e sete porcento das mulheres com menos de 30 anos de idade tiveram testes positivos para o HPV. A CO e CHII tiveram sensibilidade de 82% em detectar NIC2/3 quando considerados como positivos ASCUS, LSIL ou HSIL. Quando se consideram como positivas apenas as CO com HSIL, este exame apresenta acentuado ganho de especificidade (de 29 para 95%) e valor preditivo positivo (de 12 para 50%), superando a CHII, porém com redução igualmente significativa de sua sensibilidade (de 82 para 41%). CONCLUSÕES: nossos resultados indicaram grande potencial da CHII para detectar mulheres com NIC2/3 entre as pacientes com ASCUS/LSIL na CO de encaminhamento. Abstract in english OBJECTIVE: to assess the ability of Pap smear and hybrid capture II (HCII) to detect clinically significant cervical lesions (CIN2/3) in women referred to hospital due to atypical squamous cells of unknown significance (ASCUS) or low-grade squamous intraepithelial lesions (LSIL). METHODS: a cross-se [...] ctional study comprising 161 women referred to the Taubaté University Hospital due to ASCUS/LSIL, between August 2000 and September 2002. All women responded to a questionnaire regarding sociodemographic and reproductive characteristics and were subjected to gynecological examination with specimen collection for Pap test and HCII, along with colposcopy and eventual cervical biopsy. The relationship between HCII results and age, use of condom, oral hormonal contraception, and smoking were evaluated by the chi-square test. The sensitivity, specificity, positive and negative predictive values of both Pap test and HCII were calculated. All calculations were performed within 95% confidence intervals. RESULTS: sixty-seven percent of the women that tested positive for HPV were less than 30 years old. Pap smear and HCII showed the same 82% sensitivity in detecting CIN2/3 when the threshold for a positive Pap result was ASCUS, LSIL or HSIL. Pap smear specificity and positive predictive values were substantially increased when only HSIL results were considered as positive (from 29 to 95% and 12 to 50%, respectively). These figures were superior to those of HCII, but at the expense of an expressive loss of sensitivity (from 82% to 41%). CONCLUSIONS: our results substantiate the potential of HCII in detecting CIN2/3 among women referred due to ASCUS/LSIL.

  2. Comparison of Weather Shows in Eastern Europe

    Science.gov (United States)

    Najman, M.

    2009-09-01

    Comparison of Weather Shows in Eastern Europe Television weather shows in Eastern Europe have in most cases in the high graphical standard. There is though a wast difference in duration and information content in the weather shows. There are few signs and regularities by which we can see the character of the weather show. The main differences are mainly caused by the income structure of the TV station. Either it is a fully privately funded TV relying on the TV commercials income. Or it is a public service TV station funded mainly by the national budget or fixed fee structure/tax. There are wast differences in duration and even a graphical presentation of the weather. Next important aspect is a supplier of the weather information and /or the processor. Shortly we can say, that when the TV show is produced by the national met office, the TV show consists of more scientific terms, synoptic maps, satellite imagery, etc. If the supplier is the private meteorological company, the weather show is more user-friendly, laical with less scientific terms. We are experiencing a massive shift in public weather knowledge and demand for information. In the past, weather shows consisted only of maps with weather icons. In todaýs world, even the laic weather shows consist partly of numerical weather model outputs - they are of course designed to be understandable and graphically attractive. Outputs of the numerical weather models used to be only a part of daily life of a professional meteorologist, today they are common part of life of regular people. Video samples are a part of this presentation.

  3. Voyeurismo Televisivo, Reality Shows e Brasilidade Televisiva

    Directory of Open Access Journals (Sweden)

    Suzana Kilpp

    2008-12-01

    Full Text Available In the last years we watched a boom of reality shows in the media and also in the academic production specialized in this subject. It remains, however, a epistemological gap related to the aesthetic and techniques (which are related to the televisions grammars that TV uses in these programs to enunciate ethics directions to its own voyeurism, that goes far beyond reality shows, having repercussions on social imaginary of transparency and surveillance, and the redesign of public and private spaces. In this gap, the article points out the debate of Brazilian reality shows in the perspective of the televisions grammars.

  4. Ebola Treatment Shows Promise in Monkey Study

    Science.gov (United States)

    Ebola Treatment Shows Promise in Monkey Study Antiviral drug cured animals with advanced infections, researchers say To ... HealthDay News) -- An experimental drug being tested on Ebola victims in Sierra Leone has proven effective in ...

  5. Freshwater Algae Can Infect Wounds, Study Shows

    Science.gov (United States)

    Freshwater Algae Can Infect Wounds, Study Shows Two cases appear linked to a species in U.S. lakes, but researchers ... and Texas are giving insight into a freshwater algae that can infect wounds. Reporting in the March ...

  6. Chagas Vaccine Shows Promise in Mice

    Science.gov (United States)

    ... fullstory_152452.html Chagas Vaccine Shows Promise in Mice Parasitic disease is becoming more common in U.S. ... 8, 2015 (HealthDay News) -- An experimental vaccine provides mice with long-lasting protection against Chagas disease, which ...

  7. Ebola Drug Shows Promise in Monkey Trial

    Science.gov (United States)

    ... nlm.nih.gov/medlineplus/news/fullstory_150873.html Ebola Drug Shows Promise in Monkey Trial Experimental medicine ... HealthDay News) -- An investigational drug designed to stop Ebola in its tracks has shown early promise in ...

  8. Experimental Melanoma Vaccine Shows Early Promise

    Science.gov (United States)

    Experimental Melanoma Vaccine Shows Early Promise Still not clear if it will prevent recurrence or lengthen survival To use ... spur an immune response in people with advanced melanoma, a preliminary study finds. The experimental vaccine was ...

  9. MAP: Microblogging Assisted Profiling of TV Shows

    OpenAIRE

    Lin, Xiahong; Wang, Zhi; Sun, Lifeng

    2015-01-01

    Online microblogging services that have been increasingly used by people to share and exchange information, have emerged as a promising way to profiling multimedia contents, in a sense to provide users a socialized abstraction and understanding of these contents. In this paper, we propose a microblogging profiling framework, to provide a social demonstration of TV shows. Challenges for this study lie in two folds: First, TV shows are generally offline, i.e., most of them are...

  10. 2008 LHC Open Days Physics: the show

    CERN Multimedia

    2008-01-01

    A host of events and activities await visitors to the LHC Open Days on 5 and 6 April. A highlight will be the physics shows funded by the European Physical Society (EPS), which are set to surprise and challenge children and adults alike! School children use their experience of riding a bicycle to understand how planets move around the sun (Copyright : Circus Naturally) Participating in the Circus Naturally show could leave a strange taste in your mouth! (Copyright : Circus Naturally) The Rino Foundation’s experiments with liquid nitrogen can be pretty exciting! (Copyright: The Rino Foundation)What does a bicycle have in common with the solar system? Have you ever tried to weigh air or visualise sound? Ever heard of a vacuum bazooka? If you want to discover the answers to these questions and more then come to the Physics Shows taking place at the CERN O...

  11. Static and fatigue failure of quasi brittle materials at a V-notch using a Dugdale model

    OpenAIRE

    Murer, S.; Leguillon, D.

    2009-01-01

    Abstract The prediction of crack nucleation at stress concentration points in brittle and quasi-brittle materials may generally rely on either an Irwin-like criterion, involving a critical value of the generalized stress intensity factor of the singularity associated to the stress concentration, or on cohesive zone models. Leguillon's criterion enters the first category and combines an energy condition and a stress one. Thanks to matched asymptotics procedures, the associated numer...

  12. Show Them You Really Want the Job

    Science.gov (United States)

    Perlmutter, David D.

    2012-01-01

    Showing that one really "wants" the job entails more than just really wanting the job. An interview is part Broadway casting call, part intellectual dating game, part personality test, and part, well, job interview. When there are 300 applicants for a position, many of them will "fit" the required (and even the preferred) skills listed in the job…

  13. ShowOrHide 1.0

    Science.gov (United States)

    2012-08-24

    Many Mac users have hidden files located on their computers that they might not know about. ShowOrHide is a utility designed to locate invisible files and folders so that users will have more knowledge about such items. This program is compatible with computers running Mac OS X 10.5 or later.

  14. Development, management and economy of show caves.

    Directory of Open Access Journals (Sweden)

    Cigna Arrigo A.

    2000-01-01

    Full Text Available The problems concerning the development of show caves are here considered by taking into account different aspects of the problem. A procedure to carry out an Environmental Impact Assessment (EIA has been established in the last decade and it is now currently applied. Such an assessment starts with a pre-operational phase to obtain sufficient information on the undisturbed status of a cave to be developed into a show cave. Successively a programme for its development is established with the scope to optimise the intervention on the cave at the condition that its basic environmental parameters are not irreversibly modified. The last phase of the assessment is focussed to assure a feedback through a monitoring network in order to detect any unforeseen difference or anomaly between the project and the effective situation achieved after the cave development. Some data on some of the most important show caves in the world are reported and a tentative evaluation of the economy in connection with the show caves business is eventually made.

  15. Children's Art Show: An Educational Family Experience

    Science.gov (United States)

    Bakerlis, Julienne

    2007-01-01

    In a time of seemingly rampant budget cuts in the arts in school systems throughout the country, a children's art show reaps many rewards. It can strengthen family-school relationships and community ties and stimulate questions and comments about the benefits of art and its significance in the development of young children. In this photo essay of…

  16. Transplant Problems That May Show Up Later

    Science.gov (United States)

    ... more people are living longer and doctors are learning more about the long-term results of stem ... and high-dose chemo as part of the conditioning treatment Previous chemo or radiation treatment that was ...

  17. The Source of Lake Wobegon (slide show)

    OpenAIRE

    Richard P. PHELPS

    2007-01-01

    John J. Cannell's late 1980's "Lake Wobegon" reports suggested widespread deliberate educator manipulation of norm-referenced standardized test (NRT) administrations and results, resulting in artificial test score gains. The Cannell studies have been referenced in education research since, but as evidence that high stakes (and not cheating or lax security) cause test score inflation. This article examines that research and Cannell's data for evidence that high stakes cause test score inflatio...

  18. EXPERT SYSTEMS SHOW PROMISE FOR CUSTOMER INQUIRIES

    Science.gov (United States)

    This article describes results of an agreement between the North Penn Water Authority in Lansdale, Pa., and the US Environmental Protection Agency, Drinking Water Research Division, Cincinnati, Ohio, to study use of expert systems technology in a water utility. The threeyear stud...

  19. High temperature filter tests show exposure reduction

    International Nuclear Information System (INIS)

    The results of reduction of exposure dose at BWR type reactors of the first and second NPP units in Oxcarshamen by means of high temperature filters of new construction are presented. In new filters instead of wire cuttings changeable cartridges are used. Each filtering cartridge is fixed in a stable vessel with flanges. Two or more cartridges connected in parallel constitute a new high temperature filter. The first test results have shown that the total 60Co absorption efficiency constitutes approximately 70%, 58Co is considerably higher, for 54Mn and 65Zn it is equal approximately 40%. For several years of NPP operation the application of new filters reduces the dose rate by approximately 35%

  20. Rich Internet Publications: "Show What You Tell"

    OpenAIRE

    Breure, Leen; Utrecht University; Voorbij, Hans; Utrecht University; Hoogerwerf, Maarten; Royal Netherlands Academy of Arts and Sciences (KNAW)

    2011-01-01

    The journal article is still the basis of scholarly communication. This genre, however, largely adheres to the rules of the printed publication and does not meet the requirements of this age of digital Web publishing. Today we do not need to restrict ourselves any longer to communicating the results of the research process only. We can also allow readers to inspect the underlying data online, to publish their own comments and, using a variety of multimedia content, to be witness to i...

  1. ArtBots: The Robot Talent Show

    Science.gov (United States)

    Sponsored by the Columbia University Computer Music Center and the Digital Media Center of Columbia University's School of the Arts, ArtBots is "an international art exhibition for robotic art and art-making robots." The annual event invites artists from around the world to enter their robots based on the broad guidelines: "if you think it's a robot and you think it's art, we encourage you to submit." The Participants section includes a photo, description (including some interpretive analysis) and website link for each of the ArtBot 2004 participants. Some sample entries include a robot that draws, one that picks up balls and a "robotic sculpture built around a section of tree trunk." The website even offers a sample of the Theme Song from the show.

  2. Effective Marketing Strategies to Attract Business Visitors at Trade Shows

    Directory of Open Access Journals (Sweden)

    Mei-Chin Chu

    2013-11-01

    Full Text Available Trade shows have been the focus of recent research as constituting one of the most effective marketing strategies.Related issues have been discussed extensively in the literature. How to achieve better performance is central tothese discussions. Studies on the key factors that influence trade show performance have focused mainly onsubjective opinions from the perspective of the staff at exhibitions. In this study, we explored the key criteria fora business visitor in selecting suppliers at a trade show; that is, what kind of trade show strategies can promoteexhibitors’ performance? Trade show strategies from previous studies were first summarized. They wereclassified into three categories: before, at, and after the show. To address the problem of complexity anduncertainty, a fuzzy analytic hierarchy process (FAHP was used to explore the importance of the variousstrategies. The results showed that "follow-up after the exhibition" was the most important factor from theperspective of business visitors. “Active invitation before the exhibition” was considered to be the next mostimportant issue in attracting business visitors at a trade show. Among at-show strategies, the most important wasthat of staff knowledge of the product and trade details. The results of this study could contribute to enhancingtrade show performance.

  3. Geminids 2012 - a spectacular show from Oman

    Science.gov (United States)

    Weiland, Thomas; Bettonvil, Felix

    2014-02-01

    The Geminids are the most reliable prominent meteor shower currently visible. They can be observed from the whole northern hemisphere and even low southern latitudes as well. Nevertheless, as the weather is often unfavourable in Central Europe during December, a six-day-long visual observing campaign was carried out from Oman in 2012. There observing conditions were nearly perfect, especially in the Rub al-Khali desert in the western part of the country. As a consequence, we managed to record more than 1800 Geminids within almost 45 hours of effective observing time. An impression of the campaign together with a summary of the results is given.

  4. YELLOW HYPERGIANTS SHOW LONG SECONDARY PERIODS?

    Energy Technology Data Exchange (ETDEWEB)

    Stothers, Richard B. [NASA Goddard Institute for Space Studies, 2880 Broadway, New York, NY 10025 (United States)

    2012-06-01

    There is observational evidence that intermittent long secondary periods of {approx}1000 days are present in the well-observed yellow hypergiants {rho} Cas and HR 8752. The long secondary period is interpreted here as the turnover time of giant convection cells in the convective envelope, as has been already suggested in the case of red giants and supergiants of high luminosity. The observed secondary periods and surface radial velocities of {rho} Cas and HR 8752 agree with the theoretical predictions, within the expected errors. These results support a theoretical interpretation that now covers the entire initial mass range from 1 to 50 M{sub Sun} for luminous cool stars.

  5. The Source of Lake Wobegon (slide show

    Directory of Open Access Journals (Sweden)

    Richard P. Phelps

    2007-05-01

    Full Text Available John J. Cannell's late 1980's "Lake Wobegon" reports suggested widespread deliberate educator manipulation of norm-referenced standardized test (NRT administrations and results, resulting in artificial test score gains. The Cannell studies have been referenced in education research since, but as evidence that high stakes (and not cheating or lax security cause test score inflation. This article examines that research and Cannell's data for evidence that high stakes cause test score inflation. No such evidence is found. Indeed, the evidence indicates that, if anything, the absence of high stakes is associated with artificial test score gains. The variable most highly correlated with test score inflation is general performance on achievement tests, with traditionally low-performing states exhibiting more test score inflation on low-stakes norm-referenced tests than traditionally high-performing states, regardless of whether or not a state also maintains a high-stakes testing program. The unsupported high-stakes-cause-test-score-inflation hypothesis seems to derive from the surreptitious substitution of an antiquated definition of the term "high stakes" and a few studies afflicted with left-out-variable bias. The source of test-score inflation is lax security, regardless the stakes of a test.

  6. Nanorod heterostructures showing photoinduced charge separation.

    Science.gov (United States)

    Kumar, Sandeep; Jones, Marcus; Lo, Shun S; Scholes, Gregory D

    2007-09-01

    Size- and shape-dependent property modifications of semiconductor nanocrystals have been a subject of intense interest because of their potential for future engineering devices. The bandgap and related optical-property tuning of these materials are mainly governed by the nature of their band edges. In addition, fusing one type of nanocrystal over another enables further control of material properties that are dependent on the relative alignments of their energy levels. On a molecular scale, the synthesis of supramolecular compounds has inspired advances in theories for photoinduced charge transfer. Heterostructured nanocrystals potentially provide a nanoscale analog of such systems. A method for preparing heterostructured nanocrystals of complex morphologies showing photoinduced charge separation is presented. It is shown that the energy and lifetime of the charge-transfer photoluminescence band can be tuned by changing the relative alignment of band edges in CdSe/CdTe heterostructure nanorods. The long-lived charge transfer states in these type II semiconductors may make them attractive for photovoltaic applications. PMID:17705316

  7. BROOKHAVEN: ISABELLE magnets show their paces

    International Nuclear Information System (INIS)

    While funding for the ISABELLE 400 GeV proton-proton collider project is yet to be finalized, development continues of the superconducting magnets for this machine. Encouraging results have been achieved so far in the 'training' of four of the magnets operated in liquid helium at 4.5 K. All operate above the design field, corresponding to a proton beam energy of 400 GeV. Tests are under way on the magnets' resilience to quenches. Investigations of field quality were not among the objectives with these first magnets, but will be carried out with the short dipoles now under construction. The magnets seem well on the way to being able to meet the required conditions, and work continues apace

  8. Do Education Organizations Show Learning Organizations Charecterics?

    Directory of Open Access Journals (Sweden)

    Sedat Yumusak,

    Full Text Available Learning, an important element in terms of affecting the change of individual, organizational and social structures, will occur more effectively when the institutions in social structure turn into learning organizations. Senge (1993 concept of learning organization, constantly changing, evolving and renewing itself described as a dynamic structure. This concept has an important place in all institutions is also a separate meaning for educational institutions. In this context, schools training the human resources, appropriate for the aim of being information society, as individuals have taken continuous learning as their principles, teachers providing educational and supporting services and their perceptions of learning organization are of the great importance. In Bal?kesir, the study was conducted virtue of this importance has been serving the state and private institutions serving 848 elementary teachers, perceptions of the learning organization and organizational barriers that prevent it is to be determined through a comparative analysis. As a result of the survey, in the framework of the bases in literature, it has been found out that the state primary schools don’t have the features of learning organization, contrary to the private primary schools.

  9. Comportamento agressivo em shows musicais: analisando notícias de jornal impresso

    Directory of Open Access Journals (Sweden)

    Carlos Eduardo Pimentel

    2011-08-01

    Full Text Available This paper reports a content analysis of the newspaper articles dealing with aggressive behavior in music shows. This analysis permits an understanding of the characteristics of these situations, the aggressive behaviors in shows, and the way in which the print media treat the subject. Despite of the newspapers’ influence on public opinion formation, that is, the transmission of attitudes and behavior repertoires, this kind of analysis is rarely reported in Brazilian social psychological literature. Some 31 newspaper articles were content analyzed as to aggressive behavior during music shows. Results indicate that aggressive behaviors occur in shows of most varied musical styles. Results are discussed on the basis of social cognitive theory.

  10. Managing Trade Show Campaigns:Why Managerial Responsibilities Matter?

    OpenAIRE

    Tafesse, Wondwesen; Korneliussen, Tor

    2012-01-01

    This article examined the relationship between managerial responsibilities for important trade show tasks and the marketing performance of exhibiting firms. Drawing theoretical insights from the functionalist perspective of managerial roles and organizational role theory, this article proposed and validated theory based, multiple, task-managerial responsibility linkages using a large international b2b trade show as a context. The empirical results indicated that the marketing performance of e...

  11. Irradiation embrittlement of ASTM A533 steel: The UKAEA contribution to an IAEA comparative test programme

    International Nuclear Information System (INIS)

    Tensile, Charpy V notch impact and instrumented impact tests have been made on A533 Grade B Class 1 Steel as part of an IAEA co-ordinated testing programme. Tests were made to show the effect of irradiation at 290degC to a neutron dose of 1.75 x 1019n cm-2 (>1MeV). The results show an increase in strength and degree of embrittlement after irradiation which are lower than those determined in the ORNL facility and have demonstrated that it might be possible to use instrumented impact tests to give an estimate of dynamic fracture toughness data. (author)

  12. Do Tantalum and Titanium Cups Show Similar Results in Revision Hip Arthroplasty?

    OpenAIRE

    Jafari, S. Mehdi; Bender, Benjamin; Coyle, Catelyn; Parvizi, Javad; Sharkey, Peter F.; Hozack, William J.

    2009-01-01

    Porous surfaces are intended to enhance osteointegration of cementless implants. Tantalum has been introduced in an effort to enhance osseointegration potential of uncemented components. We therefore compared the clinical outcome of acetabular components with two different porous surfaces. We retrospectively reviewed 283 patients (295 hips) who underwent cementless revision hip arthroplasty with either an HA-coated titanium cup (207 patients, 214 hips) or porous tantalum cup (79 patients, 81 ...

  13. FES Training in Aging: interim results show statistically significant improvements in mobility and muscle fiber size

    OpenAIRE

    Helmut Kern; Stefan Loefler; Christian Hofer; Michael Vogelauer; Samantha Burggraf; Martina Grim-Stieger; Jan Cvecka; Dusan Hamar; Nejc Sarabon; Feliciano Protasi; Antonio Musarò; Marco Sandri; Katia Rossini; Ugo Carraro; Sandra Zampieri

    2012-01-01

    Aging is a multifactorial process that is characterized by decline in muscle mass and performance. Several factors, including reduced exercise, poor nutrition and modified hormonal metabolism, are responsible for changes in the rates of protein synthesis and degradation that drive skeletal muscle mass reduction with a consequent decline of force generation and mobility functional performances. Seniors with normal life style were enrolled: two groups in Vienna (n=32) and two groups in Bratisla...

  14. UC Davis study shows how DNA finds its match

    Science.gov (United States)

    It’s been more than 50 years since James Watson and Francis Crick showed that DNA is a double helix of two strands that complement each other. But how does a short piece of DNA find its match, out of the millions of "letters" in even a small genome? New work by researchers at the University of California, Davis, handling and observing single molecules of DNA, shows how it’s done. The results are published online Feb. 8 by the journal Nature.

  15. Glucosuria in Norwegian elkhounds and other breeds during dog shows.

    Science.gov (United States)

    Heiene, R; Bjørndal, H; Indrebø, A

    2010-04-10

    Clinically healthy Norwegian elkhounds were tested for glucosuria by urine dipstick analysis and the results were compared with a group of dogs of other breeds during 15 dog shows. Fifty-two of 187 Norwegian elkhounds (27.3 per cent) and 15 of 202 dogs of other breeds (7.4 per cent) were glucosuric during the dog shows; the difference was statistically significant. Two of the glucosuric elkhounds and one non-glucosuric elkhound developed signs of kidney disease during the year of the study. PMID:20382934

  16. Effect of copper content on the microstructure and mechanical properties of multipass MMA, low alloy steel weld metal deposits

    International Nuclear Information System (INIS)

    Effect of copper content in the range of 0.14-0.94 wt.% on the microstructure and mechanical properties of Cr-Ni-Cu low alloy steel weld metal deposits was investigated. All welds were prepared by manual metal arc welding technique in flat position. Microstructure of the welds was examined by optical and scanning electron microscopes. The results showed increase in acicular ferrite and microphases formed at the expense of primary ferrite and ferrite with second phase with steady refinement of microstructure. According to these microstructural changes, hardness, yield and ultimate tensile stresses increased while Charpy V-notch impact toughness and percent elongation reduced.

  17. The neonicotinoid imidachloprid shows high chronic toxicity to mayfly nymphs

    OpenAIRE

    Roessink, I.; Merga, L.B.; Zweers, A.J.; Brink, P.J., van den

    2013-01-01

    The present study evaluated the acute and chronic toxicity of imidacloprid to a range of freshwater arthropods. Mayfly and caddisfly species were most sensitive to short-term imidacloprid exposures (10 tests), whereas the mayflies showed by far the most sensitive response to long-term exposure of all seven arthropod species tested (28-d EC10 values of approximately 0.03?µg/L). The results indicated a high aquatic risk of chronic exposure of imidacloprid to mayflies.

  18. Modifiers of epigenetic reprogramming show paternal effects in the mouse

    OpenAIRE

    Chong, Suyinn; Vickaryous, Nicola; Ashe, Alyson; Zamudio, Natasha; Youngson, Neil; Hemley, Sarah; Stopka, Tomas; Skoultchi, Arthur; Matthews, Jacqui; Scott, Hamish S.; de Kretser, David; O’Bryan, Moira; Blewitt, Marnie; Whitelaw, Emma

    2007-01-01

    There is increasing evidence that epigenetic information can be inherited across generations in mammals, despite extensive reprogramming both in the gametes and in the early developing embryo. One corollary to this is that disrupting the establishment of epigenetic state in the gametes of a parent, as a result of heterozygosity for mutations in genes involved in reprogramming, could affect the phenotype of offspring that do not inherit the mutant allele. Here we show that such effects do occu...

  19. Mutants Showing Heterothallism from a Homothallic Strain of SACCHAROMYCES CEREVISIAE

    OpenAIRE

    Oshima, Takehiro; Takano, Isamu

    1980-01-01

    Mutants defective in mating-type conversion were isolated from ascospores of a perfect homothallism strain having the HO HMRa HML? genotype. Eighty mutants, including 11 temperature-dependent mutants showing a or ? mating potency, were isolated from 10,050 colonies derived from spores mutagenized with ethyl methanesulfonate. Of the 80 mutants, 48 were tested by crossing with an ho HMRa HML? heterothallic and an HO HMRa HML? homothallic strain as standards. The results allowed their divisi...

  20. Measuring political polarization: Twitter shows the two sides of Venezuela

    Science.gov (United States)

    Morales, A. J.; Borondo, J.; Losada, J. C.; Benito, R. M.

    2015-03-01

    We say that a population is perfectly polarized when divided in two groups of the same size and opposite opinions. In this paper, we propose a methodology to study and measure the emergence of polarization from social interactions. We begin by proposing a model to estimate opinions in which a minority of influential individuals propagate their opinions through a social network. The result of the model is an opinion probability density function. Next, we propose an index to quantify the extent to which the resulting distribution is polarized. Finally, we apply the proposed methodology to a Twitter conversation about the late Venezuelan president, Hugo Chávez, finding a good agreement between our results and offline data. Hence, we show that our methodology can detect different degrees of polarization, depending on the structure of the network.

  1. Measuring Political Polarization: Twitter shows the two sides of Venezuela

    CERN Document Server

    Morales, A J; Losada, J C; Benito, R M

    2015-01-01

    We say that a population is perfectly polarized when divided in two groups of the same size and opposite opinions. In this paper, we propose a methodology to study and measure the emergence of polarization from social interactions. We begin by proposing a model to estimate opinions in which a minority of influential individuals propagate their opinions through a social network. The result of the model is an opinion probability density function. Next, we propose an index to quantify the extent to which the resulting distribution is polarized. Finally, we apply the proposed methodology to a Twitter conversation about the late Venezuelan president, Hugo Ch\\'avez, finding a good agreement between our results and offline data. Hence, we show that our methodology can detect different degrees of polarization, depending on the structure of the network.

  2. Measuring political polarization: Twitter shows the two sides of Venezuela.

    Science.gov (United States)

    Morales, A J; Borondo, J; Losada, J C; Benito, R M

    2015-03-01

    We say that a population is perfectly polarized when divided in two groups of the same size and opposite opinions. In this paper, we propose a methodology to study and measure the emergence of polarization from social interactions. We begin by proposing a model to estimate opinions in which a minority of influential individuals propagate their opinions through a social network. The result of the model is an opinion probability density function. Next, we propose an index to quantify the extent to which the resulting distribution is polarized. Finally, we apply the proposed methodology to a Twitter conversation about the late Venezuelan president, Hugo Chávez, finding a good agreement between our results and offline data. Hence, we show that our methodology can detect different degrees of polarization, depending on the structure of the network. PMID:25833436

  3. Face and body recognition show similar improvement during childhood.

    Science.gov (United States)

    Bank, Samantha; Rhodes, Gillian; Read, Ainsley; Jeffery, Linda

    2015-09-01

    Adults are proficient in extracting identity cues from faces. This proficiency develops slowly during childhood, with performance not reaching adult levels until adolescence. Bodies are similar to faces in that they convey identity cues and rely on specialized perceptual mechanisms. However, it is currently unclear whether body recognition mirrors the slow development of face recognition during childhood. Recent evidence suggests that body recognition develops faster than face recognition. Here we measured body and face recognition in 6- and 10-year-old children and adults to determine whether these two skills show different amounts of improvement during childhood. We found no evidence that they do. Face and body recognition showed similar improvement with age, and children, like adults, were better at recognizing faces than bodies. These results suggest that the mechanisms of face and body memory mature at a similar rate or that improvement of more general cognitive and perceptual skills underlies improvement of both face and body recognition. PMID:25909913

  4. The use of computerized tomography in patients showing tardive dyskinesia

    International Nuclear Information System (INIS)

    29 patients showing moderate to markedly pronounced tardive dyskinesia (TD) and a further 29 control patients (C) under a similar long-term medication with neuroleptics that had been so chosen as to match the age and sex distributions of the former group were subjected to computered tomography, neurological examination and psychological testing. The results did not point to any correlations between the structural changes and duration of treatment and the clinical signs or symptoms of extrapyramidal disorder. This was taken as further evidence in support of the theory that the initial damage in tardive dyskinesia mainly is at the level of the basal ganglia. (orig./MG)

  5. Oil and gas shows numerous in Nama basin, southern Africa

    Energy Technology Data Exchange (ETDEWEB)

    Walter, M. [Rix and Walter Pty. Ltd., Bawley Point, New South Wales (Australia); Swart, R. [National Petroleum Corp. of Namibia Pty. Ltd., Windhoek (Namibia); Summons, R. [Australian Geological Survey Organisation, Canberra (Australia)

    1996-11-25

    No local sources of oil and gas are on production in southwestern Africa. The as yet undeveloped Kudu gas field off Namibia is the first major discovery, but there are numerous shows in the onshore Nama basin that suggest there could be significant accumulations of hydrocarbons present. The Nama basin occupies 350,000 sq km of southern Namibia, western Botswana, and northwestern South Africa and contains 10 km or more of Neoproterozoic and Cambrian sediment. National petroleum Corp. of Namibia recently embarked on an assessment of the prospectivity of the basin, and there the authors report some of the first results.

  6. Phytoceramide Shows Neuroprotection and Ameliorates Scopolamine-Induced Memory Impairment

    Directory of Open Access Journals (Sweden)

    Seikwan Oh

    2011-10-01

    Full Text Available The function and the role phytoceramide (PCER and phytosphingosine (PSO in the central nervous system has not been well studied. This study was aimed at investigating the possible roles of PCER and PSO in glutamate-induced neurotoxicity in cultured neuronal cells and memory function in mice. Phytoceramide showed neuro-protective activity in the glutamate-induced toxicity in cultured cortical neuronal cells. Neither phytosphingosine nor tetraacetylphytosphingosine (TAPS showed neuroproective effects in neuronal cells. PCER (50 mg/kg, p.o. recovered the scopolamine-induced reduction in step-through latency in the passive avoidance test; however, PSO did not modulate memory function on this task. The ameliorating effects of PCER on spatial memory were confirmed by the Morris water maze test. In conclusion, through behavioral and neurochemical experimental results, it was demonstrated that central administration of PCER produces amelioration of memory impairment. These results suggest that PCER plays an important role in neuroprotection and memory enhancement and PCER could be a potential new therapeutic agent for the treatment of neurodegenerative diseases such as Alzheimer’s disease.

  7. Children with autism spectrum disorder show reduced adaptation to number.

    Science.gov (United States)

    Turi, Marco; Burr, David C; Igliozzi, Roberta; Aagten-Murphy, David; Muratori, Filippo; Pellicano, Elizabeth

    2015-06-23

    Autism is known to be associated with major perceptual atypicalities. We have recently proposed a general model to account for these atypicalities in Bayesian terms, suggesting that autistic individuals underuse predictive information or priors. We tested this idea by measuring adaptation to numerosity stimuli in children diagnosed with autism spectrum disorder (ASD). After exposure to large numbers of items, stimuli with fewer items appear to be less numerous (and vice versa). We found that children with ASD adapted much less to numerosity than typically developing children, although their precision for numerosity discrimination was similar to that of the typical group. This result reinforces recent findings showing reduced adaptation to facial identity in ASD and goes on to show that reduced adaptation is not unique to faces (social stimuli with special significance in autism), but occurs more generally, for both parietal and temporal functions, probably reflecting inefficiencies in the adaptive interpretation of sensory signals. These results provide strong support for the Bayesian theories of autism. PMID:26056294

  8. Female migraineurs show lack of insular thinning with age.

    Science.gov (United States)

    Maleki, Nasim; Barmettler, Gabi; Moulton, Eric A; Scrivani, Steven; Veggeberg, Rosanna; Spierings, Egilius L H; Burstein, Rami; Becerra, Lino; Borsook, David

    2015-07-01

    Gray matter loss in cortical regions is a normal ageing process for the healthy brain. There have been few studies on the process of ageing of the brain in chronic neurological disorders. In this study, we evaluated changes in the cortical thickness by age in 92 female subjects (46 patients with migraine and 46 healthy controls) using high-field magnetic resonance imaging. The results indicate that in contrast to healthy subjects, migraineurs show a lack of thinning in the insula by age. The functional significance of the lack of thinning is unknown, but it may contribute to the overall cortical hyperexcitability of the migraine brain because the region is tightly involved in a number of major brain networks involved in interoception, salience, nociception, and autonomic function, including the default mode network. PMID:25775358

  9. Model experiments showing simultaneous development of folds and transcurrent faults

    Science.gov (United States)

    Dubey, Ashok Kumar

    1980-05-01

    Simultaneous development of noncylindrical folds and transcurrent fractures has been studied using model techniques. A plasticine model was compressed in one direction and an initial formation of folds was followed by the initiation of conjugate sets of transcurrent fractures. It was recorded that with progressive deformation the length of each fracture and the displacement along it increase steadily and the rate of displacement varies at different stages of deformation. Individual fold geometries vary along their hinge lines and these geometrical variations appear to be due to interference of folds with the transcurrent fractures. These interference effects also change the amount of rotation of fractures. Fold structures are different on either side of the fault plane. A natural example from the Bude area, England, shows similar geometrical features. The method of determining fault displacement by comparing the positions of fold hinge lines on either side of a fault is discussed in the light of the above results.

  10. Atlantic salmon show capability for cardiac acclimation to warm temperatures.

    Science.gov (United States)

    Anttila, Katja; Couturier, Christine S; Overli, Oyvind; Johnsen, Arild; Marthinsen, Gunnhild; Nilsson, Göran E; Farrell, Anthony P

    2014-01-01

    Increases in environmental temperature predicted to result from global warming have direct effects on performance of ectotherms. Moreover, cardiac function has been observed to limit the tolerance to high temperatures. Here we show that two wild populations of Atlantic salmon originating from northern and southern extremes of its European distribution have strikingly similar cardiac responses to acute warming when acclimated to common temperatures, despite different local environments. Although cardiac collapse starts at 21-23?°C with a maximum heart rate of ~150 beats per min (bpm) for 12?°C-acclimated fish, acclimation to 20?°C considerably raises this temperature (27.5?°C) and maximum heart rate (~200?bpm). Only minor population differences exist and these are consistent with the warmer habitat of the southern population. We demonstrate that the considerable cardiac plasticity discovered for Atlantic salmon is largely independent of natural habitat, and we propose that observed cardiac plasticity may aid salmon to cope with global warming. PMID:24957572

  11. Bex1 knock out mice show altered skeletal muscle regeneration

    International Nuclear Information System (INIS)

    Bex1 and Calmodulin (CaM) are upregulated during skeletal muscle regeneration. We confirm this finding and demonstrate the novel finding that they interact in a calcium-dependent manner. To study the role of Bex1 and its interaction with CaM in skeletal muscle regeneration, we generated Bex1 knock out (Bex1-KO) mice. These mice appeared to develop normally and are fertile, but displayed a functional deficit in exercise performance compared to wild type (WT) mice. After intramuscular injection of cardiotoxin, which causes extensive and reproducible myotrauma followed by recovery, regenerating muscles of Bex1-KO mice exhibited elevated and prolonged cell proliferation, as well as delayed cell differentiation, compared to WT mice. Thus, our results provide the first evidence that Bex1-KO mice show altered muscle regeneration, and allow us to propose that the interaction of Bex1 with Ca2+/CaM may be involved in skeletal muscle regeneration

  12. Silver nanoparticles synthesised using plant extracts show strong antibacterial activity.

    Science.gov (United States)

    Kumari, Avnesh; Guliani, Anika; Singla, Rubbel; Yadav, Ramdhan; Yadav, Sudesh Kumar

    2015-06-01

    In this study, three plants Populus alba, Hibiscus arboreus and Lantana camara were explored for the synthesis of silver nanoparticles (SNPs). The effect of reaction temperature and leaf extract (LE) concentration of P. alba, H. arboreus and L. camara was evaluated on the synthesis and size of SNPs. The SNPs were characterised by ultra-violet-visible spectroscopy, scanning electron microscopy and atomic force microscopy. The synthesis rate of SNPs was highest with LE of L. camara followed by H. arboreus and P. alba under similar conditions. L. camara LE showed maximum potential of smaller size SNPs synthesis, whereas bigger particles were formed by H. arboreous LE. The size and shape of L. camara LE synthesised SNPs were analysed by transmission electron microscopy (TEM) and energy dispersive X-ray spectroscopy (EDX). TEM analysis revealed the formation of SNPs of average size 17 ± 9.5 nm with 5% LE of L. camara. The SNPs synthesised by LE of L. camara showed strong antibacterial activity against Escherichia coli. The results document that desired size SNPs can be synthesised using these plant LEs at a particular temperature for applications in the biomedical field. PMID:26023158

  13. PROTOTIPE VIDEO EDITOR DENGAN MENGGUNAKAN DIRECT X DAN DIRECT SHOW

    Directory of Open Access Journals (Sweden)

    Djoni Haryadi Setiabudi

    2004-01-01

    Full Text Available Technology development had given people the chance to capture their memorable moments in video format. A high quality digital video is a result of a good editing process. Which in turn, arise the new need of an editor application. In accordance to the problem, here the process of making a simple application for video editing needs. The application development use the programming techniques often applied in multimedia applications, especially video. First part of the application will begin with the video file compression and decompression, then we'll step into the editing part of the digital video file. Furthermore, the application also equipped with the facilities needed for the editing processes. The application made with Microsoft Visual C++ with DirectX technology, particularly DirectShow. The application provides basic facilities that will help the editing process of a digital video file. The application will produce an AVI format file after the editing process is finished. Through the testing process of this application shows the ability of this application to do the 'cut' and 'insert' of video files in AVI, MPEG, MPG and DAT formats. The 'cut' and 'insert' process only can be done in static order. Further, the aplication also provide the effects facility for transition process in each clip. Lastly, the process of saving the new edited video file in AVI format from the application. Abstract in Bahasa Indonesia : Perkembangan teknologi memberi kesempatan masyarakat untuk mengabadikan saat - saat yang penting menggunakan video. Pembentukan video digital yang baik membutuhkan proses editing yang baik pula. Untuk melakukan proses editing video digital dibutuhkan program editor. Berdasarkan permasalahan diatas maka pada penelitian ini dibuat prototipe editor sederhana untuk video digital. Pembuatan aplikasi memakai teknik pemrograman di bidang multimedia, khususnya video. Perencanaan dalam pembuatan aplikasi tersebut dimulai dengan pembentukan kompresi dan dekompresi file video, kemudian dilanjutkan dengan proses editing terhadap file video digital. Selain itu program juga dilengkapi dengan fasilitas untuk mendukung proses editing. Aplikasi tersebut dibuat dengan Microsoft Visual C++ dengan menggunakan teknologi DirectX, khususnya DirectShow. Aplikasi tersebut meyediakan fasilitas - fasilitas dasar yang membantu proses editing pada video digital. Dengan aplikasi tersebut dihasilkan file video baru dalam format AVI yang terbentuk dari proses editing yang dilakukan. Hasil pengujian menunjukkan kemampuan aplikasi melakukan proses pemotongan dan penyisipan file video dalam format AVI, MPEG, MPG dan DAT. Proses pemotongan dan penyisipan dilakukan dengan urutan yang statis. Selain itu aplikasi juga menyediakan efek antara masing - masing clip. Dan yang terakhir melakukan proses penyimpanan satu file dalam format AVI yang terbentuk dari proses editing dalam aplikasi. Kata kunci: Multimedia, Video Editor, Direct-X, Direct-Show, AVI, MPG.

  14. Slippery liquid-infused porous surfaces showing marine antibiofouling properties.

    Science.gov (United States)

    Xiao, Linlin; Li, Junsheng; Mieszkin, Sophie; Di Fino, Alessio; Clare, Anthony S; Callow, Maureen E; Callow, James A; Grunze, Michael; Rosenhahn, Axel; Levkin, Pavel A

    2013-10-23

    Marine biofouling is a longstanding problem because of the constant challenges placed by various fouling species and increasingly restricted environmental regulations for antifouling coatings. Novel nonbiocidal strategies to control biofouling will necessitate a multifunctional approach to coating design. Here we show that slippery liquid-infused porous surfaces (SLIPSs) provide another possible strategy to obtaining promising antifouling coatings. Microporous butyl methacrylate-ethylene dimethacrylate (BMA-EDMA) surfaces are prepared via UV-initiated free-radical polymerization. Subsequent infusion of fluorocarbon lubricants (Krytox103, Krytox100, and Fluorinert FC-70) into the porous microtexture results in liquid-repellent slippery surfaces. To study the interaction with marine fouling organisms, settlement of zoospores of the alga Ulva linza and cypris larvae of the barnacle Balanus amphitrite is tested in laboratory assays. BMA-EDMA surfaces infused with Krytox103 and Krytox100 exhibit remarkable inhibition of settlement (attachment) of both spores and cyprids to a level comparable to that of a poly(ethylene glycol) (PEG)-terminated self-assembled monolayer. In addition, the adhesion strength of sporelings (young plants) of U. linza is reduced for BMA-EDMA surfaces infused with Krytox103 and Krytox100 compared to pristine (noninfused) BMA-EDMA and BMA-EDMA infused with Fluorinert FC-70. Immersion tests suggest a correlation between the stability of slippery coatings in artificial seawater and fouling resistance efficacy. The results indicate great potential for the application of this concept in fouling-resistant marine coatings. PMID:24067279

  15. Management in a neotropical show cave: planning for invertebrates conservation

    Directory of Open Access Journals (Sweden)

    Thais Giovannini Pellegrini

    2012-07-01

    Full Text Available Lapa Nova is a dolomitic cave about 4.5 km long located in northwestern Minas Gerais state, Brazil. The cave experiences intense tourism, concentrated over a single period of the year, during the Feast of Our Lady of Lapa. In order to evaluate the impacts felt by the invertebrate community from this tourism, a new methodology was proposed. Four types of areas (intense visitation area, outlying visitation areas, moderate visitation areas and no-visitation areas were sampled for invertebrates. There was one sampling prior and another on the last day of the 128th feast, to evaluate the effects of visitation on cave-dwelling invertebrates. Results show that invertebrate populations residing in more intensely visited areas of the cave undergo changes in distribution following the event. As a consequence of tourism, invertebrates shift to outlying locations from the visited area, which serve as refuges to the communities. Apparently, the fact that there are places inside Lapa Nova inaccessible to tourists reduces the impact suffered by the invertebrate community, as those sites serve as refuges for cave-dwelling organisms during the pilgrimage. A proper management plan was devised for the tourism/religious use of the cave. It consists basically of delimiting marked pathways for tourists, allowing invertebrates to seek shelter at locations outside visited areas and keeping no-visitation areas off-limits to tourism based on the results of the visitation effects on cave-dwelling invertebrates.

  16. A case of cerebral infarction showing interesting SPECT images

    International Nuclear Information System (INIS)

    A case of cerebral infarction showing interesting SPECT images was reported. One month after stroke, 81mKr and 99mTc-HMPAO-SPECT were showed post ischemic high flow area as hot lesion, but 123I-IMP-SPECT was showed as cold lesion in early scan. Two months after stroke, all SPECT images showed infarction as cold area. (author)

  17. Caveolin-1 null (-/-) mice show dramatic reductions in life span.

    Science.gov (United States)

    Park, David S; Cohen, Alex W; Frank, Philippe G; Razani, Babak; Lee, Hyangkyu; Williams, Terence M; Chandra, Madhulika; Shirani, Jamshid; De Souza, Andrea P; Tang, Baiyu; Jelicks, Linda A; Factor, Stephen M; Weiss, Louis M; Tanowitz, Herbert B; Lisanti, Michael P

    2003-12-30

    Caveolae are 50-100 nm flask-shaped invaginations of the plasma membrane found in most cell types. Caveolin-1 is the principal protein component of caveolae membranes in nonmuscle cells. The recent development of Cav-1-deficient mice has allowed investigators to study the in vivo functional role of caveolae in the context of a whole animal model, as these mice lack morphologically detectable caveolae membrane domains. Surprisingly, Cav-1 null mice are both viable and fertile. However, it remains unknown whether loss of caveolin-1 significantly affects the overall life span of these animals. To quantitatively determine whether loss of Cav-1 gene expression confers any survival disadvantages with increasing age, we generated a large cohort of mice (n = 180), consisting of Cav-1 wild-type (+/+) (n = 53), Cav-1 heterozygous (+/-) (n = 70), and Cav-1 knockout (-/-) (n = 57) animals, and monitored their long-term survival over a 2 year period. Here, we show that Cav-1 null (-/-) mice exhibit an approximately 50% reduction in life span, with major declines in viability occurring between 27 and 65 weeks of age. However, Cav-1 heterozygous (+/-) mice did not show any changes in long-term survival, indicating that loss of both Cav-1 alleles is required to mediate a reduction in life span. Mechanistically, these dramatic reductions in life span appear to be secondary to a combination of pulmonary fibrosis, pulmonary hypertension, and cardiac hypertrophy in Cav-1 null mice. Taken together, our results provide the first demonstration that loss of Cav-1 gene expression and caveolae organelles dramatically affects the long-term survival of an organism. In addition, aged Cav-1 null mice may provide a new animal model to study the pathogenesis and treatment of progressive hypertrophic cardiomyopathy and sudden cardiac death syndrome. PMID:14690422

  18. Material properties characterization of low carbon steel using TBW and PWHT techniques in smooth-contoured and U-shaped geometries

    International Nuclear Information System (INIS)

    This paper investigates the effects of the temper bead welding (TBW) technique and post weld heat treatment (PWHT) on mechanical properties of multi-layer welding on low carbon steel specimens using Charpy V-notch impact testing and tensile testing. Several samples of two different weld geometries, viz. (i) smooth-contoured, and (ii) U-shaped were made with multiple bead layers using both TBW and PWHT techniques. Impact testing showed that at room temperature and below, TBW gave an impact toughness in the Heat Affected Zone (HAZ) better than both PWHT and the parent material. At temperatures higher than the room temperature but below 60 °C, PWHT gave better impact toughness in the HAZ. Above 60 °C, both TBW and PWHT showed impact toughness lower than that of the parent material. In tensile testing, both TBW and PWHT weld metal specimens produced acceptable results; however, TBW gave yield and tensile strengths closer to that of the actual material than PWHT. -- Highlights: • Effects of post weld heat treatment (PWHT) and temper bead welding (TBW) on properties are tested. • Charpy V-notch impact and tensile testing was performed on multi-layer welding of low carbon steel. • At room temperature and below, TBW gave better impact toughness than both PWHT and parent material. • Above room temperature but below 60 °C, PWHT gave better impact toughness than TBW. • Above 60 °C, both TBW and PWHT showed impact toughness lower than that of parent material

  19. Optimizing the Natural Frequencies of Beams via Notch Stamping

    Directory of Open Access Journals (Sweden)

    Nabeel T. Alshabatat

    2012-07-01

    Full Text Available Natural frequency optimization is important to avoid the coincidence of excitation frequency and natural frequency which causes resonance phenomenon. In this study, the natural frequencies of a beam, with different boundary conditions, are enhanced by stamping V-notches on its surface. These notches alter the local stiffness in the beam while keeping the mass the same. This method is cost-effective in comparison with other Structural Dynamics Modification methods (SDM because it is a one-step manufacturing method and because it enhances the dynamic behavior of beam structures without additional weight or additional joints. The natural frequencies of notched beam are calculated by finite element method. In particular, ANSYS package is used in building the notched beam models for modal analysis. The effect of notch location and size on the beam fundamental frequency is investigated. The simulation results indicated that creating notches on free-free beam decreases its fundamental frequency, while creating notches on clamped beam may increase its fundamental frequency. The optimal designs of notched beams are presented. The proposed method couples a finite element method for the modal analysis with an optimization technique based on Genetic Algorithm (GA. Three examples are presented to show the optimal design of free-free and clamped notched beams. The optimization results show that V-notch stamping technique is an effective technique to optimize the natural frequencies.

  20. 5 CFR 2422.10 - Validity of showing of interest.

    Science.gov (United States)

    2010-01-01

    ...filed. Party challenges to the validity of a showing of interest must...hearing is held, challenges to the validity of a showing of interest must...pursuant to § 2422.30. (d) Contents of validity challenges. Challenges to...

  1. New Ebola Vaccine Shows Promise in Human Trials

    Science.gov (United States)

    ... nih.gov/medlineplus/news/fullstory_151665.html New Ebola Vaccine Shows Promise in Human Trials It appeared ... WEDNESDAY, March 25, 2015 (HealthDay News) -- An experimental Ebola vaccine shows promise in an early clinical trial, ...

  2. Giant pandas failed to show mirror self-recognition.

    Science.gov (United States)

    Ma, Xiaozan; Jin, Yuan; Luo, Bo; Zhang, Guiquan; Wei, Rongping; Liu, Dingzhen

    2015-05-01

    Mirror self-recognition (MSR), i.e., the ability to recognize oneself in a mirror, is considered a potential index of self-recognition and the foundation of individual development. A wealth of literature on MSR is available for social animals, such as chimpanzees, Asian elephants and dolphins, yet little is known about MSR in solitary mammalian species. We aimed to evaluate whether the giant panda can recognize itself in the mirror, and whether this capacity varies with age. Thirty-four captive giant pandas (F:M = 18:16; juveniles, sub-adults and adults) were subjected to four mirror tests: covered mirror tests, open mirror tests, water mark control tests, and mark tests. The results showed that, though adult, sub-adult and juvenile pandas exposed to mirrors spent similar amounts of time in social mirror-directed behaviors (?(2) = 0.719, P = 0.698), none of them used the mirror to touch the mark on their head, a self-directed behavior suggesting MSR. Individuals of all age groups initially displayed attacking, threatening, foot scraping and backwards walking behaviors when exposed to their self-images in the mirror. Our data indicate that, regardless of age, the giant pandas did not recognize their self-image in the mirror, but instead considered the image to be a conspecific. Our results add to the available information on mirror self-recognition in large mammals, provide new information on a solitary species, and will be useful for enclosure design and captive animal management. PMID:25609263

  3. Human-directed social behaviour in dogs shows significant heritability.

    Science.gov (United States)

    Persson, M E; Roth, L S V; Johnsson, M; Wright, D; Jensen, P

    2015-04-01

    Through domestication and co-evolution with humans, dogs have developed abilities to attract human attention, e.g. in a manner of seeking assistance when faced with a problem solving task. The aims of this study were to investigate within breed variation in human-directed contact seeking in dogs and to estimate its genetic basis. To do this, 498 research beagles, bred and kept under standardized conditions, were tested in an unsolvable problem task. Contact seeking behaviours recorded included both eye contact and physical interactions. Behavioural data was summarized through a principal component analysis, resulting in four components: test interactions, social interactions, eye contact and physical contact. Females scored significantly higher on social interactions and physical contact and age had an effect on eye contact scores. Narrow sense heritabilities (h(2) ) of the two largest components were estimated at 0.32 and 0.23 but were not significant for the last two components. These results show that within the studied dog population, behavioural variation in human-directed social behaviours was sex dependent and that the utilization of eye contact seeking increased with age and experience. Hence, heritability estimates indicate a significant genetic contribution to the variation found in human-directed social interactions, suggesting that social skills in dogs have a genetic basis, but can also be shaped and enhanced through individual experiences. This research gives the opportunity to further investigate the genetics behind dogs' social skills, which could also play a significant part into research on human social disorders such as autism. PMID:25703740

  4. Insertion Sequences show diverse recent activities in Cyanobacteria and Archaea

    Directory of Open Access Journals (Sweden)

    Xu Ying

    2008-01-01

    Full Text Available Abstract Background Mobile genetic elements (MGEs play an essential role in genome rearrangement and evolution, and are widely used as an important genetic tool. Results In this article, we present genetic maps of recently active Insertion Sequence (IS elements, the simplest form of MGEs, for all sequenced cyanobacteria and archaea, predicted based on the previously identified ~1,500 IS elements. Our predicted IS maps are consistent with the NCBI annotations of the IS elements. By linking the predicted IS elements to various characteristics of the organisms under study and the organism's living conditions, we found that (a the activities of IS elements heavily depend on the environments where the host organisms live; (b the number of recently active IS elements in a genome tends to increase with the genome size; (c the flanking regions of the recently active IS elements are significantly enriched with genes encoding DNA binding factors, transporters and enzymes; and (d IS movements show no tendency to disrupt operonic structures. Conclusion This is the first genome-scale maps of IS elements with detailed structural information on the sequence level. These genetic maps of recently active IS elements and the several interesting observations would help to improve our understanding of how IS elements proliferate and how they are involved in the evolution of the host genomes.

  5. Ca (II-EDTA shows antimicrobial activity against periodontopathic bacteria

    Directory of Open Access Journals (Sweden)

    Masao Yoshinari

    2012-01-01

    Full Text Available Ethylenediamine-N,N,N’,N’-tetraacetic acid calcium (II disodium salt (Ca (II-EDTA was investigated for its antibacterial activity against the periodontal pathogens Aggregatibacter actinomycetemcomitans, Prevotella intermedia and Porphyromonas gingivalis. We determined the minimum inhibitory concentrations (MIC of Ca (II-EDTA and its bactericidal activity. Ethylenediamine-N,N,N’,N’-tetraacetic acid calcium (II disodium salt inhibited the growth of all the periodontopathic bacteria tested in broth. An MIC of 60 mM was the most effective against P. gingivalis. An adenosine triphosphate bioluminescence assay revealed that Ca (II-EDTA showed bactericidal activity against the bacteria tested in a time-dependent manner. To determine its safety in mammalian cells, we investigated the viability of murine L929 cells subjected to Ca (II-EDTA treatment. At 75 mM, 93% ± 0.13% of the cells survived. These results indicate that Ca (II-EDTA is a candidate chelating agent for prevention of infection by periodontopathic bacteria.

  6. A lipase of Aeromonas hydrophila showing nonhemolytic phospholipase C activity.

    Science.gov (United States)

    Ingham, A B; Pemberton, J M

    1995-07-01

    Extracellular lipase activity detected on tributyrin agar has been identified in a cosmid clone, JM3084, constructed from the chromosome of Aeromonas hydrophila and vector pHC79. This lipase, named apl-1, also exhibits nonhemolytic phospholipase C activity on lecithin and p-nitrophenylphosphorylcholine. Subcloning of the cosmid JMP3084 with partial Sau3a1 digestion localized the lipase gene to a 3.4-kb DNA fragment. Southern blot analysis shows the gene apl-1 to exist in single copy on the A. hydrophila chromosome. Expression of apl-1 in the pT7 system identified a single protein of molecular weight 70 kDa. Nucleotide sequencing of apl-1 has identified an open reading frame of 2055 bases predicting a protein of 73 kDa. The presence of an amino terminal signal sequence of 18 amino acids accounts for this molecular weight disparity. Further analysis of the lipase amino acid sequence revealed the presence of a classical serine active lipase site (Gly-X-Ser-X-Gly) located between residues 561 and 570. The A. hydrophila chromosomal copy of apl-1 has been inactivated by use of the mutagenesis vector pJP5603, resulting in the complete removal of phospholipase C activity and lowered levels of lipase activity detected on tributyrin agar. PMID:7767226

  7. 47 CFR 73.33 - Antenna systems; showing required.

    Science.gov (United States)

    2010-10-01

    ...2010-10-01 2010-10-01 false Antenna systems; showing required. 73.33... AM Broadcast Stations § 73.33 Antenna systems; showing required. (a...application for authority to install a broadcast antenna shall specify a definite site and...

  8. The Presentation of Science in Everyday Life: The Science Show

    Science.gov (United States)

    Watermeyer, Richard

    2013-01-01

    This paper constitutes a case-study of the "science show" model of public engagement employed by a company of science communicators focused on the popularization of science, technology, engineering and mathematics (STEM) subject disciplines with learner constituencies. It examines the potential of the science show to foster the interest…

  9. TV shows on Light Pollution Education for the Public

    Science.gov (United States)

    Grigore, Valentin

    2015-03-01

    TV shows have the biggest impact for the public, so we can use them to inform and educate the public about light pollution and the importance of the dark sky for humanity and for the contemporary society. Some examples used in the TV show Us and the Sky at Columna TV, Romania, are presented.

  10. Landsat 7 Images Show Scale of Tsunami Damage

    Science.gov (United States)

    NASA

    This NASA page shows before and after pictures taken by Landsat 7's Enhanced Thematic Mapper Plus (ETM+) instrument of a part of the coast of Sumatra, Indonesia. The images show that the scale of the tsunami's impact can be seen from space.

  11. Computer Slide Shows: A Trap for Bad Teaching

    Science.gov (United States)

    Klemm, W. R.

    2007-01-01

    Slide shows presented with software such as PowerPoint or WordPerfect Presentations can trap instructors into bad teaching practices. Research on memory suggests that slide-show instruction can actually be less effective than traditional lecturing when the teacher uses a blackboard or overhead projector. The author proposes a model of classroom…

  12. ShowFlow: A practical interface for groundwater modeling

    Energy Technology Data Exchange (ETDEWEB)

    Tauxe, J.D.

    1990-12-01

    ShowFlow was created to provide a user-friendly, intuitive environment for researchers and students who use computer modeling software. What traditionally has been a workplace available only to those familiar with command-line based computer systems is now within reach of almost anyone interested in the subject of modeling. In the case of this edition of ShowFlow, the user can easily experiment with simulations using the steady state gaussian plume groundwater pollutant transport model SSGPLUME, though ShowFlow can be rewritten to provide a similar interface for any computer model. Included in this thesis is all the source code for both the ShowFlow application for Microsoft{reg sign} Windows{trademark} and the SSGPLUME model, a User's Guide, and a Developer's Guide for converting ShowFlow to run other model programs. 18 refs., 13 figs.

  13. 26 CFR 1.9000-3 - Requirement of statement showing increase in tax liability.

    Science.gov (United States)

    2010-04-01

    ...Requirement of statement showing increase in tax liability. 1.9000-3 Section 1.9000-3...Requirement of statement showing increase in tax liability. (a) Returns filed before June 15...Form 2175 showing the increase in tax liability resulting from the repeal of...

  14. QLab 3 show control projects for live performances & installations

    CERN Document Server

    Hopgood, Jeromy

    2013-01-01

    Used from Broadway to Britain's West End, QLab software is the tool of choice for many of the world's most prominent sound, projection, and integrated media designers. QLab 3 Show Control: Projects for Live Performances & Installations is a project-based book on QLab software covering sound, video, and show control. With information on both sound and video system basics and the more advanced functions of QLab such as MIDI show control, new OSC capabilities, networking, video effects, and microphone integration, each chapter's specific projects will allow you to learn the software's capabilitie

  15. Analysis and tests of TF magnet insulation samples for the JET upgrade to 4 tesla

    CERN Document Server

    Miele, P; Bettinali, L; Kaye, A; Last, J; Papastergiou, S; Riccardo, V; Visca, E

    2000-01-01

    The JET Toroidal Field (TF) coils were originally designed for operation at 3.4 tesla. In order to upgrade the field to 4 tesla and thus improve the performance of the JET machine, new mechanical tests and analysis were carried out on the insulation of TF coil samples. They are aimed at investigating the mechanical properties and the status of the insulation in order to set allowable stresses and force limits. In particular since the shear stress in the insulation is strongly affected by the shear modulus of elasticity G, it is important to measure this parameter. A method for the measurement of G in glass-resin fibres, the V-notched beam method (Iosipescu method) , was applied. The particular shape of the rectangular Iosipescu V- notched sample and the particular modality of force application produce pure shear stress for a reliable measurement of the G value and of the shear strength of the insulation. The effect of temperature on these mechanical properties was also investigated. Results show higher averag...

  16. Survey Shows Britons Have Trouble Identifying Art Masterpieces

    Science.gov (United States)

    Grinnell, Max

    While Americans seem lacking in geographical knowledge at times (such as the fact that some high school graduates do not think that New Mexico is part of the United States), a recent survey by the Encyclopedia Britannica indicates that Britons are unfamiliar with the masterpieces of art. The survey asked 500 adults aged 18 and over to identify the artists responsible for well-known paintings, and in the process, elicited some rather unusual responses. For example, one in 10 of those surveyed stated that Vincent van Gogh painted the Mona Lisa, and only 49 percent overall were able to correctly state that Leonardo da Vinci was in fact the creator of that work. Stranger still was the statistic that 7 per cent of those surveyed identified the creator of Water Lilies (painted many different times by Claude Monet) was in fact Rolf Harris, an Australian entertainer who plays the wobble board, and who recently recreated the famous Monet painting on a television show in Britain.The first link is to an online news article from the Guardian about the results of this intriguing poll on art literacy around Britain. The second link will take visitors to a news story from the Sydney Morning Herald that talks about the survey, along with a section about perceptions of how Australians view art. The third link leads to an online exhibit of Monet's works (including some renditions of Water Lilies), provided by the Museum of Fine Art in Boston. The fourth link leads to a nice site dedicated to Edvard Munch (another misidentified painter in the recent survey), which includes a fine online gallery of his works, some background material, and links to other online resources. The fifth link leads to a site provided by the Museum of Science in Boston on Leonardo Da Vinci that features some virtual tours of the exhibit, learning activities for young people, and suggestions for incorporating da Vinci into the classroom. The final link leads to the Web site of the multitalented Rolf Harris (also known as The Wizard of Aussi), who is a musician, painter, and live performer.

  17. Liquid Medical Marijuana Shows Promise Against Severe Epilepsy

    Science.gov (United States)

    ... extract," he said in an AAN news release. "These results are of great interest, especially for the children ... System in Manhasset, N.Y. Stevens believes that "these results stand as a stepping stone toward further studies ...

  18. Latest data shows long-term security of uranium supply

    International Nuclear Information System (INIS)

    Full text: According to Uranium 2009: Resources, Production and Demand just published by the OECD Nuclear En ergy Agency (NEA) and the International Atomic Energy Agency (IAEA), uranium resources, production and demand are all on the rise. Exploration efforts have increased recently in line with the expected expansion of nuclear energy in the coming years. Total identified resources have grown but so too have costs of production. Worldwide exploration and mine development expenditures have more than doubled since the publication of the previous edition, Uranium 2007: Resources, Production and Demand. These expenditures have increased despite declining uranium market prices since mid- 2007. The uranium resources presented in this edition, reflecting the situation as of 1 January 2009, show that total identified resources amounted to 6 306 300 tU, an increase of about 15% compared to 2007, including those reported in the high-cost category (< USD 260/kgU or < USD 100/lbU O), reintroduced for the first time since the 1980s. This high-cost 3 8 category was used in the 2009 edition in response to the generally increased market prices for uranium in recent years, despite the decline since mid-2007, expectations of increasing demand as new nuclear power plants are being planned and built, and increased mining costs. Although total identified resources have increased overall, there has been a significant reduction in lower-cost resources owing to increased mining costs. At 2008 rates of consumption, total identified resources are sufficient for over 100 years of supply. The recognition by an increasing number of governments that nuclear power can produce competitively priced, baseload electricity that is essentially free of greenhouse gas emissions, coupled with the role that nuclear can play in enhancing security of energy supply, increases the prospects for growth in nuclear generating capacity, although the magnitude of that growth remains to be determined. According to capacity projections developed in this edition, by the year 2035, world nuclear capacity is projected to grow to between 500 and 785 GWe net. Accordingly, world reactor- related uranium requirements are also projected to rise. As observed in the past, increased investment in exploration has resulted in important discoveries and the identification of new resources. It is foreseen that, if market conditions improve further, additional exploration will be stimulated leading to the identification of additional resources of economic interest. Even in the high-growth scenario to 2035, less than half of the identified resources described in this edition would be consumed. The challenge remains to develop mines in a timely and environmentally sustainable fashion as uranium demand increases. A strong market will be required for these resources to be developed within the time frame required to meet future uranium demand. In addition, current projections of uranium mine production capacities could satisfy projected high-case world uranium requirements until the late 2020s. However, given the challenges and length of time associated with increasing production at existing mines and opening new mines, it is unlikely that all production increases will proceed as planned. As a result, secondary sources of previously mined uranium will continue to be required, complemented to the extent possible by uranium savings achieved by specifying lower tails assays at enrichment facilities and technical developments in fuel cycle technology. While the status of supply and demand is considered from today's technologies perspective, it should be recognised that the deployment of advanced reactor and fuel cycle technologies can positively affect the long-term availability of uranium and could conceivably extend it to thousands of years. These are some of the findings from Uranium 2009: Resources, Production and Demand , a joint study by the OECD/NEA and the IAEA, carried out in co-operation with their member countries and states and commonly referred to as the ''Red Book''. This is the 23r

  19. Experimental Drug Shows Promise in Lowering Cholesterol, Heart Attack Risk

    Science.gov (United States)

    Experimental Drug Shows Promise in Lowering Cholesterol, Heart Attack Risk Adding the 'investigational biologic' evolocumab to statin therapy works better, study says To use the sharing features on this page, please enable ...

  20. Astronaut John Fabian show off signs on aft flight deck

    Science.gov (United States)

    1985-01-01

    Astronaut John Fabian, payload specialist, show off a series of signs on the aft flight deck of Discovery, from whose payload bay three communications satellites were deployed. The sign reads 'We deliver and deliver and deliver...'

  1. 22 CFR 1421.16 - Showing of interest.

    Science.gov (United States)

    2010-04-01

    ...Showing of interest means evidence of membership in a labor organization; employees' signed and dated authorization cards or petitions authorizing a labor...employees' signed and dated petitions or cards indicating that they no longer...

  2. Skin Patch Shows Promise in Easing Peanut Allergy

    Science.gov (United States)

    Skin Patch Shows Promise in Easing Peanut Allergy Wearable device appears to 'educate' cells not to react ... 2015 SUNDAY, Feb. 22, 2014 (HealthDay News) -- A wearable patch that safely and gradually exposes the body ...

  3. Salivary Gland Biopsy Shows Promise to Helping to Diagnose Parkinson's

    Science.gov (United States)

    Parkinson's HelpLine Learn More Educational Materials Do you want to know more about Parkinson's? PDF's materials provide ... Gland Biopsy Shows Promise to Helping to Diagnose Parkinson’s - Mar 20 2014 A simple outpatient procedure that ...

  4. When Should Zero Be Included on a Scale Showing Magnitude?

    Science.gov (United States)

    Kozak, Marcin

    2011-01-01

    This article addresses an important problem of graphing quantitative data: should one include zero on the scale showing magnitude? Based on a real time series example, the problem is discussed and some recommendations are proposed.

  5. Face Scans Show How Fast a Person Is Aging

    Science.gov (United States)

    Face Scans Show How Fast a Person Is Aging Study says images more reliable than blood tests ... 2015 TUESDAY, March 31, 2015 (HealthDay News) -- Every face tells a story, and that story apparently includes ...

  6. Study Shows Flu Vaccination Prevents Hospitalizations in Older Adults

    Science.gov (United States)

    ... Newsletters Study Shows Flu Vaccination Prevents Hospitalizations in Older Adults Language: English Español Recommend on Facebook Tweet ... that flu vaccination can be less effective in older adults,� said Dr. Keipp Talbot, lead author of ...

  7. Malaria Vaccine Shows Promise in Shielding African Children

    Science.gov (United States)

    ... nlm.nih.gov/medlineplus/news/fullstory_152180.html Malaria Vaccine Shows Promise in Shielding African Children Even ... people, mostly in Africa, die from mosquito-borne malaria each year. Most of those victims are children, ...

  8. Giant primary angiosarcoma of the small intestine showing severe sepsis

    OpenAIRE

    Takahashi, Mizuna; Ohara, Masanori; Kimura, Noriko; Domen, Hiromitsu; Yamabuki, Takumi; Komuro, Kazuteru; Tsuchikawa, Takahiro; Hirano, Satoshi; Iwashiro, Nozomu

    2014-01-01

    Primary malignant tumors of the small intestine are rare, comprising less than 2% of all gastrointestinal tumors. An 85-year-old woman was admitted with fever of 40??°C and marked abdominal distension. Her medical history was unremarkable, but blood examination showed elevated inflammatory markers. Abdominal computed tomography showed a giant tumor with central necrosis, extending from the epigastrium to the pelvic cavity. Giant gastrointestinal stromal tumor of the small intestine commu...

  9. Simple pneumonediastinum showing the findings of pleural effusion

    International Nuclear Information System (INIS)

    We experienced a case of simple pneumonediastinum showing the findings of pleural effusion. Frontal chest radiography showed not only pneumonediastinum but also diffuse haziness with sharp medical margin on left lower lung field, blunting of costophrenic angle, and indistinct contour of diaphragm simulating pleural effusion. CT scan confirmed that these findings arose from the displaced pleura and the associated compression atelectasis by loculated air on the anterior mediastinum

  10. Effective Marketing Strategies to Attract Business Visitors at Trade Shows

    OpenAIRE

    Mei-Chin Chu; Sui-Ming Chiu

    2013-01-01

    Trade shows have been the focus of recent research as constituting one of the most effective marketing strategies.Related issues have been discussed extensively in the literature. How to achieve better performance is central tothese discussions. Studies on the key factors that influence trade show performance have focused mainly onsubjective opinions from the perspective of the staff at exhibitions. In this study, we explored the key criteria fora business visitor in selecting suppliers at a ...

  11. The Effectiveness of Trade Shows in Global Competition

    Directory of Open Access Journals (Sweden)

    JONIDA KELLEZI

    2013-06-01

    Full Text Available Trade shows industry has experienced a rapid growth during the last years. They are considered as a vital communication technique especially for those companies that operate in international markets and that aim to reach specific audiences. Making them an integral part of the marketing communication strategy enables companies in: developing customer relationships; offering possibilities for sales and sales promotion; undertaking and maintaining good international business relations; monitoring international competition as well as minimizing entry barriers in new markets. During the last years, many Albanian companies that operate in foreign businesses have started to engage in trade shows. Face to face meetings with their potential customers and direct competitors are among the most important reasons for investing in this marketing tool. Even though the literature regarding trade shows effectiveness is increasing constantly, research on its effectiveness is still limited. Therefore, the aim of this paper is to study the effectiveness of trade shows as a marketing communication tool. More specifically, it is focused in studying the usage of trade shows by Albanian companies when competing on international markets.

  12. The presentation of science in everyday life: the science show

    Science.gov (United States)

    Watermeyer, Richard

    2013-09-01

    This paper constitutes a case-study of the `science show' model of public engagement employed by a company of science communicators focused on the popularization of science, technology, engineering and mathematics (STEM) subject disciplines with learner constituencies. It examines the potential of the science show to foster the interest and imagination of young learners in STEM; challenge popular pre/misconceptions of science and scientists; reveal the broadness, plurality and everyday relevance of science; and induce a more fluent and equitable science nexus between expert and non-expert or learner groups. Discussion focuses on conversations with members of a UK and university based science communication outfit who comment on the potential of the science show as a model of non-formal science education and science engagement and the necessary conditions for its success.

  13. Five Kepler target stars that show multiple transiting exoplanet candidates

    CERN Document Server

    Steffen, Jason H; Borucki, William J; Buchhave, Lars A; Caldwell, Douglas A; Cochran, William D; Endl, Michael; Fabrycky, Daniel C; Fressin, François; Ford, Eric B; Fortney, Jonathan J; Haas, Michael J; Holman, Matthew J; Isaacson, Howard; Jenkins, Jon M; Koch, David; Latham, David W; Lissauer, Jack J; Moorhead, Althea V; Morehead, Robert C; Marcy, Geoffrey; MacQueen, Phillip J; Quinn, Samuel N; Ragozzine, Darin; Rowe, Jason F; Sasselov, Dimitar D; Seager, Sara; Torres, Guillermo; Welsh, William F

    2010-01-01

    We present and discuss five candidate exoplanetary systems identified with the Kepler spacecraft. These five systems show transits from multiple exoplanet candidates. Should these objects prove to be planetary in nature, then these five systems open new opportunities for the field of exoplanets and provide new insights into the formation and dynamical evolution of planetary systems. We discuss the methods used to identify multiple transiting objects from the Kepler photometry as well as the false-positive rejection methods that have been applied to these data. One system shows transits from three distinct objects while the remaining four systems show transits from two objects. Three systems have planet candidates that are near mean motion commensurabilities - two near 2:1 and one just outside 5:2. We discuss the implications that multitransiting systems have on the distribution of orbital inclinations in planetary systems, and hence their dynamical histories; as well as their likely masses and chemical compos...

  14. Uni Dufour | Ig Nobel Show with Marc Abrahams | 7 May

    CERN Multimedia

    2013-01-01

    On 7 May, Marc Abrahams, founder of the Ig Nobel Prize, will give an "Ig Nobel show", in English at Uni Dufour. The Ig Nobel Prizes are an American parody of the Nobel Prizes. In early October of each year, they are awarded to ten unusual or trivial achievements in scientific research. The stated aim of the prizes is to "first make people laugh, and then make them think". Marc Abrahams will introduce this funny and dynamic evening with a short presentation before handing over to a selection of recipients. The show is free and open to all. Tuesday 7 May Ig Nobel Show 6:30 p.m. - Room U600 Uni Dufour

  15. The Biochemistry Show: a new and fun tool for learning

    Directory of Open Access Journals (Sweden)

    A.H Ono

    2006-07-01

    Full Text Available The traditional methods to teach biochemistry in most universities are based on the memorization of chemical structures,  biochemical  pathways  and  reagent  names,  which  is  many  times  dismotivating  for  the  students.  We presently describe an innovative, interactive and alternative method for teaching biochemistry to medical and nutrition undergraduate students, called the Biochemistry Show (BioBio Show.The Biobio show is based on active participation of the students. They are divided in groups and the groups face each other. One group faces another one group at a time, in a game based on true or false questions that involve subjects of applied biochemistry (exercise, obesity, diabetes, cholesterol, free radicals, among others. The questions of the Show are previously elaborated by senior students. The Biobio Show has four phases, the first one is a selection exam, and from the second to the fourth phase, eliminatory confrontations happen. On a confrontation, the first group must select a certain quantity of questions for the opponent to answer.  The group who choses the questions must know how to answer and justify the selected questions. This procedure is repeated on all phases of the show. On the last phase, the questions used are taken from an exam previously performed by the students: either the 9-hour biochemistry exam (Sé et al. A 9-hour biochemistry exam. An iron man competition or a good way of evaluating undergraduate students? SBBq 2005, abstract K-6 or the True-or-False exam (TFE (Sé et al. Are tutor-students capable of writing good biochemistry exams? SBBq 2004, abstract K-18. The winner group receives an extra 0,5 point on the final grade. Over 70% of the students informed on a questionnaire that the Biobio Show is a valuable tool for learning biochemistry.    That is a new way to enrich the discussion of biochemistry in the classroom without the students getting bored. Moreover, learning is powered by critical and applied biochemistry emphasis during the Biobio Show. Financial Support: CNPq and PIBIC.

  16. Ohio State study shows how chronic inflammation can cause leukemia

    Science.gov (United States)

    A hormone-like substance produced by the body to promote inflammation can cause an aggressive form of leukemia when present at high levels, according to a new study by researchers at the Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute. The study shows that high levels of interleukin-15 (IL-15) alone can cause large granular lymphocytic (LGL) leukemia, a rare and usually fatal form of cancer, in an animal model. The researchers also developed a treatment for the leukemia that showed no discernible side effects in the animal model.

  17. CERN cars drive by the Geneva Motor Show

    CERN Multimedia

    CERN Bulletin

    2011-01-01

    One of CERN's new gas-fuelled cars was a special guest at the press days of the Geneva motor show this year. The car enjoyed a prominent position on the Gazmobil stand, right next to the latest Mazeratis and Ferraris. Journalists previewing the motor show could discover CERN's support for green technologies and also find out more about the lab - home to the fastest racetrack on the planet, with protons in the LHC running at 99.9999991% of the speed of light.    

  18. Condorcet's principle and the strong no-show paradoxes

    OpenAIRE

    Duddy, Conal

    2012-01-01

    We consider two no-show paradoxes, in which a voter obtains a preferable outcome by abstaining from a vote. One arises when the casting of a ballot that ranks a candidate in first causes that candidate to lose the election. The other arises when a ballot that ranks a candidate in last causes that candidate to win. We show that when there are at least four candidates and when voters may express indifference, every voting rule satisfying Condorcet's principle must generate both of these paradoxes.

  19. El reality show a la hora de la merienda

    Directory of Open Access Journals (Sweden)

    Lic. Rosa María Ganga Ganga

    2000-01-01

    Full Text Available Los programas de testimonio, inscritos dentro del género televisivo del Reality Show, son una variante del más amplio subgénero del Talk Show y tienen ya una cierta tradición en nuestro país. El presente trabajo se centrará en este tipo de programas de testimonio que basan su estrategia discursiva en la presentación y representación del relato autobiográfico del hombre o la mujer anónimos, integrándose de esta forma en las corrientes más recientes de la sociología y la historiografía, y persigue esclarecer algunas de sus características y funciones, especialmente su función socializadora, a través del mecanismo biográfico y del concepto de habitus tomado de Pierre Bourdieu.

  20. "Country Life"? Rurality, Folk Music and "Show of Hands"

    Science.gov (United States)

    Yarwood, Richard; Charlton, Clive

    2009-01-01

    This paper examines the contribution of folk music to understanding the dynamic, fluid and multi-experiential nature of the countryside. Drawing from literature on the geographies of music, it examines the work of "Show of Hands", a contemporary folk band from Devon in England. Three areas are studied. First, the paper examines the musical style…

  1. New Drug for Crohn's Disease Shows Early Promise

    Science.gov (United States)

    New Drug for Crohn's Disease Shows Early Promise But findings are preliminary, experts point out To use the sharing features on this page, please ... may quickly quash symptoms of the digestive disorder Crohn's disease -- at least for the short term, an early ...

  2. The role of prosody in a Czech talk-show.

    Czech Academy of Sciences Publication Activity Database

    Havlík, Martin

    Amsterdam : Benjamins, 2012 - (Lorda, C.; Zabalbeascoa, P.), s. 143-160 ISBN 978-90-272-1032-6. - (Dialogue Studies. 15) R&D Projects: GA AV ?R KJB900610701; GA ?R GA405/09/2028 Institutional research plan: CEZ:AV0Z90610518 Keywords : prosody * TV talk-show * conversation analysis Subject RIV: AI - Linguistics

  3. Graduate Students' Pay and Benefits Vary Widely, Survey Shows

    Science.gov (United States)

    June, Audrey Williams

    2008-01-01

    Graduate students face an array of choices when evaluating compensation-and-benefits packages that make comparisons difficult. A "Chronicle" survey shows that the offers to teaching assistants and research assistants vary widely. Some institutions cover 100 percent of graduate students' tuition, while others waive only a portion. It is possible to…

  4. Teaching Job Interviewing Skills with the Help of Television Shows

    Science.gov (United States)

    Bloch, Janel

    2011-01-01

    Because of its potential for humor and drama, job interviewing is frequently portrayed on television. This article discusses how scenes from popular television series such as "Everybody Loves Raymond," "Friends," and "The Mary Tyler Moore Show" can be used to teach effective job interview skills in business communication courses. Television…

  5. Graphene oxide immobilized enzymes show high thermal and solvent stability

    Science.gov (United States)

    Hermanová, So?a; Zarevúcká, Marie; Bouša, Daniel; Pumera, Martin; Sofer, Zden?k

    2015-03-01

    The thermal and solvent tolerance of enzymes is highly important for their industrial use. We show here that the enzyme lipase from Rhizopus oryzae exhibits exceptionally high thermal stability and high solvent tolerance and even increased activity in acetone when immobilized onto a graphene oxide (GO) nanosupport prepared by Staudenmaier and Brodie methods. We studied various forms of immobilization of the enzyme: by physical adsorption, covalent attachment, and additional crosslinking. The activity recovery was shown to be dependent on the support type, enzyme loading and immobilization procedure. Covalently immobilized lipase showed significantly better resistance to heat inactivation (the activity recovery was 65% at 70 °C) in comparison with the soluble counterpart (the activity recovery was 65% at 40 °C). Physically adsorbed lipase achieved over 100% of the initial activity in a series of organic solvents. These findings, showing enhanced thermal stability and solvent tolerance of graphene oxide immobilized enzyme, will have a profound impact on practical industrial scale uses of enzymes for the conversion of lipids into fuels.The thermal and solvent tolerance of enzymes is highly important for their industrial use. We show here that the enzyme lipase from Rhizopus oryzae exhibits exceptionally high thermal stability and high solvent tolerance and even increased activity in acetone when immobilized onto a graphene oxide (GO) nanosupport prepared by Staudenmaier and Brodie methods. We studied various forms of immobilization of the enzyme: by physical adsorption, covalent attachment, and additional crosslinking. The activity recovery was shown to be dependent on the support type, enzyme loading and immobilization procedure. Covalently immobilized lipase showed significantly better resistance to heat inactivation (the activity recovery was 65% at 70 °C) in comparison with the soluble counterpart (the activity recovery was 65% at 40 °C). Physically adsorbed lipase achieved over 100% of the initial activity in a series of organic solvents. These findings, showing enhanced thermal stability and solvent tolerance of graphene oxide immobilized enzyme, will have a profound impact on practical industrial scale uses of enzymes for the conversion of lipids into fuels. Electronic supplementary information (ESI) available. See DOI: 10.1039/c5nr00438a

  6. Imprinted genes show unique patterns of sequence conservation

    OpenAIRE

    Helms Volkhard; Bieg Matthias; Hutter Barbara; Paulsen Martina

    2010-01-01

    Abstract Background Genomic imprinting is an evolutionary conserved mechanism of epigenetic gene regulation in placental mammals that results in silencing of one of the parental alleles. In order to decipher interactions between allele-specific DNA methylation of imprinted genes and evolutionary conservation, we performed a genome-wide comparative investigation of genomic sequences and highly conserved elements of imprinted genes in human and mouse. Results Evolutionarily conserved elements i...

  7. Salomon Bros. survey shows flat upstream spending for 1992

    International Nuclear Information System (INIS)

    The yearly survey by Salomon Bros., New York of upstream spending by the international petroleum industry shows little change for 1992 from 1991. This paper reports that a substantial shift from U.S. to non U.S. exploration and production will continue, the firm's 10th and largest survey-241 companies-shows only 1 1.3% increase in worldwide exploration and production spending to $53.7 billion in 1992 from $53.1 billion estimated in 1991. The amount estimated for last year's spending is less than the sum forecast at midyear 1991. That, in turn, is lower than what was budgeted for 1991 in December 1990. Budgets in 1991 were significantly underspent in the U.S. and Canada but not elsewhere

  8. Network Affordances: Unpredictable parameters of a Hong Kong SPEED SHOW

    DEFF Research Database (Denmark)

    Samson, Audrey; Soon, Winnie

    2015-01-01

    This paper examines the notion of network affordance within the context of network art. Building on Gibson's theory (Gibson, 1979) we understand affordance as the perceived and actual parameters of a thing. We expand on Gaver's affordance of predictability (Gaver, 1996) to include ecological and computational parameters of unpredictability. We illustrate the notion of unpredictability by considering four specific works that were included in a network art exhibiton, SPEED SHOW [2.0] Hong Kong. The paper discusses how the artworks are contingent upon the parameteric relations (Parisi, 2013), of the network. We introduce network affordance as a dynamic framework that could articulate the experienced tension arising from the (visible) symbolic representation of computational processes and its hidden occurrences. We base our proposal on the experience of both organising the SPEED SHOW and participating in it as artists, and what we perceived as the lack of concepts available to express how the works modulated the space and the experience of the network.

  9. [A system for capturing and showing micrographs of genetics experiments].

    Science.gov (United States)

    Li, Jian; Pan, Shen-Yuan; Zhu, Ming-Li; Gao, Tian-Hui; Liang, Qing-Shan; Liu, Hong-Xia

    2004-07-01

    A system for capturing and showing micrographs of genetics was designed with Microsoft Visual Basic 6.0. The system includes many functions such as capturing and editing images, typing and editing text, teaching experiments, showing images, image retrieval, database management, system maintenance and help, all of them were developed with the form of Windows. The system could collect images not only from image-grabber card in real-time but also from scanner, digital camera, clipboard and files. After utilizing the image compression technology, the images will be saved in database along with experiment instruction. With all the features referred above, the system can be used as a wonderful assistant both for the teaching of genetics experiments and for the students' learning by themselves. PMID:15640051

  10. Exhibitor satisfaction in business-to-business trade shows

    OpenAIRE

    Michael Reinhold; Stephan Reinhold; Christian Schmitz

    2010-01-01

    Tradeshows are an essential instrument in the marketing of goods and services. Thus, the fair and tradeshow business has become a multi-billion dollar industry, in which trade fair organizers earn the biggest share of sales with exhibitors, paying fees for exhibition services. In order to increase service quality on trade shows, trade fair organizers strive for achieving a high level of exhibitor satisfaction. Despite its major importance for the fair and tradeshow industry, instruments to po...

  11. About Goto's method showing surjectivity of word maps

    OpenAIRE

    Elkasapy, Abdelrhman; Thom, Andreas

    2012-01-01

    Let F be the free group on two letters. For {\\omega} \\in F we study the associated word map {\\omega}: SU(n) \\times SU(n) \\rightarrow SU(n). Extending a method of Goto, we show that for {\\omega} not in the second derived subgroup F^(2) of F, there are infinitely many n \\in N such that the associated word map {\\omega} : SU(n) \\times SU(n) \\rightarrow SU(n) is surjective.

  12. What to Show? - Automatic Stream Selection among Multiple Sensors

    OpenAIRE

    Emonet, Re?mi; Oberzaucher, Elisabeth; Odobez, Jean-marc

    2014-01-01

    The installation of surveillance networks has been growing exponentially in the last decade. In practice, videos from large surveillance networks are almost never watched, and it is frequent to see surveillance video wall monitors showing empty scenes. There is thus a need to design methods to continuously select streams to be shown to human operators. This paper addresses this issue and make three main contributions: it introduces and investigates, for the first time in the literature, the l...

  13. Identifying factors affecting consumers purchase incidence at retail trade shows

    OpenAIRE

    Tafesse, Wondwesen; Korneliussen, Tor

    2012-01-01

    The purpose of this article is to examine variables influencing purchase incidences at retail trade shows. To this end, retailer and consumer related antecedent variables are proposed. The retailer related variables are represented by store environmental cues of sales staff services, store atmosphere and product assortment. The consumer related variables are represented by impulse buying tendency and perceived time pressure. Drawing on relevant literature, hypotheses are developed to link eac...

  14. The Effectiveness of Trade Shows in Global Competition

    OpenAIRE

    JONIDA KELLEZI

    2013-01-01

    Trade shows industry has experienced a rapid growth during the last years. They are considered as a vital communication technique especially for those companies that operate in international markets and that aim to reach specific audiences. Making them an integral part of the marketing communication strategy enables companies in: developing customer relationships; offering possibilities for sales and sales promotion; undertaking and maintaining good international business relations; monitorin...

  15. Mice lacking neuropeptide Y show increased sensitivity to cocaine

    DEFF Research Database (Denmark)

    SØrensen, Gunnar; Woldbye, David P D

    2012-01-01

    There is increasing data implicating neuropeptide Y (NPY) in the neurobiology of addiction. This study explored the possible role of NPY in cocaine-induced behavior using NPY knockout mice. The transgenic mice showed a hypersensitive response to cocaine in three animal models of cocaine addiction. Whether this is due to an observed compensatory increase in striatal dopamine transporter binding or an anxiogenic phenotype of the transgenic mice remains to be determined.

  16. Case of Cronkhite Canada syndrome shows improvement with enteral supplements.

    Science.gov (United States)

    Lipin, S P; Paul, Baby; Nazimudeen, E; Jacob, Baiju Sam

    2012-04-01

    Cronkhite-Canada syndrome (CCS) is a rare nonfamilial syndrome characterized by marked epithelial disturbances in the GI tract and epidermis. Cronkhite and Canada described the first 2 cases in 1955. Since then only about 450 cases have been reported worldwide. Here we report a 33 year old Indian male admitted with history of loose stools and abdominal pain, loose stools associated with weight loss, generalized weakness, significant amount of hair loss as well as hyperpigmentation of his palms and soles. On subsequent days of the stay in the hospital he developed hypogeusia and showed onychodystrophy. Endoscopy of Upper GI and Lower GI tract revealed severe gastroduodenitis with polyp in duodenum and multiple polyps whole throughout the colon respectively. Biopsy report showed eosinophilic gastritis and hamartomatous polyps in colon as well as in duodenum. He was started on high protein supplement, proton pump inhibitors and zinc-vitamin supplement and he showed a complete recovery in symptoms within 5 months of initiation of treatment. Hence, early diagnosis and initiation of appropriate treatment helped the patient to improve in symptoms from such a rare disease. PMID:23029747

  17. FIVE KEPLER TARGET STARS THAT SHOW MULTIPLE TRANSITING EXOPLANET CANDIDATES

    International Nuclear Information System (INIS)

    We present and discuss five candidate exoplanetary systems identified with the Kepler spacecraft. These five systems show transits from multiple exoplanet candidates. Should these objects prove to be planetary in nature, then these five systems open new opportunities for the field of exoplanets and provide new insights into the formation and dynamical evolution of planetary systems. We discuss the methods used to identify multiple transiting objects from the Kepler photometry as well as the false-positive rejection methods that have been applied to these data. One system shows transits from three distinct objects while the remaining four systems show transits from two objects. Three systems have planet candidates that are near mean motion commensurabilities-two near 2:1 and one just outside 5:2. We discuss the implications that multi-transiting systems have on the distribution of orbital inclinations in planetary systems, and hence their dynamical histories, as well as their likely masses and chemical compositions. A Monte Carlo study indicates that, with additional data, most of these systems should exhibit detectable transit timing variations (TTVs) due to gravitational interactions, though none are apparent in these data. We also discuss new challenges that arise in TTV analyses due to the presence of more than two planets in a system.

  18. AirShow 1.0 CFD Software Users' Guide

    Science.gov (United States)

    Mohler, Stanley R., Jr.

    2005-01-01

    AirShow is visualization post-processing software for Computational Fluid Dynamics (CFD). Upon reading binary PLOT3D grid and solution files into AirShow, the engineer can quickly see how hundreds of complex 3-D structured blocks are arranged and numbered. Additionally, chosen grid planes can be displayed and colored according to various aerodynamic flow quantities such as Mach number and pressure. The user may interactively rotate and translate the graphical objects using the mouse. The software source code was written in cross-platform Java, C++, and OpenGL, and runs on Unix, Linux, and Windows. The graphical user interface (GUI) was written using Java Swing. Java also provides multiple synchronized threads. The Java Native Interface (JNI) provides a bridge between the Java code and the C++ code where the PLOT3D files are read, the OpenGL graphics are rendered, and numerical calculations are performed. AirShow is easy to learn and simple to use. The source code is available for free from the NASA Technology Transfer and Partnership Office.

  19. Strange culinary cncounters: : stranger fetishism in cooking shows

    DEFF Research Database (Denmark)

    Leer, Jonatan; Kjær, Katrine Meldgaard

    Strange Culinary Encounters: Stranger Fetishism in Cooking Shows In this paper, we will examine the ways in which the encountering of 'other' food cultures is played out in the two travelogue cooking shows Gordon's Great Escape and Jamie's Italian Escape, arguing that despite their ‘noble’ intentions and ‘enlightened’ cosmopolitan approach to meeting the other (culinary culture), ultimately, Jamie and Gordon's respective culinary adventures work to create a social hierarchy in their own favor. Inspired by Sara Ahmed’s work on stranger fetishism, we will investigate how the two protagonist chefs Jamie Oliver and Gordon Ramsay imagine, meet and evaluate the ‘other’ food cultures in these programs, paying special attention to how the encounter with the local Indian and Italian is imagined to be a gateway to an authentic and/or primitive experience. To unpack the programs and the experiences within them, we use critical discourse analysis and the readings strategies of cultural studies and postcolonialtheory and a focus on how classic, colonial power structures are reproduced in contemporary, globalized food culture. We will consider what potential this methodological framework holds for unpacking cultural encounters, and show how we have used it to deconstruct how ‘authentic’ food is done and met in Gordon's Great Escape and Jamie's Italian Escape. In doing so, we will argue that this way of reading cultural encounters ultimately opens for an alternative understanding of the central concepts of the ‘strange’, the ‘encounter’ and ideas of authenticity and, importantly, how the three intersect.

  20. Graphene oxide immobilized enzymes show high thermal and solvent stability.

    Science.gov (United States)

    Hermanová, So?a; Zarevúcká, Marie; Bouša, Daniel; Pumera, Martin; Sofer, Zden?k

    2015-03-19

    The thermal and solvent tolerance of enzymes is highly important for their industrial use. We show here that the enzyme lipase from Rhizopus oryzae exhibits exceptionally high thermal stability and high solvent tolerance and even increased activity in acetone when immobilized onto a graphene oxide (GO) nanosupport prepared by Staudenmaier and Brodie methods. We studied various forms of immobilization of the enzyme: by physical adsorption, covalent attachment, and additional crosslinking. The activity recovery was shown to be dependent on the support type, enzyme loading and immobilization procedure. Covalently immobilized lipase showed significantly better resistance to heat inactivation (the activity recovery was 65% at 70 °C) in comparison with the soluble counterpart (the activity recovery was 65% at 40 °C). Physically adsorbed lipase achieved over 100% of the initial activity in a series of organic solvents. These findings, showing enhanced thermal stability and solvent tolerance of graphene oxide immobilized enzyme, will have a profound impact on practical industrial scale uses of enzymes for the conversion of lipids into fuels. PMID:25757536

  1. Strange Culinary Encounters: Stranger Fetishism in Cooking Shows

    DEFF Research Database (Denmark)

    Leer, Jonatan; Kjær, Katrine Meldgaard

    Strange Culinary Encounters: Stranger Fetishism in Cooking Shows In this paper, we will examine the ways in which the encountering of 'other' food cultures is played out in the two travelogue cooking shows Gordon's Great Escape and Jamie's Italian Escape, arguing that despite their ‘noble’ intentions and ‘enlightened’ cosmopolitan approach to meeting the other (culinary culture), ultimately, Jamie and Gordon's respective culinary adventures work to create a social hierarchy in their own favor. Inspired by Sara Ahmed’s work on stranger fetishism, we will investigate how the two protagonist chefs Jamie Oliver and Gordon Ramsay imagine, meet and evaluate the ‘other’ food cultures in these programs, paying special attention to how the encounter with the local Indian and Italian is imagined to be a gateway to an authentic and/or primitive experience. To unpack the programs and the experiences within them, we use critical discourse analysis and the readings strategies of cultural studies and postcolonialtheory and a focus on how classic, colonial power structures are reproduced in contemporary, globalized food culture. We will consider what potential this methodological framework holds for unpacking cultural encounters, and show how we have used it to deconstruct how ‘authentic’ food is done and met in Gordon's Great Escape and Jamie's Italian Escape. In doing so, we will argue that this way of reading cultural encounters ultimately opens for an alternative understanding of the central concepts of the ‘strange’, the ‘encounter’ and ideas of authenticity and, importantly, how the three intersect.

  2. Five kepler target stars that show multiple transiting exoplanet candidates

    DEFF Research Database (Denmark)

    Steffen..[], Jason H.; Batalha, N. M.

    2010-01-01

    We present and discuss five candidate exoplanetary systems identified with the Kepler spacecraft. These five systems show transits from multiple exoplanet candidates. Should these objects prove to be planetary in nature, then these five systems open new opportunities for the field of exoplanets and provide new insights into the formation and dynamical evolution of planetary systems. We discuss the methods used to identify multiple transiting objects from the Kepler photometry as well as the false-positive rejection methods that have been applied to these data. One system shows transits from three distinct objects while the remaining four systems show transits from two objects. Three systems have planet candidates that are near mean motion commensurabilities—two near 2:1 and one just outside 5:2. We discuss the implications that multi-transiting systems have on the distribution of orbital inclinations in planetary systems, and hence their dynamical histories, as well as their likely masses and chemical compositions. A Monte Carlo study indicates that, with additional data, most of these systems should exhibit detectable transit timing variations (TTVs) due to gravitational interactions, though none are apparent in these data. We also discuss new challenges that arise in TTV analyses due to the presence of more than two planets in a system.

  3. Fatigue crack growth rate determination during pre-cracking of fracture toughness specimens

    International Nuclear Information System (INIS)

    Fatigue crack growth rates were measured during pre-cracking of standard (Compact Tension) and non-standard (Charpy V-notch and Three-Point-Bend) fracture toughness specimens of two ferritic steels. Crack growth rates from the specimens were then compared with the results obtained from Compact Tension specimens following the procedures of ASTM designated standard test method. The experimental results and their analysis suggested the possibility of generating respective material crack growth rate data as a bonus during fatigue precracking of fracture toughness specimens including Charpy V-notch and Three-Point-Bend specimens. (author)

  4. Strobes: pyrotechnic compositions that show a curious oscillatory combustion.

    Science.gov (United States)

    Corbel, Justine M L; van Lingen, Joost N J; Zevenbergen, John F; Gijzeman, Onno L J; Meijerink, Andries

    2013-01-01

    Strobes are pyrotechnic compositions which show an oscillatory combustion; a dark phase and a flash phase alternate periodically. The strobe effect has applications in various fields, most notably in the fireworks industry and in the military area. All strobe compositions mentioned in the literature were discovered by trial and error methods and the mechanisms involved remain unclear. Many oscillatory systems such as Belousov-Zhabotinsky reactions, cool flames, self-propagating high-temperature synthesis have been observed and theories developed to elucidate their unstable behavior based on chemical interactions or based on physical processes. These systems are compared to experimental observations made on strobe mixtures. PMID:23255499

  5. Twin boundaries showing very large deviations from the twinning plane

    International Nuclear Information System (INIS)

    In deformation twinning, twin boundaries (TBs) should coincide with the twinning plane. Here we show that the TBs of the most common twinning mode in hexagonal close-packed metals, {101¯2}?101¯1¯?, may not lie on the {101¯2} twinning plane. Examinations using transmission electron microscopy (TEM) reveal that the TBs in Co and Mg deviate significantly from the {101¯2} plane. High-resolution TEM confirms that the incoherent TBs entirely depart from the twinning plane with a magnitude greater than 45°.

  6. Multiple nontuberculous scrofulodermas showing dramatic response to clarithromycin.

    Science.gov (United States)

    Parimalam, Kumar; Senthil, G; Vinnarasan, M; Arumugakani, V; Amutha, B M; Lalitha, S; Swarna, S

    2015-01-01

    Atypical mycobacteria are distinct from the Mycobacterium tuberculosis. Mycobacterium chelonae, a non-pigment producing rapid grower, can be found in many cutaneous sites; infection occurs most commonly after skin trauma from surgery, injections, or minor injuries. In immune competent patients, the infection is more frequently localized as a cellulitis or a nodule, whereas, in the immunocompromised patient, dissemination (more than five lesions) can occur. Because the organism is resistant to antituberculous therapy, abscess can develop and follow a chronic, indolent course. We report a case of multiple scrofuloderma due to nontuberculous infection caused by M. chelonae showing dramatic response to clarithromycin. PMID:25657914

  7. CERN's gamble shows perils, rewards of playing the odds

    CERN Multimedia

    Seife, C

    2000-01-01

    Data from LEP has a three to four sigma certainty that the Higgs Boson has been seen. To declare a discovery though, normally five sigma is required. This article examines other occasions where even with this degree of certainty, the results finally turned out to be spurious (3 pages).

  8. SNA Releases Back to School Nutrition Trends Report: Results Show What Schools Are Doing to Increase Healthy Options for Kids

    Science.gov (United States)

    Curriculum Review, 2008

    2008-01-01

    This article talks about the School Nutrition Association's 2008 Back to School Nutrition Trends Report that was released on August 19. According to the report, the trend towards more healthful school meal choices continues this fall with district nutrition programs emphasizing whole grains, fruits, and vegetables while cutting back on trans fats,…

  9. Oilsands for the USA : while environmental groups ask for a shutdown, new study shows significant resulting economic benefits in America

    International Nuclear Information System (INIS)

    The United States is beginning to appreciate the value of having massive oil sands resources located in relatively close proximity to their northern border. This article discussed a recent study conducted by the Canadian Energy Research Institute (CERI) to assess the impact of Canada's oil sands development on the economy of the United States. The study forecasted that the demand for oil sands-related goods and services from American companies will continue to increase as the industry expands. The top national-level goods and services impacts will be derived from increases in manufacturing; finance; insurance; real estate; and professional, scientific, and technical services. Accommodation and food services in the United States will also benefit from the growth of the oil sands industry. The United States may not risk pushing ahead with strict carbon-cutting legislation targeting the oil sands when policy-makers consider the potential impacts of Canada selling its resources to China. 1 fig.

  10. Drilling and production - Economics show CO2 EOR potential

    Science.gov (United States)

    Dubois, M.K.; Byrnes, A.P.

    2000-01-01

    CO2 EOR may be the key to recovering hundreds of millions of bbl of trapped oil from the mature fields in central Kansas. A simple model aided in assessing the economics of CO2 EOR for central Kansas and the Midcontinent. The model used CO2 Prophet, a DOE freeware reservoir numerical simulation program, to determine reservoir performance, including injected and produced fluid rates, and CO2 utilization. Economic parameters, e.g., oil price, CO2 costs, capital costs, net revenue interest, production taxes, and lease operating expenses, are typical for anticipated conditions in the region and present price climate. Preliminary economic analysis shows that CO2 EOR should give an internal rate of return (IRR) > 20%, before income tax, assuming oil sells for $20/bbl, CO2 costs $1/million cu ft, and gross utilization is 10 million cu ft of CO2/bbl of oil recovered. If the CO2 is reduced to $0.75/million cu ft, an oil price of $17/bbl yields an IRR of 20%. Reservoir and economic modeling shows that IRR is most sensitive to oil price and CO2 cost.

  11. Manual restraint and shows of force: the City-128 study.

    Science.gov (United States)

    Bowers, Len; Van Der Merwe, Marie; Paterson, Brodie; Stewart, Duncan

    2012-02-01

    Manual restraint is used to manage disturbed behaviour by patients. This study aimed to assess the relationship of manual restraint and show of force to conflict behaviours, the use of containment methods, service environment, physical environment, patient routines, staff characteristics, and staff group variables. Data from a multivariate, cross-sectional study of 136 acute psychiatric wards in England were used to conduct this analysis. Manual restraint was used less frequently on English acute psychiatric wards (0.20 incidents per day) than show of force (0.28 incidents per day). Both were strongly associated with the proportion of patients subject to legal detention, aggressive behaviours, and the enforcement of treatment and detention. Medical, nursing, and security guard staff provision were associated in different ways with variations in the use of these coercive interventions. An effective ward structure of rules and routines was associated with less dependence on these control methods. Training for manual restraint should incorporate the scenarios of attempted absconding and enforcement of treatment, as well as violent behaviour. Attempts to lessen usage of these interventions could usefully focus on increasing the availability of medical staff to patients, reducing reliance on security guards and establishing a good ward structure. PMID:21733054

  12. Two cases of Tolosa-Hunt syndrome showing interesting CT findings

    International Nuclear Information System (INIS)

    CT showed the lesion at the orbital apex in both of the 2 cases of Tolosa-Hunt syndrome. Steroid therapy resulted in improvement of clinical symptoms and regression of the lesion which was confirmed by CT. (Chiba, N.)

  13. La Realidad Simulada. Una Crítica del reality show / The simmulation of Reality. A critic of the reality show.

    Scientific Electronic Library Online (English)

    Leonardo, Ordóñez Díaz.

    2005-05-30

    Full Text Available El reality show es el formato televisivo más exitoso de los últimos años. Este artículo efectúa una exploración en torno a dicho formato articulada en tres partes. Primero, se estudiará la tensión que los realities generan entre la representación como esquema estético tradicional y la simulación com [...] o esquema estético emergente; luego, se detallará la manera en que los realities participan en la producción del mundo como imagen; finalmente, se explicará el papel que los realities cumplen en el marco de la economía estética contemporánea y se ofrecerá una explicación sociopsicológica de su poder de seducción. El artículo en su conjunto aborda el estudio del reality a través del lente amplio de una crítica de la industria del entretenimiento. Abstract in english Reality shows are one of the most successful television genres in the last few years. The exploration that this article will make around this genre consists of three parts. First, the tension that realities cause between representation as a traditional aesthetic style and simulation as an emergent a [...] esthetic style will be examined. Second, the way realities participate in the construction of the world as image will be described. Finally, the article will explain the role that realities play in the contemporary aesthetic economy, and offer a socio-psychological explanation of its seductive power. The article approaches the study of reality shows by taking a critical perspective to the entertainment industry.

  14. La Realidad Simulada. Una Crítica del reality show The simmulation of Reality. A critic of the reality show.

    Directory of Open Access Journals (Sweden)

    Leonardo Ordóñez Díaz

    Full Text Available El reality show es el formato televisivo más exitoso de los últimos años. Este artículo efectúa una exploración en torno a dicho formato articulada en tres partes. Primero, se estudiará la tensión que los realities generan entre la representación como esquema estético tradicional y la simulación como esquema estético emergente; luego, se detallará la manera en que los realities participan en la producción del mundo como imagen; finalmente, se explicará el papel que los realities cumplen en el marco de la economía estética contemporánea y se ofrecerá una explicación sociopsicológica de su poder de seducción. El artículo en su conjunto aborda el estudio del reality a través del lente amplio de una crítica de la industria del entretenimiento.Reality shows are one of the most successful television genres in the last few years. The exploration that this article will make around this genre consists of three parts. First, the tension that realities cause between representation as a traditional aesthetic style and simulation as an emergent aesthetic style will be examined. Second, the way realities participate in the construction of the world as image will be described. Finally, the article will explain the role that realities play in the contemporary aesthetic economy, and offer a socio-psychological explanation of its seductive power. The article approaches the study of reality shows by taking a critical perspective to the entertainment industry.

  15. Small lakes show muted climate change signal in deepwater temperatures

    Science.gov (United States)

    Winslow, Luke A.; Read, Jordan S.; Hansen, Gretchen J. A.; Hanson, Paul C.

    2015-01-01

    temperature observations were collected from 142 lakes across Wisconsin, USA, to examine variation in temperature of lakes exposed to similar regional climate. Whole lake water temperatures increased across the state from 1990 to 2012, with an average trend of 0.042°C yr-1 ± 0.01°C yr-1. In large (>0.5 km2) lakes, the positive temperature trend was similar across all depths. In small lakes (0.5 times the maximum lake depth. The differing response of small versus large lakes is potentially a result of wind-sheltering reducing turbulent mixing magnitude in small lakes. These results demonstrate that small lakes respond differently to climate change than large lakes, suggesting that current predictions of impacts to lakes from climate change may require modification.

  16. Small lakes show muted climate change signal in deepwater temperatures

    Science.gov (United States)

    Winslow, Luke A.; Read, Jordan S.; Hansen, Gretchen J. A.; Hanson, Paul C.

    2015-01-01

    Water temperature observations were collected from 142 lakes across Wisconsin, USA, to examine variation in temperature of lakes exposed to similar regional climate. Whole lake water temperatures increased across the state from 1990 to 2012, with an average trend of 0.042°C?yr?1?±?0.01°C?yr?1. In large (>0.5?km2) lakes, the positive temperature trend was similar across all depths. In small lakes (0.5 times the maximum lake depth. The differing response of small versus large lakes is potentially a result of wind-sheltering reducing turbulent mixing magnitude in small lakes. These results demonstrate that small lakes respond differently to climate change than large lakes, suggesting that current predictions of impacts to lakes from climate change may require modification.

  17. Simple Blunt Trauma and Diaphragmatic Rupture Showing Delayed Clinical Signs

    Directory of Open Access Journals (Sweden)

    Tar?k Ocak

    2012-01-01

    Full Text Available The diaphragm provides the progression between certain structures and the chest cavity by means of an anatomic hiatus. The diaphragm is the second most functional muscle structure of the body after the heart. Diaphragm injuries may result from serious blunt or penetrating injuries. While most of the blunt diaphragm infuries are caused by traffic accidents and falls from heights, some may occur as a result of other blunt traumas to the lower chest or epigastrium. Diaphragm injuries may be seen in t 0.8-1.6% of the patients hospitalized due to blunt abdominal trauma. In this study, we will report that a diaphagm injury of a patient who has a history of blunt abdominal trauma was diagnosed six months after the trauma when he was admitted to hospital because of stomach ache and pain in his left chest.

  18. How to Statistically Show the Absence of an Effect

    OpenAIRE

    Etienne Quertemont

    2011-01-01

    In experimental studies, the lack of statistical significance is often interpreted as the absence of an effect. Unfortunately, such a conclusion is often a serious misinterpretation. Indeed, non-significant results are just as often the consequence of an insufficient statistical power. In order to conclude beyond reasonable doubt that there is no meaningful effect at the population level, it is necessary to use proper statistical techniques. The present article reviews three different approac...

  19. The staff show their profound attachment to SLS

    CERN Multimedia

    Association du personnel

    2007-01-01

    The results of the poll on the Saved Leave Scheme (SLS) have now been analyzed and are published in this edition and on our web site. You were 1194 to reply to the questionnaire (approximately 50% of all staff members). The distribution of the replies according to certain variables (sex, age, career path, etc.) in the sample corresponds to the one observed for the overall staff population. This indicates that the sample is representative.

  20. Cell-based immune therapy shows promise in leukemia patients

    Science.gov (United States)

    Memorial Sloan-Kettering investigators report that genetically modified immune cells have shown great promise in killing the cancer cells of patients with relapsed B cell acute lymphoblastic leukemia (ALL). In fact, all five of the patients who have received the new therapy – known as targeted immunotherapy – have gone into complete remission, with no detectable cancer cells. The results of this ongoing clinical trial are reported online on March 20 in the journal Science Translational Medicine.

  1. Distinct iPS Cells Show Different Cardiac Differentiation Efficiency

    OpenAIRE

    Yohei Ohno; Shinsuke Yuasa; Toru Egashira; Tomohisa Seki; Hisayuki Hashimoto; Shugo Tohyama; Yuki Saito; Akira Kunitomi; Kenichiro Shimoji; Takeshi Onizuka; Toshimi Kageyama; Kojiro Yae; Tomofumi Tanaka; Ruri Kaneda; Fumiyuki Hattori

    2013-01-01

    Patient-specific induced pluripotent stem (iPS) cells can be generated by introducing transcription factors that are highly expressed in embryonic stem (ES) cells into somatic cells. This opens up new possibilities for cell transplantation-based regenerative medicine by overcoming the ethical issues and immunological problems associated with ES cells. Despite the development of various methods for the generation of iPS cells that have resulted in increased efficiency, safety, and general vers...

  2. US data show sharply rising drug?induced death rates

    OpenAIRE

    Paulozzi, Leonard J; Annest, Joseph L

    2007-01-01

    Substantial numbers of deaths are related to disease and injury resulting from the use of drugs, alcohol and firearms worldwide. Death rates associated with these exposures were compared with those from motor vehicle crashes in the US from 1979 to 2003 by race. Among Caucasians, drug?induced death rates rose sharply after 1990 and surpassed deaths involving alcohol and firearms in 2001 and 2002, respectively. Among African?Americans, drug?induced deaths surpassed alcohol?induced deaths for th...

  3. Young children show the bystander effect in helping situations.

    Science.gov (United States)

    Plötner, Maria; Over, Harriet; Carpenter, Malinda; Tomasello, Michael

    2015-04-01

    Much research in social psychology has shown that otherwise helpful people often fail to help when bystanders are present. Research in developmental psychology has shown that even very young children help and that the presence of others can actually increase helping in some cases. In the current study, in contrast, 5-year-old children helped an experimenter at very high levels when they were alone but helped significantly less often in the presence of bystanders who were potentially available to help. In another condition designed to elucidate the mechanism underlying the effect, children's helping was not reduced when bystanders were present but confined behind a barrier and thus unable to help (a condition that has not been run in previous studies with adults). Young children thus show the bystander effect, and it is due not to social referencing or shyness to act in front of others but, rather, to a sense of a diffusion of responsibility. PMID:25792132

  4. Synthetic analogs of anoplin show improved antimicrobial activities

    DEFF Research Database (Denmark)

    Munk, Jens Kristian; UggerhØj, Lars Erik

    2013-01-01

    We present the antimicrobial and hemolytic activities of the decapeptide anoplin and 19 analogs thereof tested against methicillin-resistant Staphylococcus aureus ATCC 33591 (MRSA), Escherichia coli (ATCC 25922), Pseudomonas aeruginosa (ATCC 27853), vancomycin-resistant Enterococcus faecium (ATCC 700221) (VRE), and Candida albicans (ATCC 200955). The anoplin analogs contain substitutions in amino acid positions 2, 3, 5, 6, 8, 9, and 10. We use these peptides to study the effect of altering the charge and hydrophobicity of anoplin on activity against red blood cells and microorganisms. We find that increasing the charge and/or hydrophobicity improves antimicrobial activity and increases hemolytic activity. For each strain tested, we identify at least six anoplin analogs with an improved therapeutic index compared with anoplin, the only exception being Enterococcus faecium, against which only few compounds are more specific than anoplin. Both 2Nal(6) and Cha(6) show improved therapeutic index against all strains tested.

  5. USC researchers show increase of cell mutations with age

    Science.gov (United States)

    Research at the Keck School of Medicine of USC (home of the USC Norris Comprehensive Cancer Center) showed evidence that cell mutations increase with age, causing supposedly identical cells to diverge genetically. The report is featured as the cover article in the April issue of the journal Aging Cell. The lining of the colon is made up of crypts, sections composed of about 2,000 cell clones. The researchers were able to analyze and compare the genome of crypts from different areas of the same person’s colon. In the colon, genetic mutations are implicated in cancer, and the mutations increase in cases of severe inflammatory bowel disease. Cell divergence in other parts of the body may play a role in other diseases as well.

  6. Does ELF chorus show evidence of power line stimulation

    International Nuclear Information System (INIS)

    It has previously been reported that electromagnetic chorus exhibits a longitudinal dependence, with enhanced occurrence over population centers (Alaska-New Zealand, Eastern U.S.-Canada, Western Europe and Western Siberia). This result has been cited as possible evidence of Power Line Harmonic Radiation (PLR) control of magnetospheric chorus. In this paper the authors report an analogous study using chorus data from OGO-5 to test this result. Chorus is found to exhibit maxima over the Eastern USSR, Greenland and Central Siberia and minima over central and Eastern Canada, a distribution significantly different than the OGO-3 result. This gross discrepancy is explained as an effect of data oversampling (presistence) in the method of analysis used in the previous study. The OGO-5 data are reanalysed with the oversampling removed. It is found that none of the longitudinal maxima or minima are then statistically significant (<2sigma). Thus, they find no statistically significant correlation between longitude and chorus occurrence which implies that there is little or no evidence of PLR effects on chorus triggering. (Auth.)

  7. Sediment score shows mountain off beat with climate change

    Science.gov (United States)

    Gourlan, Alexandra T.; Voisin, Christophe; Chauvel, Catherine; Braun, Jean

    2013-04-01

    Neodymium (Nd) isotopes recorded in marine sediments are usually used in paleoceanography as tracers of changes of past climate. The Indian Ocean raises the interest because of its connections with the Atlantic and the Pacific Oceans, and because of the proximity of the Himalayans drained by the Ganga-Brahmaputra-Meghna (GBM) rivers system. The origin of the variations of seawater Nd isotopic data observed over the last Glacial/Interglacial cycles remains unclear. They are either interpreted as changes in the global oceanic circulation or as changes in the continental input of Nd related to changes in the continental rainfalls. Here we present a simple technique to discriminate these two interpretations at a given site, based on the correlation of ?18O and ?Nd seawater signals. We show in-phase records at site SK129-CR2 (Arabian Sea) and out-of phase records at site ODP-758 (Bay of Bengal), suggesting that the two sites have recorded different phenomena through time. Arabian Site fluctuations were interpreted as changes of the thermohaline circulation and Bay of Bengal Site fluctuations as changes on the Himalayan input. As Himalayan rivers input is linked to the Earth's climate variability, we filtered the time series of ?18O and ?Nd at Site ODP 758 around the three periods related to the three main orbital parameters. We show that the time lag between ?18O and ?Nd increases from 1000 to 2000 and then to 7000 years for the 23 ky, 41 ky, and 100 ky filtered signals. To explain the delays between temperature changes recorded by ?18O and ?Nd, two models were proposed: diffusive and erosion models of Himalayans. For the first time, we demonstrate that a geochemical dataset can record and thus constrain the time lag in the erosional response of an active mountain belt to climate change.

  8. Low temperature impact toughness of the main gas pipeline steel after long-term degradation

    Science.gov (United States)

    Maruschak, Pavlo; Danyliuk, Iryna; Bishchak, Roman; Vuherer, Tomaž

    2014-12-01

    The correlation of microstructure, temperature and Charpy V-notch impact properties of a steel 17G1S pipeline steel was investigated in this study. Within the concept of physical mesomechanics, the dynamic failure of specimens is represented as a successive process of the loss of shear stability, which takes place at different structural/scale levels of the material. Characteristic stages are analyzed for various modes of failure, moreover, typical levels of loading and oscillation periods, etc. are determined. Relations between low temperature derived through this test, microstructures and Charpy (V-notch) toughness test results are also discussed in this paper.

  9. Surface-Supported Hydrocarbon ? Radicals Show Kondo Behavior.

    Science.gov (United States)

    Müllegger, Stefan; Rashidi, Mohammad; Fattinger, Michael; Koch, Reinhold

    2013-03-21

    Stable hydrocarbon radicals are utilized as spin standards and prototype metal-free molecular magnets able to withstand ambient conditions. Our study presents experimental results obtained with submolecular resolution by scanning tunneling microscopy and spectroscopy from monomers and dimers of stable hydrocarbon ? radicals adsorbed on the Au(111) surface at 7-50 K. We provide conclusive evidence of the preservation of the radical spin-1/2 state, aiming to establish ?,?-bisdiphenylene-?-phenylallyl (BDPA) on Au(111) as a novel Kondo system, where the impurity spin is localized in a metal-free ? molecular orbital of a neutral radical state in gas phase preserved on a metal support. PMID:23539333

  10. Concept or show of strength; Konzept oder Kraftakt?

    Energy Technology Data Exchange (ETDEWEB)

    Weber, Tilman

    2013-04-15

    The hybrid drive is a compact transmission concept which combines the electrical and mechanical engineering of a wind power plant. The generator and gearbox sit tight in place so that the gearbox as well as its support structure and housing structure are shorter. This far-reaching reform aims to design wind turbines in the power class three megawatts and more. The company Winergy (Voerde, Federal Republic of Germany) developed a medium-fast rotating compact gear that has been tested in September 2012 under full load. Result: a 35 percent shorter power train, a 10 percent reduction in weight and a system efficiency of 96.5 percent.

  11. Glioma-associated endothelial cells show evidence of replicative senescence

    International Nuclear Information System (INIS)

    The innately programmed process of replicative senescence has been studied extensively with respect to cancer, but primarily from the perspective of tumor cells overcoming this stringent innate barrier and acquiring the capacity for unlimited proliferation. In this study, we focus on the potential role of replicative senescence affecting the non-transformed endothelial cells of the blood vessels within the tumor microenvironment. Based on the well-documented aberrant structural and functional features of blood vessels within solid tumors, we hypothesized that tumor-derived factors may lead to premature replicative senescence in tumor-associated brain endothelial cells (TuBEC). We show here that glioma tissue, but not normal brain tissue, contains cells that express the signature of replicative senescence, senescence-associated ?-galactosidase (SA-?-gal), on CD31-positive endothelial cells. Primary cultures of human TuBEC stain for SA-?-gal and exhibit characteristics of replicative senescence, including increased levels of the cell cycle inhibitors p21 and p27, increased resistance to cytotoxic drugs, increased growth factor production, and inability to proliferate. These data provide the first demonstration that tumor-derived brain endothelial cells may have reached an end-stage of differentiation known as replicative senescence and underscore the need for anti-angiogenic therapies to target this unique tumor-associated endothelial cell populationhelial cell population

  12. Chinese dyslexics show neural differences in morphological processing.

    Science.gov (United States)

    Liu, Li; Tao, Ran; Wang, Wenjing; You, Wenping; Peng, Danling; Booth, James R

    2013-10-01

    Previous behavioral studies have suggested that morphological awareness is impaired in Chinese children with reading disability (RD), but how this is reflected in brain alterations is not known. Using functional magnetic resonance imaging (fMRI), the current study compared morphological processing in a RD group (11-13 years old) to an age-matched typically developing (TD) group. Participants made semantic relatedness judgments to incongruent word pairs that were either semantically related but did not share a morpheme or semantically unrelated but did share a morpheme. This was compared to conditions where semantic relatedness and morphemic information was congruent. A smaller incongruency effect was found in left dorsal posterior (BA9) and ventral anterior (BA47) inferior frontal gyrus (IFG) in the RD compared to the TD, suggesting that the RD is less sensitive to morphological information. This was a specific deficit as a phonological control task that manipulated congruency between orthography and phonology did not show group differences in the IFG. Moreover, brain activation in the IFG for the incongruency effect in the semantic task was negatively correlated with reading skill for the RD group only, suggesting that higher skill children with RD may rely on a compensatory whole-word strategy by ignoring the morphemic information. PMID:23872198

  13. WSSV-induced crayfish Dscam shows durable immune behavior.

    Science.gov (United States)

    Ng, Tze Hann; Hung, Hsin-Yi; Chiang, Yi-An; Lin, Jia-Hung; Chen, Yi-Ning; Chuang, Ya-Chu; Wang, Han-Ching

    2014-09-01

    One of the major gaps in our understanding of arthropod specific immune priming concerns the mechanism[s] by which the observed long-term (>2 weeks) protective effects might be mediated. Hypervariable Dscam (Down syndrome cell adhesion molecule) might support arthropod innate immunity with specificity for more extended periods. We show here that, in the relatively long-lived arthropod Cherax quadricarinatus, CqDscam does not behave like a typical, immediately-acting, short-lived innate immune factor: CqDscam was not induced within hours after challenge with a lethal virus, but instead was only up-regulated after 2-5 days. This initial response faded within ? 2 weeks, but another maximum was reached ? 1 month later. At around 2 months after the initial challenge, the virus-induced CqDscam bound to the virus virion and acted to neutralize the virus However, although CqDscam helped crayfish to survive during persistent infection, it nevertheless failed to provide any enhanced protection against a subsequent WSSV challenge. Thus, CqDscam is capable of supporting extended anti-virus immune memory in arthropods. Also, during a persistent virus infection, the balance of "immune firepower" in crayfish appears to be altered such that the general immune factors become depleted while CqDscam becomes relatively predominant. PMID:24973514

  14. Show: Dr. H, the life and death of pancakes

    CERN Multimedia

    2012-01-01

    Dr. H, the life and death of pancakes, a comic theatrical creation, written and performed by Heiko Buchholz.   Monday 2 April 2012 in German Tuesday 3 April 2012 in English Wednesday 4 April 2012 in French 8:30 p.m. at the Globe of Science and Innovation. This production takes a comic look at scientific methods, as applied to a common object: the pancake. More specifically, Dr H. regales his audience with statistics, experiments and scientific data surrounding this egg-and-milk-based culinary delight. And although these zany sketches are nothing short of absurd, the audience is drawn in more often than you might expect… and taken on quite an unexpected journey into the behavioural disorders, personality quirks and psychoanalysis of the base pancake. This show playfully mocks scientific logic and discourse, forcing the audience to reflect on their gullibility in the face of science and its impenetrable jargon. It purports to be neither explanation nor illustration of scientific fact,...

  15. Film showing - Higgs: into the heart of imagination

    CERN Document Server

    CERN Bulletin

    2010-01-01

    On 29 April at 7pm Dutch filmmakers, Hannie van den Bergh and Jan van den Berg, will introduce their directorial debut, Higgs: into the heart of imagination in CERN’s Main Auditorium.   This documentary is about the curiousity, passion and imaginative powers of science. Featuring physicists working at CERN, in particular in ATLAS, and filmed over four years, the film-makers have created a cinematic journey into the heart of imagination. They follow Stan Bentvelsen, head of the Dutch research group at CERN, and watch as he prepares his team for the start of the LHC, as well as the scientific competition to find the elusive Higgs particle. The film also features Peter Higgs as he discusses his work from 1964. The directors have created theatre productions and other multimedia projects under the title The Imagination of Invisible Dimensions, which allow for adventurous dialogues between art and science. All are welcome to attend this showing and afterwards there will be a short question...

  16. Periostin shows increased evolutionary plasticity in its alternatively spliced region

    Directory of Open Access Journals (Sweden)

    Hoersch Sebastian

    2010-01-01

    Full Text Available Abstract Background Periostin (POSTN is a secreted extracellular matrix protein of poorly defined function that has been related to bone and heart development as well as to cancer. In human and mouse, it is known to undergo alternative splicing in its C-terminal region, which is devoid of known protein domains. Differential expression of periostin, sometimes of specific splicing isoforms, is observed in a broad range of human cancers, including breast, pancreatic, and colon cancer. Here, we combine genomic and transcriptomic sequence data from vertebrate organisms to study the evolution of periostin and particularly of its C-terminal region. Results We found that the C-terminal part of periostin is markedly more variable among vertebrates than the rest of periostin in terms of exon count, length, and splicing pattern, which we interpret as a consequence of neofunctionalization after the split between periostin and its paralog transforming growth factor, beta-induced (TGFBI. We also defined periostin's sequential 13-amino acid repeat units - well conserved in teleost fish, but more obscure in higher vertebrates - whose secondary structure is predicted to be consecutive beta strands. We suggest that these beta strands may mediate binding interactions with other proteins through an extended beta-zipper in a manner similar to the way repeat units in bacterial cell wall proteins have been reported to bind human fibronectin. Conclusions Our results, obtained with the help of the increasingly large collection of complete vertebrate genomes, document the evolutionary plasticity of periostin's C-terminal region, and for the first time suggest a basis for its functional role.

  17. A case of osseous scintigraphy showing focuses of multifocal tuberculosis

    International Nuclear Information System (INIS)

    Incidence of tuberculosis in developed countries presents in the last years a spectacular boost. However, the osteo-articular system is afflicted by tuberculosis only in a few percent of cases and the multifocal character represents less than 5% of osseous tuberculosis. It is presented here a case of multifocal osseous tuberculosis only to stress its rarity. A woman 28 years old from Djibouti presents since 8 months an asthenia and dorsal pains long thought as psychalgia. The examination has shown a major vertebral stiffness and limitation of right haunch. The radiographs showed a scoliosis centered on D8 with modifications. The biologic data are VS = 90, CRP = 124 and the hemogram is normal. The intradermal reaction (10 U of tuberculin) is phlyctenular. The TDM indicates lytic vertebral extension on D7 - D8, the osseous scintigraphy with MDP - 99 mTc indicates no anomaly in the vascular arrival time; a few minutes after injection: dorsal and upper and of right femur hyperactivity; 2 h after injection: hyper-fixation of D7 to D9 and of the upper end of right femur. The IRM indicates para-vertebral abscess of D7 to D9 with epidural abscess; abscess in the upper part of the loge of right adductors with osseous affliction of the femur's upper end; a bacillary infectious process was a priori evoked. The patient was then placed under quadruple antibiotic-therapy anti-tuberculous care. In case of anomalous multifocal osseous scintigraphy the tuberculous affliction is part oraphy the tuberculous affliction is part of the differential diagnosis, particularly in the immigrant populations or in HIV+ persons

  18. "The show must go on!" Beserings van dramastudente tydens opleiding

    Directory of Open Access Journals (Sweden)

    J Deacon

    2009-03-01

    Full Text Available "THE SHOW MUST GO ON!" LIABILITY WHEN IT COMES TO DRAMA STUDENTS WHEN INJURED WHILE IN TRAININGThis article emphasises the uncertainty in the relationship between a student undergoing practical training and his/her lecturer or university, if the student should be injured and wants to claim compensation. One must first establish whether the student can be described as an employee of the lecturer or university, or as a vocational worker or independent contractor. Once the status of the student has been established, the relevant legislation can be determined, whether it is the Labour Relations Act or the Basic Conditions of Employment. It is, however, not that simple and a person in the capacity of a student does not accord with the definition of an employee or an independent contractor or a vocational worker. One will have to rely on the assumption in section 83A in the Basic Conditions of Employment that a student is an employee when he does practical training for the benefit of the university. The Occupational Health and Safety Act requires employers to assure that the workplace is a safe environment for employees, with the minimum risks involved. The Compensation for Occupational Injuries and Diseases Act makes it possible for an employee to claim compensation when such a risk becomes a reality.This article also tries to compare the situation of a student sports person injured while participating in university sports, and a drama student injured during a performance or rehearsal of a play. It is stated that the relationship between the drama student and lecturer is similar to the relationship between a sports person and his/her coach, but the relationship differs in that a sports person’s risk of getting hurt is much greater than that of a drama student, The contracts between sports players and their authorities are also stipulated in much more detail than the contracts (if any between the drama students and the university. It is concluded that the legislation is not clear on the specific matters where a student undergoes practical training while they are still studying. The suggestion is that a sectoral determination must be put in place to regulate the relationship, the remuneration, the working hours and the working conditions and risks involved.The article is in Afrikaans.

  19. Dizer-mostrar o estranho / Saying-showing strangeness

    Scientific Electronic Library Online (English)

    Helena, Martins.

    2012-06-01

    Full Text Available Este trabalho explora a vitalidade contemporânea de duas enfáticas vozes do século XX: Ludwig Wittgenstein e Samuel Beckett. Consideram-se em especial as seguintes divisas: de Wittgenstein, nada está oculto (Investigações, § 435); de Beckett, nada a expressar (Três diálogos com George Duthuit, I). O [...] dito de Wittgenstein é muitas vezes tomado como marca de renúncia à distinção, por ele antes sustentada, entre aquilo que se pode dizer e aquilo que apenas se mostra (Tractatus, Prefácio, 6.522). O dito de Beckett é, por sua vez, frequentemente visto como indício de uma visão cética da linguagem, que a condena a uma espécie de maldição da autorreferência. Tais formas de ler tendem a se ligar às percepções, bastante disseminadas, de que Wittgenstein escreve o comum (o "ordinário"); e Beckett, o absurdo. Questiono aspectos dessas duas produtivas leituras, sustentando que, de forma a meu ver um pouco debilitante, elas tendem a ignorar, ou talvez a apaziguar, um estranho que insiste em se dizer-mostrar na prosa poética dos dois autores. Abstract in english This paper explores the contemporary strength of two of last century's most emphatic voices: Ludwig Wittgenstein and Samuel Beckett. The following mottos are brought together with special attention: nothing is hidden, by Wittgenstein (Philosophical Investigations, §435); and nothing to express, by B [...] eckett (Three dialogues with Georges Duthuit, I). Wittgenstein's saying is frequently taken as indication that he renounces his earlier distinction between what can be said and what can only be shown (Tractatus, Preface, 6.522). Beckett's saying is, in turn, often seen as evidence of a skeptical take on language, whereas it is, so to speak, doomed to self-reference. These interpretations tend to be linked to the widespread perceptions that Wittgenstein writes the ordinary, whereas Beckett writes the absurd. I question some aspects of these two productive readings, arguing that, in a somewhat debilitating manner, they tend to ignore, or perhaps pacify, a strangeness that insists in saying-showing itself in the poetic prose of both authors.

  20. Anger, Cognition, Ideology: What Crash Can Show Us About Emotion

    Directory of Open Access Journals (Sweden)

    Sue J. Kim

    2010-06-01

    Full Text Available

    Abstract (E: Sue J. Kim’s essay “Anger, Cognition, Ideology: What Crash Can Show Us About Emotion” argues for the relevance and importance of cognitive studies to ethnic and postcolonial literary studies, and vice versa. After surveying recent developments in the field of cognitive studies, the essay combines cultural and cognitive approaches in order to examine anger in and around the 2005 Paul Haggis film Crash.

     

    Abstract (F: Dans cet article, l’auteur fait un plaidoyer pour l’application des études cognitives aux études ethniques et postcoloniales et inversement. L’essai présente d’abord un survol des récents développements dans le domaine des études cognitives, puis combine les approches culturelles et cognitives dans une lecture détaillée du thème de la colère dans le film Crash de Paul Haggis (2005.

     

  1. Chromatin decondensed by acetylation shows an elevated radiation response

    International Nuclear Information System (INIS)

    V-79 Chinese hamster lung fibroblasts exposed to 5 mM n-sodium butyrate were irradiated with 60Co gamma rays and cell survival was determined by the cell colony assay. In a separate set of experiments the acetylated chromatin obtained from these cells was irradiated and the change of molecular weight of the DNA was evaluated by alkaline sucrose density centrifugation. At a survival level of 10(-2) to 10(-4) cells exposed to butyrate were found to be 1.3-1.4 times more radiosensitive than control cells. Exposure of isolated chromatin to 100 Gy of 60Co gamma irradiation generated 0.9 +/- 0.03 single-strand breaks (ssb) per 10 Gy per 10(8) Da and 2.0 +/- 0.3 ssb/10 Gy/10(8) Da for control and acetylated chromatin, respectively. The elevated radiation sensitivity of chromatin relaxed by acetylation is in good agreement with previous results on chromatin expanded by histone H1 depletion. Packing and accessibility of DNA in chromatin appear to be major factors which influence the radiation sensitivity. The intrinsic radiation sensitivity of chromatin in various packing states is discussed in light of the variation of radiation sensitivity of whole cells in the cell cycle which incorporates repair

  2. Unexpected show up of incomplete fusion at low projectile energies

    Directory of Open Access Journals (Sweden)

    Singh B.P.

    2011-10-01

    Full Text Available In this paper, some of the important ?ndings of recent measurements performed to study incomplete fusion at low bombarding energies (i.e., Elab ? 4-7 MeV/nucleon in 12C, 16O+169Tm systems are brie?y summarized. The spin-distributions of xn, pxn, ?xn/2?xn- channels have been measured to probe entirely different ?-emission patterns (and feeding intensity pro?les during the de-excitation of complete and incomplete fusion objects. Incomplete fusion strength function has been deduced (from the analysis of experimental excitation functions in context of equilibrated compound nucleus decay to achieve information of onset and strength of incomplete fusion in terms of various entrance channel parameters. Presence of incomplete fusion at slightly above barrier energies has been con?rmed by the measurement of linear momentum distribution of heavy recoils. Present results conclusively demonstrate, the existence of incomplete fusion at low bombarding energies, its strong dependence on entrance channel parameters, and the possibility to populate high spin states.

  3. Oklahoma Cherokee formation study shows benefits of gas tax credits

    International Nuclear Information System (INIS)

    To no one's surprise, the administration's recently released energy initiative package does not advocate the use of tax incentives such as the Internal Revenue Code Sec. 29 (tight sand gas) credit that expired Dec. 31, 1992. This is unfortunate since tax credits do stimulate drilling, as the authors' recent study of Oklahoma's Pennsylvanian age Cherokee formation demonstrates. Within this 783,000 acre study area, more than 130 additional wells were drilled between 1991--92 because of tax credit incentives. And such tax credits also increase total federal tax revenues by causing wells to be drilled that would not have been drilled or accelerating the drilling of wells, thereby increasing taxable revenue. In short, tax credits create a win-win situation: they stimulate commerce, increase tax revenues, reduce the outflow of capital to foreign petroleum projects, and add to the nation's natural gas reserve, which is beneficial for national security, balance of payments, the environment, and gas market development. The paper discusses the study assumptions, study results, and the tax credit policy

  4. Asia-Pacific area shows big gains in processing

    International Nuclear Information System (INIS)

    This paper reports on the Asia-Pacific region's buoyant refining and petrochemical industries that are reacting to lessons from the Persian gulf war. First-and least palatable-is the knowledge there is no alternative to oil from the Middle East to fuel headlong economic growth. Iraq's Aug. 2, 1990, invasion of Kuwait, resulting in the loss of crude oil from both countries and the flow of products from Kuwait's sophisticated refining complexes, hammered home another valuable lesson. In a crisis, the petroleum industry-oil exporting countries in particular-will in the short term find it easier to make substitute crude supplies available than to conjure up products from alternative processing capacity. The Japanese, as might be expected, are implementing new policies to take account of this lesson. Japan's tightly controlled refining sector has been told it can expand capacity for the first time in 18 years. And, with the blessing of the Japanese government, a group of companies led by Nippon Oil has agreed to a joint venture with Saudi Arabian Oil Co. that will lead to new refining capacity in Japan and a new export refinery in Saudi Arabia that is likely to be dedicated to the Japanese market

  5. Ephemeral metapopulations show high genetic diversity at regional scales.

    Science.gov (United States)

    Berendonk, T U; Spitze, K; Kerfoot, W C

    2009-10-01

    One of the primary questions concerning the long-term preservation of nature and its diversity is the maintenance of genetic diversity. However, despite numerous theoretical investigations, comparative empirical information on how local extinctions influence regional genetic variation does not exist. To our knowledge, this is the first report of an empirical study comparing the genetic variation of permanent vs. ephemeral species at two scales (local variation, regional variation). This approach, utilizing a microsatellite analysis of six midge species of the genus Chaoborus generated intriguing scale-dependent results. Species that experienced repeated local extinctions had reduced genetic variation at the local level, yet the regional genetic variation was greater than in species with permanent populations. Our findings call into question the assumption that species with repeated local extinctions generally contain lower genetic diversity, especially if they experience a "nomadic" pattern of dispersal. We encourage comparative analyses of empirical genetic data at dual scales as molecular tools become more available in ecological studies. PMID:19886476

  6. OGJ group earnings show big gain for 1993

    International Nuclear Information System (INIS)

    Earnings for Oil and Gas Journal's group of 22 large US oil companies advanced sharply last year, increasing 70.9% from 1992. Group profits totaled $16.1 billion, with the gain stemming largely from lack of one time charges that depressed earnings in 1992. Adoption of new accounting rules associated with future postretirement costs caused the 1992 charges. US exploration and production earnings were mixed, tied in part to oil and gas production volumes. Higher gas prices and production helped boost earnings for a number of companies. But the earnings improvement from gas was offset by reduced oil production and prices. Results from non-U.S. E and P also were mixed. Average worldwide crude oil export prices were down from year earlier levels. However, for some companies this was offset by higher production levels and lower exploration costs. Earnings from refining and marketing were improved from 1992 levels, particularly for non-US operations. Lower feedstock costs, especially in the fourth quarter, helped boost earnings in this sector. Refining earnings gains also flowed from lower costs due to restructuring and an accompanying improvement in operating efficiency. The paper discusses world trends, operations and prices, US exploration and production, non-US E and P, US and non-US refining and marketing, petrochemicals, and the forecast for future demand

  7. 1998 results

    International Nuclear Information System (INIS)

    This document presents the financial and commercial results of Gaz de France (GdF) company for 1998. The following points are presented successively: financial results (budget results, turnover, self-financing capacity, investments, debt situation), commercial results (some remarkable numbers and records, the tertiary and residential market, the industrial market, cogeneration and natural gas for vehicles), the strategy, 1998 realizations and perspectives (the natural gas energy in the 21. century, the development of GdF, the gas distribution and services (development of the French distribution system, export of the know-how, development of services), the transportation and storage systems threw Europe (densification of the pipeline network, the key-position of France, the north-south equilibrium of the distribution network), the natural gas production by GdF, the diversification of supplies, and the main daughter companies abroad). (J.S.)

  8. Global Uranium Supply Ensured for Long Term, New Report Shows

    International Nuclear Information System (INIS)

    Full text: Uranium resources and production are on the rise with the security of uranium supply ensured for the long term, according to a new report by the OECD Nuclear Energy Agency (NEA) and the International Atomic Energy Agency (IAEA). Uranium 2011: Resources, Production and Demand, commonly referred to as the ''Red Book'', shows that total identified uranium resources have grown 12.5% since 2008. However, the costs of production have also increased, leading to reductions in lower cost category resources. These figures, which reflect the situation as of 1 January 2011, mean that total identified resources are sufficient for over 100 years of supply based on current requirements. Global uranium mine production increased by over 25% between 2008 and 2010 because of significantly increased production in Kazakhstan, currently the world's leading producer. The increased resource base has been achieved thanks to a 22% increase in uranium exploration and mine development expenditures between 2008 and 2010, which in 2010 totalled over $2 billion. Demand for uranium is expected to continue to rise for the foreseeable future. Although the Fukushima Daiichi nuclear accident has affected nuclear power projects and policies in some countries, nuclear power remains a key part of the global energy mix. Several governments have plans for new nuclear power plant construction, with the strongest expansion expected in China, India, the Republic of Korea and the Russian Federation. The speed and magnitude of growth in generating capacity elsewhere is still to be determined. By the year 2035, according to the joint NEA-IAEA Secretariat, world nuclear electricity generating capacity is projected to grow from 375 GWe net (at the end of 2010) to between 540 GWe net in the low demand case and 746 GWe net in the high demand case, increases of 44% and 99% respectively. Accordingly, world annual reactor-related uranium requirements are projected to rise from 63 875 tonnes of uranium metal (tU) at the end of 2010 to between 98 000 tU and 136 000 tU by 2035. The currently defined uranium resource base is more than adequate to meet high-case requirements through 2035 and well into the foreseeable future. Although ample resources are available, meeting projected demand will require timely investments in uranium production facilities. This is because of the long lead times (typically in the order of ten years or more in most producing countries) required to develop production facilities that can turn resources into refined uranium ready for nuclear fuel production. With uranium production ready to expand to new countries, efforts are being made to develop transparent and well-regulated operations similar to those used elsewhere to minimise potential environmental and local health impacts. Although not the primary focus of the Red Book, activity updates on the environmental aspects of the uranium production cycle are included in the national reports in this edition. While the status of supply and demand is considered from the perspective of technologies in use today, the deployment of advanced reactors and fuel cycle technologies can also positively affect the long-term availability of uranium, conceivably extending the time horizon of the currently defined resource base to thousands of years. These are some of the findings in the just-published Uranium 2011: Resources, Production and Demand, a joint study by the OECD/NEA and the IAEA, carried out in co-operation with their member countries. This is the 24th edition of this periodic assessment (currently every two years) which has been published since the mid-1960s. (IAEA)

  9. Research Results

    Science.gov (United States)

    2011-12-01

    Research on Global Carbon Emission and Sequestration NSFC Funded Project Made Significant Progress in Quantum Dynamics Functional Human Blood Protein Obtained from Rice How Giant Pandas Thrive on a Bamboo Diet New Evidence of Interpersonal Violence from 129,000 Years Ago Found in China Aptamer-Mediated Efficient Capture and Release of T Lymphocytes on Nanostructured Surfaces BGI Study Results on Resequencing 50 Accessions of Rice Cast New Light on Molecular Breeding BGI Reports Study Results on Frequent Mutation of Genes Encoding UMPP Components in Kidney Cancer Research on Habitat Shift Promoting Species Diversification

  10. Survey on New Perkins Loan Proposal: NASFAA Survey Results Show Most Schools Oppose Proposed Perkins Loan Changes. Quick Scan Survey Results

    Science.gov (United States)

    National Association of Student Financial Aid Administrators (NJ1), 2009

    2009-01-01

    More than three-quarters of postsecondary institutions (79 percent) would prefer expanding the current Perkins Loan program rather than replacing it with the Direct Perkins Loan program being proposed in Congress, according to a recent survey of NASFAA-member schools. In fact, increasing unsubsidized Stafford Loan limits (80 percent) and lowering…

  11. The Influence of Heat Treatment on the Microstructure and Machinability of a Prehardened Mold Steel

    Science.gov (United States)

    Hoseiny, Hamed; Caballero, Francisca G.; M'Saoubi, Rachid; Högman, Berne; Weidow, Jonathan; Andrén, Hans-Olof

    2015-05-01

    The machinability performance of a modified AISI P20 steel, heat treated to have the same hardness but three different microstructures, lower bainite, tempered martensite, and primary spheroidized carbides in a tempered martensite matrix, was studied. The microstructures were characterized using light optical and scanning electron microscopy and X-ray diffraction, and mechanical properties were compared by means of tensile and Charpy V-notch impact tests. The influence of microstructure and the resultant mechanical properties on machinability was studied in the context of single tooth end milling operation. The results showed that the material containing primary spheroidized carbides exhibited a superior machinability at the expense of a marginal loss of tensile strength and impact toughness, with comparable yield strength to that of the material containing tempered martensite. By contrast, the material with bainitic microstructure showed the lowest yield strength and the poorest machinability performance while having the highest uniform elongation.

  12. Ganil results

    International Nuclear Information System (INIS)

    Recent Ganil results are presented: hot nuclei properties and multifragmentation, study of flow change around the inversion energy. Mesons and hard photons production are also briefly discussed. Correlations with studies that have been led in Saturne energy range, and the developments that can be foreseen in the future have been discussed

  13. Graphene Films Show Stable Cell Attachment and Biocompatibility with Electrogenic Primary Cardiac Cells

    OpenAIRE

    Kim, Taeyong; Kahng, Yung Ho; Lee, Takhee; Lee, Kwanghee; Kim, Do Han

    2013-01-01

    Graphene has attracted substantial attention due to its advantageous materialistic applicability. In the present study, we tested the biocompatibility of graphene films synthesized by chemical vapor deposition with electrogenic primary adult cardiac cells (cardiomyocytes) by measuring the cell properties such as cell attachment, survival, contractility and calcium transients. The results show that the graphene films showed stable cell attachment and excellent biocompatibility with the electro...

  14. Graphene Films Show Stable Cell Attachment and Biocompatibility with Electrogenic Primary Cardiac Cells

    Science.gov (United States)

    Kim, Taeyong; Kahng, Yung Ho; Lee, Takhee; Lee, Kwanghee; Kim, Do Han

    2013-01-01

    Graphene has attracted substantial attention due to its advantageous materialistic applicability. In the present study, we tested the biocompatibility of graphene films synthesized by chemical vapor deposition with electrogenic primary adult cardiac cells (cardiomyocytes) by measuring the cell properties such as cell attachment, survival, contractility and calcium transients. The results show that the graphene films showed stable cell attachment and excellent biocompatibility with the electrogenic cardiomyocytes, suggesting their useful applications for future cell biology studies. PMID:24292978

  15. Amanda results

    CERN Document Server

    Hill, G C

    2001-01-01

    The AMANDA (Antarctic Muon And Neutrino Detector Array) detector, located at the South Pole station, Antarctica, was recently expanded with the addition of six new strings, completing the phase referred to as AMANDA-II. This detector has been calibrated and in operation since January 2000. The first data analyses are currently underway. In this report we present an update on the results from the AMANDA-B10 detector, which operated during the austral winter 1997.

  16. Lead time for appointment and the no-show rate in an ophthalmology clinic

    Directory of Open Access Journals (Sweden)

    McMullen MJ

    2015-03-01

    Full Text Available Michael J McMullen, Peter A Netland Department of Ophthalmology, University of Virginia School of Medicine, Charlottesville, VA, USA Purpose: The purpose of this study was to determine if there is a correlation between the time in advance an appointment is scheduled and the no-show rate. Methods: This was a cross-sectional study conducted in an outpatient ophthalmology clinic. Appointment data were analyzed for 51,529 ophthalmology appointments in the computerized scheduling database during a 12-month period. Results: The average no-show rate was 21.7% and 6.6% for resident- and faculty-clinic, respectively (P<0.001. The no-show rate increased, and the likelihood an appointment would be kept decreased as the time in advance an appointment was scheduled increased. With a lead time for appointment of 0–2 weeks, the average no-show rate was 9.1% and 2.4% for the resident- and faculty-clinic, respectively. With a lead time for appointment of 6 months, the average no-show rate increased to 38.3% (P<0.001 and 6.9% (P<0.001 for the resident- and faculty-clinic, respectively. A predicted no-show rate model showed approximately 2% reduction of the no-show rate for 10% increase of the proportion of patients scheduled within 2 weeks, potentially reducing the no-show rate by nearly 60% with all appointments scheduled 0–2 weeks in advance. Conclusion: Clinic no-show rate increased as appointment lead time increased. Predictive models suggest that the implementation of a short-term appointment scheduling strategy may reduce the overall clinic no-show rate, particularly in clinic populations with a high no-show rate. Keywords: compliance, clinic scheduling, appointment time, appointment access, advance access, open access scheduling

  17. Correlation between radiation damage and magnetic properties in reactor vessel steels

    International Nuclear Information System (INIS)

    Since reactor pressure vessel steels are ferromagnetic, provide a convenient means to monitor changes in the mechanical properties of the material upon irradiation with high energy particles, by measuring their magnetic properties. Here, we discuss the correlation between mechanical and magnetic properties and microstructure, by studying the flux effect on the nuclear pressure vessel steel used in reactors currently under construction in Argentina. Charpy-V notched specimens of this steel were irradiated in the RA1 experimental reactor at 275 °C with two lead factors (LFs), 93 and 183. The magnetic properties were studied by means of DC magnetometry and ferromagnetic resonance. The results show that the coercive field and magnetic anisotropy spatial distribution are sensitive to the LF and can be explained by taking into account the evolution of the microstructure with this parameter. The saturation magnetization shows a dominant dependence on the accumulated damage. Consequently, the mentioned techniques are suitable to estimate the degradation of the reactor vessel steel

  18. Suffering by comparison: Twitter users' reactions to the Victoria's Secret Fashion Show.

    Science.gov (United States)

    Chrisler, Joan C; Fung, Kaitlin T; Lopez, Alexandra M; Gorman, Jennifer A

    2013-09-01

    Social comparison theory suggests that evaluating the self in comparison with others (e.g., peers, celebrities, models) can influence body image. Experimental studies that have tested effects of viewing idealized images in the media often show that women feel worse about themselves after seeing images that illustrate the beauty ideal. Twitter presents a naturally occurring opportunity to study viewers' reactions. An analysis was conducted of 977 tweets sent immediately before and during the 2011 Victoria's Secret Fashion Show that reference the show. Although the majority were idiosyncratic remarks, many tweets contain evidence of upward social comparisons to the fashion models. There were tweets about body image, eating disorders, weight, desires for food or alcohol, and thoughts about self-harm. The results support social comparison theory, and suggest that vulnerable viewers could experience negative affect, or even engage in harmful behaviors, during or after viewing the show or others like it. PMID:23769929

  19. BIOMETRICAL ANALYSIS OF ARABIAN FOALS AND THEIR LATER SUCCESSES IN SHOWS AND ON RACE TRACK

    Directory of Open Access Journals (Sweden)

    M. PIESZKA

    2013-12-01

    Full Text Available Arabian horses are one of the most important products of Polish horse breeding.Many of them are International and World champions in shows; others are very wellknown as courageous race horses. To obtain such champions it is necessary to takeunder consideration many factors affecting the final results. The objective of thisstudy was to evaluate the effect of biometrical measurements of the foals at birthaccording to their future successes in shows and on racetrack. The study was carriedout on 143 horses winning in shows and in races. Body weight, height at withers,girth and canon circumferences taken at birth of these horses were analysed.Additionally coat colour was studied. All studied animals were divided into threegroups according to each measurement and the differences between such groupswere evaluated according points obtained for particular place at shows and place inraces. It was stated that horses heavier at birth and with higher girth circumferencegot more successes both at shows and on racetrack. Horses with higher height atwithers at birth were more successful in shows while animals with higher canoncircumference won oftener at race track. It was observed that the most courageousrace horses were bay while most champions were grey.

  20. Prediction of Mechanical Properties of 25CrMo48V Seamless Tube Using Neural Network Model

    Science.gov (United States)

    Sun, Laibo; Zhang, Chuanyou; Wang, Qingfeng; Wang, Mingzhi; Yan, Zesheng

    In this investigation, a neural network model was established to predict mechanical properties of 25CrMo48V seamless tubes. The sensitivity analysis was also performed to estimate the relative significance of each chemical composition in mechanical behavior of steel tubes. The results of this investigation show that there is a good agreement between experimental and predicted values indicating desirable validity of the model. Among those alloying elements, the elements of carbon, silicon and chromium tended to play a more important role in controlling both the yielding strength and the Charpy-V-Notch transverse impact toughness. In comparison, the impurities such as O, N, S and P have a relatively weak impact. More detailed dependences of mechanical properties on each chemical composition in isolation can be revealed using the established model. The well-trained neural network has a great potential in designing tough and ultrahigh-strength seamless tubes and modeling the on-line production parameters.

  1. Paddy plants inoculated with PGPR show better growth physiology and nutrient content under saline condition

    Scientific Electronic Library Online (English)

    Yachana, Jha; R.B, Subramanian.

    2013-09-01

    Full Text Available The possible role of plant growth-promoting rhizobacteria (PGPR) to alleviate salt stress during plant growth has been studied on paddy rice (Oryza sativa L.) 'GJ-17' under greenhouse conditions; the study included growth parameters, mineral concentration, and antioxidant enzyme level. Salinity redu [...] ced plant growth, but PGPR inoculation reduced its harmful effect up to 1% salinity. Plants inoculated with PGPR under saline conditions showed 16% higher germination, 8% higher survival, 27% higher dry weight, and 31% higher plant height. Similarly, PGPR inoculated plants showed increased concentrations of N(26%), P (16%), K (31%), and reduced concentrations of Na (71%) and Ca (36%) as compared to non-inoculated control plants under saline conditions. Plants inoculated with PGPR under saline conditions also showed significant variations in antioxidant levels and growth physiology. Results suggested that inoculation with PGPR Bacillus pumilus and Pseudomonas pseudoalcaligenes in salt-stressed plants could help to alleviate salt stress in the paddy.

  2. Effects of coronary artery bypass surgery on regions showing persistent defects in thallium myocardial images

    International Nuclear Information System (INIS)

    The indications for revascularization surgery and its effects on myocardial regions showing persistent defects in thallium myocardial images are controversial. The effects of aortocoronary bypass surgery on myocardial perfusion and wall motion in the regions with persistent defects were evaluated in 47 patients with thallium-201 single photon emission computed tomography and left ventriculography. In areas showing persistent thallium defects preoperatively the rate of improvement of perfusion was only 24% by postoperative thallium imaging, and 57% by wall motion analysis. These results were significantly inferior to those of regions with transient defects, which were 84% and 82%, respectively. A persistent defect may not be a definitive marker of a non-viable scar, but the results of surgery on such regions were unsatisfactory. It is concluded, therefore, that revascuralization surgery in regions with persistent defects is not always recommended and that the indications for surgery should be individually determined with operative risk balanced against benefits. (author)

  3. Brain morphometry shows effects of long-term musical practice in middle-aged keyboard players

    Directory of Open Access Journals (Sweden)

    HannaGärtner

    2013-09-01

    Musicians showed a significantly better symmetric motor performance as well as a greater capability of controlling hand independence than controls. Structural MRI-data revealed significant volumetric differences between the brains of keyboard players, who practiced intensively and controls in right sensorimotor areas and the corticospinal tract as well as in the entorhinal cortex and the left superior parietal lobule. Moreover, they showed also larger volumes in a comparable set of regions than the less intensively practicing musicians. The structural changes in the sensory and motor systems correspond well to the behavioral results, and can be interpreted in terms of plasticity as a result of intensive motor training. Areas of the superior parietal lobule and the entorhinal cortex might be enlarged in musicians due to their special skills in sight-playing and memorizing of scores. In conclusion, intensive and specific musical training seems to have an impact on brain structure, not only during the sensitive period of childhood but throughout life.

  4. Adaptively evolved yeast mutants on galactose show trade-offs in carbon utilization on glucose

    DEFF Research Database (Denmark)

    Hong, Kuk-Ki; Nielsen, Jens

    2013-01-01

    Adaptive evolution offers many opportunities in metabolic engineering; however, several constraints still exist as evolutionary trade-offs may impose collateral cost to obtain new traits. The application of adaptive evolution for strains development could be further improved by elucidating the molecular mechanisms. In this study, adaptively evolved yeast mutants with improved galactose utilization ability showed impaired glucose utilization. The molecular genetic basis of this trade-off was investigated using a systems biology approach. Transcriptional and metabolic changes resulting from the improvement of galactose utilization were found maintained during growth on glucose. Moreover, glucose repression related genes showed conserved expression patterns during growth on both sugars. Mutations in the RAS2 gene that were identified as beneficial for galactose utilization in evolved mutants exhibited significant correlation with attenuation of glucose utilization. These results indicate that antagonistic pleiotropy is the dominant mechanism in the observed trade-off, and it is likely realized by changes in glucose signaling. © 2013 Elsevier Inc.

  5. Porn video shows, local brew, and transactional sex: HIV risk among youth in Kisumu, Kenya

    OpenAIRE

    Voeten Helene ACM; Njue Carolyne; Remes Pieter

    2011-01-01

    Abstract Background Kisumu has shown a rising HIV prevalence over the past sentinel surveillance surveys, and most new infections are occurring among youth. We conducted a qualitative study to explore risk situations that can explain the high HIV prevalence among youth in Kisumu town, Kenya Methods We conducted in-depth interviews with 150 adolescents aged 15 to 20, held 4 focus group discussions, and made 48 observations at places where youth spend their free time. Results Porn video shows a...

  6. Soya bean tempe extracts show antibacterial activity against Bacillus cereus cells and spores

    OpenAIRE

    Roubos-van den Hil, P.J.; Dalmas, E.; Nout, M.J.R.; Abee, T.

    2010-01-01

    Aims: Tempe, a Rhizopus ssp.-fermented soya bean food product, was investigated for bacteriostatic and/or bactericidal effects against cells and spores of the food-borne pathogen Bacillus cereus. Methods and results: Tempe extract showed a high antibacterial activity against B. cereus ATCC 14579 based on optical density and viable count measurements. This growth inhibition was manifested by a 4 log CFU ml?1 reduction, within the first 15 min of exposure. Tempe extracts also rapidly inactivate...

  7. Revisiting Growth and Poverty Reduction in Indonesia: What Do Subnational Data Show?

    OpenAIRE

    Balisacan, Arsenio M.; Pernia, Ernesto M.; Asra, Abuzar

    2002-01-01

    "Indonesia has an impressive record of economic growth and poverty reduction over the past two decades. The growth-poverty nexus appears strong at the aggregate level. Newly constructed panel data on the country's 285 districts (kotamadyas/kabupatens), however, reveal huge differences in poverty changes, subnational economic growth, and local attributes. Results of econometric analysis show that besides growth, other factors directly influence the welfare of the poor, apart from their impact ...

  8. Polyol-mediated C-dot formation showing efficient Tb3+/Eu3+ emission.

    Science.gov (United States)

    Dong, Hailong; Kuzmanoski, Ana; Gössl, Dorothee M; Popescu, Radian; Gerthsen, Dagmar; Feldmann, Claus

    2014-07-18

    C-dots (3-5 nm in diameter) obtained by most simple heating of polyols (glycerol, diethylene glycol and PEG 400) show intense blue and green emission (50% quantum yield). Upon modification with TbCl3/EuCl3, energy transfer from the C-dots to the rare-earth metal results in line-type Tb(3+) (green)/Eu(3+) (red) emission with quantum yields up to 85%. PMID:24887063

  9. Results of cisternography

    International Nuclear Information System (INIS)

    In a retrospective and prospective study the scintigraphically measured kinetics of intrathecally injected tracers are classified and compared with the final clinical diagnoses confirmed by additional examinations and clinical course. The results of the studies show characteristic dynamics of the tracer in patients without neurological diseases, whereas typically abnormal images are demonstrated in different neurological diseases. (orig.)

  10. Neutron spectra at different High Flux Isotope Reactor (HFIR) pressure vessel surveillance locations

    International Nuclear Information System (INIS)

    This project addresses the potential problem of radiation embrittlement of reactor pressure vessel (RPV) supports. Surveillance specimens irradiated at the High Flux Isotope Reactor (HFIR) at relatively low neutron flux levels (about 1.5E + 8 cm-2.s-1) and low temperatures (about 50 degrees C) showed embrittlement more rapidly than expected. Commercial power reactors have similar flux levels and temperatures at the level vessel support structures. The purposes of this work are to provide the neutron fluence spectra data that are needed to evaluate previously measured mechanical property changes in the HFIR, to explain the discrepancies in neutron flux levels between the nickel dosimeters and two other dosimeters, neptunium and beryllium, and to address any questions or peculiarities of the HFIR reactor environment. The current work consists of neutron and gamma transport calculations, dosimetry measurements, and least-squares logarithmic adjustment to obtain the best estimates for the neutron spectra and the related neutron exposure parameters. The results indicate that the fission rates in neptunium-237 (Np-237) and uranium-238 (U-238) and the helium production rates in beryllium-9 (Be-9) are dominated by photo-induced reactions. The displacements per atom rate for iron (dpa/s) from gamma rays is five times higher than the dpa/s from neutrons. The neutron fluxes in key 7, position 5 do not show any significant gradient in the surveillance capsule, but key 4 and key 2 showed differences in magnitude as well as in the shape of the spectrum. The stainless steel monitor in the V-notch of the Charpy specimens of the surveillance capsules is adequate to determine the neutron flux above 1.0 MeV at the desired V-notch location. Simultaneous adjustment of neutron and gamma fluxes with the measurements has been demonstrated and should avoid future problems with photo-induced reactions

  11. Examination of parameters affecting overload fracture behavior of flaw-tip hydrides in Zr-2.5Nb pressure tubes in Candu reactors

    International Nuclear Information System (INIS)

    Service-induced flaws in Zr-2.5Nb alloy pressure tubes in Candu (Canada Deuterium Uranium Reactors) nuclear reactors are susceptible to a crack initiation and growth mechanism known as Delayed Hydride Cracking (DHC), which is a repetitive process that involves hydrogen diffusion, hydride precipitation, growth and fracture of a hydride region at the flaw-tip under a constant load. Crack initiation may also occur under another loading condition when the hydride region is subjected to an overload. An overload occurs when the hydride region at the flaw tip is loaded to a stress higher than that at which this region is formed such as when the reactor experiences a transient pressure higher than the normal operating pressure where the hydride region is formed. Flaw disposition requires justification that the hydride region overload will not fracture the hydride region, and initiate DHC. In this work, monotonically increasing load experiments were performed on unirradiated Zr-2.5Nb pressure tube specimens containing simulated debris frets (V-notch) and bearing pad frets (BPF, U-shape notch) to examine overload fracture behavior of flaw-tip hydrides formed under hydride ratcheting conditions. Hydride cracking in the overload tests was detected by the acoustic emission technique and confirmed by post-test metallurgical examination. Test results indicate that the resistance to overload fracture is affected by a number of parameters including hydride formation stress, flaw shapeuding hydride formation stress, flaw shape (V-notch vs. BPF) and flaw radius (0.015 mm vs. 0.1 mm). The notch-tip hydride morphologies were examined by optical microscopy and scanning electron microscopy (SEM) which show that they are affected by the hydride formation conditions, resulting in different overload fracture resistance. Finite element stress analyses were also performed to obtain flaw-tip stress distributions for interpretation of the test results. (authors)

  12. Quest for the Best: How to Measure Central Bank Independence and Show its Relationship with Inflation

    Directory of Open Access Journals (Sweden)

    Aleksandra A. Maslowska

    2011-08-01

    Full Text Available The objective of this paper is to check measures for explanatory power of central bank independence (CBI in a series of econometric tests. Measures of central bank autonomy offer a useful expression of the extent to which a central bank is able to keep the government away from influencing a change in the inflation rate. The more a measure represents this idea, the easier one can find a relation between the CBI value and the inflation rate. Results of estimations show that proxies by Grilli et al. (1991 are strong regressors of inflation rate, contrary to those by Cukierman et al. (1992. Moreover, estimation results challenge the belief that divergences in CBI-inflation rate estimations are due to differences in institutional features across samples of countries, not to differences in legal proxies of central bank independence. Already results from a homogenous group of industrial countries indicate that some indices perform “better” than others.

  13. Eisosomes are dynamic plasma membrane domains showing pil1-lsp1 heteroligomer binding equilibrium.

    Science.gov (United States)

    Olivera-Couto, Agustina; Salzman, Valentina; Mailhos, Milagros; Digman, Michelle A; Gratton, Enrico; Aguilar, Pablo S

    2015-04-01

    Eisosomes are plasma membrane domains concentrating lipids, transporters, and signaling molecules. In the budding yeast Saccharomyces cerevisiae, these domains are structured by scaffolds composed mainly by two cytoplasmic proteins Pil1 and Lsp1. Eisosomes are immobile domains, have relatively uniform size, and encompass thousands of units of the core proteins Pil1 and Lsp1. In this work we used fluorescence fluctuation analytical methods to determine the dynamics of eisosome core proteins at different subcellular locations. Using a combination of scanning techniques with autocorrelation analysis, we show that Pil1 and Lsp1 cytoplasmic pools freely diffuse whereas an eisosome-associated fraction of these proteins exhibits slow dynamics that fit with a binding-unbinding equilibrium. Number and brightness analysis shows that the eisosome-associated fraction is oligomeric, while cytoplasmic pools have lower aggregation states. Fluorescence lifetime imaging results indicate that Pil1 and Lsp1 directly interact in the cytoplasm and within the eisosomes. These results support a model where Pil1-Lsp1 heterodimers are the minimal eisosomes building blocks. Moreover, individual-eisosome fluorescence fluctuation analysis shows that eisosomes in the same cell are not equal domains: while roughly half of them are mostly static, the other half is actively exchanging core protein subunits. PMID:25863055

  14. Retroviral DNA Integration: ASLV, HIV, and MLV Show Distinct Target Site Preferences

    Directory of Open Access Journals (Sweden)

    Mitchell Rick S

    2004-01-01

    Full Text Available The completion of the human genome sequence has made possible genome-wide studies of retroviral DNA integration. Here we report an analysis of 3,127 integration site sequences from human cells. We compared retroviral vectors derived from human immunodeficiency virus (HIV, avian sarcoma-leukosis virus (ASLV, and murine leukemia virus (MLV. Effects of gene activity on integration targeting were assessed by transcriptional profiling of infected cells. Integration by HIV vectors, analyzed in two primary cell types and several cell lines, strongly favored active genes. An analysis of the effects of tissue-specific transcription showed that it resulted in tissue-specific integration targeting by HIV, though the effect was quantitatively modest. Chromosomal regions rich in expressed genes were favored for HIV integration, but these regions were found to be interleaved with unfavorable regions at CpG islands. MLV vectors showed a strong bias in favor of integration near transcription start sites, as reported previously. ASLV vectors showed only a weak preference for active genes and no preference for transcription start regions. Thus, each of the three retroviruses studied showed unique integration site preferences, suggesting that virus-specific binding of integration complexes to chromatin features likely guides site selection.

  15. Ageing research on vertebrates shows knowledge gaps and opportunities for species conservation and management

    DEFF Research Database (Denmark)

    Conde, Dalia Amor

    Ageing theories predict that evolution should inevitably lead to an increase of mortality and decrease of fertility with age. However, a recent study across different species shows that this prediction only applies to really few species. In fact there is a great diversity of mortality trajectories in nature. Additionally, empirical studies have previously concluded that age matters: the probabilities of species to die as a function of age are highly diverse. Some species even show that mortality decreases with age (negative senescence). Albeit these findings, most studies still assume that mortality is constant when species reach maturity. The implications of these assumptions have strong consequences not only in the development of evolutionary theories of ageing and population ecology but also in species conservation. By modeling mortality of different species of vertebrates we show that different models are needed to explore the diversity of mortality trajectories in animals. However, our state of demographic knowledge even for vertebrates is by far deficient to incorporate the effects on age. Exploring 13 available datasets on vertebrate life histories traits, our results show surprising figures that highlight the urgency to fill up knowledge gaps to manage populations of threatened species.

  16. Grain size and temperature influence on the toughness of a CuAlBe shape memory alloy

    International Nuclear Information System (INIS)

    Research highlights: ? This work evaluated the capacity of a CuAlBe alloy to absorb energy until rupture. ? The V-notch Charpy test was adopted at -150, -100, -50, 0, 50, 100 and 150 deg. C. ? Charpy tests were complemented by DSC, DSC with optical microscope and by SEM. ? First work to analyze the toughness of a CuAlBe alloy based on the Charpy test. ? The results are of relevant value to enhance the understanding of the CuAlBe alloy. - Abstract: This work is a study of the influence of grain size and temperature on the toughness of CuAlBe shape memory alloys with (CuAlBeNbNi) and without NbNi (CuAlBe) grain refiner elements. The toughness analysis was based on the V-notch Charpy impact test under temperatures of -150, -100, -50, 0, 50, 100 and 150 deg. C. A statistical analysis of the results led to the conclusion that the toughness of both alloys was influenced by temperature and grain size. The CuAlBeNbNi alloy absorbed higher impact energy than the CuAlBe alloy showing that the refining elements improved the toughness of the alloy. To confirm and complement these findings, the fracture surfaces were evaluated by stereomicroscopy. Smooth homogeneous surfaces and rough heterogonous surfaces were detected for the CuAlBeNbNi and CuAlBe alloys, respectively. Predominately brittle zones were confirmed by scanning electron microscopy in both alloys. Furthermore, to determine the phase transformation temperatures and the associated microstructures, the alloys wed microstructures, the alloys were assessed by conventional differential scanning calorimetry (DSC) and DSC with optical microscopy.

  17. Input-anticipating critical reservoirs show power law forgetting of unexpected input events.

    Science.gov (United States)

    Mayer, Norbert Michael

    2015-05-01

    Usually reservoir computing shows an exponential memory decay. This letter investigates under which circumstances echo state networks can show a power law forgetting. That means traces of earlier events can be found in the reservoir for very long time spans. Such a setting requires critical connectivity exactly at the limit of what is permissible according to the echo state condition. However, for general matrices, the limit cannot be determined exactly from theory. In addition, the behavior of the network is strongly influenced by the input flow. Results are presented that use certain types of restricted recurrent connectivity and anticipation learning with regard to the input, where power law forgetting can indeed be achieved. PMID:25774542

  18. A Case of Budd-Chiari Syndrome Which Shows Space Occupying Lesion on Liver Scan

    International Nuclear Information System (INIS)

    A twenty-one-year old man visited our hospital due to abdominal distension for a month. On the physical examination, there was severe abdominal distension with fluctuation and shifting dullness. The routine laboratory results were within normal range. On the Magnetic Resonance angiography, there wasn't any blood flow within the right and middle hepatic vein. So we concluded that the etiologic disease was Budd Chiari syndrome. On the liver scan, there was cold area (absence of radiouptake) on entire right lobe of the liver, increased uptake on the bone marrow and showed splenomegaly. This finding was similar to the liver mass occupying right lobe with underlying chronic liver disease. On the previous reports, it is quite uncommon finding that Budd-Chirari syndrome shows lesion like space occupying one on the liver scan. So we report this case with a review of the literature.

  19. Strains of the soil fungus Mortierella show different degradation potentials for the phenylurea herbicide diuron

    DEFF Research Database (Denmark)

    Ellegaard-Jensen, Lea; Aamand, jens

    2013-01-01

    Microbial pesticide degradation studies have until now mainly focused on bacteria, although fungi have also been shown to degrade pesticides. In this study we clarify the background for the ability of the common soil fungus Mortierella to degrade the phenylurea herbicide diuron. Diuron degradation potentials of five Mortierella strains were compared, and the role of carbon and nitrogen for the degradation process was investigated. Results showed that the ability to degrade diuron varied greatly among the Mortierella strains tested, and the strains able to degrade diuron were closely related. Degradation of diuron was fastest in carbon and nitrogen rich media while suboptimal nutrient levels restricted degradation, making it unlikely that Mortierella utilize diuron as carbon or nitrogen sources. Degradation kinetics showed that diuron degradation was followed by formation of the metabolites 1-(3,4-dichlorophenyl)-3-methylurea, 1-(3,4-dichlorophenyl)urea and an hitherto unknown metabolite suggested to be 1-(3,4-dichlorophenyl)-3-methylideneurea.

  20. Alzheimer's-associated A? oligomers show altered structure, immunoreactivity and synaptotoxicity with low doses of oleocanthal

    International Nuclear Information System (INIS)

    It now appears likely that soluble oligomers of amyloid-?1-42 peptide, rather than insoluble fibrils, act as the primary neurotoxin in Alzheimer's disease (AD). Consequently, compounds capable of altering the assembly state of these oligomers (referred to as ADDLs) may have potential for AD therapeutics. Phenolic compounds are of particular interest for their ability to disrupt A? oligomerization and reduce pathogenicity. This study has focused on oleocanthal (OC), a naturally-occurring phenolic compound found in extra-virgin olive oil. OC increased the immunoreactivity of soluble A? species, when assayed with both sequence- and conformation-specific A? antibodies, indicating changes in oligomer structure. Analysis of oligomers in the presence of OC showed an upward shift in MW and a ladder-like distribution of SDS-stable ADDL subspecies. In comparison with control ADDLs, oligomers formed in the presence of OC (A?-OC) showed equivalent colocalization at synapses but exhibited greater immunofluorescence as a result of increased antibody recognition. The enhanced signal at synapses was not due to increased synaptic binding, as direct detection of fluorescently-labeled ADDLs showed an overall reduction in ADDL signal in the presence of OC. Decreased binding to synapses was accompanied by significantly less synaptic deterioration assayed by drebrin loss. Additionally, treatment with OC improved antibody clearance of ADDLs. These results indicate oleocanthaLs. These results indicate oleocanthal is capable of altering the oligomerization state of ADDLs while protecting neurons from the synaptopathological effects of ADDLs and suggest OC as a lead compound for development in AD therapeutics.

  1. Magnetite, a model system for mixed-valence oxides, does not show charge ordering

    International Nuclear Information System (INIS)

    We have investigated the charge ordering (CO) in magnetite below the Verwey transition. A new set of half-integer and mixed-integer superlattice reflections of the low-temperature phase have been studied by x-ray resonant scattering. None of these reflections show features characteristic of CO. We demonstrate the absence of CO along the c axis with the periodicity of either the cubic lattice q=(001) or the doubled cubic lattice q=(001/2). This result suggests that the Verwey transition is caused by strong electron-phonon interaction instead of an electronic ordering on the octahedral Fe atoms

  2. Lithium inclusion in indium metal-organic frameworks showing increased surface area and hydrogen adsorption

    International Nuclear Information System (INIS)

    Investigation of counterion exchange in two anionic In-Metal-Organic Frameworks (In-MOFs) showed that partial replacement of disordered ammonium cations was achieved through the pre-synthetic addition of LiOH to the reaction mixture. This resulted in a surface area increase of over 1600% in (Li [In(1,3 ? BDC)2])n and enhancement of the H2 uptake of approximately 275% at 80?000 Pa at 77 K. This method resulted in frameworks with permanent lithium content after repeated solvent exchange as confirmed by inductively coupled plasma mass spectrometry. Lithium counterion replacement appears to increase porosity after activation through replacement of bulkier, softer counterions and demonstrates tuning of pore size and properties in MOFs

  3. Lithium inclusion in indium metal-organic frameworks showing increased surface area and hydrogen adsorption

    Energy Technology Data Exchange (ETDEWEB)

    Bosch, Mathieu; Zhang, Muwei; Feng, Dawei; Yuan, Shuai; Wang, Xuan [Department of Chemistry, Texas A and M University, College Station, Texas 77842 (United States); Chen, Ying-Pin [Department of Materials Science and Engineering, Texas A and M University, College Station, Texas 77842 (United States); Zhou, Hong-Cai, E-mail: zhou@mail.chem.tamu.edu [Department of Chemistry, Texas A and M University, College Station, Texas 77842 (United States); Department of Materials Science and Engineering, Texas A and M University, College Station, Texas 77842 (United States)

    2014-12-01

    Investigation of counterion exchange in two anionic In-Metal-Organic Frameworks (In-MOFs) showed that partial replacement of disordered ammonium cations was achieved through the pre-synthetic addition of LiOH to the reaction mixture. This resulted in a surface area increase of over 1600% in (Li [In(1,3 ? BDC){sub 2}]){sub n} and enhancement of the H{sub 2} uptake of approximately 275% at 80?000 Pa at 77 K. This method resulted in frameworks with permanent lithium content after repeated solvent exchange as confirmed by inductively coupled plasma mass spectrometry. Lithium counterion replacement appears to increase porosity after activation through replacement of bulkier, softer counterions and demonstrates tuning of pore size and properties in MOFs.

  4. Lithium inclusion in indium metal-organic frameworks showing increased surface area and hydrogen adsorption

    Directory of Open Access Journals (Sweden)

    Mathieu Bosch

    2014-12-01

    Full Text Available Investigation of counterion exchange in two anionic In-Metal-Organic Frameworks (In-MOFs showed that partial replacement of disordered ammonium cations was achieved through the pre-synthetic addition of LiOH to the reaction mixture. This resulted in a surface area increase of over 1600% in {Li [In(1,3 ? BDC2]}n and enhancement of the H2 uptake of approximately 275% at 80?000 Pa at 77 K. This method resulted in frameworks with permanent lithium content after repeated solvent exchange as confirmed by inductively coupled plasma mass spectrometry. Lithium counterion replacement appears to increase porosity after activation through replacement of bulkier, softer counterions and demonstrates tuning of pore size and properties in MOFs.

  5. Live Reporting in a News / Current Affairs TV Show as a Factor of (Non Credibility

    Directory of Open Access Journals (Sweden)

    Tena Perišin

    2010-12-01

    Full Text Available Only a perfunctory glance at the content of current aff airs/news programs makes it clear that in just a few years time, live reporting on Croatian TV news shows has increased dramatically. Technologicaladvancements, the equipping of TV stations with mobile satellite vans, and the pressure of competition have all resulted in increased instances of live reporting. When investigating news values, pictureand sound, as well as the possibility of immediate, timely reporting represent the key characteristics of TV journalism. In this context, live reports, as part of a news segment, should add to the authenticity and credibility of the program. Currently, however, TV broadcasting houses attempt to best one another in the number of live broadcasts as a means to purport a higher quality of their program. The direct address to the camera turns a reporter from an anonymous bearer of information into the “main star”. The figures accumulated on the extent of this form used in a news show do not determine the professional level of the editorial policy. Live reporting cannot be regarded as news value if other news values are neglected in the process. Recent research shows that live reports, in most cases, have been stripped of the initial notion of reporting on important and recent events. As such, they are becoming less of a justifi ed element in the creation of news.

  6. Radon in Austrian tourist mines and show caves; Radon in oesterreichischen Schaubergwerken und -hoehlen

    Energy Technology Data Exchange (ETDEWEB)

    Ringer, W.; Graeser, J. [Oesterreichische Agentur fuer Gesundheit und Ernaehrungssicherheit (AGES GmbH), Linz (Austria). Kompetenzzentrum Radiooekologie und Radon; Aspek, W. [Allgemeine Unfallversicherungsanstalt (AUVA), Wien (Austria). Abt. fuer Unfallverhuetung und Berufskrankheitenbekaempfung; Gschnaller, J. [GT-Analytic KEG, Innsbruck (Austria)

    2009-07-01

    The radon situation in tourist mines and show caves is barely investigated in Austria. This paper investigates the influence of its determining factors, such as climate, structure and geology. For this purpose, long-term time-resolved measurements over 6 to 12 months in 4 tourist mines and 2 show caves - with 5 to 9 measuring points each - have been carried out to obtain the course of radon concentration throughout the year. In addition, temperature and air-pressure were measured and compared to the data outside where available. Results suggest that the dominating factors of the average radon concentration are structure and location (geology) of the tunnel-system, whereas the diurnal and annual variation is mainly caused by the changing airflow, which is driven by the difference in temperature inside and outside. Downcast air is connected with very low radon concentrations, upcast air with high concentrations. In some locations the maximum values appear when the airflow ceases. But airflow can be different in different parts of mines and caves. Systems close to the surface show generally lower radon levels than the ones located deeper underground. Due to variation of structure, geology and local climate, the radon situation in mines and caves can only be described by simultaneous measurements at several measuring points. (orig.)

  7. Do dolphins rehearse show-stimuli when at rest? Delayed matching of auditory memory

    Directory of Open Access Journals (Sweden)

    DorotheeKremers

    2011-12-01

    Full Text Available The mechanisms underlying vocal mimicry in animals remain an open question. Delphinidae are able to copy sounds from their environment that are not produced by conspecifics. Usually, these mimicries occur associated with the context in which they were learned. No reports address the question of separation between auditory memory formation and spontaneous vocal copying although the sensory and motor phases of vocal learning are separated in a variety of songbirds. Here we show that captive bottlenose dolphins produce, during their nighttime resting periods, non-dolphin sounds that they heard during performance shows. Generally, in the middle of the night, these animals produced vocal copies of whale sounds that had been broadcast during daily public shows. As their life history was fully known, we know that these captive dolphins had never had the opportunity to hear whale sounds before then. Moreover, recordings made before the whale sounds started being broadcast revealed that they had never emitted such sounds before. This is to our knowledge the first evidence for a separation between formation of auditory memories and the process of learning to produce calls that match these memories in a marine mammal. One hypothesis is that dolphins may rehearse some special events heard during the daytime and that they then express vocally what could be conceived as a more global memory. These results open the way for broader views on how animals might rehearse life events while resting or maybe dreaming.

  8. Insisting on Depression, but not Showing Symptoms: A Japanese Study of Excuse-Making

    Directory of Open Access Journals (Sweden)

    Itsuki Yamakawa

    2015-05-01

    Full Text Available Since the late 1990s, Japanese psychiatrists have reported the appearance of a Modern Type Depression (MTD, which has different features from melancholic depression. Using a case vignette method, we looked at one of the distinctive features of MTD; that is, “insisting on depression”. In particular, we examined whether the statement “I think I may have depressive disorder” can be accepted as an excuse for not fulfilling ones’ duty when one does not show any symptoms of depressive disorder. Participants comprised 344 Japanese undergraduates who were presented with a short scenario describing social predicaments and who subsequently assessed the excuse value in terms of impression and behavioral reaction on the transgressor. Results showed that even though the transgressor did not show any symptoms of depressive disorder, insisting that one may have depressive disorder seemed to be accepted. Additionally, consistent with Weiner’s cognitive (attribution–emotion–action model, the more positive impressions observers have on the transgressor, the more they are motivated to react kindly to the transgressor. Some unexpected findings and limitations of the present study were discussed.

  9. Do bilinguals show neural differences with monolinguals when processing their native language?

    Science.gov (United States)

    Palomar-García, María-Ángeles; Bueichekú, Elisenda; Ávila, César; Sanjuán, Ana; Strijkers, Kristof; Ventura-Campos, Noelia; Costa, Albert

    2015-03-01

    The present research used fMRI to measure brain activity in passive listening and picture-naming tasks with a group of early high proficient Spanish-Catalan bilinguals, in which Spanish was dominant, and a group of Spanish monolinguals. Both tasks were conducted in Spanish and the effect of cognateness was studied. The behavioural results showed slow naming responses in bilinguals. The fMRI results revealed that bilinguals and monolinguals differed only during the picture naming task. Unlike previous results, obtained mainly with L2, monolinguals displayed more activity in receptive language areas and less activity in the posterior cingulate cortex and right STG in the picture-naming task than bilinguals. As far as we know, this is the first study to investigate the neural basis of L1 processing in bilinguals and monolinguals by performing the task in the same language and in a monolingual context. The results indicate more efficient use of language networks in monolinguals because bilinguals utilised a more distributed network, which may imply subtle processing disadvantages. PMID:25658632

  10. Neuraminidase is essential for fowl plague virus hemagglutinin to show hemagglutinating activity.

    Science.gov (United States)

    Ohuchi, M; Feldmann, A; Ohuchi, R; Klenk, H D

    1995-09-10

    When hemagglutinin (HA) of fowl plague virus (FPV) was expressed in CV-1 cells by a simian virus 40 vector, hemadsorption was barely detectable, although HA was exposed at the cell surface. However, treatment of HA-expressing cells with Vibrio cholerae neuraminidase (VCNA) resulted in extensive hemadsorption. VCNA treatment enhanced the electrophoretic mobility of the HA1 subunit of HA, indicating the removal of sialic acid. When two oligosaccharides in the vicinity of the receptor binding site of FPV HA were deleted by site-specific mutagenesis, VCNA treatment was not required for hemadsorption. Mutants which retained one of these oligosaccharides and mutants in which oligosaccharides not adjacent to the receptor binding site were deleted needed VCNA treatment to show hemadsorption. VCNA treatment also enhanced hemadsorption of vector-expressed HA of the WSN strain, which had a complex-type oligosaccharide in the vicinity of the receptor binding site, but had no effect on hemadsorption of Hong Kong type HA, which has a high-mannose type oligosaccharide adjacent to the receptor binding site. These results indicate that sialic acid on oligosaccharides near the receptor binding site interferes with hemadsorption. Thus, the neuraminidase is essential for FPV HA to show hemagglutinating activity. PMID:7676651

  11. A physical map of Brassica oleracea shows complexity of chromosomal changes following recursive paleopolyploidizations

    Directory of Open Access Journals (Sweden)

    Giattina Emily

    2011-09-01

    Full Text Available Abstract Background Evolution of the Brassica species has been recursively affected by polyploidy events, and comparison to their relative, Arabidopsis thaliana, provides means to explore their genomic complexity. Results A genome-wide physical map of a rapid-cycling strain of B. oleracea was constructed by integrating high-information-content fingerprinting (HICF of Bacterial Artificial Chromosome (BAC clones with hybridization to sequence-tagged probes. Using 2907 contigs of two or more BACs, we performed several lines of comparative genomic analysis. Interspecific DNA synteny is much better preserved in euchromatin than heterochromatin, showing the qualitative difference in evolution of these respective genomic domains. About 67% of contigs can be aligned to the Arabidopsis genome, with 96.5% corresponding to euchromatic regions, and 3.5% (shown to contain repetitive sequences to pericentromeric regions. Overgo probe hybridization data showed that contigs aligned to Arabidopsis euchromatin contain ~80% of low-copy-number genes, while genes with high copy number are much more frequently associated with pericentromeric regions. We identified 39 interchromosomal breakpoints during the diversification of B. oleracea and Arabidopsis thaliana, a relatively high level of genomic change since their divergence. Comparison of the B. oleracea physical map with Arabidopsis and other available eudicot genomes showed appreciable 'shadowing' produced by more ancient polyploidies, resulting in a web of relatedness among contigs which increased genomic complexity. Conclusions A high-resolution genetically-anchored physical map sheds light on Brassica genome organization and advances positional cloning of specific genes, and may help to validate genome sequence assembly and alignment to chromosomes. All the physical mapping data is freely shared at a WebFPC site (http://lulu.pgml.uga.edu/fpc/WebAGCoL/brassica/WebFPC/; Temporarily password-protected: account: pgml; password: 123qwe123.

  12. Diabetes patients show different time-course of myocardial perfusion improvement after coronary artery bypass grafting

    Energy Technology Data Exchange (ETDEWEB)

    Lee, J. J.; Seok, J. W.; Eo, J. S. [Seoul National University Hospital, Seoul (Korea, Republic of)] (and others)

    2005-07-01

    Diabetes mellitus is an independent risk factor of cardiovascular disease. Diabetes is known to cause microangiopathy. The microangiopathy is hardly detectable on the coronary angiography. Myocardial perfusion imaging shows the resultant perfusion status which reflects the microangiopathy. For patients who underwent revascularization, the microangiopathy could affect the myocardial perfusion improvement. Diabetes patients probably experience the different myocardial perfusion improvement as compared to the non-diabetes patients although they have similar angiographic findings. The aim of this study is to find out whether there is a time-course difference of perfusion improvement between the diabetes and non diabetes patients who showed patent angiographic findings after coronary artery grafting surgery (CABG). A total of 129 patients who underwent coronary artery bypass grafting surgery were enrolled in this study. Myocardial SPECTs performed at previous, short-term (3 month), and mid-term (1 year) to CABG. One-year follow up angiography was done 411{+-}121 days after surgery. Graft patency was determined according to the FitzGibbon et al. Segments were assigned to vascular territories using a 20 segment model. The segments of excellent patency were included in this study. Time course differences of concerned segments were analyzed using RMANOVA. The number of segments enrolled was 764 of diabetes and 1083 of non-diabetes. At short-term follow up, reversibility score was 2.8{+-}8.1% in diabetes and 0.3{+-}7.5% in non-diabetes. At long-term follow up, reversibility score was 1.8{+-}8.0% in diabetes and 0.1{+-}7.3% in non-diabetes. The time-course of reversibility score was significantly different between the diabetes and non diabetes (p<0.001) Diabetic segments showed high residual reversibility score than non-diabetic segments after CABG although the angiographic finding was patent in both groups. This result is maybe attributable to microangiopathy induced by diabetes.

  13. Caveolin-2-deficient mice show evidence of severe pulmonary dysfunction without disruption of caveolae.

    Science.gov (United States)

    Razani, Babak; Wang, Xiao Bo; Engelman, Jeffery A; Battista, Michela; Lagaud, Guy; Zhang, Xiao Lan; Kneitz, Burkhard; Hou, Harry; Christ, George J; Edelmann, Winfried; Lisanti, Michael P

    2002-04-01

    Caveolin-2 is a member of the caveolin gene family with no known function. Although caveolin-2 is coexpressed and heterooligomerizes with caveolin-1 in many cell types (most notably adipocytes and endothelial cells), caveolin-2 has traditionally been considered the dispensable structural partner of the widely studied caveolin-1. We now directly address the functional significance of caveolin-2 by genetically targeting the caveolin-2 locus (Cav-2) in mice. In the absence of caveolin-2 protein expression, caveolae still form and caveolin-1 maintains its localization in plasma membrane caveolae, although in certain tissues caveolin-1 is partially destabilized and shows modestly diminished protein levels. Despite an intact caveolar membrane system, the Cav-2-null lung parenchyma shows hypercellularity, with thickened alveolar septa and an increase in the number of endothelial cells. As a result of these pathological changes, these Cav-2-null mice are markedly exercise intolerant. Interestingly, these Cav-2-null phenotypes are identical to the ones we and others have recently reported for Cav-1-null mice. As caveolin-2 expression is also severely reduced in Cav-1-null mice, we conclude that caveolin-2 deficiency is the clear culprit in this lung disorder. Our analysis of several different phenotypes observed in caveolin-1-deficient mice (i.e., abnormal vascular responses and altered lipid homeostasis) reveals that Cav-2-null mice do not show any of these other phenotypes, indicating a selective role for caveolin-2 in lung function. Taken together, our data show for the first time a specific role for caveolin-2 in mammalian physiology independent of caveolin-1. PMID:11884617

  14. Rhabdomyosarcoma cells show an energy producing anabolic metabolic phenotype compared with primary myocytes

    Directory of Open Access Journals (Sweden)

    Higashi Richard M

    2008-10-01

    Full Text Available Abstract Background The functional status of a cell is expressed in its metabolic activity. We have applied stable isotope tracing methods to determine the differences in metabolic pathways in proliferating Rhabdomysarcoma cells (Rh30 and human primary myocytes in culture. Uniformly 13C-labeled glucose was used as a source molecule to follow the incorporation of 13C into more than 40 marker metabolites using NMR and GC-MS. These include metabolites that report on the activity of glycolysis, Krebs' cycle, pentose phosphate pathway and pyrimidine biosynthesis. Results The Rh30 cells proliferated faster than the myocytes. Major differences in flux through glycolysis were evident from incorporation of label into secreted lactate, which accounts for a substantial fraction of the glucose carbon utilized by the cells. Krebs' cycle activity as determined by 13C isotopomer distributions in glutamate, aspartate, malate and pyrimidine rings was considerably higher in the cancer cells than in the primary myocytes. Large differences were also evident in de novo biosynthesis of riboses in the free nucleotide pools, as well as entry of glucose carbon into the pyrimidine rings in the free nucleotide pool. Specific labeling patterns in these metabolites show the increased importance of anaplerotic reactions in the cancer cells to maintain the high demand for anabolic and energy metabolism compared with the slower growing primary myocytes. Serum-stimulated Rh30 cells showed higher degrees of labeling than serum starved cells, but they retained their characteristic anabolic metabolism profile. The myocytes showed evidence of de novo synthesis of glycogen, which was absent in the Rh30 cells. Conclusion The specific 13C isotopomer patterns showed that the major difference between the transformed and the primary cells is the shift from energy and maintenance metabolism in the myocytes toward increased energy and anabolic metabolism for proliferation in the Rh30 cells. The data further show that the mitochondria remain functional in Krebs' cycle activity and respiratory electron transfer that enables continued accelerated glycolysis. This may be a common adaptive strategy in cancer cells.

  15. Transgenic plants that express the phytoplasma effector SAP11 show altered phosphate starvation and defense responses.

    Science.gov (United States)

    Lu, Yen-Ting; Li, Meng-Ying; Cheng, Kai-Tan; Tan, Choon Meng; Su, Li-Wen; Lin, Wei-Yi; Shih, Hsien-Tzung; Chiou, Tzyy-Jen; Yang, Jun-Yi

    2014-03-01

    Phytoplasmas have the smallest genome among bacteria and lack many essential genes required for biosynthetic and metabolic functions, making them unculturable, phloem-limited plant pathogens. In this study, we observed that transgenic Arabidopsis (Arabidopsis thaliana) expressing the secreted Aster Yellows phytoplasma strain Witches' Broom protein11 shows an altered root architecture, similarly to the disease symptoms of phytoplasma-infected plants, by forming hairy roots. This morphological change is paralleled by an accumulation of cellular phosphate (Pi) and an increase in the expression levels of Pi starvation-induced genes and microRNAs. In addition to the Pi starvation responses, we found that secreted Aster Yellows phytoplasma strain Witches' Broom protein11 suppresses salicylic acid-mediated defense responses and enhances the growth of a bacterial pathogen. These results contribute to an improved understanding of the role of phytoplasma effector SAP11 and provide new insights for understanding the molecular basis of plant-pathogen interactions. PMID:24464367

  16. Single particle tracking in systems showing anomalous diffusion: the role of weak ergodicity breaking

    CERN Document Server

    Burov, Stas; Metzler, Ralf; Barkai, Eli

    2010-01-01

    Anomalous diffusion has been widely observed by single particle tracking microscopy in complex systems such as biological cells. The resulting time series are usually evaluated in terms of time averages. Often anomalous diffusion is connected with non-ergodic behaviour. In such cases the time averages remain random variables and hence irreproducible. Here we present a detailed analysis of the time averaged mean squared displacement for systems governed by anomalous diffusion, considering both unconfined and restricted (corralled) motion. We discuss the behaviour of the time averaged mean squared displacement for two prominent stochastic processes, namely, continuous time random walks and fractional Brownian motion. We also study the distribution of the time averaged mean squared displacement around its ensemble mean, and show that this distribution preserves typical process characteristic even for short time series. Recently, velocity correlation functions were suggested to distinguish between these processes...

  17. Different methods to quantify Listeria monocytogenes biofilms cells showed different profile in their viability

    Scientific Electronic Library Online (English)

    Lizziane Kretli, Winkelströter; Elaine C.P. De, Martinis.

    2015-05-01

    Full Text Available Listeria monocytogenes is a foodborne pathogen able to adhere and to form biofilms in several materials commonly present in food processing plants. The aim of this study was to evaluate the resistance of Listeria monocytogenes attached to abiotic surface, after treatment with sanitizers, by culture [...] method, microscopy and Quantitative Real Time Polymerase Chain Reaction (qPCR). Biofilms of L. monocytogenes were obtained in stainless steel coupons immersed in Brain Heart Infusion Broth, under agitation at 37 °C for 24 h. The methods selected for this study were based on plate count, microscopic count with the aid of viability dyes (CTC-DAPI), and qPCR. Results of culture method showed that peroxyacetic acid was efficient to kill sessile L. monocytogenes populations, while sodium hypochlorite was only partially effective to kill attached L. monocytogenes (p

  18. Spinocerebellar ataxia type 2 olfactory impairment shows a pattern similar to other major neurodegenerative diseases.

    Science.gov (United States)

    Velázquez-Pérez, Luis; Fernandez-Ruiz, Juan; Díaz, Rosalinda; González, Ruth Pérez; Ochoa, Nalia Canales; Cruz, Gilberto Sánchez; Mederos, Luis Enrique Almaguer; Góngora, Edilberto Martínez; Hudson, Robyn; Drucker-Colin, René

    2006-09-01

    Olfactory function is affected in different neurodegenerative diseases. Recently, it has been found that some hereditary ataxias are also associated with significant olfactory impairment. However, the initial findings did not examine the nature of the olfactory impairment associated with these ataxias. In the present article the effect of spinocerebellar ataxia type 2 (SCA2) on olfactory function was studied in 53 SCA2 patients and 53 healthy control subjects from Holguín, Cuba. Several tests were applied to evaluate olfactory threshold, description, identification and discrimination. The results show significant impairment in SCA2 patients on all olfactory measurements, and the pattern of olfactory deficits found suggests that they have much in common with those reported for other neurodegenerative diseases such as Parkinson's and Alzheimer's diseases. PMID:16609806

  19. LEADING THE WAY AND SHOWING AFFILIATION: PARTICIPATORY ROLES IN A SEMI-STRUCTURED NARRATIVE INTERVIEW

    Directory of Open Access Journals (Sweden)

    Katie Paredes

    2011-10-01

    Full Text Available This paper outlines the participatory roles of narrators and interviewers in the process of unfolding personal stories. Fifteen secondary school students of Hispanic-Australian background enrolled in intermediate Spanish classes in Melbourne (Australia were asked to talk about a series of topics allowing them to explore and develop personal stories. For the purpose of providing a comprehensive corpus this manuscript focuses on the 11 personal stories that emerged in Spanish and English around the topic of ‘the worst holiday’. The results show that narratives are not initially volunteered by students, being prefaced by an initial denial of negative experience. Nevertheless, the interviewer’s participation dissipates the narrator’s initial attitude allowing students to construct narratives guided by the interviewer’s expectations. Interviewer strategies include requests for clarification, prompts for story development and co-authorship. Also crucial to the interaction is the use of laughter as a form of personal affiliation.

  20. Transgenic American elm shows reduced Dutch elm disease symptoms and normal mycorrhizal colonization.

    Science.gov (United States)

    Newhouse, Andrew E; Schrodt, Franziska; Liang, Haiying; Maynard, Charles A; Powell, William A

    2007-07-01

    The American elm (Ulmus americana L.) was once one of the most common urban trees in eastern North America until Dutch-elm disease (DED), caused by the fungus Ophiostoma novo-ulmi, eliminated most of the mature trees. To enhance DED resistance, Agrobacterium was used to transform American elm with a transgene encoding the synthetic antimicrobial peptide ESF39A, driven by a vascular promoter from American chestnut. Four unique, single-copy transgenic lines were produced and regenerated into whole plants. These lines showed less wilting and significantly less sapwood staining than non-transformed controls after O. novo-ulmi inoculation. Preliminary observations indicated that mycorrhizal colonization was not significantly different between transgenic and wild-type trees. Although the trees tested were too young to ensure stable resistance was achieved, these results indicate that transgenes encoding antimicrobial peptides reduce DED symptoms and therefore hold promise for enhancing pathogen resistance in American elm. PMID:17310333

  1. Organic molecules showing the characteristics of localised corrosion aggravation and inhibition

    International Nuclear Information System (INIS)

    Research highlights: ? Novel experiment for the discovery of localised corrosion inhibitors. ? New method of identifying inhibitors promoting random distribution of anodic currents. ? Discovery of resorcinarene acid as an effective localised corrosion inhibitor. - Abstract: The behaviour of imidazoline and an acid functionalised resorcinarene as steel corrosion inhibitors in carbon dioxide (CO2)-saturated brine solutions has been studied using an electrochemically integrated multi-electrode array namely the wire beam electrode (WBE). Both imidazoline and resorcinarene acid provided excellent inhibition to general CO2 corrosion; however imidazoline was found to aggravate localised corrosion by creating a small number of major anodes that focused on a small area of the WBE surface, leading to highly concentrated anodic dissolution. The resorcinarene acid showed distinctively different behaviour by generating a large number of minor anodes randomly distributing over the WBE surface, leading to insignificant general anodic dissolution. These results indicate that resorcinarene acid provided effective localised corrosion inhibition by promoting a random distribution of insignificant anodic currents.

  2. Hyraceum, the fossilized metabolic product of rock hyraxes (Procavia capensis): shows GABA-benzodiazepine receptor affinity

    Scientific Electronic Library Online (English)

    Andreas, Olsen; Linda C., Prinsloo; Louis, Scott; Anna K., Jäger.

    2007-12-01

    Full Text Available HYRACEUM, AN ACCRETION OF URINE AND dung of rock hyraxes (also known as rock dassies), when fossilized with age, has been used in South Africa for the traditional treatment of epilepsy. We report on tests of 14 hyraceum samples, collected at various geographical locations in South Africa, and assaye [...] d for GABA-benzodiazepine receptor affinity. Ethanolic extracts of four of the hyraceum samples assayed positive, whereas all aqueous extracts were inactive. Qualitative TLC resolution of the ethanolic extracts shows a complex mixture of constituents, with no feature being a distinguishing pattern for all four active samples. These preliminary results are not in conflict with the traditional use of hyraceum as a treatment for epilepsy by the settlers of Gamkaskloof.

  3. Metachronous metastasis- and survival-analysis show prognostic importance of lymphadenectomy for colon carcinomas

    Directory of Open Access Journals (Sweden)

    Laubert Tilman

    2012-03-01

    Full Text Available Abstract Background Lymphadenectomy is performed to assess patient prognosis and to prevent metastasizing. Recently, it was questioned whether lymph node metastases were capable of metastasizing and therefore, if lymphadenectomy was still adequate. We evaluated whether the nodal status impacts on the occurrence of distant metastases by analyzing a highly selected cohort of colon cancer patients. Methods 1,395 patients underwent surgery exclusively for colon cancer at the University of Lübeck between 01/1993 and 12/2008. The following exclusion criteria were applied: synchronous metastasis, R1-resection, prior/synchronous second carcinoma, age Results Five-year survival rates for TM + and TM- were 21% and 73%, respectively (p Conclusions Besides a higher T-category, a positive N-stage independently implies a higher probability to develop distant metastases and correlates with poor survival. Our data thus show a prognostic relevance of lymphadenectomy which should therefore be retained until conclusive studies suggest the unimportance of lmyphadenectomy.

  4. Radon in Irish Show Caves - Personal Monitoring Data From 2001-2006

    International Nuclear Information System (INIS)

    The European Directive 96/29/EURATOM and its transposition into national legislation demands the application of radiation protection measures if the presence of radon and radon decay products leads to significant increase in exposures of workers. Irish legislation further demands that laboratories carrying out radon measurements operate a high level quality assurance programme. As a result of a reconnaissance survey regular measurements of show cave guides have been made in order to assess exposure to radon in such workplaces and to ascertain that the limits set for radon are not exceeded. In 2000, an action level of 400 Bqm-3, was established. Doses in the range 0.3-12.0 mSv have been estimated for workers for the period 2001-2006

  5. Caveolin-1 null mice are viable but show evidence of hyperproliferative and vascular abnormalities.

    Science.gov (United States)

    Razani, B; Engelman, J A; Wang, X B; Schubert, W; Zhang, X L; Marks, C B; Macaluso, F; Russell, R G; Li, M; Pestell, R G; Di Vizio, D; Hou, H; Kneitz, B; Lagaud, G; Christ, G J; Edelmann, W; Lisanti, M P

    2001-10-12

    Caveolin-1 is the principal structural protein of caveolae membranes in fibroblasts and endothelia. Recently, we have shown that the human CAV-1 gene is localized to a suspected tumor suppressor locus, and mutations in Cav-1 have been implicated in human cancer. Here, we created a caveolin-1 null (CAV-1 -/-) mouse model, using standard homologous recombination techniques, to assess the role of caveolin-1 in caveolae biogenesis, endocytosis, cell proliferation, and endothelial nitric-oxide synthase (eNOS) signaling. Surprisingly, Cav-1 null mice are viable. We show that these mice lack caveolin-1 protein expression and plasmalemmal caveolae. In addition, analysis of cultured fibroblasts from Cav-1 null embryos reveals the following: (i) a loss of caveolin-2 protein expression; (ii) defects in the endocytosis of a known caveolar ligand, i.e. fluorescein isothiocyanate-albumin; and (iii) a hyperproliferative phenotype. Importantly, these phenotypic changes are reversed by recombinant expression of the caveolin-1 cDNA. Furthermore, examination of the lung parenchyma (an endothelial-rich tissue) shows hypercellularity with thickened alveolar septa and an increase in the number of vascular endothelial growth factor receptor (Flk-1)-positive endothelial cells. As predicted, endothelial cells from Cav-1 null mice lack caveolae membranes. Finally, we examined eNOS signaling by measuring the physiological response of aortic rings to various stimuli. Our results indicate that eNOS activity is up-regulated in Cav-1 null animals, and this activity can be blunted by using a specific NOS inhibitor, nitro-l-arginine methyl ester. These findings are in accordance with previous in vitro studies showing that caveolin-1 is an endogenous inhibitor of eNOS. Thus, caveolin-1 expression is required to stabilize the caveolin-2 protein product, to mediate the caveolar endocytosis of specific ligands, to negatively regulate the proliferation of certain cell types, and to provide tonic inhibition of eNOS activity in endothelial cells. PMID:11457855

  6. Caveolae-deficient endothelial cells show defects in the uptake and transport of albumin in vivo.

    Science.gov (United States)

    Schubert, W; Frank, P G; Razani, B; Park, D S; Chow, C W; Lisanti, M P

    2001-12-28

    The role of endothelial cell caveolae in the uptake and transport of macromolecules from the blood-space to the tissue-space remains controversial. To address this issue directly, we employed caveolin-1 gene knock-out mice that lack caveolin-1 protein expression and caveolae organelles. Here, we show that endothelial cell caveolae are required for the efficient uptake and transport of a known caveolar ligand, i.e. albumin, in vivo. Caveolin-1-null mice were perfused with 5-nm gold-conjugated albumin, and its uptake was followed by transmission electron microscopy. Our results indicate that gold-conjugated albumin is not endocytosed by Cav-1-deficient lung endothelial cells and remains in the blood vessel lumen; in contrast, gold-conjugated albumin was concentrated and internalized by lung endothelial cell caveolae in wild-type mice, as expected. To quantitate this defect in uptake, we next studied the endocytosis of radioiodinated albumin using aortic ring segments from wild-type and Cav-1-null mice. Interestingly, little or no uptake of radioiodinated albumin was observed in the aortic segments from Cav-1-deficient mice, whereas aortic segments from wild-type mice showed robust uptake that was time- and temperature-dependent and competed by unlabeled albumin. We conclude that endothelial cell caveolae are required for the efficient uptake and transport of albumin from the blood to the interstitium. PMID:11689550

  7. Arabidopsis thaliana transgenics overexpressing IBR3 show enhanced susceptibility to the bacterium Pseudomonas syringae.

    Science.gov (United States)

    Huang, T-Y; Desclos-Theveniau, M; Chien, C-T; Zimmerli, L

    2013-09-01

    The gene, indole-3-butyric acid (IBA)-RESPONSE (IBR) 3, is thought to participate in peroxisomal ?-oxidation of IBA to indole-3-acetic acid. Here we show that IBR3 may also play a role in Arabidopsis thaliana defence response to microbial pathogens. IBR3 is up-regulated during infection by virulent Pseudomonas syringae pv. tomato (Pst) DC3000 bacteria. Although mutant ibr3-4 did not show a pathogen phenotype, lines overexpressing IBR3 demonstrated enhanced susceptibility to Pst DC3000. Increased susceptibility phenotypes of IBR3 overexpressors were correlated with defective SA defence signalling and impairment of pattern-triggered immunity (PTI) activation. Notably, reactive oxygen species production was reduced in IBR3 overexpressors after treatment with the microbe-associated molecular patterns flg22 and efl26. Later PTI responses, such as accumulation of FRK1 transcripts and callose deposition were also reduced in transgenics overexpressing IBR3 after inoculation with the Type III secretion system deficient bacterial mutant Pst DC3000 hrcC or treatment with flg22 or elf26. Importantly, overexpression of IBR3 did not affect indole-3-acetic acid content or auxin-responsive gene expression. These results suggest a novel role for IBR3 in A. thaliana defence response against bacterial pathogens. PMID:23906045

  8. Cotton-top tamarins (Saguinus oedipus) fail to show mirror-guided self-exploration.

    Science.gov (United States)

    Hauser, M D; Miller, C T; Liu, K; Gupta, R

    2001-03-01

    To investigate the problem of inter- and intraspecific differences on the mirror test, we conducted two experiments on cotton-top tamarins. Experiment 1 employed a technique similar to one used recently on chimpanzees, and provided no evidence of mirror-mediated touching of the marked area. In a control condition, involving colored dye applied to one arm, two subjects also failed to show self-directed touching, even though they clearly looked at their newly dyed arm. Under these test conditions, cotton-top tamarins fail to show mirror-guided self-exploration. Experiment 2 examined whether this failure was due to insufficient mirror exposure, as well as other details of the testing conditions. In particular, we replicated the design of a previously successful experiment on mirror-mediated recognition in tamarins [Hauser et al., 1995], providing four new animals with a protracted period (three weeks) of mirror exposure prior to dying their hair. In parallel with results from Experiment 1, we observed no evidence of mirror-mediated behavior (recognition) in Experiment 2. PMID:11253848

  9. Transchromosomic cell model of Down syndrome shows aberrant migration, adhesion and proteome response to extracellular matrix

    Directory of Open Access Journals (Sweden)

    Cotter Finbarr E

    2009-08-01

    Full Text Available Abstract Background Down syndrome (DS, caused by trisomy of human chromosome 21 (HSA21, is the most common genetic birth defect. Congenital heart defects (CHD are seen in 40% of DS children, and >50% of all atrioventricular canal defects in infancy are caused by trisomy 21, but the causative genes remain unknown. Results Here we show that aberrant adhesion and proliferation of DS cells can be reproduced using a transchromosomic model of DS (mouse fibroblasts bearing supernumerary HSA21. We also demonstrate a deacrease of cell migration in transchromosomic cells independently of their adhesion properties. We show that cell-autonomous proteome response to the presence of Collagen VI in extracellular matrix is strongly affected by trisomy 21. Conclusion This set of experiments establishes a new model system for genetic dissection of the specific HSA21 gene-overdose contributions to aberrant cell migration, adhesion, proliferation and specific proteome response to collagen VI, cellular phenotypes linked to the pathogenesis of CHD.

  10. Genetics Show Current Decline and Pleistocene Expansion in Northern Spotted Owls

    Science.gov (United States)

    Funk, W. Chris; Forsman, Eric D.; Mullins, Thomas D.; Haig, Susan M.

    2008-01-01

    The northern spotted owl (Strix occidentalis caurina) is one of the most controversial threatened subspecies ever listed under the U.S. Endangered Species Act. Because of concern for persistence of the subspecies, logging on Federal lands in the U.S. Pacific Northwest was dramatically reduced under the Northwest Forest Plan in 1994. Despite protection of its remaining forest habitat, recent field studies show continued demographic declines of northern spotted owls. One potential threat to northern spotted owls that has not yet been shown is loss of genetic variation from population bottlenecks that can increase inbreeding depression and decrease adaptive potential. Here, we show recent genetic bottlenecks in northern spotted owls using a large genetic dataset (352 individuals from across the subspecies' range and 11 microsatellite loci). The signature of bottlenecks was strongest in Washington State, in agreement with field data. Interestingly, we also found a genetic signature of Pleistocene expansion in the same study areas where recent bottlenecks were shown. Our results provide independent evidence that northern spotted owls have recently declined, and suggest that loss of genetic variation is an emerging threat to the subspecies' persistence. Reduced effective population size (Ne), shown here in addition to field evidence for demographic decline, highlights the increasing vulnerability of this bird to extinction.

  11. Paralogous cAMP receptor proteins in Mycobacterium smegmatis show biochemical and functional divergence.

    Science.gov (United States)

    Sharma, Ritu; Zaveri, Anisha; Gopalakrishnapai, Jayashree; Srinath, Thiruneelakantan; Thiruneelakantan, Srinath; Varshney, Umesh; Visweswariah, Sandhya S

    2014-12-16

    The cyclic AMP receptor protein (CRP) family of transcription factors consists of global regulators of bacterial gene expression. Here, we identify two paralogous CRPs in the genome of Mycobacterium smegmatis that have 78% identical sequences and characterize them biochemically and functionally. The two proteins (MSMEG_0539 and MSMEG_6189) show differences in cAMP binding affinity, trypsin sensitivity, and binding to a CRP site that we have identified upstream of the msmeg_3781 gene. MSMEG_6189 binds to the CRP site readily in the absence of cAMP, while MSMEG_0539 binds in the presence of cAMP, albeit weakly. msmeg_6189 appears to be an essential gene, while the ?msmeg_0539 strain was readily obtained. Using promoter-reporter constructs, we show that msmeg_3781 is regulated by CRP binding, and its transcription is repressed by MSMEG_6189. Our results are the first to characterize two paralogous and functional CRPs in a single bacterial genome. This gene duplication event has subsequently led to the evolution of two proteins whose biochemical differences translate to differential gene regulation, thus catering to the specific needs of the organism. PMID:25434596

  12. Salvianolic acid A shows selective cytotoxicity against multidrug-resistant MCF-7 breast cancer cells.

    Science.gov (United States)

    Wang, Xin; Wang, Chunyan; Zhang, Longjiang; Li, Yanjun; Wang, Shouju; Wang, Jiandong; Yuan, Caiyun; Niu, Jia; Wang, Chengsheng; Lu, Guangming

    2015-02-01

    Multidrug resistance (MDR) is a major cause for incurable breast cancer. Salvianolic acid A (SAA), the hydrophilic polyphenolic derivative of Salvia miltiorrhiza Bunge (Danshen/Red Sage), was examined for cytotoxicities to MDR MCF-7 human breast cancer cells and their parental counterparts. We have shown that SAA inhibited proliferation, caused cell cycle arrest at the S phase, and induced apoptosis dose dependently to the two kinds of cancer cells. However, the resistant cells were significantly susceptible to the inhibition of SAA compared with the parental cells. SAA increased the level of reactive oxygen species (ROS) by 6.2-fold in the resistant cells, whereas the level of SAA-induced ROS changed only by 1.6-fold in their parental counterparts. Thus, the data showed that the selective cytotoxicity resulted from the hypersensitivity of the resistant cells to the strongly elevated ROS by SAA. In addition, SAA-triggered apoptosis was associated with increased caspase-3 activity, disrupted mitochondrial membrane potential, downregulated Bcl-2 expression, and upregulated Bax expression in the resistant cells. Moreover, SAA downregulated the level of P-glycoprotein, which was overexpressed in the resistant cells. This indicated that SAA modulated MDR. Furthermore, SAA showed higher antitumor activity than did doxorubicin in xenografts established from the resistant cells. The present work raised a possibility that SAA might be considered a potential choice to overcome MDR for the selective susceptibility of the resistant breast cancer cells to SAA treatment. PMID:25419632

  13. Preterm birth and unintentional injuries: risks to children, adolescents and young adults show no consistent pattern

    Science.gov (United States)

    Calling, Susanna; Palmér, Karolina; Jönsson, Lena; Sundquist, Jan; Winkleby, Marilyn; Sundquist, Kristina

    2012-01-01

    Aim Preterm birth is associated with a number of physical and mental health issues. The aim of this study was to find out if there was also any association between individuals born preterm in Sweden between 1984 and 2006 and the risk of unintentional injuries during childhood, adolescence and young adulthood. Methods The study followed 2,297,134 individuals, including 5.9% born preterm, from 1985 to 2007 for unintentional injuries leading to hospitalisation or death (n=244,021). The males and females were divided into four age groups: 1–5 years, 6–12 years, 13–18 years and 19–23 years. Hazard ratios were calculated for falls, transport injuries and other injuries. Results After adjusting for a comprehensive set of covariates, some of the preterm subgroups demonstrated slightly increased risks of unintentional injuries, while others showed slightly decreased risks. However, most of the estimates were borderline or non-significant in both males and females. In addition, the absolute risk differences between individuals born preterm and full term were small. Conclusion Despite the association between preterm birth and a variety of physical and mental health consequences, this study shows that there is no consistent risk pattern between preterm birth and unintentional injuries in childhood, adolescence and young adulthood. PMID:23181809

  14. Gastric cancers of Western European and African patients show different patterns of genomic instability

    Directory of Open Access Journals (Sweden)

    Mulder Chris JJ

    2011-01-01

    Full Text Available Abstract Background Infection with H. pylori is important in the etiology of gastric cancer. Gastric cancer is infrequent in Africa, despite high frequencies of H. pylori infection, referred to as the African enigma. Variation in environmental and host factors influencing gastric cancer risk between different populations have been reported but little is known about the biological differences between gastric cancers from different geographic locations. We aim to study genomic instability patterns of gastric cancers obtained from patients from United Kingdom (UK and South Africa (SA, in an attempt to support the African enigma hypothesis at the biological level. Methods DNA was isolated from 67 gastric adenocarcinomas, 33 UK patients, 9 Caucasian SA patients and 25 native SA patients. Microsatellite instability and chromosomal instability were analyzed by PCR and microarray comparative genomic hybridization, respectively. Data was analyzed by supervised univariate and multivariate analyses as well as unsupervised hierarchical cluster analysis. Results Tumors from Caucasian and native SA patients showed significantly more microsatellite instable tumors (p Conclusions Gastric cancers from SA and UK patients show differences in genetic instability patterns, indicating possible different biological mechanisms in patients from different geographical origin. This is of future clinical relevance for stratification of gastric cancer therapy.

  15. Montmorillonite enhanced ciprofloxacin transport in saturated porous media with sorbed ciprofloxacin showing antibiotic activity.

    Science.gov (United States)

    Chen, Hao; Gao, Bin; Yang, Liu-Yan; Ma, Lena Q

    2015-02-01

    Antibiotic ciprofloxacin (CIP) is immobile in the subsurface but it has been frequently detected in the aquatic system. Therefore it is important to investigate the factors impacting CIP's mobilization in aquifer. Laboratory columns packed with sand were used to test colloid-facilitated CIP transport by 1) using kaolinite or montmorillonite to mobilize presorbed-CIP in a column or 2) co-transporting with CIP by pre-mixing them before transport. The Langmuir model showed that CIP sorption by montmorillonite (23gkg(-1)) was 100 times more effective than sand or kaolinite. Even with strong CIP complexation ability to Fe/Al coating on sand surface, montmorillonite promoted CIP transport, but not kaolinite. All presorbed-CIP by sand was mobilized by montmorillonite after 3 pore volumes through co-transporting of CIP with montmorillonite. The majority of CIP was fixed onto the montmorillonite interlayer but still showed inhibition of bacteria growth. Our results suggested that montmorillonite with high CIP sorption ability can act as a carrier to enhance CIP's mobility in aquifer. PMID:25528132

  16. Montmorillonite enhanced ciprofloxacin transport in saturated porous media with sorbed ciprofloxacin showing antibiotic activity

    Science.gov (United States)

    Chen, Hao; Gao, Bin; Yang, Liu-Yan; Ma, Lena Q.

    2015-02-01

    Antibiotic ciprofloxacin (CIP) is immobile in the subsurface but it has been frequently detected in the aquatic system. Therefore it is important to investigate the factors impacting CIP's mobilization in aquifer. Laboratory columns packed with sand were used to test colloid-facilitated CIP transport by 1) using kaolinite or montmorillonite to mobilize presorbed-CIP in a column or 2) co-transporting with CIP by pre-mixing them before transport. The Langmuir model showed that CIP sorption by montmorillonite (23 g kg- 1) was 100 times more effective than sand or kaolinite. Even with strong CIP complexation ability to Fe/Al coating on sand surface, montmorillonite promoted CIP transport, but not kaolinite. All presorbed-CIP by sand was mobilized by montmorillonite after 3 pore volumes through co-transporting of CIP with montmorillonite. The majority of CIP was fixed onto the montmorillonite interlayer but still showed inhibition of bacteria growth. Our results suggested that montmorillonite with high CIP sorption ability can act as a carrier to enhance CIP's mobility in aquifer.

  17. First-born siblings show better second language skills than later born siblings

    Science.gov (United States)

    Keller, Karin; Troesch, Larissa M.; Grob, Alexander

    2015-01-01

    We examined the extent to which three sibling structure variables number of siblings, birth order, and presence of an older sibling at school age are linked to the second language skills of bilingual children. The research questions were tested using an ethnically heterogeneous sample of 1209 bilingual children with German as a second language. Controlling for children’s age, sex, nationality, number of children’s books at home, family language and parental German language skills, hierarchical regression analyses showed an inverse relationship between the number of siblings and second language skills: the more siblings a child had, the lower was his/her second language proficiency. This relationship was mediated by attendance in early education institutions. Moreover, first-born siblings showed better second language skills than later born siblings. The current study revealed that the resource dilution model, i.e., the decrease in resources for every additional sibling, holds for second language acquisition. Moreover, the results indicate that bilingual children from families with several children benefit from access to early education institutions.

  18. How does culture show? A case study of an international and interprofessional course in palliative care.

    Science.gov (United States)

    Pahor, Majda; Rasmussen, Birgit H

    2009-09-01

    Research shows slow improvement of the care of dying persons and their significant others. One of the reasons for that is the lack of palliative care education as an integral part of health professionals' undergraduate education. The paper discusses an attempt to develop innovative forms of palliative care education: an international, interprofessional and IT-supported undergraduate course for Swedish and Slovenian students of nursing, medicine, occupational therapy, physiotherapy, psychology and social work, which has been developed jointly by the two authors. One of the aims of the course has been to address differences in professional and national cultures relevant to quality in palliative care. The development and pilot implementation phases of the course were analysed qualitatively, using evaluation materials from students and teachers and from an external evaluation study. The results show that the interprofessional approach in the course enabled students to get to know other professions, as well as enabling them to work together as a team and resolve conflicts. Cultural differences between Sweden and Slovenia were not very pronounced, yet they came to the fore regarding teamwork and relationships between professions, as well as in respect of the "right thing" to do in relation to patient' problems. PMID:20602586

  19. Bacterial biofilm shows persistent resistance to liquid wetting and gas penetration

    Energy Technology Data Exchange (ETDEWEB)

    Epstein, Alexander K.; Pokroy, Boaz; Seminara, Agnese; Aizenberg, Joanna (Harvard)

    2011-09-28

    Most of the world's bacteria exist in robust, sessile communities known as biofilms, ubiquitously adherent to environmental surfaces from ocean floors to human teeth and notoriously resistant to antimicrobial agents. We report the surprising observation that Bacillus subtilis biofilm colonies and pellicles are extremely nonwetting, greatly surpassing the repellency of Teflon toward water and lower surface tension liquids. The biofilm surface remains nonwetting against up to 80% ethanol as well as other organic solvents and commercial biocides across a large and clinically important concentration range. We show that this property limits the penetration of antimicrobial liquids into the biofilm, severely compromising their efficacy. To highlight the mechanisms of this phenomenon, we performed experiments with mutant biofilms lacking ECM components and with functionalized polymeric replicas of biofilm microstructure. We show that the nonwetting properties are a synergistic result of ECM composition, multiscale roughness, reentrant topography, and possibly yet other factors related to the dynamic nature of the biofilm surface. Finally, we report the impenetrability of the biofilm surface by gases, implying defense capability against vapor-phase antimicrobials as well. These remarkable properties of B. subtilis biofilm, which may have evolved as a protection mechanism against native environmental threats, provide a new direction in both antimicrobial research and bioinspired liquid-repellent surface paradigms.

  20. Exploratory behaviour in NO-dependent cyclase mutants of Drosophila shows defects in coincident neuronal signalling

    Directory of Open Access Journals (Sweden)

    Tares Sophie

    2007-08-01

    Full Text Available Abstract Background Drosophila flies explore the environment very efficiently in order to colonize it. They explore collectively, not individually, so that when a few land on a food spot, they attract the others by signs. This behaviour leads to aggregation of individuals and optimizes the screening of mates and egg-laying on the most favourable food spots. Results Flies perform cycles of exploration/aggregation depending on the resources of the environment. This behavioural ecology constitutes an excellent model for analyzing simultaneous processing of neurosensory information. We reasoned that the decision of flies to land somewhere in order to achieve aggregation is based on simultaneous integration of signals (visual, olfactory, acoustic during their flight. On the basis of what flies do in nature, we designed laboratory tests to analyze the phenomenon of neuronal coincidence. We screened many mutants of genes involved in neuronal metabolism and the synaptic machinery. Conclusion Mutants of NO-dependent cyclase show a specifically-marked behaviour phenotype, but on the other hand they are associated with moderate biochemical defects. We show that these mutants present errors in integrative and/or coincident processing of signals, which are not reducible to the functions of the peripheral sensory cells.

  1. [Twelve-month-old infants show social preferences for native-dialect speakers].

    Science.gov (United States)

    Okumura, Yuko; Kanakogi, Yasuhiro; Takeuchi, Sachie; Itakura, Shoji

    2014-08-01

    Recent research demonstrates that social preferences for native language speakers emerge early in development, indicating that infants prefer speakers from their own society. Dialect may also be a reliable cue to group membership because it provides information about an individual's social and ethnic identity. We investigated whether infants showed social preferences toward native-dialect speakers over those with unfamiliar dialects. Infants at 9 and 12 months of age were shown videos in which two adults (a native-dialect speaker and an unfamiliar-dialect speaker) each spoke to and then offered an identical toy to the participating infants. Next, two real versions of the toys were presented to the infants in person. The 12-month-old infants preferentially reached for the toy offered by the native-dialect speaker. The 9-month-old infants also showed a preference for native-dialect speakers but this finding was not statistically significant. Our results suggest that dialects may be a reliable cue to group membership, and that infants' orientation toward members of their native community may guide their social and cultural learning. PMID:25272442

  2. A zebrafish model of glucocorticoid resistance shows serotonergic modulation of the stress response

    Directory of Open Access Journals (Sweden)

    EthanGahtan

    2012-10-01

    Full Text Available One function of glucocorticoids is to restore homeostasis after an acute stress response by providing negative feedback to stress circuits in the brain. Loss of this negative feedback leads to elevated physiological stress and may contribute to depression, anxiety and post-traumatic stress disorder. We investigated the early, developmental effects of glucocorticoid signaling deficits on stress physiology and related behaviors using a mutant zebrafish, grs357, with non-functional glucocorticoid receptors. These mutants are morphologically inconspicuous and adult-viable. A previous study of adult grs357 mutants showed loss of glucocorticoid-mediated negative feedback and elevated physiological and behavioral stress markers. Already at five days post-fertilization, mutant larvae had elevated whole body cortisol, increased expression of pro-opiomelanocortin (POMC, the precursor of adrenocorticotropic hormone (ACTH, and failed to show normal suppression of stress markers after dexamethasone treatment. Mutant larvae had larger auditory-evoked startle responses compared to wildtype sibling controls (grwt, despite having lower spontaneous activity levels. Fluoxetine (Prozac treatment in mutants decreased startle responding and increased spontaneous activity, making them behaviorally similar to wildtype. This result mirrors known effects of selective serotonin reuptake inhibitors (SSRIs in modifying glucocorticoid signaling and alleviating stress disorders in human patients. Our results suggest that larval grs357 zebrafish can be used to study behavioral, physiological and molecular aspects of stress disorders. Most importantly, interactions between glucocorticoid and serotonin signaling appear to be highly conserved among vertebrates, suggesting deep homologies at the neural circuit level and opening up new avenues for research into psychiatric conditions.

  3. Ipomoea aquatica Extract Shows Protective Action Against Thioacetamide-Induced Hepatotoxicity

    Directory of Open Access Journals (Sweden)

    A. Hamid A. Hadi

    2012-05-01

    Full Text Available In the Indian system of traditional medicine (Ayurveda it is recommended to consume Ipomoea aquatica to mitigate disorders like jaundice. In this study, the protective effects of ethanol extract of I. aquatica against liver damage were evaluated in thioacetamide (TAA-induced chronic hepatotoxicity in rats. There was no sign of toxicity in the acute toxicity study, in which Sprague-Dawley (SD rats were orally fed with I. aquatica (250 and 500 mg/kg for two months along with administration of TAA (i.p injection 200 mg/kg three times a week for two months. The results showed that the treatment of I. aquatica significantly lowered the TAA-induced serum levels of hepatic enzyme markers (ALP, ALT, AST, protein, albumin, bilirubin and prothrombin time. The hepatic content of activities and expressions SOD and CAT that were reduced by TAA were brought back to control levels by the plant extract supplement. Meanwhile, the rise in MDA level in the TAA receiving groups also were significantly reduced by I. aquatica treatment. Histopathology of hepatic tissues by H&E and Masson trichrome stains displayed that I. aquatica has reduced the incidence of liver lesions, including hepatic cells cloudy swelling, infiltration, hepatic necrosis, and fibrous connective tissue proliferation induced by TAA in rats. Therefore, the results of this study show that the protective effect of I. aquatica in TAA-induced liver damage might be contributed to its modulation on detoxification enzymes and its antioxidant and free radical scavenger effects. Moreover, it confirms a scientific basis for the traditional use of I. aquatica for the treatment of liver disorders.

  4. Combination of Pitavastatin and melatonin shows partial antineoplastic effects in a rat breast carcinoma model.

    Science.gov (United States)

    Kubatka, Peter; Bojková, Bianka; Kassayová, Monika; Orendáš, Peter; Kajo, Karol; Výbohová, Desanka; Kružliak, Peter; Adamicová, Katarína; Pé?, Martin; Stollárová, Nadežda; Adamkov, Marián

    2014-10-01

    Our previous results indicated significant tumor-suppressive effects of different statins in rat mammary carcinogenesis. The purpose of this experiment was to examine the chemopreventive effects of Pitavastatin alone and in combination with the pineal hormone melatonin in the model of N-methyl-N-nitrosourea-induced mammary carcinogenesis in female Sprague-Dawley rats. Pitavastatin was administered dietary (10mg/kg) and melatonin in an aqueous solution (20?g/ml). Chemoprevention began 7 days prior to carcinogen administration and subsequently continued for 15 weeks until autopsy. At autopsy, mammary tumors were removed and prepared for histopathological and immunohistochemical analysis. Compared to controls, Pitavastatin alone reduced average tumor volume by 58% and lengthened latency by 8 days; on the other hand, the drug increased tumor frequency by 23%. Combined administration of Pitavastatin with melatonin decreased tumor frequency by 23%, tumor volume by 44% and lengthened tumor latency by 5.5 days compared to control animals. The analysis of carcinoma cells showed significant increase in caspase-3 expression in both treated groups and a tendency of increased caspase-7 expression after Pitavastatin treatment alone. Significant expression decrease of Ki67 was found in carcinoma cells from both treated groups. Compared to control carcinoma cells, Pitavastatin alone increased VEGF expression by 41%, however melatonin totally reversed its undesirable effect. Pitavastatin combined with melatonin significantly increased femur compact bone thickness in animals. Pitavastatin alone decreased plasma triglycerides and total cholesterol levels, however it significantly increased levels of glucose. In summary, our results show a partial antineoplastic effect of Pitavastatin combined with melatonin in the rat mammary gland carcinoma model. PMID:25450902

  5. El SHOW DE JORGE BARÓN como paradigma de neopopulismo cultural en la televisión Colombiana JORGE BARON'S show as paradigm of cultural neo-populism in the colombian television

    Directory of Open Access Journals (Sweden)

    Isabel Noemí Rodríguez

    2010-12-01

    Full Text Available Este artículo parte de la investigación de campo sobre El Show de las Estrellas, el programa musical más antiguo y popular de la televisión colombiana. El análisis de caso es un pretexto para replantear la discusión sobre políticas culturales en el contexto -aparentemente paradójico- de violencia estructural, privatización y auge del populismo de derecha que caracteriza la política en Colombia en los últimos años.This article comes from the investigation field of the Stars Show (El Show de las Estrellas, the oldest and most popular musical TV show in Colombian television. The case analysis is an excuse to reframe the discussion on cultural policies in the context, apparently paradoxical, of structural violence, privatization and peak of the right populism that characterizes the Colombian politics in the last years.

  6. El SHOW DE JORGE BARÓN como paradigma de neopopulismo cultural en la televisión Colombiana / JORGE BARON'S show as paradigm of cultural neo-populism in the colombian television

    Scientific Electronic Library Online (English)

    Isabel Noemí, Rodríguez; Adolfo, Chaparro Amaya.

    2010-12-01

    Full Text Available Este artículo parte de la investigación de campo sobre El Show de las Estrellas, el programa musical más antiguo y popular de la televisión colombiana. El análisis de caso es un pretexto para replantear la discusión sobre políticas culturales en el contexto -aparentemente paradójico- de violencia es [...] tructural, privatización y auge del populismo de derecha que caracteriza la política en Colombia en los últimos años. Abstract in english This article comes from the investigation field of the Stars Show (El Show de las Estrellas), the oldest and most popular musical TV show in Colombian television. The case analysis is an excuse to reframe the discussion on cultural policies in the context, apparently paradoxical, of structural viole [...] nce, privatization and peak of the right populism that characterizes the Colombian politics in the last years.

  7. Analysis of EUVE Experiment Results

    Science.gov (United States)

    Horan, Stephen

    1996-01-01

    A series of tests to validate an antenna pointing concept for spin-stabilized satellites using a data relay satellite are described. These tests show that proper antenna pointing on an inertially-stabilized spacecraft can lead to significant access time through the relay satellite even without active antenna pointing. We summarize the test results, the simulations to model the effects of antenna pattern and space loss, and the expected contact times. We also show how antenna beam width affects the results.

  8. Vv-AMP1, a ripening induced peptide from Vitis vinifera shows strong antifungal activity

    Directory of Open Access Journals (Sweden)

    Vivier Melané A

    2008-07-01

    Full Text Available Abstract Background Latest research shows that small antimicrobial peptides play a role in the innate defense system of plants. These peptides typically contribute to preformed defense by developing protective barriers around germinating seeds or between different tissue layers within plant organs. The encoding genes could also be upregulated by abiotic and biotic stimuli during active defense processes. The peptides display a broad spectrum of antimicrobial activities. Their potent anti-pathogenic characteristics have ensured that they are promising targets in the medical and agricultural biotechnology sectors. Results A berry specific cDNA sequence designated Vv-AMP1, Vitis vinifera antimicrobial peptide 1, was isolated from Vitis vinifera. Vv-AMP1 encodes for a 77 amino acid peptide that shows sequence homology to the family of plant defensins. Vv-AMP1 is expressed in a tissue specific, developmentally regulated manner, being only expressed in berry tissue at the onset of berry ripening and onwards. Treatment of leaf and berry tissue with biotic or abiotic factors did not lead to increased expression of Vv-AMP1 under the conditions tested. The predicted signal peptide of Vv-AMP1, fused to the green fluorescent protein (GFP, showed that the signal peptide allowed accumulation of its product in the apoplast. Vv-AMP1 peptide, produced in Escherichia coli, had a molecular mass of 5.495 kDa as determined by mass spectrometry. Recombinant Vv-AMP1 was extremely heat-stable and showed strong antifungal activity against a broad spectrum of plant pathogenic fungi, with very high levels of activity against the wilting disease causing pathogens Fusarium oxysporum and Verticillium dahliae. The Vv-AMP1 peptide did not induce morphological changes on the treated fungal hyphae, but instead strongly inhibited hyphal elongation. A propidium iodide uptake assay suggested that the inhibitory activity of Vv-AMP1 might be associated with altering the membrane permeability of the fungal membranes. Conclusion A berry specific cDNA clone, Vv-AMP1, was isolated and characterized and shown to encode a plant defensin. Recombinant Vv-AMP1 displayed non-morphogenic antifungal activity against a broad spectrum of fungi, probably altering the membrane permeability of the fungal pathogens. The expression of this peptide is highly regulated in Vitis vinifera, hinting at an important defense role during berry-ripening.

  9. Akt shows variable sensitivity to an Hsp90 inhibitor depending on cell context

    International Nuclear Information System (INIS)

    Hsp90 inhibitors are currently in clinical trials for cancer therapy based on their ability to promote proteasomal degradation of oncogenic protein kinases and nuclear receptors. Results from recent studies suggest that cancer cells are more sensitive to these inhibitors than cells from healthy tissues. We analyzed an immortalized cell line Ba/F3 for sensitivity to the Hsp90 inhibitor geldanamycin in the absence and presence of the oncogenic tyrosine fusion kinase NPM-ALK expressed from a retroviral vector. Our results showed that NPM-ALK expression makes Akt and Cdk4 more resistant to degradation in the presence of geldanamycin, and there was a slightly reduced amount of apoptosis. The mechanism underlying the effect of NPM-ALK on Akt stability was probed by comparison of the turnover of the kinase after translation inhibition and geldanamycin treatment. We observed that Akt was degraded more rapidly in the presence of GA than upon translation inhibition without NPM-ALK expression. This suggests that NPM-ALK protects the mature kinase. Furthermore, Akt failed to bind to the Cdc37 chaperone in cells expressing NPM-ALK, which also correlates with increased Akt stability

  10. Lead-iodide nanowire perovskite with methylviologen showing interfacial charge-transfer absorption: a DFT analysis.

    Science.gov (United States)

    Fujisawa, Jun-ichi; Giorgi, Giacomo

    2014-09-01

    Methylviologen lead-iodide perovskite (MVPb2I6) is a self-assembled one-dimensional (1-D) material consisting of lead-iodide nanowires and intervening organic electron-accepting molecules, methylviologen (MV(2+)). MVPb2I6 characteristically shows optical interfacial charge-transfer (ICT) transitions from the lead-iodide nanowire to MV(2+) in the visible region and unique ambipolar photoconductivity, in which electrons are transported through the three-dimensional (3-D) organic network and holes along the 1-D lead-iodide nanowire. In this work, we theoretically study the electronic band-structure and photocarrier properties of MVPb2I6 by density functional theory (DFT) calculations. Our results clearly confirm the experimentally reported type-II band alignment, whose valence band mainly consists of 5p (I) orbitals of the lead-iodide nanowires and the conduction band of the lowest unoccupied molecular orbital of MV(2+). The DFT calculation also reveals weak charge-transfer interactions between the lead-iodide nanowires and MV(2+). In addition, the electronic distributions of the valence and conduction bands indicate the 3-D transport of electrons and 1-D transport of holes, supporting the reported experimental result. PMID:25050419

  11. Proteins from Avastin® (bevacizumab) show tyrosine nitrations for which the consequences are completely unclear.

    Science.gov (United States)

    Wan, Jia; Csaszar, Edina; Chen, Wei-Qiang; Li, Kongzhao; Lubec, Gert

    2012-01-01

    Avastin® (bevacizumab) is a protein drug widely used for cancer treatment although its further use is questionable due to serious side effects reported. As no systematic proteomic study on posttranslational modifications (PTMs) was reported so far, it was the aim of the current study to use a gel-based proteomics method for determination of Avastin®-protein(s). Avastin® was run on two-dimensional gel electrophoresis (2-DE), spots were picked, followed by multi-enzyme in-gel digestion. Subsequently, the resulting peptides and posttranslational modifications were identified by mass spectrometry (nano-LC-ESI-MS/MS; HCT and LTQ Orbitrap MS). Heavy and light chains were observed and the 9 spots that were picked from 2DE-gels were identified as bevacizumab with high sequence coverage. MS/MS results showed multiple tyrosine nitrations on the Avastin® light and heavy chains that were either represented as nitrotyrosine or as aminotyrosine, which was shown to be generated from nitrotyrosine under reducing conditions. Protein nitration is known to significantly change protein functions and interactions and it may well be that some of the adverse effects of the protein drug Avastin® may be due to this PTM, which may have been generated during production--thus, nitration of Avastin® is a challenge for the pharmaceutical industry. PMID:22523550

  12. HFE H63D mutation frequency shows an increase in Turkish women with breast cancer

    Directory of Open Access Journals (Sweden)

    Guler Emine

    2006-02-01

    Full Text Available Abstract Background The hereditary hemochromatosis gene HFE plays a pivotal role in iron homeostasis. The association between cancer and HFE hetero- or homozygosity has previously been shown including hepatocellular and nonhepatocellular malignancies. This study was performed to compare frequencies of HFE C282Y and H63D variants in Turkish women with breast cancer and healthy controls. Methods Archived DNA samples of Hacettepe University Oncology Institute were used in this study. The HFE gene was investigated by PCR-RFLP. Results All subjects studied were free from C282Y mutation. Thirty-nine patients had H63D mutation and were all heterozygous. H63D allele frequency was 22.2% (39/176 in the breast cancer patients, and 14% (28/200 in the healthy volunteers. Statistical analysis of cases with HFE H63D phenotype showed significant difference between breast cancer and healthy volunteers (P = 0.02. Conclusion Our results suggest that HFE H63D mutation frequencies were increased in the breast cancer patients in comparison to those in the general population. Also, odds ratios (odds ratio = 2.05 computed in this study suggest that H63D has a positive association with breast cancer.

  13. Populations of Monarch butterflies with different migratory behaviors show divergence in wing morphology.

    Science.gov (United States)

    Altizer, Sonia; Davis, Andrew K

    2010-04-01

    The demands of long-distance flight represent an important evolutionary force operating on the traits of migratory species. Monarchs are widespread butterflies known for their annual migrations in North America. We examined divergence in wing morphology among migratory monarchs from eastern and western N. America, and nonmigratory monarchs in S. Florida, Puerto Rico, Costa Rica, and Hawaii. For the three N. American populations, we also examined monarchs reared in four common environment experiments. We used image analysis to measure multiple traits including forewing area and aspect ratio; for laboratory-reared monarchs we also quantified body area and wing loading. Results showed wild monarchs from all nonmigratory populations were smaller than those from migratory populations. Wild and captive-reared eastern monarchs had the largest and most elongated forewings, whereas monarchs from Puerto Rico and Costa Rica had the smallest and roundest forewings. Eastern monarchs also had the largest bodies and high measures of wing loading, whereas western and S. Florida monarchs had less elongated forewings and smaller bodies. Among captive-reared butterflies, family-level effects provided evidence that genetic factors contributed to variation in wing traits. Collectively, these results support evolutionary responses to long-distance flight in monarchs, with implications for the conservation of phenotypically distinct wild populations. PMID:20067519

  14. Characterization of indium-tin oxide sputtering targets showing various densities of nodule formation

    International Nuclear Information System (INIS)

    Eight Sn-doped In2O3 (ITO) target materials for direct-current (DC) magnetron sputtering, showing various rates of nodule formation, were subjected to analyses of lattice parameter, relative density, electrical properties, optical absorption spectra in 0.5-5 eV and oxygen deficiency, ?, in (In0.905Sn0.095)2O3+x-?. The ? value was evaluated by heating the sample powders in a closed-system oxygen analyzer involving a solid electrolyte and analyzing their oxygen uptake rate from the Ar + O2 circulating gas. The oxygen uptake by the powders started at approximately 623 K, and the successive oxygen release took place at higher temperatures than 823 K. For each sample, the lattice parameter monotonically decreased with the amount of oxygen absorbed, much like energy absorption maximum at approximately 1 eV. Among all the samples, energy absorption maximum at approximately 1 eV decreased linearly with decreasing conduction electron density, n. The correlations of ? with conduction electron density and relative density were not good, compared with that with lattice parameter. These results have implied that, for the samples with relative density higher than 99.5%, locally inhomogeneous conduction electron density, due to local deviation from the uniform distributions of tin ion and oxygen vacancy, increased the rate of nodule formation. A convenient manner for detecting the target quality has beer detecting the target quality has been suggested based on the experimental results

  15. Metabolic remodeling agents show beneficial effects in the dystrophin-deficient mdx mouse model

    Directory of Open Access Journals (Sweden)

    Jahnke Vanessa E

    2012-08-01

    Full Text Available Abstract Background Duchenne muscular dystrophy is a genetic disease involving a severe muscle wasting that is characterized by cycles of muscle degeneration/regeneration and culminates in early death in affected boys. Mitochondria are presumed to be involved in the regulation of myoblast proliferation/differentiation; enhancing mitochondrial activity with exercise mimetics (AMPK and PPAR-delta agonists increases muscle function and inhibits muscle wasting in healthy mice. We therefore asked whether metabolic remodeling agents that increase mitochondrial activity would improve muscle function in mdx mice. Methods Twelve-week-old mdx mice were treated with two different metabolic remodeling agents (GW501516 and AICAR, separately or in combination, for 4 weeks. Extensive systematic behavioral, functional, histological, biochemical, and molecular tests were conducted to assess the drug(s' effects. Results We found a gain in body and muscle weight in all treated mice. Histologic examination showed a decrease in muscle inflammation and in the number of fibers with central nuclei and an increase in fibers with peripheral nuclei, with significantly fewer activated satellite cells and regenerating fibers. Together with an inhibition of FoXO1 signaling, these results indicated that the treatments reduced ongoing muscle damage. Conclusions The three treatments produced significant improvements in disease phenotype, including an increase in overall behavioral activity and significant gains in forelimb and hind limb strength. Our findings suggest that triggering mitochondrial activity with exercise mimetics improves muscle function in dystrophin-deficient mdx mice.

  16. Genetic connections between dressage and show-jumping horses in Dutch Warmblood horses

    DEFF Research Database (Denmark)

    Rovere, Gabriel; Madsen, Per

    2014-01-01

    During the last decades, the breeding practice within the Dutch Warmblood studbook (KWPN) has resulted in an increasing specialisation of horses into show-jumping (JH) and dressage (DH). The objective of this study was to describe the effect of the specialisation on the connectedness between the subpopulations of JH and DH horses registered by KWPN. The subpopulations comprised 23,800 JH horses and 18,125 DH horses, born between 1995 and 2009. Genetic similarity (GS), genetic pool in common (GCx) based on the marginal genetic contribution of common ancestors and coefficient of relationship (r) between and within subpopulations were analysed in three periods of time to describe changes in genetic connectedness between subpopulations. A decline in GS (0.97–0.45), GC0.5 (0.69–0.13) and r (0.018–0.014) in the recent years was observed. Both subpopulations have a common genetic pool; however, if the specialisation process continues, it will result in two unrelated (genetic) groups.

  17. Push in South of the Hellas Basin Showing Topography from MOLA: New Color Map

    Science.gov (United States)

    Tom Biddlecome

    1999-11-22

    Zoom into the region of Mars just south of the Hellas Basin showing topography data from MOLA. This animation uses a color table designed to highlight the topography at the south pole. White colors indicate elevations in excess of 3012 meters, red shows elevations between 2500 and 3012 meters, yellow shows elevations from 2450 to 2500 meters, dark cyan shows elevations from 2150 to 2450 meters, dark violet shows elevations from 320 to 2150 meters.

  18. Pressure locking test results

    Energy Technology Data Exchange (ETDEWEB)

    DeWall, K.G.; Watkins, J.C.; McKellar, M.G.; Bramwell, D. [Idaho National Engineering Lab., Idaho Falls, ID (United States)] [and others

    1996-12-01

    The U.S. Nuclear Regulatory Commission (NRC), Office of Nuclear Regulatory Research, is funding the Idaho National Engineering Laboratory (INEL) in performing research to provide technical input for their use in evaluating responses to Generic Letter 95-07, {open_quotes}Pressure Locking and Thermal Binding of Safety-Related Power-Operated Gate Valves.{close_quotes} Pressure locking and thermal binding are phenomena that make a closed gate valve difficult to open. This paper discusses only the pressure locking phenomenon in a flexible-wedge gate valve; the authors will publish the results of their thermal binding research at a later date. Pressure locking can occur when operating sequences or temperature changes cause the pressure of the fluid in the bonnet (and, in most valves, between the discs) to be higher than the pressure on the upstream and downstream sides of the disc assembly. This high fluid pressure presses the discs against both seats, making the disc assembly harder to unseat than anticipated by the typical design calculations, which generally consider friction at only one of the two disc/seat interfaces. The high pressure of the bonnet fluid also changes the pressure distribution around the disc in a way that can further contribute to the unseating load. If the combined loads associated with pressure locking are very high, the actuator might not have the capacity to open the valve. The results of the NRC/INEL research discussed in this paper show that the relationship between bonnet pressure and pressure locking stem loads appears linear. The results also show that for this valve, seat leakage affects the bonnet pressurization rate when the valve is subjected to thermally induced pressure locking conditions.

  19. Perception And Preferences Of People Regarding Reality Shows – A Study In Navsari City Of Gujarat

    Directory of Open Access Journals (Sweden)

    Zakirhusen Patel

    2013-12-01

    Full Text Available The rising popularity of the reality shows on Indian television has added a new dimension to the production of TV programs. Most of the television shows which are being telecast nowadays are reality shows specializing in dancing, singing, and acting. Today's reality shows are rewriting our cultural scripts, altering our perception, our social relationships and our relationships to the natural world. In this descriptive study, the researcher has found that people are really fond of watching reality shows which range from cookery to talent hunt and comedy show types. Majority of the respondents, however, felt that these types of shows are often scripted for increasing TRPs and increasing financial and commercial success. Major drivers for watching reality shows are break from routine, controversies, glamour and entertainment. However, most of the people were not still holding any views whether such types of reality shows make any sort of impact on the society.

  20. Shuttle Risk Progression: Use of the Shuttle Probabilistic Risk Assessment (PRA) to Show Reliability Growth

    Science.gov (United States)

    Hamlin, Teri L.

    2011-01-01

    It is important to the Space Shuttle Program (SSP), as well as future manned spaceflight programs, to understand the early mission risk and progression of risk as the program gains insights into the integrated vehicle through flight. The risk progression is important to the SSP as part of the documentation of lessons learned. The risk progression is important to future programs to understand reliability growth and the first flight risk. This analysis uses the knowledge gained from 30 years of operational flights and the current Shuttle PRA to calculate the risk of Loss of Crew and Vehicle (LOCV) at significant milestones beginning with the first flight. Key flights were evaluated based upon historical events and significant re-designs. The results indicated that the Shuttle risk tends to follow a step function as opposed to following a traditional reliability growth pattern where risk exponentially improves with each flight. In addition, it shows that risk can increase due to trading safety margin for increased performance or due to external events. Due to the risk drivers not being addressed, the risk did not improve appreciably during the first 25 flights. It was only after significant events occurred such as Challenger and Columbia, where the risk drivers were apparent, that risk was significantly improved. In addition, this paper will show that the SSP has reduced the risk of LOCV by almost an order of magnitude. It is easy to look back afte r 30 years and point to risks that are now obvious, however; the key is to use this knowledge to benefit other programs which are in their infancy stages. One lesson learned from the SSP is understanding risk drivers are essential in order to considerably reduce risk. This will enable the new program to focus time and resources on identifying and reducing the significant risks. A comprehensive PRA, similar to that of the Shuttle PRA, is an effective tool quantifying risk drivers if support from all of the stakeholders is given.

  1. Both right- and left-handers show a bias to attend others' right arm.

    Science.gov (United States)

    Marzoli, Daniele; Lucafò, Chiara; Pagliara, Alessandra; Cappuccio, Romina; Brancucci, Alfredo; Tommasi, Luca

    2015-02-01

    The common-coding hypothesis suggests that the more similar an observed action is to the way the observer would perform it, the stronger is the ensuing activation of motor representations. Therefore, producing actions could prime perception so that observers would be particularly responsive to (i.e. biased to perceive) actions that are related to, and share features with, their own actions. If this similarity principle also applies to handedness, right- and left-handers should be more likely to perceive actions as performed with their dominant rather than non-dominant hand. In two experiments, participants were required to indicate the perceived orientation (front or back view) of pictures of ambiguous human silhouettes performing one-handed manual actions. Experiment 1, in which 300 right-handers and 60 left-handers reported the orientation of a single silhouette seen for as much as they wished, showed that participants perceived the figures more frequently in an orientation congruent with a movement performed with the right rather than the left hand. Experiment 2, in which 12 right-handers and 12 left-handers reported the orientation of 52 silhouettes seen for 300 ms, showed similar results when multiple responses per participant were collected rather than only one. Contrary to our expectations, no difference was observed between right- and left-handers, which might suggest an attentional bias towards the right arm of human bodies in both groups. Moreover, participants were more likely to perceive the figure as front-facing than as back-facing, possibly due to the greater adaptive relevance of approaching compared to receding individuals. PMID:25318614

  2. Mannosylerythritol lipid, a yeast extracellular glycolipid, shows high binding affinity towards human immunoglobulin G

    Directory of Open Access Journals (Sweden)

    Ikegami Toru

    2001-09-01

    Full Text Available Abstract Background There have been many attempts to develop new materials with stability and high affinity towards immunoglobulins. Some of glycolipids such as gangliosides exhibit a high affinity toward immunoglobulins. However, it is considerably difficult to develop these glycolipids into the practical separation ligand due to their limited amounts. We thus focused our attention on the feasible use of "mannosylerythritol lipid A", a yeast glycolipid biosurfactant, as an alternative ligand for immunoglobulins, and undertook the investigation on the binding between mannosylerythritol lipid A (MEL-A and human immunoglobulin G (HIgG. Results In ELISA assay, MEL-A showed nearly the same binding affinity towards HIgG as that of bovine ganglioside GM1. Fab of human IgG was considered to play a more important role than Fc in the binding of HIgG by MEL-A. The bound amount of HIgG increased depending on the attached amount of MEL-A onto poly (2-hydroxyethyl methacrylate (polyHEMA beads, whereas the amount of human serum albumin slightly decreased. Binding-amount and -selectivity of HIgG towards MEL-A were influenced by salt species, salt concentration and pH in the buffer solution. The composite of MEL-A and polyHEMA, exhibited a significant binding constant of 1.43 × 106 (M-1 for HIgG, which is approximately 4-fold greater than that of protein A reported. Conclusions MEL-A shows high binding-affinity towards HIgG, and this is considered to be due to "multivalent effect" based on the binding molar ratio. This is the first report on the binding of a natural human antibody towards a yeast glycolipid.

  3. Airway wall thickening and emphysema show independent familial aggregation in chronic obstructive pulmonary disease.

    DEFF Research Database (Denmark)

    Patel, Bipen D; Coxson, Harvey O

    2008-01-01

    RATIONALE: It is unclear whether airway wall thickening and emphysema make independent contributions to airflow limitation in chronic obstructive pulmonary disease (COPD) and whether these phenotypes cluster within families. OBJECTIVES: To determine whether airway wall thickening and emphysema (1) make independent contributions to the severity of COPD and (2) show independent aggregation in families of individuals with COPD. METHODS: Index cases with COPD and their smoking siblings underwent spirometry and were offered high-resolution computed tomography scans of the thorax to assess the severity of airway wall thickening and emphysema. MEASUREMENTS AND MAIN RESULTS: A total of 3,096 individuals were recruited to the study, of whom 1,159 (519 probands and 640 siblings) had technically adequate high-resolution computed tomography scans without significant non-COPD-related thoracic disease. Airway wall thickness correlated with pack-years smoked (P < or = 0.001) and symptoms of chronic bronchitis (P < 0.001). FEV(1) (expressed as % predicted) was independently associated with airway wall thickness at a lumen perimeter of 10 mm (P = 0.0001) and 20 mm (P = 0.0013) and emphysema at -950 Hounsfield units (P < 0.0001). There was independent familial aggregation of both the emphysema (adjusted odds ratio, 2.1; 95% confidence interval, 1.1-4.0; P < or = 0.02) and airway disease phenotypes (P < 0.0001) of COPD. CONCLUSIONS: Airway wall thickening and emphysema make independent contributions to airflow obstruction in COPD. These phenotypes show independent aggregation within families of individuals with COPD, suggesting that different genetic factors influence these disease processes.

  4. Narcoleptic Patients Show Fragmented EEG-Microstructure During Early NREM Sleep.

    Science.gov (United States)

    Kuhn, Alena; Brodbeck, Verena; Tagliazucchi, Enzo; Morzelewski, Astrid; von Wegner, Frederic; Laufs, Helmut

    2015-07-01

    Narcolepsy is a chronic disorder of the sleep-wake cycle with pathological shifts between sleep stages. These abrupt shifts are induced by a sleep-regulating flip-flop mechanism which is destabilized in narcolepsy without obvious alterations in EEG oscillations. Here, we focus on the question whether the pathology of narcolepsy is reflected in EEG microstate patterns. 30 channel awake and NREM sleep EEGs of 12 narcoleptic patients and 32 healthy subjects were analyzed. Fitting back the dominant amplitude topography maps into the EEG led to a temporal sequence of maps. Mean microstate duration, ratio total time (RTT), global explained variance (GEV) and transition probability of each map were compared between both groups. Nine patients reached N1, 5 N2 and only 4 N3. All healthy subjects reached at least N2, 19 also N3. Four dominant maps could be found during wakefulness and all NREM- sleep stages in healthy subjects. During N3, narcolepsy patients showed an additional fifth map. The mean microstate duration was significantly shorter in narcoleptic patients than controls, most prominent in deep sleep. Single maps' GEV and RTT were also altered in narcolepsy. Being aware of the limitation of our low sample size, narcolepsy patients showed wake-like features during sleep as reflected in shorter microstate durations. These microstructural EEG alterations might reflect the intrusion of brain states characteristic of wakefulness into sleep and an instability of the sleep-regulating flip-flop mechanism resulting not only in pathological switches between REM- and NREM-sleep but also within NREM sleep itself, which may lead to a microstructural fragmentation of the EEG. PMID:25168255

  5. De novo sequencing and characterization of Picrorhiza kurrooa transcriptome at two temperatures showed major transcriptome adjustments

    Directory of Open Access Journals (Sweden)

    Gahlan Parul

    2012-03-01

    Full Text Available Abstract Background Picrorhiza kurrooa Royle ex Benth. is an endangered plant species of medicinal importance. The medicinal property is attributed to monoterpenoids picroside I and II, which are modulated by temperature. The transcriptome information of this species is limited with the availability of few hundreds of expressed sequence tags (ESTs in the public databases. In order to gain insight into temperature mediated molecular changes, high throughput de novo transcriptome sequencing and analyses were carried out at 15°C and 25°C, the temperatures known to modulate picrosides content. Results Using paired-end (PE Illumina sequencing technology, a total of 20,593,412 and 44,229,272 PE reads were obtained after quality filtering for 15°C and 25°C, respectively. Available (e.g., De-Bruijn/Eulerian graph and in-house developed bioinformatics tools were used for assembly and annotation of transcriptome. A total of 74,336 assembled transcript sequences were obtained, with an average coverage of 76.6 and average length of 439.5. Guanine-cytosine (GC content was observed to be 44.6%, while the transcriptome exhibited abundance of trinucleotide simple sequence repeat (SSR; 45.63% markers. Large scale expression profiling through "read per exon kilobase per million (RPKM", showed changes in several biological processes and metabolic pathways including cytochrome P450s (CYPs, UDP-glycosyltransferases (UGTs and those associated with picrosides biosynthesis. RPKM data were validated by reverse transcriptase-polymerase chain reaction using a set of 19 genes, wherein 11 genes behaved in accordance with the two expression methods. Conclusions Study generated transcriptome of P. kurrooa at two different temperatures. Large scale expression profiling through RPKM showed major transcriptome changes in response to temperature reflecting alterations in major biological processes and metabolic pathways, and provided insight of GC content and SSR markers. Analysis also identified putative CYPs and UGTs that could help in discovering the hitherto unknown genes associated with picrosides biosynthesis.

  6. 123I-MIBG SPECT shows myocardial denervation after transmyocardial laser revascularisation

    International Nuclear Information System (INIS)

    Transmyocardial laser revascularization (TMLR) is an invasive therapy used to treat patients with severe refractory angina pectoris in whom standard treatment is insufficient or not possible. Randomized trials have reported a clear clinical benefit (relief of angina and improvement of Quality of Life (QOL)) of TMLR compared to maximal medical treatment. The post-TMLR clinical improvement has been suggested to be associated with myocardial sympathetic denervation. The aim of the present study was to investigate if TMLR induces myocardial sympathetic denervation. TMLR was performed in 8 patients with refractory angina pectoris. Pre- and post-TMLR myocardial perfusion scintigraphy (99mTc-Tetrofosmin SPECT) and sympathetic innervation (123I-MIBG SPECT) were semi-quantitatively assessed using an 18 segment model and a 5 point scoring system. Pre- and post-TMLR summed perfusion, denervation and difference scores were calculated. In all patients post-TMLR 123I-MIBG SPECT showed decreased uptake: summed denervation score pre-TMLR was 13.4±3.9 vs. 23.9±4.3 post-TMLR (P=0.00002). In 80% of segments the decreased uptake could be related to the TMLR treated area. Pre- and post TMLR myocardial perfusion scintigraphy did not show significant differences. In all patients angina reduced by ? 2 classes (NYHA classification) at 3 to 12 months follow up, and QOL significantly improved. Our results indicate that TMLR-induced improvement of angina and MLR-induced improvement of angina and QOL can be explained by destruction of nociceptors or cardiac neural pathways, changing the perception of anginal pain

  7. Synonymous codon usage bias is correlative to intron number and shows disequilibrium among exons in plants

    Directory of Open Access Journals (Sweden)

    Qin Zhen

    2013-01-01

    Full Text Available Abstract Background Evidence has been assembled to suggest synonymous codon usage bias (SCUB has close relationship with intron. However, the relationship (if any between SCUB and intron number as well as exon position is at present rather unclear. Results To explore this relationship, the sequences of a set of genes containing between zero and nine introns was extracted from the published genome sequences of three algal species, one moss, one fern and six angiosperms (three monocotyledonous species and three dicotyledonous species. In the algal genomes, the frequency of synonymous codons of the form NNG/NNC (codons with G and C at the third position was positively related to intron number, but that of NNA/NNT was inversely correlated; the opposite was the case in the land plant genomes. The frequency of NNC/NNG was higher and that of NNA/NNT lower in two terminal exons than in the interstitial exons in the land plant genes, but the rule showed to be opposite in the algal genes. SCUB patterns in the interstitial and two terminal exons mirror the different evolutionary relationships between these plant species, while the first exon shows the highest level of conservation is therefore concluded to be the one which experiences the heaviest selection pressure. The phenomenon of SCUB may also be related to DNA methylation induced conversion of CG to AT. Conclusions These data provide some evidence of linkage between SCUB, the evolution of introns and DNA methylation, which brings about a new perspective for understanding how genomic variation is created during plant evolution.

  8. Porn video shows, local brew, and transactional sex: HIV risk among youth in Kisumu, Kenya

    Directory of Open Access Journals (Sweden)

    Voeten Helene ACM

    2011-08-01

    Full Text Available Abstract Background Kisumu has shown a rising HIV prevalence over the past sentinel surveillance surveys, and most new infections are occurring among youth. We conducted a qualitative study to explore risk situations that can explain the high HIV prevalence among youth in Kisumu town, Kenya Methods We conducted in-depth interviews with 150 adolescents aged 15 to 20, held 4 focus group discussions, and made 48 observations at places where youth spend their free time. Results Porn video shows and local brew dens were identified as popular events where unprotected multipartner, concurrent, coerced and transactional sex occurs between adolescents. Video halls - rooms with a TV and VCR - often show pornography at night for a very small fee, and minors are allowed. Forced sex, gang rape and multiple concurrent relationships characterised the sexual encounters of youth, frequently facilitated by the abuse of alcohol, which is available for minors at low cost in local brew dens. For many sexually active girls, their vulnerability to STI/HIV infection is enhanced due to financial inequality, gender-related power difference and cultural norms. The desire for love and sexual pleasure also contributed to their multiple concurrent partnerships. A substantial number of girls and young women engaged in transactional sex, often with much older working partners. These partners had a stronger socio-economic position than young women, enabling them to use money/gifts as leverage for sex. Condom use was irregular during all types of sexual encounters. Conclusions In Kisumu, local brew dens and porn video halls facilitate risky sexual encounters between youth. These places should be regulated and monitored by the government. Our study strongly points to female vulnerabilities and the role of men in perpetuating the local epidemic. Young men should be targeted in prevention activities, to change their attitudes related to power and control in relationships. Girls should be empowered how to negotiate safe sex, and their poverty should be addressed through income-generating activities.

  9. 77 FR 43517 - Safety Zone; Flying Magazine Air Show, Lake Winnebago, Oshkosh, WI

    Science.gov (United States)

    2012-07-25

    ...associated with an air show and associated pyrotechnics, which are discussed further below...2012, an air show with associated pyrotechnics will be held over Lake Winnebago in...acrobatic maneuvers with associated pyrotechnics proximate to a gathering of...

  10. 27 CFR 30.62 - Table 2, showing wine gallons and proof gallons by weight.

    Science.gov (United States)

    2010-04-01

    ... 2010-04-01 false Table 2, showing wine gallons and proof gallons by weight. 30...Prescribed Tables § 30.62 Table 2, showing wine gallons and proof gallons by weight. The wine and proof gallon content by weight...

  11. Targeting Gene-Viro-Therapy with AFP driving Apoptin gene shows potent antitumor effect in hepatocarcinoma

    Directory of Open Access Journals (Sweden)

    Zhang Kang-Jian

    2012-02-01

    Full Text Available Abstract Background Gene therapy and viral therapy are used for cancer therapy for many years, but the results are less than satisfactory. Our aim was to construct a new recombinant adenovirus which is more efficient to kill hepatocarcinoma cells but more safe to normal cells. Methods By using the Cancer Targeting Gene-Viro-Therapy strategy, Apoptin, a promising cancer therapeutic gene was inserted into the double-regulated oncolytic adenovirus AD55 in which E1A gene was driven by alpha fetoprotein promoter along with a 55 kDa deletion in E1B gene to form AD55-Apoptin. The anti-tumor effects and safety were examined by western blotting, virus yield assay, real time polymerase chain reaction, 3-(4,5-dimethylthiazol-2-yl-2, 5-diphenyltetrazolium bromide assay, Hoechst33342 staining, Fluorescence-activated cell sorting, xenograft tumor model, Immunohistochemical assay, liver function analysis and Terminal deoxynucleotidyl transferase mediated dUTP Nick End Labeling assay. Results The recombinant virus AD55-Apoptin has more significant antitumor effect for hepatocelluar carcinoma cell lines (in vitro than that of AD55 and even ONYX-015 but no or little impair on normal cell lines. Furthermore, it also shows an obvious in vivo antitumor effect on the Huh-7 liver carcinoma xenograft in nude mice with bigger beginning tumor volume till about 425 mm3 but has no any damage on the function of liver. The induction of apoptosis is involved in AD55-Apoptin induced antitumor effects. Conclusion The AD55-Apoptin can be a potential anti-hepatoma agent with remarkable antitumor efficacy as well as higher safety in cancer targeting gene-viro-therapy system.

  12. Male carriers of the FMR1 premutation show altered hippocampal-prefrontal function during memory encoding

    Directory of Open Access Journals (Sweden)

    JohnMWang

    2012-10-01

    Full Text Available Previous functional MRI (fMRI studies have shown that fragile X mental retardation 1 (FMR1 premutation allele carriers (FXPCs exhibit decreased hippocampal activation during a recall task and lower inferior frontal activation during a working memory task compared to matched controls. The molecular characteristics of FXPCs includes 55 to 200 CGG trinucleoutide expansions, increased FMR1 mRNA levels, and decreased FMRP levels especially at higher repeat sizes. In the current study, we utilized MRI to examine differences in hippocampal volume and function during an encoding task in young male FXPCs. While no decreases in either hippocampal volume or hippocampal activity were observed during the encoding task in FXPCs, FMRP level (measured in blood correlated with decreases in parahippocampal activation. In addition, activity in the right dorsolateral prefrontal cortex during correctly encoded trials correlated negatively with mRNA levels. These results, as well as the established biological effects associated with elevated mRNA levels and decreased FMRP levels on dendritic maturation and axonal growth, prompted us to explore functional connectivity between the hippocampus, prefrontal cortex, and parahippocampal gyrus using a psychophysiological interaction analysis. In FXPCs, the right hippocampus evinced significantly lower connectivity with right ventrolateral prefrontal cortex (VLPFC and right parahippocampal gyrus. Furthermore, the weaker connectivity between the right hippocampus and VLPFC was associated with reduced FMRP in the FXPC group. These results suggest that while FXPCs show relatively typical brain response during encoding, faulty connectivity between frontal and hippocampal regions may have subsequent effects on recall and working memory.

  13. 77 FR 40798 - Safety Zone; Nautical City Festival Air Show, Rogers City MI

    Science.gov (United States)

    2012-07-11

    ...Zone; Nautical City Festival Air Show, Rogers City MI AGENCY: Coast Guard, DHS. ACTION...Zone; Nautical City Festival Air Show, Rogers City MI; in the Federal Register (77...show will be launched to the east of the Rogers City marina. The Captain of the...

  14. 77 FR 29932 - Safety Zone; Nautical City Festival Air Show, Rogers City, MI

    Science.gov (United States)

    2012-05-21

    ...Zone; Nautical City Festival Air Show, Rogers City, MI AGENCY: Coast Guard, DHS...show will be launched to the east of the Rogers City marina. The Captain of the Port...the Nautical City Festival air show near Rogers City, MI, the Captain of the Port...

  15. 76 FR 2000 - Modification of Class E Airspace; Show Low, AZ

    Science.gov (United States)

    2011-01-12

    ...10-AWP-16] Modification of Class E Airspace...700 feet above the surface, at Show Low Regional...700 feet above the surface within a 6.7-mile...the 038[deg] bearing of the Show Low...the 085[deg] bearing of the Show Low...200 feet above the surface within an area...

  16. Dating of processes in karst and caves implication for show caves prezentation.

    Czech Academy of Sciences Publication Activity Database

    Bosák, Pavel

    Liptovský Mikulᚠ: International Show Caves Association, 2011 - (Bella, P.; Gažík, P.), s. 34-41 ISBN 978-80-89310-59-3. [Congress International Show Caves Association /6./. Demänovská Valley (SK), 18.10.2010-23.10.2010] Institutional research plan: CEZ:AV0Z30130516 Keywords : karst * speleogenesis * karst sediments * dating methods * geochronology * show caves Subject RIV: DB - Geology ; Mineralogy

  17. Two cytosolic aldolases show different expression patterns during shoot elongation in Moso bamboo, Phyllostachys pubescens Mazel.

    Science.gov (United States)

    Lao, Xintian; Azuma, Jun-ichi; Sakamoto, Masahiro

    2013-11-01

    In fast-growing Moso bamboo (Phyllostachys pubescens Mazel), cytosolic fructose 1,6-bisphosphate aldolase (aldolase; EC 4.2.2.13) was more highly active in elongating tissues than in tissues that had already finished elongating. It is well known that the removal of the culm sheath prevents bamboo from elongating. When the sheath was removed from the culm, the aldolase activity was gradually reduced over time. Two isozyme genes for aldolase, PpAldC1 and PpAldC2, were cloned from the elongating tissues of Moso bamboo. Gene expression analysis using a semi-quantitative reverse transcriptase-polymerase chain reaction revealed that PpAldC1 was highly expressed in elongating tissues but was hardly detected in elongated internodes, while PpAldC2 seemed to be expressed constitutively in both elongating and elongated tissues. Promoter analysis revealed that the expression of PpAldC1 was induced by gibberellin. These results indicated that the two genes for cytosolic aldolase in Moso bamboo showed different expression patterns and that one of them was involved in shoot elongation. PMID:23517182

  18. Detection of chromosomal regions showing differential gene expression in human skeletal muscle and in alveolar rhabdomyosarcoma

    Directory of Open Access Journals (Sweden)

    Bortoluzzi Stefania

    2004-06-01

    Full Text Available Abstract Background Rhabdomyosarcoma is a relatively common tumour of the soft tissue, probably due to regulatory disruption of growth and differentiation of skeletal muscle stem cells. Identification of genes differentially expressed in normal skeletal muscle and in rhabdomyosarcoma may help in understanding mechanisms of tumour development, in discovering diagnostic and prognostic markers and in identifying novel targets for drug therapy. Results A Perl-code web client was developed to automatically obtain genome map positions of large sets of genes. The software, based on automatic search on Human Genome Browser by sequence alignment, only requires availability of a single transcribed sequence for each gene. In this way, we obtained tissue-specific chromosomal maps of genes expressed in rhabdomyosarcoma or skeletal muscle. Subsequently, Perl software was developed to calculate gene density along chromosomes, by using a sliding window. Thirty-three chromosomal regions harbouring genes mostly expressed in rhabdomyosarcoma were identified. Similarly, 48 chromosomal regions were detected including genes possibly related to function of differentiated skeletal muscle, but silenced in rhabdomyosarcoma. Conclusion In this study we developed a method and the associated software for the comparative analysis of genomic expression in tissues and we identified chromosomal segments showing differential gene expression in human skeletal muscle and in alveolar rhabdomyosarcoma, appearing as candidate regions for harbouring genes involved in origin of alveolar rhabdomyosarcoma representing possible targets for drug treatment and/or development of tumor markers.

  19. Boehmenan, a lignan from Hibiscus ficulneus, showed Wnt signal inhibitory activity.

    Science.gov (United States)

    Shono, Takumi; Ishikawa, Naoki; Toume, Kazufumi; Arai, Midori A; Ahmed, Firoj; Sadhu, Samir K; Ishibashi, Masami

    2015-07-15

    The Wnt signal pathway modulates numerous biological processes, and its aberrant activation is related to various diseases. Therefore, inhibition of the Wnt signal may provide an effective (or efficient) strategy for these diseases. Cell-based luciferase assay targeting the Wnt signal (TOP assay) revealed that Hibiscus ficulneus extract inhibited the Wnt signal. The activity-guided isolation of the MeOH extract of H. ficulneus stems yielded four known (1-4) lignans along with myriceric acid (5). Compounds 1-4 potently inhibited the Wnt signal with TOPflash IC50 values of 1.0, 4.5, 6.3, and 1.9?M, respectively. Compound 1 exhibited cytotoxicity against both Wnt-dependent (HCT116) and Wnt-independent (RKO) cells. Western blot analysis showed that 1 decreased the expression of full, cytosolic and nuclear ?-catenin along with c-myc in STF/293 cells. Our results suggested that 1 may have inhibited the Wnt signal by decreasing ?-catenin levels. PMID:26026364

  20. Analysis of experimental evidence that shows adverse effects of salt and its relation to hypertension

    Directory of Open Access Journals (Sweden)

    Ignacio Bravo A.

    2012-02-01

    Full Text Available The study by Taylor et al published in June 2010 in the American Journal of Hypertension questions the effectiveness of reducing salt intake in the diet in the prevention and treatment of high blood pressure and other cardiovascular conditions. The publication of this article has lead to great controversy and medical associations and learned societies responded promptly. The response criticized the results of the meta-analysis and pointed out its methodological shortcomings. In this review we critically appraise the experimental evidence that shows the importance of diet salt intake and its role as a determinant of blood pressure. We briefly describe the paradigm that explains the role of salt intake in contributing in the regulation of blood pressure (Guyton hypothesis and model and we mention the experimental evidence that supports this. We briefly comment on the classical studies that indicate that salt intake (NaCl contributes directly to the development of high blood pressure and target tissues. Finally, we briefly mention the experimental data that is related with the controversy on the role of salt (NaCl or sodium as prohypertensive agents.

  1. Do humans show velocity-storage in the vertical rVOR?

    Science.gov (United States)

    Bertolini, G; Bockisch, C J; Straumann, D; Zee, D S; Ramat, S

    2008-01-01

    To investigate the contribution of the vestibular velocity-storage mechanism (VSM) to the vertical rotational vestibulo-ocular reflex (rVOR) we recorded eye movements evoked by off-vertical axis rotation (OVAR) using whole-body constant-velocity pitch rotations about an earth-horizontal, interaural axis in four healthy human subjects. Subjects were tumbled forward, and backward, at 60 deg/s for over 1 min using a 3D turntable. Slow-phase velocity (SPV) responses were similar to the horizontal responses elicited by OVAR along the body longitudinal axis, ('barbecue' rotation), with exponentially decaying amplitudes and a residual, otolith-driven sinusoidal response with a bias. The time constants of the vertical SPV ranged from 6 to 9 s. These values are closer to those that reflect the dynamic properties of vestibular afferents than the typical 20 s produced by the VSM in the horizontal plane, confirming the relatively smaller contribution of the VSM to these vertical responses. Our preliminary results also agree with the idea that the VSM velocity response aligns with the direction of gravity. The horizontal and torsional eye velocity traces were also sinusoidally modulated by the change in gravity, but showed no exponential decay. PMID:18718302

  2. Refolded scFv Antibody Fragment against Myoglobin Shows Rapid Reaction Kinetics

    Directory of Open Access Journals (Sweden)

    Hyung-Nam Song

    2014-12-01

    Full Text Available Myoglobin is one of the early biomarkers for acute myocardial infarction. Recently, we have screened an antibody with unique rapid reaction kinetics toward human myoglobin antigen. Antibodies with rapid reaction kinetics are thought to be an early IgG form produced during early stage of in vivo immunization. We produced a recombinant scFv fragment for the premature antibody from Escherichia coli using refolding technology. The scFv gene was constructed by connection of the VH–VL sequence with a (Gly4Ser3 linker. The scFv fragment without the pelB leader sequence was expressed at a high level, but the solubility was extremely low. A high concentration of 8 M urea was used for denaturation. The dilution refolding process in the presence of arginine and the redox reagents GSH and GSSH successfully produced a soluble scFv protein. The resultant refolded scFv protein showed association and dissociation values of 9.32 × 10?4 M?1·s?1 and 6.29 × 10?3 s?1, respectively, with an affinity value exceeding 107 M?1 (kon/koff, maintaining the original rapid reaction kinetics of the premature antibody. The refolded scFv could provide a platform for protein engineering for the clinical application for diagnosis of heart disease and the development of a continuous biosensor.

  3. Synthesis and biological evaluation of Esaprazole analogues showing ?1 binding and neuroprotective properties in vitro.

    Science.gov (United States)

    Kelly, Nicholas M; Wellejus, Anja; Elbrønd-Bek, Heidi; Weidner, Morten Sloth; Jørgensen, Signe Humle

    2013-06-01

    Esaprazole, a molecule previously acknowledged to protect against stomach and intestinal ulcers was surprisingly discovered to have neuroprotective activities and ?1 binding in vitro. A highly diverse set of Esaprazole analogues 2-5 was prepared in order to increase blood-brain barrier penetration. The analogues showed a structure-activity relationship at the ?1 receptor closely matching already published pharmacophores. Many of the analogues were shown to have neuroprotective properties in two assays using primary cultures of cortical neurons exposed to glutamate and hydrogen peroxide. However, no apparent SAR for these two assays could be developed. Metabolic stability of the analogues were also investigated and the structure of R(1) had a significant bearing on the ADME properties of the compound resulting in two series of compounds. Compounds in which R(1) was a H or acyl group had good metabolic stability in RLM but poor BBB penetration, whereas compounds where R(1) was a cyclo- or bicyclo-alkyl group had poor metabolic stability but good BBB penetration. PMID:23601816

  4. Crack/cocaine users show more family problems than other substance users

    Scientific Electronic Library Online (English)

    Helena Ferreira, Moura; Daniela, Benzano; Flavio, Pechansky; Felix Henrique Paim, Kessler.

    2014-07-01

    Full Text Available OBJECTIVES: To evaluate family problems among crack/cocaine users compared with alcohol and other substance users. METHODS: A cross-sectional multi-center study selected 741 current adult substance users from outpatient and inpatient Brazilian specialized clinics. Subjects were evaluated with the [...] sixth version of the Addiction Severity Index, and 293 crack users were compared with 126 cocaine snorters and 322 alcohol and other drug users. RESULTS: Cocaine users showed more family problems when compared with other drug users, with no significant difference between routes of administration. These problems included arguing (crack 66.5%, powder cocaine 63.3%, other drugs 50.3%, p?=?0.004), having trouble getting along with partners (61.5%×64.6%×48.7%, p?=?0.013), and the need for additional childcare services in order to attend treatment (13.3%×10.3%×5.1%, p?=?0.002). Additionally, the majority of crack/cocaine users had spent time with relatives in the last month (84.6%×86.5%×76.6%, p?=?0.011). CONCLUSIONS: Brazilian treatment programs should enhance family treatment strategies, and childcare services need to be included.

  5. Calcium imaging shows differential sensitivity to cooling and communication in luminous transgenic plants.

    Science.gov (United States)

    Campbell, A K; Trewavas, A J; Knight, M R

    1996-03-01

    Imaging of a recombinant bioluminescent Ca2+ indicator, aequorin, in an entire organism showed three novel features of Ca2+ signals in plants. First, cooling the plant from 25 degrees C to 2 degrees C demonstrated differential sensitivities between organs, the roots firing a Ca2+ signal at some 8-10 degrees C higher than the cotyledons. Secondly, prolonged cooling provoked Ca2+ oscillations, but only in the cotyledons. These oscillations occurred with a frequency of 100 s and damped down within 800 s. Thirdly, cooling the roots of mature plants triggered a Ca2+ signal in the leaves, as a result of organ-organ communication. However, warming and then recooling the roots did not generate a second Ca2+ signal in these leaves. This desensitisation was not due to down-regulation in the leaf since this was able to generate a Ca2+ signal of its own when cooled directly. Thus a combination of a recombinant bioluminescent indicator with photon counting imaging reveals startling new aspects of signalling in intact organs and whole organisms. PMID:8732261

  6. Pediatric Brainstem Gangliogliomas Show BRAFV600E Mutation in a High Percentage of Cases

    Science.gov (United States)

    Donson, Andrew M.; Kleinschmidt-DeMasters, B. K.; Aisner, Dara L.; Bemis, Lynne T.; Birks, Diane K.; Mulcahy Levy, Jean M.; Smith, Amy A.; Handler, Michael H.; Foreman, Nicholas K.; Rush, Sarah Z.

    2014-01-01

    Brainstem gangliogliomas (GGs) often cannot be resected, have a much poorer prognosis than those located in more common supratentorial sites, and may benefit from novel therapeutic approaches. Therapeutically-targetable BRAF c.1799T>A (p.V600E) (BRAFV600E) mutations are harbored in roughly 50% of collective GGs taken from all anatomical sites. Large numbers of pediatric brainstem GGs, however, have not been specifically assessed and anatomic- and age-restricted assessment of genetic and biological factors are becoming increasingly important. Pediatric brainstem GGs (n=13), non-brainstem GGs (n=11), and brainstem pilocytic astrocytomas (PAs) (n=8) were screened by standard Sanger DNA sequencing of BRAF exon 15. Five of 13 (38%) pediatric GG harbored a definitive BRAFV600E mutation, with 2 others exhibiting an equivocal result by this method. BRAFV600E was also seen in 5/11 (45%) non-brainstem GGs and 1/8 (13%) brainstem PAs. VE1 immunostaining for BRAFV600E showed concordance with sequencing in 9/9 brainstem GGs including the two cases equivocal by Sanger. The equivocal brainstem GGs were subsequently shown to harbor BRAFV600E using a novel, more sensitive, RNA-sequencing approach, yielding a final BRAFV600E mutation frequency of 54% (7/13) in brainstem GGs. BRAFV600E-targeted therapeutics should be a consideration for the high percentage of pediatric brainstem GGs refractory to conventional therapies. PMID:24238153

  7. Immune Neuroendocrine Phenotypes in Coturnix coturnix: Do Avian Species Show LEWIS/FISCHER-Like Profiles?

    Science.gov (United States)

    Nazar, F. Nicolas; Barrios, Bibiana E.; Kaiser, Pete; Marin, Raul H.; Correa, Silvia G.

    2015-01-01

    Immunoneuroendocrinology studies have identified conserved communicational paths in birds and mammals, e.g. the Hypothalamus-Pituitary-Adrenal axis with anti-inflammatory activity mediated by glucocorticoids. Immune neuroendocrine phenotypes (INPs) have been proposed for mammals implying the categorization of a population in subgroups underlying divergent immune-neuroendocrine interactions. These phenotypes were studied in the context of the LEWIS/FISCHER paradigm (rats expressing high or low pro-inflammatory profiles, respectively). Although avian species have some common immunological mechanisms with mammals, they have also evolved some distinct strategies and, until now, it has not been studied whether birds may also share with mammals similar INPs. Based on corticosterone levels we determined the existence of two divergent groups in Coturnix coturnix that also differed in other immune-neuroendocrine responses. Quail with lowest corticosterone showed higher lymphoproliferative and antibody responses, interferon-? and interleukin-1? mRNA expression levels and lower frequencies of leukocyte subpopulations distribution and interleukin-13 levels, than their higher corticosterone counterparts. Results suggest the existence of INPs in birds, comparable to mammalian LEWIS/FISCHER profiles, where basal corticosterone also underlies responses of comparable variables associated to the phenotypes. Concluding, INP may not be a mammalian distinct feature, leading to discuss whether these profiles represent a parallel phenomenon evolved in birds and mammals, or a common feature inherited from a reptilian ancestor millions of years ago. PMID:25793369

  8. Prostate cancer cells show elevated urokinase receptor in a mouse model of metastasis

    Directory of Open Access Journals (Sweden)

    Francis Joseph

    2006-08-01

    Full Text Available Abstract Background The urokinase receptor (uPAR governs several functions necessary during invasion and metastasis such as motility, degradation of the extracellular matrix and adhesion. This receptor has been recently associated with clinical prostate cancer progression. Experimentally, inhibition of uPAR reduces colonization of extra-prostatic sites in animal models. Our objective in this study was to compare uPAR expression in orthotopic vs. metastatic foci in vivo and to examine at the cellular level how uPAR might promote early stages of metastasis. Results We show that uPAR staining is significantly greater in regional lymph node metastases than in the intraprostatic tumor mass. Using transient over-expression, we found that uPAR increases in vitro motility and chemotactic invasion. Finally, we demonstrate that uPAR is up-regulated by a significant subpopulation prostate cancer cells following matrix detachment and maintenance in suspension and we provide evidence that prostate cancer cells with elevations in uPAR have an enhanced resistance to anoikis. Conclusion These data provide new evidence that uPAR can be induced by cancer cells during metastasis in vivo and that this elevated uPAR enhances resistance to anoikis in vitro.

  9. Chin Shan analyses show advantages of whole pool multi-rack approach

    International Nuclear Information System (INIS)

    Nuclear fuel storage racks are essentially thin-walled, cellular structures of prismatic cross-section. Although the details of design vary from one supplier to another, certain key physical attributes are common to all designs. For example, all racks feature square cells of sufficient opening size and height to enable insertion and withdrawal of the fuel assembly. The array of cells is positioned in a vertical orientation and is supported off the pool slab surface by four or more support legs. The spent fuel pool is filled with the individual fuel racks. The plenum created by the support legs is essential for proper cooling of the fuel assemblies stored in the rack, which relies on natural convective cooling to extract the heat emitted by the spent fuel. However, it has the insalutary effect of making it kinematically less stable. Regulatory authorities require careful and comprehensive analysis of the response of the racks under the seismic motions postulated for the pool slab. Results from whole pool multi-rack (WPMR) analyses at the Chin Shan and Oyster Creek nuclear plants point up the potential inadequacies of single rack 3D analyses, and show just how important it is to carry out WPMR simulations, despite their abstruseness and high cost. (author)

  10. Neuropeptide Y-deficient mice show altered circadian response to simulated natural photoperiod.

    Science.gov (United States)

    Kim, Hyun Jung; Harrington, Mary E

    2008-12-30

    Circadian rhythms, endogenously generated by the suprachiasmatic nucleus (SCN), can be synchronized to a variety of photic and non-photic environmental stimuli. Neuropeptide Y (NPY) is produced in the intergeniculate leaflet (IGL) and known to mediate both photic and non-photic influences on the SCN. We recently found that npy-/- mice were slower to shift their locomotor activity onset to the new time of light offset when photoperiod was abruptly changed from light/dark (LD) cycle 18:6 to LD 6:18. In the present study, we measured the locomotor response of npy-/- mice to gradual changes in photoperiod (4 min a day) for 141 days (LD 16:8 changing to LD 8:16), mimicking external LD cycles in nature. When the photoperiod approached LD 8:16, npy-/- mice showed a significantly delayed onset of activity compared to wild-type mice. Activity patterns disintegrated into multiple bouts and intensity of activity decreased as the photoperiod changed and these changes were more pronounced in npy-/- mice. Our results lend further support to the idea that NPY is involved in circadian entrainment responses to seasonal photoperiod changes. PMID:18926801

  11. JAIF survey shows expansion of nuclear market but sees levelling-off

    International Nuclear Information System (INIS)

    The Japan Atomic Industrial Forum released the results of the fiscal 1984 survey of the nuclear industry in Japan, on December 18, 1985. The report showed that the nuclear industry maintained a strong expansionary trend as the nuclear related sales of mining and manufacturing industries were up by 26 % over the previous year to the total of 1,722.9 billion yen. However, there was a decrease in the expenditure of the electrical utility industry, which is the principal user, on nuclear power plant construction, as well as in the number of technical section workers in mining and manufacturing industries, which has reached the peak in the last couple of years. The report pointed out that the nuclear industry faces a period of adjustment after the end of the expansionary period, and that this basic pattern is likely to continue for several years, and the new order of nuclear power plants is likely to decline. This survey is the 26th of its kind by sending questionnaires to 1222 companies in 25 business sectors. 902 companies responded. The nuclear sales of mining and manufacturing industries, the investment for research facilities, nuclear-related workers, and the future market prospect are reported. (Kako, I.)

  12. The yeast Starmerella bacillaris (synonym Candida zemplinina) shows high genetic diversity in winemaking environments.

    Science.gov (United States)

    Masneuf-Pomarede, Isabelle; Juquin, Elodie; Miot-Sertier, Cécile; Renault, Philippe; Laizet, Yec'han; Salin, Franck; Alexandre, Hervé; Capozzi, Vittorio; Cocolin, Luca; Colonna-Ceccaldi, Benoit; Englezos, Vasileios; Girard, Patrick; Gonzalez, Beatriz; Lucas, Patrick; Mas, Albert; Nisiotou, Aspasia; Sipiczki, Matthias; Spano, Giuseppe; Tassou, Chrysoula; Bely, Marina; Albertin, Warren

    2015-08-01

    The yeast Candida zemplinina (Starmerella bacillaris) is frequently isolated from grape and wine environments. Its enological use in mixed fermentation with Saccharomyces cerevisiae has been extensively investigated these last few years, and several interesting features including low ethanol production, fructophily, glycerol and other metabolites production, have been described. In addition, molecular tools allowing the characterization of yeast populations have been developed, both at the inter- and intraspecific levels. However, most of these fingerprinting methods are not compatible with population genetics or ecological studies. In this work, we developed 10 microsatellite markers for the C. zemplinina species that were used for the genotyping of 163 strains from nature or various enological regions (28 vineyards/wineries from seven countries). We show that the genetic diversity of C. zemplinina is shaped by geographical localization. Populations isolated from winemaking environments are quite diverse at the genetic level: neither clonal-like behaviour nor specific genetic signature were associated with the different vineyards/wineries. Altogether, these results suggest that C. zemplinina is not under selective pressure in winemaking environments. PMID:26071435

  13. Satellite III non-coding RNAs show distinct and stress-specific patterns of induction

    International Nuclear Information System (INIS)

    The heat shock response in human cells is associated with the transcription of satellite III repeats (SatIII) located in the 9q12 locus. Upon induction, the SatIII transcripts remain associated with the locus and recruit several transcription and splicing factors to form the nuclear stress bodies (nSBs). The nSBs are thought to modulate epigenetic changes during the heat shock response. We demonstrate here that the nSBs are induced by a variety of stressors and show stress-specific patterns of induction. While the transcription factor HSF1 is required for the induction of SatIII locus by the stressors tested, its specific role in the transcriptional process appears to be stress dependent. Our results suggest the existence of multiple transcriptional loci for the SatIII transcripts and that their activation might depend upon the type of stressors. Thus, induction of SatIII transcripts appears to be a generic response to a variety of stress conditions.

  14. Text mining of the classical medical literature for medicines that show potential in diabetic nephropathy.

    Science.gov (United States)

    Zhang, Lei; Li, Yin; Guo, Xinfeng; May, Brian H; Xue, Charlie C L; Yang, Lihong; Liu, Xusheng

    2014-01-01

    Objectives. To apply modern text-mining methods to identify candidate herbs and formulae for the treatment of diabetic nephropathy. Methods. The method we developed includes three steps: (1) identification of candidate ancient terms; (2) systemic search and assessment of medical records written in classical Chinese; (3) preliminary evaluation of the effect and safety of candidates. Results. Ancient terms Xia Xiao, Shen Xiao, and Xiao Shen were determined as the most likely to correspond with diabetic nephropathy and used in text mining. A total of 80 Chinese formulae for treating conditions congruent with diabetic nephropathy recorded in medical books from Tang Dynasty to Qing Dynasty were collected. Sao si tang (also called Reeling Silk Decoction) was chosen to show the process of preliminary evaluation of the candidates. It had promising potential for development as new agent for the treatment of diabetic nephropathy. However, further investigations about the safety to patients with renal insufficiency are still needed. Conclusions. The methods developed in this study offer a targeted approach to identifying traditional herbs and/or formulae as candidates for further investigation in the search for new drugs for modern disease. However, more effort is still required to improve our techniques, especially with regard to compound formulae. PMID:24744808

  15. Calcium phosphate coating containing silver shows high antibacterial activity and low cytotoxicity and inhibits bacterial adhesion

    International Nuclear Information System (INIS)

    Surgical site infection is one of the serious complications of orthopedic implants. In order to reduce the incidence of implant-associated infections, we developed a novel coating technology of calcium phosphate (CP) containing silver (Ag), designated Ag-CP coating, using a thermal spraying technique. In this study, we evaluated the antibacterial efficacy and biological safety of this coating. In vitro antibacterial activity tests showed that the growths of Escherichia coli, Staphylococcus aureus and methicillin-resistant S. aureus (MRSA) are completely suppressed on Ag-CP coating. In vitro bacterial adherence tests revealed that the number of adherent bacteria on the surface of this coating is significantly less (p 2 CFU MRSA is inoculated. On the other hand, V79 Chinese hamster lung cells were found to grow on the Ag-CP coating as well as on the CP coating in a cytotoxicity test. These results indicate that the Ag-CP coating on the surface of orthopedic implants exhibits antibacterial activity and inhibits bacterial adhesion without cytotoxicity.

  16. Calcium phosphate coating containing silver shows high antibacterial activity and low cytotoxicity and inhibits bacterial adhesion

    Energy Technology Data Exchange (ETDEWEB)

    Ando, Yoshiki, E-mail: andoy@jmmc.jp [Division of Microbiology, Department of Pathology and Microbiology, Faculty of Medicine, Saga University, 5-1-1 Nabeshima, Saga 849-8501 (Japan); Research Department, Japan Medical Materials Corporation, Uemura Nissei Bldg.9F 3-3-31 Miyahara, Yodogawa-ku, Osaka 532-0003 (Japan); Miyamoto, Hiroshi [Division of Microbiology, Department of Pathology and Microbiology, Faculty of Medicine, Saga University, 5-1-1 Nabeshima, Saga 849-8501 (Japan); Noda, Iwao; Sakurai, Nobuko [Research Department, Japan Medical Materials Corporation, Uemura Nissei Bldg.9F 3-3-31 Miyahara, Yodogawa-ku, Osaka 532-0003 (Japan); Akiyama, Tomonori [Division of Microbiology, Department of Pathology and Microbiology, Faculty of Medicine, Saga University, 5-1-1 Nabeshima, Saga 849-8501 (Japan); Yonekura, Yutaka; Shimazaki, Takafumi; Miyazaki, Masaki; Mawatari, Masaaki; Hotokebuchi, Takao [Department of Orthopaedic Surgery, Faculty of Medicine, Saga University, 5-1-1 Nabeshima, Saga 849-8501 (Japan)

    2010-01-01

    Surgical site infection is one of the serious complications of orthopedic implants. In order to reduce the incidence of implant-associated infections, we developed a novel coating technology of calcium phosphate (CP) containing silver (Ag), designated Ag-CP coating, using a thermal spraying technique. In this study, we evaluated the antibacterial efficacy and biological safety of this coating. In vitro antibacterial activity tests showed that the growths of Escherichia coli, Staphylococcus aureus and methicillin-resistant S. aureus (MRSA) are completely suppressed on Ag-CP coating. In vitro bacterial adherence tests revealed that the number of adherent bacteria on the surface of this coating is significantly less (p < 0.02) than that on the surface of the CP coating. Moreover, the Ag-CP coating completely inhibits MRSA adhesion [<10 colony-forming units (CFU)] when 10{sup 2} CFU MRSA is inoculated. On the other hand, V79 Chinese hamster lung cells were found to grow on the Ag-CP coating as well as on the CP coating in a cytotoxicity test. These results indicate that the Ag-CP coating on the surface of orthopedic implants exhibits antibacterial activity and inhibits bacterial adhesion without cytotoxicity.

  17. High-throughput oncogene mutation profiling shows demographic differences in BRAF mutation rates among melanoma patients.

    Science.gov (United States)

    van den Hurk, Karin; Balint, Balazs; Toomey, Sinead; O'Leary, Patrick C; Unwin, Louise; Sheahan, Kieran; McDermott, Enda W; Murphy, Ian; van den Oord, Joost J; Rafferty, Mairin; FitzGerald, Dara M; Moran, Julie; Cummins, Robert; MacEneaney, Owen; Kay, Elaine W; O'Brien, Cathal P; Finn, Stephen P; Heffron, Cynthia C B B; Murphy, Michelle; Yela, Ruben; Power, Derek G; Regan, Padraic J; McDermott, Clodagh M; O'Keeffe, Allan; Orosz, Zsolt; Donnellan, Paul P; Crown, John P; Hennessy, Bryan T; Gallagher, William M

    2015-06-01

    Because of advances in targeted therapies, the clinical evaluation of cutaneous melanoma is increasingly based on a combination of traditional histopathology and molecular pathology. Therefore, it is necessary to expand our knowledge of the molecular events that accompany the development and progression of melanoma to optimize clinical management. The central objective of this study was to increase our knowledge of the mutational events that complement melanoma progression. High-throughput genotyping was adapted to query 159 known single nucleotide mutations in 33 cancer-related genes across two melanoma cohorts from Ireland (n=94) and Belgium (n=60). Results were correlated with various clinicopathological characteristics. A total of 23 mutations in 12 genes were identified, that is - BRAF, NRAS, MET, PHLPP2, PIK3R1, IDH1, KIT, STK11, CTNNB1, JAK2, ALK, and GNAS. Unexpectedly, we discovered significant differences in BRAF, MET, and PIK3R1 mutations between the cohorts. That is, cases from Ireland showed significantly lower (Pmanagement of this disease. PMID:25746038

  18. A mechanical wave system to show waveforms similar to quantum mechanical wavefunctions in a potential

    Science.gov (United States)

    Faleti?, Sergej

    2015-05-01

    Interviews with students suggest that even though they understand the formalism and the formal nature of quantum theory, they still often desire a mental picture of what the equations describe and some tangible experience with the wavefunctions. Here we discuss a mechanical wave system capable of reproducing correctly a mechanical equivalent of a quantum system in a potential, and the resulting waveforms in principle of any form. We have successfully reproduced the finite potential well, the potential barrier and the parabolic potential. We believe that these mechanical waveforms can provide a valuable experience base for introductory students to start from. We aim to show that mechanical systems that are described with the same mathematics as quantum mechanical, indeed behave in the same way. We believe that even if treated purely as a wave phenomenon, the system provides much insight into wave mechanics. This can be especially useful for physics teachers and others who often need to resort to concepts and experience rather than mathematics when explaining physical phenomena.

  19. Insect antimicrobial peptides show potentiating functional interactions against Gram-negative bacteria.

    Science.gov (United States)

    Rahnamaeian, Mohammad; Cytry?ska, Ma?gorzata; Zdybicka-Barabas, Agnieszka; Dobslaff, Kristin; Wiesner, Jochen; Twyman, Richard M; Zuchner, Thole; Sadd, Ben M; Regoes, Roland R; Schmid-Hempel, Paul; Vilcinskas, Andreas

    2015-05-01

    Antimicrobial peptides (AMPs) and proteins are important components of innate immunity against pathogens in insects. The production of AMPs is costly owing to resource-based trade-offs, and strategies maximizing the efficacy of AMPs at low concentrations are therefore likely to be advantageous. Here, we show the potentiating functional interaction of co-occurring insect AMPs (the bumblebee linear peptides hymenoptaecin and abaecin) resulting in more potent antimicrobial effects at low concentrations. Abaecin displayed no detectable activity against Escherichia coli when tested alone at concentrations of up to 200 ?M, whereas hymenoptaecin affected bacterial cell growth and viability but only at concentrations greater than 2 ?M. In combination, as little as 1.25 ?M abaecin enhanced the bactericidal effects of hymenoptaecin. To understand these potentiating functional interactions, we investigated their mechanisms of action using atomic force microscopy and fluorescence resonance energy transfer-based quenching assays. Abaecin was found to reduce the minimal inhibitory concentration of hymenoptaecin and to interact with the bacterial chaperone DnaK (an evolutionarily conserved central organizer of the bacterial chaperone network) when the membrane was compromised by hymenoptaecin. These naturally occurring potentiating interactions suggest that combinations of AMPs could be used therapeutically against Gram-negative bacterial pathogens that have acquired resistance to common antibiotics. PMID:25833860

  20. Results from LHCf Experiment

    Directory of Open Access Journals (Sweden)

    Tricomi Alessia

    2012-06-01

    Full Text Available The LHCf experiment has taken data in 2009 and 2010 p-p collisions at LHC at ?s = 0.9 TeV and ?s = 7 TeV. The measurement of the forward neutral particle spectra produced in proton-proton collisions at LHC up to an energy of 14 TeV in the center of mass system are of fundamental importance to calibrate the Monte Carlo models widely used in the high energy cosmic ray (HECR field, up to an equivalent laboratory energy of the order of 1017 eV. In this paper the first results on the inclusive photon spectrum measured by LHCf is reported. Comparison of this spectrum with the model expectations show significant discrepancies, mainly in the high energy region. In addition, perspectives for future analyses as well as the program for the next data taking period, in particular the possibility to take data in p-Pb collisions, will be discussed.

  1. Results of DT experiments

    International Nuclear Information System (INIS)

    The results of TFTR DT experiments are reviewed with the author' comments. A maximum fusion power of 10.7MW was produced in TFTR deuterium-tritium (DT) experiments, using nearly equal concentrations of deuterium and tritium. The particle diffusivities of tritium and 4He, and the deuterium thermal diffusivity are of similar magnitudes. Measurements of the loss of alpha particles in DT plasmas show no new loss mechanism. Initial measurements of alpha ash from DT reactions indicate that the transport coefficients of alpha ash are consistent with those for helium introduced to the plasma by gas puffing. DT plasmas with enhanced energy confinement have been obtained in the high poloidal beta. ICRF heating of a DT plasma has demonstrated ion and electron heating. (author)

  2. Educação escolar hospitalar: o que mostram as pesquisas? / Education during hospital care: what the research shows?

    Scientific Electronic Library Online (English)

    Gilda Maria Maia Martins, Saldanha; Regina Rovigati, Simões.

    2013-09-01

    Full Text Available O objetivo do estudo foi conhecer a evolução e as principais abordagens sobre a educação escolar hospitalar, retratadas em artigos científicos postados on-line, nos últimos quinze anos (1996 a 2010). A metodologia, do tipo estado da arte, encontrou 82 artigos nas bases de dados eletrônicos (Scielo e [...] Google Acadêmico), interpretados pela Análise de Conteúdo. Os resultados foram organizados em cinco categorias: Concepções e significados (25,61%); Relação educação e saúde (15,85%); Práticas pedagógicas e configuração didático-curricular (23,17%); Aspectos históricos, organizacionais e legais (13,42%) e Formação de professores (21,95%), mostrando a necessidade de maior número de investigações sobre a formação de professores, as vivências dos alunos em tratamento de saúde na escola regular, o processo de reinserção escolar e as práticas pedagógicas com enfoque na didática e no currículo. Apontaram ainda a urgente ampliação de políticas públicas que concorram para uma melhor legitimidade da escolarização de crianças em tratamento de saúde. Os achados contribuíram para a compreensão de como esse tipo de educação vem sendo desenvolvido nas diversas regiões do país, por meio das vozes de professores, alunos, pais e pesquisadores de hospitais e universidades. Abstract in english The goal of the study was to analyze the evolution and the main approaches regarding education offered to children during hospitalization reported in scientific articles posted online in the last fifteen years (1996 to 2010). The methodology used was state of the art, and 82 articles were found on t [...] he internet (Scielo and Google Scholar) and interpreted through content analysis. The results were organized according to 5 categories: Conceptions and Meaning (25,61%); Education and Health Interaction (15,85%); Pedagogical Practices and Didactic Curricular Configurations (23,17%); Historical, organizational and legal aspects (13,42%) and Teacher Preparation (21,95%), showing the need for increasing the focus on teacher preparation, student experience undergoing medical treatment, the reintegration process in school and pedagogical practices with emphasis on didactics and curriculum. The results further indicated the urgent increase of public policies needed to consolidate schooling for children undergoing medical treatment. The results helped to understand how this type of education has been carried out in different regions of the country, by presenting students', teachers', parents' and university and hospital researchers' points of view.

  3. Neurocognitive Function in Pediatric Bipolar Disorder: 3-Year Follow-Up Shows Cognitive Development Lagging behind Healthy Youths

    Science.gov (United States)

    Pavuluri, Mani N.; West, Amy; Hill, Kristian; Jindal, Kittu; Sweeney, John A.

    2009-01-01

    The comparison of the neurocognitive functioning of people with pediatric bipolar disorder (PBD) with a control group shows that the developmental progress in executive functions and verbal memory of those with PBD was significantly less than those in the control group. The results were seen after comparing data from baseline cognitive tests and a…

  4. Bosutinib shows low cross intolerance, in chronic myeloid leukemia patients treated in fourth line. Results of the Spanish compassionate use program.

    Science.gov (United States)

    García-Gutiérrez, Valentín; Martinez-Trillos, Alejandra; Lopez Lorenzo, Jose Luis; Bautista, Guiomar; Martin Mateos, Maria Luisa; Alvarez-Larrán, Alberto; Iglesias Pérez, Ana; Romo Collado, Andrés; Fernandez, Angeles; Portero, Angeles; Cuevas, Beatriz; Ruiz, Concepción; Romero, Esperanza; Ortega, Fernando; Mata, Isabel; Tallón, José; García Garay, Maria Del Carmen; Ramirez Sánchez, María José; de Las Heras, Natalia; Giraldo, Pilar; Bobillo, Sabela; Guinea, José María; Deben, Guillermo; Valencia, Sandra; Sebrango, Ana; Boqué, Concepción; Maestro, Begoña; Steegmann, Juan Luis

    2015-05-01

    The role of bosutinib as rescue treatment of Philadelphia chromosome-positive chronic myeloid leukemia (CML) patients after failing three previous tyrosine kinase inhibitors (TKIs) is currently unknown. We report here the largest series (to our knowledge) of patients treated with bosutinib in fourth-line, after retrospectively reviewing 30 patients in chronic phase, and pretreated with imatinib, nilotinib, and dasatinib. With a median follow up of 11.1 months, the probability to either maintain or improve their CCyR response was 56.6% (17/30) and 11 patients (36.7%) achieved or maintained their baseline MMR. In patients not having baseline CCyR, the probabilities of obtaining CCyR, MMR, and MR4.5 were 13, 11, and 14%, respectively. The probabilities of obtaining MMR and deep molecular response MR4.5 in patients with baseline CCyR were 40.0% (6/15) and 20.0% (3/15). At 20 months, progression-free survival was 73%. Grade 3-4 hematological toxicities were more frequent in resistant than intolerant patients (45.4 vs. 0.0%). Nonhematological toxicities were also more frequent in resistant patients, being diarrhea the most conspicuous one. Bosutinib seems to be an appropriate treatment option for patients resistant or intolerant to three prior TKI's.Am. J. Hematol. 90:429-433, 2015. © 2015 Wiley Periodicals, Inc. PMID:25683327

  5. A small charge for a big result: The case of M&S shows that choice can encourage positive environmental behaviour

    OpenAIRE

    Le Grand, Julian; Disney, Kate

    2011-01-01

    Encouraging individuals to change their behaviour towards the environment is an increasingly important area of policy-making. Julian Le Grand and Kate Disney find that the introduction of a charge for plastic bags in Marks and Spencer shops successfully encouraged pro-environmental behaviour and explore the implications for environmental policy.

  6. Use of High Throughput Sequencing and Light Microscopy Show Contrasting Results in a Study of Phytoplankton Occurrence in a Freshwater Environment

    OpenAIRE

    Xiao, Xi; Sogge, Hanne; Lagesen, Karin; Tooming-Klunderud, Ave; Jakobsen, Kjetill S.; Rohrlack, Thomas

    2014-01-01

    Assessing phytoplankton diversity is of primary importance for both basic and applied ecological studies. Following the advances in molecular methods, phytoplankton studies are switching from using classical microscopy to high throughput sequencing approaches. However, methodological comparisons of these approaches have rarely been reported. In this study, we compared the two methods, using a unique dataset of multiple water samples taken from a natural freshwater environment. Environmental D...

  7. Spacelab Science Results Study

    Science.gov (United States)

    Naumann, R. J.; Lundquist, C. A.; Tandberg-Hanssen, E.; Horwitz, J. L.; Germany, G. A.; Cruise, J. F.; Lewis, M. L.; Murphy, K. L.

    2009-01-01

    Beginning with OSTA-1 in November 1981 and ending with Neurolab in March 1998, a total of 36 Shuttle missions carried various Spacelab components such as the Spacelab module, pallet, instrument pointing system, or mission peculiar experiment support structure. The experiments carried out during these flights included astrophysics, solar physics, plasma physics, atmospheric science, Earth observations, and a wide range of microgravity experiments in life sciences, biotechnology, materials science, and fluid physics which includes combustion and critical point phenomena. In all, some 764 experiments were conducted by investigators from the U.S., Europe, and Japan. The purpose of this Spacelab Science Results Study is to document the contributions made in each of the major research areas by giving a brief synopsis of the more significant experiments and an extensive list of the publications that were produced. We have also endeavored to show how these results impacted the existing body of knowledge, where they have spawned new fields, and if appropriate, where the knowledge they produced has been applied.

  8. Impact of Reality Television Shows on Expatriate Indians in Sultanate of Oman

    Directory of Open Access Journals (Sweden)

    Radhakrishnan Subramaniam

    2015-02-01

    Full Text Available The aim of this paper is to analyze the impact of reality television shows. The objective is to examine the impact of reality television shows among the expatriate parents and children. A sample of 50 households is taken for the study from Nizwa, Sultanate of Oman. The analysis revealed that mothers are more aware of the negative effects of reality shows than fathers. Parents feel that television reality shows help participants to showcase their talents and also to earn quick money. Among the children boys are highly aware of negative effects of television reality shows than girls. It is also found that there is a difference in the preference of channel, reality shows, viewing time between boys and girls.

  9. International fashion trade shows as knowledge creation platforms for Finnish microenterprises

    OpenAIRE

    Cheng, Heidi

    2014-01-01

    Objective of the Study: The prevailing view in the literature is that trade shows act as a platform for promotional and selling activities. However, there is increased recognition that trade shows are more sources of information and contacts than places where purchases are made and thus act as an organizational context for learning and interaction. In this study, the organizational knowledge creation process of microenterprises exhibiting in fashion trade shows are explored. Specifically,...

  10. Writing Games: Continuity and Change in the Design and Development of Quiz Shows in Italy

    OpenAIRE

    Massimo Scaglioni; Axel Fiacco

    2013-01-01

    As in the United States and in many countries across Europe, the quiz show was a founding genre for Italian television as far back as the 1950s: because of their broad appeal, such game shows as Lascia o raddoppia and Il musichiere contributed strongly to television’s burgeoning popularity during the subsequent decades. Since then, the quiz show has traversed different eras of television history, with partial and gradual changes to its textual features, aesthetics and narratives, as well as...

  11. A mechanically-induced colon cancer cell population shows increased metastatic potential

    KAUST Repository

    Tang, Xin

    2014-05-29

    Background: Metastasis accounts for the majority of deaths from cancer. Although tumor microenvironment has been shown to have a significant impact on the initiation and/or promotion of metastasis, the mechanism remains elusive. We previously reported that HCT-8 colon cancer cells underwent a phenotypic transition from an adhesive epithelial type (E-cell) to a rounded dissociated type (R-cell) via soft substrate culture, which resembled the initiation of metastasis. The objective of current study was to investigate the molecular and metabolic mechanisms of the E-R transition.Methods: Global gene expressions of HCT-8 E and R cells were measured by RNA Sequencing (RNA-seq); and the results were further confirmed by real-time PCR. Reactive oxygen species (ROS), anoikis resistance, enzyme activity of aldehyde dehydrogenase 3 family, member A1 (ALDH3A1), and in vitro invasion assay were tested on both E and R cells. The deformability of HCT-8 E and R cells was measured by atomic force microscopy (AFM). To study the in vivo invasiveness of two cell types, athymic nude mice were intra-splenically injected with HCT-8 E or R cells and sacrificed after 9 weeks. Incidences of tumor development and metastasis were histologically evaluated and analyzed with Fisher\\'s exact test.Results: Besides HCT-8, E-R transition on soft substrates was also seen in three other cancer cell lines (HCT116, SW480 colon and DU145 prostate cancer). The expression of some genes, such as ALDH3A1, TNS4, CLDN2, and AKR1B10, which are known to play important roles in cancer cell migration, invasion, proliferation and apoptosis, were increased in HCT-8 R cells. R cells also showed higher ALDH3A1 enzyme activity, higher ROS, higher anoikis resistance, and higher softness than E cells. More importantly, in vitro assay and in vivo animal models revealed that HCT-8 R cells were more invasive than E cells.Conclusions: Our comprehensive comparison of HCT-8 E and R cells revealed differences of molecular, phenotypical, and mechanical signatures between the two cell types. To our knowledge, this is the first study that explores the molecular mechanism of E-R transition, which may greatly increase our understanding of the mechanisms of cancer mechanical microenvironment and initiation of cancer metastasis. 2014 Tang et al.; licensee BioMed Central Ltd.

  12. The endoperoxide ascaridol shows strong differential cytotoxicity in nucleotide excision repair-deficient cells

    International Nuclear Information System (INIS)

    Targeting synthetic lethality in DNA repair pathways has become a promising anti-cancer strategy. However little is known about such interactions with regard to the nucleotide excision repair (NER) pathway. Therefore, cell lines with a defect in the NER genes ERCC6 or XPC and their normal counterparts were screened with 53 chemically defined phytochemicals isolated from plants used in traditional Chinese medicine for differential cytotoxic effects. The screening revealed 12 drugs that killed NER-deficient cells more efficiently than proficient cells. Five drugs were further analyzed for IC50 values, effects on cell cycle distribution, and induction of DNA damage. Ascaridol was the most effective compound with a difference of > 1000-fold in resistance between normal and NER-deficient cells (IC50 values for cells with deficiency in ERCC6: 0.15 ?M, XPC: 0.18 ?M, and normal cells: > 180 ?M). NER-deficiency combined with ascaridol treatment led to G2/M-phase arrest, an increased percentage of subG1 cells, and a substantially higher DNA damage induction. These results were confirmed in a second set of NER-deficient and -proficient cell lines with isogenic background. Finally, ascaridol was characterized for its ability to generate oxidative DNA damage. The drug led to a dose-dependent increase in intracellular levels of reactive oxygen species at cytotoxic concentrations, but only NER-deficient cells showed a strongly induced amount of 8-oxodG sites. In summary, ascaridol is a cytotoxic and DNA-damaging compound which generates intracellular reactive oxidative intermediates and which selectively affects NER-deficient cells. This could provide a new therapeutic option to treat cancer cells with mutations in NER genes. -- Highlights: ? Thousand-fold higher Ascaridol activity in NER-deficient versus proficient cells. ? Impaired repair of Ascaridol-induced oxidative DNA damage in NER-deficient cells. ? Selective activity of Ascaridol opens new therapy options in NER-deficient tumors.

  13. A THYROID GLAND SHOWING PYRAMIDAL LOBE WITH LEVATO R GLANDULAE THYROIDEA .

    Directory of Open Access Journals (Sweden)

    Sreekanth

    2013-01-01

    Full Text Available ABSTRACT: The Literature is replete with wide range of common and rare variations of thyroid gland. The presence of pyramidal lobe (accessory lo be – a rostral directed stalk that results from the retention and growth of the caudal end of thyroglossal duct and fibrous or fibromuscular levator glandulae thyroidea (LGT ari sing from its apex are commonly occurring variations . A 50 yrs Old Male Cadaver showed leva tor glandulae thyroidea with cranio caudal extension from the body of the hyoid bone to the ap ex of pyramidal lobe which was projecting upwards from the left ¾ th of isthmus without any encroachment on the left lo be of the thyroid gland. In the groove clearly demarcating pyramidal lobe from the left lobe, a glandular branch of anterior branch of left superior thyroid artery w as seen. It entered the pyramidal lobe inferiorly, just above the lower border of the isth mus. Just adjacent to the right lobe a small portion of isthmus with prominent and free upper border and lower border is seen. Due its frequent presence it may not be fascinating to the Anatomists but can definitely challenge the skill o f operating neck surgeons performing thyroidectomies, lobectomies and isthmusectomies an d Otolaryngologists performing tracheostomies ,tracheotomies and laryngotomies. T he wide range of variations in the number, size, extent and consistency of the levator glandul ae thyroidea (LGT and pyramidal lobe necessitate the pre operative ultrasonographic examina tion or scintigraphical images or intense contrast enhancement on CT/MRI scan for total anato mical details enabling relatively a safer surgery.

  14. Analysis of allergen immunotherapy studies shows increased clinical efficacy in highly symptomatic patients

    DEFF Research Database (Denmark)

    Howarth, P; Malling, Hans-JØrgen

    2011-01-01

    To cite this article: Howarth P, Malling H-J, Molimard M, Devillier P. Analysis of allergen immunotherapy studies shows increased clinical efficacy in highly symptomatic patients. Allergy 2012; 67: 321-327. ABSTRACT: Background:? The assessment of allergen immunotherapy (AIT) efficacy in the treatment for seasonal allergic rhinoconjunctivitis (SAR) symptoms is challenging. Allergen immunotherapy differs from symptomatic therapy in that while symptomatic therapy treats patients after symptoms appear and aims to reduce symptoms, AIT is administered before symptoms are present and aims to prevent them. Thus, clinical studies of AIT can neither establish baseline symptom levels nor limit the enrolment of patients to those with the most severe symptoms. Allergen immunotherapy treatment effects are therefore diluted by patients with low symptoms for a particular pollen season. The objective of this analysis was to assess the effect possible to achieve with AIT in the groups of patients presenting the most severe allergic symptoms. Methods:? Study centres were grouped into tertiles categorized according to symptom severity scores observed in the placebo patients in each centre (low, middle and high tertiles). The difference observed in the average score in each tertile in active vs placebo-treated patients was assessed. This allowed an estimation of the efficacy that could be achieved in patients from sites where symptoms were high during the pollen season. Results:? An increased treatment effect was observed in the most severe patients and was independent of the study analysed and symptom score used. Conclusions:? The use of a tertile approach to analyse efficacy in AIT in SAR clinical studies can give a more accurate assessment of potential clinical benefit.

  15. Trabeculated embryonic myocardium shows rapid stress relaxation and non-quasi-linear viscoelastic behavior.

    Science.gov (United States)

    Miller, C E; Wong, C L

    2000-05-01

    Passive viscoelastic behavior is important in embryonic cardiovascular function, influencing the rate and magnitude of contraction and relaxation. We hypothesized that if viscoelastic behavior is influenced by interstitial fluid flow, then the stage-21 (312d) and stage-24 (4d) chick myocardium with large intertrabecular spaces will exhibit much different viscoelastic behavior than stage-16 (212d) and stage-18 (3d) compact myocardium and a non-quasi-linear response. Excised left ventricular sections were tested with ramp-and-hold stress relaxation tests at axial stretch ratios of 1.05:1.1:1.2:1.3. The measured stress relaxation was much more rapid than previously observed in the compact, non-trabeculated myocardium. The reduced relaxation curves depended significantly on the stretch level. A continuous-spectrum quasi-linear relaxation function described their shape well but the model-fit parameters also depended on the stretch level. Sinusoidal stretching of ventricular sections at rates from 0.2 to 25Hz showed that the steepening of stress-strain curves with increasing strain rate was half as much as predicted by a quasi-linear model. Hysteresis ranged from 25-35%, varied little with loading rate from 0.2 to 8Hz, and was twice that predicted from a quasi-linear model. Doubling the viscosity of the perfusate in stress-relaxation tests produced increased stiffness and decreased relaxation rate. These results demonstrate that the passive viscoelastic behavior of the trabeculated embryonic myocardium is markedly different from that of younger, compact myocardium and is not quasi-linear. PMID:10708783

  16. Markers typed in genome-wide analysis identify regions showing deviation from Hardy-Weinberg equilibrium

    Directory of Open Access Journals (Sweden)

    Curtis David

    2009-03-01

    Full Text Available Abstract Background Deviations from Hardy-Weinberg equilibrium (HWE are commonly thought of as indicating genotyping errors, population stratification or some other artefact. However they could also arise through important biological mechanisms. In particular, genetic variants having a recessive effect on the successful fertilisation and/or development of an embryo might be manifest through such deviations in an unselected sample of "control" subjects. Findings We investigated genotypes from 463842 autosomal markers from 1504 British subjects. We identified regions in which several neighbouring markers exhibited deviation from HWE in the same direction by considering "heterozygosity scores" in windows of 10 markers. The heterozygosity score for each marker was defined as -log(p or log(p according to whether the marker demonstrated increased heterozygosity or homozygosity. In each window the marker with the highest absolute score was ignored and the positive and negative scores were summed for the other nine markers. Windows were selected on the basis of this sum exceeding a given threshold, for which we used values of 50 or 15. For the threshold of 50, we identified 7 regions with increased heterozygosity and for the threshold of 15 we identified 22 regions with increased heterozygosity, 23 with increased homozygosity and 2 containing both kinds of window. The most impressive of these results came from a group of 6 markers at 17q21, each of which showed increased heterozygosity significant at p -190. Conclusion The human genome contains regions which deviate markedly from HWE and these might harbour genes influencing embryonic survival.

  17. Pattern of neural responses to verbal fluency shows diagnostic specificity for schizophrenia and bipolar disorder

    Directory of Open Access Journals (Sweden)

    Walshe Muriel

    2011-01-01

    Full Text Available Abstract Background Impairments in executive function and language processing are characteristic of both schizophrenia and bipolar disorder. Their functional neuroanatomy demonstrate features that are shared as well as specific to each disorder. Determining the distinct pattern of neural responses in schizophrenia and bipolar disorder may provide biomarkers for their diagnoses. Methods 104 participants underwent functional magnetic resonance imaging (fMRI scans while performing a phonological verbal fluency task. Subjects were 32 patients with schizophrenia in remission, 32 patients with bipolar disorder in an euthymic state, and 40 healthy volunteers. Neural responses to verbal fluency were examined in each group, and the diagnostic potential of the pattern of the neural responses was assessed with machine learning analysis. Results During the verbal fluency task, both patient groups showed increased activation in the anterior cingulate, left dorsolateral prefrontal cortex and right putamen as compared to healthy controls, as well as reduced deactivation of precuneus and posterior cingulate. The magnitude of activation was greatest in patients with schizophrenia, followed by patients with bipolar disorder and then healthy individuals. Additional recruitment in the right inferior frontal and right dorsolateral prefrontal cortices was observed in schizophrenia relative to both bipolar disorder and healthy subjects. The pattern of neural responses correctly identified individual patients with schizophrenia with an accuracy of 92%, and those with bipolar disorder with an accuracy of 79% in which mis-classification was typically of bipolar subjects as healthy controls. Conclusions In summary, both schizophrenia and bipolar disorder are associated with altered function in prefrontal, striatal and default mode networks, but the magnitude of this dysfunction is particularly marked in schizophrenia. The pattern of response to verbal fluency is highly diagnostic for schizophrenia and distinct from bipolar disorder. Pattern classification of functional MRI measurements of language processing is a potential diagnostic marker of schizophrenia.

  18. Cadmium in Salix. A study to show the capacity of Salix to remove cadmium from farmland

    International Nuclear Information System (INIS)

    The aim of this report has been to show the ability of Salix to take up cadmium and how the uptake varies between different types of soil. The information that the results are based on has been obtained from analyses of soil and Salix. The samples were taken at five sites in the district around Lake Maelaren. Two or three stands were taken at each place. The factors studied were the pH, the organic matter content, and the concentration of cadmium in the soil. Salix has a good ability, relative to other crops, to remove cadmium from arable land. The cadmium uptake is 35 times higher with Salix than with straw or energy grass. Salix uptake of cadmium varies between 3 and 14% of the cadmium content in the soil that is accessible to plants. The present annual increase of cadmium in arable land is 1 g/ha, whereas the removal in a Salix plantation is 21 g Cd/ha, yr at an annual growth of 10 tonnes DM. If the Cd uptake is the same each year, then a total of 420 g Cd/ha is removed when Salix is grown over a 20-year period. This is a very large part of the topsoil's total cadmium content, which is 550 g/ha on average in Sweden. The investigation reveals no clear relationship between the Cd concentration in Salix and the concentration of Cd in the soil, the organic matter content or the pH. 22 refs, 4 figs, 2 tabs

  19. Pten haploinsufficient mice show broad brain overgrowth but selective impairments in autism-relevant behavioral tests.

    Science.gov (United States)

    Clipperton-Allen, Amy E; Page, Damon T

    2014-07-01

    Accelerated head and brain growth (macrocephaly) during development is a replicated biological finding in a subset of individuals with autism spectrum disorder (ASD). However, the relationship between brain overgrowth and the behavioral and cognitive symptoms of ASD is poorly understood. The PI3K-Akt-mTOR pathway regulates cellular growth; several genes encoding negative regulators of this pathway are ASD risk factors, including PTEN. Mutations in PTEN have been reported in individuals with ASD and macrocephaly. We report that brain overgrowth is widespread in Pten germline haploinsufficient (Pten(+/-)) mice, reflecting Pten mRNA expression in the developing brain. We then ask if broad brain overgrowth translates into general or specific effects on the development of behavior and cognition by testing Pten(+/-) mice using assays relevant to ASD and comorbidities. Deficits in social behavior were observed in both sexes. Males also showed abnormalities related to repetitive behavior and mood/anxiety. Females exhibited circadian activity and emotional learning phenotypes. Widespread brain overgrowth together with selective behavioral impairments in Pten(+/-) mice raises the possibility that most brain areas and constituent cell types adapt to an altered trajectory of growth with minimal impact on the behaviors tested in our battery; however, select areas/cell types relevant to social behavior are more vulnerable or less adaptable, thus resulting in social deficits. Probing dopaminergic neurons as a candidate vulnerable cell type, we found social behavioral impairments in mice with Pten conditionally inactivated in dopaminergic neurons that are consistent with the possibility that desynchronized growth in key cell types may contribute to ASD endophenotypes. PMID:24497577

  20. Three different Plasmodium species show similar patterns of clinical tolerance of malaria infection

    Directory of Open Access Journals (Sweden)

    Zimmerman Peter

    2009-07-01

    Full Text Available Abstract Background In areas where malaria endemicity is high, many people harbour blood stage parasites without acute febrile illness, complicating the estimation of disease burden from infection data. For Plasmodium falciparum the density of parasitaemia that can be tolerated is low in the youngest children, but reaches a maximum in the age groups at highest risk of infection. There is little data on the age dependence of tolerance in other species of human malaria. Methods Parasite densities measured in 24,386 presumptive malaria cases at two local health centres in the Wosera area of Papua New Guinea were compared with the distributions of parasite densities recorded in community surveys in the same area. We then analyse the proportions of cases attributable to each of Plasmodium falciparum, P. vivax, and P. malariae as functions of parasite density and age using a latent class model. These attributable fractions are then used to compute the incidence of attributable disease. Results Overall 33.3%, 6.1%, and 0.1% of the presumptive cases were attributable to P. falciparum, P. vivax, and P. malariae respectively. The incidence of attributable disease and parasite density broadly follow similar age patterns. The logarithm of the incidence of acute illness is approximately proportion to the logarithm of the parasite density for all three malaria species, with little age variation in the relationship for P. vivax or P. malariae. P. falciparum shows more age variation in disease incidence at given levels of parasitaemia than the other species. Conclusion The similarities between Plasmodium species in the relationships between parasite density and risk of attributable disease are compatible with the hypothesis that pan-specific mechanisms may regulate tolerance to different human Plasmodia. A straightforward mathematical expression might be used to project disease burden from parasite density distributions assessed in community-based parasitological surveys.

  1. Adrenal incidentalomas showing unilateral concordant visualization by adrenocortical scintigraphy. Comparison with adenomas in Cushing's syndrome

    International Nuclear Information System (INIS)

    An adrenocortical adenoma causing Cushing's syndrome (Cushing's adenoma) produces a unilateral concordant visualization (UCV) imaging pattern in which the adenoma is only visualized on radioiodocholesterol adrenocortical scintigraphy. But because this imaging pattern is also noted in some patients with adrenal incidentalomas, we examined whether the UCV-incidentaloma was essentially identical with Cushing's adenoma and would develop Cushing's syndrome. The subjects were 9 patients with UCV-incidentalomas (mean size, 30 mm; range, 20-45 mm) and 6 patients with Cushing's adenomas (mean size, 28 mm; range, 25-35 mm). Endocrinological evaluations showed several abnormalities including blunted diurnal rhythm of plasma cortisol within the normal range, low plasma ACTH and/or high 24-hr urinary 17-OHCS levels in 8 of 9 patients with UCV-incidentalomas, but these abnormalities did not meet the diagnostic criteria of Cushing's syndrome. Adrenal uptake of the tracer in the patients with UCV-incidentalomas was not statistically different from that in the patients with Cushing's adenomas and had no relationship with hormonal values in either patient group. Tumor size on CT correlated with the levels of 24-hr urinary 17-OHCS (r=0.75, p=0.02) and plasma cortisol at 7:00 (r=0.82, p=0.007) in the patients with UCV-incidentalomas, but not in the patients with Cushing's adenomas. Although 3 UCV-incidentalomas increased slightly in size, none of 9 patients with UCV-incidentalomas has de 9 patients with UCV-incidentalomas has developed Cushing's syndrome for 4 to 52 months. These results suggest that the UCV-incidentaloma may be essentially different from the Cushing's adenoma and unlikely to develop Cushing's syndrome. (author)

  2. Combined MEG and EEG show reliable patterns of electromagnetic brain activity during natural viewing.

    Science.gov (United States)

    Chang, Wei-Tang; Jääskeläinen, Iiro P; Belliveau, John W; Huang, Samantha; Hung, An-Yi; Rossi, Stephanie; Ahveninen, Jyrki

    2015-07-01

    Naturalistic stimuli such as movies are increasingly used to engage cognitive and emotional processes during fMRI of brain hemodynamic activity. However, movies have been little utilized during magnetoencephalography (MEG) and EEG that directly measure population-level neuronal activity at a millisecond resolution. Here, subjects watched a 17-min segment from the movie Crash (Lionsgate Films, 2004) twice during simultaneous MEG/EEG recordings. Physiological noise components, including ocular and cardiac artifacts, were removed using the DRIFTER algorithm. Dynamic estimates of cortical activity were calculated using MRI-informed minimum-norm estimation. To improve the signal-to-noise ratio (SNR), principal component analyses (PCA) were employed to extract the prevailing temporal characteristics within each anatomical parcel of the Freesurfer Desikan-Killiany cortical atlas. A variety of alternative inter-subject correlation (ISC) approaches were then utilized to investigate the reliability of inter-subject synchronization during natural viewing. In the first analysis, the ISCs of the time series of each anatomical region over the full time period across all subject pairs were calculated and averaged. In the second analysis, dynamic ISC (dISC) analysis, the correlation was calculated over a sliding window of 200 ms with 3.3 ms steps. Finally, in a between-run ISC analysis, the between-run correlation was calculated over the dynamic ISCs of the two different runs after the Fisher z-transformation. Overall, the most reliable activations occurred in occipital/inferior temporal visual and superior temporal auditory cortices as well as in the posterior cingulate, precuneus, pre- and post-central gyri, and right inferior and middle frontal gyri. Significant between-run ISCs were observed in superior temporal auditory cortices and inferior temporal visual cortices. Taken together, our results show that movies can be utilized as naturalistic stimuli in MEG/EEG similarly as in fMRI studies. PMID:25842290

  3. Do North Atlantic eels show parallel patterns of spatially varying selection?

    DEFF Research Database (Denmark)

    Ulrik, Malene G.; Pujolar, Jose Martin

    2014-01-01

    Background: The two North Atlantic eel species, the European and the American eel, represent an ideal system in which to study parallel selection patterns due to their sister species status and the presence of ongoing gene flow. A panel of 80 coding-gene SNPs previously analyzed in American eel was used to genotype European eel individuals (glass eels) from 8 sampling locations across the species distribution. We tested for single-generation signatures of spatially varying selection in European eel by searching for elevated genetic differentiation using F-ST-based outlier tests and by testing for significant associations between allele frequencies and environmental variables. Results: We found signatures of possible selection at a total of 11 coding-gene SNPs. Candidate genes for local selection constituted mainly genes with a major role in metabolism as well as defense genes. Contrary to what has been found for American eel, only 2 SNPs in our study correlated with differences in temperature, which suggests that other explanatory variables may play a role. None of the genes found to be associated with explanatory variables in European eel showed any correlations with environmental factors in the previous study in American eel. Conclusions: The different signatures of selection between species could be due to distinct selective pressures associated with the much longer larval migration for European eel relative to American eel. The lack of parallel selection in North Atlantic eels could also be due to most phenotypic traits being polygenic, thus reducing the likelihood of selection acting on the same genes in both species.

  4. Aluminum phosphate shows more adjuvanticity than Aluminum hydroxide in recombinant hepatitis –B vaccine formulation

    Directory of Open Access Journals (Sweden)

    2008-08-01

    Full Text Available Background: Although a number of investigation have been carried out to find alternative adjuvants to aluminum salts in vaccine formulations, they are still extensively used due to their good track record of safety, low cost and proper adjuvanticity with a variety of antigens. Adsorption of antigens onto aluminum compounds depends heavily on electrostatic forces between adjuvant and antigen. Commercial recombinant protein hepatitis B vaccines containing aluminum hydroxide as adjuvant is facing low induction of immunity in some sections of the vaccinated population. To follow the current global efforts in finding more potent hepatitis B vaccine formulation, adjuvanticity of aluminum phosphate has been compared to aluminum hydroxide. Materials and methods: The adjuvant properties of aluminum hydroxide and aluminum phosphate in a vaccine formulation containing a locally manufactured hepatitis B (HBs surface antigen was evaluated in Balb/C mice. The formulations were administered intra peritoneally (i.p. and the titers of antibody which was induced after 28 days were determined using ELISA technique. The geometric mean of antibody titer (GMT, seroconversion and seroprotection rates, ED50 and relative potency of different formulations were determined. Results: All the adjuvanicity markers obtained in aluminum phosphate formulation were significantly higher than aluminum hydroxide. The geometric mean of antibody titer of aluminum phosphate was approximately three folds more than aluminum hydroxide. Conclusion: Aluminum phosphate showed more adjuvanticity than aluminum hydroxide in hepatitis B vaccine. Therefore the use of aluminum phosphate as adjuvant in this vaccine may lead to higher immunity with longer duration of effects in vaccinated groups.

  5. The galaxy stellar mass function and its evolution with time show no dependence on global environment

    Science.gov (United States)

    Vulcani, B.; Poggianti, B. M.; Oemler, A.; Dressler, A.; Aragón-Salamanca, A.; De Lucia, G.; Moretti, A.; Gladders, M.; Abramson, L.; Halliday, C.

    2013-02-01

    We present an analysis of the galaxy stellar mass function in different environments at intermediate redshift (0.3 ? z ? 0.8) for two mass-limited galaxy samples. We use the IMACS Cluster Building Survey (ICBS; M? ? 1010.5 M?) to study cluster, group and field galaxies at z = 0.3-0.45, and the ESO Distant Cluster Survey (EDisCS; M? ? 1010.2 M?) to investigate cluster and group galaxies at z = 0.4-0.8. Our analysis thus includes galaxies with masses reaching just below that of the Milky Way. Excluding the brightest cluster galaxies, we show that the shape of the mass distribution does not seem to depend on global environment, Our two main results are: (1) Galaxies in the virialised regions of clusters, in groups, and in the field follow similar mass distributions. (2) Comparing the ICBS and EDisCS mass functions to mass functions in the local universe, we detect evolution from z ~ 0.4-0.6 to z ~ 0.07 in the sense that the population of low-mass galaxies has grown with time with respect to the population of massive galaxies. This evolution is independent of environment, i.e., the same for clusters and the field. Furthermore, considering only cluster galaxies, we find that no differences can be detected in their mass functions either within the virialised regions, or when we compare galaxies inside and outside the virial radius. Finally, we find that red and blue galaxies have different mass functions. However, the shapes of the mass functions of blue and red galaxies do not seem to depend on their environment (clusters groups and the field). This paper includes data gathered with the 6.5 m Magellan Telescopes located at Las Campanas Observatory, Chile.

  6. The endoperoxide ascaridol shows strong differential cytotoxicity in nucleotide excision repair-deficient cells

    Energy Technology Data Exchange (ETDEWEB)

    Abbasi, Rashda [Division of Epigenomics and Cancer Risk Factors, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg (Germany); Efferth, Thomas [Institute of Pharmacy und Biochemistry, Johannes Gutenberg University, Staudinger Weg 5, 55128 Mainz (Germany); Kuhmann, Christine [Division of Epigenomics and Cancer Risk Factors, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg (Germany); Opatz, Till [Institute of Organic Chemistry, Johannes Gutenberg University, Duesbergweg 10-14, 55128 Mainz (Germany); Hao, Xiaojiang [Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204 (China); Popanda, Odilia, E-mail: o.popanda@dkfz.de [Division of Epigenomics and Cancer Risk Factors, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg (Germany); Schmezer, Peter [Division of Epigenomics and Cancer Risk Factors, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg (Germany)

    2012-03-15

    Targeting synthetic lethality in DNA repair pathways has become a promising anti-cancer strategy. However little is known about such interactions with regard to the nucleotide excision repair (NER) pathway. Therefore, cell lines with a defect in the NER genes ERCC6 or XPC and their normal counterparts were screened with 53 chemically defined phytochemicals isolated from plants used in traditional Chinese medicine for differential cytotoxic effects. The screening revealed 12 drugs that killed NER-deficient cells more efficiently than proficient cells. Five drugs were further analyzed for IC{sub 50} values, effects on cell cycle distribution, and induction of DNA damage. Ascaridol was the most effective compound with a difference of > 1000-fold in resistance between normal and NER-deficient cells (IC{sub 50} values for cells with deficiency in ERCC6: 0.15 ?M, XPC: 0.18 ?M, and normal cells: > 180 ?M). NER-deficiency combined with ascaridol treatment led to G2/M-phase arrest, an increased percentage of subG1 cells, and a substantially higher DNA damage induction. These results were confirmed in a second set of NER-deficient and -proficient cell lines with isogenic background. Finally, ascaridol was characterized for its ability to generate oxidative DNA damage. The drug led to a dose-dependent increase in intracellular levels of reactive oxygen species at cytotoxic concentrations, but only NER-deficient cells showed a strongly induced amount of 8-oxodG sites. In summary, ascaridol is a cytotoxic and DNA-damaging compound which generates intracellular reactive oxidative intermediates and which selectively affects NER-deficient cells. This could provide a new therapeutic option to treat cancer cells with mutations in NER genes. -- Highlights: ? Thousand-fold higher Ascaridol activity in NER-deficient versus proficient cells. ? Impaired repair of Ascaridol-induced oxidative DNA damage in NER-deficient cells. ? Selective activity of Ascaridol opens new therapy options in NER-deficient tumors.

  7. Empirical analysis shows reduced cost data collection may be an efficient method in economic clinical trials

    Directory of Open Access Journals (Sweden)

    Seidl Hildegard

    2012-09-01

    Full Text Available Abstract Background Data collection for economic evaluation alongside clinical trials is burdensome and cost-intensive. Limiting both the frequency of data collection and recall periods can solve the problem. As a consequence, gaps in survey periods arise and must be filled appropriately. The aims of our study are to assess the validity of incomplete cost data collection and define suitable resource categories. Methods In the randomised KORINNA study, cost data from 234 elderly patients were collected quarterly over a 1-year period. Different strategies for incomplete data collection were compared with complete data collection. The sample size calculation was modified in response to elasticity of variance. Results Resource categories suitable for incomplete data collection were physiotherapy, ambulatory clinic in hospital, medication, consultations, outpatient nursing service and paid household help. Cost estimation from complete and incomplete data collection showed no difference when omitting information from one quarter. When omitting information from two quarters, costs were underestimated by 3.9% to 4.6%. With respect to the observed increased standard deviation, a larger sample size would be required, increased by 3%. Nevertheless, more time was saved than extra time would be required for additional patients. Conclusion Cost data can be collected efficiently by reducing the frequency of data collection. This can be achieved by incomplete data collection for shortened periods or complete data collection by extending recall windows. In our analysis, cost estimates per year for ambulatory healthcare and non-healthcare services in terms of three data collections was as valid and accurate as a four complete data collections. In contrast, data on hospitalisation, rehabilitation stays and care insurance benefits should be collected for the entire target period, using extended recall windows. When applying the method of incomplete data collection, sample size calculation has to be modified because of the increased standard deviation. This approach is suitable to enable economic evaluation with lower costs to both study participants and investigators. Trial registration The trial registration number is ISRCTN02893746

  8. Report on Results 2000

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-07-01

    This report discusses work being carried out in Norway to promote energy efficiency and the production of new renewable energy. An overall review of the quantifiable results of last year's activities at national level is available. It will serve to initiate an annual reporting tradition. The report represents a step towards an ongoing process for improved targeting and management of national efforts. During the course of the year 2000, NVE has evaluated and adjusted its activities and established a system involving indicators and reporting procedures. It is also important to take notice of the long-term work being undertaken to influence people's attitudes, even though this work is difficult to assess. NVE is investing in i.a. measures aimed at children and young people. Apart from directly influencing future energy users, this investment is also having an effect due to the children's encouragement of their parents to engage in more energy and environment-friendly behaviour. Published in 2000, the IEA report ''Trends in Norwegian Stationary Energy Use'' shows that total Norwegian energy consumption per GDP is not much higher than in other IEA countries, when adjusted for cold climate and industrial structure. However, Norwegians do stand out as intensive users of electricity. The IEA report shows a reduction of 10 TWh in energy usage when compared to the projected post 1990 figures. Energy efficiency activities have contributed towards this reduction. However, the potential for a more rational use of energy in Norway is still substantial and well documented. Based on experience most enterprises could save around 10% of energy used just by making changes to their operations, i.e. without major investments. Furthermore, the potential is growing because of massive technological developments in respect of energy usage, production and distribution. With this in mind, it is necessary to take full advantage of the extensive knowledge base regarding new renewable energy sources that is available through Nordic cooperation. During the course of the year a new energy body will be established to assume responsibility for initiatives encouraging more rational energy usage and more environment-friendly energy production. When this energy body commences operations next year, it will have a solid foundation on which to build further. It will inherit a well-founded system and an efficient structure. The results achieved during the year 2000 show savings in energy efficiency and the production of new renewable energy of 720 GWh. The gains could be even greater with clearly defined target-driven management. Due to internationalisation, Norway now has to deal with problems to which little attention was previously paid. All energy production has negative environmental co sequences. It is becoming increasingly obvious that we all need to contribute to limiting the damaging effects, while at the same time the international community needs to take the initiative in harmonizing measures which can result in a more sustainable and environment-friendly direction.

  9. Pat's Prologues: Introductions to the First Two Airings of Math Medley, A Radio Talk Show.

    Science.gov (United States)

    Kenschaft, Patricia Clark

    2002-01-01

    Describes a radio show called "Math Medley" featuring a variety of guests including past presidents of the National Council of Teachers of Mathematics (NCTM), research mathematicians, classroom teachers, and leaders of environmental organizations. Features transcripts of two full introductions to the show. (Author/MM)

  10. Alkaloids from the seeds of Peganum harmala showing antiplasmodial and vasorelaxant activities.

    Science.gov (United States)

    Astulla, Adil; Zaima, Kazumasa; Matsuno, Yosuke; Hirasawa, Yusuke; Ekasari, Wiwied; Widyawaruyanti, Aty; Zaini, Noor Cholies; Morita, Hiroshi

    2008-10-01

    Bioassay-guided purification from the seeds of Peganum harmala led to the isolation of harmine (1), harmaline (2), vasicinone (3), and deoxyvasicinone (4). Harmine (1) and harmaline (2) showed a moderate in vitro antiplasmodial activity against Plasmodium falciparum. Quinazoline alkaloid, vasicinone (3), showed a vasorelaxant activity against phenylephrine-induced contraction of isolated rat aorta. PMID:18523842

  11. Using the "Mary Tyler Moore Show" as a Feminist Teaching Tool

    Science.gov (United States)

    Jule, Allyson

    2010-01-01

    This paper explores the use of "The Mary Tyler Moore Show" as a teaching tool used with a group of final-year undergraduate students who gathered together last academic year (2007-8) to explore Women in Leadership, as part of a Communications course. The research focus was: How can the use of "The Mary Tyler Moore Show" (a 1970-7 American…

  12. Using Journals to Show Students What Social Psychology Is All about

    Science.gov (United States)

    Harrod, Wendy J.

    2009-01-01

    Professional journals serve the vital scientific function of disseminating knowledge to colleagues. In so doing, journals become the "face" and "voice" of the professional disciplines they represent. Journal content shows the major topics of interest, the scope, and the boundaries of the profession. It shows the techniques and methods of research…

  13. Prisoner's Dilemma Applied and in the Classroom: The TV Game Show "Friend or Foe"

    Science.gov (United States)

    Coe, Paul R.; Alonzi, Loreto Peter; Condon, Daniel; Butterworth, William T.

    2007-01-01

    Prisoner's Dilemma is a common game theory scenario in which two players must choose between acting cooperatively or out of pure self-interest. What a player decides affects not only his own outcome but also that of the other player. "Friend or Foe," a TV game show that has appeared on the cable Game Show Network (GSN), places pairs of contestants…

  14. 77 FR 13522 - Safety Zone; Baltimore Air Show, Patapsco River, Baltimore, MD

    Science.gov (United States)

    2012-03-07

    The Coast Guard proposes to establish a temporary safety zone during the ``Baltimore Air Show,'' which consists of aerial practices, performance demonstrations and air shows, to be held over certain waters of the Patapsco River adjacent to the Fort McHenry National Monument and Historic Shrine in Baltimore, Maryland from June 14, 2012 through June 17, 2012. This proposed rule is necessary to......

  15. Guinea pigs showing color inheritance, still imageSite: DNA Interactive (www.dnai.org)

    Science.gov (United States)

    2008-10-06

    DNAi location: Chronicle>Threat of the Unfit>the fit and unfitGuinea pigs showing color inheritance, part of a Fitter Families exhibit, 1926. Fitter Families Contests held at state fairs throughout the United States during the 1920s showed that American eugenicists were literal in their aim to apply principles of agricultural breeding to human beings.

  16. Our Little Land and the Urgency of Showing, Not Telling, Our Subjectivities

    Science.gov (United States)

    Reinertsen, Anne Beate; Otterstad, Ann Merete; Ben-Horin, Oded

    2014-01-01

    This is a collaborative writing story in which songs and poems invite us into complexities of living the ideals and calling for new ways of making the world visible. I need to show you who I am. You need to show me who you are. They are never completed, always open to self and social reflection, and hopefully capable of pushing boundaries of both…

  17. Zoom to Montana Fires Showing SeaWiFS Data and the Landsat-7 Thermal Channel

    Science.gov (United States)

    Michael Mangos

    2000-07-28

    This animation shows the western fires burning in Montana. The initial frame is a SeaWiFS image showing the smoke plume stretching clear across the country. The camera zooms into the source of the fires, flying through the smoke plume, and revealing a composite image of visible and thermal Landsat7 data.

  18. Seismic tomography shows that upwelling beneath Iceland is confined to the upper mantle

    Science.gov (United States)

    Foulger, G. R.; Pritchard, M. J.; Julian, B. R.; Evans, J. R.; Allen, R. M.; Nolet, G.; Morgan, W. J.; Bergsson, B. H.; Erlendsson, P.; Jakobsdottir, S.; Ragnarsson, S.; Stefansson, R.; Vogfjörd, K.

    2001-08-01

    We report the results of the highest-resolution teleseismic tomography study yet performed of the upper mantle beneath Iceland. The experiment used data gathered by the Iceland Hotspot Project, which operated a 35-station network of continuously recording, digital, broad-band seismometers over all of Iceland 1996-1998. The structure of the upper mantle was determined using the ACH damped least-squares method and involved 42 stations, 3159 P-wave, and 1338S-wave arrival times, including the phases P, pP, sP, PP, SP, PcP, PKIKP, pPKIKP, S, sS, SS, SKS and Sdiff. Artefacts, both perceptual and parametric, were minimized by well-tested smoothing techniques involving layer thinning and offset-and-averaging. Resolution is good beneath most of Iceland from ~60km depth to a maximum of ~450km depth and beneath the Tjornes Fracture Zone and near-shore parts of the Reykjanes ridge. The results reveal a coherent, negative wave-speed anomaly with a diameter of 200-250km and anomalies in P-wave speed, VP, as strong as -2.7 per cent and in S-wave speed, VS, as strong as -4.9 per cent. The anomaly extends from the surface to the limit of good resolution at ~450km depth. In the upper ~250km it is centred beneath the eastern part of the Middle Volcanic Zone, coincident with the centre of the ~100mGal Bouguer gravity low over Iceland, and a lower crustal low-velocity zone identified by receiver functions. This is probably the true centre of the Iceland hotspot. In the upper ~200km, the low-wave-speed body extends along the Reykjanes ridge but is sharply truncated beneath the Tjornes Fracture Zone. This suggests that material may flow unimpeded along the Reykjanes ridge from beneath Iceland but is blocked beneath the Tjornes Fracture Zone. The magnitudes of the VP, VS and VP/VS anomalies cannot be explained by elevated temperature alone, but favour a model of maximum temperature anomalies <200K, along with up to ~2 per cent of partial melt in the depth range ~100-300km beneath east-central Iceland. The anomalous body is approximately cylindrical in the top 250km but tabular in shape at greater depth, elongated north-south and generally underlying the spreading plate boundary. Such a morphological change and its relationship to surface rift zones are predicted to occur in convective upwellings driven by basal heating, passive upwelling in response to plate separation and lateral temperature gradients. Although we cannot resolve structure deeper than ~450km, and do not detect a bottom to the anomaly, these models suggest that it extends no deeper than the mantle transition zone. Such models thus suggest a shallow origin for the Iceland hotspot rather than a deep mantle plume, and imply that the hotspot has been located on the spreading ridge in the centre of the north Atlantic for its entire history, and is not fixed relative to other Atlantic hotspots. The results are consistent with recent, regional full-thickness mantle tomography and whole-mantle tomography images that show a strong, low-wave-speed anomaly beneath the Iceland region that is confined to the upper mantle and thus do not require a plume in the lower mantle. Seismic and geochemical observations that are interpreted as indicating a lower mantle, or core-mantle boundary origin for the North Atlantic Igneous Province and the Iceland hotspot should be re-examined to consider whether they are consistent with upper mantle processes.

  19. Surfactant assisted synthesis of Co and Li doped ZnO nanocrystalline samples showing room temperature ferromagnetism

    CERN Document Server

    Jayakumar, D; Kulshreshtha, S K; Jayakumar, onattu D.; Gopalakrishnan, Iyyani K.; Kulshreshtha, Shailendra K.

    2006-01-01

    We have developed a simple, surfactant assisted synthesis route for the preparation, in gram quantities, of Co and Li doped ZnO nanocrystalline samples showing robust room temperature ferromagnetism. Our studies show that RTF is intrinsic to Zn0.85Co0.05Li0.10O and not due to any segregated secondary phases. In addition, it has been shown that the defects play an important role in activating RTF in these oxide systems. This also provide an explanation for the widely varying results observed in the literature. The method can also be extended for the synthesis of other transition metal doped ZnO.

  20. A Physics Show Performed by Students for Kids: From Mechanics to Elementary Particle Physics

    CERN Document Server

    Dreiner, H K

    2007-01-01

    We describe an initiative at the University of Bonn, where the students develop and perform a 2 hour physics show for school classes and the general public. The show is entertaining and educational and is aimed at children aged 10 and older. For the physics students this is a unique experience to apply their knowledge at an early stage and gives them the chance to develop skills in the public presentation of science, in front of 520 people per show. We have extended the activity to put on an elementary particle physics show for teenagers. Furthermore, local high schools have picked up the idea; their students put on similar shows for fellow students and parents. We would be interested in hearing about related activities elsewhere.

  1. Chemistry of springs across the Mariana forearc shows progressive devolatilization of the subducting plate

    Science.gov (United States)

    Mottl, Michael J.; Wheat, C. Geoffrey; Fryer, Patricia; Gharib, Jim; Martin, Jonathan B.

    2004-12-01

    Cold springs upwelling through large serpentinite mud volcanoes in the outer half of the Mariana forearc provide a unique window into processes of devolatilization of the subducting Pacific Plate. We have sampled upwelling pore waters with lower chlorinity than seawater from six sites on five serpentinite mud volcanoes, by conventional gravity and piston coring, by push coring from the ROV Jason, by drilling on ODP Legs 125 and 195, and by manned submersible. The sites range from 13°47'N to 19°33'N and 52 to 90 km from the Mariana trench axis, corresponding to approximate depths to the top of the downgoing plate of 16 to 29 km. The composition of the springs varies systematically over this distance: nearer the trench the upwelling waters have much higher Ca and Sr than seawater and much lower carbonate alkalinity, sulfate, Na/Cl, K, Rb, and B. Farther from the trench the waters show the opposite trends relative to seawater. Chlorinity is consistently lower than in seawater and shows large variations that are not systematic with distance from the trench. Cs is consistently higher than in seawater and increases with distance from the trench. All of the waters have high pH and are heavily depleted in Mg, Si, Li, F, and 87Sr/ 86Sr relative to seawater. They tend to be enriched in O 18/O 16. Except for ODP drilling, none of the cores was long enough to produce an asymptotic compositional trend with depth. We have inferred the end-member compositions of the upwelling waters by extrapolation against Mg. At two sites we were able to compare data from gravity cores with data from drill cores or push cores collected at springs to estimate the effects of reactions that occur at shallow depth below the seafloor, on mixing of the upwelling waters with seawater. These effects are different for sites high in dissolved Ca, nearer the trench, vs. those high in alkalinity, farther from the trench. Common to both are large losses from solution of 1) Ca, as CaCO 3 and in exchange for Na; 2) Mg, in exchange for Na or Ca and as brucite; 3) sulfate, probably reduced by microbes or possibly precipitated as gypsum; 4) Sr, Ba, Si, and F. Na is consistently leached from the solids into solution, whereas K and O 18/O 16 are relatively unreactive. We infer that the upwelling waters are uniformly saturated with CaCO 3 and that the excess H 2O and the trends in Ca, Sr, alkalinity, and sulfate with distance from the trench result from introduction of H 2O and dissolved carbonate and sulfate from an external source, the sediment and altered basalt at the top of the subducting plate. The concurrent trends in Na/Cl, B, Cs, and especially K and Rb indicate that these species originate from the top of the subducting plate in response to increasing temperature. These systematic variations across the outer forearc imply that the solutions ascend more or less vertically from the source region and do not travel long distances laterally along the décollement before ascending. Based on leaching of K, the 150°C isotherm is crossed approximately beneath Big Blue Seamount at a depth of ˜22 km below the seafloor, 70 km behind the trench. By this point it appears that carbonate dissolution has joined dehydration as a significant process at the top of the subducting plate.

  2. HD 51844: An Am ? Scuti in a binary showing periastron brightening

    Science.gov (United States)

    Hareter, M.; Paparó, M.; Weiss, W.; García Hernández, A.; Borkovits, T.; Lampens, P.; Rainer, M.; De Cat, P.; Marcos-Arenal, P.; Vos, J.; Poretti, E.; Baglin, A.; Michel, E.; Baudin, F.; Catala, C.

    2014-07-01

    Context. Pulsating stars in binary systems are ideal laboratories to test stellar evolution and pulsation theory, since a direct, model-independent determination of component masses is possible. The high-precision CoRoT photometry allows a detailed view of the frequency content of pulsating stars, enabling detection of patterns in their distribution. The object HD 51844 is such a case showing periastron brightening instead of eclipses. Aims: We present a comprehensive study of the HD 51844 system, where we derive physical parameters of both components, the pulsation content and frequency patterns. Additionally, we obtain the orbital elements, including masses, and the chemical composition of the stars. Methods: Time series analysis using standard tools was employed to extract the pulsation frequencies. Photospheric abundances of 21 chemical elements were derived by means of spectrum synthesis. We derived orbital elements both by fitting the observed radial velocities and the light curves, and we did asteroseismic modelling as well. Results: We found that HD 51844 is a double lined spectroscopic binary. The determined abundances are consistent with ? Delphini classification. We determined the orbital period (33.498 ± 0.002 d), the eccentricity (0.484 ± 0.020), the mass ratio (0.988 ± 0.02), and the masses to 2.0 ± 0.2 M? for both components. Only one component showed pulsation. Two p modes (f22 and f36) and one g mode (forb) may be tidally excited. Among the 115 frequencies, we detected triplets due to the frequency modulation, frequency differences connected to the orbital period, and unexpected resonances (3:2, 3:5, and 3:4), which is a new discovery for a ? Sct star. The observed frequency differences among the dominant modes suggest a large separation of 2.0-2.2 d-1, which are consistent with models of mean density of 0.063 g cm-3, and with the binary solution and TAMS evolutionary phase for the pulsating component. The binary evolution is in an intermediate evolutionary phase; the stellar rotation is super-synchronised, but circularisation of the orbit is not reached. Based on observations obtained with the HERMES spectrograph attached to the Mercator Telescope which is operated on the island of La Palma by the University of Leuven (IvS) at the Spanish Observatorio del Roque de los Muchachos of the Instituto de Astrofísica de Canarias. The HERMES spectrograph is supported by the Fund for Scientific Research of Flanders (FWO), Belgium, the Research Council of K.U. Leuven, Belgium, the Fonds National de la Recherche Scientifique (FNRS), Belgium, the Royal Observatory of Belgium, the Observatoire de Genève, Switzerland and the Thüringer Landessternwarte Tautenburg, Germany. Based on CoRoT space-based photometric data; the CoRoT space mission was developed and operated by the French space agency CNES, with the participation of ESA's RSSD and Science Programmes, Austria, Belgium, Brazil, Germany, and Spain. Based on observations collected at La Silla Observatory, ESO (Chile) with the HARPS spectrograph at the 3.6 m telescope, under programme LP185.D-0056.Table 9 is available in electronic form at http://www.aanda.org

  3. The wildgeographer avatar shows how to measure soil erosion rates by means of a rainfall simulator

    Science.gov (United States)

    Cerdà, Artemi; González Pelayo, Óscar; Pereira, Paulo; Novara, Agata; Iserloh, Thomas; Prosdocimi, Massimo

    2015-04-01

    This contribution to the immersed worlds wish to develop the avatar that will teach the students and other scientists how to develop measurements of soil erosion, surface runoff and wetting fronts by means of simulated rainfall experiments. Rainfall simulation is a well established and knows methodology to measure the soil erosion rates and soil hydrology under controlled conditions (Cerdà 1998a; Cerdà, 1998b; Cerdà and Jurgensen, 2011; Dunkerley, 2012; Iserloh et al., 2012; Iserloh et al., 2013; Ziadat and Taimeh, 2013; Butzen et al., 2014). However, is a method that requires a long training and expertise to avoid mismanagement and mistaken. To use and avatar can help in the teaching of the technique and the dissemination of the findings. This contribution will show to other avatars how to develop an experiment with simulated rainfall and will help to take the right decision in the design of the experiments. Following the main parts of the experiments and measurements the Wildgeographer avatar must develop: 1. Determine the objectives and decide which rainfall intensity and distribution, and which plot size to be used. Choose between a laboratory or a field rainfall simulation. 2. Design of the rainfall simulator to achieve the objectives: type of rainfall simulator (sprayer or drop former) and calibrate. 3. The experiments are carried out. 4. The results are show. Acknowledgements To the "Ministerio de Economía and Competitividad" of Spanish Government for finance the POSTFIRE project (CGL2013- 47862-C2-1-R). The research projects GL2008-02879/BTE, LEDDRA 243857 and PREVENTING AND REMEDIATING DEGRADATION OF SOILS IN EUROPE THROUGH LAND CARE (RECARE)FP7-ENV-2013- supported this research. References Butzen, V., Seeger, M., Wirtz, S., Huemann, M., Mueller, C., Casper, M., Ries, J. B. 2014. Quantification of Hortonian overland flow generation and soil erosion in a Central European low mountain range using rainfall experiments. Catena, 113, 202-212. Cerdà, A. 1998a. Effect of climate on surface flow along a climatological gradient in Israel. A field rainfall simulation approach. Journal of Arid Environments, 38, 145-159. Cerdà, A. 1998b. The influence of aspect and vegetation on seasonal changes in erosion under rainfall simulation on a clay soil in Spain. Canadian Journal of Soil Science, 78, 321-330. Cerdà, A., Jurgensen, M. F. 2011. Ant mounds as a source of sediment on citrus orchard plantations in eastern Spain. A three-scale rainfall simulation approach. Catena, 85(3), 231-236. Dunkerley, D. 2012. Effects of rainfall intensity fluctuations on infiltration and runoff: rainfall simulation on dryland soils, Fowlers Gap, Australia. Hydrological Processes, 26(15), 2211-2224. Iserloh, T., Ries, J.B., Arnaez, J., Boix Fayos, C., Butzen, V., Cerdà, A., Echeverría, M.T., Fernández-Gálvez, J., Fister, W., Geißler, C., Gómez, J.A., Gómez-Macpherson, H., Kuhn, N.J., Lázaro, R., León, F.J., Martínez-Mena, M., Martínez-Murillo, J.F., Marzen, M., Mingorance, M.D., Ortigosa, L., Peters, P., Regüés, D., Ruiz-Sinoga, J.D., Scholten, T., Seeger, M., Solé-Benet, A., Wengel, R., Wirtz, S. 2013. European small portable rainfall simulators: a comparison of rainfall characteristics. Catena, 110, 100-112. Doi: 10.1016/j.catena.2013.05.013 Iserloh, T., Ries, J.B., Cerdà, A., Echeverría, M.T., Fister, W., Geißler, C., Kuhn, N.J., León, F.J., Peters, P., Schindewolf, M., Schmidt, J., Scholten, T., Seeger, M. (2012): Comparative measurements with seven rainfall simulators on uniform bare fallow land. Zeitschrift für Geomorphologie, 57, 193-201. DOI: 10.1127/0372- 8854/2012/S-00118. Ziadat, F. M., Taimeh, A. Y. 2013. Effect of rainfall intensity, slope and land use and antecedent soil moisture on soil erosion in an arid environment. Land Degradation & Development, 24: 582- 590. DOI 10.1002/ldr.2239

  4. Areva - 2011 Annual results

    International Nuclear Information System (INIS)

    Areva's backlog established at 45.6 billion euros at the end of 2011, significantly increasing at the end of a year marked by the Fukushima accident, confirms the commercial dynamism of the group alongside its customers and reinforces the visibility on its future business level. In a difficult context, the slight decline in revenue in 2011 demonstrates the robustness of Areva's integrated model, resting mainly on recurring business generated in relation to Areva's customers' nuclear installed base, and benefiting from the development of Areva's renewable energies operations. Free operating cash flow before tax, although down over the whole year in 2011, improved in the second half, showing the first effects of Areva's stronger focus on cash generation and debt management. After the success of Areva's bond issue in September 2011, the Group's liquidity remains high at the end of 2011. The Areva teams are now dedicating all of their efforts to the deployment of the 'Action 2016' strategic action plan, which had already yielded its first positive results at the end of 2011, with an improvement in the cost structure of Areva's operations, an increase in order intake, and the launch of several disposals of minority interests. Summary of the 2011 financial results: - Backlog: euro 45.6 bn, +3.1% vs. 2010, i.e +6.7% over 3 months; - Revenue: euro 8.872 bn, i.e -2.6% vs. 2010; - Operating income: - euro 1.923 bn; - Net income attributable to equity owners of the parent: - euro 2.424 bn; - EBITDA: euro 1.068 bn ( euro 420 m excluding Siemens impact); - Free operating cash flow before tax: - euro 2.397 bn (- euro 1.366 bn excluding Siemens impacts), improvement over the second half; - Decrease in net debt of euro 124 m for the year; - Significant drop in general and administrative expenses, with a noticeable reduction between the first and the second half; - Launch of several disposals of minority interests

  5. Authenticity Through Cooperation of the Host and the Guests in a Chinese TV Talk Show

    Directory of Open Access Journals (Sweden)

    Xiao-mei ZHOU

    2008-03-01

    Full Text Available TV talk shows have always been the focus of attention in mass media studies from the perspective of discourse analysis. Many studies are centered on how the hosts and guests achieve their respective authenticity. What remains largely unexplored is how the hosts and guests cooperate to construct authenticity for the talk show. By focusing on the cooperative nature of the relationship between the hosts and the guests in the realization of this authenticity intended by the talk show Behind The Headlines With Wen Tao, this paper explores the content and form to demonstrate how the talk show successfully provides news information and entertains the audience in a genuine sense through cooperation strategies.
    Key words: talk show, authenticity, cooperation
    Résumé: Le talk show est depuis longtemps le foyer d’attention dans l’étude des mass médias dans la perspective de l’analyse du discours. Beaucoup des recherches sont centrées sur comment les animateurs et les invités accomplissent leur authenticité respective. Ce qui reste largement exploré, c’est comment les animateurs et les invités coopèrent pour construire l’authenticité du programme. En concentrant sur la nature coopérative de la relation entre les animateurs et les invités dans la réalisation de cette authenticité attendue par le programme de talk show Derrière le gros titre avec Wen Tao, le présent article explore le contenu et la forme afin de démontrer comment le talk show offre avec succès de nouvelles informations et entretient l’audience avec des stratégies de coopération.
    Mots-Clés: talk show, authenticité, coopération
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  6. The Transcriptional Heat Shock Response of Salmonella Typhimurium Shows Hysteresis and Heated Cells Show Increased Resistance to Heat and Acid Stress

    DEFF Research Database (Denmark)

    Pin, C.; Hansen, Trine

    2012-01-01

    We investigated if the transcriptional response of Salmonella Typhimurium to temperature and acid variations was hysteretic, i.e. whether the transcriptional regulation caused by environmental stimuli showed memory and remained after the stimuli ceased. The transcriptional activity of non-replicating stationary phase cells of S. Typhimurium caused by the exposure to 45uC and to pH 5 for 30 min was monitored by microarray hybridizations at the end of the treatment period as well as immediately and 30 minutes after conditions were set back to their initial values, 25uC and pH 7. One hundred and two out of 120 up-regulated genes during the heat shock remained up-regulated 30 minutes after the temperature was set back to 25uC, while only 86 out of 293 down regulated genes remained down regulated 30 minutes after the heat shock ceased. Thus, the majority of the induced genes exhibited hysteresis, i.e., they remained up-regulated after the environmental stress ceased. At 25uC the transcriptional regulation of genesencoding for heat shock proteins was determined by the previous environment. Gene networks constructed with up-regulated genes were significantly more modular than those of down-regulated genes, implying that down-regulation was significantly less synchronized than upregulation. The hysteretic transcriptional response to heat shock was accompanied by higher resistance to inactivation at 50uC as well as cross-resistance to inactivation at pH 3; however, growth rates and lag times at 43uC and at pH 4.5 were not affected. The exposure to pH 5 only caused up-regulation of 12 genes and this response was neither hysteretic nor accompanied of increased resistance to inactivation conditions. Cellular memory at the transcriptional level may represent a mechanism of adaptation to the environment and a deterministic source of variability in gene regulation.

  7. Media Framing of Sports Competitions. Going Beyond the War and the Show Frames of Sports Events

    OpenAIRE

    Dumitriu, Diana Luiza

    2012-01-01

    As an interdisciplinary field, sports activate and re-contextualize a wide repertoire of symbolic elements, among which war nand show ethos seem to be the most prominent. The aim of this study is to go beyond the "war" and the "show" frames duality and to discuss the emergenceof a new hybrid construct: the sports war-show. Based on a discourse analysis of textual and visual units – images and their corollary captions, the study outlines the way in which media frame an international sports e...

  8. Study of KIC 8561221 observed by Kepler: an early red giant showing depressed dipolar modes

    DEFF Research Database (Denmark)

    García, R. A.; Pérez Hernández, F.

    2014-01-01

    Context. The continuous high-precision photometric observations provided by the CoRoT and Kepler space missions have allowed us to understand the structure and dynamics of red giants better using asteroseismic techniques. A small fraction of these stars show dipole modes with unexpectedly low amplitudes. The reduction in amplitude is more pronounced for stars with a higher frequency of maximum power, ?max. Aims: In this work we want to characterise KIC 8561221 in order to confirm that it is currently the least evolved star among this peculiar subset and to discuss several hypotheses that could help explain the reduction of the dipole mode amplitudes. Methods: We used Kepler short- and long-cadence data combined with spectroscopic observations to infer the stellar structure and dynamics of KIC 8561221. We then discussed different scenarios that could contribute to reducing the dipole amplitudes, such as a fast-rotating interior or the effect of a magnetic field on the properties of the modes. We also performed a detailed study of the inertia and damping of the modes. Results: We have been able to characterise 36 oscillations modes, in particular, a few dipole modes above ?max that exhibit nearly normal amplitudes. The frequencies of all the measured modes were used to determine the overall properties and the internal structure of the star. We have inferred a surface rotation period of ~91 days and uncovered a variation in the surface magnetic activity during the last 4 years. The analysis of the convective background did not reveal any difference compared to "normal" red giants. As expected, the internal regions of the star probed by the ? = 2 and 3 modes spin 4 to 8 times faster than the surface. Conclusions: With our grid of standard models we are able to properly fit the observed frequencies. Our model calculation of mode inertia and damping give no explanation for the depressed dipole modes. A fast-rotating core is also ruled out as a possible explanation. Finally, we do not have any observational evidenceof a strong deep magnetic field inside the star. Table 3 and Appendix A are available in electronic form at http://www.aanda.org

  9. Repeated injections of 131I-rituximab show patient-specific stable biodistribution and tissue kinetics

    International Nuclear Information System (INIS)

    It is generally assumed that the biodistribution and pharmacokinetics of radiolabelled antibodies remain similar between dosimetric and therapeutic injections in radioimmunotherapy. However, circulation half-lives of unlabelled rituximab have been reported to increase progressively after the weekly injections of standard therapy doses. The aim of this study was to evaluate the evolution of the pharmacokinetics of repeated 131I-rituximab injections during treatment with unlabelled rituximab in patients with non-Hodgkin's lymphoma (NHL). Patients received standard weekly therapy with rituximab (375 mg/m2) for 4 weeks and a fifth injection at 7 or 8 weeks. Each patient had three additional injections of 185 MBq 131I-rituximab in either treatment weeks 1, 3 and 7 (two patients) or weeks 2, 4 and 8 (two patients). The 12 radiolabelled antibody injections were followed by three whole-body (WB) scintigraphic studies during 1 week and blood sampling on the same occasions. Additional WB scans were performed after 2 and 4 weeks post 131I-rituximab injection prior to the second and third injections, respectively. A single exponential radioactivity decrease for WB, liver, spleen, kidneys and heart was observed. Biodistribution and half-lives were patient specific, and without significant change after the second or third injection compared with the first one. Blood T1/2?, calculated from the sequential blood samples and fitteom the sequential blood samples and fitted to a bi-exponential curve, was similar to the T1/2 of heart and liver but shorter than that of WB and kidneys. Effective radiation dose calculated from attenuation-corrected WB scans and blood using Mirdose3.1 was 0.53+0.05 mSv/MBq (range 0.48-0.59 mSv/MBq). Radiation dose was highest for spleen and kidneys, followed by heart and liver. These results show that the biodistribution and tissue kinetics of 131I-rituximab, while specific to each patient, remained constant during unlabelled antibody therapy. RIT radiation doses can therefore be reliably extrapolated from a preceding dosimetry study. (orig.)

  10. Showing no spot sign is a strong predictor of independent living after intracerebral haemorrhage

    DEFF Research Database (Denmark)

    Havsteen, Inger; Ovesen, Christian

    2014-01-01

    BACKGROUND: A spot sign on computed tomography angiography (CTA) is a potentially strong predictor of poor outcome on ultra-early radiological imaging. The aim of this study was to assess the spot sign as a predictor of functional outcome at 3 months as well as long-term mortality, with a focus on the ability to identify patients with a spontaneous, acceptable outcome. METHODS: In a prospective, consecutive single-centre registry of acute stroke patients, we investigated patients with spontaneous intracerebral haemorrhage (ICH) admitted within 4.5 h after symptom onset from April 2009 to January 2013. The standard work-up in our centre included CTA for spot sign status, unless a contraindication was present. Modified Rankin Scale (mRS) scores were assessed at 3 months in the outpatient clinic or by telephone interviews. Long-term mortality was assessed by electronic chart follow-up for up to 1,500 days. RESULTS: Of the 128 patients, 37 (28.9%) had a spot sign on admission CTA. The presence of a spot sign was associated with larger median admission haematoma volume [38.0 ml (IQR 18.0-78.0) vs. 12.0 ml (5.0-24.0); p<0.0001] and higher median National Institutes of Health Stroke Scale score [19 (IQR 12-23) vs. 12 (6-16); p<0.0001]. Three months after stroke, the median functional outcome was considerably better in patients without spot sign [mRS score 3 (IQR 2-4) vs. 6 (4-6); p<0.0001]. The absence of a spot sign showed a sensitivity and specificity for good outcome (mRS scores 0-2) of 0.91 and 0.36, respectively. The presence of a spot sign was, in multivariate models, an independent inverse predictor of good 3-month outcome (OR 0.17; 95% CI: 0.03-0.88) as well as a prominent independent predictor of poor 3-month outcome (mRS scores 5-6; OR 3.40; 95% CI: 1.10-10.5) and death during follow-up (HR 3.04; 95% CI: 1.45-6.34). Patients with a spot sign surviving the acute phase had long-term survival comparable to patients with no spot sign. CONCLUSION: The absence or presence of a spot sign is a reliable ultra-early predictor of long-term mortality and functional outcome in patients with spontaneous ICH.

  11. Deficit irrigation scheduling based on plant growth stages showing water stress tolerance

    International Nuclear Information System (INIS)

    With increasing municipal and industrial demands for water, its allocation for agriculture is decreasing steadily. The major agricultural use of water is for irrigation, which, thus, is affected by decreased supply. Therefore, innovations are needed to increase the efficiency of use of the water that is available. There are several possible approaches. Irrigation technologies and irrigation scheduling may be adapted for more-effective and rational uses of limited supplies of water. Drip and sprinkler irrigation methods are preferable to less efficient traditional surface methods. It is necessary to develop new irrigation scheduling approaches, not necessarily based on full crop water requirement, but ones designed to ensure the optimal use of allocated water. Deficit (or regulated deficit) irrigation is one way of maximizing water use efficiency (WUE) for higher yields per unit of irrigation water applied: the crop is exposed to a certain level of water stress either during a particular period or throughout the whole growing season. The expectation is that any yield reduction will be insignificant compared with the benefits gained through diverting the saved water to irrigate other crops. The grower must have prior knowledge of crop yield responses to deficit irrigation. This paper reviews yield responses of major field crops to deficit irrigation, including cotton, maize, potato, sugar cane, soybean and wheat. Crop yields obtained under various levels of reduced evapained under various levels of reduced evapotranspiration were fitted to the linear crop yield response functions of Stewart et al. (1977). Results show that cotton, maize, wheat, sunflower, sugar beet and potato are well suited to deficit irrigation practices, with reduced evapotranspiration imposed throughout the growing season. This list may also include common bean, groundnut, soybean and sugar cane where reduced evapotranspiration is limited to (a) certain growth stage(s). With a 25 percent deficit, WUE was 1.2 times that achieved under normal irrigation practices. Irrigation scheduling based on deficit irrigation requires careful evaluation to ensure enhanced efficiency of use of increasingly scarce supplies of irrigation water. (author)

  12. The benefit of symbols: monkeys show linear, human-like, accuracy when using symbols to represent scalar value.

    Science.gov (United States)

    Livingstone, Margaret S; Srihasam, Krishna; Morocz, Istvan A

    2010-09-01

    When humans and animals estimate numbers of items, their error rate is proportional to the number. To date, however, only humans show the capacity to represent large numbers symbolically, which endows them with increased precision, especially for large numbers, and with tools for manipulating numbers. This ability depends critically on our capacity to acquire and represent explicit symbols. Here we show that when rhesus monkeys are trained to use an explicit symbol system, they too show more precise, and linear, scaling than they do using a one-to-one corresponding numerosity representation. We also found that when taught two different types of representations for reward amount, the monkeys systematically undervalued the less precise representation. The results indicate that monkeys, like humans, can learn alternative mechanisms for representing a single value scale and that performance variability and relative value depend on the distinguishability of each representation. PMID:20443126

  13. New method for rearing Spodoptera frugiperda in laboratory shows that larval cannibalism is not obligatory

    Scientific Electronic Library Online (English)

    Cherre Sade Bezerra Da, Silva; José Roberto Postali, Parra.

    2013-09-01

    Full Text Available New method for rearing Spodoptera frugiperda in laboratory shows that larval cannibalism is not obligatory. Here we show, for the first time, that larvae of the fall armyworm (FAW), Spodoptera frugiperda (Lepidoptera, Noctuidae), can be successfully reared in a cohort-based manner with virtually no [...] cannibalism. FAW larvae were reared since the second instar to pupation in rectangular plastic containers containing 40 individuals with a surprisingly ca. 90% larval survivorship. Adult females from the cohort-based method showed fecundity similar to that already reported on literature for larvae reared individually, and fertility higher than 99%, with the advantage of combining economy of time, space and material resources. These findings suggest that the factors affecting cannibalism of FAW larvae in laboratory rearings need to be reevaluated, whilst the new technique also show potential to increase the efficiency of both small and mass FAW rearings.

  14. Case Western research shows PET imaging effective in predicting lung cancer outcomes:

    Science.gov (United States)

    Advanced imaging with Positron Emission Tomography (PET) scans shows great promise in predicting which patients with inoperable lung cancer have more aggressive tumors and need additional treatment following standard chemotherapy/radiation therapy, according to new research.

  15. 77 FR 22523 - Safety Zone; 2012 Ocean City Air Show; Atlantic Ocean, Ocean City, MD

    Science.gov (United States)

    2012-04-16

    ...SECURITY Coast Guard 33 CFR Part 165 [Docket No. USCG-2012-0189] RIN 1625-AA00 Safety Zone; 2012 Ocean City Air Show; Atlantic Ocean, Ocean City, MD AGENCY: Coast Guard, DHS. ACTION: Notice of proposed...

  16. 75 FR 18778 - Safety Zone; Ocean City Air Show 2010, Atlantic Ocean, Ocean City, MD

    Science.gov (United States)

    2010-04-13

    ...SECURITY Coast Guard 33 CFR Part 165 [Docket No. USCG-2010-0153] RIN 1625-AA00 Safety Zone; Ocean City Air Show 2010, Atlantic Ocean, Ocean City, MD AGENCY: Coast Guard, DHS. ACTION: Notice of proposed...

  17. 25 CFR 26.33 - How do I show I need job training?

    Science.gov (United States)

    2010-04-01

    ...DEPARTMENT OF THE INTERIOR HUMAN SERVICES JOB PLACEMENT AND TRAINING PROGRAM Training Services § 26.33 How do I show I need job training? The need for Job Placement and Training is shown by completing an...

  18. Novel Drug Delivery System Shows Early Promise for Treating Lupus in Mice

    Science.gov (United States)

    ... System Shows Early Promise for Treating Lupus in Mice A drug delivery system using nanoparticle technology that ... administered the MPA-loaded nanogel to lupus-prone mice that had not yet developed symptoms of the ...

  19. Many Acne Patients Don't Take Their Meds, Survey Shows

    Science.gov (United States)

    ... nih.gov/medlineplus/news/fullstory_151585.html Many Acne Patients Don't Take Their Meds, Survey Shows ... 2015 FRIDAY, March 20, 2015 (HealthDay News) -- Many acne patients do not take all their recommended medications, ...

  20. Group photo to show NASA GRC's collaboration with Goodyear tires; The facility is called the

    Science.gov (United States)

    2007-01-01

    Group photo to show NASA GRC's collaboration with Goodyear tires; The facility is called the Simulated Lunar Operations (SLOPE) Laboratory and the test-vehicle is called Modular Mobility-Technology Demonstrator (MMTD)

  1. Newly developed foam ceramic body shows promise as thermal insulation material at 3000 deg F

    Science.gov (United States)

    Blocker, E. W.; Paul, R. D.

    1967-01-01

    Optimized zirconia foam ceramic body shows promise for use as a thermal insulation material. The insulating media displays low density and thermal conductivity, good thermal shock resistance, high melting point, and mechanical strength.

  2. CMS experiment : animation showing the construction of the main structural components of CMS together

    CERN Multimedia

    CERN Multimedia Production Unit

    2003-01-01

    This 17-minute long animation shows the construction of the main structural components of CMS in the surface hall in Cessy and offers a detailed overview of the installation in the experimental cavern.

  3. Left and right brain-oriented hemisity subjects show opposite behavioral preferences

    Directory of Open Access Journals (Sweden)

    BruceEldineMorton

    2012-11-01

    Conclusions: The right and left brain-oriented hemisity subtype subjects, sorted on the anatomical basis of upon which brain side their vgACC was thickest, showed numerous significant differences in their “either-or” type of behavioral preferences.

  4. SeaWiFS Galapagos Island Zoom Showing Before and During El Nino

    Science.gov (United States)

    Greg Shirah

    1998-01-01

    SeaWiFS Galapagos Island Zoom Showing phytoplankton concentrations before and during El Nino. There is lots of phytoplankton prior to El Ninos warm waters, but once the warm waters dominate the area, most of the phytoplankton disappear.

  5. A case showing a blistering disorder in radiation dermatitis during radiation therapy

    International Nuclear Information System (INIS)

    We experienced a case showing a blistering disorder in radiation dermatitis during radiation therapy for thymic cancer. Application of steroid to the lesion improved blisters. The literature on bullous eruption including radiation-induced bullous pemhigoid was critically reviewed. (author)

  6. Antinomias do zoológico humano: sociabilidade selvagem, reality shows e regressão da consciência

    Directory of Open Access Journals (Sweden)

    Francisco Rüdiger

    2008-11-01

    Full Text Available Estuda-se no artigo as articulações ideológicas e sentido histórico dos chamados reality shows na sociedade brasileira contemporânea. Em primeiro, situamos o gênero numa perspectiva histórica, sublinhado suas raí­zes religiosas e populares em conexão com a formação do sistema de poder próprio do Ocidente. Depois, expõem-se alguns aspectos do fenômeno, chamando atenção para sua estrutura interna e seu sentido concreto em nossa organização societária, com base nas suas versões brasileiras. Em terceiro, focamos os textos nas relações de poder que se articulam por meio desses programas, discutindo algumas das várias teorizações a seu respeito. Adiante e continuando a recorrer a matérias de imprensa, procede-se a um julgamento dessas últimas, visando propor uma interpretação histórica de seu significado. A conclusão retorna ao marco inicial e oferece uma visão geral em que talvez se possa pensar melhor o que está em jogo nos reality shows. Palavras-chave reality shows no Brasil, programas de televisão, sociabilidade Abstract This article analyses the ideological connections and historical meaning of the so-called reality shows in the contemporary Brazillian society. At first, we locate this genre in a historical perspective, stressing its religious and popular roots but also the connections between it and the power systems that have built Western World. Secondly, the text expose the main features of this kind of television show, calling attention to its inner structure but also to its meaning in our social organization, making critical remarks about their Brazillian versions. Focusing on the power relations that are articulated in it, we discuss some theories made about them. The historical meaning of these shows in our present circumstances is projected in the fourth stage of the article, that explores some materials extracted from the press. Finally, we return to the larger historical context and offer a general interpretation to think these programs in it. Key words brazillian reality shows, television shows, sociability

  7. 77 FR 27123 - Safety Zone; Baltimore Air Show, Patapsco River, Baltimore, MD

    Science.gov (United States)

    2012-05-09

    The Coast Guard is establishing a temporary safety zone during the ``Baltimore Air Show'', which consists of aerial practices, performance demonstrations and air shows, to be held over certain waters of the Patapsco River adjacent to the Fort McHenry National Monument and Historic Shrine in Baltimore, Maryland from June 14, 2012 through June 17, 2012. This rule is necessary to provide for the......

  8. Opphos - a participative light and sound show using mobile phones in crowds

    OpenAIRE

    Marfisi-schottman, Iza; Karlsson, Gunnar; Celander Guss, Jonas

    2013-01-01

    Opphos is a mobile application that creates participative light and sound shows by using and coordinating the screens and speakers of smartphones of people in crowds. These shows are made up of waves of color and sound that are generated by the cheers and movements of the participants. Opphos is built on a peer-to-peer network middleware that provides communication between mobile phones in large crowds, where standard cellular networks would not be available or sufficient.

  9. The Brazilian experience shows that voters are more forgiving of incompetence than they are of corruption

    OpenAIRE

    Weitz-Shapiro, Rebecca; Winters, Matthew S.

    2013-01-01

    Corruption in the UK is perceived as being on the rise, with recent research showing that British citizens are increasingly concerned about the relationship between private financial interests and politicians. But are voters willing to forgive corrupt politicians if they are competent? New research which looks at the Brazilian case by Rebecca Weitz-Shapiro and Matthew S. Winters shows that voters are merciless when it comes to forgiving corrupt officials and politicians, and that the...

  10. Acoustic emission measurements for showing of thermal shock cracks on a cladded steel plate

    International Nuclear Information System (INIS)

    Acoustic emission measurements were made on a cladded steel plate which was loaded on three points by several thousand thermal shocks. While the nondestructive testing with ultrasonic, eddy current and dye penetrant showed no flaw indications, the acoustic emission testing located two regions with higher event rates. The destructive testing of the plate showed cracks of 0,1 to 1 mm depth in this region. (orig.)

  11. All-inorganic core-shell silica-titania mesoporous colloidal nanoparticles showing orthogonal functionality

    OpenAIRE

    Cauda, Valentina; Szeifert, Johann M.; Merk, Karin; Fattakhova-Rohlfing, Dina; Bein, Thomas

    2011-01-01

    Colloidal mesoporous silica (CMS) nanoparticles with a thin titania-enriched outer shell showing a spatially resolved functionality were synthesized by a delayed co-condensation approach. The titaniashell can serve as a selective nucleation site for the growth of nanocrystalline anatase clusters. These fully inorganic pure silica-core titania-enriched shell mesoporous nanoparticles show orthogonal functionality, demonstrated through the selective adsorption of a carboxylate-contai...

  12. Political Tv Talk Shows on Greek Television: Live Broadcasting as an ideological and Cognitive frame

    OpenAIRE

    Ioanna Vovou

    2007-01-01

    This paper presents a semiopragmatic analysis of the political talk shows on Greek television that reveals a symbolic conception of the TV studio and it’s value-attributing mechanisms through which principles of democratic dialogue are enacted inside this kind of social and media frame. Political talk shows create the notion of a complex temporality, larger than the concept of events presented live, afecting the political and social vision of the audience.

  13. Some Examples to Show that Objects be Presented by Mathematical Equations

    OpenAIRE

    The Minh Tran

    2012-01-01

    We have often heard remarks such as “We can plot graphs from the mathematical equations”, including equations of lines, equations of curves, and equations of invisible and visible objects. Actually, we can present each object by mathematical equation and we can plot graphs from equations. Equations not only show visible objects but also can show invisible objects such as wave equations in differential equations. In fact, the change of equations is also to conduce the change of objects and...

  14. "Tormenta Espacial" - Exploring The Sun-earth Connection With A Spanish-language Planetarium Show

    Science.gov (United States)

    Elteto, Attila; Salas, F.; Duncan, D.; Traub-Metlay, S.

    2007-10-01

    Reaching out to Spanish speakers is increasingly vital to workforce development and public support of space science projects. Building on a successful partnership with NASA's TIMED mission, LASP and Space Science Institute, Fiske Planetarium has translated its original planetarium show - "Space Storm” - into "Tormenta Espacial". This show explores the Sun-Earth connection and explains how solar activity affects technology and life on Earth. Solar scientists from NOAA's Space Environment Center and the University of Colorado at Boulder contributed to provide scientific accuracy. Show content and accompanying educational materials are aligned with state and national science standards. While designed for students in grades 6-8, this show has been positively evaluated by students from grades 4-10 and shown to the general public with favorable responses. Curricular materials extend the planetarium experience into the K-12 classroom so that students inspired and engaged by the show continue to see real-life applications and workplace opportunities. Fiske Planetarium offers both "Space Storm” and "Tormenta Espacial” to other planetariums at a minimal rate, including technical support for the life of the show. Thanks to a request from a planetarium in Belgium, a version of "Space Storm” is available with no spoken dialogue so that languages other than English or Spanish may be accommodated. Collaborative projects among planetariums, NASA missions (planned as well as active), research scientists and other parties keep EPO activities healthy and well-funded. Fiske Planetarium staff strive to develop and maintain partnerships throughout the EPO and informal education communities.

  15. Viral Reverse Transcriptases Show Selective High Affinity Binding to DNA-DNA Primer-Templates that Resemble the Polypurine Tract

    OpenAIRE

    Nair, Gauri R.; Dash, Chandravanu; Le Grice, Stuart F. J; DeStefano, Jeffrey J

    2012-01-01

    Previous results using a SELEX (Systematic Evolution of Ligands by Exponential Enrichment)-based approach that selected DNA primer-template duplexes binding with high affinity to HIV reverse transcriptase (RT) showed that primers mimicking the 3? end, and in particular the six nt terminal G tract, of the RNA polypurine tract (PPT; HIV PPT: 5?-AAAAGAAAAGGGGGG-3?) were preferentially selected. In this report, two viral (Moloney murine leukemia virus (MuLV) and avian myeloblastosis virus (...

  16. Coadministration of doxorubicin and etoposide loaded in camel milk phospholipids liposomes showed increased antitumor activity in a murine model.

    Science.gov (United States)

    Maswadeh, Hamzah M; Aljarbou, Ahmed N; Alorainy, Mohammed S; Rahmani, Arshad H; Khan, Masood A

    2015-01-01

    Small unilamellar vesicles from camel milk phospholipids (CML) mixture or from 1,2 dipalmitoyl-sn-glycero-3-phosphatidylcholine (DPPC) were prepared, and anticancer drugs doxorubicin (Dox) or etoposide (ETP) were loaded. Liposomal formulations were used against fibrosarcoma in a murine model. Results showed a very high percentage of Dox encapsulation (~98%) in liposomes (Lip) prepared from CML-Lip or DPPC-Lip, whereas the percentage of encapsulations of ETP was on the lower side, 22% of CML-Lip and 18% for DPPC-Lip. Differential scanning calorimetry curves show that Dox enhances the lamellar formation in CML-Lip, whereas ETP enhances the nonlamellar formation. Differential scanning calorimetry curves also showed that the presence of Dox and ETP together into DPPC-Lip produced the interdigitation effect. The in vivo anticancer activity of liposomal formulations of Dox or ETP or a combination of both was assessed against benzopyrene (BAP)-induced fibrosarcoma in a murine model. Tumor-bearing mice treated with a combination of Dox and ETP loaded into CML-Lip showed increased survival and reduced tumor growth compared to other groups, including the combination of Dox and ETP in DPPC-Lip. Fibrosarcoma-bearing mice treated with a combination of free (Dox + ETP) showed much higher tumor growth compared to those groups treated with CML-Lip-(Dox + ETP) or DPPC-Lip-(Dox + ETP). Immunohistochemical study was also performed to show the expression of tumor-suppressor PTEN, and it was found that the tumor tissues from the group of mice treated with a combination of free (Dox + ETP) showed greater loss of cytoplasmic PTEN than tumor tissues obtained from the groups of mice treated with CML-Lip-(Dox + ETP) or DPPC-Lip-(Dox + ETP). PMID:25926730

  17. Coadministration of doxorubicin and etoposide loaded in camel milk phospholipids liposomes showed increased antitumor activity in a murine model

    Science.gov (United States)

    Maswadeh, Hamzah M; Aljarbou, Ahmed N; Alorainy, Mohammed S; Rahmani, Arshad H; Khan, Masood A

    2015-01-01

    Small unilamellar vesicles from camel milk phospholipids (CML) mixture or from 1,2 dipalmitoyl-sn-glycero-3-phosphatidylcholine (DPPC) were prepared, and anticancer drugs doxorubicin (Dox) or etoposide (ETP) were loaded. Liposomal formulations were used against fibrosarcoma in a murine model. Results showed a very high percentage of Dox encapsulation (~98%) in liposomes (Lip) prepared from CML-Lip or DPPC-Lip, whereas the percentage of encapsulations of ETP was on the lower side, 22% of CML-Lip and 18% for DPPC-Lip. Differential scanning calorimetry curves show that Dox enhances the lamellar formation in CML-Lip, whereas ETP enhances the nonlamellar formation. Differential scanning calorimetry curves also showed that the presence of Dox and ETP together into DPPC-Lip produced the interdigitation effect. The in vivo anticancer activity of liposomal formulations of Dox or ETP or a combination of both was assessed against benzopyrene (BAP)-induced fibrosarcoma in a murine model. Tumor-bearing mice treated with a combination of Dox and ETP loaded into CML-Lip showed increased survival and reduced tumor growth compared to other groups, including the combination of Dox and ETP in DPPC-Lip. Fibrosarcoma-bearing mice treated with a combination of free (Dox + ETP) showed much higher tumor growth compared to those groups treated with CML-Lip-(Dox + ETP) or DPPC-Lip-(Dox + ETP). Immunohistochemical study was also performed to show the expression of tumor-suppressor PTEN, and it was found that the tumor tissues from the group of mice treated with a combination of free (Dox + ETP) showed greater loss of cytoplasmic PTEN than tumor tissues obtained from the groups of mice treated with CML-Lip-(Dox + ETP) or DPPC-Lip-(Dox + ETP). PMID:25926730

  18. Show-Bix & : En anti re-enactment af et arkiv med performativ mediekunst

    DEFF Research Database (Denmark)

    The anti-reenactment 'Show-Bix &' consists of 5 dias projectors, a dial phone, quintophonic sound, and interactive elements. A responsive interface will enable the Dias projectors to show copies of original dias slides from the Show-Bix piece ”March på Stedet”, 265 images in total. The copies are made from digital scans of the original dias slides located in the collection of the Museum of Contemporary Art in Roskilde. In front of the audience entering the space and placed on it’s own stand, is an original 60s style telephone with turning dial. Action begins when the audience lift the phone and dial a number. Any number will make the Dias change. All numbers are also assigned to specific sound documents: clips form rare interviews and the complete sound-re-enactment of the Show-Bix piece ‘Omringning’ (‘Surrounding’) in five channels (a quintophonie). This was originally produced in collaboration with Per Højholt and Gunner Møller Pedersen for the 2004 show on Per Højholt in Roskilde.

  19. On the measurement of fatigue crack growth rates of steels using non-standard specimens

    International Nuclear Information System (INIS)

    Fatigue crack growth rates were measured using K-Decreasing Method during precracking of standard (Compact Tension) and non-standard (Charpy V -notch and Three-Point-Bend) specimens of four ferritic steels. Crack growth rates from the specimens were then inter-compared. The results from Compact Tension specimens were within ±15% error bar of the results from Three-Point-Bend specimens and were within ±6% error bar of the results from Charpy V -notch. The inter-comparison of the mean crack growth rates of any of the steels as obtained using different specimen geometries did not reveal any systematic dependence of crack growth rates vis-a-vis the specimens utilized. The experimental results suggested the possibility of generating material crack growth rate data as a bonus during fatigue precracking of fracture toughness specimens including Charpy V-notch and Three-Point-Bend specimens. The results also indicated distinct possibility of the measurement of steady state fatigue crack growth rate of irradiated steels using either Compact Tension and Three-Point-Bend fracture toughness specimens with a/W ? 0.65 or during precrackingstep of a few designated impact specimens from surveillance locations to be used as fracture toughness specimens for generation of irradiated material fracture toughness data. (author)

  20. A simple identification method for spore-forming bacteria showing high resistance against ?-rays

    International Nuclear Information System (INIS)

    A simple identification method was developed for spore-forming bacteria which are highly resistant against ?-rays. Among 23 species of Bacillus studied, the spores of Bacillus megaterium, B. cereus, B. thuringiensis, B. pumilus and B. aneurinolyticus showed high resistance against ?-rays as compared with other spores of Bacillus species. Combination of the seven kinds of biochemical tests, namely, the citrate utilization test, nitrate reduction test, starch hydrolysis test, Voges-Proskauer reaction test, gelatine hydrolysis test, mannitol utilization test and xylose utilization test showed a characteristic pattern for each species of Bacillus. The combination pattern of each the above tests with a few supplementary test, if necessary, was useful to identify Bacillus species showing high radiation resistance against ?-rays. The method is specific for B. megaterium, B. thuringiensis and B. pumilus, and highly selective for B. aneurinolyticus and B. cereus. (author)

  1. Some Examples to Show that Objects be Presented by Mathematical Equations

    Directory of Open Access Journals (Sweden)

    The Minh Tran

    2012-09-01

    Full Text Available We have often heard remarks such as “We can plot graphs from the mathematical equations”, including equations of lines, equations of curves, and equations of invisible and visible objects. Actually, we can present each object by mathematical equation and we can plot graphs from equations. Equations not only show visible objects but also can show invisible objects such as wave equations in differential equations. In fact, the change of equations is also to conduce the change of objects and phenomena. This paper presents mathematical equations, methods to plot the graphs in 2D and 3D space. The paper is also a small proof of this conclusion have been provided and addressing visualization problem for any object. The novelty of this paper presents some special equations of objects and shows the ideas to build objects from equations.

  2. The Structure and Properties of Diffusion Assisted Bonded Joints in 17-4 PH, Type 347, 15-5 PH and Nitronic 40 Stainless Steels

    Science.gov (United States)

    Wigley, D. A.

    1981-01-01

    Diffusion assisted bonds are formed in 17-4 PH, 15-5 PH, type 347 and Nitronic 40 stainless steels using electrodeposited copper as the bonding agent. The bonds are analyzed by conventional metallographic, electron microprobe analysis, and scanning electron microscopic techniques as well as Charpy V-notch impact tests at temperatures of 77 and 300 K. Results are discussed in terms of a postulated model for the bonding process.

  3. Cocktails of human anti-cancer antibodies show a synergistic effect in nude mouse tumor xenografts.

    Science.gov (United States)

    Glassy, Mark C; McKnight, Michael E; Kotlan, Beatrix; Glassy, Eric F; Koda, Keiji

    2007-01-01

    A panel of four natural human monoclonal IgG antibodies derived from B lymphocytes isolated from regional draining lymph nodes of cancer patients has been developed and characterized. The four human antibodies are termed, RM1, RM2, RM3, and RM4. The immunoreactivity of this panel of four human antibodies is restricted to tumor cells. Individually, these human MAbs show tumor targeting and are effective in inhibiting tumor growth in nude mouse xenograft models. When used in combination the antibodies show an additive effect in slowing down the progression of tumors in xenograft models suggesting that cocktails of antibodies may be useful in the clinic. PMID:18334744

  4. Petrographic evidence shows that pottery exchange between the Olmec and their neighbors was two-way

    Science.gov (United States)

    Stoltman, James B.; Marcus, Joyce; Flannery, Kent V.; Burton, James H.; Moyle, Robert G.

    2005-01-01

    Petrographic thin sections of pottery from five Formative Mexican archaeological sites show that exchanges of vessels between highland and lowland chiefly centers were reciprocal, or two-way. These analyses contradict recent claims that the Gulf Coast was the sole source of pottery carved with iconographic motifs. Those claims were based on neutron activation, which, by relying on chemical elements rather than actual minerals, has important limitations in its ability to identify nonlocal pottery from within large data sets. Petrography shows that the ceramics in question (and hence their carved motifs) have multiple origins and were widely traded. PMID:16061796

  5. Nanoscale E-Cadherin ligand patterns show threshold size for cellular adhesion and adherence junction formation

    DEFF Research Database (Denmark)

    Kristensen, Stine H; Pedersen, Gitte Albinus

    2012-01-01

    The role of ligand spatial distribution on the formation of cadherin mediated cell-cell contacts is studied utilizing nanopatterns of E-cadherin ligands. Protein patches ranging in size from 100 nm to 800 nm prepared by colloidal lithography critically influence adhesion, spreading and formation of adherence junctions in epithelial cells. Cells at 100 nm patterns show poor adhesion, while larger pattern sizes show both good adhesion, significant spreading and defined cortical actin. We estimate a threshold of 0.03?m2 for epithelial cellular attachment via E-Cadherin

  6. Radon awareness in Ireland: a assessment of the effectiveness of radon road shows

    International Nuclear Information System (INIS)

    Full text: In late 2004 the Radiological Protection Institute of Ireland (R.P.I.I.) initiated a series of radon road shows in areas designated as High Radon Areas 1 in the R.P.I.I. s national radon survey of homes. The main objective of these road shows was to provide information to a local audience on the risks of exposure to radon. These road shows target both employers and householders. Each road show has the same general format. A presentation and/or meeting with a major employer representative group within the area. The purpose is to make employers aware of the risks associated with exposure to radon in the workplace and to highlight their obligations under current Irish health and safety legislation regarding radon in the workplace. An information stand on radon manned by R.P.I.I. staff members in a local shopping centre or other similar area. This provides those concerned about radon with accessible information on radon exposure risks, how to measure radon and the steps a home owner could take to reduce radon concentrations where necessary. Where possible R.P.I.I. staff members visit one or more schools in the general area. A short presentation on radon was given to students and students were given an opportunity to asks questions Maximizing media exposure to publicize our visits is vital to the success of these visits. Each visit is preceded by a Press Release whose main aim is to brief local and national media on the radon issue so as to achieve maximum publicity mainly through radio and television coverage. In general the media are very interested in the whole radon area and R.P.I.I. staff members have given 57 radio and 10 television interviews to date since the commencement of this initiative. The four road shows carried out to date have been successful in encouraging householders to carry out radon measurements. Since the start of the road shows to the present, the R.P.I.I. has seen a 44% increase in the number of householders requesting radon measurements compared to the corresponding period of the previous year. However the road shows have been less successful in encouraging employers to measure radon with similar numbers of employers measuring radon during both these periods. It is anticipated that these radon road shows will continue during 2006. (author)

  7. A humanized anti-M2 scFv shows protective in vitro activity against influenza

    Energy Technology Data Exchange (ETDEWEB)

    Bradbury, Andrew M [Los Alamos National Laboratory; Velappan, Nileena [Los Alamos National Laboratory; Schmidt, Jurgen G [Los Alamos National Laboratory

    2008-01-01

    M2 is one of the most conserved influenza proteins, and has been widely prospected as a potential universal vaccine target, with protection predominantly mediated by antibodies. In this paper we describe the creation of a humanized single chain Fv from 14C2, a potent monoclonal antibody against M2. We show that the humanized scFv demonstrates similar activity to the parental mAb: it is able to recognize M2 in its native context on cell surfaces and is able to show protective in vitro activity against influenza, and so represents a potential lead antibody candidate for universal prophylactic or therapeutic intervention in influenza.

  8. The Construction of National Memory Through Popular Culture. The Case of the Argentinian TV Show,

    Directory of Open Access Journals (Sweden)

    Elizondo Oviedo, María Verónica

    2010-07-01

    Full Text Available This article addresses the borders of the complex television sign through the analysis of the Argentinian TV show "Peter Capusotto y sus videos". In it we find that humor is used as a mechanism to dismantle binary hierarchic political and social oppositions. The program is presented as a musical and comedy TV show where concepts such as popular culture and mass culture are questioned through different false musicians. We focus our attention in the character of Bombita Rodríguez, el Palito Ortega montonero due to the controversy generated in the cultural scene by the fact of bringing up recent aspects of Argentinian history.

  9. Show Me Stars: Engaging celebrities in astronomy outreach with their Twitter followers

    Science.gov (United States)

    Gomez, E.

    2014-01-01

    The Las Cumbres Observatory Global Telescope Network (LCOGT1) has telescopes in locations around the globe that are used daily by scientists and by the general public. In a new LCOGT outreach initiative called Show Me Stars, celebrities were chosen as guest hosts for a series of Twitter-based observing events using a 2-metre robotic telescope. The celebrities made tweets throughout their one-hour online observing sessions using the hashtag "#ShowMeStars", with the aim of engaging large pools of Twitter followers in astronomy.

  10. Anti-plane problem analysis for icosahedral quasicrystals under shear loadings

    Science.gov (United States)

    Li, Wu; Chai, Yu-Zhen

    2014-11-01

    The present paper is concerned with the longitudinal shear elasticity of three-dimensional icosahedral quasicrystals. By virtue of the Dugdale hypothesis along with the method of complex potential theory, it involves two defect problems of the icosahedral quasicrystals. The first one is the calculation of stress intensity factors and the size of the cohesive force zone in a half-infinite crack. Meanwhile, the crack tip tearing displacements can be exactly derived. The other is the demonstration of the generalized stress intensity factors induced by a sharp V-notch as an extension of a crack. The generalized E-integral around the notch tip gives the energy release rate when the V-notch degenerates into a crack. Apart from their own usefulness in carrying out some simplified crack analyses, the results obtained in this work can particularly serve as a basis for fracture mechanics of anti-plane defect problems of icosahedral quasicrystals.

  11. Obesity-resistant S5B rats showed great cocaine conditioned place preference than the obesity-prone OM rats

    Energy Technology Data Exchange (ETDEWEB)

    Thanos, P.K.; Wang, G.; Thanos, P.K..; Kim, R.; Cho, J.; Michaelides, M.; Anderson, B.J.; Primeaux, S.D.; Bray, G.A.; Wang, G.-J.; Robinson, J.K.; Volkow, N.D.

    2010-12-01

    Dopamine (DA) and the DA D2 receptor (D2R) are involved in the rewarding and conditioned responses to food and drug rewards. Osborne-Mendel (OM) rats are genetically prone and S5B/P rats are genetically resistant to obesity when fed a high-fat diet. We hypothesized that the differential sensitivity of these two rat strains to natural rewards may also be reflected in sensitivity to drugs of abuse. Therefore, we tested whether OM and S5B/P rats showed a differential preference to cocaine using conditioned place preference (CPP). To also evaluate whether there is specific involvement of the D2R in this differential conditioning sensitivity, we then tested whether the D2R agonist bromocriptine (BC) would differentially affect the effects of cocaine in the two strains. OM and S5B/P rats were conditioned with cocaine (5 or 10 mg/kg) in one chamber and saline in another for 8 days. Rats were then tested for cocaine preference. The effects of BC (0.5, 1, 5, 10, 20 mg/kg) on cocaine preference were then assessed in subsequent test sessions. OM rats did not show a significant preference for the cocaine-paired chamber on test day. Only the S5B/P rats showed cocaine CPP. Later treatment with only the highest dose of BC resulted in reduced cocaine CPP in S5B/P rats when treated with 5 mg/kg cocaine and in OM rats treated with 10 mg/kg cocaine. Our results indicated that obesity-resistant S5B rats showed greater cocaine CPP than the obesity-prone OM rats. These findings do not support a theory of common vulnerability for reinforcer preferences (food and cocaine). However, they show that BC reduced cocaine conditioning effects supporting at least a partial regulatory role of D2R in conditioned responses to drugs.

  12. Hepatic scar in a case of healed candidiasis showing prolonged enhancement on CT

    Energy Technology Data Exchange (ETDEWEB)

    Itai, Yuji; Yashiro, Naobumi

    1987-08-01

    A patient with acute myelocytic leukemia recovering from hepatic candidiasis after long-term administration of amphotericin B had large scar in the liver which showed prominent prolonged enhancement on postcontrast CT. Prolonged enhancement can occur in regions other than hepatic masses.

  13. An unusual intracardiac electrogram showing cause for false electrical discharge from an ICD.

    Science.gov (United States)

    Mohammed, Ishaq; Ratib, Karim; Creamer, John

    2013-01-01

    We describe a rare case of inappropriate implantable cardioverter defibrillator (ICD) therapy due to false sensing of electromechanical interference from diathermy as 'ventricular fibrillation (VF)'. This occurred during surgical removal of sternal wires under general anaesthesia. Postsurgical interrogation of ICD revealed the intracardiac electrogram showing the mechanical interference sensed as 'VF' by ICD and subsequent shock delivery. PMID:23912653

  14. LHC collision event at CMS showing four high energy muons (CMS Higgs search)

    CERN Multimedia

    CMS Collaboration

    2011-01-01

    11sec animation of a Higgs->ZZ->4mu candidate being created CMS . Real CMS proton-proton collision events in which 4 high energy muons (light blue lines) are observed. The event shows characteristics expected from the decay of a Higgs boson but is also consistent with background Standard Model physics processes.

  15. Entropy Shows that Global Warming Should Cause Increased Variability in the Weather

    OpenAIRE

    Williams, John Michael

    2000-01-01

    Elementary physical reasoning seems to leave it inevitable that global warming would increase the variability of the weather. The first two terms in an approximation to the global entropy are used to show that global warming has increased the free energy available to drive the weather, and that the variance of the weather should increase correspondingly.

  16. Correlation analyses between volatiles and glucosinolates show no evidence for chemical defense signaling in Brassica rapa

    Directory of Open Access Journals (Sweden)

    FlorianPaulSchiestl

    2014-04-01

    Full Text Available Positive correlations between volatile organic compounds (VOCs and defense chemicals indicate signaling of defense status. Such aposematic signaling has been hypothesized to be widespread in plants, however, it has up to now only been shown for visual signals. Correlations between identical compounds in different plant tissues, on the other hand, can be informative about the (co-regulation of their biosynthesis or emission. Here I use Brassica rapa to investigate 1 correlations between identical metabolites (volatiles, glucosinolates in leaf and flower tissue, and 2 correlations between volatiles and glucosinolates in the same plant organs (flowers and leaves. Whereas the amounts of many glucosinolates were positively correlated in leaves and flower tissue, identical leaf and floral VOCs showed no such correlations, indicating independent regulation of emission. None of the leaf or flower volatiles showed positive correlations with the two major glucosinolates (gluconapin, glucobrassicanapin or the sum of all glucosinolates in either leaves or flowers. Some VOCs, however, showed positive correlations with minor glucosinolates which, however, represented less than one percent of the total amounts of glucosinolates. Some leaf monoterpenes showed negative associations with gluconapin. The lack of consistent positive correlations between VOCs and major defense compounds suggests that plants do not chemically signal their defense status. This could be adaptive as it may avoid eavesdropping by specialist herbivores to locate their host plants. Negative correlations likely indicate chemical trade-offs in the synthesis of secondary metabolites.

  17. LHC collision event at CMS showing two high energy photons (CMS Higgs search)

    CERN Multimedia

    CMS Collaboration

    2011-01-01

    11sec animation of a Higgs->GammaGamma candidate in CMS. Real CMS proton-proton collision events in which two high energy photons (dashed orange lines and towers) are observed. The event shows characteristics expected from the decay of a Higgs boson but is also consistent with background Standard Model physics processes.

  18. LHC collision event at CMS showing four high energy electrons (CMS Higgs search)

    CERN Multimedia

    CMS Collaboration

    2011-01-01

    11sec animation of a Higgs->ZZ->4e candidate in CMS. Real CMS proton-proton collision events in which 4 high energy electrons (orange lines and towers) are observed. The event shows characteristics expected from the decay of a Higgs boson but is also consistent with background Standard Model physics processes.

  19. Intertextuality as a means of positioning in a talk-show.

    Czech Academy of Sciences Publication Activity Database

    ?mejrková, Sv?tla; Hoffmannová, Jana

    Amsterdam : Benjamins, 2012 - (Lorda, C.; Zabalbeascoa, P.), s. 161-172 ISBN 978-90-272-1032-6. - (Dialogue Studies. 15) R&D Projects: GA ?R GA405/09/2028 Institutional research plan: CEZ:AV0Z90610518 Keywords : positioning * intertextuality * talk-show * reported speech Subject RIV: AI - Linguistics

  20. Molecular epidemiology of Candida isolates from AIDS patients showing different fluconazole resistance profiles.

    OpenAIRE

    Lischewski, A; Ruhnke, M; Tennagen, I; Schönian, G.; Morschhäuser, J.; Hacker, J

    1995-01-01

    Thirty Candida isolates obtained from the oropharynxes of three AIDS patients were genotypically characterized. In vitro fluconazole MIC determination revealed increasing fluconazole resistances during treatment, thereby confirming the in vivo situation. Pulsed-field gel electrophoresis karyotyping, randomly amplified polymorphic DNA analysis, and hybridizations with Candida albicans repetitive element 2 were used to determine possible genotypic changes. The isolates from two patients showed ...

  1. Assessing the "Rothstein Falsification Test": Does It Really Show Teacher Value-Added Models Are Biased?

    Science.gov (United States)

    Goldhaber, Dan; Chaplin, Duncan Dunbar

    2015-01-01

    In an influential paper, Jesse Rothstein (2010) shows that standard value-added models (VAMs) suggest implausible and large future teacher effects on past student achievement. This is the basis of a falsification test that "appears" to indicate bias in typical VAM estimates of teacher contributions to student learning on standardized…

  2. Sauerbraten, Rotkappchen und Goethe: The Quiz Show as an Introduction to German Studies.

    Science.gov (United States)

    White, Diane

    1980-01-01

    Proposes an adaptation of the quiz-show format for classroom use, discussing a set of rules and sample questions designed for beginning and intermediate German students. Presents questions based on German life and culture which are especially selected to encourage participation from students majoring in subjects other than German. (MES)

  3. 20 CFR 416.1826 - Showing that you are not married when you apply for SSI.

    Science.gov (United States)

    2010-04-01

    ...unnecessary. If you do not live with an unrelated...to prove that your marriage has ended you must...rents the place where you live? (v) Do any deeds...married to the person you live with unless the information...section, all considered together, show that the two...

  4. A Case of Vulval Extramammary Paget Disease With Dermal Invasion Showing Mucinous Carcinoma.

    Science.gov (United States)

    Asaka, Shiho; Yoshizawa, Akihiko; Sano, Kenji; Uhara, Hisashi; Honda, Takayuki; Ota, Hiroyoshi

    2015-07-01

    We report a case of vulval extramammary Paget disease (EMPD) with dermal invasion showing mucinous carcinoma (MC). An 80-year-old woman presented with vulvar itching and pain. A physical examination showed a pigmented vulvar, perianal erythematous plague, and a subcutaneous nodule in the left major labia. No internal malignancy, such as colorectal or genitourinary carcinoma, was identified in any of the clinical examinations. A histological examination of the resected specimen revealed Pagetoid tumor cells that had spread widely through the epidermis and invaded the dermis forming a solid nest with mucous lake-like MC. Immunohistochemical examination revealed that the tumor cells in the epidermis and dermis were positive for CK7, CEA, GCDFP-15, MUC5AC, and MUC2, but negative for CK20, MUC6, and CDX2. Only the invasive component showed overexpression of p53. A diagnosis of primary EMPD with dermal invasion showing MC of the vulva was made. This is an extremely rare diagnosis, and we suggest that immunohistochemical evaluations in addition to systemic work-ups are helpful in distinguishing between these cases and those involving vulvar or perianal skin invasion of underlying colorectal or genitourinary carcinomas, which are referred to as secondary EMPD. PMID:25851708

  5. Dr. James McGee shows three astronauts how to handle non-poisonous snake

    Science.gov (United States)

    1967-01-01

    Dr. James W. McGee (right), Medical Operations Office, Manned Spacecraft Center, shows three astronauts how to handle a non-poisonous snake during desert survival training in Washington state. Left to right, are Astronauts Thomas K. Mattingly, Alfred M. Worden, and John L. Swigert Jr.; and Dr. McGee. The astronauts are dressed in faked Arab clothing.

  6. Prezentace kultury a jejích p?edstavitel? v ?eských televizních talk-show.

    Czech Academy of Sciences Publication Activity Database

    Hoffmannová, Jana

    Bratislava : Univerzita Komenského, 2011 - (Orgo?ová, O.), s. 106-115 ISBN 978-80-223-2942-2. [Jazyk a komunikácia v súvislostiach /3./. Bratislava (SK), 08.09.2010-09.09.2010] R&D Projects: GA ?R GA405/09/2028 Institutional research plan: CEZ:AV0Z90610518 Keywords : talk show * communication strategies * Czech Subject RIV: AI - Linguistics

  7. Project WIN Evaluation Shows Decreased Violence and Improved Conflict Resolution Skills for Middle School Students

    Science.gov (United States)

    Laura Roberts

    2007-01-01

    A conflict resolution program, entitled Project WIN: Working out Integrated Negotiations, was piloted in a low-income, urban middle school in southeast Pennsylvania. The evaluation showed the program decreased reported violence and increased students' abilities to apply conflict resolution tools in hypothetical conflict situations.

  8. Five-Year-Olds Can Show the Self-Reference Advantage

    Science.gov (United States)

    Sui, Jie; Zhu, Ying

    2005-01-01

    The current study developed a new paradigm to determine the age at which children begin to show the self-reference advantage in memory. Four-, 5-, and 10-year-olds studied lists of colourful object pictures presented together with self or other face image, and participants were asked to report aloud "who is pointing at the (object)." Then…

  9. 77 FR 50019 - Safety Zone; Cocoa Beach Air Show, Atlantic Ocean, Cocoa Beach, FL

    Science.gov (United States)

    2012-08-20

    ...USCG-2012-0633] RIN 1625-AA00 Safety Zone; Cocoa Beach Air Show, Atlantic Ocean, Cocoa Beach, FL AGENCY: Coast Guard, DHS. ACTION...the waters of the Atlantic Ocean located east of Cocoa Beach, Florida during the Cocoa Beach Air...

  10. Teaching Prospect Theory with the "Deal or No Deal" Game Show

    Science.gov (United States)

    Baker, Ardith; Bittner, Teresa; Makrigeorgis, Christos; Johnson, Gloria; Haefner, Joseph

    2010-01-01

    Recent evidence indicates that decision makers are more sensitive to potential losses than gains. Loss aversion psychology has led behavioural economists to look beyond expected utility by developing "prospect theory." We demonstrate this theory using the "Deal or No Deal" game show.

  11. Studying the Effect of a Competitive Game Show in a Learning by Teaching Environment

    Science.gov (United States)

    Matsuda, Noboru; Yarzebinski, Evelyn; Keiser, Victoria; Raizada, Rohan; Stylianides, Gabriel J.; Koedinger, Kenneth R.

    2013-01-01

    In this paper we investigate how competition among tutees in the context of learning by teaching affects tutors' engagement as well as tutor learning. We conducted this investigation by incorporating a competitive Game Show feature into an online learning environment where students learn to solve algebraic equations by teaching a synthetic…

  12. Northwest Corner of Puerto Rico Showing Shallow Waters and Coral Reefs

    Science.gov (United States)

    Jesse Allen

    1999-04-09

    This scene shows the southwestern corner of the island of Puerto Rico as seen by the three Landsat Thematic Mapper (TM) visible light sensors. The detectors have a limited ability to see through shallow water, detecting the coral reefs and shallow sand areas around the edge of the island.

  13. A SYMBOLIC REALITY OF AMERICAN TELEVISION: A CASE STUDY OF THE JERRY SPRINGER SHOW

    Directory of Open Access Journals (Sweden)

    Ida Rochani Adi

    2006-06-01

    Full Text Available The Jerry Springer Show adalah salah satu program talk show televisi Amerika yang dapat dikategorikan sebagai tabloid talk show, trash talk show, atau istilah lain yang menunjukkan betapa acara ini menyajikan topik persoalan yang vulgar. Meskipun acara ini adalah acara yang banyak dianggap orang tidak layak ditonton, ini masih tetap diminati di Amerika terbukti masih berlangsung dan telah menyajikan lebih dari 3.000 episode. Ternyata acara ini tidak hanya diminati oleh orang Amerika, tetapi juga oleh orang Inggris karena acara ini pun sampai mengilhami pembuatan opera yang dipentaskan di beberapa teater Inggris. Ada tiga realitas yang sebetulnya merupakan simbolisasi yang dapat dimaknai di sini. Pertama, bermoral tidaknya suatu acara tidaklah menentukan minat orang dalam menonton tayangan televisi karena berhasil tidaknya suatu acara dalam masyarakat tergantung dari kekuatan sosial acara tersebut. Kedua, makin tinggi nilai kebebasan suatu masyarakat, makin tinggi pula tuntutan masyarakat terhadap pemenuhan kepuasan penonton televisi. Ketiga, karya imajiner yang ditayangkan di televisi akan dianggap sebagai suatu kebenaran apabila dikemas dalam program yang diterima dalam masyarakat sebagai program informasi dan bukan hiburan meskipun kandungan di dalamnya adalah hiburan.

  14. The Papaya Y Chromosome Evolved Recently and Shows Gene Paucity and DNA Sequence Expansion

    Science.gov (United States)

    Sex chromosomes in flowering plants, in contrast to those in animals, evolved relatively recently and only a few are heteromorphic. At cytological level, the sex chromosomes of papaya appear homomorphic, nevertheless, we are finding the papaya Y chromosome shows features of incipient sex chromosome ...

  15. 76 FR 31235 - Safety Zone; Ocean City Air Show, Atlantic Ocean, Ocean City, MD

    Science.gov (United States)

    2011-05-31

    ...there have been unfortunate instances of jet and plane crashes during performances at air shows. Typical of jet or plane crashes, there is also a wide...can be contacted on VHF-FM marine band radio, channel 13 (156.65 MHz) and...

  16. Grey('s) Identity: Complications of Learning and Becoming in a Popular Television Show

    Science.gov (United States)

    Jubas, Kaela

    2013-01-01

    In this article, the author outlines an analysis of the American show "Grey's Anatomy" as an example of how popular culture represents identity and the process of professional identity construction in a medical workplace, particularly the surgical service of a large urban hospital. In discussing identity, she connects professional identity to…

  17. Caveolin-1-deficient mice are lean, resistant to diet-induced obesity, and show hypertriglyceridemia with adipocyte abnormalities.

    Science.gov (United States)

    Razani, Babak; Combs, Terry P; Wang, Xiao Bo; Frank, Philippe G; Park, David S; Russell, Robert G; Li, Maomi; Tang, Baiyu; Jelicks, Linda A; Scherer, Philipp E; Lisanti, Michael P

    2002-03-01

    Caveolae organelles and caveolin-1 protein expression are most abundant in adipocytes and endothelial cells. Our initial report on mice lacking caveolin-1 (Cav-1) demonstrated a loss of caveolae and perturbations in endothelial cell function. More recently, however, observation of the Cav-1-deficient cohorts into old age revealed significantly lower body weights, as compared with wild-type controls. These results suggest that Cav-1 null mice may have problems with lipid metabolism and/or adipocyte functioning. To test this hypothesis directly, we placed a cohort of wild-type and Cav-1 null mice on a high fat diet. Interestingly, despite being hyperphagic, Cav-1 null mice show overt resistance to diet-induced obesity. As predicted, adipocytes from Cav-1 null null mice lack caveolae membranes. Early on, a lack of caveolin-1 selectively affects only the female mammary gland fat pad and results in a near complete ablation of the hypo-dermal fat layer. There are also indications of generalized adipose tissue pathology. With increasing age, a systemic decompensation in lipid accumulation occurs resulting in dramatically smaller fat pads, histologically reduced adipocyte cell diameter, and a poorly differentiated/hypercellular white adipose parenchyma. To gain mechanistic insights into this phenotype, we show that, although serum insulin, glucose, and cholesterol levels are entirely normal, Cav-1 null mice have severely elevated triglyceride and free fatty acid levels, especially in the post-prandial state. However, this build-up of triglyceride-rich chylomicrons/very low density lipoproteins is not due to perturbed lipoprotein lipase activity, a major culprit of isolated hypertriglyceridemia. The lean body phenotype and metabolic defects observed in Cav-1 null mice are consistent with the previously proposed functions of caveolin-1 and caveolae in adipocytes. Our results show for the first time a clear role for caveolins in systemic lipid homeostasis in vivo and place caveolin-1/caveolae as major factors in hyperlipidemias and obesity. PMID:11739396

  18. A pilot study in non-human primates shows no adverse response to intravenous injection of quantum dots

    Science.gov (United States)

    Ye, Ling; Yong, Ken-Tye; Liu, Liwei; Roy, Indrajit; Hu, Rui; Zhu, Jing; Cai, Hongxing; Law, Wing-Cheung; Liu, Jianwei; Wang, Kai; Liu, Jing; Liu, Yaqian; Hu, Yazhuo; Zhang, Xihe; Swihart, Mark T.; Prasad, Paras N.

    2012-07-01

    Quantum dots have been used in biomedical research for imaging, diagnostics and sensing purposes. However, concerns over the cytotoxicity of their heavy metal constituents and conflicting results from in vitro and small animal toxicity studies have limited their translation towards clinical applications. Here, we show in a pilot study that rhesus macaques injected with phospholipid micelle-encapsulated CdSe/CdS/ZnS quantum dots do not exhibit evidence of toxicity. Blood and biochemical markers remained within normal ranges following treatment, and histology of major organs after 90 days showed no abnormalities. Our results show that acute toxicity of these quantum dots in vivo can be minimal. However, chemical analysis revealed that most of the initial dose of cadmium remained in the liver, spleen and kidneys after 90 days. This means that the breakdown and clearance of quantum dots is quite slow, suggesting that longer-term studies will be required to determine the ultimate fate of these heavy metals and the impact of their persistence in primates.

  19. Contesting the “Nature” Of Conformity: What Milgram and Zimbardo's Studies Really Show

    OpenAIRE

    Haslam, S. Alexander; Reicher, Stephen D.

    2012-01-01

    A re-analysis of classic psychology studies suggests that tyranny does not result from blind conformity to rules and roles, but may involve identification with authorities who represent vicious acts as virtuous.

  20. USGS Map Service Showing Petroleum Resource Potential GIS of Northern Afghanistan

    U.S. Geological Survey, Department of the Interior — This map service includes energy related datasets presenting the results of a petroleum resource assessment of Northern Afghanistan, and other data used in the...