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1

Effects of V-notch dimensions on charpy impact test results for differently sized miniature specimens of ferritic steel  

International Nuclear Information System (INIS)

In order to develop the small specimen technology in Charpy impact testing, the effects of V-notch dimensions on the test results were investigated for miniaturized specimens of a ferritic steel, Japanese Ferrite/Martensite Dual Phase Steel (JFMS). The miniaturized Charpy specimens had four different square cross-sections of 3.3, 2, 1.5 and 1 mm, and each of them had a variety of V-notch dimensions (notch depth, notch root radius and notch angle). All of the specimens were subjected to Charpy impact tests between 93 and 373 K using a specially instrumented impact machine. The fracture surfaces of all tested specimens were examined by scanning electron microscopy. The main results obtained are as follows: (1) The ductile-to-brittle transition temperature (DBTT) varied noticeably depending upon the notch dimensions, some of the DBTTs exceeding that of the full size specimens. (2) The DBTTs for the miniaturized specimens were uniquely defined by the elastic stress concentration factor, Kt, leading to an important aspect that the DBTT for the full size specimens can be directly obtained from the DBTT of the miniaturized specimens with a V-notch giving a suitable value of Kt. (3) The upper shelf energy (USE) was dependent only on notch depth or ligament size, indicating that the notch geometry was practically unimportant. When all of the measured USEs were normalized by Bb2 or (Bb)3/2 (B is the specimen thickness, b the ligament is the specimen thickness, b the ligament size), the normalized USEs of the miniaturized specimens agreed with that of the full size specimens within the range of ±15% except for one specimen whose notch root radius was as large as 0.25 mm. (4) The observed characteristics of fracture surface were essentially the same as those of the full size specimens. The measurement of lateral expansion, or ductility, was more useful in estimating the impact property of JFMS than that of fracture appearance (fibrous fracture). (author)

2

Thermal analysis on Charpy V-notch test specimens  

International Nuclear Information System (INIS)

The results obtained from finite element thermal transient analyses performed in Charpy V-notch test specimens are presented in order to verify the validity of two recommendations included in ASTM A370 and E23 standards: the minimum immersion time of the specimen in a liquid bath to reach a isothermal state at test temperature; and the maximum time interval between the removal of the specimen from the bath and the execution of the test. (author). 7 refs, 16 figs, 3 tabs

3

Ductile crack initiation in the Charpy V-notch test  

International Nuclear Information System (INIS)

Initiation and growth of a crack in the Charpy V-notch test was investigated by performing both static and impact controlled deflection tests. Test specimens were deformed to various deflections, heat-tinted to mark crack extension and broken apart at low temperature to allow extension measurements. Measurement of the crack extension provided an estimate of crack initiation as defined by different criteria. Crack initiation starts well before maximum load, and is dependent on the definition of ''initiation''. Using a definition of first micro-initiation away from the ductile blunting, computer model predictions agreed favorably with the experimental results

4

Results of charpy V-notch impact testing of structural steel specimens irradiated at ?30 degrees C to 1 x 1016 neutrons/cm2 in a commercial reactor cavity  

International Nuclear Information System (INIS)

A capsule containing Charpy V-notch (CVN) and mini-tensile specimens was irradiated at ? 30 degrees C (? 85 degrees F) in the cavity of a commercial nuclear power plant to a fluence of 1 x 1016 neutrons/cm2 (> 1MeV). The capsule included six CVN impact specimens of archival High Flux Isotope Reactor A212 grade B ferritic steel and five CVN impact specimens of a well-studied A36 structural steel. This irradiation was part of the ongoing study of neutron-induced damage effects at the low temperature and flux experienced by reactor supports. The plant operators shut down the plant before the planned exposure was reached. The exposure of these specimens produced no significant irradiation-induced embrittlement. Of interest were the data on unirradiated specimens in the L-T orientation machined from a single plate of A36 structural steel, which is the same specification for the structural steel used in some reactor supports. The average CVN energy of five unirradiated specimens obtained from one region of the plate and tested at room temperature was ? 99 J, while the energy of 11 unirradiated specimens from other locations of the same plate was 45 J, a difference of ? 220%. The CVN impact energies for all 18 specimens ranged from a low of 32 J to a high of 111 J. Moreover, it appears that the University of Kansas CVN impact energy data of the unirradiated specimens at the 100-J level are shifted toward higher temperatures by about 20 K. The results were an example of the extent of scatter possible in CVN impact testing. Generic values for the CVN impact energy of A36 should be used with caution in critical applications

5

Local strain energy density near sharp V-notches in plates  

Science.gov (United States)

Conditions of fracture of the local strain energy density, which were first formulated by Sih for a sharp V-notch with an arbitrary tip angle, are proposed. The edges of the considered V-notch are free from loading. If loading schemes of type I and type II are used, it is shown that the known brittle fracture conditions proposed by Sih contradict one of the basic postulates in fracture mechanics: the greater the intensity of stresses or elastic energy near the V-notch tip, the greater the probability of crack propagation. The proposed new conditions of fracture (in a polar coordinate system) are obtained as a result of independent determination of the energy densities of changes in volume and shape. In this case, the above-mentioned contradiction is eliminated.

Ovcharenko, Yu. N.

2013-11-01

6

Three-dimensional vibrations of cylindrical elastic solids with V-notches and sharp radial cracks  

Science.gov (United States)

This paper provides free vibration data for cylindrical elastic solids, specifically thick circular plates and cylinders with V-notches and sharp radial cracks, for which no extensive previously published database is known to exist. Bending moment and shear force singularities are known to exist at the sharp reentrant corner of a thick V-notched plate under transverse vibratory motion, and three-dimensional (3-D) normal and transverse shear stresses are known to exist at the sharp reentrant terminus edge of a V-notched cylindrical elastic solid under 3-D free vibration. A theoretical analysis is done in this work utilizing a variational Ritz procedure including these essential singularity effects. The procedure incorporates a complete set of admissible algebraic-trigonometric polynomials in conjunction with an admissible set of " edge functions" that explicitly model the 3-D stress singularities which exist along a reentrant terminus edge (i.e., ?>180°) of the V-notch. The first set of polynomials guarantees convergence to exact frequencies, as sufficient terms are retained. The second set of edge functions—in addition to representing the corner stress singularities—substantially accelerates the convergence of frequency solutions. This is demonstrated through extensive convergence studies that have been carried out by the investigators. Numerical analysis has been carried out and the results have been given for cylindrical elastic solids with various V-notch angles and depths. The relative depth of the V-notch is defined as (1- c/ a), and the notch angle is defined as (360°- ?). For a very small notch angle (1° or less), the notch may be regarded as a "sharp radial crack." Accurate (four significant figure) frequencies are presented for a wide spectrum of notch angles (360°- ?), depths (1- c/ a), and thickness ratios ( a/ h for plates and h/ a for cylinders). An extended database of frequencies for completely free thick sectorial, semi-circular, and segmented plates and cylinders are also reported herein as interesting special cases. A generalization of the elasticity-based Ritz analysis and findings applicable here is an arbitrarily shaped V-notched cylindrical solid, being a surface traced out by a family of generatrix, which pass through the circumference of an arbitrarily shaped V-notched directrix curve, r( ?), several of which are described for future investigations and close extensions of this work.

McGee, O. G.; Kim, J. W.

2010-02-01

7

Ductile crack initiation in the Charpy V-notch test  

International Nuclear Information System (INIS)

Crack initiation and growth in the Charpy V-notch test are investigated for controlled deflections of the specimen applied both by slow bending and by impact. Charpy test specimens were deformed to various deflections, heat-tinted to mark the crack extensions, and broken apart at low temperature to allow measurement of the crack extensions. These measurements provide estimates of crack initiation as defined by various criteria. The loading point at which crack initiation occurs depends on the particular definition being used for ''initiation,'' but in all cases it is well before the maximum load is reached. When initiation is defined as the first observable micro-initiation away from the ductile blunting of the notch root, the experimental results are in good agreement with computer modeling predictions

8

The fracture toughness evaluation by instrumented charpy V-notch test for irradiated narrow-gap mig weldment  

International Nuclear Information System (INIS)

This paper is a proposal to make some empirical correlation between the fracture toughness and the charpy V-notch impact test results for the irradiated Narrow Gap MIG weld deposit metal and their irradiated embrittlement is also examined by the method presently used in practice, determining the transition temperature shift at 30ft-lb absorbed energy. This study predicts a good correlation between the actual measurement of fracture toughness and the fracture toughness derived from the charpy V-notch impact test results. (orig./HP)

9

Charpy V-notch impact testing and brittle fracture in an A508 CL.3 bainitic steel  

Energy Technology Data Exchange (ETDEWEB)

Charpy V-notch impact testing is widely used in the toughness diagnostic of large forged components, e.g. the vessel of pressurized water reactors (PWR). In an A508 Cl.3 bainitic steel tested at low temperature, cleavage occurs at the initiation of unstable failure. The results reported here are part of both an experimental program and numerical investigations in order to establish a non-empirical relationship between Charpy V-notch energy CVN and fracture toughness K{sub IC}. The Beremin model which is based on a critical fracture stress concept and Weibull statistics, is only applied on CVN tests. (orig.). 10 refs.

Tahar, M.; Brillaud, C.; Forget, P.; Piques, R. [Ecole des Mines de Paris, Evry (France). Centre des Materiaux

1997-08-01

10

Charpy V-notch impact testing and brittle fracture in an A508 CL.3 bainitic steel  

International Nuclear Information System (INIS)

Charpy V-notch impact testing is widely used in the toughness diagnostic of large forged components, e.g. the vessel of pressurized water reactors (PWR). In an A508 Cl.3 bainitic steel tested at low temperature, cleavage occurs at the initiation of unstable failure. The results reported here are part of both an experimental program and numerical investigations in order to establish a non-empirical relationship between Charpy V-notch energy CVN and fracture toughness KIC. The Beremin model which is based on a critical fracture stress concept and Weibull statistics, is only applied on CVN tests. (orig.)

11

Charpy V-Notch Impact Testing and Brittle Fracture in an A508 CL.3 Bainitic Steel  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Charpy V-notch impact testing is widely used in the toughness diagnostic of large forged components, e.g. the vessel of pressurized water reactors (PWR). In an A508 Cl.3 bainitic steel tested at low temperature, cleavage occurs at the initiation of unstable failure. The results reported here are part of both an experimental program and numerical investigations in order to establish a non-empirical relationship between Charpy V-notch energy CVN and fracture toughness KIC. The Beremin model whi...

Tahar, M.; Brillaud, C.; Forget, P.; Piques, R.

1997-01-01

12

Computer simulation of the Charpy V-notch toughness test  

International Nuclear Information System (INIS)

The dynamic Charpy V-notch test was simulated on a computer. The calculational models (for A-533 Grade B class 1 steel) used both a rounded and a flat-tipped striker. The notch stress/strain state was found to be independent of the three-point loading type and was most strongly correlated with notch-opening displacement. The dynamic stress/strain state at the time of fracture initiation was obtained by comparing the calculated deformed shape with that obtained in interrupted Charpy V-notch tests where cracking had started. The calculation was also compared with stress/strain states calculated in other geometries at failure. The distribution and partition of specimen energy was calculated and adiabatic heating and strain rate are discussed

13

Computer simulation of the Charpy V-notch toughness test  

International Nuclear Information System (INIS)

The impact of a striker with the ASTM Type A Charpy V-Notch specimen has been calculated. An elastic-plastic constitutive law with J2-flow theory and isotropic hardening was used to model A-533 Grade B class 1 steel at 1000C. Large strain and rotation are accounted for. It was found that the notch stress-strain state was independent of the three-point loading type (round- or flat-tip striker or pressure push) and was most strongly correlated with notch-opening displacement. The dynamic stress-strain state at the time of fracture initiation was obtained by comparing the calculated deformed shape with that obtained in interrupted Charpy-V-notch tests where cracking had started. This time agreed with a computed prediction of fracture initiation obtained using a computer model of material damage. Cracking starts at the notch at about 40% of the maximum load found in an instrumented Charpy test. The distribution and partition of specimen energy has also been calculated. Adiabatic heating and strain rate are discussed. (author)

14

The Evolution of the Maine Lobster V-Notch Practice: Cooperation in a Prisoner's Dilemma Game  

Directory of Open Access Journals (Sweden)

Full Text Available The Maine lobster industry is experiencing record high catches because, in all probability, of an effective management program. One of the most important conservation measures is the V-notch program that allows fishermen to conserve proven breeding females by notching the tails of egg-bearing lobsters. Such marked lobsters may never be taken. Although thousands of lobster fishermen participate, it is a voluntary practice. The genesis of this practice is not easily explained, because V-notching poses a prisoner's dilemma problem that gives fishermen an incentive to avoid the practice. The most common explanations for ways to overcome prisoner's dilemma problems will not work in the case of the V-notch. An unusual combination of factors explains the V-notch program: (1 a strong belief among those in the industry that the V-notch is effective in conserving the lobster stock; (2 a low discount rate because the long-term gains from V-notching are higher than the one-time gain from defection; (3 a gain in reputation for those who V-notch. At the start of the 20th century, fishermen did not V-notch; by the end of the century, V-notching was common. We explain the change in strategies using a three-parameter evolutionary model that emphasizes the importance of culture change.

Roy Gardner

2011-03-01

15

Computer model for ductile fracture: applications to the Charpy V-notch test. Phase one report  

International Nuclear Information System (INIS)

A computer model for predicting ductile-fracture initiation and propagation in nuclear reactor pressure vessel steel is described. The model predicts fracture toughness from Charpy and tension tests using standard surveillance specimens. The fracture model is based on plastic strain. Fracture starts or a crack extends when the integrated product of the equivalent plastic-strain increment and a function of the mean stress exceeds a critical value over a critical length. This critical length is characteristic of the microstructure of the material. The computer fracture model is calibrated by computer simulation of simple and notched round-bar tension tests and a precracked compact tension test of A533 Grade B Class 1 steel and two different heat treatments of this steel. The model is then used to predict fracture initiation and flat propagation in the standard Charpy V-notch specimen. The computed results are compared with experiments. A correlation is presented between the energy in the Charpy V-notch specimen at fracture initiation on the upper shelf and fracture toughness as measured by J/sub Ic/

16

Vibrations Of Circular Plates Having V-notches Or Sharp Radial Cracks  

Science.gov (United States)

This paper provides the first known free vibration data for circular plates having V-notches. A V-notch has bending moment singularities at its sharp corner due to the transverse vibratory motion. A theoretical analysis is undertaken using two sets of admissible displacement functions, (1) algebraic-trigonometric polynomials and (2) corner functions. These function sets are used with the Ritz method. The first set guarantees convergence to the exact frequencies as sufficient terms are taken. The second set represents the corner singularities exactly, and accelerates convergence greatly. Numerical results are given for non-dimensional frequencies of completely free circular plates having various notch angles and depths. As the notch angle becomes very small, a sharp radial crack ensues. Convergence studies demonstrate the necessity of adding corner functions to achieve accurate frequencies. Extensive, accurate (five significant figure) frequencies are presented for the spectrum of notch angles (0°, 1°, 5°, 10°, 30°, 60° and 90°) and depths. The effect of the Poisson ratio on the frequencies in the case of shallow notches is also investigated. Sharp notches are found to reduce each of the first six frequencies from those of a complete circular plate, whereas large notch angles can increase some of the frequencies. Nodal patterns are shown for plates having 5° notches. The first known frequencies for completely free sectorial, semi-circular and segmented plates are also given as special cases.

Leissa, A. W.; McGee, O. G.; Huang, C. S.

1993-02-01

17

Use of forces from instrumented Charpy V-notch testing to determine crack-arrest toughness  

Energy Technology Data Exchange (ETDEWEB)

The objective of this investigation is an estimation of the crack-arrest toughness, particularly of irradiated materials, from voltage versus time output of an instrumented setup during a test on a Charpy V-notch (CVN) specimen. This voltage versus time trace (which can be converted to force versus displacement) displays events during fracture of the specimen. Various stages of the fracture process can be identified on the trace, including an arrest point indicating arrest of brittle fracture. The force at arrest, F{sub a}, versus test temperature, T, relationship is examined to explore possible relationships to other experimental measures of crack-arrest toughness such as the drop-weight nil-ductility temperature (NDT), or crack-arrest toughness, K{sub a}. For a wide range of weld and plate materials, the temperature at which F{sub a} = 2.45 kN correlates with NDT with a standard deviation, sigma, of about 11 K. Excluding the so-called low upper-shelf energy (USE) welds from the analysis resulted in F{sub a} = 4.12 kN and {sigma} = 6.6 K. The estimates of the correlation of the temperature for F{sub a} = 7.4 kN with the temperature at 100-MPa{radical}m level for a mean American Society of Mechanical Engineers (ASME) type K{sub Ia} curve through crack-arrest toughness values show that prediction of conservative values of K{sub a} are possible.

Iskander, S.K.; Nanstad, R.K.; Sokolov, M.A.; McCabe, D.E.; Hutton, J.T.

1996-06-01

18

Influence of phase transformations on the asymptotic residual stress distribution arising near a sharp V-notch tip  

International Nuclear Information System (INIS)

In this work, the residual stress distribution induced by the solidification and cooling of a fusion zone in the vicinity of a sharp V-notch tip is investigated. The intensity of the residual asymptotic stress fields, quantified by the notch stress intensity factors, was studied for two different V-notch specimen geometries under generalized plane-strain conditions. In order to analyze the influence of phase transformations on the obtained results, simulations with and without the effects of phase transformation were carried out on ASTM SA 516 steel plates. Thanks to the possibilities of numerical modelling, additional analyses were performed without taking into account the transformation plasticity phenomenon. It was found that phase transformation effects (both volume change and transformation plasticity) have a great influence on the intensity and sign of the asymptotic stress fields at the sharp V-notch tips. This result is believed to be very important for the correct numerical determination (and future applications) of notch stress intensity factors resulting from asymptotic residual stress distributions induced by transient thermal loads. The analyses were performed with the finite element code SYSWELD. (paper)

19

Vibrations of circular plates with clamped v-notches or rigidly constrained radial cracks  

Science.gov (United States)

This study offers the first known free vibration data for thin circular plates with clamped V-notches. The classical Ritz method is employed with two sets of admissible functions assumed for the transverse vibratory displacements. These sets include: (1) mathematically complete algebraic-trigonometric polynomials which guarantee convergence to exact frequencies as sufficient terms are retained; and (2) corner functions which account for the bending moment singularities at the sharp corner of the V-notch. Extensive convergence studies summarized herein confirm that the corner functions substantially enhance the convergence and accuracy of non-dimensional frequencies for circular plates with clamped notches. Numerical results are obtained for plates having their circular edges completely free. Accurate (five significant figure) frequencies are presented for a wide spectrum of notch angles (0°, 5°, 10°, 30°, 60° and 90°) and depths. For very small notch angles, a rigidly constrained radial crack ensues. Some general findings are that, for the spectrum of notch angles examined, the first six frequencies increase as the notch depth increases, more so in the higher modes than the lower ones. The frequency increase with increasing notch depth is quite substantial for the semi-circular plates, and for segmented plates with sector angles less than 180°. For a constant notch depth, it is found that there is a substantial reduction in the first six frequencies as notch angle decreases. Normalized contours of the transverse vibratory displacement are shown for plates having 90° and 5° notches of various depths ranging from deep to very shallow. The first known frequencies and mode shapes for sectorial, semi-circular and segmented plates with clamped radial edges are also presented as special cases of the title problem.

Mcgee, O. G.; Leissa, A. W.; Huang, C. S.; Kim, J. W.

1995-03-01

20

Critical applied stresses for a crack initiation from a sharp V-notch  

Directory of Open Access Journals (Sweden)

Full Text Available The aim of the paper is to estimate a value of the critical applied stress for a crack initiation from a sharp V-notch tip. The classical approach of the linear elastic fracture mechanics (LELM was generalized, because the stress singularity exponent differs from 0.5 in the studied case. The value of the stress singularity exponent depends on the V-notch opening angle. The finite element method was used for a determination of stress distribution in the vicinity of the sharp V-notch tip and for the estimation of the generalized stress intensity factor depending on the V-notch opening angle. Critical value of the generalized stress intensity factor was obtained using stability criteria based on the opening stress component averaged over a critical distance d from the V-notch tip and generalized strain energy density factor. Calculated values of the critical applied stresses were compared with experimental data from the literature and applicability of the LEFM concept is discussed.

L. Náhlík,

2014-10-01

 
 
 
 
21

Stress and strain analysis in the standard V-notched bars  

International Nuclear Information System (INIS)

The stress and strain distribution during plane strain bending of the standard V-notched specimen using the visioplasticity method are presented. The solution obtained is based on actual observation of grid distorsion during the bending process. The method can be applied to work-hardening as well as non work-hardening materials. Theoretical results using the slipline theory and the finite element methods were also compared to those obtained from the visioplasticity method. The slipline theory yields a maximum tensile stress at the edge of the plastic zone. Recently, it was shown that the maximum tensile stress is attained inside the plastic zone surrounding the notch and not at its edge. The strain distribution along the notch center line using the visioplasticity method was found to be similar to that obtained from microhardness measurements and finite element analysis. The maximum stress was found to occur at the notch root for bend angles above general yield. The longitudinal atress distribution for small angles of bend was found to be similar to that obtained using the finite element method

22

Material inertia and size effects in the Charpy V-notch test  

DEFF Research Database (Denmark)

The effect of material inertia on the size dependence of the absorbed energy in the Charpy V-notch test is investigated. The material response is characterized by an elastic-viscoplastic constitutive relation for a porous plastic solid, with adiabatic heating due to plastic dissipation and the resulting thermal softening accounted for. The onset of cleavage is taken to occur when a critical value of the maximum principal stress is attained over a critical volume. Plane strain dynamic analyses are carried out for geometrically similar specimens of various sizes with all parameters adjusted so that a quasi-static analysis would predict a size independent response. Sizes ranging from 1/4 to 16 times the ASTM standard size are analyzed and two sets of material properties are considered. No size effect is seen below a critical specimen size. Above this limit, a monotonic increase with specimen size is found for the normalized lower shelf energy (LSE) and the normalized upper shelf energy (USE) for both sets of material properties. The ductile-to-brittle transition temperature (DBTT) is found to increase monotonically with specimen size for one set of material properties, but a non-monotonic variation is found for the other set of material properties. (C) 2004 Elsevier SAS. All rights reserved.

Tvergaard, Viggo

2004-01-01

23

CALIBRATION OF A 90 DEGREE V-NOTCH WEIR USING PARAMETERS OTHER THAN UPSTREAM HEAD  

Science.gov (United States)

Traditional calibration of 90 degrees V-Notch Weirs has involved the establishment of a head-discharge relationship where the head is measured upstream of weir drawdown effects. This parameter is often difficult to mesure in field weir installations. Two other parameters are prop...

24

Influence of Hydrogen on the Mechanical Properties of Charpy V - Notch Specimens of Low Carbon Steel.  

Science.gov (United States)

Hydrogen embrittlement has been studied in steels containing 0.16% and 0.006% carbon which were subjected to an electrolytical charging. Charpy V - notch specimens of these materials were tested in three point slow bend loading. No embrittling effect of h...

A. P. Fayet

1966-01-01

25

The evaluation of tempered martensite embrittlement in 4130 steel by instrumented charpy V-notch testing  

Science.gov (United States)

Tempered martensite embrittlement (TME) was studied in vacuum-melted 4130 steel with either 0.002 or 0.02 wt pct P. TME was observed as a severe decrease in Charpy V-notch impact energy, from 46 ft-lb. at 200 °C to 35 ft-lb. at 300 °C in the low P alloy. The impact energy of the high P alloy was consistently lower than that of the low P alloy in all tempered conditions. Fracture was transgranular for all specimens; therefore, segregation of P to the prior austenitic grain boundaries was not a factor in the o°Currence of TME. Analysis of load-time curves obtained by instrumented Charpy testing revealed that the embrittlement is associated with a drop in the pre-maximum-load and post-unstable-fracture energies. In specimens tempered at 400 °C the deleterious effect of phosphorus on impact energy became pronounced, a result more consistent with classical temper embrittlement rather than TME. A constant decrease in pre-maximum-load energy due to phosphorus content was observed. The pre-maximum-load energy decreases with increasing tempering temperature in the range of 200 °C to 400 °C, a result explained by the change in work hardening rate. Carbon extraction replicas of polished and etched as-quenched specimens revealed the presence of Fe2MoC and/or Fe3C carbides retained after austenitizing. Ductile crack extension close to the notch root was related to the formation of fine micro voids at the retained carbides.

Zia-Ebrahimi, F.; Krauss, G.

1983-06-01

26

Evaluation of fracture toughness in dental ceramics using indentation and SEVNB (Single Edge V-Notched Beam)-method  

International Nuclear Information System (INIS)

In this work, the fracture toughness of different ceramics based on Al2O3 and ZrO2 were evaluated using, comparatively two methods, Vickers indentation and SEVNB (Single Edge V-Notched Beam) method. Al2O3, ZrO2(3%Y2O3) micro-particled and ZrO2(3%Y2O3) nanometric, ZrO2-Al2O3 and Al2O3-ZrO2 composites were sintered at different temperatures. Samples were characterized by relative density, X-ray diffraction, SEM, and mechanical evaluation by hardness, bending strength and fracture toughness obtained by ickers indentation and SEVNB-method. The results were presented comparing the densification and microstructural results. Furthermore, the advantages and limitations of each method were discussed. (author)

27

Study on irradiation embrittlement of ferritic steels by means of impact testing with miniaturized Charpy V-notch specimens  

International Nuclear Information System (INIS)

A brief description is given of a specially designed equipment that permits the instrumented Charpy impact test with miniaturized V-notch specimens of a cross section as small as 1.5 by 1.5 or 1.0 by 1.0 mm. The effectiveness of using the miniaturized specimens in estimating the ductile-to-brittle transition temperature (DBTT) and the upper shelf energy (USE) for full size specimens of a ferritic steel is examined. It is shown that the data obtained from the miniaturized specimens can be used to estimate the DBTT and USE for full size specimens. The result is applied to the evaluation of the DBTT and USE of several kinds of ferritic steels that were neutron-irradiated in the JMTR (Japan Materials Testing Reactor). 14 refs.; 11 figs.; 4 tabs

28

Fracture toughness by broken Charpy V-notch specimens  

International Nuclear Information System (INIS)

The main objective of SCK-CEN's research on fracture toughness is to to evaluate the fracture toughness of the reactor pressure vessel material as part of a structural integrity programme. To this end, SCK-CEN has designed the Miniature Compact Tension (MC(T) geometry that uses four times less material compared to Charpy specimens. The MC(T) specimens were qualified and the results were compared with reconstituted Pre cracked Charpy. The comparative results are in good agreement and are discussed in the paper

29

Dynamic analysis of the Charpy V-notch test  

International Nuclear Information System (INIS)

A computer simulation of a standard Charpy test from impact to the start of ductile tearing is reported. Both striker and specimens are modelled. The specimen is made of SA533 Grade B Class 1 nuclear-pressure-vessel steel and tested at 100 C. The results describe the wave interaction causing momentary separation of striker and specimen. The notch tip stress and strain at time of crack initiation are described, both for a plane-strain model and for the 1 cm thickness. The implications for correlation of total Charpy energy and initiation energy with fracture toughness are discussed

30

Experiment HFIR-MFE-T3 for low-temperature irradiation of miniaturized Charpy V-notch specimens of nickel-doped ferritic steels  

International Nuclear Information System (INIS)

The HFIR-MFE-T3 experimental capsule is described. This experiment consists of miniature Charpy V-notch specimens of 12 Cr-1 MoVW and 12 Cr-1 MoVW-2 Ni alloys. The different levels of nickel will result in different helium levels generated during irradiation, and thus will allow for an evaluation of the effect of helium on impact properties. Irradiation of the capsule has started with projected fluence at midplane that will produce 10 dpa expected by January 1982

31

Evaluation of fracture toughness in dental ceramics using indentation and SEVNB (Single Edge V-Notched Beam)-method; Avaliacao da tenacidade a fratura de ceramicas dentarias atraves do metodo de entalhe - SEVNB (Single Edge V-Notched Beam)  

Energy Technology Data Exchange (ETDEWEB)

In this work, the fracture toughness of different ceramics based on Al{sub 2}O{sub 3} and ZrO{sub 2} were evaluated using, comparatively two methods, Vickers indentation and SEVNB (Single Edge V-Notched Beam) method. Al{sub 2}O{sub 3}, ZrO{sub 2}(3%Y{sub 2}O{sub 3}) micro-particled and ZrO{sub 2}(3%Y{sub 2}O{sub 3}) nanometric, ZrO{sub 2}-Al{sub 2}O{sub 3} and Al{sub 2}O{sub 3}-ZrO{sub 2} composites were sintered at different temperatures. Samples were characterized by relative density, X-ray diffraction, SEM, and mechanical evaluation by hardness, bending strength and fracture toughness obtained by ickers indentation and SEVNB-method. The results were presented comparing the densification and microstructural results. Furthermore, the advantages and limitations of each method were discussed. (author)

Santos, L.A.; Santos, C.; Souza, R.C.; Ribeiro, S. [Universidade de Sao Paulo (DEMAR/EEL/USP), Lorena, SP (Brazil). Escola de Engenharia de Lorena. Dept. de Engenharia de Materiais. Polo Urbo-Industrial; Strecker, K. [Universidade Federal de Sao Joao del-Rei (DME/UFSJ), MG (Brazil). Dept. de Materiais Eletricos; Oberacker, R. [Karlsruhe Univ. (Germany)

2009-07-01

32

Analysis of Charpy V-notch impact toughness of irradiated A533-B class 1 plate and four submerged-arc welds  

International Nuclear Information System (INIS)

Studies of the effects of neutron irradiation on Charpy V-notch impact properties of steels have, in general, included a minimum number of tests for each combination of material and irradiation parameters. The present study attempts to apply statistical analyses with multiple testing at selected temperatures to assess the accuracy and reliability of results. Charpy V-notch impact test specimens were irradiated in the Bulk Shielding Reactor at Oak Ridge National Laboratory at 2880C to target neutron fluences of 2 X 1023 neutrons (n)/m2 (>1 MeV). The materials were ASTM A533-B Class 1 plate (HeavySection Steel Technology Plate 02) and four submerged-arc welds representing current nuclear pressure vessel fabrication practice. Both unirradiated and irradiated specimens were tested by two separate groups and multiple tests were conducted at several selected temperatures. Statistical analyses permitted determination of material and test variability and an interlaboratory comparison. Several Charpy curve-fitting methods were used and results are compared with predictions from several ''trend curve'' expressions

33

First approach for the determination of J-integral R-curves on charpy V-notch specimens  

International Nuclear Information System (INIS)

As part of the pressure vessel surveillance programmes of Swiss nuclear power stations, prefatigued, charpy V-notch specimens are currently under irradiation exposure. However, as there is still no consensus as to the correct evaluation procedure for such tests, the conclusions which can be drawn from the results are somewhat limited. This work deals with the alternative possibility of performing the experiments in the same manner as for large, three-point bend-type specimens. The procedure is based upon the proposal of J.R. Rice, which claims that the J-integral is a characteristic value of the material and independent of specimen geometry. If this is the case, then it can be concluded that the specimen size does not play a role in the physical initiation of the propagation of an existing flaw. Exceptions to this rule are only expected in the case of a moving crack. It is shown that the results of the application of this procedure are promising. (author) 4 figs., 14 refs

34

Subsized bend and Charpy V-notch specimens for irradiated testing  

International Nuclear Information System (INIS)

Characterization of the fracture resistance of structural materials from specimens small in volume is an essential element of fission and fusion reactor design and alloy development. In this study 1/3-sized Charpy V-notch specimens and small bend bars ranging in thickness down to 2.5 mm have been investigated. Techniques have been developed for fabricating these specimens and testing them over a temperature range of 170 to 590 K under static and dynamic conditions. Tests have been performed to extract fracture mechanics parameters (K/sub Ic/,J/sub Ic/) and fundamental material parameters (e.g., microcleavage fracture stress ?/sub f//sup */) and to examine behavior anticipated in thin wall ferritic structures at temperatures corresponding to the lower shelf

35

Relationships between Charpy V-notch impact energy and fracture toughness  

International Nuclear Information System (INIS)

This report documents the investigation of correlations between Charpy V-notch impact energy and fracture toughness. Three distinct types of correlations were examined: (1) the Rolfe-Novak-Barsom upper-shelf correlation, (2) the hyperbolic tangent (tanh) correlation, and (3) the J-?a correlation. The Rolfe-Novak-Barsom correlation is a straight line relationship between functions of the Charpy energy and the static initiation toughness, while the tanh correlation relates functions of the Charpy energy and either the static or the dynamic toughness through the use of statistically determined curve fits based on the tanh curve. The J-?a correlation represents power law estimates of resistance curves in the upper-shelf temperature range

36

Effects of Notch Misalignment and Tip Radius on Displacement Field in V-Notch Rail Shear Test as Determined by Photogrammetry  

Science.gov (United States)

Evolution of the 3D strain field during ASTM-D-7078 v-notch rail shear tests on 8-ply quasi-isotropic carbon fiber/epoxy laminates was determined by optical photogrammetry using an ARAMIS system. Specimens having non-optimal geometry and minor discrepancies in dimensional tolerances were shown to display non-symmetry and/or stress concentration in the vicinity of the notch relative to a specimen meeting the requirements of the standard, but resulting shear strength and modulus values remained within acceptable bounds of standard deviation. Based on these results, and reported difficulty machining specimens to the required tolerances using available methods, it is suggested that a parametric study combining analytical methods and experiment may provide rationale to increase the tolerances on some specimen dimensions, reducing machining costs, increasing the proportion of acceptable results, and enabling a wider adoption of the test method.

Hill, Charles S.; Oliveras, Ovidio M.

2011-01-01

37

Analysis method of Charpy V-notch impact data before and after electron beam welding reconstitution  

International Nuclear Information System (INIS)

Research highlights: ? The EBW can be successful applied for reconstitution of the CVN specimens. ? The equality of DBTT was checked by t/t'-test with its uncertainty. ? The CVN data before and after reconstitution is in good agreement. - Abstract: The specimen reconstitution technique is one of the most promising techniques to improve the surveillance program of the reactor pressure vessel (RPV). In this study, unirradiated 30Mn2V low-alloy steels were chosen as the test materials, and the broken halves of Charpy V-notch impact (CVN) specimens were reconstituted to be new CVN specimens by the electron beam welding (EBW) as a pilot study in China. Taking the 20 insert reconstituted specimens as an example, Boltzmann function was used to fit the CVN data, the ductile-brittle transition temperature (DBTT) and its uncertainty were evaluated, and the equality of DBTT between the reconstituted specimens and original specimens was checked by t/t'-test. There is a great consistency between CVN data of EBW reconstituted specimens and that of original specimens.

38

Analysis method of Charpy V-notch impact data before and after electron beam welding reconstitution  

Energy Technology Data Exchange (ETDEWEB)

Research highlights: The EBW can be successful applied for reconstitution of the CVN specimens. The equality of DBTT was checked by t/t'-test with its uncertainty. The CVN data before and after reconstitution is in good agreement. - Abstract: The specimen reconstitution technique is one of the most promising techniques to improve the surveillance program of the reactor pressure vessel (RPV). In this study, unirradiated 30Mn2V low-alloy steels were chosen as the test materials, and the broken halves of Charpy V-notch impact (CVN) specimens were reconstituted to be new CVN specimens by the electron beam welding (EBW) as a pilot study in China. Taking the 20 insert reconstituted specimens as an example, Boltzmann function was used to fit the CVN data, the ductile-brittle transition temperature (DBTT) and its uncertainty were evaluated, and the equality of DBTT between the reconstituted specimens and original specimens was checked by t/t'-test. There is a great consistency between CVN data of EBW reconstituted specimens and that of original specimens.

Wan Qiangmao, E-mail: wanqm@hotmail.co [Department of Material Engineering, School of Power and Mechanical Engineering, Wuhan University, Luojia Hill, Wuhan City (China); Research Center of Plant Life Management, Suzhou Nuclear Power Research Institute, Xihuan Road 1788, Suzhou City (China); Wang Rong-shan, E-mail: snpi@qq.co [Research Center of Plant Life Management, Suzhou Nuclear Power Research Institute, Xihuan Road 1788, Suzhou City (China); Shu Guogang [Department of Material Engineering, School of Power and Mechanical Engineering, Wuhan University, Luojia Hill, Wuhan City (China); China Nuclear Power Enginerring Co. Ltd., Shangbu Mid-Way 1001, Shenzhen City (China); Ding Hui [Department of Material Engineering, School of Power and Mechanical Engineering, Wuhan University, Luojia Hill, Wuhan City (China); Huang Ping; Lv Feng; Weng Likui [Research Center of Plant Life Management, Suzhou Nuclear Power Research Institute, Xihuan Road 1788, Suzhou City (China)

2011-02-15

39

The assets and limitations of the Charpy V-notch approach to pressure vessel safety in the surveillance programmes - A proposal for modifications  

International Nuclear Information System (INIS)

The Charpy V-notch impact test data forms the primary basis in the present surveillance programmes of analysing the effects of radiation on the reactor pressure vessel. The weaknesses of this approach are discussed with regard to the requirement of minimum initial upper-shelf energy. The enforcement of this requirement could lead to regulatory action with a risk for outage of some of the existing commercial reactors. To prevent such consequences resulting from the ill-defined property of upper-shelf energy, a proposal is made for the introduction of fracture mechanics specimens in to the surveillance programmes in addition to the Charpy V specimens. Using the elastic-plastic fracture mechanics approach the material degradation due to such effects as strain ageing and radiation could then be evaluated in a much more quantitative manner. (author)

40

On impact testing of subsize Charpy V-notch type specimens  

International Nuclear Information System (INIS)

The potential for using subsize specimens to determine the actual properties of reactor pressure vessel steels is receiving increasing attention for improved vessel condition monitoring that could be beneficial for light-water reactor plant-life extension. This potential is made conditional upon, on the one hand, by the possibility of cutting samples of small volume from the internal surface of the pressure vessel for determination of actual properties of the operating pressure vessel. The plant-life extension will require supplemental surveillance data that cannot be provided by the existing surveillance programs. Testing of subsize specimens manufactured from broken halves of previously tested surveillance Charpy V-notch (CVN) specimens offers an attractive means of extending existing surveillance programs. Using subsize CVN type specimens requires the establishment of a specimen geometry that is adequate to obtain a ductile-to-brittle transition curve similar to that obtained from full-size specimens. This requires the development of a correlation of transition temperature and upper-shelf toughness between subsize and full-size specimens. The present study was conducted under the Heavy-Section Steel Irradiation Program. Different published approaches to the use of subsize specimens were analyzed and five different geometries of subsize specimens were selected for testing and evaluation. The specimens were made from several types of pressure vessel steels with a wide range of yield strengths, transition temperatures, and upper-shelf energies (USEs). Effects of specimen dimensions, including depth, angle, and radius of notch have been studied. The correlation of transition temperature determined from different types of subsize specimens and the full-size specimen is presented. A new procedure for transforming data from subsize specimens was developed and is presented

 
 
 
 
41

On impact testing of subsize Charpy V-notch type specimens  

Energy Technology Data Exchange (ETDEWEB)

The potential for using subsize specimens to determine the actual properties of reactor pressure vessel steels is receiving increasing attention for improved vessel condition monitoring that could be beneficial for light-water reactor plant-life extension. This potential is made conditional upon, on the one hand, by the possibility of cutting samples of small volume from the internal surface of the pressure vessel for determination of actual properties of the operating pressure vessel. The plant-life extension will require supplemental surveillance data that cannot be provided by the existing surveillance programs. Testing of subsize specimens manufactured from broken halves of previously tested surveillance Charpy V-notch (CVN) specimens offers an attractive means of extending existing surveillance programs. Using subsize CVN type specimens requires the establishment of a specimen geometry that is adequate to obtain a ductile-to-brittle transition curve similar to that obtained from full-size specimens. This requires the development of a correlation of transition temperature and upper-shelf toughness between subsize and full-size specimens. The present study was conducted under the Heavy-Section Steel Irradiation Program. Different published approaches to the use of subsize specimens were analyzed and five different geometries of subsize specimens were selected for testing and evaluation. The specimens were made from several types of pressure vessel steels with a wide range of yield strengths, transition temperatures, and upper-shelf energies (USEs). Effects of specimen dimensions, including depth, angle, and radius of notch have been studied. The correlation of transition temperature determined from different types of subsize specimens and the full-size specimen is presented. A new procedure for transforming data from subsize specimens was developed and is presented.

Mikhail, A.S.; Nanstad, R.K.

1994-12-31

42

The use of slow-bend pre-cracked Charpy V-notch specimens to characterize half-bead repair welds  

International Nuclear Information System (INIS)

Following the use of the half-bead repair welding procedure, as the pre-cracked Charpy V-notch specimen permits an assessment of the various regions of the repair weldment with a minimal use of materials, Charpy V-notch specimen blanks were removed from the repair weldment in such a manner that the fracture toughness of the heat-affected-zone (HAZ) between the base material and repair weld could be determined. Then, pre-cracked Charpy V-notch specimens were used to characterize the various zones of a repair weldment in an intermediate test vessel for which a pressurization test was specifically designed to assess the effect of repair welding on its integrity. These specimens were also used to assess the repair weld metal and original fabrication weldment toughness properties

43

Effect of neutron irradiation on the dynamic fracture toughness behavior of the 12% Cr steel MANET-I investigated using subsize V-notch specimens  

Science.gov (United States)

The effect of neutron irradiation on the dynamic fracture toughness behaviour of the 12% Cr steel MANET-I was investigated using DIN 50115-KLST, subsize, V-notch impact bend specimens (3 × 4 × 27 mm3). The microstructure of the steel was varied by employing different quenching and austenizing conditions. The specimens were irradiated in the HFR Petten at 300, 400, and 475°C to displacement damage levels as high as 5 dpaNRT. Experimental results are reported from an ongoing program aimed at determining the influence of irradiation-induced microstructural changes on the impact properties of MANET-I: the ductile-to-brittle transition temperature (DBTT), the relative fracture toughness, and the dynamic plane strain fracture toughness. Following irradiation a large increase in the DBTT and a remarkable decrease in the upper-shelf energy (USE) were observed. The changes in the properties depend strongly on the irradiation temperature. The DBTT and USE of the irradiated specimens also depend clearly on the initial microstructure of the material. The increase in DBTT and the decrease in USE are in general greater at 300 than at 400 and 475°C. Under proper conditions the instrumented impact test can be used to determine the dynamic plane strain fracture toughness K1d and the J-integral of unirradiated and irradiated materials.

Wassilew, Christo; Ehrlich, Karl

1992-09-01

44

Effect of neutron irradiation on the dynamic fracture toughness behaviour of the 12% Cr steel MANET-I investigated using subsize V-notch specimens  

International Nuclear Information System (INIS)

The effect of neutron irradiation on the dynamic fracture toughness behaviour of the 12% Cr steel MANET-I was investigated using DIN 50115-KLST, subsize, V-notch impact bend specimens (3x4x27 mm3). The microstructure of the steel was varied by employing different quenching and austenizing conditions. The specimens were irradiated in the HFR Petten at 300, 400, and 475deg C to displacement damage levels as high as 5 dpaNRT. Experimental results are reported from an ongoing program aimed at determining the influcene of irradiation-induced microstructural changes on the impact properties of MANET-I: The ductile-to-brittle transition temperature (DBTT), the relative fracture toughness, and the dynamic plane strain fracture toughness. Following irradiation a large increase in the DBTT and a remarkable decrease in the upper-shelf energy (USE) were observed. The changes in the properties depend strongly on the irradiation temperature. The DBTT and USE of the irradiated specimens also depend clearly on the initial microstructure of the material. The increase in DBTT and the decrease in USE are in general greater at 300 than at 400 and 475deg C. Under proper conditions the instrumented impact test can be used to determine the dynamic plane strain fracture toughness K1d and the J-integral of unirradiated and irradiated materials. (orig.)

45

Preparation of reconstituted Charpy V-notch impact specimens for generating pressure vessel steel fracture toughness data  

International Nuclear Information System (INIS)

The arc stud welding process has been adapted for use in producing reconstituted Charpy V-notch impact specimens. In this process, each half of a tested and fractured Charpy specimen is used as the central region of a reconstituted specimen. End tabs are joined to one half of a fractured specimen by a specially designed stud welding apparatus. SA533B-1 and SA508-2 unirradiated and irradiated pressure vessel steel specimens have been produced. Both conventional and precracked reconstituted specimen data have been produced. Both types of data have been shown to be in excellent agreement with original specimen data. The arc stud welding process can therefore be used to increase the amount of data obtainable from a limited number of specimens or to obtain Charpy data when full size specimens cannot otherwise be obtained

46

Assessment of temper embrittlement in an ex-service 1Cr-1Mo-0.25V power generating rotor by Charpy V-Notch testing, KIc fracture toughness and small punch test  

International Nuclear Information System (INIS)

This paper presents the results of the research aimed at developing fracture toughness correlations for the purposes of the remaining life assessment of an ex-service 1Cr-1Mo-0.25V power-generating rotor. Results from three methods of measuring the fracture toughness are presented and discussed: Charpy V-Notch testing, small punch testing and full size KIc testing. Samples were taken at three locations from a retired HP-IP rotor. De-embrittling and re-embrittling heat treatments were performed to generate three sets of samples: service-exposed, de-embrittled and re-embrittled. These samples were used to study the effect of temper embrittlement, a damage mechanism that reduces toughness of components in service. The correlations applied to the experimental data indicated advantages of using the small punch test as a miniature specimen technique for the remaining life assessment of low alloy steel rotors

47

Computer simulation of plastic deformation in the Charpy V-notch impact test  

International Nuclear Information System (INIS)

Calculations describe the dynamic stress and strain states in the standard Charpy specimen from impact to the start of cracking. We model A533 Grade B Class 1 nuclear-pressure-vessel steel at 1000C with an elastic-plastic constitutive law. Large deformation and rotation of the material are accounted for. The specimen velocity field during the impact transient is presented and how the early wave effects cause separation of the specimen from the striker is shown. The calculations show why correlations between Charpy fracture energy and fracture toughness have been largely unsuccessful and suggest methods to improve these correlations using the same specimen geometry

48

Confocal microscopy-fracture reconstruction and finite element modeling characterization of local cleavage toughness in a ferritic/martensitic steel in subsized Charpy V-notch impact tests  

International Nuclear Information System (INIS)

The confocal microscopy (CM)-fracture reconstruction (FR) method, coupled with scanning electron microscopy (SEM) fractography, was used to measure the critical notch deformation conditions at cleavage initiation for two subsized Charpy V-notch (CVN) specimen geometries of Japan ferritic/martensitic steel (JFMS). A new method was developed to permit FR of notched specimens. Three-dimensional finite element analysis (FEA) simulations of the notch and specimen deformation were used to estimate values of critical micro-cleavage fracture stress, ?*, and critical stressed area, A*. Since ?*-A* is independent of size and geometry, it provides a fundamental local measure of cleavage toughness

49

Confocal microscopy?fracture reconstruction and finite element modeling characterization of local cleavage toughness in a ferritic/martensitic steel in subsized Charpy V-notch impact tests  

Science.gov (United States)

The confocal microscopy (CM)-fracture reconstruction (FR) method, coupled with scanning electron microscopy (SEM) fractography, was used to measure the critical notch deformation conditions at cleavage initiation for two subsized Charpy V-notch (CVN) specimen geometries of Japan ferritic/martensitic steel (JFMS). A new method was developed to permit FR of notched specimens. Three-dimensional finite element analysis (FEA) simulations of the notch and specimen deformation were used to estimate values of critical micro-cleavage fracture stress, ? ?, and critical stressed area, A ?. Since ? ?-A ? is independent of size and geometry, it provides a fundamental local measure of cleavage toughness.

Yamamoto, T.; Odette, G. R.; Lucas, G. E.; Matsui, H.

2000-12-01

50

Confocal microscopy-fracture reconstruction and finite element modeling characterization of local cleavage toughness in a ferritic/martensitic steel in subsized Charpy V-notch impact tests  

Energy Technology Data Exchange (ETDEWEB)

The confocal microscopy (CM)-fracture reconstruction (FR) method, coupled with scanning electron microscopy (SEM) fractography, was used to measure the critical notch deformation conditions at cleavage initiation for two subsized Charpy V-notch (CVN) specimen geometries of Japan ferritic/martensitic steel (JFMS). A new method was developed to permit FR of notched specimens. Three-dimensional finite element analysis (FEA) simulations of the notch and specimen deformation were used to estimate values of critical micro-cleavage fracture stress, {sigma}{sup *}, and critical stressed area, A{sup *}. Since {sigma}{sup *}-A{sup *} is independent of size and geometry, it provides a fundamental local measure of cleavage toughness.

Yamamoto, T. E-mail: yamataku@fusion.imr.tohoku.ac.jp; Odette, G.R.; Lucas, G.E.; Matsui, H

2000-12-01

51

NIH trial shows promising results in treating a lymphoma in young people  

Science.gov (United States)

Patients with a type of cancer known as primary mediastinal B-cell lymphoma who received infusions of chemotherapy, but who did not have radiation therapy to an area of the thorax known as the mediastinum, had excellent outcomes, according to clinical trial results.

52

Trial results show high remission rate in leukemia following immune cell therapy  

Science.gov (United States)

Children and young adults (age 1 to age 30) with chemotherapy-resistant B-cell acute lymphoblastic leukemia (ALL) experienced high remission rates following treatment with an experimental immunotherapy. Results demonstrated that the immunotherapy treatment had anti-leukemia effects in patients and that the treatment was feasible and safe.

53

Resolving relationship tests that show ambiguous STR results using autosomal SNPs as supplementary markers.  

Science.gov (United States)

When using a standard battery of STRs for relationship testing a small proportion of analyses can give ambiguous results - where the claimed relationship cannot be confirmed by a high enough paternity index or excluded with fully incompatible genotypes. The majority of such cases arise from unknowingly testing a brother of the true father and observing only a small number of exclusions that can each be interpreted as one- or two-step mutations. Although adding extra STRs might resolve a proportion of cases, there are few properly validated extra STRs available, while the commonly added hypervariable SE33 locus is four times more mutable than average, increasing the risk of ambiguous results. We have found SNPs in large multiplexes are much more informative for both low initial probabilities or ambiguous exclusions and at the same time provide a more reliable genotyping approach for the highly degraded DNA encountered in many identification cases. Eight relationship cases are outlined where the addition of SNP data resolved analyses that had remained ambiguous even with extended STR typing. In addition we have made simulations to ascertain the frequency of failing to obtain exclusions or conclusive probabilities of paternity with different marker sets when a brother of the true father is tested. Results indicate that SNPs are statistically more efficient than STRs in resolving cases that distinguish first-degree relatives in deficient pedigrees. PMID:19083821

Phillips, C; Fondevila, M; García-Magariños, M; Rodriguez, A; Salas, A; Carracedo, A; Lareu, M V

2008-06-01

54

Lung cancer trial results show mortality benefit with low-dose CT:  

Science.gov (United States)

The NCI has released initial results from a large-scale test of screening methods to reduce deaths from lung cancer by detecting cancers at relatively early stages. The National Lung Screening Trial, a randomized national trial involving more than 53,000 current and former heavy smokers ages 55 to 74, compared the effects of two screening procedures for lung cancer -- low-dose helical computed tomography (CT) and standard chest X-ray -- on lung cancer mortality and found 20 percent fewer lung cancer deaths among trial participants screened with low-dose helical CT.

55

Results From Mars Show Electrostatic Charging of the Mars Pathfinder Sojourner Rover  

Science.gov (United States)

Indirect evidence (dust accumulation) has been obtained indicating that the Mars Pathfinder rover, Sojourner, experienced electrostatic charging on Mars. Lander camera images of the Sojourner rover provide distinctive evidence of dust accumulation on rover wheels during traverses, turns, and crabbing maneuvers. The sol 22 (22nd Martian "day" after Pathfinder landed) end-of-day image clearly shows fine red dust concentrated around the wheel edges with additional accumulation in the wheel hubs. A sol 41 image of the rover near the rock "Wedge" (see the next image) shows a more uniform coating of dust on the wheel drive surfaces with accumulation in the hubs similar to that in the previous image. In the sol 41 image, note particularly the loss of black-white contrast on the Wheel Abrasion Experiment strips (center wheel). This loss of contrast was also seen when dust accumulated on test wheels in the laboratory. We believe that this accumulation occurred because the Martian surface dust consists of clay-sized particles, similar to those detected by Viking, which have become electrically charged. By adhering to the wheels, the charged dust carries a net nonzero charge to the rover, raising its electrical potential relative to its surroundings. Similar charging behavior was routinely observed in an experimental facility at the NASA Lewis Research Center, where a Sojourner wheel was driven in a simulated Martian surface environment. There, as the wheel moved and accumulated dust (see the following image), electrical potentials in excess of 100 V (relative to the chamber ground) were detected by a capacitively coupled electrostatic probe located 4 mm from the wheel surface. The measured wheel capacitance was approximately 80 picofarads (pF), and the calculated charge, 8 x 10(exp -9) coulombs (C). Voltage differences of 100 V and greater are believed sufficient to produce Paschen electrical discharge in the Martian atmosphere. With an accumulated net charge of 8 x 10(exp -9) C, and average arc time of 1 msec, arcs can also occur with estimated arc currents approaching 10 milliamperes (mA). Discharges of this magnitude could interfere with the operation of sensitive electrical or electronic elements and logic circuits. Sojourner rover wheel tested in laboratory before launch to Mars. Before launch, we believed that the dust would become triboelectrically charged as it was moved about and compacted by the rover wheels. In all cases observed in the laboratory, the test wheel charged positively, and the wheel tracks charged negatively. Dust samples removed from the laboratory wheel averaged a few ones to tens of micrometers in size (clay size). Coarser grains were left behind in the wheel track. On Mars, grain size estimates of 2 to 10 mm were derived for the Martian surface materials from the Viking Gas Exchange Experiment. These size estimates approximately match the laboratory samples. Our tentative conclusion for the Sojourner observations is that fine clay-sized particles acquired an electrostatic charge during rover traverses and adhered to the rover wheels, carrying electrical charge to the rover. Since the Sojourner rover carried no instruments to measure this mission's onboard electrical charge, confirmatory measurements from future rover missions on Mars are desirable so that the physical and electrical properties of the Martian surface dust can be characterized. Sojourner was protected by discharge points, and Faraday cages were placed around sensitive electronics. But larger systems than Sojourner are being contemplated for missions to the Martian surface in the foreseeable future. The design of such systems will require a detailed knowledge of how they will interact with their environment. Validated environmental interaction models and guidelines for the Martian surface must be developed so that design engineers can test new ideas prior to cutting hardware. These models and guidelines cannot be validated without actual flighata. Electrical charging of vehicles and, one day, astronauts moving across t

Kolecki, Joseph C.; Siebert, Mark W.

1998-01-01

56

Updated clinical results show experimental agent ibrutinib as highly active in CLL patients  

Science.gov (United States)

Updated results from a Phase Ib/II clinical trial led by the Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute indicates that a novel therapeutic agent for chronic lymphocytic leukemia (CLL) is highly active and well tolerated in patients who have relapsed and are resistant to other therapy. The agent, ibrutinib (PCI-32765), is the first drug designed to target Bruton's tyrosine kinase (BTK), a protein essential for CLL-cell survival and proliferation. CLL is the most common form of leukemia, with about 15,000 new cases annually in the U.S. About 4,400 Americans die of the disease each year.

57

Regional Trial Results Show Wheat Yield Declining in the Eastern Gangetic Plains Of South Asia  

Directory of Open Access Journals (Sweden)

Full Text Available A study was undertaken at 9 to 11 sites in seven years (2000-2006 in the Eastern Gangetic Plains (EGP to examine yield trend through optimum managed wheat crop in the region using 21 experimental lines and four checks (Bhrikuti, PBW343, Kanchan and Sonalika. Data on grain yield, 1000-kernel weight (TKW, spot blotch severity, maturity and plant height were analyzed. Trend analysis revealed decreasing trend in grain yield and TKW. Spot blotch (Cochliobolus sativus severity has increased over this period. Results indicate an effect of spot blotch severity on the reductions in grain yield and TKW. These findings have direct implications for developing strategies to improve wheat yields in the EGP region.

R.C. Sharma

2007-01-01

58

FES Training in Aging: interim results show statistically significant improvements in mobility and muscle fiber size  

Directory of Open Access Journals (Sweden)

Full Text Available Aging is a multifactorial process that is characterized by decline in muscle mass and performance. Several factors, including reduced exercise, poor nutrition and modified hormonal metabolism, are responsible for changes in the rates of protein synthesis and degradation that drive skeletal muscle mass reduction with a consequent decline of force generation and mobility functional performances. Seniors with normal life style were enrolled: two groups in Vienna (n=32 and two groups in Bratislava: (n=19. All subjects were healthy and declared not to have any specific physical/disease problems. The two Vienna groups of seniors exercised for 10 weeks with two different types of training (leg press at the hospital or home-based functional electrical stimulation, h-b FES. Demografic data (age, height and weight were recorded before and after the training period and before and after the training period the patients were submitted to mobility functional analyses and muscle biopsies. The mobility functional analyses were: 1. gait speed (10m test fastest speed, in m/s; 2. time which the subject needed to rise from a chair for five times (5x Chair-Rise, in s; 3. Timed –Up-Go- Test, in s; 4. Stair-Test, in s; 5. isometric measurement of quadriceps force (Torque/kg, in Nm/kg; and 6. Dynamic Balance in mm. Preliminary analyses of muscle biopsies from quadriceps in some of the Vienna and Bratislava patients present morphometric results consistent with their functional behaviors. The statistically significant improvements in functional testings here reported demonstrates the effectiveness of h-b FES, and strongly support h-b FES, as a safe home-based method to improve contractility and performances of ageing muscles.

Helmut Kern

2012-06-01

59

Effects of oxidation on the impact energy of Hastelloy S and Hastelloy C-4 Charpy V-notch specimens heated in air at 6000 to 8000C  

International Nuclear Information System (INIS)

The 90SrF2 heat source being developed at PNL utilizes a Hastelloy S or Hastelloy C-4 outer capsule having a 0.5-in.-thick wall to contain the Hastelloy C-276 inner capsule. The primary objective of the study was to demonstrate that the air oxidation of the outer capsule that could occur during heat-source service would not degrade the ductility and Charpy impact strength of the capsule below the licensing requirements given in Section 1.1. The 90SrF2 heat source under development is intended for general-purpose use. Compatibility considerations limit the interface temperature between the 90SrF2 and Hastelloy C-276 inner capsule to a maximum of 8000C. The outer capsule surface temperature will be somewhat less than 8000C, and depending on the service, may be substantially lower. The oxidation tests were therefore carried out at 6000 to 8000C for exposures up to 10,000h to cover the range of temperature the outer capsule might expect to encounter in service. The results showed that the oxidation of Hastelloy S and Hastelloy C-4 in air at 6000 to 8000C is very slow, and both alloys form adherent oxide layers that serve to protect the underlying metal. Subsurface attack of Hastelloy S and Hastelloy C-4 due to oxidation was greater than expected, considering the slow oxidation rates of the two alloys at 6000 to 8000C. Estimates of subsurface attack, determined from micrographs of the oxidized specimens, showed erratic results and it was impossible to assign any type of rate equation to the subsurface attack. A conservative estimate of long-term effects can be made using a linear extrapolation of the test results. There were no significant differences between the room-temperature Charpy impact energy of Hastelloy S and Hastelloy C-4 specimens oxidized in air at 6000 to 8000C and control specimens heated in vacuum

60

Recombinant PNPLA3 protein shows triglyceride hydrolase activity and its I148M mutation results in loss of function.  

Science.gov (United States)

The patatin-like phospholipase domain containing 3 (PNPLA3, also called adiponutrin, ADPN) is a membrane-bound protein highly expressed in the liver. The genetic variant I148M (rs738409) was found to be associated with progression of chronic liver disease. We aimed to establish a protein purification protocol in a yeast system (Pichia pastoris) and to examine the human PNPLA3 enzymatic activity, substrate specificity and the I148M mutation effect. hPNPLA3 148I wild type and 148M mutant cDNA were cloned into P. pastoris expression vectors. Yeast cells were grown in 3L fermentors. PNPLA3 protein was purified from membrane fractions by Ni-affinity chromatography. Enzymatic activity was assessed using radiolabeled substrates. Both 148I wild type and 148M mutant proteins are localized to the membrane. The wild type protein shows a predominant lipase activity with mild lysophosphatidic acid acyl transferase activity (LPAAT) and the I148M mutation results in a loss of function of both these activities. Our data show that PNPLA3 has a predominant lipase activity and I148M mutation results in a loss of function. PMID:24369119

Pingitore, Piero; Pirazzi, Carlo; Mancina, Rosellina M; Motta, Benedetta M; Indiveri, Cesare; Pujia, Arturo; Montalcini, Tiziana; Hedfalk, Kristina; Romeo, Stefano

2014-04-01

 
 
 
 
61

A brittle fracture criterion for PMMA V-notches tensile specimens based on a length-enriched eXtended Finite Element approach  

Directory of Open Access Journals (Sweden)

Full Text Available A criterion for the prediction of the static failure loads in tensile PMMA specimens with sharp notches is presented. The proposed criterion is based on a regularized version of the eXtended Finite Element Method (XFEM, which has been previously applied to concrete-like materials. The main feature of the proposed approach is that the cracking process is not treated as a local process, but it is modeled by assuming that macro-cracks stem from the interaction of micro-cracks within a finite width process zone. The case of a brittle materials with thin process zone is tackled by assuming one layer of enriched finite elements. Preliminary results concerning PMMA specimens subjected to mode-one loading are presented.

P. Livieri

2011-07-01

62

Transgenic plants expressing HC-Pro show enhanced virus sensitivity while silencing of the transgene results in resistance.  

Science.gov (United States)

Nicotiana benthamiana plants were engineered to express sequences of the helper component-proteinase (HC-Pro) of Cowpea aphid-borne mosaic potyvirus (CABMV). The sensitivity of the transgenic plants to infection with parental and heterologous viruses was studied. The lines expressing HC-Pro showed enhanced symptoms after infection with the parental CABMV isolate and also after infection with a heterologous potyvirus, Potato virus Y (PVY) and a comovirus, Cowpea mosaic virus (CPMV). On the other hand, transgenic lines expressing nontranslatable HC-Pro or translatable HC-Pro with a deletion of the central domain showed wild type symptoms after infection with the parental CABMV isolate and heterologous viruses. These results showed that CABMV HC-Pro is a pathogenicity determinant that conditions enhanced sensitivity to virus infection in plants, and that the central domain of the protein is essential for this. The severe symptoms in CABMV-infected HC-Pro expressing lines were remarkably followed by brief recovery and subsequent re-establishment of infection, possibly indicating counteracting effects of HC-Pro expression and a host defense response. One of the HC-Pro expressing lines (h48) was found to contain low levels of transgenic HC-Pro RNA and to be resistant to CABMV and to recombinant CPMV expressing HC-Pro. This indicated that h48 was (partially) posttranscriptionally silenced for the HC-Pro transgene inspite of the established role of HC-Pro as a suppressor of posttranscriptional gene silencing. Line h48 was not resistant to PVY, but instead showed enhanced symptoms compared to nontransgenic plants. This may be due to relief of silencing of the HC-Pro transgene by HC-Pro expressed by PVY. PMID:12206307

Mlotshwa, Sizolwenkosi; Verver, Jan; Sithole-Niang, Idah; Prins, Marcel; Van Kammen, A B; Wellink, Joan

2002-01-01

63

Transgenic plants expressing HC-Pro show enhanced virus sensitivity while silencing of the transgene results in resistance  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Nicotiana benthamiana plants were engineered to express sequences of the helper component-proteinase (HC-Pro) of Cowpea aphid-borne mosaic potyvirus (CABMV). The sensitivity of the transgenic plants to infection with parental and heterologous viruses was studied. The lines expressing HC-Pro showed enhanced symptoms after infection with the parental CABMV isolate and also after infection with a heterologous potyvirus, Potato virus Y (PVY) and a comovirus, Cowpea mosaic virus (CPMV). On the oth...

Mlotshwa, S.; Verver, J.; Sithole-niang, I.; Prins, M.; Kammen, A.; Wellink, J.

2002-01-01

64

Reception of Talent Shows in Denmark: First Results from a Trans-National Audience Study of a Global Format Genre  

DEFF Research Database (Denmark)

This paper will discuss the methodology and present the preliminary findings of the Danish part of a trans-national, comparative audience study of the musical talent show genre undertaken in Denmark, Finland, Germany and Great Britain in Spring 2013. Within the international business model of format adaptation, the musical talent show genre has been particularly successful in crossing cultural borders. Formats such as Idols, X Factor and Voice have sold to a large variety of countries, covering all continents. Such global reach inevitably raises the question of the genre’s audience appeal; to what degree its reach has to do with a universal appeal inherent in the genre and/or the innovative character of individual formats, and to what degree its global success is due to local broadcasters’ ability to successfully adapt the formats to local audience tastes. A consensus has developed that television formats to a considerable degree are adapted according to national audiences and, hence, national cultural tastes. And in our research approach, we do recognize that musical talent shows appear to contribute to ‘imagining the nation’ (Anderson 1983), often even mentioning the nation in the title. However, we also take into account that the national perspective needs to be considered critically. First, there are other factors but national culture that determine a local adaptation such as subnational target groups, channel identity, financing or chance incidents. Secondly, it has rightly been argued that within any national television market, especially in the post-broadcast era, a multiplicity of publics co-exists. The aim of the focus groups is therefore to shed light on the complexity of the communal viewing experience, real and imagined, national, sub-national and transnational; of identification, and of the meaning that viewers take from the musical talent show genre.

Jensen, Pia Majbritt

65

Resistin polymorphisms show associations with obesity, but not with bone parameters in men : results from the Odense Androgen Study  

DEFF Research Database (Denmark)

Resistin is an obesity-related adipokine which has also been implicated in bone metabolism. Therefore, we designed a study to investigate the possible role of resistin gene variation in both obesity and bone mineral density. We included 1,155 individuals from the Odense Androgen Study (663 young subjects and 492 older subjects), a population-based, prospective, observational study on the inter-relationship between endocrine status, body composition, muscle function, and bone metabolism in men, in an association study with resistin (RETN) polymorphisms. Three RETN variants (rs1862513, rs3745367 and rs3745369) were genotyped with TaqMan Pre-Designed Genotyping assays. Linear regression was performed to investigate the possible association of these variants with several obesity- and bone-related parameters. After genotyping 1,155 Danish men, 663 young subjects and 492 older subjects, we found that rs3745367 was associated with several obesity-related measures in both the young and elderly cohort. Rs3745369 was only associated with obesity-phenotypes in the elderly cohort. When studying the combined cohorts, we could confirm the associations of rs3745367 with several obesity-related parameters. We were unable to identify any association between RETN polymorphisms and bone-related measurements. Together, these results illustrate resistin's role in the development of obesity. Rs3745367 gives the most consistent results in the current study and these should be confirmed in other populations. Research into its possible functional effect might also be required. A role for RETN variants in determining bone mineral density seems unlikely from our results.

Beckers, Sigri; Zegers, Doreen

2013-01-01

66

Sci Show  

Science.gov (United States)

The Sci Show, an entertaining series of quirky YouTube videos, tackles topics ranging from âÂÂHow Do Polarized Sunglasses Workâ to âÂÂStrong Interaction: The Four Fundamental Forces of Physics.â Most episodes are less than five minutes long, but they pack a wallop of handy science info. Anyone short on time but long on big questions will benefit from the series. Episodes will be helpful to teachers and parents looking to spark enthusiasm in young minds. Viewers may want to start with recent episodes like âÂÂTodayâÂÂs Mass Extinction,â and the âÂÂWorldâÂÂs First See-Through Animalâ and âÂÂHow Do Animals Change Color?â before digging into the archives for gems like âÂÂThe Truth About Gingersâ and âÂÂThe Science of Lying.âÂÂ

67

Simple instruments used in monitoring ionospheric perturbations and some observational results showing the ionospheric responses to the perturbations mainly from the lower atmosphere  

Science.gov (United States)

Ionospheric disturbances such as SID and acoustic gravity waves in different scales are well known and commonly discussed topics. Some simple ground equipment was designed and used for monitoring continuously the effects of these disturbances, especially, SWF, SFD. Besides SIDs, They also reflect clearly the acoustic gravity waves in different scale and Spread-F and these data are important supplementary to the traditional ionosonde records. It is of signifi-cance in understanding physical essentials of the ionospheric disturbances and applications in SID warning. In this paper, the designing of the instruments is given and results are discussed in detail. Some case studies were introduced as example which showed very clearly not only immediate effects of solar flare, but also the phenomena of ionospheric responses to large scale gravity waves from lower atmosphere such as typhoon, great earthquake and volcano erup-tion. Particularlyresults showed that acoustic gravity waves play significant role in seeding ionospheric Spread-F. These examples give evidence that lower atmospheric activities strongly influence the ionosphere.

Xiao, Zuo; Hao, Yongqiang; Zhang, Donghe; Xiao, Sai-Guan; Huang, Weiquan

68

How often do German children and adolescents show signs of common mental health problems? Results from different methodological approaches - a cross-sectional study  

Science.gov (United States)

Background Child and adolescent mental health problems are ubiquitous and burdensome. Their impact on functional disability, the high rates of accompanying medical illnesses and the potential to last until adulthood make them a major public health issue. While methodological factors cause variability of the results from epidemiological studies, there is a lack of prevalence rates of mental health problems in children and adolescents according to ICD-10 criteria from nationally representative samples. International findings suggest only a small proportion of children with function impairing mental health problems receive treatment, but information about the health care situation of children and adolescents is scarce. The aim of this epidemiological study was a) to classify symptoms of common mental health problems according to ICD-10 criteria in order to compare the statistical and clinical case definition strategies using a single set of data and b) to report ICD-10 codes from health insurance claims data. Methods a) Based on a clinical expert rating, questionnaire items were mapped on ICD-10 criteria; data from the Mental Health Module (BELLA study) were analyzed for relevant ICD-10 and cut-off criteria; b) Claims data were analyzed for relevant ICD-10 codes. Results According to parent report 7.5% (n?=?208) met the ICD-10 criteria of a mild depressive episode and 11% (n?=?305) showed symptoms of depression according to cut-off score; Anxiety is reported in 5.6% (n?=?156) and 11.6% (n?=?323), conduct disorder in 15.2% (n?=?373) and 14.6% (n?=?357). Self-reported symptoms in 11 to 17 year olds resulted in 15% (n?=?279) reporting signs of a mild depression according to ICD-10 criteria (vs. 16.7% (n?=?307) based on cut-off) and 10.9% (n?=?201) reported symptoms of anxiety (vs. 15.4% (n?=?283)). Results from routine data identify 0.9% (n?=?1,196) with a depression diagnosis, 3.1% (n?=?6,729) with anxiety and 1.4% (n?=?3,100) with conduct disorder in outpatient health care. Conclusions Statistical and clinical case definition strategies show moderate concordance in depression and conduct disorder in a German national sample. Comparatively, lower rates of children and adolescents with diagnosed mental health problems in the outpatient health care setting support the assumptions that a small number of children and adolescents in need of treatment receive it. PMID:24597565

2014-01-01

69

Results of crack-arrest tests on two irradiated high-copper welds  

Energy Technology Data Exchange (ETDEWEB)

The objective of this study was to determine the effect of neutron irradiation on the shift and shape of the lower-bound curve to crack-arrest data. Two submerged-arc welds with copper contents of 0.23 and 0.31 wt % were commercially fabricated in 220-mm-thick plate. Crack-arrest specimens fabricated from these welds were irradiated at a nominal temperature of 288{degree}C to an average fluence of 1.9 {times} 10{sup 19} neutrons/cm{sup 2} (>1 MeV). Evaluation of the results shows that the neutron-irradiation-induced crack-arrest toughness temperature shift is about the same as the Charpy V-notch impact temperature shift at the 41-J energy level. The shape of the lower-bound curves (for the range of test temperatures covered) did not seem to have been altered by irradiation compared to those of the ASME K{sub Ia} curve. 9 refs., 21 figs., 10 tabs.

Iskander, S.K.; Corwin, W.R.; Nanstead, R.K. (Oak Ridge National Lab., TN (USA))

1990-12-01

70

Storytelling Slide Shows to Improve Diabetes and High Blood Pressure Knowledge and Self-Efficacy: Three-Year Results among Community Dwelling Older African Americans  

Science.gov (United States)

This study combined the African American tradition of oral storytelling with the Hispanic medium of "Fotonovelas." A staggered pretest posttest control group design was used to evaluate four Storytelling Slide Shows on health that featured community members. A total of 212 participants were recruited for the intervention and 217 for the…

Bertera, Elizabeth M.

2014-01-01

71

Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs.  

Science.gov (United States)

The maintenance of cellular levels of free fatty acids and acyl-CoAs, the activated form of free fatty acids, is extremely important, as imbalances in lipid metabolism have serious consequences for human health. Acyl-coenzyme A (CoA) thioesterases (ACOTs) hydrolyze acyl-CoAs to the free fatty acid and CoASH, and thereby have the potential to regulate intracellular levels of these compounds. We previously identified and characterized a mouse ACOT gene cluster comprised of six genes that apparently arose by gene duplications encoding acyl-CoA thioesterases with localizations in cytosol (ACOT1), mitochondria (ACOT2), and peroxisomes (ACOT3-6). However, the corresponding human gene cluster contains only three genes (ACOT1, ACOT2, and ACOT4) coding for full-length thioesterase proteins, of which only one is peroxisomal (ACOT4). We therefore set out to characterize the human genes, and we show here that the human ACOT4 protein catalyzes the activities of three mouse peroxisomal ACOTs (ACOT3, 4, and 5), being active on succinyl-CoA and medium to long chain acyl-CoAs, while ACOT1 and ACOT2 carry out similar functions to the corresponding mouse genes. These data strongly suggest that the human ACOT4 gene has acquired the functions of three mouse genes by a functional convergent evolution that also provides an explanation for the unexpectedly low number of human genes. PMID:16940157

Hunt, Mary C; Rautanen, Anna; Westin, Maria A K; Svensson, L Thomas; Alexson, Stefan E H

2006-09-01

72

Value of Fused 18F-Choline-PET/MRI to Evaluate Prostate Cancer Relapse in Patients Showing Biochemical Recurrence after EBRT: Preliminary Results  

Science.gov (United States)

Purpose. We compared the accuracy of 18F-Choline-PET/MRI with that of multiparametric MRI (mMRI), 18F-Choline-PET/CT, 18F-Fluoride-PET/CT, and contrast-enhanced CT (CeCT) in detecting relapse in patients with suspected relapse of prostate cancer (PC) after external beam radiotherapy (EBRT). We assessed the association between standard uptake value (SUV) and apparent diffusion coefficient (ADC). Methods. We evaluated 21 patients with biochemical relapse after EBRT. Patients underwent 18F-Choline-PET/contrast-enhanced (Ce)CT, 18F-Fluoride-PET/CT, and mMRI. Imaging coregistration of PET and mMRI was performed. Results. 18F-Choline-PET/MRI was positive in 18/21 patients, with a detection rate (DR) of 86%. DRs of 18F-Choline-PET/CT, CeCT, and mMRI were 76%, 43%, and 81%, respectively. In terms of DR the only significant difference was between 18F-Choline-PET/MRI and CeCT. On lesion-based analysis, the accuracy of 18F-Choline-PET/MRI, 18F-Choline-PET/CT, CeCT, and mMRI was 99%, 95%, 70%, and 85%, respectively. Accuracy, sensitivity, and NPV of 18F-Choline-PET/MRI were significantly higher than those of both mMRI and CeCT. On whole-body assessment of bone metastases, the sensitivity of 18F-Choline-PET/CT and 18F-Fluoride-PET/CT was significantly higher than that of CeCT. Regarding local and lymph node relapse, we found a significant inverse correlation between ADC and SUV-max. Conclusion. 18F-Choline-PET/MRI is a promising technique in detecting PC relapse. PMID:24877053

Piccardo, Arnoldo; Paparo, Francesco; Picazzo, Riccardo; Naseri, Mehrdad; Ricci, Paolo; Marziano, Andrea; Bacigalupo, Lorenzo; Biscaldi, Ennio; Rollandi, Gian Andrea; Grillo-Ruggieri, Filippo; Farsad, Mohsen

2014-01-01

73

Solar Light Show  

Science.gov (United States)

Over the last few days, the Earth has been buffeted by a geomagnetic storm caused by a major solar flare. In addition to disruptions in radio, telecommunications, and electric service, the flare may also produce a dramatic light show as it peaks tonight. Weather permitting, the aurora borealis, or northern lights, may be visible as far south as Washington, D.C. The best viewing time will be local midnight. The sun is currently at the peak of its eleven-year solar cycle, spawning flares and "coronal mass ejections" (CME), violent outbursts of gas from the sun's corona that can carry up to 10 billion tons of electrified gas traveling at speeds as high as 2000 km/s. Geomagnetic storms result when solar winds compress the magnetosphere, sometimes interfering with electric power transmission and satellites, but also creating beautiful aurorae, as many stargazers hope will occur tonight.

De Nie, Michael W.

74

Television Quiz Show Simulation  

Science.gov (United States)

This article explores the simulation of four television quiz shows for students in China studying English as a foreign language (EFL). It discusses the adaptation and implementation of television quiz shows and how the students reacted to them.

Hill, Jonnie Lynn

2007-01-01

75

The Great Cometary Show  

Science.gov (United States)

The ESO Very Large Telescope Interferometer, which allows astronomers to scrutinise objects with a precision equivalent to that of a 130-m telescope, is proving itself an unequalled success every day. One of the latest instruments installed, AMBER, has led to a flurry of scientific results, an anthology of which is being published this week as special features in the research journal Astronomy & Astrophysics. ESO PR Photo 06a/07 ESO PR Photo 06a/07 The AMBER Instrument "With its unique capabilities, the VLT Interferometer (VLTI) has created itself a niche in which it provide answers to many astronomical questions, from the shape of stars, to discs around stars, to the surroundings of the supermassive black holes in active galaxies," says Jorge Melnick (ESO), the VLT Project Scientist. The VLTI has led to 55 scientific papers already and is in fact producing more than half of the interferometric results worldwide. "With the capability of AMBER to combine up to three of the 8.2-m VLT Unit Telescopes, we can really achieve what nobody else can do," added Fabien Malbet, from the LAOG (France) and the AMBER Project Scientist. Eleven articles will appear this week in Astronomy & Astrophysics' special AMBER section. Three of them describe the unique instrument, while the other eight reveal completely new results about the early and late stages in the life of stars. ESO PR Photo 06b/07 ESO PR Photo 06b/07 The Inner Winds of Eta Carinae The first results presented in this issue cover various fields of stellar and circumstellar physics. Two papers deal with very young solar-like stars, offering new information about the geometry of the surrounding discs and associated outflowing winds. Other articles are devoted to the study of hot active stars of particular interest: Alpha Arae, Kappa Canis Majoris, and CPD -57o2874. They provide new, precise information about their rotating gas envelopes. An important new result concerns the enigmatic object Eta Carinae. Using AMBER with its high spatial and spectral resolution, it was possible to zoom into the very heart of this very massive star. In this innermost region, the observations are dominated by the extremely dense stellar wind that totally obscures the underlying central star. The AMBER observations show that this dense stellar wind is not spherically symmetric, but exhibits a clearly elongated structure. Overall, the AMBER observations confirm that the extremely high mass loss of Eta Carinae's massive central star is non-spherical and much stronger along the poles than in the equatorial plane. This is in agreement with theoretical models that predict such an enhanced polar mass-loss in the case of rapidly rotating stars. ESO PR Photo 06c/07 ESO PR Photo 06c/07 RS Ophiuchi in Outburst Several papers from this special feature focus on the later stages in a star's life. One looks at the binary system Gamma 2 Velorum, which contains the closest example of a star known as a Wolf-Rayet. A single AMBER observation allowed the astronomers to separate the spectra of the two components, offering new insights in the modeling of Wolf-Rayet stars, but made it also possible to measure the separation between the two stars. This led to a new determination of the distance of the system, showing that previous estimates were incorrect. The observations also revealed information on the region where the winds from the two stars collide. The famous binary system RS Ophiuchi, an example of a recurrent nova, was observed just 5 days after it was discovered to be in outburst on 12 February 2006, an event that has been expected for 21 years. AMBER was able to detect the extension of the expanding nova emission. These observations show a complex geometry and kinematics, far from the simple interpretation of a spherical fireball in extension. AMBER has detected a high velocity jet probably perpendicular to the orbital plane of the binary system, and allowed a precise and careful study of the wind and the shockwave coming from the nova. The stream of results from the VLTI and AMBER

2007-01-01

76

A Holographic Road Show.  

Science.gov (United States)

Describes the viewing sessions and the holograms of a holographic road show. The traveling exhibits, believed to stimulate interest in physics, include a wide variety of holograms and demonstrate several physical principles. (GA)

Kirkpatrick, Larry D.; Rugheimer, Mac

1979-01-01

77

Obesity in show cats.  

Science.gov (United States)

Obesity is an important disease with a high prevalence in cats. Because obesity is related to several other diseases, it is important to identify the population at risk. Several risk factors for obesity have been described in the literature. A higher incidence of obesity in certain cat breeds has been suggested. The aim of this study was to determine whether obesity occurs more often in certain breeds. The second aim was to relate the increased prevalence of obesity in certain breeds to the official standards of that breed. To this end, 268 cats of 22 different breeds investigated by determining their body condition score (BCS) on a nine-point scale by inspection and palpation, at two different cat shows. Overall, 45.5% of the show cats had a BCS > 5, and 4.5% of the show cats had a BCS > 7. There were significant differences between breeds, which could be related to the breed standards. Most overweight and obese cats were in the neutered group. It warrants firm discussions with breeders and cat show judges to come to different interpretations of the standards in order to prevent overweight conditions in certain breeds from being the standard of beauty. Neutering predisposes for obesity and requires early nutritional intervention to prevent obese conditions. PMID:24612018

Corbee, R J

2014-12-01

78

Show-Me Magazine  

Science.gov (United States)

Come along as the folks at the University of Missouri show you the history of their college days through the Show Me magazine. It's a wonderful collection of college humor published from 1946 to 1963. First-time visitors would do well to read about the magazine's colorful past, courtesy of Jerry Smith. A good place to start is the November 1920 issue (easily found when you browse by date), which contains a number of parody advertisements along with some doggerels poking good natured fun at the football team and an assortment of deans. Also, it's worth noting that visitors can scroll through issues and save them to an online "bookbag" for later use.

2008-01-01

79

Reality, ficción o show  

Directory of Open Access Journals (Sweden)

Full Text Available Para tener un punto de vista claro y objetivo frente a la polémica establecida en torno al programa ?Protagonistas de novela? y la tendiente proliferación de los reality show en las parrillas de programación de la televisión colombiana, se realizó un análisis de texto y contenido de dicho programa, intentando definirlo desde sus posibilidades de realidad, ficción y show. Las unidades de análisis y el estudio de su tratamiento arrojaron un alto contenido que gira en torno a las emociones del ser humano relacionadas con la convivencia, tratadas a manera de show y con algunos aportes textuales de ficción, pero sin su elemento mediador básico, el actor, quitándole toda la posibilidad de tener un tratamiento con la profundidad, distancia y ética que requieren los temas de esta índole. El resultado es un formato que sólo busca altos índices de sintonía y que pertenece más a la denominada televisión ?trash?, que a una búsqueda de realidad del hombre y mucho menos de sociedad.

Sandra Ru\\u00EDz Moreno

2002-01-01

80

Obesity in show dogs.  

Science.gov (United States)

Obesity is an important disease with a growing incidence. Because obesity is related to several other diseases, and decreases life span, it is important to identify the population at risk. Several risk factors for obesity have been described in the literature. A higher incidence of obesity in certain breeds is often suggested. The aim of this study was to determine whether obesity occurs more often in certain breeds. The second aim was to relate the increased prevalence of obesity in certain breeds to the official standards of that breed. To this end, we investigated 1379 dogs of 128 different breeds by determining their body condition score (BCS). Overall, 18.6% of the show dogs had a BCS >5, and 1.1% of the show dogs had a BCS>7. There were significant differences between breeds, which could be correlated to the breed standards. It warrants firm discussions with breeders and judges in order to come to different interpretations of the standards to prevent overweight conditions from being the standard of beauty. PMID:22882163

Corbee, R J

2012-08-11

 
 
 
 
81

HLA-DPB1 mismatching results in the generation of a full repertoire of HLA-DPB1-specific CD4+ T cell responses showing immunogenicity of all HLA-DPB1 alleles.  

Science.gov (United States)

Clinical studies have indicated that HLA-DPB1 functions as a classical transplantation antigen in allogeneic stem cell transplantation. Mismatching for HLA-DPB1 was associated with an increased risk of graft-versus-host disease (GVHD), but also a decreased risk of disease relapse. However, specific HLA-DPB1 mismatches were associated with poor clinical outcome. It was suggested that this unfavorable effect was caused by a difference in immunogenicity between HLA-DPB1 alleles. To analyze whether immunogenicity of HLA-DPB1 mismatches could be predicted based on the presence or absence of specific amino acid sequences we developed a model to generate allo-HLA-DPB1 responses in vitro. We tested in total 48 different stimulator/responder combinations by stimulating CD4(+) T cells from 5 HLA-DPB1 homozygous individuals with the same antigen-presenting cells transduced with different allo-HLA-DPB1 molecules. HLA-DPB1 molecules used for stimulation comprised 76% to 99% of HLA-DPB1 molecules present in different ethnic populations. We show that all HLA-DPB1 mismatches as defined by allele typing resulted in high-frequency immune responses. Furthermore, we show that crossrecognition of different HLA-DPB1 molecules is a broadly observed phenomenon. We confirm previously described patterns in crossrecognition, and demonstrate that a high degree in similarity between HLA-DPB1 molecules is predictive for crossrecognition, but not for immunogenicity. PMID:20350610

Rutten, Caroline E; van Luxemburg-Heijs, Simone A P; van der Meijden, Edith D; Griffioen, Marieke; Oudshoorn, Machteld; Willemze, Roel; Falkenburg, J H Frederik

2010-09-01

82

Dietary fiber showed no preventive effect against colon and rectal cancers in Japanese with low fat intake: an analysis from the results of nutrition surveys from 23 Japanese prefectures  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract Background Since Fuchs' report in 1999, the reported protective effect of dietary fiber from colorectal carcinogenesis has led many researchers to question its real benefit. The aim of this study is to evaluate the association between diet, especially dietary fiber and fat and colorectal cancer in Japan. Methods A multiple regression analysis (using the stepwise variable selection method was performed using the standardized mortality ratios (SMRs of colon and rectal cancer in 23 Japanese prefectures as objective variables and dietary fiber, nutrients and food groups as explanatory variables. Results As for colon cancer, the standardized partial correlation coefficients were positively significant for fat (1,13, P = 0.000, seaweeds (0.41, P = 0.026 and beans (0.45, P = 0.017 and were negatively significant for vitamin A (-0.63, P = 0.003, vitamin C (-0.42, P = 0.019 and yellow-green vegetables (-0.37, P = 0.046. For rectal cancer, the standardized partial correlation coefficient in fat (0.60, P = 0.002 was positively significant. Dietary fiber was not found to have a significant relationship with either colon or rectal cancers. Conclusions This study failed to show any protective effect of dietary fiber in subjects with a low fat intake (Japanese in this analysis, which supports Fuchs' findings in subjects with a high fat intake (US Americans.

Sugawara Kazuo

2001-10-01

83

Results of crack-arrest tests on irradiated a 508 class 3 steel  

International Nuclear Information System (INIS)

Ten crack-arrest toughness values for irradiated specimens of A 508 class 3 forging steel have been obtained. The tests were performed according to the American Society for Testing and Materials (ASTM) Standard Test Method for Determining Plane-Strain Crack-Arrest Fracture Toughness, Kla of Ferritic Steels, E 1221-88. None of these values are strictly valid in all five ASTM E 1221-88 validity criteria. However, they are useful when compared to unirradiated crack-arrest specimen toughness values since they show the small (averaging approximately 10 degrees C) shifts in the mean and lower-bound crack-arrest toughness curves. This confirms that a low copper content in ASTM A 508 class 3 forging material can be expected to result in small shifts of the transition toughness curve. The shifts due to neutron irradiation of the lower bound and mean toughness curves are approximately the same as the Charpy V-notch (CVN) 41-J temperature shift. The nine crack-arrest specimens were irradiated at temperatures varying from 243 to 280 degrees C, and to a fluence varying from 1.7 to 2.7 x 1019 neutrons/cm2 (> 1 MeV). The test results were normalized to reference values that correspond to those of CVN specimens irradiated at 284 degrees C to a fluence of 3.2 x 1019 neutrons/cm2 (> 1 MeV) in the same capsule as the crack-arrest specimens. This adjustment resulted in a shift to lower temperatures of all the data, and in particular moved two data points that appeared to lie close to or lower than the American Society of Mechanical Engineers Kla curve to positions that seemed more reasonable with respect to the remaining data. A special fixture was designed, fabricated, and successfully used in the testing. For reasons explained in the text, special blocks to receive the Oak Ridge National Laboratory clip gage were designed, and greater-than-standard crack-mouth opening displacements measured were accounted for. 24 refs., 13 figs., 12 tabs

84

Charpy impact test results on five materials and NIST verification specimens using instrumented 2-mm and 8-mm strikers  

International Nuclear Information System (INIS)

The Heavy-Section Steel Irradiation Program at Oak Ridge National Laboratory is involved in two cooperative projects, with international participants, both of which involve Charpy V-notch impact tests with instrumented strikers of 2mm and 8mm radii. Two heats of A 533 grade B class I pressure vessel steel and a low upper-shelf (LUS) submerged-arc (SA) weld were tested on the same Charpy machine, while one heat of a Russian Cr-Mo-V forging steel and a high upper-shelf (HUS) SA weld were tested on two different machines. The number of replicate tests at any one temperature ranged from 2 to 46 specimens. Prior to testing with each striker, verification specimens at the low, high, and super high energy levels from the National Institute of Standards and Technology (NIST) were tested. In the two series of verification tests, the tests with the 2mm striker met the requirements at the low and high energy levels but not at the super high energy. For one plate, the 2mm striker showed somewhat higher average absorbed energies than those for the 8-mm striker at all three test temperatures. For the second plate and the LUS weld, however, the 2mm striker showed somewhat lower energies at both test temperatures. For the Russian forging steel and the HUS weld, tests were conducted over a range of temperatures with tests at one laboratory using the 8mm striker and tests at a second laboratory using the 2mm striker. Lateral expansion was measured for all specimens and the results are compared with the absorbed energy results. The overall results showed generally good agreement (within one standard deviation) in energy measurements by the two strikers. Load-time traces from the instrumented strikers were also compared and used to estimate shear fracture percentage. Four different formulas from the European Structural Integrity Society draft standard for instrumented Charpy test are compared and a new formula is proposed for estimation of percent shear from the force-time trace

85

Charpy impact test results on five materials and NIST verification specimens using instrumented 2-mm and 8-mm strikers  

Energy Technology Data Exchange (ETDEWEB)

The Heavy-Section Steel Irradiation Program at Oak Ridge National Laboratory is involved in two cooperative projects, with international participants, both of which involve Charpy V-notch impact tests with instrumented strikers of 2mm and 8mm radii. Two heats of A 533 grade B class I pressure vessel steel and a low upper-shelf (LUS) submerged-arc (SA) weld were tested on the same Charpy machine, while one heat of a Russian Cr-Mo-V forging steel and a high upper-shelf (HUS) SA weld were tested on two different machines. The number of replicate tests at any one temperature ranged from 2 to 46 specimens. Prior to testing with each striker, verification specimens at the low, high, and super high energy levels from the National Institute of Standards and Technology (NIST) were tested. In the two series of verification tests, the tests with the 2mm striker met the requirements at the low and high energy levels but not at the super high energy. For one plate, the 2mm striker showed somewhat higher average absorbed energies than those for the 8-mm striker at all three test temperatures. For the second plate and the LUS weld, however, the 2mm striker showed somewhat lower energies at both test temperatures. For the Russian forging steel and the HUS weld, tests were conducted over a range of temperatures with tests at one laboratory using the 8mm striker and tests at a second laboratory using the 2mm striker. Lateral expansion was measured for all specimens and the results are compared with the absorbed energy results. The overall results showed generally good agreement (within one standard deviation) in energy measurements by the two strikers. Load-time traces from the instrumented strikers were also compared and used to estimate shear fracture percentage. Four different formulas from the European Structural Integrity Society draft standard for instrumented Charpy test are compared and a new formula is proposed for estimation of percent shear from the force-time trace.

Nanstad, R.K.; Sokolov, M.A.

1995-04-01

86

The S locus-linked Primula homeotic mutant sepaloid shows characteristics of a B-function mutant but does not result from mutation in a B-function gene.  

Science.gov (United States)

Floral homeotic and flower development mutants of Primula, including double, Hose in Hose, Jack in the Green and Split Perianth, have been cultivated since the late 1500s as ornamental plants but until recently have attracted limited scientific attention. Here we describe the characterization of a new mutant phenotype, sepaloid, that produces flowers comprising only sepals and carpels. The sepaloid mutation is recessive, and is linked to the S locus that controls floral heteromorphy. The phenotype shows developmental variability, with flowers containing three whorls of sepals surrounding fertile carpels, two whorls of sepals with a diminished third whorl of sepals surrounding a fourth whorl of carpels, or three whorls of sepals surrounding abnormal carpels. In some respects, these phenotypes resemble the Arabidopsis and Antirrhinum homeotic B-function mutants apetala3/deficiens (ap3/def) and pistillata/globosa (pi/glo). We have isolated the Primula vulgaris B-function genes PvDEFICIENS (PvDEF) and PvGLOBOSA (PvGLO), expression of both of which is affected in the sepaloid mutant. PvGLO, like sepaloid, is linked to the S locus, whereas PvDEF is not. However, our analyses reveal that sepaloid and PvGLO represent different genes. We conclude that SEPALOID is an S-linked independent regulator of floral organ identity genes including PvDEF and PvGLO. PMID:18564384

Li, Jinhong; Webster, Margaret; Dudas, Brigitta; Cook, Holly; Manfield, Iain; Davies, Brendan; Gilmartin, Philip M

2008-10-01

87

The "Life Potential": a new complex algorithm to assess "Heart Rate Variability" from Holter records for cognitive and diagnostic aims. Preliminary experimental results showing its dependence on age, gender and health conditions  

CERN Document Server

Although HRV (Heart Rate Variability) analyses have been carried out for several decades, several limiting factors still make these analyses useless from a clinical point of view. The present paper aims at overcoming some of these limits by introducing the "Life Potential" (BMP), a new mathematical algorithm which seems to exhibit surprising cognitive and predictive capabilities. BMP is defined as a linear combination of five HRV Non-Linear Variables, in turn derived from the thermodynamic formalism of chaotic dynamic systems. The paper presents experimental measurements of BMP (Average Values and Standard Deviations) derived from 1048 Holter tests, matched in age and gender, including a control group of 356 healthy subjects. The main results are: (a) BMP always decreases when the age increases, and its dependence on age and gender is well established; (b) the shape of the age dependence within "healthy people" is different from that found in the general group: this behavior provides evidence of possible illn...

Barra, Orazio A

2013-01-01

88

Alteraciones clínicas, humorales, laparoscópicas e hísticas hepáticas en donantes de sangre con anticuerpo al VHC positivo / Clinical, humoral, laparoscopic and hystic hepatic alterations in blood donors showing positive hepatitis virus C antibody test results  

Scientific Electronic Library Online (English)

Full Text Available SciELO Cuba | Language: Spanish Abstract in spanish Se realizó un estudio observacional descriptivo de 69 donantes de sangre, con anticuerpos al virus C positivo detectados en el Banco de Sangre Provincial, remitidos a la consulta provincial del Hospital Universitario Provincial "Vladimir Ilich Lenin", entre enero de 2000 a diciembre de 2006, y a qui [...] enes se le realizó biopsia hepática translaparoscópica. Con el objetivo de estimar las alteraciones clínicas, humorales, laparoscópicas e histopatológicas hepáticas se revisaron las boletas de solicitud de biopsia. Hubo predominio de las hepatitis crónicas con actividad mínima (12; 33,33 %) y ligera (13; 36,1 %). La mayoría de los pacientes estaban asintomáticos (62; 89,9 %, y con transaminasas normales (47; 68,1 %). La laparoscopia constituyó una prueba muy específica, con un 84,4 % de especificidad, con un considerable valor de una prueba positiva, 75 %, para el diagnóstico de la hepatitis crónica. Sin embargo, las bajas cifras de la sensibilidad (41 %) y del valor predictivo de una prueba negativa (57,1 %) para el diagnóstico de la hepatitis crónica, reafirman que la biopsia hepática sigue siendo la prueba de oro para el diagnóstico de esta enfermedad. Abstract in english An observational and descriptive study was made on 69 blood donors, who had positive C virus antibodies detected by the provincial blood bank and had been referred to "Vladimir Ilich Lenin" provincial university hospital from January 2000 to December 2006. They were performed translaparoscopic hepat [...] ic biopsy. For the purpose of estimating clinical, humoral, laparoscopic and histopathological hepatic disorders, the biopsy request forms were checked. Chronic hepatitis predominated, with minimal activity (12; 33.335) and slight activity (13; 36.1 %). Most of patients were asymptomatic (62; 89.9 %) and their transaminase values were normal (47; 68.1 %). Laparoscopy was a very specific test showing 84.4 % specificity, with a high value (75 %) in a positive test for chronic hepatitis diagnosis. However, low figures of sensitivity (41 %) and of the predictive value in a negative test (57.1 %) for chronic hepatitis diagnosis reaffirmed that hepatic biopsy continues to be the golden test for the diagnosis of this disease.

Agustín, Mulet Pérez; Évora, Arencibia Vidal; Martha, Gámez Escalona; Menelio, Pullés Labadié; Marlen, Pérez Lorenzo; Agustín, Mulet Gámez.

89

Applications of surveillance programme results to reactor pressure vessel integrity assessment. Results of a coordinated research project 2000-2004  

International Nuclear Information System (INIS)

This TECDOC has been developed under an IAEA Coordinated Research Project (CRP) on Surveillance Programme Results Application to Reactor Pressure Vessel Integrity Assessment. This CRP is the fifth in a series that have led to the defining of the most appropriate fracture toughness parameters (using relatively small test specimens) for ensuring structural integrity of reactor pressure vessel (RPV) materials. The CRP group consisted of 20 testing laboratories representing 15 Member States. The CRP had three main objectives: (1) to develop a large database of fracture toughness data using the Master Curve methodology for both precracked Charpy-sized specimens and one-inch thick (25.4 mm) compact tension (1T-CT) specimens, (2) to assess possible specimen bias effects and any effects of the range of temperatures used to determine T0, either using the single temperature or multi-temperature assessment methods, and (3) to develop international guidelines for measuring and applying Master Curve fracture toughness results for RPV integrity assessment. Fracture toughness test results showed clear evidence that lower values of unirradiated T0 were obtained using precracked Charpy specimens compared with results obtained from 1T-CT specimens. This bias in test results is very important when considering the use of precracked Charpy specimens for evaluating RPV integrity. In fact, this is a technical area where the results from this CRP were influential in changing the ASTM test method to include consideration of this effect. The direct measurement approach using the Master Curve approach for RPV structural integrity assessment has distinct advantages over the indirect methods used in the past for assessing radiation embrittlement effects. The Master Curve methodology already has been or is being assimilated into the ASME Boiler and Pressure Vessel Code, ASTM Standards, USNRC Regulations, German Regulations (KTA 3203), IAEA pressurized thermal shock guidelines for WWER reactors as well as the unified procedure for WWER component lifetime assessment and other industry guidance documents governing RPV integrity analysis. This report was written to allow nuclear utility engineers and industry scientists to directly measure fracture toughness using small surveillance size specimens of irradiated reactor pressure vessel steels and directly apply the results using the Master Curve approach for RPV structural integrity assessment. This report provides a summary of Master Curve fracture toughness test results on small surveillance type specimens of the IAEA Reference Material JRQ and other national steels from numerous laboratories throughout the world. In addition to transition temperature testing using Charpy V-notch test specimens, some emphasis was placed on using tensile and early-design fracture toughness test specimens applying elastic-plastic fracture mechanics methods. Further progress in the application of fracture mechanics analysis methods for radiation damage assessment was achieved in this phase. Improvement and unification of neutron dosimetry methods provided better data with less inherent scatter. All results together with their analyses and raw data were summarized in IAEA Technical Reports Series No. 265

90

What Do Blood Tests Show?  

Science.gov (United States)

... the NHLBI on Twitter. What Do Blood Tests Show? Blood tests show whether the levels of different substances in your ... for children. Complete Blood Count The table below shows some normal ranges for different parts of the ...

91

Numerical modelling of Charpy-V notch test by local approach to fracture. Application to an A508 steel in the ductile-brittle transition range; Modelisation de l'essai Charpy par l'approche locale de la rupture. Application au cas de l'acier 16MND5 dans le domaine de transition  

Energy Technology Data Exchange (ETDEWEB)

Ferritic steels present a transition of the rupture mode which goes progressively of a brittle rupture (cleavage) to a ductile rupture when the temperature increases. The following of the difference of the transition temperature of the PWR vessel steel by the establishment of toughness curves makes of the Charpy test an integrating part of the monitoring of the French PWR reactors. In spite of the advantages which are adapted to it in particular its cost, the Charpy test does not allow to obtain directly a variable which characterizes a crack propagation resistance as for instance the toughness used for qualifying the mechanical integrity of a structure. This work deals with the establishment of the through impact strength-toughness in the transition range of the vessel steel: 16MND5 from a non-empirical approach based on the local approach of the rupture. The brittle rupture is described by the Beremin model (1983), which allows to describe the dispersion inherent in this rupture mode. The description of the brittle fissure is carried out by the GTN model (1984) and by the Rousselier model (1986). This last model has been modified in order to obtain a realistic description of the brittle damage in the case of fast solicitations and of local heating. The method proposed to determine the parameters of the damage models depends only of tests on notched specimens and of the inclusion data of the material. The behaviour is described by an original formulation parametrized in temperature which allows to describe all the tests carried out in this study. Before using this methodology, an experimental study of the behaviour and of the rupture modes of the steel 16MND5 has been carried out. From the toughness tests carried out in quasi-static and dynamical conditions, it has been revealed that this steel does not present important unwedging of its toughness curve due to the velocity effect. In the transition range, local heating of about 150 C have been measured in the root of the notch as well as plastic deformations superior to 100%. After a fractography study allowing to identify the nature of the sites which lead to the cleavage initiation, the numerical study shows, particularly, the effect of the adiabatic heating and the taking into account of the growth of cavities around a second population of particles (carbides) on the ductile fissure. The application of the proposed methodology allows to describe the resilience data until middle energies of about 70 J. Beyond, an appearing weak dependency of the cleavage constraint with temperature has to be introduced. On the other hand, the evolving of the toughness can be described until middle values of 170 MPa/m without introducing dependency of the cleavage constraint with temperature. (O.M.)

Tanguy, B

2001-07-15

92

Application of boundary integral method to elastoplastic analysis of V-notched beams  

Science.gov (United States)

The boundary integral equation method was applied in the solution of the plane elastoplastic problems. The use of this method was illustrated by obtaining stress and strain distributions for a number of specimens with a single edge notch and subjected to pure bending. The boundary integral equation method reduced the nonhomogeneous biharmonic equation to two coupled Fredholm-type integral equations. These integral equations were replaced by a system of simultaneous algebraic equations and solved numerically in conjunction with the method of successive elastic solutions.

Rzasnicki, W.; Mendelson, A.

1975-01-01

93

Irradiation effects on fracture toughness of four nuclear reactor pressure vessel submerged-arc welds  

International Nuclear Information System (INIS)

This study applies statistical analyses to fracture toughness results for four irradiated 'current practice' submerged-arc welds and an A533 grade B class 1 plate. Charpy V-notch, tensile, and 25 mm thick compact specimens were irradiated at 2880C to neutron fluences of 0.7 to 2.0x1023 neutrons/m2 (> 1 MeV). The plate material contained 0.14% Cu and 0.67% Ni. The four submerged-arc welds contained 0.04 to 0.12% Cu and 0.10 to 0.63% Ni. The plate material showed a Charpy V-notch impact transition temperature increase of 680C, and a Charpy V-notch upper-shelf energy drop of 16%. The four submerged-arc welds showed smaller changes than the plate material did. The fracture toughness results from the 25 mm thick compact specimens showed approximately the same temperature shift as the Charpy V-notch results. The results imply that submerged-arc welds with both low-copper and low-nickel contents can exhibit essentially zero radiation embrittlement and that nickel can contribute to radiation embrittlement even when the copper content is low. (orig.)

94

Planning a Successful Tech Show  

Science.gov (United States)

Tech shows are a great way to introduce prospective students, parents, and local business and industry to a technology and engineering or career and technical education program. In addition to showcasing instructional programs, a tech show allows students to demonstrate their professionalism and skills, practice public presentations, and interact…

Nikirk, Martin

2011-01-01

95

Reality shows: uma abordagem psicossocial / Reality shows: a psychosocial approach  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese Desde os primórdios da civilização, o ser humano mostra necessidade de representar cenicamente seus dramas pessoais e vicissitudes existenciais. O "reality show" é uma das versões pós-modernas da encenação da vida humana. Este artigo, por meio de uma pesquisa bibliográfica, analisa criticamente as r [...] elações existentes entre o "reality show" e aspectos psicossociais do comportamento humano. Conclui-se que tais programas televisivos são o retrato da contemporaneidade, ou seja, revelam a morte do sujeito, a fugacidade das experiências vividas, a desvalorização da história e o culto à imagem e à superficialidade. Por meio da sedução do espectador, mobilizam-se aspectos primitivos de seu psiquismo, fazendo com que ele se sinta narcisicamente poderoso e onipotente e se acredite dono do destino dos participantes do programa. Sugerem-se novos estudos que contribuam para a reflexão crítica e maior conscientização. Abstract in english As from the earliest period of civilization, human beings have shown their need to perform their personal dramas and existential vicissitudes on stage. The reality show is one of the postmodern versions of human life staging. Based on a bibliographical research, this article analyzes on a critical b [...] asis the relations between the reality show and psychosocial aspects of human behavior. Such TV programs portray contemporaneous life, that is, they disclose the subject's death, the fugacity of life experiences, the history devaluation and the cult of image and superficiality. By seducing the spectator, the reality show mobilizes primitive aspects of the spectator's psychism, thereby making him feel narcissistically powerful and omnipotent, and able to decide the participants' fate. New studies that contribute to critical considerations and deeper consciousness would be advisable.

Marília Pereira Bueno, Millan.

96

Reality shows: uma abordagem psicossocial Reality shows: a psychosocial approach  

Directory of Open Access Journals (Sweden)

Full Text Available Desde os primórdios da civilização, o ser humano mostra necessidade de representar cenicamente seus dramas pessoais e vicissitudes existenciais. O "reality show" é uma das versões pós-modernas da encenação da vida humana. Este artigo, por meio de uma pesquisa bibliográfica, analisa criticamente as relações existentes entre o "reality show" e aspectos psicossociais do comportamento humano. Conclui-se que tais programas televisivos são o retrato da contemporaneidade, ou seja, revelam a morte do sujeito, a fugacidade das experiências vividas, a desvalorização da história e o culto à imagem e à superficialidade. Por meio da sedução do espectador, mobilizam-se aspectos primitivos de seu psiquismo, fazendo com que ele se sinta narcisicamente poderoso e onipotente e se acredite dono do destino dos participantes do programa. Sugerem-se novos estudos que contribuam para a reflexão crítica e maior conscientização.As from the earliest period of civilization, human beings have shown their need to perform their personal dramas and existential vicissitudes on stage. The reality show is one of the postmodern versions of human life staging. Based on a bibliographical research, this article analyzes on a critical basis the relations between the reality show and psychosocial aspects of human behavior. Such TV programs portray contemporaneous life, that is, they disclose the subject's death, the fugacity of life experiences, the history devaluation and the cult of image and superficiality. By seducing the spectator, the reality show mobilizes primitive aspects of the spectator's psychism, thereby making him feel narcissistically powerful and omnipotent, and able to decide the participants' fate. New studies that contribute to critical considerations and deeper consciousness would be advisable.

Marília Pereira Bueno Millan

2006-06-01

97

Using Graphs to Show Connections  

Science.gov (United States)

The purpose of this resource is to show how graphs of GLOBE data over time show the interconnectedness of Earth's system components at the local level. Students visit a study site, where they observe and recall their existing knowledge of air, water, soil, and living things to make a list of interconnections among the four Earth system components. They make predictions about the effects of a change in a system, inferring ways these changes affect the characteristics of other related components.

The GLOBE Program, University Corporation for Atmospheric Research (UCAR)

2003-08-01

98

Tokyo Motor Show 2003; Tokyo Motor Show 2003  

Energy Technology Data Exchange (ETDEWEB)

The text which follows present the different techniques exposed during the 37. Tokyo Motor Show. The report points out the great tendencies of developments of the Japanese automobile industry. The hybrid electric-powered vehicles or those equipped with fuel cells have been highlighted by the Japanese manufacturers which allow considerable budgets in the research of less polluting vehicles. The exposed models, although being all different according to the manufacturer, use always a hybrid system: fuel cell/battery. The manufacturers have stressed too on the intelligent systems for navigation and safety as well as on the design and comfort. (O.M.)

Joly, E.

2004-01-01

99

Magic Carpet Shows Its Colors  

Science.gov (United States)

The upper left image in this display is from the panoramic camera on the Mars Exploration Rover Spirit, showing the 'Magic Carpet' region near the rover at Gusev Crater, Mars, on Sol 7, the seventh martian day of its journey (Jan. 10, 2004). The lower image, also from the panoramic camera, is a monochrome (single filter) image of a rock in the 'Magic Carpet' area. Note that colored portions of the rock correlate with extracted spectra shown in the plot to the side. Four different types of materials are shown: the rock itself, the soil in front of the rock, some brighter soil on top of the rock, and some dust that has collected in small recesses on the rock face ('spots'). Each color on the spectra matches a line on the graph, showing how the panoramic camera's different colored filters are used to broadly assess the varying mineral compositions of martian rocks and soils.

2004-01-01

100

Rocks and Minerals Slide Show  

Science.gov (United States)

This interactive slide show of common rocks and minerals allows students to choose from two sets of minerals and click on a thumbnail to see a larger photograph with a full description of the mineral including color, streak, hardness, cleavage/fracture, and chemical composition. Also included are its use and where it is found. The rocks are divided into igneous, sedimentary, and metamorphic and can be accessed in the same manner. They are described on the basis of crystal size and mineral composition as well as use.

 
 
 
 
101

Evaluation technique of neutron-irradiation embrittlement in welded light water reactor pressure vessel steel  

International Nuclear Information System (INIS)

The ductile-brittle transition behavior of neutron-irradiated welded A533B Cl.1 pressure vessel steel has been investigated by means of small specimen test technique. Current surveillance test method is discussed on the basis of the obtained results. The submerged arc welded thick plate for plant-use was fabricated. Standard size, one-third size and 1.5 mm size Charpy V-notch specimens were prepared by changing the distance from the fusion boundary, so that a V-notch was located in the position to be evaluated. Neutron irradiations were performed in JMTR with fluence of 0.75 and 1.3 x 1024 n/m2(E >1 MeV). In both the cases before and after the irradiations, ductile-brittle transition temperature (DBTT) is lower and the upper-shelf energy(USE) is higher for so-called HAZ(M1) specimen, which has a V-notch 1 mm away from the fusion boundary, than base metal and weld metal. However, it is revealed that DBTT of the HAZ(M4) specimen with a V-notch 4 mm away from the boundary is higher than that of base metal. Hence the HAZ(M4) specimen shows rather higher DBTT, that is, lower toughness. Surveillance of HAZ specimen is potentially important and should not be omitted in case that impact property of HAZ cannot be represented by base metal. (author)

102

Biomass route shows lower cost  

Energy Technology Data Exchange (ETDEWEB)

There has been much discussion concerning the economics of using biomass for the production of substitute fuels and it has been argued that the net energy gain could be small or even negative. The development of the ATPAL process is described and it is claimed that only one quarter of the energy equivalent contained in the alcohol will be consumed in the total process. Both the pilot plant and a commercial scale plant with some modifications are described. The most significant advantage claimed for the ATPAL process is in its low process energy savings resulting from mechanical vapour recompression, recycling the heat and production of a low volume of effluent.

Taffe, P.

1980-11-21

103

Casimir experiments showing saturation effects  

International Nuclear Information System (INIS)

We address several different Casimir experiments where theory and experiment disagree. First out is the classical Casimir force measurement between two metal half spaces; here both in the form of the torsion pendulum experiment by Lamoreaux and in the form of the Casimir pressure measurement between a gold sphere and a gold plate as performed by Decca et al.; theory predicts a large negative thermal correction, absent in the high precision experiments. The third experiment is the measurement of the Casimir force between a metal plate and a laser irradiated semiconductor membrane as performed by Chen et al.; the change in force with laser intensity is larger than predicted by theory. The fourth experiment is the measurement of the Casimir force between an atom and a wall in the form of the measurement by Obrecht et al. of the change in oscillation frequency of a 87Rb Bose-Einstein condensate trapped to a fused silica wall; the change is smaller than predicted by theory. We show that saturation effects can explain the discrepancies between theory and experiment observed in all these cases.

104

Casimir experiments showing saturation effects  

CERN Document Server

We address several different Casimir experiments where theory and experiment disagree. First out is the classical Casimir force measurement between two metal half spaces; here both in the form of the torsion pendulum experiment by Lamoreaux and in the form of the Casimir pressure measurement between a gold sphere and a gold plate as performed by Decca et al.; theory predicts a large negative thermal correction, absent in the high precision experiments. The third experiment is the measurement of the Casimir force between a metal plate and a laser irradiated semiconductor membrane as performed by Chen et al.; the change in force with laser intensity is larger than predicted by theory. The fourth experiment is the measurement of the Casimir force between an atom and a wall in the form of the measurement by Obrecht et al. of the change in oscillation frequency of a 87 Rb Bose-Einstein condensate trapped to a fused silica wall; the change is smaller than predicted by theory. We show that saturation effects can exp...

Sernelius, Bo E

2009-01-01

105

Results of examinations of pressure vessel samples and instrument nozzles from the TMI-2 lower head  

International Nuclear Information System (INIS)

Fifteen prism-shaped steel samples were removed from the lower head of the damaged TMI-2 reactor pressure vessel to assess the effects of approximately 19 metric tons of molten core debris that had relocated there during the 1979 loss-of-coolant accident. Metallographic examinations of the samples revealed that inside surface temperatures of 800 to 1,100 degree C were attained during the accident in an elliptical shaped ''hot spot'' ?1 x 0.7 m. Tensile, creep, and Charpy V-notch specimens were also cut from the samples to assess the mechanical properties of the lower head material at temperatures up to the peak accident temperature. These properties were used in a margin to failure analysis of the lower head. Examinations of instrument nozzles removed from the lower head region assisted in defining the relocation scenario of the molten core debris and showed that the lower head was largely protected from catastrophic failure by a solidified layer around the molten core debris that acted as a partial thermal insulator

106

Show Versus No Show: A Comparison of Referral Calls to a Suicide Prevention and Crisis Service  

Science.gov (United States)

This study involves an exploratory content analysis of taped telephone calls to a suicide prevention and crisis service. The aim of the research was to discover variables that might differentiate between referrals resulting in show'' and those resulting in no show''. The relationship between this research and a crisis intervention model is…

Slaikeu, Karl; Lester, David

1973-01-01

107

The Physics of Equestrian Show Jumping  

Science.gov (United States)

This article discusses the kinematics and dynamics of equestrian show jumping. For some time I have attended a series of show jumping events at Spruce Meadows, an international equestrian center near Calgary, Alberta, often referred to as the "Wimbledon of equestrian jumping." I have always had a desire to write an article such as this one, but when I searched the Internet for information and looked at YouTube presentations, I could only find simplistic references to Newton's laws and the conservation of mechanical energy principle. Nowhere could I find detailed calculations. On the other hand, there were several biomechanical articles with empirical reports of the results of kinetic and dynamic investigations of show jumping using high-speed digital cameras and force plates. They summarize their results in tables that give information about the motion of a horse jumping over high fences (1.40 m) and the magnitudes of the forces encountered when landing. However, they do not describe the physics of these results.

Stinner, Art

2014-04-01

108

Trematode hemoglobins show exceptionally high oxygen affinity.  

Science.gov (United States)

Ligand binding studies were made with hemoglobin (Hb) isolated from trematode species Gastrothylax crumenifer (Gc), Paramphistomum epiclitum (Pe), Explanatum explanatum (Ee), parasitic worms of water buffalo Bubalus bubalis, and Isoparorchis hypselobagri (Ih) parasitic in the catfish Wallago attu. The kinetics of oxygen and carbon monoxide binding show very fast association rates. Whereas oxygen can be displaced on a millisecond time scale from human Hb at 25 degrees C, the dissociation of oxygen from trematode Hb may require a few seconds to over 20 s (for Hb Pe). Carbon monoxide dissociation is faster, however, than for other monomeric hemoglobins or myoglobins. Trematode hemoglobins also show a reduced rate of autoxidation; the oxy form is not readily oxidized by potassium ferricyanide, indicating that only the deoxy form reacts rapidly with this oxidizing agent. Unlike most vertebrate Hbs, the trematodes have a tyrosine residue at position E7 instead of the usual distal histidine. As for Hb Ascaris, which also displays a high oxygen affinity, the trematodes have a tyrosine in position B10; two H-bonds to the oxygen molecule are thought to be responsible for the very high oxygen affinity. The trematode hemoglobins display a combination of high association rates and very low dissociation rates, resulting in some of the highest oxygen affinities ever observed. PMID:9675199

Kiger, L; Rashid, A K; Griffon, N; Haque, M; Moens, L; Gibson, Q H; Poyart, C; Marden, M C

1998-01-01

109

Reevaluation of irradiation embrittlement of surveillance specimens  

International Nuclear Information System (INIS)

The results of surveillance specimen programmes for VVER-440/V-213C type reactors are summarized. A comparison is given of the transition temperature shifts induced by irradiation and derived from impact Charpy V-notch toughness as well as from static fracture toughness tests on pre-cracked Charpy size specimens (COD). Two methods were used to determine the static fracture toughness shifts: standard COD type specimens from the standard surveillance programmes, and reconstituted COD type specimens from broken halves of Charpy V-notch specimens, whereby identical irradiation conditions were assured. The results show that the transition temperature shifts from static tests are generally larger than those from dynamic tests. (P.A.)

110

Investigation on the impact strength and toughness of A533 Grade B composition weld metal using small specimens  

International Nuclear Information System (INIS)

An investigation was carried out to determine the impact strength and the fracture toughness of the multipass submerged arc (SA) weld metal of A533 grade B (20MnMoNi55) composition using Charpy V-notch and precracked Charpy-type specimens. The experimental results show that there is no large difference between the micro-hardness measured in the primary and secondary zones of the SA weld metal. The Charpy V-notch impact and fracture mechanics tests yield similar results in the primary and secondary zones. Nearly all specimens investigated exhibit the phenomenon of crack jump (pop-in of the load), that is, sudden cleavage or quasicleavage often followed by arrest of the crack

111

A study of the fracture process and factors that control toughness variability in Charpy V-notch specimens  

Science.gov (United States)

La presente etude a ete initiee pour developper une comprehension quantitative du processus de rupture avec les facteurs qui controlent la dispersion des mesures de tenacite lorsque des eprouvettes Charpy entaillees en V sont utilisees. Un grand nombre d'essais ont ete realises pour un acier C-Mn: eprouvettes Charpy testees sous impact, eprouvettes Charpy testees en flexion lente, eprouvettes axisymetriques entaillees et sollicitees en traction et essais de tenacite sur eprouvettes prefissurees. Base sur le concept de la statistique de Weibull, l'approche locale developpee par le groupe Beremin a ete utilisee pour decrire la probabilite de rupture par clivage en fonction de la contrainte appliquee aussi bien qu'en fonction de l'energie Charpy obtenue. Le calcul par elements finis a ete realise pour determiner la distribution de la deformation et des contraintes en pointe d'entaille et de fissure. La nouvelle approche introduite decrit bien les resultats experimentaux. Les points d'initiation du clivage ont ete identifies au MEB et par la suite, avec la technique de faisceau d'ions focalise, sectionnes, polis et examines. L'examen de la microstructure sous le point d'initiation revele clairement que le clivage s'initie par un mecanisme d'empilement de dislocations ou les dislocations sont arretees aux joints de grain, aux interfaces de perlite/ferrite ou de perlite qui agissent comme barrieres physiques.

Bouchard, Real

112

Resultados histológicos e detecção do HPV em mulheres com células escamosas atípicas de significado indeterminado e lesão escamosa intra-epitelial de baixo grau na colpocitologia oncológica / Histological results and HPV detection in women with pap smear showing atypical squamous cells of undetermined significance and low-grade squamous intraepithelial lesion  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese OBJETIVOS: avaliar o desempenho da colpocitologia oncológica (CO) e da Captura de Híbridos II (CHII) para o diagnóstico de lesão cervical histológica significativa (NIC2/3) em mulheres encaminhadas com CO contendo atipias celulares de significado indeterminado (ASCUS) ou lesão escamosa intra-epiteli [...] al de baixo grau (LSIL). MÉTODOS: estudo de corte transversal no qual foram incluídas 161 mulheres encaminhadas, entre agosto de 2000 e setembro de 2002, devido a CO com resultado de ASCUS ou LSIL. As mulheres responderam a questionário específico sobre características sociodemográficas e reprodutivas e foram submetidas a exame ginecológico com coleta de CO e CHII, sendo realizada colposcopia com eventual biópsia de áreas suspeitas. Foi aplicado o teste do qui-quadrado para as associações da idade, uso de condom, uso de anticoncepcional oral e tabagismo com os resultados da CHII. Foram calculados a sensibilidade, especificidade, valor preditivo positivo e valor preditivo negativo da CO e da CHII para detectar NIC2/3. Todos os cálculos foram realizados com intervalos de confiança estatística de 95%. RESULTADOS: sessenta e sete porcento das mulheres com menos de 30 anos de idade tiveram testes positivos para o HPV. A CO e CHII tiveram sensibilidade de 82% em detectar NIC2/3 quando considerados como positivos ASCUS, LSIL ou HSIL. Quando se consideram como positivas apenas as CO com HSIL, este exame apresenta acentuado ganho de especificidade (de 29 para 95%) e valor preditivo positivo (de 12 para 50%), superando a CHII, porém com redução igualmente significativa de sua sensibilidade (de 82 para 41%). CONCLUSÕES: nossos resultados indicaram grande potencial da CHII para detectar mulheres com NIC2/3 entre as pacientes com ASCUS/LSIL na CO de encaminhamento. Abstract in english OBJECTIVE: to assess the ability of Pap smear and hybrid capture II (HCII) to detect clinically significant cervical lesions (CIN2/3) in women referred to hospital due to atypical squamous cells of unknown significance (ASCUS) or low-grade squamous intraepithelial lesions (LSIL). METHODS: a cross-se [...] ctional study comprising 161 women referred to the Taubaté University Hospital due to ASCUS/LSIL, between August 2000 and September 2002. All women responded to a questionnaire regarding sociodemographic and reproductive characteristics and were subjected to gynecological examination with specimen collection for Pap test and HCII, along with colposcopy and eventual cervical biopsy. The relationship between HCII results and age, use of condom, oral hormonal contraception, and smoking were evaluated by the chi-square test. The sensitivity, specificity, positive and negative predictive values of both Pap test and HCII were calculated. All calculations were performed within 95% confidence intervals. RESULTS: sixty-seven percent of the women that tested positive for HPV were less than 30 years old. Pap smear and HCII showed the same 82% sensitivity in detecting CIN2/3 when the threshold for a positive Pap result was ASCUS, LSIL or HSIL. Pap smear specificity and positive predictive values were substantially increased when only HSIL results were considered as positive (from 29 to 95% and 12 to 50%, respectively). These figures were superior to those of HCII, but at the expense of an expressive loss of sensitivity (from 82% to 41%). CONCLUSIONS: our results substantiate the potential of HCII in detecting CIN2/3 among women referred due to ASCUS/LSIL.

André Luis Ferreira, Santos; Sophie Françoise Mauricette, Derchain; Luis Otávio, Sarian; Elizabete Aparecida, Campos; Marcos Roberto dos, Santos; Gislaine Aparecida, Fonsechi-Carvasan.

113

The Wonders of Physics Traveling Show  

Science.gov (United States)

The Wonders of Physics is a live physics show designed to stimulate interest in science in people of all ages and backgrounds. The program's fast-paced presentation is supplemented by a variety of media tools. In addition, a smaller traveling show is based in Madison, WI, but does shows all over the United States and Canada.

Physics, The W.

2004-06-02

114

A new experimental method on brittle fracture propagation arrest characteristics of welded steel plate  

International Nuclear Information System (INIS)

The usual ESSO test has not been successful for the propagation arrest test of the welded part. The paper shows a new type specimen which is a modification of the usual ESSO specimen with regard to notch geometry. It is machined with a chevron notch instead of a usual straight on. The brittle crack that starts from the chevron notch goes along the weld bead because of higher mechanical constraint near the notch root. Three kinds of steels were here used and welded by three kinds of welding methods: manual welding, submerged arc welding, and electro-gas welding. In order to search the correlation between Charpy impact test results and fracture toughness, Charpy tests by 2 mm V-notch and chevron notch were conducted. The transition temperature of chevron notch is higher that that of 2 mm V-notch because of higher mechanical constraint. The conclusions are discussed. (Auth.)

115

Solar System Odyssey - Fulldome Digital Planetarium Show  

Science.gov (United States)

This is a Fulldome Digital Planetarium Show. Learners go on a futuristic journey through our Solar System. They explore the inner and outer planets, then the moons: Titan, Europa, and Callisto as possible places to establish a human colony. A full-length preview of the show is available on the website, you need to scroll down about 3/4 of the page - under section on children's shows, direct link not available.

116

Acculturation, Cultivation, and Daytime TV Talk Shows.  

Science.gov (United States)

Explores the cultivation phenomenon among international college students in the United States by examining the connection between levels of acculturation, daytime TV talk show viewing, and beliefs about social reality. Finds that students who scored low on acculturation and watched a great deal of daytime talk shows had a more negative perception…

Woo, Hyung-Jin; Dominick, Joseph R.

2003-01-01

117

International Plowing Match & Farm Machinery Show  

Science.gov (United States)

The 1995 International Plowing Match & Farm Machinery Show in Ontario, Canada has a site of the Web. The IPM is a non-profit organization of volunteers which annually organizes Canada's largest farm machinery show. The event is commercial and educational. Thousands of school children and educators attend and participate in organized educational activities.

1995-01-01

118

The Physics of Equestrian Show Jumping  

Science.gov (United States)

This article discusses the kinematics and dynamics of equestrian show jumping. For some time I have attended a series of show jumping events at Spruce Meadows, an international equestrian center near Calgary, Alberta, often referred to as the "Wimbledon of equestrian jumping." I have always had a desire to write an article such as this…

Stinner, Art

2014-01-01

119

Small punch test evaluation of intergranular embrittlement of an alloy steel  

International Nuclear Information System (INIS)

The ductile-brittle transition temperature in steel is commonly determined using Charpy V-notch impact specimens as specified by ASTM E23-81. In some specific cases, however, the use of this standardized test specimen may be impractical, if not impossible. For instance, it is well known that ferritic steels show a substantial degradation of the mechanical properties after long time exposure to an irradiation environment. Because of the increase in strength and the reduction in ductility due to neutron irradiation, the Charpy V-notch transition temperature is raised causing concern from a safety point of view. To study these radiation effects, a test specimen much smaller than the standard Charpy V-notch specimen would be extremely desirable for two reasons. First, to study neutron damage small specimens take less space within a reactor. Secondly, the damage achieved in simulation experiments, such as proton or electron accelerators, is limited to small penetration depths. Several efforts on the development of such a small test specimen, similar to that used to determine the ductility of sheet metal, as recommended by ASTM E643-78, have been described in the literature. The paper reports on correlations between small punch (SP) and Charpy V-notch (CVN) test results obtained on temper-embrittled NiCr steel. The ductile-brittle transition temperature (DBTT) with intergranular embrittlement being induced by grain boundary segregation of specific impurities was determined. The relation between test results discussed in terms of the micromechanisms of intergranular cracking. It is suggested that in radiation embrittlement investigations similar correlations may be obtained

120

2008 LHC Open Days Physics: the show  

CERN Document Server

A host of events and activities await visitors to the LHC Open Days on 5 and 6 April. A highlight will be the physics shows funded by the European Physical Society (EPS), which are set to surprise and challenge children and adults alike! School children use their experience of riding a bicycle to understand how planets move around the sun (Copyright : Circus Naturally) Participating in the Circus Naturally show could leave a strange taste in your mouth! (Copyright : Circus Naturally) The Rino Foundation’s experiments with liquid nitrogen can be pretty exciting! (Copyright: The Rino Foundation)What does a bicycle have in common with the solar system? Have you ever tried to weigh air or visualise sound? Ever heard of a vacuum bazooka? If you want to discover the answers to these questions and more then come to the Physics Shows taking place at the CERN O...

2008-01-01

 
 
 
 
121

Data shows treatment inequalities for EU'  

...Data shows treatment inequalities for EU's multiple sclerosis patients | EurActiv The MS Barometer 2011, which has measured and compared wellbeing and quality ...of life for people living with multiple sclerosis in 33 European countries, including 26 EU member states, shows huge disparities in terms ... specialreport-brain-multiple-sclerosis,brain research,Multiple Sclerosis EU news & policy debates- across languages - en Click here for EU news »x ...Special Reports Enabling the Next Technology Revolution Industrial Renaissance The Brain and Multiple Sclerosis Quo Vadis Health and Safety at Work? Sustainable and ...

122

Show me the MUN-y  

Digital Repository Infrastructure Vision for European Research (DRIVER)

The structure of the MUN domain of the synaptic protein Munc13-1 by Li, et al., in this issue of Structure (Li et al., 2011) shows that seemingly disparate regulators of SNARE-mediated membrane fusion are highly conserved at the structural level.

Munson, Mary

2011-01-01

123

Show me the MUN-y  

Science.gov (United States)

The structure of the MUN domain of the synaptic protein Munc13-1 by Li, et al., in this issue of Structure (Li et al., 2011) shows that seemingly disparate regulators of SNARE-mediated membrane fusion are highly conserved at the structural level. PMID:22000505

Munson, Mary

2011-01-01

124

Show Them You Really Want the Job  

Science.gov (United States)

Showing that one really "wants" the job entails more than just really wanting the job. An interview is part Broadway casting call, part intellectual dating game, part personality test, and part, well, job interview. When there are 300 applicants for a position, many of them will "fit" the required (and even the preferred) skills listed in the job…

Perlmutter, David D.

2012-01-01

125

Development, management and economy of show caves.  

Directory of Open Access Journals (Sweden)

Full Text Available The problems concerning the development of show caves are here considered by taking into account different aspects of the problem. A procedure to carry out an Environmental Impact Assessment (EIA has been established in the last decade and it is now currently applied. Such an assessment starts with a pre-operational phase to obtain sufficient information on the undisturbed status of a cave to be developed into a show cave. Successively a programme for its development is established with the scope to optimise the intervention on the cave at the condition that its basic environmental parameters are not irreversibly modified. The last phase of the assessment is focussed to assure a feedback through a monitoring network in order to detect any unforeseen difference or anomaly between the project and the effective situation achieved after the cave development. Some data on some of the most important show caves in the world are reported and a tentative evaluation of the economy in connection with the show caves business is eventually made.

Cigna Arrigo A.

2000-01-01

126

Show and Tell : Performanceaften på Charlottenborg  

DEFF Research Database (Denmark)

Fredag d. 1 november blev Kunsthal Charlottenborg indtaget af performanceprogrammet Show & Tell med et bredspektret program af danske og internationale kunstnere indenfor performance-, lyd- og installationskunst. Programmet præsenterer værker, der undersøger kroppens stadig mere symbiotiske forhold til maskinen, en lecture-performance i grænselandet mellem historiefortælling, poesi og vidensformidling. En undersøgelse af indeksikalitet og iSociety, en arkitektonisk lytteoplevelse, et lydkunstværk genereret af publikum og et requiem ud over det sædvanlige. Værkerne bliver udført af Olof Olsson (S/DK), Pernille With Madsen, Emil Alenius, Andrés Galeano (E/DE), Kasper Vang & Mads Forsby, Nanna Lysholt Hansen og Molly & Me (Molly Haslund & Catherine Hoffmann (UK)) Kurateret af Judith Schwarzbart og Sanne Krogh Groth Produceret af studerende ved Performance-design Programmet var støttet af Statens Kunstråd og studienævnet på Performance-design. Show & Tell - Performance program: kl. 16.30-19 Adresse: Kunsthal Charlottenborg, Nyhavn 2, 1051 København K

127

Latest European coelacanth shows Gondwanan affinities  

Digital Repository Infrastructure Vision for European Research (DRIVER)

The last European fossil occurrence of a coelacanth is from the Mid-Cretaceous of the English Chalk (Turonian, 90 million years ago). Here, we report the discovery of a coelacanth from Late Cretaceous non-marine rocks in southern France. It consists of a left angular bone showing structures that imply close phylogenetic affinities with some extinct Mawsoniidae. The closest relatives are otherwise known from Cretaceous continental deposits of southern continents and suggest that the dispersal ...

Cavin, Lionel; Forey, Peter L.; Buffetaut, Eric; Tong, Haiyan

2005-01-01

128

Trematode hemoglobins show exceptionally high oxygen affinity.  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Ligand binding studies were made with hemoglobin (Hb) isolated from trematode species Gastrothylax crumenifer (Gc), Paramphistomum epiclitum (Pe), Explanatum explanatum (Ee), parasitic worms of water buffalo Bubalus bubalis, and Isoparorchis hypselobagri (Ih) parasitic in the catfish Wallago attu. The kinetics of oxygen and carbon monoxide binding show very fast association rates. Whereas oxygen can be displaced on a millisecond time scale from human Hb at 25 degrees C, the dissociation of ox...

Kiger, L.; Rashid, A. K.; Griffon, N.; Haque, M.; Moens, L.; Gibson, Q. H.; Poyart, C.; Marden, M. C.

1998-01-01

129

Show Me the Invisible: Visualizing Hidden Content  

Science.gov (United States)

Content on computer screens is often inaccessible to users because it is hidden, e.g., occluded by other windows, outside the viewport, or overlooked. In search tasks, the efficient retrieval of sought content is important. Current software, however, only provides limited support to visualize hidden occurrences and rarely supports search synchronization crossing application boundaries. To remedy this situation, we introduce two novel visualization methods to guide users to hidden content. Our first method generates awareness for occluded or out-of-viewport content using see-through visualization. For content that is either outside the screen’s viewport or for data sources not opened at all, our second method shows off-screen indicators and an on-demand smart preview. To reduce the chances of overlooking content, we use visual links, i.e., visible edges, to connect the visible content or the visible representations of the hidden content. We show the validity of our methods in a user study, which demonstrates that our technique enables a faster localization of hidden content compared to traditional search functionality and thereby assists users in information retrieval tasks.

Geymayer, Thomas; Steinberger, Markus; Lex, Alexander; Streit, Marc; Schmalstieg, Dieter

2014-01-01

130

EXPERT SYSTEMS SHOW PROMISE FOR CUSTOMER INQUIRIES  

Science.gov (United States)

This article describes results of an agreement between the North Penn Water Authority in Lansdale, Pa., and the US Environmental Protection Agency, Drinking Water Research Division, Cincinnati, Ohio, to study use of expert systems technology in a water utility. The threeyear stud...

131

Microbiological and environmental issues in show caves.  

Science.gov (United States)

Cultural tourism expanded in the last half of the twentieth century, and the interest of visitors has come to include caves containing archaeological remains. Some show caves attracted mass tourism, and economical interests prevailed over conservation, which led to a deterioration of the subterranean environment and the rock art. The presence and the role of microorganisms in caves is a topic that is often ignored in cave management. Knowledge of the colonisation patterns, the dispersion mechanisms, and the effect on human health and, when present, over rock art paintings of these microorganisms is of the utmost importance. In this review the most recent advances in the study of microorganisms in caves are presented, together with the environmental implications of the findings. PMID:22806150

Saiz-Jimenez, Cesareo

2012-07-01

132

ArtBots: The Robot Talent Show  

Science.gov (United States)

Sponsored by the Columbia University Computer Music Center and the Digital Media Center of Columbia University's School of the Arts, ArtBots is "an international art exhibition for robotic art and art-making robots." The annual event invites artists from around the world to enter their robots based on the broad guidelines: "if you think it's a robot and you think it's art, we encourage you to submit." The Participants section includes a photo, description (including some interpretive analysis) and website link for each of the ArtBot 2004 participants. Some sample entries include a robot that draws, one that picks up balls and a "robotic sculpture built around a section of tree trunk." The website even offers a sample of the Theme Song from the show.

133

ODSCC algorithm shows correlation with degradation  

Energy Technology Data Exchange (ETDEWEB)

Over the last few years we have attempted to develop an algorithm to evaluate the impact of secondary water chemistry on tube degradation in PWR steam generators. Effects of individual factors were assessed and then consolidated to form an algorithm for ODSCC propensity. The algorithm utilizes secondary water chemistry data to calculate ODSCC propensity as a variable named Mega PHI. Prior attempts to correlatealgorithm calculations with actual degradation in operating steam generators have resulted in very disappointing results. Recent modifications to the algorithm have demonstrated improved correlation between Mega PHI (calculated result from the algorithm) and actual degradation history from operating plants. The recent modifications involve the inclusion of the synergistic effect of boric acid application of secondary water and of high silica concentration in steam generator toward inhibiting ODSCC. Data from several plants with mill annealed alloy 600 tubing in the steam generators and operating with the primary coolant inlet temperature in the range of 608 to 624 degrees F (320 to 329 degrees C) were evaluated and the results compared with actual degradation reported from in-service inspections. The population of plants includes those with very few tubes repaired and those with hundreds of tubes repaired due to ODSCC at tube support plates. The observation of substantial correlation between the algorithm calculation and actual degradation signifies the roles of boric acid and silica in inhibiting ODSCC. It is recommended that further evaluation of the role of these chemical species be performed using more extensive data. The goal is to modify secondary water chemistry guidelines with the ultimate aim of minimizing corrosion of steam generator tubes. (author)

Prabhu, P.J.; Rootham, M.W.; Zupetic, N.L. [Westinghouse Electric Co., Madison, PA (United States)

1998-07-01

134

ODSCC algorithm shows correlation with degradation  

International Nuclear Information System (INIS)

Over the last few years we have attempted to develop an algorithm to evaluate the impact of secondary water chemistry on tube degradation in PWR steam generators. Effects of individual factors were assessed and then consolidated to form an algorithm for ODSCC propensity. The algorithm utilizes secondary water chemistry data to calculate ODSCC propensity as a variable named Mega PHI. Prior attempts to correlate algorithm calculations with actual degradation in operating steam generators have resulted in very disappointing results. Recent modifications to the algorithm have demonstrated improved correlation between Mega PHI (calculated result from the algorithm) and actual degradation history from operating plants. The recent modifications involve the inclusion of the synergistic effect of boric acid application of secondary water and of high silica concentration in steam generator toward inhibiting ODSCC. Data from several plants with mill annealed alloy 600 tubing in the steam generators and operating with the primary coolant inlet temperature in the range of 608 to 624 degrees F (320 to 329 degrees C) were evaluated and the results compared with actual degradation reported from in-service inspections. The population of plants includes those with very few tubes repaired and those with hundreds of tubes repaired due to ODSCC at tube support plates. The observation of substantial correlation between the algorithm calculation and actual degradation signifies the roles of boric acid and silica in inhibiting ODSCC. It is recommended that further evaluation of the role of these chemical species be performed using more extensive data. The goal is to modify secondary water chemistry guidelines with the ultimate aim of minimizing corrosion of steam generator tubes. (author)

135

The Source of Lake Wobegon (slide show  

Directory of Open Access Journals (Sweden)

Full Text Available John J. Cannell's late 1980's "Lake Wobegon" reports suggested widespread deliberate educator manipulation of norm-referenced standardized test (NRT administrations and results, resulting in artificial test score gains. The Cannell studies have been referenced in education research since, but as evidence that high stakes (and not cheating or lax security cause test score inflation. This article examines that research and Cannell's data for evidence that high stakes cause test score inflation. No such evidence is found. Indeed, the evidence indicates that, if anything, the absence of high stakes is associated with artificial test score gains. The variable most highly correlated with test score inflation is general performance on achievement tests, with traditionally low-performing states exhibiting more test score inflation on low-stakes norm-referenced tests than traditionally high-performing states, regardless of whether or not a state also maintains a high-stakes testing program. The unsupported high-stakes-cause-test-score-inflation hypothesis seems to derive from the surreptitious substitution of an antiquated definition of the term "high stakes" and a few studies afflicted with left-out-variable bias. The source of test-score inflation is lax security, regardless the stakes of a test.

Richard P. Phelps

2007-05-01

136

Do Education Organizations Show Learning Organizations Charecterics?  

Directory of Open Access Journals (Sweden)

Full Text Available Learning, an important element in terms of affecting the change of individual, organizational and social structures, will occur more effectively when the institutions in social structure turn into learning organizations. Senge (1993 concept of learning organization, constantly changing, evolving and renewing itself described as a dynamic structure. This concept has an important place in all institutions is also a separate meaning for educational institutions. In this context, schools training the human resources, appropriate for the aim of being information society, as individuals have taken continuous learning as their principles, teachers providing educational and supporting services and their perceptions of learning organization are of the great importance. In Bal?kesir, the study was conducted virtue of this importance has been serving the state and private institutions serving 848 elementary teachers, perceptions of the learning organization and organizational barriers that prevent it is to be determined through a comparative analysis. As a result of the survey, in the framework of the bases in literature, it has been found out that the state primary schools don’t have the features of learning organization, contrary to the private primary schools.

Sedat Yumusak,

137

Transition temperature tests show fracture behavior  

International Nuclear Information System (INIS)

The objective of the research reported in this article was to examine the predictability of full-scale fracture behavior through the use of the fullthickness drop weight tear tests (DWTT) currently employed to specify high toughness, high-strength, lowalloy (HSLA) line pipe. The DWT tests studied are the standard pressed notch DWTT as specified by the American Petroleum Institute (DWTT-API), a recently developed precracked DWTT (DWTT-PC), and fatigue cracked DWTT (DWTTFC). The study was conducted at the brittle-ductile transition temperatures of the pipe steels to see which DWT test specimen most accurately defines the full-scale transition temperature. The main parameter of comparison between the full-scale tests and the DWT tests is the percent shear area appearance of the fractured surface. For normalized steels and smaller wall thickness, earlier investigations have shown that a good correlation exists between results of such fullscale tests and DWT-API tests. However, it must be verified that this correlation is also valid for modern HSLA steels and heavy wall thickness. From 17 pipes, 14 were produced from thermomechanically treated materials, and 3 were quenched and tempered

138

Do Tantalum and Titanium Cups Show Similar Results in Revision Hip Arthroplasty?  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Porous surfaces are intended to enhance osteointegration of cementless implants. Tantalum has been introduced in an effort to enhance osseointegration potential of uncemented components. We therefore compared the clinical outcome of acetabular components with two different porous surfaces. We retrospectively reviewed 283 patients (295 hips) who underwent cementless revision hip arthroplasty with either an HA-coated titanium cup (207 patients, 214 hips) or porous tantalum cup (79 patients, 81 ...

Jafari, S. Mehdi; Bender, Benjamin; Coyle, Catelyn; Parvizi, Javad; Sharkey, Peter F.; Hozack, William J.

2010-01-01

139

Cassini UVIS Observations Show Active Saturn's Rings  

Science.gov (United States)

The Cassini Ultraviolet Imaging Spectrograph (UVIS) is part of the remote sensing payload of the NASA/ESA Cassini spacecraft. This spectrograph includes channels for extreme UV and far UV spectroscopic imaging, high speed photometry of stellar occultations, solar EUV occultation, and a hydrogen/deuterium absorption cell. We report our initial results from UVIS observations of Saturn's rings. Dynamic interactions between neutrals, ions, rings, moons and meteoroids produce a highly structured and time variable Saturn system Oxygen in the Saturn system dominates the magnetosphere. Observed fluctuations indicate close interactions with plasma sources. Stochastic events in the E ring may be the ultimate source. The spectral signature of water ice is seen on Phoebe and in Saturn's rings. Water ice is mixed non-uniformly with darker constituents. The high structure of the UV ring reflectance argues that collisional transport dominates ballistic transport in darkening the rings. Our preliminary results support the idea that rings are recycled fragments of moons: the current processes are more important than history and initial conditions. The spectra along the UVIS SOI radial scan indicate varying amounts of water ice. In the A ring, the ice fraction increases outward to a maximum at the outer edge. This large-scale variation is consistent with initially pure ice that has suffered meteoritic bombardment over the age of the Solar system (Cuzzi and Estrada 1998). We also see variations over scales of 1000 - 3000 km, which cannot be explained by this mechanism. Ballistic transport of spectrally neutral extrinsic pollutants from meteoroids striking the rings has a typical throw distance of 6000 km (Durisen et al 1989), too long to explain this finer structure. We propose a class of smaller renewal events, in which a small moon residing within the rings is shattered by an external impactor (Colwell and Esposito 1993, Barbara and Esposito 2002, Esposito and Colwell 2003). The interior of such a body has been shielded from external meteoritic bombardment, and thus contains purer ice. Since the amount of meteoroid pollution provides a rough clock to estimate the age of the rings (Cuzzi and Estrada), these random events reset that clock locally, making the material at that radial location younger and purer. As these purer ring particles collide with others, they exchange regolith, and the range of purer water ice spectrum spreads radially. The radial variation we interpret as due to differential pollution in our data set is consistent with the disruption of several small bodies in the A ring in the last 107 to 108 years. When the small moon Pan (Showalter 1991, R ~ 10 km, now residing in the nearby Encke Gap) is eventually shattered by an external impact (Colwell et al 2000), the gap will close up, and for some 10 to 100 million years thereafter a brighter radial swath of purer water ice at its former location will gradually spread and darken.

Esposito, L.; Colwell, J. E.; UVIS Team

2004-12-01

140

TAPS repair shows value of deformation monitoring  

Energy Technology Data Exchange (ETDEWEB)

For Arctic pipelines, especially those built in river and floodplain areas, a monitoring system is essential for detecting impending pipe damage. This was a major lesson derived from last year's repair and rerouting of a section of the Trans-Alaska Pipeline (TAPS) at milepost (mp) 200. The line at this point crosses a river and floodplain area in which any surface evidence of pipe damage is obliterated, thus making ground surface conditions unreliable indicators of pipe settlement. The wintertime repair project, with rerouted pipe of about 4,000 ft long, cost $27 million. The affected pipe was buried beneath the main channel of the Dietrich River, 200.6 miles from the beginning of the pipeline at Prudhoe Bay, and 84 miles above the Arctic Circle. As part of Alyeska's continuing monitoring program, a corrosion and deformation (C/D) pig traverses the TAPS pipe at regular intervals. This pig has proven helpful in locating places where excessive settlement has caused deformation of the pipe. The C/D pig detects pipe diameter changes as small as 0.25 in. The radial and longitudinal locations of the pipe change have proven quite accurate. A review of the results of the June 1984 C/D pig run revealed a pipe wall ovality anomaly with a sinusoidal shape indicating a wrinkle. This wrinkle was small when compared with other wrinkles Alyeska had found and subsequently repaired. A comparison of previous C/D pig runs for this location revealed a wrinkle with an amplitude of 0.25 in. which had developed in previously smooth pipe in the space of a year.

Simmons, G.G.; Ferrell, J.F.

1986-04-07

 
 
 
 
141

Showing Emulsion Properties with Common Dairy Foods  

Science.gov (United States)

Foods are mixtures of different chemical compounds, and the quality we sense (taste, texture, color, etc.) are all manifestations of its chemical properties. Some of them can be visualized with the aid of simple, safe and inexpensive experiments using dairy products that can be found in any kitchen and using almost exclusively kitchen utensils. In this paper we propose some of them related with food emulsions. Food emulsions cover an extremely wide area of daily-life applications such as milk, sauces, dressings and beverages. Experimentation with some culinary recipes to prepare them and the analyisis of the observed results is close to ideal subject for the introduction of chemical principles, allowing to discuss about the nature and composition of foods, the effects of additives, etc. At the same time it allows to get insights into the scientific reasons that underlie on the recipes (something that it is not usually found in most cookbooks). For example, when making an emulsion like mayonnaise, why the egg yolks and water are the first materials in the bowl , and the oil is added to them rather than in the other way around? How you can "rescue" separate emulsions (mayonnaise)? Which parameters affect emulsion stability? Since safety, in its broad sense, is the first requisite for any food, concerns about food exist throughout the world and the more we are aware of our everyday life, the more likely we will be to deal productively with the consequences. On the other hand, understanding what foods are and how cooking works destroys no delightful mystery of the art of cuisine, instead the mystery expands.

Bravo-Diaz, Carlos; Gonzalez-Romero, Elisa

1996-09-01

142

DAST in Flight Showing Diverging Wingtip Oscillations  

Science.gov (United States)

Two BQM-34 Firebee II drones were modified with supercritical airfoils, called the Aeroelastic Research Wing (ARW), for the Drones for Aerodynamic and Structural Testing (DAST) program, which ran from 1977 to 1983. In this view of DAST-1 (Serial # 72-1557), taken on June 12, 1980, severe wingtip flutter is visible. Moments later, the right wing failed catastrophically and the vehicle crashed near Cuddeback Dry Lake. Before the drone was lost, it had made two captive and two free flights. Its first free flight, on October 2, 1979, was cut short by an uplink receiver failure. The drone was caught in midair by an HH-3 helicopter. The second free flight, on March 12, 1980, was successful, ending in a midair recovery. The third free flight, made on June 12, was to expand the flutter envelope. All of these missions launched from the NASA B-52. From 1977 to 1983, the Dryden Flight Research Center, Edwards, California, (under two different names) conducted the DAST Program as a high-risk flight experiment using a ground-controlled, pilotless aircraft. Described by NASA engineers as a 'wind tunnel in the sky,' the DAST was a specially modified Teledyne-Ryan BQM-34E/F Firebee II supersonic target drone that was flown to validate theoretical predictions under actual flight conditions in a joint project with the Langley Research Center, Hampton, Virginia. The DAST Program merged advances in electronic remote control systems with advances in airplane design. Drones (remotely controlled, missile-like vehicles initially developed to serve as gunnery targets) had been deployed successfully during the Vietnamese conflict as reconnaissance aircraft. After the war, the energy crisis of the 1970s led NASA to seek new ways to cut fuel use and improve airplane efficiency. The DAST Program's drones provided an economical, fuel-conscious method for conducting in-flight experiments from a remote ground site. DAST explored the technology required to build wing structures with less than normal stiffness. This was done because stiffness requires structural weight but ensures freedom from flutter-an uncontrolled, divergent oscillation of the structure, driven by aerodynamic forces and resulting in structural failure. The program used refined theoretical tools to predict at what speed flutter would occur. It then designed a high-response control system to counteract the motion and permit a much lighter wing structure. The wing had, in effect, 'electronic stiffness.' Flight research with this concept was extremely hazardous because an error in either the flutter prediction or control system implementation would result in wing structural failure and the loss of the vehicle. Because of this, flight demonstration of a sub-scale vehicle made sense from the standpoint of both safety and cost. The program anticipated structural failure during the course of the flight research. The Firebee II was a supersonic drone selected as the DAST testbed because its wing could be easily replaced, it used only tail-mounted control surfaces, and it was available as surplus from the U. S. Air Force. It was capable of 5-g turns (that is, turns producing acceleration equal to 5 times that of gravity). Langley outfitted a drone with an aeroelastic, supercritical research wing suitable for a Mach 0.98 cruise transport with a predicted flutter speed of Mach 0.95 at an altitude of 25,000 feet. Dryden and Langley, in conjunction with Boeing, designed and fabricated a digital flutter suppression system (FSS). Dryden developed an RPRV (remotely piloted research vehicle) flight control system; integrated the wing, FSS, and vehicle systems; and conducted the flight program. In addition to a digital flight control system and aeroelastic wings, each DAST drone had research equipment mounted in its nose and a mid-air retrieval system in its tail. The drones were originally launched from the NASA B-52 bomber and later from a DC-130. The DAST vehicle's flight was monitored from the sky by an F-104 chase plane. When the DAST's mission ended, it deployed a parachute and then a specially eq

1980-01-01

143

Nissan at 33rd Tokyo Motor Show; Dai 33 kai Tokyo Motor show  

Energy Technology Data Exchange (ETDEWEB)

The Tokyo Motor Show is one of the leading exhibition opportunities for automobile companies world wide in terms of both scale and features, including the number of visitors as well as the devotion of each participant. For many years, we have worked hard to excell at each session of this show, (through the display of concept cars and Nissan Motor's technological developments), the show has played an increasing role in enhancing Nissan's brand image. At the 33rd Tokyo Motor Show in October 1999 was held at a time when Nissan had drawn the attention of the market because of its tic-up with Renault. Nissan demonstrated a revolutionary change through the introduction of concept cars, environmental technology, safety technology, new models, and so on. (author)

Sekiguchi, M. [Nissan Motor Co. Ltd., Tokyo (Japan)

2000-01-01

144

Comportamento agressivo em shows musicais: analisando notícias de jornal impresso  

Directory of Open Access Journals (Sweden)

Full Text Available This paper reports a content analysis of the newspaper articles dealing with aggressive behavior in music shows. This analysis permits an understanding of the characteristics of these situations, the aggressive behaviors in shows, and the way in which the print media treat the subject. Despite of the newspapers’ influence on public opinion formation, that is, the transmission of attitudes and behavior repertoires, this kind of analysis is rarely reported in Brazilian social psychological literature. Some 31 newspaper articles were content analyzed as to aggressive behavior during music shows. Results indicate that aggressive behaviors occur in shows of most varied musical styles. Results are discussed on the basis of social cognitive theory.

Carlos Eduardo Pimentel

2011-08-01

145

Showing and Telling Farming: Agricultural Shows and Re-Imaging British Agriculture  

Science.gov (United States)

Some actors in the ''mainstream'' agricultural sector are beginning to engage in strategies of influencing public perceptions of farming, responding to public anxieties over industrialised agriculture and to a supposed separation of non-farming publics from food production. This paper focuses on agricultural shows as sites and events central to…

Holloway, Lewis

2004-01-01

146

Fort McMurray oil sands trade show: official show guide  

Energy Technology Data Exchange (ETDEWEB)

The trade show, of which the official show guide is only available, showcased new oil sands technology in mining, construction, processing, materials handling, environmental, and communications and provides a list of exhibitors with expertise. The Petroleum Society of CIM present a technical seminar on oil sands mining, extraction and upgrading techniques. Papers, which are not included separately, were given on artificial lift, in in-situ and bitumen; reservoir geomechanics, sand control, Syncrude's Aurora project, the future of pipe connection, screening of oil sand slurry, the Stormceptor system, the F-500: a new fire fighting and Hazmat control project, white paper on new technology in eddy current and remote field testing, the TJ 4000: high velocity oxygen fuel system.

NONE

1999-07-01

147

?Branding At Trade Shows : ?How subcontractors use trade shows to strengthen their brand  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Background: Branding is a way for companies to differentiate their products and services from its competitors in the fierce competition in business today. This phenomena has up until recently mostly been used in the B2C context, but the importance of branding in the B2B context has been more and more acknowledged. Trade shows are a good way to find customers, and to display and sell products, but can it also be used to strengthen the brand of the exhibiting company? According to Nordiska Unde...

Andersson, Karl-johan; Alm, Simon; Andersson, Jo?rgen

2007-01-01

148

Nuclear plant irradiated steel handbook  

International Nuclear Information System (INIS)

This reference handbook presents selected information extracted from the EPRI reactor surveillance program database, which contains the results from surveillance program reports on 57 plants and 116 capsules. Tabulated data includes radiation induced temperature shifts, capsule irradiation conditions and statistical features of the Charpy V-notch curves. General information on the surveillance materials is provided and the Charpy V-notch energy results are presented graphically

149

Show-through cancellation in scans of duplex printed documents.  

Science.gov (United States)

In scanning pages with double-sided printing, often the printing on the back-side shows through in the scan of the front-side because the paper is not completely opaque. This show-through is an undesirable artifact that one would like to remove. In this paper, the phenomenon of show-through is analyzed using first physical principles to obtain a simplified mathematical model. The model is linearized using suitable transformations and simplifying approximations. Based on the linearized model, an adaptive linear filtering scheme is developed for the electronic removal of show-through using scans of both sides of the document. Experimental results demonstrating the effectiveness of the method developed are presented. PMID:18249664

Sharma, G

2001-01-01

150

Application of subsize specimens in nuclear plant life extension  

International Nuclear Information System (INIS)

The US Department of Energy is sponsoring a research effort through Sandia National Laboratories and the University of Missour-Rolla to test a correlation for the upper shelf energy (USE) values obtained from the impact testing of subsize Charpy V-notch specimens to those obtained from the testing of full size samples. The program involves the impact testing of unirradiated and irradiated full, half, and third size Charpy V-notch specimens. To verify the applicability of the correlation on LWR materials unirradiated and irradiated full, half, and third size Charpy V-notch specimens of a commercial pressure vessel steel (ASTM A533 Grade B) will be tested. This paper will provide details of the program and present results obtained from the application of the developed correlation methodology to the impact testing of the unirradiated full, half, and third size A533 Grade B Charpy V-notch specimens

151

O show da Química: motivando o interesse científico The Chemistry show: motivating the scientific interest  

Directory of Open Access Journals (Sweden)

Full Text Available The aim of this article is to provide the understanding of the chemical world that underlies everything around us by introducing basic chemical concepts and their everyday applications. The specific topics presented were selected according to their relevance and their ability to be presented as an exhibition. This format is based on the visual effects that help the public to see abstract descriptions in a concrete form. In addition, a soundtrack is used to stimulate the affective intelligence and relax the public. According to the results obtained here, we can conclude that chemical demonstrations, combined with music, help the presentation of scientific topics and motivate and facilitate the "chemistry communication".

Agnaldo Arroio

2006-02-01

152

Intercan '99 - the Calgary oil and gas show: official show guide  

International Nuclear Information System (INIS)

The official show guide features a list of exhibitor profiles and list of products and services. A leading technology seminar series, held during Intercan '99 presented 47 papers on such topics as economically viable benzene pollution solution, micro turbines for effective flare gas treatment, cost effective and technologically advanced silicated drilling fluids, pressure enhancement of marginal gas, predictive maintenance tools, advantages of the inclined free water knockout (IFWKO), isotherm systems, hands-free automatic oil well optimization, on-site bioremediation of hydrocarbon contaminated drill cuttings through composting technologies, a new environmentally acceptable drill mud oil and real-time well monitoring case studies. Papers were also presented on: Exacta's all in one series XI controller for air/fuel radio control, more efficient and cost effective coiled tubing technology, pressure enhancement of marginal gas, hands-free automatic oil well optimization, economically viable benzene pollution solution, new products to solve the soluble salt dilemma, real-time hydrocarbon reservoir management using PC based reservoir simulators,real-time bottom hole pressure monitoring system for fracturing operations and remote modular facilities and accommodation for maximized personnel productivity

153

O show da Química: motivando o interesse científico / The Chemistry show: motivating the scientific interest  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese [...] Abstract in english The aim of this article is to provide the understanding of the chemical world that underlies everything around us by introducing basic chemical concepts and their everyday applications. The specific topics presented were selected according to their relevance and their ability to be presented as an e [...] xhibition. This format is based on the visual effects that help the public to see abstract descriptions in a concrete form. In addition, a soundtrack is used to stimulate the affective intelligence and relax the public. According to the results obtained here, we can conclude that chemical demonstrations, combined with music, help the presentation of scientific topics and motivate and facilitate the "chemistry communication".

Agnaldo, Arroio; Káthia M., Honório; Karen C., Weber; Paula, Homem-de-Mello; Maria Teresa do Prado, Gambardella; Albérico B. F. da, Silva.

2006-02-01

154

The Swimmer's view: does it really show what it is supposed to show? A retrospective study  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract Background One of the basic principles in the primary survey of a trauma patient is immobilisation of the cervical spine till cleared of any injury. Lateral cervical spine radiograph is one of the important initial radiographic assessments. More than often additional radiographs like the Swimmer's view are necessary for adequate visualisation of the cervical spine. How good is the Swimmer's view in visualisation of the cervical spine after an inadequate lateral cervical spine radiograph? Methods 100 Swimmer's view radiographs randomly selected over a 2 year period in trauma patients were included for the study. All the patients had inadequate lateral cervical spine radiographs. The radiographs were assessed with regards to their adequacy by a single observer. The criteria for adequacy were adequate visualisation of the C7 body, C7/T1 junction and the soft tissue shadow. Results Only 55% of the radiographs were adequate. None of the inadequate radiographs provided adequate visualisation of the C7 body and the C7/T1 junction. In 42.2% radiographs the soft tissue shadow was unclear. Poor exposure accounted for 53% of the inadequacies while overlapping bones accounted for the rest. Conclusion Clearing the cervical spine prior to removing triple immobilisation is essential in a trauma patient. This needs adequate visualisation from C1 to C7/T1 junction. In our study Swimmer's views did not satisfactorily provide adequate visualisation of the cervical spine in trauma patients. We recommend screening the cervical spine by a CT scan when the cervical spine lateral radiographs and Swimmer's views are inadequate.

Yesupalan Rajam SU

2008-01-01

155

Courtship and genetic quality: asymmetric males show their best side  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Fluctuating asymmetry (FA), the small random deviations from perfect morphological symmetry that result during development, is ubiquitous throughout the animal kingdom. In many species, FA seems to play a role in mate choice, perhaps because it signals an individual's genetic quality and health. However, the relationship between an individual's FA and behaviour is generally unknown: what do more asymmetric individuals do about their own asymmetry? We now show for the first time that individua...

Gross, Mart R.; Suk, Ho Young; Robertson, Cory T.

2007-01-01

156

The use of computerized tomography in patients showing tardive dyskinesia  

International Nuclear Information System (INIS)

29 patients showing moderate to markedly pronounced tardive dyskinesia (TD) and a further 29 control patients (C) under a similar long-term medication with neuroleptics that had been so chosen as to match the age and sex distributions of the former group were subjected to computered tomography, neurological examination and psychological testing. The results did not point to any correlations between the structural changes and duration of treatment and the clinical signs or symptoms of extrapyramidal disorder. This was taken as further evidence in support of the theory that the initial damage in tardive dyskinesia mainly is at the level of the basal ganglia. (orig./MG)

157

Oil and gas shows numerous in Nama basin, southern Africa  

Energy Technology Data Exchange (ETDEWEB)

No local sources of oil and gas are on production in southwestern Africa. The as yet undeveloped Kudu gas field off Namibia is the first major discovery, but there are numerous shows in the onshore Nama basin that suggest there could be significant accumulations of hydrocarbons present. The Nama basin occupies 350,000 sq km of southern Namibia, western Botswana, and northwestern South Africa and contains 10 km or more of Neoproterozoic and Cambrian sediment. National petroleum Corp. of Namibia recently embarked on an assessment of the prospectivity of the basin, and there the authors report some of the first results.

Walter, M. [Rix and Walter Pty. Ltd., Bawley Point, New South Wales (Australia); Swart, R. [National Petroleum Corp. of Namibia Pty. Ltd., Windhoek (Namibia); Summons, R. [Australian Geological Survey Organisation, Canberra (Australia)

1996-11-25

158

Tests show how oil muds increase shale stability  

International Nuclear Information System (INIS)

This article describes the problems and processes involved in preserving shale cores at a rig site and testing the shale on the downhole simulation cell (DSC) with an oil mud. Data on the composition of the shale as determined by x-ray diffraction, thin section analysis and atomic absorption are presented. Results of three DSC tests are given showing how the shale in the region around the wellbore can be affected by oil mud. This article discusses the development of procedures and presents part of the baseline data for the comparison of the performance of water based systems

159

SUMOylated IRF-1 shows oncogenic potential by mimicking IRF-2  

Energy Technology Data Exchange (ETDEWEB)

Interferon regulatory factor-1 (IRF-1) is an interferon-induced transcriptional activator that suppresses tumors by impeding cell proliferation. Recently, we demonstrated that the level of SUMOylated IRF-1 is elevated in tumor cells, and that SUMOylation of IRF-1 attenuates its tumor-suppressive function. Here we report that SUMOylated IRF-1 mimics IRF-2, an antagonistic repressor, and shows oncogenic potential. To demonstrate the role of SUMOylated IRF-1 in tumorigenesis, we used SUMO-IRF-1 recombinant protein. Stable expression of SUMO-IRF-1 in NIH3T3 cells resulted in focus formation and anchorage-independent growth in soft agar. Inoculation of SUMO-IRF-1-transfected cells into athymic nude mice resulted in tumor formation and infiltration of adipose tissues. Finally, we demonstrated that SUMO-IRF-1 transforms NIH3T3 cells in a dose-dependent manner suggesting that SUMOylated IRF-1 may act as an oncogenic protein in tumor cells.

Park, Sun-Mi [Yonsei University, Division of Biological Science and Technology, Wonju 220-100 (Korea, Republic of); School of Biological Sciences and Biotechnology, Chonnam National University, Gwangju 500-757 (Korea, Republic of); Chae, Myounghee [Clinical Trial Center for Functional Foods, Chonbuk National University Hospital, Jeonju 561-712 (Korea, Republic of); Kim, Bo-Kyoung [Yonsei University, Division of Biological Science and Technology, Wonju 220-100 (Korea, Republic of); Seo, Taegun [Department of Life Science, Dongguk Univ-Seoul, Seoul 100-715 (Korea, Republic of); Jang, Ik-Soon; Choi, Jong-Soon [Proteome Research Team, Korea Basic Science Institute, Daejeon 305-333 (Korea, Republic of); Kim, Il-Chul [School of Biological Sciences and Biotechnology, Chonnam National University, Gwangju 500-757 (Korea, Republic of); Lee, Je-Ho [Molecular Therapy Research Center, Sungkyunkwan University, Seoul 135-710 (Korea, Republic of); Park, Junsoo, E-mail: junsoo@yonsei.ac.kr [Yonsei University, Division of Biological Science and Technology, Wonju 220-100 (Korea, Republic of)

2010-01-01

160

SUMOylated IRF-1 shows oncogenic potential by mimicking IRF-2  

International Nuclear Information System (INIS)

Interferon regulatory factor-1 (IRF-1) is an interferon-induced transcriptional activator that suppresses tumors by impeding cell proliferation. Recently, we demonstrated that the level of SUMOylated IRF-1 is elevated in tumor cells, and that SUMOylation of IRF-1 attenuates its tumor-suppressive function. Here we report that SUMOylated IRF-1 mimics IRF-2, an antagonistic repressor, and shows oncogenic potential. To demonstrate the role of SUMOylated IRF-1 in tumorigenesis, we used SUMO-IRF-1 recombinant protein. Stable expression of SUMO-IRF-1 in NIH3T3 cells resulted in focus formation and anchorage-independent growth in soft agar. Inoculation of SUMO-IRF-1-transfected cells into athymic nude mice resulted in tumor formation and infiltration of adipose tissues. Finally, we demonstrated that SUMO-IRF-1 transforms NIH3T3 cells in a dose-dependent manner suggesting that SUMOylated IRF-1 may act as an oncogenic protein in tumor cells.

 
 
 
 
161

Attention and blood lactate levels in equestrians performing show jumping.  

Science.gov (United States)

In equestrian show jumping, attention is particularly important to ensure maximum accuracy. Due to the anaerobic nature of the jumping and its requirement for precision coordination between human and horse, there may be a relation between the onset of lactic threshold and decrease in attention. In 12 healthy and injury-free equestrians (6 men, 6 women), the effects (blood lactate and glucose) of a show jumping course (250 m long with eight vertical obstacles with a height of 1.15 m height) on capacity and selectivity of attention was assessed. A typical reaction time paradigm and test of divided attention were administered. At the end of the course a significant increase of blood lactate was observed, whereas blood glucose did not significantly change. A deterioration of attention (intensity and selectivity) and a worsening of performance with increasing of blood lactate were observed. The present results led to the conclusion that the increase in blood lactate that occurs in riders executing a show jumping course is associated with worsening of both attentive capabilities and performance. PMID:25068743

Perciavalle, Valentina; Di Corrado, Donatella; Scuto, Claudia; Perciavalle, Vincenzo; Coco, Marinella

2014-06-01

162

Eccentric muscle challenge shows osteopontin polymorphism modulation of muscle damage.  

Science.gov (United States)

A promoter polymorphism of the osteopontin (OPN) gene (rs28357094) has been associated with multiple inflammatory states, severity of Duchenne muscular dystrophy (DMD) and muscle size in healthy young adults. We sought to define the mechanism of action of the polymorphism, using allele-specific in vitro reporter assays in muscle cells, and a genotype-stratified intervention in healthy controls. In vitro reporter constructs showed the G allele to respond to estrogen treatment, whereas the T allele showed no transcriptional response. Young adult volunteers (n = 187) were enrolled into a baseline study, and subjects with specific rs28357094 genotypes enrolled into an eccentric muscle challenge intervention [n = 3 TT; n = 3 GG/GT (dominant inheritance model)]. Female volunteers carrying the G allele showed significantly greater inflammation and increased muscle volume change as determined by magnetic resonance imaging T1- and T2-weighted images after eccentric challenge, as well as greater decrement in biceps muscle force. Our data suggest a model where the G allele enables enhanced activities of upstream enhancer elements due to loss of Sp1 binding at the polymorphic site. This results in significantly greater expression of the pro-inflammatory OPN cytokine during tissue remodeling in response to challenge in G allele carriers, promoting muscle hypertrophy in normal females, but increased damage in DMD patients. PMID:24626632

Barfield, Whitney L; Uaesoontrachoon, Kitipong; Wu, Chung-Sheih; Lin, Stephen; Chen, Yue; Wang, Paul C; Kanaan, Yasmine; Bond, Vernon; Hoffman, Eric P

2014-08-01

163

The postmitotic Saccharomyces cerevisiae after spaceflight showed higher viability  

Science.gov (United States)

The budding yeast Saccharomyces cerevisiae has been proposed as an ideal model organism for clarifying the biological effects caused by spaceflight conditions. The postmitotic S. cerevisiae cells onboard Practice eight recoverable satellite were subjected to spaceflight for 15 days. After recovery, the viability, the glycogen content, the activities of carbohydrate metabolism enzymes, the DNA content and the lipid peroxidation level in yeast cells were analyzed. The viability of the postmitotic yeast cells after spaceflight showed a three-fold increase as compared with that of the ground control cells. Compared to the ground control cells, the lipid peroxidation level in the spaceflight yeast cells markedly decreased. The spaceflight yeast cells also showed an increase in G2/M cell population and a decrease in Sub-G1 cell population. The glycogen content and the activities of hexokinase and succinate dehydrogenase significantly decreased in the yeast cells after spaceflight. In contrast, the activity of malate dehydrogenase showed an obvious increase after spaceflight. These results suggested that microgravity or spaceflight could promote the survival of postmitotic S. cerevisiae cells through regulating carbohydrate metabolism, ROS level and cell cycle progression.

Yi, Zong-Chun; Li, Xiao-Fei; Wang, Yan; Wang, Jie; Sun, Yan; Zhuang, Feng-Yuan

2011-06-01

164

32 CFR 552.78 - “Show cause” hearing.  

Science.gov (United States)

...Solicitation on Military Reservations § 552.78 “Show cause” hearing. Before suspending the...the company and the agent will have a chance to show cause why the action should not be taken. “Show cause” is an opportunity for the...

2010-07-01

165

Firm squelched study showing risk of HIV in hemophilia drug.  

Science.gov (United States)

Armour Pharmaceutical Co., of Collegeville, PA, suppressed research showing that its heat-treating process did not effectively kill HIV. According to Canada's Commission of Inquiry on the Blood System, the heating process failed to destroy HIV in Factorate, Armour's blood-clotting medicine for hemophiliacs. According to company documents, Armour commissioned virologist Alfred Prince to evaluate the methods the company uses to rid Factorate of HIV. Prince found the heating method to be ineffective; these findings differed from Armour's own studies. Armour prohibited Prince from publishing his findings, claiming his results would only serve to confuse the scientific community and the public. Armour is a defendant in 321 pending lawsuits brought by HIV-infected hemophiliacs in the U.S., Canada, and the United Kingdom. PMID:11362848

1995-10-20

166

Atlantic salmon show capability for cardiac acclimation to warm temperatures.  

Science.gov (United States)

Increases in environmental temperature predicted to result from global warming have direct effects on performance of ectotherms. Moreover, cardiac function has been observed to limit the tolerance to high temperatures. Here we show that two wild populations of Atlantic salmon originating from northern and southern extremes of its European distribution have strikingly similar cardiac responses to acute warming when acclimated to common temperatures, despite different local environments. Although cardiac collapse starts at 21-23?°C with a maximum heart rate of ~150 beats per min (bpm) for 12?°C-acclimated fish, acclimation to 20?°C considerably raises this temperature (27.5?°C) and maximum heart rate (~200?bpm). Only minor population differences exist and these are consistent with the warmer habitat of the southern population. We demonstrate that the considerable cardiac plasticity discovered for Atlantic salmon is largely independent of natural habitat, and we propose that observed cardiac plasticity may aid salmon to cope with global warming. PMID:24957572

Anttila, Katja; Couturier, Christine S; Overli, Oyvind; Johnsen, Arild; Marthinsen, Gunnhild; Nilsson, Göran E; Farrell, Anthony P

2014-01-01

167

Siah2-deficient mice show impaired skin wound repair.  

Science.gov (United States)

Hypoxia is associated with the dermal wound healing process and hypoxia signaling is presumed to be crucial for normal wound repair. The Siah2 ubiquitin ligase controls the abundance of hypoxia-inducible factor-1 alpha, and loss of Siah2 results in destabilization of hypoxia-inducible factor-1 alpha under hypoxia. Utilizing Siah2(-/-) mice we demonstrate that cutaneous wound healing is impaired in these mice. Wounds in Siah2(-/-) mice heal slower and are associated with delayed induction of myofibroblast infiltration and reduced collagen deposition. This coincides with delayed angiogenesis and reduced macrophage infiltration into the wounds of Siah2(-/-) mice. We furthermore demonstrate that primary Siah2(-/-) dermal fibroblasts have reduced migratory capacities and produce less collagen than wild-type fibroblasts. Additionally, Siah2(-/-) fibroblasts showed conserved responses to transforming growth factor-? at the receptor level (pSmad 2C activation) but reduced responses downstream. Together, our data show, for the first time, that Siah2 is involved as a positive regulator in the wound healing response. Understanding the role of hypoxia signaling in tissue repair and fibrosis and interference with the hypoxia signaling pathway via regulation of Siah2 may provide new targets for clinical regulation of fibrosis and scarring. PMID:23627548

Musyoka, James N; Liu, Mira C P; Pouniotis, Dodie S; Wong, Christina S F; Bowtell, David D; Little, Peter J; Getachew, Robel; Möller, Andreas; Darby, Ian A

2013-01-01

168

PROTOTIPE VIDEO EDITOR DENGAN MENGGUNAKAN DIRECT X DAN DIRECT SHOW  

Directory of Open Access Journals (Sweden)

Full Text Available Technology development had given people the chance to capture their memorable moments in video format. A high quality digital video is a result of a good editing process. Which in turn, arise the new need of an editor application. In accordance to the problem, here the process of making a simple application for video editing needs. The application development use the programming techniques often applied in multimedia applications, especially video. First part of the application will begin with the video file compression and decompression, then we'll step into the editing part of the digital video file. Furthermore, the application also equipped with the facilities needed for the editing processes. The application made with Microsoft Visual C++ with DirectX technology, particularly DirectShow. The application provides basic facilities that will help the editing process of a digital video file. The application will produce an AVI format file after the editing process is finished. Through the testing process of this application shows the ability of this application to do the 'cut' and 'insert' of video files in AVI, MPEG, MPG and DAT formats. The 'cut' and 'insert' process only can be done in static order. Further, the aplication also provide the effects facility for transition process in each clip. Lastly, the process of saving the new edited video file in AVI format from the application. Abstract in Bahasa Indonesia : Perkembangan teknologi memberi kesempatan masyarakat untuk mengabadikan saat - saat yang penting menggunakan video. Pembentukan video digital yang baik membutuhkan proses editing yang baik pula. Untuk melakukan proses editing video digital dibutuhkan program editor. Berdasarkan permasalahan diatas maka pada penelitian ini dibuat prototipe editor sederhana untuk video digital. Pembuatan aplikasi memakai teknik pemrograman di bidang multimedia, khususnya video. Perencanaan dalam pembuatan aplikasi tersebut dimulai dengan pembentukan kompresi dan dekompresi file video, kemudian dilanjutkan dengan proses editing terhadap file video digital. Selain itu program juga dilengkapi dengan fasilitas untuk mendukung proses editing. Aplikasi tersebut dibuat dengan Microsoft Visual C++ dengan menggunakan teknologi DirectX, khususnya DirectShow. Aplikasi tersebut meyediakan fasilitas - fasilitas dasar yang membantu proses editing pada video digital. Dengan aplikasi tersebut dihasilkan file video baru dalam format AVI yang terbentuk dari proses editing yang dilakukan. Hasil pengujian menunjukkan kemampuan aplikasi melakukan proses pemotongan dan penyisipan file video dalam format AVI, MPEG, MPG dan DAT. Proses pemotongan dan penyisipan dilakukan dengan urutan yang statis. Selain itu aplikasi juga menyediakan efek antara masing - masing clip. Dan yang terakhir melakukan proses penyimpanan satu file dalam format AVI yang terbentuk dari proses editing dalam aplikasi. Kata kunci: Multimedia, Video Editor, Direct-X, Direct-Show, AVI, MPG.

Djoni Haryadi Setiabudi

2004-01-01

169

"The George Lopez Show": The Same Old Hispano?  

Science.gov (United States)

"The George Lopez Show" is the first successful television show with a Latino in a leading role that features Hispanic material since Freddie Prinze's thirty-year-old sitcom, "Chico and the Man." This study seeks to assess how Latinos are presented on "The George Lopez Show." A content analysis reveals that the show perpetuates some of the…

Markert, John

2007-01-01

170

Cassini UVIS observations show an active Saturn system  

Science.gov (United States)

The Cassini Ultraviolet Imaging Spectrograph (UVIS) is part of the remote sensing payload of the NASA/ESA Cassini spacecraft. This spectrograph includes channels for extreme UV and far UV spectroscopic imaging, high speed photometry of stellar occultations, solar EUV occultation, and a hydrogen/deuterium absorption cell. We report our initial results from Saturn approach; systematic mosaics of the Saturn system; Phoebe; Saturn orbit insertion and the first Titan flyby. Dynamic interactions between neutrals, ions, rings, moons and meteoroids produce a highly structured and time variable Saturn system. Oxygen in the Saturn system dominates the magnetosphere. Observed fluctuations indicate close interactions with plasma sources. Stochastic events in the E ring may be the ultimate source. The spectral signature of water ice is seen on Phoebe and in Saturn's rings. Water ice is mixed non-uniformly with darker constituents. The high structure of the UV ring reflectance argues that collisional transport dominates ballistic transport in darkening the rings. Titan emissions show atomic, molecular and ionized nitrogen. Auroral emissions from Saturn match electron excited molecular hydrogen. Our preliminary results support the idea that rings are recycled fragments of moons: the current processes are more important than history and initial conditions.

Esposito, L. W.; Colwell, J. E.; Hallett, J. T.; Hansen, C. J.; Hendrix, A. R.; Keller, H. U.; Korth, A.; Larsen, K.; McClintock, W. E.; Pryor, W. R.; Reulke, R.; Shemansky, D. E.; Stewart, A. I. F.; West, R. A.; Ajello, J. A.; Yung, Y. L.

2004-11-01

171

Management in a neotropical show cave: planning for invertebrates conservation  

Directory of Open Access Journals (Sweden)

Full Text Available Lapa Nova is a dolomitic cave about 4.5 km long located in northwestern Minas Gerais state, Brazil. The cave experiences intense tourism, concentrated over a single period of the year, during the Feast of Our Lady of Lapa. In order to evaluate the impacts felt by the invertebrate community from this tourism, a new methodology was proposed. Four types of areas (intense visitation area, outlying visitation areas, moderate visitation areas and no-visitation areas were sampled for invertebrates. There was one sampling prior and another on the last day of the 128th feast, to evaluate the effects of visitation on cave-dwelling invertebrates. Results show that invertebrate populations residing in more intensely visited areas of the cave undergo changes in distribution following the event. As a consequence of tourism, invertebrates shift to outlying locations from the visited area, which serve as refuges to the communities. Apparently, the fact that there are places inside Lapa Nova inaccessible to tourists reduces the impact suffered by the invertebrate community, as those sites serve as refuges for cave-dwelling organisms during the pilgrimage. A proper management plan was devised for the tourism/religious use of the cave. It consists basically of delimiting marked pathways for tourists, allowing invertebrates to seek shelter at locations outside visited areas and keeping no-visitation areas off-limits to tourism based on the results of the visitation effects on cave-dwelling invertebrates.

Thais Giovannini Pellegrini

2012-07-01

172

Astronomers Make "Movie" of Radio Images Showing Supernova Explosion  

Science.gov (United States)

Astronomers using an international network of radio telescopes have produced a "movie" showing details of the expansion of debris from an exploding star. Their sequence of images constitutes the best determination yet made of the details of a new supernova remnant, and already has raised new questions about such events. The scientists used radio telescopes in Europe and the United States, including the National Science Foundation's Very Large Array (VLA) and Very Long Baseline Array (VLBA), to make very high- resolution images of Supernova 1993J, which was discovered by a Spanish amateur astronomer on March 28, 1993 in the galaxy M81, some 11 million light-years distant in the constellation Ursa Major. Their results are reported in the December 1 issue of the journal Science. The "movie" is based on five images of the supernova, made during 1993 and 1994. The work was done by: Jon Marcaide and Eduardo Ros of the University of Valencia, Spain; Antxon Alberdi of the Special Laboratory for Astrophysics and Fundamental Physics of Madrid, Spain and the Institute of Astrophysics at Andalucia, Spain; Philip Diamond of the National Radio Astronomy Observatory in Socorro, NM; Irwin Shapiro of the Harvard-Smithsonian Center for Astrophysics in Cambridge, MA; Jose-Carlos Guirado, Dayton Jones and Robert Preston of the Jet Propulsion Laboratory in Pasadena, CA; Thomas Krichbaum and Arno Witzel of the Max-Planck Institute for Radioastronomy in Bonn, Germany; Franco Mantovani of the Institute of Radioastronomy in Bologna, Italy; Antonio Rius of the Special Laboratory for Astrophysics and Fundamental Physics of Madrid, Spain and the Center for Advanced Studies at Blanes, Spain; Richard Schilizzi of the Joint Institute for VLBI in Europe and Leiden Observatory in the Netherlands; Corrado Trigilio of the Institute of Radioastronomy in Noto, Italy; and Alan Whitney of the MIT- Haystack Observatory in Massachusetts. The capability to make such high-quality images with widely- dispersed radio telescopes has existed for only a few years. Supernova 1993J was the first one that was both close enough and had radio emission strong enough to enable scientists to make such detailed images. While the circular images show that the explosion debris is expanding symmetrically, the radio emission is stronger on one side of the shell. The explanation for this is unclear. Some astronomers have suggested that the stronger emission could result from the debris interacting with a companion star orbiting the one that exploded. The researchers believe that their sequence of images, with the stronger emission persisting for months after the explosion, makes the companion-star hypothesis unlikely. Previous radio observations of older and larger supernova shells have revealed protrusions within the shell. The latest images, however, show no such protrusions. This places limits on theories of how the protrusions form. In addition, the new images show that Supernova 1993J's debris shell has shown no signs yet of slowing due to interaction with material surrounding it. The material from the star's explosion is moving at nearly 10,000 miles per second, according to the researchers. At that speed, the material would travel the distance from the Earth to Saturn in one day. When the angular expansion rate of the supernova debris measured by the radio observatories is combined with the expansion speed of the same debris, measured by optical astronomers, it is possible to obtain an accurate value of the distance to M81. The value determined, 11 million light-years, is similar to that obtained by other, independent, means. This is important, as astronomers continue to seek more accurate distances to celestial objects to better gauge the actual size of the Universe. In addition to the VLA and several antennas of the VLBA, the scientists used German and Italian radio telescopes, as well as NASA facilities in California and Spain.

1995-11-01

173

9 CFR 354.247 - Table showing types of materials.  

Science.gov (United States)

...2010-01-01 false Table showing types of materials. 354.247 Section 354.247 Animals and Animal Products FOOD SAFETY...and Precautions Against Contamination of Products § 354.247 Table showing types of materials....

2010-01-01

174

Research Shows Cataract Surgery Can Reduce Hip Fracture Risk  

Science.gov (United States)

... sponsored Research Shows Cataract Surgery Can Reduce Hip Fracture Risk 08/01/2012 09:00:00 AM ... Medicare beneficiaries shows that the risk of hip fractures was significantly reduced in patients who had had ...

175

77 FR 1513 - Air Show and Air Races; Public Hearing  

Science.gov (United States)

...NATIONAL TRANSPORTATION SAFETY BOARD Air Show and Air Races; Public Hearing TIME AND DATE: 9 a.m., Tuesday...examine current regulations and oversight practices for air shows and air races, describe procedures used for planning...

2012-01-10

176

Concussion Recovery Can Reverse After Return to Activity, Study Shows  

Science.gov (United States)

... Recovery Can Reverse After Return to Activity, Study Shows Expert and researcher say the findings highlight need ... to have recovered from a concussion may actually show a subtle worsening in a particular mental ability ...

177

Journey to the Stars Educator's Guide: Teaching with the Show  

Science.gov (United States)

This is an educators guide to accompany the Journey to the Stars planetarium show. The materials include a section, titled Teaching With the Show, containing guiding questions to encourage class discussions about the life cycle of stars.

178

Boys with Autism Show Certain Grammar Skills in Study  

Science.gov (United States)

... this page, please enable JavaScript. Boys With Autism Show Certain Grammar Skills in Study They were able ... wonder whether some children with autism might also show related strengths, as yet unrecognized," study senior author ...

179

GAMS results  

Energy Technology Data Exchange (ETDEWEB)

In this contribution some recent results of the GAMS collaboration are shown. Some of them are still preliminary. Results on the following reactions are presented: {pi}{sup -}p {yields} ({eta} {pi}{sup 0}) n, {pi}{sup -}p {yields} ({omega} {pi}{sup 0}) n, and {pi}{sup -}p{yields} {pi}{sup -}p ({eta}{eta}) centrally produced. (orig.).

Boutemeur, M. (CERN, Geneva (Switzerland)); Peigneux, J.P. (Grenoble-1 Univ., 74 - Annecy (France). Lab. de Physique des Particules); Donskov, S.V.; Inyakin, A.V.; Kachanov, V.A.; Khaustov, G.V.; Kulik, A.V.; Lednev, A.A.; Prokoshkin, Yu.D.; Rodnov, Yu.V.; Sadovsky, S.A.; Samoylenko, V.D.; Shagin, P.M.; Shtannikov, A.V.; Singovsky, A.V.; Sugonyaev, V.P. (Institute for High Energy Physics, Serpukhov (USSR)); Binon, F.G.; Bricman, C.; Stroot, J.P. (Institut Interuniversitaire des Sciences Nucleaires, Brussels (Belgium)); Bencheikh, B.; Boutemeur, M.; Gouanere, M.; Massonnett, L.; Peigneux, J.P.; Poulet, M. (Grenoble-1 Univ., 74 - Annecy (France). Lab. de Physique des Particules); Alde, D.; Jeppesen, R.G.; Knapp, E.A. (Los Alamos National Lab., NM (USA)); Bellazini, R.; Brez, A.; Massai, M.M.; Torquati, M.R. (Pisa Univ. (Italy) INFN, Pisa (Italy)); Inaba, S.; Kobayashi, M.; Shimizu, H.; Takamatsu, K.; Tsuru, T. (National Lab. for High Energy Physics, Tsukuba (Japan)); GAMS Collaboration

1991-06-01

180

Network MPEG4 stream processing system based on direct show  

International Nuclear Information System (INIS)

This paper introduces network MPEG4 stream processing system based on direct show. The system is implemented using microsoft direct show technology. It retrieves MPEG4 stream from network, operates framing, decoding and rendering in real time. The key technology of the system is design and implementation of direct show source filter. (authors)

 
 
 
 
181

34 CFR 300.194 - Show cause hearing.  

Science.gov (United States)

...hearing. (a) If a show cause hearing is requested, the Secretary...a person to conduct the show cause hearing. The designee must...hearing. (b) At the show cause hearing, the designee considers...and impartial proceeding, to avoid delay, and to maintain...

2010-07-01

182

41 CFR 60-741.64 - Show cause notices.  

Science.gov (United States)

...2010-07-01 2010-07-01 true Show cause notices. 60-741.64 Section...Complaint Procedures § 60-741.64 Show cause notices. When the Deputy Assistant...issue a notice requiring the contractor to show cause, within 30 days, why...

2010-07-01

183

21 CFR 1314.150 - Order To show cause.  

Science.gov (United States)

...2010-04-01 2010-04-01 false Order To show cause. 1314.150 Section 1314.150 Food...OF SCHEDULED LISTED CHEMICAL PRODUCTS Order to Show Cause § 1314.150 Order To show cause. (a) If, upon information...

2010-04-01

184

47 CFR 1.701 - Show cause orders.  

Science.gov (United States)

...2010-10-01 2010-10-01 false Show cause orders. 1.701 Section 1...Common Carriers General § 1.701 Show cause orders. (a) The Commission...by serving upon the carrier an order to show cause. The order shall contain...

2010-10-01

185

41 CFR 60-1.28 - Show cause notices.  

Science.gov (United States)

...2010-07-01 2010-07-01 true Show cause notices. 60-1.28 Section...and Complaint Procedure § 60-1.28 Show cause notices. When the Deputy Assistant...issue a notice requiring the contractor to show cause, within 30 days, why...

2010-07-01

186

21 CFR 1301.37 - Order to show cause.  

Science.gov (United States)

...2010-04-01 2010-04-01 false Order to show cause. 1301.37 Section 1301.37...of Registration § 1301.37 Order to show cause. (a) If, upon examination...shall serve upon the applicant an order to show cause why the registration should not...

2010-04-01

187

41 CFR 60-4.8 - Show cause notice.  

Science.gov (United States)

...2010-07-01 2010-07-01 true Show cause notice. 60-4.8 Section 60-4...CONTRACTORS-AFFIRMATIVE ACTION REQUIREMENTS § 60-4.8 Show cause notice. If an investigation...contractor or subcontractor a notice to show cause which shall contain the items...

2010-07-01

188

18 CFR 808.15 - Show cause proceeding.  

Science.gov (United States)

...2010-04-01 2010-04-01 false Show cause proceeding. 808.15 Section...Compliance and Enforcement § 808.15 Show cause proceeding. (a) The Executive...violator to appear before the Commission and show cause why a penalty should not be...

2010-04-01

189

10 CFR 110.62 - Order to show cause.  

Science.gov (United States)

...2010-01-01 2010-01-01 false Order to show cause. 110.62 Section 110.62...and Enforcement § 110.62 Order to show cause. (a) In response to an alleged...modify a license by issuing an order to show cause: (1) Stating the alleged...

2010-01-01

190

10 CFR 590.401 - Orders to show cause.  

Science.gov (United States)

...2010-01-01 2010-01-01 false Orders to show cause. 590.401 Section 590.401...Opinions and Orders § 590.401 Orders to show cause. A proceeding under this...gas over which FE has jurisdiction. Any show cause order issued shall identify...

2010-01-01

191

14 CFR 314.14 - Show-cause order.  

Science.gov (United States)

...2010-01-01 2010-01-01 false Show-cause order. 314.14 Section 314...of Qualifying Dislocation § 314.14 Show-cause order. When the Department...order will direct all interested persons to show cause why the tentative decision...

2010-01-01

192

29 CFR 34.41 - Notice to Show Cause.  

Science.gov (United States)

...2010-07-01 2010-07-01 true Notice to Show Cause. 34.41 Section 34.41 Labor...Compliance Procedures § 34.41 Notice to Show Cause. (a) The Director may issue a Notice to Show Cause to a recipient failing to...

2010-07-01

193

41 CFR 60-250.64 - Show cause notices.  

Science.gov (United States)

...2010-07-01 2010-07-01 true Show cause notices. 60-250.64 Section...Complaint Procedures § 60-250.64 Show cause notices. When the Deputy Assistant...issue a notice requiring the contractor to show cause, within 30 days, why...

2010-07-01

194

25 CFR 141.56 - Show cause procedures.  

Science.gov (United States)

...2010-04-01 2010-04-01 false Show cause procedures. 141.56 Section...Procedures and Remedies § 141.56 Show cause procedures. (a) When the...the date of receipt of notice in which to show cause why the contemplated remedial...

2010-04-01

195

14 CFR 303.44 - Show cause proceedings.  

Science.gov (United States)

...2010-01-01 2010-01-01 false Show cause proceedings. 303.44 Section...Upon Application or Review § 303.44 Show cause proceedings. If the Assistant...granted application, will be considered in a show cause proceeding, a tentative...

2010-01-01

196

21 CFR 1309.46 - Order to show cause.  

Science.gov (United States)

...2010-04-01 2010-04-01 false Order to show cause. 1309.46 Section 1309.46...of Registration § 1309.46 Order to show cause. (a) If, upon examination...shall serve upon the applicant an order to show cause why the application for...

2010-04-01

197

41 CFR 60-300.64 - Show cause notices.  

Science.gov (United States)

...2010-07-01 2010-07-01 true Show cause notices. 60-300.64 Section...Complaint Procedures § 60-300.64 Show cause notices. When the Deputy Assistant...issue a notice requiring the contractor to show cause, within 30 days, why...

2010-07-01

198

34 CFR 300.193 - Request to show cause.  

Science.gov (United States)

...2010-07-01 2010-07-01 false Request to show cause. 300.193 Section 300.193...Private Schools § 300.193 Request to show cause. An SEA, LEA or other public...300.192 that seeks an opportunity to show cause why a by-pass should not be...

2010-07-01

199

46 CFR 502.66 - Order to show cause.  

Science.gov (United States)

...2010-10-01 2010-10-01 false Order to show cause. 502.66 Section 502.66...Motions; Replies § 502.66 Order to show cause. The Commission may institute a proceeding by order to show cause. The order shall be served upon...

2010-10-01

200

16 CFR 5.57 - Order to show cause.  

Science.gov (United States)

...2010-01-01 2010-01-01 false Order to show cause. 5.57 Section 5.57 Commercial...Conflict of Interest § 5.57 Order to show cause. (a) Upon a Commission...an order requiring the former employee to show cause why sanctions should not be...

2010-01-01

 
 
 
 
201

Otoconia-deficient mice show selective spatial deficits.  

Science.gov (United States)

The vestibular system contributes to the performance of various spatial memory tasks, but few studies have attempted to disambiguate the roles of the semicircular canals and otolith organs in this performance. This study tested the otolithic contribution to spatial working and reference memory by evaluating the performance of otoconia-deficient tilted mice on a radial arm maze and a Barnes maze. One radial arm maze task provided both intramaze and extramaze cues, whereas the other task provided only extramaze cues. The Barnes maze task provided only extramaze cues. On the radial arm maze, tilted mice performed similar to control mice when intramaze cues were available, but committed more working and reference memory errors than control mice when only extramaze cues were available. On the Barnes maze task, control and tilted mice showed similar latency, distance, and errors during acquisition training. On the subsequent probe trial, both groups spent the greatest percentage of time in the goal quadrant, indicating they were able to use extramaze cues to guide their search. Overall, these results suggest signals originating in the otolith organs contribute to spatial memory, but are not necessary for all aspects of spatial performance. © 2014 Wiley Periodicals, Inc. PMID:24802640

Yoder, Ryan M; Kirby, Seth L

2014-10-01

202

Ca (II-EDTA shows antimicrobial activity against periodontopathic bacteria  

Directory of Open Access Journals (Sweden)

Full Text Available Ethylenediamine-N,N,N’,N’-tetraacetic acid calcium (II disodium salt (Ca (II-EDTA was investigated for its antibacterial activity against the periodontal pathogens Aggregatibacter actinomycetemcomitans, Prevotella intermedia and Porphyromonas gingivalis. We determined the minimum inhibitory concentrations (MIC of Ca (II-EDTA and its bactericidal activity. Ethylenediamine-N,N,N’,N’-tetraacetic acid calcium (II disodium salt inhibited the growth of all the periodontopathic bacteria tested in broth. An MIC of 60 mM was the most effective against P. gingivalis. An adenosine triphosphate bioluminescence assay revealed that Ca (II-EDTA showed bactericidal activity against the bacteria tested in a time-dependent manner. To determine its safety in mammalian cells, we investigated the viability of murine L929 cells subjected to Ca (II-EDTA treatment. At 75 mM, 93% ± 0.13% of the cells survived. These results indicate that Ca (II-EDTA is a candidate chelating agent for prevention of infection by periodontopathic bacteria.

Masao Yoshinari

2012-01-01

203

Insertion Sequences show diverse recent activities in Cyanobacteria and Archaea  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract Background Mobile genetic elements (MGEs play an essential role in genome rearrangement and evolution, and are widely used as an important genetic tool. Results In this article, we present genetic maps of recently active Insertion Sequence (IS elements, the simplest form of MGEs, for all sequenced cyanobacteria and archaea, predicted based on the previously identified ~1,500 IS elements. Our predicted IS maps are consistent with the NCBI annotations of the IS elements. By linking the predicted IS elements to various characteristics of the organisms under study and the organism's living conditions, we found that (a the activities of IS elements heavily depend on the environments where the host organisms live; (b the number of recently active IS elements in a genome tends to increase with the genome size; (c the flanking regions of the recently active IS elements are significantly enriched with genes encoding DNA binding factors, transporters and enzymes; and (d IS movements show no tendency to disrupt operonic structures. Conclusion This is the first genome-scale maps of IS elements with detailed structural information on the sequence level. These genetic maps of recently active IS elements and the several interesting observations would help to improve our understanding of how IS elements proliferate and how they are involved in the evolution of the host genomes.

Xu Ying

2008-01-01

204

Preproenkephalin knockout mice show no depression-related phenotype.  

Science.gov (United States)

Clinical, preclinical, and pharmacological studies have suggested that decreased enkephalin tone is associated with depression-like symptoms and increase in enkephalin signaling could have a therapeutic value in the treatment of depression. In this study we demonstrate that, surprisingly, animals lacking enkephalin (preproenkephalin, Penk1(-/-)) showed no depression-related phenotype in the Porsolt forced swimming or tail suspension tests. Moreover, Penk1(-/-) mice had a lower frequency of depression-related behavior in stress-induced hypoactivity and ultrasonic vocalization models of depression, similar to animals treated with antidepressant drugs, although this effect was specific to the genetic background. In addition, there was no significant difference in the efficacy of antidepressant reference compounds in wild-type and knockout animals. Nialamide and amitriptyline were even slightly more effective in animals with genetic deletion of Penk1, whereas the minimal effective dose of imipramine and fluoxetine was the same in the two genotypes. The dual peptidase inhibitor RB-101 was also effective in Penk1(-/-) as well as in Penk1(-/-)/Pdyn(-/-) animals, although its efficacy was somewhat reduced compared with wild-type animals. This result was also surprising because the antidepressant effects of RB-101 were thought to be due to the elevation of enkephalin levels. PMID:17375141

Bilkei-Gorzo, Andras; Michel, Kerstin; Noble, Florence; Roques, Bernard P; Zimmer, Andreas

2007-11-01

205

Multilocus Phylogenetics Show High Intraspecific Variability within Fusarium avenaceum  

Directory of Open Access Journals (Sweden)

Full Text Available Fusarium avenaceum is a common soil saprophyte and plant pathogen of a variety of hosts worldwide. This pathogen is often involved in the crown rot and head blight of cereals that affects grain yield and quality. F. avenaceum contaminates grain with enniatins more than any species, and they are often detected at the highest prevalence among fusarial toxins in certain geographic areas. We studied intraspecific variability of F. avenaceum based on partial sequences of elongation factor-1 alpha, enniatin synthase, intergenic spacer of rDNA, arylamine N-acetyltransferase and RNA polymerase II data sets. The phylogenetic analyses incorporated a collection of 63 F. avenaceum isolates of various origin among which 41 were associated with wheat. Analyses of the multilocus sequence (MLS data indicated a high level of genetic variation within the isolates studied with no significant linkage disequilibrium. Correspondingly, maximum parsimony analyses of both MLS and individual data sets showed lack of clear phylogenetic structure within F. avenaceum in relation to host (wheat and geographic origin. Lack of host specialization indicates no host selective pressure in driving F. avenaceum evolution, while no geographic lineage structure indicates widespread distribution of genotypes that resulted in nullifying the effects of geographic isolation on the evolution of this species. Moreover, significant incongruence between all individual tree topologies and little clonality is consistent with frequent recombination within F. avenaceum.

Tomasz Kulik

2011-08-01

206

1998 results  

International Nuclear Information System (INIS)

This document presents the financial and commercial results of Gaz de France (GdF) company for 1998. The following points are presented successively: financial results (budget results, turnover, self-financing capacity, investments, debt situation), commercial results (some remarkable numbers and records, the tertiary and residential market, the industrial market, cogeneration and natural gas for vehicles), the strategy, 1998 realizations and perspectives (the natural gas energy in the 21. century, the development of GdF, the gas distribution and services (development of the French distribution system, export of the know-how, development of services), the transportation and storage systems threw Europe (densification of the pipeline network, the key-position of France, the north-south equilibrium of the distribution network), the natural gas production by GdF, the diversification of supplies, and the main daughter companies abroad). (J.S.)

207

ATLAS results  

CERN Document Server

We review physics results of the ATLAS experiment at the Large Hadron Collider (LHC) at CERN, based on data collected during 7 TeV and 8 TeV proton-proton collisions, lead-lead collisions at 2.76 TeV and proton-lead collisions at 5.02 TeV center-of-mass energy. This talk presents Standard Model measurements of the W/Z boson and top quark, most recent studies of the Higgs boson and searches for processes beyond Standard Model. Finally, selected heavy ion results from lead-lead and proton-lead collisions are presented.

Stanecka, E; The ATLAS collaboration

2014-01-01

208

Research Results  

Science.gov (United States)

Research on Global Carbon Emission and Sequestration NSFC Funded Project Made Significant Progress in Quantum Dynamics Functional Human Blood Protein Obtained from Rice How Giant Pandas Thrive on a Bamboo Diet New Evidence of Interpersonal Violence from 129,000 Years Ago Found in China Aptamer-Mediated Efficient Capture and Release of T Lymphocytes on Nanostructured Surfaces BGI Study Results on Resequencing 50 Accessions of Rice Cast New Light on Molecular Breeding BGI Reports Study Results on Frequent Mutation of Genes Encoding UMPP Components in Kidney Cancer Research on Habitat Shift Promoting Species Diversification

2011-12-01

209

47 CFR 74.131 - Licensing requirements, necessary showing.  

Science.gov (United States)

... Licensing requirements, necessary showing. 74.131 Section 74.131 Telecommunication FEDERAL COMMUNICATIONS COMMISSION...DISTRIBUTIONAL SERVICES Experimental Broadcast Stations § 74.131 Licensing requirements, necessary...

2010-10-01

210

Extraordinary results  

International Nuclear Information System (INIS)

For the first time in the history, Slovenske elektrarne became the first winner in a new category Business and Biodiversity in the competition of European companies aimed at the environment protection. Excellent results were achieved by a long-term co-operation with the Tatras National Park, in particular in saving the endangered animals.

211

A novel nucleic acid analogue shows strong angiogenic activity  

International Nuclear Information System (INIS)

Research highlights: ? A novel nucleic acid analogue (2Cl-C.OXT-A, m.w. 284) showed angiogenic potency. ? It stimulated the tube formation, proliferation and migration of HUVEC in vitro. ? 2Cl-C.OXT-A induced the activation of ERK1/2 and MEK in HUVEC. ? Angiogenic potency in vivo was confirmed in CAM assay and rabbit cornea assay. ? A synthesized small angiogenic agent would have great clinical therapeutic value. -- Abstract: A novel nucleic acid analogue (2Cl-C.OXT-A) significantly stimulated tube formation of human umbilical endothelial cells (HUVEC). Its maximum potency at 100 ?M was stronger than that of vascular endothelial growth factor (VEGF), a positive control. At this concentration, 2Cl-C.OXT-A moderately stimulated proliferation as well as migration of HUVEC. To gain mechanistic insights how 2Cl-C.OXT-A promotes angiogenic responses in HUVEC, we performed immunoblot analyses using phospho-specific antibodies as probes. 2Cl-C.OXT-A induced robust phosphorylation/activation of MAP kinase ERK1/2 and an upstream MAP kinase kinase MEK. Conversely, a MEK inhibitor PD98059 abolished ERK1/2 activation and tube formation both enhanced by 2Cl-C.OXT-A. In contrast, MAP kinase responses elicited by 2Cl-C.OXT-A were not inhibited by SU5416, a specific inhibitor of VEGF receptor tyrosine kinase. Collectively these results suggest that 2Cl-C.OXT-A-induces angiogenic responses in HUVEC mediated by a MAP kinase cascade comprising MEK and ERK1/2, but independently of VEGF receptor tyrosine kinase. In vivo assay using chicken chorioallantoic membrane (CAM) and rabbit cornea also suggested the angiogenic potency of 2Cl-C.OXT-A.

212

The Daily Show with Jon Stewart: Part 2  

Science.gov (United States)

"The Daily Show With Jon Stewart" is one of the best critical literacy programs on television, and in this Media Literacy column the author suggests ways that teachers can use video clips from the show in their classrooms. (For Part 1, see EJ784683.)

Trier, James

2008-01-01

213

"The Daily Show with Jon Stewart": Part 1  

Science.gov (United States)

Comedy Central's popular program "The Daily Show With Jon Stewart" is the best critical media literacy program on television, and it can be used in valuable ways in the classroom as part of a media literacy pedagogy. This Media Literacy column provides an overview of the show and its accompanying website and considers ways it might be used in the…

Trier, James

2008-01-01

214

Landsat 7 Images Show Scale of Tsunami Damage  

Science.gov (United States)

This NASA page shows before and after pictures taken by Landsat 7's Enhanced Thematic Mapper Plus (ETM+) instrument of a part of the coast of Sumatra, Indonesia. The images show that the scale of the tsunami's impact can be seen from space.

Nasa

215

47 CFR 73.33 - Antenna systems; showing required.  

Science.gov (United States)

...2010-10-01 2010-10-01 false Antenna systems; showing required. 73.33... AM Broadcast Stations § 73.33 Antenna systems; showing required. (a...application for authority to install a broadcast antenna shall specify a definite site and...

2010-10-01

216

ShowFlow: A practical interface for groundwater modeling  

Energy Technology Data Exchange (ETDEWEB)

ShowFlow was created to provide a user-friendly, intuitive environment for researchers and students who use computer modeling software. What traditionally has been a workplace available only to those familiar with command-line based computer systems is now within reach of almost anyone interested in the subject of modeling. In the case of this edition of ShowFlow, the user can easily experiment with simulations using the steady state gaussian plume groundwater pollutant transport model SSGPLUME, though ShowFlow can be rewritten to provide a similar interface for any computer model. Included in this thesis is all the source code for both the ShowFlow application for Microsoft{reg sign} Windows{trademark} and the SSGPLUME model, a User's Guide, and a Developer's Guide for converting ShowFlow to run other model programs. 18 refs., 13 figs.

Tauxe, J.D.

1990-12-01

217

Amanda results  

CERN Document Server

The AMANDA (Antarctic Muon And Neutrino Detector Array) detector, located at the South Pole station, Antarctica, was recently expanded with the addition of six new strings, completing the phase referred to as AMANDA-II. This detector has been calibrated and in operation since January 2000. The first data analyses are currently underway. In this report we present an update on the results from the AMANDA-B10 detector, which operated during the austral winter 1997.

Hill, G C

2001-01-01

218

Reki-Show Authoring Tools : Risk, Space and History  

Directory of Open Access Journals (Sweden)

Full Text Available In social sciences, most events occur in specific time and space. We call such events here "Spatiotemporal Events". It is obvious that events, having always a beginning and an end, appear at a specific place or in particular space. Suppose there exists an conceptual data model regulating some rules to describe those factors, it enables us to store various spatiotemporal events as data and to refer with one another. We, therefore, define a simple spatiotemporal data model, calling "Reki-Show". We also call the information system, consisting of Reki-Show data model, "Reki-Show System", and consider Reki-Show System as the basic information system to deal with the various events in human society. Accordingly, we have recognized that it is indispensable in the future social sciences to have the database and tool for both the temporal and spatial attributes, and have been developing Reki-Show Authoring Tools based on the conceptual framework in Reki-Show System. At present, the fundamental component has been developed already through some steps, and the system is now applied to the empirical research. We would like to make a report of the outline at this stage. This paper explains the basic concept in Reki-Show (Conseptual Data Modeling, followed by the outline of the implemented system.

Makoto Hanashima

2005-12-01

219

Map showing locations of damaging landslides in Sonoma County, California, resulting from 1997-98 El Nino rainstorms  

Science.gov (United States)

Heavy rainfall associated with a strong El Nino caused over $150 million in landslide damage in the 10-county San Francisco Bay region during the winter and spring of 1998. A team of USGS scientists collected information on landslide locations and damage costs. About $21 million in damages were assessed in Sonoma County.

Ramsey, David W.; Godt, Jonathan W.

1999-01-01

220

Novel Ebola Vaccine Shows Potential in Monkey Trial  

Science.gov (United States)

... features on this page, please enable JavaScript. Novel Ebola Vaccine Shows Potential in Monkey Trial Findings prompted ... 2014) Monday, September 8, 2014 Related MedlinePlus Pages Ebola Immunization SUNDAY, Sept. 7, 2014 (HealthDay News) -- An ...

 
 
 
 
221

??????????????---?????? Computer Simulation, a Nice Case —Now We Can Show  

Directory of Open Access Journals (Sweden)

Full Text Available ????????????????????????????????????????????????????????[1]????????????????????????????????????????????????“????”???This paper shows a case of computer simulation in China’s aerospace industry, which combines mathematics, physics, astronomy, electricity and manufacture[1]. This is a nice case and gives us some nice experiences for future.

???

2013-04-01

222

Single-Dose, Injected Flu Treatment Shows Promise  

Science.gov (United States)

... sharing features on this page, please enable JavaScript. Single-Dose, Injected Flu Treatment Shows Promise Two studies ... SATURDAY, Sept. 6, 2014 (HealthDay News) -- A new single-dose, injected drug appears safe and effective at ...

223

Housekeeping genes tend to show reduced upstream sequence conservation  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Mammalian housekeeping genes show significantly lower promoter sequence conservation, especially upstream of position -500 with respect to the transcription start site, than genes expressed in a subset of tissues.

Farre?, Dome?nec; Bellora, Nicola?s; Mularoni, Loris; Messeguer, Xavier; Alba?, M. Mar

2007-01-01

224

47 CFR 73.24 - Broadcast facilities; showing required.  

Science.gov (United States)

... 2010-10-01 2010-10-01 false Broadcast facilities; showing required. 73.24 ...FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) BROADCAST RADIO SERVICES RADIO BROADCAST SERVICES AM Broadcast Stations §...

2010-10-01

225

Research Shows No Link Between Vaccinations, Risk for Multiple Sclerosis  

Science.gov (United States)

... Research Shows No Link Between Vaccinations, Risk for Multiple Sclerosis Large study finds no association, although certain shots ... Tuesday, October 21, 2014 Related MedlinePlus Pages Immunization Multiple Sclerosis TUESDAY, Oct. 21, 2014 (HealthDay News) -- A new ...

226

Latin America Shows Rapid Rise in S&E Articles  

Science.gov (United States)

... August 2004 PDF format | See Related Reports Latin America Shows Rapid Rise in S&E Articles by ... engineering (S&E) articles credited to Latin American institutional authors and published in a set ...

227

Salivary Gland Biopsy Shows Promise to Helping to Diagnose Parkinson's  

Science.gov (United States)

Parkinson's HelpLine Learn More Educational Materials Do you want to know more about Parkinson's? PDF's materials provide ... Gland Biopsy Shows Promise to Helping to Diagnose Parkinson’s - Mar 20 2014 A simple outpatient procedure that ...

228

Obesity Tied to Half a Million Cancers Worldwide, Report Shows  

Science.gov (United States)

... sharing features on this page, please enable JavaScript. Obesity Tied to Half a Million Cancers Worldwide, Report Shows Largest number of obesity-related cancers diagnosed in North America and Europe, ...

229

41 CFR 60-300.64 - Show cause notices.  

Science.gov (United States)

...2010-07-01 true Show cause notices. 60-300.64 Section 60-300.64 Public Contracts and Property Management ...EQUAL EMPLOYMENT OPPORTUNITY, DEPARTMENT OF LABOR 300-AFFIRMATIVE ACTION AND NONDISCRIMINATION...

2010-07-01

230

Vaccine Shows Promise Against Mosquito-Borne Virus  

Science.gov (United States)

... enable JavaScript. Vaccine Shows Promise Against Mosquito-Borne Virus Volunteers developed antibodies to chikungunya in first human ... to protect people from the mosquito-borne chikungunya virus has shown promise in its first human trial. " ...

231

Pedagogy of the Talk Show Hosts and Hostesses.  

Science.gov (United States)

Explores the apparently disparate link between successfully hosting a talk show and successfully teaching a college class and describes methods this professor has used to foster class discussion and student interest. (EV)

Heinze, Denise

2001-01-01

232

When Should Zero Be Included on a Scale Showing Magnitude?  

Science.gov (United States)

This article addresses an important problem of graphing quantitative data: should one include zero on the scale showing magnitude? Based on a real time series example, the problem is discussed and some recommendations are proposed.

Kozak, Marcin

2011-01-01

233

Family Acceptance Key to Curbing Teen Suicides, Study Shows  

Science.gov (United States)

... please enable JavaScript. Family Acceptance Key to Curbing Teen Suicides, Study Shows Validation by peers also decreased ... October 17, 2014 Related MedlinePlus Pages Parenting Suicide Teen Mental Health FRIDAY, Oct. 17, 2014 (HealthDay News) -- ...

234

Simple pneumonediastinum showing the findings of pleural effusion  

International Nuclear Information System (INIS)

We experienced a case of simple pneumonediastinum showing the findings of pleural effusion. Frontal chest radiography showed not only pneumonediastinum but also diffuse haziness with sharp medical margin on left lower lung field, blunting of costophrenic angle, and indistinct contour of diaphragm simulating pleural effusion. CT scan confirmed that these findings arose from the displaced pleura and the associated compression atelectasis by loculated air on the anterior mediastinum

235

Effective Marketing Strategies to Attract Business Visitors at Trade Shows  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Trade shows have been the focus of recent research as constituting one of the most effective marketing strategies.Related issues have been discussed extensively in the literature. How to achieve better performance is central tothese discussions. Studies on the key factors that influence trade show performance have focused mainly onsubjective opinions from the perspective of the staff at exhibitions. In this study, we explored the key criteria fora business visitor in selecting suppliers at...

Mei-Chin Chu; Sui-Ming Chiu

2013-01-01

236

An induced sterile mutant in black gram (Vigna mungo L.) showing failure of chromosome pairing  

International Nuclear Information System (INIS)

In a M2 progeny row of black gram var. T9, resulting from irradiation treatment, a plant was recorded which showed considerable univalent formation. The M2 progeny confirmed its generic nature, showing its possible monogenetic control. (auth.)

237

Grab That Mike: communicative issues in French Talk Show "Grab That Mike": questões comunicativas em um "Talk Show" Francês  

Directory of Open Access Journals (Sweden)

Full Text Available In this analysis we have chosen a recent French talk show to illustrate how communication is turned into some new kind of "ideology"nowadays: in other words, you have to communicate if you consider yourself a citizen of today's world. The main characteristic of issue-centered talk shows being the destabilization of the implicit rules and participation framework, we observe how the so-called democratic right to express ourselves is (misused by the talk show host to secure the dynamics of the show. In order to reveal the host's manipulations, we have examined the verbal interactions between host and guests on the following issues: topic choice, turn-taking mechanisms and identity construction of the talk show's guests. In the perspective that this kind of talk show presents itself as a public space where direct democracy can be exercised, the analysis of the discursive strategies of the talk show host reveals the impact of a mediatic participation framework.Para a presente análise escolhemos um "talk show" francês recente para ilustrar como a comunicação se transforma em um novo tipo de ideologia: em outras palavras, você deve se comunicar se você se considera um cidadão do mundo de hoje. Sendo a principal característica do talk show a desestabilização das regras implícitas e o framework de participação, observamos como o tal direito democrático de expressão é interpretado pelo apresentador para manter a dinâmica do programa. Para revelar suas manipulações, examinamos as interações verbais entre apresentador e convidados nos seguintes temas: escolha do tópico, mecanismos de tomada de turno e construção de identidade dos convidados. É nessa perspectiva que este tipo de programa se apresenta como um espaço público onde a democracia direta pode ser exercitada; a análise das estratégias discursivas do apresentador do talk show revela o impacto de um framework de participação mediada.

Ludwina Van Son

2004-12-01

238

Material properties characterization of low carbon steel using TBW and PWHT techniques in smooth-contoured and U-shaped geometries  

International Nuclear Information System (INIS)

This paper investigates the effects of the temper bead welding (TBW) technique and post weld heat treatment (PWHT) on mechanical properties of multi-layer welding on low carbon steel specimens using Charpy V-notch impact testing and tensile testing. Several samples of two different weld geometries, viz. (i) smooth-contoured, and (ii) U-shaped were made with multiple bead layers using both TBW and PWHT techniques. Impact testing showed that at room temperature and below, TBW gave an impact toughness in the Heat Affected Zone (HAZ) better than both PWHT and the parent material. At temperatures higher than the room temperature but below 60 °C, PWHT gave better impact toughness in the HAZ. Above 60 °C, both TBW and PWHT showed impact toughness lower than that of the parent material. In tensile testing, both TBW and PWHT weld metal specimens produced acceptable results; however, TBW gave yield and tensile strengths closer to that of the actual material than PWHT. -- Highlights: • Effects of post weld heat treatment (PWHT) and temper bead welding (TBW) on properties are tested. • Charpy V-notch impact and tensile testing was performed on multi-layer welding of low carbon steel. • At room temperature and below, TBW gave better impact toughness than both PWHT and parent material. • Above room temperature but below 60 °C, PWHT gave better impact toughness than TBW. • Above 60 °C, both TBW and PWHT showed impact toughness lower than that of parent material

239

Optimizing the Natural Frequencies of Beams via Notch Stamping  

Directory of Open Access Journals (Sweden)

Full Text Available Natural frequency optimization is important to avoid the coincidence of excitation frequency and natural frequency which causes resonance phenomenon. In this study, the natural frequencies of a beam, with different boundary conditions, are enhanced by stamping V-notches on its surface. These notches alter the local stiffness in the beam while keeping the mass the same. This method is cost-effective in comparison with other Structural Dynamics Modification methods (SDM because it is a one-step manufacturing method and because it enhances the dynamic behavior of beam structures without additional weight or additional joints. The natural frequencies of notched beam are calculated by finite element method. In particular, ANSYS package is used in building the notched beam models for modal analysis. The effect of notch location and size on the beam fundamental frequency is investigated. The simulation results indicated that creating notches on free-free beam decreases its fundamental frequency, while creating notches on clamped beam may increase its fundamental frequency. The optimal designs of notched beams are presented. The proposed method couples a finite element method for the modal analysis with an optimization technique based on Genetic Algorithm (GA. Three examples are presented to show the optimal design of free-free and clamped notched beams. The optimization results show that V-notch stamping technique is an effective technique to optimize the natural frequencies.

Nabeel T. Alshabatat

2012-07-01

240

Five Kepler target stars that show multiple transiting exoplanet candidates  

CERN Document Server

We present and discuss five candidate exoplanetary systems identified with the Kepler spacecraft. These five systems show transits from multiple exoplanet candidates. Should these objects prove to be planetary in nature, then these five systems open new opportunities for the field of exoplanets and provide new insights into the formation and dynamical evolution of planetary systems. We discuss the methods used to identify multiple transiting objects from the Kepler photometry as well as the false-positive rejection methods that have been applied to these data. One system shows transits from three distinct objects while the remaining four systems show transits from two objects. Three systems have planet candidates that are near mean motion commensurabilities - two near 2:1 and one just outside 5:2. We discuss the implications that multitransiting systems have on the distribution of orbital inclinations in planetary systems, and hence their dynamical histories; as well as their likely masses and chemical compos...

Steffen, Jason H; Borucki, William J; Buchhave, Lars A; Caldwell, Douglas A; Cochran, William D; Endl, Michael; Fabrycky, Daniel C; Fressin, François; Ford, Eric B; Fortney, Jonathan J; Haas, Michael J; Holman, Matthew J; Isaacson, Howard; Jenkins, Jon M; Koch, David; Latham, David W; Lissauer, Jack J; Moorhead, Althea V; Morehead, Robert C; Marcy, Geoffrey; MacQueen, Phillip J; Quinn, Samuel N; Ragozzine, Darin; Rowe, Jason F; Sasselov, Dimitar D; Seager, Sara; Torres, Guillermo; Welsh, William F

2010-01-01

 
 
 
 
241

Uni Dufour | Ig Nobel Show with Marc Abrahams | 7 May  

CERN Multimedia

On 7 May, Marc Abrahams, founder of the Ig Nobel Prize, will give an "Ig Nobel show", in English at Uni Dufour. The Ig Nobel Prizes are an American parody of the Nobel Prizes. In early October of each year, they are awarded to ten unusual or trivial achievements in scientific research. The stated aim of the prizes is to "first make people laugh, and then make them think". Marc Abrahams will introduce this funny and dynamic evening with a short presentation before handing over to a selection of recipients. The show is free and open to all. Tuesday 7 May Ig Nobel Show 6:30 p.m. - Room U600 Uni Dufour

2013-01-01

242

Vegetation Images Show Drought in Western US (WMS)  

Science.gov (United States)

Satellite data can gauge the health of plants, which is a good indicator of drought. The Normalized Difference Vegetation Index (NDVI) measures how dense and green plant leaves are. NDVI images are useful as a measure of drought when compared to "normal" plant health. Scientists calculate average NDVI values for an area to find out what is normal at a particular time of year. This animation uses satellite imagery to show changes in vegetation between 1999 and 2003. In 2002, drought had settled across the Midwest. Large dark brown sections of eastern Colorado show where vegetation was less lush and healthy than normal. This version of the visualization is a wide view showing the western United States. The data were measured by the vegetation instrument on Europes SPOT-4 satellite, and were provided by DigitalGlobe-SPOT under agreement with the U.S. Department of Agriculture Foreign Agricultural Service (USDA-FAS).

Delabeaujardiere, Jeff; Shirah, Greg; Mitchell, Horace; Anyamba, Asaph

2005-02-16

243

The Physics Circus -- Engaging students through a demo show  

Science.gov (United States)

The Physics Circus is a fun and exciting demo show presented by the UT Austin Physics Department at elementary, middle, and high schools in central Texas with the aim of engaging students. I will discuss the goals of this program, its facilitation, and the impact it has on the students who see the presentation as well as the university students who actively do the demonstrations. I will also demonstrate some highlights from the show, including the electric pickle, the flaming dollar, and the exploding trash can.

Hinko, Kathleen

2010-03-01

244

CERN cars drive by the Geneva Motor Show  

CERN Multimedia

One of CERN's new gas-fuelled cars was a special guest at the press days of the Geneva motor show this year. The car enjoyed a prominent position on the Gazmobil stand, right next to the latest Mazeratis and Ferraris. Journalists previewing the motor show could discover CERN's support for green technologies and also find out more about the lab - home to the fastest racetrack on the planet, with protons in the LHC running at 99.9999991% of the speed of light.    

CERN Bulletin

2011-01-01

245

An Analysis of Conversation Structure In Ellen Show  

Directory of Open Access Journals (Sweden)

Full Text Available The conversation analysis theory is applied to analyze the structure and organization of human oral conversation. This paper attempts to apply conversation analysis theory to analyze conversation structure features of Ellen Show from two aspects: global structure and local structure. The features of global structure are analyzed from opening, body and closing process. As to local structure, features in turn-taking strategies, adjacency pairs and feedback are analyzed. The study can help appreciate Ellen Show and contribute to developing people’s communication skills and enhancing their discourse competence.

Rui KONG

2014-10-01

246

Ohio State study shows how chronic inflammation can cause leukemia  

Science.gov (United States)

A hormone-like substance produced by the body to promote inflammation can cause an aggressive form of leukemia when present at high levels, according to a new study by researchers at the Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute. The study shows that high levels of interleukin-15 (IL-15) alone can cause large granular lymphocytic (LGL) leukemia, a rare and usually fatal form of cancer, in an animal model. The researchers also developed a treatment for the leukemia that showed no discernible side effects in the animal model.

247

Teaching Job Interviewing Skills with the Help of Television Shows  

Science.gov (United States)

Because of its potential for humor and drama, job interviewing is frequently portrayed on television. This article discusses how scenes from popular television series such as "Everybody Loves Raymond," "Friends," and "The Mary Tyler Moore Show" can be used to teach effective job interview skills in business communication courses. Television…

Bloch, Janel

2011-01-01

248

Embryonic Stem Cell Therapy Shows Long-Term Effectiveness, Safety  

Science.gov (United States)

... features on this page, please enable JavaScript. Embryonic Stem Cell Therapy Shows Long-Term Effectiveness, Safety In small ... October 15, 2014 Related MedlinePlus Pages Macular Degeneration Stem Cells TUESDAY, Oct. 14, 2014 (HealthDay News) -- A new ...

249

"Country Life"? Rurality, Folk Music and "Show of Hands"  

Science.gov (United States)

This paper examines the contribution of folk music to understanding the dynamic, fluid and multi-experiential nature of the countryside. Drawing from literature on the geographies of music, it examines the work of "Show of Hands", a contemporary folk band from Devon in England. Three areas are studied. First, the paper examines the musical style…

Yarwood, Richard; Charlton, Clive

2009-01-01

250

An autopsied case of tuberculous meningitis showing interesting CT findings  

International Nuclear Information System (INIS)

A 61-year-old female patient died of a neurological disorder of unknown origin one month after the first visit and was found to have had tuberculous meningitis at autopsy. CT revealed a low density area showing an enlargement of the cerebral ventricle but did not reveal contrast enhancement in the basal cistern peculiar to tuberculous meningitis. (Namekawa, K.)

251

Daily Aspirin May Help Prevent Cancer, Study Shows  

Science.gov (United States)

... features on this page, please enable JavaScript. Daily Aspirin May Help Prevent Cancer, Study Shows Taking low-dose pill each day ... studies reviewed for this report don't prove aspirin prevents cancer, they offer strong evidence that it might, Lichtenfeld ...

252

KGB- agents (Part 2: Music and show -bussines)  

Science.gov (United States)

The paper represents a continuation of the previous one 2008stuk.rept.....G and reffers to activity of KGB in the Show Busyness in the former USSR. During 1970-th the activity of KGB was concerned to control the market of musical disks, the disco clubs, the programs and the personal componence of the musical groups and orchestra.

Gaina, Alex

2008-10-01

253

Official showguide of the Lloydminster heavy oil show  

International Nuclear Information System (INIS)

An alphabetical listing of all exhibitors at the Lloydminster heavy oil show was presented. More than 200 companies with direct involvement in heavy oil production are included in the Guide. The listing provides the company name, address, phone number, fax number, and booth location. A brief description of the product or service offered is also included, along with the name of a contact person

254

CMA Member Survey: Network Management Systems Showing Little Improvement.  

Science.gov (United States)

Discusses results of a survey of 112 network and telecom managers--members of the Communications Managers Association (CMA)--to identify problems relating to the operation of large enterprise networks. Results are presented in a table under categories of: respondent profile; network management systems; carrier management; enterprise management;…

Lusa, John M.

1998-01-01

255

New Inspiring Planetarium Show Introduces ALMA to the Public  

Science.gov (United States)

As part of a wide range of education and public outreach activities for the International Year of Astronomy 2009 (IYA2009), ESO, together with the Association of French Language Planetariums (APLF), has produced a 30-minute planetarium show, In Search of our Cosmic Origins. It is centred on the global ground-based astronomical Atacama Large Millimeter/submillimeter Array (ALMA) project and represents a unique chance for planetariums to be associated with the IYA2009. ESO PR Photo 09a/09 Logo of the ALMA Planetarium Show ESO PR Photo 09b/09 Galileo's first observations with a telescope ESO PR Photo 09c/09 The ALMA Observatory ESO PR Photo 09d/09 The Milky Way band ESO PR Video 09a/09 Trailer in English ALMA is the leading telescope for observing the cool Universe -- the relic radiation of the Big Bang, and the molecular gas and dust that constitute the building blocks of stars, planetary systems, galaxies and life itself. It is currently being built in the extremely arid environment of the Chajnantor plateau, at 5000 metres altitude in the Chilean Andes, and will start scientific observations around 2011. ALMA, the largest current astronomical project, is a revolutionary telescope, comprising a state-of-the-art array of 66 giant 12-metre and 7-metre diameter antennas observing at millimetre and submillimetre wavelengths. In Search of our Cosmic Origins highlights the unprecedented window on the Universe that this facility will open for astronomers. "The show gives viewers a fascinating tour of the highest observatory on Earth, and takes them from there out into our Milky Way, and beyond," says Douglas Pierce-Price, the ALMA Public Information Officer at ESO. Edited by world fulldome experts Mirage3D, the emphasis of the new planetarium show is on the incomparable scientific adventure of the ALMA project. A young female astronomer guides the audience through a story that includes unique animations and footage, leading the viewer from the first observations by Galileo, 400 years ago, to the world of modern astronomy, moving from the visible wavelength domain to explore the millimetre-wave view of the Universe, and leaving light-polluted cities for unique settings in some of the highest and driest places on Earth. "The fascinating topic, the breathtaking ESO astronomical images, the amazing 3D computer animations, and the very clever use of the music, all make this a really inspiring show," says Agnès Acker, President of the APLF. In search of our Cosmic Origins is available in three different formats: fulldome video, classical with video windows, and classical with slides. Fulldome video shows immerse the audience in a true 360-degree projected computer-generated virtual environment. The ALMA planetarium show is currently available in French and English. Several other language versions are in preparation: German, Italian, Spanish and Chilean Spanish, while further languages are planned: Danish, Dutch, Greek, Japanese, Portuguese and Brazilian Portuguese. The show will be available to all planetariums worldwide for a small fee, depending on the type and the size of the planetarium, to cover basic costs. The media are invited to attend, and see firsthand, the official screening during the European Film Festival, between 24 and 26 April 2009 in Espinho, Portugal. For media accreditation, please go to http://iff.multimeios.pt/index.php?option=com_wrapper&Itemid=45 A set of educational materials is also being prepared and will be finished in late April. To learn more about the show, please go to www.cosmicorigins.org

2009-03-01

256

Cambrian stalked echinoderms show unexpected plasticity of arm construction.  

Science.gov (United States)

Feeding arms carrying coelomic extensions of the theca are thought to be unique to crinoids among stemmed echinoderms. However, a new two-armed echinoderm from the earliest Middle Cambrian of Spain displays a highly unexpected morphology. X-ray microtomographic analysis of its arms shows they are polyplated in their proximal part with a dorsal series of uniserial elements enclosing a large coelomic lumen. Distally, the arm transforms into the more standard biserial structure of a blastozoan brachiole. Phylogenetic analysis demonstrates that this taxon lies basal to rhombiferans as sister-group to pleurocystitid and glyptocystitid blastozoans, drawing those clades deep into the Cambrian. We demonstrate that Cambrian echinoderms show surprising variability in the way their appendages are constructed, and that the appendages of at least some blastozoans arose as direct outgrowths of the body in much the same way as the arms of crinoids. PMID:21653588

Zamora, S; Smith, A B

2012-01-22

257

[A system for capturing and showing micrographs of genetics experiments].  

Science.gov (United States)

A system for capturing and showing micrographs of genetics was designed with Microsoft Visual Basic 6.0. The system includes many functions such as capturing and editing images, typing and editing text, teaching experiments, showing images, image retrieval, database management, system maintenance and help, all of them were developed with the form of Windows. The system could collect images not only from image-grabber card in real-time but also from scanner, digital camera, clipboard and files. After utilizing the image compression technology, the images will be saved in database along with experiment instruction. With all the features referred above, the system can be used as a wonderful assistant both for the teaching of genetics experiments and for the students' learning by themselves. PMID:15640051

Li, Jian; Pan, Shen-Yuan; Zhu, Ming-Li; Gao, Tian-Hui; Liang, Qing-Shan; Liu, Hong-Xia

2004-07-01

258

Cambrian stalked echinoderms show unexpected plasticity of arm construction  

Science.gov (United States)

Feeding arms carrying coelomic extensions of the theca are thought to be unique to crinoids among stemmed echinoderms. However, a new two-armed echinoderm from the earliest Middle Cambrian of Spain displays a highly unexpected morphology. X-ray microtomographic analysis of its arms shows they are polyplated in their proximal part with a dorsal series of uniserial elements enclosing a large coelomic lumen. Distally, the arm transforms into the more standard biserial structure of a blastozoan brachiole. Phylogenetic analysis demonstrates that this taxon lies basal to rhombiferans as sister-group to pleurocystitid and glyptocystitid blastozoans, drawing those clades deep into the Cambrian. We demonstrate that Cambrian echinoderms show surprising variability in the way their appendages are constructed, and that the appendages of at least some blastozoans arose as direct outgrowths of the body in much the same way as the arms of crinoids. PMID:21653588

Zamora, S.; Smith, A. B.

2012-01-01

259

Network Affordances: Unpredictable parameters of a Hong Kong SPEED SHOW  

DEFF Research Database (Denmark)

This paper examines the notion of network affordance within the context of network art. Building on Gibson's theory (Gibson, 1979) we understand affordance as the perceived and actual parameters of a thing. We expand on Gaver's affordance of predictability (Gaver, 1996) to include ecological and computational parameters of unpredictability. We illustrate the notion of unpredictability by considering four specific works that were included in a network art exhibiton, SPEED SHOW [2.0] Hong Kong. The paper discusses how the artworks are contingent upon the parameteric relations (Parisi, 2013), of the network. We introduce network affordance as a dynamic framework that could articulate the experienced tension arising from the (visible) symbolic representation of computational processes and its hidden occurrences. We base our proposal on the experience of both organising the SPEED SHOW and participating in it as artists, and what we perceived as the lack of concepts available to express how the works modulated thespace and the experience of the network.

Samson, Audrey; Soon, Winnie

2014-01-01

260

Pathway Analysis Shows Association between FGFBP1 and Hypertension  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Variants in the gene encoding fibroblast growth factor 1 (FGF1) co-segregate with familial susceptibility to hypertension, and glomerular upregulation of FGF1 associates with hypertension. To investigate whether variants in other members of the FGF signaling pathway may also associate with hypertension, we genotyped 629 subjects from 207 Polish families with hypertension for 79 single nucleotide polymorphisms in eight genes of this network. Family-based analysis showed that parents transmitte...

Tomaszewski, Maciej; Charchar, Fadi J.; Nelson, Christopher P.; Barnes, Timothy; Denniff, Matthew; Kaiser, Michael; Debiec, Radoslaw; Christofidou, Paraskevi; Rafelt, Suzanne; Harst, Pim; Wang, William Y. S.; Maric, Christine; Zukowska-szczechowska, Ewa; Samani, Nilesh J.

2011-01-01

 
 
 
 
261

The Effectiveness of Trade Shows in Global Competition  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Trade shows industry has experienced a rapid growth during the last years. They are considered as a vital communication technique especially for those companies that operate in international markets and that aim to reach specific audiences. Making them an integral part of the marketing communication strategy enables companies in: developing customer relationships; offering possibilities for sales and sales promotion; undertaking and maintaining good international business relations; monitorin...

JONIDA KELLEZI

2013-01-01

262

The AIDS prevention magic show: avoiding the tragic with magic.  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Teenagers are a crucial target group for interventions concerning acquired immunodeficiency syndrome (AIDS) and human immunodeficiency virus (HIV). Experimenting with their burgeoning sexuality and increased ability to obtain drugs, they are prime candidates for AIDS prevention and education strategies. The intervention described in this paper is a 30-minute magic show, presented by Cyrus (or Iris) the Virus, a sinister but entertaining character portrayed by any health educator willing to sp...

Lustig, S. L.

1994-01-01

263

Controlling mercury: US plants show bromine is the key  

Energy Technology Data Exchange (ETDEWEB)

A new approach to mercury control based on the use of bromine additives is showing promise. It is based on the idea, first put forward by Prof. Bernhard Vosteen that the critical species for the halogenation of mercury is not chlorine but rather bromine. Alstom has acquired the rights from Vosteen Consulting of Germany to market the technology to the power generation industry in the United States and Canada. 3 figs.

Black, S. [Alstom, Knoxville (United States)

2006-06-15

264

PC code STAR. Show transmutation of actinides in reactors  

International Nuclear Information System (INIS)

A program is made named STAR (acronym for Show Transmutation of Actinides in Reactors), which solves analytically the differential equations describing buildup and removal (by decay and transmutation) of nuclides irradiated in a constant neutron flux. The model and algorithm according to which STAR solves the differential equations are explained. Also a short description of the data library is given. STAR is validated with the ORIGEN-S fuel depletion code and runs on IBM compatible PCs and DEC alpha workstations. (orig.)

265

Oil price shows Janus face of the Western world  

International Nuclear Information System (INIS)

The large fluctuations in the oil price have made Europe and the United States think. If nothing changes, there will be much turbulence in the international oil market in the coming decades. International conflicts are lurking. The US is seeking solutions in a larger degree of independence from the Middle East and Venezuela. Europe is seeking more cooperation with the OPEC, aiming at more mutual certainties. The westerns world is thus showing two faces. [mk

266

Data from the Television Game Show "Friend or Foe?"  

Science.gov (United States)

This article, created by David Kalist of Shippensburg University, describes data from the television game show "Friend or Foe." The data can be used to determine factors affecting contestants' strategies using descriptive statistics, testing for differences in means or proportions, and regression analysis. Some of the factor that the author tests for are whether age, gender, race or the amount of prize money affect a contestants decision.

Kalist, David

2009-02-13

267

Assessment of the effects of neutron fluence on Swedish nuclear pressure vessels  

International Nuclear Information System (INIS)

Nuclear pressure vessels are subject to neutron irradiation during service causing embrittlement. This is one important factor in the overall problem of reactor vessel integrity. At present the irradiation effects are mainly assessed by the Charpy V-notch test. Two measures of embrittlement are defined: the increase of the ductile/brittle transition temperature and the decrease in the upper-shelf energy. The object of the present work is to assess these changes for the Swedish nuclear pressure vessels. On the basis of data from irradiations carried out in other countries and Swedish surveillance programmes, the expected end of life embrittlement is estimated for Swedish vessels. The results show that the embrittlement of most reactor vessels is expected to be quite small. Oskarshamn 1 and PWR-vessels, however, will probably show moderate changes, the former due to the higher copper content, and the latter due to the high end of life fluences. Some of the vessel materials which exhibit marginal properties in the upper-shelf energy, as measured by the Charpy V-notch impact test, are identified. It is recommended that fracture mechanics analyses be applied in these cases. (author)

268

Assessment of the effects of neutron fluence on Swedish nuclear pressure vessels  

International Nuclear Information System (INIS)

Nuclear pressure vessels are subject to neutron irradiation during service causing embrittlement. At present the irradiation effects are mainly assessed by the Charpy V-notch test. Two measures of embrittlement are defined: the increase of the ductile/brittle transition temperature and the decrease in the upper-shelf energy. The object of the present work is to assess these changes for the Swedish nuclear pressure vessels. On the basis of data from irradiations carried out in other countries and Swedish surveillance programmes, the expected end of life embrittlement is estimated for Swedish vessels. The results show that the embrittlement of most reactor vessels is expected to be quite small. Oskarshamn 1 and PWR-vessels, however, will probably show moderate changes, the former due to the higher copper content, and the latter due to the high end of life fluences. Some of the vessel materials which exhibit marginal properties in the upper-shelf energy, as measured by the Charpy V-notch impact test, are identified. It is recommended that fracture mechanics analyses be applied in these cases. (author)

269

FIVE KEPLER TARGET STARS THAT SHOW MULTIPLE TRANSITING EXOPLANET CANDIDATES  

International Nuclear Information System (INIS)

We present and discuss five candidate exoplanetary systems identified with the Kepler spacecraft. These five systems show transits from multiple exoplanet candidates. Should these objects prove to be planetary in nature, then these five systems open new opportunities for the field of exoplanets and provide new insights into the formation and dynamical evolution of planetary systems. We discuss the methods used to identify multiple transiting objects from the Kepler photometry as well as the false-positive rejection methods that have been applied to these data. One system shows transits from three distinct objects while the remaining four systems show transits from two objects. Three systems have planet candidates that are near mean motion commensurabilities-two near 2:1 and one just outside 5:2. We discuss the implications that multi-transiting systems have on the distribution of orbital inclinations in planetary systems, and hence their dynamical histories, as well as their likely masses and chemical compositions. A Monte Carlo study indicates that, with additional data, most of these systems should exhibit detectable transit timing variations (TTVs) due to gravitational interactions, though none are apparent in these data. We also discuss new challenges that arise in TTV analyses due to the presence of more than two planets in a system.

270

AirShow 1.0 CFD Software Users' Guide  

Science.gov (United States)

AirShow is visualization post-processing software for Computational Fluid Dynamics (CFD). Upon reading binary PLOT3D grid and solution files into AirShow, the engineer can quickly see how hundreds of complex 3-D structured blocks are arranged and numbered. Additionally, chosen grid planes can be displayed and colored according to various aerodynamic flow quantities such as Mach number and pressure. The user may interactively rotate and translate the graphical objects using the mouse. The software source code was written in cross-platform Java, C++, and OpenGL, and runs on Unix, Linux, and Windows. The graphical user interface (GUI) was written using Java Swing. Java also provides multiple synchronized threads. The Java Native Interface (JNI) provides a bridge between the Java code and the C++ code where the PLOT3D files are read, the OpenGL graphics are rendered, and numerical calculations are performed. AirShow is easy to learn and simple to use. The source code is available for free from the NASA Technology Transfer and Partnership Office.

Mohler, Stanley R., Jr.

2005-01-01

271

"Skinless wonders": Body Worlds and the Victorian freak show.  

Science.gov (United States)

In 2002, Gunther von Hagens's display of plastinated corpses opened in London. Although the public was fascinated by Body Worlds, the media largely castigated the exhibition by dismissing it as a resuscitated Victorian freak show. By using the freak show analogy, the British press expressed their moral objection to this type of bodily display. But Body Worlds and nineteenth-century displays of human anomalies were linked in more complex and telling ways as both attempted to be simultaneously entertaining and educational. This essay argues that these forms of corporeal exhibitionism are both examples of the dynamic relationship between the popular and professional cultures of the body that we often erroneously think of as separate and discrete. By reading Body Worlds against the Victorian freak show, I seek to generate a fuller understanding of the historical and enduring relationship between exhibitionary culture and the discourses of science, and thus to argue that the scientific and the spectacular have been, and clearly continue to be, symbiotic modes of generating bodily knowledge. PMID:22661573

Durbach, Nadja

2014-01-01

272

Five Kepler target stars that show multiple transiting exoplanet candidates  

Energy Technology Data Exchange (ETDEWEB)

We present and discuss five candidate exoplanetary systems identified with the Kepler spacecraft. These five systems show transits from multiple exoplanet candidates. Should these objects prove to be planetary in nature, then these five systems open new opportunities for the field of exoplanets and provide new insights into the formation and dynamical evolution of planetary systems. We discuss the methods used to identify multiple transiting objects from the Kepler photometry as well as the false-positive rejection methods that have been applied to these data. One system shows transits from three distinct objects while the remaining four systems show transits from two objects. Three systems have planet candidates that are near mean motion commensurabilities - two near 2:1 and one just outside 5:2. We discuss the implications that multitransiting systems have on the distribution of orbital inclinations in planetary systems, and hence their dynamical histories; as well as their likely masses and chemical compositions. A Monte Carlo study indicates that, with additional data, most of these systems should exhibit detectable transit timing variations (TTV) due to gravitational interactions - though none are apparent in these data. We also discuss new challenges that arise in TTV analyses due to the presence of more than two planets in a system.

Steffen, Jason H.; /Fermilab; Batalha, Natalie M.; /San Jose State U.; Borucki, William J.; /NASA, Ames; Buchhave, Lars A.; /Harvard-Smithsonian Ctr. Astrophys. /Bohr Inst.; Caldwell, Douglas A.; /NASA, Ames /SETI Inst., Mtn. View; Cochran, William D.; /Texas U.; Endl, Michael; /Texas U.; Fabrycky, Daniel C.; /Harvard-Smithsonian Ctr. Astrophys.; Fressin, Francois; /Harvard-Smithsonian Ctr. Astrophys.; Ford, Eric B.; /Florida U.; Fortney, Jonathan J.; /UC, Santa Cruz, Phys. Dept. /NASA, Ames

2010-06-01

273

A duplex kidney with dromedary hump showing altered hilar anatomy  

Directory of Open Access Journals (Sweden)

Full Text Available A comprehensive knowledge of the wide range of variations of renal vasculature and renal pelvis is mandatory to the anatomists for a better understanding of the embryology. It remains as the key issue in determining the technical feasibility of various endourologic procedures and innumerable intervention techniques besides kidney retrievals for transplantation. In the present case the duplex kidney showed lobulations on the anterior surface just adjacent to the hilar region. The midlateral portion of the convex lateral border of the kidney showed a small focal bulge –dromedary hump. At the hilum reversed anterio-posterior disposition of renal vasculature with anteriorly placed renal artery which bifurcated into two upper and lower anterior segmental branches. The renal vein formed by large tributaries arising from the hilum running towards the inferior vena cava. The renal pelvis was most posteriorly placed which showed a double pelvis. The upper pelvis was seen arising behind the renal vein and the lower pelvis arising inferomedial to the lower anterior segmental artery.Both the pelvises were seen uniting medial to the lower part of hilum and continued as a single ureter which opened into the bladder. The thorough knowledge of these anatomical variations is necessary to avoid iatrogenic injuries and enable the surgeon and radiologists approach unusual situations with confidence rather than surprise.

Tallapaneni S

2011-02-01

274

How It's Done... U-Pb Geochronology Slide Shows  

Science.gov (United States)

De-mystify the process of isotope geochronology through this illustrated slide set that explains U-Pb geochronology from collecting samples in the field through processing them in the lab and interpreting the results.

University, Isotope G.

275

MEK: A Single Drug Target Shows Promise in Multiple Cancers  

Science.gov (United States)

Drugs that block the MEK protein have shown promise in several cancers. Trametinib has had encouraging results in patients with advanced melanoma, and selumetinib has been tested in patients with advanced thyroid and ovarian cancers.

276

Adolescents with Autism Spectrum Disorder Show a Circumspect Reasoning Bias Rather than "Jumping-to-Conclusions"  

Science.gov (United States)

People with autism spectrum disorders (ASD) often take longer to make decisions. The Autism-Psychosis Model proposes that people with autism and psychosis show the opposite pattern of results on cognitive tasks. As those with psychosis show a jump-to-conclusions reasoning bias, those with ASD should show a circumspect reasoning bias.…

Brosnan, Mark; Chapman, Emma; Ashwin, Chris

2014-01-01

277

Evaluation of the ductile-to-brittle transition temperature shift due to temper embrittlement and neutron irradiation by means of a small-punch test  

International Nuclear Information System (INIS)

By means of a small-punch testing technique, the effects of heterogeneous intergranular impurity segregation and neutron irradiation on the ductile-to-brittle transition temperature (DBTT) of impurity-doped and undoped alloy steels were investigated. It was found that antimony-doped steels and, in particular, non-homogenized steels with extremely heterogeneous intergranular dopant segregation frequently show initiation of microcracks as indicated by the appearance of serrations in the load-deflection curves. In this case the ductile to brittle transition is spread out over a wider temperature range than for tin- or phosphorus-doped steels as well as for undoped steel. The upper and lower bounds of the DBTT are uniquely correlated with the maximum and average values of the impurity segregation concentration distributed along grain boundaries. These relationships demonstrate the embrittling potency of the segregants, in agreement with results obtained from Charpy V-notch tests. Neutron irradiation of tin-doped steels caused the DBTT to shift to higher temperatures than that of undoped steels. The experimental results suggest a linear correlation between the DBTTs obtained from small-punch tests and those obtained from Charpy V-notch tests, as predicted by a recently developed kinetic model. (orig.)

278

Directional chemical variations in diamonds showing octahedral following cuboid growth  

Science.gov (United States)

A progression from cuboid to octahedral growth has been observed in 16 natural diamonds from Yakutian kimberlites. X-ray and cathodoluminescence topography have revealed that the change in morphology of diamonds with cloudy cuboid cores may occur without mixed-habit growth but via generation of numerous octahedral apices on cuboid surfaces and subsequent gradual transformation into regular octahedral morphology. Nitrogen aggregation in both cuboid and octahedral domains of such diamonds suggests that they have had a long residence time under mantle conditions. Micro-inclusions in the cuboid domains of the diamonds testify to the nucleation and growth of cuboid cores from a hydrous-carbonatitic (oxidized) fluid. The transition from cuboid hummocky growth rich in inclusions to octahedral growth without inclusions may be linked to decreasing supersaturation in the parent fluid. Measurements of ?13C and Nppm by ion microprobe show that the chemical variations observed between inner cuboid domains and outer octahedral zones commonly have a systematic character and as such they are probably not due to purely kinetic effects. The peripheral octahedral zones are always enriched in 13C in comparison with inner cuboid ones, and the total nitrogen content decreases with the change from cuboid to octahedral growth. The octahedral outer zones show a gradual progressive increase in ?13C, with an overall change of up to 5‰ from the cuboid core (?13C usually between -8 and -6‰) to the diamond margin (?13C usually between -4 and -2‰). Decreases in ?13C of this magnitude with a gradual increase in 13C may be attributed to the Rayleigh fractionation operating on a single parent fluid of close to normal mantle ?13C composition with diamond precipitating by the reduction of carbonatitic fluid in a closed system. However, one sample shows a variation of ?13C of approximately -17 to -6‰ and therefore suggests a possible change of fluid source composition from one containing subducted crustal organic carbon to one with common mantle carbon.

Zedgenizov, D. A.; Harte, B.; Shatsky, V. S.; Politov, A. A.; Rylov, G. M.; Sobolev, N. V.

2006-01-01

279

A Technique for Showing Causal Arguments in Accident Reports  

Science.gov (United States)

In the prototypical accident report, specific findings, particularly those related to causes and contributing factors, are usually written out explicitly and clearly. Also, the evidence upon which these findings are based is typically explained in detail. Often lacking, however, is any explicit discussion, description, or depiction of the arguments that connect the findings and the evidence. That is, the reports do not make clear why the investigators believe that the specific evidence they found necessarily leads to the particular findings they enumerated. This paper shows how graphical techniques can be used to depict relevant arguments supporting alternate positions on the causes of a complex road-traffic accident.

Holloway, C. M.; Johnson, C. W.

2005-01-01

280

Paks surveillance shows reactor vessels safe from embrittlement  

International Nuclear Information System (INIS)

Surveillance of Hungary's Paks VVER 440 Pressurized Water Reactors by means of ''Loviisa-type'' shows that embrittlement of the reactor pressure vessels should not be a problem during their operational lifetime. Each reactor pressure vessel has six sets of specimens consisting of base metal (Cr-Mo-V alloyed steel), heat affected zone and weld. A set consists of twelve Charpy V specimens, twelve Charpy size 10 three-point-band specimens and six tensile specimens. Two sets are for studying thermal embrittlement. The specimens are located between the core and the vessel walls. (author)

 
 
 
 
281

Electricity show and related educational programming. Final report  

Energy Technology Data Exchange (ETDEWEB)

The on-site version of Balance of Power reached a total audience of 21,331 between November 10, 1994 and January 31, 1996; in addition, the Physics on Wheels van offered exhibits and programs to an additional 30,000 students in the 1995-1996 school year. The program provided a groundbreaking new approach to informal science education, combining a dynamic demonstration with an intensely interactive game show. Between the on-site programming and the Physics on Wheels van programs, 51,331 students were impacted by the activities, exhibits and energy-conservation message of Balance of Power.

NONE

1997-03-19

282

New cancer drug shows promise for treating advanced melanoma  

Science.gov (United States)

Researchers from UCLA's Jonsson Comprehensive Cancer Center report that a new drug in preliminary tests has shown promising results with very manageable side effects for treating patients with melanoma, the deadliest form of skin cancer. The results were presented at the 2013 meeting of the American Society of Clinical Oncology today in Chicago by Dr. Antoni Ribas, professor of medicine in the UCLA division of hematology-oncology, who led the research. Following Ribas’ presentation, the study was published online ahead of press in the New England Journal of Medicine.

283

Mixtures of thermostable enzymes show high performance in biomass saccharification.  

Science.gov (United States)

Optimal enzyme mixtures of six Trichoderma reesei enzymes and five thermostable enzyme components were developed for the hydrolysis of hydrothermally pretreated wheat straw, alkaline oxidised sugar cane bagasse and steam-exploded bagasse by statistically designed experiments. Preliminary studies to narrow down the optimization parameters showed that a cellobiohydrolase/endoglucanase (CBH/EG) ratio of 4:1 or higher of thermostable enzymes gave the maximal CBH-EG synergy in the hydrolysis of hydrothermally pretreated wheat straw. The composition of optimal enzyme mixtures depended clearly on the substrate and on the enzyme system studied. The optimal enzyme mixture of thermostable enzymes was dominated by Cel7A and required a relatively high amount of xylanase, whereas with T. reesei enzymes, the high proportion of Cel7B appeared to provide the required xylanase activity. The main effect of the pretreatment method was that the required proportion of xylanase was higher and the proportion of Cel7A lower in the optimized mixture for hydrolysis of alkaline oxidised bagasse than steam-exploded bagasse. In prolonged hydrolyses, less Cel7A was generally required in the optimal mixture. Five-component mixtures of thermostable enzymes showed comparable hydrolysis yields to those of commercial enzyme mixtures. PMID:24752938

Kallioinen, Anne; Puranen, Terhi; Siika-aho, Matti

2014-07-01

284

[A case of miliary tuberculosis showing diffuse alveolar hemorrhage].  

Science.gov (United States)

A 43-year-old diabetic man had a productive cough and high fever and was admitted to another hospital. His condition did not improve despite treatment with Cefepime, and he was transferred to our hospital. Chest X-ray films and CT findings showed pulmonary infiltration and diffuse ground-glass opacities in bilateral lung fields, but disseminated nodules were not identified. Since his bronchial lavage fluid (BALF) was bloody, we suspected diffuse alveolar hemorrhage due to vasculitis. Steroid pulse therapy was given, and his fever and chest X-ray findings completely improved. However, 1 week later, he again suffered a high fever and bloody sputum, and a chest X-ray film showed granular shadows in bilateral lung fields. He died of respiratory failure on the 18th hospital day despite treatment and mechanical ventilation. An autopsy revealed many necrotizing epithelioid granulomas in both lungs, the liver, the spleen, both kidneys and both adrenal glands. These findings indicated miliary tuberculosis, and a culture of his sputum and BALF finally revealed mycobacterium tuberculosis. Marked alveolar hemorrhage and a hyaline membrane were also found in both lungs, but vasculitis was not recognized in any organ. We report this case, because to the best of our knowledge diffuse alveolar hemorrhage has not been reported as the primary symptom of miliary tuberculosis. PMID:21842695

Nakamura, Sukeyuki; Kamioka, Eiko; Tokuda, Atsuko; Tabeta, Hiroshi

2011-07-01

285

Herbarium specimens show contrasting phenological responses to Himalayan climate.  

Science.gov (United States)

Responses by flowering plants to climate change are complex and only beginning to be understood. Through analyses of 10,295 herbarium specimens of Himalayan Rhododendron collected by plant hunters and botanists since 1884, we were able to separate these responses into significant components. We found a lack of directional change in mean flowering time over the past 45 y of rapid warming. However, over the full 125 y of collections, mean flowering time shows a significant response to year-to-year changes in temperature, and this response varies with season of warming. Mean flowering advances with annual warming (2.27 d earlier per 1 °C warming), and also is delayed with fall warming (2.54 d later per 1 °C warming). Annual warming may advance flowering through positive effects on overwintering bud formation, whereas fall warming may delay flowering through an impact on chilling requirements. The lack of a directional response suggests that contrasting phenological responses to temperature changes may obscure temperature sensitivity in plants. By drawing on large collections from multiple herbaria, made over more than a century, we show how these data may inform studies even of remote localities, and we highlight the increasing value of these and other natural history collections in understanding long-term change. PMID:25002486

Hart, Robbie; Salick, Jan; Ranjitkar, Sailesh; Xu, Jianchu

2014-07-22

286

Chromosomal imbalances in carcinoma showing thymus-like elements (CASTLE).  

Science.gov (United States)

Carcinoma showing thymus-like elements (CASTLE) is a rare neoplasm of the thyroid gland resembling lymphoepithelioma-like and squamous cell carcinoma of the thymus and is thought to arise from ectopic thymic tissue within the thyroid gland or rudimentary branchial pouches along the thymic line. Using comparative genomic hybridization (CGH), chromosomal imbalances have been detected in several types of thymomas and thymic carcinomas. To evaluate whether there are hints of an underlying sequence in the pathogenesis of CASTLE analogue to those found in thymomas and thymic carcinomas, we evaluated four of these rare neoplasms for chromosomal imbalances using CGH. The most frequent gains were seen on chromosomal arm 1q (3/4), and losses were most frequently detected on 6p (4/4), 6q (3/4) and 16q (3/4). These CGH data show that CASTLE is characterized by chromosomal imbalances similar to those found in thymomas and thymic carcinomas and indicate a similar sequence in tumour development. PMID:21735166

Veits, Lothar; Mechtersheimer, Gunhild; Steger, Christina; Freitag, Jens; Mikuz, Gregor; Schmid, Kurt W; Hofmann, Walter; Schirmacher, Peter; Hartmann, Arndt; Rieker, Ralf J

2011-08-01

287

Drilling and production - Economics show CO2 EOR potential  

Science.gov (United States)

CO2 EOR may be the key to recovering hundreds of millions of bbl of trapped oil from the mature fields in central Kansas. A simple model aided in assessing the economics of CO2 EOR for central Kansas and the Midcontinent. The model used CO2 Prophet, a DOE freeware reservoir numerical simulation program, to determine reservoir performance, including injected and produced fluid rates, and CO2 utilization. Economic parameters, e.g., oil price, CO2 costs, capital costs, net revenue interest, production taxes, and lease operating expenses, are typical for anticipated conditions in the region and present price climate. Preliminary economic analysis shows that CO2 EOR should give an internal rate of return (IRR) > 20%, before income tax, assuming oil sells for $20/bbl, CO2 costs $1/million cu ft, and gross utilization is 10 million cu ft of CO2/bbl of oil recovered. If the CO2 is reduced to $0.75/million cu ft, an oil price of $17/bbl yields an IRR of 20%. Reservoir and economic modeling shows that IRR is most sensitive to oil price and CO2 cost.

Dubois, M. K.; Byrnes, A. P.

2000-01-01

288

La Realidad Simulada. Una Crítica del reality show / The simmulation of Reality. A critic of the reality show.  

Scientific Electronic Library Online (English)

Full Text Available SciELO Colombia | Language: Spanish Abstract in spanish El reality show es el formato televisivo más exitoso de los últimos años. Este artículo efectúa una exploración en torno a dicho formato articulada en tres partes. Primero, se estudiará la tensión que los realities generan entre la representación como esquema estético tradicional y la simulación com [...] o esquema estético emergente; luego, se detallará la manera en que los realities participan en la producción del mundo como imagen; finalmente, se explicará el papel que los realities cumplen en el marco de la economía estética contemporánea y se ofrecerá una explicación sociopsicológica de su poder de seducción. El artículo en su conjunto aborda el estudio del reality a través del lente amplio de una crítica de la industria del entretenimiento. Abstract in english Reality shows are one of the most successful television genres in the last few years. The exploration that this article will make around this genre consists of three parts. First, the tension that realities cause between representation as a traditional aesthetic style and simulation as an emergent a [...] esthetic style will be examined. Second, the way realities participate in the construction of the world as image will be described. Finally, the article will explain the role that realities play in the contemporary aesthetic economy, and offer a socio-psychological explanation of its seductive power. The article approaches the study of reality shows by taking a critical perspective to the entertainment industry.

Leonardo, Ordóñez Díaz.

2005-05-30

289

La Realidad Simulada. Una Crítica del reality show The simmulation of Reality. A critic of the reality show.  

Directory of Open Access Journals (Sweden)

Full Text Available El reality show es el formato televisivo más exitoso de los últimos años. Este artículo efectúa una exploración en torno a dicho formato articulada en tres partes. Primero, se estudiará la tensión que los realities generan entre la representación como esquema estético tradicional y la simulación como esquema estético emergente; luego, se detallará la manera en que los realities participan en la producción del mundo como imagen; finalmente, se explicará el papel que los realities cumplen en el marco de la economía estética contemporánea y se ofrecerá una explicación sociopsicológica de su poder de seducción. El artículo en su conjunto aborda el estudio del reality a través del lente amplio de una crítica de la industria del entretenimiento.Reality shows are one of the most successful television genres in the last few years. The exploration that this article will make around this genre consists of three parts. First, the tension that realities cause between representation as a traditional aesthetic style and simulation as an emergent aesthetic style will be examined. Second, the way realities participate in the construction of the world as image will be described. Finally, the article will explain the role that realities play in the contemporary aesthetic economy, and offer a socio-psychological explanation of its seductive power. The article approaches the study of reality shows by taking a critical perspective to the entertainment industry.

Leonardo Ordóñez Díaz

290

Persistent pemphigus vulgaris showing features of tufted hair folliculitis.  

Science.gov (United States)

Pemphigus vulgaris is an autoimmune blistering disease that commonly involves the scalp. Lesions of pemphigus vulgaris that persist on the scalp for a long period may be accompanied by tufted hair folliculitis. Only two previous accounts of tufted hair folliculitis developing in a lesion of pemphigus vulgaris have been reported. We report a 51-year-old-man with erosions and clusters of hair on the scalp. The scalp lesion had persisted for about 20 years. A histopathological examination of the skin lesion on the scalp revealed separation of the epidermis and clusters of several adjacent hair follicles. The patient was diagnosed with persistent pemphigus vulgaris of the scalp showing features of tufted hair folliculitis. PMID:22148026

Ko, Dong Kyun; Chae, In Soo; Chung, Ki Hun; Park, Joon Soo; Chung, Hyun

2011-11-01

291

Thalamocortical inputs show post-critical-period plasticity.  

Science.gov (United States)

Experience-dependent plasticity in the adult brain has clinical potential for functional rehabilitation following central and peripheral nerve injuries. Here, plasticity induced by unilateral infraorbital (IO) nerve resection in 4-week-old rats was mapped using MRI and synaptic mechanisms were elucidated by slice electrophysiology. Functional MRI demonstrates a cortical potentiation compared to thalamus 2 weeks after IO nerve resection. Tracing thalamocortical (TC) projections with manganese-enhanced MRI revealed circuit changes in the spared layer 4 (L4) barrel cortex. Brain slice electrophysiology revealed TC input strengthening onto L4 stellate cells due to an increase in postsynaptic strength and the number of functional synapses. This work shows that the TC input is a site for robust plasticity after the end of the previously defined critical period for this input. Thus, TC inputs may represent a major site for adult plasticity in contrast to the consensus that adult plasticity mainly occurs at cortico-cortical connections. PMID:22632730

Yu, Xin; Chung, Seungsoo; Chen, Der-Yow; Wang, Shumin; Dodd, Stephen J; Walters, Judith R; Isaac, John T R; Koretsky, Alan P

2012-05-24

292

Normal rats trained to circle show asymmetric caudate dopamine release.  

Science.gov (United States)

Caudate catecholamine release was monitored by bilateral in vivo electrochemical electrodes in male Sprague-Dawley rats trained to circle for sucrose/water reward. Baseline release of dopamine was equal from both sides of caudate. When reinforced circling began, 44 +/- 4 percent greater catechol release occurred from the caudate contralateral to the circling direction. As turning subsided, differential release returned to basal levels. Further evidence that the catecholamine metabolism was affected by turning was obtained by direct measurement of caudate dopamine and DOPAC at selected time points. Concentration data showed relative increases in dopamine and DOPAC in the contralateral caudate. These data provide evidence that dopamine is released asymmetrically from caudate in unlesioned rats during voluntary behavior. PMID:7109843

Yamamoto, B K; Lane, R F; Freed, C R

1982-06-21

293

Low LET protons focused to submicrometer shows enhanced radiobiological effectiveness  

International Nuclear Information System (INIS)

This study shows that enhanced radiobiological effectiveness (RBE) values can be generated focusing low linear energy transfer (LET) radiation and thus changing the microdose distribution. 20 MeV protons (LET = 2.65 keV µm?1) are focused to submicrometer diameter at the ion microprobe superconducting nanoprobe for applied nuclear (Kern) physics experiments of the Munich tandem accelerator. The RBE values, as determined by measuring micronuclei (RBEMN = 1.48 ± 0.07) and dicentrics (RBED = 1.92 ± 0.15), in human–hamster hybrid (AL) cells are significantly higher when 117 protons were focused to a submicrometer irradiation field within a 5.4 × 5.4 µm2 matrix compared to quasi homogeneous in a 1 × 1 µm2 matrix applied protons (RBEMN = 1.28 ± 0.07; RBED = 1.41 ± 0.14) at the same average dose of 1.7 Gy. The RBE values are normalized to standard 70 kV (dicentrics) or 200 kV (micronuclei) x-ray irradiation. The 117 protons applied per point deposit the same amount of energy like a 12C ion with 55 MeV total energy (4.48 MeV u?1). The enhancements are about half of that obtained for 12C ions (RBEMN = 2.20 ± 0.06 and RBED = 3.21 ± 0.10) and they are attributed to intertrack interactions of the induced damages. The measured RBE values show differences from predictions of the local effect model (LEM III) that is used to calculate RBE values for irradiation plans to treat tumors with high LET particles. (paper)

294

Simple Blunt Trauma and Diaphragmatic Rupture Showing Delayed Clinical Signs  

Directory of Open Access Journals (Sweden)

Full Text Available The diaphragm provides the progression between certain structures and the chest cavity by means of an anatomic hiatus. The diaphragm is the second most functional muscle structure of the body after the heart. Diaphragm injuries may result from serious blunt or penetrating injuries. While most of the blunt diaphragm infuries are caused by traffic accidents and falls from heights, some may occur as a result of other blunt traumas to the lower chest or epigastrium. Diaphragm injuries may be seen in t 0.8-1.6% of the patients hospitalized due to blunt abdominal trauma. In this study, we will report that a diaphagm injury of a patient who has a history of blunt abdominal trauma was diagnosed six months after the trauma when he was admitted to hospital because of stomach ache and pain in his left chest.

Tar?k Ocak

2012-01-01

295

Solar home show: Homes designed for the solar homebuilders program  

Science.gov (United States)

Ten passive solar homes are presented that resulted from a program to demonstrate that passive solar homes can be attractive, affordable, functional, and therefore, marketable. For each home is given: the designer and builder, floor plans, perspective of the outside, passive solar and conservation features, and a comparison of the estimated heating bill for the house and a conventional house the same size. A brief discussion is included on the basics of passive solar design, ventilation and cooling, and solar access.

1982-07-01

296

First prospective trial shows molecular profiling timely for tailoring therapy  

Science.gov (United States)

A clinical trial has shown that patients were willing to undergo an additional cancer biopsy, to seek out the best treatment for their tumor type through analysis to find and target genetic mutations that drive the cancer. Results of the study, CUSTOM, begun at the National Cancer Institute and completed at the Georgetown Lombardi Comprehensive Cancer Center, are being presented at the 2013 annual meeting of the American Society of Clinical Oncology. Researchers at Oregon Health & Science University also participated.

297

Cell-based immune therapy shows promise in leukemia patients  

Science.gov (United States)

Memorial Sloan-Kettering investigators report that genetically modified immune cells have shown great promise in killing the cancer cells of patients with relapsed B cell acute lymphoblastic leukemia (ALL). In fact, all five of the patients who have received the new therapy – known as targeted immunotherapy – have gone into complete remission, with no detectable cancer cells. The results of this ongoing clinical trial are reported online on March 20 in the journal Science Translational Medicine.

298

Three small systems showing probable room-temperature superconductivity  

Energy Technology Data Exchange (ETDEWEB)

I shall discuss three small systems in which I think room-temperature superconductivity has been observed, in the hope that experimentalists will be persuaded to try to reproduce and extend results on some or all of the three systems mentioned. These are: (1) narrow channels through films of oxidised atactic polypropylene (OAPP) and other polymers. (2) Some multiwalled carbon nanotubes or mats of nanotubes. (3) Sandwich structures based on CdF{sub 2}. The main emphasis will be on polymer films.

Eagles, D.M., E-mail: d.eagles@ic.ac.uk [19 Holt Road, Harold Hill, Romford, Essex RM3 8PN (United Kingdom)

2012-12-14

299

Static and impact crack properties of a high-strength steel welded joint  

International Nuclear Information System (INIS)

In order to gain the benefits of weldable high-strength steels in pressurized equipment applications, satisfactory toughness and crack properties of the welded joint, both in the weld metal and the heat-affected -zone (HAZ), are required. Experimental investigations of toughness and crack resistance parameters through static and impact tests of a high-strength, low-alloy steel (HSLA) with a nominal yield strength of 700 MPa and its welded joint, were performed on Charpy-sized specimens, V-notched and pre-cracked, of the parent metal, weld metal and HAZ. The selected electrode produced slight undermatching and enabled the welded joints to be manufactured without cold cracks. The impact energy and its parts responsible for crack initiation and propagation were determined by toughness evaluation. Crack sensitivity, defined as the ratio of the impact energy for V-notched and for pre-cracked specimens, enabled a comparison of the homogeneous microstructure of the parent metal and the weld metal, and of the heterogeneous microstructure of the heat-affected-zone (HAZ), which indicated a better crack toughness behaviour of the HAZ. The results obtained showed that the toughness and crack resistance of the weld metal were significantly lower than those of the parent metal and the HAZ. The fracture mechanics parameters, J Ic integral, and plane strain fracture toughness, K Ic, as well as J resistance curves expressed the degradation lessed the degradation less

300

Nano-textured W shows improvement of thermionic emission properties  

Energy Technology Data Exchange (ETDEWEB)

Laser-assisted nano-texturing of W substrates cathodes via ablation in liquid environment is experimentally realized. Two laser sources are used, either a Ti:sapphire femtosecond laser or a Nd:YAG laser with pulse duration of 350 ps. Laser exposure of W results in the formation of hemi-spherical nanostructures situated on top of periodic ripples. Nano-textured thermionic W cathode demonstrates the decrease of the efficient work function by 0.3 eV compared to pristine surface. (orig.)

Barmina, E.V.; Serkov, A.A.; Shafeev, G.A. [General Physics Institute of the Russian Academy of Sciences, Wave Research Center of A.M. Prokhorov, Moscow (Russian Federation); Stratakis, E. [Institute of Electronic Structure and Laser, Foundation for Research and Technology - Hellas, (IESL-FORTH), Heraklion (Greece); University of Crete, Materials Science and Technology Department, Heraklion (Greece); Fotakis, C. [Institute of Electronic Structure and Laser, Foundation for Research and Technology - Hellas, (IESL-FORTH), Heraklion (Greece); University of Crete, Physics Department, Heraklion (Greece); Stolyarov, V.N.; Stolyarov, I.N. [Roentgenprom, Protvino, Moscow (Russian Federation)

2012-01-15

 
 
 
 
301

Nano-textured W shows improvement of thermionic emission properties  

International Nuclear Information System (INIS)

Laser-assisted nano-texturing of W substrates cathodes via ablation in liquid environment is experimentally realized. Two laser sources are used, either a Ti:sapphire femtosecond laser or a Nd:YAG laser with pulse duration of 350 ps. Laser exposure of W results in the formation of hemi-spherical nanostructures situated on top of periodic ripples. Nano-textured thermionic W cathode demonstrates the decrease of the efficient work function by 0.3 eV compared to pristine surface. (orig.)

302

TRPV1 shows dynamic ionic selectivity during agonist stimulation.  

Science.gov (United States)

Transient receptor potential vanilloid 1 (TRPV1) is an ion channel that is gated by noxious heat, capsaicin and other diverse stimuli. It is a nonselective cation channel that prefers Ca2+ over Na+. These permeability characteristics, as in most channels, are widely presumed to be static. On the contrary, we found that activation of native or recombinant rat TRPV1 leads to time- and agonist concentration-dependent increases in relative permeability to large cations and changes in Ca2+ permeability. Using the substituted cysteine accessibility method, we saw that these changes were attributable to alterations in the TRPV1 selectivity filter. TRPV1 agonists showed different capabilities for evoking ionic selectivity changes. Furthermore, protein kinase C-dependent phosphorylation of Ser800 in the TRPV1 C terminus potentiated agonist-evoked ionic selectivity changes. Thus, the qualitative signaling properties of TRPV1 are dynamically modulated during channel activation, a process that probably shapes TRPV1 participation in pain, cytotoxicity and neurotransmitter release. PMID:18391945

Chung, Man-Kyo; Güler, Ali D; Caterina, Michael J

2008-05-01

303

Show: Dr. H, the life and death of pancakes  

CERN Multimedia

Dr. H, the life and death of pancakes, a comic theatrical creation, written and performed by Heiko Buchholz.   Monday 2 April 2012 in German Tuesday 3 April 2012 in English Wednesday 4 April 2012 in French 8:30 p.m. at the Globe of Science and Innovation. This production takes a comic look at scientific methods, as applied to a common object: the pancake. More specifically, Dr H. regales his audience with statistics, experiments and scientific data surrounding this egg-and-milk-based culinary delight. And although these zany sketches are nothing short of absurd, the audience is drawn in more often than you might expect… and taken on quite an unexpected journey into the behavioural disorders, personality quirks and psychoanalysis of the base pancake. This show playfully mocks scientific logic and discourse, forcing the audience to reflect on their gullibility in the face of science and its impenetrable jargon. It purports to be neither explanation nor illustration of scientific fact,...

2012-01-01

304

WSSV-induced crayfish Dscam shows durable immune behavior.  

Science.gov (United States)

One of the major gaps in our understanding of arthropod specific immune priming concerns the mechanism[s] by which the observed long-term (>2 weeks) protective effects might be mediated. Hypervariable Dscam (Down syndrome cell adhesion molecule) might support arthropod innate immunity with specificity for more extended periods. We show here that, in the relatively long-lived arthropod Cherax quadricarinatus, CqDscam does not behave like a typical, immediately-acting, short-lived innate immune factor: CqDscam was not induced within hours after challenge with a lethal virus, but instead was only up-regulated after 2-5 days. This initial response faded within ? 2 weeks, but another maximum was reached ? 1 month later. At around 2 months after the initial challenge, the virus-induced CqDscam bound to the virus virion and acted to neutralize the virus However, although CqDscam helped crayfish to survive during persistent infection, it nevertheless failed to provide any enhanced protection against a subsequent WSSV challenge. Thus, CqDscam is capable of supporting extended anti-virus immune memory in arthropods. Also, during a persistent virus infection, the balance of "immune firepower" in crayfish appears to be altered such that the general immune factors become depleted while CqDscam becomes relatively predominant. PMID:24973514

Ng, Tze Hann; Hung, Hsin-Yi; Chiang, Yi-An; Lin, Jia-Hung; Chen, Yi-Ning; Chuang, Ya-Chu; Wang, Han-Ching

2014-09-01

305

Showing Food Foams Properties with Common Dairy Foods  

Science.gov (United States)

Most writers on food either ignore scientific principles that underlie cooking or disparage the value of such information on the grounds that can not be easily reduced to the test tube. However, people who have not yet logged years preparing food might require some explanation about what is going on or just simple may be curious about what foods are and how cooking works. In this work we show some easy to carry, inexpensive and safe experiments developed using familiar kitchen materials related with egg foams. Eggs's properties are not only limited to prepare excellent and delicious emulsions like mayonnaise but also makes excellent foams, increasing their volume significantly in two primary ways: the first one may be attributed to the albumen (a major component of egg white) because it is a thick viscous solution and it drains more slowly out of bubble walls than does a thin liquid and the second one is because egg white introduces a kind of reinforcement into the bubble walls. As the egg white is beaten and air bubbles are incorporated into it, the proteins in the bubble wall are subjected to an imbalance of forces due to the air-liquid interface which makes them to unfold and bond each other forming a delicate but definitely reinforcing network.

Bravo-Diaz, Carlos; Gonzalez-Romero, Elisa

1997-09-01

306

Film showing - Higgs: into the heart of imagination  

CERN Multimedia

On 29 April at 7pm Dutch filmmakers, Hannie van den Bergh and Jan van den Berg, will introduce their directorial debut, Higgs: into the heart of imagination in CERN’s Main Auditorium.   This documentary is about the curiousity, passion and imaginative powers of science. Featuring physicists working at CERN, in particular in ATLAS, and filmed over four years, the film-makers have created a cinematic journey into the heart of imagination. They follow Stan Bentvelsen, head of the Dutch research group at CERN, and watch as he prepares his team for the start of the LHC, as well as the scientific competition to find the elusive Higgs particle. The film also features Peter Higgs as he discusses his work from 1964. The directors have created theatre productions and other multimedia projects under the title The Imagination of Invisible Dimensions, which allow for adventurous dialogues between art and science. All are welcome to attend this showing and afterwards there will be a short question...

CERN Bulletin

2010-01-01

307

Chinese dyslexics show neural differences in morphological processing.  

Science.gov (United States)

Previous behavioral studies have suggested that morphological awareness is impaired in Chinese children with reading disability (RD), but how this is reflected in brain alterations is not known. Using functional magnetic resonance imaging (fMRI), the current study compared morphological processing in a RD group (11-13 years old) to an age-matched typically developing (TD) group. Participants made semantic relatedness judgments to incongruent word pairs that were either semantically related but did not share a morpheme or semantically unrelated but did share a morpheme. This was compared to conditions where semantic relatedness and morphemic information was congruent. A smaller incongruency effect was found in left dorsal posterior (BA9) and ventral anterior (BA47) inferior frontal gyrus (IFG) in the RD compared to the TD, suggesting that the RD is less sensitive to morphological information. This was a specific deficit as a phonological control task that manipulated congruency between orthography and phonology did not show group differences in the IFG. Moreover, brain activation in the IFG for the incongruency effect in the semantic task was negatively correlated with reading skill for the RD group only, suggesting that higher skill children with RD may rely on a compensatory whole-word strategy by ignoring the morphemic information. PMID:23872198

Liu, Li; Tao, Ran; Wang, Wenjing; You, Wenping; Peng, Danling; Booth, James R

2013-10-01

308

Sulfur dioxide - Episodic injection shows evidence for active Venus volcanism  

Science.gov (United States)

Pioneer Venus ultraviolet spectra from the first 5 years of operation show a decline (by more than a factor of 10) in sulfur dioxide abundance at the cloud tops and in the amount of submicron haze above the clouds. At the time of the Pioneer Venus encounter, the values for both parameters greatly exceeded earlier upper limits. However, Venus had a similar appearance in the late 1950's, implying the episodic injection of sulfur dioxide possibly caused by episodic volcanism. The amount of haze in the Venus middle atmosphere is about ten times that found in earth's stratosphere after the most recent major volcanic eruptions, and the thermal energy required for this injection on Venus is greater by about an order of magnitude than the largest of these recent earth eruptions and about as large as the Krakatoa eruption of 1883. The episodic behavior of sulfur dioxide implies that steady-state models of the chemistry and dynamics of cloud-top regions may be of limited use.

Esposito, L. W.

1984-01-01

309

Dust Storm Time Lapse Shows Opportunity's Skies Darken  

Science.gov (United States)

[figure removed for brevity, see original site] Dust Storm Time Lapse Shows Opportunity's Skies Darken NASA's Opportunity rover is literally seeing some of its darkest days. Both Mars Exploration Rovers have been riding out a regional dust storm for several weeks. Conditions became particularly dreary in the Meridiani Planum region where Opportunity sits, perched on the edge of 'Victoria Crater.' This image is a time-lapse composite where each horizon-survey image has been compressed horizontally (but not vertically) to emphasize the sky. The relative brightness and darkness of the sky from sol to sol (over a 30-sol period beginning June 14, 2007) is depicted accurately in these images, which view roughly the same part of the plains southwest of the rover. The images are approximately true color composites, generated from calibrated radiance data files using the panoramic camera's 601-nanometer, 535-nanometer and 482-nanometer filters. The rovers' atmospheric science team is concerned that smaller, regional dust storms could expand into a larger, globe-encircling storm. That could extend the time the sun stays obscured, challenging the capability of Opportunity's solar panels to produce enough electricity for the rover to function. Fortunately, as of July 19, 2007, the Opportunity site is clearing slightly. When the storm ends, atmospheric scientists hope to review data from the rovers that will help them determine what sort of dust was being lifted and distributed. The numbers across the top of the image report a measurement of atmospheric opacity, called by the Greek letter tau. The lower the number, the clearer the sky. Both Opportunity and Spirit have been recording higher tau measurements in July 2007 than they had seen any time previously in their three and a half years on Mars. The five sol numbers across the bottom correspond (left to right) to June 14, June 30, July 5, July 13 and July 15, 2007.

2007-01-01

310

Children with autism show reduced somatosensory response: an MEG study.  

Science.gov (United States)

The neural underpinnings of sensory processing differences in autism remain poorly understood. This prospective magnetoencephalography (MEG) study investigates whether children with autism show atypical cortical activity in the primary somatosensory cortex (S1) in comparison with matched controls. Tactile stimuli were clearly detectable, and painless taps were applied to the distal phalanx of the second (D2) and third (D3) fingers of the right and left hands. Three tactile paradigms were administered: an oddball paradigm (standard taps to D3 at an interstimulus interval (ISI) of 0.33 and deviant taps to D2 with ISI ranging from 1.32?s to 1.64?s); a slow-rate paradigm (D2) with an ISI matching the deviant taps in the oddball paradigm; and a fast-rate paradigm (D2) with an ISI matching the standard taps in the oddball. Study subjects were boys (age 7-11 years) with and without autism disorder. Sensory behavior was quantified using the Sensory Profile questionnaire. Boys with autism exhibited smaller amplitude left hemisphere S1 response to slow and deviant stimuli during the right-hand paradigms. In post-hoc analysis, tactile behavior directly correlated with the amplitude of cortical response. Consequently, the children were re-categorized by degree of parent-report tactile sensitivity. This regrouping created a more robust distinction between the groups with amplitude diminution in the left and right hemispheres and latency prolongation in the right hemisphere in the deviant and slow-rate paradigms for the affected children. This study suggests that children with autism have early differences in somatosensory processing, which likely influence later stages of cortical activity from integration to motor response. PMID:22933354

Marco, Elysa J; Khatibi, Kasra; Hill, Susanna S; Siegel, Bryna; Arroyo, Monica S; Dowling, Anne F; Neuhaus, John M; Sherr, Elliott H; Hinkley, Leighton N B; Nagarajan, Srikantan S

2012-10-01

311

Study to treat deadly form of thyroid cancer shows promise  

Science.gov (United States)

A combination of therapies may prove to be a promising advance for the treatment of anaplastic thyroid cancer based on results of a phase I clinical trial. The collaborative study, published in the April 16 online issue of the Journal of Clinical Endocrinology & Metabolism, reports that combining paclitaxel chemotherapy with an experimental agent known as efatutazone was safe and well tolerated by patients. Organizations participating in the study were: the Mayo Clinic, the University of Pennsylvania Abramson Cancer Center, Eastern Virginia University, the Dana-Farber Cancer Institute, Ohio State University (home to the OSU Comprehensive Cancer Center), the University of Oregon Medical Center (home to the Knight Cancer Institute), the University of Colorado School of Medicine (home to the University of Colorado Cancer Center), Emory University Hospital (home of the Winship Cancer Institute), Weill Cornell Medical College, and Japanese pharmaceutical company, Daiichi Sankyo.

312

High-resolution peatland photos show change with global warming  

Science.gov (United States)

As global average temperatures rise, vast tracks of peatland currently encased in permafrost will be affected. As the ground thaws, peatlands will evolve in either of two directions. Along one path, land that was previously propped up by supportive permafrost subsides, forming a shallow basin that fills with water—a thermokarst lake. In the new lake, peat undergoes anaerobic bacterial decay, releasing methane to the environment. Alternatively, permafrost thawing can result in lake drainage. In the drained lake beds, fen vegetation and mosses can grow, drawing down atmospheric carbon dioxide levels. The prevalence of these two processes, and their relationship to changing temperatures, remains an important question in understanding the consequences of permafrost thaw on the global carbon cycle.

Schultz, Colin

2011-11-01

313

Australian plants show anthelmintic activity toward equine cyathostomins in vitro.  

Science.gov (United States)

Anthelmintic resistance in gastrointestinal parasites of horses is an increasing problem, particularly in cyathostomins, and there is a need to find alternative means for the control of these parasites. We screened crude extracts from 37 species of Australian native plants for their anthelmintic activity in vitro against cyathostomin larvae (development from egg to third larval stage), with the aim of identifying those species that may be suitable for incorporation into sustainable parasite management programs. Water extracts from seven species, namely Acacia baileyana, Acacia melanoxylon, Acacia podalyriifolia, Alectryon oleifolius, Duboisia hopwoodii, Eucalyptus gomphocephala and Santalum spicatum completely inhibited larval development (100% inhibition compared to the control), while another 10 species caused 90% inhibition at the initial screening concentration of 1400 ?g of extractable solids/mL. The seven most potent extracts produced IC50 values (concentration of extract which resulted in a 50% inhibition of development) in the range 30.9-196 ?g/mL. Fourteen extracts were incubated with polyvinylpolypyrrolidone (PVPP) before the assays, which removed the anthelmintic activity from 12 of these extracts, indicating that tannins were likely to be the bioactive compound responsible for the effect, while in two species, i.e. A. melanoxylon and D. hopwoodii, compounds other than tannins were likely to be responsible for their anthelmintic action. Our results suggest that a number of Australian native plants have significant anthelmintic activity against cyathostomin larval development in vitro. There is potential for these plants to be used as part of sustainable parasite control programs in horses, although more research is needed to identify the compounds responsible for the anthelmintic effects and confirm their activity in vivo. PMID:23394801

Payne, S E; Kotze, A C; Durmic, Z; Vercoe, P E

2013-09-01

314

Periostin shows increased evolutionary plasticity in its alternatively spliced region  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract Background Periostin (POSTN is a secreted extracellular matrix protein of poorly defined function that has been related to bone and heart development as well as to cancer. In human and mouse, it is known to undergo alternative splicing in its C-terminal region, which is devoid of known protein domains. Differential expression of periostin, sometimes of specific splicing isoforms, is observed in a broad range of human cancers, including breast, pancreatic, and colon cancer. Here, we combine genomic and transcriptomic sequence data from vertebrate organisms to study the evolution of periostin and particularly of its C-terminal region. Results We found that the C-terminal part of periostin is markedly more variable among vertebrates than the rest of periostin in terms of exon count, length, and splicing pattern, which we interpret as a consequence of neofunctionalization after the split between periostin and its paralog transforming growth factor, beta-induced (TGFBI. We also defined periostin's sequential 13-amino acid repeat units - well conserved in teleost fish, but more obscure in higher vertebrates - whose secondary structure is predicted to be consecutive beta strands. We suggest that these beta strands may mediate binding interactions with other proteins through an extended beta-zipper in a manner similar to the way repeat units in bacterial cell wall proteins have been reported to bind human fibronectin. Conclusions Our results, obtained with the help of the increasingly large collection of complete vertebrate genomes, document the evolutionary plasticity of periostin's C-terminal region, and for the first time suggest a basis for its functional role.

Hoersch Sebastian

2010-01-01

315

Showing that you care: the evolution of health altruism.  

Science.gov (United States)

Human behavior regarding medicine seems strange; assumptions and models that seem workable in other areas seem less so in medicine. Perhaps, we need to rethink the basics. Toward this end, I have collected many puzzling stylized facts about behavior regarding medicine, and have sought a small number of simple assumptions which might together account for as many puzzles as possible. The puzzles I consider include a willingness to provide more medical than other assistance to associates, a desire to be seen as so providing, support for nation, firm, or family provided medical care, placebo benefits of medicine, a small average health value of additional medical spending relative to other health influences, more interest in public that private signals of medical quality, medical spending as an individual necessity but national luxury, a strong stress-mediated health status correlation, and support for regulating health behaviors of the low status. These phenomena seem widespread across time and cultures. I can explain these puzzles moderately well by assuming that humans evolved deep medical habits long ago in an environment where people gained higher status by having more allies, honestly cared about those who remained allies, were unsure who would remain allies, wanted to seem reliable allies, inferred such reliability in part based on who helped who with health crises, tended to suffer more crises requiring non-health investments when having fewer allies, and invested more in cementing allies in good times in order to rely more on them in hard times. These ancient habits would induce modern humans to treat medical care as a way to show that you care. Medical care provided by our allies would reassure us of their concern, and allies would want you and other allies to see that they had pay enough to distinguish themselves from posers who didn't care as much as they. Private information about medical quality is mostly irrelevant to this signaling process. If people with fewer allies are less likely to remain our allies, and if we care about them mainly assuming they remain our allies, then we want them to invest more in health than they would choose for themselves. This tempts us to regulate their health behaviors. This analysis suggests that the future will continue to see robust desires for health behavior regulation and for communal medical care and spending increases as a fraction of income, all regardless of the health effects of these choices. PMID:17923332

Hanson, Robin

2008-01-01

316

Dizer-mostrar o estranho / Saying-showing strangeness  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese Este trabalho explora a vitalidade contemporânea de duas enfáticas vozes do século XX: Ludwig Wittgenstein e Samuel Beckett. Consideram-se em especial as seguintes divisas: de Wittgenstein, nada está oculto (Investigações, § 435); de Beckett, nada a expressar (Três diálogos com George Duthuit, I). O [...] dito de Wittgenstein é muitas vezes tomado como marca de renúncia à distinção, por ele antes sustentada, entre aquilo que se pode dizer e aquilo que apenas se mostra (Tractatus, Prefácio, 6.522). O dito de Beckett é, por sua vez, frequentemente visto como indício de uma visão cética da linguagem, que a condena a uma espécie de maldição da autorreferência. Tais formas de ler tendem a se ligar às percepções, bastante disseminadas, de que Wittgenstein escreve o comum (o "ordinário"); e Beckett, o absurdo. Questiono aspectos dessas duas produtivas leituras, sustentando que, de forma a meu ver um pouco debilitante, elas tendem a ignorar, ou talvez a apaziguar, um estranho que insiste em se dizer-mostrar na prosa poética dos dois autores. Abstract in english This paper explores the contemporary strength of two of last century's most emphatic voices: Ludwig Wittgenstein and Samuel Beckett. The following mottos are brought together with special attention: nothing is hidden, by Wittgenstein (Philosophical Investigations, §435); and nothing to express, by B [...] eckett (Three dialogues with Georges Duthuit, I). Wittgenstein's saying is frequently taken as indication that he renounces his earlier distinction between what can be said and what can only be shown (Tractatus, Preface, 6.522). Beckett's saying is, in turn, often seen as evidence of a skeptical take on language, whereas it is, so to speak, doomed to self-reference. These interpretations tend to be linked to the widespread perceptions that Wittgenstein writes the ordinary, whereas Beckett writes the absurd. I question some aspects of these two productive readings, arguing that, in a somewhat debilitating manner, they tend to ignore, or perhaps pacify, a strangeness that insists in saying-showing itself in the poetic prose of both authors.

Helena, Martins.

317

Anger, Cognition, Ideology: What Crash Can Show Us About Emotion  

Directory of Open Access Journals (Sweden)

Full Text Available

Abstract (E: Sue J. Kim’s essay “Anger, Cognition, Ideology: What Crash Can Show Us About Emotion” argues for the relevance and importance of cognitive studies to ethnic and postcolonial literary studies, and vice versa. After surveying recent developments in the field of cognitive studies, the essay combines cultural and cognitive approaches in order to examine anger in and around the 2005 Paul Haggis film Crash.

 

Abstract (F: Dans cet article, l’auteur fait un plaidoyer pour l’application des études cognitives aux études ethniques et postcoloniales et inversement. L’essai présente d’abord un survol des récents développements dans le domaine des études cognitives, puis combine les approches culturelles et cognitives dans une lecture détaillée du thème de la colère dans le film Crash de Paul Haggis (2005.

 

Sue J. Kim

2010-06-01

318

[Differential diagnostics of stomach contents showing blue discoloration].  

Science.gov (United States)

A 42-year-old man evidently had died from an intoxication. On the basis of the findings at scene it was primarily assumed that the man had ingested a larger quantity of an ethylene glycol-containing antifreeze for suicidal purposes. The man was said to have had an alcohol problem and did not only consume drinking alcohol, but also other alcoholic liquids. At autopsy, a bluish liquid with an aromatic smell was found in the oesophagus and stomach. However, toxicological analyses did not furnish evidence of ethylene glycol--as expected--but a potentially fatal concentration of ethanol (blood alcohol concentration 4.01 per mille). The blue colour (patent blue C.I.42051) came from a liquid used in the wind-screen washer system in winter, which now contains ethanol (denatured with 2-butanone) instead of ethylene glycol. The results of the toxicological findings including the analysis of congener alcohols and the differential diagnostics of blue-coloured stomach contents are discussed. PMID:21404548

Nadjem, Hadi; Perdekamp, Markus Grosse; Auwärter, Volker; Stefan, Pollak; Thierauf, Annette

2011-01-01

319

Oklahoma Cherokee formation study shows benefits of gas tax credits  

International Nuclear Information System (INIS)

To no one's surprise, the administration's recently released energy initiative package does not advocate the use of tax incentives such as the Internal Revenue Code Sec. 29 (tight sand gas) credit that expired Dec. 31, 1992. This is unfortunate since tax credits do stimulate drilling, as the authors' recent study of Oklahoma's Pennsylvanian age Cherokee formation demonstrates. Within this 783,000 acre study area, more than 130 additional wells were drilled between 1991--92 because of tax credit incentives. And such tax credits also increase total federal tax revenues by causing wells to be drilled that would not have been drilled or accelerating the drilling of wells, thereby increasing taxable revenue. In short, tax credits create a win-win situation: they stimulate commerce, increase tax revenues, reduce the outflow of capital to foreign petroleum projects, and add to the nation's natural gas reserve, which is beneficial for national security, balance of payments, the environment, and gas market development. The paper discusses the study assumptions, study results, and the tax credit policy

320

Genetic Data Showing Evolutionary Links between Leishmania and Endotrypanum  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: English Abstract in english Striking similarities at the morphological, molecular and biological levels exist between many trypanosomatids isolated from sylvatic insects and/or vertebrate reservoir hosts that make the identification of medically important parasites demanding. Some molecular data have pointed to the relationshi [...] p between some Leishmania species and Endotrypanum, which has an important epidemiological significance and can be helpful to understand the evolution of those parasites. In this study, we have demonstrated a close genetic relationship between Endotrypanum and two new leishmanial species, L. (V.) colombiensis and L. (V.) equatorensis. We have used (a) numerical zymotaxonomy and (b) the variability of the internal transcribed spacers of the rRNA genes to examine relationships in this group. The evolutionary trees obtained revealed high genetic similarity between L. (V.) colombiensis, L. (V.) equatorensis and Endotrypanum, forming a tight cluster of parasites. Based on further results of (c) minicircle kDNA heterogeneity analysis and (d) measurement of the sialidase activity these parasites were also grouped together.

Elisa, Cupolillo; Luiza OR, Pereira; Octávio, Fernandes; Marcos P, Catanho; Júlio C, Pereira; Enrique, Medina-Acosta; Gabriel, Grimaldi Jr.

1998-09-01

 
 
 
 
321

Chromatin decondensed by acetylation shows an elevated radiation response  

International Nuclear Information System (INIS)

V-79 Chinese hamster lung fibroblasts exposed to 5 mM n-sodium butyrate were irradiated with 60Co gamma rays and cell survival was determined by the cell colony assay. In a separate set of experiments the acetylated chromatin obtained from these cells was irradiated and the change of molecular weight of the DNA was evaluated by alkaline sucrose density centrifugation. At a survival level of 10(-2) to 10(-4) cells exposed to butyrate were found to be 1.3-1.4 times more radiosensitive than control cells. Exposure of isolated chromatin to 100 Gy of 60Co gamma irradiation generated 0.9 +/- 0.03 single-strand breaks (ssb) per 10 Gy per 10(8) Da and 2.0 +/- 0.3 ssb/10 Gy/10(8) Da for control and acetylated chromatin, respectively. The elevated radiation sensitivity of chromatin relaxed by acetylation is in good agreement with previous results on chromatin expanded by histone H1 depletion. Packing and accessibility of DNA in chromatin appear to be major factors which influence the radiation sensitivity. The intrinsic radiation sensitivity of chromatin in various packing states is discussed in light of the variation of radiation sensitivity of whole cells in the cell cycle which incorporates repair

322

Genetic Data Showing Evolutionary Links between Leishmania and Endotrypanum  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: English Abstract in english Striking similarities at the morphological, molecular and biological levels exist between many trypanosomatids isolated from sylvatic insects and/or vertebrate reservoir hosts that make the identification of medically important parasites demanding. Some molecular data have pointed to the relationshi [...] p between some Leishmania species and Endotrypanum, which has an important epidemiological significance and can be helpful to understand the evolution of those parasites. In this study, we have demonstrated a close genetic relationship between Endotrypanum and two new leishmanial species, L. (V.) colombiensis and L. (V.) equatorensis. We have used (a) numerical zymotaxonomy and (b) the variability of the internal transcribed spacers of the rRNA genes to examine relationships in this group. The evolutionary trees obtained revealed high genetic similarity between L. (V.) colombiensis, L. (V.) equatorensis and Endotrypanum, forming a tight cluster of parasites. Based on further results of (c) minicircle kDNA heterogeneity analysis and (d) measurement of the sialidase activity these parasites were also grouped together.

Elisa, Cupolillo; Luiza OR, Pereira; Octávio, Fernandes; Marcos P, Catanho; Júlio C, Pereira; Enrique, Medina-Acosta; Gabriel, Grimaldi Jr.

323

Asia-Pacific area shows big gains in processing  

International Nuclear Information System (INIS)

This paper reports on the Asia-Pacific region's buoyant refining and petrochemical industries that are reacting to lessons from the Persian gulf war. First-and least palatable-is the knowledge there is no alternative to oil from the Middle East to fuel headlong economic growth. Iraq's Aug. 2, 1990, invasion of Kuwait, resulting in the loss of crude oil from both countries and the flow of products from Kuwait's sophisticated refining complexes, hammered home another valuable lesson. In a crisis, the petroleum industry-oil exporting countries in particular-will in the short term find it easier to make substitute crude supplies available than to conjure up products from alternative processing capacity. The Japanese, as might be expected, are implementing new policies to take account of this lesson. Japan's tightly controlled refining sector has been told it can expand capacity for the first time in 18 years. And, with the blessing of the Japanese government, a group of companies led by Nippon Oil has agreed to a joint venture with Saudi Arabian Oil Co. that will lead to new refining capacity in Japan and a new export refinery in Saudi Arabia that is likely to be dedicated to the Japanese market

324

Video game players show more precise multisensory temporal processing abilities.  

Science.gov (United States)

Recent research has demonstrated enhanced visual attention and visual perception in individuals with extensive experience playing action video games. These benefits manifest in several realms, but much remains unknown about the ways in which video game experience alters perception and cognition. In the present study, we examined whether video game players' benefits generalize beyond vision to multisensory processing by presenting auditory and visual stimuli within a short temporal window to video game players and non-video game players. Participants performed two discrimination tasks, both of which revealed benefits for video game players: In a simultaneity judgment task, video game players were better able to distinguish whether simple visual and auditory stimuli occurred at the same moment or slightly offset in time, and in a temporal-order judgment task, they revealed an enhanced ability to determine the temporal sequence of multisensory stimuli. These results suggest that people with extensive experience playing video games display benefits that extend beyond the visual modality to also impact multisensory processing. PMID:20436205

Donohue, Sarah E; Woldorff, Marty G; Mitroff, Stephen R

2010-05-01

325

Magainin 2 induces bacterial cell death showing apoptotic properties.  

Science.gov (United States)

Magainin 2 is pore-forming antimicrobial peptide on lipid matrix of bacterial membrane, secreted from the skin of the African clawed frog Xenopus laevis. The aim of this study was to investigate a new concept for antibacterial mechanisms called bacterial apoptosis-like cell death. We examined the morphological changes induced by magainin 2 in Escherichia coli, regarding apoptosis. Specifically, phosphatidylserine externalization from the inner to outer membrane surface was detected by Annexin V staining, and DNA fragmentation and chromatin condensation was detected by TUNEL and DAPI assay. We also found much mechanistic evidence to support the hypothesis that magainin 2 induces bacterial apoptosis-like death-including disturbance of membrane detected by DiBAC4(3), caspase activation observed by FITC-VAD-FMK staining, and analyzing the role of RecA in bacterial apoptosis-like death through the RecA expression assay by Western blot-in E. Coli when treated with magainin 2. On the basis of these results, magainin 2 exerts antibacterial activity with a new mechanism which is bacterial apoptosis-like death. Searching antimicrobial agents with novel mechanisms of action can be an effective strategy to coping with the emergence of new resistance mechanisms. Magainin 2 deserves further research as a potential antimicrobial therapeutic agent. PMID:25023640

Lee, Wonyoung; Lee, Dong Gun

2014-12-01

326

Schizophrenia shows a unique metabolomics signature in plasma  

Science.gov (United States)

Schizophrenia is a severe complex mental disorder affecting 0.5–1% of the world population. To date, diagnosis of the disease is mainly based on personal and thus subjective interviews. The underlying molecular mechanism of schizophrenia is poorly understood. Using targeted metabolomics we quantified and compared 103 metabolites in plasma samples from 216 healthy controls and 265 schizophrenic patients, including 52 cases that do not take antipsychotic medication. Compared with healthy controls, levels of five metabolites were found significantly altered in schizophrenic patients (P-values ranged from 2.9 × 10?8 to 2.5 × 10?4) and in neuroleptics-free probands (P-values ranging between 0.006 and 0.03), respectively. These metabolites include four amino acids (arginine, glutamine, histidine and ornithine) and one lipid (PC ae C38:6) and are suggested as candidate biomarkers for schizophrenia. To explore the genetic susceptibility on the associated metabolic pathways, we constructed a molecular network connecting these five aberrant metabolites with 13 schizophrenia risk genes. Our result implicated aberrations in biosynthetic pathways linked to glutamine and arginine metabolism and associated signaling pathways as genetic risk factors, which may contribute to patho-mechanisms and memory deficits associated with schizophrenia. This study illustrated that the metabolic deviations detected in plasma may serve as potential biomarkers to aid diagnosis of schizophrenia. PMID:22892715

He, Y; Yu, Z; Giegling, I; Xie, L; Hartmann, A M; Prehn, C; Adamski, J; Kahn, R; Li, Y; Illig, T; Wang-Sattler, R; Rujescu, D

2012-01-01

327

Global Uranium Supply Ensured for Long Term, New Report Shows  

International Nuclear Information System (INIS)

Full text: Uranium resources and production are on the rise with the security of uranium supply ensured for the long term, according to a new report by the OECD Nuclear Energy Agency (NEA) and the International Atomic Energy Agency (IAEA). Uranium 2011: Resources, Production and Demand, commonly referred to as the ''Red Book'', shows that total identified uranium resources have grown 12.5% since 2008. However, the costs of production have also increased, leading to reductions in lower cost category resources. These figures, which reflect the situation as of 1 January 2011, mean that total identified resources are sufficient for over 100 years of supply based on current requirements. Global uranium mine production increased by over 25% between 2008 and 2010 because of significantly increased production in Kazakhstan, currently the world's leading producer. The increased resource base has been achieved thanks to a 22% increase in uranium exploration and mine development expenditures between 2008 and 2010, which in 2010 totalled over $2 billion. Demand for uranium is expected to continue to rise for the foreseeable future. Although the Fukushima Daiichi nuclear accident has affected nuclear power projects and policies in some countries, nuclear power remains a key part of the global energy mix. Several governments have plans for new nuclear power plant construction, with the strongest expansion expected in China, India, the Republic of Korea and the Russian Federation. The speed and magnitude of growth in generating capacity elsewhere is still to be determined. By the year 2035, according to the joint NEA-IAEA Secretariat, world nuclear electricity generating capacity is projected to grow from 375 GWe net (at the end of 2010) to between 540 GWe net in the low demand case and 746 GWe net in the high demand case, increases of 44% and 99% respectively. Accordingly, world annual reactor-related uranium requirements are projected to rise from 63 875 tonnes of uranium metal (tU) at the end of 2010 to between 98 000 tU and 136 000 tU by 2035. The currently defined uranium resource base is more than adequate to meet high-case requirements through 2035 and well into the foreseeable future. Although ample resources are available, meeting projected demand will require timely investments in uranium production facilities. This is because of the long lead times (typically in the order of ten years or more in most producing countries) required to develop production facilities that can turn resources into refined uranium ready for nuclear fuel production. With uranium production ready to expand to new countries, efforts are being made to develop transparent and well-regulated operations similar to those used elsewhere to minimise potential environmental and local health impacts. Although not the primary focus of the Red Book, activity updates on the environmental aspects of the uranium production cycle are included in the national reports in this edition. While the status of supply and demand is considered from the perspective of technologies in use today, the deployment of advanced reactors and fuel cycle technologies can also positively affect the long-term availability of uranium, conceivably extending the time horizon of the currently defined resource base to thousands of years. These are some of the findings in the just-published Uranium 2011: Resources, Production and Demand, a joint study by the OECD/NEA and the IAEA, carried out in co-operation with their member countries. This is the 24th edition of this periodic assessment (currently every two years) which has been published since the mid-1960s. (IAEA)

328

Energetic radiation belt electron precipitation showing ULF modulation  

Science.gov (United States)

The energization and loss processes for energetic radiation belt electrons are not yet well understood. Ultra Low Frequency (ULF) waves have been correlated with both enhancement in outer zone radiation belt electron flux and modulation of precipitation loss to the atmosphere. This study considers the effects of ULF waves in the Pc-4 to Pc-5 range on electron loss to the atmosphere on a time scale of several minutes. Global simulations using magnetohydrodynamics (MHD) model fields as drivers provide a valuable tool for studying the dynamics of these ˜MeV energetic particles. ACE satellite measurements of the MHD solar wind parameters are used as the upstream boundary condition for the Lyon-Fedder-Mobarry (LFM) 3D MHD code calculation of fields, used to drive electrons in a 3D test particle simulation that keeps track of attributes like energy, pitch-angle and L-shell. The simulation results are compared with balloon observations obtained during the January 21, 2005 CME-shock event. Rapid loss of 20~keV to 1.5~MeV electrons was detected by balloon-borne measurements of Bremsstrahlung X-rays during the MINIS balloon campaign following the shock arrival at Earth. The global response of the radiation belts to this particular CME-shock driven storm was investigated focusing on precipitation mechanisms by which ULF waves, seen both in the simulations and observations influence the radiation belt population. A primary cause for the precipitation modulation seen in both the simulation and the MINIS campaign is suggested based on the lowering of mirror points due to compressional magnetic field oscillations.

Brito, T. V.; Hudson, M. K.; Kress, B. T.

2012-12-01

329

What Makes the Difference? Pop Music Stars and TV Talent Show Contestants in Adolescents' Judgements  

Digital Repository Infrastructure Vision for European Research (DRIVER)

This paper summarises the approach, empirical methodologies, and part of the results of an empirical study that was conducted in early 2004, when musical TV talent shows reached their peak popularity among young media audiences in Germany. Our primary research interest was in the similarities and differences that the adolescent target group of this TV format might perceive between contestants in TV talent shows and real or ordinary pop music stars. Shows in this TV format all seem to...

Lothwesen, Kai; Mullensiefen, Daniel

2005-01-01

330

New Drug Regimen Shows Clear Benefit for Treating Advanced Colorectal Cancer  

Science.gov (United States)

Initial results from a large, randomized clinical trial for patients with advanced colorectal cancer show that those who received a regimen containing the investigational drug oxaliplatin lived months longer than those who received a standard therapy.

331

Two cases of Tolosa-Hunt syndrome showing interesting CT findings  

International Nuclear Information System (INIS)

CT showed the lesion at the orbital apex in both of the 2 cases of Tolosa-Hunt syndrome. Steroid therapy resulted in improvement of clinical symptoms and regression of the lesion which was confirmed by CT. (Chiba, N.)

332

Comparison of transition temperature shifts from static and dynamic tests  

International Nuclear Information System (INIS)

Paper summarizes results of surveillance specimens programmes of WWER-440/V-213C type reactors. Comparison of transition temperature shifts, induced by irradiation, and determined from impact Charpy V-notch toughness as well as from static fracture toughness tests on pre-cracked Charpy size specimens (COD) is given. Two methods have been used for determination of static fracture toughness shifts - standard COD type specimens from a standard surveillance programmes and reconstituted COD type specimens from broken halves of Charpy V-notch specimens. Results obtained are discussed from the point of view of irradiation conditions as well as of different type of testing. (author)

333

Local approach of the Charpy test at low temperature  

Energy Technology Data Exchange (ETDEWEB)

Charpy V-notch impact testing is widely used in the toughness assessment of large forged components, e.g. the pressure vessel for pressurised water reactors (PWR). At low temperature, A508 Cl.3 nuclear pressure vessel steel fails by cleavage fracture. The results reported here are part of both an experimental program and numerical investigations which aim at the establishment of a non-empirical relationship between the lower shelf Charpy V-notch energy, CVN, and the fracture toughness, K{sub Ic}, of this material. Here, the applicability of the Beremin cleavage fracture model to the Charpy specimen is demonstrated. (orig.).

Rossoll, A. [Ecole Centrale de Paris, Chatenay-Malabry (France). Lab. MSS-MAT; Tahar, M. [Ecole Centrale de Paris, Chatenay-Malabry (France). Lab. MSS-MAT]|[Ecole des Mines de Paris, Centre des Materiaux, Evry (France); Berdin, C. [Ecole Centrale de Paris, Chatenay-Malabry (France). Lab. MSS-MAT; Piques, R. [Ecole Centrale de Paris, Chatenay-Malabry (France). Lab. MSS-MAT]|[Ecole des Mines de Paris, Centre des Materiaux, Evry (France); Forget, P. [Ecole Centrale de Paris, Chatenay-Malabry (France). Lab. MSS-MAT]|[CEA Saclay, CEREM, SRMA, Gif-sur-Yvette (France); Prioul, C. [Ecole Centrale de Paris, Chatenay-Malabry (France). Lab. MSS-MAT; Marini, B. [Ecole Centrale de Paris, Chatenay-Malabry (France). Lab. MSS-MAT]|[CEA Saclay, CEREM, SRMA, Gif-sur-Yvette (France)

1996-10-01

334

Local approach of the Charpy test at low temperature  

International Nuclear Information System (INIS)

Charpy V-notch impact testing is widely used in the toughness assessment of large forged components, e.g. the pressure vessel for pressurised water reactors (PWR). At low temperature, A508 Cl.3 nuclear pressure vessel steel fails by cleavage fracture. The results reported here are part of both an experimental program and numerical investigations which aim at the establishment of a non-empirical relationship between the lower shelf Charpy V-notch energy, CVN, and the fracture toughness, KIc, of this material. Here, the applicability of the Beremin cleavage fracture model to the Charpy specimen is demonstrated. (orig.)

335

Local Approach of the Charpy Test at Low Temperature  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Charpy V-notch impact testing is widely used in the toughness assessment of large forged components, e.g. the pressure vessel for pressurised water reactors (PWR). At low temperature, A508 Cl.3 nuclear pressure vessel steel fails by cleavage fracture. The results reported here are part of both an experimental program and numerical investigations which aim at the establishment of a non-empirical relationship between the lower shelf Charpy V-notch energy, CVN, and the fracture toughness, KIc, o...

Rossoll, A.; Tahar, M.; Berdin, C.; Piques, R.; Forget, P.; Prioul, C.; Marini, B.

1996-01-01

336

Thermotropic luminescent clustomesogen showing a nematic phase: a combination of experimental and molecular simulation studies.  

Science.gov (United States)

Octahedral Mo6 nanoclusters are functionalized with two organic ligands containing cyanobiphenyl (CB) units, giving luminescent hybrid liquid crystals (LC). Although the mesogenic density around the bulky inorganic core is constant, the two hybrids show different LC properties. Interestingly, one of them shows a nematic phase, which is particularly rare for this kind of supermolecular system. This surprising result is explained by using large-scale molecular dynamic simulations. PMID:24898404

Cortes, Maria Amela; Dorson, Frederick; Prévôt, Marianne; Ghoufi, Aziz; Fontaine, Bruno; Goujon, Florent; Gautier, Régis; Cîrcu, Viorel; Mériadec, Cristelle; Artzner, Franck; Folliot, Hervé; Cordier, Stéphane; Molard, Yann

2014-07-01

337

CT and US findings of abdominal tuberculosis: Showing mainly extrainterestinal lesions  

Energy Technology Data Exchange (ETDEWEB)

Pathologically proven 15 cases of abdominal tuberculous mainly located at extraintestinal area during recent 3 years were reviewed retrospectively. The results were as follows: 1. Of total 15 cases were males and 10 cases females. And 7 cases of 15 were among third decades. 2. Total 15 cases of chest x-ray; 4 cases showed pulmonary tuberculous, 2 cases, pleural effusions, and 9 cases, normal, 10 cases of G-I barium study or colonospecic examination showed 2 intestinal tuberculous and 8 normal states. 3. Pattern of abdominal tuberculous mainly located at extraintestinal area according to CT and US findings: 1) 6 cases showed multiple lymphadenopathy on mesentery, paraaortic area, peripancreatic area, gastrohepatic ligament or esophagogastric junction. 2) 6 cases showed abscess formation pattern on inguinal area, retropublic area of abdominal wall, iliopsoas muscle area, abdominal wall and adjacent to IVC at umbilical level. 3) 3 cases showed mesenteric thickening and ascites.

Cha, Sang Hoon; Han, Chun Hee; Kim, Yun Hwan; Lee, Nam Joon; Suh, Won Hyuck [Korea University College of Medicine, Seoul (Korea, Republic of); Chung, Woun Kyun [Sungnam Hanmi Hospital, Seoul (Korea, Republic of)

1987-02-15

338

CT and US findings of abdominal tuberculosis: Showing mainly extrainterestinal lesions  

International Nuclear Information System (INIS)

Pathologically proven 15 cases of abdominal tuberculous mainly located at extraintestinal area during recent 3 years were reviewed retrospectively. The results were as follows: 1. Of total 15 cases were males and 10 cases females. And 7 cases of 15 were among third decades. 2. Total 15 cases of chest x-ray; 4 cases showed pulmonary tuberculous, 2 cases, pleural effusions, and 9 cases, normal, 10 cases of G-I barium study or colonospecic examination showed 2 intestinal tuberculous and 8 normal states. 3. Pattern of abdominal tuberculous mainly located at extraintestinal area according to CT and US findings: 1) 6 cases showed multiple lymphadenopathy on mesentery, paraaortic area, peripancreatic area, gastrohepatic ligament or esophagogastric junction. 2) 6 cases showed abscess formation pattern on inguinal area, retropublic area of abdominal wall, iliopsoas muscle area, abdominal wall and adjacent to IVC at umbilical level. 3) 3 cases showed mesenteric thickening and ascites.

339

Latest results from GAMS  

Science.gov (United States)

Some of the latest results of the GAMS Collaboration are reviewed. The f0(1590) has been observed in central collisions, adding support to its glueball nature. Evidence has been found for an exotic 1-+ meson M(1405) decaying into ?0? in the exclusive reaction ?-p ? M(1405)n at 100 GeV/c. New data are presented on the reaction ?-p ? ??n at 38 GeV/c showing the presence of two tensor mesons.

Binon, F. G.

1989-04-01

340

Consumer behavior towards show-room services of two wheelers with reference to Cuddalore district  

Directory of Open Access Journals (Sweden)

Full Text Available The study aims to find out the consumer behavior towards showroom service of two wheelers. A samples of 200 users selected randomly were studied. Standardized questionnaires were used to collect the data. The results reveal that users differ in consumer behaviour towards showroom services of two wheelers on the basis of satisfied random sampling. This study is made to describe the consumer satisfaction of two wheelers with respect to socio-economic characteristics as age, gender, occupation, family income, educational level and so on which is called descriptive study. The data were treated statistically using t-test, F-test and correlation. The result shows that students and employees are more satisfied about show room services. Demographic variables such as marital status, size of the family give significant effect related to show room services.

S.Pragadeeswaran

2009-12-01

 
 
 
 
341

University of Colorado study shows how an enzyme kills cancer cells and also speeds regrowth:  

Science.gov (United States)

When your body is injured, it signals your cells to increase their growth rate. That makes sense: damage requires speedy repair. Results from a University of Colorado study...show how cancer cells use this mechanism to repopulate after a tumor is damaged by radiotherapy; and the study offers hope for a future in which the regrowth of cancer cells is slowed.

342

Suffering by comparison: Twitter users' reactions to the Victoria's Secret Fashion Show.  

Science.gov (United States)

Social comparison theory suggests that evaluating the self in comparison with others (e.g., peers, celebrities, models) can influence body image. Experimental studies that have tested effects of viewing idealized images in the media often show that women feel worse about themselves after seeing images that illustrate the beauty ideal. Twitter presents a naturally occurring opportunity to study viewers' reactions. An analysis was conducted of 977 tweets sent immediately before and during the 2011 Victoria's Secret Fashion Show that reference the show. Although the majority were idiosyncratic remarks, many tweets contain evidence of upward social comparisons to the fashion models. There were tweets about body image, eating disorders, weight, desires for food or alcohol, and thoughts about self-harm. The results support social comparison theory, and suggest that vulnerable viewers could experience negative affect, or even engage in harmful behaviors, during or after viewing the show or others like it. PMID:23769929

Chrisler, Joan C; Fung, Kaitlin T; Lopez, Alexandra M; Gorman, Jennifer A

2013-09-01

343

Investigating CSI: portrayals of DNA testing on a forensic crime show and their potential effects.  

Science.gov (United States)

The popularity of forensic crime shows such as CSI has fueled debate about their potential social impact. This study considers CSI's potential effects on public understandings regarding DNA testing in the context of judicial processes, the policy debates surrounding crime laboratory procedures, and the forensic science profession, as well as an effect not discussed in previous accounts: namely, the show's potential impact on public understandings of DNA and genetics more generally. To develop a theoretical foundation for research on the "CSI effect," it draws on cultivation theory, social cognitive theory, and audience reception studies. It then uses content analysis and textual analysis to illuminate how the show depicts DNA testing. The results demonstrate that CSI tends to depict DNA testing as routine, swift, useful, and reliable and that it echoes broader discourses about genetics. At times, however, the show suggests more complex ways of thinking about DNA testing and genetics. PMID:22530487

Ley, Barbara L; Jankowski, Natalie; Brewer, Paul R

2012-01-01

344

Musical slide show MAF with protection and governance using MPEG-21 IPMP Components and REL  

Science.gov (United States)

The Musical Slide Show Multimedia Application Format (MAF) which is currently being standardized by the Moving Picture Expert Group (MPEG) conveys the concept of combining several established standard technologies in a single file format. It defines the format of packing up MP3 audio data, along with JPEG images, MPEG-7 Simple Profile metadata, timed text, and MPEG-4 LASeR script. The presentation of Musical Slide Show MAF contents is made in a synchronized manner with JPEG images, timed text to MP3 audio track. Also, the rendering effect on JPEG images can be supported by the MPEG-4 LASeR script. This Musical Slide Show MAF will enrich the consumption of MP3 contents assisted with synchronized and rendered JPEG images, text as well as MPEG-7 metadata about the MP3 audio contents. However, there is no protection and governance mechanism for Musical Slide Show MAF which is the essential elements to deploy the sorts of contents. In this paper, to manage the Musical Slide Show MAF contents in a controlled manner, we present a protection and governance mechanism by using MPEG-21 Intellectual Property Management and Protection (IPMP) Components and MPEG-21 Rights Expression Language (REL) technologies We implement an authoring tool and a player tool for Musical Slide Show MAF contents and show the experimental results as well.

Sabirin, Muhammad Syah Houari; Tan, Hendry; Lim, Jeongyeon; Kim, Munchurl

2007-02-01

345

Results on NN scattering  

International Nuclear Information System (INIS)

Recent measurements in NN ? NN scattering are reviewed. In pp elastic scattering at intermediate energies measurements of the differential cross-section have been performed at FNAL. New results in the charge-exchange pp-nn reaction have been obtained from LEAR experiments, which have measured both spin observables and cross-sections. These data constitute an important piece of information to fix the parameters of the theoretical models and to determine their limits of validity. The precise measurements of the pp ? nn differential cross-section show clearly the contribution of the ?-exchange and have allowed a novel determination of the value of the ?NN coupling constant. (orig.)

346

BIOMETRICAL ANALYSIS OF ARABIAN FOALS AND THEIR LATER SUCCESSES IN SHOWS AND ON RACE TRACK  

Directory of Open Access Journals (Sweden)

Full Text Available Arabian horses are one of the most important products of Polish horse breeding.Many of them are International and World champions in shows; others are very wellknown as courageous race horses. To obtain such champions it is necessary to takeunder consideration many factors affecting the final results. The objective of thisstudy was to evaluate the effect of biometrical measurements of the foals at birthaccording to their future successes in shows and on racetrack. The study was carriedout on 143 horses winning in shows and in races. Body weight, height at withers,girth and canon circumferences taken at birth of these horses were analysed.Additionally coat colour was studied. All studied animals were divided into threegroups according to each measurement and the differences between such groupswere evaluated according points obtained for particular place at shows and place inraces. It was stated that horses heavier at birth and with higher girth circumferencegot more successes both at shows and on racetrack. Horses with higher height atwithers at birth were more successful in shows while animals with higher canoncircumference won oftener at race track. It was observed that the most courageousrace horses were bay while most champions were grey.

M. PIESZKA

2013-12-01

347

Recent results from ARGUS  

International Nuclear Information System (INIS)

Some recent results are reported from the ARGUS experiment, operated at the e+e- storage ring DORIS II at DESY. In an updated analysis of semileptonic b ? u decays direct evidence for such transitions was obtained through reconstruction of a complete event. A study of the lepton energy spectra in ?- ? e- ? bar ? and ?- ? ? ? bar ? decays yielded a value for the Michel parameter which is in good agreement with a standard V - A coupling at the ?-??-W vertex. A parity violating asymmetry was measured in ? decays into three charged pions which shows that the ? neutrino has negative helicity. The Micro Vertex Drift Chamber was installed as a new hardware component of the ARGUS detector. Initial results concerning backgrounds and chamber performance are presented

348

Correlation between radiation damage and magnetic properties in reactor vessel steels  

Science.gov (United States)

Since reactor pressure vessel steels are ferromagnetic, provide a convenient means to monitor changes in the mechanical properties of the material upon irradiation with high energy particles, by measuring their magnetic properties. Here, we discuss the correlation between mechanical and magnetic properties and microstructure, by studying the flux effect on the nuclear pressure vessel steel used in reactors currently under construction in Argentina. Charpy-V notched specimens of this steel were irradiated in the RA1 experimental reactor at 275 °C with two lead factors (LFs), 93 and 183. The magnetic properties were studied by means of DC magnetometry and ferromagnetic resonance. The results show that the coercive field and magnetic anisotropy spatial distribution are sensitive to the LF and can be explained by taking into account the evolution of the microstructure with this parameter. The saturation magnetization shows a dominant dependence on the accumulated damage.

Kempf, R. A.; Sacanell, J.; Milano, J.; Guerra Méndez, N.; Winkler, E.; Butera, A.; Troiani, H.; Saleta, M. E.; Fortis, A. M.

2014-02-01

349

Adolescents with autism spectrum disorder show a circumspect reasoning bias rather than 'jumping-to-conclusions'.  

Science.gov (United States)

People with autism spectrum disorders (ASD) often take longer to make decisions. The Autism-Psychosis Model proposes that people with autism and psychosis show the opposite pattern of results on cognitive tasks. As those with psychosis show a jump-to-conclusions reasoning bias, those with ASD should show a circumspect reasoning bias. Jumping-to-conclusions was assessed in a sample of 20 adolescents with ASD and 23 age-matched controls using the jumping-to-conclusions beads task. Both groups demonstrated equivalent levels of confidence in decision-making, however the ASD group required more beads than controls before making their decision. Furthermore, there was a positive correlation between the beads required and degree of autism symptoms. Consistent with the Autism-Psychosis Model, a more circumspect reasoning bias was evident in ASD. PMID:24002414

Brosnan, Mark; Chapman, Emma; Ashwin, Chris

2014-03-01

350

Brain morphometry shows effects of long-term musical practice in middle-aged keyboard players  

Directory of Open Access Journals (Sweden)

Musicians showed a significantly better symmetric motor performance as well as a greater capability of controlling hand independence than controls. Structural MRI-data revealed significant volumetric differences between the brains of keyboard players, who practiced intensively and controls in right sensorimotor areas and the corticospinal tract as well as in the entorhinal cortex and the left superior parietal lobule. Moreover, they showed also larger volumes in a comparable set of regions than the less intensively practicing musicians. The structural changes in the sensory and motor systems correspond well to the behavioral results, and can be interpreted in terms of plasticity as a result of intensive motor training. Areas of the superior parietal lobule and the entorhinal cortex might be enlarged in musicians due to their special skills in sight-playing and memorizing of scores. In conclusion, intensive and specific musical training seems to have an impact on brain structure, not only during the sensitive period of childhood but throughout life.

HannaGärtner

2013-09-01

351

University of Pittsburgh study of peptide vaccine shows evidence of immunological response in children with gliomas  

Science.gov (United States)

Researchers from Children’s Hospital of Pittsburgh of UPMC and the University of Pittsburgh Cancer Institute (UPCI) Brain Tumor Program have demonstrated that peptide vaccines in children with gliomas, the most common type of brain tumor, not only were well-tolerated but also showed evidence of immunological responses. The results of the study were presented during a press conference at the American Association for Cancer Research Annual Meeting 2012 in Chicago.

352

Polyol-mediated C-dot formation showing efficient Tb3+/Eu3+ emission.  

Science.gov (United States)

C-dots (3-5 nm in diameter) obtained by most simple heating of polyols (glycerol, diethylene glycol and PEG 400) show intense blue and green emission (50% quantum yield). Upon modification with TbCl3/EuCl3, energy transfer from the C-dots to the rare-earth metal results in line-type Tb(3+) (green)/Eu(3+) (red) emission with quantum yields up to 85%. PMID:24887063

Dong, Hailong; Kuzmanoski, Ana; Gössl, Dorothee M; Popescu, Radian; Gerthsen, Dagmar; Feldmann, Claus

2014-07-18

353

Especialistas psi em ação: sobre a distribuição de expertises num reality show.  

Directory of Open Access Journals (Sweden)

Full Text Available O objetivo deste artigo é discutir a articulação entre as práticas dos especialistas psis e as modulações da intimidade a partir da sua exposição na mídia através do blog de um programa de televisão no formato de reality show. Foram analisados comentários dos seguidores do blog e cinco entrevistas semi-estruturadas com participantes do programa. Inspiradas em autores como Latour (2008 e Despret (2011, as pesquisadoras problematizam a distribuição da expertise a partir da análise do programa exibido no blog. Os resultados indicam que a distribuição da expertise ativa a todos que se articulam no dispositivo produzindo modos de subjetivar psicologizados. // Psi experts in action: on the distribution of expertise in a reality show. This paper aims to discuss the relationship between practices of psi experts and modulations of intimacy based on its exposure on a reality show microblog. Inspired by authors like Latour (2008 and Despret (2011, the researchers put in question the distribution of expertise in the reality show microblog. The results indicate that the distribution of expertise enables people who are articulated in the reality show enacting psychologized subjectivities.

Marcia Moraes

2014-05-01

354

No-shows to primary care appointments: subsequent acute care utilization among diabetic patients  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract Background Patients who no-show to primary care appointments interrupt clinicians’ efforts to provide continuity of care. Prior literature reveals no-shows among diabetic patients are common. The purpose of this study is to assess whether no-shows to primary care appointments are associated with increased risk of future emergency department (ED visits or hospital admissions among diabetics. Methods A prospective cohort study was conducted using data from 8,787 adult diabetic patients attending outpatient clinics associated with a medical center in Indiana. The outcomes examined were hospital admissions or ED visits in the 6?months (182?days following the patient’s last scheduled primary care appointment. The Andersen-Gill extension of the Cox proportional hazard model was used to assess risk separately for hospital admissions and ED visits. Adjustment was made for variables associated with no-show status and acute care utilization such as gender, age, race, insurance and co-morbid status. The interaction between utilization of the acute care service in the six months prior to the appointment and no-show was computed for each model. Results The six-month rate of hospital admissions following the last scheduled primary care appointment was 0.22 (s.d.?=?0.83 for no-shows and 0.14 (s.d.?=?0.63 for those who attended (p?p? Conclusions No-show to a primary care appointment is associated with increased risk for hospital admission among diabetics recently hospitalized.

Nuti Lynn A

2012-09-01

355

Task 23 -- User`s guide to GRI-ShowFlow  

Energy Technology Data Exchange (ETDEWEB)

GRI-ShowFlow is a compilation of flow and transport groundwater models under one user-friendly, graphical interface in the Microsoft{reg_sign}Windows{trademark} 3.1 environment. The groundwater models as well as the interface were derived from existing codes. The motivation behind the development of GRI-ShowFlow was twofold: (1) there is a need to compare and assess various analytical and screening-level models that are being used by regulatory agencies and (2) there is a need for the nonexpert to be able to use these screening-level models and the resulting information without expert interpretation. GRI-ShowFlow was developed for use by gas industry environmental staff who may have little experience with hydrogeology or groundwater models but must be able to quickly determine whether there is sufficient chance of groundwater contamination and whether a site does or does not require a more extensive examination. Special attention was therefore given to the Help System in GRI-ShowFlow, which aids the development of the minimal amount of data required by the program and the interpretation of the resulting data. The objective of GRI-ShowFlow is to bring together the existing EPA models in a user-friendly environment and to compare them to each other as well as to new models that contain analytical solutions to three-dimensional source descriptions. A three-dimensional body will more closely reflect the shapes of contaminant sources than one- or two-dimensional geometries. In the real world, contamination sources such as landfills, storage pits, and lagoons will, after all, occupy a three-dimensional space.

NONE

1997-03-01

356

VRAC: Simulation Results #1  

CERN Document Server

In order to make full use of geographic routing techniques developed for large scale networks, nodes must be localized. However, localization and virtual localization techniques in sensor networks are dependent either on expensive and sometimes unavailable hardware (e.g. GPS) or on sophisticated localization calculus (e.g. triangulation) which are both error-prone and with a costly overhead. Instead of localizing nodes in a traditional 2-dimensional space, we use directly the raw distance to a set of anchors to route messages in a multi-dimensional space. This should enable us to use any geographic routing protocol in a robust and efficient manner in a very large range of scenarios. We test this technique for two different geographic routing algorithms, namely GRIC and ROAM. The simulation results show that using the raw coordinates does not decrease their efficiency.

Huc, Florian

2009-01-01

357

Drugs developed for treatment of diabetes show protective effects in Alzheimer's and Parkinson's diseases.  

Science.gov (United States)

Type 2 diabetes has been identified as a risk factor for Alzheimer's disease (AD) and Parkinson's disease (PD). In the brains of patients with AD and PD, insulin signaling is impaired. This finding has motivated new research that showed good effects using drugs that initially had been developed to treat diabetes. Preclinical studies showed good neuroprotective effects applying insulin or long lasting analogues of incretin peptides. In transgenic animal models of AD or PD, analogues of the incretin GLP-1 prevented neurodegenerative processes and improved neuronal and synaptic functionality and reduced the symptoms of the diseases. Amyloid plaque load and synaptic loss as well as cognitive impairment had been prevented in transgenic AD mouse models, and dopaminergic loss of transmission and motor function has been reversed in animal models of PD. On the basis of these promising findings, several clinical trials are being conducted with the first encouraging clinical results already published. In several pilot studies in AD patients, the nasal application of insulin showed encouraging effects on cognition and biomarkers. A pilot study in PD patients testing a GLP-1 receptor agonist that is currently on the market as a treatment for type 2 diabetes (exendin-4, Byetta) also showed encouraging effects. Several other clinical trials are currently ongoing in AD patients, testing another GLP-1 analogue that is on the market (liraglutide, Victoza). Recently, a third GLP-1 receptor agonist has been brought to the market in Europe (Lixisenatide, Lyxumia), which also shows very promising neuroprotective effects. This review will summarise the range of these protective effects that those drugs have demonstrated. GLP-1 analogues show promise in providing novel treatments that may be protective or even regenerative in AD and PD, something that no current drug does. PMID:25331995

Hölscher, Christian

2014-10-25

358

Uma aproximação analí­tica do formato televisual do reality show Big Brother  

Directory of Open Access Journals (Sweden)

Full Text Available O trabalho apresenta alguns resultados de uma pesquisa comparada sobre o funcionamento semiótico de um formato televisivo global em duas de suas produções locais, Rio de la Plata e Brasil, nos anos 2001 e 2002. Através da perspectiva sociossemiótica baseada no modelo de Peirce, procura-se analisar os elementos próprios da significação do formato e de sua contextualização local. Descreve-se o reality show Big Brother como uma melocrônica dos bastidores da interação humana, em atenção aos componentes sí­gnicos centrais do formato, isto é, í­ndices e í­cones, que emergem na encenação televisual do face a face cotidiano. A contemplação turí­stica da ordem de interação ou do âmbito da sociabilidade permite compreender mudanças nas formas sociais que vão muito além do reduzido espaço do reality show glocal da Endemol, p.ex. no discurso eleitoral televisivo brasileiro. Palavras chave reality show, semiótica triádica, gênero hí­brido, sociabilidade. Abstract The article presents some results of a comparative research on the semiotic functioning of a global television genre in two of its local productions, that of the River Plate and that of Brazil, in the years 2001 and 2002. Through a sociosemiotic perspective based on the model of C. S. Peirce, the text accounts for the specific elements of signification of the format and of its local contextualization. The Big Brother reality show is deemed to be a hybrid genre, namely, a melochronicle of the backstage of human interaction, on account of the basic sign components of this TV format, i.e., indexes and icons, which emerge in the televisual staging of everyday face to face encounters. A tourist-like contemplation of the order of interaction or sociability realm allows us to understand changes in the social forms that reach far beyond the limited realm of the glocal Endemol reality show, for instance, in the Brazilian television political campaign. Key words reality show; triadic semiotic; hybrid genre; social interaction.

Fernando Andacht

2008-11-01

359

Alzheimer's-associated A? oligomers show altered structure, immunoreactivity and synaptotoxicity with low doses of oleocanthal  

International Nuclear Information System (INIS)

It now appears likely that soluble oligomers of amyloid-?1-42 peptide, rather than insoluble fibrils, act as the primary neurotoxin in Alzheimer's disease (AD). Consequently, compounds capable of altering the assembly state of these oligomers (referred to as ADDLs) may have potential for AD therapeutics. Phenolic compounds are of particular interest for their ability to disrupt A? oligomerization and reduce pathogenicity. This study has focused on oleocanthal (OC), a naturally-occurring phenolic compound found in extra-virgin olive oil. OC increased the immunoreactivity of soluble A? species, when assayed with both sequence- and conformation-specific A? antibodies, indicating changes in oligomer structure. Analysis of oligomers in the presence of OC showed an upward shift in MW and a ladder-like distribution of SDS-stable ADDL subspecies. In comparison with control ADDLs, oligomers formed in the presence of OC (A?-OC) showed equivalent colocalization at synapses but exhibited greater immunofluorescence as a result of increased antibody recognition. The enhanced signal at synapses was not due to increased synaptic binding, as direct detection of fluorescently-labeled ADDLs showed an overall reduction in ADDL signal in the presence of OC. Decreased binding to synapses was accompanied by significantly less synaptic deterioration assayed by drebrin loss. Additionally, treatment with OC improved antibody clearance of ADDLs. These results indicate oleocanthal is capable of altering the oligomerization state of ADDLs while protecting neurons from the synaptopathological effects of ADDLs and suggest OC as a lead compound for development in AD therapeutics.

360

School-Aged Children and Adult Language Production in an Indonesian TV Show  

Directory of Open Access Journals (Sweden)

Full Text Available The aim of this research was to find out the language produced by the school-aged children and the adult in a TV show. The study was carried out applying descriptive qualitative research design. The data for this research included the conversations between an adult (the host and three school-aged children. The data analysis procedures included- observing the video, transcribing the conversation, identifying the linguistics and non-linguistics features of the utterances, categorizing the language produced by the children and the adult, and interpreting the result of the analysis. The findings of data analysis showed that the five-year-old children produced one-word and two-word utterances rather than longer sentences. In contrast, the seven-year-old child produced longer sentences rather than one-word or two-word utterances. On the other hand, the host applied different ways and modified the way she produced language (‘caregiver speech’ or ‘motherese’ such as using exclamation, using gestures, using complimenting words, using intimate pronouns, and using direct instruction. The results obtained indicated that the school-aged children and the adult have their own ways in producing language in a TV show in Indonesia.

Kisno

2014-03-01

 
 
 
 
361

Verification of the effect of surface preparation on Hot Isostatic Pressing diffusion bonding joints of CLAM steel  

Science.gov (United States)

Hot Isostatic Pressing (HIP) diffusion bonding with CLAM steel is the primary candidate fabrication technique for the first wall (FW) of DFLL-TBM. Surface state is one of the key factors for the joints quality. The effect of surface state prepared with grinder and miller on HIP diffusion bonding joints of CLAM steel was investigated. HIP diffusion bonding was performed at 140 MPa and 1373 K within 3 h. The mechanical properties of the joints were investigated with instrumented Charpy V-notch impact tests and the microstructures of the joints were analyzed with scanning electron microscopy (SEM). The results showed that the milled samples with fine surface roughness were more suitable for CLAM steel HIP diffusion bonding.

Zhao, Yanyun; Li, Chunjing; Huang, Bo; Liu, Shaojun; Huang, Qunying

2014-12-01

362

Evaluating mechanical properties of hybrid laser arc girth welds  

Energy Technology Data Exchange (ETDEWEB)

Hybrid laser arc welding (HLAW) is a promising new process for making girth welds on steel pipelines. This study investigated the mechanical properties of overmatched X80 and X100 pipeline steel girth welds made using the HLAW process. The testing of this process was conducted on NPS36 pipes of 10.4 mm and 14.3 mm thickness, respectively. Various weld positions were produced on X80 and X100 pipes. Laser inspection data were collected during the whole welding process. Also standard tests for girth welds, Charpy V-notch impact tests, CTOD tests, all weld metal (AWM) tension tests, were carried out. The results showed that the fracture transition temperature is higher at the 3 and 9 o'clock positions than at the 9 and 12 o'clock positions. The effect of clock position on fracture toughness is currently being explored; a modified CTOD has been developed to reduce the possibility of crack deviation.

Pussegoda, L. N.; Begg, D.; Holdstock, R.; Jodoin, A. [BMT Fleet Technology Ltd Techonology, Kanata, ON, (Canada); Ligh, K.; Rondeau, D. [Appliead Thermal Sciences Inc., Sanford, ME, (United States); Hansen, E. [ESAB, Florence, SC, (United States)

2010-07-01

363

The effect of hydrogen on mechanical properties of oxygen-strengthened titanium  

Science.gov (United States)

The effect of oxygen on the hydrogen embrittlement in titanium was investigated in two Ti-based alloys containing different amounts of oxygen: 0.064 and 0.154, in wt pct. Tensile, impact, and hardness tests were performed with and without prior hydrogenation of the specimens. Results show that, while the presence of hydrogen, even in relatively small amounts, will not affect the hardness or room-temperature tensile properties determined at relatively slow strain rates, hydrogen will reduce significantly the impact resistance, as determined by the Charpy V-notch test. This deleterious effect on the impact resistance was found to be exacerbated by an increase of oxygen in the alloy.

Wasz, M. L.; Ko, C. C.; Brotzen, F. R.; Mclellan, R. B.

1989-01-01

364

Effect of helium implantation on mechanical properties and microstructure evolution of reduced-activation 9Cr-2W martensitic steel  

International Nuclear Information System (INIS)

A reduced-activation martensitic steel was implanted with helium up to 580 at. ppm by using 36 MeV ?-beam between 353 and 423 K along with displacement damage up to 0.226 dpa. The implantation-induced increase in ductile-brittle transition temperature (DBTT) was estimated to be 98 K for the standard charpy V-notched (CVN) specimen implanted with 580 at. ppm He, through the conversion of small punch (SP) test results by an empirical relationship. It is clarified from comparison with neutron irradiation data that the increase in DBTT as well as implantation-induced hardening is interpreted simply in terms of displacement damage, suggesting that there is no significant effect of helium on both the irradiation hardening and the fracture toughness of the steel. No fracture mode change by the helium implantation was observed in the SP tests, showing a complete cleavage fracture mode in the lower shelf energy region

365

Effect of helium implantation on mechanical properties and microstructure evolution of reduced-activation 9Cr-2W martensitic steel  

Science.gov (United States)

A reduced-activation martensitic steel was implanted with helium up to 580 at. ppm by using 36 MeV ?-beam between 353 and 423 K along with displacement damage up to 0.226 dpa. The implantation-induced increase in ductile-brittle transition temperature (DBTT) was estimated to be 98 K for the standard charpy V-notched (CVN) specimen implanted with 580 at. ppm He, through the conversion of small punch (SP) test results by an empirical relationship. It is clarified from comparison with neutron irradiation data that the increase in DBTT as well as implantation-induced hardening is interpreted simply in terms of displacement damage, suggesting that there is no significant effect of helium on both the irradiation hardening and the fracture toughness of the steel. No fracture mode change by the helium implantation was observed in the SP tests, showing a complete cleavage fracture mode in the lower shelf energy region.

Kasada, R.; Morimura, T.; Hasegawa, A.; Kimura, A.

2001-10-01

366

Effect of strain ageing on yield strength and post yield behavior of FCAW-G ferritic weld metal  

Energy Technology Data Exchange (ETDEWEB)

Strain aging can occur in pipeline steels that are subjected to thermal cycles after plastic deformation. This phenomenon is not well understood. This paper studies the effect of straining and aging on weld properties. More precisely, the study investigated the effect of micro-alloying on the microstructure and the properties of weld metal when a flux cored arc welding (FCAW-G) process is used. The weld metal strength (yield and tensile), the ductility (uniform and total elongation) and the toughness (Charpy V-Notch testing) are characterized for two different micro-alloying additions (titanium or vanadium). The tensile samples were also subjected to varying levels of strain. It is found that the yield and tensile strength increased with the increase in pre-strain, confirming the presence of strain aging. For the ductile to brittle transition temperature (DBTT), the results showed that the DBTT of the weld metal evolved slightly to higher temperatures with increase in pre-strain.

Narayanan, Badri K.; Brady, Noel; Ogborn, John [The Lincoln Electric Company, Cleveland, OH, (United States); Wang, Yong-Yi [Center for reliable energy systems, Columbus, OH, (United States)

2010-07-01

367

Middle-aged (12 month old) male rats show selective latent learning deficit.  

Science.gov (United States)

While many cognitive aging studies have been conducted using old (20+ months old) rats, few have demonstrated cognitive deficits in middle-aged (12 months old) rats. The present study was conducted to determine if deficits in latent learning (the acquisition of neutral information that does not immediately influence behavior) arise during middle age in rats. Twelve young (3 months old) and 12 middle-aged male Sprague-Dawley rats completed the latent cue preference (LCP) task, a conditioned cue preference (CCP) task in the same apparatus, and a reinforced spatial learning task using the Barnes maze. Results showed that the middle-aged rats were impaired on the latent learning (LCP) task relative to the young rats, but were not impaired on the CCP task or the spatial learning task. This may be because latent learning requires a functional entorhinal cortex, and the entorhinal cortex is one brain region that shows early age-related functional degeneration. PMID:20570402

Stouffer, Eric M; Yoder, Jessica E

2011-12-01

368

Different types of Budd-Chiari syndrome showed different circulation directions  

International Nuclear Information System (INIS)

Objective: To improve the knowledge for flow direction of renal-spleen circulation in Budd-Chiari syndrome and effects in treatment. Methods: Two Budd-Chiari syndrome patients with reno-splenic venous shunt were treated by PTA, and the circulation directions were investigated. Results: One case with hepatic vein occlusion showed the circulation from left renal-spleen vein to IVC; another case with IVC stenosis proximal to heart showed the flow direction from spleen left renal vein to varices and finally to SVC. The circulation disappeared after treatment with PTA. Conclusions: The direction of circulation in different types of Budd-Chiari with portal hypertension may be different and should be identified clearly for a suitable management

369

A Case of Budd-Chiari Syndrome Which Shows Space Occupying Lesion on Liver Scan  

International Nuclear Information System (INIS)

A twenty-one-year old man visited our hospital due to abdominal distension for a month. On the physical examination, there was severe abdominal distension with fluctuation and shifting dullness. The routine laboratory results were within normal range. On the Magnetic Resonance angiography, there wasn't any blood flow within the right and middle hepatic vein. So we concluded that the etiologic disease was Budd Chiari syndrome. On the liver scan, there was cold area (absence of radiouptake) on entire right lobe of the liver, increased uptake on the bone marrow and showed splenomegaly. This finding was similar to the liver mass occupying right lobe with underlying chronic liver disease. On the previous reports, it is quite uncommon finding that Budd-Chirari syndrome shows lesion like space occupying one on the liver scan. So we report this case with a review of the literature.

370

A Case of Budd-Chiari Syndrome Which Shows Space Occupying Lesion on Liver Scan  

Energy Technology Data Exchange (ETDEWEB)

A twenty-one-year old man visited our hospital due to abdominal distension for a month. On the physical examination, there was severe abdominal distension with fluctuation and shifting dullness. The routine laboratory results were within normal range. On the Magnetic Resonance angiography, there wasn't any blood flow within the right and middle hepatic vein. So we concluded that the etiologic disease was Budd Chiari syndrome. On the liver scan, there was cold area (absence of radiouptake) on entire right lobe of the liver, increased uptake on the bone marrow and showed splenomegaly. This finding was similar to the liver mass occupying right lobe with underlying chronic liver disease. On the previous reports, it is quite uncommon finding that Budd-Chirari syndrome shows lesion like space occupying one on the liver scan. So we report this case with a review of the literature.

Lee, Jeong Hae; Lee, Youn Ha; Seo, Dae Won; Jang, Tae Jong; Hwang, In Shup; Kim, Young Jung; Kim, So Yon; Lee, Gwon Jun [National Police Hospital, Seoul (Korea, Republic of)

1994-10-15

371

Shetland ponies (Equus caballus) show quantity discrimination in a matching-to-sample design.  

Science.gov (United States)

Numerical competence is one of the aspects of animal cognition with a long history of research interest, but few results are available for the horse. In the present study, we investigated the ability of three Shetland ponies to discriminate between different quantities of geometric symbols presented on a computer screen in a matching-to-sample arrangement. In Experiment 1, the ponies had to relate two similar quantities to another, paired in contrasts (1 vs. 2, 3 vs. 4 and 4 vs. 5) of the same stimulus (dot). Specific pairs of quantities (all differing by one) of up to five different geometrical symbols were displayed in Experiment 2. In each session, both quantities (more and less) were used as sample in such a way that each of the two quantities presented in one test served as positive and as negative stimulus, respectively. The three Shetland ponies were able to discriminate between the given quantities of dots by showing more than 80 % correct responses in two consecutive sessions. Only one of the ponies distinguished different shapes of geometric symbols at a level of 4 versus 5 items. The results show that all ponies were capable of visual quantity discrimination in the present matching-to-sample design, but task solving seemed more difficult when quantities were composed of heterogeneous stimuli. The present results confirm our hypothesis that the ponies based their decision on the matching concept of sameness and were not biased by a spontaneous preference for higher quantities. PMID:24831887

Gabor, Vivian; Gerken, Martina

2014-11-01

372

Analysis of Gentilly-2 pump trip tests showing the effect of electrical forces on pump rundown  

International Nuclear Information System (INIS)

The objective of this paper is to present SOPHT-G2/MiniSOPHT-G2 simulation results of two tests involving the primary pump P4 rundown at Gentilly-2 when the reactor was at very low power. The first test was a primary heat transport pump P4 trip conducted during the 2001 scheduled shutdown by opening the pump breaker. The second test is a slow power transfer from the main service transformer to the standby transformer of electric bus D06 supplying P4 performed during the 2001 restart. The first test is used to validate the SOPHT-G2 pump rundown model particularly in the first two seconds. The simulation results of the instrumented channels using MiniSOPHT-G2 show that the overall trends are well reproduced. The comparison between the SOPHT-G2 simulation results with the pump trip test and the slow power transfer test results shows that the pump rundown is just slightly faster for the power transfer test. In addition, taking into account the initial conditions before each test (i.e, primary system at 57oC for pump trip test and 175oC for power transfer test), the difference in the pump rundown time is significant. This effect can be important in some loss of class IV power events where a faster pump rundown can result in a higher power excursion due to additional void generation by comparison to pump rundown due to an opening of the pump breaker. (author)

373

African Haplogroup L mtDNA sequences show violations of clock-like evolution.  

Science.gov (United States)

A set of 96 complete mtDNA sequences that belong to the three major African haplogroups (L1, L2, and L3) was analyzed to determine if mtDNA has evolved as a molecular clock. Likelihood ratio tests (LRTs) were carried out with each of the haplogroups and with combined haplogroup sequence sets. Evolution has not been clock-like, neither for the coding region nor for the control region, in combined sets of African haplogroup L mtDNA sequences. In tests of individual haplogroups, L2 mtDNAs showed violations of a molecular clock under all conditions and in both the control and coding regions. In contrast, haplogroup L1 and L3 sequences, both for the coding and control regions, show clock-like evolution. In clock tests of individual L2 subclades, the L2a sequences showed a marked violation of clock-like evolution within the coding region. In addition, the L2a and L2c branch lengths of both the coding and control regions were shorter relative to those of the L2b and L2d sequences, a result that indicates lower levels of sequence divergence. Reduced median network analyses of the L2a sequences indicated the occurrence of marked homoplasy at multiple sites in the control region. After exclusion of the L2a and L2c sequences, African mtDNA coding region evolution has not significantly departed from a molecular clock, despite the results of neutrality tests that indicate the mitochondrial coding region has evolved under nonneutral conditions. In contrast, control region evolution is clock-like only at the haplogroup level, and it thus appears to have evolved essentially independently from the coding region. The results of the clock tests, the network analyses, and the branch length comparisons all caution against the use of simple mtDNA clocks. PMID:15190127

Howell, Neil; Elson, Joanna L; Turnbull, D M; Herrnstadt, Corinna

2004-10-01

374

Dielectric relaxation of a ferroelectric liquid crystal showing anomalous behaviour due to polarization inversion  

Science.gov (United States)

The present study reports the dielectric study of a ferroelectric liquid crystal (FLC) material Felix 016/030 showing anomalous dielectric behaviour. This anomalous behaviour is explained on the basis of a model of dynamically fluctuating mixture of two interconvertible conformers, whose relative density changes with temperature. We have observed Goldstone mode of dielectric relaxation in the frequency range covered. The experimental results have been corrected for low and high frequency range and used to determine dielectric permittivity. The anomalous behaviour of dielectric permittivity has also been verified by discussing the temperature dependence behaviour of PS/Sin ? term where Ps is spontaneous polarization of the sample.

Misra, Abhishek Kumar; Pandey, Kamal Kr; Tripathi, Pankaj Kr; Manohar, Rajiv

2013-06-01

375

Individual grain orientations and texture development of nanocrystalline electrodeposits showing abnormal grain growth  

International Nuclear Information System (INIS)

The electron backscatter diffraction (EBSD) technique has been used to determine grain orientations of abnormally grown grains in nanocrystalline Ni electrodeposits upon annealing. The results show that the first grown grains have a //ND orientation. Upon annealing further grain growth occurs and the preferred alignment of the abnormally growing grains changes from //ND to //ND. The subgrain coalescence model adopted from recrystallization is used to describe the occurrence of abnormal grain growth, and energy considerations are put forward for explaining the dominance of the //ND texture component after longer annealing treatments

376

Magnetite, a model system for mixed-valence oxides, does not show charge ordering  

International Nuclear Information System (INIS)

We have investigated the charge ordering (CO) in magnetite below the Verwey transition. A new set of half-integer and mixed-integer superlattice reflections of the low-temperature phase have been studied by x-ray resonant scattering. None of these reflections show features characteristic of CO. We demonstrate the absence of CO along the c axis with the periodicity of either the cubic lattice q=(001) or the doubled cubic lattice q=(001/2). This result suggests that the Verwey transition is caused by strong electron-phonon interaction instead of an electronic ordering on the octahedral Fe atoms

377

Neutron spectra at different High Flux Isotope Reactor (HFIR) pressure vessel surveillance locations  

International Nuclear Information System (INIS)

This project addresses the potential problem of radiation embrittlement of reactor pressure vessel (RPV) supports. Surveillance specimens irradiated at the High Flux Isotope Reactor (HFIR) at relatively low neutron flux levels (about 1.5E + 8 cm-2.s-1) and low temperatures (about 50 degrees C) showed embrittlement more rapidly than expected. Commercial power reactors have similar flux levels and temperatures at the level vessel support structures. The purposes of this work are to provide the neutron fluence spectra data that are needed to evaluate previously measured mechanical property changes in the HFIR, to explain the discrepancies in neutron flux levels between the nickel dosimeters and two other dosimeters, neptunium and beryllium, and to address any questions or peculiarities of the HFIR reactor environment. The current work consists of neutron and gamma transport calculations, dosimetry measurements, and least-squares logarithmic adjustment to obtain the best estimates for the neutron spectra and the related neutron exposure parameters. The results indicate that the fission rates in neptunium-237 (Np-237) and uranium-238 (U-238) and the helium production rates in beryllium-9 (Be-9) are dominated by photo-induced reactions. The displacements per atom rate for iron (dpa/s) from gamma rays is five times higher than the dpa/s from neutrons. The neutron fluxes in key 7, position 5 do not show any significant gradient in the surveillance capsule, but key 4 and key 2 showed differences in magnitude as well as in the shape of the spectrum. The stainless steel monitor in the V-notch of the Charpy specimens of the surveillance capsules is adequate to determine the neutron flux above 1.0 MeV at the desired V-notch location. Simultaneous adjustment of neutron and gamma fluxes with the measurements has been demonstrated and should avoid future problems with photo-induced reactions

378

Neutron spectra at different High Flux Isotope Reactor (HFIR) pressure vessel surveillance locations  

Energy Technology Data Exchange (ETDEWEB)

This project addresses the potential problem of radiation embrittlement of reactor pressure vessel (RPV) supports. Surveillance specimens irradiated at the High Flux Isotope Reactor (HFIR) at relatively low neutron flux levels (about 1.5E + 8 cm{sup {minus}2}.s{sup {minus}1}) and low temperatures (about 50{degrees}C) showed embrittlement more rapidly than expected. Commercial power reactors have similar flux levels and temperatures at the level vessel support structures. The purposes of this work are to provide the neutron fluence spectra data that are needed to evaluate previously measured mechanical property changes in the HFIR, to explain the discrepancies in neutron flux levels between the nickel dosimeters and two other dosimeters, neptunium and beryllium, and to address any questions or peculiarities of the HFIR reactor environment. The current work consists of neutron and gamma transport calculations, dosimetry measurements, and least-squares logarithmic adjustment to obtain the best estimates for the neutron spectra and the related neutron exposure parameters. The results indicate that the fission rates in neptunium-237 (Np-237) and uranium-238 (U-238) and the helium production rates in beryllium-9 (Be-9) are dominated by photo-induced reactions. The displacements per atom rate for iron (dpa/s) from gamma rays is five times higher than the dpa/s from neutrons. The neutron fluxes in key 7, position 5 do not show any significant gradient in the surveillance capsule, but key 4 and key 2 showed differences in magnitude as well as in the shape of the spectrum. The stainless steel monitor in the V-notch of the Charpy specimens of the surveillance capsules is adequate to determine the neutron flux above 1.0 MeV at the desired V-notch location. Simultaneous adjustment of neutron and gamma fluxes with the measurements has been demonstrated and should avoid future problems with photo-induced reactions.

Remec, I. [Josef Sefan Inst., Ljubljana (Slovenia); Kam, F.B. [Oak Ridge National Lab., TN (United States)

1993-12-01

379

Report on Results 2000  

Energy Technology Data Exchange (ETDEWEB)

This report discusses work being carried out in Norway to promote energy efficiency and the production of new renewable energy. An overall review of the quantifiable results of last year's activities at national level is available. It will serve to initiate an annual reporting tradition. The report represents a step towards an ongoing process for improved targeting and management of national efforts. During the course of the year 2000, NVE has evaluated and adjusted its activities and established a system involving indicators and reporting procedures. It is also important to take notice of the long-term work being undertaken to influence people's attitudes, even though this work is difficult to assess. NVE is investing in i.a. measures aimed at children and young people. Apart from directly influencing future energy users, this investment is also having an effect due to the children's encouragement of their parents to engage in more energy and environment-friendly behaviour. Published in 2000, the IEA report ''Trends in Norwegian Stationary Energy Use'' shows that total Norwegian energy consumption per GDP is not much higher than in other IEA countries, when adjusted for cold climate and industrial structure. However, Norwegians do stand out as intensive users of electricity. The IEA report shows a reduction of 10 TWh in energy usage when compared to the projected post 1990 figures. Energy efficiency activities have contributed towards this reduction. However, the potential for a more rational use of energy in Norway is still substantial and well documented. Based on experience most enterprises could save around 10% of energy used just by making changes to their operations, i.e. without major investments. Furthermore, the potential is growing because of massive technological developments in respect of energy usage, production and distribution. With this in mind, it is necessary to take full advantage of the extensive knowledge base regarding new renewable energy sources that is available through Nordic cooperation. During the course of the year a new energy body will be established to assume responsibility for initiatives encouraging more rational energy usage and more environment-friendly energy production. When this energy body commences operations next year, it will have a solid foundation on which to build further. It will inherit a well-founded system and an efficient structure. The results achieved during the year 2000 show savings in energy efficiency and the production of new renewable energy of 720 GWh. The gains could be even greater with clearly defined target-driven management. Due to internationalisation, Norway now has to deal with problems to which little attention was previously paid. All energy production has negative environmental co sequences. It is becoming increasingly obvious that we all need to contribute to limiting the damaging effects, while at the same time the international community needs to take the initiative in harmonizing measures which can result in a more sustainable and environment-friendly direction.

NONE

2001-07-01

380

Evaluation of the Influence That Was Produced by Phytoremediation of Soil Microorganisms at Oil Showings  

Science.gov (United States)

Phytoremediation has been identified as a potentially environmentally friendly and cost effective technique for the treatment of contaminated soil. However, phytoremediation has an unknown mechanism. In this study, we focus on the effects of the cultivation of Italian ryegrass on the soil microbes collected at oil showings, which were expected to have a variety of crude oil degradable microorganisms. We evaluated the number of crude oil degradable microorganism, microbial activity, microflora using the PCR-DGGE method and the change in the concentration of crude oil in the soil. The results indicated that the microflora was affected by the cultivation of Itarian ryegrass, and that the microbial activity and the number of crude oil degradable microorganisms were also improved by the cultivation. Moreover, the concentration of crude oil in the rhizosphere soil decreased significantly when compared to the uncultivated soil. These results suggested that cultivation could regulate microflora selectively, which degraded crude oil.

Kaimi, Etsuko; Kawakita, Morikazu; Mukaidani, Tsukasa; Fujiwara, Kazuhiro; Okada, Shin-Ichi; Yasuda, Yoshio

 
 
 
 
381

Lithium inclusion in indium metal-organic frameworks showing increased surface area and hydrogen adsorption  

Science.gov (United States)

Investigation of counterion exchange in two anionic In-Metal-Organic Frameworks (In-MOFs) showed that partial replacement of disordered ammonium cations was achieved through the pre-synthetic addition of LiOH to the reaction mixture. This resulted in a surface area increase of over 1600% in {Li [In(1,3 - BDC)2]}n and enhancement of the H2 uptake of approximately 275% at 80 000 Pa at 77 K. This method resulted in frameworks with permanent lithium content after repeated solvent exchange as confirmed by inductively coupled plasma mass spectrometry. Lithium counterion replacement appears to increase porosity after activation through replacement of bulkier, softer counterions and demonstrates tuning of pore size and properties in MOFs.

Bosch, Mathieu; Zhang, Muwei; Feng, Dawei; Yuan, Shuai; Wang, Xuan; Chen, Ying-Pin; Zhou, Hong-Cai

2014-12-01

382

Amphibian DNA shows marked genetic structure and tracks pleistocene climate change in northeastern Brazil.  

Science.gov (United States)

The glacial refugia paradigm has been broadly applied to patterns of species dynamics and population diversification. However, recent geological studies have demonstrated striking Pleistocene climate changes in currently semiarid northeastern Brazil at time intervals much more frequent than the climatic oscillations associated with glacial and interglacial periods. These geomorphic data documented recurrent pulses of wet regimes in the past 210,000 years that correlate with climate anomalies affecting multiple continents. While analyzing DNA sequences of two mitochondrial genes (cytochrome b and NADH-dehydrogenase subunit 2) and one nuclear marker (cellular-myelocytomatosis proto-oncogene) in the forest-associated frogs Proceratophrys boiei and Ischnocnema gr. ramagii, we found evidence of biological responses consistent with these pluvial maxima events. Sampled areas included old, naturally isolated forest enclaves within the semiarid Caatinga, as well as recent man-made fragments of humid coastal Atlantic forest. Results show that mtDNA lineages in enclave populations are monophyletic or nearly so, whereas nonenclave populations are polyphyletic and more diverse. The studied taxa show evidence of demographic expansions at times that match phases of pluvial maxima inferred from geological data. Divergence times between several populations fall within comparatively drier intervals suggested by geomorphology. Mitochondrial and nuclear data show local populations to be genetically structured, with some high levels of differentiation that suggest the need of further taxonomic work. PMID:17941838

Carnaval, Ana Carolina; Bates, John M

2007-12-01

383

Paddy plants inoculated with PGPR show better growth physiology and nutrient content under saline condition  

Scientific Electronic Library Online (English)

Full Text Available SciELO Chile | Language: English Abstract in english The possible role of plant growth-promoting rhizobacteria (PGPR) to alleviate salt stress during plant growth has been studied on paddy rice (Oryza sativa L.) 'GJ-17' under greenhouse conditions; the study included growth parameters, mineral concentration, and antioxidant enzyme level. Salinity redu [...] ced plant growth, but PGPR inoculation reduced its harmful effect up to 1% salinity. Plants inoculated with PGPR under saline conditions showed 16% higher germination, 8% higher survival, 27% higher dry weight, and 31% higher plant height. Similarly, PGPR inoculated plants showed increased concentrations of N(26%), P (16%), K (31%), and reduced concentrations of Na (71%) and Ca (36%) as compared to non-inoculated control plants under saline conditions. Plants inoculated with PGPR under saline conditions also showed significant variations in antioxidant levels and growth physiology. Results suggested that inoculation with PGPR Bacillus pumilus and Pseudomonas pseudoalcaligenes in salt-stressed plants could help to alleviate salt stress in the paddy.

Yachana, Jha; R.B, Subramanian.

2013-09-01

384

Do dolphins rehearse show-stimuli when at rest? Delayed matching of auditory memory  

Directory of Open Access Journals (Sweden)

Full Text Available The mechanisms underlying vocal mimicry in animals remain an open question. Delphinidae are able to copy sounds from their environment that are not produced by conspecifics. Usually, these mimicries occur associated with the context in which they were learned. No reports address the question of separation between auditory memory formation and spontaneous vocal copying although the sensory and motor phases of vocal learning are separated in a variety of songbirds. Here we show that captive bottlenose dolphins produce, during their nighttime resting periods, non-dolphin sounds that they heard during performance shows. Generally, in the middle of the night, these animals produced vocal copies of whale sounds that had been broadcast during daily public shows. As their life history was fully known, we know that these captive dolphins had never had the opportunity to hear whale sounds before then. Moreover, recordings made before the whale sounds started being broadcast revealed that they had never emitted such sounds before. This is to our knowledge the first evidence for a separation between formation of auditory memories and the process of learning to produce calls that match these memories in a marine mammal. One hypothesis is that dolphins may rehearse some special events heard during the daytime and that they then express vocally what could be conceived as a more global memory. These results open the way for broader views on how animals might rehearse life events while resting or maybe dreaming.

DorotheeKremers

2011-12-01

385

A novel thiazolidinedione derivative TD118 showing selective algicidal effects for red tide control.  

Science.gov (United States)

Thiazolidinedione (TD) derivatives have been found to have an algicidal effect on harmful algal bloom microalgae. In this study, 75 TD derivatives were synthesized and analyzed for algicidal activity. Among these synthetic TDs, 18 TD derivatives showed specific algicidal activity on two strains belonging to the classes Raphidophyceae (Chattonella marina and Heterosigma akashiwo) and Dinophyceae (Cochlodinium polykrikoides). Two strains belonging to Bacillariophyceae (Navicula pelliculosa and Phaeodactylum EPV), one strain belonging to Dinophyceae (Amphidinium sp.), and a Eustigmatophycean microalga (Nannochloropsis oculata) showed less sensitivity to the TD derivatives than the other two phyla. The most reactive TD derivative, compound 2 (TD118), was selected and tested for morphological and physiological changes. TD118 effectively damaged the cell membrane of C. marina, H. akashiwo and C. polykrikoides. The O? evolution and photosystem II efficiency (F(v)/F(m)) of C. marina, H. akashiwo and C. polykrikoides were also severely reduced by TD118 treatment. Amphidinium sp., N. pelliculosa, Phaeodactylum EPV and N. oculata showed less reduction of O? evolution and the F(v)/F(m) by TD118. These results imply that the species-specific TD structure relationship may be due to structural and/or physiological differences among microalgal species. PMID:24374490

Wu, Ying; Lee, Yew; Jung, Seul-Gi; Kim, Minju; Eom, Chi-Yong; Kim, Si Wouk; Cho, Hoon; Jin, Eonseon

2014-05-01

386

Do dolphins rehearse show-stimuli when at rest? Delayed matching of auditory memory.  

Science.gov (United States)

The mechanisms underlying vocal mimicry in animals remain an open question. Delphinidae are able to copy sounds from their environment that are not produced by conspecifics. Usually, these mimicries occur associated with the context in which they were learned. No reports address the question of separation between auditory memory formation and spontaneous vocal copying although the sensory and motor phases of vocal learning are separated in a variety of songbirds. Here we show that captive bottlenose dolphins produce, during their nighttime resting periods, non-dolphin sounds that they heard during performance shows. Generally, in the middle of the night, these animals produced vocal copies of whale sounds that had been broadcast during daily public shows. As their life history was fully known, we know that these captive dolphins had never had the opportunity to hear whale sounds before then. Moreover, recordings made before the whale sounds started being broadcast revealed that they had never emitted such sounds before. This is to our knowledge the first evidence for a separation between formation of auditory memories and the process of learning to produce calls that match these memories in a marine mammal. One hypothesis is that dolphins may rehearse some special events heard during the daytime and that they then express vocally what could be conceived as a more global memory. These results open the way for broader views on how animals might rehearse life events while resting or maybe dreaming. PMID:22232611

Kremers, Dorothee; Jaramillo, Margarita Briseño; Böye, Martin; Lemasson, Alban; Hausberger, Martine

2011-01-01

387

Leukocyte-technetium-99m uptake in Crohn’s disease: Does it show subclinical disease?  

Directory of Open Access Journals (Sweden)

Full Text Available AIM: To evaluate inflammatory activity in patients with Crohn’s disease (CD using technetium-99m-hexamethylpropyleneamine oxime (99mTc-HMPAO granulocyte scintigraphy.METHODS: Twenty patients (7 male and 13 female with CD and five healthy volunteers were selected for 99mTc-HMPAO granulocyte scintigraphy. The Crohn’s Disease Activity Index (CDAI, blood tests and C-reactive protein (CRP of each patient were performed 7 d before the scintigraphic images. The leukocytes were labeled according to the International Society of Radiolabeled Blood Elements (ISORBE consensus protocol and the scintigraphic images, including single photon emission computed tomography, were obtained 30 min and 2 h after injection of the radiolabeled leukocytes.RESULTS: The labeling yield of the leukocytes with the lipophilic complex 99mTc-HMPAO was 55.0% ± 10%. Six of the 20 patients (30% presented congruent results for the three parameters investigated (CDAI, Scintigraphic Index and CRP. On the other hand, 14 patients (70% did not show congruent results. There was no significant correlation between the indices analyzed according to the Spearman test (P > 0.05, n = 20.CONCLUSION: The results suggest that 99mTc-HMPAO-labeled leukocyte scintigraphy could be important for determining inflammatory activity in CD even in the absence of clinical symptoms.

Luciene G Mota, Luiz GV Coelho, Carlos JR Simal, Maria LA Ferrari, Clodomiro Toledo, Josep Martin-Comin, Simone OF Diniz, Valbert N Cardoso

2010-01-01

388

Leukocyte-technetium-99m uptake in Crohn's disease: Does it show subclinical disease?  

Science.gov (United States)

AIM: To evaluate inflammatory activity in patients with Crohn’s disease (CD) using technetium-99m-hexamethylpropyleneamine oxime (99mTc-HMPAO) granulocyte scintigraphy. METHODS: Twenty patients (7 male and 13 female) with CD and five healthy volunteers were selected for 99mTc-HMPAO granulocyte scintigraphy. The Crohn’s Disease Activity Index (CDAI), blood tests and C-reactive protein (CRP) of each patient were performed 7 d before the scintigraphic images. The leukocytes were labeled according to the International Society of Radiolabeled Blood Elements (ISORBE) consensus protocol and the scintigraphic images, including single photon emission computed tomography, were obtained 30 min and 2 h after injection of the radiolabeled leukocytes. RESULTS: The labeling yield of the leukocytes with the lipophilic complex 99mTc-HMPAO was 55.0% ± 10%. Six of the 20 patients (30%) presented congruent results for the three parameters investigated (CDAI, Scintigraphic Index and CRP). On the other hand, 14 patients (70%) did not show congruent results. There was no significant correlation between the indices analyzed according to the Spearman test (P > 0.05, n = 20). CONCLUSION: The results suggest that 99mTc-HMPAO-labeled leukocyte scintigraphy could be important for determining inflammatory activity in CD even in the absence of clinical symptoms. PMID:20082484

Mota, Luciene G; Coelho, Luiz GV; Simal, Carlos JR; Ferrari, Maria LA; Toledo, Clodomiro; Martin-Comin, Josep; Diniz, Simone OF; Cardoso, Valbert N

2010-01-01

389

Task control signals in pediatric Tourette syndrome show evidence of immature and anomalous functional activity  

Directory of Open Access Journals (Sweden)

Full Text Available Tourette Syndrome (TS is a pediatric movement disorder that may affect control signaling in the brain. Previous work has proposed a dual-networks architecture of control processing involving a task-maintenance network and an adaptive control network (Dosenbach et al., 2008. A prior resting-state functional connectivity MRI (rs-fcMRI analysis in TS has revealed functional immaturity in both putative control networks, with “anomalous” correlations (i.e. correlations outside the typical developmental range limited to the adaptive control network (Church et al., 2009. The present study used functional MRI (fMRI to study brain activity related to adaptive control (by studying start-cues signals, and to task-maintenance (by studying signals sustained across a task set. Two hypotheses from the previous rs-fcMRI results were tested. First, adaptive control (i.e., start-cue activity will be altered in TS, including activity inconsistent with typical development (“anomalous”. Second, group differences found in task maintenance (i.e., sustained activity will be consistent with functional immaturity in TS. We examined regions found through a direct comparison of adolescents with and without TS, as well as regions derived from a previous investigation that showed differences between unaffected children and adults. The TS group showed decreased start-cue signal magnitude in regions where start-cue activity is unchanged over typical development, consistent with anomalous adaptive control. The TS group also had higher magnitude sustained signals in frontal cortex regions that overlapped with regions showing differences over typical development, consistent with immature task maintenance in TS. The results demonstrate task-related fMRI signal differences anticipated by the atypical functional connectivity found previously in adolescents with TS, strengthening the evidence for functional immaturity and anomalous signaling in control networks in adolescents with TS.

FrancisM Miezin

2009-11-01

390

A novel lectin from Agrocybe aegerita shows high binding selectivity for terminal N-acetylglucosamine.  

Science.gov (United States)

A novel lectin was isolated from the mushroom Agrocybe aegerita (designated AAL-2) by affinity chromatography with GlcNAc (N-acetylglucosamine)-coupled Sepharose 6B after ammonium sulfate precipitation. The AAL-2 coding sequence (1224 bp) was identified by performing a homologous search of the five tryptic peptides identified by MS against the translated transcriptome of A. aegerita. The molecular mass of AAL-2 was calculated to be 43.175 kDa from MS, which was consistent with the data calculated from the amino acid sequence. To analyse the carbohydrate-binding properties of AAL-2, a glycan array composed of 465 glycan candidates was employed, and the result showed that AAL-2 bound with high selectivity to terminal non-reducing GlcNAc residues, and further analysis revealed that AAL-2 bound to terminal non-reducing GlcNAc residues with higher affinity than previously well-known GlcNAc-binding lectins such as WGA (wheatgerm agglutinin) and GSL-II (Griffonia simplicifolia lectin-II). ITC (isothermal titration calorimetry) showed further that GlcNAc bound to AAL-2 in a sequential manner with moderate affinity. In the present study, we also evaluated the anti-tumour activity of AAL-2. The results showed that AAL-2 could bind to the surface of hepatoma cells, leading to induced cell apoptosis in vitro. Furthermore, AAL-2 exerted an anti-hepatoma effect via inhibition of tumour growth and prolongation of survival time of tumour-bearing mice in vivo. PMID:22268569

Jiang, Shuai; Chen, Yijie; Wang, Man; Yin, Yalin; Pan, Yongfu; Gu, Bianli; Yu, Guojun; Li, Yamu; Wong, Barry Hon Cheung; Liang, Yi; Sun, Hui

2012-04-15

391

Diabetes patients show different time-course of myocardial perfusion improvement after coronary artery bypass grafting  

International Nuclear Information System (INIS)

Diabetes mellitus is an independent risk factor of cardiovascular disease. Diabetes is known to cause microangiopathy. The microangiopathy is hardly detectable on the coronary angiography. Myocardial perfusion imaging shows the resultant perfusion status which reflects the microangiopathy. For patients who underwent revascularization, the microangiopathy could affect the myocardial perfusion improvement. Diabetes patients probably experience the different myocardial perfusion improvement as compared to the non-diabetes patients although they have similar angiographic findings. The aim of this study is to find out whether there is a time-course difference of perfusion improvement between the diabetes and non diabetes patients who showed patent angiographic findings after coronary artery grafting surgery (CABG). A total of 129 patients who underwent coronary artery bypass grafting surgery were enrolled in this study. Myocardial SPECTs performed at previous, short-term (3 month), and mid-term (1 year) to CABG. One-year follow up angiography was done 411±121 days after surgery. Graft patency was determined according to the FitzGibbon et al. Segments were assigned to vascular territories using a 20 segment model. The segments of excellent patency were included in this study. Time course differences of concerned segments were analyzed using RMANOVA. The number of segments enrolled was 764 of diabetes and 1083 of non-diabetes. At short-term follow up, reversibility score was 2.8±8.1% in diabetes and 0.3±7.5% in non-diabetes. At long-term follow up, reversibility score was 1.8±8.0% in diabetes and 0.1±7.3% in non-diabetes. The time-course of reversibility score was significantly different between the diabetes and non diabetes (p<0.001) Diabetic segments showed high residual reversibility score than non-diabetic segments after CABG although the angiographic finding was patent in both groups. This result is maybe attributable to microangiopathy induced by diabetes

392

A new two-phase dimeticone pediculicide shows high efficacy in a comparative bioassay  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract Background Dimeticones kill head lice by physical means. Here we assessed in a comparative bioassay the ex vivo efficacy of "NYDA® sensitiv", a new two-phase dimeticone-based pediculicide similar to a product established on the market, but without fragrances. Methods We compared efficacy of the new product to a positive dimeticone control group, a sample of four other insecticidal and natural head lice products marketed in Germany, and an untreated control. In a bioassay, lice were exposed ex vivo to products and examined for activity for up to 24 hours, following a standard protocol. Results After 6 and 24 hours, 13.7 and 88.5% of untreated control lice did not show major vital signs. In contrast, no lice showed major vital signs 5 minutes after treatment with the new product or the control dimeticone group (NYDA®. This effect persisted at all observation points (100% efficacy. Efficacy of 0.5% permethrin (Infectopedicul® ranged between 76 and 96% in evaluations between 5 min and 6 hours. All lice treated with a coconut-based compound (mosquito® Läuseshampoo did not show major vital signs after 5 min, but mortality was only 58% after one hour. Pyrethrum extract (Goldgeist® forte showed an efficacy of 22 - 52% between 5 min and 3 hours after treatment; after 6 hours, 76% of lice were judged dead. An oxyphthirine®-based compound (Liberalice DUO LP-PRO® killed 22 - 54% of lice in the first 6 hours. Conclusions The two-phase dimeticone compound NYDA® sensitiv is highly efficacious. The removal of fragrances as compared to an established dimeticone product did not affect in vitro efficacy.

Liesenfeld Oliver

2009-12-01

393

Examination of parameters affecting overload fracture behavior of flaw-tip hydrides in Zr-2.5Nb pressure tubes in Candu reactors  

Energy Technology Data Exchange (ETDEWEB)

Service-induced flaws in Zr-2.5Nb alloy pressure tubes in Candu (Canada Deuterium Uranium Reactors) nuclear reactors are susceptible to a crack initiation and growth mechanism known as Delayed Hydride Cracking (DHC), which is a repetitive process that involves hydrogen diffusion, hydride precipitation, growth and fracture of a hydride region at the flaw-tip under a constant load. Crack initiation may also occur under another loading condition when the hydride region is subjected to an overload. An overload occurs when the hydride region at the flaw tip is loaded to a stress higher than that at which this region is formed such as when the reactor experiences a transient pressure higher than the normal operating pressure where the hydride region is formed. Flaw disposition requires justification that the hydride region overload will not fracture the hydride region, and initiate DHC. In this work, monotonically increasing load experiments were performed on unirradiated Zr-2.5Nb pressure tube specimens containing simulated debris frets (V-notch) and bearing pad frets (BPF, U-shape notch) to examine overload fracture behavior of flaw-tip hydrides formed under hydride ratcheting conditions. Hydride cracking in the overload tests was detected by the acoustic emission technique and confirmed by post-test metallurgical examination. Test results indicate that the resistance to overload fracture is affected by a number of parameters including hydride formation stress, flaw shape (V-notch vs. BPF) and flaw radius (0.015 mm vs. 0.1 mm). The notch-tip hydride morphologies were examined by optical microscopy and scanning electron microscopy (SEM) which show that they are affected by the hydride formation conditions, resulting in different overload fracture resistance. Finite element stress analyses were also performed to obtain flaw-tip stress distributions for interpretation of the test results. (authors)

Cui, J.; Shek, G.K. [Kinectrics Inc., Toronto, Ontario (Canada); Wang, Z.R. [Toronto Univ., Dept. of Materials Science and Engineering, Toronto, Ontario (Canada)

2007-07-01

394

Examination of parameters affecting overload fracture behavior of flaw-tip hydrides in Zr-2.5Nb pressure tubes in Candu reactors  

International Nuclear Information System (INIS)

Service-induced flaws in Zr-2.5Nb alloy pressure tubes in Candu (Canada Deuterium Uranium Reactors) nuclear reactors are susceptible to a crack initiation and growth mechanism known as Delayed Hydride Cracking (DHC), which is a repetitive process that involves hydrogen diffusion, hydride precipitation, growth and fracture of a hydride region at the flaw-tip under a constant load. Crack initiation may also occur under another loading condition when the hydride region is subjected to an overload. An overload occurs when the hydride region at the flaw tip is loaded to a stress higher than that at which this region is formed such as when the reactor experiences a transient pressure higher than the normal operating pressure where the hydride region is formed. Flaw disposition requires justification that the hydride region overload will not fracture the hydride region, and initiate DHC. In this work, monotonically increasing load experiments were performed on unirradiated Zr-2.5Nb pressure tube specimens containing simulated debris frets (V-notch) and bearing pad frets (BPF, U-shape notch) to examine overload fracture behavior of flaw-tip hydrides formed under hydride ratcheting conditions. Hydride cracking in the overload tests was detected by the acoustic emission technique and confirmed by post-test metallurgical examination. Test results indicate that the resistance to overload fracture is affected by a number of parameters including hydride formation stress, flaw shapeuding hydride formation stress, flaw shape (V-notch vs. BPF) and flaw radius (0.015 mm vs. 0.1 mm). The notch-tip hydride morphologies were examined by optical microscopy and scanning electron microscopy (SEM) which show that they are affected by the hydride formation conditions, resulting in different overload fracture resistance. Finite element stress analyses were also performed to obtain flaw-tip stress distributions for interpretation of the test results. (authors)

395

Computer-aided detection of lung cancer on chest radiographs: differences in the interpretation time of radiologist's showing vs. not showing improvement with CAD  

Science.gov (United States)

Using data from a clinical trial of a commercial CAD system for lung cancer detection, we are comparing the time used for interpreting chest radiographs between the radiologists showing improvement in detecting lung cancer with computer assistance to those not showing improvement. While measurement showed that the 15 radiologists as a group showed improvement (the Az was 0.8288 in independent reading, and 0.8654 in sequential reading with CAD, improvement has a P-value of 0.0058), there were 9 radiologists who showed improvement and 6 who did not. The behavior of the radiologists differed between the cases that contained cancer and those that were cancer-free. For the cases that contained a cancer, there was no statistically significant difference in time between the two groups (P-value 0.26). For the cancer-free cases, we found a statistically significant greater interpretation time for the radiologists whose performance in cancer detection was better with computer assistance compared to those without improvement (P-value 0.02). This work shows that radiologists who increased their detection of lung cancer using CAD, compared to those who showed no improvement, significantly increased their reading time when they determined that true negative cases for cancer were indeed true negative cases, but did not increase reading time for true positive decision on cancer cases.

Osicka, Teresa; Freedman, Matthew T.; Lo, Shih-Chung B.; Lure, Fleming; Xu, Xin-Wei; Lin, Jesse; Zhao, Hui; Zhang, Ron

2003-05-01

396

Cechy gatunkowe morning show na przyk?adzie audycji Wstawaj, szkoda dnia w radiu RMF FM  

Digital Repository Infrastructure Vision for European Research (DRIVER)

The morning show is a new journalistic genre found in commercial broadcasting. This type of morning show consists of a few hours of block programming. A morning show consists of popular music, game shows, aspects of a talk show, call-in jokes, and news reports, but the most important feature is the personality DJs. This article is an attempt at characterizing this genre.

Garcarek-sikorska, Agnieszka

2014-01-01

397

El SHOW DE JORGE BARÓN como paradigma de neopopulismo cultural en la televisión Colombiana / JORGE BARON'S show as paradigm of cultural neo-populism in the colombian television  

Scientific Electronic Library Online (English)

Full Text Available SciELO Colombia | Language: Spanish Abstract in spanish Este artículo parte de la investigación de campo sobre El Show de las Estrellas, el programa musical más antiguo y popular de la televisión colombiana. El análisis de caso es un pretexto para replantear la discusión sobre políticas culturales en el contexto -aparentemente paradójico- de violencia es [...] tructural, privatización y auge del populismo de derecha que caracteriza la política en Colombia en los últimos años. Abstract in english This article comes from the investigation field of the Stars Show (El Show de las Estrellas), the oldest and most popular musical TV show in Colombian television. The case analysis is an excuse to reframe the discussion on cultural policies in the context, apparently paradoxical, of structural viole [...] nce, privatization and peak of the right populism that characterizes the Colombian politics in the last years.

Isabel Noemí, Rodríguez; Adolfo, Chaparro Amaya.

398

El SHOW DE JORGE BARÓN como paradigma de neopopulismo cultural en la televisión Colombiana / JORGE BARON'S show as paradigm of cultural neo-populism in the colombian television  

Scientific Electronic Library Online (English)

Full Text Available SciELO Colombia | Language: Spanish Abstract in spanish Este artículo parte de la investigación de campo sobre El Show de las Estrellas, el programa musical más antiguo y popular de la televisión colombiana. El análisis de caso es un pretexto para replantear la discusión sobre políticas culturales en el contexto -aparentemente paradójico- de violencia es [...] tructural, privatización y auge del populismo de derecha que caracteriza la política en Colombia en los últimos años. Abstract in english This article comes from the investigation field of the Stars Show (El Show de las Estrellas), the oldest and most popular musical TV show in Colombian television. The case analysis is an excuse to reframe the discussion on cultural policies in the context, apparently paradoxical, of structural viole [...] nce, privatization and peak of the right populism that characterizes the Colombian politics in the last years.

Isabel Noemí, Rodríguez; Adolfo, Chaparro Amaya.

2010-12-01

399

El SHOW DE JORGE BARÓN como paradigma de neopopulismo cultural en la televisión Colombiana JORGE BARON'S show as paradigm of cultural neo-populism in the colombian television  

Directory of Open Access Journals (Sweden)

Full Text Available Este artículo parte de la investigación de campo sobre El Show de las Estrellas, el programa musical más antiguo y popular de la televisión colombiana. El análisis de caso es un pretexto para replantear la discusión sobre políticas culturales en el contexto -aparentemente paradójico- de violencia estructural, privatización y auge del populismo de derecha que caracteriza la política en Colombia en los últimos años.This article comes from the investigation field of the Stars Show (El Show de las Estrellas, the oldest and most popular musical TV show in Colombian television. The case analysis is an excuse to reframe the discussion on cultural policies in the context, apparently paradoxical, of structural violence, privatization and peak of the right populism that characterizes the Colombian politics in the last years.

Isabel Noemí Rodríguez

2010-12-01

400

High and low sensation seeking adolescents show distinct patterns of brain activity during reward processing.  

Science.gov (United States)

Previous research has shown that personality characteristics, such as sensation seeking (SS), are strong predictors of risk-taking behavior during adolescence. However, the relationship between levels of SS and brain response has not been studied during this time period. Given the prevalence of risky behavior during adolescence, it is important to understand neurobiological differences in reward sensitivity between youth with high and low SS personalities. To this end, we used functional magnetic resonance imaging (fMRI) to examine differences in brain activity in an adolescent sample that included 27 high (HSS) and 27 low sensation seekers (LSS), defined by the Impulsive Sensation Seeking scale of the Zuckerman-Kuhlman Personality Questionnaire (Zuckerman et al., 1993). In the scanner, participants played a modified Wheel of Fortune decision-making task (Cservenka and Nagel, 2012) that resulted in trials with monetary Wins or No Wins. We compared age- and sex-matched adolescent HSS and LSS (mean age=13.94±1.05) on brain activity by contrasting Win vs. No Win trials. Our findings indicate that HSS show greater bilateral insular and prefrontal cortex (PFC) brain response on Win vs. No Win compared to LSS. Analysis of simple effects showed that while LSS showed comparable brain activity in these areas during Wins and No Wins, HSS showed significant differences in brain response to winning (activation) vs. not winning (deactivation), with between-group comparison suggesting significant differences in brain response, largely to reward absence. Group differences in insular activation between reward receipt and absence may suggest weak autonomic arousal to negative outcomes in HSS compared with LSS. Additionally, since the PFC is important for goal-directed behavior and attention, the current results may reflect that HSS allocate fewer attentional resources to negative outcomes than LSS. This insensitivity to reward absence in HSS may lead to a greater likelihood of maladaptive choices when negative consequences are not considered, and may be an early neural marker of decreased loss sensitivity that has been seen in addiction. This neurobiological information may ultimately be helpful in establishing prevention strategies aimed at reducing youth risk-taking and suggests value in further examination of neural associations with personality characteristics during adolescence. PMID:23142276

Cservenka, Anita; Herting, Megan M; Seghete, Kristen L Mackiewicz; Hudson, Karen A; Nagel, Bonnie J

2013-02-01

 
 
 
 
401

Grain size and temperature influence on the toughness of a CuAlBe shape memory alloy  

International Nuclear Information System (INIS)

Research highlights: ? This work evaluated the capacity of a CuAlBe alloy to absorb energy until rupture. ? The V-notch Charpy test was adopted at -150, -100, -50, 0, 50, 100 and 150 deg. C. ? Charpy tests were complemented by DSC, DSC with optical microscope and by SEM. ? First work to analyze the toughness of a CuAlBe alloy based on the Charpy test. ? The results are of relevant value to enhance the understanding of the CuAlBe alloy. - Abstract: This work is a study of the influence of grain size and temperature on the toughness of CuAlBe shape memory alloys with (CuAlBeNbNi) and without NbNi (CuAlBe) grain refiner elements. The toughness analysis was based on the V-notch Charpy impact test under temperatures of -150, -100, -50, 0, 50, 100 and 150 deg. C. A statistical analysis of the results led to the conclusion that the toughness of both alloys was influenced by temperature and grain size. The CuAlBeNbNi alloy absorbed higher impact energy than the CuAlBe alloy showing that the refining elements improved the toughness of the alloy. To confirm and complement these findings, the fracture surfaces were evaluated by stereomicroscopy. Smooth homogeneous surfaces and rough heterogonous surfaces were detected for the CuAlBeNbNi and CuAlBe alloys, respectively. Predominately brittle zones were confirmed by scanning electron microscopy in both alloys. Furthermore, to determine the phase transformation temperatures and the associated microstructures, the alloys wed microstructures, the alloys were assessed by conventional differential scanning calorimetry (DSC) and DSC with optical microscopy.

402

Cyclosporine A - treated nephrotic children show impaired vasodilatation but no autonomic neuropathy  

Science.gov (United States)

Introduction The aim of the study was to determine the effect of long-term cyclosporine A (CsA) treatment in children with idiopathic nephrotic syndrome on autonomic nerve function and peripheral blood flow assessed with thermography. Material and methods The study group consisted of 19 nephrotic children treated with cyclosporine A compared to 16 healthy children. The assessment of blood flow was made based on the results of thermographic measurements during the cold stress test by an infrared radiation registering camera. Ewing's battery of non-invasive tests was used to assess autonomic function. Results The study showed diminished temperature increase after the cooling test in children with nephrotic syndrome treated with CsA. Sympathetic activity test results were comparable to healthy children. Conclusions It may be hypothesized that cyclosporine A administered even in low doses induces small vessel dysfunction measured by the thermographic method. This effect seems to be independent of sympathetic nervous system involvement, which was absent in cyclosporine A treated nephrotic children. PMID:22371802

Czupryniak, Aneta; Kaluzynska, Anna; Poltorak-Krawczyk, Anna; Ostrowski, Bartosz; Wiecek, Boguslaw

2010-01-01

403

Semantic Dementia Shows both Storage and Access Disorders of Semantic Memory  

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Objective. Previous studies have shown that some patients with semantic dementia (SD) have memory storage disorders, while others have access disorders. Here, we report three SD cases with both disorders. Methods. Ten pictures and ten words were prepared as visual stimuli to determine if the patients could correctly answer names and select pictures after hearing the names of items (Card Presentation Task, assessing memory storage disorder). In a second task, the viewing time was set at 20 or 300 msec (Momentary Presentation Task, evaluating memory access disorder) using items for which correct answers were given in the first task. The results were compared with those for 6 patients with Alzheimer's disease (AD). Results. The SD patients had lower scores than the AD group for both tasks, suggesting both storage and access disorders. The AD group had almost perfect scores on the Card Presentation Task but showed impairment on the Momentary Presentation Task, although to a lesser extent than the SD cases. Conclusions. These results suggest that SD patients have both storage and access disorders and have more severe access disorder than patients with AD. PMID:24825958

Takahashi, Yumi; Meguro, Kenichi; Nakatsuka, Masahiro; Kasai, Mari; Akanuma, Kyoko; Yamaguchi, Satoshi

2014-01-01

404

26 CFR 1.513-3 - Qualified convention and trade show activity.  

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... true Qualified convention and trade show activity. 1.513-3 Section 1...513-3 Qualified convention and trade show activity. (a) Introduction —(1...b) provide that convention and trade show activities carried on by a...

2010-04-01

405

47 CFR 76.7 - General special relief, waiver, enforcement, complaint, show cause, forfeiture, and declaratory...  

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...relief, waiver, enforcement, complaint, show cause, forfeiture, and declaratory ruling...relief, waiver, enforcement, complaint, show cause, forfeiture, and declaratory ruling...complaint or disputed question, issue a show cause order, revoke the...

2010-10-01

406

22 CFR 92.87 - Consular responsibility for serving orders to show cause.  

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...Consular responsibility for serving orders to show cause. 92.87 Section 92.87...Consular responsibility for serving orders to show cause. Officers of the Foreign Service are required to serve orders to show cause issued in contempt proceedings...

2010-04-01

407

45 CFR 1303.12 - Summary suspension and opportunity to show cause.  

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... Summary suspension and opportunity to show cause. 1303.12 Section 1303.12... Summary suspension and opportunity to show cause. (a) After receiving concurrence...without prior notice and an opportunity to show cause if it is determined that...

2010-10-01

408

30 CFR 843.14 - Service of notices of violation, cessation orders, and show cause orders.  

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...notices of violation, cessation orders, and show cause orders. 843.14 Section 843...notices of violation, cessation orders, and show cause orders. (a) A notice of violation, cessation order, or show cause order shall be served on the...

2010-07-01

409

77 FR 13522 - Safety Zone; Baltimore Air Show, Patapsco River, Baltimore, MD  

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...1625-AA00 Safety Zone; Baltimore Air Show, Patapsco River, Baltimore, MD AGENCY...safety zone during the ``Baltimore Air Show,'' which consists of aerial practices, performance demonstrations and air shows, to be held over certain waters of...

2012-03-07

410

77 FR 27123 - Safety Zone; Baltimore Air Show, Patapsco River, Baltimore, MD  

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...1625-AA00 Safety Zone; Baltimore Air Show, Patapsco River, Baltimore, MD AGENCY...safety zone during the ``Baltimore Air Show'', which consists of aerial practices, performance demonstrations and air shows, to be held over certain waters of...

2012-05-09

411

75 FR 35296 - Safety Zones; 2010 Muskegon Summer Celebration Air Show, Muskegon Lake, Muskegon, MI  

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...2010 Muskegon Summer Celebration Air Show, Muskegon Lake, Muskegon, MI AGENCY...the 2010 Muskegon Summer Celebration Air Show. These temporary safety zones are necessary...from the hazards associated with an air show. DATES: This rule is effective from...

2010-06-22

412

76 FR 18391 - Safety Zone; Texas International Boat Show Power Boat Races; Corpus Christi Marina, Corpus...  

Science.gov (United States)

...Safety Zone; Texas International Boat Show Power Boat Races; Corpus Christi Marina...place during the Texas International Boat Show. The North American Tri-Hull Championship...Safety Zone; Texas International Boat Show Power Boat Races, Corpus Christi...

2011-04-04

413

Mycological study for a management plan of a neotropical show cave (Brazil  

Directory of Open Access Journals (Sweden)

Full Text Available Caves are stable environments with characteristics favoring the development of microorganisms. The allocthonous input of organic matter and microbes into the warm Neotropical caves may favor the development of filamentous fungi, including pathogenic species. Histoplasma capsulatum is a pathogenic species commonly found in caves and associated with bat and bird guano. Many Brazilian caves have been historically visited due to scenic and religious tourism. The objective of this study was to perform a microbiology study for a management plan of a show cave in Brazil, focusing on the presence and distribution of pathogenic and opportunistic fungi in the cave. Statistic analysis was used to verify the influence of touristic activity on airborne fungi spore load. Fungi were isolated from air and guano in Lapa Nova Cave. Samples were obtained through serial dilution, direct and settle plate techniques. For H. capsulatum, samples were incubated in specific media and conditions. Airborne fungal spore load was compared prior and during visitation and statistically analyzed. A total of 2,575 isolates from the genera Aspergillus, Calcarisporium, Chaetomium, Cladosporium, Curvularia, Emericella, Eurotium, Fusarium, Geotrichum, Gliocladium, Mucor, Purpureocillium, Paecilomyces, Penicillium, Rhizopus and Trichoderma were identified. Histoplasma capsulatum was not isolated from the cave. Eleven opportunistic species were identified. Significant (p<0.05 variations on fungal richness in the air occurred due to cave visitation. Areas of potential microbiologic risks were indicated and management actions suggested. The results suggest a diverse community inhabiting the cave. Possible opportunistic species should be monitored in show caves and microbiota should always be included in the elaboration of cave management plans. This is the first detailed microbiologic study for a management plan of a show cave in the country. It provides relevant information for future management plans.

Erika Linzi Silva Taylor

2013-09-01

414

Chronic Myeloid Leukemia Patients Sensitive and Resistant to Imatinib Treatment Show Different Metabolic Responses  

Science.gov (United States)

The BCR-ABL tyrosine kinase inhibitor imatinib is highly effective for chronic myeloid leukemia (CML). However, some patients gradually develop resistance to imatinib, resulting in therapeutic failure. Metabonomic and genomic profiling of patients' responses to drug interventions can provide novel information about the in vivo metabolism of low-molecular-weight compounds and extend our insight into the mechanism of drug resistance. Based on a multi-platform of high-throughput metabonomics, SNP array analysis, karyotype and mutation, the metabolic phenotypes and genomic polymorphisms of CML patients and their diverse responses to imatinib were characterized. The untreated CML patients (UCML) showed different metabolic patterns from those of healthy controls, and the discriminatory metabolites suggested the perturbed metabolism of the urea cycle, tricarboxylic acid cycle, lipid metabolism, and amino acid turnover in UCML. After imatinib treatment, patients sensitive to imatinib (SCML) and patients resistant to imatinib (RCML) had similar metabolic phenotypes to those of healthy controls and UCML, respectively. SCML showed a significant metabolic response to imatinib, with marked restoration of the perturbed metabolism. Most of the metabolites characterizing CML were adjusted to normal levels, including the intermediates of the urea cycle and tricarboxylic acid cycle (TCA). In contrast, neither cytogenetic nor metabonomic analysis indicated any positive response to imatinib in RCML. We report for the first time the associated genetic and metabonomic responses of CML patients to imatinib and show that the perturbed in vivo metabolism of UCML is independent of imatinib treatment in resistant patients. Thus, metabonomics can potentially characterize patients' sensitivity or resistance to drug intervention. PMID:20949032

Wang, Guangji; Yan, Bei; Zhang, Sujiang; Huang, Qing; Ni, Lingna; Zha, Weibin; Liu, Linsheng; Cao, Bei; Hong, Ming; Wu, Hanxin; Lu, Hua; Shi, Jian; Li, Mengjie; Li, Jianyong

2010-01-01

415

Identified motor terminals in Drosophila larvae show distinct differences in morphology and physiology  

Science.gov (United States)

In Drosophila, the type I motor terminals innervating the larval ventral longitudinal muscle fibers 6 and 7 have been the most popular preparation for combining synaptic studies with genetics. We have further characterized the normal morphological and physiological properties of these motor terminals and the influence of muscle size on terminal morphology. Using dye-injection and physiological techniques, we show that the two axons supplying these terminals have different innervation patterns: axon 1 innervates only muscle fibers 6 and 7, whereas axon 2 innervates all of the ventral longitudinal muscle fibers. This difference in innervation pattern allows the two axons to be reliably identified. The terminals formed by axons 1 and 2 on muscle fibers 6 and 7 have the same number of branches; however, axon 2 terminals are approximately 30% longer than axon 1 terminals, resulting in a corresponding greater number of boutons for axon 2. The axon 1 boutons are approximately 30% wider than the axon 2 boutons. The excitatory postsynaptic potential (EPSP) produced by axon 1 is generally smaller than that produced by axon 2, although the size distributions show considerable overlap. Consistent with vertebrate studies, there is a correlation between muscle fiber size and terminal size. For a single axon, terminal area and length, the number of terminal branches, and the number of boutons are all correlated with muscle fiber size, but bouton size is not. During prolonged repetitive stimulation, axon 2 motor terminals show synaptic depression, whereas axon 1 EPSPs facilitate. The response to repetitive stimulation appears to be similar at all motor terminals of an axon. Copyright 2000 John Wiley & Sons, Inc.

Lnenicka, G. A.; Keshishian, H.

2000-01-01

416

Mice lacking catalase develop normally but show differential sensitivity to oxidant tissue injury.  

Science.gov (United States)

Catalase plays a major role in cellular antioxidant defense by decomposing hydrogen peroxide, thereby preventing the generation of hydroxyl radical by the Fenton reaction. The degree of catalase deficiency in acatalasemic and hypocatalasemic mice varies from tissue to tissue. They therefore may not be suitable for studying the function of this enzyme in certain models of oxida