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1

A unified brittle fracture criterion for structures with sharp V-notches under mixed mode loading  

Energy Technology Data Exchange (ETDEWEB)

A unified brittle fracture criterion for cracks and V-notches under mixed mode loading is proposed by extending the maximum circumferential stress criterion and Novozhilov's criterion. The mixed mode fracture toughness and crack orientation of PMMA plates with a sharp V-notch are predicted by the proposed criterion. Tests were also carried out in order to investigate the mixed mode fracture of the PMMA plates. The fracture criterion is validated by comparison to experimental results

Kim, Jin Kwang; Cho, Sang Bong [Kyungnam University, Masan (Korea, Republic of)

2008-07-15

2

Results of charpy V-notch impact testing of structural steel specimens irradiated at {approximately}30{degrees}C to 1 x 10{sup 16} neutrons/cm{sup 2} in a commercial reactor cavity  

Energy Technology Data Exchange (ETDEWEB)

A capsule containing Charpy V-notch (CVN) and mini-tensile specimens was irradiated at {approximately} 30{degrees}C ({approximately} 85{degrees}F) in the cavity of a commercial nuclear power plant to a fluence of 1 x 10{sup 16} neutrons/cm{sup 2} (> 1MeV). The capsule included six CVN impact specimens of archival High Flux Isotope Reactor A212 grade B ferritic steel and five CVN impact specimens of a well-studied A36 structural steel. This irradiation was part of the ongoing study of neutron-induced damage effects at the low temperature and flux experienced by reactor supports. The plant operators shut down the plant before the planned exposure was reached. The exposure of these specimens produced no significant irradiation-induced embrittlement. Of interest were the data on unirradiated specimens in the L-T orientation machined from a single plate of A36 structural steel, which is the same specification for the structural steel used in some reactor supports. The average CVN energy of five unirradiated specimens obtained from one region of the plate and tested at room temperature was {approximately} 99 J, while the energy of 11 unirradiated specimens from other locations of the same plate was 45 J, a difference of {approximately} 220%. The CVN impact energies for all 18 specimens ranged from a low of 32 J to a high of 111 J. Moreover, it appears that the University of Kansas CVN impact energy data of the unirradiated specimens at the 100-J level are shifted toward higher temperatures by about 20 K. The results were an example of the extent of scatter possible in CVN impact testing. Generic values for the CVN impact energy of A36 should be used with caution in critical applications.

Iskander, S.K.; Stoller, R.E.

1997-04-01

3

Results of charpy V-notch impact testing of structural steel specimens irradiated at ?30 degrees C to 1 x 1016 neutrons/cm2 in a commercial reactor cavity  

International Nuclear Information System (INIS)

[en] A capsule containing Charpy V-notch (CVN) and mini-tensile specimens was irradiated at ? 30 degrees C (? 85 degrees F) in the cavity of a commercial nuclear power plant to a fluence of 1 x 1016 neutrons/cm2 (> 1MeV). The capsule included six CVN impact specimens of archival High Flux Isotope Reactor A212 grade B ferritic steel and five CVN impact specimens of a well-studied A36 structural steel. This irradiation was part of the ongoing study of neutron-induced damage effects at the low temperature and flux experienced by reactor supports. The plant operators shut down the plant before the planned exposure was reached. The exposure of these specimens produced no significant irradiation-induced embrittlement. Of interest were the data on unirradiated specimens in the L-T orientation machined from a single plate of A36 structural steel, which is the same specification for the structural steel used in some reactor supports. The average CVN energy of five unirradiated specimens obtained from one region of the plate and tested at room temperature was ? 99 J, while the energy of 11 unirradiated specimens from other locations of the same plate was 45 J, a difference of ? 220%. The CVN impact energies for all 18 specimens ranged from a low of 32 J to a high of 111 J. Moreover, it appears that the University of Kansas CVN impact energy data of the unirradiated specimens at the 100-J level are shifted toward higher temperatures by about 20 K. The results were an example of the extent of scatter possible in CVN impact testing. Generic values for the CVN impact energy of A36 should be used with caution in critical applications

1997-01-01

4

Use of forces from instrumented Charpy V-notch testing to determine crack-arrest toughness  

International Nuclear Information System (INIS)

The objective of this investigation is an estimation of the crack-arrest toughness, particularly of irradiated materials, from voltage versus time output of an instrumented setup during a test on a Charpy V-notch (CVN) specimen. This voltage versus time trace (which can be converted to force versus displacement) displays events during fracture of the specimen. Various stages of the fracture process can be identified on the trace, including an arrest point indicating arrest of brittle fracture. The force at arrest, Fa, versus test temperature, T, relationship is examined to explore possible relationships to other experimental measures of crack-arrest toughness such as the drop-weight nil-ductility temperature (NDT), or crack-arrest toughness, Ka. For a wide range of weld and plate materials, the temperature at which Fa = 2.45 kN correlates with NDT with a standard deviation, sigma, of about 11 K. Excluding the so-called low upper-shelf energy (USE) welds from the analysis resulted in Fa = 4.12 kN and ? = 6.6 K. The estimates of the correlation of the temperature for Fa = 7.4 kN with the temperature at 100-MPa?m level for a mean American Society of Mechanical Engineers (ASME) type KIa curve through crack-arrest toughness values show that prediction of conservative values of Ka are possible

1996-01-01

5

Correlation between the K{sub lc}, the HRc and the Charpy V-notch test results for H11/H13 hot-work tool steels at room temperature  

Energy Technology Data Exchange (ETDEWEB)

This investigation was conducted to determine whether there are correlations between CVN, HRc and K{sub Ic} test results at room temperature for AISI H11/H13 hot-work tool steel that could be developed to a tool for materials engineers and the structural designers. The results showed that such correlations do exist for electro-slag-remelted (ESR) and conventional AISI H11 hot-work tool steel. Static K{sub Ic} values were correlated with the results of standard CVN impact tests and the obtained hardness values at room temperature. Furthermore, the results show that the correlation can also be used to calculate K{sub Ic} values from standard CVN impact tests and the respective Rockwell-C hardness for AISI H13 tool steel. In general, the results of this investigation show that the correlation between the values of K{sub Ic}, CVN and HRc can be used to estimate the K{sub Ic} values from the CVN test results and the Rockwell-C hardness. (orig.)

Leskovsek, V. [Institute of Metals and Technology, Ljubljana (Slovenia)

2008-04-15

6

The Evolution of the Maine Lobster V-Notch Practice: Cooperation in a Prisoner's Dilemma Game  

Directory of Open Access Journals (Sweden)

Full Text Available The Maine lobster industry is experiencing record high catches because, in all probability, of an effective management program. One of the most important conservation measures is the V-notch program that allows fishermen to conserve proven breeding females by notching the tails of egg-bearing lobsters. Such marked lobsters may never be taken. Although thousands of lobster fishermen participate, it is a voluntary practice. The genesis of this practice is not easily explained, because V-notching poses a prisoner's dilemma problem that gives fishermen an incentive to avoid the practice. The most common explanations for ways to overcome prisoner's dilemma problems will not work in the case of the V-notch. An unusual combination of factors explains the V-notch program: (1) a strong belief among those in the industry that the V-notch is effective in conserving the lobster stock; (2) a low discount rate because the long-term gains from V-notching are higher than the one-time gain from defection; (3) a gain in reputation for those who V-notch. At the start of the 20th century, fishermen did not V-notch; by the end of the century, V-notching was common. We explain the change in strategies using a three-parameter evolutionary model that emphasizes the importance of culture change.

James Acheson; Roy Gardner

2011-01-01

7

Prediction method of fracture toughness K[sub IC] transition curve from Charpy V-notch impact test results. Sharupi shogeki shiken kekka kara no hakai zinsei K[sub IC] sen'i kyokusen no suitei hoho  

Energy Technology Data Exchange (ETDEWEB)

A number of studies on this subject has been performed up to the present and several prediction methods have been proposed. However those methods can not be always applied for all temperature in the transition temperature region. The authors have previously proposed the master curve method which can predict the fracture toughness K[sub IC] transition curve, by using Charpy absorption energy at the upper shelf temperature and 50% toughness fracture transition temperature (FATT). In this study, by expanding this method, in order to find out a method to be able to predict the fracture toughness K[sub IC] transition curve of the arbitrary materials, based on many published data in the past and 6 kinds of experimental results, the fracture toughness test results of 54 kinds of materials were analyzed. As a consequence, it was revealed that by using 0.2% bearing force gained by the energy at the upper shelf, FATT and the tension test, K[sub IC[minus

Iwadate, T.; Takemata, H. (The Japan Steel Works Ltd., Tokyo (Japan))

1992-08-15

8

Determination of the toughness of a low alloy steel from the Charpy V-notch impact testing  

International Nuclear Information System (INIS)

[en] Charpy V-notch (CVN) impact testing is widely used to characterize the resistance of a material to brittle fracture, by measuring the energy consumed by a specimen during impact. Notably materials undergoing a ductile-to-brittle transition, e.g. ferritic steels, are quality controlled by means of CVN testing, and their ductile-to-brittle transition temperature can be determined. Charpy testing is also widely used in the toughness assessment of large forged components, e.g. pressure vessels for pressurised water reactors (PWR). However, currently no satisfactory link between the Charpy impact energy CVN and the fracture toughness KIc exists. This study aims to establish a non-empirical relationship between the Charpy V-notch energy CVN, and the fracture toughness KIc, on the lower shelf of fracture toughness and the onset of the ductile-to-brittle transition of a A508 Cl.3 steel. The methodology employed is based on the so-called 'local approach'. Brittle cleavage fracture is modelled in terms of the Beremin (1983) model based on 'weakest link' statistics, whereas ductile crack advance preceding cleavage in the transition region is accounted for with the GTN model (Gurson, 1977; Tvergaard, 1982; Tvergaard and Needleman, 1984). Mechanical testing at different strain rates allowed for the establishment of the constitutive equations of the material in an elastic-viscoplastic formulation. Fracture tests on different specimen geometries provided the large data set necessary for statistical evaluation. All specimen types have been modelled with finite element analysis. However, the dynamic nature of the Charpy test requires special consideration. The origin of these dynamic effects was studied, as well as their implications on interpretation of experimental results and on modeling. After a proper modeling procedure had been defined, the local approach was employed for studying fracture. It is found that the fracture toughness can be predicted from the Charpy impact test, on the lower shelf. Towards higher fracture toughness, the parameters of the Beremin model change, losing their universality. Detailed fractographic investigations show that the nature of 'weak spots' inducing cleavage fracture changes with temperature. Furthermore, the local cleavage fracture stress acting on these 'weak spots' was found to change with temperature. The results are in agreement with those obtained by Renevey (1997) in a previous study on the same material. Thus it is concluded that the Beremin model must be refined in order to be applicable in the ductile-to-brittle transition region. (author)

1998-01-01

9

Weld investigations by 3D analyses of Charpy V-notch specimens  

DEFF Research Database (Denmark)

The Charpy impact test is a standard procedure for determining the ductile-brittle transition in welds. The predictions of such tests have been investigated by full three dimensional transient analyses of Charpy V-notch specimens. The material response is characterised by an elastic-viscoplastic constitutive relation for a porous plastic solid, accounting for adiabatic heating due to plastic dissipationfiand the resulting thermal softening. The onset of cleavage is taken to occur when the average of the maximum principal stress over a speci¯ed volume attains a critical value. Typically, the material parameters in the weld material differ from those in the base material, and the heat a®ected zone (HAZ) tends to be more brittle than the other material regions. The effect of weld strength undermatch or overmatch is an important issue. Some specimens, for which the notched surface is rotated relative to the surface of the test piece, have so complex geometry that only a full 3D analysis is able to account for theinteraction of failure in the three different material regions, whereas ther specimens can be approximated in terms of a planar analysis.

Tvergaard, Viggo; Needleman, Allan

2005-01-01

10

Material inertia and size effects in the Charpy V-notch test  

DEFF Research Database (Denmark)

The effect of material inertia on the size dependence of the absorbed energy in the Charpy V-notch test is investigated. The material response is characterized by an elastic-viscoplastic constitutive relation for a porous plastic solid, with adiabatic heating due to plastic dissipation and the resulting thermal softening accounted for. The onset of cleavage is taken to occur when a critical value of the maximum principal stress is attained over a critical volume. Plane strain dynamic analyses are carried out for geometrically similar specimens of various sizes with all parameters adjusted so that a quasi-static analysis would predict a size independent response. Sizes ranging from 1/4 to 16 times the ASTM standard size are analyzed and two sets of material properties are considered. No size effect is seen below a critical specimen size. Above this limit, a monotonic increase with specimen size is found for the normalized lower shelf energy (LSE) and the normalized upper shelf energy (USE) for both sets of material properties. The ductile-to-brittle transition temperature (DBTT) is found to increase monotonically with specimen size for one set of material properties, but a non-monotonic variation is found for the other set of material properties. (C) 2004 Elsevier SAS. All rights reserved.

Desandre, D. A.; Benzerga, A. A.

2004-01-01

11

CALIBRATION OF A 90 DEGREE V-NOTCH WEIR USING PARAMETERS OTHER THAN UPSTREAM HEAD  

Science.gov (United States)

Traditional calibration of 90 degrees V-Notch Weirs has involved the establishment of a head-discharge relationship where the head is measured upstream of weir drawdown effects. This parameter is often difficult to mesure in field weir installations. Two other parameters are prop...

12

Evaluation of fracture toughness in dental ceramics using indentation and SEVNB (Single Edge V-Notched Beam)-method  

International Nuclear Information System (INIS)

In this work, the fracture toughness of different ceramics based on Al2O3 and ZrO2 were evaluated using, comparatively two methods, Vickers indentation and SEVNB (Single Edge V-Notched Beam) method. Al2O3, ZrO2(3%Y2O3) micro-particled and ZrO2(3%Y2O3) nanometric, ZrO2-Al2O3 and Al2O3-ZrO2 composites were sintered at different temperatures. Samples were characterized by relative density, X-ray diffraction, SEM, and mechanical evaluation by hardness, bending strength and fracture toughness obtained by ickers indentation and SEVNB-method. The results were presented comparing the densification and microstructural results. Furthermore, the advantages and limitations of each method were discussed. (author)

2009-01-01

13

Dynamic analysis of the Charpy V-notch test  

International Nuclear Information System (INIS)

A computer simulation of a standard Charpy test from impact to the start of ductile tearing is reported. Both striker and specimens are modelled. The specimen is made of SA533 Grade B Class 1 nuclear-pressure-vessel steel and tested at 100 C. The results describe the wave interaction causing momentary separation of striker and specimen. The notch tip stress and strain at time of crack initiation are described, both for a plane-strain model and for the 1 cm thickness. The implications for correlation of total Charpy energy and initiation energy with fracture toughness are discussed

1981-01-01

14

Evaluation of fracture toughness in dental ceramics using indentation and SEVNB (Single Edge V-Notched Beam)-method; Avaliacao da tenacidade a fratura de ceramicas dentarias atraves do metodo de entalhe - SEVNB (Single Edge V-Notched Beam)  

Energy Technology Data Exchange (ETDEWEB)

In this work, the fracture toughness of different ceramics based on Al{sub 2}O{sub 3} and ZrO{sub 2} were evaluated using, comparatively two methods, Vickers indentation and SEVNB (Single Edge V-Notched Beam) method. Al{sub 2}O{sub 3}, ZrO{sub 2}(3%Y{sub 2}O{sub 3}) micro-particled and ZrO{sub 2}(3%Y{sub 2}O{sub 3}) nanometric, ZrO{sub 2}-Al{sub 2}O{sub 3} and Al{sub 2}O{sub 3}-ZrO{sub 2} composites were sintered at different temperatures. Samples were characterized by relative density, X-ray diffraction, SEM, and mechanical evaluation by hardness, bending strength and fracture toughness obtained by ickers indentation and SEVNB-method. The results were presented comparing the densification and microstructural results. Furthermore, the advantages and limitations of each method were discussed. (author)

Santos, L.A.; Santos, C.; Souza, R.C.; Ribeiro, S. [Universidade de Sao Paulo (DEMAR/EEL/USP), Lorena, SP (Brazil). Escola de Engenharia de Lorena. Dept. de Engenharia de Materiais. Polo Urbo-Industrial; Strecker, K. [Universidade Federal de Sao Joao del-Rei (DME/UFSJ), MG (Brazil). Dept. de Materiais Eletricos; Oberacker, R. [Karlsruhe Univ. (Germany)

2009-07-01

15

Analysis method of Charpy V-notch impact data before and after electron beam welding reconstitution  

International Nuclear Information System (INIS)

Research highlights: ? The EBW can be successful applied for reconstitution of the CVN specimens. ? The equality of DBTT was checked by t/t'-test with its uncertainty. ? The CVN data before and after reconstitution is in good agreement. - Abstract: The specimen reconstitution technique is one of the most promising techniques to improve the surveillance program of the reactor pressure vessel (RPV). In this study, unirradiated 30Mn2V low-alloy steels were chosen as the test materials, and the broken halves of Charpy V-notch impact (CVN) specimens were reconstituted to be new CVN specimens by the electron beam welding (EBW) as a pilot study in China. Taking the 20 insert reconstituted specimens as an example, Boltzmann function was used to fit the CVN data, the ductile-brittle transition temperature (DBTT) and its uncertainty were evaluated, and the equality of DBTT between the reconstituted specimens and original specimens was checked by t/t'-test. There is a great consistency between CVN data of EBW reconstituted specimens and that of original specimens.

2011-01-01

16

On impact testing of subsize Charpy V-notch type specimens  

International Nuclear Information System (INIS)

The potential for using subsize specimens to determine the actual properties of reactor pressure vessel steels is receiving increasing attention for improved vessel condition monitoring that could be beneficial for light-water reactor plant-life extension. This potential is made conditional upon, on the one hand, by the possibility of cutting samples of small volume from the internal surface of the pressure vessel for determination of actual properties of the operating pressure vessel. The plant-life extension will require supplemental surveillance data that cannot be provided by the existing surveillance programs. Testing of subsize specimens manufactured from broken halves of previously tested surveillance Charpy V-notch (CVN) specimens offers an attractive means of extending existing surveillance programs. Using subsize CVN type specimens requires the establishment of a specimen geometry that is adequate to obtain a ductile-to-brittle transition curve similar to that obtained from full-size specimens. This requires the development of a correlation of transition temperature and upper-shelf toughness between subsize and full-size specimens. The present study was conducted under the Heavy-Section Steel Irradiation Program. Different published approaches to the use of subsize specimens were analyzed and five different geometries of subsize specimens were selected for testing and evaluation. The specimens were made from several types of pressure vessel steels with a wide range of yield strengths, transition temperatures, and upper-shelf energies (USEs). Effects of specimen dimensions, including depth, angle, and radius of notch have been studied. The correlation of transition temperature determined from different types of subsize specimens and the full-size specimen is presented. A new procedure for transforming data from subsize specimens was developed and is presented

1994-01-01

17

Structural integrity for petrochemical vessels. Report on task 1: elasto-plastic finite element analysis of a charpy V-notch specimen  

Energy Technology Data Exchange (ETDEWEB)

The response of Charpy V-notch specimens under static loading for plane strain and plane stress conditions was examined using elasto-plastic finite element analysis. Five sets of material properties based on yield strength and hardening exponent were considered. The behaviour of the notch was studied, as well as the behaviour of the specimen up to the point of general yielding. Plots of non-dimensional stress vs. non-dimensional distance and non-dimensional load were presented. Peaks of the maximum principal stress were found at the same distance below the notch or slightly nearer the notch in the plane stress cases compared to plane strain cases. For the same material properties and loading conditions, plane stress analyses showed larger displacements and larger plastic zones than the plane strain analyses, which indicated general yielding occurred more readily under plane stress conditions. In both plane strain and plane stress, higher yield strengths and higher strain hardening exponents did not permit general yielding to be reached for the loads considered. 5 tabs., 68 figs, 10 refs.

McDill, M.

1993-03-01

18

Assessment of temper embrittlement in an ex-service 1Cr-1Mo-0.25V power generating rotor by Charpy V-Notch testing, KIc fracture toughness and small punch test  

International Nuclear Information System (INIS)

[en] This paper presents the results of the research aimed at developing fracture toughness correlations for the purposes of the remaining life assessment of an ex-service 1Cr-1Mo-0.25V power-generating rotor. Results from three methods of measuring the fracture toughness are presented and discussed: Charpy V-Notch testing, small punch testing and full size KIc testing. Samples were taken at three locations from a retired HP-IP rotor. De-embrittling and re-embrittling heat treatments were performed to generate three sets of samples: service-exposed, de-embrittled and re-embrittled. These samples were used to study the effect of temper embrittlement, a damage mechanism that reduces toughness of components in service. The correlations applied to the experimental data indicated advantages of using the small punch test as a miniature specimen technique for the remaining life assessment of low alloy steel rotors

2002-01-01

19

Effects of annealing time on the recovery of Charpy V-notch properties of irradiated high-copper weld metal  

International Nuclear Information System (INIS)

One of the options to mitigate the effects of irradiation on reactor pressure vessels is to thermally anneal them to restore the toughness properties that have been degraded by neutron irradiation. An important issue to be resolved is the effect on the toughness properties of reirradiating a vessel that has been annealed. This paper describes the annealing response of irradiated high-copper submerged-arc weld HSSI 73W. For this study, the weld has been annealed at 454 C (850 F) for lengths of time varying between 1 and 14 days. The Charpy V-notch 41-J (30-ft-lb) transition temperature (TT41J) almost fully recovered for the longest period studied, but recovered to a lesser degree for the shorter periods. No significant recovery of the TT41J was observed for a 7-day anneal at 343 C (650 F). At 454 C for the durations studied, the values of the upper-shelf impact energy of irradiated and annealed weld metal exceeded the values in the unirradiated condition. Similar behavior was observed after aging the unirradiated weld metal at 460 and 490 C for 1 week.

1994-01-01

20

Confocal microscopy-fracture reconstruction and finite element modeling characterization of local cleavage toughness in a ferritic/martensitic steel in subsized Charpy V-notch impact tests  

International Nuclear Information System (INIS)

The confocal microscopy (CM)-fracture reconstruction (FR) method, coupled with scanning electron microscopy (SEM) fractography, was used to measure the critical notch deformation conditions at cleavage initiation for two subsized Charpy V-notch (CVN) specimen geometries of Japan ferritic/martensitic steel (JFMS). A new method was developed to permit FR of notched specimens. Three-dimensional finite element analysis (FEA) simulations of the notch and specimen deformation were used to estimate values of critical micro-cleavage fracture stress, ?*, and critical stressed area, A*. Since ?*-A* is independent of size and geometry, it provides a fundamental local measure of cleavage toughness

2000-01-01

 
 
 
 
21

Astronomy Diagnostic Test Results Reflect Course Goals and Show Room for Improvement  

Science.gov (United States)

The results of administering the Astronomy Diagnostic Test (ADT) to introductory astronomy students at Henry Ford Community College over three years have shown gains comparable with national averages. Results have also accurately corresponded to course goals, showing greater gains in topics covered in more detail, and lower gains in topics covered…

LoPresto, Michael C.

2007-01-01

22

Radiofrequency microtenotomy for the treatment of plantar fasciitis shows good early results.  

UK PubMed Central (United Kingdom)

BACKGROUND: Microtenotomy coblation using a radiofrequency (RF) probe is a minimally invasive procedure for treating chronic tendinopathy. It has been described for conditions including tennis elbow and rotator cuff tendinitis. There have been no studies to show the effectiveness of such a procedure for plantar fasciitis. METHODS: 14 Patients with plantar fasciitis with failed conservative treatment underwent TOPAZ RF treatment for their symptoms between 2007 and 2008. The RF-based microdebridement was performed using the TOPAZ Microdebrider device (ArthroCare, Sunnyvale, CA). There were 6 men and 8 women with an average age of 44.0 years (23-57). There were 15 feet, with 6 right and 9 left feet. They were followed up for up to 6 months thereafter. Pre-operative, 3 and 6 months post-operative AOFAS ankle-hindfoot and SF-36 scores were analysed. RESULTS: There was a significant improvement in mean pre-operative, post-operative 3- and 6-month AOFAS hindfoot scores from 34.47 to 69.27 and 71.33 (p=0.00) respectively. There was a significant decrease in SF-36 for bodily pain, and significant increases in physical and social function scores. 12 out of 14 (85.7%) patients reported good to excellent satisfaction results at 6 months, and 12 out of 14 (85.7%) patients have had their expectations met from the procedure at 6 months follow up. CONCLUSION: TOPAZ RF coblation is a good and effective method for the treatment of recalcitrant plantar fasciitis. Early results are encouraging, and we will continue to assess the patients over a longer follow-up period.

Sean NY; Singh I; Wai CK

2010-12-01

23

Comparison of some results of program SHOW with other solar hot water computer programs  

Science.gov (United States)

Subroutines and the driver program for the simulation code SHOW (solar hot water) for solar thermosyphon systems are discussed, and simulations are compared with predictions by the F-CHART and TRNSYS codes. SHOW has the driver program MAIN, which defines the system control logic for choosing the appropriate system subroutine for analysis. Ten subroutines are described, which account for the solar system physical parameters, the weather data, the manufacturer-supplied system specifications, mass flow rates, pumped systems, total transformed radiation, load use profiles, stratification in storage, an electric water heater, and economic analyses. The three programs are employed to analyze a thermosiphon installation in Sacramento with two storage tanks. TRNSYS and SHOW were in agreement and lower than F-CHARt for annual predictions, although significantly more computer time was necessary to make TRNSYS converge.

Young, M. F.; Baughn, J. W.

24

Pilot evaluation of a media literacy program for tobacco prevention targeting early adolescents shows mixed results.  

UK PubMed Central (United Kingdom)

PURPOSE: The purpose of this pilot study was to assess the impact of media literacy for tobacco prevention for youth delivered through a community site. DESIGN: A randomized pretest-posttest evaluation design with matched-contact treatment and control conditions. SETTING: The pilot study was delivered through the YMCA in a lower-income suburban and rural area of Southwest Virginia, a region long tied, both economically and culturally, to the tobacco industry. SUBJECTS: Children ages 8 to 14 (76% white, 58% female) participated in the study (n = 38). INTERVENTION: The intervention was an antismoking media literacy program (five 1-hour lessons) compared with a matched-contact creative writing control program. MEASURES: General media literacy, three domains of tobacco-specific media literacy ("authors and audiences," "messages and meanings," and "representation and reality"), tobacco attitudes, and future expectations were assessed. ANALYSIS: Multiple regression modeling assessed the impact of the intervention, controlling for pretest measures, age, and sex. RESULTS: General media literacy and tobacco-specific "authors and audiences" media literacy improved significantly for treatment compared with control (p < .05); results for other tobacco-specific media literacy measures and for tobacco attitudes were not significant. Future expectations of smoking increased significantly for treatment participants ages 10 and younger (p < .05). CONCLUSION: Mixed results indicated that improvements in media literacy are accompanied by an increase in future expectations to smoke for younger children.

Kaestle CE; Chen Y; Estabrooks PA; Zoellner J; Bigby B

2013-07-01

25

Lung cancer trial results show mortality benefit with low-dose CT:  

Science.gov (United States)

The NCI has released initial results from a large-scale test of screening methods to reduce deaths from lung cancer by detecting cancers at relatively early stages. The National Lung Screening Trial, a randomized national trial involving more than 53,000 current and former heavy smokers ages 55 to 74, compared the effects of two screening procedures for lung cancer -- low-dose helical computed tomography (CT) and standard chest X-ray -- on lung cancer mortality and found 20 percent fewer lung cancer deaths among trial participants screened with low-dose helical CT.

26

FES Training in Aging: interim results show statistically significant improvements in mobility and muscle fiber size  

Directory of Open Access Journals (Sweden)

Full Text Available Aging is a multifactorial process that is characterized by decline in muscle mass and performance. Several factors, including reduced exercise, poor nutrition and modified hormonal metabolism, are responsible for changes in the rates of protein synthesis and degradation that drive skeletal muscle mass reduction with a consequent decline of force generation and mobility functional performances. Seniors with normal life style were enrolled: two groups in Vienna (n=32) and two groups in Bratislava: (n=19). All subjects were healthy and declared not to have any specific physical/disease problems. The two Vienna groups of seniors exercised for 10 weeks with two different types of training (leg press at the hospital or home-based functional electrical stimulation, h-b FES). Demografic data (age, height and weight) were recorded before and after the training period and before and after the training period the patients were submitted to mobility functional analyses and muscle biopsies. The mobility functional analyses were: 1. gait speed (10m test fastest speed, in m/s); 2. time which the subject needed to rise from a chair for five times (5x Chair-Rise, in s); 3. Timed –Up-Go- Test, in s; 4. Stair-Test, in s; 5. isometric measurement of quadriceps force (Torque/kg, in Nm/kg); and 6. Dynamic Balance in mm. Preliminary analyses of muscle biopsies from quadriceps in some of the Vienna and Bratislava patients present morphometric results consistent with their functional behaviors. The statistically significant improvements in functional testings here reported demonstrates the effectiveness of h-b FES, and strongly support h-b FES, as a safe home-based method to improve contractility and performances of ageing muscles.

Helmut Kern; Stefan Loefler; Christian Hofer; Michael Vogelauer; Samantha Burggraf; Martina Grim-Stieger; Jan Cvecka; Dusan Hamar; Nejc Sarabon; Feliciano Protasi; Antonio Musarò; Marco Sandri; Katia Rossini; Ugo Carraro; Sandra Zampieri

2012-01-01

27

News Note: Long-term Results from Study of Tamoxifen and Raloxifene Shows Lower Toxicities of Raloxifene  

Science.gov (United States)

Initial results in 2006 of the NCI-sponsored Study of Tamoxifen and Raloxifene (STAR) showed that a common osteoporosis drug, raloxifene, prevented breast cancer to the same degree, but with fewer serious side-effects, than the drug tamoxifen that had been in use many years for breast cancer prevention as well as treatment. The longer-term results show that raloxifene retained 76 percent of the effectiveness of tamoxifen in preventing invasive disease and grew closer to tamoxifen in preventing noninvasive disease, while remaining far less toxic – in particular, there was significantly less endometrial cancer with raloxifene use.

28

Effects of oxidation on the impact energy of Hastelloy S and Hastelloy C-4 Charpy V-notch specimens heated in air at 6000 to 8000C  

International Nuclear Information System (INIS)

The 90SrF2 heat source being developed at PNL utilizes a Hastelloy S or Hastelloy C-4 outer capsule having a 0.5-in.-thick wall to contain the Hastelloy C-276 inner capsule. The primary objective of the study was to demonstrate that the air oxidation of the outer capsule that could occur during heat-source service would not degrade the ductility and Charpy impact strength of the capsule below the licensing requirements given in Section 1.1. The 90SrF2 heat source under development is intended for general-purpose use. Compatibility considerations limit the interface temperature between the 90SrF2 and Hastelloy C-276 inner capsule to a maximum of 8000C. The outer capsule surface temperature will be somewhat less than 8000C, and depending on the service, may be substantially lower. The oxidation tests were therefore carried out at 6000 to 8000C for exposures up to 10,000h to cover the range of temperature the outer capsule might expect to encounter in service. The results showed that the oxidation of Hastelloy S and Hastelloy C-4 in air at 6000 to 8000C is very slow, and both alloys form adherent oxide layers that serve to protect the underlying metal. Subsurface attack of Hastelloy S and Hastelloy C-4 due to oxidation was greater than expected, considering the slow oxidation rates of the two alloys at 6000 to 8000C. Estimates of subsurface attack, determined from micrographs of the oxidized specimens, showed erratic results and it was impossible to assign any type of rate equation to the subsurface attack. A conservative estimate of long-term effects can be made using a linear extrapolation of the test results. There were no significant differences between the room-temperature Charpy impact energy of Hastelloy S and Hastelloy C-4 specimens oxidized in air at 6000 to 8000C and control specimens heated in vacuum

1981-01-01

29

Effects of oxidation on the impact energy of Hastelloy S and Hastelloy C-4 Charpy V-notch specimens heated in air at 600 to 800  

Energy Technology Data Exchange (ETDEWEB)

The /sup 90/SrF/sub 2/ heat source being developed at PNL utilizes a Hastelloy S or Hastelloy C-4 outer capsule having a 0.5-in.-thick wall to contain the Hastelloy C-276 inner capsule. The primary objective of the study was to demonstrate that the air oxidation of the outer capsule that could occur during heat-source service would not degrade the ductility and Charpy impact strength of the capsule below the licensing requirements given in Section 1.1. The /sup 90/SrF/sub 2/ heat source under development is intended for general-purpose use. Compatibility considerations limit the interface temperature between the /sup 90/SrF/sub 2/ and Hastelloy C-276 inner capsule to a maximum of 800/sup 0/C. The outer capsule surface temperature will be somewhat less than 800/sup 0/C, and depending on the service, may be substantially lower. The oxidation tests were therefore carried out at 600/sup 0/ to 800/sup 0/C for exposures up to 10,000h to cover the range of temperature the outer capsule might expect to encounter in service. The results showed that the oxidation of Hastelloy S and Hastelloy C-4 in air at 600/sup 0/ to 800/sup 0/C is very slow, and both alloys form adherent oxide layers that serve to protect the underlying metal. Subsurface attack of Hastelloy S and Hastelloy C-4 due to oxidation was greater than expected, considering the slow oxidation rates of the two alloys at 600/sup 0/ to 800/sup 0/C. Estimates of subsurface attack, determined from micrographs of the oxidized specimens, showed erratic results and it was impossible to assign any type of rate equation to the subsurface attack. A conservative estimate of long-term effects can be made using a linear extrapolation of the test results. There were no significant differences between the room-temperature Charpy impact energy of Hastelloy S and Hastelloy C-4 specimens oxidized in air at 600/sup 0/ to 800/sup 0/C and control specimens heated in vacuum.

Fullam, H.T.

1981-01-01

30

Reception of Talent Shows in Denmark: First Results from a Trans-National Audience Study of a Global Format Genre  

DEFF Research Database (Denmark)

This paper will discuss the methodology and present the preliminary findings of the Danish part of a trans-national, comparative audience study of the musical talent show genre undertaken in Denmark, Finland, Germany and Great Britain in Spring 2013. Within the international business model of format adaptation, the musical talent show genre has been particularly successful in crossing cultural borders. Formats such as Idols, X Factor and Voice have sold to a large variety of countries, covering all continents. Such global reach inevitably raises the question of the genre’s audience appeal; to what degree its reach has to do with a universal appeal inherent in the genre and/or the innovative character of individual formats, and to what degree its global success is due to local broadcasters’ ability to successfully adapt the formats to local audience tastes. A consensus has developed that television formats to a considerable degree are adapted according to national audiences and, hence, national cultural tastes. And in our research approach, we do recognize that musical talent shows appear to contribute to ‘imagining the nation’ (Anderson 1983), often even mentioning the nation in the title. However, we also take into account that the national perspective needs to be considered critically. First, there are other factors but national culture that determine a local adaptation such as subnational target groups, channel identity, financing or chance incidents. Secondly, it has rightly been argued that within any national television market, especially in the post-broadcast era, a multiplicity of publics co-exists. The aim of the focus groups is therefore to shed light on the complexity of the communal viewing experience, real and imagined, national, sub-national and transnational; of identification, and of the meaning that viewers take from the musical talent show genre.

Jensen, Pia Majbritt

31

Resistin polymorphisms show associations with obesity, but not with bone parameters in men : results from the Odense Androgen Study  

DEFF Research Database (Denmark)

Resistin is an obesity-related adipokine which has also been implicated in bone metabolism. Therefore, we designed a study to investigate the possible role of resistin gene variation in both obesity and bone mineral density. We included 1,155 individuals from the Odense Androgen Study (663 young subjects and 492 older subjects), a population-based, prospective, observational study on the inter-relationship between endocrine status, body composition, muscle function, and bone metabolism in men, in an association study with resistin (RETN) polymorphisms. Three RETN variants (rs1862513, rs3745367 and rs3745369) were genotyped with TaqMan Pre-Designed Genotyping assays. Linear regression was performed to investigate the possible association of these variants with several obesity- and bone-related parameters. After genotyping 1,155 Danish men, 663 young subjects and 492 older subjects, we found that rs3745367 was associated with several obesity-related measures in both the young and elderly cohort. Rs3745369 was only associated with obesity-phenotypes in the elderly cohort. When studying the combined cohorts, we could confirm the associations of rs3745367 with several obesity-related parameters. We were unable to identify any association between RETN polymorphisms and bone-related measurements. Together, these results illustrate resistin's role in the development of obesity. Rs3745367 gives the most consistent results in the current study and these should be confirmed in other populations. Research into its possible functional effect might also be required. A role for RETN variants in determining bone mineral density seems unlikely from our results.

Beckers, Sigri; Zegers, Doreen

2013-01-01

32

Acute pain: individual patient meta-analysis shows the impact of different ways of analysing and presenting results.  

UK PubMed Central (United Kingdom)

Individual patient meta-analysis using information from clinically homogeneous acute pain trials with observations over 24h was used to investigate different ways trials can be analysed and reported. There were 13 third-molar extraction trials, with 1,330 patients using rofecoxib 50mg, 303 using ibuprofen 400mg, and 570 using placebo. Pain relief scores were available at individual time points, plus time to remedication. Many more patients remedicated with placebo than ibuprofen 400mg, and more with ibuprofen than rofecoxib 50mg. Median time to remedication, the proportion remedicated at various times, or survival curves would be useful outcomes. In dealing with missing data points when patients remedicated, baseline observation carried forward was more conservative than last observation carried forward, resulting in higher (worse) NNTs and lower average pain scores after 12 and 24h. Results based on both methods might be sensible for trials longer than eight hours. The distribution of pain relief was highly skewed, especially at later times, when almost no patient was average. Different cut points for pain relief (at least 25, 50 or 75% maxTOTPAR) and longer duration changed the NNT for ibuprofen compared with placebo, but less for rofecoxib, reflecting longer duration of action of rofecoxib. Reporting for each treatment group the percentage of patients with 25, 50 and 75% pain relief at various times after dose, and reporting the proportion of patients with good or complete pain relief, and inadequate pain relief, at each time point, would improve acute pain trial reporting.

Moore RA; Edwards JE; McQuay HJ

2005-08-01

33

Medicaid incentive programs to encourage healthy behavior show mixed results to date and should be studied and improved.  

UK PubMed Central (United Kingdom)

In September 2011 the Centers for Medicare and Medicaid Services awarded $85 million in grants to ten states to test financial incentive programs to encourage healthy behavior among Medicaid enrollees with chronic diseases. There is little published evidence about the effectiveness of such incentives within the Medicaid program. We evaluated the available research from three earlier Medicaid incentive programs and found mixed results. On the one hand, in Florida only about half of the $41.3 million in available credits was "claimed" by enrollees between 2006 and 2011. On the other, Idaho's incentive program was credited with improving the proportion of children who were up-to-date on well-child visits. Our findings suggest that Medicaid incentive programs should be designed so that enrollees can understand them and so that the incentives are attractive enough to motivate participation. Medicaid incentive programs also should be subject to rigorous evaluation to more clearly establish their effectiveness.

Blumenthal KJ; Saulsgiver KA; Norton L; Troxel AB; Anarella JP; Gesten FC; Chernew ME; Volpp KG

2013-03-01

34

Results of crack-arrest tests on two irradiated high-copper welds  

Energy Technology Data Exchange (ETDEWEB)

The objective of this study was to determine the effect of neutron irradiation on the shift and shape of the lower-bound curve to crack-arrest data. Two submerged-arc welds with copper contents of 0.23 and 0.31 wt % were commercially fabricated in 220-mm-thick plate. Crack-arrest specimens fabricated from these welds were irradiated at a nominal temperature of 288{degree}C to an average fluence of 1.9 {times} 10{sup 19} neutrons/cm{sup 2} (>1 MeV). Evaluation of the results shows that the neutron-irradiation-induced crack-arrest toughness temperature shift is about the same as the Charpy V-notch impact temperature shift at the 41-J energy level. The shape of the lower-bound curves (for the range of test temperatures covered) did not seem to have been altered by irradiation compared to those of the ASME K{sub Ia} curve. 9 refs., 21 figs., 10 tabs.

Iskander, S.K.; Corwin, W.R.; Nanstead, R.K. (Oak Ridge National Lab., TN (USA))

1990-12-01

35

Long-range energy efficiency agreements show results in the foundry sector in the Netherlands; Meerjarenafspraken werpen resultaten af in gieterijbranche  

Energy Technology Data Exchange (ETDEWEB)

A brief overview is given of the results of the long-range energy efficiency agreement (MJA, abbreviated in Dutch) between the Dutch government and the foundry sector. [Dutch] Een kort overzicht wordt gegeven van de resultaten van de meerjarenafspraak (MJA) tussen het Ministerie van Economische Zaken en de gieterijen sector.

Koppenol, T. [Rommelse Communicatieadvies, Velserbroek (Netherlands)

2003-04-01

36

Combination modality therapy in lung cancer: a survival study showing beneficial results of AMCOF (adriamycin, methotrexate, cyclophosphamide, oncovin and 5-fluorouracil).  

UK PubMed Central (United Kingdom)

Thirty-seven patients with advanced or recurrent lung cancer were randomized to cytoxan (CTX) alone, COMF (CTX, oncovin, methotrecate and 5-FU) or AMCOF (adriamycin, methotrexate, CTX, oncovin and 5-FU) after receiving radiation therapy to primary and bulky tumor sites. Median survival was 3 months for CTX, 6 months for COMF and 14 months for AMCOF. Analysis of those with cell (small cell) carcinoma showed median survival of 8.5 months. Oat cell cases treated with CTX survived 5 months (8 patients) with COMF 7.5 months (15 patients) and with AMCOF 13 months (14 patients). The median survival of those with adenocarcinoma or epidermoid carcinoma treated with CTX survived 3 months, with COMF 6 months and with AMCOF 15.5 months. Toxicity was moderate though no life-theatening toxicity developed in spite of the protocol design of escalation to achieve some degree of hematologic toxicity in all patients.

Reynolds RD; O'Dell S

1978-08-01

37

Genetic susceptibility to childhood acute lymphoblastic leukemia shows protection in Malay boys: results from the Malaysia-Singapore ALL Study Group.  

UK PubMed Central (United Kingdom)

To study genetic epidemiology of childhood acute lymphoblastic leukemia (ALL) in the Chinese and Malays, we investigated 10 polymorphisms encoding carcinogen- or folate-metabolism and transport. Sex-adjusted analysis showed NQO1 609CT significantly protects against ALL, whilst MTHFR 677CT confers marginal protection. Interestingly, we observed that NQO1 609CT and MTHFR 1298 C-allele have greater genetic impact in boys than in girls. The combination of SLC19A1 80GA heterozygosity and 3'-TYMS -6bp/-6bp homozygous deletion is associated with reduced ALL risk in Malay boys. Our study has suggested the importance of gender and race in modulating ALL susceptibility via the folate metabolic pathway.

Yeoh AE; Lu Y; Chan JY; Chan YH; Ariffin H; Kham SK; Quah TC

2010-03-01

38

Genetic susceptibility to childhood acute lymphoblastic leukemia shows protection in Malay boys: results from the Malaysia-Singapore ALL Study Group.  

Science.gov (United States)

To study genetic epidemiology of childhood acute lymphoblastic leukemia (ALL) in the Chinese and Malays, we investigated 10 polymorphisms encoding carcinogen- or folate-metabolism and transport. Sex-adjusted analysis showed NQO1 609CT significantly protects against ALL, whilst MTHFR 677CT confers marginal protection. Interestingly, we observed that NQO1 609CT and MTHFR 1298 C-allele have greater genetic impact in boys than in girls. The combination of SLC19A1 80GA heterozygosity and 3'-TYMS -6bp/-6bp homozygous deletion is associated with reduced ALL risk in Malay boys. Our study has suggested the importance of gender and race in modulating ALL susceptibility via the folate metabolic pathway. PMID:19651439

Yeoh, Allen Eng-Juh; Lu, Yi; Chan, Jason Yong-Sheng; Chan, Yiong Huak; Ariffin, Hany; Kham, Shirley Kow-Yin; Quah, Thuan Chong

2009-08-03

39

A second generation cervico-vaginal lavage device shows similar performance as its preceding version with respect to DNA yield and HPV DNA results  

Science.gov (United States)

Background Attendance rates of cervical screening programs can be increased by offering HPV self-sampling to non-attendees. Acceptability, DNA yield, lavage volumes and choice of hrHPV test can influence effectiveness of the self-sampling procedures and could therefore play a role in recruiting non-attendees. To increase user-friendliness, a frequently used lavage sampler was modified. In this study, we compared this second generation lavage device with the first generation device within similar birth cohorts. Methods Within a large self-sampling cohort-study among non-responders of the Dutch cervical screening program, a subset of 2,644 women received a second generation self-sampling lavage device, while 11,977 women, matched for age and ZIP-code, received the first generation model. The second generation device was different in shape, color, lavage volume, and packaging, in comparison to its first generation model. The Cochran’s test was used to compare both devices for hrHPV positivity rate and response rate. To correct for possible heterogeneity between age and ZIP codes in both groups the Breslow-Day test of homogeneity was used. A T-test was utilized to compare DNA yields of the obtained material in both groups. Results Median DNA yields were 90.4 ?g/ml (95% CI 83.2-97.5) and 91.1 ?g/ml (95% CI 77.8-104.4, p= 0.726) and hrHPV positivity rates were 8.2% and 6.9% (p= 0.419) per sample self-collected by the second - and the first generation of the device (p= 0.726), respectively. In addition, response rates were comparable for the two models (35.4% versus 34.4%, p= 0.654). Conclusions Replacing the first generation self-sampling device by an ergonomically improved, second generation device resulted in equal DNA yields, comparable hrHPV positivity rates and similar response rates. Therefore, it can be concluded that the clinical performance of the first and second generation models are similar. Moreover, participation of non-attendees in cervical cancer screening is probably not predominantly determined by the type of self-collection device.

2013-01-01

40

The Diane Rehm Show  

Science.gov (United States)

The Diane Rehm Show has its origins in a mid-day program at WAMU in Washington, D.C. Diane Rehm came on to host the program in 1979, and in 1984 it was renamed "The Diane Rehm Show". Over the past several decades, Rehm has played host to hundreds of guests, include Archbishop Desmond Tutu, Julie Andrews, and President Bill Clinton. This website contains an archive of her past programs, and visitors can use the interactive calendar to look through past shows. Those visitors looking for specific topics can use the "Topics" list on the left-hand side of the page, or also take advantage of the search engine. The show has a number of social networking links, including a Facebook page and a Twitter feed.

 
 
 
 
41

Ultrasonography-guided core needle biopsy for the thyroid nodule: does the procedure hold any benefit for the diagnosis when fine-needle aspiration cytology analysis shows inconclusive results?  

UK PubMed Central (United Kingdom)

OBJECTIVE: We evaluated the diagnostic role of ultrasonography-guided core needle biopsy (CNB) according to ultrasonography features of thyroid nodules that had inconclusive ultrasonography-guided fine-needle aspiration (FNA) results. METHODS: A total of 88 thyroid nodules in 88 patients who underwent ultrasonography-guided CNB because of previous inconclusive FNA results were evaluated. The patients were classified into three groups based on ultrasonography findings: Group A, which was suspicious for papillary thyroid carcinoma (PTC); Group B, which was suspicious for follicular (Hurthle cell) neoplasm; and Group C, which was suspicious for lymphoma. The final diagnoses of the thyroid nodules were determined by surgical confirmation or follow-up after ultrasonography-guided CNB. RESULTS: Of the 88 nodules, the malignant rate was 49.1% in Group A, 12.0% in Group B and 90.0% in Group C. The rates of conclusive ultrasonography-guided CNB results after previous incomplete ultrasonography-guided FNA results were 96.2% in Group A, 64.0% in Group B and 90.0% in Group C (p=0.001). 12 cases with inconclusive ultrasonography-guided CNB results were finally diagnosed as 8 benign lesions, 3 PTCs and 1 lymphoma. The number of previous ultrasonography-guided FNA biopsies was not significantly different between the conclusive and the inconclusive result groups of ultrasonography-guided CNB (p=0.205). CONCLUSION: Ultrasonography-guided CNB has benefit for the diagnosis of thyroid nodules with inconclusive ultrasonography-guided FNA results. However, it is still not helpful for the differential diagnosis in 36% of nodules that are suspicious for follicular neoplasm seen on ultrasonography. Advances in knowledge: This study shows the diagnostic contribution of ultrasonography-guided CNB as an alternative to repeat ultrasonography-guided FNA or surgery.

Hahn SY; Shin JH; Han BK; Ko EY; Ko ES

2013-05-01

42

Multi-functional and portable hygiene and diagnostic kit for use during e.g. sporting activity, has agents and tampons provided as diagnostic and therapeutic unit to provide test results and show indications of infections  

UK PubMed Central (United Kingdom)

The kit has an in-vitro diagnostic agent indicating inflammation parameters of a vagina and urine, and determining parameters of a vaginal pH value of leukocyte and nitride. A vaginal therapeutic agent i.e. gel, with probiotic agents is applied for healthy regeneration of vaginal flora. Tampons include a probiotic preparation e.g. lacto-bacilli. The kit is designed in the form of a pouch. The agents and tampons is provided as a diagnostic and therapeutic unit to provide test results of a user and show indications of infections in an uro-genital tract.

FAUST BRIGITTE; NEUMANN GERD

43

Reality, ficción o show  

Directory of Open Access Journals (Sweden)

Full Text Available Para tener un punto de vista claro y objetivo frente a la polémica establecida en torno al programa ?Protagonistas de novela? y la tendiente proliferación de los reality show en las parrillas de programación de la televisión colombiana, se realizó un análisis de texto y contenido de dicho programa, intentando definirlo desde sus posibilidades de realidad, ficción y show. Las unidades de análisis y el estudio de su tratamiento arrojaron un alto contenido que gira en torno a las emociones del ser humano relacionadas con la convivencia, tratadas a manera de show y con algunos aportes textuales de ficción, pero sin su elemento mediador básico, el actor, quitándole toda la posibilidad de tener un tratamiento con la profundidad, distancia y ética que requieren los temas de esta índole. El resultado es un formato que sólo busca altos índices de sintonía y que pertenece más a la denominada televisión ?trash?, que a una búsqueda de realidad del hombre y mucho menos de sociedad.

Sandra Ruíz Moreno

2002-01-01

44

Not a "reality" show.  

UK PubMed Central (United Kingdom)

The authors of the preceding articles raise legitimate questions about patient and staff rights and the unintended consequences of allowing ABC News to film inside teaching hospitals. We explain why we regard their fears as baseless and not supported by what we heard from individuals portrayed in the filming, our decade-long experience making medical documentaries, and the full un-aired context of the scenes shown in the broadcast. The authors don't and can't know what conversations we had, what documents we reviewed, and what protections we put in place in each televised scene. Finally, we hope to correct several misleading examples cited by the authors as well as their offhand mischaracterization of our program as a "reality" show.

Wrong T; Baumgart E

2013-01-01

45

Do combined alternating sessions of 1540 nm nonablative fractional laser and percutaneous collagen induction with trichloroacetic acid 20% show better results than each individual modality in the treatment of atrophic acne scars? A randomized controlled trial.  

UK PubMed Central (United Kingdom)

Background: There have been no well-controlled studies evaluating the efficacy of combining 1540 nm nonablative fractional laser with percutaneous collagen induction (PCI) and trichloroacetic acid (TCA) 20% in the treatment of atrophic acne scars. Objective: We hypothesized that combined alternating sessions of both modalities would show better results than each individual modality. Methods and materials: Thirty-nine patients with post acne atrophic scars were included in this study. Patients were randomly equally divided into three groups; group 1 was subjected to six sessions of PCI combined with TCA 20% in the same session, group 2 was subjected to six sessions of 1540 nm fractional laser and group 3 was subjected to combined alternating sessions of the previously mentioned two modalities. Results: Scar severity scores improved by a mean of 59.79% (95% CI 47.38-72.21) (p < 0.001) in group 1, a mean of 61.83% (95% CI 54.09-69.56) (p < 0.001) in group 2 and a mean of 78.27% (95% CI 74.39-82.15) (p < 0.001) in group 3. The difference in the degree of improvement was statistically significant when comparing the three groups using ANOVA test (p = 0.004). Conclusion: The current work recommends combining 1540 nm nonablative fractional laser in alternation with PCI and TCA 20% in the treatment of atrophic acne scars.

Leheta TM; Abdel Hay RM; Hegazy RA; El Garem YF

2012-07-01

46

Dietary fiber showed no preventive effect against colon and rectal cancers in Japanese with low fat intake: an analysis from the results of nutrition surveys from 23 Japanese prefectures  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract Background Since Fuchs' report in 1999, the reported protective effect of dietary fiber from colorectal carcinogenesis has led many researchers to question its real benefit. The aim of this study is to evaluate the association between diet, especially dietary fiber and fat and colorectal cancer in Japan. Methods A multiple regression analysis (using the stepwise variable selection method) was performed using the standardized mortality ratios (SMRs) of colon and rectal cancer in 23 Japanese prefectures as objective variables and dietary fiber, nutrients and food groups as explanatory variables. Results As for colon cancer, the standardized partial correlation coefficients were positively significant for fat (1,13, P = 0.000), seaweeds (0.41, P = 0.026) and beans (0.45, P = 0.017) and were negatively significant for vitamin A (-0.63, P = 0.003), vitamin C (-0.42, P = 0.019) and yellow-green vegetables (-0.37, P = 0.046). For rectal cancer, the standardized partial correlation coefficient in fat (0.60, P = 0.002) was positively significant. Dietary fiber was not found to have a significant relationship with either colon or rectal cancers. Conclusions This study failed to show any protective effect of dietary fiber in subjects with a low fat intake (Japanese) in this analysis, which supports Fuchs' findings in subjects with a high fat intake (US Americans).

Nakaji Shigeyuki; Shimoyama Tadashi; Umeda Takashi; Sakamoto Juichi; Katsura Shuji; Sugawara Kazuo; Baxter David

2001-01-01

47

Results of crack-arrest tests on irradiated a 508 class 3 steel  

International Nuclear Information System (INIS)

Ten crack-arrest toughness values for irradiated specimens of A 508 class 3 forging steel have been obtained. The tests were performed according to the American Society for Testing and Materials (ASTM) Standard Test Method for Determining Plane-Strain Crack-Arrest Fracture Toughness, Kla of Ferritic Steels, E 1221-88. None of these values are strictly valid in all five ASTM E 1221-88 validity criteria. However, they are useful when compared to unirradiated crack-arrest specimen toughness values since they show the small (averaging approximately 10 degrees C) shifts in the mean and lower-bound crack-arrest toughness curves. This confirms that a low copper content in ASTM A 508 class 3 forging material can be expected to result in small shifts of the transition toughness curve. The shifts due to neutron irradiation of the lower bound and mean toughness curves are approximately the same as the Charpy V-notch (CVN) 41-J temperature shift. The nine crack-arrest specimens were irradiated at temperatures varying from 243 to 280 degrees C, and to a fluence varying from 1.7 to 2.7 x 1019 neutrons/cm2 (> 1 MeV). The test results were normalized to reference values that correspond to those of CVN specimens irradiated at 284 degrees C to a fluence of 3.2 x 1019 neutrons/cm2 (> 1 MeV) in the same capsule as the crack-arrest specimens. This adjustment resulted in a shift to lower temperatures of all the data, and in particular moved two data points that appeared to lie close to or lower than the American Society of Mechanical Engineers Kla curve to positions that seemed more reasonable with respect to the remaining data. A special fixture was designed, fabricated, and successfully used in the testing. For reasons explained in the text, special blocks to receive the Oak Ridge National Laboratory clip gage were designed, and greater-than-standard crack-mouth opening displacements measured were accounted for. 24 refs., 13 figs., 12 tabs.

1998-01-01

48

2-Year follow-up to STeP trial shows sustainability of structured self-monitoring of blood glucose utilization: results from the STeP practice logistics and usability survey (STeP PLUS).  

UK PubMed Central (United Kingdom)

We report findings from a follow-up survey of clinicians from the STeP study that assessed their attitudes toward and current use of the Accu-Chek(®) 360° View tool (Roche Diagnostics, Indianapolis, IN) approximately 2 years after the study was completed. The Accu-Chek 360° View tool enables patients to record/plot a seven-point self-monitoring of blood glucose (SMBG) profile (fasting, preprandial/2-h postprandial at each of the three meals, and bedtime) on 3 consecutive days, document meal sizes and energy levels, and comment on their SMBG experiences. Our findings showed that the majority of these physicians continue to use the tool with their patients, citing enhanced patient understanding and engagement, better discussions with patients regarding the impact of lifestyle behaviors, improved clinical outcomes, and better practice efficiencies as significant benefits of the tool.

Friedman K; Noyes J; Parkin CG

2013-04-01

49

The S locus-linked Primula homeotic mutant sepaloid shows characteristics of a B-function mutant but does not result from mutation in a B-function gene.  

Science.gov (United States)

Floral homeotic and flower development mutants of Primula, including double, Hose in Hose, Jack in the Green and Split Perianth, have been cultivated since the late 1500s as ornamental plants but until recently have attracted limited scientific attention. Here we describe the characterization of a new mutant phenotype, sepaloid, that produces flowers comprising only sepals and carpels. The sepaloid mutation is recessive, and is linked to the S locus that controls floral heteromorphy. The phenotype shows developmental variability, with flowers containing three whorls of sepals surrounding fertile carpels, two whorls of sepals with a diminished third whorl of sepals surrounding a fourth whorl of carpels, or three whorls of sepals surrounding abnormal carpels. In some respects, these phenotypes resemble the Arabidopsis and Antirrhinum homeotic B-function mutants apetala3/deficiens (ap3/def) and pistillata/globosa (pi/glo). We have isolated the Primula vulgaris B-function genes PvDEFICIENS (PvDEF) and PvGLOBOSA (PvGLO), expression of both of which is affected in the sepaloid mutant. PvGLO, like sepaloid, is linked to the S locus, whereas PvDEF is not. However, our analyses reveal that sepaloid and PvGLO represent different genes. We conclude that SEPALOID is an S-linked independent regulator of floral organ identity genes including PvDEF and PvGLO. PMID:18564384

Li, Jinhong; Webster, Margaret; Dudas, Brigitta; Cook, Holly; Manfield, Iain; Davies, Brendan; Gilmartin, Philip M

2008-06-28

50

The "Life Potential": a new complex algorithm to assess "Heart Rate Variability" from Holter records for cognitive and diagnostic aims. Preliminary experimental results showing its dependence on age, gender and health conditions  

CERN Multimedia

Although HRV (Heart Rate Variability) analyses have been carried out for several decades, several limiting factors still make these analyses useless from a clinical point of view. The present paper aims at overcoming some of these limits by introducing the "Life Potential" (BMP), a new mathematical algorithm which seems to exhibit surprising cognitive and predictive capabilities. BMP is defined as a linear combination of five HRV Non-Linear Variables, in turn derived from the thermodynamic formalism of chaotic dynamic systems. The paper presents experimental measurements of BMP (Average Values and Standard Deviations) derived from 1048 Holter tests, matched in age and gender, including a control group of 356 healthy subjects. The main results are: (a) BMP always decreases when the age increases, and its dependence on age and gender is well established; (b) the shape of the age dependence within "healthy people" is different from that found in the general group: this behavior provides evidence of possible illn...

Barra, Orazio A

2013-01-01

51

Tagging-SNP haplotype analysis of the secretory PLA2IIa gene PLA2G2A shows strong association with serum levels of sPLA2IIa: results from the UDACS study.  

Science.gov (United States)

Recent prospective analysis identified secretory phospholipase A(2)-IIa (sPLA(2)IIa) as a coronary artery disease (CAD) risk predictor. This study aimed to examine the relationship between serum levels of sPLA(2)IIa and variation in the sPLA(2)IIa gene (PLA2G2A) in a cohort of patients with Type II diabetes (T2D) mellitus. Six tagging single nucleotide polymorphisms (tSNPs) accounting for > 92% of the genetic variability in PLA2G2A were identified and distinguished six common haplotypes (frequencies > 5%). In the 523 Caucasian T2D patients, levels of sPLA(2)IIa, independent of CRP, were negatively correlated with total antioxidant status (P = 0.003) and high-density lipoprotein cholesterol (P = 0.006) in men and correlated with CAD status in women (P = 0.002) (Odds ratio of top two tertiles versus bottom = 2.50) [95% CI (1.13-5.53) P = 0.024]. Overall, tSNP haplotypes showed a highly significant association with sPLA(2)IIa levels (P < 0.0001), explaining 6.3% of the variance. The most common haplotype (frequency 14.2%) was associated with 53% higher sPLA(2)IIa levels [3.25 ng/ml (+/- 0.14)] compared with the combined other haplotypes [2.13 ng/ml (+/- 0.09), P < 0.00001]. Five of the six tSNPs were associated with significant effects on sPLA(2)IIa levels but the raising haplotype could not be distinguished by a single tSNP and none are likely to be functional. These data confirm the relationship between elevated sPLA(2)IIa levels and CAD risk reported in both cases: control and prospective analyses. The strong impact of PLA2G2A haplotypic variation on sPLA(2)IIa levels will help clarify the causality of this association. PMID:16368710

Wootton, Peter T E; Drenos, Fotios; Cooper, Jackie A; Thompson, Simon R; Stephens, Jeffrey W; Hurt-Camejo, Eva; Wiklund, Olov; Humphries, Steve E; Talmud, Philippa J

2005-12-20

52

Tagging-SNP haplotype analysis of the secretory PLA2IIa gene PLA2G2A shows strong association with serum levels of sPLA2IIa: results from the UDACS study.  

UK PubMed Central (United Kingdom)

Recent prospective analysis identified secretory phospholipase A(2)-IIa (sPLA(2)IIa) as a coronary artery disease (CAD) risk predictor. This study aimed to examine the relationship between serum levels of sPLA(2)IIa and variation in the sPLA(2)IIa gene (PLA2G2A) in a cohort of patients with Type II diabetes (T2D) mellitus. Six tagging single nucleotide polymorphisms (tSNPs) accounting for > 92% of the genetic variability in PLA2G2A were identified and distinguished six common haplotypes (frequencies > 5%). In the 523 Caucasian T2D patients, levels of sPLA(2)IIa, independent of CRP, were negatively correlated with total antioxidant status (P = 0.003) and high-density lipoprotein cholesterol (P = 0.006) in men and correlated with CAD status in women (P = 0.002) (Odds ratio of top two tertiles versus bottom = 2.50) [95% CI (1.13-5.53) P = 0.024]. Overall, tSNP haplotypes showed a highly significant association with sPLA(2)IIa levels (P < 0.0001), explaining 6.3% of the variance. The most common haplotype (frequency 14.2%) was associated with 53% higher sPLA(2)IIa levels [3.25 ng/ml (+/- 0.14)] compared with the combined other haplotypes [2.13 ng/ml (+/- 0.09), P < 0.00001]. Five of the six tSNPs were associated with significant effects on sPLA(2)IIa levels but the raising haplotype could not be distinguished by a single tSNP and none are likely to be functional. These data confirm the relationship between elevated sPLA(2)IIa levels and CAD risk reported in both cases: control and prospective analyses. The strong impact of PLA2G2A haplotypic variation on sPLA(2)IIa levels will help clarify the causality of this association.

Wootton PT; Drenos F; Cooper JA; Thompson SR; Stephens JW; Hurt-Camejo E; Wiklund O; Humphries SE; Talmud PJ

2006-01-01

53

Alteraciones clínicas, humorales, laparoscópicas e hísticas hepáticas en donantes de sangre con anticuerpo al VHC positivo Clinical, humoral, laparoscopic and hystic hepatic alterations in blood donors showing positive hepatitis virus C antibody test results  

Directory of Open Access Journals (Sweden)

Full Text Available Se realizó un estudio observacional descriptivo de 69 donantes de sangre, con anticuerpos al virus C positivo detectados en el Banco de Sangre Provincial, remitidos a la consulta provincial del Hospital Universitario Provincial "Vladimir Ilich Lenin", entre enero de 2000 a diciembre de 2006, y a quienes se le realizó biopsia hepática translaparoscópica. Con el objetivo de estimar las alteraciones clínicas, humorales, laparoscópicas e histopatológicas hepáticas se revisaron las boletas de solicitud de biopsia. Hubo predominio de las hepatitis crónicas con actividad mínima (12; 33,33 %) y ligera (13; 36,1 %). La mayoría de los pacientes estaban asintomáticos (62; 89,9 %, y con transaminasas normales (47; 68,1 %). La laparoscopia constituyó una prueba muy específica, con un 84,4 % de especificidad, con un considerable valor de una prueba positiva, 75 %, para el diagnóstico de la hepatitis crónica. Sin embargo, las bajas cifras de la sensibilidad (41 %) y del valor predictivo de una prueba negativa (57,1 %) para el diagnóstico de la hepatitis crónica, reafirman que la biopsia hepática sigue siendo la prueba de oro para el diagnóstico de esta enfermedad.An observational and descriptive study was made on 69 blood donors, who had positive C virus antibodies detected by the provincial blood bank and had been referred to "Vladimir Ilich Lenin" provincial university hospital from January 2000 to December 2006. They were performed translaparoscopic hepatic biopsy. For the purpose of estimating clinical, humoral, laparoscopic and histopathological hepatic disorders, the biopsy request forms were checked. Chronic hepatitis predominated, with minimal activity (12; 33.335) and slight activity (13; 36.1 %). Most of patients were asymptomatic (62; 89.9 %) and their transaminase values were normal (47; 68.1 %). Laparoscopy was a very specific test showing 84.4 % specificity, with a high value (75 %) in a positive test for chronic hepatitis diagnosis. However, low figures of sensitivity (41 %) and of the predictive value in a negative test (57.1 %) for chronic hepatitis diagnosis reaffirmed that hepatic biopsy continues to be the golden test for the diagnosis of this disease.

Agustín Mulet Pérez; Évora Arencibia Vidal; Martha Gámez Escalona; Menelio Pullés Labadié; Marlen Pérez Lorenzo; Agustín Mulet Gámez

2009-01-01

54

Women show worse control of type 2 diabetes and cardiovascular disease risk factors than men: results from the MIND.IT Study Group of the Italian Society of Diabetology.  

UK PubMed Central (United Kingdom)

BACKGROUND AND AIMS: The study explores the degree of control of hyperglycaemia and cardiovascular (CV) disease risk factors in men and women with type 2 diabetes and the impact thereon of obesity, central adiposity, age and use of medications. METHODS AND RESULTS: A cross-sectional survey was conducted at 10 hospital-based outpatients diabetes clinics. 1297 men and 1168 women with no previous CV events were studied. Women were slightly (only one year) older and more obese than men: average BMI was respectively 30.7 ± 5.7 vs 28.6 ± 4.1 kg/m(2) (p < 0.001), and prevalence of abdominal obesity was 86% vs 44% (p < 0.001). Women smoked less, but had higher HbA1c, LDL cholesterol, non-HDL cholesterol, systolic blood pressure and serum fibrinogen than men. Accordingly optimal targets for HbA1c (<7%), LDL cholesterol (<100 mg/dL), HDL cholesterol (>40 for men, >50 for women, mg/dL), and systolic blood pressure (<130 mmHg) were less frequently achieved by women than men (respectively 33.8% vs 40.2%; 14.6% vs 19.2%; 34.1% vs 44.5%; 68.8% vs 72%; p < 0.05 for all). Findings were confirmed after stratification for waist circumference (< or ? 88 cm for women; < or ? 102 cm for men), BMI (< or ? 25 kg/m(2)) or age (< or ? 65 years). As for treatment, women were more likely than men to take insulin, alone or in combination with oral hypoglycaemic drugs, to be under anti-hypertensive treatment, whereas the use of lipid lowering drugs was similar in men and women. CONCLUSIONS: Control of hyperglycaemia and major CVD risk factors is less satisfactory in women than men. The gender disparities are not fully explained by the higher prevalence of total and central obesity in women; or by a less intensive medical management in women.

Franzini L; Ardigò D; Cavalot F; Miccoli R; Rivellese AA; Trovati M; Zavaroni I; Vaccaro O

2013-03-01

55

Study shows disappointing results in many safety indicators.  

UK PubMed Central (United Kingdom)

Improved monitoring is key to preventing hospital-acquired conditions. Getting patients ambulatory as soon as possible can help prevent bed sores. Allowing families to call rapid response teams helped reduce incidents of respiratory failure.

2009-06-01

56

Applications of surveillance programme results to reactor pressure vessel integrity assessment. Results of a coordinated research project 2000-2004  

International Nuclear Information System (INIS)

[en] This TECDOC has been developed under an IAEA Coordinated Research Project (CRP) on Surveillance Programme Results Application to Reactor Pressure Vessel Integrity Assessment. This CRP is the fifth in a series that have led to the defining of the most appropriate fracture toughness parameters (using relatively small test specimens) for ensuring structural integrity of reactor pressure vessel (RPV) materials. The CRP group consisted of 20 testing laboratories representing 15 Member States. The CRP had three main objectives: (1) to develop a large database of fracture toughness data using the Master Curve methodology for both precracked Charpy-sized specimens and one-inch thick (25.4 mm) compact tension (1T-CT) specimens, (2) to assess possible specimen bias effects and any effects of the range of temperatures used to determine T0, either using the single temperature or multi-temperature assessment methods, and (3) to develop international guidelines for measuring and applying Master Curve fracture toughness results for RPV integrity assessment. Fracture toughness test results showed clear evidence that lower values of unirradiated T0 were obtained using precracked Charpy specimens compared with results obtained from 1T-CT specimens. This bias in test results is very important when considering the use of precracked Charpy specimens for evaluating RPV integrity. In fact, this is a technical area where the results from this CRP were influential in changing the ASTM test method to include consideration of this effect. The direct measurement approach using the Master Curve approach for RPV structural integrity assessment has distinct advantages over the indirect methods used in the past for assessing radiation embrittlement effects. The Master Curve methodology already has been or is being assimilated into the ASME Boiler and Pressure Vessel Code, ASTM Standards, USNRC Regulations, German Regulations (KTA 3203), IAEA pressurized thermal shock guidelines for WWER reactors as well as the unified procedure for WWER component lifetime assessment and other industry guidance documents governing RPV integrity analysis. This report was written to allow nuclear utility engineers and industry scientists to directly measure fracture toughness using small surveillance size specimens of irradiated reactor pressure vessel steels and directly apply the results using the Master Curve approach for RPV structural integrity assessment. This report provides a summary of Master Curve fracture toughness test results on small surveillance type specimens of the IAEA Reference Material JRQ and other national steels from numerous laboratories throughout the world. In addition to transition temperature testing using Charpy V-notch test specimens, some emphasis was placed on using tensile and early-design fracture toughness test specimens applying elastic-plastic fracture mechanics methods. Further progress in the application of fracture mechanics analysis methods for radiation damage assessment was achieved in this phase. Improvement and unification of neutron dosimetry methods provided better data with less inherent scatter. All results together with their analyses and raw data were summarized in IAEA Technical Reports Series No. 265

2005-01-01

57

Evaluation of the threshold values for fatigue crack propagation starting at the V-notch.  

Czech Academy of Sciences Publication Activity Database

. Žilina : MC Energy, 2000 - (Kompiš, V.; Žmindák, M.; Maunder, E.), s. 014[International conference, Numerical methods in continuum mechanics /8./. Liptovský Ján (SK), 19.09.2000-24.09.2000]Grant CEP: GA AV ?R KSK1076602; GA AV ?R IBS2041001Kód oboru RIV: JL - Únava materiálu a lomová mechanika

Klusák, JanG; Knésl, Zden?k

58

Reality shows: uma abordagem psicossocial/ Reality shows: a psychosocial approach  

Scientific Electronic Library Online (English)

Full Text Available Abstract in portuguese Desde os primórdios da civilização, o ser humano mostra necessidade de representar cenicamente seus dramas pessoais e vicissitudes existenciais. O "reality show" é uma das versões pós-modernas da encenação da vida humana. Este artigo, por meio de uma pesquisa bibliográfica, analisa criticamente as relações existentes entre o "reality show" e aspectos psicossociais do comportamento humano. Conclui-se que tais programas televisivos são o retrato da contemporanei (more) dade, ou seja, revelam a morte do sujeito, a fugacidade das experiências vividas, a desvalorização da história e o culto à imagem e à superficialidade. Por meio da sedução do espectador, mobilizam-se aspectos primitivos de seu psiquismo, fazendo com que ele se sinta narcisicamente poderoso e onipotente e se acredite dono do destino dos participantes do programa. Sugerem-se novos estudos que contribuam para a reflexão crítica e maior conscientização. Abstract in english As from the earliest period of civilization, human beings have shown their need to perform their personal dramas and existential vicissitudes on stage. The reality show is one of the postmodern versions of human life staging. Based on a bibliographical research, this article analyzes on a critical basis the relations between the reality show and psychosocial aspects of human behavior. Such TV programs portray contemporaneous life, that is, they disclose the subject's deat (more) h, the fugacity of life experiences, the history devaluation and the cult of image and superficiality. By seducing the spectator, the reality show mobilizes primitive aspects of the spectator's psychism, thereby making him feel narcissistically powerful and omnipotent, and able to decide the participants' fate. New studies that contribute to critical considerations and deeper consciousness would be advisable.

Millan, Marília Pereira Bueno

2006-06-01

59

Reality shows: uma abordagem psicossocial Reality shows: a psychosocial approach  

Directory of Open Access Journals (Sweden)

Full Text Available Desde os primórdios da civilização, o ser humano mostra necessidade de representar cenicamente seus dramas pessoais e vicissitudes existenciais. O "reality show" é uma das versões pós-modernas da encenação da vida humana. Este artigo, por meio de uma pesquisa bibliográfica, analisa criticamente as relações existentes entre o "reality show" e aspectos psicossociais do comportamento humano. Conclui-se que tais programas televisivos são o retrato da contemporaneidade, ou seja, revelam a morte do sujeito, a fugacidade das experiências vividas, a desvalorização da história e o culto à imagem e à superficialidade. Por meio da sedução do espectador, mobilizam-se aspectos primitivos de seu psiquismo, fazendo com que ele se sinta narcisicamente poderoso e onipotente e se acredite dono do destino dos participantes do programa. Sugerem-se novos estudos que contribuam para a reflexão crítica e maior conscientização.As from the earliest period of civilization, human beings have shown their need to perform their personal dramas and existential vicissitudes on stage. The reality show is one of the postmodern versions of human life staging. Based on a bibliographical research, this article analyzes on a critical basis the relations between the reality show and psychosocial aspects of human behavior. Such TV programs portray contemporaneous life, that is, they disclose the subject's death, the fugacity of life experiences, the history devaluation and the cult of image and superficiality. By seducing the spectator, the reality show mobilizes primitive aspects of the spectator's psychism, thereby making him feel narcissistically powerful and omnipotent, and able to decide the participants' fate. New studies that contribute to critical considerations and deeper consciousness would be advisable.

Marília Pereira Bueno Millan

2006-01-01

60

Coreopsis plant named Show Stopper  

UK PubMed Central (United Kingdom)

A new and distinct Coreopsis plant named 'Show Stopper' characterized by prolific bloom of red purple daisy-type inflorescences, each about 5 cm wide, with excellent perennial survival, and a large mounding plant.

KORLIPARA HARINI

 
 
 
 
61

Tokyo Motor Show 2003; Tokyo Motor Show 2003  

Energy Technology Data Exchange (ETDEWEB)

The text which follows present the different techniques exposed during the 37. Tokyo Motor Show. The report points out the great tendencies of developments of the Japanese automobile industry. The hybrid electric-powered vehicles or those equipped with fuel cells have been highlighted by the Japanese manufacturers which allow considerable budgets in the research of less polluting vehicles. The exposed models, although being all different according to the manufacturer, use always a hybrid system: fuel cell/battery. The manufacturers have stressed too on the intelligent systems for navigation and safety as well as on the design and comfort. (O.M.)

Joly, E.

2004-01-01

62

Phyllodes tumor showing intraductal growth.  

UK PubMed Central (United Kingdom)

Phyllodes tumor of the breast is a rare fibroepithelial lesion and particularly uncommon in adolescent girls. It is thought to arise from the periductal rather than intralobular stroma. Usually, it is seen as a well-defined mass. Phyllodes tumor showing intraductal growth is extremely rare. Here we report a girl who has a phyllodes tumor with intraductal growth.

Makidono A; Tsunoda H; Mori M; Yagata H; Onoda Y; Kikuchi M; Nozaki T; Saida Y; Nakamura S; Suzuki K

2013-07-01

63

ENVITEC shows off air technologies  

Energy Technology Data Exchange (ETDEWEB)

The ENVITEC International Trade Fair for Environmental Protection and Waste Management Technologies, held in June in Duesseldorf, Germany, is the largest air pollution exhibition in the world and may be the largest environmental technology show overall. Visitors saw thousands of environmental solutions from 1,318 companies representing 29 countries and occupying roughly 43,000 square meters of exhibit space. Many innovations were displayed under the category, ``thermal treatment of air pollutants.`` New technologies include the following: regenerative thermal oxidizers; wet systems for removing pollutants; biological scrubbers;electrostatic precipitators; selective adsorption systems; activated-coke adsorbers; optimization of scrubber systems; and air pollution monitors.

McIlvaine, R.W.

1995-08-01

64

Casimir experiments showing saturation effects  

CERN Multimedia

We address several different Casimir experiments where theory and experiment disagree. First out is the classical Casimir force measurement between two metal half spaces; here both in the form of the torsion pendulum experiment by Lamoreaux and in the form of the Casimir pressure measurement between a gold sphere and a gold plate as performed by Decca et al.; theory predicts a large negative thermal correction, absent in the high precision experiments. The third experiment is the measurement of the Casimir force between a metal plate and a laser irradiated semiconductor membrane as performed by Chen et al.; the change in force with laser intensity is larger than predicted by theory. The fourth experiment is the measurement of the Casimir force between an atom and a wall in the form of the measurement by Obrecht et al. of the change in oscillation frequency of a 87 Rb Bose-Einstein condensate trapped to a fused silica wall; the change is smaller than predicted by theory. We show that saturation effects can exp...

Sernelius, Bo E

2009-01-01

65

Biomass route shows lower cost  

Energy Technology Data Exchange (ETDEWEB)

There has been much discussion concerning the economics of using biomass for the production of substitute fuels and it has been argued that the net energy gain could be small or even negative. The development of the ATPAL process is described and it is claimed that only one quarter of the energy equivalent contained in the alcohol will be consumed in the total process. Both the pilot plant and a commercial scale plant with some modifications are described. The most significant advantage claimed for the ATPAL process is in its low process energy savings resulting from mechanical vapour recompression, recycling the heat and production of a low volume of effluent.

Taffe, P.

1980-11-21

66

Results of examinations of pressure vessel samples and instrument nozzles from the TMI-2 lower head  

Energy Technology Data Exchange (ETDEWEB)

Fifteen prism-shaped steel samples were removed from the lower head of the damaged TMI-2 reactor pressure vessel to assess the effects of approximately 19 metric tons of molten core debris that had relocated there during the 1979 loss-of-coolant accident. Metallographic examinations of the samples revealed that inside surface temperatures of 800 to 1,100{degree}C were attained during the accident in an elliptical shaped ``hot spot`` {approx}1 {times} 0.7 m. Tensile, creep, and Charpy V-notch specimens were also cut from the samples to assess the mechanical properties of the lower head material at temperatures up to the peak accident temperature. These properties were used in a margin to failure analysis of the lower head. Examinations of instrument nozzles removed from the lower head region assisted in defining the relocation scenario of the molten core debris and showed that the lower head was largely protected from catastrophic failure by a solidified layer around the molten core debris that acted as a partial thermal insulator.

Korth, G.E. [EG and G Idaho, Inc., Idaho Falls, ID (United States); Diercks, D.R.; Neimark, L.A. [Argonne National Lab., IL (United States)

1993-10-01

67

Pancreatic tumors show high levels of hypoxia  

International Nuclear Information System (INIS)

Purpose: Because of the dismal outcomes of conventional therapies for pancreatic carcinomas, we postulated that hypoxia may exist within these tumors. Methods and Materials: Seven sequential patients with adenocarcinomas of the pancreas consented to intraoperative measurements of tumor oxygenation using the Eppendorf (Hamburg, Germany) polargraphic electrode. Results: All 7 tumors demonstrated significant tumor hypoxia. In contrast, adjacent normal pancreas showed normal oxygenation. Conclusion: Tumor hypoxia exists within pancreatic cancers.

2000-11-01

68

Lemurs and macaques show similar numerical sensitivity.  

UK PubMed Central (United Kingdom)

We investigated the precision of the approximate number system (ANS) in three lemur species (Lemur catta, Eulemur mongoz, and Eulemur macaco flavifrons), one Old World monkey species (Macaca mulatta) and humans (Homo sapiens). In Experiment 1, four individuals of each nonhuman primate species were trained to select the numerically larger of two visual arrays on a touchscreen. We estimated numerical acuity by modeling Weber fractions (w) and found quantitatively equivalent performance among all four nonhuman primate species. In Experiment 2, we tested adult humans in a similar procedure, and they outperformed the four nonhuman species but showed qualitatively similar performance. These results indicate that the ANS is conserved over the primate order.

Jones SM; Pearson J; Dewind NK; Paulsen D; Tenekedjieva AM; Brannon EM

2013-09-01

69

Pectin shows antibacterial activity against Helicobacter pylori  

Directory of Open Access Journals (Sweden)

Full Text Available Pectins are the collective name for a group of heterogeneous, high molecular weight, branched polysaccharides that are found in the cell walls of higher plants. In this study, we intend to determine the antibacterial activity of pectin against reference strains and clinical isolates of Helicobacter pylori. The results show that pectin produced antibacterial effects on all the 16 clinical isolates and 2 reference strains of H. pylori with the greatest antibacterial effect at a low pH (5.0) versus higher pHs. The lowest Minimum Inhibitory Concentration recorded was of 0.016 ?g/?l. Antibiotic resistance, therapy costs, and undesirable side effects stress the need for new antimicrobials or alternative therapies. The results from our study can further our goal of future eradication of H. pylori infection using new molecules.

Ziad Daoud; Mihir Sura; Roula M. Abdel-Massih

2013-01-01

70

Resultados histológicos e detecção do HPV em mulheres com células escamosas atípicas de significado indeterminado e lesão escamosa intra-epitelial de baixo grau na colpocitologia oncológica/ Histological results and HPV detection in women with pap smear showing atypical squamous cells of undetermined significance and low-grade squamous intraepithelial lesion  

Scientific Electronic Library Online (English)

Full Text Available Abstract in portuguese OBJETIVOS: avaliar o desempenho da colpocitologia oncológica (CO) e da Captura de Híbridos II (CHII) para o diagnóstico de lesão cervical histológica significativa (NIC2/3) em mulheres encaminhadas com CO contendo atipias celulares de significado indeterminado (ASCUS) ou lesão escamosa intra-epitelial de baixo grau (LSIL). MÉTODOS: estudo de corte transversal no qual foram incluídas 161 mulheres encaminhadas, entre agosto de 2000 e setembro de 2002, devido a CO co (more) m resultado de ASCUS ou LSIL. As mulheres responderam a questionário específico sobre características sociodemográficas e reprodutivas e foram submetidas a exame ginecológico com coleta de CO e CHII, sendo realizada colposcopia com eventual biópsia de áreas suspeitas. Foi aplicado o teste do qui-quadrado para as associações da idade, uso de condom, uso de anticoncepcional oral e tabagismo com os resultados da CHII. Foram calculados a sensibilidade, especificidade, valor preditivo positivo e valor preditivo negativo da CO e da CHII para detectar NIC2/3. Todos os cálculos foram realizados com intervalos de confiança estatística de 95%. RESULTADOS: sessenta e sete porcento das mulheres com menos de 30 anos de idade tiveram testes positivos para o HPV. A CO e CHII tiveram sensibilidade de 82% em detectar NIC2/3 quando considerados como positivos ASCUS, LSIL ou HSIL. Quando se consideram como positivas apenas as CO com HSIL, este exame apresenta acentuado ganho de especificidade (de 29 para 95%) e valor preditivo positivo (de 12 para 50%), superando a CHII, porém com redução igualmente significativa de sua sensibilidade (de 82 para 41%). CONCLUSÕES: nossos resultados indicaram grande potencial da CHII para detectar mulheres com NIC2/3 entre as pacientes com ASCUS/LSIL na CO de encaminhamento. Abstract in english OBJECTIVE: to assess the ability of Pap smear and hybrid capture II (HCII) to detect clinically significant cervical lesions (CIN2/3) in women referred to hospital due to atypical squamous cells of unknown significance (ASCUS) or low-grade squamous intraepithelial lesions (LSIL). METHODS: a cross-sectional study comprising 161 women referred to the Taubaté University Hospital due to ASCUS/LSIL, between August 2000 and September 2002. All women responded to a questionnair (more) e regarding sociodemographic and reproductive characteristics and were subjected to gynecological examination with specimen collection for Pap test and HCII, along with colposcopy and eventual cervical biopsy. The relationship between HCII results and age, use of condom, oral hormonal contraception, and smoking were evaluated by the chi-square test. The sensitivity, specificity, positive and negative predictive values of both Pap test and HCII were calculated. All calculations were performed within 95% confidence intervals. RESULTS: sixty-seven percent of the women that tested positive for HPV were less than 30 years old. Pap smear and HCII showed the same 82% sensitivity in detecting CIN2/3 when the threshold for a positive Pap result was ASCUS, LSIL or HSIL. Pap smear specificity and positive predictive values were substantially increased when only HSIL results were considered as positive (from 29 to 95% and 12 to 50%, respectively). These figures were superior to those of HCII, but at the expense of an expressive loss of sensitivity (from 82% to 41%). CONCLUSIONS: our results substantiate the potential of HCII in detecting CIN2/3 among women referred due to ASCUS/LSIL.

Santos, André Luis Ferreira; Derchain, Sophie Françoise Mauricette; Sarian, Luis Otávio; Campos, Elizabete Aparecida; Santos, Marcos Roberto dos; Fonsechi-Carvasan, Gislaine Aparecida

2004-07-01

71

Do infants show a cortisol awakening response?  

UK PubMed Central (United Kingdom)

Upon awakening from sleep, combined processes of deactivation of the hippocampus and activation of suprachiasmatic nucleus result in a marked increase in cortisol release from structures within the hypothalamic-pituitary-adrenal axis. This phenomenon, termed the cortisol awakening response (CAR), has been studied extensively in adults. In the current study, we examine this phenomenon for the first time in infancy. Saliva samples were collected by 32 mothers from themselves and their infants (13 males; 7.8-17.4 months of age) at the infant's AM waking (and 30?min later), and upon waking from the infant's first nap (and 30?min later). In contrast to what has been observed with the CAR in adults, cortisol levels declined from AM waking to 30?min post-waking. Moreover, cortisol levels did not significantly rise or fall following naps. Consistent with prior research, both group-level and dyadic-level analyses showed that cortisol levels for mother-infant dyads were associated.

Bright MA; Granger DA; Frick JE

2012-11-01

72

Influence of the sinngularity induced by the free surface on behaviour of thin body with a v-notch.  

Czech Academy of Sciences Publication Activity Database

. Ostrava : VŠB - Technická univerzita Ostrava, 2007, s. 1-8. ISBN 978-80-248-1389-9.[International Scientific Conference Applied Mechanics 2007 /9./. Malenovice (CZ), 16.04.2007-19.04.2007]Grant CEP: GA ?R GD106/05/H008; GA ?R GA101/05/0227Výzkumný zám?r: CEZ:AV0Z20410507Klí?ová slova: Surface singularityKód oboru RIV: JL - Únava materiálu a lomová mechanika

Majer, Zden?kG; Huta?, Pavel; Náhlík, Luboš

73

PREPARATION SHOWING BACTERICIDAL AND ANTIMETASTATIC ACTIVITY  

UK PubMed Central (United Kingdom)

FIELD: medicine, pharmaceutics. ^ SUBSTANCE: preparation shows high bactericidal and antimetastatic activity that is ensured by the presence of a water extract of shelf fungus and birch bark taken in weight proportions 1:4. ^ EFFECT: preparation shows bactericidal and antimetastatic activity. ^ 3 tbl

IVLIEV IGOR ALEKSEEVICH; POLETAEV ALEKSEJ PETROVICH; GRIBANOV ALEKSANDR PAVLOVICH; BYKOV ANATOLIJ VLADIMIROVICH; OVCHINNIKOVA ELENA GENNAD EVNA

74

Small punch test evaluation of intergranular embrittlement of an alloy steel  

International Nuclear Information System (INIS)

[en] The ductile-brittle transition temperature in steel is commonly determined using Charpy V-notch impact specimens as specified by ASTM E23-81. In some specific cases, however, the use of this standardized test specimen may be impractical, if not impossible. For instance, it is well known that ferritic steels show a substantial degradation of the mechanical properties after long time exposure to an irradiation environment. Because of the increase in strength and the reduction in ductility due to neutron irradiation, the Charpy V-notch transition temperature is raised causing concern from a safety point of view. To study these radiation effects, a test specimen much smaller than the standard Charpy V-notch specimen would be extremely desirable for two reasons. First, to study neutron damage small specimens take less space within a reactor. Secondly, the damage achieved in simulation experiments, such as proton or electron accelerators, is limited to small penetration depths. Several efforts on the development of such a small test specimen, similar to that used to determine the ductility of sheet metal, as recommended by ASTM E643-78, have been described in the literature. The paper reports on correlations between small punch (SP) and Charpy V-notch (CVN) test results obtained on temper-embrittled NiCr steel. The ductile-brittle transition temperature (DBTT) with intergranular embrittlement being induced by grain boundary segregation of specific impurities was determined. The relation between test results discussed in terms of the micromechanisms of intergranular cracking. It is suggested that in radiation embrittlement investigations similar correlations may be obtained

1983-01-01

75

Gene Therapy for Advanced Parkinson's Shows Promise  

Science.gov (United States)

... resources & more. Order Free Materials Today Science News Gene Therapy for Advanced Parkinson’s Shows Promise - Mar 23 ... Parkinson’s disease (PD) – which involves inserting the human gene known as GAD deep into a brain structure – ...

76

Study shows cattle defects linked to flares  

Energy Technology Data Exchange (ETDEWEB)

Landowners regularly confront oil and gas company operators with complaints that exposure to gas flares is causing health problems to both their families and their cattle. While scientific data on the effects of solution gas flaring on human health are lacking, the issue is of growing concern to oil and gas companies. Dr. Cheryl Waldner of the University of Saskatchewan's Western College of Veterinary Medicine has conducted a study on the effects of exposure to flare gas emissions on cattle in western Canada. Participants at a recent conference in Calgary dealing with new provincial flaring rules were told that her study revealed definitive results linking exposure to gas flares with an increased risk of stillbirth in cattle. The findings were based on studies conducted between 1992 and 1996. The study consistently showed that cows exposed to emissions from well sites have a greater risk of giving birth to still-born calves. There has not been much progress on the side of human health because more information is needed about the important indicators about the complex mix of chemicals and the sensitivity to them by humans. However, scientists are confident that there is no poisoning pandemic due to flaring. Cattle are easy to study and are very efficient at sampling their environment. Research has shown that there is more evidence of harm from exposure to flare gas than expected. Thus far, the courts have mandated few monetary awards. However, in the case of Jones vs. Mobil Oil Canada, the plaintiff won due to meticulous record keeping of the weight, age and health of each cow in 2 separate herds. These records provided evidence that the cows exposed to leaked hydrocarbons had suffered adverse health effects. The plaintiff was awarded compensation of approximately $400,000. The Western Interprovincial Scientific Studies Association has recently launched a $16 million project to study the effects of particulate matter on 30,000 cows in 200 herds across Canada. This initiative will give scientists an even better understanding of the health effects of exposure to flaring on cattle.

Lorenz, A.

2001-10-01

77

2008 LHC Open Days Physics: the show  

CERN Multimedia

A host of events and activities await visitors to the LHC Open Days on 5 and 6 April. A highlight will be the physics shows funded by the European Physical Society (EPS), which are set to surprise and challenge children and adults alike! School children use their experience of riding a bicycle to understand how planets move around the sun (Copyright : Circus Naturally) Participating in the Circus Naturally show could leave a strange taste in your mouth! (Copyright : Circus Naturally) The Rino Foundation’s experiments with liquid nitrogen can be pretty exciting! (Copyright: The Rino Foundation)What does a bicycle have in common with the solar system? Have you ever tried to weigh air or visualise sound? Ever heard of a vacuum bazooka? If you want to discover the answers to these questions and more then come to the Physics Shows taking place at the CERN O...

2008-01-01

78

Examples show system-performance upgrade  

Energy Technology Data Exchange (ETDEWEB)

Described are ways of improving the productivity of the turboexpander refrigeration system's expander and compressor through systematic review of component performance. Improvements in cycle efficiency can best be implemented through a combined effort of those responsible for the operation of the gas processing plant and design engineers familiar with performance of specialized components. Manufacturers of turbomachinery should be able to recommend specific changes to improve performance and to quantify the net benefits these changes have on overall plant efficiency. Presented are graphs showing effect of heat exchanger fouling, performance loss and cost of lost performance. Shows how, by modifying the compressor wheel, expander nozzle, and repositioning compressor diffusers, the expander (with modified nozzles) was able to pass the higher flow, and compressor efficiency showed an increase of 10% at the increased flow rate. Redesigning new aerodynamic components was not necessary since existing hardware was modified to new conditions at a cost saving.

McIntire, R.

1982-07-12

79

Development, management and economy of show caves.  

Directory of Open Access Journals (Sweden)

Full Text Available The problems concerning the development of show caves are here considered by taking into account different aspects of the problem. A procedure to carry out an Environmental Impact Assessment (EIA) has been established in the last decade and it is now currently applied. Such an assessment starts with a pre-operational phase to obtain sufficient information on the undisturbed status of a cave to be developed into a show cave. Successively a programme for its development is established with the scope to optimise the intervention on the cave at the condition that its basic environmental parameters are not irreversibly modified. The last phase of the assessment is focussed to assure a feedback through a monitoring network in order to detect any unforeseen difference or anomaly between the project and the effective situation achieved after the cave development. Some data on some of the most important show caves in the world are reported and a tentative evaluation of the economy in connection with the show caves business is eventually made.

Cigna Arrigo A.; Burri Ezio

2000-01-01

80

A Talk Show from the Past.  

Science.gov (United States)

|Describes a two-day activity in which elementary students examine voting rights, the right to assemble, and women's suffrage. Explains the game, "Assemble, Reassemble," and a student-produced talk show with five students playing the roles of leaders of the women's suffrage movement. Profiles Elizabeth Cady Stanton, Lucretia Mott, Susan B.…

Gallagher, Arlene F.

1991-01-01

 
 
 
 
81

Interaction Management in Nigerian Television Talk Shows  

Directory of Open Access Journals (Sweden)

Full Text Available Although there is a growing number of works on discourse analysis in Nigeria which covers classroom interactions, courtroom discourse, medical communication and media discourse, the language of television (TV) talk shows has not been fully explored. This study therefore, examined turn management in this genre. It identified the turn distribution strategies in Nigerian television talk shows and the contributions of these strategies to the management of the talks. Sacks, Schegloff and Jefferson’s Conversation Analysis served as our theoretical framework. Three Nigerian TV talk shows, namely, “Patito’s Gang”, “New Dawn with Funmi Iyanda” and “Inside Out” were selected for this study. Each selected talk show comprised four sampled episodes. “Patito’s Gang” from a private television station; “New Dawn with Funmi Iyanda” from a national television station and “Inside Out” from a private television station were purposively selected because they were handled by freelance presenters who were free from undue interference. Collection of data spanned four years: 2004-2008. And the analysis was both quantitative and qualitative. Generally, three turn distribution strategies were identified: Current-Speaker-Selects–Next-Speaker, Next-Speaker-Self-Selects-as-Next and Current-Speaker-Continues (where there is no pre-selection or self-selection). Current speaker selected next speaker by direct questioning, gaze and gestures. Next speaker self-selected as next through interruptions, overlaps, discourse markers, pauses and falling intonation. Where there was no pre-selection or self-selection at Transition Relevance Places, the current speaker continued after a pause of about half a second or more. These strategies enabled effective interaction management amongst the participants as turn allocation was not restricted but moderated by the hosts.

Albert Lekan Oyeleye; Omolara Grace Olutayo

2012-01-01

82

Primary cutaneous sarcomas showing rhabdomyoblastic differentiation.  

UK PubMed Central (United Kingdom)

Rhabdomyosarcoma is a rare soft tissue neoplasm most commonly encountered in childhood and adolescence which has a predilection for the head and neck area, the genito-urinary tract and the extremities. Primary cutaneous presentation is extremely unusual and has been rarely reported in the literature. Herein, we describe two cases of rhabdomyosarcoma arising in the dermis of a 9-year-old girl and an 86-year-old man. Clinically, the tumours presented as solitary plaque-like or nodular lesions confined to the skin of the nose and chest wall, respectively. Histologically, the tumour in the first patient corresponded to an embryonal rhabdomyosarcoma. The tumour recurred locally four times, and in the last recurrence, showed features resembling those of malignant 'triton' tumour with fascicles of S-100 protein-positive spindle cells admixed with the rhabdomyoblastic components. The tumour in the second patient corresponded to the solid variant of alveolar rhabdomyosarcoma. Immunohistochemical studies in both tumours showed positive labelling for muscle-specific actin, desmin and vimentin. Ultrastructural examination in one case showed clusters of intermediate filaments in the cytoplasm recapitulating abortive sarcomeric structures consistent with rhabdomyoblastic differentiation. Both patients developed repeated recurrences over a period of 2-4 years despite adequate surgical excision, and the second patient had an axillary lymph node metastasis. Primary cutaneous rhabdomyosarcoma should be considered in the evaluation of small 'blue cell' tumours or undifferentiated malignant neoplasms of the skin, and appropriate immunohistochemical studies in conjunction with electron microscopy should be employed for proper evaluation of such lesions.

Wong TY; Suster S

1995-01-01

83

Trials show delayed recurrence in ovarian cancer.  

UK PubMed Central (United Kingdom)

Phase I trials of 2 treatments for recurrent ovarian cancer-a 2-step immunotherapy treatment and an antibody-drug conjugate-demonstrated promising early results in delaying recurrence, in work presented at the American Association for Cancer Research Annual Meeting 2013.

Bender E

2013-06-01

84

Gasolines show varied responses to alcohols  

Energy Technology Data Exchange (ETDEWEB)

The current situation regarding alcohol additives and gasoline is presented. This is followed by a discussion of some specific results of research on the gasoline blending characteristics of alcohols, particularly those of the gasoline additive Oxinol. This work permits the comparison of their economic values relative to other octane enhancers, including refining processing options. (Refs. 4).

DeJovine, J.M.; Guetens, E.G. Jr.; Yogis, G.J.; Davis, B.C.; Douthit, W.H.; Hagstrom, P.E.

1983-02-14

85

Surveys show support for green 'activities'.  

UK PubMed Central (United Kingdom)

Two independently conducted surveys on sustainability - one into the 'views and values' of NHS 'leaders', and the other questioning the public about the importance of the 'green agenda' in the NHS, and their opinions on how the service might most effectively reduce its carbon footprint, form the basis of Sustainability in the NHS: Health Check 2012, a new NHS Sustainable Development Unit (NHS SDU) publication. As HEJ editor Jonathan Baillie reports, the new document also presents updated data on the 'size' of the carbon footprint of the NHS in England, showing that, although good work by a number of Trusts in the past two years has seen healthcare-generated carbon emissions start to 'level off', the biggest contributors have been the current health service spending review, and the increased national availability of renewable energy.

Baillie J

2012-03-01

86

Microbiological and environmental issues in show caves.  

UK PubMed Central (United Kingdom)

Cultural tourism expanded in the last half of the twentieth century, and the interest of visitors has come to include caves containing archaeological remains. Some show caves attracted mass tourism, and economical interests prevailed over conservation, which led to a deterioration of the subterranean environment and the rock art. The presence and the role of microorganisms in caves is a topic that is often ignored in cave management. Knowledge of the colonisation patterns, the dispersion mechanisms, and the effect on human health and, when present, over rock art paintings of these microorganisms is of the utmost importance. In this review the most recent advances in the study of microorganisms in caves are presented, together with the environmental implications of the findings.

Saiz-Jimenez C

2012-07-01

87

Microbiological and environmental issues in show caves.  

Science.gov (United States)

Cultural tourism expanded in the last half of the twentieth century, and the interest of visitors has come to include caves containing archaeological remains. Some show caves attracted mass tourism, and economical interests prevailed over conservation, which led to a deterioration of the subterranean environment and the rock art. The presence and the role of microorganisms in caves is a topic that is often ignored in cave management. Knowledge of the colonisation patterns, the dispersion mechanisms, and the effect on human health and, when present, over rock art paintings of these microorganisms is of the utmost importance. In this review the most recent advances in the study of microorganisms in caves are presented, together with the environmental implications of the findings. PMID:22806150

Saiz-Jimenez, Cesareo

2012-05-11

88

High temperature filter tests show exposure reduction  

Energy Technology Data Exchange (ETDEWEB)

The results of reduction of exposure dose at BWR type reactors of the first and second NPP units in Oxcarshamen by means of high temperature filters of new construction are presented. In new filters instead of wire cuttings changeable cartridges are used. Each filtering cartridge is fixed in a stable vessel with flanges. Two or more cartridges connected in parallel constitute a new high temperature filter. The first test results have shown that the total /sup 60/Co absorption efficiency constitutes approximately 70%, /sup 58/Co is considerably higher, for /sup 54/Mn and /sup 65/Zn it is equal approximately 40%. For several years of NPP operation the application of new filters reduces the dose rate by approximately 35%.

Aivars, R.; Landgren, K.; Elkert, D.; Persson, B.

1981-01-01

89

Well servicing activity shows new life  

Energy Technology Data Exchange (ETDEWEB)

This article reports the results of the 1984 well servicing survey. Operators spent more than $3.5 billion, a 25% increase over the $2.8 billion spent in 1983. The number of lift and tubular repairs last year climbed significantly as well. But increased spending and activity has not meant improved profits. Although demand is up, increased activity has not offset the oversupply of rigs, equipment and manufacturing facilities.

Moore, S.D.

1985-07-01

90

ODSCC algorithm shows correlation with degradation  

International Nuclear Information System (INIS)

[en] Over the last few years we have attempted to develop an algorithm to evaluate the impact of secondary water chemistry on tube degradation in PWR steam generators. Effects of individual factors were assessed and then consolidated to form an algorithm for ODSCC propensity. The algorithm utilizes secondary water chemistry data to calculate ODSCC propensity as a variable named Mega PHI. Prior attempts to correlate algorithm calculations with actual degradation in operating steam generators have resulted in very disappointing results. Recent modifications to the algorithm have demonstrated improved correlation between Mega PHI (calculated result from the algorithm) and actual degradation history from operating plants. The recent modifications involve the inclusion of the synergistic effect of boric acid application of secondary water and of high silica concentration in steam generator toward inhibiting ODSCC. Data from several plants with mill annealed alloy 600 tubing in the steam generators and operating with the primary coolant inlet temperature in the range of 608 to 624 degrees F (320 to 329 degrees C) were evaluated and the results compared with actual degradation reported from in-service inspections. The population of plants includes those with very few tubes repaired and those with hundreds of tubes repaired due to ODSCC at tube support plates. The observation of substantial correlation between the algorithm calculation and actual degradation signifies the roles of boric acid and silica in inhibiting ODSCC. It is recommended that further evaluation of the role of these chemical species be performed using more extensive data. The goal is to modify secondary water chemistry guidelines with the ultimate aim of minimizing corrosion of steam generator tubes. (author)

1998-01-01

91

Verification Survey: NASFAA Survey Shows Administrative Burden Increasing for Financial Aid Offices. Quick Scan Survey Results  

Science.gov (United States)

More than three in four college financial aid offices reported an increase in the number of cases where they must verify information on the Free Application for Federal Student Aid (FAFSA), according to the National Association of Student Financial Aid Administrators' (NASFAA's) latest Quick-Scan Survey. The increase in the number of verification…

National Association of Student Financial Aid Administrators (NJ1), 2009

2009-01-01

92

DITE Langmuir probe results showing probe-size and limiter-shadow effects  

Energy Technology Data Exchange (ETDEWEB)

Experimental evidence is presented for three probe-size effects which influence the interpretation of Langmuir probe measurements in tokamak scrape-off plasmas. Small probes can give erroneously high values of plasma density. Large probes can only measure reliably the average energy of the high energy tail of the electron distribution. Insertion of a large probe into the scrape-off plasma can strongly disturb the plasma necessitating special analysis procedures for recovery of the unperturbed plasma characteristics.

Stangeby, P.C.; McCracken, G.M.; Erents, S.K.; Matthews, G.

1984-04-01

93

Simulation shows hospitals that cooperate on infection control obtain better results than hospitals acting alone.  

UK PubMed Central (United Kingdom)

Efforts to control life-threatening infections, such as with methicillin-resistant Staphylococcus aureus (MRSA), can be complicated when patients are transferred from one hospital to another. Using a detailed computer simulation model of all hospitals in Orange County, California, we explored the effects when combinations of hospitals tested all patients at admission for MRSA and adopted procedures to limit transmission among patients who tested positive. Called "contact isolation," these procedures specify precautions for health care workers interacting with an infected patient, such as wearing gloves and gowns. Our simulation demonstrated that each hospital's decision to test for MRSA and implement contact isolation procedures could affect the MRSA prevalence in all other hospitals. Thus, our study makes the case that further cooperation among hospitals--which is already reflected in a few limited collaborative infection control efforts under way--could help individual hospitals achieve better infection control than they could achieve on their own.

Lee BY; Bartsch SM; Wong KF; Yilmaz SL; Avery TR; Singh A; Song Y; Kim DS; Brown ST; Potter MA; Platt R; Huang SS

2012-10-01

94

Crack-arrest tests on two irradiated high-copper welds. Phase 2: Results of duplex-type experiments  

Energy Technology Data Exchange (ETDEWEB)

The objective of the Heavy-Section Steel Irradiation Program Sixth Irradiation Series is to determine the effect of neutron irradiation on the shift and shape of the lower-bound curve to crack-arrest toughness data. Two submerged-arc welds with copper contents of 0.23 and 0.31 wt % were commercially fabricated in 220-mm-thick plate. Crack-arrest specimens fabricated from these welds were irradiated at a nominal temperature of 288{degrees}C to an average fluence of 1.9 {times} 10{sup 19} neutrons/cm{sup 2} (>1 MeV). This is the second report giving the results of the tests on irradiated duplex-type crack-arrest specimens. A previous report gave results of tests on irradiated weld-embrittled-type specimens. Charpy V-notch (CVN) specimens irradiated in the same capsules as the crack-arrest specimens were also tested, and a 41-J transition temperature shift was determined from these specimens. {open_quotes}Mean{close_quote} curves of the same form as the American Society of Mechanical Engineers (ASME) K{sub la} curve were fit to the data with only the {open_quotes}reference temperature{close_quotes} as a parameter. The shift between the mean curves agrees well with the 41-J transition temperature shift obtained from the CVN specimen tests. Moreover, the four data points resulting from tests on the duplex crack-arrest specimens of the present study did not make a significant change to mean curve fits to either the previously obtained data or all the data combined.

Iskander, S.K.; Corwin, W.R.; Nanstad, R.K. [Oak Ridge National Lab., TN (United States)

1994-03-01

95

Gas shows during construction of hydraulic tunnels  

Energy Technology Data Exchange (ETDEWEB)

The authors investigate the occurrence of and the geological factors behind rock bursts during the construction of diversion tunnels of five hydroelectric power plants located in the mountainous regions of the Caucasus. Gas migration and saturation behavior is explained for the various forms of strata and rock found in the region. Carbon dioxide and methane are determined to be the prevalent gases. The influence of the tectonics of the region is assessed. Corollaries to coal mining engineering are drawn. Water influx as a result of rock bursts is briefly discussed.

Razumov, V.K.; Skiba, S.I.

1987-10-01

96

Fuel ethanol from waste paper shows promise  

Energy Technology Data Exchange (ETDEWEB)

Stake Technology and Bio-hol Developments conducted a coordinated research program to develop an economically viable process for making ethanol from waste paper. The process utilizes the Stake Technology enzymatic hydrolysis process to convert the paper into a pure and easily fermentable product. Test results from the project indicate that a 50 million l/y ethanol plant could be commercially viable if the ethanol sold for 40 cents/l and if the plant charged a tipping fee of $50/tonne for the waste paper it accepted. Based on a yield of 350 liters ethanol per tonne of waste paper, the process has the potential to eliminate all waste paper generated in Ontario and to produce 1.2 billion l/y of ethanol. If the ethanol is used as a gasoline additive, this would result in an annual reduction of auto-related carbon dioxide emissions of 257,000 tonnes and a 2.5-7.5% reduction in CO emissions. 2 figs.

1992-12-01

97

Offshore technology stresses substance over show  

Energy Technology Data Exchange (ETDEWEB)

Emphasis these days continues to be on practical, cost-effective solutions to real problems. With a couple of exceptions, gone are the glitz and glamour of big-ticket items developed on speculation for projects and situations that don't yet exist. Manufacturers are cautiously spending money on R and D for more down-to-earth items. There seems to be a motto that ''less can be more,'' if researchers focus their limited resources on developing items that are more efficient, easier to install and operate, and save money. Items reviewed on this and other pages by WORLD OIL this year are certainly reflective of such attitudes. Short on show, but long on substance, they provide practical answers to everyday, routine problems encountered by offshore operators. They range from a subsea wireline lubricator developed by BP and Schlumberger, to a new ''armoring'' system that coats platform risers and saves them from the ravages of Mother Nature. There are also an electric safety valve and assorted other goodies. In addition, engineers have completed a fascinating study, which determined why some drilling vessels really sank during blowouts. It is incorrect to assume that large-sized innovations have disappeared completely. For instance, Conoco and others have designed a single-leg, tension-leg platform for Gulf of Mexico duty, which is featured below. Keep in mind, however, the primary motivation for this design was to improve logistics, shorten the timeframe, and save money.

Wright, T.R. Jr.; Abraham, K.S.

1988-07-01

98

Gasolines show varied responses to alcohols  

Energy Technology Data Exchange (ETDEWEB)

A discussion of some specific results of the research follows a presentation of the current situation regarding alcohol additives and gasoline. Work on the gasoline blending characteristics of alcohols, particularly those of the gasoline additive Oxinol, permits the comparison of their economic values relative to other octane enhancers, including refining processing options. Points out that the octane value of an alcohol is measured by its blending octane value (BOV). Gives the following conclusions about the BOV of alcohols: The (R+M)/2 BOV of Oxinol 50 in a series of different base stocks ranged from 105 to 113 and is independent of Oxinol 50 concentration; BOV calculations can be determined linearly from volume percent weighted Oxinol responses; Oxinol has a higher BOV in base stocks containing lead antiknocks; and ethanol and isopropanol compare favorably as higher octane blending components.

DeJovine, J.M.; Davis, B.C.; Douthit, W.H.; Guetens, E.G. Jr.; Hagstrom, P.E.; Yogis, G.I.

1983-02-14

99

Transition temperature tests show fracture behavior  

Energy Technology Data Exchange (ETDEWEB)

The objective of the research reported in this article was to examine the predictability of full-scale fracture behavior through the use of the fullthickness drop weight tear tests (DWTT) currently employed to specify high toughness, high-strength, lowalloy (HSLA) line pipe. The DWT tests studied are the standard pressed notch DWTT as specified by the American Petroleum Institute (DWTT-API), a recently developed precracked DWTT (DWTT-PC), and fatigue cracked DWTT (DWTTFC). The study was conducted at the brittle-ductile transition temperatures of the pipe steels to see which DWT test specimen most accurately defines the full-scale transition temperature. The main parameter of comparison between the full-scale tests and the DWT tests is the percent shear area appearance of the fractured surface. For normalized steels and smaller wall thickness, earlier investigations have shown that a good correlation exists between results of such fullscale tests and DWT-API tests. However, it must be verified that this correlation is also valid for modern HSLA steels and heavy wall thickness. From 17 pipes, 14 were produced from thermomechanically treated materials, and 3 were quenched and tempered.

Masey, W.A.; Junker, C.; Koch, F.O.; Kugler, J.; Peeck, A.; Peters, P.A.; Seifert, K.; Voght, G.H.

1985-04-23

100

Producing oil wells show a rare increase  

Energy Technology Data Exchange (ETDEWEB)

The number of oil wells producing in the U.S. increased for the first time since 1985. Based on an annual survey of state agencies, it is estimated that 613,810 wells were onstream at year-end 1991. This 1.9% increase over revised 1990 figures tracks similar gains in crude oil production and gas reserves, all of which resulted primarily from higher-than-expected well servicing and drilling in late 1990. This paper reports that the bad news is that the number of wells falling into the stripper category increased for the first time in recent years as more wells dropped below 10 bopd. Average daily U.S. production per well remained at about 12 bopd, but production for marginal wells dropped for the fourth straight year to average 2.26 bopd in 1990. In Oklahoma for example, where active oil producers increased by 5,094 or 5.3%, almost 85% of the artificial lift wells make less than 3 bopd according to the OCC.

1992-02-01

 
 
 
 
101

Do Education Organizations Show Learning Organizations Charecterics?  

Directory of Open Access Journals (Sweden)

Full Text Available Learning, an important element in terms of affecting the change of individual, organizational and social structures, will occur more effectively when the institutions in social structure turn into learning organizations. Senge (1993) concept of learning organization, constantly changing, evolving and renewing itself described as a dynamic structure. This concept has an important place in all institutions is also a separate meaning for educational institutions. In this context, schools training the human resources, appropriate for the aim of being information society, as individuals have taken continuous learning as their principles, teachers providing educational and supporting services and their perceptions of learning organization are of the great importance. In Bal?kesir, the study was conducted virtue of this importance has been serving the state and private institutions serving 848 elementary teachers, perceptions of the learning organization and organizational barriers that prevent it is to be determined through a comparative analysis. As a result of the survey, in the framework of the bases in literature, it has been found out that the state primary schools don’t have the features of learning organization, contrary to the private primary schools.

Sedat Yumusak,; Harun Yildiz

2011-01-01

102

Transition temperature tests show fracture behavior  

International Nuclear Information System (INIS)

The objective of the research reported in this article was to examine the predictability of full-scale fracture behavior through the use of the fullthickness drop weight tear tests (DWTT) currently employed to specify high toughness, high-strength, lowalloy (HSLA) line pipe. The DWT tests studied are the standard pressed notch DWTT as specified by the American Petroleum Institute (DWTT-API), a recently developed precracked DWTT (DWTT-PC), and fatigue cracked DWTT (DWTTFC). The study was conducted at the brittle-ductile transition temperatures of the pipe steels to see which DWT test specimen most accurately defines the full-scale transition temperature. The main parameter of comparison between the full-scale tests and the DWT tests is the percent shear area appearance of the fractured surface. For normalized steels and smaller wall thickness, earlier investigations have shown that a good correlation exists between results of such fullscale tests and DWT-API tests. However, it must be verified that this correlation is also valid for modern HSLA steels and heavy wall thickness. From 17 pipes, 14 were produced from thermomechanically treated materials, and 3 were quenched and tempered

1985-04-23

103

Does a lightning channel show a fractal?  

Energy Technology Data Exchange (ETDEWEB)

Forecasting the striking point of a lightning flash is important for the reduction of lightning hazards. Field campaigns have been conducted, and the features of leader progression have been investigated for this final goal. Both streak and still camera observations are used, because we can obtain useful information on the leader progression manner and its velocity. A radio interferometer is another useful instrument, by which, we can capture a lightning channel image from its initiation inside the thundercloud to the attachment process to the ground. Though many laborious investigations have been performed and various results have been presented, the exact forecasting of a striking point still remains difficult. To overcome this, numerical simulations of a stepped leader near the ground surface have been carried out using the leader progression model, which has been improved by using the fractal mathematical concept. In other words, the proposed scheme in this paper is a probabilistic procedure. The finite-difference approach is applied to the two-dimensional Poisson's equation to calculate the electric field produced by the charge distribution in a thundercloud. The stepped leaders, which are initiated at the lower part of the cloud and usually proceed towards the ground, are simulated to study the theoretical stepped leader progression. The zig-zags and branches of a lightning channel can also be simulated. (Author)

Kawasaki, Zen; Matsuura, Kenji [Osaka Univ., Dept. of Electrical Engineering, Suita Osaka (Japan)

2000-10-01

104

Do dwarf chameleons (Bradypodion) show developmental plasticity?  

Directory of Open Access Journals (Sweden)

Full Text Available Developmental plasticity results from environmental influences on the phenotype of an organism during its development, and its effects are irreversible. The phenomenon of phenotype–genotype uncoupling (plasticity) causes problems in species delineations, and has been suggested as a cause underlying a mismatch between morphology and genetics between the Natal Midlands dwarf chameleon (Bradypodion thamnobates) and the KwaZulu dwarf chameleon (Bradypodion melanocephalum). The two species are morphologically distinct, but are very poorly distinguished genetically. It has been hypothesized that B. melanocephalum and B. thamnobates may be phenotypically plastic populations of the same species, since environmental conditions, the driving force behind developmental plasticity, varies between the distributions of these two allopatric taxa.We raised juveniles of both species under identical controlled laboratory conditions. Two treatments were used. These varied in both habitat structure and temperature, each approximating conditions that one of the species would encounter naturally. Although not specifically controlled or monitored, all other environmental factors (e.g. humidity, light and wind) were standardized since chameleons were raised in the artificial conditions created in environmental chambers. If taxa are developmentally plastic, phenotypes would reflect treatment conditions, irrespective of specific associations. Neither B. thamnobates  nor B. melanocephalum  were phenotypically plastic over the environmental differences tested; species developed into the expected phenotypes, irrespective of treatment conditions. The low genetic difference between B. thamnobates and B. melanocephalum may indicate their recent divergence from a common ancestor or the mitochondrial gene fragments (ND2 and 16S) used in previously published phylogenetic analyses of the genus may not be representative of divergence for the genome as a whole.

Ashadee K. Miller; Graham J. Alexander

2011-01-01

105

Molars and incisors: show your microarray IDs.  

UK PubMed Central (United Kingdom)

BACKGROUND: One of the key questions in developmental biology is how, from a relatively small number of conserved signaling pathways, is it possible to generate organs displaying a wide range of shapes, tissue organization, and function. The dentition and its distinct specific tooth types represent a valuable system to address the issues of differential molecular signatures. To identify such signatures, we performed a comparative transcriptomic analysis of developing murine lower incisors, mandibular molars and maxillary molars at the developmental cap stage (E14.5). RESULTS: 231 genes were identified as being differentially expressed between mandibular incisors and molars, with a fold change higher than 2 and a false discovery rate lower than 0.1, whereas only 96 genes were discovered as being differentially expressed between mandibular and maxillary molars. Numerous genes belonging to specific signaling pathways (the Hedgehog, Notch, Wnt, FGF, TGF?/BMP, and retinoic acid pathways), and/or to the homeobox gene superfamily, were also uncovered when a less stringent fold change threshold was used. Differential expressions for 10 out of 12 (mandibular incisors versus molars) and 9 out of 10 selected genes were confirmed by quantitative reverse transcription-PCR (qRT-PCR). A bioinformatics tool (Ingenuity Pathway Analysis) used to analyze biological functions and pathways on the group of incisor versus molar differentially expressed genes revealed that 143 genes belonged to 9 networks with intermolecular connections. Networks with the highest significance scores were centered on the TNF/NF?B complex and the ERK1/2 kinases. Two networks ERK1/2 kinases and tretinoin were involved in differential molar morphogenesis. CONCLUSION: These data allowed us to build several regulatory networks that may distinguish incisor versus molar identity, and may be useful for further investigations of these tooth-specific ontogenetic programs. These programs may be dysregulated in transgenic animal models and related human diseases leading to dental anomalies.

Laugel-Haushalter V; Paschaki M; Thibault-Carpentier C; Dembelé D; Dollé P; Bloch-Zupan A

2013-01-01

106

TAPS repair shows value of deformation monitoring  

Energy Technology Data Exchange (ETDEWEB)

For Arctic pipelines, especially those built in river and floodplain areas, a monitoring system is essential for detecting impending pipe damage. This was a major lesson derived from last year's repair and rerouting of a section of the Trans-Alaska Pipeline (TAPS) at milepost (mp) 200. The line at this point crosses a river and floodplain area in which any surface evidence of pipe damage is obliterated, thus making ground surface conditions unreliable indicators of pipe settlement. The wintertime repair project, with rerouted pipe of about 4,000 ft long, cost $27 million. The affected pipe was buried beneath the main channel of the Dietrich River, 200.6 miles from the beginning of the pipeline at Prudhoe Bay, and 84 miles above the Arctic Circle. As part of Alyeska's continuing monitoring program, a corrosion and deformation (C/D) pig traverses the TAPS pipe at regular intervals. This pig has proven helpful in locating places where excessive settlement has caused deformation of the pipe. The C/D pig detects pipe diameter changes as small as 0.25 in. The radial and longitudinal locations of the pipe change have proven quite accurate. A review of the results of the June 1984 C/D pig run revealed a pipe wall ovality anomaly with a sinusoidal shape indicating a wrinkle. This wrinkle was small when compared with other wrinkles Alyeska had found and subsequently repaired. A comparison of previous C/D pig runs for this location revealed a wrinkle with an amplitude of 0.25 in. which had developed in previously smooth pipe in the space of a year.

Simmons, G.G.; Ferrell, J.F.

1986-04-07

107

Nissan at 33rd Tokyo Motor Show; Dai 33 kai Tokyo Motor show  

Energy Technology Data Exchange (ETDEWEB)

The Tokyo Motor Show is one of the leading exhibition opportunities for automobile companies world wide in terms of both scale and features, including the number of visitors as well as the devotion of each participant. For many years, we have worked hard to excell at each session of this show, (through the display of concept cars and Nissan Motor's technological developments), the show has played an increasing role in enhancing Nissan's brand image. At the 33rd Tokyo Motor Show in October 1999 was held at a time when Nissan had drawn the attention of the market because of its tic-up with Renault. Nissan demonstrated a revolutionary change through the introduction of concept cars, environmental technology, safety technology, new models, and so on. (author)

Sekiguchi, M. [Nissan Motor Co. Ltd., Tokyo (Japan)

2000-01-01

108

Glucosuria in Norwegian elkhounds and other breeds during dog shows.  

UK PubMed Central (United Kingdom)

Clinically healthy Norwegian elkhounds were tested for glucosuria by urine dipstick analysis and the results were compared with a group of dogs of other breeds during 15 dog shows. Fifty-two of 187 Norwegian elkhounds (27.3 per cent) and 15 of 202 dogs of other breeds (7.4 per cent) were glucosuric during the dog shows; the difference was statistically significant. Two of the glucosuric elkhounds and one non-glucosuric elkhound developed signs of kidney disease during the year of the study.

Heiene R; Bjørndal H; Indrebø A

2010-04-01

109

Glucosuria in Norwegian elkhounds and other breeds during dog shows.  

Science.gov (United States)

Clinically healthy Norwegian elkhounds were tested for glucosuria by urine dipstick analysis and the results were compared with a group of dogs of other breeds during 15 dog shows. Fifty-two of 187 Norwegian elkhounds (27.3 per cent) and 15 of 202 dogs of other breeds (7.4 per cent) were glucosuric during the dog shows; the difference was statistically significant. Two of the glucosuric elkhounds and one non-glucosuric elkhound developed signs of kidney disease during the year of the study. PMID:20382934

Heiene, R; Bjørndal, H; Indrebø, A

2010-04-10

110

UC Davis study shows how DNA finds its match  

Science.gov (United States)

It’s been more than 50 years since James Watson and Francis Crick showed that DNA is a double helix of two strands that complement each other. But how does a short piece of DNA find its match, out of the millions of "letters" in even a small genome? New work by researchers at the University of California, Davis, handling and observing single molecules of DNA, shows how it’s done. The results are published online Feb. 8 by the journal Nature.

111

Irradiation embrittlement of ASTM A533 steel: The UKAEA contribution to an IAEA comparative test programme  

International Nuclear Information System (INIS)

[en] Tensile, Charpy V notch impact and instrumented impact tests have been made on A533 Grade B Class 1 Steel as part of an IAEA co-ordinated testing programme. Tests were made to show the effect of irradiation at 290degC to a neutron dose of 1.75 x 1019n cm-2 (>1MeV). The results show an increase in strength and degree of embrittlement after irradiation which are lower than those determined in the ORNL facility and have demonstrated that it might be possible to use instrumented impact tests to give an estimate of dynamic fracture toughness data. (author)

1974-10-23

112

The neonicotinoid imidacloprid shows high chronic toxicity to mayfly nymphs.  

UK PubMed Central (United Kingdom)

The present study evaluated the acute and chronic toxicity of imidacloprid to a range of freshwater arthropods. Mayfly and caddisfly species were most sensitive to short-term imidacloprid exposures (10 tests), whereas the mayflies showed by far the most sensitive response to long-term exposure of all seven arthropod species tested (28-d EC10 values of approximately 0.03?µg/L). The results indicated a high aquatic risk of chronic exposure of imidacloprid to mayflies.

Roessink I; Merga LB; Zweers HJ; Van den Brink PJ

2013-04-01

113

The neonicotinoid imidacloprid shows high chronic toxicity to mayfly nymphs.  

Science.gov (United States)

The present study evaluated the acute and chronic toxicity of imidacloprid to a range of freshwater arthropods. Mayfly and caddisfly species were most sensitive to short-term imidacloprid exposures (10 tests), whereas the mayflies showed by far the most sensitive response to long-term exposure of all seven arthropod species tested (28-d EC10 values of approximately 0.03?µg/L). The results indicated a high aquatic risk of chronic exposure of imidacloprid to mayflies. PMID:23444274

Roessink, Ivo; Merga, Lemessa B; Zweers, Hans J; Van den Brink, Paul J

2013-04-03

114

Synthesis and evaluation of dioleoyl glyceric acids showing antitrypsin activity.  

Science.gov (United States)

Previously, Lešová et al. reported the isolation and identification of metabolite OR-1, showing antitrypsin activity, produced during fermentation by Penicillium funiculosum. The structure of OR-1 was a mixture of glyceric acid (GA), esterified with C(14)-C(18) fatty acids, and oleic acid (C18:1) as the most predominant fatty acid (Folia Microbiol. 46, 21-23, 2001). In this study, dioleoyl D-GA and dioleoyl L-GA were synthesized via diesterification with oleoyl chloride, and their antitrypsin activities were evaluated using both a disk diffusion method and spectral absorption measurements. The results show that both compounds and their equivalent mixtures possess antitrypsin activities; however, their IC(50) values (approximately 2 mM) are much higher than that of OR-1 (4.25 µM), suggesting that dioleoyl GA does not play a major role in the OR-1 antitrypsin activity. PMID:21606621

Habe, Hiroshi; Fukuoka, Tokuma; Sato, Shun; Kitamoto, Dai; Sakaki, Keiji

2011-01-01

115

Synthesis and evaluation of dioleoyl glyceric acids showing antitrypsin activity.  

UK PubMed Central (United Kingdom)

Previously, Lešová et al. reported the isolation and identification of metabolite OR-1, showing antitrypsin activity, produced during fermentation by Penicillium funiculosum. The structure of OR-1 was a mixture of glyceric acid (GA), esterified with C(14)-C(18) fatty acids, and oleic acid (C18:1) as the most predominant fatty acid (Folia Microbiol. 46, 21-23, 2001). In this study, dioleoyl D-GA and dioleoyl L-GA were synthesized via diesterification with oleoyl chloride, and their antitrypsin activities were evaluated using both a disk diffusion method and spectral absorption measurements. The results show that both compounds and their equivalent mixtures possess antitrypsin activities; however, their IC(50) values (approximately 2 mM) are much higher than that of OR-1 (4.25 µM), suggesting that dioleoyl GA does not play a major role in the OR-1 antitrypsin activity.

Habe H; Fukuoka T; Sato S; Kitamoto D; Sakaki K

2011-01-01

116

Variation in training regimens in professional show jumping yards.  

UK PubMed Central (United Kingdom)

REASONS FOR PERFORMING STUDY: Training regimens of show jumping horses under field conditions are largely undocumented. OBJECTIVES: The aims of this study were to quantify and compare training regimens used in professional level show jumping yards, with respect to time exercised and type of activity. STUDY DESIGN: Prospective cohort study. METHODS: A prospective 6-month cohort study of show jumping horses in 4 European countries (the Netherlands, Sweden, Switzerland, Great Britain) was designed to analyse training and health data, in yards with several horses in training and riders competing at professional level. Riders documented the daily frequency and duration of all physical activities of the horses. Variation in training routines were compared between riders, location and time. Mixed models analysis was used to examine factors associated with total time exercised and time spent in flatwork. RESULTS: In 4 countries, the 31 participating riders trained 263 European Warmbloods. The total days at risk (i.e. days in which the horses were considered fit for exercise) were 39,262. Mean time spent in daily exercise, including ridden work, lungeing and treadmill exercise, varied between riders from 19-52 min per day at risk. There was considerable variation in activities and level of heavy work and light exercise, e.g. turnout. Total time exercised and time spent in flatwork differed with month, country and proportion of days lost to training. Low variation of activities was associated with decreased total time trained and increased time spent in flatwork. CONCLUSIONS: Riders at this elite professional level of show jumping used training regimens which vary substantially in time spent training and other physical activities and show jumping horses are challenged differently during training despite competing at the same level. Whether all training regimens prepare the horses equally for the demands of competition remains to be determined.

Lönnell AC; Bröjer J; Nostell K; Hernlund E; Roepstorff L; Tranquille CA; Murray RC; Oomen A; van Weeren R; Bitschnau C; Montavon S; Weishaupt MA; Egenvall A

2013-06-01

117

GAMS results  

International Nuclear Information System (INIS)

In this contribution some recent results of the GAMS collaboration are shown. Some of them are still preliminary. Results on the following reactions are presented: ?-p ? (? ?0) n, ?-p ? (? ?0) n, and ?-p? ?-p (??) centrally produced. (orig.)

1991-01-01

118

Influence of process parameters on the weld lines of a micro injection molded component  

DEFF Research Database (Denmark)

The insufficient entanglement of the molecular chains and the stress amplification at the v-notch of a weld line compromise the mechanical strength of a plastic product, also in the micro scale. To investigate the influence of process parameters on the weld lines formation, a special micro cavity was designed and manufactured by µEDM (Electro Discharge Machining). Weld lines were quantitatively characterized both in the two-dimensional (direction and position) and three-dimensional range (surface topography characterization). Results showed that shape and position of weld lines are mainly influenced by mold temperature and injection speed.

Tosello, Guido; Gava, Alberto

2007-01-01

119

New World cattle show ancestry from multiple independent domestication events.  

UK PubMed Central (United Kingdom)

Previous archeological and genetic research has shown that modern cattle breeds are descended from multiple independent domestication events of the wild aurochs (Bos primigenius) ?10,000 y ago. Two primary areas of domestication in the Middle East/Europe and the Indian subcontinent resulted in taurine and indicine lines of cattle, respectively. American descendants of cattle brought by European explorers to the New World beginning in 1493 generally have been considered to belong to the taurine lineage. Our analyses of 47,506 single nucleotide polymorphisms show that these New World cattle breeds, as well as many related breeds of cattle in southern Europe, actually exhibit ancestry from both the taurine and indicine lineages. In this study, we show that, although European cattle are largely descended from the taurine lineage, gene flow from African cattle (partially of indicine origin) contributed substantial genomic components to both southern European cattle breeds and their New World descendants. New World cattle breeds, such as Texas Longhorns, provide an opportunity to study global population structure and domestication in cattle. Following their introduction into the Americas in the late 1400s, semiferal herds of cattle underwent between 80 and 200 generations of predominantly natural selection, as opposed to the human-mediated artificial selection of Old World breeding programs. Our analyses of global cattle breed population history show that the hybrid ancestry of New World breeds contributed genetic variation that likely facilitated the adaptation of these breeds to a novel environment.

McTavish EJ; Decker JE; Schnabel RD; Taylor JF; Hillis DM

2013-04-01

120

The postmitotic Saccharomyces cerevisiae after spaceflight showed higher viability  

Science.gov (United States)

The budding yeast Saccharomyces cerevisiae has been proposed as an ideal model organism for clarifying the biological effects caused by spaceflight conditions. The postmitotic S. cerevisiae cells onboard Practice eight recoverable satellite were subjected to spaceflight for 15 days. After recovery, the viability, the glycogen content, the activities of carbohydrate metabolism enzymes, the DNA content and the lipid peroxidation level in yeast cells were analyzed. The viability of the postmitotic yeast cells after spaceflight showed a three-fold increase as compared with that of the ground control cells. Compared to the ground control cells, the lipid peroxidation level in the spaceflight yeast cells markedly decreased. The spaceflight yeast cells also showed an increase in G2/M cell population and a decrease in Sub-G1 cell population. The glycogen content and the activities of hexokinase and succinate dehydrogenase significantly decreased in the yeast cells after spaceflight. In contrast, the activity of malate dehydrogenase showed an obvious increase after spaceflight. These results suggested that microgravity or spaceflight could promote the survival of postmitotic S. cerevisiae cells through regulating carbohydrate metabolism, ROS level and cell cycle progression.

Yi, Zong-Chun; Li, Xiao-Fei; Wang, Yan; Wang, Jie; Sun, Yan; Zhuang, Feng-Yuan

2011-06-01

 
 
 
 
121

Radon in Austrian tourist mines and show caves  

International Nuclear Information System (INIS)

The radon situation in tourist mines and show caves is barely investigated in Austria. This paper investigates the influence of its determining factors, such as climate, structure and geology. For this purpose, long-term time-resolved measurements over 6 to 12 months in 4 tourist mines and 2 show caves - with 5 to 9 measuring points each - have been carried out to obtain the course of radon concentration throughout the year. In addition, temperature and air-pressure were measured and compared to the data outside where available. Results suggest that the dominating factors of the average radon concentration are structure and location (geology) of the tunnel-system, whereas the diurnal and annual variation is mainly caused by the changing airflow, which is driven by the difference in temperature inside and outside. Downcast air is connected with very low radon concentrations, upcast air with high concentrations. In some locations the maximum values appear when the airflow ceases. But airflow can be different in different parts of mines and caves. Systems close to the surface show generally lower radon levels than the ones located deeper underground. Due to variation of structure, geology and local climate, the radon situation in mines and caves can only be described by simultaneous measurements at several measuring points. (orig.)

2009-01-01

122

Delivering Results  

CERN Document Server

Shows managers how to avoid the common pitfalls and mistakes when setting corporate strategy. This book illustrates the authors' concepts with numerous real-life examples, practical tools and models, and a glossary of key terms. It acknowledges that designing and implementing an effective management system can be daunting for many reasons

Carr, Lawrence P

2009-01-01

123

Phytoceramide Shows Neuroprotection and Ameliorates Scopolamine-Induced Memory Impairment  

Directory of Open Access Journals (Sweden)

Full Text Available The function and the role phytoceramide (PCER) and phytosphingosine (PSO) in the central nervous system has not been well studied. This study was aimed at investigating the possible roles of PCER and PSO in glutamate-induced neurotoxicity in cultured neuronal cells and memory function in mice. Phytoceramide showed neuro-protective activity in the glutamate-induced toxicity in cultured cortical neuronal cells. Neither phytosphingosine nor tetraacetylphytosphingosine (TAPS) showed neuroproective effects in neuronal cells. PCER (50 mg/kg, p.o.) recovered the scopolamine-induced reduction in step-through latency in the passive avoidance test; however, PSO did not modulate memory function on this task. The ameliorating effects of PCER on spatial memory were confirmed by the Morris water maze test. In conclusion, through behavioral and neurochemical experimental results, it was demonstrated that central administration of PCER produces amelioration of memory impairment. These results suggest that PCER plays an important role in neuroprotection and memory enhancement and PCER could be a potential new therapeutic agent for the treatment of neurodegenerative diseases such as Alzheimer’s disease.

Jae-Chul Jung; Yeonju Lee; Sohyeon Moon; Jong Hoon Ryu; Seikwan Oh

2011-01-01

124

Extracorporeal shockwave therapy shows chondroprotective effects in osteoarthritic rat knee.  

UK PubMed Central (United Kingdom)

PURPOSE: This study investigated the effects of extracorporeal shockwave therapy (ESWT) on the subchondral bone and articular cartilage in the initiation of osteoarthritis of the knee in rats. METHODS: Anterior cruciate ligament transected (ACLT) osteoarthritis (OA) rat knee model was used in this study. Twenty-seven male Sprague-Dawley rats were divided into three groups. The control group underwent sham surgery without ACLT and received no ESWT. The ACLT group underwent ACLT, but received no ESWT. The ACLT plus ESWT group underwent ACLT and received ESWT immediately after surgery. The evaluation parameters included radiograph, bone mineral density, serum levels of cartilage oligometric protein and osteocalcin, and urinary concentration of C-telopeptide of type II collagen (CTX-II), and histomorphological examination. RESULTS: At 12 weeks, OA of the knee was radiographically verified in the ACLT group, but very subtle changes were noticed in the control and the ACLT plus ESWT groups. On articular cartilage, the ACLT group showed significant increases in cartilage degradation and chondrocyte apoptosis compared to the control and ACLT plus ESWT groups. The ACLT plus ESWT group demonstrated significant decrease in the cartilage degradation and an increase in chondrocyte activity comparable to the control. In subchondral bone, the ACLT group showed a significant decrease in bone remodeling as compared to the control and ACLT plus ESWT groups. The ACLT plus ESWT group showed significant improvement in bone remodeling comparable to the control. CONCLUSION: Extracorporeal shockwave therapy shows chondroprotective effect associated with improvement in subchondral bone remodeling in the initiation of ACLT OA knee model in rats.

Wang CJ; Weng LH; Ko JY; Sun YC; Yang YJ; Wang FS

2011-08-01

125

GAMS results  

Energy Technology Data Exchange (ETDEWEB)

In this contribution some recent results of the GAMS collaboration are shown. Some of them are still preliminary. Results on the following reactions are presented: {pi}{sup -}p {yields} ({eta} {pi}{sup 0}) n, {pi}{sup -}p {yields} ({omega} {pi}{sup 0}) n, and {pi}{sup -}p{yields} {pi}{sup -}p ({eta}{eta}) centrally produced. (orig.).

Boutemeur, M. (CERN, Geneva (Switzerland)); Peigneux, J.P. (Grenoble-1 Univ., 74 - Annecy (France). Lab. de Physique des Particules); Donskov, S.V.; Inyakin, A.V.; Kachanov, V.A.; Khaustov, G.V.; Kulik, A.V.; Lednev, A.A.; Prokoshkin, Yu.D.; Rodnov, Yu.V.; Sadovsky, S.A.; Samoylenko, V.D.; Shagin, P.M.; Shtannikov, A.V.; Singovsky, A.V.; Sugonyaev, V.P. (Institute for High Energy Physics, Serpukhov (USSR)); Binon, F.G.; Bricman, C.; Stroot, J.P. (Institut Interuniversitaire des Sciences Nucleaires, Brussels (Belgium)); Bencheikh, B.; Boutemeur, M.; Gouanere, M.; Massonnett, L.; Peigneux, J.P.; Poulet, M. (Grenoble-1 Univ., 74 - Annecy (France). Lab. de Physique des Particules); Alde, D.; Jeppesen, R.G.; Knapp, E.A. (Los Alamos National Lab., NM (USA)); Bellazini, R.; Brez, A.; Massai, M.M.; Torquati, M.R. (Pisa Univ. (Italy) INFN, Pisa (Italy)); Inaba, S.; Kobayashi, M.; Shimizu, H.; Takamatsu, K.; Tsuru, T. (National Lab. for High Energy Physics, Tsukuba (Japan)); GAMS Collaboration

1991-06-01

126

Research Results  

Science.gov (United States)

Research on Global Carbon Emission and Sequestration NSFC Funded Project Made Significant Progress in Quantum Dynamics Functional Human Blood Protein Obtained from Rice How Giant Pandas Thrive on a Bamboo Diet New Evidence of Interpersonal Violence from 129,000 Years Ago Found in China Aptamer-Mediated Efficient Capture and Release of T Lymphocytes on Nanostructured Surfaces BGI Study Results on Resequencing 50 Accessions of Rice Cast New Light on Molecular Breeding BGI Reports Study Results on Frequent Mutation of Genes Encoding UMPP Components in Kidney Cancer Research on Habitat Shift Promoting Species Diversification

2011-12-01

127

Clonally related visual cortical neurons show similar stimulus feature selectivity.  

Science.gov (United States)

A fundamental feature of the mammalian neocortex is its columnar organization. In the visual cortex, functional columns consisting of neurons with similar orientation preferences have been characterized extensively, but how these columns are constructed during development remains unclear. The radial unit hypothesis posits that the ontogenetic columns formed by clonally related neurons migrating along the same radial glial fibre during corticogenesis provide the basis for functional columns in adult neocortex. However, a direct correspondence between the ontogenetic and functional columns has not been demonstrated. Here we show that, despite the lack of a discernible orientation map in mouse visual cortex, sister neurons in the same radial clone exhibit similar orientation preferences. Using a retroviral vector encoding green fluorescent protein to label radial clones of excitatory neurons, and in vivo two-photon calcium imaging to measure neuronal response properties, we found that sister neurons preferred similar orientations whereas nearby non-sister neurons showed no such relationship. Interestingly, disruption of gap junction coupling by viral expression of a dominant-negative mutant of Cx26 (also known as Gjb2) or by daily administration of a gap junction blocker, carbenoxolone, during the first postnatal week greatly diminished the functional similarity between sister neurons, suggesting that the maturation of ontogenetic into functional columns requires intercellular communication through gap junctions. Together with the recent finding of preferential excitatory connections among sister neurons, our results support the radial unit hypothesis and unify the ontogenetic and functional columns in the visual cortex. PMID:22678292

Li, Ye; Lu, Hui; Cheng, Pei-lin; Ge, Shaoyu; Xu, Huatai; Shi, Song-Hai; Dan, Yang

2012-05-02

128

Clonally related visual cortical neurons show similar stimulus feature selectivity.  

UK PubMed Central (United Kingdom)

A fundamental feature of the mammalian neocortex is its columnar organization. In the visual cortex, functional columns consisting of neurons with similar orientation preferences have been characterized extensively, but how these columns are constructed during development remains unclear. The radial unit hypothesis posits that the ontogenetic columns formed by clonally related neurons migrating along the same radial glial fibre during corticogenesis provide the basis for functional columns in adult neocortex. However, a direct correspondence between the ontogenetic and functional columns has not been demonstrated. Here we show that, despite the lack of a discernible orientation map in mouse visual cortex, sister neurons in the same radial clone exhibit similar orientation preferences. Using a retroviral vector encoding green fluorescent protein to label radial clones of excitatory neurons, and in vivo two-photon calcium imaging to measure neuronal response properties, we found that sister neurons preferred similar orientations whereas nearby non-sister neurons showed no such relationship. Interestingly, disruption of gap junction coupling by viral expression of a dominant-negative mutant of Cx26 (also known as Gjb2) or by daily administration of a gap junction blocker, carbenoxolone, during the first postnatal week greatly diminished the functional similarity between sister neurons, suggesting that the maturation of ontogenetic into functional columns requires intercellular communication through gap junctions. Together with the recent finding of preferential excitatory connections among sister neurons, our results support the radial unit hypothesis and unify the ontogenetic and functional columns in the visual cortex.

Li Y; Lu H; Cheng PL; Ge S; Xu H; Shi SH; Dan Y

2012-06-01

129

Three sympatrically occurring species of Metarhizium show plant rhizosphere specificity.  

UK PubMed Central (United Kingdom)

Here we tested the hypothesis that species of the soil-inhabiting insect-pathogenic fungus Metarhizium are not randomly distributed in soils but show plant-rhizosphere-specific associations. We isolated Metarhizium from plant roots at two sites in Ontario, Canada, sequenced the 5' EF-1? gene to discern Metarhizium species, and developed an RFLP test for rapid species identification. Results indicated a non-random association of three Metarhizium species (Metarhizium robertsii, Metarhizium brunneum and Metarhizium guizhouense) with the rhizosphere of certain types of plant species (identified to species and categorized as grasses, wildflowers, shrubs and trees). M. robertsii was the only species that was found associated with grass roots, suggesting a possible exclusion of M. brunneum and M. guizhouense. Supporting this, in vitro experiments showed that M. robertsii conidia germinated significantly better in Panicum virgatum (switchgrass) root exudate than did M. brunneum or M. guizhouense. M. guizhouense and M. brunneum only associated with wildflower rhizosphere when co-occurring with M. robertsii. With the exception of these co-occurrences, M. guizhouense was found to associate exclusively with the rhizosphere of tree species, predominantly Acer saccharum (sugar maple), while M. brunneum was found to associate exclusively with the rhizosphere of shrubs and trees. These associations demonstrate that different species of Metarhizium associate with specific plant types.

Wyrebek M; Huber C; Sasan RK; Bidochka MJ

2011-10-01

130

Three sympatrically occurring species of Metarhizium show plant rhizosphere specificity.  

Science.gov (United States)

Here we tested the hypothesis that species of the soil-inhabiting insect-pathogenic fungus Metarhizium are not randomly distributed in soils but show plant-rhizosphere-specific associations. We isolated Metarhizium from plant roots at two sites in Ontario, Canada, sequenced the 5' EF-1? gene to discern Metarhizium species, and developed an RFLP test for rapid species identification. Results indicated a non-random association of three Metarhizium species (Metarhizium robertsii, Metarhizium brunneum and Metarhizium guizhouense) with the rhizosphere of certain types of plant species (identified to species and categorized as grasses, wildflowers, shrubs and trees). M. robertsii was the only species that was found associated with grass roots, suggesting a possible exclusion of M. brunneum and M. guizhouense. Supporting this, in vitro experiments showed that M. robertsii conidia germinated significantly better in Panicum virgatum (switchgrass) root exudate than did M. brunneum or M. guizhouense. M. guizhouense and M. brunneum only associated with wildflower rhizosphere when co-occurring with M. robertsii. With the exception of these co-occurrences, M. guizhouense was found to associate exclusively with the rhizosphere of tree species, predominantly Acer saccharum (sugar maple), while M. brunneum was found to associate exclusively with the rhizosphere of shrubs and trees. These associations demonstrate that different species of Metarhizium associate with specific plant types. PMID:21778205

Wyrebek, Michael; Huber, Cristina; Sasan, Ramanpreet Kaur; Bidochka, Michael J

2011-07-21

131

Tropical Aquatic Archaea Show Environment-Specific Community Composition  

Science.gov (United States)

The Archaea domain is ubiquitously distributed and extremely diverse, however, environmental factors that shape archaeal community structure are not well known. Aquatic environments, including the water column and sediments harbor many new uncultured archaeal species from which metabolic and ecological roles remain elusive. Some environments are especially neglected in terms of archaeal diversity, as is the case of pristine tropical areas. Here we investigate the archaeal composition in marine and freshwater systems from Ilha Grande, a South Atlantic tropical environment. All sampled habitats showed high archaeal diversity. No OTUs were shared between freshwater, marine and mangrove sediment samples, yet these environments are interconnected and geographically close, indicating environment-specific community structuring. Group II Euryarchaeota was the main clade in marine samples, while the new putative phylum Thaumarchaeota and LDS/RCV Euryarchaeota dominated freshwaters. Group III Euryarchaeota, a rare clade, was also retrieved in reasonable abundance in marine samples. The archaeal community from mangrove sediments was composed mainly by members of mesophilic Crenarchaeota and by a distinct clade forming a sister-group to Crenarchaeota and Thaumarchaeota. Our results show strong environment-specific community structuring in tropical aquatic Archaea, as previously seen for Bacteria.

Silveira, Cynthia B.; Cardoso, Alexander M.; Coutinho, Felipe H.; Lima, Joyce L.; Pinto, Leonardo H.; Albano, Rodolpho M.; Clementino, Maysa M.; Martins, Orlando B.; Vieira, Ricardo P.

2013-01-01

132

Synthesis of ?-1,3-glucan esters showing nanosphere formation.  

Science.gov (United States)

Polysaccharide nanoparticles are versatile functional materials used in drug delivery applications. Here we describe a method for the synthesis of ?-1,3-glucan esters which show the formation of nanoparticles. Pyridine-soluble ?-1,3-glucan formate was first synthesized as an intermediate and then reacted with various anhydrates to yield ?-1,3-glucan acetate and hexaonate. The resultant esters were soluble in common organic solvents like acetone, pyridine and dimethylacetamide. By using a simple dialysis process, homogeneous hollow or solid nanospheres with diameter from 132 to 487 nm were prepared. The chemical structures of the obtained ?-1,3-glucan esters were characterized and the morphologies of the ?-1,3-glucan based nanoparticles were evaluated. These new types of nanoparticles could be potentially used for the encapsulation of hydrophobic drugs targeting immune cells. PMID:23987415

Wu, Chaoxi; Chu, Bin; Kuang, Longzhao; Meng, Beibei; Wang, Xiaoying; Tang, Shunqing

2013-07-03

133

Cutaneous lesions showing giant yeast forms of Blastomyces dermatitidis.  

UK PubMed Central (United Kingdom)

BACKGROUND: The yeast forms of Blastomyces dermatitidis usually range from 8 to 15-20 micro m in diameter. Larger yeast forms have previously been reported only twice in immunosuppressed patients. In both patients these large forms were seen within the lung. CASE REPORT: We present a 14-year-old cardiac transplant patient, who presented 36 days following his transplantation with acute respiratory distress followed a few days later by erythematous cutaneous papules. RESULTS: Biopsy of a skin lesion showed yeast forms, some greater than 40 micro m in diameter, within and surrounding dermal vessels. Cultures later grew Blastomyces dermatitidis. CONCLUSIONS: To our knowledge this is the first reported case of giant forms of Blastomyces dermatitidis within the skin. With increased iatrogenic immunosuppression, we may expect to see more diverse morphologic forms with deep fungal infections.

Walker K; Skelton H; Smith K

2002-11-01

134

Testosterone gel shows promise in Phase III trial.  

Science.gov (United States)

Early results from a Phase III trial of Androgel, a testosterone replacement gel developed by Unimed Pharmaceuticals, shows that it effectively restores testosterone serum levels without skin irritation. The transdermal delivery has been found to adequately replace the hormone, and is easy to apply. The study did not target AIDS patients, but other studies have shown that testosterone-replacement therapy is effective in regaining muscle mass and improving the physical and mental state of HIV-positive patients. The drug will be sold in doses of 25 mg-dose packages, and clinicians will be able to prescribe two- or four-package doses as appropriate. Europeans have administered androgens in a gel form for over 15 years, but this is the first time such a product will be available in the United States. Unimed plans to submit the drug for Food and Drug Administration (FDA) approval soon. PMID:11366410

1999-06-01

135

Bex1 knock out mice show altered skeletal muscle regeneration  

International Nuclear Information System (INIS)

Bex1 and Calmodulin (CaM) are upregulated during skeletal muscle regeneration. We confirm this finding and demonstrate the novel finding that they interact in a calcium-dependent manner. To study the role of Bex1 and its interaction with CaM in skeletal muscle regeneration, we generated Bex1 knock out (Bex1-KO) mice. These mice appeared to develop normally and are fertile, but displayed a functional deficit in exercise performance compared to wild type (WT) mice. After intramuscular injection of cardiotoxin, which causes extensive and reproducible myotrauma followed by recovery, regenerating muscles of Bex1-KO mice exhibited elevated and prolonged cell proliferation, as well as delayed cell differentiation, compared to WT mice. Thus, our results provide the first evidence that Bex1-KO mice show altered muscle regeneration, and allow us to propose that the interaction of Bex1 with Ca2+/CaM may be involved in skeletal muscle regeneration

2007-11-16

136

Synthesis of ?-1,3-glucan esters showing nanosphere formation.  

UK PubMed Central (United Kingdom)

Polysaccharide nanoparticles are versatile functional materials used in drug delivery applications. Here we describe a method for the synthesis of ?-1,3-glucan esters which show the formation of nanoparticles. Pyridine-soluble ?-1,3-glucan formate was first synthesized as an intermediate and then reacted with various anhydrates to yield ?-1,3-glucan acetate and hexaonate. The resultant esters were soluble in common organic solvents like acetone, pyridine and dimethylacetamide. By using a simple dialysis process, homogeneous hollow or solid nanospheres with diameter from 132 to 487nm were prepared. The chemical structures of the obtained ?-1,3-glucan esters were characterized and the morphologies of the ?-1,3-glucan based nanoparticles were evaluated. These new types of nanoparticles could be potentially used for the encapsulation of hydrophobic drugs targeting immune cells.

Wu C; Chu B; Kuang L; Meng B; Wang X; Tang S

2013-10-01

137

Ganil results  

International Nuclear Information System (INIS)

[en] Recent Ganil results are presented: hot nuclei properties and multifragmentation, study of flow change around the inversion energy. Mesons and hard photons production are also briefly discussed. Correlations with studies that have been led in Saturne energy range, and the developments that can be foreseen in the future have been discussed

1992-01-01

138

Extraordinary results  

International Nuclear Information System (INIS)

For the first time in the history, Slovenske elektrarne became the first winner in a new category Business and Biodiversity in the competition of European companies aimed at the environment protection. Excellent results were achieved by a long-term co-operation with the Tatras National Park, in particular in saving the endangered animals.

2012-01-01

139

PROTOTIPE VIDEO EDITOR DENGAN MENGGUNAKAN DIRECT X DAN DIRECT SHOW  

Directory of Open Access Journals (Sweden)

Full Text Available Technology development had given people the chance to capture their memorable moments in video format. A high quality digital video is a result of a good editing process. Which in turn, arise the new need of an editor application. In accordance to the problem, here the process of making a simple application for video editing needs. The application development use the programming techniques often applied in multimedia applications, especially video. First part of the application will begin with the video file compression and decompression, then we'll step into the editing part of the digital video file. Furthermore, the application also equipped with the facilities needed for the editing processes. The application made with Microsoft Visual C++ with DirectX technology, particularly DirectShow. The application provides basic facilities that will help the editing process of a digital video file. The application will produce an AVI format file after the editing process is finished. Through the testing process of this application shows the ability of this application to do the 'cut' and 'insert' of video files in AVI, MPEG, MPG and DAT formats. The 'cut' and 'insert' process only can be done in static order. Further, the aplication also provide the effects facility for transition process in each clip. Lastly, the process of saving the new edited video file in AVI format from the application. Abstract in Bahasa Indonesia : Perkembangan teknologi memberi kesempatan masyarakat untuk mengabadikan saat - saat yang penting menggunakan video. Pembentukan video digital yang baik membutuhkan proses editing yang baik pula. Untuk melakukan proses editing video digital dibutuhkan program editor. Berdasarkan permasalahan diatas maka pada penelitian ini dibuat prototipe editor sederhana untuk video digital. Pembuatan aplikasi memakai teknik pemrograman di bidang multimedia, khususnya video. Perencanaan dalam pembuatan aplikasi tersebut dimulai dengan pembentukan kompresi dan dekompresi file video, kemudian dilanjutkan dengan proses editing terhadap file video digital. Selain itu program juga dilengkapi dengan fasilitas untuk mendukung proses editing. Aplikasi tersebut dibuat dengan Microsoft Visual C++ dengan menggunakan teknologi DirectX, khususnya DirectShow. Aplikasi tersebut meyediakan fasilitas - fasilitas dasar yang membantu proses editing pada video digital. Dengan aplikasi tersebut dihasilkan file video baru dalam format AVI yang terbentuk dari proses editing yang dilakukan. Hasil pengujian menunjukkan kemampuan aplikasi melakukan proses pemotongan dan penyisipan file video dalam format AVI, MPEG, MPG dan DAT. Proses pemotongan dan penyisipan dilakukan dengan urutan yang statis. Selain itu aplikasi juga menyediakan efek antara masing - masing clip. Dan yang terakhir melakukan proses penyimpanan satu file dalam format AVI yang terbentuk dari proses editing dalam aplikasi. Kata kunci: Multimedia, Video Editor, Direct-X, Direct-Show, AVI, MPG.

Djoni Haryadi Setiabudi; Teguh Mujianto; Ibnu Gunawan

2004-01-01

140

GAMS results  

International Nuclear Information System (INIS)

The author emphasizes results of the GAMS Collaboration related to various subjects which have been approached during the last one and a half day. Five Institutes are involved in the GAMS Collaboration: IISN, IHEP, INFN, LAPP, LANL which are exploiting two experimental setups: one at IHEP (Serpukhov), known as GAMS-2000, the second at CERN (NA12 experiment), known as GAMS-4000. The results presented have mainly been obtained in the study of the exclusive reaction ?-p ? M0n where M0 decays finally into m? where m can reach a value as large as 12. Four topics are presented: ? decays, ?' decays, f0 (1590), first evidence for an exotic meson in the ??0 channel

1988-01-01

 
 
 
 
141

Aleph results  

International Nuclear Information System (INIS)

The results obtained by the ALEPH collaboration during the 1989 run are presented. On the basis of ? 20 000 Z decays we find Mz = 91.182 ± 0.026 (exp) ± 0.030 (LEP) Gev, ?z = 2.541 ± 0.056 Gev, ?l = 83.9 ± 2.2 Mev, ?h = 1804 ± 44 Mev, ?inv = 485 ± 41 Mev. Searching for the neutral Higgs boson we exclude at 95% confidence level the mass range between 32 MeV and 24 Gev.

1990-01-01

142

SAGE results  

Energy Technology Data Exchange (ETDEWEB)

The Russian-American Gallium solar neutrino Experiment (SAGE) is described. The solar neutrino flux measured by 31 extractions through October, 1993 is presented. The result of 69+/-10(stat)+5/-7(syst) SNU is to be compared with a Standard Solar Model prediction of 132 SNU. The initial results of a measurement of experimental efficiencies are also discussed by exposing the gallium target to neutrinos from an artificial source. The capture rate of neutrinos from this source is very close to that which is expected. The result can be expressed as a ratio of the measured capture rate to the anticipated rate from the source activity. This ratio is 0.93+0.15, -0.17 where the systematic and statistical errors have been combined. To first order the experimental efficiencies are in agreement with those determined during solar neutrino measurements and in previous auxiliary measurements. One must conclude that the discrepancy between the measured solar neutrino flux and that predicted by the solar models can not arise from an experimental artifact. (author) 19 refs.

Gavrin, V.N. [Russian Academy of Sciences, Moscow (Russian Federation). Inst. of Nuclear Research; SAGE Collaboration

1996-12-31

143

SAGE results  

International Nuclear Information System (INIS)

The Russian-American Gallium solar neutrino Experiment (SAGE) is described. The solar neutrino flux measured by 31 extractions through October, 1993 is presented. The result of 69+/-10(stat)+5/-7(syst) SNU is to be compared with a Standard Solar Model prediction of 132 SNU. The initial results of a measurement of experimental efficiencies are also discussed by exposing the gallium target to neutrinos from an artificial source. The capture rate of neutrinos from this source is very close to that which is expected. The result can be expressed as a ratio of the measured capture rate to the anticipated rate from the source activity. This ratio is 0.93+0.15, -0.17 where the systematic and statistical errors have been combined. To first order the experimental efficiencies are in agreement with those determined during solar neutrino measurements and in previous auxiliary measurements. One must conclude that the discrepancy between the measured solar neutrino flux and that predicted by the solar models can not arise from an experimental artifact. (author)

1996-01-01

144

Management in a neotropical show cave: planning for invertebrates conservation  

Directory of Open Access Journals (Sweden)

Full Text Available Lapa Nova is a dolomitic cave about 4.5 km long located in northwestern Minas Gerais state, Brazil. The cave experiences intense tourism, concentrated over a single period of the year, during the Feast of Our Lady of Lapa. In order to evaluate the impacts felt by the invertebrate community from this tourism, a new methodology was proposed. Four types of areas (intense visitation area, outlying visitation areas, moderate visitation areas and no-visitation areas) were sampled for invertebrates. There was one sampling prior and another on the last day of the 128th feast, to evaluate the effects of visitation on cave-dwelling invertebrates. Results show that invertebrate populations residing in more intensely visited areas of the cave undergo changes in distribution following the event. As a consequence of tourism, invertebrates shift to outlying locations from the visited area, which serve as refuges to the communities. Apparently, the fact that there are places inside Lapa Nova inaccessible to tourists reduces the impact suffered by the invertebrate community, as those sites serve as refuges for cave-dwelling organisms during the pilgrimage. A proper management plan was devised for the tourism/religious use of the cave. It consists basically of delimiting marked pathways for tourists, allowing invertebrates to seek shelter at locations outside visited areas and keeping no-visitation areas off-limits to tourism based on the results of the visitation effects on cave-dwelling invertebrates.

Thais Giovannini Pellegrini; Rodrigo Lopes Ferreira

2012-01-01

145

Kepler Results  

Science.gov (United States)

We report on the progress of a project to confirm Kepler planet candidates in systems with multiple transiting planet candidates based on correlated transit timing variations (TTVs) among pairs of planet candidates in the same system. We provide an overview of putative TTV signals identified in the Kepler data set (Ford et al. 2011). We describe algorithms for assessing the statistical significance of correlated TTV signals and the results when applied to Kepler data. Kepler was selected as the 10th mission of the Discovery Program. Funding for this mission is provided by NASA, Science Mission Directorate.

Ford, Eric B.; Fabrycky, D.; Moorhead, A. V.; Rowe, J. F.; Steffen, J.; Kepler Science Team

2011-09-01

146

Combined Medication Shows Promise for Treating Cocaine Addiction  

Science.gov (United States)

... medication shows promise for treating cocaine addiction Combined medication shows promise for treating cocaine addiction Email Facebook ... for which there are no current FDA-approved medications. Buprenorphine is an opioid medication used for the ...

147

A case of cerebral infarction showing interesting SPECT images  

International Nuclear Information System (INIS)

[en] A case of cerebral infarction showing interesting SPECT images was reported. One month after stroke, 81mKr and 99mTc-HMPAO-SPECT were showed post ischemic high flow area as hot lesion, but 123I-IMP-SPECT was showed as cold lesion in early scan. Two months after stroke, all SPECT images showed infarction as cold area. (author)

1988-01-01

148

Non-asthmatic patients show increased exhaled nitric oxide concentrations  

Directory of Open Access Journals (Sweden)

Full Text Available OBJECTIVE: Evaluate whether exhaled nitric oxide may serve as a marker of intraoperative bronchospasm. INTRODUCTION: Intraoperative bronchospasm remains a challenging event during anesthesia. Previous studies in asthmatic patients suggest that exhaled nitric oxide may represent a noninvasive measure of airway inflammation. METHODS: A total of 146,358 anesthesia information forms, which were received during the period from 1999 to 2004, were reviewed. Bronchospasm was registered on 863 forms. From those, three groups were identified: 9 non-asthmatic patients (Bronchospasm group), 12 asthmatics (Asthma group) and 10 subjects with no previous airway disease or symptoms (Control group). All subjects were submitted to exhaled nitric oxide measurements (parts/billion), spirometry and the induced sputum test. The data was compared by ANOVA followed by the Tukey test and Kruskal-Wallis followed by Dunn's test. RESULTS: The normal lung function test results for the Bronchospasm group were different from those of the asthma group (p <0.05). The median percentage of eosinophils in induced sputum was higher for the Asthma [2.46 (0.45-6.83)] compared with either the Bronchospasm [0.55 (0-1.26)] or the Control group [0.0 (0)] (p <0.05); exhaled nitric oxide followed a similar pattern for the Asthma [81.55 (57.6-86.85)], Bronchospasm [46.2 (42.0 -62.6] and Control group [18.7 (16.0-24.7)] (p< 0.05). CONCLUSIONS: Non-asthmatic patients with intraoperative bronchospasm detected during anesthesia and endotracheal intubation showed increased expired nitric oxide.

Beatriz M. Saraiva-Romanholo; Fabio S. Machado; Francine M. Almeida; Maria do Patrocínio T. Nunes; Milton A. Martins; Joaquim E. Vieira

2009-01-01

149

Multilocus Phylogenetics Show High Intraspecific Variability within Fusarium avenaceum  

Directory of Open Access Journals (Sweden)

Full Text Available Fusarium avenaceum is a common soil saprophyte and plant pathogen of a variety of hosts worldwide. This pathogen is often involved in the crown rot and head blight of cereals that affects grain yield and quality. F. avenaceum contaminates grain with enniatins more than any species, and they are often detected at the highest prevalence among fusarial toxins in certain geographic areas. We studied intraspecific variability of F. avenaceum based on partial sequences of elongation factor-1 alpha, enniatin synthase, intergenic spacer of rDNA, arylamine N-acetyltransferase and RNA polymerase II data sets. The phylogenetic analyses incorporated a collection of 63 F. avenaceum isolates of various origin among which 41 were associated with wheat. Analyses of the multilocus sequence (MLS) data indicated a high level of genetic variation within the isolates studied with no significant linkage disequilibrium. Correspondingly, maximum parsimony analyses of both MLS and individual data sets showed lack of clear phylogenetic structure within F. avenaceum in relation to host (wheat) and geographic origin. Lack of host specialization indicates no host selective pressure in driving F. avenaceum evolution, while no geographic lineage structure indicates widespread distribution of genotypes that resulted in nullifying the effects of geographic isolation on the evolution of this species. Moreover, significant incongruence between all individual tree topologies and little clonality is consistent with frequent recombination within F. avenaceum.

Tomasz Kulik; Agnieszka Pszczó?kowska; Maciej ?ojko

2011-01-01

150

The use of computerized tomography in patients showing tardive dyskinesia  

International Nuclear Information System (INIS)

[en] 29 patients showing moderate to markedly pronounced tardive dyskinesia (TD) and a further 29 control patients (C) under a similar long-term medication with neuroleptics that had been so chosen as to match the age and sex distributions of the former group were subjected to computered tomography, neurological examination and psychological testing. The results did not point to any correlations between the structural changes and duration of treatment and the clinical signs or symptoms of extrapyramidal disorder. This was taken as further evidence in support of the theory that the initial damage in tardive dyskinesia mainly is at the level of the basal ganglia. (orig./MG)[de] 29 Patienten mit maessig bis schwer ausgepraegter Tardiver Dyskinesie (TD) und 29 alters- und geschlechtsgematchte Kontrollpatienten (C) mit vergleichbarer Langzeitneuroleptikabehandlung wurden computertomographisch, neurologisch und testpsychologisch untersucht. Es wurden keine Korrelationen zwischen strukturellen Veraenderungen und Therapiedauer und klinischem Bild der extrapyramidalen Symptomatik gefunden. Die Ergebnisse unterstuetzen die Hypothese, dass bei der Tardiven Dyskinesie Vorschaedigungen hauptsaechlich im Basalgangliensystem vorliegen. (orig./MG)

1983-01-01

151

Oilsands for the USA : while environmental groups ask for a shutdown, new study shows significant resulting economic benefits in America  

International Nuclear Information System (INIS)

The United States is beginning to appreciate the value of having massive oil sands resources located in relatively close proximity to their northern border. This article discussed a recent study conducted by the Canadian Energy Research Institute (CERI) to assess the impact of Canada's oil sands development on the economy of the United States. The study forecasted that the demand for oil sands-related goods and services from American companies will continue to increase as the industry expands. The top national-level goods and services impacts will be derived from increases in manufacturing; finance; insurance; real estate; and professional, scientific, and technical services. Accommodation and food services in the United States will also benefit from the growth of the oil sands industry. The United States may not risk pushing ahead with strict carbon-cutting legislation targeting the oil sands when policy-makers consider the potential impacts of Canada selling its resources to China. 1 fig.

2010-01-01

152

Survey results show that adults are willing to pay higher insurance premiums for generous coverage of specialty drugs.  

UK PubMed Central (United Kingdom)

Generous coverage of specialty drugs for cancer and other diseases may be valuable not only for sick patients currently using these drugs, but also for healthy people who recognize the potential need for them in the future. This study estimated how healthy people value insurance coverage of specialty drugs, defined as high-cost drugs that treat cancer and other serious health conditions like multiple sclerosis, by quantifying willingness to pay via a survey. US adults were estimated to be willing to pay an extra $12.94 on average in insurance premiums per month for generous specialty-drug coverage--in effect, $2.58 for every dollar in out-of-pocket costs that they would expect to pay with a less generous insurance plan. Given the value that people assign to generous coverage of specialty drugs, having high cost sharing on these drugs seemingly runs contrary to what people value in their health insurance.

Romley JA; Sanchez Y; Penrod JR; Goldman DP

2012-04-01

153

Landsat 7 Images Show Scale of Tsunami Damage  

Science.gov (United States)

This NASA page shows before and after pictures taken by Landsat 7's Enhanced Thematic Mapper Plus (ETM+) instrument of a part of the coast of Sumatra, Indonesia. The images show that the scale of the tsunami's impact can be seen from space.

Nasa

154

Reki-Show Authoring Tools : Risk, Space and History  

Directory of Open Access Journals (Sweden)

Full Text Available In social sciences, most events occur in specific time and space. We call such events here "Spatiotemporal Events". It is obvious that events, having always a beginning and an end, appear at a specific place or in particular space. Suppose there exists an conceptual data model regulating some rules to describe those factors, it enables us to store various spatiotemporal events as data and to refer with one another. We, therefore, define a simple spatiotemporal data model, calling "Reki-Show". We also call the information system, consisting of Reki-Show data model, "Reki-Show System", and consider Reki-Show System as the basic information system to deal with the various events in human society. Accordingly, we have recognized that it is indispensable in the future social sciences to have the database and tool for both the temporal and spatial attributes, and have been developing Reki-Show Authoring Tools based on the conceptual framework in Reki-Show System. At present, the fundamental component has been developed already through some steps, and the system is now applied to the empirical research. We would like to make a report of the outline at this stage. This paper explains the basic concept in Reki-Show (Conseptual Data Modeling), followed by the outline of the implemented system.

Makoto Hanashima; Ken-ichi Tomobe; Tsutomu Hirayama

2005-01-01

155

Nanoparticles Change Crystal Structure When They Get Wet, Research Shows  

Science.gov (United States)

... dlambert@nsf.gov Nanoparticles Change Crystal Structure When They Get Wet, Research Shows ... that "nanoparticles often had unexpected crystal structures and guessed it might be due to effects ...

156

Research Shows Cataract Surgery Can Reduce Hip Fracture Risk  

Science.gov (United States)

American Academy of Ophthalmology-sponsored Research Shows Cataract Surgery Can Reduce Hip Fracture Risk 08/01/2012 09:00:00 AM Medicare patient study finds significant health benefit in older patients SAN ...

157

3-D Images Show Flame Retardants Can Mimic Estrogens  

Science.gov (United States)

... Immediate Release: Monday, August 19, 2013 3-D images show flame retardants can mimic estrogens in NIH ... retardant TBBPA is shown, in this 3-D image, binding to the active site of an estrogen ...

158

Artificial Life Experiments Show How Complex Functions Can Evolve  

Science.gov (United States)

... 626) 395-3631 tindol@caltech.edu Artificial Life Experiments Show How Complex Functions Can Evolve ... computers, has used a kind of artificial life, or ALife, to create a road map detailing the ...

159

Housekeeping genes tend to show reduced upstream sequence conservation  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Mammalian housekeeping genes show significantly lower promoter sequence conservation, especially upstream of position -500 with respect to the transcription start site, than genes expressed in a subset of tissues.

Farré, Domènec; Bellora, Nicolás; Mularoni, Loris; Messeguer, Xavier; Albà, M Mar

160

??????????????---?????? Computer Simulation, a Nice Case —Now We Can Show  

Directory of Open Access Journals (Sweden)

Full Text Available ????????????????????????????????????????????????????????[1]????????????????????????????????????????????????“????”???This paper shows a case of computer simulation in China’s aerospace industry, which combines mathematics, physics, astronomy, electricity and manufacture[1]. This is a nice case and gives us some nice experiences for future.

???

2013-01-01

 
 
 
 
161

Gene-Based Blood Test for Colon Cancer Shows Promise  

Science.gov (United States)

... sharing features on this page, please enable JavaScript. Gene-Based Blood Test for Colon Cancer Shows Promise ... June 19, 2013 Related MedlinePlus Pages Colorectal Cancer Genes and Gene Therapy Laboratory Tests WEDNESDAY, June 19 ( ...

162

After-Transplant Problems That May Show Up Later  

Science.gov (United States)

... Next Topic Other issues related to transplants After-transplant problems that may show up later The type ... called Second Cancers Caused by Cancer Treatment . Post-transplant lymphoproliferative disorder Post-transplant lymphoproliferative ( lim -fo-pruh- ...

163

Tamoxifen's Mental Side Effects Are Real, Study Shows  

Science.gov (United States)

... sharing features on this page, please enable JavaScript. Tamoxifen's Mental Side Effects Are Real, Study Shows But ... Sept. 17 (HealthDay News) -- Some women who take tamoxifen to treat or prevent breast cancer report experiencing ...

164

Liver scan showing intense lung uptake in neoplasia and infection.  

UK PubMed Central (United Kingdom)

Two cases of intense lung activity uptake during routine liver imaging are presented. One patient died 6 days after uptake was seen, and had Kupffer cell tumor, or liver angiosarcoma, at autopsy. The second patient with an acute infection superimposed on alcholic hepatitis showed intense lung uptake on the tenth day of a sustained course of very high fever. A repeat liver scan after the patient became afebrile showed no lung uptake.

Imarisio JJ

1975-03-01

165

Optimizing the Natural Frequencies of Beams via Notch Stamping  

Directory of Open Access Journals (Sweden)

Full Text Available Natural frequency optimization is important to avoid the coincidence of excitation frequency and natural frequency which causes resonance phenomenon. In this study, the natural frequencies of a beam, with different boundary conditions, are enhanced by stamping V-notches on its surface. These notches alter the local stiffness in the beam while keeping the mass the same. This method is cost-effective in comparison with other Structural Dynamics Modification methods (SDM) because it is a one-step manufacturing method and because it enhances the dynamic behavior of beam structures without additional weight or additional joints. The natural frequencies of notched beam are calculated by finite element method. In particular, ANSYS package is used in building the notched beam models for modal analysis. The effect of notch location and size on the beam fundamental frequency is investigated. The simulation results indicated that creating notches on free-free beam decreases its fundamental frequency, while creating notches on clamped beam may increase its fundamental frequency. The optimal designs of notched beams are presented. The proposed method couples a finite element method for the modal analysis with an optimization technique based on Genetic Algorithm (GA). Three examples are presented to show the optimal design of free-free and clamped notched beams. The optimization results show that V-notch stamping technique is an effective technique to optimize the natural frequencies.

Nabeel T. Alshabatat

2012-01-01

166

The Effectiveness of Trade Shows in Global Competition  

Directory of Open Access Journals (Sweden)

Full Text Available Trade shows industry has experienced a rapid growth during the last years. They are considered as a vital communication technique especially for those companies that operate in international markets and that aim to reach specific audiences. Making them an integral part of the marketing communication strategy enables companies in: developing customer relationships; offering possibilities for sales and sales promotion; undertaking and maintaining good international business relations; monitoring international competition as well as minimizing entry barriers in new markets. During the last years, many Albanian companies that operate in foreign businesses have started to engage in trade shows. Face to face meetings with their potential customers and direct competitors are among the most important reasons for investing in this marketing tool. Even though the literature regarding trade shows effectiveness is increasing constantly, research on its effectiveness is still limited. Therefore, the aim of this paper is to study the effectiveness of trade shows as a marketing communication tool. More specifically, it is focused in studying the usage of trade shows by Albanian companies when competing on international markets.

JONIDA KELLEZI

2013-01-01

167

An induced sterile mutant in black gram (Vigna mungo L.) showing failure of chromosome pairing  

International Nuclear Information System (INIS)

In a M2 progeny row of black gram var. T9, resulting from irradiation treatment, a plant was recorded which showed considerable univalent formation. The M2 progeny confirmed its generic nature, showing its possible monogenetic control. (auth.).

1978-01-01

168

The presentation of science in everyday life: the science show  

Science.gov (United States)

This paper constitutes a case-study of the `science show' model of public engagement employed by a company of science communicators focused on the popularization of science, technology, engineering and mathematics (STEM) subject disciplines with learner constituencies. It examines the potential of the science show to foster the interest and imagination of young learners in STEM; challenge popular pre/misconceptions of science and scientists; reveal the broadness, plurality and everyday relevance of science; and induce a more fluent and equitable science nexus between expert and non-expert or learner groups. Discussion focuses on conversations with members of a UK and university based science communication outfit who comment on the potential of the science show as a model of non-formal science education and science engagement and the necessary conditions for its success.

Watermeyer, Richard

2013-09-01

169

Uni Dufour | Ig Nobel Show with Marc Abrahams | 7 May  

CERN Multimedia

On 7 May, Marc Abrahams, founder of the Ig Nobel Prize, will give an "Ig Nobel show", in English at Uni Dufour. The Ig Nobel Prizes are an American parody of the Nobel Prizes. In early October of each year, they are awarded to ten unusual or trivial achievements in scientific research. The stated aim of the prizes is to "first make people laugh, and then make them think". Marc Abrahams will introduce this funny and dynamic evening with a short presentation before handing over to a selection of recipients. The show is free and open to all. Tuesday 7 May Ig Nobel Show 6:30 p.m. - Room U600 Uni Dufour

2013-01-01

170

Five Kepler target stars that show multiple transiting exoplanet candidates  

CERN Document Server

We present and discuss five candidate exoplanetary systems identified with the Kepler spacecraft. These five systems show transits from multiple exoplanet candidates. Should these objects prove to be planetary in nature, then these five systems open new opportunities for the field of exoplanets and provide new insights into the formation and dynamical evolution of planetary systems. We discuss the methods used to identify multiple transiting objects from the Kepler photometry as well as the false-positive rejection methods that have been applied to these data. One system shows transits from three distinct objects while the remaining four systems show transits from two objects. Three systems have planet candidates that are near mean motion commensurabilities - two near 2:1 and one just outside 5:2. We discuss the implications that multitransiting systems have on the distribution of orbital inclinations in planetary systems, and hence their dynamical histories; as well as their likely masses and chemical compos...

Steffen, Jason H; Borucki, William J; Buchhave, Lars A; Caldwell, Douglas A; Cochran, William D; Endl, Michael; Fabrycky, Daniel C; Fressin, François; Ford, Eric B; Fortney, Jonathan J; Haas, Michael J; Holman, Matthew J; Isaacson, Howard; Jenkins, Jon M; Koch, David; Latham, David W; Lissauer, Jack J; Moorhead, Althea V; Morehead, Robert C; Marcy, Geoffrey; MacQueen, Phillip J; Quinn, Samuel N; Ragozzine, Darin; Rowe, Jason F; Sasselov, Dimitar D; Seager, Sara; Torres, Guillermo; Welsh, William F

2010-01-01

171

CERN cars drive by the Geneva Motor Show  

CERN Document Server

One of CERN's new gas-fuelled cars was a special guest at the press days of the Geneva motor show this year. The car enjoyed a prominent position on the Gazmobil stand, right next to the latest Mazeratis and Ferraris. Journalists previewing the motor show could discover CERN's support for green technologies and also find out more about the lab - home to the fastest racetrack on the planet, with protons in the LHC running at 99.9999991% of the speed of light.    

CERN Bulletin

2011-01-01

172

Gigantiform cementoma showing apparent activity on a bone scan.  

UK PubMed Central (United Kingdom)

A bone scan in a Negroid female suspected of myeloma showed no uptake other than in the jaws. A panoramic radiograph revealed multiple mixed-density lesions, in particular in the mandible, suggestive of gigantiform cementoma. The significance of this association is discussed.

Millet DT

1990-08-01

173

Discrete Dynamical Models Showing Pattern Formation in Subaqueous Bedforms  

CERN Document Server

Abstract: A new class of ``toy models'' for subaqueous bedform formation are proposed and examined. These models all show a similar mechanism of wavelength selection via bedform unification, and they may have applications to bedform stratigraphy. The models are also useful for exploring general issues of pattern formation and complexity in stochastically driven far from equilibrium systems.

Tufillaro, N B

1993-01-01

174

KGB- agents (Part 2: Music and show -bussines)  

Science.gov (United States)

The paper represents a continuation of the previous one 2008stuk.rept.....G and reffers to activity of KGB in the Show Busyness in the former USSR. During 1970-th the activity of KGB was concerned to control the market of musical disks, the disco clubs, the programs and the personal componence of the musical groups and orchestra.

Gaina, Alex

2008-10-01

175

Going through the 33rd Tokyo Motor Show. Passenger cars and motorcycles show in the last 20th century; Dai 33 kai Tokyo Motor Show kenbunki. 20 seiki saigono joyosha nirinsha show ga miseta mono  

Energy Technology Data Exchange (ETDEWEB)

This paper summarizes what has been seen and heard at the 33rd Motor Show held in the city of Chiba in October 1999. The Show has become a show dedicated to passenger cars and motorcycles. Exhibitors included six governments, one organization and 287 companies from 15 countries. Designs were better in European and American cars than in Japanese cars. Attitudes of tackling with direct gasoline injection systems were seen in the Japanese makers, as well as in European car makers who are indicated of the same movement. Further low fuel consumption is in progress by combining the direct gasoline injection with controls and power trains. Another one that has been highlighted was the bybrids. Development of high-performance batteries has also been advanced, where a conception was born that a car is an energy reservoir. Every maker has announced power units using fuel cells. These cars have undecided issues such as how to prepare hydrogen, making when a car runs on road unpredictable. Having announced many light-weight cars made of aluminum was another feature of this year's show. Exhibition was made on technologies to make small motorcycles less polluting and less fuel consuming. A small bike mounted with a home use gas bomb was a unique appearance. (NEDO)

Mihori, N.

2000-01-01

176

An autopsied case of tuberculous meningitis showing interesting CT findings  

International Nuclear Information System (INIS)

[en] A 61-year-old female patient died of a neurological disorder of unknown origin one month after the first visit and was found to have had tuberculous meningitis at autopsy. CT revealed a low density area showing an enlargement of the cerebral ventricle but did not reveal contrast enhancement in the basal cistern peculiar to tuberculous meningitis. (Namekawa, K.)

1983-01-01

177

Autopsied case of tuberculous meningitis showing interesting CT findings  

Energy Technology Data Exchange (ETDEWEB)

A 61-year-old female patient died of a neurological disorder of unknown origin one month after the first visit and was found to have had tuberculous meningitis at autopsy. CT revealed a low density area showing an enlargement of the cerebral ventricle but did not reveal contrast enhancement in the basal cistern peculiar to tuberculous meningitis.

Abiko, Takashi; Higuchi, Hiroshi; Imada, Ryuichi; Nagai, Kenichi (Iwate Prefectural Central Hospital (Japan))

1983-11-01

178

Assessment of the effects of neutron fluence on Swedish nuclear pressure vessels  

International Nuclear Information System (INIS)

[en] Nuclear pressure vessels are subject to neutron irradiation during service causing embrittlement. At present the irradiation effects are mainly assessed by the Charpy V-notch test. Two measures of embrittlement are defined: the increase of the ductile/brittle transition temperature and the decrease in the upper-shelf energy. The object of the present work is to assess these changes for the Swedish nuclear pressure vessels. On the basis of data from irradiations carried out in other countries and Swedish surveillance programmes, the expected end of life embrittlement is estimated for Swedish vessels. The results show that the embrittlement of most reactor vessels is expected to be quite small. Oskarshamn 1 and PWR-vessels, however, will probably show moderate changes, the former due to the higher copper content, and the latter due to the high end of life fluences. Some of the vessel materials which exhibit marginal properties in the upper-shelf energy, as measured by the Charpy V-notch impact test, are identified. It is recommended that fracture mechanics analyses be applied in these cases. (author)

1980-01-01

179

New Inspiring Planetarium Show Introduces ALMA to the Public  

Science.gov (United States)

As part of a wide range of education and public outreach activities for the International Year of Astronomy 2009 (IYA2009), ESO, together with the Association of French Language Planetariums (APLF), has produced a 30-minute planetarium show, In Search of our Cosmic Origins. It is centred on the global ground-based astronomical Atacama Large Millimeter/submillimeter Array (ALMA) project and represents a unique chance for planetariums to be associated with the IYA2009. ESO PR Photo 09a/09 Logo of the ALMA Planetarium Show ESO PR Photo 09b/09 Galileo's first observations with a telescope ESO PR Photo 09c/09 The ALMA Observatory ESO PR Photo 09d/09 The Milky Way band ESO PR Video 09a/09 Trailer in English ALMA is the leading telescope for observing the cool Universe -- the relic radiation of the Big Bang, and the molecular gas and dust that constitute the building blocks of stars, planetary systems, galaxies and life itself. It is currently being built in the extremely arid environment of the Chajnantor plateau, at 5000 metres altitude in the Chilean Andes, and will start scientific observations around 2011. ALMA, the largest current astronomical project, is a revolutionary telescope, comprising a state-of-the-art array of 66 giant 12-metre and 7-metre diameter antennas observing at millimetre and submillimetre wavelengths. In Search of our Cosmic Origins highlights the unprecedented window on the Universe that this facility will open for astronomers. "The show gives viewers a fascinating tour of the highest observatory on Earth, and takes them from there out into our Milky Way, and beyond," says Douglas Pierce-Price, the ALMA Public Information Officer at ESO. Edited by world fulldome experts Mirage3D, the emphasis of the new planetarium show is on the incomparable scientific adventure of the ALMA project. A young female astronomer guides the audience through a story that includes unique animations and footage, leading the viewer from the first observations by Galileo, 400 years ago, to the world of modern astronomy, moving from the visible wavelength domain to explore the millimetre-wave view of the Universe, and leaving light-polluted cities for unique settings in some of the highest and driest places on Earth. "The fascinating topic, the breathtaking ESO astronomical images, the amazing 3D computer animations, and the very clever use of the music, all make this a really inspiring show," says Agnès Acker, President of the APLF. In search of our Cosmic Origins is available in three different formats: fulldome video, classical with video windows, and classical with slides. Fulldome video shows immerse the audience in a true 360-degree projected computer-generated virtual environment. The ALMA planetarium show is currently available in French and English. Several other language versions are in preparation: German, Italian, Spanish and Chilean Spanish, while further languages are planned: Danish, Dutch, Greek, Japanese, Portuguese and Brazilian Portuguese. The show will be available to all planetariums worldwide for a small fee, depending on the type and the size of the planetarium, to cover basic costs. The media are invited to attend, and see firsthand, the official screening during the European Film Festival, between 24 and 26 April 2009 in Espinho, Portugal. For media accreditation, please go to http://iff.multimeios.pt/index.php?option=com_wrapper&Itemid=45 A set of educational materials is also being prepared and will be finished in late April. To learn more about the show, please go to www.cosmicorigins.org

2009-03-01

180

Cambrian stalked echinoderms show unexpected plasticity of arm construction.  

UK PubMed Central (United Kingdom)

Feeding arms carrying coelomic extensions of the theca are thought to be unique to crinoids among stemmed echinoderms. However, a new two-armed echinoderm from the earliest Middle Cambrian of Spain displays a highly unexpected morphology. X-ray microtomographic analysis of its arms shows they are polyplated in their proximal part with a dorsal series of uniserial elements enclosing a large coelomic lumen. Distally, the arm transforms into the more standard biserial structure of a blastozoan brachiole. Phylogenetic analysis demonstrates that this taxon lies basal to rhombiferans as sister-group to pleurocystitid and glyptocystitid blastozoans, drawing those clades deep into the Cambrian. We demonstrate that Cambrian echinoderms show surprising variability in the way their appendages are constructed, and that the appendages of at least some blastozoans arose as direct outgrowths of the body in much the same way as the arms of crinoids.

Zamora S; Smith AB

2012-01-01

 
 
 
 
181

Cambrian stalked echinoderms show unexpected plasticity of arm construction.  

Science.gov (United States)

Feeding arms carrying coelomic extensions of the theca are thought to be unique to crinoids among stemmed echinoderms. However, a new two-armed echinoderm from the earliest Middle Cambrian of Spain displays a highly unexpected morphology. X-ray microtomographic analysis of its arms shows they are polyplated in their proximal part with a dorsal series of uniserial elements enclosing a large coelomic lumen. Distally, the arm transforms into the more standard biserial structure of a blastozoan brachiole. Phylogenetic analysis demonstrates that this taxon lies basal to rhombiferans as sister-group to pleurocystitid and glyptocystitid blastozoans, drawing those clades deep into the Cambrian. We demonstrate that Cambrian echinoderms show surprising variability in the way their appendages are constructed, and that the appendages of at least some blastozoans arose as direct outgrowths of the body in much the same way as the arms of crinoids. PMID:21653588

Zamora, S; Smith, A B

2011-06-08

182

Study shows `abysmal performance` of Australian black coal  

Energy Technology Data Exchange (ETDEWEB)

A comprehensive benchmark study shows that Australian black coal open cut mines perform significantly worse than Australian hard rock mines and comparable US coal mines. Conducted by Tasman Asia Pacific, the study, entitled `The cope for productivity improvement in Australia`s open cut black coal industry`, shows how poor labour productivity in New South Wales especially is a crippling limitation on coal mining in that state. Queensland`s performance, whilst better than that of NSW, is well below that of Australian hard rock mines and US coal mines. Truck and shovel operations in New South Wales and Queensland need to improve productivity, and New South Wales needs to increase productivity of dragline operations. 3 figs.

NONE

1997-10-01

183

Salomon Bros. survey shows flat upstream spending for 1992  

International Nuclear Information System (INIS)

[en] The yearly survey by Salomon Bros., New York of upstream spending by the international petroleum industry shows little change for 1992 from 1991. This paper reports that a substantial shift from U.S. to non U.S. exploration and production will continue, the firm's 10th and largest survey-241 companies-shows only 1 1.3% increase in worldwide exploration and production spending to $53.7 billion in 1992 from $53.1 billion estimated in 1991. The amount estimated for last year's spending is less than the sum forecast at midyear 1991. That, in turn, is lower than what was budgeted for 1991 in December 1990. Budgets in 1991 were significantly underspent in the U.S. and Canada but not elsewhere

1992-01-27

184

Salomon Bros. survey shows flat upstream spending for 1992  

Energy Technology Data Exchange (ETDEWEB)

The yearly survey by Salomon Bros., New York of upstream spending by the international petroleum industry shows little change for 1992 from 1991. This paper reports that a substantial shift from U.S. to non U.S. exploration and production will continue, the firm's 10th and largest survey-241 companies-shows only 1 1.3% increase in worldwide exploration and production spending to $53.7 billion in 1992 from $53.1 billion estimated in 1991. The amount estimated for last year's spending is less than the sum forecast at midyear 1991. That, in turn, is lower than what was budgeted for 1991 in December 1990. Budgets in 1991 were significantly underspent in the U.S. and Canada but not elsewhere.

1992-01-27

185

Evaluation of the ductile-to-brittle transition temperature shift due to temper embrittlement and neutron irradiation by means of a small-punch test  

International Nuclear Information System (INIS)

[en] By means of a small-punch testing technique, the effects of heterogeneous intergranular impurity segregation and neutron irradiation on the ductile-to-brittle transition temperature (DBTT) of impurity-doped and undoped alloy steels were investigated. It was found that antimony-doped steels and, in particular, non-homogenized steels with extremely heterogeneous intergranular dopant segregation frequently show initiation of microcracks as indicated by the appearance of serrations in the load-deflection curves. In this case the ductile to brittle transition is spread out over a wider temperature range than for tin- or phosphorus-doped steels as well as for undoped steel. The upper and lower bounds of the DBTT are uniquely correlated with the maximum and average values of the impurity segregation concentration distributed along grain boundaries. These relationships demonstrate the embrittling potency of the segregants, in agreement with results obtained from Charpy V-notch tests. Neutron irradiation of tin-doped steels caused the DBTT to shift to higher temperatures than that of undoped steels. The experimental results suggest a linear correlation between the DBTTs obtained from small-punch tests and those obtained from Charpy V-notch tests, as predicted by a recently developed kinetic model. (orig.)

1986-01-01

186

Isolation of mitochondria from Plasmodium falciparum showing dihydroorotate dependent respiration.  

UK PubMed Central (United Kingdom)

Using N2 cavitation, we established a protocol to prepare the active mitochondria from Plasmodium falciparum showing a higher succinate dehydrogenase activity than previously reported and a dihydroorotate-dependent respiration. The fact that fumarate partially inhibited the dihydroorotate dependent respiration suggests that complex II (succinate-ubiquinone reductase/quinol-fumarate reductase) in the erythrocytic stage cells of P. falciparum functions as a quinol-fumarate reductase.

Takashima E; Takamiya S; Takeo S; Mi-ichi F; Amino H; Kita K

2001-11-01

187

Study shows greater potential for high pressure showers  

Energy Technology Data Exchange (ETDEWEB)

The need for cleaning felts has increased because more secondary fibre is being used, felts are lasting longer and closed systems are more common in PMs. High pressure showers are used by a lot of mills - but not to the best effect. A study by Nordiskafilt of Sweden shows, that if the HPS is used efficiently, mills can improve the cleaning process, prolong felt life and cut water and energy consumption.

Olsson, J.L.

1986-02-01

188

PC code STAR. Show transmutation of actinides in reactors  

Energy Technology Data Exchange (ETDEWEB)

A program is made named STAR (acronym for Show Transmutation of Actinides in Reactors), which solves analytically the differential equations describing buildup and removal (by decay and transmutation) of nuclides irradiated in a constant neutron flux. The model and algorithm according to which STAR solves the differential equations are explained. Also a short description of the data library is given. STAR is validated with the ORIGEN-S fuel depletion code and runs on IBM compatible PCs and DEC alpha workstations. (orig.).

Oppe, J.; Kloosterman, J.L.

1995-02-01

189

La televisión, en su función normativa. El reality show  

Directory of Open Access Journals (Sweden)

Full Text Available En principio puede resultar extraño el plantear un texto televisivo como el Reality Show como un texto que posea una función normativa. Planteamos esta posibilidad después de analizar detenidamente varios de estos programas, por lo tanto esta reflexión surge, por una parte, del análisis de un objeto empírico, el programa televisivo, y por otra de la teorización realizada por Pierre Bourdieu sobre los comportamientos sociales en la vida cotidiana.

Lic. Roberto Arnau Díez

2000-01-01

190

A duplex kidney with dromedary hump showing altered hilar anatomy  

Directory of Open Access Journals (Sweden)

Full Text Available A comprehensive knowledge of the wide range of variations of renal vasculature and renal pelvis is mandatory to the anatomists for a better understanding of the embryology. It remains as the key issue in determining the technical feasibility of various endourologic procedures and innumerable intervention techniques besides kidney retrievals for transplantation. In the present case the duplex kidney showed lobulations on the anterior surface just adjacent to the hilar region. The midlateral portion of the convex lateral border of the kidney showed a small focal bulge –dromedary hump. At the hilum reversed anterio-posterior disposition of renal vasculature with anteriorly placed renal artery which bifurcated into two upper and lower anterior segmental branches. The renal vein formed by large tributaries arising from the hilum running towards the inferior vena cava. The renal pelvis was most posteriorly placed which showed a double pelvis. The upper pelvis was seen arising behind the renal vein and the lower pelvis arising inferomedial to the lower anterior segmental artery.Both the pelvises were seen uniting medial to the lower part of hilum and continued as a single ureter which opened into the bladder. The thorough knowledge of these anatomical variations is necessary to avoid iatrogenic injuries and enable the surgeon and radiologists approach unusual situations with confidence rather than surprise.

Tallapaneni S; Vemavarapu M

2011-01-01

191

Five Kepler target stars that show multiple transiting exoplanet candidates  

Energy Technology Data Exchange (ETDEWEB)

We present and discuss five candidate exoplanetary systems identified with the Kepler spacecraft. These five systems show transits from multiple exoplanet candidates. Should these objects prove to be planetary in nature, then these five systems open new opportunities for the field of exoplanets and provide new insights into the formation and dynamical evolution of planetary systems. We discuss the methods used to identify multiple transiting objects from the Kepler photometry as well as the false-positive rejection methods that have been applied to these data. One system shows transits from three distinct objects while the remaining four systems show transits from two objects. Three systems have planet candidates that are near mean motion commensurabilities - two near 2:1 and one just outside 5:2. We discuss the implications that multitransiting systems have on the distribution of orbital inclinations in planetary systems, and hence their dynamical histories; as well as their likely masses and chemical compositions. A Monte Carlo study indicates that, with additional data, most of these systems should exhibit detectable transit timing variations (TTV) due to gravitational interactions - though none are apparent in these data. We also discuss new challenges that arise in TTV analyses due to the presence of more than two planets in a system.

Steffen, Jason H.; /Fermilab; Batalha, Natalie M.; /San Jose State U.; Borucki, William J.; /NASA, Ames; Buchhave, Lars A.; /Harvard-Smithsonian Ctr. Astrophys. /Bohr Inst.; Caldwell, Douglas A.; /NASA, Ames /SETI Inst., Mtn. View; Cochran, William D.; /Texas U.; Endl, Michael; /Texas U.; Fabrycky, Daniel C.; /Harvard-Smithsonian Ctr. Astrophys.; Fressin, Francois; /Harvard-Smithsonian Ctr. Astrophys.; Ford, Eric B.; /Florida U.; Fortney, Jonathan J.; /UC, Santa Cruz, Phys. Dept. /NASA, Ames

2010-06-01

192

Five kepler target stars that show multiple transiting exoplanet candidates  

DEFF Research Database (Denmark)

We present and discuss five candidate exoplanetary systems identified with the Kepler spacecraft. These five systems show transits from multiple exoplanet candidates. Should these objects prove to be planetary in nature, then these five systems open new opportunities for the field of exoplanets and provide new insights into the formation and dynamical evolution of planetary systems. We discuss the methods used to identify multiple transiting objects from the Kepler photometry as well as the false-positive rejection methods that have been applied to these data. One system shows transits from three distinct objects while the remaining four systems show transits from two objects. Three systems have planet candidates that are near mean motion commensurabilities—two near 2:1 and one just outside 5:2. We discuss the implications that multi-transiting systems have on the distribution of orbital inclinations in planetary systems, and hence their dynamical histories, as well as their likely masses and chemical compositions. A Monte Carlo study indicates that, with additional data, most of these systems should exhibit detectable transit timing variations (TTVs) due to gravitational interactions, though none are apparent in these data. We also discuss new challenges that arise in TTV analyses due to the presence of more than two planets in a system.

Steffen..[], Jason H.; Batalha, N. M.

2010-01-01

193

Electricity show and related educational programming. Final report  

Energy Technology Data Exchange (ETDEWEB)

The on-site version of Balance of Power reached a total audience of 21,331 between November 10, 1994 and January 31, 1996; in addition, the Physics on Wheels van offered exhibits and programs to an additional 30,000 students in the 1995-1996 school year. The program provided a groundbreaking new approach to informal science education, combining a dynamic demonstration with an intensely interactive game show. Between the on-site programming and the Physics on Wheels van programs, 51,331 students were impacted by the activities, exhibits and energy-conservation message of Balance of Power.

NONE

1997-03-19

194

Strobes: pyrotechnic compositions that show a curious oscillatory combustion.  

UK PubMed Central (United Kingdom)

Strobes are pyrotechnic compositions which show an oscillatory combustion; a dark phase and a flash phase alternate periodically. The strobe effect has applications in various fields, most notably in the fireworks industry and in the military area. All strobe compositions mentioned in the literature were discovered by trial and error methods and the mechanisms involved remain unclear. Many oscillatory systems such as Belousov-Zhabotinsky reactions, cool flames, self-propagating high-temperature synthesis have been observed and theories developed to elucidate their unstable behavior based on chemical interactions or based on physical processes. These systems are compared to experimental observations made on strobe mixtures.

Corbel JM; van Lingen JN; Zevenbergen JF; Gijzeman OL; Meijerink A

2013-01-01

195

[Three cases of subacute panencephalitis showing asterexis-like movements  

UK PubMed Central (United Kingdom)

We reported 3 cases with subacute sclerosing panencephalitis (SSPE) showing recurrent and involuntary motor phenomena. Their electroclinical correlates were analyzed using CCTV-EEG. Clinically, they slanted their trunks and/or heads, and dropped their upper limbs momentarily only when their antigravity muscles were suitably contracting (sitting, standing, or stretching out their arms). Electrographically, the motor phenomena corresponded with the occurrence of periodic synchronous discharges (PSD) (in one-to-one manner). EMG potentials associated with the muscle contraction subsided at the very moment. These motor phenomena observed in patients with SSPE were discussed in relation to asterexis.

Watanabe M; Fujiwara T; Nakamura H; Morikawa T; Yagi K; Seino M

1991-01-01

196

DIY identity kit: the Great American Lesbian Art Show.  

Science.gov (United States)

The Great American Lesbian Art Show, which opened at the Woman's Building in Los Angeles in May 1980, was conceived to increase visibility for lesbian artists, and to forge bonds among lesbians across the United States. It comprised a curated Invitational of ten artists and scores of regional GALAS events mounted simultaneously by women from Boston to Honolulu. The art on view, documented in a slide archive, staged a critique of contemporary gender norms. Participating artists represented lesbian identities that claimed universality while they reflected the artists' particularized experience of woman-identification and sexual desire. PMID:20408014

Thompson, Margo Hobbs

2010-01-01

197

DIY identity kit: the Great American Lesbian Art Show.  

UK PubMed Central (United Kingdom)

The Great American Lesbian Art Show, which opened at the Woman's Building in Los Angeles in May 1980, was conceived to increase visibility for lesbian artists, and to forge bonds among lesbians across the United States. It comprised a curated Invitational of ten artists and scores of regional GALAS events mounted simultaneously by women from Boston to Honolulu. The art on view, documented in a slide archive, staged a critique of contemporary gender norms. Participating artists represented lesbian identities that claimed universality while they reflected the artists' particularized experience of woman-identification and sexual desire.

Thompson MH

2010-01-01

198

Pseudo Random Coins Show More Heads Than Tails  

CERN Multimedia

Tossing a coin is the most elementary Monte Carlo experiment. In a computer the coin is replaced by a pseudo random number generator. It can be shown analytically and by exact enumerations that popular random number generators are not capable of imitating a fair coin: pseudo random coins show more heads than tails. This bias explains the empirically observed failure of some random number generators in random walk experiments. It can be traced down to the special role of the value zero in the algebra of finite fields.

Bauke, H; Bauke, Heiko; Mertens, Stephan

2003-01-01

199

[A case of achondroplasia showing diffuse spinal canal stenosis].  

Science.gov (United States)

A rare case of achondroplasia showing diffuse spinal canal stenosis is presented. A 39-year-old woman was admitted to our hospital because of numbness of lower extremities and intermittent claudication. The patient's height was 121cm and she had the typical clinical features of an achondroplastic dwarf. Neurological examination revealed spastic paraparesis, and sensory impairment below the level of T11 in the left side and L1 in the right. A plain X-ray feature of the spine showed spinal canal stenosis. The interpedicular distances were short in all vertebrae, and especially more prominent in the caudal lumbar region. The sacrum laid horizontally and the sacral angle was narrower than normal case. Myelography and computed tomographic myelography demonstrated severe stenosis of the subarachnoid space at the level of T9-11. Laminectomy was performed from the inferior half of T9 to T11. The yellow ligaments were prominently hypertrophic and these were removed as far as possible. Postoperatively, the weakness of the lower extremities was improved immediately, but numbness remained. Five months after the operation, she suffered from urinary dysfunction, so further laminectomy from T12 to L5 was performed. Also in this operation, hypertrophic yellow ligament was pathognomonic. Following this operation the patient had a good recovery course and returned to work. PMID:2215874

Ohashi, T; Morimoto, T; Sakaki, T; Kyoi, K; Utsumi, S; Yonezawa, Y; Fujita, T

1990-08-01

200

[A case of achondroplasia showing diffuse spinal canal stenosis  

UK PubMed Central (United Kingdom)

A rare case of achondroplasia showing diffuse spinal canal stenosis is presented. A 39-year-old woman was admitted to our hospital because of numbness of lower extremities and intermittent claudication. The patient's height was 121cm and she had the typical clinical features of an achondroplastic dwarf. Neurological examination revealed spastic paraparesis, and sensory impairment below the level of T11 in the left side and L1 in the right. A plain X-ray feature of the spine showed spinal canal stenosis. The interpedicular distances were short in all vertebrae, and especially more prominent in the caudal lumbar region. The sacrum laid horizontally and the sacral angle was narrower than normal case. Myelography and computed tomographic myelography demonstrated severe stenosis of the subarachnoid space at the level of T9-11. Laminectomy was performed from the inferior half of T9 to T11. The yellow ligaments were prominently hypertrophic and these were removed as far as possible. Postoperatively, the weakness of the lower extremities was improved immediately, but numbness remained. Five months after the operation, she suffered from urinary dysfunction, so further laminectomy from T12 to L5 was performed. Also in this operation, hypertrophic yellow ligament was pathognomonic. Following this operation the patient had a good recovery course and returned to work.

Ohashi T; Morimoto T; Sakaki T; Kyoi K; Utsumi S; Yonezawa Y; Fujita T

1990-08-01

 
 
 
 
201

VTA neurons show a potentially protective transcriptional response to MPTP.  

UK PubMed Central (United Kingdom)

Parkinson's disease and its characteristic symptoms are thought to arise from the progressive degeneration of specific midbrain dopamine (DA) neurons. In humans, DA neurons of the substantia nigra (SN) and their projections to the striatum show selective vulnerability, while neighboring DA neurons of the ventral tegmental area (VTA) are relatively spared from degeneration. This pattern of cell loss is mimicked in humans, primates, and certain rodents by the neurotoxin MPTP. In this study, we aimed to test the hypothesis that there are factors in the VTA that are potentially neuroprotective against MPTP and that these factors change over time. We have found a dynamic transcriptional response within the cells of the VTA to sustained exposure to a low dose of MPTP. Specifically, the VTA has increased expression of 148 genes as an early response to MPTP and 113 genes as a late response to MPTP toxicity. This response encompasses many areas of cellular function, including protein regulation (Phf6) and ion/metal regulation (PANK2 and Car4). Notably, these responses were largely absent from the cells of the SN. Our data show a clear dynamic response in maintaining the homeostasis and viability of the neurons in the VTA that is lacking in the SN after neurotoxin challenge.

Phani S; Gonye G; Iacovitti L

2010-07-01

202

Monkeys show recognition without priming in a classification task.  

UK PubMed Central (United Kingdom)

Humans show visual perceptual priming by identifying degraded images faster and more accurately if they have seen the original images, while simultaneously failing to recognize the same images. Such priming is commonly thought, with little evidence, to be widely distributed phylogenetically. Following Brodbeck (1997), we trained rhesus monkeys (Macaca mulatta) to categorize photographs according to content (e.g., birds, fish, flowers, people). In probe trials, we tested whether monkeys were faster or more accurate at categorizing degraded versions of previously seen images (primed) than degraded versions of novel images (unprimed). Monkeys categorized reliably, but showed no benefit from having previously seen the images. This finding was robust across manipulations of image quality (color, grayscale, line drawings), type of image degradation (occlusion, blurring), levels of processing, and number of repetitions of the prime. By contrast, in probe matching-to-sample trials, monkeys recognized the primes, demonstrating that they remembered the primes and could discriminate them from other images in the same category under the conditions used to test for priming. Two experiments that replicated Brodbeck's (1997) procedures also produced no evidence of priming. This inability to find priming in monkeys under perceptual conditions sufficient for recognition presents a puzzle.

Basile BM; Hampton RR

2013-02-01

203

Static and impact crack properties of a high-strength steel welded joint  

International Nuclear Information System (INIS)

In order to gain the benefits of weldable high-strength steels in pressurized equipment applications, satisfactory toughness and crack properties of the welded joint, both in the weld metal and the heat-affected -zone (HAZ), are required. Experimental investigations of toughness and crack resistance parameters through static and impact tests of a high-strength, low-alloy steel (HSLA) with a nominal yield strength of 700 MPa and its welded joint, were performed on Charpy-sized specimens, V-notched and pre-cracked, of the parent metal, weld metal and HAZ. The selected electrode produced slight undermatching and enabled the welded joints to be manufactured without cold cracks. The impact energy and its parts responsible for crack initiation and propagation were determined by toughness evaluation. Crack sensitivity, defined as the ratio of the impact energy for V-notched and for pre-cracked specimens, enabled a comparison of the homogeneous microstructure of the parent metal and the weld metal, and of the heterogeneous microstructure of the heat-affected-zone (HAZ), which indicated a better crack toughness behaviour of the HAZ. The results obtained showed that the toughness and crack resistance of the weld metal were significantly lower than those of the parent metal and the HAZ. The fracture mechanics parameters, J Ic integral, and plane strain fracture toughness, K Ic, as well as J resistance curves expressed the degradation less.

2007-01-01

204

La Realidad Simulada. Una Crítica del reality show The simmulation of Reality. A critic of the reality show.  

Directory of Open Access Journals (Sweden)

Full Text Available El reality show es el formato televisivo más exitoso de los últimos años. Este artículo efectúa una exploración en torno a dicho formato articulada en tres partes. Primero, se estudiará la tensión que los realities generan entre la representación como esquema estético tradicional y la simulación como esquema estético emergente; luego, se detallará la manera en que los realities participan en la producción del mundo como imagen; finalmente, se explicará el papel que los realities cumplen en el marco de la economía estética contemporánea y se ofrecerá una explicación sociopsicológica de su poder de seducción. El artículo en su conjunto aborda el estudio del reality a través del lente amplio de una crítica de la industria del entretenimiento.Reality shows are one of the most successful television genres in the last few years. The exploration that this article will make around this genre consists of three parts. First, the tension that realities cause between representation as a traditional aesthetic style and simulation as an emergent aesthetic style will be examined. Second, the way realities participate in the construction of the world as image will be described. Finally, the article will explain the role that realities play in the contemporary aesthetic economy, and offer a socio-psychological explanation of its seductive power. The article approaches the study of reality shows by taking a critical perspective to the entertainment industry.

Leonardo Ordóñez Díaz

2005-01-01

205

Oil and gas shows in mines of the Donbas  

Energy Technology Data Exchange (ETDEWEB)

Data on the emission of liquid hydrocarbons in mines of the Donbas are presented. Results of studying the composition of combustible gases inmines with the release of liquid hydrocarbons are analyzed. The effect of higher hydrocarbons on indications of the methane measurement equipment is examined. Recommendations to assure work safety in mines with emission of liquid hydrocarbons are given.

Kusygin, K.K.; Kedviga, S.N.; Kuz' min, D.V.; Petchenko, K.A.

1980-01-01

206

Improving co-located collaboration with show-through techniques  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Multi-user virtual reality systems enable natural interaction with shared virtual worlds. Users can talk to each other, gesture and point into the virtual scenery as if it were real. As in reality, referring to objects by pointing, results often in a situation whereon objects are occluded from the o...

Argelaguet Sanz, Fernando; Kunert, André; Kulik, Alexander; Froehlich, Bernd

207

Study shows significant emission reductions using E-95  

Energy Technology Data Exchange (ETDEWEB)

This article describes a study comparing the fuel efficiency, tailpipe emissions, fuel economy, horse power and drive ability of E-95 fuel (95% ethanol/5% unleaded gasoline) vs. premium unleaded gasoline in a 2.5 liter, 4 cyclinder General Motors engine. A table of tailpipe emissions results is given. Address for full report is given.

NONE

1995-12-31

208

Motion Generation for Glove Puppet Show with Procedural Animation  

Science.gov (United States)

Traditional Taiwanese glove puppet show is a unique form of performing art. In this work, we aim to use the aid of computer animation technologies to preserve this cultural heritage and create innovative ways of performance. By observing the demonstration of a puppet master, we analyze the characteristics of how a hand puppet is manipulated and design animation procedures mimicking the motion of a glove puppet. These procedures are implemented on a real-time animation platform for procedural animation. Through the system, we allow a user to perform glove puppet animation with high-level inputs. We hope that, with the help of this system, not only the art of manipulating a glove puppet can be systematically documented, but the entry barrier for learning it can also be greatly reduced.

Lin, Chih-Chung; Hou, Gee-Chin; Li, Tsai-Yen

209

Anger, Cognition, Ideology: What Crash Can Show Us About Emotion  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract (E): Sue J. Kim’s essay “Anger, Cognition, Ideology: What Crash Can Show Us About Emotion” argues for the relevance and importance of cognitive studies to ethnic and postcolonial literary studies, and vice versa. After surveying recent developments in the field of cognitive studies, the essay combines cultural and cognitive approaches in order to examine anger in and around the 2005 Paul Haggis film Crash.  Abstract (F): Dans cet article, l’auteur fait un plaidoyer pour l’application des études cognitives aux études ethniques et postcoloniales et inversement. L’essai présente d’abord un survol des récents développements dans le domaine des études cognitives, puis combine les approches culturelles et cognitives dans une lecture détaillée du thème de la colère dans le film Crash de Paul Haggis (2005). 

Sue J. Kim

2010-01-01

210

Low LET protons focused to submicrometer shows enhanced radiobiological effectiveness.  

UK PubMed Central (United Kingdom)

This study shows that enhanced radiobiological effectiveness (RBE) values can be generated focusing low linear energy transfer (LET) radiation and thus changing the microdose distribution. 20 MeV protons (LET = 2.65 keV µm(-1)) are focused to submicrometer diameter at the ion microprobe superconducting nanoprobe for applied nuclear (Kern) physics experiments of the Munich tandem accelerator. The RBE values, as determined by measuring micronuclei (RBE(MN) = 1.48 ± 0.07) and dicentrics (RBE(D) = 1.92 ± 0.15), in human-hamster hybrid (A(L)) cells are significantly higher when 117 protons were focused to a submicrometer irradiation field within a 5.4 × 5.4 µm(2) matrix compared to quasi homogeneous in a 1 × 1 µm(2) matrix applied protons (RBE(MN) = 1.28 ± 0.07; RBE(D) = 1.41 ± 0.14) at the same average dose of 1.7 Gy. The RBE values are normalized to standard 70 kV (dicentrics) or 200 kV (micronuclei) x-ray irradiation. The 117 protons applied per point deposit the same amount of energy like a (12)C ion with 55 MeV total energy (4.48 MeV u(-1)). The enhancements are about half of that obtained for (12)C ions (RBE(MN) = 2.20 ± 0.06 and RBE(D) = 3.21 ± 0.10) and they are attributed to intertrack interactions of the induced damages. The measured RBE values show differences from predictions of the local effect model (LEM III) that is used to calculate RBE values for irradiation plans to treat tumors with high LET particles.

Schmid TE; Greubel C; Hable V; Zlobinskaya O; Michalski D; Girst S; Siebenwirth C; Schmid E; Molls M; Multhoff G; Dollinger G

2012-10-01

211

A Paradox of Syntactic Priming: Why Response Tendencies Show Priming for Passives, and Response Latencies Show Priming for Actives  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Speakers tend to repeat syntactic structures across sentences, a phenomenon called syntactic priming. Although it has been suggested that repeating syntactic structures should result in speeded responses, previous research has focused on effects in response tendencies. We investigated syntactic prim...

Segaert, Katrien; Menenti, Laura; Weber, Kirsten; Hagoort, Peter

212

Glioma-associated endothelial cells show evidence of replicative senescence  

International Nuclear Information System (INIS)

The innately programmed process of replicative senescence has been studied extensively with respect to cancer, but primarily from the perspective of tumor cells overcoming this stringent innate barrier and acquiring the capacity for unlimited proliferation. In this study, we focus on the potential role of replicative senescence affecting the non-transformed endothelial cells of the blood vessels within the tumor microenvironment. Based on the well-documented aberrant structural and functional features of blood vessels within solid tumors, we hypothesized that tumor-derived factors may lead to premature replicative senescence in tumor-associated brain endothelial cells (TuBEC). We show here that glioma tissue, but not normal brain tissue, contains cells that express the signature of replicative senescence, senescence-associated ?-galactosidase (SA-?-gal), on CD31-positive endothelial cells. Primary cultures of human TuBEC stain for SA-?-gal and exhibit characteristics of replicative senescence, including increased levels of the cell cycle inhibitors p21 and p27, increased resistance to cytotoxic drugs, increased growth factor production, and inability to proliferate. These data provide the first demonstration that tumor-derived brain endothelial cells may have reached an end-stage of differentiation known as replicative senescence and underscore the need for anti-angiogenic therapies to target this unique tumor-associated endothelial cell population.

2007-04-01

213

Synthetic analogs of anoplin show improved antimicrobial activities.  

UK PubMed Central (United Kingdom)

We present the antimicrobial and hemolytic activities of the decapeptide anoplin and 19 analogs thereof tested against methicillin-resistant Staphylococcus aureus ATCC 33591 (MRSA), Escherichia coli (ATCC 25922), Pseudomonas aeruginosa (ATCC 27853), vancomycin-resistant Enterococcus faecium (ATCC 700221) (VRE), and Candida albicans (ATCC 200955). The anoplin analogs contain substitutions in amino acid positions 2, 3, 5, 6, 8, 9, and 10. We use these peptides to study the effect of altering the charge and hydrophobicity of anoplin on activity against red blood cells and microorganisms. We find that increasing the charge and/or hydrophobicity improves antimicrobial activity and increases hemolytic activity. For each strain tested, we identify at least six anoplin analogs with an improved therapeutic index compared with anoplin, the only exception being Enterococcus faecium, against which only few compounds are more specific than anoplin. Both 2Nal(6) and Cha(6) show improved therapeutic index against all strains tested. Copyright © 2013 European Peptide Society and John Wiley & Sons, Ltd.

Munk JK; Uggerhøj LE; Poulsen TJ; Frimodt-Møller N; Wimmer R; Nyberg NT; Hansen PR

2013-09-01

214

Enterococcus faecalis strains show culture heterogeneity in cell surface charge.  

Science.gov (United States)

Adhesion of micro-organisms to biotic and abiotic surfaces is an important virulence factor and involves different types of interactions. Enterococcus faecalis, a human commensal and an important opportunistic pathogen, has the ability to adhere to surfaces. Biliary stents frequently become clogged with bacterial biofilms, with E. faecalis as one of the predominant species. Six E. faecalis strains isolated from clogged biliary stents were investigated for the presence of specific biochemical factors involved in their adhesion: aggregation substances (Aggs) and the enterococcal surface protein (encoded by the esp gene). In addition, physico-chemical factors involved in adhesion (zeta potential and cell surface hydrophobicity) were determined, as well as the influence of ox bile on these properties. Two-thirds of the biliary stent isolates displayed culture heterogeneity in the pH dependence of their zeta potentials. Moreover, 24 out of 46 clinical isolates of E. faecalis, including 11 laboratory strains, also displayed such heterogeneity. The culture heterogeneity was demonstrated to be a stable trait, not caused by quorum sensing, not plasmid mediated, and independent of the presence of esp and Agg. Data presented show that culture heterogeneity in zeta potential enhances adhesion to an abiotic surface. A higher prevalence of culture heterogeneity in zeta potential in pathogenic as compared to non-pathogenic isolates could indicate that this phenomenon might play a role in virulence and putatively in pathogenesis. PMID:16514160

van Merode, Annet E J; van der Mei, Henny C; Busscher, Henk J; Waar, Karola; Krom, Bastiaan P

2006-03-01

215

Show: Dr. H, the life and death of pancakes  

CERN Document Server

Dr. H, the life and death of pancakes, a comic theatrical creation, written and performed by Heiko Buchholz.   Monday 2 April 2012 in German Tuesday 3 April 2012 in English Wednesday 4 April 2012 in French 8:30 p.m. at the Globe of Science and Innovation. This production takes a comic look at scientific methods, as applied to a common object: the pancake. More specifically, Dr H. regales his audience with statistics, experiments and scientific data surrounding this egg-and-milk-based culinary delight. And although these zany sketches are nothing short of absurd, the audience is drawn in more often than you might expect… and taken on quite an unexpected journey into the behavioural disorders, personality quirks and psychoanalysis of the base pancake. This show playfully mocks scientific logic and discourse, forcing the audience to reflect on their gullibility in the face of science and its impenetrable jargon. It purports to be neither explanation nor illustration of scientific fact,...

2012-01-01

216

Motherless rats show deficits in maternal behavior towards fostered pups.  

UK PubMed Central (United Kingdom)

Complete maternal deprivation in rats, through artificial rearing (AR), produces deficits in subsequent maternal behavior of the offspring. These deficits are partially reversed when isolated pups are provided with additional tactile stimulation designed to simulate maternal licking (e.g., Gonzalez et al. [2001] Developmental Psychobiology, 38, 11-32). These findings highlight the importance of the early maternal environment in subsequent development. However, given the possibility that prenatal environments may differ between AR and maternally reared (MR) offspring, the deficits in the behavior of AR mothers may be driven by the characteristics of their pups derived from the effects of an altered prenatal environment. Hence differences in the neonatal pups of AR mothers may produce the alterations in the AR maternal behavior. To rule out this possibility, we employed a fostering paradigm where AR and MR mothers received cross-fostered mother-reared pups. AR mothers showed the same level of deficits in maternal behavior towards MR foster pups as they do with their own pups and these deficits were partially reversed with additional tactile stimulation. Hence, maternal behavior deficits reported in mothers who had been reared in isolation are due primarily to the direct effects of the earlier experience on mechanisms regulating their maternal behavior and not to the effects on their offspring.

Palombo DJ; Nowoslawski M; Fleming AS

2010-03-01

217

Aggressive management of tibial osteomyelitis shows good functional outcomes.  

UK PubMed Central (United Kingdom)

Background: Severe open tibial fractures can be successfully treated acutely with a combined orthopedic and plastic surgery approach, but a proportion will go on to develop chronic osteomyelitis. For the past 6 years, an aggressive approach of bone and soft tissue debridement followed by skeletal reconstruction and vascularized tissue transfer has been pursued by the orthopedic and plastic surgery teams at Liverpool Hospital. We present the results of our patient series. Methods: All patients treated for chronic osteomyelitis by combined skeletal stabilization, debridement, and flap coverage between January 2000 and July 2006 were included. Clinical record review was combined with patient interviews and questionnaires. Outcome measures included fracture union, stable soft tissue coverage, freedom from infection, mobility, return to work/sport, and pain. Results: Twelve patients were followed up after a mean of 4.2 years. Patients had undergone a mean of 8.4 procedures prior to treatment, and a mean of 2.5 procedures as part of their treatment. We achieved fracture union, stable soft tissue coverage, and eradicated infection in all patients. All patients were walking, 10 unaided, and 80% had returned to work. All but one patient involved in sport at the time of injury had returned to sport. Two patients had mild pain when walking long distances only. Conclusion: Skeletal stabilization, debridement, and flap coverage is costly and complex surgery. However, in our series, these interventions resulted in eradication of infection and good clinical outcomes in most cases, providing an alternative to both amputation and long-term antibiotic therapy.

Campbell R; Berry MG; Deva A; Harris IA

2011-01-01

218

New Systems Showing the Light-Time Effect  

CERN Multimedia

Two Algol-type eclipsing binary systems (EW Lyr and IV Cas) have been investigated for period changes. Our study was primarily focused on the light-time effect with an alternative explanation by magnetic activity cycles. In the case of EW Lyr we have found a third body in the orbit with a period of about 78 years, an amplitude A=0.052 days and orbital eccentricity e=0.57. For IV Cas the long period is 58 years, amplitude A=0.034 days and zero eccentricity. With these results we are also able to calculate mass functions and minimal masses of these components.

Zasche, P

2006-01-01

219

Surface-Supported Hydrocarbon ? Radicals Show Kondo Behavior.  

UK PubMed Central (United Kingdom)

Stable hydrocarbon radicals are utilized as spin standards and prototype metal-free molecular magnets able to withstand ambient conditions. Our study presents experimental results obtained with submolecular resolution by scanning tunneling microscopy and spectroscopy from monomers and dimers of stable hydrocarbon ? radicals adsorbed on the Au(111) surface at 7-50 K. We provide conclusive evidence of the preservation of the radical spin-1/2 state, aiming to establish ?,?-bisdiphenylene-?-phenylallyl (BDPA) on Au(111) as a novel Kondo system, where the impurity spin is localized in a metal-free ? molecular orbital of a neutral radical state in gas phase preserved on a metal support.

Müllegger S; Rashidi M; Fattinger M; Koch R

2013-03-01

220

Inflammatory breast cancers in Tunisia and France show similar immunophenotypes.  

UK PubMed Central (United Kingdom)

PURPOSE: Inflammatory breast cancers (IBC) have specific immunophenotypic profiles as compared to non-inflammatory (non-IBC): combined differential expression of estrogen receptor, Ki67, E-cadherin, MUC1, and ERBB2 can be used as an IBC signature. It is thought that IBC occurs with a high frequency in Tunisia. The aim of this study is to evaluate this signature on a Tunisian series. METHODS: The expression of five proteins (E-cadherin, ERBB2, estrogen receptor, Ki67, MUC1) was studied by immunohistochemistry on a consecutive series of 91 cases of IBC (T4D) treated at Tunisian Salah Azaiz Institute (ISA) and deposited in a tissue microarray (TMA). Results were compared to the same study on a series of 85 cases treated in France. RESULTS: The ISA cases were characterized by a significantly younger age of patients (median: 42 years old in ISA for 53.5 in IPC, p=0.00042) and a higher frequency of invasive micropapillary pattern. None of the five parameters was expressed differentially in the two series. In non-metastatic patients, high level of proliferation (Ki67) and overexpression of ERBB2 were associated with poor outcome. CONCLUSION: The IBC from Tunisia were not different from those observed in France on the basis of IHC profiles. However, the younger age of the patients suggest a specific epidemiological context that should be investigated.

Charafe-Jauffret E; Mrad K; Intidhar Labidi S; Ben Hamida A; Ben Romdhane K; Ben Abdallah M; Ginestier C; Esterni B; Birnbaum D; Ben Ayed F; Xerri L; Viens P; Mezlini A; Jacquemier J

2007-08-01

 
 
 
 
221

Birds introduced in new areas show rest disorders.  

Science.gov (United States)

All colonizing individuals have to settle in a novel, conspecific-free environment. The introduction process should be poorly compatible with a good rest. We compared the resting behaviour of radio-tagged house sparrows (Passer domesticus) experimentally translocated into new, conspecific-free areas (introduced individuals, n = 10), with that of translocated sparrows that settled in naturally established populations (controls, n = 5). Resting habits of introduced sparrows markedly differed from those of control birds: they did not vocalize before going to roost, they changed their roosting habitat and they roosted 24 ± 7 min later and departed 13 ± 4 min earlier from the roost, resulting in a 5% rest debt. Because colonizing a new environment is expected to require heightened cognitive and physical activities, which in turn are constrained by the quality and duration of rest, we hypothesize that rest disorders and resulting cognitive impairments of newly released individuals could functionally contribute to the low post-release survival observed in (re)introduction attempts. PMID:23904567

Henry, Pierre-Yves; Salgado, Catalina Landeta; Muñoz, Fanny Paucar; Wikelski, Martin C

2013-07-31

222

Birds introduced in new areas show rest disorders.  

UK PubMed Central (United Kingdom)

All colonizing individuals have to settle in a novel, conspecific-free environment. The introduction process should be poorly compatible with a good rest. We compared the resting behaviour of radio-tagged house sparrows (Passer domesticus) experimentally translocated into new, conspecific-free areas (introduced individuals, n = 10), with that of translocated sparrows that settled in naturally established populations (controls, n = 5). Resting habits of introduced sparrows markedly differed from those of control birds: they did not vocalize before going to roost, they changed their roosting habitat and they roosted 24 ± 7 min later and departed 13 ± 4 min earlier from the roost, resulting in a 5% rest debt. Because colonizing a new environment is expected to require heightened cognitive and physical activities, which in turn are constrained by the quality and duration of rest, we hypothesize that rest disorders and resulting cognitive impairments of newly released individuals could functionally contribute to the low post-release survival observed in (re)introduction attempts.

Henry PY; Salgado CL; Muñoz FP; Wikelski MC

2013-01-01

223

Neutrino Radiation Showing a Christodoulou Memory Effect in General Relativity  

CERN Document Server

We describe neutrino radiation in general relativity by introducing the energy-momentum tensor of a null fluid into the Einstein equations. Investigating the geometry and analysis at null infinity, we prove that a component of the null fluid enlarges the Christodoulou memory effect of gravitational waves. The description of neutrinos in general relativity as a null fluid can be regarded as a limiting case of a more general description using the massless limit of the Einstein-Vlasov system. The present authors with co-authors have work in progress to generalize the results of this paper using this more general description. Gigantic neutrino bursts occur in our universe in core-collapse supernovae and in the mergers of neutron star binaries.

Bieri, Lydia

2013-01-01

224

Australian plants show anthelmintic activity toward equine cyathostomins in vitro.  

Science.gov (United States)

Anthelmintic resistance in gastrointestinal parasites of horses is an increasing problem, particularly in cyathostomins, and there is a need to find alternative means for the control of these parasites. We screened crude extracts from 37 species of Australian native plants for their anthelmintic activity in vitro against cyathostomin larvae (development from egg to third larval stage), with the aim of identifying those species that may be suitable for incorporation into sustainable parasite management programs. Water extracts from seven species, namely Acacia baileyana, Acacia melanoxylon, Acacia podalyriifolia, Alectryon oleifolius, Duboisia hopwoodii, Eucalyptus gomphocephala and Santalum spicatum completely inhibited larval development (100% inhibition compared to the control), while another 10 species caused 90% inhibition at the initial screening concentration of 1400?g of extractable solids/mL. The seven most potent extracts produced IC50 values (concentration of extract which resulted in a 50% inhibition of development) in the range 30.9-196?g/mL. Fourteen extracts were incubated with polyvinylpolypyrrolidone (PVPP) before the assays, which removed the anthelmintic activity from 12 of these extracts, indicating that tannins were likely to be the bioactive compound responsible for the effect, while in two species, i.e. A. melanoxylon and D. hopwoodii, compounds other than tannins were likely to be responsible for their anthelmintic action. Our results suggest that a number of Australian native plants have significant anthelmintic activity against cyathostomin larval development in vitro. There is potential for these plants to be used as part of sustainable parasite control programs in horses, although more research is needed to identify the compounds responsible for the anthelmintic effects and confirm their activity in vivo. PMID:23394801

Payne, S E; Kotze, A C; Durmic, Z; Vercoe, P E

2013-01-23

225

Periostin shows increased evolutionary plasticity in its alternatively spliced region  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract Background Periostin (POSTN) is a secreted extracellular matrix protein of poorly defined function that has been related to bone and heart development as well as to cancer. In human and mouse, it is known to undergo alternative splicing in its C-terminal region, which is devoid of known protein domains. Differential expression of periostin, sometimes of specific splicing isoforms, is observed in a broad range of human cancers, including breast, pancreatic, and colon cancer. Here, we combine genomic and transcriptomic sequence data from vertebrate organisms to study the evolution of periostin and particularly of its C-terminal region. Results We found that the C-terminal part of periostin is markedly more variable among vertebrates than the rest of periostin in terms of exon count, length, and splicing pattern, which we interpret as a consequence of neofunctionalization after the split between periostin and its paralog transforming growth factor, beta-induced (TGFBI). We also defined periostin's sequential 13-amino acid repeat units - well conserved in teleost fish, but more obscure in higher vertebrates - whose secondary structure is predicted to be consecutive beta strands. We suggest that these beta strands may mediate binding interactions with other proteins through an extended beta-zipper in a manner similar to the way repeat units in bacterial cell wall proteins have been reported to bind human fibronectin. Conclusions Our results, obtained with the help of the increasingly large collection of complete vertebrate genomes, document the evolutionary plasticity of periostin's C-terminal region, and for the first time suggest a basis for its functional role.

Hoersch Sebastian; Andrade-Navarro Miguel A

2010-01-01

226

Contaminants in tracked seabirds showing regional patterns of marine pollution.  

UK PubMed Central (United Kingdom)

Ocean-scale monitoring of pollution is challenging. Seabirds are useful indicators because they travel over a broad foraging range. Nevertheless, this coarse spatial resolution is not fine enough to discriminate pollution in a finer scale. Previous studies have demonstrated that pollution levels are higher in the Sea of Japan and South and East China Seas than the Northen Pacific Ocean. To test these findings in a wide-ranging animal, we tracked streaked shearwaters (Calonectris leucomelas) from four islands in Japan using global positioning system (GPS) and measured persistent organic pollutants (POPs) in the oil of their preen glands. The POPs did not change during 6 to 21 days when birds from Awashima were foraging only in the Sea of Japan, while it increased when they crossed to the Pacific through the Tsugaru Strait and foraged along the eastern coast of Hokkaido where industrial cities occur. These results indicate that POPs in the oil reflect relatively short-term exposure. Concentrations of POPs displayed greater variation among regions. Total polychlorinated biphenyls were highest in birds foraging in a small area of the semiclosed Seto Inland Sea surrounded by urbanized coast, p,p'-dichlorodiphenyltrichloroethane (DDT) was highest in birds foraging in the East China Sea, and total hexachlorocyclohexanes were highest in birds foraging in the Sea of Japan. All were lowest in birds foraging in the Pacific. This distribution of POPs concentration partly agrees with previous findings based on mussels, fish, and seawater and possibly reflects the mobility and emission sources of each type of POP. These results highlight the importance of information on the foraging area of highly mobile top predators to make them more effective monitors of regional marine pollution.

Ito A; Yamashita R; Takada H; Yamamoto T; Shiomi K; Zavalaga C; Abe T; Watanabe S; Yamamoto M; Sato K; Kohno H; Yoda K; Iida T; Watanuki Y

2013-07-01

227

Students entering internship show readiness in the nutrition care process.  

UK PubMed Central (United Kingdom)

BACKGROUND: The British Dietetic Association and the International Confederation of Dietetic Associations are developing an international model for dietetics practice as an aid in providing evidence-based practice. In the USA, undergraduate programmes are mandated by the Academy of Nutrition and Dietetics (formerly the American Dietetic Association) to incorporate the nutrition care process (NCP) into the curriculum so that students can use the process during their dietetic internship and later practice. The present study aimed to assess interns' readiness in the NCP prior to beginning a dietetic internship. METHODS: Before starting the internship, the 40 interns in the 2009-2010 class of a university-based internship were sent an e-mail requesting they complete an online survey. Questions inquired about their NCP background with respect to: academic preparation, work or volunteer experiences, knowledge and confidence in ability to apply the NCP. Survey results were analysed with SPSS statistical software (SPSS Inc., Chicago, IL, USA). RESULTS: The 39 interns completing the survey indicated they had prior exposure to the NCP. All but one reported that their academic coursework covered the NCP. Approximately half of the interns worked or volunteered in settings that used the NCP. Overall, students correctly answered most of the questions assessing their basic knowledge in the NCP. Thirty-seven of the 39 interns had some confidence or felt confident in their ability to apply the NCP during internship rotations. CONCLUSIONS: This distance internship attracts students from all over the USA, and so the findings of the present study shed light on current undergraduate preparation in the NCP.

Baker SD; Cotugna N

2013-10-01

228

"The show must go on!" Beserings van dramastudente tydens opleiding  

Directory of Open Access Journals (Sweden)

Full Text Available "THE SHOW MUST GO ON!" LIABILITY WHEN IT COMES TO DRAMA STUDENTS WHEN INJURED WHILE IN TRAININGThis article emphasises the uncertainty in the relationship between a student undergoing practical training and his/her lecturer or university, if the student should be injured and wants to claim compensation. One must first establish whether the student can be described as an employee of the lecturer or university, or as a vocational worker or independent contractor. Once the status of the student has been established, the relevant legislation can be determined, whether it is the Labour Relations Act or the Basic Conditions of Employment. It is, however, not that simple and a person in the capacity of a student does not accord with the definition of an employee or an independent contractor or a vocational worker. One will have to rely on the assumption in section 83A in the Basic Conditions of Employment that a student is an employee when he does practical training for the benefit of the university. The Occupational Health and Safety Act requires employers to assure that the workplace is a safe environment for employees, with the minimum risks involved. The Compensation for Occupational Injuries and Diseases Act makes it possible for an employee to claim compensation when such a risk becomes a reality.This article also tries to compare the situation of a student sports person injured while participating in university sports, and a drama student injured during a performance or rehearsal of a play. It is stated that the relationship between the drama student and lecturer is similar to the relationship between a sports person and his/her coach, but the relationship differs in that a sports person’s risk of getting hurt is much greater than that of a drama student, The contracts between sports players and their authorities are also stipulated in much more detail than the contracts (if any) between the drama students and the university. It is concluded that the legislation is not clear on the specific matters where a student undergoes practical training while they are still studying. The suggestion is that a sectoral determination must be put in place to regulate the relationship, the remuneration, the working hours and the working conditions and risks involved.The article is in Afrikaans.

R Snyman; J Deacon

2009-01-01

229

Dizer-mostrar o estranho/ Saying-showing strangeness  

Scientific Electronic Library Online (English)

Full Text Available Abstract in portuguese Este trabalho explora a vitalidade contemporânea de duas enfáticas vozes do século XX: Ludwig Wittgenstein e Samuel Beckett. Consideram-se em especial as seguintes divisas: de Wittgenstein, nada está oculto (Investigações, § 435); de Beckett, nada a expressar (Três diálogos com George Duthuit, I). O dito de Wittgenstein é muitas vezes tomado como marca de renúncia à distinção, por ele antes sustentada, entre aquilo que se pode dizer e aquilo que apenas se mo (more) stra (Tractatus, Prefácio, 6.522). O dito de Beckett é, por sua vez, frequentemente visto como indício de uma visão cética da linguagem, que a condena a uma espécie de maldição da autorreferência. Tais formas de ler tendem a se ligar às percepções, bastante disseminadas, de que Wittgenstein escreve o comum (o "ordinário"); e Beckett, o absurdo. Questiono aspectos dessas duas produtivas leituras, sustentando que, de forma a meu ver um pouco debilitante, elas tendem a ignorar, ou talvez a apaziguar, um estranho que insiste em se dizer-mostrar na prosa poética dos dois autores. Abstract in english This paper explores the contemporary strength of two of last century's most emphatic voices: Ludwig Wittgenstein and Samuel Beckett. The following mottos are brought together with special attention: nothing is hidden, by Wittgenstein (Philosophical Investigations, §435); and nothing to express, by Beckett (Three dialogues with Georges Duthuit, I). Wittgenstein's saying is frequently taken as indication that he renounces his earlier distinction between what can be said an (more) d what can only be shown (Tractatus, Preface, 6.522). Beckett's saying is, in turn, often seen as evidence of a skeptical take on language, whereas it is, so to speak, doomed to self-reference. These interpretations tend to be linked to the widespread perceptions that Wittgenstein writes the ordinary, whereas Beckett writes the absurd. I question some aspects of these two productive readings, arguing that, in a somewhat debilitating manner, they tend to ignore, or perhaps pacify, a strangeness that insists in saying-showing itself in the poetic prose of both authors.

Martins, Helena

2012-06-01

230

Unexpected show up of incomplete fusion at low projectile energies  

International Nuclear Information System (INIS)

[en] In this paper, some of the important findings of recent measurements performed to study incomplete fusion at low bombarding energies (i.e., E(lab) ? 4-7 MeV/nucleon) in 12C,16O+169Tm systems are briefly summarized. The spin-distributions of xn, pxn, ?xn/2?xn channels have been measured to probe entirely different ?-emission patterns (and feeding intensity profiles) during the de-excitation of complete and incomplete fusion objects. Incomplete fusion strength function has been deduced (from the analysis of experimental excitation functions in context of equilibrated compound nucleus decay) to achieve information of onset and strength of incomplete fusion in terms of various entrance channel parameters. Presence of incomplete fusion at slightly above barrier energies has been confirmed by the measurement of linear momentum distribution of heavy recoils. Present results conclusively demonstrate, the existence of incomplete fusion at low bombarding energies, its strong dependence on entrance channel parameters, and the possibility to populate high spin states. (authors)

2011-01-01

231

Cubic Metallic Phase of Aluminum Hydride Showing Improved Hydrogen Desorption  

Science.gov (United States)

AlH3 is of great interest for hydrogen storage applications, with a particularly attractive feature being its large hydrogen capacity of 10 wt.%. Here we report the results of our density functional theory study of the dehydrogenation properties in a cubic phase of AlH3. The metallic nature of the electronic structure entails a more favorable hydrogen removal energy which is lowered by 75% compared to the insulating hexagonal phase. This remarkable reduction in the Al--H bond strength might bear important consequences for feasible applications of AlH3 as an on-board hydrogen storage material for mobile applications. Suggestions are made how the cubic phase could be prepared and stabilized at ambient pressure by off-board quenching. See also: R. H. Scheicher, D. Y. Kim, S. Lebègue, B. Arnaud, M.Alouani, and R. Ahuja, Appl. Phys. Lett. 92, 201903 (2008) and D. Y. Kim, R. H. Scheicher, and R. Ahuja, Phys. Rev. B 78, 100102(R) (2008).

Scheicher, Ralph H.; Kim, Duck Young; Ahuja, Rajeev

2009-03-01

232

Unexpected show up of incomplete fusion at low projectile energies  

Directory of Open Access Journals (Sweden)

Full Text Available In this paper, some of the important ?ndings of recent measurements performed to study incomplete fusion at low bombarding energies (i.e., Elab ? 4-7 MeV/nucleon) in 12C, 16O+169Tm systems are brie?y summarized. The spin-distributions of xn, pxn, ?xn/2?xn- channels have been measured to probe entirely different ?-emission patterns (and feeding intensity pro?les) during the de-excitation of complete and incomplete fusion objects. Incomplete fusion strength function has been deduced (from the analysis of experimental excitation functions in context of equilibrated compound nucleus decay) to achieve information of onset and strength of incomplete fusion in terms of various entrance channel parameters. Presence of incomplete fusion at slightly above barrier energies has been con?rmed by the measurement of linear momentum distribution of heavy recoils. Present results conclusively demonstrate, the existence of incomplete fusion at low bombarding energies, its strong dependence on entrance channel parameters, and the possibility to populate high spin states.

Singh Pushpendra P.; Yadav Abhishek; Sharma Vijay R.; Singh D.P.; Gupta Unnati; Sharma Manoj K.; Kumar R.; Golda K.S.; Singh R.P.; Muralithar S.; Singh B.P.; Bhowmik R.K.; Prasad R.

2011-01-01

233

Elderly hypertensives show decreased cognitive performance compared with elderly normotensives.  

UK PubMed Central (United Kingdom)

BACKGROUND: Essential hypertension has been associated with decreased cognitive performance; however, the literature is conflicting. OBJECTIVE: This study aims at comparing cognitive performance between elderly normotensives ("N"; n = 17; age 68 ± 1; blood pressure = 133 ± 3/74 ±2 mmHg) and hypertensives ("H"; n = 28; age 69 ± 1, blood pressure = 148 ± 4/80 ± 1mmHg) with at least 5 years of education. METHODS: The comprehensive neuropsychological assessment was comprised of the Cambridge Cognition-Revised (CAMCOG-R), the Trail Making Test A and B (TMT A and B) and the Rey Auditory Verbal Learning Test (RAVLT). RESULTS: Elderly hypertensives presented lower CAMCOG-R global scores (N = 87.6 ± 1.8; H = 78.6 ± 1.4; p = 0.002). The hypertensive's performance was slower in the TMT A and B (TMT A: N = 39 ± 3s; H = 57 ± 3s; p = 0.001; TMT B: N = 93 ± 7s; H = 124 ± 7s; p = 0.006), which was also reflected in smaller percentiles achieved by hypertensives in these tests. Hypertensive subjects exhibited a significantly lower RAVLT summation score (N = 51.8 ± 1.7; H = 40.7 ± 1.5; p < 0.0001). Even when adjusted for age, sex, education and depression symptoms, hypertension was an independent predictor of cognitive performance as measured by CAMCOG-R global score, TMT A and RAVLT summation score. CONCLUSION: Cognitive performance is lower in elderly hypertensives as compared with elderly normotensives.

Matoso JM; Santos WB; Moreira Ide F; Lourenço RA; Correia ML

2013-05-01

234

Cluster headache shows no association with rapid eye movement sleep.  

UK PubMed Central (United Kingdom)

BACKGROUND: The connection of cluster headache (CH) attacks with rapid eye movement (REM) sleep has been suggested by various studies, while other authors challenge this assumption. We performed serial polysomnography to determine the association of nocturnal CH attacks and sleep. METHODS: Five patients diagnosed with CH (two with the episodic and three with the chronic subtype) were included and studied over four consecutive nights to evaluate connections between attacks onset and sleep stage. RESULTS: Twenty typical CH attacks were reported. Thirteen of these attacks arose from sleep. Seven attacks were reported after waking in the morning or shortly before going to sleep. The beginnings of sleep-related attacks were distributed arbitrarily between different non-REM sleep stages. No association of CH attacks with REM or sleep disordered breathing was observed. Increased heart rate temporally associated with transition from one sleep state to another was observed before patients awoke with headache. Total sleep time, total wake time, arousal index and distribution of non-REM sleep stages were different between chronic and episodic CH. CONCLUSION: CH attacks are not associated with REM sleep. Brain regions involved in sleep stage transition might be involved in pathophysiology of CH. Differences in sleep characteristics between subgroups might indicate adaptation processes or underlying pathophysiology.

Zaremba S; Holle D; Wessendorf TE; Diener HC; Katsarava Z; Obermann M

2012-03-01

235

[Interferon alpha antibodies show no cross reactions with typical autoantibodies  

UK PubMed Central (United Kingdom)

Patients treated with natural human interferon alpha develop anti-interferon antibodies (IFN-AB) only in very rare cases. By contrast, patients with autoimmune disorders are able to generate high-titered IFN-AB against endogenous interferon alpha. One explanation for the development of auto-IFN-AB could be cross-reactivity with typical autoimmune antigens. We investigated the cross-reactivity of 3 high-titered IgG IFN-AB of female autoimmune patients (aged 32, 36, 74 years; two severe cases of SLE, one case of autoimmune thyroiditis) as well as 25 low-titered natural IgM IFN-AB of healthy blood donors (aged 19-48 years). Typical autoimmune antigens including dsDNA, ENA, as well as natural interferon beta and recombinant interferon gamma are not able to inhibit binding of IFN-AB to interferon alpha in an ELISA test system. Preincubation of sera containing either dsDNA antibodies (dsDNA-AB) (24 patients), thyroid peroxidase (TPO-AB) (9 patients) or thyroglobulin (TG-AB) (12 patients) with interferon alpha resulted in no change in the respective autoantibody titer. These data suggest that there is no cross-reactivity between IFN-alpha-AB and dsDNA-AB, TPO-AB or TG-AB. Thus, an explanation for the occurrence of IFN-AB in autoimmune disorders cannot be found in a cross-reaction between interferon alpha with typical autoimmune antigens.

Görg S; Klouche M; Wilhelm D; Kirchner H

1993-04-01

236

OGJ group earnings show big gain for 1993  

International Nuclear Information System (INIS)

Earnings for Oil and Gas Journal's group of 22 large US oil companies advanced sharply last year, increasing 70.9% from 1992. Group profits totaled $16.1 billion, with the gain stemming largely from lack of one time charges that depressed earnings in 1992. Adoption of new accounting rules associated with future postretirement costs caused the 1992 charges. US exploration and production earnings were mixed, tied in part to oil and gas production volumes. Higher gas prices and production helped boost earnings for a number of companies. But the earnings improvement from gas was offset by reduced oil production and prices. Results from non-U.S. E and P also were mixed. Average worldwide crude oil export prices were down from year earlier levels. However, for some companies this was offset by higher production levels and lower exploration costs. Earnings from refining and marketing were improved from 1992 levels, particularly for non-US operations. Lower feedstock costs, especially in the fourth quarter, helped boost earnings in this sector. Refining earnings gains also flowed from lower costs due to restructuring and an accompanying improvement in operating efficiency. The paper discusses world trends, operations and prices, US exploration and production, non-US E and P, US and non-US refining and marketing, petrochemicals, and the forecast for future demand

237

OGJ group earnings show big gain for 1993  

Energy Technology Data Exchange (ETDEWEB)

Earnings for Oil and Gas Journal's group of 22 large US oil companies advanced sharply last year, increasing 70.9% from 1992. Group profits totaled $16.1 billion, with the gain stemming largely from lack of one time charges that depressed earnings in 1992. Adoption of new accounting rules associated with future postretirement costs caused the 1992 charges. US exploration and production earnings were mixed, tied in part to oil and gas production volumes. Higher gas prices and production helped boost earnings for a number of companies. But the earnings improvement from gas was offset by reduced oil production and prices. Results from non-U.S. E and P also were mixed. Average worldwide crude oil export prices were down from year earlier levels. However, for some companies this was offset by higher production levels and lower exploration costs. Earnings from refining and marketing were improved from 1992 levels, particularly for non-US operations. Lower feedstock costs, especially in the fourth quarter, helped boost earnings in this sector. Refining earnings gains also flowed from lower costs due to restructuring and an accompanying improvement in operating efficiency. The paper discusses world trends, operations and prices, US exploration and production, non-US E and P, US and non-US refining and marketing, petrochemicals, and the forecast for future demand.

Beck, R.J.; Sanders, V.

1994-04-04

238

[Differential diagnostics of stomach contents showing blue discoloration].  

Science.gov (United States)

A 42-year-old man evidently had died from an intoxication. On the basis of the findings at scene it was primarily assumed that the man had ingested a larger quantity of an ethylene glycol-containing antifreeze for suicidal purposes. The man was said to have had an alcohol problem and did not only consume drinking alcohol, but also other alcoholic liquids. At autopsy, a bluish liquid with an aromatic smell was found in the oesophagus and stomach. However, toxicological analyses did not furnish evidence of ethylene glycol--as expected--but a potentially fatal concentration of ethanol (blood alcohol concentration 4.01 per mille). The blue colour (patent blue C.I.42051) came from a liquid used in the wind-screen washer system in winter, which now contains ethanol (denatured with 2-butanone) instead of ethylene glycol. The results of the toxicological findings including the analysis of congener alcohols and the differential diagnostics of blue-coloured stomach contents are discussed. PMID:21404548

Nadjem, Hadi; Perdekamp, Markus Grosse; Auwärter, Volker; Stefan, Pollak; Thierauf, Annette

239

[Differential diagnostics of stomach contents showing blue discoloration].  

UK PubMed Central (United Kingdom)

A 42-year-old man evidently had died from an intoxication. On the basis of the findings at scene it was primarily assumed that the man had ingested a larger quantity of an ethylene glycol-containing antifreeze for suicidal purposes. The man was said to have had an alcohol problem and did not only consume drinking alcohol, but also other alcoholic liquids. At autopsy, a bluish liquid with an aromatic smell was found in the oesophagus and stomach. However, toxicological analyses did not furnish evidence of ethylene glycol--as expected--but a potentially fatal concentration of ethanol (blood alcohol concentration 4.01 per mille). The blue colour (patent blue C.I.42051) came from a liquid used in the wind-screen washer system in winter, which now contains ethanol (denatured with 2-butanone) instead of ethylene glycol. The results of the toxicological findings including the analysis of congener alcohols and the differential diagnostics of blue-coloured stomach contents are discussed.

Nadjem H; Perdekamp MG; Auwärter V; Stefan P; Thierauf A

2011-01-01

240

Oklahoma Cherokee formation study shows benefits of gas tax credits  

Energy Technology Data Exchange (ETDEWEB)

To no one's surprise, the administration's recently released energy initiative package does not advocate the use of tax incentives such as the Internal Revenue Code Sec. 29 (tight sand gas) credit that expired Dec. 31, 1992. This is unfortunate since tax credits do stimulate drilling, as the authors' recent study of Oklahoma's Pennsylvanian age Cherokee formation demonstrates. Within this 783,000 acre study area, more than 130 additional wells were drilled between 1991--92 because of tax credit incentives. And such tax credits also increase total federal tax revenues by causing wells to be drilled that would not have been drilled or accelerating the drilling of wells, thereby increasing taxable revenue. In short, tax credits create a win-win situation: they stimulate commerce, increase tax revenues, reduce the outflow of capital to foreign petroleum projects, and add to the nation's natural gas reserve, which is beneficial for national security, balance of payments, the environment, and gas market development. The paper discusses the study assumptions, study results, and the tax credit policy.

Stanley, B.J.; Cline, S.B. (Hefner Corp., Oklahoma City, OK (United States))

1994-01-10

 
 
 
 
241

Global Uranium Supply Ensured for Long Term, New Report Shows  

International Nuclear Information System (INIS)

Full text: Uranium resources and production are on the rise with the security of uranium supply ensured for the long term, according to a new report by the OECD Nuclear Energy Agency (NEA) and the International Atomic Energy Agency (IAEA). Uranium 2011: Resources, Production and Demand, commonly referred to as the ''Red Book'', shows that total identified uranium resources have grown 12.5% since 2008. However, the costs of production have also increased, leading to reductions in lower cost category resources. These figures, which reflect the situation as of 1 January 2011, mean that total identified resources are sufficient for over 100 years of supply based on current requirements. Global uranium mine production increased by over 25% between 2008 and 2010 because of significantly increased production in Kazakhstan, currently the world's leading producer. The increased resource base has been achieved thanks to a 22% increase in uranium exploration and mine development expenditures between 2008 and 2010, which in 2010 totalled over $2 billion. Demand for uranium is expected to continue to rise for the foreseeable future. Although the Fukushima Daiichi nuclear accident has affected nuclear power projects and policies in some countries, nuclear power remains a key part of the global energy mix. Several governments have plans for new nuclear power plant construction, with the strongest expansion expected in China, India, the Republic of Korea and the Russian Federation. The speed and magnitude of growth in generating capacity elsewhere is still to be determined. By the year 2035, according to the joint NEA-IAEA Secretariat, world nuclear electricity generating capacity is projected to grow from 375 GWe net (at the end of 2010) to between 540 GWe net in the low demand case and 746 GWe net in the high demand case, increases of 44% and 99% respectively. Accordingly, world annual reactor-related uranium requirements are projected to rise from 63 875 tonnes of uranium metal (tU) at the end of 2010 to between 98 000 tU and 136 000 tU by 2035. The currently defined uranium resource base is more than adequate to meet high-case requirements through 2035 and well into the foreseeable future. Although ample resources are available, meeting projected demand will require timely investments in uranium production facilities. This is because of the long lead times (typically in the order of ten years or more in most producing countries) required to develop production facilities that can turn resources into refined uranium ready for nuclear fuel production. With uranium production ready to expand to new countries, efforts are being made to develop transparent and well-regulated operations similar to those used elsewhere to minimise potential environmental and local health impacts. Although not the primary focus of the Red Book, activity updates on the environmental aspects of the uranium production cycle are included in the national reports in this edition. While the status of supply and demand is considered from the perspective of technologies in use today, the deployment of advanced reactors and fuel cycle technologies can also positively affect the long-term availability of uranium, conceivably extending the time horizon of the currently defined resource base to thousands of years. These are some of the findings in the just-published Uranium 2011: Resources, Production and Demand, a joint study by the OECD/NEA and the IAEA, carried out in co-operation with their member countries. This is the 24th edition of this periodic assessment (currently every two years) which has been published since the mid-1960s. (IAEA)

2011-01-01

242

Intracortical Bone Remodeling Variation Shows Strong Genetic Effects.  

UK PubMed Central (United Kingdom)

Intracortical microstructure influences crack propagation and arrest within bone cortex. Genetic variation in intracortical remodeling may contribute to mechanical integrity and, therefore, fracture risk. Our aim was to determine the degree to which normal population-level variation in intracortical microstructure is due to genetic variation. We examined right femurs from 101 baboons (74 females, 27 males; aged 7-33 years) from a single, extended pedigree to determine osteon number, osteon area (On.Ar), haversian canal area, osteon population density, percent osteonal bone (%On.B), wall thickness (W.Th), and cortical porosity (Ct.Po). Through evaluation of the covariance in intracortical properties between pairs of relatives, we quantified the contribution of additive genetic effects (heritability [h (2)]) to variation in these traits using a variance decomposition approach. Significant age and sex effects account for 9 % (Ct.Po) to 21 % (W.Th) of intracortical microstructural variation. After accounting for age and sex, significant genetic effects are evident for On.Ar (h (2) = 0.79, p = 0.002), %On.B (h (2) = 0.82, p = 0.003), and W.Th (h (2) = 0.61, p = 0.013), indicating that 61-82 % of the residual variation (after accounting for age and sex effects) is due to additive genetic effects. This corresponds to 48-75 % of the total phenotypic variance. Our results demonstrate that normal, population-level variation in cortical microstructure is significantly influenced by genes. As a critical mediator of crack behavior in bone cortex, intracortical microstructural variation provides another mechanism through which genetic variation may affect fracture risk.

Havill LM; Allen MR; Harris JA; Levine SM; Coan HB; Mahaney MC; Nicolella DP

2013-08-01

243

Do birds and beetles show similar responses to urbanization?  

UK PubMed Central (United Kingdom)

To date, the vast majority of studies in urban areas have been carried out on birds, yet it is not known whether the responses of birds to urbanization are congruent with those of other taxa. In this paper, we compared the responses of breeding birds and carabid beetles to urbanization, specifically asking whether the emerging generalizations of the effects of extreme levels of urbanization on birds (declines in total species richness and the richness of specialist species, increases in total abundance and the abundances of native generalist and introduced species, and community simplification, including increasing similarity) could also be applied to ground beetles. We also directly tested for congruence between birds and ground beetles using correlations between variables describing bird and beetle community structure and correlations between bird and beetle distance matrices describing community dissimilarity between pairs of sampling locations. Breeding bird and carabid beetle community data were collected in Ottawa, Ontario, and Gatineau, Quebec, Canada, in two groups of sites: developed sites representing the predictor variable within-site housing density, and forested sites adjacent to development representing the predictor variable neighboring housing density (each site was 0.25 km2). Breeding birds and carabid beetles do not respond similarly to increasing within-site housing density but do exhibit some similar responses to increasing neighboring housing density. Birds displayed strong declines in diversity, compositional changes, and community simplification in response to increasing within-site housing density. Forest and introduced species of birds and beetles responded similarly to increasing housing density within a site, but responses of overall diversity and open-habitat species richness and patterns of community simplification differed between birds and beetles. Increasing neighboring housing density resulted in increases in the abundances of introduced birds and introduced beetles and similar patterns of community simplification in both taxa. To better understand and mitigate the effects of urbanization on biodiversity, we suggest that, in addition to the responses of birds, future research should focus on the responses of other taxa in the urban matrix.

Gagné SA; Fahrig L

2011-09-01

244

Latest results from GAMS  

International Nuclear Information System (INIS)

Some of the latest results of the GAMS Collaboration are reviewed. The fo(1590) has been observed in central collisions, adding support to its glueball nature. Evidence has been found for an exotic 1-+ meson M(1405) decaying into ? degree? in the exclusive reaction ?-p ? M(1405)n at 100 GeV/c. New data are presented on the reaction ?-p ? ??n at 38 GeV/c showing the presence of two tensor mesons. 22 references, 8 figures

1988-09-01

245

MCP: the Danish results  

Energy Technology Data Exchange (ETDEWEB)

In this paper we will show how Danish companies use the motor challenge programme (MCP). We will present case studies from a large amount of businesses. We will present company results due to the use of the different types of guidelines. Also we will try to show how MCP works in corporation with quality management, environmental management systems and others company management systems. At last we will present how we promote MCP in Denmark and present our action plan for the goal of 100 more MCP partners in Denmark. Case studies. Through a number of cases, we will present result from several Danish companies working with MCP. We present the difference in working with MCP in small businesses and in larger businesses. Also presenting new ways of working with MCP. As a part of these studies we will present how the Danish company York Refrigeration saves 250 MWh by using MCP as basis for a leak check programme. How Baby Dan A/S optimize ventilations plants by nearly 25% and other very interesting studies. (orig.)

Weldingh, P. [Lokalenergi Handel A/S, Viby J (Denmark)

2005-07-01

246

Estimating the Cost of No-Shows and Evaluating the Effects of Mitigation Strategies.  

Science.gov (United States)

OBJECTIVE: . To measure the cost of nonattendance ("no-shows") and benefit of overbooking and interventions to reduce no-shows for an outpatient endoscopy suite. METHODS: . We used a discrete-event simulation model to determine improved overbooking scheduling policies and examine the effect of no-shows on procedure utilization and expected net gain, defined as the difference in expected revenue based on Centers for Medicare & Medicaid Services reimbursement rates and variable costs based on the sum of patient waiting time and provider and staff overtime. No-show rates were estimated from historical attendance (18% on average, with a sensitivity range of 12%-24%). We then evaluated the effectiveness of scheduling additional patients and the effect of no-show reduction interventions on the expected net gain. RESULTS: . The base schedule booked 24 patients per day. The daily expected net gain with perfect attendance is $4433.32. The daily loss attributed to the base case no-show rate of 18% is $725.42 (16.4% of net gain), ranging from $472.14 to $1019.29 (10.7%-23.0% of net gain). Implementing no-show interventions reduced net loss by $166.61 to $463.09 (3.8%-10.5% of net gain). The overbooking policy of 9 additional patients per day resulted in no loss in expected net gain when compared with the reference scenario. CONCLUSIONS: . No-shows can significantly decrease the expected net gain of outpatient procedure centers. Overbooking can help mitigate the impact of no-shows on a suite's expected net gain and has a lower expected cost of implementation to the provider than intervention strategies. PMID:23515215

Berg, Bjorn P; Murr, Michael; Chermak, David; Woodall, Jonathan; Pignone, Michael; Sandler, Robert S; Denton, Brian T

2013-03-20

247

Estimating the Cost of No-Shows and Evaluating the Effects of Mitigation Strategies.  

UK PubMed Central (United Kingdom)

OBJECTIVE: . To measure the cost of nonattendance ("no-shows") and benefit of overbooking and interventions to reduce no-shows for an outpatient endoscopy suite. METHODS: . We used a discrete-event simulation model to determine improved overbooking scheduling policies and examine the effect of no-shows on procedure utilization and expected net gain, defined as the difference in expected revenue based on Centers for Medicare & Medicaid Services reimbursement rates and variable costs based on the sum of patient waiting time and provider and staff overtime. No-show rates were estimated from historical attendance (18% on average, with a sensitivity range of 12%-24%). We then evaluated the effectiveness of scheduling additional patients and the effect of no-show reduction interventions on the expected net gain. RESULTS: . The base schedule booked 24 patients per day. The daily expected net gain with perfect attendance is $4433.32. The daily loss attributed to the base case no-show rate of 18% is $725.42 (16.4% of net gain), ranging from $472.14 to $1019.29 (10.7%-23.0% of net gain). Implementing no-show interventions reduced net loss by $166.61 to $463.09 (3.8%-10.5% of net gain). The overbooking policy of 9 additional patients per day resulted in no loss in expected net gain when compared with the reference scenario. CONCLUSIONS: . No-shows can significantly decrease the expected net gain of outpatient procedure centers. Overbooking can help mitigate the impact of no-shows on a suite's expected net gain and has a lower expected cost of implementation to the provider than intervention strategies.

Berg BP; Murr M; Chermak D; Woodall J; Pignone M; Sandler RS; Denton BT

2013-03-01

248

Impact and Fracture Toughness Properties of austempered Ductile Iron  

International Nuclear Information System (INIS)

Fracture characteristics of bainitic ductile iron transformed at various austempering temperatures and austempering times are evaluated by plane strain fracture toughness test and impact test. Impact tests were carried out on standard V-notch Charpy specimens at temperature range -100 to 350 degree C. Fracture toughness was measured using the short rod (SR) test procedure. Standard compact tension (CT) specimens of 25 mm thickness were also tested for reasons of comparison with SR results. Optical microscopy and scanning electron microscopy (SEM) were used for the examination of microstructure and fracture surface morphology, respectively. Austempering at 350 degree C resulted in the optimum impact energy and fracture toughness properties, whereas that at 270 degree C showed the inferior properties. Fractographic examination showed that different fracture mechanisms are associated with the different impact and fracture toughness levels obtained. 9 figs., 2 tabs

1994-01-01

249

Results of FFTBM Applications  

International Nuclear Information System (INIS)

In the past ten years a few methods were proposed to evaluate the accuracy of best-estimate thermal-hydraulic code predictions. One of the first and the most widely used was the Fast Fourier Transform Based Method (FFTBM). The FFTBM is easy to understand, convenient to use, user independent and it clearly indicates when simulation needs to be improved. The purpose of the paper is to review and analyze the applications of the FFTBM to the calculation analyses of International Standard Problems (ISP), Standard Problem Exercise (SPE) organized by CSNI or IAEA, and other experiment simulations. The FFTBM shows the measurement-prediction discrepancies in the frequency domain. The acceptability factor for code calculation was determined based on several hundreds code calculations. To analyze the applications the information on the time interval (end of transient), type of calculation (best calculation among participant to ISP or SPE, or best calculation performed by single organization), the code used, number of variables used, primary pressure accuracy and total accuracy (with standard and average weights) was gathered. The presented results of FFTBM applications lead us to the conclusion that the FFTBM is suitable method for accuracy quantification of thermal-hydraulic code calculations. It was mainly used for SB LOCA calculations. The results showed that the set criteria for total accuracy are valid only for primary system calculations while for severe accidents the method is presently limited to ranking of calculations. The results also showed that complexity of the transient is important factor influencing the total code accuracy. Generally more complex transient simulations are less accurate. When comparing the FFTBM method to other methods for quantitative assessment it seems that large number of applications is one of the important advantages for choosing existing FFTBM for accuracy assessment of code calculations. For single variable comparison also other powerful measures of accuracy may be used. This is very important for code developers. However even in this case it should be not forgotten that improving one parameter might deteriorate the other parameter or whole transient. Therefore the information on total accuracy is in favor to choose FFTBM. We suggest the presented applications to be a reference database for new users of FFTBM when to stop improvements to their simulation. Namely, this is one of the first attempts how to present best results of several calculations on one place. (author)

2002-01-01

250

Pressure locking test results  

Energy Technology Data Exchange (ETDEWEB)

The U.S. Nuclear Regulatory Commission (NRC), Office of Nuclear Regulatory Research, is funding the Idaho National Engineering Laboratory (INEL) in performing research to provide technical input for their use in evaluating responses to Generic Letter 95-07, {open_quotes}Pressure Locking and Thermal Binding of Safety-Related Power-Operated Gate Valves.{close_quotes} Pressure locking and thermal binding are phenomena that make a closed gate valve difficult to open. This paper discusses only the pressure locking phenomenon in a flexible-wedge gate valve; the authors will publish the results of their thermal binding research at a later date. Pressure locking can occur when operating sequences or temperature changes cause the pressure of the fluid in the bonnet (and, in most valves, between the discs) to be higher than the pressure on the upstream and downstream sides of the disc assembly. This high fluid pressure presses the discs against both seats, making the disc assembly harder to unseat than anticipated by the typical design calculations, which generally consider friction at only one of the two disc/seat interfaces. The high pressure of the bonnet fluid also changes the pressure distribution around the disc in a way that can further contribute to the unseating load. If the combined loads associated with pressure locking are very high, the actuator might not have the capacity to open the valve. The results of the NRC/INEL research discussed in this paper show that the relationship between bonnet pressure and pressure locking stem loads appears linear. The results also show that for this valve, seat leakage affects the bonnet pressurization rate when the valve is subjected to thermally induced pressure locking conditions.

DeWall, K.G.; Watkins, J.C.; McKellar, M.G.; Bramwell, D. [Idaho National Engineering Lab., Idaho Falls, ID (United States)] [and others

1996-12-01

251

Suffering by comparison: Twitter users' reactions to the Victoria's Secret Fashion Show.  

Science.gov (United States)

Social comparison theory suggests that evaluating the self in comparison with others (e.g., peers, celebrities, models) can influence body image. Experimental studies that have tested effects of viewing idealized images in the media often show that women feel worse about themselves after seeing images that illustrate the beauty ideal. Twitter presents a naturally occurring opportunity to study viewers' reactions. An analysis was conducted of 977 tweets sent immediately before and during the 2011 Victoria's Secret Fashion Show that reference the show. Although the majority were idiosyncratic remarks, many tweets contain evidence of upward social comparisons to the fashion models. There were tweets about body image, eating disorders, weight, desires for food or alcohol, and thoughts about self-harm. The results support social comparison theory, and suggest that vulnerable viewers could experience negative affect, or even engage in harmful behaviors, during or after viewing the show or others like it. PMID:23769929

Chrisler, Joan C; Fung, Kaitlin T; Lopez, Alexandra M; Gorman, Jennifer A

2013-06-13

252

Suffering by comparison: Twitter users' reactions to the Victoria's Secret Fashion Show.  

UK PubMed Central (United Kingdom)

Social comparison theory suggests that evaluating the self in comparison with others (e.g., peers, celebrities, models) can influence body image. Experimental studies that have tested effects of viewing idealized images in the media often show that women feel worse about themselves after seeing images that illustrate the beauty ideal. Twitter presents a naturally occurring opportunity to study viewers' reactions. An analysis was conducted of 977 tweets sent immediately before and during the 2011 Victoria's Secret Fashion Show that reference the show. Although the majority were idiosyncratic remarks, many tweets contain evidence of upward social comparisons to the fashion models. There were tweets about body image, eating disorders, weight, desires for food or alcohol, and thoughts about self-harm. The results support social comparison theory, and suggest that vulnerable viewers could experience negative affect, or even engage in harmful behaviors, during or after viewing the show or others like it.

Chrisler JC; Fung KT; Lopez AM; Gorman JA

2013-06-01

253

Consumer behavior towards show-room services of two wheelers with reference to Cuddalore district  

Directory of Open Access Journals (Sweden)

Full Text Available The study aims to find out the consumer behavior towards showroom service of two wheelers. A samples of 200 users selected randomly were studied. Standardized questionnaires were used to collect the data. The results reveal that users differ in consumer behaviour towards showroom services of two wheelers on the basis of satisfied random sampling. This study is made to describe the consumer satisfaction of two wheelers with respect to socio-economic characteristics as age, gender, occupation, family income, educational level and so on which is called descriptive study. The data were treated statistically using t-test, F-test and correlation. The result shows that students and employees are more satisfied about show room services. Demographic variables such as marital status, size of the family give significant effect related to show room services.

S.Saravanan; N.Panchanatham; S.Pragadeeswaran

2009-01-01

254

Results from Amanda  

International Nuclear Information System (INIS)

[en] In this report we present an update on the results from the Amanda-B10 detector which operated in 1997 at depths of 1500 to 2000 meters in the deep Antarctic ice. The goal of Amanda project is to search for extra-terrestrial neutrinos. As a precursor to such a search we have studied atmospheric neutrinos which act as a calibration source for the detector. The observation of atmospheric neutrinos at a rate consistent with Monte-Carlo predictions establishes Amanda-B10 as a neutrino telescope. The Amanda-B10 data has been searched for evidence of several classes of neutrinos and for magnetic monopoles. Searches for a diffuse high energy neutrino flux and for neutrinos in coincidence with gamma-ray bursts have been conducted. Preliminary data analyses show no excess of neutrinos has been found. (A.C.)

2001-01-01

255

Results from Amanda  

Energy Technology Data Exchange (ETDEWEB)

In this report we present an update on the results from the Amanda-B10 detector which operated in 1997 at depths of 1500 to 2000 meters in the deep Antarctic ice. The goal of Amanda project is to search for extra-terrestrial neutrinos. As a precursor to such a search we have studied atmospheric neutrinos which act as a calibration source for the detector. The observation of atmospheric neutrinos at a rate consistent with Monte-Carlo predictions establishes Amanda-B10 as a neutrino telescope. The Amanda-B10 data has been searched for evidence of several classes of neutrinos and for magnetic monopoles. Searches for a diffuse high energy neutrino flux and for neutrinos in coincidence with gamma-ray bursts have been conducted. Preliminary data analyses show no excess of neutrinos has been found. (A.C.)

Hill, G.C. [Wisconsin Univ., Madison, WI (United States). Dept. of Physics

2001-07-01

256

Children showing labial palatine fissures and a low weight at birth in central hearing tests  

Directory of Open Access Journals (Sweden)

Full Text Available Introduction: Neurological or sensorial alterations, some of which are peripheral and/or central hearing alterations, are focused on both the people showing a low weight at birth (LW) and the presence of craniofacial malformation, such as labial palatine fissure (LPF). Objective: Check and compare the results of hearing processing tests, Dichotic Listening Test (DLT) and Auditory Fusion Test-Revised (AFT-R) in LPF and LW children with those in children born with a normal weight and showing no LPF. Methods: Retrospective comparative study with 73 records, in which sex, weight at birth, LPF presence/absence and the DLT and AFT-R results were verified. Three groups were formed based on the analysis of weight at birth and FLP absence/presence. Results: For DLT, the Covariance Analysis did not present any difference between the groups and sexes; however the age covariant showed a statistically significant relation. Fort AFT-R, there was no difference between groups, sexes and ages. Conclusion: LPF AND LW children, however statistically insignificant, showed bigger modifications in the hearing processing tests in comparison with isolated LPF children and with children having neither this craniofacial malformation nor LW. It must as well be emphasized that an increase in age enhanced DDT performance.

Araújo, Letícia Maria Martins; Lauris, José Roberto Pereira; Feniman, Mariza Ribeiro

2011-01-01

257

Discourse Representations of Migrants in Political Talk-Shows in Romania  

Directory of Open Access Journals (Sweden)

Full Text Available In this study, we analyse the way in which talk-shows in Romania build upon intra-EU migration as a public issue. According to one of the research hypotheses, the topic of new migration is strategically used in the public environment, determining the taking of positions, agendas and forms of institutionalisation. The semiotic and discourse analysis of a corpus of political talk-shows broadcast in the period 2010-2011 by Romanian TV stations specialising in news and socio-political debates highlights discourse strategies that are relevant for the media construction of public issues in talk-shows. The article shows that in talks-shows migrants are represented "globally", from the perspective of categories of persons that can contribute to a competitive national image. Migrants become visible through their performances in the host country and, as a result, the moral distance from them becomes apparent through a politics of visibility (hence the visibility of mythical migration, of high-performance migration, etc.). Talk-shows do not present the issue of the Diaspora experience, namely of the position of migrants with respect to forms of otherness, cooperation or solidarity.

CAMELIA BECIU

2013-01-01

258

Beth Israel/Harvard study finds new immune therapy shows promise in kidney cancer  

Science.gov (United States)

An antibody that helps a person’s own immune system battle cancer cells shows increasing promise in reducing tumors in patients with advanced kidney cancer, according to researchers at Beth Israel Deaconess Medical Center. The results of an expanded Phase 1 trial presented at the American Society of Clinical Oncology’s annual conference in Chicago, showed that some patients treated with a fully human monoclonal antibody developed by Bristol Myers Squibb had a positive response to the effort by the agent, BMS-936558, to prolong the immune system’s efforts to fight off renal cell carcinoma without some of the debilitating side effects common to earlier immunotherapies.

259

Overview of cold fusion results.  

Science.gov (United States)

According to recent experimental results, some metals like palladium or titanium, filled with deuterium, seem to show phenomena as heat production, tritium and/or neutron generation ascribable to cold nuclear fusion reactions. One of the major difficultie...

F. De Marco

1990-01-01

260

Adolescents with Autism Spectrum Disorder Show a Circumspect Reasoning Bias Rather than 'Jumping-to-Conclusions'  

UK PubMed Central (United Kingdom)

People with autism spectrum disorders (ASD) often take longer to make decisions. The Autism-Psychosis Model proposes that people with autism and psychosis show the opposite pattern of results on cognitive tasks. As those with psychosis show a jump-to-conclusions reasoning bias, those with ASD should show a circumspect reasoning bias. Jumping-to-conclusions was assessed in a sample of 20 adolescents with ASD and 23 age-matched controls using the jumping-to-conclusions beads task. Both groups demonstrated equivalent levels of confidence in decision-making, however the ASD group required more beads than controls before making their decision. Furthermore, there was a positive correlation between the beads required and degree of autism symptoms. Consistent with the Autism-Psychosis Model, a more circumspect reasoning bias was evident in ASD.

Brosnan M; Chapman E; Ashwin C

2013-09-01

 
 
 
 
261

Adaptively evolved yeast mutants on galactose show trade-offs in carbon utilization on glucose.  

UK PubMed Central (United Kingdom)

Adaptive evolution offers many opportunities in metabolic engineering; however, several constraints still exist as evolutionary trade-offs may impose collateral cost to obtain new traits. The application of adaptive evolution for strains development could be further improved by elucidating the molecular mechanisms. In this study, adaptively evolved yeast mutants with improved galactose utilization ability showed impaired glucose utilization. The molecular genetic basis of this trade-off was investigated using a systems biology approach. Transcriptional and metabolic changes resulting from the improvement of galactose utilization were found maintained during growth on glucose. Moreover, glucose repression related genes showed conserved expression patterns during growth on both sugars. Mutations in the RAS2 gene that were identified as beneficial for galactose utilization in evolved mutants exhibited significant correlation with attenuation of glucose utilization. These results indicate that antagonistic pleiotropy is the dominant mechanism in the observed trade-off, and it is likely realized by changes in glucose signaling.

Hong KK; Nielsen J

2013-03-01

262

Bacteriocin-like substance from Bacillus amyloliquefaciens shows remarkable inhibition of Acanthamoeba polyphaga.  

Science.gov (United States)

The effectiveness of a bacteriocin-like substance (BLS) produced by Bacillus amyloliquefaciens was tested against Acanthamoeba polyphaga strains, and its cytotoxic potential on Vero cells was investigated. Amebicidal activity of the purified BLS was tested by plate bioassays with concentrations ranging from 12.5 to 6,400 AU mL(-1). Damage to A. pholyphaga cells was monitored using an inverted microscope and counted in a Fuchs-Rosenthal chamber after 24, 48, and 72 h. According to the results obtained, the BLS showed remarkable amebicidal and amebostatic effect on A. polyphaga and showed no cytotoxicity on the Vero cells. These results may have great relevance in the development of new acanthamoebicidal compounds. PMID:20967460

Benitez, Lisianne Brittes; Caumo, Karin; Brandelli, Adriano; Rott, Marilise Brittes

2010-10-22

263

Bacteriocin-like substance from Bacillus amyloliquefaciens shows remarkable inhibition of Acanthamoeba polyphaga.  

UK PubMed Central (United Kingdom)

The effectiveness of a bacteriocin-like substance (BLS) produced by Bacillus amyloliquefaciens was tested against Acanthamoeba polyphaga strains, and its cytotoxic potential on Vero cells was investigated. Amebicidal activity of the purified BLS was tested by plate bioassays with concentrations ranging from 12.5 to 6,400 AU mL(-1). Damage to A. pholyphaga cells was monitored using an inverted microscope and counted in a Fuchs-Rosenthal chamber after 24, 48, and 72 h. According to the results obtained, the BLS showed remarkable amebicidal and amebostatic effect on A. polyphaga and showed no cytotoxicity on the Vero cells. These results may have great relevance in the development of new acanthamoebicidal compounds.

Benitez LB; Caumo K; Brandelli A; Rott MB

2011-03-01

264

Adaptively evolved yeast mutants on galactose show trade-offs in carbon utilization on glucose  

DEFF Research Database (Denmark)

Adaptive evolution offers many opportunities in metabolic engineering; however, several constraints still exist as evolutionary trade-offs may impose collateral cost to obtain new traits. The application of adaptive evolution for strains development could be further improved by elucidating the molecular mechanisms. In this study, adaptively evolved yeast mutants with improved galactose utilization ability showed impaired glucose utilization. The molecular genetic basis of this trade-off was investigated using a systems biology approach. Transcriptional and metabolic changes resulting from the improvement of galactose utilization were found maintained during growth on glucose. Moreover, glucose repression related genes showed conserved expression patterns during growth on both sugars. Mutations in the RAS2 gene that were identified as beneficial for galactose utilization in evolved mutants exhibited significant correlation with attenuation of glucose utilization. These results indicate that antagonistic pleiotropy is the dominant mechanism in the observed trade-off, and it is likely realized by changes in glucose signaling. © 2013 Elsevier Inc.

Hong, Kuk-Ki; Nielsen, Jens

2013-01-01

265

Report on Results 2000  

Energy Technology Data Exchange (ETDEWEB)

This report discusses work being carried out in Norway to promote energy efficiency and the production of new renewable energy. An overall review of the quantifiable results of last year's activities at national level is available. It will serve to initiate an annual reporting tradition. The report represents a step towards an ongoing process for improved targeting and management of national efforts. During the course of the year 2000, NVE has evaluated and adjusted its activities and established a system involving indicators and reporting procedures. It is also important to take notice of the long-term work being undertaken to influence people's attitudes, even though this work is difficult to assess. NVE is investing in i.a. measures aimed at children and young people. Apart from directly influencing future energy users, this investment is also having an effect due to the children's encouragement of their parents to engage in more energy and environment-friendly behaviour. Published in 2000, the IEA report ''Trends in Norwegian Stationary Energy Use'' shows that total Norwegian energy consumption per GDP is not much higher than in other IEA countries, when adjusted for cold climate and industrial structure. However, Norwegians do stand out as intensive users of electricity. The IEA report shows a reduction of 10 TWh in energy usage when compared to the projected post 1990 figures. Energy efficiency activities have contributed towards this reduction. However, the potential for a more rational use of energy in Norway is still substantial and well documented. Based on experience most enterprises could save around 10% of energy used just by making changes to their operations, i.e. without major investments. Furthermore, the potential is growing because of massive technological developments in respect of energy usage, production and distribution. With this in mind, it is necessary to take full advantage of the extensive knowledge base regarding new renewable energy sources that is available through Nordic cooperation. During the course of the year a new energy body will be established to assume responsibility for initiatives encouraging more rational energy usage and more environment-friendly energy production. When this energy body commences operations next year, it will have a solid foundation on which to build further. It will inherit a well-founded system and an efficient structure. The results achieved during the year 2000 show savings in energy efficiency and the production of new renewable energy of 720 GWh. The gains could be even greater with clearly defined target-driven management. Due to internationalisation, Norway now has to deal with problems to which little attention was previously paid. All energy production has negative environmental co sequences. It is becoming increasingly obvious that we all need to contribute to limiting the damaging effects, while at the same time the international community needs to take the initiative in harmonizing measures which can result in a more sustainable and environment-friendly direction.

NONE

2001-07-01

266

Entropy Calculation of Reversible Mixing of Ideal Gases Shows Absence of Gibbs Paradox  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract: We consider the work of reversible mixing of ideal gases using a real process. Now assumptions were made concerning infinite shifts, infinite number of cycles and infinite work to provide an accurate calculation of entropy resulting from reversible mixing of ideal gases. We derived an equation showing the dependence of this entropy on the difference in potential of mixed gases, which is evidence for the absence of Gibbs' paradox.

Vasili Tatarin; Oleg Borodiouk

1999-01-01

267

Hunted woolly monkeys (Lagothrix poeppigii) show threat-sensitive responses to human presence.  

Science.gov (United States)

Responding only to individuals of a predator species which display threatening behaviour allows prey species to minimise energy expenditure and other costs of predator avoidance, such as disruption of feeding. The threat sensitivity hypothesis predicts such behaviour in prey species. If hunted animals are unable to distinguish dangerous humans from non-dangerous humans, human hunting is likely to have a greater effect on prey populations as all human encounters should lead to predator avoidance, increasing stress and creating opportunity costs for exploited populations. We test the threat sensitivity hypothesis in wild Poeppigi's woolly monkeys (Lagothrix poeppigii) in Yasuní National Park, Ecuador, by presenting human models engaging in one of three behaviours "hunting", "gathering" or "researching". These experiments were conducted at two sites with differing hunting pressures. Visibility, movement and vocalisations were recorded and results from two sites showed that groups changed their behaviours after being exposed to humans, and did so in different ways depending on the behaviour of the human model. Results at the site with higher hunting pressure were consistent with predictions based on the threat sensitivity hypothesis. Although results at the site with lower hunting pressure were not consistent with the results at the site with higher hunting pressure, groups at this site also showed differential responses to different human behaviours. These results provide evidence of threat-sensitive predator avoidance in hunted primates, which may allow them to conserve both time and energy when encountering humans which pose no threat. PMID:23614003

Papworth, Sarah; Milner-Gulland, E J; Slocombe, Katie

2013-04-16

268

Areva - 2011 Annual results  

International Nuclear Information System (INIS)

[en] Areva's backlog established at 45.6 billion euros at the end of 2011, significantly increasing at the end of a year marked by the Fukushima accident, confirms the commercial dynamism of the group alongside its customers and reinforces the visibility on its future business level. In a difficult context, the slight decline in revenue in 2011 demonstrates the robustness of Areva's integrated model, resting mainly on recurring business generated in relation to Areva's customers' nuclear installed base, and benefiting from the development of Areva's renewable energies operations. Free operating cash flow before tax, although down over the whole year in 2011, improved in the second half, showing the first effects of Areva's stronger focus on cash generation and debt management. After the success of Areva's bond issue in September 2011, the Group's liquidity remains high at the end of 2011. The Areva teams are now dedicating all of their efforts to the deployment of the 'Action 2016' strategic action plan, which had already yielded its first positive results at the end of 2011, with an improvement in the cost structure of Areva's operations, an increase in order intake, and the launch of several disposals of minority interests. Summary of the 2011 financial results: - Backlog: euro 45.6 bn, +3.1% vs. 2010, i.e +6.7% over 3 months; - Revenue: euro 8.872 bn, i.e -2.6% vs. 2010; - Operating income: - euro 1.923 bn; - Net income attributable to equity owners of the parent: - euro 2.424 bn; - EBITDA: euro 1.068 bn ( euro 420 m excluding Siemens impact); - Free operating cash flow before tax: - euro 2.397 bn (- euro 1.366 bn excluding Siemens impacts), improvement over the second half; - Decrease in net debt of euro 124 m for the year; - Significant drop in general and administrative expenses, with a noticeable reduction between the first and the second half; - Launch of several disposals of minority interests

2012-01-01

269

Possible distortion of autoradiographic results  

Energy Technology Data Exchange (ETDEWEB)

The effect of radioactive labelling (H/sup 3/-thymidine) on the infusorian division is studied. The presented results show that introduction of labelled compounds results in accelerating infusorian cell division v. Thorough investigation of labelled compound effect with low activity on the parameters of cell division and the search of methods to eliminate distortions able to appear in autoradiographic experiments is expedient.

Kozlov, A.A.; Tumanushvili, G.D. (AN Gruzinskoj SSR, Tbilisi. Inst. Ehksperimental' noj Morfologii)

1980-01-01

270

Degradation of impact fracture during accelerated aging of weld metal on microalloyed steel  

International Nuclear Information System (INIS)

[en] The effect of accelerated aging on the toughness and fracture of the longitudinal weld metal on an API5L-X52 line pipe steel was evaluated by Charpy V-notch impact test, fracture analysis and transmission electron microscopy. Aging was performed at 250 degree centigrade for 100 to 1000 h. The impact results indicated a significant reduction in the fracture energy and impact toughness as a function of aging time, which were achieved by the scanning electron microscope fractography that showed a decrease in the vol fraction of microvoids by Charpy ductile failure with the aging time, which favored the brittle fracture by transgranular cleavage. The minimum vol fraction of microvoids was reached at 500 h due to the peak aged. The microstructural analysis indicated the precipitation of transgranular iron nano carbides in the aged specimens, which was related to the deterioration of toughness and change in the ductile to brittle behavior. (Author) 15 refs

2008-01-01

271

The effect of aging at 343/degree/C on type 308 stainless steel welds  

Energy Technology Data Exchange (ETDEWEB)

Three nominally 25-mm (1-in) thick shielded metal-arc welds were prepared from 304L base plate with 308 filler material, to obtain three different ferrite levels (4, 8, and 12 %). Portions of these welds were then aged at 343/degree/C for 3000, 10000, and 20000 hours. Charpy V-notch and tensile specimens were taken from the welds. The tensile results were similar for all the specimens and showed little effect of aging on either the yield or ultimate tensile strengths. The Charpy impact properties of the higher ferrite content materials were significantly degraded by these agings, with larger decreases in the impact energy with increased aging time. The microstructures of the welds were examined by metallography and transmission electron microscopy, and the fracture surfaces were examined by scanning electron microscopy. The changes in the mechanical properties and the fractography are discussed in light of the observed changes in the microstructure. 3 refs., 3 figs., 2 tabs.

Alexander, D.J.; Alexander, K.B.; Nanstad, R.K.

1989-01-01

272

The effect of aging at 343/degree/C on type 308 stainless steel welds  

International Nuclear Information System (INIS)

Three nominally 25-mm (1-in) thick shielded metal-arc welds were prepared from 304L base plate with 308 filler material, to obtain three different ferrite levels (4, 8, and 12 %). Portions of these welds were then aged at 343/degree/C for 3000, 10000, and 20000 hours. Charpy V-notch and tensile specimens were taken from the welds. The tensile results were similar for all the specimens and showed little effect of aging on either the yield or ultimate tensile strengths. The Charpy impact properties of the higher ferrite content materials were significantly degraded by these agings, with larger decreases in the impact energy with increased aging time. The microstructures of the welds were examined by metallography and transmission electron microscopy, and the fracture surfaces were examined by scanning electron microscopy. The changes in the mechanical properties and the fractography are discussed in light of the observed changes in the microstructure. 3 refs., 3 figs., 2 tabs.

273

Degradation of impact fracture during accelerated aging of weld metal on microalloyed steel; Degradacion de la tenacidad al impacto durante el envejecimiento acelerado de soldadura en acero microaleado  

Energy Technology Data Exchange (ETDEWEB)

The effect of accelerated aging on the toughness and fracture of the longitudinal weld metal on an API5L-X52 line pipe steel was evaluated by Charpy V-notch impact test, fracture analysis and transmission electron microscopy. Aging was performed at 250 degree centigrade for 100 to 1000 h. The impact results indicated a significant reduction in the fracture energy and impact toughness as a function of aging time, which were achieved by the scanning electron microscope fractography that showed a decrease in the vol fraction of microvoids by Charpy ductile failure with the aging time, which favored the brittle fracture by transgranular cleavage. The minimum vol fraction of microvoids was reached at 500 h due to the peak aged. The microstructural analysis indicated the precipitation of transgranular iron nano carbides in the aged specimens, which was related to the deterioration of toughness and change in the ductile to brittle behavior. (Author) 15 refs.

Vargas-Arista, B.; Hallen, J. M.; Albiter, A.; Angeles-Chavez, C.

2008-07-01

274

Evaluating mechanical properties of hybrid laser arc girth welds  

Energy Technology Data Exchange (ETDEWEB)

Hybrid laser arc welding (HLAW) is a promising new process for making girth welds on steel pipelines. This study investigated the mechanical properties of overmatched X80 and X100 pipeline steel girth welds made using the HLAW process. The testing of this process was conducted on NPS36 pipes of 10.4 mm and 14.3 mm thickness, respectively. Various weld positions were produced on X80 and X100 pipes. Laser inspection data were collected during the whole welding process. Also standard tests for girth welds, Charpy V-notch impact tests, CTOD tests, all weld metal (AWM) tension tests, were carried out. The results showed that the fracture transition temperature is higher at the 3 and 9 o'clock positions than at the 9 and 12 o'clock positions. The effect of clock position on fracture toughness is currently being explored; a modified CTOD has been developed to reduce the possibility of crack deviation.

Pussegoda, L. N.; Begg, D.; Holdstock, R.; Jodoin, A. [BMT Fleet Technology Ltd Techonology, Kanata, ON, (Canada); Ligh, K.; Rondeau, D. [Appliead Thermal Sciences Inc., Sanford, ME, (United States); Hansen, E. [ESAB, Florence, SC, (United States)

2010-07-01

275

Field girth weld HAZ toughness improvement - X80/grade 550  

Energy Technology Data Exchange (ETDEWEB)

Heat affected zone (HAZ) material is a big concern in the pipeline industry because of the alteration of the microstructure. This study investigates the chemical composition factors which optimize field weldability by enhancing HAZ toughness. Four X80/Grade 550 pipeline alloys were studied. Robotic welding methods were used to make welded skelp and flattened pipe welds. Charpy V-notch (CVN) and crack tip opening displacement (CTOD) tests were performed to observe fracture resistance in the HAZ. The HAZ microstructure was studied using optical and Gleeble thermo-mechanical microscopy. The results showed that the HAZ toughness was better for material chemistries that produce lower phase transformation temperatures. Lower phase transformation temperature produced better microstructural phases, with finer prior austenite grain size. Phase transformation temperature and prior austenite grain size were related to the carbon or carbon equivalent content of the material.

Collins, L.E.; Penniston, C. [Evraz Inc. NA, Regina, SK, (Canada)

2010-07-01

276

Estimation of Fracture Toughness Degradation of High Temperature Materials by Nonlinear Acoustic Effects  

Energy Technology Data Exchange (ETDEWEB)

In order to develop an ultrasonic evaluation method for properties degradation of high temperature materials, a number of Cr-Mo-V steel samples were heat-treated and their damage mechanism was examined. Ultrasonic parameters such as velocity, attenuation, and more recently developed nonlinear acoustic parameter were measured. The nonlinear acoustic parameter was found to be most sensitive to material degradation mainly attributed to the precipitation of impurities in grain boundaries. When compared to the electrical resistivity results, the nonlinear parameters showed similar behavior. There existed a relatively good correlation between the nonlinear parameter and the fracture appearance transition temperature (FATT) obtained by Charpy V-notch impact test. Based on the relationship between the FATT and the fracture toughness (K{sub IC}), correlation between the nonlinear parameter and K{sub IC} was established

Jeong, Hyun Jo [Wonkwang University, Iksan (Korea, Republic of); Nahm, Seung Hoon [Korea Research institute of Standards and Science, Daejeon (Korea, Republic of); Jhang, Kyung Young [Hanyang University, Seoul (Korea, Republic of); Nam, Young Hyun [Korea Heavy Industries, Changwon (Korea, Republic of)

2000-10-15

277

Estimation of Fracture Toughness Degradation of High Temperature Materials by Nonlinear Acoustic Effects  

International Nuclear Information System (INIS)

In order to develop an ultrasonic evaluation method for properties degradation of high temperature materials, a number of Cr-Mo-V steel samples were heat-treated and their damage mechanism was examined. Ultrasonic parameters such as velocity, attenuation, and more recently developed nonlinear acoustic parameter were measured. The nonlinear acoustic parameter was found to be most sensitive to material degradation mainly attributed to the precipitation of impurities in grain boundaries. When compared to the electrical resistivity results, the nonlinear parameters showed similar behavior. There existed a relatively good correlation between the nonlinear parameter and the fracture appearance transition temperature (FATT) obtained by Charpy V-notch impact test. Based on the relationship between the FATT and the fracture toughness (KIC), correlation between the nonlinear parameter and KIC was established

2000-01-01

278

Uma aproximação analí­tica do formato televisual do reality show Big Brother  

Directory of Open Access Journals (Sweden)

Full Text Available O trabalho apresenta alguns resultados de uma pesquisa comparada sobre o funcionamento semiótico de um formato televisivo global em duas de suas produções locais, Rio de la Plata e Brasil, nos anos 2001 e 2002. Através da perspectiva sociossemiótica baseada no modelo de Peirce, procura-se analisar os elementos próprios da significação do formato e de sua contextualização local. Descreve-se o reality show Big Brother como uma melocrônica dos bastidores da interação humana, em atenção aos componentes sí­gnicos centrais do formato, isto é, í­ndices e í­cones, que emergem na encenação televisual do face a face cotidiano. A contemplação turí­stica da ordem de interação ou do âmbito da sociabilidade permite compreender mudanças nas formas sociais que vão muito além do reduzido espaço do reality show glocal da Endemol, p.ex. no discurso eleitoral televisivo brasileiro. Palavras chave reality show, semiótica triádica, gênero hí­brido, sociabilidade. Abstract The article presents some results of a comparative research on the semiotic functioning of a global television genre in two of its local productions, that of the River Plate and that of Brazil, in the years 2001 and 2002. Through a sociosemiotic perspective based on the model of C. S. Peirce, the text accounts for the specific elements of signification of the format and of its local contextualization. The Big Brother reality show is deemed to be a hybrid genre, namely, a melochronicle of the backstage of human interaction, on account of the basic sign components of this TV format, i.e., indexes and icons, which emerge in the televisual staging of everyday face to face encounters. A tourist-like contemplation of the order of interaction or sociability realm allows us to understand changes in the social forms that reach far beyond the limited realm of the glocal Endemol reality show, for instance, in the Brazilian television political campaign. Key words reality show; triadic semiotic; hybrid genre; social interaction.

Fernando Andacht

2008-01-01

279

Clove (Syzygium aromaticum Linn) extract rich in eugenol and eugenol derivatives shows bone-preserving efficacy.  

Science.gov (United States)

This study examined the efficacy of hydroalcoholic extract of dried clove buds, which is rich in phenolic compounds namely eugenol and eugenol derivatives (precursors of flavones, isoflavones and flavonoids), on different primary and secondary osteoporotic marker changes in an ovariectomised (OVX) rat model of osteoporosis. Female Wistar rats were randomly divided into three groups: sham-operated control (A), OVX (B) and OVX plus 50% hydroalcoholic extract of dried clove buds for 4 weeks (C). Results indicated that, compared to control, serum alkaline phosphatase (AP; 48.25%, p?clove buds. Results of bone density, bone mineral content, bone tensile strength and histological analysis also showed similar trend of results, which supported initial observations of this study. It is proposed that hydroalcoholic extract of dried clove buds has bone-preserving efficacy against hypogonadal osteoporosis. PMID:21711176

Karmakar, Subhra; Choudhury, Monalisa; Das, Asankur Sekhar; Maiti, Anasuya; Majumdar, Sangita; Mitra, Chandan

2011-06-28

280

Benign paroxysmal positional vertigo showing sequential translations of four types of nystagmus.  

UK PubMed Central (United Kingdom)

OBJECTIVE: We report a case of benign paroxysmal positional vertigo (BPPV) showing sequential translation of four types of nystagmus and discuss its pathophysiology. METHODS: The case was 65-year-old female. We analyzed her nystagmus three-dimensionally. RESULTS: At the first visit, she showed vertical-torsio nystagmus of the posterior canal type of BPPV (P-BPPV) and subsequently showed recently reported geotropic nystagmus with a long time constant. Two weeks later, she showed apogeotropic nystagmus of the horizontal canal type of BPPV (AH-BPPV) and subsequently a geotropic nystagmus with a short time constant of the horizontal canal type of BPPV (GH-BPPV). CONCLUSIONS: Three kind of nystagmus, namely P-BPPV, AH-BPPV and GH-BPPV can be explained by the otoconial debris hypothesis of the same ear. Finally, the recently reported geotropic nystagmus with a long time constant may be explained by a reversible lesion such as the denatured cupula or utricular imbalance of the same ear.

Imai T; Takeda N; Uno A; Horii A; Kitahara T; Nishiike S; Higashi-Shingai K; Inohara H

2012-10-01

 
 
 
 
281

Syndromes dominated by apraxia of speech show distinct characteristics from agrammatic PPA.  

UK PubMed Central (United Kingdom)

OBJECTIVE: We assessed whether clinical and imaging features of subjects with apraxia of speech (AOS) more severe than aphasia (dominant AOS) are more similar to agrammatic primary progressive aphasia (agPPA) or to primary progressive AOS (PPAOS). METHODS: Sixty-seven subjects (PPAOS = 18, dominant AOS = 10, agPPA = 9, age-matched controls = 30) who all had volumetric MRI, diffusion tensor imaging, F18-fluorodeoxyglucose and C11-labeled Pittsburgh compound B (PiB)-PET scanning, as well as neurologic and speech and language assessments, were included in this case-control study. AOS was classified as either type 1, predominated by sound distortions and distorted sound substitutions, or type 2, predominated by syllabically segmented prosodic speech patterns. RESULTS: The dominant AOS subjects most often had AOS type 2, similar to PPAOS. In contrast, agPPA subjects most often had type 1 (p = 0.01). Both dominant AOS and PPAOS showed focal imaging abnormalities in premotor cortex, whereas agPPA showed widespread involvement affecting premotor, prefrontal, temporal and parietal lobes, caudate, and insula. Only the dominant AOS and PPAOS groups showed midbrain atrophy compared with controls. No differences were observed in PiB binding across all 3 groups, with the majority being PiB negative. CONCLUSION: These results suggest that dominant AOS is more similar to PPAOS than agPPA, with dominant AOS and PPAOS exhibiting a clinically distinguishable subtype of progressive AOS compared with agPPA.

Josephs KA; Duffy JR; Strand EA; Machulda MM; Senjem ML; Lowe VJ; Jack CR Jr; Whitwell JL

2013-07-01

282

Alzheimer's-associated A? oligomers show altered structure, immunoreactivity and synaptotoxicity with low doses of oleocanthal  

International Nuclear Information System (INIS)

It now appears likely that soluble oligomers of amyloid-?1-42 peptide, rather than insoluble fibrils, act as the primary neurotoxin in Alzheimer's disease (AD). Consequently, compounds capable of altering the assembly state of these oligomers (referred to as ADDLs) may have potential for AD therapeutics. Phenolic compounds are of particular interest for their ability to disrupt A? oligomerization and reduce pathogenicity. This study has focused on oleocanthal (OC), a naturally-occurring phenolic compound found in extra-virgin olive oil. OC increased the immunoreactivity of soluble A? species, when assayed with both sequence- and conformation-specific A? antibodies, indicating changes in oligomer structure. Analysis of oligomers in the presence of OC showed an upward shift in MW and a ladder-like distribution of SDS-stable ADDL subspecies. In comparison with control ADDLs, oligomers formed in the presence of OC (A?-OC) showed equivalent colocalization at synapses but exhibited greater immunofluorescence as a result of increased antibody recognition. The enhanced signal at synapses was not due to increased synaptic binding, as direct detection of fluorescently-labeled ADDLs showed an overall reduction in ADDL signal in the presence of OC. Decreased binding to synapses was accompanied by significantly less synaptic deterioration assayed by drebrin loss. Additionally, treatment with OC improved antibody clearance of ADDLs. These results indicate oleocanthal is capable of altering the oligomerization state of ADDLs while protecting neurons from the synaptopathological effects of ADDLs and suggest OC as a lead compound for development in AD therapeutics.

2009-10-15

283

Two chitinase-like proteins abundantly accumulated in latex of mulberry show insecticidal activity  

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Full Text Available Abstract Background Plant latex is the cytoplasm of highly specialized cells known as laticifers, and is thought to have a critical role in defense against herbivorous insects. Proteins abundantly accumulated in latex might therefore be involved in the defense system. Results We purified latex abundant protein a and b (LA-a and LA-b) from mulberry (Morus sp.) and analyzed their properties. LA-a and LA-b have molecular masses of approximately 50 and 46 kDa, respectively, and are abundant in the soluble fraction of latex. Western blotting analysis suggested that they share sequence similarity with each other. The sequences of LA-a and LA-b, as determined by Edman degradation, showed chitin-binding domains of plant chitinases at the N termini. These proteins showed small but significant chitinase and chitosanase activities. Lectin RCA120 indicated that, unlike common plant chitinases, LA-a and LA-b are glycosylated. LA-a and LA-b showed insecticidal activities when fed to larvae of the model insect Drosophila melanogaster. Conclusions Our results suggest that the two LA proteins have a crucial role in defense against herbivorous insects, possibly by hydrolyzing their chitin.

Kitajima Sakihito; Kamei Kaeko; Taketani Shigeru; Yamaguchi Masamitsu; Kawai Fumiko; Komatsu Aino; Inukai Yoshihiro

2010-01-01

284

Two chitinase-like proteins abundantly accumulated in latex of mulberry show insecticidal activity.  

UK PubMed Central (United Kingdom)

BACKGROUND: Plant latex is the cytoplasm of highly specialized cells known as laticifers, and is thought to have a critical role in defense against herbivorous insects. Proteins abundantly accumulated in latex might therefore be involved in the defense system. RESULTS: We purified latex abundant protein a and b (LA-a and LA-b) from mulberry (Morus sp.) and analyzed their properties. LA-a and LA-b have molecular masses of approximately 50 and 46 kDa, respectively, and are abundant in the soluble fraction of latex. Western blotting analysis suggested that they share sequence similarity with each other. The sequences of LA-a and LA-b, as determined by Edman degradation, showed chitin-binding domains of plant chitinases at the N termini. These proteins showed small but significant chitinase and chitosanase activities. Lectin RCA120 indicated that, unlike common plant chitinases, LA-a and LA-b are glycosylated. LA-a and LA-b showed insecticidal activities when fed to larvae of the model insect Drosophila melanogaster. CONCLUSIONS: Our results suggest that the two LA proteins have a crucial role in defense against herbivorous insects, possibly by hydrolyzing their chitin.

Kitajima S; Kamei K; Taketani S; Yamaguchi M; Kawai F; Komatsu A; Inukai Y

2010-01-01

285

Testbeam Results of Endcap RPC's  

CERN Document Server

In this paper, results are presented from the beamtest in 2002 of the full-scale RE-2/2 prototype RPC chamber assembled in Pakistan. The results are mainly related with the efficiency, time resolution, and rate capability of this non-oiled RPC. The CMS collaboration has imposed strict criteria on the performance parameters for RPC's. These results show that prototype RPC's meet with all the CMS criteria and are suitable for installation in CMS detector.

Ahmed, Ijaz; Hoorani, Hafeez; Aftab, Zia; Jan, J. A; Shariq Khan, M; Solaija, Tariq

2006-01-01

286

Neutron spectra at different High Flux Isotope Reactor (HFIR) pressure vessel surveillance locations  

International Nuclear Information System (INIS)

[en] This project addresses the potential problem of radiation embrittlement of reactor pressure vessel (RPV) supports. Surveillance specimens irradiated at the High Flux Isotope Reactor (HFIR) at relatively low neutron flux levels (about 1.5E + 8 cm-2.s-1) and low temperatures (about 50 degrees C) showed embrittlement more rapidly than expected. Commercial power reactors have similar flux levels and temperatures at the level vessel support structures. The purposes of this work are to provide the neutron fluence spectra data that are needed to evaluate previously measured mechanical property changes in the HFIR, to explain the discrepancies in neutron flux levels between the nickel dosimeters and two other dosimeters, neptunium and beryllium, and to address any questions or peculiarities of the HFIR reactor environment. The current work consists of neutron and gamma transport calculations, dosimetry measurements, and least-squares logarithmic adjustment to obtain the best estimates for the neutron spectra and the related neutron exposure parameters. The results indicate that the fission rates in neptunium-237 (Np-237) and uranium-238 (U-238) and the helium production rates in beryllium-9 (Be-9) are dominated by photo-induced reactions. The displacements per atom rate for iron (dpa/s) from gamma rays is five times higher than the dpa/s from neutrons. The neutron fluxes in key 7, position 5 do not show any significant gradient in the surveillance capsule, but key 4 and key 2 showed differences in magnitude as well as in the shape of the spectrum. The stainless steel monitor in the V-notch of the Charpy specimens of the surveillance capsules is adequate to determine the neutron flux above 1.0 MeV at the desired V-notch location. Simultaneous adjustment of neutron and gamma fluxes with the measurements has been demonstrated and should avoid future problems with photo-induced reactions

1993-01-01

287

GFP-tagged E. coli shows bacterial distribution in mouse organs: pathogen tracking using fluorescence signal  

Science.gov (United States)

Purpose In vaccine efficacy evaluation, visualization of pathogens in whole organism at each time point would be able to reduce the consuming animals and provide the in vivo information within consistent background with identical organism. Materials and Methods Using IVIS spectrum whole live-animal imaging system, fluorescent intensity was optimized and visualized proportionately by concentrating Escherichia coli MC1061 strain which expresses GFP (E. coli-GFP) in BALB/C mice after injection. Results Local distribution of disseminated E. coli-GFP was traced in each organ by fluorescence. Detached organ showed more obvious fluorescent signal, and intestine showed strongest fluorescent signal. Conclusion This in vivo imaging method using GFP-tagged pathogen strain suggest quantified infected pathogens by fluorescence intensity in whole animals can provide the information about the localization and distribution after infection.

Park, Pil-Gu; Cho, Min-Hee; Rhie, Gi-eun; Jeong, Haeseul; Youn, Hyewon

2012-01-01

288

GFP-tagged E. coli shows bacterial distribution in mouse organs: pathogen tracking using fluorescence signal.  

UK PubMed Central (United Kingdom)

PURPOSE: In vaccine efficacy evaluation, visualization of pathogens in whole organism at each time point would be able to reduce the consuming animals and provide the in vivo information within consistent background with identical organism. MATERIALS AND METHODS: Using IVIS spectrum whole live-animal imaging system, fluorescent intensity was optimized and visualized proportionately by concentrating Escherichia coli MC1061 strain which expresses GFP (E. coli-GFP) in BALB/C mice after injection. RESULTS: Local distribution of disseminated E. coli-GFP was traced in each organ by fluorescence. Detached organ showed more obvious fluorescent signal, and intestine showed strongest fluorescent signal. CONCLUSION: This in vivo imaging method using GFP-tagged pathogen strain suggest quantified infected pathogens by fluorescence intensity in whole animals can provide the information about the localization and distribution after infection.

Park PG; Cho MH; Rhie GE; Jeong H; Youn H; Hong KJ

2012-07-01

289

Non-specific Inflammatory Disease Showed Abnormal FDG Uptake in Lower Extremities  

International Nuclear Information System (INIS)

Including malignancy, various disease can show abnormal uptake in bone marrow.1,2) We report a case of non-specific inflammatory FDG uptake in bone marrow mimicking malignancy. A 35-year old woman with fever of unknown origin (FUO) underwent 18F-FDG PET/CT to find out fever focus and unknown malignancy. 18F-FDG was injected and imaged 1hr after injection with Discovery ST (GE, USA). 18F-FDG PET/CT whole body image showed abnormal uptake in lower extremities. MRI and biopsy was also done in the sites of abnormal uptake. PET and MRI suspect malignancy, but biopsy result was non-specific inflammatory process. The patient was improved her clinical condition after antibiotics therapy

2008-01-01

290

Strains of the soil fungus Mortierella show different degradation potentials for the phenylurea herbicide diuron.  

Science.gov (United States)

Microbial pesticide degradation studies have until now mainly focused on bacteria, although fungi have also been shown to degrade pesticides. In this study we clarify the background for the ability of the common soil fungus Mortierella to degrade the phenylurea herbicide diuron. Diuron degradation potentials of five Mortierella strains were compared, and the role of carbon and nitrogen for the degradation process was investigated. Results showed that the ability to degrade diuron varied greatly among the Mortierella strains tested, and the strains able to degrade diuron were closely related. Degradation of diuron was fastest in carbon and nitrogen rich media while suboptimal nutrient levels restricted degradation, making it unlikely that Mortierella utilize diuron as carbon or nitrogen sources. Degradation kinetics showed that diuron degradation was followed by formation of the metabolites 1-(3,4-dichlorophenyl)-3-methylurea, 1-(3,4-dichlorophenyl)urea and an hitherto unknown metabolite suggested to be 1-(3,4-dichlorophenyl)-3-methylideneurea. PMID:23361127

Ellegaard-Jensen, Lea; Aamand, Jens; Kragelund, Birthe B; Johnsen, Anders H; Rosendahl, Søren

2013-01-30

291

A recombinant multimeric immunoglobulin expressed in rice shows assembly-dependent subcellular localization in endosperm cells.  

UK PubMed Central (United Kingdom)

To investigate the role of subunit assembly in the intracellular deposition of multimeric recombinant proteins, we expressed a partially humanized secretory immunoglobulin in rice endosperm cells and determined the subcellular locations of the assembled protein and its individual components. Transgenic rice plants expressing either individual subunits or all the subunits of the antibody were generated by particle bombardment, and protein localization was determined by immunoelectron microscopy. Assembly of the antibody was confirmed by immunoassay and coimmunoprecipitation. Immunolocalization experiments showed no evidence for secretion of the antibody or any of its components to the apoplast. Rather, the nonassembled light chain, heavy chain and secretory component accumulated predominantly within endoplasmic reticulum-derived protein bodies, while the assembled antibody, with antigen-binding function, accumulated specifically in protein storage vacuoles. These results show that the destination of a complex recombinant protein within the plant cell is influenced by its state of assembly.

Nicholson L; Gonzalez-Melendi P; van Dolleweerd C; Tuck H; Perrin Y; Ma JK; Fischer R; Christou P; Stoger E

2005-01-01

292

LINE-1 methylation shows little intra-patient heterogeneity in primary and synchronous metastatic colorectal cancer  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract Background Long interspersed nucleotide element 1 (LINE-1) hypomethylation is suggested to play a role in the progression of colorectal cancer (CRC). To assess intra-patient heterogeneity of LINE-1 methylation in CRC and to understand its biological relevance in invasion and metastasis, we evaluated the LINE-1 methylation at multiple tumor sites. In addition, the influence of stromal cell content on the measurement of LINE-1 methylation in tumor tissue was analyzed. Methods Formalin-fixed paraffin-embedded primary tumor tissue was obtained from 48 CRC patients. Matched adjacent normal colon tissue, lymph node metastases and distant metastases were obtained from 12, 18 and 7 of these patients, respectively. Three different areas were microdissected from each primary tumor and included the tumor center and invasive front. Normal mucosal and stromal cells were also microdissected for comparison with the tumor cells. The microdissected samples were compared in LINE-1 methylation level measured by multicolor MethyLight assay. The assay results were also compared between microdissected and macrodissected tissue samples. Results LINE-1 methylation within primary tumors showed no significant intra-tumoral heterogeneity, with the tumor center and invasive front showing identical methylation levels. Moreover, no difference in LINE-1 methylation was observed between the primary tumor and lymph node and distant metastases from the same patient. Tumor cells showed significantly less LINE-1 methylation compared to adjacent stromal and normal mucosal epithelial cells. Consequently, LINE-1 methylation was significantly lower in microdissected samples compared to macrodissected samples. A trend for less LINE-1 methylation was also observed in more advanced stages of CRC. Conclusions LINE-1 methylation shows little intra-patient tumor heterogeneity, indicating the suitability of its use for molecular diagnosis in CRC. The methylation is relatively stable during CRC progression, leading us to propose a new concept for the association between LINE-1 methylation and disease stage.

Matsunoki Aika; Kawakami Kazuyuki; Kotake Masanori; Kaneko Mami; Kitamura Hirotaka; Ooi Akishi; Watanabe Go; Minamoto Toshinari

2012-01-01

293

Mitochondrial genome sequencing helps show the evolutionary mechanism of mitochondrial genome formation in Brassica  

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Full Text Available Abstract Background Angiosperm mitochondrial genomes are more complex than those of other organisms. Analyses of the mitochondrial genome sequences of at least 11 angiosperm species have showed several common properties; these cannot easily explain, however, how the diverse mitotypes evolved within each genus or species. We analyzed the evolutionary relationships of Brassica mitotypes by sequencing. Results We sequenced the mitotypes of cam (Brassica rapa), ole (B. oleracea), jun (B. juncea), and car (B. carinata) and analyzed them together with two previously sequenced mitotypes of B. napus (pol and nap). The sizes of whole single circular genomes of cam, jun, ole, and car are 219,747 bp, 219,766 bp, 360,271 bp, and 232,241 bp, respectively. The mitochondrial genome of ole is largest as a resulting of the duplication of a 141.8 kb segment. The jun mitotype is the result of an inherited cam mitotype, and pol is also derived from the cam mitotype with evolutionary modifications. Genes with known functions are conserved in all mitotypes, but clear variation in open reading frames (ORFs) with unknown functions among the six mitotypes was observed. Sequence relationship analysis showed that there has been genome compaction and inheritance in the course of Brassica mitotype evolution. Conclusions We have sequenced four Brassica mitotypes, compared six Brassica mitotypes and suggested a mechanism for mitochondrial genome formation in Brassica, including evolutionary events such as inheritance, duplication, rearrangement, genome compaction, and mutation.

Chang Shengxin; Yang Tiantian; Du Tongqing; Huang Yongjuan; Chen Jianmei; Yan Jiyong; He Jianbo; Guan Rongzhan

2011-01-01

294

Mitochondrial genome sequencing helps show the evolutionary mechanism of mitochondrial genome formation in Brassica.  

UK PubMed Central (United Kingdom)

BACKGROUND: Angiosperm mitochondrial genomes are more complex than those of other organisms. Analyses of the mitochondrial genome sequences of at least 11 angiosperm species have showed several common properties; these cannot easily explain, however, how the diverse mitotypes evolved within each genus or species. We analyzed the evolutionary relationships of Brassica mitotypes by sequencing. RESULTS: We sequenced the mitotypes of cam (Brassica rapa), ole (B. oleracea), jun (B. juncea), and car (B. carinata) and analyzed them together with two previously sequenced mitotypes of B. napus (pol and nap). The sizes of whole single circular genomes of cam, jun, ole, and car are 219,747 bp, 219,766 bp, 360,271 bp, and 232,241 bp, respectively. The mitochondrial genome of ole is largest as a resulting of the duplication of a 141.8 kb segment. The jun mitotype is the result of an inherited cam mitotype, and pol is also derived from the cam mitotype with evolutionary modifications. Genes with known functions are conserved in all mitotypes, but clear variation in open reading frames (ORFs) with unknown functions among the six mitotypes was observed. Sequence relationship analysis showed that there has been genome compaction and inheritance in the course of Brassica mitotype evolution. CONCLUSIONS: We have sequenced four Brassica mitotypes, compared six Brassica mitotypes and suggested a mechanism for mitochondrial genome formation in Brassica, including evolutionary events such as inheritance, duplication, rearrangement, genome compaction, and mutation.

Chang S; Yang T; Du T; Huang Y; Chen J; Yan J; He J; Guan R

2011-01-01

295

An expanded phylogeny of social amoebas (Dictyostelia) shows increasing diversity and new morphological patterns  

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Full Text Available Abstract Background Social Amoebae or Dictyostelia are eukaryotic microbes with a unique life cycle consisting of both uni- and multicellular stages. They have long fascinated molecular, developmental and evolutionary biologists, and Dictyostelium discoideum is now one of the most widely studied eukaryotic microbial models. The first molecular phylogeny of Dictyostelia included most of the species known at the time and suggested an extremely deep taxon with a molecular depth roughly equivalent to Metazoa. The group was also shown to consist of four major clades, none of which correspond to traditional genera. Potential morphological justification was identified for three of the four major groups, on the basis of which tentative names were assigned. Results Over the past four years, the Mycetozoan Global Biodiversity Survey has identified many new isolates that appear to be new species of Dictyostelia, along with numerous isolates of previously described species. We have determined 18S ribosomal RNA gene sequences for all of these new isolates. Phylogenetic analyses of these data show at least 50 new species, and these arise from throughout the dictyostelid tree breaking up many previously isolated long branches. The resulting tree now shows eight well-supported major groups instead of the original four. The new species also expand the known morphological diversity of the previously established four major groups, violating nearly all previously suggested deep morphological patterns. Conclusions A greatly expanded phylogeny of Dictyostelia now shows even greater morphological plasticity at deep taxonomic levels. In fact, there now seem to be no obvious deep evolutionary trends across the group. However at a finer level, patterns in morphological character evolution are beginning to emerge. These results also suggest that there is a far greater diversity of Dictyostelia yet to be discovered, including novel morphologies.

Romeralo Maria; Cavender James C; Landolt John C; Stephenson Steven L; Baldauf Sandra L

2011-01-01

296

Peritoneal ectopic lesions from women with endometriosis show abnormalities in progesterone-dependent glycan expression.  

Science.gov (United States)

Examination of 12 paired peritoneal ectopic and eutopic endometria for histochemical binding of Dolichos biflorus agglutinin, normally found in the mid-late secretory part of the cycle, showed a failure of lectin binding in 9 of 11 secretory-phase lesions although the eutopic specimens generally stained normally. This failure of glycan expression in the secretory phase may result from various anomalies, including an inability to respond to progesterone, possibly due to a lack of, or to nonfunctional, progesterone receptors, suggesting that an ectopic environment may produce changes in tissue cell biology and hormonal responsiveness compared with that of eutopic endometrium. PMID:19131060

Jones, Carolyn J P; Nardo, Luciano G; Litta, Pietro; Fazleabas, Asgerally T

2009-01-07

297

Peritoneal ectopic lesions from women with endometriosis show abnormalities in progesterone-dependent glycan expression.  

UK PubMed Central (United Kingdom)

Examination of 12 paired peritoneal ectopic and eutopic endometria for histochemical binding of Dolichos biflorus agglutinin, normally found in the mid-late secretory part of the cycle, showed a failure of lectin binding in 9 of 11 secretory-phase lesions although the eutopic specimens generally stained normally. This failure of glycan expression in the secretory phase may result from various anomalies, including an inability to respond to progesterone, possibly due to a lack of, or to nonfunctional, progesterone receptors, suggesting that an ectopic environment may produce changes in tissue cell biology and hormonal responsiveness compared with that of eutopic endometrium.

Jones CJ; Nardo LG; Litta P; Fazleabas AT

2009-04-01

298

Three results on Frobenius categories  

CERN Document Server

This paper consists of three results on Frobenius categories: (1) we give sufficient conditions on when a factor category of a Frobenius category is still a Frobenius category; (2) we show that any Frobenius category is equivalent to an extension-closed exact subcategory of the Frobenius category formed by Cohen-Macaulay modules over some additive category; this is an analogue of Gabriel-Quillen's embedding theorem for Frobenius categories; (3) we show that under certain conditions an exact category with enough projective and enough injective objects allows a natural new exact structure, with which the given category becomes Frobenius. Several applications of the results are discussed.

Chen, Xiao-Wu

2010-01-01

299

Why does a Large Shadow Economy not show up in Administrative Inspections?  

Directory of Open Access Journals (Sweden)

Full Text Available This paper deals with the apparent gap that exists between very high estimates of the size of the shadow economy and the results of various tax and policy authorities’ inspections. The analyses are based on Finnish data, with the benchmark values for the size of the shadow economy taken from a recent parliamentary investigation which arrived at very high values for all types of shadow economy activities. These estimates are compared with the Finnish Tax Administration’s own data on tax audits. The data are also used in assessing the fiscal results from tax inspections and other administrative actions. These values suggest that it is pointless to spend enormous amounts of resources to curtail the shadow economy unless one can show that there are important economies of scale in tax audits and law enforcement. Our estimates do not support the idea of increasing returns in tax audits.

Kari Takala; Matti Viren

2012-01-01

300

Persons with multiple sclerosis show altered joint kinetics during walking after participating in elliptical exercise.  

UK PubMed Central (United Kingdom)

Patients with multiple sclerosis (MS) experience abnormal gait patterns and reduced physical activity. The purpose of this study was to determine if an elliptical exercise intervention for patients with MS would change joint kinetics during gait toward healthy control values. Gait analysis was performed on patients with MS (n = 24) before and after completion of 15 sessions of supervised exercise. Joint torques and powers were calculated, while also using walking velocity as a covariate, to determine the effects of elliptical exercise on lower extremity joint kinetics during gait. Results show that elliptical exercise significantly altered joint torques at the ankle and hip and joint powers at the ankle during stance. The change in joint power at the ankle indicates that, after training, patients with MS employed a walking strategy that is more similar to that of healthy young adults. These results support the use of elliptical exercise as a gait training tool for patients with MS.

Huisinga JM; Schmid KK; Filipi ML; Stergiou N

2012-07-01

 
 
 
 
301

Anatomical and genetic study of an ancient animal tooth showing brachyodont and hypsodont mixed taxonomical characteristics.  

Science.gov (United States)

A non-human dental piece was found in a Roman Empire tomb dated the 3rd century A.C. in Zaragoza (Spain). The morphology of this piece showed mixed brachyodont (carnivores) and hypsodont (herbivores) characteristics. As a result, the taxonomical assignation of the piece was impossible. Therefore, a protocolbased on the DNA sequence of the cytochrome c oxidase subunit 1 mitochondrial region (COI) was applied. For this purpose, a pair of primers able to amplify thisregion in a large variety of animals was designed. The results point to a species of the Genus Bos (Family Bovidae). This assignation was later confirmed by these quencing of a short fragment of the mitochondrial D-loop region. A complete morphological description of the tooth is presented together with the DNA sequence study and comparison protocol. PMID:23740506

Monteagudo, L V; Obón, J A; Whyte, A; Tejedor, M T; Whyte, J; Cisneros, A

2013-01-01

302

Clinical aspects of very-low-birthweight infants showing reopening of ductus arteriosus.  

UK PubMed Central (United Kingdom)

BACKGROUND: Indomethacin is used to treat the hemodynamically significant patent ductus arteriosus in premature infants. Some infants show ductus arteriosus reopening after effective constriction by the drug. The purpose of this study was to examine the clinical characteristics of such infants. METHODS: We studied 57 very-low-birthweight infants with effective constriction of patent ductus arteriosus by the initial course of indomethacin. They were classified into the reopened group if they developed hemodynamically significant patent ductus arteriosus again or into the closed group if they showed complete closure. Clinical characteristics were compared between the two groups. RESULTS: Ductus arteriosus reopening was shown in 15 (26%) of the 57 infants. These 15 infants had successful clinical ductal closure after a subsequent course of indomethacin or oral mefenamic acid treatment or surgical ligation without any severe complications. Infants in the reopened group showed significantly higher rates of developing chronic lung disease at 36 weeks of gestation than those in the closed group (53% vs 18%; P= 0.009). Furthermore, multivariate logistic regression analysis revealed ductus arteriosus reopening was the only independent risk factor for developing chronic lung disease at 36 postconceptional weeks in this population (adjusted odds ratio, 6.1; 95% confidence interval, 1.4-31.2; P= 0.02). CONCLUSIONS: Incomplete closure of the ductus arteriosus is associated with recurrence of a clinically significant patent ductus arteriosus and reopening of the ductus after initial closure with indomethacin is associated with chronic lung disease.

Uchiyama A; Nagasawa H; Yamamoto Y; Tatebayashi K; Suzuki H; Yamada K; Arai M; Kohno Y

2011-06-01

303

Carbon nanotube fiber microelectrodes show a higher resistance to dopamine fouling.  

UK PubMed Central (United Kingdom)

We have compared the properties and resistance to DA fouling of a carbon nanotube fiber (CNTF) microelectrode to a traditional carbon fiber (CF) microelectrode. These two materials show comparable electrochemical activities for outer-sphere and inner-sphere redox reactions. Although the CNTF might have a higher intrinsic RC constant, thus limiting its high-frequency behavior, the CNTF shows a significantly higher durability than the CF in terms of electrode stability. During constant oxidation of 100 ?M DA, the signal measured by the CNTF microelectrode shows a 2-h window over which no decrease in current is observed. Under the same conditions, the current obtained at the CF microelectrode decreases by almost 50%. A model of the fouling process, assuming the formation of growing patches of insulator on the surface, has been compared to the data. This model is found to be in good agreement with our results and indicates a growth rate of the patches in the 0.1-2 nm s(-1) range.

Harreither W; Trouillon R; Poulin P; Neri W; Ewing AG; Safina G

2013-08-01

304

Live Reporting in a News / Current Affairs TV Show as a Factor of (Non) Credibility  

Directory of Open Access Journals (Sweden)

Full Text Available Only a perfunctory glance at the content of current aff airs/news programs makes it clear that in just a few years time, live reporting on Croatian TV news shows has increased dramatically. Technologicaladvancements, the equipping of TV stations with mobile satellite vans, and the pressure of competition have all resulted in increased instances of live reporting. When investigating news values, pictureand sound, as well as the possibility of immediate, timely reporting represent the key characteristics of TV journalism. In this context, live reports, as part of a news segment, should add to the authenticity and credibility of the program. Currently, however, TV broadcasting houses attempt to best one another in the number of live broadcasts as a means to purport a higher quality of their program. The direct address to the camera turns a reporter from an anonymous bearer of information into the “main star”. The figures accumulated on the extent of this form used in a news show do not determine the professional level of the editorial policy. Live reporting cannot be regarded as news value if other news values are neglected in the process. Recent research shows that live reports, in most cases, have been stripped of the initial notion of reporting on important and recent events. As such, they are becoming less of a justifi ed element in the creation of news.

Tena Perišin

2010-01-01

305

Pterostilbene and tamoxifen show an additive effect against breast cancer in vitro.  

UK PubMed Central (United Kingdom)

BACKGROUND: Tamoxifen is widely used for the treatment of breast cancer. Pterostilbene, a bioavailable stilbenoid found in blueberries, has been found to inhibit breast cancer growth in vitro. It was hypothesized that combining pterostilbene with tamoxifen would produce additive effects on estrogen receptor-positive breast cancer cells. METHODS: Two estrogen receptor-positive breast cancer cell lines, MCF7 and ZR-751, were pretreated with graduated doses of pterostilbene for 24 hours, followed by 5 ?mol/L tamoxifen. MTT proliferation assays and Cell Death Detection ELISA(PLUS) tests evaluated cell viability and apoptosis. RESULTS: MCF7 cells showed inhibition (10 and 20 ?mol/L, P < .001; 30 ?mol/L, P < .05) at all time points when combined with tamoxifen. ZR-751 cells showed additive reductions in cell viability (P < .001). Cell Death Detection ELISA(PLUS) indicated increased apoptosis (P < .01). CONCLUSIONS: Pterostilbene shows an additive inhibitory effect on breast cancer cells when combined with tamoxifen, most likely from augmented cancer cell apoptosis.

Mannal P; McDonald D; McFadden D

2010-11-01

306

Cryopreservation of human failed maturation oocytes shows that vitrification gives superior outcomes to slow cooling.  

UK PubMed Central (United Kingdom)

This study investigated whether failed maturation oocytes could be used to evaluate different cryopreservation procedures. A total of 289 failed maturation oocytes (GV and MI stages), obtained from 169 patients undergoing IVF treatment (mean age 33.84±5.0) were divided into two different slow-cooling groups (1.5 mol/l 1,2-propanediol+0.2 mol/l sucrose in either NaCl (group A) or choline chloride (ChCl) (group B) based cryopreservation solutions) and one vitrification group (15% ethylene glycol+15% dimethyl sulphoxide). Survival rate, in vitro maturation (IVM) rate, fertilization and developmental rate of cryopreserved oocytes were assessed. Regardless of the stage at which cryopreservation was performed (GV+MI), the slow cooling with ChCl based medium always gave significantly lower survival rate than the slow cooling in NaCl based medium (p=0.01) and vitrification (p<0.001). An extended study also showed statistically reduced survival rate between slow-cooling NaCl based medium and vitrification (p<0.05). Global results of in vitro maturation and fertilization showed worse results between both slow-cooling NaCl and ChCl based media versus vitrification. In conclusion, for oocytes that had failed to mature, vitrification gave better survival, maturation, fertilization and also cleavage rates than the slow-cooling protocols. Four cells embryos were obtained only from vitrified in vitro matured MI oocytes.

Fasano G; Vannin AS; Biramane J; Delbaere A; Englert Y

2010-12-01

307

Cryopreservation of human failed maturation oocytes shows that vitrification gives superior outcomes to slow cooling.  

Science.gov (United States)

This study investigated whether failed maturation oocytes could be used to evaluate different cryopreservation procedures. A total of 289 failed maturation oocytes (GV and MI stages), obtained from 169 patients undergoing IVF treatment (mean age 33.84±5.0) were divided into two different slow-cooling groups (1.5 mol/l 1,2-propanediol+0.2 mol/l sucrose in either NaCl (group A) or choline chloride (ChCl) (group B) based cryopreservation solutions) and one vitrification group (15% ethylene glycol+15% dimethyl sulphoxide). Survival rate, in vitro maturation (IVM) rate, fertilization and developmental rate of cryopreserved oocytes were assessed. Regardless of the stage at which cryopreservation was performed (GV+MI), the slow cooling with ChCl based medium always gave significantly lower survival rate than the slow cooling in NaCl based medium (p=0.01) and vitrification (p<0.001). An extended study also showed statistically reduced survival rate between slow-cooling NaCl based medium and vitrification (p<0.05). Global results of in vitro maturation and fertilization showed worse results between both slow-cooling NaCl and ChCl based media versus vitrification. In conclusion, for oocytes that had failed to mature, vitrification gave better survival, maturation, fertilization and also cleavage rates than the slow-cooling protocols. Four cells embryos were obtained only from vitrified in vitro matured MI oocytes. PMID:20727873

Fasano, G; Vannin, A S; Biramane, J; Delbaere, A; Englert, Y

2010-08-19

308

Elderly subjects with type 2 diabetes show altered tissue electrical properties.  

UK PubMed Central (United Kingdom)

OBJECTIVE: The aim of the present research was to show the characteristics of body composition in a sample of elderly subjects with type 2 diabetes compared with healthy controls matched by age and body mass index (BMI) by bioelectrical impedance vector analysis. METHODS: The sample consisted of 144 free-living patients (84 women and 60 men) with type 2 diabetes 60 to 84 y old and 209 age-matched controls (116 women and 93 men). Anthropometric measurements (weight; height; upper arm, hip, waist, and calf circumferences; biceps; triceps; and subscapular and suprailiac skinfolds) were taken. Blood samples for the assessment of plasma glucose and glycated hemoglobin were collected. The BMI, upper arm muscular area, and waist-to-hip ratio were calculated. Bioelectrical impedance vector analysis was applied. The analysis was performed in the entire diabetic sample and the healthy BMI-matched groups. RESULTS: Compared with healthy subjects, patients had greater weight (P < 0.01 in women), higher BMI (P < 0.01 in women), smaller muscular area (P < 0.01 in men), and thicker skinfolds (P < 0.01 in women and men). Female and male patients showed larger phase angles (P < 0.01). Moreover, female patients showed a shorter vector length and lower resistance (P < 0.01) and male patients showed a higher reactance (P < 0.01). The BMI-matched analysis confirmed that patients were characterized by larger phase angles. CONCLUSIONS: Older patients with type 2 diabetes were characterized by peculiar anthropometric and bioelectrical patterns, which can be related to their smaller appendicular muscular area and lower extracellular/intracellular water ratio.

Buffa R; Saragat B; Succa V; Ruggiu R; Carboni L; Putzu PF; Marini E

2013-01-01

309

The 2009 pandemic (H1N1) viruses isolated from pigs show enhanced pathogenicity in mice.  

UK PubMed Central (United Kingdom)

Since the emergence of the 2009 pandemic (H1N1) virus (2009/H1N1) in April 2009, cases of transmission from humans to pigs have been reported frequently. In our previous studies, four 2009/H1N1 variants were isolated from pigs. To better understand the phenotypic differences of the pig isolates compared with the human isolate, in this study mice were inoculated intranasally with different 2009/H1N1 viruses, and monitored for morbidity, mortality, and viral replication, cytokine production and pathological changes in the lungs. The results show that all isolates show effective replication in lungs, but varying in their ability to cause morbidity. In particular, the strains of A/swine/Nanchang/3/2010 (H1N1) and A/swine/Nanchang/F9/2010 (H1N1) show the greatest virulence with a persisting replication in lungs and high lethality for mice, compared with the human isolate A/Liaoning /14/2009 (H1N1), which shows low virulence in mice. Furthermore, the lethal strains could induce more severe lung pathological changes and higher production of cytokines than that of other strains at an early stage. Amino acid sequence analysis illustrates prominent differences in viral surface glycoproteins and polymerase subunits between pig isolates and human strains that might correlate with their phenotypic differences. These studies demonstrate that the 2009/H1N1 pig isolates exhibit heterogeneous infectivity and pathogencity in mice, and some strains possess an enhanced pathogenicity compared with the human isolate.

Li Y; Zou W; Jia G; Ke J; Zhu J; Lin X; Zhou H; Jin M

2013-01-01

310

Identification of Tritrichomonas foetus and Giardia spp. infection in pedigree show cats in New Zealand.  

UK PubMed Central (United Kingdom)

AIMS: To establish the presence of Tritrichomonas foetus, to investigate the prevalence of co-infection with Giardia spp., and determine risk factors for T. foetus infection in pedigree show cats in New Zealand. METHODS: Freshly voided faecal samples were collected from cats attending two regional pedigree cat shows in the North Island during 2006. The samples were subjected to ZnSO4 floatation; ELISA for Giardia spp.; culture for T. foetus; and DNA isolation, amplification, and sequencing. Owners were asked to complete a questionnaire concerning aspects of the cats' environment, previous medical history, and diet. RESULTS: Faecal samples were collected from 22 cats from 12 separate catteries. Giardia spp. were identified using ELISA or faecal floatation in seven samples, and Sarcocystis spp. were identified in four samples. Tritrichomonas foetus was cultured from three samples, but 18 samples were positive on PCR. Two were randomly selected for representative sequencing. Basic local alignment search tool (BLAST) analysis results indicated 100% homology to T. foetus internal transcribed spacer 1. Poor faecal quality was apparent in only 8/22 samples, all of which were positive for T. foetus, and five of the eight were from cats with a previous history of chronic intermittent diarrhoea. Five samples were positive for both T. foetus and Giardia spp. Numbers of participants were too low to assess risk factors or significant associations. CONCLUSIONS: This is the first report of the presence of T. foetus-infected cats in New Zealand, and the large proportion of PCR-positive samples was much greater than previous surveys of pedigree cats in other countries. CLINICAL RELEVANCE: Tritrichomonas foetus infection is recognised as an important cause of chronic large-bowel diarrhoea in cats, and may be highly prevalent in pedigree show cats in New Zealand, with the potential for co-infection with Giardia spp. Diagnosis is simple, and should involve PCR for the greatest sensitivity.

Kingsbury DD; Marks SL; Cave NJ; Grahn RA

2010-02-01

311

Diabetes patients show different time-course of myocardial perfusion improvement after coronary artery bypass grafting  

Energy Technology Data Exchange (ETDEWEB)

Diabetes mellitus is an independent risk factor of cardiovascular disease. Diabetes is known to cause microangiopathy. The microangiopathy is hardly detectable on the coronary angiography. Myocardial perfusion imaging shows the resultant perfusion status which reflects the microangiopathy. For patients who underwent revascularization, the microangiopathy could affect the myocardial perfusion improvement. Diabetes patients probably experience the different myocardial perfusion improvement as compared to the non-diabetes patients although they have similar angiographic findings. The aim of this study is to find out whether there is a time-course difference of perfusion improvement between the diabetes and non diabetes patients who showed patent angiographic findings after coronary artery grafting surgery (CABG). A total of 129 patients who underwent coronary artery bypass grafting surgery were enrolled in this study. Myocardial SPECTs performed at previous, short-term (3 month), and mid-term (1 year) to CABG. One-year follow up angiography was done 411{+-}121 days after surgery. Graft patency was determined according to the FitzGibbon et al. Segments were assigned to vascular territories using a 20 segment model. The segments of excellent patency were included in this study. Time course differences of concerned segments were analyzed using RMANOVA. The number of segments enrolled was 764 of diabetes and 1083 of non-diabetes. At short-term follow up, reversibility score was 2.8{+-}8.1% in diabetes and 0.3{+-}7.5% in non-diabetes. At long-term follow up, reversibility score was 1.8{+-}8.0% in diabetes and 0.1{+-}7.3% in non-diabetes. The time-course of reversibility score was significantly different between the diabetes and non diabetes (p<0.001) Diabetic segments showed high residual reversibility score than non-diabetic segments after CABG although the angiographic finding was patent in both groups. This result is maybe attributable to microangiopathy induced by diabetes.

Lee, J. J.; Seok, J. W.; Eo, J. S. [Seoul National University Hospital, Seoul (Korea, Republic of)] (and others)

2005-07-01

312

Characteristics of subsolid pulmonary nodules showing growth during follow-up with CT scanning.  

UK PubMed Central (United Kingdom)

OBJECTIVE: The positive results of a screening CT scan trial are likely to lead to an increase in the use of CT scanning, and, consequently, an increase in the detection of subsolid nodules. Noninvasive methods including follow-up with CT scanning, to determine which nodules require invasive diagnosis and surgical treatment, should be defined promptly. METHODS: Between 2000 and 2008, from our database of . 60,000 examinations with CT scanning, we identified 174 subsolid nodules, which showed a ground-glass opacity area . 20% of the nodule and measured 2 cm in diameter, in 171 patients. We investigated the clinical characteristics and CT images of the subsolid nodules in relation to changes identified during the follow-up period. RESULTS: The nodule sizes ranged from 4 mm to 20 mm at the fi rst presentation. Nonsolid nodules numbered 98. During the follow-up period, 18 nodules showed resolution or shrinkage, and 41 showed growth of 2 mm or more in diameter. The time to 2-mm nodule-growth curves calculated by Kaplan-Meier methods indicated that the 2-year and 5-year cumulative percentages of growing nodules were 13% and 23% in patients with nonsolid nodules and 38% and 55% in patients with part-solid nodules, respectively. Multivariate analysis disclosed that a large nodule size ( . 10 mm) and history of lung cancer were significant predictive factors of growth in nonsolid nodules. CONCLUSIONS: An effective schedule for follow-up with CT scanning for subsolid nodules should be developed according to the type of subsolid nodule, initial nodule size, and history of lung cancer.

Matsuguma H; Mori K; Nakahara R; Suzuki H; Kasai T; Kamiyama Y; Igarashi S; Kodama T; Yokoi K

2013-02-01

313

A physical map of Brassica oleracea shows complexity of chromosomal changes following recursive paleopolyploidizations  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract Background Evolution of the Brassica species has been recursively affected by polyploidy events, and comparison to their relative, Arabidopsis thaliana, provides means to explore their genomic complexity. Results A genome-wide physical map of a rapid-cycling strain of B. oleracea was constructed by integrating high-information-content fingerprinting (HICF) of Bacterial Artificial Chromosome (BAC) clones with hybridization to sequence-tagged probes. Using 2907 contigs of two or more BACs, we performed several lines of comparative genomic analysis. Interspecific DNA synteny is much better preserved in euchromatin than heterochromatin, showing the qualitative difference in evolution of these respective genomic domains. About 67% of contigs can be aligned to the Arabidopsis genome, with 96.5% corresponding to euchromatic regions, and 3.5% (shown to contain repetitive sequences) to pericentromeric regions. Overgo probe hybridization data showed that contigs aligned to Arabidopsis euchromatin contain ~80% of low-copy-number genes, while genes with high copy number are much more frequently associated with pericentromeric regions. We identified 39 interchromosomal breakpoints during the diversification of B. oleracea and Arabidopsis thaliana, a relatively high level of genomic change since their divergence. Comparison of the B. oleracea physical map with Arabidopsis and other available eudicot genomes showed appreciable 'shadowing' produced by more ancient polyploidies, resulting in a web of relatedness among contigs which increased genomic complexity. Conclusions A high-resolution genetically-anchored physical map sheds light on Brassica genome organization and advances positional cloning of specific genes, and may help to validate genome sequence assembly and alignment to chromosomes. All the physical mapping data is freely shared at a WebFPC site (http://lulu.pgml.uga.edu/fpc/WebAGCoL/brassica/WebFPC/; Temporarily password-protected: account: pgml; password: 123qwe123.

Wang Xiyin; Torres Manuel J; Pierce Gary; Lemke Cornelia; Nelson Lisa K; Yuksel Bayram; Bowers John E; Marler Barry; Xiao Yongli; Lin Lifeng; Epps Ethan; Sarazen Heidi; Rogers Carl; Karunakaran Santhosh; Ingles Jennifer; Giattina Emily; Mun Jeong-Hwan; Seol Young-Joo; Park Beom-Seok; Amasino Richard M; Quiros Carlos F; Osborn Thomas C; Pires J; Town Christopher; Paterson Andrew H

2011-01-01

314

Resultative Predicates in Japanese  

Directory of Open Access Journals (Sweden)

Full Text Available Washio (1997; 1999) observes that resultative predicates are divided into two different groups, strong and weak resultatives, depending on ‘patienthood’ of the object. This typology of resultatives seems to capture a point of crosslinguistic variation in resultatives; Japanese has weak but not strong resultatives, while English has both. Washio also observes that there is another group of examples that bears a superficial resemblance to resultatives but constitutes a different phenomenon, hence spurious resultatives. The difference between weak and strong resultatives is made in terms of the ‘affectedness’ of the verb. Thus the typology of resultatives proposed by Washio is semantically grounded. In this paper, I propose: (i) a fine-grained distinction for Washio’s weak resultatives: (ii) a syntactic analysis of the different resultative types. On the basis of syntactic evidence, I argue that there are two types of weak resultatives, an adjunct of VP and a complement of VP within the vP projection. I also argue that spurious resultatives are structurally higher than weak resultatives in Japanese.

Kaori Takamine

2007-01-01

315

Grain size and temperature influence on the toughness of a CuAlBe shape memory alloy  

International Nuclear Information System (INIS)

Research highlights: ? This work evaluated the capacity of a CuAlBe alloy to absorb energy until rupture. ? The V-notch Charpy test was adopted at -150, -100, -50, 0, 50, 100 and 150 deg. C. ? Charpy tests were complemented by DSC, DSC with optical microscope and by SEM. ? First work to analyze the toughness of a CuAlBe alloy based on the Charpy test. ? The results are of relevant value to enhance the understanding of the CuAlBe alloy. - Abstract: This work is a study of the influence of grain size and temperature on the toughness of CuAlBe shape memory alloys with (CuAlBeNbNi) and without NbNi (CuAlBe) grain refiner elements. The toughness analysis was based on the V-notch Charpy impact test under temperatures of -150, -100, -50, 0, 50, 100 and 150 deg. C. A statistical analysis of the results led to the conclusion that the toughness of both alloys was influenced by temperature and grain size. The CuAlBeNbNi alloy absorbed higher impact energy than the CuAlBe alloy showing that the refining elements improved the toughness of the alloy. To confirm and complement these findings, the fracture surfaces were evaluated by stereomicroscopy. Smooth homogeneous surfaces and rough heterogonous surfaces were detected for the CuAlBeNbNi and CuAlBe alloys, respectively. Predominately brittle zones were confirmed by scanning electron microscopy in both alloys. Furthermore, to determine the phase transformation temperatures and the associated microstructures, the alloys were assessed by conventional differential scanning calorimetry (DSC) and DSC with optical microscopy.

2010-11-25

316

El SHOW DE JORGE BARÓN como paradigma de neopopulismo cultural en la televisión Colombiana JORGE BARON'S show as paradigm of cultural neo-populism in the colombian television  

Directory of Open Access Journals (Sweden)

Full Text Available Este artículo parte de la investigación de campo sobre El Show de las Estrellas, el programa musical más antiguo y popular de la televisión colombiana. El análisis de caso es un pretexto para replantear la discusión sobre políticas culturales en el contexto -aparentemente paradójico- de violencia estructural, privatización y auge del populismo de derecha que caracteriza la política en Colombia en los últimos años.This article comes from the investigation field of the Stars Show (El Show de las Estrellas), the oldest and most popular musical TV show in Colombian television. The case analysis is an excuse to reframe the discussion on cultural policies in the context, apparently paradoxical, of structural violence, privatization and peak of the right populism that characterizes the Colombian politics in the last years.

Isabel Noemí Rodríguez; Adolfo Chaparro Amaya

2010-01-01

317

El SHOW DE JORGE BARÓN como paradigma de neopopulismo cultural en la televisión Colombiana/ JORGE BARON'S show as paradigm of cultural neo-populism in the colombian television  

Scientific Electronic Library Online (English)

Full Text Available Abstract in spanish Este artículo parte de la investigación de campo sobre El Show de las Estrellas, el programa musical más antiguo y popular de la televisión colombiana. El análisis de caso es un pretexto para replantear la discusión sobre políticas culturales en el contexto -aparentemente paradójico- de violencia estructural, privatización y auge del populismo de derecha que caracteriza la política en Colombia en los últimos años. Abstract in english This article comes from the investigation field of the Stars Show (El Show de las Estrellas), the oldest and most popular musical TV show in Colombian television. The case analysis is an excuse to reframe the discussion on cultural policies in the context, apparently paradoxical, of structural violence, privatization and peak of the right populism that characterizes the Colombian politics in the last years.

Rodríguez, Isabel Noemí; Chaparro Amaya, Adolfo

2010-12-01

318

[Thyroid carcinoma showing thymus-like differentiation: a clinicopathologic study of 8 cases].  

UK PubMed Central (United Kingdom)

OBJECTIVE: To study the clinicopathologic features, immunophenotypes and differential diagnosis of thyroid carcinoma showing thymus-like differentiation (CASTLE). METHODS: The clinical and pathologic features of 8 cases of CASTLE were reviewed. Immunohistochemical study was performed using a panel of antibodies. In-situ hybridization for Epstein-Barr virus-encoded RNA (EBER) was also carried out. RESULTS: There were altogether 4 males and 4 females. The age of the patients ranged from 25 to 57 years (mean = 48.8 years). All of them presented with painless mass at the anterior neck. Two patients also complained of hoarseness of voice. On CT scan, the tumor had a low density with contrast enhancement. Seven cases were located in the mid to lower pole and the remaining one in the upper pole of thyroid gland. Four cases were relatively circumscribed. The other 4 cases showed evidence of extrathyroidal invasion. Grossly, the tumor had a nodular or lobulated appearance and was gray-white in color, with a mean diameter of 4.3 cm. Microscopically, the tumor was infiltrative and consisted of islands, nests or lobules of epithelial cells separated by thick fibrous septa. The fibrous stroma showed various degree of lymphoplasmacytic infiltration, resulting in a prominent lymphoepithelioma-like pattern in 3 cases. Two cases showed squamoid differentiation, mimicking thymic Hassall corpuscles. Immunohistochemically, the tumor was consistently positive for cytokeratins, CD5, bcl-2, p63 and CD117. CEA was variably expressed. The staining for thyroglobin and TTF1 was negative. There was no labeling for EBER in all the cases. Two patients experienced local recurrence at 22 months and 12 years after surgery, respectively. They were treated with re-resection. All patients remained well on follow up. The duration of follow up ranged from 4 to 55 months. CONCLUSIONS: CASTLE is a low-grade thyroid carcinoma with the morphologic features and immunophenotypes overlapping with those of thymic carcinoma. Awareness of this rare entity is important to both the pathologists and clinicians.

Liu X; Hadeti B; Zhang W; Wang J

2011-02-01

319

76 FR 29647 - Safety Zone; Big Rock Blue Marlin Air Show; Bogue Sound, Morehead City, NC  

Science.gov (United States)

...1625-AA00 Safety Zone; Big Rock Blue Marlin Air Show; Bogue Sound, Morehead...Safety Zone for the ``Big Rock Blue Marlin Air Show,'' an aerial demonstration...entitled Safety Zone; Big Rock Blue Marlin Air Show; Bogue Sound,...

2011-05-23

320

Development of a combined CloudSat-CALIPSO cloud mask to show global cloud distribution  

Science.gov (United States)

We developed a cloud mask scheme that combines measurements from CloudSat and Cloud-Aerosol Lidar and Infrared Pathfinder Satellite Observation (CALIPSO) satellites. First, we developed a cloud mask scheme for CALIPSO using a threshold of the attenuated total backscattering coefficient and a spatial continuity test. We then developed a combined CloudSat-CALIPSO cloud mask. These cloud masks were applied to 3 months of data from September to November 2006, and the vertical distributions of zonal mean cloud fractions and cloud coverage were analyzed. We also examined the standard vertical feature mask (VFM) cloud scheme. The VFM occasionally made false detections because of its horizontal averaging procedure and seemed to misclassify noise or aerosols as clouds. In addition, the VFM appeared to significantly overestimate low-level clouds. Below 2 km, the cloud fraction differed by as much as 25% between the VFM and our combined scheme. We also compared the zonal mean cloud coverage for the topmost layer detected by the sensors using our CALIPSO scheme, the VFM, our combined CloudSat-CALIPSO scheme, and the Aqua Moderate Resolution Imaging Spectroradiometer (MODIS) results. For low-level clouds (>680 hPa), the MODIS result was larger than that of our CloudSat-CALIPSO scheme, and results from the VFM and our CALIPSO scheme differed by as much as 15%. The CALIPSO, CloudSat-CALIPSO, and MODIS results were similar for total cloud coverage, but the VFM result was different. Because of possible misclassification at low levels, the VFM showed the largest cloud coverage in middle and low latitudes.

Hagihara, Yuichiro; Okamoto, Hajime; Yoshida, Ryo

2010-01-01

 
 
 
 
321

Clove (Syzygium aromaticum Linn) extract rich in eugenol and eugenol derivatives shows bone-preserving efficacy.  

UK PubMed Central (United Kingdom)

This study examined the efficacy of hydroalcoholic extract of dried clove buds, which is rich in phenolic compounds namely eugenol and eugenol derivatives (precursors of flavones, isoflavones and flavonoids), on different primary and secondary osteoporotic marker changes in an ovariectomised (OVX) rat model of osteoporosis. Female Wistar rats were randomly divided into three groups: sham-operated control (A), OVX (B) and OVX plus 50% hydroalcoholic extract of dried clove buds for 4 weeks (C). Results indicated that, compared to control, serum alkaline phosphatase (AP; 48.25%, p?Results of bone density, bone mineral content, bone tensile strength and histological analysis also showed similar trend of results, which supported initial observations of this study. It is proposed that hydroalcoholic extract of dried clove buds has bone-preserving efficacy against hypogonadal osteoporosis.

Karmakar S; Choudhury M; Das AS; Maiti A; Majumdar S; Mitra C

2012-01-01

322

Total 2004 results  

International Nuclear Information System (INIS)

This document presents the 2004 results of Total Group: consolidated account, special items, number of shares, market environment, adjustment for amortization of Sanofi-Aventis merger-related intangibles, 4. quarter 2004 results (operating and net incomes, cash flow), upstream (results, production, reserves, recent highlights), downstream (results, refinery throughput, recent highlights), chemicals (results, recent highlights), Total's full year 2004 results (operating and net income, cash flow), 2005 sensitivities, Total SA parent company accounts and proposed dividend, adoption of IFRS accounting, summary and outlook, main operating information by segment for the 4. quarter and full year 2004: upstream (combined liquids and gas production by region, liquids production by region, gas production by region), downstream (refined product sales by region, chemicals), Total financial statements: consolidated statement of income, consolidated balance sheet (assets, liabilities and shareholder's equity), consolidated statements of cash flows, business segments information. (J.S.)

2005-01-01

323

Total 2004 results  

Energy Technology Data Exchange (ETDEWEB)

This document presents the 2004 results of Total Group: consolidated account, special items, number of shares, market environment, adjustment for amortization of Sanofi-Aventis merger-related intangibles, 4. quarter 2004 results (operating and net incomes, cash flow), upstream (results, production, reserves, recent highlights), downstream (results, refinery throughput, recent highlights), chemicals (results, recent highlights), Total's full year 2004 results (operating and net income, cash flow), 2005 sensitivities, Total SA parent company accounts and proposed dividend, adoption of IFRS accounting, summary and outlook, main operating information by segment for the 4. quarter and full year 2004: upstream (combined liquids and gas production by region, liquids production by region, gas production by region), downstream (refined product sales by region, chemicals), Total financial statements: consolidated statement of income, consolidated balance sheet (assets, liabilities and shareholder's equity), consolidated statements of cash flows, business segments information. (J.S.)

NONE

2005-02-01

324

Results from Lattice QCD  

Energy Technology Data Exchange (ETDEWEB)

I present our recent results on the critical end point in the {mu}{sub B}-Tphase diagram of QCD with two flavours of light dynamical quarks and compare them with similar results from other groups. Implications for a possible energy scan at the RHIC are discussed. I also comment briefly on the new results of great relevance to heavy ion collisions from finite temperature lattice QCD simulations on speed of sound, specific heat and on the fate of J/{psi}.

Gavai, Rajiv V [Department of Theoretical Physics, Tata Institute of Fundamental Research, Homi Bhabha Road, Mumbai 400 005 (India)

2006-11-15

325

Results from Lattice QCD  

CERN Multimedia

I present our recent results on the critical end point in the \\mu_B-T phase diagram of QCD with two flavours of light dynamical quarks and compare them with similar results from other groups. Implications for a possible energy scan at the RHIC are discussed. I also comment briefly on the new results of great relevance to heavy ion collisions from finite temperature lattice QCD simulations on speed of sound, specific heat and on the fate of J/\\psi.

Gavai, R V

2005-01-01

326

Mycological study for a management plan of a neotropical show cave (Brazil)  

Directory of Open Access Journals (Sweden)

Full Text Available Caves are stable environments with characteristics favoring the development of microorganisms. The allocthonous input of organic matter and microbes into the warm Neotropical caves may favor the development of filamentous fungi, including pathogenic species. Histoplasma capsulatum is a pathogenic species commonly found in caves and associated with bat and bird guano. Many Brazilian caves have been historically visited due to scenic and religious tourism. The objective of this study was to perform a microbiology study for a management plan of a show cave in Brazil, focusing on the presence and distribution of pathogenic and opportunistic fungi in the cave. Statistic analysis was used to verify the influence of touristic activity on airborne fungi spore load. Fungi were isolated from air and guano in Lapa Nova Cave. Samples were obtained through serial dilution, direct and settle plate techniques. For H. capsulatum, samples were incubated in specific media and conditions. Airborne fungal spore load was compared prior and during visitation and statistically analyzed. A total of 2,575 isolates from the genera Aspergillus, Calcarisporium, Chaetomium, Cladosporium, Curvularia, Emericella, Eurotium, Fusarium, Geotrichum, Gliocladium, Mucor, Purpureocillium, Paecilomyces, Penicillium, Rhizopus and Trichoderma were identified. Histoplasma capsulatum was not isolated from the cave. Eleven opportunistic species were identified. Significant (p<0.05) variations on fungal richness in the air occurred due to cave visitation. Areas of potential microbiologic risks were indicated and management actions suggested. The results suggest a diverse community inhabiting the cave. Possible opportunistic species should be monitored in show caves and microbiota should always be included in the elaboration of cave management plans. This is the first detailed microbiologic study for a management plan of a show cave in the country. It provides relevant information for future management plans.

Erika Linzi Silva Taylor; Maria Aparecida de Resende Stoianoff; Rodrigo Lopes Ferreira

2013-01-01

327

A gluten metabolism study in healthy individuals shows the presence of faecal glutenasic activity.  

UK PubMed Central (United Kingdom)

PURPOSE: To study the gluten metabolism in healthy individuals and its effect over the intestinal microbial activity. METHODS: The faeces of eleven healthy subjects were analysed under 4 diet regimens: their normal gluten diet, a strict gluten-free diet (GFD), a GFD with a supplemental intake of 9 g gluten/day and a GFD with a supplemental intake of 30 g gluten/day. Gluten content, faecal tryptic activity (FTA), short-chain fatty acids (SCFAs) and faecal glutenasic activity (FGA) were analysed in faecal samples. RESULTS: Faecal gluten contents, FTA, SCFAs and FGA varied significantly with different levels of gluten intake in the diet. When high gluten doses (30 g/day) were administered in the diet, SCFA concentrations (70.5 mmoles/kg faeces) were significantly different from those from the GFD period (33.8 mmoles/kg faeces) of the experiment. However, the FTA showed significant differences between the GFD (34 units) and the normal gluten-containing diet (60 units) and also between the GFD and the GFD + 30 g of gluten/day (67 units). When gluten was present in the diet, gluten was detected in the faeces, showing that at least a portion of the gluten ingested is eliminated in the large intestine, providing a substrate for intestinal microbial proteases. We have also shown the presence of faecal glutenasic activity that increased proportionally with the gluten intake in the diet, showing an enzymatic activity of 993 units in DSG, 2,063 units in DSG + 9 g and 6,090 units in DSG + 30 g. CONCLUSIONS: The activity of the intestinal microbiota is modified by gluten intake in the diet. The incorporation of gluten in the diet increases the activity of a gluten proteolytic activity in the faeces.

Caminero A; Nistal E; Arias L; Vivas S; Comino I; Real A; Sousa C; de Morales JM; Ferrero MA; Rodríguez-Aparicio LB; Casqueiro J

2012-04-01

328

Bacteria of the Roseobacter clade show potential for secondary metabolite production.  

UK PubMed Central (United Kingdom)

Members of the Roseobacter clade are abundant and widespread in marine habitats and have very diverse metabolisms. Production of acylated homoserine lactones (AHL) and secondary metabolites, e.g., antibiotics has been described sporadically. This prompted us to screen 22 strains of this group for production of signaling molecules, antagonistic activity against bacteria of different phylogenetic groups, and the presence of genes encoding for nonribosomal peptide synthetases (NRPS) and polyketide synthases (PKS), representing enzymes involved in the synthesis of various pharmaceutically important natural products. The screening approach for NRPS and PKS genes was based on polymerase chain reaction (PCR) with degenerate primers specific for conserved sequence motifs. Additionally, sequences from whole genome sequencing projects of organisms of the Roseobacter clade were considered. Obtained PCR products were cloned, sequenced, and compared with genes of known function. With the PCR approach genes showing similarity to known NRPS and PKS genes were found in seven and five strains, respectively, and three PKS and NRPS sequences from genome sequencing projects were obtained. Three strains exhibited antagonistic activity and also showed production of AHL. Overall production of AHL was found in 10 isolates. Phylogenetic analysis of the 16S rRNA gene sequences of the tested organisms showed that several of the AHL-positive strains clustered together. Three strains were positive for three or four categories tested, and were found to be closely related within the genus Phaeobacter. The presence of a highly similar hybrid PKS/NRPS gene locus of unknown function in sequenced genomes of the Roseobacter clade plus the significant similarity of gene fragments from the strains studied to these genes argues for the functional requirement of the encoded hybrid PKS/NRPS complex. Our screening results therefore suggest that the Roseobacter clade is indeed employing PKS/NRPS biochemistry and should thus be further studied as a potential and largely untapped source of secondary metabolites.

Martens T; Gram L; Grossart HP; Kessler D; Müller R; Simon M; Wenzel SC; Brinkhoff T

2007-07-01

329

Hibiscus vitifolius (Linn.) root extracts shows potent protective action against anti-tubercular drug induced hepatotoxicity.  

UK PubMed Central (United Kingdom)

ETHNOPHARMACOLOGICAL RELEVANCE: The roots of Hibiscus vitifolius Linn. (Malvaceae) is used for the treatment of jaundice in the folklore system of medicine in India. This study is an attempt to evaluate the hepatoprotective activity of the roots of Hibiscus vitifolius against anti-tubercular drug induced hepatotoxicity. MATERIALS AND METHODS: Hepatotoxicity was induced in albino rats of either sex by oral administration of a combination of three anti-tubercular drugs. Petroleum ether, chloroform, methanol and aqueous extracts of roots of Hibiscus vitifolius (400mg/kg/day) were evaluated for their possible hepatoprotective potential. RESULTS: All the extracts were found to be safe up to a dose of 2000mg/kg. Among the four extracts studied, oral administration of methanol extract of Hibiscus vitifolius at 400mg/kg showed significant difference in all the parameters when compared to control. There was a significant (P<0.001) reduction in the levels of serum aspartate amino transaminase, alanine amino transferase, alkaline phosphatase, lactate dehydrogenase, total and direct bilirubin, where as an increase was found in the levels of total cholesterol, total protein and albumin. Liver homogenate studies showed a significant increase in the levels of total protein, phospholipids and glycogen, and a reduction in the levels of total lipids, triglycerides, and cholesterol against control animals. In the tissue anti-oxidant studies, we found a significant increase in the levels of catalase and superoxide dismutase, whereas there was marked reduction in the levels of thiobarbituric acid reactive substances, as compared to control. Histology of liver sections of the animals treated with the extracts showed significant reduction of necrosis and fatty formation when compared with control specimens. CONCLUSION: These findings suggest that the root extracts of Hibiscus vitifolius have potent hepatoprotective activity, thereby justifying its ethnopharmacological claim.

Samuel AJ; Mohan S; Chellappan DK; Kalusalingam A; Ariamuthu S

2012-05-01

330

Results from SAGE  

CERN Multimedia

We report the results of 11 years of solar neutrino observation by the Russian-American Gallium solar neutrino Experiment (SAGE). The overall result of 84 runs during the measurement period January 1990 through March 2001 is 75.6 +5.9/-5.8 (stat.) +3.5/-3.0 (syst.) SNU. This represents only slightly more than half of the predicted standard solar model rate of 129 SNU. The individual results of each run, as well as the results of combined analysis of all runs are presented.

Vermul, V M; Bowles, T J; Cherry, M L; Cleveland, B T; Davis, R; Elliott, S R; Gavrin, V N; Girin, S V; Gorbachev, V V; Ibragimova, T V; Kalikhov, A V; Khairnasov, N G; Knodel, T V; Lande, K; Mirmov, I N; Nico, J S; Shikhin, A A; Teasdale, W A; Veretenkin, E P; Vermul, V M; Wark, D L; Wildenhain, P S; Wilkerson, J F; Yants, V E; Zatsepin, G T

2002-01-01

331

Results from SAGE  

International Nuclear Information System (INIS)

We report the results of 11 years of solar neutrino observation by the Russian-American Gallium solar neutrino Experiment (SAGE). The overall result of 84 runs during the measurement period January 1990 through March 2001 is 75.6 +5.9/-5.8 (stat.) +3.5/-3.0 (syst.) SNU. This represents only slightly more than half of the predicted standard solar model rate of 129 SNU. The individual results of each run, as well as the results of combined analysis of all runs are presented

2002-01-01

332

Results from SAGE  

Energy Technology Data Exchange (ETDEWEB)

We report the results of 11 years of solar neutrino observation by the Russian-American Gallium solar neutrino Experiment (SAGE). The overall result of 84 runs during the measurement period January 1990 through March 2001 is 75.6 +5.9/-5.8 (stat.) +3.5/-3.0 (syst.) SNU. This represents only slightly more than half of the predicted standard solar model rate of 129 SNU. The individual results of each run, as well as the results of combined analysis of all runs are presented.

Vermul, V.M.; Abdurashitov, J.N.; Bowles, T.J.; Cherry, M.L.; Cleveland, B.T.; Davis, R.; Elliott, S.R.; Gavrin, V.N.; Girin, S.V.; Gorbachev, V.V.; Ibragimova, T.V.; Kalikhov, A.V.; Khairnasov, N.G.; Knodel, T.V.; Lande, K.; Mirmov, I.N.; Nico, J.S.; Shikhin, A.A.; Teasdale, W.A.; Veretenkin, E.P.; Wark, D.L.; Wildenhain, P.S.; Wilkerson, J.F.; Yants, V.E.; Zatsepin, G.T

2002-07-01

333

Exploratory behaviour in NO-dependent cyclase mutants of Drosophila shows defects in coincident neuronal signalling  

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Full Text Available Abstract Background Drosophila flies explore the environment very efficiently in order to colonize it. They explore collectively, not individually, so that when a few land on a food spot, they attract the others by signs. This behaviour leads to aggregation of individuals and optimizes the screening of mates and egg-laying on the most favourable food spots. Results Flies perform cycles of exploration/aggregation depending on the resources of the environment. This behavioural ecology constitutes an excellent model for analyzing simultaneous processing of neurosensory information. We reasoned that the decision of flies to land somewhere in order to achieve aggregation is based on simultaneous integration of signals (visual, olfactory, acoustic) during their flight. On the basis of what flies do in nature, we designed laboratory tests to analyze the phenomenon of neuronal coincidence. We screened many mutants of genes involved in neuronal metabolism and the synaptic machinery. Conclusion Mutants of NO-dependent cyclase show a specifically-marked behaviour phenotype, but on the other hand they are associated with moderate biochemical defects. We show that these mutants present errors in integrative and/or coincident processing of signals, which are not reducible to the functions of the peripheral sensory cells.

Tinette Sylvette; Zhang Lixing; Garnier Amélie; Engler Gilbert; Tares Sophie; Robichon Alain

2007-01-01

334

Glycosaminoglycans show a specific periodic interaction with type I collagen fibrils.  

UK PubMed Central (United Kingdom)

Current wisdom on intermolecular interactions in the extracellular matrix assumes that small proteoglycans bind collagen fibrils on highly specific sites via their protein core, while their carbohydrate chains interact with each other in the interfibrillar space. The present study used high-resolution scanning electron microscopy to analyse the interaction of two small leucine-rich proteoglycans and several glycosaminoglycan chains with type I collagen fibrils obtained in vitro in a controlled, cell-free environment. Our results show that most ligands directly influence the collagen fibril size and shape, and their aggregation into thicker bundles. All chondroitin sulphate/dermatan sulphate glycosaminoglycans we tested, except chondroitin 4-sulphate, bound to the fibril surface in a highly specific way and, even in the absence of any protein core, formed regular, periodic interfibrillar links resembling those of the intact proteoglycan. Only intact decorin, however, was able to organize collagen fibrils into fibres compact enough to mimic in vitro the superfibrillar organization of natural tissues. Our data indicate that multiple interaction patterns may exist in vivo, may explain why decorin- or biglycan-knockout organisms show milder effects than can be expected, and may lead to the development of better, simpler engineered biomaterials.

Raspanti M; Viola M; Forlino A; Tenni R; Gruppi C; Tira ME

2008-10-01

335

Glycosaminoglycans show a specific periodic interaction with type I collagen fibrils.  

Science.gov (United States)

Current wisdom on intermolecular interactions in the extracellular matrix assumes that small proteoglycans bind collagen fibrils on highly specific sites via their protein core, while their carbohydrate chains interact with each other in the interfibrillar space. The present study used high-resolution scanning electron microscopy to analyse the interaction of two small leucine-rich proteoglycans and several glycosaminoglycan chains with type I collagen fibrils obtained in vitro in a controlled, cell-free environment. Our results show that most ligands directly influence the collagen fibril size and shape, and their aggregation into thicker bundles. All chondroitin sulphate/dermatan sulphate glycosaminoglycans we tested, except chondroitin 4-sulphate, bound to the fibril surface in a highly specific way and, even in the absence of any protein core, formed regular, periodic interfibrillar links resembling those of the intact proteoglycan. Only intact decorin, however, was able to organize collagen fibrils into fibres compact enough to mimic in vitro the superfibrillar organization of natural tissues. Our data indicate that multiple interaction patterns may exist in vivo, may explain why decorin- or biglycan-knockout organisms show milder effects than can be expected, and may lead to the development of better, simpler engineered biomaterials. PMID:18664384

Raspanti, Mario; Viola, Manuela; Forlino, Antonella; Tenni, Ruggero; Gruppi, Cristian; Tira, Maria Enrica

2008-07-10

336

Arabidopsis thaliana transgenics overexpressing IBR3 show enhanced susceptibility to the bacterium Pseudomonas syringae.  

UK PubMed Central (United Kingdom)

The gene, indole-3-butyric acid (IBA)-RESPONSE (IBR) 3, is thought to participate in peroxisomal ?-oxidation of IBA to indole-3-acetic acid. Here we show that IBR3 may also play a role in Arabidopsis thaliana defence response to microbial pathogens. IBR3 is up-regulated during infection by virulent Pseudomonas syringae pv. tomato (Pst) DC3000 bacteria. Although mutant ibr3-4 did not show a pathogen phenotype, lines overexpressing IBR3 demonstrated enhanced susceptibility to Pst DC3000. Increased susceptibility phenotypes of IBR3 overexpressors were correlated with defective SA defence signalling and impairment of pattern-triggered immunity (PTI) activation. Notably, reactive oxygen species production was reduced in IBR3 overexpressors after treatment with the microbe-associated molecular patterns flg22 and efl26. Later PTI responses, such as accumulation of FRK1 transcripts and callose deposition were also reduced in transgenics overexpressing IBR3 after inoculation with the Type III secretion system deficient bacterial mutant Pst DC3000 hrcC or treatment with flg22 or elf26. Importantly, overexpression of IBR3 did not affect indole-3-acetic acid content or auxin-responsive gene expression. These results suggest a novel role for IBR3 in A. thaliana defence response against bacterial pathogens.

Huang TY; Desclos-Theveniau M; Chien CT; Zimmerli L

2013-09-01

337

Mice vaccinated with enteropathogenic Escherichia coli ghosts show significant protection against lethal challenges.  

UK PubMed Central (United Kingdom)

Aim:? To prepare enteropathogenic Escherichia coli (EPEC) E2348/69 ghosts and investigate whether immunization with EPEC bacterial ghosts can elicit protective immune responses. Methods and Results:? A recombinant plasmid with double ?PL/PR-cI857 temperature-sensitive regulatory cassettes was constructed. The lysis gene E and/or the staphylococcal nuclease A (SNA) gene were separately inserted downstream of the two regulatory cassettes to construct the lysis plasmids pBV220::E and pBV220::E::CI-P-SNA. An EPEC reference strain E2348/69 (serotype O127:H6) was transformed with the lysis plasmids to produce EPEC ghosts. Mice injected with bacterial ghosts EGE (EPEC ghosts produced using lysis protein E) or EGES (EPEC ghosts produced using a combination of lysis protein E and SNA) gained weight normally and showed no clinical signs of disease. Vaccination trials showed that mice immunized with EGE or EGES were significantly protected against subsequent challenge with the wild-type virulent parent strain, EPEC E2348/69 (42/50 and 45/50 survival, respectively); in contrast, none of the 30 control mice survived. Conclusions:? Immunization with EPEC ghosts can elicit protective immune responses in BALB/c mice. Significance and Impact of the Study:? EPEC ghosts may represent a promising new approach for vaccination against EPEC infection.

Liu J; Wang WD; Liu YJ; Liu S; Zhou B; Zhu LW; Ji X; Sun Y; Feng SZ

2012-01-01

338

Mice vaccinated with enteropathogenic Escherichia coli ghosts show significant protection against lethal challenges.  

UK PubMed Central (United Kingdom)

AIM: To prepare enteropathogenic Escherichia coli (EPEC) E2348/69 ghosts and investigate whether immunization with EPEC bacterial ghosts can elicit protective immune responses. METHODS AND RESULTS: A recombinant plasmid with double ?PL/PR-cI857 temperature-sensitive regulatory cassettes was constructed. The lysis gene E and/or the staphylococcal nuclease A (SNA) gene were separately inserted downstream of the two regulatory cassettes to construct the lysis plasmids pBV220::E and pBV220::E::CI-P-SNA. An EPEC reference strain E2348/69 (serotype O127:H6) was transformed with the lysis plasmids to produce EPEC ghosts. Mice injected with bacterial ghosts EGE (EPEC ghosts produced using lysis protein E) or EGES (EPEC ghosts produced using a combination of lysis protein E and SNA) gained weight normally and showed no clinical signs of disease. Vaccination trials showed that mice immunized with EGE or EGES were significantly protected against subsequent challenge with the wild-type virulent parent strain, EPEC E2348/69 (42/50 and 45/50 survival, respectively); in contrast, none of the 30 control mice survived. CONCLUSIONS: Immunization with EPEC ghosts can elicit protective immune responses in BALB/c mice. SIGNIFICANCE AND IMPACT OF THE STUDY: EPEC ghosts may represent a promising new approach for vaccination against EPEC infection.

Liu J; Wang WD; Liu YJ; Liu S; Zhou B; Zhu LW; Ji X; Sun Y; Feng SZ

2012-03-01

339

MRI shows more severe hippocampal atrophy and shape deformation in hippocampal sclerosis than in Alzheimer's disease.  

UK PubMed Central (United Kingdom)

While hippocampal atrophy is a key feature of both hippocampal sclerosis (HS) and Alzheimer's disease (AD), the pathology underlying this finding differs in these two conditions. In AD, atrophy is due primarily to loss of neurons and neuronal volume as a result of neurofibrillary tangle formation. While the etiology of HS is unknown, neuron loss in the hippocampus is severe to complete. We compared hippocampal volume and deformations from premortem MRI in 43 neuropathologically diagnosed cases of HS, AD, and normal controls (NC) selected from a longitudinal study of subcortical ischemic vascular disease (IVD Program Project). HS cases (n = 11) showed loss of neurons throughout the rostral-caudal extent of the hippocampus in one or both hemispheres. AD cases (n = 24) met NIA-Reagan criteria for high likelihood of AD. Normal control cases (n = 8) were cognitively intact and showed no significant AD or hippocampal pathology. The mean hippocampal volumes were significantly lower in HS versus AD groups (P < .001). Mean shape deformations in the CA1 and subiculum differed significantly between HS versus AD, HS versus NC, and AD versus NC (P < .0001). Additional study is needed to determine whether these differences will be meaningful for clinical diagnosis of individual cases.

Zarow C; Wang L; Chui HC; Weiner MW; Csernansky JG

2011-01-01

340

Vitamin E Derivative Alpha-Tocotrienol Failed to Show Neuroprotective Effects after Embolic Stroke in Rats  

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Full Text Available Objective(s)Previous studies have demonstrated that pretreatment with alpha-tocotrienol (?-TCT) can reduce ischemic damage in mice following middle cerebral artery (MCA) occlusion. It is also reported to decrease stroke-dependent brain tissue damage in 12-Lox-deficient mice and spontaneously hypertensive rats. In the present study, the neuroprotective effects of ?-TCT and rosiglitazone (RGZ) at 3 hr after cerebral ischemia were investigated. Materials and MethodsStroke was induced by embolizing a preformed clot into the MCA. Rats were assigned to vehicle, ?-TCT (1 or 10 mg/kg), RGZ and sham-operation. ResultsCompared to the control group, only RGZ decreased infarct volume (P<0.05), neurological deficits (P<0.05) and sensory impairments (P<0.01) but low and high doses of ?-TCT did not show any significant neuroprotective effect. ConclusionOur data showed that ?-TCT was not neuroprotective at 3 hr after the embolic model of stroke. Further studies should be undertaken to clarify the neuroprotective effects of ?-TCT after stroke.

Mohammad Allahtavakoli; Aliasghar Pourshanazari; Behnam Heshmatian

2009-01-01

 
 
 
 
341

Bacterial biofilm shows persistent resistance to liquid wetting and gas penetration.  

UK PubMed Central (United Kingdom)

Most of the world's bacteria exist in robust, sessile communities known as biofilms, ubiquitously adherent to environmental surfaces from ocean floors to human teeth and notoriously resistant to antimicrobial agents. We report the surprising observation that Bacillus subtilis biofilm colonies and pellicles are extremely nonwetting, greatly surpassing the repellency of Teflon toward water and lower surface tension liquids. The biofilm surface remains nonwetting against up to 80% ethanol as well as other organic solvents and commercial biocides across a large and clinically important concentration range. We show that this property limits the penetration of antimicrobial liquids into the biofilm, severely compromising their efficacy. To highlight the mechanisms of this phenomenon, we performed experiments with mutant biofilms lacking ECM components and with functionalized polymeric replicas of biofilm microstructure. We show that the nonwetting properties are a synergistic result of ECM composition, multiscale roughness, reentrant topography, and possibly yet other factors related to the dynamic nature of the biofilm surface. Finally, we report the impenetrability of the biofilm surface by gases, implying defense capability against vapor-phase antimicrobials as well. These remarkable properties of B. subtilis biofilm, which may have evolved as a protection mechanism against native environmental threats, provide a new direction in both antimicrobial research and bioinspired liquid-repellent surface paradigms.

Epstein AK; Pokroy B; Seminara A; Aizenberg J

2011-01-01

342

Plant extracts from central Asia showing antiinflammatory activities in gene expression assays.  

UK PubMed Central (United Kingdom)

Plant natural products remain a good resource for the discovery of novel pharmaceuticals. A mouse macrophage-based quantitative, reverse transcription polymerase chain reaction (qRT-PCR) system was optimized to screen plant extracts for antiinflammatory activities using three well known genetic markers of inflammation. Plants used for extraction were taxonomically identified and vouchered species from two Central Asian countries, Uzbekistan and Kyrgyzstan, collected through the International Cooperative Biodiversity Groups (ICBG) program. The mRNA expression of cyclooxygenase-2, interleukin 1beta and inducible nitric oxide synthase genes in RAW macrophages was determined quantitatively in response to treatment with plant extracts applied at 100 microg/mL. The screening of 1000 extracts from 449 plant species belonging to 68 plant families resulted in 75 extracts (7.5%) showing strong (75% or higher inhibition) activity against at least one target gene. Many extracts showed qualitative and quantitative differences in the levels of activities against each target gene. Extracts identified from this screen were able to reduce inflammatory symptoms in vivo, thereby validating the screening approach.

Dey M; Ripoll C; Pouleva R; Dorn R; Aranovich I; Zaurov D; Kurmukov A; Eliseyeva M; Belolipov I; Akimaliev A; Sodombekov I; Akimaliev D; Lila MA; Raskin I

2008-07-01

343

Assessment of sun safety behavior among farmers attending a regional farm show in North Carolina.  

UK PubMed Central (United Kingdom)

BACKGROUND: Due to the nature of working outdoors, many farmers experience high levels of exposure to ultraviolet radiation (UVR) whereby, increasing their risk for skin cancer. The primary goal of this study was to evaluate personal behavior and perception on sun protection among farmers attending a regional farm show in North Carolina. METHODS: Farmers (n = 397) were asked to complete a self-administered questionnaire regarding behavior and importance of using personal sun protection (i.e., sunblock, etc.,) when working outdoors. RESULTS: There were 285 (71.8%) male farmers and 79 (19.9%) female farmers with a mean age of 54 years. Overall, the majority of farmers recognized the importance of protecting themselves from the sun, however, actual personal behavior for using proper protection methods ranked low. Farmers with lighter, fairer skin tended to use more sun protection and ranked the importance of sun protection higher when compared to those with skin that was less likely to burn in the sun. CONCLUSION: The importance of personal sun protection should continue to be stressed to farmers at every available opportunity including farm shows, trainings and through health care providers.

Kearney GD; Lea CS; Balanay J; Wu Q; Bethel JW; Von Hollen H; Sheppard K; Tutor-Marcom R; Defazio J

2013-01-01

344

Populations of Symbiodinium muscatinei show strong biogeographic structuring in the intertidal anemone Anthopleura elegantissima.  

Science.gov (United States)

Among temperate cnidarian symbioses, the partnership between the intertidal anemone Anthopleura elegantissima and its dinoflagellate and chlorophyte symbionts is one of the most well characterized. Biogeographic, reciprocal transplant, and physiological studies have convincingly demonstrated a relationship between environmental factors such as temperature and irradiance and the distribution of symbionts from both algal phyla. However, little is known about the fine-scale diversity or biogeographic distribution within symbiont lineages of this anemone. We used sequence information from the mitochondrial cytochrome b and chloroplast 23S ribosomal genes and restriction fragment length polymorphism data from the 18S nuclear ribosomal gene to characterize the Symbiodinium populations in tentacles clipped from 105 anemones at 14 sites along the entire California coast, spanning about 1200 km. Our results show the presence of at least three primary biogeographic regions with breaks around Cape Mendocino and Monterey Bay, each dominated by a different Symbiodinium muscatinei genotype. Sharp clines suggest limited gene flow between adjacent regions. Few sampling locations or individual anemones showed symbiont diversity at either organellar locus within the limits of our detection method, while sequence analysis of cloned nr18S polymerase chain reaction product suggests that nuclear pseudogenes may underlie intra-host diversity observed at that locus. PMID:21712228

Sanders, Jon G; Palumbi, Stephen R

2011-06-01

345

Populations of Symbiodinium muscatinei show strong biogeographic structuring in the intertidal anemone Anthopleura elegantissima.  

UK PubMed Central (United Kingdom)

Among temperate cnidarian symbioses, the partnership between the intertidal anemone Anthopleura elegantissima and its dinoflagellate and chlorophyte symbionts is one of the most well characterized. Biogeographic, reciprocal transplant, and physiological studies have convincingly demonstrated a relationship between environmental factors such as temperature and irradiance and the distribution of symbionts from both algal phyla. However, little is known about the fine-scale diversity or biogeographic distribution within symbiont lineages of this anemone. We used sequence information from the mitochondrial cytochrome b and chloroplast 23S ribosomal genes and restriction fragment length polymorphism data from the 18S nuclear ribosomal gene to characterize the Symbiodinium populations in tentacles clipped from 105 anemones at 14 sites along the entire California coast, spanning about 1200 km. Our results show the presence of at least three primary biogeographic regions with breaks around Cape Mendocino and Monterey Bay, each dominated by a different Symbiodinium muscatinei genotype. Sharp clines suggest limited gene flow between adjacent regions. Few sampling locations or individual anemones showed symbiont diversity at either organellar locus within the limits of our detection method, while sequence analysis of cloned nr18S polymerase chain reaction product suggests that nuclear pseudogenes may underlie intra-host diversity observed at that locus.

Sanders JG; Palumbi SR

2011-06-01

346

Attitude toward obesity showed by the teacher-training pupils of the University of Huelva  

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Full Text Available The present study analyses the attitude toward the obesity and the overweight that show the pupils of first and third course of the University of Huelva (N= 299) comparing the students of physical education (N= 123) with the students of kindergarten and primary education (N= 176). This design supposes a replication of the investigation made by O’Brien, Hunter and Banks (2006), who compared the attitude toward the obesity between one group of students of physical education and another group that studies psychology. In order to measure the attitude toward the obesity, explicit and implicit instruments, together with a questionnaire of physical-sport habits were used. The results confirm that all the pupils present a negative attitude toward the obesity and the overweight, being higher in the students of physical education, and among these higher in the pupils of third course. On the other hand, the pupils that show more interest toward the sport, and those students that practice more sports, possess a higher negative attitude toward the obesity and the overweight that those students that are not interested in or don’t practice sport

Gago Sampedro, Juan; Tornero Quiñones, Inmaculada; Carmona Márquez, José; Sierra Robles, Ángela

2012-01-01

347

Induced pluripotent stem cells from patients with Huntington's disease show CAG-repeat-expansion-associated phenotypes.  

UK PubMed Central (United Kingdom)

Huntington's disease (HD) is an inherited neurodegenerative disorder caused by an expanded stretch of CAG trinucleotide repeats that results in neuronal dysfunction and death. Here, The HD Consortium reports the generation and characterization of 14 induced pluripotent stem cell (iPSC) lines from HD patients and controls. Microarray profiling revealed CAG-repeat-expansion-associated gene expression patterns that distinguish patient lines from controls, and early onset versus late onset HD. Differentiated HD neural cells showed disease-associated changes in electrophysiology, metabolism, cell adhesion, and ultimately cell death for lines with both medium and longer CAG repeat expansions. The longer repeat lines were however the most vulnerable to cellular stressors and BDNF withdrawal, as assessed using a range of assays across consortium laboratories. The HD iPSC collection represents a unique and well-characterized resource to elucidate disease mechanisms in HD and provides a human stem cell platform for screening new candidate therapeutics.

2012-08-01

348

Induced Pluripotent Stem Cells from Patients with Huntington's Disease Show CAG Repeat Expansion Associated Phenotypes  

Science.gov (United States)

Huntington's disease (HD) is an inherited neurodegenerative disorder caused by an expanded stretch of CAG trinucleotide repeats that results in neuronal dysfunction and death. Here, the HD consortium reports the generation and characterization of 14 induced pluripotent stem cell (iPSC) lines from HD patients and controls. Microarray profiling revealed CAG expansion-associated gene expression patterns that distinguish patient lines from controls, and early onset versus late onset HD. Differentiated HD neural cells showed disease associated changes in electrophysiology, metabolism, cell adhesion, and ultimately cell death for lines with both medium and longer CAG repeat expansions. The longer repeat lines were however the most vulnerable to cellular stressors and BDNF withdrawal using a range of assays across consortium laboratories. The HD iPSC collection represents a unique and well-characterized resource to elucidate disease mechanisms in HD and provides a novel human stem cell platform for screening new candidate therapeutics.

Mattis, Virginia B; Svendsen, Soshana P; Ebert, Allison; Svendsen, Clive N; King, Alvin R; Casale, Malcolm; Winokur, Sara T; Batugedara, Gayani; Vawter, Marquis; Donovan, Peter J; Lock, Leslie F; Thompson, Leslie M; Zhu, Yu; Fossale, Elisa; Singh Atwal, Ranjit; Gillis, Tammy; Mysore, Jayalakshmi; Li, Jian-hong; Seong, IhnSik; Shen, Yiping; Chen, Xiaoli; Wheeler, Vanessa C; MacDonald, Marcy E; Gusella, James F; Akimov, Sergey; Arbez, Nicolas; Juopperi, Tarja; Ratovitski, Tamara; Chiang, Jason H; Kim, Woon Roung; Chighladze, Eka; Watkin, Erin; Zhong, Chun; Makri, Georgia; Cole, Robert N; Margolis, Russell L; Song, Hongjun; Ming, Guoli; Ross, Christopher A; Kaye, Julia A; Daub, Aaron; Sharma, Punita; Mason, Amanda R; Finkbeiner, Steven; Yu, Junying; Thomson, James A; Rushton, David; Brazier, Stephen P; Battersby, Alysia A; Redfern, Amanda; Tseng, Hsui-Er; Harrison, Alexander W; Kemp, Paul J; Allen, Nicholas D; Onorati, Marco; Castiglioni, Valentina; Cattaneo, Elena; Arjomand, Jamshid

2013-01-01

349

Canonical Wnts, specifically Wnt-10b, show ability to maintain dermal papilla cells.  

Science.gov (United States)

Although Wnts are expressed in hair follicles (HFs) and considered to be crucial for maintaining dermal papilla (DP) cells, the functional differences among them remain largely unknown. In the present study, we investigated the effects of Wnts (Wnt-3a, 5a, 10b, 11) on the proliferation of mouse-derived primary DP cells in vitro as well as their trichogenesis-promoting ability using an in vivo skin reconstitution protocol. Wnt-10b promoted cell proliferation and trichogenesis, while Wnt-3a showed those abilities to a limited extent, and Wnt-5a and 11 had no effects. Furthermore, we investigated the effects of these Wnts on cultured DP cells obtained from versican-GFP transgenic mice and found that Wnt-10b had a potent ability to sustain their GFP-positivity. These results suggest that canonical Wnts, specifically Wnt-10b, play important roles in the maintenance of DP cells and trichogenesis. PMID:23916705

Ouji, Yukiteru; Nakamura-Uchiyama, Fukumi; Yoshikawa, Masahide

2013-08-02

350

Attendees Preference Modelling for an International Art Festival Based on Show Attendances  

Directory of Open Access Journals (Sweden)

Full Text Available Falassi (1997) regards festivals as a time of celebration. Can festivalsbe considered catalysts for experiencinglocal art and culture or do they serve to promote an internationalised version of culture? This paper explores therole of arts festivals on local cultural consumption through festival attendees’ preferences to particular styles ofcultural performances. Using data from the 2009 Hong Kong Arts Festival the paper seeks to identify the factorsunderlining attendee preferences. Findings show that there is a demand for a balance of local and internationalcultural experiences. This result highlights the dual role of major festivals of both bringing the best ofinternational art to local residents while also showcasing the traditional and contemporary culture of the region.

Stephen Boyle; Carmen Joham; ABM Abdullah

2012-01-01

351

Metachronous metastasis- and survival-analysis show prognostic importance of lymphadenectomy for colon carcinomas  

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Full Text Available Abstract Background Lymphadenectomy is performed to assess patient prognosis and to prevent metastasizing. Recently, it was questioned whether lymph node metastases were capable of metastasizing and therefore, if lymphadenectomy was still adequate. We evaluated whether the nodal status impacts on the occurrence of distant metastases by analyzing a highly selected cohort of colon cancer patients. Methods 1,395 patients underwent surgery exclusively for colon cancer at the University of Lübeck between 01/1993 and 12/2008. The following exclusion criteria were applied: synchronous metastasis, R1-resection, prior/synchronous second carcinoma, age Results Five-year survival rates for TM + and TM- were 21% and 73%, respectively (p Conclusions Besides a higher T-category, a positive N-stage independently implies a higher probability to develop distant metastases and correlates with poor survival. Our data thus show a prognostic relevance of lymphadenectomy which should therefore be retained until conclusive studies suggest the unimportance of lmyphadenectomy.

Laubert Tilman; Habermann Jens K; Hemmelmann Claudia; Kleemann Markus; Oevermann Elisabeth; Bouchard Ralf; Hildebrand Philipp; Jungbluth Thomas; Bürk Conny; Esnaashari Hamed; Schlöricke Erik; Hoffmann Martin; Ziegler Andreas; Bruch Hans-Peter; Roblick Uwe J

2012-01-01

352

LEADING THE WAY AND SHOWING AFFILIATION: PARTICIPATORY ROLES IN A SEMI-STRUCTURED NARRATIVE INTERVIEW  

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Full Text Available This paper outlines the participatory roles of narrators and interviewers in the process of unfolding personal stories. Fifteen secondary school students of Hispanic-Australian background enrolled in intermediate Spanish classes in Melbourne (Australia) were asked to talk about a series of topics allowing them to explore and develop personal stories. For the purpose of providing a comprehensive corpus this manuscript focuses on the 11 personal stories that emerged in Spanish and English around the topic of ‘the worst holiday’. The results show that narratives are not initially volunteered by students, being prefaced by an initial denial of negative experience. Nevertheless, the interviewer’s participation dissipates the narrator’s initial attitude allowing students to construct narratives guided by the interviewer’s expectations. Interviewer strategies include requests for clarification, prompts for story development and co-authorship. Also crucial to the interaction is the use of laughter as a form of personal affiliation.

Katie Paredes; Marisa Cordella

2011-01-01

353

Antiparkinson drug--Mucuna pruriens shows antioxidant and metal chelating activity.  

Science.gov (United States)

Parkinson's disease is a neurodegenerative disorder for which no neurorestorative therapeutic treatment is currently available. Oxidative stress plays an important role in the pathophysiology of Parkinson's disease. The ancient Indian medical system, Ayurveda, traditionally uses Mucuna pruriens to treat Parkinson's disease. In our earlier studies, Mucuna pruriens has been shown to possess antiparkinson and neuroprotective effects in animal models of Parkinson's disease. The antioxidant activity of Mucuna pruriens was demonstrated by its ability to scavenge DPPH radicals, ABTS radicals and reactive oxygen species. Mucuna pruriens significantly inhibited the oxidation of lipids and deoxyribose sugar. Mucuna pruriens exhibited divalent iron chelating activity and did not show any genotoxic/mutagenic effect on the plasmid DNA. These results suggest that the neuroprotective and neurorestorative effect of Mucuna pruriens may be related to its antioxidant activity independent of the symptomatic effect. In addition, the drug appears to be therapeutically safe in the treatment of patients with Parkinson's disease. PMID:18064727

Dhanasekaran, Muralikrishnan; Tharakan, Binu; Manyam, Bala V

2008-01-01

354

Antiparkinson drug--Mucuna pruriens shows antioxidant and metal chelating activity.  

UK PubMed Central (United Kingdom)

Parkinson's disease is a neurodegenerative disorder for which no neurorestorative therapeutic treatment is currently available. Oxidative stress plays an important role in the pathophysiology of Parkinson's disease. The ancient Indian medical system, Ayurveda, traditionally uses Mucuna pruriens to treat Parkinson's disease. In our earlier studies, Mucuna pruriens has been shown to possess antiparkinson and neuroprotective effects in animal models of Parkinson's disease. The antioxidant activity of Mucuna pruriens was demonstrated by its ability to scavenge DPPH radicals, ABTS radicals and reactive oxygen species. Mucuna pruriens significantly inhibited the oxidation of lipids and deoxyribose sugar. Mucuna pruriens exhibited divalent iron chelating activity and did not show any genotoxic/mutagenic effect on the plasmid DNA. These results suggest that the neuroprotective and neurorestorative effect of Mucuna pruriens may be related to its antioxidant activity independent of the symptomatic effect. In addition, the drug appears to be therapeutically safe in the treatment of patients with Parkinson's disease.

Dhanasekaran M; Tharakan B; Manyam BV

2008-01-01

355

Serological evidences showing the involvement of free-living pheasants in the influenza ecology  

Directory of Open Access Journals (Sweden)

Full Text Available From 1995 to 2002, 219 sera were collected in Northern Italy from wild pheasants, in order to establish the possible involvement of these Galliformes birds in the influenza ecology. A serological survey for avian influenza viruses (AIVs) was carried out by ELISA test in order to detect type A influenza antibodies. The overall seroprevalence was 12.3%, with yearly values ranging from 0% to 42.5%. No antibodies against either H5 or H7 AIV subtypes were found by hemagglutination-inhibition test. Data from 16 recaptured birds, among 113 animals banded for individual identification, showed seroconversions in 2 pheasants. Our results indicate AIV circulation in free-living pheasants; the involvement of this land-based bird species in influenza ecology is discussed.

Maria Alessandra De Marco; Laura Campitelli; Mauro Delogu; Elisabetta Raffini; Emanuela Foni; Livia di Trani; Michele Scaffidi; Isabella Donatelli

2010-01-01

356

Dioecious Silene latifolia plants show sexual dimorphism in the vegetative stage  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract Background Prior to this study, no differences in gene expression between male and female dioecious plants in the vegetative state had been detected. Among dioecious plants displaying sexual dimorphism, Silene latifolia is one of the most studied species. Although many sexually dimorphic traits have been described in S. latifolia, all of them are quantitative, and they usually become apparent only after the initiation of flowering. Results We present RT-PCR-based evidence that in S. latifolia, sexual dimorphism in gene expression is present long before the initiation of flowering. We describe three ESTs that show sex-specific (two male specific and one female specific) transcription at the rosette stage before the first flowering season. Conclusions To our knowledge, this study provides the first molecular evidence of early pre-flowering sexual dimorphism in angiosperms.

Zluvova Jitka; Zak Jiri; Janousek Bohuslav; Vyskot Boris

2010-01-01

357

Similarity of scattering rates in metals showing T-linear resistivity.  

UK PubMed Central (United Kingdom)

Many exotic compounds, such as cuprate superconductors and heavy fermion materials, exhibit a linear in temperature (T) resistivity, the origin of which is not well understood. We found that the resistivity of the quantum critical metal Sr(3)Ru(2)O(7) is also T-linear at the critical magnetic field of 7.9 T. Using the precise existing data for the Fermi surface topography and quasiparticle velocities of Sr(3)Ru(2)O(7), we show that in the region of the T-linear resistivity, the scattering rate per kelvin is well approximated by the ratio of the Boltzmann constant to the Planck constant divided by 2?. Extending the analysis to a number of other materials reveals similar results in the T-linear region, in spite of large differences in the microscopic origins of the scattering.

Bruin JA; Sakai H; Perry RS; Mackenzie AP

2013-02-01

358

Radon in Irish Show Caves-Personal Monitoring Data From 2001-2006  

Science.gov (United States)

The European Directive 96/29/EURATOM and its transposition into national legislation demands the application of radiation protection measures if the presence of radon and radon decay products leads to significant increase in exposures of workers. Irish legislation further demands that laboratories carrying out radon measurements operate a high level quality assurance programme. As a result of a reconnaissance survey regular measurements of show cave guides have been made in order to assess exposure to radon in such workplaces and to ascertain that the limits set for radon are not exceeded. In 2000, an action level of 400 Bqm-3, was established. Doses in the range 0.3-12.0 mSv have been estimated for workers for the period 2001-2006.

Currivan, L.; Murray, M.; O'Colmain, M.; Pollard, D.

2008-08-01

359

Nav 1.8-null mice show stimulus-dependent deficits in spinal neuronal activity  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract Background The voltage gated sodium channel Nav 1.8 has a highly restricted expression pattern to predominantly nociceptive peripheral sensory neurones. Behaviourally Nav 1.8-null mice show an increased acute pain threshold to noxious mechanical pressure and also deficits in inflammatory and visceral, but not neuropathic pain. Here we have made in vivo electrophysiology recordings of dorsal horn neurones in intact anaesthetised Nav 1.8-null mice, in response to a wide range of stimuli to further the understanding of the functional roles of Nav 1.8 in pain transmission from the periphery to the spinal cord. Results Nav 1.8-null mice showed marked deficits in the coding by dorsal horn neurones to mechanical, but not thermal, -evoked responses over the non-noxious and noxious range compared to littermate controls. Additionally, responses evoked to other stimulus modalities were also significantly reduced in Nav 1.8-null mice where the reduction observed to pinch > brush. The occurrence of ongoing spontaneous neuronal activity was significantly less in mice lacking Nav 1.8 compared to control. No difference was observed between groups in the evoked activity to electrical activity of the peripheral receptive field. Conclusion This study demonstrates that deletion of the sodium channel Nav 1.8 results in stimulus-dependent deficits in the dorsal horn neuronal coding to mechanical, but not thermal stimuli applied to the neuronal peripheral receptive field. This implies that Nav 1.8 is either responsible for, or associated with proteins involved in mechanosensation.

Matthews Elizabeth A; Wood John N; Dickenson Anthony H

2006-01-01

360

Psychoacoustic tinnitus loudness and tinnitus-related distress show different associations with oscillatory brain activity.  

UK PubMed Central (United Kingdom)

BACKGROUND: The phantom auditory perception of subjective tinnitus is associated with aberrant brain activity as evidenced by magneto- and electroencephalographic studies. We tested the hypotheses (1) that psychoacoustically measured tinnitus loudness is related to gamma oscillatory band power, and (2) that tinnitus loudness and tinnitus-related distress are related to distinct brain activity patterns as suggested by the distinction between loudness and distress experienced by tinnitus patients. Furthermore, we explored (3) how hearing impairment, minimum masking level, and (4) psychological comorbidities are related to spontaneous oscillatory brain activity in tinnitus patients. METHODS AND FINDINGS: Resting state oscillatory brain activity recorded electroencephalographically from 46 male tinnitus patients showed a positive correlation between gamma band oscillations and psychoacoustic tinnitus loudness determined with the reconstructed tinnitus sound, but not with the other psychoacoustic loudness measures that were used. Tinnitus-related distress did also correlate with delta band activity, but at electrode positions different from those associated with tinnitus loudness. Furthermore, highly distressed tinnitus patients exhibited a higher level of theta band activity. Moreover, mean hearing loss between 0.125 kHz and 16 kHz was associated with a decrease in gamma activity, whereas minimum masking levels correlated positively with delta band power. In contrast, psychological comorbidities did not express significant correlations with oscillatory brain activity. CONCLUSION: Different clinically relevant tinnitus characteristics show distinctive associations with spontaneous brain oscillatory power. Results support hypothesis (1), but exclusively for the tinnitus loudness derived from matching to the reconstructed tinnitus sound. This suggests to preferably use the reconstructed tinnitus spectrum to determine psychoacoustic tinnitus loudness. Results also support hypothesis (2). Moreover, hearing loss and minimum masking level correlate with oscillatory power in distinctive frequency bands. The lack of an association between psychological comorbidities and oscillatory power may be attributed to the overall low level of mental health problems in the present sample.

Balkenhol T; Wallhäusser-Franke E; Delb W

2013-01-01

 
 
 
 
361

The common adolescent bipolar phenotype shows positive biases in emotional processing.  

UK PubMed Central (United Kingdom)

OBJECTIVES: Bipolar disorder is associated with abnormalities in emotional processing that persist into periods of remission. However, studies of euthymic bipolar disorder patients may be confounded by the experience of mood episodes and medication. We therefore assessed an adolescent group for vulnerability markers associated with the bipolar phenotype. METHODS: The Mood Disorder Questionnaire (MDQ) is a screening tool for bipolar disorder that targets mood-elevation symptoms. We selected 32 high-scoring students (? 7 symptoms) with the adolescent bipolar phenotype and 30 low-scoring controls (? 3 symptoms) and screened them with the Mini International Neuropsychiatric Interview-Plus for bipolar disorder and other psychiatric disorders. We investigated emotional processing by assessing facial expression recognition, emotional memory, emotion-potentiated startle, and a dot-probe task. RESULTS: Of the high-MDQ participants, 12 were in remission from bipolar disorder defined by DSM-IV-TR and interview (bipolar II disorder/bipolar disorder not otherwise specified) and 3 from major depressive disorder. High-MDQ participants had higher levels of neuroticism, low mood, and lifetime anxiety comorbidity and alcohol dependence compared with low-MDQ participants. The high-MDQ group showed facilitated recognition of surprised and neutral facial expressions and enhanced processing of positive versus negative information in emotional recognition memory and emotion-potentiated startle. There were no effects on emotional categorisation/recall memory or attentional bias in the dot-probe task. CONCLUSIONS: These results suggest that students with the common adolescent bipolar phenotype show positive emotional processing biases despite increased levels of neuroticism, low mood, and anxiety. Such effects may represent a psychological vulnerability marker associated with the bipolar phenotype.

Rock PL; Goodwin GM; Harmer CJ

2010-09-01

362

Lamotrigine augmentation in patients with schizophrenia who show partial response to clozapine treatment.  

UK PubMed Central (United Kingdom)

BACKGROUND: Several placebo controlled studies investigating lamotrigine augmentation of clozapine in schizophrenia patients with partial response have shown varying results. The aim of this study was to further investigate the efficacy and safety of this augmentation strategy, and its effect on the glutamatergic system through utilizing mismatch negativity (MMN) component of auditory event related potentials. METHODS: The study was designed to evaluate the efficacy and safety of lamotrigine augmentation of clozapine in a 12-week, double-blind, placebo-controlled, prospective, randomized design. Thirty-four patients diagnosed according to DSM-IV schizophrenia criteria and with partial response to clozapine were included. Patients were randomized to 25mg/day of lamotrigine or placebo, gradually increasing up to 200mg/day on the 6th week. The change in psychopathology was assessed with Positive and Negative Syndrome (PANSS), Calgary Depression (CDS) and Clinical Global Impression-Severity (CGI-S) scales. A neuropsychological test battery was administered and MMN measurements were also obtained at baseline and endpoint. Safety evaluation included physical examination, UKU Side Effect Rating Scale (UKU) assessment and serum drug level measurements. RESULTS: No significant differences were found between the two treatment groups in PANSS Positive and General Psychopathology, CDS, neurocognitive test and UKU scores, as well as MMN measurements. PANSS Total, Negative and CGI-S scores showed significant improvement compared to lamotrigine in the placebo group. CONCLUSION: This study did not show any benefit of augmentation of clozapine with lamotrigine in schizophrenia patients with partial response. The need for further investigation of other augmentation strategies of clozapine in partially responsive schizophrenia patients is evident.

Vay?so?lu S; An?l Ya?c?o?lu AE; Ya?c?o?lu S; Karahan S; Karc? O; Gürel SC; Yaz?c? MK

2013-01-01

363

Brain morphometry shows effects of long-term musical practice in middle-aged keyboard players.  

Science.gov (United States)

To what extent does musical practice change the structure of the brain? In order to understand how long-lasting musical training changes brain structure, 20 male right-handed, middle-aged professional musicians and 19 matched controls were investigated. Among the musicians, 13 were pianists or organists with intensive practice regimes. The others were either music teachers at schools or string instrumentalists, who had studied the piano at least as a subsidiary subject, and practiced less intensively. The study was based on T1-weighted MR images, which were analyzed using deformation-based morphometry. Cytoarchitectonic probabilistic maps of cortical areas and subcortical nuclei as well as myeloarchitectonic maps of fiber tracts were used as regions of interest to compare volume differences in the brains of musicians and controls. In addition, maps of voxel-wise volume differences were computed and analyzed. Musicians showed a significantly better symmetric motor performance as well as a greater capability of controlling hand independence than controls. Structural MRI-data revealed significant volumetric differences between the brains of keyboard players, who practiced intensively and controls in right sensorimotor areas and the corticospinal tract as well as in the entorhinal cortex and the left superior parietal lobule. Moreover, they showed also larger volumes in a comparable set of regions than the less intensively practicing musicians. The structural changes in the sensory and motor systems correspond well to the behavioral results, and can be interpreted in terms of plasticity as a result of intensive motor training. Areas of the superior parietal lobule and the entorhinal cortex might be enlarged in musicians due to their special skills in sight-playing and memorizing of scores. In conclusion, intensive and specific musical training seems to have an impact on brain structure, not only during the sensitive period of childhood but throughout life. PMID:24069009

Gärtner, H; Minnerop, M; Pieperhoff, P; Schleicher, A; Zilles, K; Altenmüller, E; Amunts, K

2013-09-23

364

A nude mouse model of hypertrophic scar shows morphologic and histologic characteristics of human hypertrophic scar.  

UK PubMed Central (United Kingdom)

Hypertrophic scar (HSc) is a fibroproliferative disorder that occurs following deep dermal injury. Lack of a relevant animal model is one barrier toward better understanding its pathophysiology. Our objective is to demonstrate that grafting split-thickness human skin onto nude mice results in survival of engrafted human skin and murine scars that are morphologically, histologically, and immunohistochemically consistent with human HSc. Twenty nude mice were xenografted with split-thickness human skin. Animals were euthanized at 30, 60, 120, and 180 days postoperatively. Eighteen controls were autografted with full-thickness nude mouse skin and euthanized at 30 and 60 days postoperatively. Scar biopsies were harvested at each time point. Blinded scar assessment was performed using a modified Manchester Scar Scale. Histologic analysis included hematoxylin and eosin, Masson's trichrome, toluidine blue, and picrosirius red staining. Immunohistochemistry included anti-human human leukocyte antigen-ABC, ?-smooth muscle actin, decorin, and biglycan staining. Xenografted mice developed red, shiny, elevated scars similar to human HSc and supported by blinded scar assessment. Autograft controls appeared morphologically and histologically similar to normal skin. Xenografts survived up to 180 days and showed increased thickness, loss of hair follicles, adnexal structures and rete pegs, hypercellularity, whorled collagen fibers parallel to the surface, myofibroblasts, decreased decorin and increased biglycan expression, and increased mast cell density. Grafting split-thickness human skin onto nude mice results in persistent scars that show morphologic, histologic, and immunohistochemical consistency with human HSc. Therefore, this model provides a promising technique to study HSc formation and to test novel treatment options.

Momtazi M; Kwan P; Ding J; Anderson CC; Honardoust D; Goekjian S; Tredget EE

2013-01-01

365

Results from OPERA  

Science.gov (United States)

In this report, the details of new ?? event detected by OPERA were reported. Also first result on ?? to ?e oscillation search in OPERA was described. The result excluded the high ?m2 region down to sin22?13˜2×10?2.

Nakamura, Mitsuhiro

2013-02-01

366

CDF Results on Diffraction  

CERN Multimedia

We report results on diffraction obtained by the CDF collaboration in p¯p collisions at the Fermilab Tevatron collider at ps = 1.96 TeV. The single diffractive dissociation processes such as diffractive dijet, W and Z productions are discussed. We also present results on double diffractive dissociation for central gap production. The first experimental observation of exclusive dijets is presented.

Mesropian, Christina

2010-01-01

367

Results from PETRA  

International Nuclear Information System (INIS)

A review of results from several PETRA experiments performed over the past year is presented. Results cover electroweak asymmetries, low thrust events with isolated muons, lifetime measurements for D, F and B mesons, charm production and QCD related studies. Inclusive muon production and heavy quark fragmentation are also discussed.

1986-08-08

368

Recent results from PEP  

International Nuclear Information System (INIS)

Recent results from PEP are presented. These include measurements of branching fractions, fragmentation properties and lifetimes of heavy flavored particle, measurements of the electroweak asymmetries in quark pair and lepton pair production in e+e-, and results on new particle serrches. 62 references, 50 figures.

1984-01-01

369

Overview of ALICE results  

CERN Multimedia

Selected ALICE results on the global event properties, particle spectra, azimuthal anisotropy, heavy flavour and quarkonium production in Pb-Pb collisions at sqrt(s_NN) = 2.76 TeV are presented. First results on p-Pb collisions at sqrt(s_NN) = 5.02 TeV are briefly reviewed.

Kryshen, E L

2013-01-01

370

Recent results from TRISTAN  

Energy Technology Data Exchange (ETDEWEB)

TRISTAN results on {gamma}{gamma} physics from 1994 to 1995 are reviewed in this report. We have systematically investigated jet production, the {gamma}-structure function, and charm pair production in {gamma}{gamma} processes. The results are discussed, and future prospects are presented.

Enomoto, Ryoji [National Laboratory for High Energy Physics, Ibaraki (Japan)

1997-01-01

371

Latest Results from PHOBOS  

CERN Multimedia

This manuscript contains a summary of the latest physics results from PHOBOS, as reported at Quark Matter 2006. Highlights include the first measurement from PHOBOS of dynamical elliptic flow fluctuations as well as an explanation of their possible origin, two-particle correlations, identified particle ratios, identified particle spectra and the latest results in global charged particle production.

Hofman, D J; Baker, M D; Ballintijn, M; Barton, D S; Betts, R R; Bickley, A A; Bindel, R; Busza, W; Carroll, A; Chai, Z; Chetluru, V; Decowski, M P; García, E; George, N; Gburek, T; Gulbrandsen, K; Halliwell, C; Hamblen, J; Harnarine, I; Hauer, M; Henderson, C; Hollis, R S; Holynski, R; Holzman, B; Iordanova, A; Johnson, E; Kane, J L; Khan, N; Kulinich, P; Kuo, C M; Li, W; Lin, W T; Loizides, C; Manly, S; Mignerey, A C; Nouicer, R; Olszewski, A; Pak, R; Reed, C; Richardson, E; Roland, C; Roland, G; Sagerer, J; Seals, H; Sedykh, I; Smith, C E; Stankiewicz, M A; Steinberg, P; Stephans, G S F; Sukhanov, A; Szostak, A; Tonjes, M B; Trzupek, A; Vale, C; van Nieuwenhuizen, G J; Vaurynovich, S S; Verdier, R; Veres, G I; Walters, P; Wenger, E; Willhelm, D; Wolfs, F L H; Wosiek, B; Wozniak, K; Wyngaardt, S; Wyslouch, B

2007-01-01

372

Diffraction Results from CDF  

Energy Technology Data Exchange (ETDEWEB)

We present final results by the CDF II collaboration on diffractive W and Z production, report on the status of ongoing analyses on diffractive dijet production and on rapidity gaps between jets, and briefly summarize results obtained on exclusive production pointing to their relevance to calibrating theoretical models used to predict exclusive Higgs-boson production at the LHC.

Goulianos, Konstantin

2012-04-01

373

Diffraction Results from CDF  

CERN Multimedia

We present final results by the CDF II collaboration on diffractive W and Z production, report on the status of ongoing analyses on diffractive dijet production and on rapidity gaps between jets, and briefly summarize results obtained on exclusive production pointing to their relevance to calibrating theoretical models used to predict exclusive Higgs-boson production at the LHC.

Goulianos, Konstantin

2012-01-01

374

Recent results from CDF  

Energy Technology Data Exchange (ETDEWEB)

A review of recent results from CDF is presented. The results are presently based on data samples of 19.3pb{sup -1} at a center-of-mass energy of 1.8 TeV. This includes the top quark search, the measurements of the W mass and width, and new particle searches. (author).

Chikamatsu, T. [Tsukuba Univ., Ibaraki (Japan). Inst. of Physics

1995-05-01

375

Vv-AMP1, a ripening induced peptide from Vitis vinifera shows strong antifungal activity  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract Background Latest research shows that small antimicrobial peptides play a role in the innate defense system of plants. These peptides typically contribute to preformed defense by developing protective barriers around germinating seeds or between different tissue layers within plant organs. The encoding genes could also be upregulated by abiotic and biotic stimuli during active defense processes. The peptides display a broad spectrum of antimicrobial activities. Their potent anti-pathogenic characteristics have ensured that they are promising targets in the medical and agricultural biotechnology sectors. Results A berry specific cDNA sequence designated Vv-AMP1, Vitis vinifera antimicrobial peptide 1, was isolated from Vitis vinifera. Vv-AMP1 encodes for a 77 amino acid peptide that shows sequence homology to the family of plant defensins. Vv-AMP1 is expressed in a tissue specific, developmentally regulated manner, being only expressed in berry tissue at the onset of berry ripening and onwards. Treatment of leaf and berry tissue with biotic or abiotic factors did not lead to increased expression of Vv-AMP1 under the conditions tested. The predicted signal peptide of Vv-AMP1, fused to the green fluorescent protein (GFP), showed that the signal peptide allowed accumulation of its product in the apoplast. Vv-AMP1 peptide, produced in Escherichia coli, had a molecular mass of 5.495 kDa as determined by mass spectrometry. Recombinant Vv-AMP1 was extremely heat-stable and showed strong antifungal activity against a broad spectrum of plant pathogenic fungi, with very high levels of activity against the wilting disease causing pathogens Fusarium oxysporum and Verticillium dahliae. The Vv-AMP1 peptide did not induce morphological changes on the treated fungal hyphae, but instead strongly inhibited hyphal elongation. A propidium iodide uptake assay suggested that the inhibitory activity of Vv-AMP1 might be associated with altering the membrane permeability of the fungal membranes. Conclusion A berry specific cDNA clone, Vv-AMP1, was isolated and characterized and shown to encode a plant defensin. Recombinant Vv-AMP1 displayed non-morphogenic antifungal activity against a broad spectrum of fungi, probably altering the membrane permeability of the fungal pathogens. The expression of this peptide is highly regulated in Vitis vinifera, hinting at an important defense role during berry-ripening.

de Beer Abré; Vivier Melané A

2008-01-01

376

Streamwater ages derived from tritium show power law variation with discharge like silica concentrations  

Science.gov (United States)

Understanding runoff generation is important for management of freshwater systems. Determining transit time distributions of streamwaters and how they change with discharge gives information on the flowpaths and recharge sources of streams - vital information for determining the responses of streams to stressors such as pollution, landuse change, or climate change. This work takes a first look at unique information on how transit time distributions change with discharge in some New Zealand catchments. Transit time distributions of streamwaters have been determined from tritium measurements on single samples in this work. This allows changes with stream discharge to be observed, in contrast to previous isotope studies which have given averaged transit time distributions based on series of samples. In addition, tritium reveals the wide spectrum of ages present in streams whereas oxygen-18 or chloride variations only show the younger ages (Stewart et al., 2010). It was found that the mean transit time (MTT) data could be reasonably represented by straight lines in log-log plots, indicating power law relationships between MTT and discharge. Similar power law behaviour has been observed for the rock forming elements such as silica in streamwaters (Godsey et al., 2009). Case studies are presented for two New Zealand catchments, both with volcanic ash substrates. Toenepi is a dairy catchment near Hamilton, which shows well-constrained power law relationships between MTT and discharge, and between silica concentration and discharge (Morgenstern et al., 2010). Baseflow MTTs vary from 2.5 to 157 years. Tutaeuaua is a pastoral farming catchment near Taupo. Results for nested catchments along the stream also show power law relationships for both MTT and silica with discharge. Streamwater MTTs vary from 1 to 11 years. The results indicate that (1) relatively old waters dominate many streams, (2) streamwater ages vary with discharge, and (3) age, like silica, varies according to power law relationships with stream discharge. References: Godsey, S.E., Kirchner, J.W., Clow, D.W. Hydrological Processes 23, 1844-1864, 2009. Morgenstern, U., Stewart M. K., Stenger, R. Hydrology and Earth System Sciences 14, 2289-2301, 2010. Stewart, M.K., Morgenstern, U., McDonnell, J.J. Hydrological Processes 24(12), 1646-1659, 2010.

Stewart, Michael; Morgenstern, Uwe

2013-04-01

377

LSND neutrino oscillation results  

International Nuclear Information System (INIS)

[en] In the past several years, a number of experiments have searched for neutrino oscillations, where a neutrino of one type (say bar ??) spontaneously transforms into a neutrino of another type (say bar ?e). For this phenomenon to occur, neutrinos must be massive and the apparent conservation law of lepton families must be violated. In 1995 the LSND experiment published data showing candidate events that are consistent with bar ?? oscillations. Additional data are reported here which provide stronger evidence for neutrino oscillations

1996-01-01

378

Tevatron physics results  

CERN Document Server

I will summarize the physics results from the Tevatron experiments with particular emphasis on the experimental methods used in different kinds of analysis. In particular, the Tevatron is a proton-antiproton collider that has now accumulated more than 2 fb^-1 of luminosity in the two experiments, called CDF and D0. In this lecture I will review the results on inclusive productions of jets, W- and Z-bosons, the results in the flavor sector, the measurements of top production, searches for Higgs boson production and searches for physics beyond the Standard Model. In each case I will explain the basic experimental concepts and methods needed for making the measurement.

CERN. Geneva

2007-01-01

379

Populations of Monarch butterflies with different migratory behaviors show divergence in wing morphology.  

Science.gov (United States)

The demands of long-distance flight represent an important evolutionary force operating on the traits of migratory species. Monarchs are widespread butterflies known for their annual migrations in North America. We examined divergence in wing morphology among migratory monarchs from eastern and western N. America, and nonmigratory monarchs in S. Florida, Puerto Rico, Costa Rica, and Hawaii. For the three N. American populations, we also examined monarchs reared in four common environment experiments. We used image analysis to measure multiple traits including forewing area and aspect ratio; for laboratory-reared monarchs we also quantified body area and wing loading. Results showed wild monarchs from all nonmigratory populations were smaller than those from migratory populations. Wild and captive-reared eastern monarchs had the largest and most elongated forewings, whereas monarchs from Puerto Rico and Costa Rica had the smallest and roundest forewings. Eastern monarchs also had the largest bodies and high measures of wing loading, whereas western and S. Florida monarchs had less elongated forewings and smaller bodies. Among captive-reared butterflies, family-level effects provided evidence that genetic factors contributed to variation in wing traits. Collectively, these results support evolutionary responses to long-distance flight in monarchs, with implications for the conservation of phenotypically distinct wild populations. PMID:20067519

Altizer, Sonia; Davis, Andrew K

2010-01-11

380

Populations of Monarch butterflies with different migratory behaviors show divergence in wing morphology.  

UK PubMed Central (United Kingdom)

The demands of long-distance flight represent an important evolutionary force operating on the traits of migratory species. Monarchs are widespread butterflies known for their annual migrations in North America. We examined divergence in wing morphology among migratory monarchs from eastern and western N. America, and nonmigratory monarchs in S. Florida, Puerto Rico, Costa Rica, and Hawaii. For the three N. American populations, we also examined monarchs reared in four common environment experiments. We used image analysis to measure multiple traits including forewing area and aspect ratio; for laboratory-reared monarchs we also quantified body area and wing loading. Results showed wild monarchs from all nonmigratory populations were smaller than those from migratory populations. Wild and captive-reared eastern monarchs had the largest and most elongated forewings, whereas monarchs from Puerto Rico and Costa Rica had the smallest and roundest forewings. Eastern monarchs also had the largest bodies and high measures of wing loading, whereas western and S. Florida monarchs had less elongated forewings and smaller bodies. Among captive-reared butterflies, family-level effects provided evidence that genetic factors contributed to variation in wing traits. Collectively, these results support evolutionary responses to long-distance flight in monarchs, with implications for the conservation of phenotypically distinct wild populations.

Altizer S; Davis AK

2010-04-01

 
 
 
 
381

HFE H63D mutation frequency shows an increase in Turkish women with breast cancer  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract Background The hereditary hemochromatosis gene HFE plays a pivotal role in iron homeostasis. The association between cancer and HFE hetero- or homozygosity has previously been shown including hepatocellular and nonhepatocellular malignancies. This study was performed to compare frequencies of HFE C282Y and H63D variants in Turkish women with breast cancer and healthy controls. Methods Archived DNA samples of Hacettepe University Oncology Institute were used in this study. The HFE gene was investigated by PCR-RFLP. Results All subjects studied were free from C282Y mutation. Thirty-nine patients had H63D mutation and were all heterozygous. H63D allele frequency was 22.2% (39/176) in the breast cancer patients, and 14% (28/200) in the healthy volunteers. Statistical analysis of cases with HFE H63D phenotype showed significant difference between breast cancer and healthy volunteers (P = 0.02). Conclusion Our results suggest that HFE H63D mutation frequencies were increased in the breast cancer patients in comparison to those in the general population. Also, odds ratios (odds ratio = 2.05) computed in this study suggest that H63D has a positive association with breast cancer.

Gunel-Ozcan Aysen; Aly?lmaz-Bekmez Sibel; Guler Emine; Guc Dicle

2006-01-01

382

Systematic review showed measures of individual burden of osteoarthritis poorly capture the patient experience.  

UK PubMed Central (United Kingdom)

OBJECTIVE: The objective of this study was to describe the content of questionnaires used in the assessment of the individual burden of osteoarthritis. STUDY DESIGN AND SETTING: A systematic search of computerized databases was conducted to identify self-report measures of osteoarthritis burden. The content of identified measures was assessed against the eight-domain Personal Burden of Osteoarthritis (PBO) model, which covers physical distress, fatigue, physical limitations, psychosocial distress, physical deconditioning, financial hardship, sleep disturbances, and lost productivity. The PBO was derived from extensive consultations with osteoarthritis patients and clinicians. RESULTS: A review of 5,703 publications identified 158 multi-item self-report measures of the individual burden of osteoarthritis. Content analysis showed that the dimensions of physical limitations, physical distress, and psychosocial distress were well represented by the identified questionnaires. The physical deconditioning and financial hardship dimensions were the least represented in the identified measures. The World Health Organization Quality of Life Scale gave the best coverage of PBO elements, with items matching seven of the eight PBO domains. CONCLUSION: Despite the large number of questionnaires identified, many aspects of the individual burden of osteoarthritis are not well represented by currently available measures. This may result in systematic gaps in how experiences of people with osteoarthritis are represented in research studies.

Busija L; Osborne RH; Roberts C; Buchbinder R

2013-08-01

383

Simvastatin treatment showed no prophylactic effect in influenza virus-infected mice.  

Science.gov (United States)

Simvastatin, a cholesterol-lowering drug, is reported to have immunomodulatory properties that attenuated acute lung injury independent of their major lipid lowering effects. Based on these reports, simvastatin is expected to be used for influenza prophylaxis and treatment. The present study evaluated the efficacy of simvastatin against influenza A/PR/8/34 virus infection in a murine model. In a first study, simvastatin was administered orally. To achieve high plasma levels, intraperitoneal application was used in a second study. Survival, body weight loss, viral titers in lung and trachea, and histologic lung injury were measured. Surprisingly, treatment with simvastatin resulted in lower survival rates and in more distinct body mass loss in comparison to virus-infected control mice. Furthermore, the viral load in lungs and tracheas as well as histopathological lesions were not reduced by simvastatin. Overall, these results showed that simvastatin failed to protect mice against influenza virus infection. J Med. Virol. 85:1978-1982, 2013. © 2013 Wiley Periodicals, Inc. PMID:23926054

Glück, Brigitte; Schmidtke, Michaela; Walther, Mario; Meerbach, Astrid; Wutzler, Peter

2013-08-07

384

Endodontic therapy of maxillary second molar showing an unusual internal anatomy  

Directory of Open Access Journals (Sweden)

Full Text Available Introduction: The knowledge of the complex anatomy of maxillary molars and location of extra canals are essential for diagnosis and endodontic treatment success. Objective: The purpose of this study was to report a clinical case showing a varying number of palatal roots in a second maxillary molar with the aid of operating microscope (OM). Case report: A four-rooted maxillary permanent second molar with 2 separated palatal canals undergone endodontic therapy. After endodontic access, examination of the chamber floor using an operating microscope revealed two distinct palatal canals orifices. A radiograph was taken after the working lengths of each canal were estimated by means of an electronic apex locator which clearly identified the four roots with independent four canals. The canals were instrumented with ProTaper™ rotatory instruments under irrigation with 5% sodium hypochlorite, obturated with Pulp Canal Sealer® and continue wave technique. After completion of root canal treatment, the tooth was restored with composite resin. Results: After endodontic access, the presence of two different palatal canals was found in a second maxillary molar, resulting from a variation in the number of palatal roots of this tooth. Conclusion: The high magnification and clear illumination quality provided by the dental operating microscope increase endodontic treatment success of the variations in the internal anatomy of the tooth.

Carlos Eduardo Fontana; Carolina Davoli Macedo Ibanéz; Felipe Davini; Alexandre Sigrist De Martin; Cláudia Fernandes de Magalhães Silveira; Daniel Guimarães Pedro Rocha; Carlos Eduardo da Silveira Bueno

2012-01-01

385

Vortexlet models of flapping flexible wings show tuning for force production and control  

Energy Technology Data Exchange (ETDEWEB)

Insect wings are compliant structures that experience deformations during flight. Such deformations have recently been shown to substantially affect induced flows, with appreciable consequences to flight forces. However, there are open questions related to the aerodynamic mechanisms underlying the performance benefits of wing deformation, as well as the extent to which such deformations are determined by the boundary conditions governing wing actuation together with mechanical properties of the wing itself. Here we explore aerodynamic performance parameters of compliant wings under periodic oscillations, subject to changes in phase between wing elevation and pitch, and magnitude and spatial pattern of wing flexural stiffness. We use a combination of computational structural mechanics models and a 2D computational fluid dynamics approach to ask how aerodynamic force production and control potential are affected by pitch/elevation phase and variations in wing flexural stiffness. Our results show that lift and thrust forces are highly sensitive to flexural stiffness distributions, with performance optima that lie in different phase regions. These results suggest a control strategy for both flying animals and engineering applications of micro-air vehicles.

Mountcastle, A M [Department of Organismic and Evolutionary Biology, Harvard University, Concord Field Station, Bedford, MA 01730 (United States); Daniel, T L, E-mail: mtcastle@u.washington.ed [Department of Biology, University of Washington, Seattle, WA 98195 (United States)

2010-12-15

386

Metabolic remodeling agents show beneficial effects in the dystrophin-deficient mdx mouse model  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract Background Duchenne muscular dystrophy is a genetic disease involving a severe muscle wasting that is characterized by cycles of muscle degeneration/regeneration and culminates in early death in affected boys. Mitochondria are presumed to be involved in the regulation of myoblast proliferation/differentiation; enhancing mitochondrial activity with exercise mimetics (AMPK and PPAR-delta agonists) increases muscle function and inhibits muscle wasting in healthy mice. We therefore asked whether metabolic remodeling agents that increase mitochondrial activity would improve muscle function in mdx mice. Methods Twelve-week-old mdx mice were treated with two different metabolic remodeling agents (GW501516 and AICAR), separately or in combination, for 4 weeks. Extensive systematic behavioral, functional, histological, biochemical, and molecular tests were conducted to assess the drug(s)' effects. Results We found a gain in body and muscle weight in all treated mice. Histologic examination showed a decrease in muscle inflammation and in the number of fibers with central nuclei and an increase in fibers with peripheral nuclei, with significantly fewer activated satellite cells and regenerating fibers. Together with an inhibition of FoXO1 signaling, these results indicated that the treatments reduced ongoing muscle damage. Conclusions The three treatments produced significant improvements in disease phenotype, including an increase in overall behavioral activity and significant gains in forelimb and hind limb strength. Our findings suggest that triggering mitochondrial activity with exercise mimetics improves muscle function in dystrophin-deficient mdx mice.

Jahnke Vanessa E; Van Der Meulen Jack H; Johnston Helen K; Ghimbovschi Svetlana; Partridge Terrence; Hoffman Eric P; Nagaraju Kanneboyina

2012-01-01

387

Vortexlet models of flapping flexible wings show tuning for force production and control  

International Nuclear Information System (INIS)

[en] Insect wings are compliant structures that experience deformations during flight. Such deformations have recently been shown to substantially affect induced flows, with appreciable consequences to flight forces. However, there are open questions related to the aerodynamic mechanisms underlying the performance benefits of wing deformation, as well as the extent to which such deformations are determined by the boundary conditions governing wing actuation together with mechanical properties of the wing itself. Here we explore aerodynamic performance parameters of compliant wings under periodic oscillations, subject to changes in phase between wing elevation and pitch, and magnitude and spatial pattern of wing flexural stiffness. We use a combination of computational structural mechanics models and a 2D computational fluid dynamics approach to ask how aerodynamic force production and control potential are affected by pitch/elevation phase and variations in wing flexural stiffness. Our results show that lift and thrust forces are highly sensitive to flexural stiffness distributions, with performance optima that lie in different phase regions. These results suggest a control strategy for both flying animals and engineering applications of micro-air vehicles.

2010-01-01

388

Identification and Characterisation CRN Effectors in Phytophthora capsici Shows Modularity and Functional Diversity.  

UK PubMed Central (United Kingdom)

Phytophthora species secrete a large array of effectors during infection of their host plants. The Crinkler (CRN) gene family encodes a ubiquitous but understudied class of effectors with possible but as of yet unknown roles in infection. To appreciate CRN effector function in Phytophthora, we devised a simple Crn gene identification and annotation pipeline to improve effector prediction rates. We predicted 84 full-length CRN coding genes and assessed CRN effector domain diversity in sequenced Oomycete genomes. These analyses revealed evidence of CRN domain innovation in Phytophthora and expansion in the Peronosporales. We performed gene expression analyses to validate and define two classes of CRN effectors, each possibly contributing to infection at different stages. CRN localisation studies revealed that P. capsici CRN effector domains target the nucleus and accumulate in specific sub-nuclear compartments. Phenotypic analyses showed that few CRN domains induce necrosis when expressed in planta and that one cell death inducing effector, enhances P. capsici virulence on Nicotiana benthamiana. These results suggest that the CRN protein family form an important class of intracellular effectors that target the host nucleus during infection. These results combined with domain expansion in hemi-biotrophic and necrotrophic pathogens, suggests specific contributions to pathogen lifestyles. This work will bolster CRN identification efforts in other sequenced oomycete species and set the stage for future functional studies towards understanding CRN effector functions.

Stam R; Jupe J; Howden AJ; Morris JA; Boevink PC; Hedley PE; Huitema E

2013-01-01

389

Modified Oleic Cottonseeds Show Altered Content, Composition and Tissue-Specific Distribution of Triacylglycerol Molecular Species.  

UK PubMed Central (United Kingdom)

Targeted increases in monounsaturated (oleic acid) fatty acid content of refined cottonseed oil could support improved human nutrition and cardiovascular health. Genetic modifications of cottonseed fatty acid composition have been accomplished using several different molecular strategies. Modification of oleic acid content in cottonseed embryos using a dominant-negative protein approach, while successful in effecting change in the desired fatty acid composition, resulted in reduced oil content and seed viability. Here these changes in fatty acid composition were associated with changes in dominant molecular species of triacylglycerols (TAGs) and their spatial distributions within embryo tissues. A combination of mass spectrometry (MS)- based lipidomics approaches, including MS imaging of seed cryo-sections, revealed that cotton embryos expressing a non-functional allele of a Brassica napus delta-12 desaturase showed altered accumulation of TAG species, especially within cotyledonary tissues. While lipid analysis of seed extracts could demonstrate detailed quantitative changes in TAG species in transgenics, the spatial contribution of metabolite compartmention could only be visualized by MS imaging. Our results suggest tissue-specific differences in TAG biosynthetic pathways within cotton embryos, and indicate the importance of considering the location of metabolites in tissues in addition to their identification and quantification when developing a detailed view of cellular metabolism.

Horn PJ; Sturtevant D; Chapman KD

2013-08-01

390

Antibiotic resistant mutants of Escherichia coli K12 show increases in heterologous gene expression.  

Science.gov (United States)

Using a variety of antibiotics, it was found that nine separate isolates of spontaneous antibiotic resistant mutants of Escherichia coli K12 pPSX-vioABCDE overproduce the anti-tumour antibiotic violacein. Subsequent analysis showed that seven of these mutations occurred on the plasmid pPSX-vioABCDE. The other two overproducing strains carried spontaneous chromosomal mutations to lincomycin and kanamycin. The kanamycin resistant mutant of E. coli K12 DH10B (AA23) and a lincomycin resistant mutant of E. coli K12 LE392 (AA24) increased the synthesis of violacein. The plasmid pPSX-vioABCDE opv-1 contains a violacein over-production (opv-1) mutation which when introduced into either E. coli K12 AA23 or AA24, resulted in a hyper-production of violacein. Remarkably, E. coli K12 AA23 pPSX-vioABCDE opv-1 produced 41 times the normal level of violacein. In addition, both E. coli K12 AA23 and E. coli K12 AA24 demonstrated an increase in expression of an alpha amylase gene from Streptomyces lividans and the urease gene cluster from Klebsiella oxytoca. These results suggest that selection of antibiotic resistant mutants can increase heterologous gene expression in E. coli K12. Additionally, the increased expression is a general effect applicable to genes and gene clusters cloned into E. coli K12 from both Gram-positive and Gram-negative bacteria. PMID:21087626

Ahmetagic, Adnan; Pemberton, John M

2010-11-16

391

Antibiotic resistant mutants of Escherichia coli K12 show increases in heterologous gene expression.  

UK PubMed Central (United Kingdom)

Using a variety of antibiotics, it was found that nine separate isolates of spontaneous antibiotic resistant mutants of Escherichia coli K12 pPSX-vioABCDE overproduce the anti-tumour antibiotic violacein. Subsequent analysis showed that seven of these mutations occurred on the plasmid pPSX-vioABCDE. The other two overproducing strains carried spontaneous chromosomal mutations to lincomycin and kanamycin. The kanamycin resistant mutant of E. coli K12 DH10B (AA23) and a lincomycin resistant mutant of E. coli K12 LE392 (AA24) increased the synthesis of violacein. The plasmid pPSX-vioABCDE opv-1 contains a violacein over-production (opv-1) mutation which when introduced into either E. coli K12 AA23 or AA24, resulted in a hyper-production of violacein. Remarkably, E. coli K12 AA23 pPSX-vioABCDE opv-1 produced 41 times the normal level of violacein. In addition, both E. coli K12 AA23 and E. coli K12 AA24 demonstrated an increase in expression of an alpha amylase gene from Streptomyces lividans and the urease gene cluster from Klebsiella oxytoca. These results suggest that selection of antibiotic resistant mutants can increase heterologous gene expression in E. coli K12. Additionally, the increased expression is a general effect applicable to genes and gene clusters cloned into E. coli K12 from both Gram-positive and Gram-negative bacteria.

Ahmetagic A; Pemberton JM

2011-01-01

392

Akt shows variable sensitivity to an Hsp90 inhibitor depending on cell context  

International Nuclear Information System (INIS)

Hsp90 inhibitors are currently in clinical trials for cancer therapy based on their ability to promote proteasomal degradation of oncogenic protein kinases and nuclear receptors. Results from recent studies suggest that cancer cells are more sensitive to these inhibitors than cells from healthy tissues. We analyzed an immortalized cell line Ba/F3 for sensitivity to the Hsp90 inhibitor geldanamycin in the absence and presence of the oncogenic tyrosine fusion kinase NPM-ALK expressed from a retroviral vector. Our results showed that NPM-ALK expression makes Akt and Cdk4 more resistant to degradation in the presence of geldanamycin, and there was a slightly reduced amount of apoptosis. The mechanism underlying the effect of NPM-ALK on Akt stability was probed by comparison of the turnover of the kinase after translation inhibition and geldanamycin treatment. We observed that Akt was degraded more rapidly in the presence of GA than upon translation inhibition without NPM-ALK expression. This suggests that NPM-ALK protects the mature kinase. Furthermore, Akt failed to bind to the Cdc37 chaperone in cells expressing NPM-ALK, which also correlates with increased Akt stability.

2007-11-01

393

Look, no hands: a perceptual task shows that number magnitude induces shifts of attention.  

UK PubMed Central (United Kingdom)

The mental representation of numbers along a line oriented left to right affects spatial cognition, facilitating responses in the ipsilateral hemispace (the spatial-numerical association of response codes [SNARC] effect). We investigated whether the number/space association is the result of an attentional shift or response selection. Previous research has often introduced covert left/right response cues by presenting targets to the left or the right. The present study avoided left/right cues by requiring forced choice upper/lower luminance discriminations to two mirror-reversed luminance gradients (the grayscale task). The grayscale stimuli were overlaid with strings of (1) low numbers, (2) high numbers, and (3) nonnumerical characters. In Experiment 1, 20 dextrals judged the number's magnitude and then indicated whether the upper/lower grayscale was darker. Results showed leftward and rightward attentional biases for low and high numbers, respectively. Demands to process numbers along a left/right line were made less explicit in Experiment 2 (N = 18 dextrals), using (1) a parity judgment and (2) arbitrary linguistic labels for top/bottom. Once again, a spatial congruency effect was observed. Because the response (up/down) was orthogonal to the dimension of interest (left/right), the effect of number cannot be attributed to late-stage response congruencies. This study required unspeeded responses to stimuli presented in free vision, whereas other experiments have used speeded responses. Understanding the time course of number-space effects may, therefore, be important to the debate associated with response selection.

Nicholls ME; Loftus AM; Gevers W

2008-04-01

394

Chronic myelogenous leukemia accompanied by megaloblastic anemia showing atypical clinical features.  

UK PubMed Central (United Kingdom)

Leukocytosis, splenomegaly, and an increased vitamin B(12) level are characteristic findings of chronic myelogenous leukemia in the chronic phase (CML-CP). Here, we report a patient with CML-CP accompanied by megaloblastic anemia. A 61-year-old man consulted our hospital because of anemia and thrombocytopenia. On physical examination, there were no remarkable findings; there was no hepatosplenomegaly. Laboratory findings were: hemoglobin 6.0 g/dl; MCV 113.6 fl; platelet count 100×10(9)/l; white cell count 8.66×10(9)/l; and LDH 1,236 IU/l. Peripheral blood smear demonstrated hypersegmented neutrophils and megalocytes with emergence of myeloblasts, giant metamyelocytes, and nucleated red cells. Vitamin B(12) and folic acid levels were low. Bone marrow examination showed megaloblastic change in the erythroblasts and myeloid hyperplasia. Following vitamin B(12) and folic acid administration, anemia and thrombocytopenia rapidly improved; thereafter, marked leukocytosis became evident. Based on the presence of t(9;22)(q34;q11) on cytogenetic study and a positive result for Major bcr/abl fusion gene, a diagnosis of CML-CP was established. This case illustrates that ineffective erythropoiesis results in anemia and thrombocytopenia in CML with vitamin B12 and/or folic acid deficiency.

Koiso H; Tsukamoto N; Shimano S; Karasawa M; Murakami H; Nojima Y

2011-11-01

395

Triploid and diploid Atlantic salmon show similar susceptibility to infection with salmon lice Lepeophtheirus salmonis.  

UK PubMed Central (United Kingdom)

BACKGROUND: Sea lice infection is the most expensive disease factor for Atlantic salmon sea-cage farming. For triploid salmon to be accepted as a commercial possibility, investigation of susceptibility of triploid salmon to sea lice infection is a fundamental milestone. The susceptibility of diploid and triploid salmon to infection with Lepeophtheirus salmonis was examined in a tank trial in Scotland, a tank trial in Norway and a cage trial in Scotland. RESULTS: Following a single infection challenge, results indicated a significant correlation between fish size and the number of attached sea lice. Triploid fish were larger than diploids at the smolt stage. In the tank trials, no difference was found between infection levels on diploids and triploids after a single infection challenge. The tank trial in Scotland continued with a second infection challenge of the same fish, which also showed no infection differences between ploidies. A borderline correlation between first infection and re-infection intensity was found for PIT-tagged diploid salmon examined after each challenge. No significant difference in louse infection between diploid and triploid salmon (~2?kg) was found in the cage trial undertaken under commercial conditions. CONCLUSION: This study concludes that triploid Atlantic salmon are not more susceptible to sea louse infection than diploid fish.

Frenzl B; Migaud H; Fjelldal PG; Shinn AP; Taylor JF; Richards RH; Glover KA; Cockerill D; Bron JE

2013-08-01

396

Liquid-infused slippery surfaces show marine anti-biofouling properties.  

UK PubMed Central (United Kingdom)

Marine biofouling is a longstanding problem due to the constant challenges placed by various fouling species and increasingly restricted environmental regulations for antifouling coatings. Novel non-biocidal strategies to control biofouling will necessitate a multifunctional approach to coatings design. Here we show that slippery liquid-infused porous surfaces (SLIPS) provide another possible strategy to obtain promising antifouling coatings. Microporous poly(butyl methacrylate-co-ethylene dimethacrylate) (BMA-EDMA) surfaces are prepared via UV-initiated free radical polymerization. Subsequent infusion of fluorocarbon lubricants (Krytox103, Krytox100 and Fluorinert FC-70) into the porous microtexture results in liquid-repellent slippery surfaces. To study the interaction with marine fouling organisms, settlement of zoospores of the alga Ulva linza and cypris larvae of the barnacle Balanus amphitrite is tested in laboratory assays. BMA-EDMA surfaces infused with Krytox103 and Krytox100 exhibit remarkable inhibition of settlement (attachment) of both spores and cyprids to a level comparable to that of a polyethylene glycol terminated (PEG) self-assembled monolayer. In addition, the adhesion strength of sporelings (young plants) of U. linza is reduced for BMA-EDMA surfaces infused with Krytox103 and Krytox100 compared to pristine (non-infused) BMA-EDMA and BMA-EDMA infused with Fluorinert FC-70. Immersion tests suggest a correlation between the stability of slippery coatings in artificial seawater and fouling resistance efficacy. The results indicate great potential for the application of this concept in fouling-resistant marine coatings.

Xiao L; Li J; Mieszkin S; Fino AD; Clare AS; Callow ME; Callow JA; Grunze M; Rosenhahn A; Levkin PA

2013-09-01

397

Simvastatin treatment showed no prophylactic effect in influenza virus-infected mice.  

UK PubMed Central (United Kingdom)

Simvastatin, a cholesterol-lowering drug, is reported to have immunomodulatory properties that attenuated acute lung injury independent of their major lipid lowering effects. Based on these reports, simvastatin is expected to be used for influenza prophylaxis and treatment. The present study evaluated the efficacy of simvastatin against influenza A/PR/8/34 virus infection in a murine model. In a first study, simvastatin was administered orally. To achieve high plasma levels, intraperitoneal application was used in a second study. Survival, body weight loss, viral titers in lung and trachea, and histologic lung injury were measured. Surprisingly, treatment with simvastatin resulted in lower survival rates and in more distinct body mass loss in comparison to virus-infected control mice. Furthermore, the viral load in lungs and tracheas as well as histopathological lesions were not reduced by simvastatin. Overall, these results showed that simvastatin failed to protect mice against influenza virus infection. J Med. Virol. 85:1978-1982, 2013. © 2013 Wiley Periodicals, Inc.

Glück B; Schmidtke M; Walther M; Meerbach A; Wutzler P

2013-11-01

398

Results From MWA  

Science.gov (United States)

The Murchison Widefield Array (MWA) is a US-Australia-India low frequency observatory optimized for Epoch of Reionization measurements. This talk will review the current state of the Murchison Widefield Array and showcase results from the 32 antenna prototype.

Morales, Miguel F.; MWA Collaboration

2011-01-01

399

Recent results from PETRA  

International Nuclear Information System (INIS)

Recent results on the search for new particles, new thresholds and on properties of B-mesons are reported. No new particle has been observed. More stringent limits on production cross sections have been obtained. (orig.)

1981-08-29

400

Tevatron direct photon results.  

Energy Technology Data Exchange (ETDEWEB)

Tevatron direct photon results since DIS98 are reviewed. Two new CDF measurements are dis