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Sample records for v-notch results show

  1. Results of charpy V-notch impact testing of structural steel specimens irradiated at ∼30 degrees C to 1 x 1016 neutrons/cm2 in a commercial reactor cavity

    A capsule containing Charpy V-notch (CVN) and mini-tensile specimens was irradiated at ∼ 30 degrees C (∼ 85 degrees F) in the cavity of a commercial nuclear power plant to a fluence of 1 x 1016 neutrons/cm2 (> 1MeV). The capsule included six CVN impact specimens of archival High Flux Isotope Reactor A212 grade B ferritic steel and five CVN impact specimens of a well-studied A36 structural steel. This irradiation was part of the ongoing study of neutron-induced damage effects at the low temperature and flux experienced by reactor supports. The plant operators shut down the plant before the planned exposure was reached. The exposure of these specimens produced no significant irradiation-induced embrittlement. Of interest were the data on unirradiated specimens in the L-T orientation machined from a single plate of A36 structural steel, which is the same specification for the structural steel used in some reactor supports. The average CVN energy of five unirradiated specimens obtained from one region of the plate and tested at room temperature was ∼ 99 J, while the energy of 11 unirradiated specimens from other locations of the same plate was 45 J, a difference of ∼ 220%. The CVN impact energies for all 18 specimens ranged from a low of 32 J to a high of 111 J. Moreover, it appears that the University of Kansas CVN impact energy data of the unirradiated specimens at the 100-J level are shifted toward higher temperatures by about 20 K. The results were an example of the extent of scatter possible in CVN impact testing. Generic values for the CVN impact energy of A36 should be used with caution in critical applications

  2. Results of charpy V-notch impact testing of structural steel specimens irradiated at {approximately}30{degrees}C to 1 x 10{sup 16} neutrons/cm{sup 2} in a commercial reactor cavity

    Iskander, S.K.; Stoller, R.E.

    1997-04-01

    A capsule containing Charpy V-notch (CVN) and mini-tensile specimens was irradiated at {approximately} 30{degrees}C ({approximately} 85{degrees}F) in the cavity of a commercial nuclear power plant to a fluence of 1 x 10{sup 16} neutrons/cm{sup 2} (> 1MeV). The capsule included six CVN impact specimens of archival High Flux Isotope Reactor A212 grade B ferritic steel and five CVN impact specimens of a well-studied A36 structural steel. This irradiation was part of the ongoing study of neutron-induced damage effects at the low temperature and flux experienced by reactor supports. The plant operators shut down the plant before the planned exposure was reached. The exposure of these specimens produced no significant irradiation-induced embrittlement. Of interest were the data on unirradiated specimens in the L-T orientation machined from a single plate of A36 structural steel, which is the same specification for the structural steel used in some reactor supports. The average CVN energy of five unirradiated specimens obtained from one region of the plate and tested at room temperature was {approximately} 99 J, while the energy of 11 unirradiated specimens from other locations of the same plate was 45 J, a difference of {approximately} 220%. The CVN impact energies for all 18 specimens ranged from a low of 32 J to a high of 111 J. Moreover, it appears that the University of Kansas CVN impact energy data of the unirradiated specimens at the 100-J level are shifted toward higher temperatures by about 20 K. The results were an example of the extent of scatter possible in CVN impact testing. Generic values for the CVN impact energy of A36 should be used with caution in critical applications.

  3. Effect of V Notch Shape on Fatigue Life in Steel Beam Made of AISI 1037

    Qasim Bader

    2014-04-01

    Full Text Available The present work encompasses effect of V notch shape with various geometries and dimensions on fatigue life behavior in steel beam made of Medium Carbon Steel AISI 1037 which has a wide application in industry. Fatigue life of notched specimens is calculated using the fatigue life obtained from the experiments for smooth specimens (reference and by use Numerical method (FEA.The fatigue experiments were carried out at room temperature, applying a fully reversed cyclic load with the frequency of (50Hz and mean stress equal to zero (R= -1, on a cantilever rotating-bending fatigue testing machine. The stress ratio was kept constant throughout the experiment. Different instruments have been used in this investigation like Chemical composition analyzer type (Spectromax ,Tensile universal testing machine type (WDW-100E ,Hardness tester type (HSV- 1000 , Fatigue testing machine model Gunt WP 140, Optical Light Microscope (OLM and Scanning Electron Microscope (SEM were employed to examine the fracture features . The results show that there is acceptable error between experimental and numerical works .

  4. Use of forces from instrumented Charpy V-notch testing to determine crack-arrest toughness

    The objective of this investigation is an estimation of the crack-arrest toughness, particularly of irradiated materials, from voltage versus time output of an instrumented setup during a test on a Charpy V-notch (CVN) specimen. This voltage versus time trace (which can be converted to force versus displacement) displays events during fracture of the specimen. Various stages of the fracture process can be identified on the trace, including an arrest point indicating arrest of brittle fracture. The force at arrest, Fa, versus test temperature, T, relationship is examined to explore possible relationships to other experimental measures of crack-arrest toughness such as the drop-weight nil-ductility temperature (NDT), or crack-arrest toughness, Ka. For a wide range of weld and plate materials, the temperature at which Fa = 2.45 kN correlates with NDT with a standard deviation, sigma, of about 11 K. Excluding the so-called low upper-shelf energy (USE) welds from the analysis resulted in Fa = 4.12 kN and σ = 6.6 K. The estimates of the correlation of the temperature for Fa = 7.4 kN with the temperature at 100-MPa√m level for a mean American Society of Mechanical Engineers (ASME) type KIa curve through crack-arrest toughness values show that prediction of conservative values of Ka are possible

  5. Critical Value for Crack Propagation from Sharp V-Notch

    Náhlík, Luboš; Štegnerová, Kateřina; Hutař, Pavel; Majer, Z.

    Zurich : Trans Tech Publications, 2014 - (Šandera, P.), s. 177-180 ISBN 978-3-03785-934-6. ISSN 1013-9826. - (Key Engineering Materials. 592-593). [MSMF 7 - International Conference on Materials Structure & Micromechanics of Fracture /7./. Brno (CZ), 01.07.2013-03.07.2013] R&D Projects: GA MŠk(CZ) EE2.3.20.0214 Grant ostatní: VUT(CZ) FSIJ- 13-2046 Institutional support: RVO:68081723 Keywords : V-notch * linear elastic fracture mechanics * stress singularity * generalized stress intensity factor * generalized strain energy density factor Subject RIV: JL - Materials Fatigue, Friction Mechanics

  6. Weld investigations by 3D analyses of Charpy V-notch specimens

    Tvergaard, Viggo; Needleman, Allan

    2005-01-01

    The Charpy impact test is a standard procedure for determining the ductile-brittle transition in welds. The predictions of such tests have been investigated by full three dimensional transient analyses of Charpy V-notch specimens. The material response is characterised by an elastic-viscoplastic ......The Charpy impact test is a standard procedure for determining the ductile-brittle transition in welds. The predictions of such tests have been investigated by full three dimensional transient analyses of Charpy V-notch specimens. The material response is characterised by an elastic......-viscoplastic constitutive relation for a porous plastic solid, accounting for adiabatic heating due to plastic dissipationfiand the resulting thermal softening. The onset of cleavage is taken to occur when the average of the maximum principal stress over a speci¯ed volume attains a critical value. Typically, the material...... parameters in the weld material differ from those in the base material, and the heat a®ected zone (HAZ) tends to be more brittle than the other material regions. The effect of weld strength undermatch or overmatch is an important issue. Some specimens, for which the notched surface is rotated relative to the...

  7. The complex potential approach to power-logarithmic stress singularities for V-notched cracks in a bi-material

    Power-logarithmic stress singularities and the coefficient vectors for V-notched cracks in a bi-material are obtained by using complex potentials and the concept of repeated roots for general solutions. On several examples, it is shown that the results obtained using the complex potential approach are identical to those found by Bogy (1970) using the Mellin transform method, and to those found by Dempsey and Sinclair (1979, 1981) using the Airy stress function approach

  8. Critical applied stresses for a crack initiation from a sharp V-notch

    L. Náhlík

    2014-10-01

    Full Text Available The aim of the paper is to estimate a value of the critical applied stress for a crack initiation from a sharp V-notch tip. The classical approach of the linear elastic fracture mechanics (LELM was generalized, because the stress singularity exponent differs from 0.5 in the studied case. The value of the stress singularity exponent depends on the V-notch opening angle. The finite element method was used for a determination of stress distribution in the vicinity of the sharp V-notch tip and for the estimation of the generalized stress intensity factor depending on the V-notch opening angle. Critical value of the generalized stress intensity factor was obtained using stability criteria based on the opening stress component averaged over a critical distance d from the V-notch tip and generalized strain energy density factor. Calculated values of the critical applied stresses were compared with experimental data from the literature and applicability of the LEFM concept is discussed.

  9. Effect of notch dimension on the fatigue life of V-notched structure

    Highlights: → A novel method is proposed to calculate the SIFs of crack at notch tip. → Effect of notch opening angle on the crack extension and propagation is studied. → Influence of notch depth on the crack extension and propagation is analyzed. → The fatigue life of a welded joint is analyzed by the present method. - Abstract: The stress singularity degree associated to a V-notch has a great influence on the fatigue life of V-notched structure. The growth rate of the crack initiated at the tip of a V-notch depends on the stress singularity of the V-notch. The fatigue life accompanying with this small crack will represent a large amount of the total fatigue life. In this work, boundary element method (BEM) is used to study the propagation of the crack emanating from a V-notch tip under fatigue loading. A comparison of the fatigue life between the crack initiated from V-notch tip and a lateral crack is done by a crack propagation law until these two cracks have the same stress intensity factors (SIFs). The effect of initial crack length, notch opening angle and notch depth on the crack extension and propagation is analyzed. As an example of engineering application, the fatigue life of a welded joint is investigated by the present method. The influence of weld toe angle and initial crack length on the fatigue life of the welded structure is studied. Some suggestions are given as an attempt to improve the fatigue life of welded structures at the end.

  10. CALIBRATION OF A 90 DEGREE V-NOTCH WEIR USING PARAMETERS OTHER THAN UPSTREAM HEAD

    Traditional calibration of 90 degrees V-Notch Weirs has involved the establishment of a head-discharge relationship where the head is measured upstream of weir drawdown effects. This parameter is often difficult to mesure in field weir installations. Two other parameters are prop...

  11. Influence of the V-notch opening angle on critical applied force values for the crack initiation from the sharp V-notch

    Štegnerová, Kateřina; Náhlík, Luboš; Hutař, Pavel

    Zürich : Trans Tech publications, 2015 - (Alfaiate, J.; Aliabadi, M.), s. 165-168 ISBN 978-3-03835-235-8. ISSN 1013-9826. - (Key Engineering Materials. 627). [FDM 2014 International Conference on Fracture and Damage Mechanics /13./. São Miguel Island, Azores (PT), 23.09.2014-25.09.2014] R&D Projects: GA MŠk(CZ) EE2.3.30.0063 Institutional support: RVO:68081723 Keywords : sharp V-notch * crack initiation * stress singularity * generalized stress intensity factor Subject RIV: JL - Materials Fatigue, Friction Mechanics www.scientific.net/KEM.627.165

  12. Analysis of the Charpy V-notch test for welds

    Tvergaard, Viggo; Needleman, A.

    2000-01-01

    The ductile-brittle transition for a weld is investigated by numerical analyses of Charpy impact specimens. The material response is characterized by an elastic-viscoplastic constitutive relation for a porous plastic solid, with adiabatic heating due to plastic dissipation and the resulting thermal...... softening accounted for. The onset of cleavage is taken to occur when a critical value of the maximum principal stress is attained. The effect of weld strength undermatch or overmatch is investigated for a comparison material, and analyses are also carried out based on experimentally determined flow...... strength variations in a weldment in a HY100 steel. The predicted work to fracture shows a strong sensitivity to the location of the notch relative to the weld, with the most brittle behavior for a notch close to the narrow heat affected zone. The analyses illustrate the strong dependence of the transition...

  13. Evaluation of fracture toughness in dental ceramics using indentation and SEVNB (Single Edge V-Notched Beam)-method

    In this work, the fracture toughness of different ceramics based on Al2O3 and ZrO2 were evaluated using, comparatively two methods, Vickers indentation and SEVNB (Single Edge V-Notched Beam) method. Al2O3, ZrO2(3%Y2O3) micro-particled and ZrO2(3%Y2O3) nanometric, ZrO2-Al2O3 and Al2O3-ZrO2 composites were sintered at different temperatures. Samples were characterized by relative density, X-ray diffraction, SEM, and mechanical evaluation by hardness, bending strength and fracture toughness obtained by ickers indentation and SEVNB-method. The results were presented comparing the densification and microstructural results. Furthermore, the advantages and limitations of each method were discussed. (author)

  14. Estimation of critical values for crack initiation from sharp V-notches

    Náhlík, Luboš; Štegnerová, Kateřina; Hutař, Pavel

    Brno : Brno University of Technology. Institute of Solid Mechanics, Mechatronics and Biomechanics, 2014 - (Fuis, V.), s. 412-415 ISBN 978-80-214-4871-1. ISSN 1805-8248. [Engineering Mechanics 2014 /20./. Svratka (CZ), 12.05.2014-15.05.2014] R&D Projects: GA MŠk(CZ) EE2.3.30.0063 Institutional support: RVO:68081723 Keywords : Failure initiation * stress singularity * V-notch * generalized stress intensity factor Subject RIV: JL - Materials Fatigue, Friction Mechanics

  15. Critical applied stresses for a crack initiation from a sharp V-notch

    Náhlík, Luboš; Hutař, Pavel; Štegnerová, Kateřina

    Vol. 8. Catania : Gruppo Italiano Frattura, 2014, s. 55-61. ISBN 978-88-95940-49-6. ISSN 1971-8993. - (30). [Fracture and Structural Integrity related Issues. Catania (IT), 15.09.2014-17.09.2014] R&D Projects: GA MŠk(CZ) EE2.3.30.0063; GA MŠk(CZ) EE2.3.20.0214 Institutional support: RVO:68081723 Keywords : Crack initiation * V-notch * critical stress * strain energy density factor * generalized linear elastic fracture mechanics * fracture criteria Subject RIV: JL - Materials Fatigue, Friction Mechanics

  16. Experiment HFIR-MFE-T3 for low-temperature irradiation of miniaturized Charpy V-notch specimens of nickel-doped ferritic steels

    The HFIR-MFE-T3 experimental capsule is described. This experiment consists of miniature Charpy V-notch specimens of 12 Cr-1 MoVW and 12 Cr-1 MoVW-2 Ni alloys. The different levels of nickel will result in different helium levels generated during irradiation, and thus will allow for an evaluation of the effect of helium on impact properties. Irradiation of the capsule has started with projected fluence at midplane that will produce 10 dpa expected by January 1982

  17. Evaluation of fracture toughness in dental ceramics using indentation and SEVNB (Single Edge V-Notched Beam)-method; Avaliacao da tenacidade a fratura de ceramicas dentarias atraves do metodo de entalhe - SEVNB (Single Edge V-Notched Beam)

    Santos, L.A.; Santos, C.; Souza, R.C.; Ribeiro, S. [Universidade de Sao Paulo (DEMAR/EEL/USP), Lorena, SP (Brazil). Escola de Engenharia de Lorena. Dept. de Engenharia de Materiais. Polo Urbo-Industrial; Strecker, K. [Universidade Federal de Sao Joao del-Rei (DME/UFSJ), MG (Brazil). Dept. de Materiais Eletricos; Oberacker, R. [Karlsruhe Univ. (Germany)

    2009-07-01

    In this work, the fracture toughness of different ceramics based on Al{sub 2}O{sub 3} and ZrO{sub 2} were evaluated using, comparatively two methods, Vickers indentation and SEVNB (Single Edge V-Notched Beam) method. Al{sub 2}O{sub 3}, ZrO{sub 2}(3%Y{sub 2}O{sub 3}) micro-particled and ZrO{sub 2}(3%Y{sub 2}O{sub 3}) nanometric, ZrO{sub 2}-Al{sub 2}O{sub 3} and Al{sub 2}O{sub 3}-ZrO{sub 2} composites were sintered at different temperatures. Samples were characterized by relative density, X-ray diffraction, SEM, and mechanical evaluation by hardness, bending strength and fracture toughness obtained by ickers indentation and SEVNB-method. The results were presented comparing the densification and microstructural results. Furthermore, the advantages and limitations of each method were discussed. (author)

  18. Analysis of Charpy V-notch impact toughness of irradiated A533-B class 1 plate and four submerged-arc welds

    Studies of the effects of neutron irradiation on Charpy V-notch impact properties of steels have, in general, included a minimum number of tests for each combination of material and irradiation parameters. The present study attempts to apply statistical analyses with multiple testing at selected temperatures to assess the accuracy and reliability of results. Charpy V-notch impact test specimens were irradiated in the Bulk Shielding Reactor at Oak Ridge National Laboratory at 2880C to target neutron fluences of 2 X 1023 neutrons (n)/m2 (>1 MeV). The materials were ASTM A533-B Class 1 plate (HeavySection Steel Technology Plate 02) and four submerged-arc welds representing current nuclear pressure vessel fabrication practice. Both unirradiated and irradiated specimens were tested by two separate groups and multiple tests were conducted at several selected temperatures. Statistical analyses permitted determination of material and test variability and an interlaboratory comparison. Several Charpy curve-fitting methods were used and results are compared with predictions from several ''trend curve'' expressions

  19. Plane elasto-plastic analysis of v-notched plate under bending by boundary integral equation method. Ph.D. Thesis

    Rzasnicki, W.

    1973-01-01

    A method of solution is presented, which, when applied to the elasto-plastic analysis of plates having a v-notch on one edge and subjected to pure bending, will produce stress and strain fields in much greater detail than presently available. Application of the boundary integral equation method results in two coupled Fredholm-type integral equations, subject to prescribed boundary conditions. These equations are replaced by a system of simultaneous algebraic equations and solved by a successive approximation method employing Prandtl-Reuss incremental plasticity relations. The method is first applied to number of elasto-static problems and the results compared with available solutions. Good agreement is obtained in all cases. The elasto-plastic analysis provides detailed stress and strain distributions for several cases of plates with various notch angles and notch depths. A strain hardening material is assumed and both plane strain and plane stress conditions are considered.

  20. On impact testing of subsize Charpy V-notch type specimens

    The potential for using subsize specimens to determine the actual properties of reactor pressure vessel steels is receiving increasing attention for improved vessel condition monitoring that could be beneficial for light-water reactor plant-life extension. This potential is made conditional upon, on the one hand, by the possibility of cutting samples of small volume from the internal surface of the pressure vessel for determination of actual properties of the operating pressure vessel. The plant-life extension will require supplemental surveillance data that cannot be provided by the existing surveillance programs. Testing of subsize specimens manufactured from broken halves of previously tested surveillance Charpy V-notch (CVN) specimens offers an attractive means of extending existing surveillance programs. Using subsize CVN type specimens requires the establishment of a specimen geometry that is adequate to obtain a ductile-to-brittle transition curve similar to that obtained from full-size specimens. This requires the development of a correlation of transition temperature and upper-shelf toughness between subsize and full-size specimens. The present study was conducted under the Heavy-Section Steel Irradiation Program. Different published approaches to the use of subsize specimens were analyzed and five different geometries of subsize specimens were selected for testing and evaluation. The specimens were made from several types of pressure vessel steels with a wide range of yield strengths, transition temperatures, and upper-shelf energies (USEs). Effects of specimen dimensions, including depth, angle, and radius of notch have been studied. The correlation of transition temperature determined from different types of subsize specimens and the full-size specimen is presented. A new procedure for transforming data from subsize specimens was developed and is presented

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    ... HERE New Drug Shows Mixed Results Against Early Alzheimer’s A new drug designed to treat Alzheimer’s disease ... Finder See All articles W e can end Alzheimer's Support the pioneering research of Nobel Laureate Dr. ...

  2. Showing similarity of results given by two methods: A commentary

    There is a frequent need in the environmental sciences to show the similarity of the results given by two analytical methods. This cannot, however, be done within the conventional 'there is a difference' statistical hypothesis setting of, among others, Student's t-test. We demonstrate here a more appropriate approach that originates from drug testing and that can be applied with standard statistical software. It is a challenging approach, as it requires quantification of the similarity limit. If no pre-determined value is given for similarity, a potential data-supported similarity limit can be explored from the data. The approach has numerous other potential application areas, e.g. parallelism of regression slopes, homogeneity of variances and lack of interaction. - Showing similarity of two methods calls for specific, yet simple, statistical techniques

  3. Degradation of mechanical properties of cast Cr-Mo-V and Cr-W-V steam turbine casings after long-term service at elevated temperatures: Pt. 2:; Fracture toughness, correlation of fracture toughness with Charpy V-notch toughness

    Holzmann, M.; Man, J.; Vlach, B. (Ceskoslovenska Akademie Ved, Brno (Czech Republic). Ustav Fyzikalni Metalurgie); Krumpos, J. (Czechoslovak Academy of Sciences, Plzen (Czech Republic). Inst. of Technology and Reliability of Machine Structures)

    1994-01-01

    The effect of long-term exposure at elevated temperatures on the transition behaviour of the fracture toughness temperature curve of cast Cr-Mo-V and Cr-W-V steels has been studied. The fracture toughness versus temperature behaviour after any operational period seems to be controlled by the initial fracture properties. Relationships linking the fracture toughness to Charpy V-notch impact properties are reported. The validity of these relationships for cast steels was confirmed. (Author)

  4. Dynamic Toughness Testing of Pre-Cracked Charpy V-Notch Specimens. Convention ELECTRABEL - SCK-CEN

    This document describes the experimental and analytical procedures which have been adopted at the laboratories of the Belgian Nuclear Research Centre SCK-CEN for performing dynamic toughness tests on pre-cracked Charpy-V specimens. Such procedures were chosen on the basis of the existing literature on the subject, with several updates in the data analysis stages which reflect more recent developments in fracture toughness testing. Qualification tests have been carried out on PCCv specimens of JRQ steel, in order to assess the reliability of the results obtained; straightforward comparisons with reference data have been performed, as well as more advanced analyses using the Master Curve approach. Aspects related to machine compliance and dynamic tup calibration have also been addressed

  5. Dynamic Toughness Testing of Pre-Cracked Charpy V-Notch Specimens. Convention ELECTRABEL - SCK-CEN

    Lucon, E

    1999-04-01

    This document describes the experimental and analytical procedures which have been adopted at the laboratories of the Belgian Nuclear Research Centre SCK-CEN for performing dynamic toughness tests on pre-cracked Charpy-V specimens. Such procedures were chosen on the basis of the existing literature on the subject, with several updates in the data analysis stages which reflect more recent developments in fracture toughness testing. Qualification tests have been carried out on PCCv specimens of JRQ steel, in order to assess the reliability of the results obtained; straightforward comparisons with reference data have been performed, as well as more advanced analyses using the Master Curve approach. Aspects related to machine compliance and dynamic tup calibration have also been addressed.

  6. Show What You Know: Musings on the Reporting of Negative Results in Speech Recognition Research

    Hermansky, Hynek; Morgan, Nelson

    2003-01-01

    {What is a Negative Result?} In a sense, well-designed experiments never have a completely negative result, since there is always the opportunity to learn something. In fact, unexpected results by definition provide the most information. Conventionally, negative results refer to those that do not support the hypothesis that an experiment has been designed to test; that is, results that are unable to disprove the null hypothesis (e.g., that the distinction between results from novel and baseli...

  7. Long-Term Trial Results Show No Mortality Benefit from Annual Prostate Cancer Screening

    Thirteen year follow-up data from the Prostate, Lung, Colorectal and Ovarian (PLCO) cancer screening trial show higher incidence but similar mortality among men screened annually with the prostate-specific antigen (PSA) test and digital rectal examination

  8. LOFT results show how international co-operation brings imaginative and cost-effective solutions

    There is a growing demand for nuclear experimental facilities to resemble more closely real reactors with regard to scale and test conditions - a requirement which results in greater complexity and, in particular, greater costs. The success of the OECD's Loss of Fluid Test facility (LOFT) project has shown that international co-operation is the way forward for safety research. LOFT was a small nuclear reactor designed to model a large four-loop PWR retaining the same volume/power ratio on a 1:50 volume scale. (author)

  9. AREVA: Operating performance shows distinct improvement; Results heavily impacted by the cost of remedial measures

    The 2015 results illustrate the progress AREVA made in 2015 and open up favorable prospects for 2016 and the following years in view of its fundamentals. The group's competitiveness plan had a very positive impact on its costs and cash, despite the heavy net loss situation which continues and in a market environment that remained difficult in 2015. Half of this loss of 2 billion Euro is due to additional provisions for OL3 and half to provisions for restructuring and impairment related to market conditions. Concerning the group's liquidity, 2016 is funded and the capital increase which will be launched in the coming months will enable AREVA to gradually regain the group's positive profile. A new phase awaits the Group in 2016 with clarity and confidence in the implementation of the restructuring announced in 2015 and in particular the autonomy of AREVA NP and the creation of New AREVA

  10. FES Training in Aging: interim results show statistically significant improvements in mobility and muscle fiber size

    Helmut Kern

    2012-03-01

    Full Text Available Aging is a multifactorial process that is characterized by decline in muscle mass and performance. Several factors, including reduced exercise, poor nutrition and modified hormonal metabolism, are responsible for changes in the rates of protein synthesis and degradation that drive skeletal muscle mass reduction with a consequent decline of force generation and mobility functional performances. Seniors with normal life style were enrolled: two groups in Vienna (n=32 and two groups in Bratislava: (n=19. All subjects were healthy and declared not to have any specific physical/disease problems. The two Vienna groups of seniors exercised for 10 weeks with two different types of training (leg press at the hospital or home-based functional electrical stimulation, h-b FES. Demografic data (age, height and weight were recorded before and after the training period and before and after the training period the patients were submitted to mobility functional analyses and muscle biopsies. The mobility functional analyses were: 1. gait speed (10m test fastest speed, in m/s; 2. time which the subject needed to rise from a chair for five times (5x Chair-Rise, in s; 3. Timed Up-Go- Test, in s; 4. Stair-Test, in s; 5. isometric measurement of quadriceps force (Torque/kg, in Nm/kg; and 6. Dynamic Balance in mm. Preliminary analyses of muscle biopsies from quadriceps in some of the Vienna and Bratislava patients present morphometric results consistent with their functional behaviors. The statistically significant improvements in functional testings here reported demonstrates the effectiveness of h-b FES, and strongly support h-b FES, as a safe home-based method to improve contractility and performances of ageing muscles.

  11. An Investigation on the Wear Resistance and Fatigue Behaviour of Ti-6Al-4V Notched Members Coated with Hydroxyapatite Coatings

    Reza H Oskouei

    2016-02-01

    Full Text Available In this study, surface properties of Ti-6Al-4V alloy coated with hydroxyapatite coatings were investigated. Wear resistance and fatigue behaviour of samples with coating thicknesses of 10 and 50 µm as well as uncoated samples were examined. Wear experiments demonstrated that the friction factor of the uncoated titanium decreased from 0.31 to 0.06, through a fluctuating trend, after 50 cycles of wear tests. However, the friction factor of both the coated samples (10 and 50 µm gradually decreased from 0.20 to 0.12 after 50 cycles. At the end of the 50th cycle, the penetration depth of the 10 and 50 µm coated samples were 7.69 and 6.06 µm, respectively. Fatigue tests showed that hydroxyapatite coatings could improve fatigue life of a notched Ti-6Al-4V member in both low and high cycle fatigue zones. It was understood, from fractography of the fracture surfaces, that the fatigue zone of the uncoated specimens was generally smaller in comparison with that of the coated specimens. No significant difference was observed between the fatigue life of coated specimens with 10 and 50 µm thicknesses.

  12. Numerical modelling of Charpy-V notch test by local approach to fracture. Application to an A508 steel in the ductile-brittle transition range

    Ferritic steels present a transition of the rupture mode which goes progressively of a brittle rupture (cleavage) to a ductile rupture when the temperature increases. The following of the difference of the transition temperature of the PWR vessel steel by the establishment of toughness curves makes of the Charpy test an integrating part of the monitoring of the French PWR reactors. In spite of the advantages which are adapted to it in particular its cost, the Charpy test does not allow to obtain directly a variable which characterizes a crack propagation resistance as for instance the toughness used for qualifying the mechanical integrity of a structure. This work deals with the establishment of the through impact strength-toughness in the transition range of the vessel steel: 16MND5 from a non-empirical approach based on the local approach of the rupture. The brittle rupture is described by the Beremin model (1983), which allows to describe the dispersion inherent in this rupture mode. The description of the brittle fissure is carried out by the GTN model (1984) and by the Rousselier model (1986). This last model has been modified in order to obtain a realistic description of the brittle damage in the case of fast solicitations and of local heating. The method proposed to determine the parameters of the damage models depends only of tests on notched specimens and of the inclusion data of the material. The behaviour is described by an original formulation parametrized in temperature which allows to describe all the tests carried out in this study. Before using this methodology, an experimental study of the behaviour and of the rupture modes of the steel 16MND5 has been carried out. From the toughness tests carried out in quasi-static and dynamical conditions, it has been revealed that this steel does not present important unwedging of its toughness curve due to the velocity effect. In the transition range, local heating of about 150 C have been measured in the root of the notch as well as plastic deformations superior to 100%. After a fractography study allowing to identify the nature of the sites which lead to the cleavage initiation, the numerical study shows, particularly, the effect of the adiabatic heating and the taking into account of the growth of cavities around a second population of particles (carbides) on the ductile fissure. The application of the proposed methodology allows to describe the resilience data until middle energies of about 70 J. Beyond, an appearing weak dependency of the cleavage constraint with temperature has to be introduced. On the other hand, the evolving of the toughness can be described until middle values of 170 MPa/m without introducing dependency of the cleavage constraint with temperature. (O.M.)

  13. Reception of Talent Shows in Denmark: First Results from a Trans-National Audience Study of a Global Format Genre

    Jensen, Pia Majbritt

    format adaptation, the musical talent show genre has been particularly successful in crossing cultural borders. Formats such as Idols, X Factor and Voice have sold to a large variety of countries, covering all continents. Such global reach inevitably raises the question of the genre’s audience appeal; to...... what degree its reach has to do with a universal appeal inherent in the genre and/or the innovative character of individual formats, and to what degree its global success is due to local broadcasters’ ability to successfully adapt the formats to local audience tastes. A consensus has developed that....... However, we also take into account that the national perspective needs to be considered critically. First, there are other factors but national culture that determine a local adaptation such as subnational target groups, channel identity, financing or chance incidents. Secondly, it has rightly been argued...

  14. Presentation Showing Results of a Hydrogeochemical Investigation of the Standard Mine Vicinity, Upper Elk Creek Basin, Colorado

    Manning, Andrew H.; Verplanck, Philip L.; Mast, M. Alisa; Wanty, Richard B.

    2008-01-01

    PREFACE This Open-File Report consists of a presentation given in Crested Butte, Colorado on December 13, 2007 to the Standard Mine Advisory Group. The presentation was paired with another presentation given by the Colorado Division of Reclamation, Mining, and Safety on the physical features and geology of the Standard Mine. The presentation in this Open-File Report summarizes the results and conclusions of a hydrogeochemical investigation of the Standard Mine performed by the U.S. Geological Survey (Manning and others, in press). The purpose of the investigation was to aid the U.S. Environmental Protection Agency in evaluating remediation options for the Standard Mine site. Additional details and supporting data related to the information in this presentation can be found in Manning and others (in press).

  15. Selection Indices and Multivariate Analysis Show Similar Results in the Evaluation of Growth and Carcass Traits in Beef Cattle.

    Brito Lopes, Fernando; da Silva, Marcelo Corrêa; Magnabosco, Cláudio Ulhôa; Goncalves Narciso, Marcelo; Sainz, Roberto Daniel

    2016-01-01

    This research evaluated a multivariate approach as an alternative tool for the purpose of selection regarding expected progeny differences (EPDs). Data were fitted using a multi-trait model and consisted of growth traits (birth weight and weights at 120, 210, 365 and 450 days of age) and carcass traits (longissimus muscle area (LMA), back-fat thickness (BF), and rump fat thickness (RF)), registered over 21 years in extensive breeding systems of Polled Nellore cattle in Brazil. Multivariate analyses were performed using standardized (zero mean and unit variance) EPDs. The k mean method revealed that the best fit of data occurred using three clusters (k = 3) (P decision making. Estimates of correlation between selection indices and the multivariate index (LD1) were moderate to high, ranging from 0.48 to 0.97. This reveals that both types of indices give similar results and that the multivariate approach is reliable for the purpose of selection. The alternative tool seems very handy when economic weights are not available or in cases where more rapid identification of the best animals is desired. Interestingly, multivariate analysis allowed forecasting information based on the relationships among breeding values (EPDs). Also, it enabled fine discrimination, rapid data summarization after genetic evaluation, and permitted accounting for maternal ability and the genetic direct potential of the animals. In addition, we recommend the use of longissimus muscle area and subcutaneous fat thickness as selection criteria, to allow estimation of breeding values before the first mating season in order to accelerate the response to individual selection. PMID:26789008

  16. Reanalysis of mGWAS results and in vitro validation show that lactate dehydrogenase interacts with branched-chain amino acid metabolism.

    Heemskerk, Mattijs M; van Harmelen, Vanessa Ja; van Dijk, Ko Willems; van Klinken, Jan Bert

    2016-01-01

    The assignment of causative genes to noncoding variants identified in genome-wide association studies (GWASs) is challenging. We show how combination of knowledge from gene and pathway databases and chromatin interaction data leads to reinterpretation of published quantitative trait loci for blood metabolites. We describe a previously unidentified link between the rs2403254 locus, which is associated with the ratio of 3-methyl-2-oxobutanoate and alpha-hydroxyisovalerate levels, and the distal LDHA gene. We confirmed that lactate dehydrogenase can catalyze the conversion between these metabolites in vitro, suggesting that it has a role in branched-chain amino acid metabolism. Examining datasets from the ENCODE project we found evidence that the locus and LDHA promoter physically interact, showing that LDHA expression is likely under control of distal regulatory elements. Importantly, this discovery demonstrates that bioinformatic workflows for data integration can have a vital role in the interpretation of GWAS results. PMID:26014429

  17. Analysis of conservative tracer measurement results using the Frechet distribution at planted horizontal subsurface flow constructed wetlands filled with coarse gravel and showing the effect of clogging processes.

    Dittrich, Ern?; Klincsik, Mihly

    2015-11-01

    A mathematical process, developed in Maple environment, has been successful in decreasing the error of measurement results and in the precise calculation of the moments of corrected tracer functions. It was proved that with this process, the measured tracer results of horizontal subsurface flow constructed wetlands filled with coarse gravel (HSFCW-C) can be fitted more accurately than with the conventionally used distribution functions (Gaussian, Lognormal, Fick (Inverse Gaussian) and Gamma). This statement is true only for the planted HSFCW-Cs. The analysis of unplanted HSFCW-Cs needs more research. The result of the analysis shows that the conventional solutions (completely stirred series tank reactor (CSTR) model and convection-dispersion transport (CDT) model) cannot describe these types of transport processes with sufficient accuracy. These outcomes can help in developing better process descriptions of very difficult transport processes in HSFCW-Cs. Furthermore, a new mathematical process can be developed for the calculation of real hydraulic residence time (HRT) and dispersion coefficient values. The presented method can be generalized to other kinds of hydraulic environments. PMID:26126688

  18. T-cell lines from 2 patients with adenosine deaminase (ADA) deficiency showed the restoration of ADA activity resulted from the reversion of an inherited mutation.

    Ariga, T; Oda, N; Yamaguchi, K; Kawamura, N; Kikuta, H; Taniuchi, S; Kobayashi, Y; Terada, K; Ikeda, H; Hershfield, M S; Kobayashi, K; Sakiyama, Y

    2001-05-01

    Inherited deficiency of adenosine deaminase (ADA) results in one of the autosomal recessive forms of severe combined immunodeficiency. This report discusses 2 patients with ADA deficiency from different families, in whom a possible reverse mutation had occurred. The novel mutations were identified in the ADA gene from the patients, and both their parents were revealed to be carriers. Unexpectedly, established patient T-cell lines, not B-cell lines, showed half-normal levels of ADA enzyme activity. Reevaluation of the mutations in these T-cell lines indicated that one of the inherited ADA gene mutations was reverted in both patients. At least one of the patients seemed to possess the revertant cells in vivo; however, the mutant cells might have overcome the revertant after receiving ADA enzyme replacement therapy. These findings may have significant implications regarding the prospects for stem cell gene therapy for ADA deficiency. PMID:11313286

  19. Transgene silencing of the Hutchinson-Gilford progeria syndrome mutation results in a reversible bone phenotype, whereas resveratrol treatment does not show overall beneficial effects.

    Strandgren, Charlotte; Nasser, Hasina Abdul; McKenna, Tomás; Koskela, Antti; Tuukkanen, Juha; Ohlsson, Claes; Rozell, Björn; Eriksson, Maria

    2015-08-01

    Hutchinson-Gilford progeria syndrome (HGPS) is a rare premature aging disorder that is most commonly caused by a de novo point mutation in exon 11 of the LMNA gene, c.1824C>T, which results in an increased production of a truncated form of lamin A known as progerin. In this study, we used a mouse model to study the possibility of recovering from HGPS bone disease upon silencing of the HGPS mutation, and the potential benefits from treatment with resveratrol. We show that complete silencing of the transgenic expression of progerin normalized bone morphology and mineralization already after 7 weeks. The improvements included lower frequencies of rib fractures and callus formation, an increased number of osteocytes in remodeled bone, and normalized dentinogenesis. The beneficial effects from resveratrol treatment were less significant and to a large extent similar to mice treated with sucrose alone. However, the reversal of the dental phenotype of overgrown and laterally displaced lower incisors in HGPS mice could be attributed to resveratrol. Our results indicate that the HGPS bone defects were reversible upon suppressed transgenic expression and suggest that treatments targeting aberrant progerin splicing give hope to patients who are affected by HGPS. PMID:25877214

  20. Transgene silencing of the Hutchinson-Gilford progeria syndrome mutation results in a reversible bone phenotype, whereas resveratrol treatment does not show overall beneficial effects

    Strandgren, Charlotte; Nasser, Hasina Abdul; McKenna, Tomás; Koskela, Antti; Tuukkanen, Juha; Ohlsson, Claes; Rozell, Björn; Eriksson, Maria

    2015-01-01

    progerin splicing give hope to patients who are affected by HGPS.-Strandgren, C., Nasser, H. A., McKenna, T., Koskela, A., Tuukkanen, J., Ohlsson, C., Rozell, B., Eriksson, M. Transgene silencing of the Hutchinson-Gilford progeria syndrome mutation results in a reversible bone phenotype, whereas...

  1. Genetic susceptibility to childhood acute lymphoblastic leukemia shows protection in Malay boys: results from the Malaysia-Singapore ALL Study Group.

    Yeoh, Allen Eng-Juh; Lu, Yi; Chan, Jason Yong-Sheng; Chan, Yiong Huak; Ariffin, Hany; Kham, Shirley Kow-Yin; Quah, Thuan Chong

    2010-03-01

    To study genetic epidemiology of childhood acute lymphoblastic leukemia (ALL) in the Chinese and Malays, we investigated 10 polymorphisms encoding carcinogen- or folate-metabolism and transport. Sex-adjusted analysis showed NQO1 609CT significantly protects against ALL, whilst MTHFR 677CT confers marginal protection. Interestingly, we observed that NQO1 609CT and MTHFR 1298 C-allele have greater genetic impact in boys than in girls. The combination of SLC19A1 80GA heterozygosity and 3'-TYMS -6bp/-6bp homozygous deletion is associated with reduced ALL risk in Malay boys. Our study has suggested the importance of gender and race in modulating ALL susceptibility via the folate metabolic pathway. PMID:19651439

  2. Mathematical modelling in Matlab of the experimental results shows the electrochemical potential difference - temperature of the WC coatings immersed in a NaCl solution

    Benea, M. L.; Benea, O. D.

    2016-02-01

    The method used for purchasing the corrosion behaviour the WC coatings deposited by plasma spraying, on a martensitic stainless steel substrate consists in measuring the electrochemical potential of the coating, respectively that of the substrate, immersed in a NaCl solution as corrosive agent. The mathematical processing of the obtained experimental results in Matlab allowed us to make some correlations between the electrochemical potential of the coating and the solution temperature is very well described by some curves having equations obtained by interpolation order 4.

  3. The Use of Online Pre-Lab Assessments Compared with Written Pre-Lab Assignments Requiring Experimental Result Prediction Shows No Difference in Student Performance

    Erica L. Suchman

    2015-08-01

    Full Text Available Exam performance was compared for students who hand wrote questions designed to prepare them for daily lab activities in a senior level virology laboratory course versus those who answered questions created to mirror the written questions on-line. No significant difference was noted in exam scores on any of the three midterms, written final exam, nor the practical exam. Neither was there a significant difference in the quality of the laboratory reports turned in as evidenced by similar average scores over four years. These results indicate that using online pre-labs to prepare students for the laboratory sessions leads to equivalent learning as answering handwritten pre-lab assignments. Online pre-labs significantly reduced the amount of grading without reducing student learning, allowing a reduction in the number of teaching assistants required per section.

  4. Violence and TV Shows

    ZTRK, Yrd. Do. Dr. ?inasi

    2008-01-01

    This study aims to discuss theories on theviolent effects of TV shows on viewers, especiallyon children. Therefore, this study includes a briefdiscussion of definitions of violence, discussionof violence theories, main results of researcheson televised violence, measuring TV violence,perception of televised violence, individualdifferences and reactions to TV violence,aggressiveness and preferences for TV violence.

  5. Television Quiz Show Simulation

    Hill, Jonnie Lynn

    2007-01-01

    This article explores the simulation of four television quiz shows for students in China studying English as a foreign language (EFL). It discusses the adaptation and implementation of television quiz shows and how the students reacted to them.

  6. Show-Bix &

    2014-01-01

    The anti-reenactment 'Show-Bix &' consists of 5 dias projectors, a dial phone, quintophonic sound, and interactive elements. A responsive interface will enable the Dias projectors to show copies of original dias slides from the Show-Bix piece ”March på Stedet”, 265 images in total. The copies are...

  7. Showing Value (Editorial

    Denise Koufogiannakis

    2009-06-01

    Full Text Available When Su Cleyle and I first decided to start Evidence Based Library and Information Practice, one of the things we agreed upon immediately was that the journal be open access. We knew that a major obstacle to librarians using the research literature was that they did not have access to the research literature. Although Su and I are both academic librarians who can access a wide variety of library and information literature from our institutions, we belong to a profession where not everyone has equal access to the research in our field. Without such access to our own body of literature, how can we ever hope for practitioners to use research evidence in their decision making? It would have been contradictory to the principles of evidence based library and information practice to do otherwise.One of the specific groups we thought could use such an open access venue for discovering research literature was school librarians. School librarians are often isolated and lacking access to the research literature that may help them prove to stakeholders the importance of their libraries and their role within schools. Certainly, school libraries have been in decline and the use of evidence to show value is needed. As Ken Haycock noted in his 2003 report, The Crisis in Canada’s School Libraries: The Case for Reform and Reinvestment, “Across the country, teacher-librarians are losing their jobs or being reassigned. Collections are becoming depleted owing to budget cuts. Some principals believe that in the age of the Internet and the classroom workstation, the school library is an artifact” (9. Within this context, school librarians are looking to our research literature for evidence of the impact that school library programs have on learning outcomes and student success. They are integrating that evidence into their practice, and reflecting upon what can be improved locally. They are focusing on students and showing the impact of school libraries and librarians on student achievement. Todd notes, “If we do not show value, we will not have a future. Evidence-based practice is not about the survival of school librarians, it’s about the survival of our students” (40. In this issue we feature school libraries and their connection to evidence based practice. Former Editor-in-Chief, Lindsay Glynn, began putting the wheels in motion for this feature almost a year ago. She invited Carol Gordon and Ross Todd to act as guest editors of the section, drawing upon their contacts and previous work in this field. The result is an issue with five feature articles exploring different aspects of the connection between school libraries and evidence based practice, from the theoretical to the practical. In addition, there is a thought-provoking Commentary by David Loertscher, asking whether we need the evolutionary model of evidence based practice, or something more revolutionary!In addition to the Feature section, we have a well-rounded issue with articles on the topics of library human resources, and the development of a scholars’ portal. As well, there are a record 10 evidence summaries and our educational EBL101 column. I hope there is something for everyone in this issue of EBLIP – enjoy, and see you soon in Stockholm!

  8. Talking with TV shows

    Sandvik, Kjetil; Laursen, Ditte

    2014-01-01

    User interaction with radio and television programmes is not a new thing. However, with new cross-media production concepts such as X Factor and Voice, this is changing dramatically. The second-screen logic of these productions encourages viewers, along with TV’s traditional one-way communication...... mode, to communicate on interactive (dialogue-enabling) devices such as laptops, smartphones and tablets. Using the TV show Voice as our example, this article shows how the technological and situational set-up of the production invites viewers to engage in new ways of interaction and communication...

  9. Comparison of results of different methods for the analysis of flux creep behavior in a melt-textured YBa2Cu3O7-x sample showing a fishtail effect

    Magnetic investigations of the flux creep behavior of a melt-textured YBa2Cu3O7-x sample with a pronounced fishtail effect are reported. To get information about the influence of oxygen on the pinning behavior, the sample was measured before and after a change in oxygen content by annealing. From the time dependence of the magnetic moment measured at fields of 1, 3, and 5 T and at temperatures between 4 and 72 K, the current density dependence of the effective activation energy was determined and interpreted in terms of collective pinning theory. The results are compared with those obtained from the simpler analysis within Anderson's flux creep theory, as well as with the results of an analysis in terms of activation energy distributions. Finally, measurements of the hysteresis loops recorded with different field sweep rates were analyzed using the generalized inversion scheme. The nature of the fishtail is discussed in comparison with existing models, which try to explain this effect. From all these analyses, a phase diagram for the pinning in the investigated sample is proposed, which is based on the assumption that two different types of pinning centers exist, which behave in different ways. Those that dominate in the field and temperature regime where no fishtail appears may be denoted as background pinning centers. They show a three-dimensional behavior with a change from small-flux-bundle pinning to large-flux-bundle pinning at higher temperatures. The pinning behavior in this field and temperature regime is not influenced by a change in the oxygen content. In contrast, the pinning centers that dominate in the field and temperature regime where the fishtail appears have higher activation energies and show a two-dimensional pinning behavior with a change from single vortex creep to collective vortex creep with increasing field and temperature. These pinning centers are strongly influenced by the oxygen content. (Abstract Truncated)

  10. Comparison of results of different methods for the analysis of flux creep behavior in a melt-textured YBa{sub 2}Cu{sub 3}O{sub 7{minus}x} sample showing a fishtail effect

    Reissner, M.; Lorenz, J. [Institute of Applied and Technical Physics, Technical University of Vienna, A-1040 Vienna (Austria)

    1997-09-01

    Magnetic investigations of the flux creep behavior of a melt-textured YBa{sub 2}Cu{sub 3}O{sub 7{minus}x} sample with a pronounced fishtail effect are reported. To get information about the influence of oxygen on the pinning behavior, the sample was measured before and after a change in oxygen content by annealing. From the time dependence of the magnetic moment measured at fields of 1, 3, and 5 T and at temperatures between 4 and 72 K, the current density dependence of the effective activation energy was determined and interpreted in terms of collective pinning theory. The results are compared with those obtained from the simpler analysis within Anderson`s flux creep theory, as well as with the results of an analysis in terms of activation energy distributions. Finally, measurements of the hysteresis loops recorded with different field sweep rates were analyzed using the generalized inversion scheme. The nature of the fishtail is discussed in comparison with existing models, which try to explain this effect. From all these analyses, a phase diagram for the pinning in the investigated sample is proposed, which is based on the assumption that two different types of pinning centers exist, which behave in different ways. Those that dominate in the field and temperature regime where no fishtail appears may be denoted as background pinning centers. They show a three-dimensional behavior with a change from small-flux-bundle pinning to large-flux-bundle pinning at higher temperatures. The pinning behavior in this field and temperature regime is not influenced by a change in the oxygen content. In contrast, the pinning centers that dominate in the field and temperature regime where the fishtail appears have higher activation energies and show a two-dimensional pinning behavior with a change from single vortex creep to collective vortex creep with increasing field and temperature. These pinning centers are strongly influenced by the oxygen content. (Abstract Truncated)

  11. Obesity in show dogs.

    Corbee, R J

    2012-08-11

    Obesity is an important disease with a growing incidence. Because obesity is related to several other diseases, and decreases life span, it is important to identify the population at risk. Several risk factors for obesity have been described in the literature. A higher incidence of obesity in certain breeds is often suggested. The aim of this study was to determine whether obesity occurs more often in certain breeds. The second aim was to relate the increased prevalence of obesity in certain breeds to the official standards of that breed. To this end, we investigated 1379 dogs of 128 different breeds by determining their body condition score (BCS). Overall, 18.6% of the show dogs had a BCS >5, and 1.1% of the show dogs had a BCS>7. There were significant differences between breeds, which could be correlated to the breed standards. It warrants firm discussions with breeders and judges in order to come to different interpretations of the standards to prevent overweight conditions from being the standard of beauty. PMID:22882163

  12. Dietary fiber showed no preventive effect against colon and rectal cancers in Japanese with low fat intake: an analysis from the results of nutrition surveys from 23 Japanese prefectures

    Sugawara Kazuo

    2001-10-01

    Full Text Available Abstract Background Since Fuchs' report in 1999, the reported protective effect of dietary fiber from colorectal carcinogenesis has led many researchers to question its real benefit. The aim of this study is to evaluate the association between diet, especially dietary fiber and fat and colorectal cancer in Japan. Methods A multiple regression analysis (using the stepwise variable selection method was performed using the standardized mortality ratios (SMRs of colon and rectal cancer in 23 Japanese prefectures as objective variables and dietary fiber, nutrients and food groups as explanatory variables. Results As for colon cancer, the standardized partial correlation coefficients were positively significant for fat (1,13, P = 0.000, seaweeds (0.41, P = 0.026 and beans (0.45, P = 0.017 and were negatively significant for vitamin A (-0.63, P = 0.003, vitamin C (-0.42, P = 0.019 and yellow-green vegetables (-0.37, P = 0.046. For rectal cancer, the standardized partial correlation coefficient in fat (0.60, P = 0.002 was positively significant. Dietary fiber was not found to have a significant relationship with either colon or rectal cancers. Conclusions This study failed to show any protective effect of dietary fiber in subjects with a low fat intake (Japanese in this analysis, which supports Fuchs' findings in subjects with a high fat intake (US Americans.

  13. Results of crack-arrest tests on irradiated a 508 class 3 steel

    Iskander, S.K.; Milella, P.P.; Pini, M.A.

    1998-02-01

    Ten crack-arrest toughness values for irradiated specimens of A 508 class 3 forging steel have been obtained. The tests were performed according to the American Society for Testing and Materials (ASTM) Standard Test Method for Determining Plane-Strain Crack-Arrest Fracture Toughness, K{sub la} of Ferritic Steels, E 1221-88. None of these values are strictly valid in all five ASTM E 1221-88 validity criteria. However, they are useful when compared to unirradiated crack-arrest specimen toughness values since they show the small (averaging approximately 10{degrees}C) shifts in the mean and lower-bound crack-arrest toughness curves. This confirms that a low copper content in ASTM A 508 class 3 forging material can be expected to result in small shifts of the transition toughness curve. The shifts due to neutron irradiation of the lower bound and mean toughness curves are approximately the same as the Charpy V-notch (CVN) 41-J temperature shift. The nine crack-arrest specimens were irradiated at temperatures varying from 243 to 280{degrees}C, and to a fluence varying from 1.7 to 2.7 x 10{sup 19} neutrons/cm{sup 2} (> 1 MeV). The test results were normalized to reference values that correspond to those of CVN specimens irradiated at 284{degrees}C to a fluence of 3.2 x 10{sup 19} neutrons/cm{sup 2} (> 1 MeV) in the same capsule as the crack-arrest specimens. This adjustment resulted in a shift to lower temperatures of all the data, and in particular moved two data points that appeared to lie close to or lower than the American Society of Mechanical Engineers K{sub la} curve to positions that seemed more reasonable with respect to the remaining data. A special fixture was designed, fabricated, and successfully used in the testing. For reasons explained in the text, special blocks to receive the Oak Ridge National Laboratory clip gage were designed, and greater-than-standard crack-mouth opening displacements measured were accounted for. 24 refs., 13 figs., 12 tabs.

  14. Results of crack-arrest tests on irradiated a 508 class 3 steel

    Ten crack-arrest toughness values for irradiated specimens of A 508 class 3 forging steel have been obtained. The tests were performed according to the American Society for Testing and Materials (ASTM) Standard Test Method for Determining Plane-Strain Crack-Arrest Fracture Toughness, Kla of Ferritic Steels, E 1221-88. None of these values are strictly valid in all five ASTM E 1221-88 validity criteria. However, they are useful when compared to unirradiated crack-arrest specimen toughness values since they show the small (averaging approximately 10 degrees C) shifts in the mean and lower-bound crack-arrest toughness curves. This confirms that a low copper content in ASTM A 508 class 3 forging material can be expected to result in small shifts of the transition toughness curve. The shifts due to neutron irradiation of the lower bound and mean toughness curves are approximately the same as the Charpy V-notch (CVN) 41-J temperature shift. The nine crack-arrest specimens were irradiated at temperatures varying from 243 to 280 degrees C, and to a fluence varying from 1.7 to 2.7 x 1019 neutrons/cm2 (> 1 MeV). The test results were normalized to reference values that correspond to those of CVN specimens irradiated at 284 degrees C to a fluence of 3.2 x 1019 neutrons/cm2 (> 1 MeV) in the same capsule as the crack-arrest specimens. This adjustment resulted in a shift to lower temperatures of all the data, and in particular moved two data points that appeared to lie close to or lower than the American Society of Mechanical Engineers Kla curve to positions that seemed more reasonable with respect to the remaining data. A special fixture was designed, fabricated, and successfully used in the testing. For reasons explained in the text, special blocks to receive the Oak Ridge National Laboratory clip gage were designed, and greater-than-standard crack-mouth opening displacements measured were accounted for. 24 refs., 13 figs., 12 tabs

  15. Charpy impact test results on five materials and NIST verification specimens using instrumented 2-mm and 8-mm strikers

    Nanstad, R.K.; Sokolov, M.A.

    1995-04-01

    The Heavy-Section Steel Irradiation Program at Oak Ridge National Laboratory is involved in two cooperative projects, with international participants, both of which involve Charpy V-notch impact tests with instrumented strikers of 2mm and 8mm radii. Two heats of A 533 grade B class I pressure vessel steel and a low upper-shelf (LUS) submerged-arc (SA) weld were tested on the same Charpy machine, while one heat of a Russian Cr-Mo-V forging steel and a high upper-shelf (HUS) SA weld were tested on two different machines. The number of replicate tests at any one temperature ranged from 2 to 46 specimens. Prior to testing with each striker, verification specimens at the low, high, and super high energy levels from the National Institute of Standards and Technology (NIST) were tested. In the two series of verification tests, the tests with the 2mm striker met the requirements at the low and high energy levels but not at the super high energy. For one plate, the 2mm striker showed somewhat higher average absorbed energies than those for the 8-mm striker at all three test temperatures. For the second plate and the LUS weld, however, the 2mm striker showed somewhat lower energies at both test temperatures. For the Russian forging steel and the HUS weld, tests were conducted over a range of temperatures with tests at one laboratory using the 8mm striker and tests at a second laboratory using the 2mm striker. Lateral expansion was measured for all specimens and the results are compared with the absorbed energy results. The overall results showed generally good agreement (within one standard deviation) in energy measurements by the two strikers. Load-time traces from the instrumented strikers were also compared and used to estimate shear fracture percentage. Four different formulas from the European Structural Integrity Society draft standard for instrumented Charpy test are compared and a new formula is proposed for estimation of percent shear from the force-time trace.

  16. Tagging SNP haplotype analysis of the secretory PLA2-V gene, PLA2G5, shows strong association with LDL and oxLDL levels, suggesting functional distinction from sPLA2-IIA: results from the UDACS study.

    Wootton, Peter T E; Arora, Nupur L; Drenos, Fotios; Thompson, Simon R; Cooper, Jackie A; Stephens, Jeffrey W; Hurel, Steven J; Hurt-Camejo, Eva; Wiklund, Olov; Humphries, Steve E; Talmud, Philippa J

    2007-06-15

    Animal and human studies suggest that both secretory PLA2 (sPLA2)-V and sPLA2-IIA (encoded, respectively, by the neighbouring PLA2G5 and PLA2G2A genes) contribute to atherogenesis. Elevated plasma sPLA2-IIA predicts coronary heart disease (CHD) risk, but no mass assay for sPLA2-V is available. We previously reported that tagging single nucleotide polymorphism (tSNP) haplotypes of PLA2G2A are strongly associated with sPLA2-IIA mass, but not lipid levels. Here, we use tSNPs of the sPLA2-V gene to investigate the association of PLA2G5 with CHD risk markers. Seven PLA2G5 tSNPs genotypes, explaining >92% of the locus genetic variability, were determined in 519 patients with Type II diabetes (in whom PLA2G2A tSNP data was available), and defined seven common haplotypes (frequencies >5%). PLA2G5 and PLA2G2A tSNPs showed linkage disequilibrium (LD). Compared to the common PLA2G5 haplotype, H1 (frequency 34.9%), haplotypes H2-7 were associated with overall higher plasma LDL (P < 0.00004) and total cholesterol (P < 0.00003) levels yet lower oxLDL/LDL (P = 0.006) and sPLA2-IIA mass (P = 0.04), probably reflecting LD with PLA2G2A. Intronic tSNP (rs11573248), unlikely itself to be functional, distinguished H1 from LDL-raising haplotypes and may mark a functional site. In conclusion, PLA2G5 tSNP haplotypes demonstrate an association with total and LDL cholesterol and oxLDL/LDL, not seen with PLA2G2A, thus confirming distinct functional roles for these two sPLA2s. PMID:17545304

  17. The "Life Potential": a new complex algorithm to assess "Heart Rate Variability" from Holter records for cognitive and diagnostic aims. Preliminary experimental results showing its dependence on age, gender and health conditions

    Barra, Orazio A

    2013-01-01

    Although HRV (Heart Rate Variability) analyses have been carried out for several decades, several limiting factors still make these analyses useless from a clinical point of view. The present paper aims at overcoming some of these limits by introducing the "Life Potential" (BMP), a new mathematical algorithm which seems to exhibit surprising cognitive and predictive capabilities. BMP is defined as a linear combination of five HRV Non-Linear Variables, in turn derived from the thermodynamic formalism of chaotic dynamic systems. The paper presents experimental measurements of BMP (Average Values and Standard Deviations) derived from 1048 Holter tests, matched in age and gender, including a control group of 356 healthy subjects. The main results are: (a) BMP always decreases when the age increases, and its dependence on age and gender is well established; (b) the shape of the age dependence within "healthy people" is different from that found in the general group: this behavior provides evidence of possible illn...

  18. Applications of surveillance programme results to reactor pressure vessel integrity assessment. Results of a coordinated research project 2000-2004

    This TECDOC has been developed under an IAEA Coordinated Research Project (CRP) on Surveillance Programme Results Application to Reactor Pressure Vessel Integrity Assessment. This CRP is the fifth in a series that have led to the defining of the most appropriate fracture toughness parameters (using relatively small test specimens) for ensuring structural integrity of reactor pressure vessel (RPV) materials. The CRP group consisted of 20 testing laboratories representing 15 Member States. The CRP had three main objectives: (1) to develop a large database of fracture toughness data using the Master Curve methodology for both precracked Charpy-sized specimens and one-inch thick (25.4 mm) compact tension (1T-CT) specimens, (2) to assess possible specimen bias effects and any effects of the range of temperatures used to determine T0, either using the single temperature or multi-temperature assessment methods, and (3) to develop international guidelines for measuring and applying Master Curve fracture toughness results for RPV integrity assessment. Fracture toughness test results showed clear evidence that lower values of unirradiated T0 were obtained using precracked Charpy specimens compared with results obtained from 1T-CT specimens. This bias in test results is very important when considering the use of precracked Charpy specimens for evaluating RPV integrity. In fact, this is a technical area where the results from this CRP were influential in changing the ASTM test method to include consideration of this effect. The direct measurement approach using the Master Curve approach for RPV structural integrity assessment has distinct advantages over the indirect methods used in the past for assessing radiation embrittlement effects. The Master Curve methodology already has been or is being assimilated into the ASME Boiler and Pressure Vessel Code, ASTM Standards, USNRC Regulations, German Regulations (KTA 3203), IAEA pressurized thermal shock guidelines for WWER reactors as well as the unified procedure for WWER component lifetime assessment and other industry guidance documents governing RPV integrity analysis. This report was written to allow nuclear utility engineers and industry scientists to directly measure fracture toughness using small surveillance size specimens of irradiated reactor pressure vessel steels and directly apply the results using the Master Curve approach for RPV structural integrity assessment. This report provides a summary of Master Curve fracture toughness test results on small surveillance type specimens of the IAEA Reference Material JRQ and other national steels from numerous laboratories throughout the world. In addition to transition temperature testing using Charpy V-notch test specimens, some emphasis was placed on using tensile and early-design fracture toughness test specimens applying elastic-plastic fracture mechanics methods. Further progress in the application of fracture mechanics analysis methods for radiation damage assessment was achieved in this phase. Improvement and unification of neutron dosimetry methods provided better data with less inherent scatter. All results together with their analyses and raw data were summarized in IAEA Technical Reports Series No. 265

  19. Stem cells show promising results for lymphoedema treatment

    Toyserkani, Navid Mohamadpour; Quaade, Marlene Louise; Sheikh, Søren Paludan; Sørensen, Jens Ahm

    2015-01-01

    Abstract Lymphoedema is a debilitating condition, manifesting in excess lymphatic fluid and swelling of subcutaneous tissues. Lymphoedema is as of yet still an incurable condition and current treatment modalities are not satisfactory. The capacity of mesenchymal stem cells to promote angiogenesis......, secrete growth factors, regulate the inflammatory process, and differentiate into multiple cell types make them a potential ideal therapy for lymphoedema. Adipose tissue is the richest and most accessible source of mesenchymal stem cells and they can be harvested, isolated, and used for therapy in a...... single stage procedure as an autologous treatment. The aim of this paper was to review all studies using mesenchymal stem cells for lymphoedema treatment with a special focus on the potential use of adipose-derived stem cells. A systematic search was performed and five preclinical and two clinical...

  20. Numerical modelling of Charpy-V notch test by local approach to fracture. Application to an A508 steel in the ductile-brittle transition range; Modelisation de l'essai Charpy par l'approche locale de la rupture. Application au cas de l'acier 16MND5 dans le domaine de transition

    Tanguy, B

    2001-07-15

    Ferritic steels present a transition of the rupture mode which goes progressively of a brittle rupture (cleavage) to a ductile rupture when the temperature increases. The following of the difference of the transition temperature of the PWR vessel steel by the establishment of toughness curves makes of the Charpy test an integrating part of the monitoring of the French PWR reactors. In spite of the advantages which are adapted to it in particular its cost, the Charpy test does not allow to obtain directly a variable which characterizes a crack propagation resistance as for instance the toughness used for qualifying the mechanical integrity of a structure. This work deals with the establishment of the through impact strength-toughness in the transition range of the vessel steel: 16MND5 from a non-empirical approach based on the local approach of the rupture. The brittle rupture is described by the Beremin model (1983), which allows to describe the dispersion inherent in this rupture mode. The description of the brittle fissure is carried out by the GTN model (1984) and by the Rousselier model (1986). This last model has been modified in order to obtain a realistic description of the brittle damage in the case of fast solicitations and of local heating. The method proposed to determine the parameters of the damage models depends only of tests on notched specimens and of the inclusion data of the material. The behaviour is described by an original formulation parametrized in temperature which allows to describe all the tests carried out in this study. Before using this methodology, an experimental study of the behaviour and of the rupture modes of the steel 16MND5 has been carried out. From the toughness tests carried out in quasi-static and dynamical conditions, it has been revealed that this steel does not present important unwedging of its toughness curve due to the velocity effect. In the transition range, local heating of about 150 C have been measured in the root of the notch as well as plastic deformations superior to 100%. After a fractography study allowing to identify the nature of the sites which lead to the cleavage initiation, the numerical study shows, particularly, the effect of the adiabatic heating and the taking into account of the growth of cavities around a second population of particles (carbides) on the ductile fissure. The application of the proposed methodology allows to describe the resilience data until middle energies of about 70 J. Beyond, an appearing weak dependency of the cleavage constraint with temperature has to be introduced. On the other hand, the evolving of the toughness can be described until middle values of 170 MPa/m without introducing dependency of the cleavage constraint with temperature. (O.M.)

  1. Experimental evaluation of strain fields in the vicinity of V-notch in ductile metal

    Jandejsek, Ivan; Jiroušek, Ondřej; Vavřík, Daniel

    Praha : ČVUT, 2012 - (Plachý, P.; Padevět, P.; Tesárek, P.; Stránský, J.; Zobal, O.), s. 89-94 ISBN 978-80-01-05097-2. [Nano and Macro mechanics 2012 /3./. Praha (CZ), 20.09.2012] R&D Projects: GA ČR(CZ) GA103/09/2101 Institutional support: RVO:68378297 Keywords : strain/ stress measurement * digital image correlation * fracture mechanics Subject RIV: JL - Materials Fatigue, Friction Mechanics

  2. Study of the plastic zone shape and size in the V-notch tip vicinity

    Klusák, Jan

    Brno : Vysoké učení technické Brno, 2000, s. 11. [3re Workshop Weimar/Brno, reliability, revitalization, reengineering . Brno (CZ), 05.10.2000-06.10.2000] R&D Projects: GA AV ČR KSK1076602; GA AV ČR IBS2041001 Subject RIV: JL - Materials Fatigue, Friction Mechanics

  3. Planning a Successful Tech Show

    Nikirk, Martin

    2011-01-01

    Tech shows are a great way to introduce prospective students, parents, and local business and industry to a technology and engineering or career and technical education program. In addition to showcasing instructional programs, a tech show allows students to demonstrate their professionalism and skills, practice public presentations, and interact

  4. Hey Teacher, Your Personality's Showing!

    Paulsen, James R.

    1977-01-01

    A study of 30 fourth, fifth, and sixth grade teachers and 300 of their students showed that a teacher's age, sex, and years of experience did not relate to students' mathematics achievement, but that more effective teachers showed greater "freedom from defensive behavior" than did less effective teachers. (DT)

  5. Measuring performance at trade shows

    Hansen, Kåre

    2004-01-01

    captures a outcome-based sales dimension and four behavior-based dimensions (i.e. information-gathering, relationship building, image building, and motivation activities). A 16-item instrument is developed for assessing exhibitors perceptions of their trade show performance. The paper presents evidence of......Trade shows is an increasingly important marketing activity to many companies, but current measures of trade show performance do not adequately capture dimensions important to exhibitors. Based on the marketing literature's outcome and behavior-based control system taxonomy, a model is built that...... the scale's reliability, factor structure, and validity on the basis of analyzing data from independent samples of exhibitors at the international trade shows SIAL (Paris) and ANUGA (Cologne); and it concludes with a discussion of potential managerial applications and implications for future research...

  6. Tokyo Motor Show 2003; Tokyo Motor Show 2003

    Joly, E.

    2004-01-01

    The text which follows present the different techniques exposed during the 37. Tokyo Motor Show. The report points out the great tendencies of developments of the Japanese automobile industry. The hybrid electric-powered vehicles or those equipped with fuel cells have been highlighted by the Japanese manufacturers which allow considerable budgets in the research of less polluting vehicles. The exposed models, although being all different according to the manufacturer, use always a hybrid system: fuel cell/battery. The manufacturers have stressed too on the intelligent systems for navigation and safety as well as on the design and comfort. (O.M.)

  7. Risk Aversion in Game Shows

    Andersen, Steffen; Harrison, Glenn W.; Lau, Morten I.; Rutström, E. Elisabet

    , and the dynamic nature of the task in most games. We consider the game shows Card Sharks, Jeopardy!, Lingo, and finally Deal Or No Deal. We provide a detailed case study of the analyses of Deal Or No Deal, since it is suitable for inference about risk attitudes and has attracted considerable attention....

  8. Phoenix Scoop Inverted Showing Rasp

    2008-01-01

    This image taken by the Surface Stereo Imager on Sol 49, or the 49th Martian day of the mission (July 14, 2008), shows the silver colored rasp protruding from NASA's Phoenix Mars Lander's Robotic Arm scoop. The scoop is inverted and the rasp is pointing up. Shown with its forks pointing toward the ground is the thermal and electrical conductivity probe, at the lower right. The Robotic Arm Camera is pointed toward the ground. The Phoenix Mission is led by the University of Arizona, Tucson, on behalf of NASA. Project management of the mission is led by NASA's Jet Propulsion Laboratory, Pasadena, Calif. Spacecraft development is by Lockheed Martin Space Systems, Denver.

  9. Ostrich meat shows nutritional advantages

    Naseva, Dijana; Pejkovski, Zlatko; Kuzelov, Aco

    2013-01-01

    Having been faced with the fact that the mankind feeds less healthy and the number of people with cancer and cardiovascular diseases increases as a result of inappropriate diet, the nutritionists’ advice is to decrease the fat and cholesterol in the nutrition, and as for the meat, they suggest low fat meat rich in protein. The World Health Organization is the cheerleader in emphasizing the slogan “healthy food”. Taking into consideration the healthy meat alternatives, this paper determines th...

  10. Casimir experiments showing saturation effects

    We address several different Casimir experiments where theory and experiment disagree. First out is the classical Casimir force measurement between two metal half spaces; here both in the form of the torsion pendulum experiment by Lamoreaux and in the form of the Casimir pressure measurement between a gold sphere and a gold plate as performed by Decca et al.; theory predicts a large negative thermal correction, absent in the high precision experiments. The third experiment is the measurement of the Casimir force between a metal plate and a laser irradiated semiconductor membrane as performed by Chen et al.; the change in force with laser intensity is larger than predicted by theory. The fourth experiment is the measurement of the Casimir force between an atom and a wall in the form of the measurement by Obrecht et al. of the change in oscillation frequency of a 87Rb Bose-Einstein condensate trapped to a fused silica wall; the change is smaller than predicted by theory. We show that saturation effects can explain the discrepancies between theory and experiment observed in all these cases.

  11. Results of examinations of pressure vessel samples and instrument nozzles from the TMI-2 lower head

    Fifteen prism-shaped steel samples were removed from the lower head of the damaged TMI-2 reactor pressure vessel to assess the effects of approximately 19 metric tons of molten core debris that had relocated there during the 1979 loss-of-coolant accident. Metallographic examinations of the samples revealed that inside surface temperatures of 800 to 1,100 degree C were attained during the accident in an elliptical shaped ''hot spot'' ∼1 x 0.7 m. Tensile, creep, and Charpy V-notch specimens were also cut from the samples to assess the mechanical properties of the lower head material at temperatures up to the peak accident temperature. These properties were used in a margin to failure analysis of the lower head. Examinations of instrument nozzles removed from the lower head region assisted in defining the relocation scenario of the molten core debris and showed that the lower head was largely protected from catastrophic failure by a solidified layer around the molten core debris that acted as a partial thermal insulator

  12. STAR Trial Shows Lower Toxicities from Raloxifene

    Initial results in 2006 of the NCI-sponsored Study of Tamoxifen and Raloxifene (STAR) showed that a common osteoporosis drug, raloxifene, prevented breast cancer to the same degree, but with fewer serious side-effects, than the drug tamoxifen that had bee

  13. The Physics of Equestrian Show Jumping

    Stinner, Art

    2014-04-01

    This article discusses the kinematics and dynamics of equestrian show jumping. For some time I have attended a series of show jumping events at Spruce Meadows, an international equestrian center near Calgary, Alberta, often referred to as the "Wimbledon of equestrian jumping." I have always had a desire to write an article such as this one, but when I searched the Internet for information and looked at YouTube presentations, I could only find simplistic references to Newton's laws and the conservation of mechanical energy principle. Nowhere could I find detailed calculations. On the other hand, there were several biomechanical articles with empirical reports of the results of kinetic and dynamic investigations of show jumping using high-speed digital cameras and force plates. They summarize their results in tables that give information about the motion of a horse jumping over high fences (1.40 m) and the magnitudes of the forces encountered when landing. However, they do not describe the physics of these results.

  14. Investigation on the impact strength and toughness of A533 Grade B composition weld metal using small specimens

    An investigation was carried out to determine the impact strength and the fracture toughness of the multipass submerged arc (SA) weld metal of A533 grade B (20MnMoNi55) composition using Charpy V-notch and precracked Charpy-type specimens. The experimental results show that there is no large difference between the micro-hardness measured in the primary and secondary zones of the SA weld metal. The Charpy V-notch impact and fracture mechanics tests yield similar results in the primary and secondary zones. Nearly all specimens investigated exhibit the phenomenon of crack jump (pop-in of the load), that is, sudden cleavage or quasicleavage often followed by arrest of the crack

  15. Bill Kaffer shows advantages of voluntary audits

    Bader, C.D.

    1976-05-01

    Growing demands for commission-ordered management and operation audits are becoming commonplace. Recommendations by Mr. Kaffer of Theodore Barry and Associates show utilities that a 1 or 2 percent saving can result in millions in savings. The cost savings are spread over a wide range of functions, fuels management, work force management, vehicle usage, inventory management, construction management. The author points out that a voluntary audit enables an unhurried audit that will improve operations and save money, and the utilities will have a study report ready if an audit is ordered. A public stigma attached to a commission-ordered audit will be avoided. (MCW)

  16. Ancient bacteria show evidence of DNA repair

    Johnson, Sarah Stewart; Hebsgaard, Martin B; Christensen, Torben R; Mastepanov, Mikhail; Nielsen, Rasmus; Munch, Kasper; Brand, Tina; Gilbert, Tom; Zuber, Maria T; Bunce, Michael; Rnn, Regin; Gilichinsky, David; Froese, Duane; Willerslev, Eske

    2007-01-01

    Recent claims of cultivable ancient bacteria within sealed environments highlight our limited understanding of the mechanisms behind long-term cell survival. It remains unclear how dormancy, a favored explanation for extended cellular persistence, can cope with spontaneous genomic decay over......-term survival of bacteria sealed in frozen conditions for up to one million years. Our results show evidence of bacterial survival in samples up to half a million years in age, making this the oldest independently authenticated DNA to date obtained from viable cells. Additionally, we find strong evidence that...... this long-term survival is closely tied to cellular metabolic activity and DNA repair that over time proves to be superior to dormancy as a mechanism in sustaining bacteria viability....

  17. Experimental Drug for Rheumatoid Arthritis Shows Promise

    ... medlineplus/news/fullstory_158076.html Experimental Drug for Rheumatoid Arthritis Shows Promise Baricitinib helped patients who failed other ... 2016 (HealthDay News) -- An experimental drug to treat rheumatoid arthritis showed promise in a new six-month trial. ...

  18. The Language of Show Biz: A Dictionary.

    Sergel, Sherman Louis, Ed.

    This dictionary of the language of show biz provides the layman with definitions and essays on terms and expressions often used in show business. The overall pattern of selection was intended to be more rather than less inclusive, though radio, television, and film terms were deliberately omitted. Lengthy explanations are sometimes used to express…

  19. Parkinson's Drug Shows Promise Against Macular Degeneration

    ... nlm.nih.gov/medlineplus/news/fullstory_155695.html Parkinson's Drug Shows Promise Against Macular Degeneration But more ... THURSDAY, Nov. 12, 2015 (HealthDay News) -- A common Parkinson's disease medication might hold potential for preventing or ...

  20. UV Photography Shows Hidden Sun Damage

    ... Kids’ zone Video library Find a dermatologist UV photography shows hidden sun damage A UV photograph gives ... developing skin cancer and prematurely aged skin. Normal photography UV photography 18 months of age: This boy's ...

  1. New Dengue Virus Vaccine Shows Promise

    ... nih.gov/medlineplus/news/fullstory_157799.html New Dengue Virus Vaccine Shows Promise Research may also aid ... 16, 2016 (HealthDay News) -- An experimental vaccine against dengue -- the mosquito-borne virus behind a very painful ...

  2. Do dogs (Canis familiaris) show contagious yawning?

    Harr, Aimee L; Gilbert, Valerie R; Phillips, Kimberley A

    2009-11-01

    We report an experimental investigation into whether domesticated dogs display contagious yawning. Fifteen dogs were shown video clips of (1) humans and (2) dogs displaying yawns and open-mouth expressions (not yawns) to investigate whether dogs showed contagious yawning to either of these social stimuli. Only one dog performed significantly more yawns during or shortly after viewing yawning videos than to the open-mouth videos, and most of these yawns occurred to the human videos. No dogs showed significantly more yawning to the open-mouth videos (human or dog). The percentage of dogs showing contagious yawning was less than chimpanzees and humans showing this behavior, and considerably less than a recently published report investigating this behavior in dogs (Joly-Mascheroni et al. in Biol Lett 4:446-448, 2008). PMID:19452178

  3. New Drug Shows Promise Against Severe Sinusitis

    ... 157064.html New Drug Shows Promise Against Severe Sinusitis In early trial, dupilumab helped treat nasal polyps ... involving a group of patients struggling with chronic sinusitis. Dupilumab, which is injected, is aimed at helping ...

  4. Malaria Vaccine Shows Promise in Small Study

    ... nlm.nih.gov/medlineplus/news/fullstory_158765.html Malaria Vaccine Shows Promise in Small Study It protected ... TUESDAY, May 10, 2016 (HealthDay News) -- An experimental malaria vaccine protects a majority of adults against the ...

  5. Portable Zika Test Shows Promise in Monkeys

    ... nih.gov/medlineplus/news/fullstory_158704.html Portable Zika Test Shows Promise in Monkeys Easy-to-use ... News) -- A fast, inexpensive test that detects the Zika virus in monkeys might be useful for doctors ...

  6. Transplant Problems That May Show Up Later

    ... soon after transplant Next Topic Other transplant issues Transplant problems that may show up later The type ... called Second Cancers Caused by Cancer Treatment . Post-transplant lymphoproliferative disorder Post-transplant lymphoproliferative ( lim -fo-pruh- ...

  7. Interaction Management in Nigerian Television Talk Shows

    Albert Lekan Oyeleye; Omolara Grace Olutayo

    2012-01-01

    Although there is a growing number of works on discourse analysis in Nigeria which covers classroom interactions, courtroom discourse, medical communication and media discourse, the language of television (TV) talk shows has not been fully explored. This study therefore, examined turn management in this genre. It identified the turn distribution strategies in Nigerian television talk shows and the contributions of these strategies to the management of the talks. Sacks, Schegloff and Jefferson...

  8. Educational Outreach: The Space Science Road Show

    Cox, N. L. J.

    2002-01-01

    The poster presented will give an overview of a study towards a "Space Road Show". The topic of this show is space science. The target group is adolescents, aged 12 to 15, at Dutch high schools. The show and its accompanying experiments would be supported with suitable educational material. Science teachers at schools can decide for themselves if they want to use this material in advance, afterwards or not at all. The aims of this outreach effort are: to motivate students for space science and engineering, to help them understand the importance of (space) research, to give them a positive feeling about the possibilities offered by space and in the process give them useful knowledge on space basics. The show revolves around three main themes: applications, science and society. First the students will get some historical background on the importance of space/astronomy to civilization. Secondly they will learn more about novel uses of space. On the one hand they will learn of "Views on Earth" involving technologies like Remote Sensing (or Spying), Communication, Broadcasting, GPS and Telemedicine. On the other hand they will experience "Views on Space" illustrated by past, present and future space research missions, like the space exploration missions (Cassini/Huygens, Mars Express and Rosetta) and the astronomy missions (Soho and XMM). Meanwhile, the students will learn more about the technology of launchers and satellites needed to accomplish these space missions. Throughout the show and especially towards the end attention will be paid to the third theme "Why go to space"? Other reasons for people to get into space will be explored. An important question in this is the commercial (manned) exploration of space. Thus, the questions of benefit of space to society are integrated in the entire show. It raises some fundamental questions about the effects of space travel on our environment, poverty and other moral issues. The show attempts to connect scientific with community thought. The difficulty with a show this elaborate and intricate is communicating on a level understandable for teenagers, whilst not treating them like children. Professional space scientists know how easy it is to lose oneself in technical specifics. This would, of course, only confuse young people. The author would like to discuss the ideas for this show with a knowledgeable audience and hopefully get some (constructive) feedback.

  9. 2008 LHC Open Days Physics: the show

    2008-01-01

    A host of events and activities await visitors to the LHC Open Days on 5 and 6 April. A highlight will be the physics shows funded by the European Physical Society (EPS), which are set to surprise and challenge children and adults alike! School children use their experience of riding a bicycle to understand how planets move around the sun (Copyright : Circus Naturally) Participating in the Circus Naturally show could leave a strange taste in your mouth! (Copyright : Circus Naturally) The Rino Foundation’s experiments with liquid nitrogen can be pretty exciting! (Copyright: The Rino Foundation)What does a bicycle have in common with the solar system? Have you ever tried to weigh air or visualise sound? Ever heard of a vacuum bazooka? If you want to discover the answers to these questions and more then come to the Physics Shows taking place at the CERN O...

  10. Converting Pet Shows game to Unity environment

    Pulkkinen, Toni

    2015-01-01

    The purpose of this thesis was to convert one of the minigames in Pet Shows from HTML5-based to work in Unity environment. The goal was to get Pet Shows in an environment where it would be possible to try developing it further for Android operating system. The possibilities and requirements to start developing on Android platform were also researched. The customer of this thesis was Seepia Games. The minigame was made by using Unity game engine utilizing its 2D-features. The programming w...

  11. La mujer, en los talk shows

    Antrop. José Gamboa Cetina

    2001-01-01

    Dentro de los medios de comunicación, uno de los que más ha impactado a la población latinoamericana ha sido la televisión, y en la barra programática de las televisoras ha surgido un tipo de programas denominados talk shows. En los últimos meses, la sociedad mexicana ha vivido el "boom" de los talk shows, que en poco tiempo han saturado la barra de la programación vespertina de las dos principales empresas televisivas de la república mexicana. Este fenómeno puede estudiarse desde diversas pe...

  12. Liquid Crystal Research Shows Deformation By Drying

    2003-01-01

    These images, from David Weitz's liquid crystal research, show ordered uniform sized droplets (upper left) before they are dried from their solution. After the droplets are dried (upper right), they are viewed with crossed polarizers that show the deformation caused by drying, a process that orients the bipolar structure of the liquid crystal within the droplets. When an electric field is applied to the dried droplets (lower left), and then increased (lower right), the liquid crystal within the droplets switches its alignment, thereby reducing the amount of light that can be scattered by the droplets when a beam is shone through them.

  13. Show Them You Really Want the Job

    Perlmutter, David D.

    2012-01-01

    Showing that one really "wants" the job entails more than just really wanting the job. An interview is part Broadway casting call, part intellectual dating game, part personality test, and part, well, job interview. When there are 300 applicants for a position, many of them will "fit" the required (and even the preferred) skills listed in the job…

  14. Creating a Slide-Tape Show.

    Kert, Isabel

    1980-01-01

    The opportunities for real language use in creating a slide show in the language class are described. Fifteen steps for replicating the project are included. Students choose the topic, develop the story line, create the dialogue, take the photographs, write the script, and act the roles. (PMJ)

  15. Showing Enantiomorphous Crystals of Tartaric Acid

    Andrade-Gamboa, Julio

    2007-01-01

    Most of the articles and textbooks that show drawings of enantiomorphous crystals use an inadequate view to appreciate the fact that they are non-superimposable mirror images of one another. If a graphical presentation of crystal chirality is not evident, the main attribute of crystal enantiomorphism can not be recognized by students. The classic

  16. Eclipsing Binaries Showing Light Time Effect

    Zasche, Petr

    2007-01-01

    Four eclipsing binaries, which show apparent changes of period, have been studied with respect to a possible presence of the light time effect. With a least squares method we calculated new light elements of these systems, the mass function of the predicted third body, and its minimum mass. We discuss the probability of the presence of such bodies in terms of mass function, changes in radial velocity and third light in solution of light curves.

  17. Map showing depth to bedrock, Anchorage, Alaska

    Glass, R.L.

    1988-01-01

    Knowledge of the physical and hydrologic characteristics of geologic materials is useful in determining the availability of groundwater for public and domestic supply and the suitability of areas for on-site septic systems. A generalized map of the Anchorage area shows the approximate distance from land surface to the top of the bedrock surface. Four depth zones are shown. The depths were determined from lithologic data contained in drillers ' logs. (USGS)

  18. Pigeons, Rats, and Humans Show Analogous Misinformation

    Garry, Maryanne; Harper, David N

    2009-01-01

    In three experiments, we show that pigeons, rats and humans can be influenced by misleading postevent information in ways analogous to findings in the human memory distortion literature. We used a delayed matching to sample analog of the eyewitness testimony procedure from Loftus et al.(1978), and varied the length of the delay between event and exposure to post event information(PEI). We also varied the nature of PEI so that it was consistent with the event information, inconsistent, or neut...

  19. Reality, ficción o show

    Sandra Ruíz Moreno

    2002-01-01

    Full Text Available Para tener un punto de vista claro y objetivo frente a la polémica establecida en torno al programa “Protagonistas de novela” y la tendiente proliferación de los reality show en las parrillas de programación de la televisión colombiana, se realizó un análisis de texto y contenido de dicho programa, intentando definirlo desde sus posibilidades de realidad, ficción y show. Las unidades de análisis y el estudio de su tratamiento arrojaron un alto contenido que gira en torno a las emociones del ser humano relacionadas con la convivencia, tratadas a manera de show y con algunos aportes textuales de ficción, pero sin su elemento mediador básico, el actor, quitándole toda la posibilidad de tener un tratamiento con la profundidad, distancia y ética que requieren los temas de esta índole. El resultado es un formato que sólo busca altos índices de sintonía y que pertenece más a la denominada televisión “trash”, que a una búsqueda de realidad del hombre y mucho menos de sociedad.

  20. Mercury's Core Molten, Radar Study Shows

    2007-05-01

    Scientists using a high-precision planetary radar technique for the first time have discovered that the innermost planet Mercury probably has a molten core, resolving a mystery of more than three decades. The discovery, which used the National Science Foundation's Robert C. Byrd Green Bank Telescope in West Virginia and Arecibo Observatory in Puerto Rico, and NASA/Jet Propulsion Laboratory antennas in California, is an important step toward a better understanding of how planets form and evolve. Planetary Radar High-precision planetary radar technique sent signal to Mercury, received reflection. CREDIT: Bill Saxton, NRAO/AUI/NSF Click on image for high-resolution file (447 KB) "For a long time it was thought we'd have to land spacecraft on Mercury to learn if its core is solid or molten. Now we've answered that question using ground-based telescopes," said Jean-Luc Margot, of Cornell University, leader of the research team, which published its results in the May 4 issue of the journal Science. Mercury is one of the least-understood of the planets in our Solar System. Its distance from the Sun is just over one-third that of the Earth, and it contains a mass just 5 percent that of Earth. Only about half of Mercury's surface has been photographed by a spacecraft, Mariner 10, back in 1974. Mariner 10 also discovered that Mercury has a weak magnetic field, about one percent as strong as Earth's. That discovery spurred a scientific debate about the planet's core. Scientists normally expect a rocky planet's magnetic field to be caused by an electromagnetic dynamo in a molten core. However, Mercury is so small that most scientists expected its core to have cooled and solidified long ago. Those scientists speculated that the magnetic field seen today may have been "frozen" into the planet when the core cooled. "Whether the core is molten or solid today depends greatly on the chemical composition of the core. That chemical composition can provide important clues about the processes involved in planet formation," Margot said. To answer the question, the scientists implemented an ingenious, high-precision technique in which they sent a powerful beam of radio waves to bounce off Mercury, then received and analyzed the reflected signal using pairs of ground-based radio telescopes. While similar radar systems have been used in the past to map planetary surfaces, this technique instead measured the rate at which Mercury spins on its axis, and did so with an unprecedented precision of one part in 100,000. By making 21 separate observations, the research team was able to measure minute variations in the planet's spin rate. This was the key to learning whether Mercury's core is solid or molten. Using an understanding of the Sun's gravitational effect on the planet, they realized that the tiny variations in its spin rate would be twice as large if the core is liquid than they would be if Mercury has a solid core. "The variations in Mercury's spin rate that we measured are best explained by a core that is at least partially molten. We have a 95 percent confidence level in this conclusion," Margot said. For most of their observations, carried out from 2002-2006, the scientists transmitted a powerful radar beam from the NASA/JPL 70-meter antenna at Goldstone, California, and received the reflected signal with the Green Bank Telescope and the Goldstone antenna. For some observations, they transmitted from the Arecibo Observatory in Puerto Rico and received at Arecibo and two Goldstone antennas. They used radar signals at frequencies of 8.5 and 2.4 GHz. To make the precision measurements of Mercury's spin rate, the geometry between the planet and the receiving antennas had to match a specific alignment. Such an alignment only occurs for about 20 seconds a day. In addition to measuring Mercury's spin rate, their technique also made the best measurement ever of the alignment of the planet's axis of rotation. "We improved the accuracy of this measurement by 100 times, and showed that Mercury's spin axis

  1. Software for portable laser light show system

    Buruchin, Dmitrey J.; Leonov, Alexander F.

    1995-04-01

    Portable laser light show system LS-3500-10M is connected to the parallel port of IBM PC/AT compatible computer. Computer performs output of digital control data describing images. Specially designed control device is used to convert digital data coming from parallel port to the analog signal driving scanner. Capabilities of even cost nothing 286 computer are quite enough for laser graphics control. Technology of scanning used in laser graphics system LS-3500-10M essentially differs from widely spread systems based on galvanometers with mobile core or with mobile magnet. Such devices are based on the same principle of work as electrically driven servo-mechanism. As scanner we use elastic system with hydraulic dampen oscillations and opened loop. For most of applications of laser graphics such system provides satisfactory precision and speed of scanning. LS-3500-10M software gives user ability to create on PC and play his own laser graphics demonstrations. It is possible to render recognizable text and pictures using different styles, 3D and abstract animation. All types of demonstrations can be mixed in slide-show. Time synchronization is supported. Software has the following features: (1) Different types of text output. Built-in text editor for typing and editing of textural information. Different fonts can be used to display text. User can create his own fonts using specially developed font editor. (2) Editor of 3D animation with library of predefined shapes. (3) Abstract animation provided by software routines. (4) Support of different graphics files formats (PCX or DXF). Original algorithm of raster image tracing was implemented. (5) Built-in slide-show editor.

  2. Clathrin Triskelia Show Evidence of Molecular Flexibility

    Ferguson, Matthew L.; Prasad, Kondury; Boukari, Hacene; Sackett, Dan L; Krueger, Susan; Lafer, Eileen M.; Nossal, Ralph

    2008-01-01

    The clathrin triskelion, which is a three-legged pinwheel-shaped heteropolymer, is a major component in the protein coats of certain post-Golgi and endocytic vesicles. At low pH, or at physiological pH in the presence of assembly proteins, triskelia will self-assemble to form a closed clathrin cage, or basket. Recent static light scattering and dynamic light scattering studies of triskelia in solution showed that an individual triskelion has an intrinsic pucker similar to, but differing fro...

  3. Latest European coelacanth shows Gondwanan affinities.

    Cavin, Lionel; Forey, Peter L; Buffetaut, Eric; Tong, Haiyan

    2005-06-22

    The last European fossil occurrence of a coelacanth is from the Mid-Cretaceous of the English Chalk (Turonian, 90 million years ago). Here, we report the discovery of a coelacanth from Late Cretaceous non-marine rocks in southern France. It consists of a left angular bone showing structures that imply close phylogenetic affinities with some extinct Mawsoniidae. The closest relatives are otherwise known from Cretaceous continental deposits of southern continents and suggest that the dispersal of freshwater organisms from Africa to Europe occurred in the Late Cretaceous. PMID:17148159

  4. Are Corporate Universities (CU possible in emerging countries? A survey conducted in Argentina showed impacting results

    Leandro A. Viltard

    2014-09-01

    Full Text Available At the time of our investigation, the CU was not a widespread concept in Argentina, being viewed as a “foreign - far long project” (coming from developed countries and standing for the long term. It is suggested that the rate of CU evolution, in emerging countries like Argentina, is more related to mentality issues than to CU strategic or operative limitations. Although the executives who replied to a survey were not the only power factor in their organization, their comments allow us to think that, in those countries, the CU may have a better future perspective. The research used a quali-quantitative methodology, which was based on a survey to top executives of different kinds of companies located in Argentina. The research design was not experimental and transversal, as it was limited to a specific moment in time.

  5. Tomato Fruits Show Wide Phenomic Diversity but Fruit Developmental Genes Show Low Genomic Diversity

    Mohan, Vijee; Gupta, Soni; Thomas, Sherinmol; Mickey, Hanjabam; Charakana, Chaitanya; Chauhan, Vineeta Singh; Sharma, Kapil; Kumar, Rakesh; Tyagi, Kamal; Sarma, Supriya; Gupta, Suresh Kumar; Kilambi, Himabindu Vasuki; Nongmaithem, Sapana; Kumari, Alka; Gupta, Prateek; Sreelakshmi, Yellamaraju; Sharma, Rameshwar

    2016-01-01

    Domestication of tomato has resulted in large diversity in fruit phenotypes. An intensive phenotyping of 127 tomato accessions from 20 countries revealed extensive morphological diversity in fruit traits. The diversity in fruit traits clustered the accessions into nine classes and identified certain promising lines having desirable traits pertaining to total soluble salts (TSS), carotenoids, ripening index, weight and shape. Factor analysis of the morphometric data from Tomato Analyzer showed that the fruit shape is a complex trait shared by several factors. The 100% variance between round and flat fruit shapes was explained by one discriminant function having a canonical correlation of 0.874 by stepwise discriminant analysis. A set of 10 genes (ACS2, COP1, CYC-B, RIN, MSH2, NAC-NOR, PHOT1, PHYA, PHYB and PSY1) involved in various plant developmental processes were screened for SNP polymorphism by EcoTILLING. The genetic diversity in these genes revealed a total of 36 non-synonymous and 18 synonymous changes leading to the identification of 28 haplotypes. The average frequency of polymorphism across the genes was 0.038/Kb. Significant negative Tajima’D statistic in two of the genes, ACS2 and PHOT1 indicated the presence of rare alleles in low frequency. Our study indicates that while there is low polymorphic diversity in the genes regulating plant development, the population shows wider phenotype diversity. Nonetheless, morphological and genetic diversity of the present collection can be further exploited as potential resources in future. PMID:27077652

  6. Cold-fusion television show angers APS

    Cartwright, Jon

    2009-06-01

    Cold fusion has been controversial since its inception on 23 March 1989, when chemists Martin Fleischmann and Stanley Pons at the University of Utah in the US announced that they had achieved a sustained nuclear-fusion reaction at room temperature. Two decades on, a US television documentary about the field has stirred up fresh debate after it linked the American Physical Society (APS) to an evaluation of some cold-fusion results by Robert Duncan, a physicist and vice chancellor of the University of Missouri.

  7. Temperature Data Shows Warming in 2001

    2002-01-01

    TThe figure above depicts how much air temperatures near the Earth's surface changed relative to the global mean temperature from 1951 to 1980. NASA researchers used maps of urban areas derived from city lights data to account for the 'heat island' effect of cities. The red and orange colors show that temperatures are warmer in most regions of the world when compared to the 1951 to 1980 'normal' temperatures. Warming around the world has been widespread, but it is not present everywhere. The largest warming is in Northern Canada, Alaska and Siberia, as indicated by the deeper red colors. The lower 48 United States have become warmer recently, but only enough to make the temperatures comparable to what they were in the 1930s. The scale on the bottom of these temperature anomaly images represent degrees in Celsius. The negative numbers represent cooling and the positive numbers depict warming. Overall, the air temperature near the Earth's surface has warmed by 1oF (0.6oC) globally, on average, over the last century. For more information and additional images, read Satellites Shed Light on a Warmer World. Image courtesy Goddard Institute for Space Studies (GISS).

  8. Bacteriophages show promise as antimicrobial agents.

    Alisky, J; Iczkowski, K; Rapoport, A; Troitsky, N

    1998-01-01

    The emergence of antibiotic-resistant bacteria has prompted interest in alternatives to conventional drugs. One possible option is to use bacteriophages (phage) as antimicrobial agents. We have conducted a literature review of all Medline citations from 1966-1996 that dealt with the therapeutic use of phage. There were 27 papers from Poland, the Soviet Union, Britain and the U.S.A. The Polish and Soviets administered phage orally, topically or systemically to treat a wide variety of antibiotic-resistant pathogens in both adults and children. Infections included suppurative wound infections, gastroenteritis, sepsis, osteomyelitis, dermatitis, empyemas and pneumonia; pathogens included Staphylococcus, Streptococcus, Klebsiella, Escherichia, Proteus, Pseudomonas, Shigella and Salmonella spp. Overall, the Polish and Soviets reported success rates of 80-95% for phage therapy, with rare, reversible gastrointestinal or allergic side effects. However, efficacy of phage was determined almost exclusively by qualitative clinical assessment of patients, and details of dosages and clinical criteria were very sketchy. There were also six British reports describing controlled trials of phage in animal models (mice, guinea pigs and livestock), measuring survival rates and other objective criteria. All of the British studies raised phage against specific pathogens then used to create experimental infections. Demonstrable efficacy against Escherichia, Acinetobacter, Pseudomonas and Staphylococcus spp. was noted in these model systems. Two U.S. papers dealt with improving the bioavailability of phage. Phage is sequestered in the spleen and removed from circulation. This can be overcome by serial passage of phage through mice to isolate mutants that resist sequestration. In conclusion, bacteriophages may show promise for treating antibiotic resistant pathogens. To facilitate further progress, directions for future research are discussed and a directory of authors from the reviewed papers is provided. PMID:9515662

  9. BROOKHAVEN: ISABELLE magnets show their paces

    While funding for the ISABELLE 400 GeV proton-proton collider project is yet to be finalized, development continues of the superconducting magnets for this machine. Encouraging results have been achieved so far in the 'training' of four of the magnets operated in liquid helium at 4.5 K. All operate above the design field, corresponding to a proton beam energy of 400 GeV. Tests are under way on the magnets' resilience to quenches. Investigations of field quality were not among the objectives with these first magnets, but will be carried out with the short dipoles now under construction. The magnets seem well on the way to being able to meet the required conditions, and work continues apace

  10. Do Education Organizations Show Learning Organizations Charecterics?

    Sedat Yumusak,

    Full Text Available Learning, an important element in terms of affecting the change of individual, organizational and social structures, will occur more effectively when the institutions in social structure turn into learning organizations. Senge (1993 concept of learning organization, constantly changing, evolving and renewing itself described as a dynamic structure. This concept has an important place in all institutions is also a separate meaning for educational institutions. In this context, schools training the human resources, appropriate for the aim of being information society, as individuals have taken continuous learning as their principles, teachers providing educational and supporting services and their perceptions of learning organization are of the great importance. In Balıkesir, the study was conducted virtue of this importance has been serving the state and private institutions serving 848 elementary teachers, perceptions of the learning organization and organizational barriers that prevent it is to be determined through a comparative analysis. As a result of the survey, in the framework of the bases in literature, it has been found out that the state primary schools don’t have the features of learning organization, contrary to the private primary schools.

  11. TAPS repair shows value of deformation monitoring

    Simmons, G.G.; Ferrell, J.F.

    1986-04-07

    For Arctic pipelines, especially those built in river and floodplain areas, a monitoring system is essential for detecting impending pipe damage. This was a major lesson derived from last year's repair and rerouting of a section of the Trans-Alaska Pipeline (TAPS) at milepost (mp) 200. The line at this point crosses a river and floodplain area in which any surface evidence of pipe damage is obliterated, thus making ground surface conditions unreliable indicators of pipe settlement. The wintertime repair project, with rerouted pipe of about 4,000 ft long, cost $27 million. The affected pipe was buried beneath the main channel of the Dietrich River, 200.6 miles from the beginning of the pipeline at Prudhoe Bay, and 84 miles above the Arctic Circle. As part of Alyeska's continuing monitoring program, a corrosion and deformation (C/D) pig traverses the TAPS pipe at regular intervals. This pig has proven helpful in locating places where excessive settlement has caused deformation of the pipe. The C/D pig detects pipe diameter changes as small as 0.25 in. The radial and longitudinal locations of the pipe change have proven quite accurate. A review of the results of the June 1984 C/D pig run revealed a pipe wall ovality anomaly with a sinusoidal shape indicating a wrinkle. This wrinkle was small when compared with other wrinkles Alyeska had found and subsequently repaired. A comparison of previous C/D pig runs for this location revealed a wrinkle with an amplitude of 0.25 in. which had developed in previously smooth pipe in the space of a year.

  12. Conservation Project Shows Substantial Reduction in Home Water Use

    Sharpe, William E.; Smith, Donald

    1978-01-01

    Describes a water use study-conservation project conducted by the Washington Suburban Sanitary Commission in Maryland. Results show a significant decrease in the amount of water used by home customers over a ten-year period. (Author/MA)

  13. NoChintz Show Homes: Development of a show home interior design company

    Perry, Natalie Faye

    2010-01-01

    The aim of this project is to develop a business area of NoChintz Ltd. into a profitable enterprise. NoChintz Show Homes will provide show home interior design services to the property industry.A case study investigation into a completed show home interior has been undertaken to facilitate understanding of the design service process, highlighting successful practice and opportunities for improvement.Following the investigation market research, business planning and financial analysis have bee...

  14. Show Horse Welfare: The Viewpoints of Judges, Stewards, and Show Managers.

    Voigt, Melissa; Hiney, Kristina; Croney, Candace; Waite, Karen; Borron, Abigail; Brady, Colleen

    2016-01-01

    The purpose of this study was to gain a better understanding of the current state of stock-type show horse welfare based on the perceptions of show officials and to identify potential means of preventing and intervening in compromises to show horse welfare. Thirteen horse show officials, including judges, stewards, and show managers, were interviewed. Findings revealed the officials had an incomplete understanding of nonhuman animal welfare and a high level of concern regarding the public's perception of show horse welfare. The officials attributed most of the frequently observed compromises to show horse welfare to (a) novices', amateurs', and young trainers' lack of experience or expertise, and (b) trainers' and owners' unrealistic expectations and prioritization of winning over horse welfare. The officials emphasized a need for distribution of responsibility among associations, officials, and individuals within the industry. Although the officials noted recent observable positive changes in the industry, they emphasized the need for continued improvements in equine welfare and greater educational opportunities for stakeholders. PMID:26742585

  15. Flashlight und Lichtorgel: Englischunterricht als Show (Flashlight and Lighting Console: English Teaching as a Show).

    Boettcher, Karl-Heinz

    1978-01-01

    Reports on using amateur theatricals in fifth-grade English classes as a motivating device. The project developed into a "show," which was performed publicly. Practical problems are discussed. The project is evaluated and suggestions are offered for other teachers. (IFS/WGA)

  16. Best in show but not best shape: a photographic assessment of show dog body condition.

    Such, Z R; German, A J

    2015-08-01

    Previous studies suggest that owners often wrongly perceive overweight dogs to be in normal condition. The body shape of dogs attending shows might influence owners' perceptions, with online images of overweight show winners having a negative effect. This was an observational in silico study of canine body condition. 14 obese-prone breeds and 14 matched non-obese-probe breeds were first selected, and one operator then used an online search engine to identify 40 images, per breed, of dogs that had appeared at a major national UK show (Crufts). After images were anonymised and coded, a second observer subjectively assessed body condition, in a single sitting, using a previously validated method. Of 1120 photographs initially identified, 960 were suitable for assessing body condition, with all unsuitable images being from longhaired breeds. None of the dogs (0 per cent) were underweight, 708 (74 per cent) were in ideal condition and 252 (26 per cent) were overweight. Pugs, basset hounds and Labrador retrievers were most likely to be overweight, while standard poodles, Rhodesian ridgebacks, Hungarian vizslas and Dobermanns were least likely to be overweight. Given the proportion of show dogs from some breeds that are overweight, breed standards should be redefined to be consistent with a dog in optimal body condition. PMID:26169655

  17. Managing Trade Show Campaigns:Why Managerial Responsibilities Matter?

    Tafesse, Wondwesen; Korneliussen, Tor

    2012-01-01

    This article examined the relationship between managerial responsibilities for important trade show tasks and the marketing performance of exhibiting firms. Drawing theoretical insights from the functionalist perspective of managerial roles and organizational role theory, this article proposed and validated theory based, multiple, task-managerial responsibility linkages using a large international b2b trade show as a context. The empirical results indicated that the marketing performance of e...

  18. Attitudes towards disability showed by future physical education teachers

    Jorge Abelln Hernndez

    2015-01-01

    The present paper aims to study the attitudes towards disability of future physical education teachers. For this purpose two questionnaires were administered and the results were compared by gender (male and female), the participants' experience in dealing with people with disabilities and the particants course level (third or fourth grade). The results show that students in the Minor in Physical Education have a very positive attitude towards disability. Men obtain a more positive attitude ...

  19. Computer-Assisted Instruction: What the Research Shows.

    Bracey, Gerald W.

    1987-01-01

    Briefly reviews current research on the effectiveness of computer-assisted instruction (CAI) and microcomputers. The Hawthorne Effect and research results for elementary, secondary, and college level students are discussed, courseware requirements are described, and research studies showing positive and negative effects of CAI are listed. (LRW)

  20. Intercan '99 - the Calgary oil and gas show: official show guide

    The official show guide features a list of exhibitor profiles and list of products and services. A leading technology seminar series, held during Intercan '99 presented 47 papers on such topics as economically viable benzene pollution solution, micro turbines for effective flare gas treatment, cost effective and technologically advanced silicated drilling fluids, pressure enhancement of marginal gas, predictive maintenance tools, advantages of the inclined free water knockout (IFWKO), isotherm systems, hands-free automatic oil well optimization, on-site bioremediation of hydrocarbon contaminated drill cuttings through composting technologies, a new environmentally acceptable drill mud oil and real-time well monitoring case studies. Papers were also presented on: Exacta's all in one series XI controller for air/fuel radio control, more efficient and cost effective coiled tubing technology, pressure enhancement of marginal gas, hands-free automatic oil well optimization, economically viable benzene pollution solution, new products to solve the soluble salt dilemma, real-time hydrocarbon reservoir management using PC based reservoir simulators,real-time bottom hole pressure monitoring system for fracturing operations and remote modular facilities and accommodation for maximized personnel productivity

  1. Deaf children's spelling: does it show sensitivity to phonology?

    Sutcliffe, A; Dowker, A; Campbell, R

    1999-01-01

    A written pictures to spelling task was given to two groups of children, 17 deaf children from signing schools (average age = 10.7) and 20 hearing children learning English as a second language (ESL, average age = 10.4). The stimuli were equally divided according to frequency, phonological regularity, and orthographic regularity. We predicted that the deaf group would not differ from the ESL group in the pattern of their responses across word classes, categorized in terms of the effect of frequency and phonological and orthographic regularity. Results showed that broadly this was the case, but more detailed analysis showed that the approach of the two groups was different. More specifically, the deaf children appeared to be sensitive to, but not aware of, phonology in their spelling, whereas the ESL group showed awareness of, as well as sensitivity to, phonology in their spelling. PMID:15579881

  2. Mutants Showing Heterothallism from a Homothallic Strain of SACCHAROMYCES CEREVISIAE

    Oshima, Takehiro; Takano, Isamu

    1980-01-01

    Mutants defective in mating-type conversion were isolated from ascospores of a perfect homothallism strain having the HO HMRa HML? genotype. Eighty mutants, including 11 temperature-dependent mutants showing a or ? mating potency, were isolated from 10,050 colonies derived from spores mutagenized with ethyl methanesulfonate. Of the 80 mutants, 48 were tested by crossing with an ho HMRa HML? heterothallic and an HO HMRa HML? homothallic strain as standards. The results allowed their division i...

  3. Influence of process parameters on the weld lines of a micro injection molded component

    Tosello, Guido; Gava, Alberto; Hansen, Hans Nørgaard; Lucchetta, Giovanni

    2007-01-01

    The insufficient entanglement of the molecular chains and the stress amplification at the v-notch of a weld line compromise the mechanical strength of a plastic product, also in the micro scale. To investigate the influence of process parameters on the weld lines formation, a special micro cavity...... was designed and manufactured by µEDM (Electro Discharge Machining). Weld lines were quantitatively characterized both in the two-dimensional (direction and position) and three-dimensional range (surface topography characterization). Results showed that shape and position of weld lines are mainly...

  4. Effect of copper content on the microstructure and mechanical properties of multipass MMA, low alloy steel weld metal deposits

    Effect of copper content in the range of 0.14-0.94 wt.% on the microstructure and mechanical properties of Cr-Ni-Cu low alloy steel weld metal deposits was investigated. All welds were prepared by manual metal arc welding technique in flat position. Microstructure of the welds was examined by optical and scanning electron microscopes. The results showed increase in acicular ferrite and microphases formed at the expense of primary ferrite and ferrite with second phase with steady refinement of microstructure. According to these microstructural changes, hardness, yield and ultimate tensile stresses increased while Charpy V-notch impact toughness and percent elongation reduced.

  5. Learning from a dive show in an aquarium setting

    Walsh, Lori M.

    A study was conducted at an aquarium next to a theme park to understand information recalled from two versions of shows viewed at the largest display. The goal of this research was to determine if learning was enhanced by having a diver in water as the treatment group. This project focused on the knowledge recalled about shark and ray feeding adaptations, the information recalled about the mentioned conservation message about sustainable seafood and the potential of the two shows to make memorable experiences. During the project, 30 adult participants from each group were given a survey with five open-ended questions. Results suggest that the diver might distract from biological content information, or that the diver is such a novel element that it interferes with recall. While guests seemed to recall information about rays and sharks, the amount of information was not substantial. It appears that the diver does not affect content messaging but does impact whether guests attend to Seafood Watch messaging. The diver may have been so novel that the treatment group could not attend to the conservation message that was delivered, regardless of topic, or the control group recalled the message because the guests were not distracted by the diver or feeding. The absence of a diver seems to allow the guests to better attend to what is happening outside of the tank. While adding a diver increases photo opportunities and may bring guests to a show, the results seem to indicate that it does not significantly increase recall. The results of this study show that guests in a theme park setting can recall information from an educational program. Guests may not enter this hybrid aquarium with the intention of learning, but recall, one of the components in learning, does occur.

  6. Measuring political polarization: Twitter shows the two sides of Venezuela

    Morales, A. J.; Borondo, J.; Losada, J. C.; Benito, R. M.

    2015-03-01

    We say that a population is perfectly polarized when divided in two groups of the same size and opposite opinions. In this paper, we propose a methodology to study and measure the emergence of polarization from social interactions. We begin by proposing a model to estimate opinions in which a minority of influential individuals propagate their opinions through a social network. The result of the model is an opinion probability density function. Next, we propose an index to quantify the extent to which the resulting distribution is polarized. Finally, we apply the proposed methodology to a Twitter conversation about the late Venezuelan president, Hugo Chávez, finding a good agreement between our results and offline data. Hence, we show that our methodology can detect different degrees of polarization, depending on the structure of the network.

  7. Measuring Political Polarization: Twitter shows the two sides of Venezuela

    Morales, A J; Losada, J C; Benito, R M

    2015-01-01

    We say that a population is perfectly polarized when divided in two groups of the same size and opposite opinions. In this paper, we propose a methodology to study and measure the emergence of polarization from social interactions. We begin by proposing a model to estimate opinions in which a minority of influential individuals propagate their opinions through a social network. The result of the model is an opinion probability density function. Next, we propose an index to quantify the extent to which the resulting distribution is polarized. Finally, we apply the proposed methodology to a Twitter conversation about the late Venezuelan president, Hugo Ch\\'avez, finding a good agreement between our results and offline data. Hence, we show that our methodology can detect different degrees of polarization, depending on the structure of the network.

  8. Bonobos (Pan paniscus) show an attentional bias toward conspecifics’ emotions

    Kret, Mariska E.; Jaasma, Linda; Bionda, Thomas; Wijnen, Jasper G.

    2016-01-01

    In social animals, the fast detection of group members’ emotional expressions promotes swift and adequate responses, which is crucial for the maintenance of social bonds and ultimately for group survival. The dot-probe task is a well-established paradigm in psychology, measuring emotional attention through reaction times. Humans tend to be biased toward emotional images, especially when the emotion is of a threatening nature. Bonobos have rich, social emotional lives and are known for their soft and friendly character. In the present study, we investigated (i) whether bonobos, similar to humans, have an attentional bias toward emotional scenes compared with conspecifics showing a neutral expression, and (ii) which emotional behaviors attract their attention the most. As predicted, results consistently showed that bonobos’ attention was biased toward the location of the emotional versus neutral scene. Interestingly, their attention was grabbed most by images showing conspecifics such as sexual behavior, yawning, or grooming, and not as much—as is often observed in humans—by signs of distress or aggression. The results suggest that protective and affiliative behaviors are pivotal in bonobo society and therefore attract immediate attention in this species. PMID:26976586

  9. The AIDS prevention magic show: avoiding the tragic with magic.

    Lustig, S L

    1994-01-01

    Teenagers are a crucial target group for interventions concerning acquired immunodeficiency syndrome (AIDS) and human immunodeficiency virus (HIV). Experimenting with their burgeoning sexuality and increased ability to obtain drugs, they are prime candidates for AIDS prevention and education strategies. The intervention described in this paper is a 30-minute magic show, presented by Cyrus (or Iris) the Virus, a sinister but entertaining character portrayed by any health educator willing to spend a few hours learning the magic tricks. The tricks explain why sharing needles and choosing sexual partners based on appearance alone can result in AIDS. Cyrus also uses magic to communicate the ways that AIDS is not transmitted, how to refuse sex, and how to use condoms correctly. The show, as well as increasing the audience's knowledge about HIV, attempts to induce behavioral change by increasing participants' perceived self-efficacy--a predictor of healthful behavior. Still in its pilot phase, the show has been seen by 281 students ages 10-15 years. Viewers rate the show highly, and preliminary analysis suggests that perceived self-efficacy has been significantly improved. PMID:8153267

  10. Enceladus Results

    National Aeronautics and Space Administration — Here are some results from the Spectra Decomposition Algorithm on infrared spectral images of Saturn's moon Enceladus. Figure 1 is the spatial contribution of the...

  11. 1998 results

    This document presents the financial and commercial results of Gaz de France (GdF) company for 1998. The following points are presented successively: financial results (budget results, turnover, self-financing capacity, investments, debt situation), commercial results (some remarkable numbers and records, the tertiary and residential market, the industrial market, cogeneration and natural gas for vehicles), the strategy, 1998 realizations and perspectives (the natural gas energy in the 21. century, the development of GdF, the gas distribution and services (development of the French distribution system, export of the know-how, development of services), the transportation and storage systems threw Europe (densification of the pipeline network, the key-position of France, the north-south equilibrium of the distribution network), the natural gas production by GdF, the diversification of supplies, and the main daughter companies abroad). (J.S.)

  12. Recurrent and multiple bladder tumors show conserved expression profiles

    Knuutila Sakari

    2008-06-01

    Full Text Available Abstract Background Urothelial carcinomas originate from the epithelial cells of the inner lining of the bladder and may appear as single or as multiple synchronous tumors. Patients with urothelial carcinomas frequently show recurrences after treatment making follow-up necessary. The leading hypothesis explaining the origin of meta- and synchronous tumors assumes a monoclonal origin. However, the genetic relationship among consecutive tumors has been shown to be complex in as much as the genetic evolution does not adhere to the chronological appearance of the metachronous tumors. Consequently, genetically less evolved tumors may appear chronologically later than genetically related but more evolved tumors. Methods Forty-nine meta- or synchronous urothelial tumors from 22 patients were analyzed using expression profiling, conventional CGH, LOH, and mutation analyses. Results We show by CGH that partial chromosomal losses in the initial tumors may not be present in the recurring tumors, by LOH that different haplotypes may be lost and that detected regions of LOH may be smaller in recurring tumors, and that mutations present in the initial tumor may not be present in the recurring ones. In contrast we show that despite apparent genomic differences, the recurrent and multiple bladder tumors from the same patients display remarkably similar expression profiles. Conclusion Our findings show that even though the vast majority of the analyzed meta- and synchronous tumors from the same patients are not likely to have originated directly from the preceding tumor they still show remarkably similar expressions profiles. The presented data suggests that an expression profile is established early in tumor development and that this profile is stable and maintained in recurring tumors.

  13. The use of computerized tomography in patients showing tardive dyskinesia

    29 patients showing moderate to markedly pronounced tardive dyskinesia (TD) and a further 29 control patients (C) under a similar long-term medication with neuroleptics that had been so chosen as to match the age and sex distributions of the former group were subjected to computered tomography, neurological examination and psychological testing. The results did not point to any correlations between the structural changes and duration of treatment and the clinical signs or symptoms of extrapyramidal disorder. This was taken as further evidence in support of the theory that the initial damage in tardive dyskinesia mainly is at the level of the basal ganglia. (orig./MG)

  14. Tests show how oil muds increase shale stability

    Salisbury, D.P. (O' Brien-Goins-Simpson and Associates, Houston, TX (US)); Deem, C.K. (Amoco Production Co., Tulsa, OK (USA))

    1990-10-01

    This article describes the problems and processes involved in preserving shale cores at a rig site and testing the shale on the downhole simulation cell (DSC) with an oil mud. Data on the composition of the shale as determined by x-ray diffraction, thin section analysis and atomic absorption are presented. Results of three DSC tests are given showing how the shale in the region around the wellbore can be affected by oil mud. This article discusses the development of procedures and presents part of the baseline data for the comparison of the performance of water based systems.

  15. Tests show how oil muds increase shale stability

    This article describes the problems and processes involved in preserving shale cores at a rig site and testing the shale on the downhole simulation cell (DSC) with an oil mud. Data on the composition of the shale as determined by x-ray diffraction, thin section analysis and atomic absorption are presented. Results of three DSC tests are given showing how the shale in the region around the wellbore can be affected by oil mud. This article discusses the development of procedures and presents part of the baseline data for the comparison of the performance of water based systems

  16. Ganil results

    Recent Ganil results are presented: hot nuclei properties and multifragmentation, study of flow change around the inversion energy. Mesons and hard photons production are also briefly discussed. Correlations with studies that have been led in Saturne energy range, and the developments that can be foreseen in the future have been discussed

  17. SUMOylated IRF-1 shows oncogenic potential by mimicking IRF-2

    Interferon regulatory factor-1 (IRF-1) is an interferon-induced transcriptional activator that suppresses tumors by impeding cell proliferation. Recently, we demonstrated that the level of SUMOylated IRF-1 is elevated in tumor cells, and that SUMOylation of IRF-1 attenuates its tumor-suppressive function. Here we report that SUMOylated IRF-1 mimics IRF-2, an antagonistic repressor, and shows oncogenic potential. To demonstrate the role of SUMOylated IRF-1 in tumorigenesis, we used SUMO-IRF-1 recombinant protein. Stable expression of SUMO-IRF-1 in NIH3T3 cells resulted in focus formation and anchorage-independent growth in soft agar. Inoculation of SUMO-IRF-1-transfected cells into athymic nude mice resulted in tumor formation and infiltration of adipose tissues. Finally, we demonstrated that SUMO-IRF-1 transforms NIH3T3 cells in a dose-dependent manner suggesting that SUMOylated IRF-1 may act as an oncogenic protein in tumor cells.

  18. GAMS results

    The author emphasizes results of the GAMS Collaboration related to various subjects which have been approached during the last one and a half day. Five Institutes are involved in the GAMS Collaboration: IISN, IHEP, INFN, LAPP, LANL which are exploiting two experimental setups: one at IHEP (Serpukhov), known as GAMS-2000, the second at CERN (NA12 experiment), known as GAMS-4000. The results presented have mainly been obtained in the study of the exclusive reaction π-p → M0n where M0 decays finally into mγ where m can reach a value as large as 12. Four topics are presented: η decays, η' decays, f0 (1590), first evidence for an exotic meson in the ηπ0 channel

  19. New World cattle show ancestry from multiple independent domestication events.

    McTavish, Emily Jane; Decker, Jared E; Schnabel, Robert D; Taylor, Jeremy F; Hillis, David M

    2013-04-01

    Previous archeological and genetic research has shown that modern cattle breeds are descended from multiple independent domestication events of the wild aurochs (Bos primigenius) ∼10,000 y ago. Two primary areas of domestication in the Middle East/Europe and the Indian subcontinent resulted in taurine and indicine lines of cattle, respectively. American descendants of cattle brought by European explorers to the New World beginning in 1493 generally have been considered to belong to the taurine lineage. Our analyses of 47,506 single nucleotide polymorphisms show that these New World cattle breeds, as well as many related breeds of cattle in southern Europe, actually exhibit ancestry from both the taurine and indicine lineages. In this study, we show that, although European cattle are largely descended from the taurine lineage, gene flow from African cattle (partially of indicine origin) contributed substantial genomic components to both southern European cattle breeds and their New World descendants. New World cattle breeds, such as Texas Longhorns, provide an opportunity to study global population structure and domestication in cattle. Following their introduction into the Americas in the late 1400s, semiferal herds of cattle underwent between 80 and 200 generations of predominantly natural selection, as opposed to the human-mediated artificial selection of Old World breeding programs. Our analyses of global cattle breed population history show that the hybrid ancestry of New World breeds contributed genetic variation that likely facilitated the adaptation of these breeds to a novel environment. PMID:23530234

  20. Radon in Austrian tourist mines and show caves

    The radon situation in tourist mines and show caves is barely investigated in Austria. This paper investigates the influence of its determining factors, such as climate, structure and geology. For this purpose, long-term time-resolved measurements over 6 to 12 months in 4 tourist mines and 2 show caves - with 5 to 9 measuring points each - have been carried out to obtain the course of radon concentration throughout the year. In addition, temperature and air-pressure were measured and compared to the data outside where available. Results suggest that the dominating factors of the average radon concentration are structure and location (geology) of the tunnel-system, whereas the diurnal and annual variation is mainly caused by the changing airflow, which is driven by the difference in temperature inside and outside. Downcast air is connected with very low radon concentrations, upcast air with high concentrations. In some locations the maximum values appear when the airflow ceases. But airflow can be different in different parts of mines and caves. Systems close to the surface show generally lower radon levels than the ones located deeper underground. Due to variation of structure, geology and local climate, the radon situation in mines and caves can only be described by simultaneous measurements at several measuring points. (orig.)

  1. SAGE results

    The Russian-American Gallium solar neutrino Experiment (SAGE) is described. The solar neutrino flux measured by 31 extractions through October, 1993 is presented. The result of 69+/-10(stat)+5/-7(syst) SNU is to be compared with a Standard Solar Model prediction of 132 SNU. The initial results of a measurement of experimental efficiencies are also discussed by exposing the gallium target to neutrinos from an artificial source. The capture rate of neutrinos from this source is very close to that which is expected. The result can be expressed as a ratio of the measured capture rate to the anticipated rate from the source activity. This ratio is 0.93+0.15, -0.17 where the systematic and statistical errors have been combined. To first order the experimental efficiencies are in agreement with those determined during solar neutrino measurements and in previous auxiliary measurements. One must conclude that the discrepancy between the measured solar neutrino flux and that predicted by the solar models can not arise from an experimental artifact. (author)

  2. Double polymer sheathed carbon nanotube supercapacitors show enhanced cycling stability

    Zhao, Wenqi; Wang, Shanshan; Wang, Chunhui; Wu, Shiting; Xu, Wenjing; Zou, Mingchu; Ouyang, An; Cao, Anyuan; Li, Yibin

    2015-12-01

    Pseudo-materials are effective in boosting the specific capacitance of supercapacitors, but during service their degradation may also be very strong, causing reduced cycling stability. Here, we show that a carbon nanotube sponge grafted by two conventional pseudo-polymer layers in sequence can serve as a porous supercapacitor electrode with significantly enhanced cycling stability compared with single polymer grafting. Creating conformal polymer coatings on the nanotube surface and the resulting double-sheath configuration are important structural factors leading to the enhanced performance. Combining different polymers as double sheaths as reported here might be a potential route to circumvent the dilemma of pseudo-materials, and to simultaneously improve the capacitance and stability for various energy storage devices.Pseudo-materials are effective in boosting the specific capacitance of supercapacitors, but during service their degradation may also be very strong, causing reduced cycling stability. Here, we show that a carbon nanotube sponge grafted by two conventional pseudo-polymer layers in sequence can serve as a porous supercapacitor electrode with significantly enhanced cycling stability compared with single polymer grafting. Creating conformal polymer coatings on the nanotube surface and the resulting double-sheath configuration are important structural factors leading to the enhanced performance. Combining different polymers as double sheaths as reported here might be a potential route to circumvent the dilemma of pseudo-materials, and to simultaneously improve the capacitance and stability for various energy storage devices. Electronic supplementary information (ESI) available. See DOI: 10.1039/c5nr05978j

  3. Dogs show left facial lateralization upon reunion with their owners.

    Nagasawa, Miho; Kawai, Emi; Mogi, Kazutaka; Kikusui, Takefumi

    2013-09-01

    Domestic dogs demonstrate behavioral laterality in response to emotional stimuli; those responses include tail wagging and head turning. The dog is the species with the closest relationship to humans; dogs can express strong social emotions (e.g., attachment and separation anxiety) to specific persons, such as their owners. In this study, we examined whether dogs demonstrate more facial laterality when reunited with their owners than when they encounter an unfamiliar person in an unfamiliar situation. We also examined whether the observed laterality was specific to positive social stimuli (i.e., the owner) or a general response to nonsocial positive stimuli (i.e., toys). The dogs' facial expressions were recorded by a high-speed video camera during the presentation of emotional stimuli and the acceleration rates of parts of their faces were analyzed. The results showed that the left eyebrow moved more when the owner was present than at baseline. No bias in terms of eyebrow movement was observed when the dogs saw attractive toys. These results suggest that dogs show facial laterality in response to emotional stimuli. This laterality was specific to social stimuli, probably reflecting the dog's attachment to the owner. PMID:23727034

  4. Phytoceramide Shows Neuroprotection and Ameliorates Scopolamine-Induced Memory Impairment

    Seikwan Oh

    2011-10-01

    Full Text Available The function and the role phytoceramide (PCER and phytosphingosine (PSO in the central nervous system has not been well studied. This study was aimed at investigating the possible roles of PCER and PSO in glutamate-induced neurotoxicity in cultured neuronal cells and memory function in mice. Phytoceramide showed neuro-protective activity in the glutamate-induced toxicity in cultured cortical neuronal cells. Neither phytosphingosine nor tetraacetylphytosphingosine (TAPS showed neuroproective effects in neuronal cells. PCER (50 mg/kg, p.o. recovered the scopolamine-induced reduction in step-through latency in the passive avoidance test; however, PSO did not modulate memory function on this task. The ameliorating effects of PCER on spatial memory were confirmed by the Morris water maze test. In conclusion, through behavioral and neurochemical experimental results, it was demonstrated that central administration of PCER produces amelioration of memory impairment. These results suggest that PCER plays an important role in neuroprotection and memory enhancement and PCER could be a potential new therapeutic agent for the treatment of neurodegenerative diseases such as Alzheimer’s disease.

  5. Tevatron results

    Lefevre, R.; /Barcelona, Autonoma U.

    2005-01-01

    Recent results obtained by the CDF and D0 experiments at the Tevatron Run II are presented. A first part is dedicated to QCD physics where inclusive jet production, dijet azimuthal decorrelations and jet shapes measurements are reported. Electroweak physics is then discussed relating measurements of the W and Z bosons productions, of the forward-backward charge asymmetry in W production, of the W width and of the top quarks mass. The extensive Run II exploration program is finally approached reporting about searches for neutral supersymmetric Higgs bosons in multijet events and for sbottom quark from gluino decays.

  6. Human resistin, a proinflammatory cytokine, shows chaperone-like activity.

    Suragani, Madhuri; Aadinarayana, Varma D; Pinjari, Aleem Basha; Tanneeru, Karunakar; Guruprasad, Lalitha; Banerjee, Sharmistha; Pandey, Saurabh; Chaudhuri, Tapan K; Ehtesham, Nasreen Zafar

    2013-12-17

    Resistin, a cysteine-rich adipocytokine, proposed as a link between obesity and diabetes in mice, was shown as a proinflammatory molecule in humans. We earlier reported that human resistin (hRes), a trimer, was resistant to heat and urea denaturation, existed in an oligomeric polydispersed state, and showed a concentration-dependent conformational change. These properties and an intimate correlation of hRes expression with cellular stress prompted us to investigate hRes as a possible chaperone. Here, we show that recombinant human resistin was able to protect the heat-labile enzymes citrate synthase and Nde1 from thermal aggregation and inactivation and was able to refold and restore their enzymatic activities after heat/guanidinium chloride denaturation. Furthermore, recombinant human resistin could bind misfolded proteins only. Molecular dynamics-based association-dissociation kinetics of hRes subunits pointed to resistin being a molecular chaperone. Bis-ANS, which blocks surface hydrophobicity, abrogated the chaperone activity of hRes, establishing the importance of surface hydrophobicity for chaperone activity. Replacement of Phe49 with Tyr (F49YhRes), a critical residue within the hydrophobic patch of hRes, although it could prevent thermal aggregation of citrate synthase and Nde1, was unable to refold and restore their activities. Treatment of U937 cells with tunicamycin/thapsigargin resulted in reduced hRes secretion and concomitant localization in the endoplasmic reticulum. Escherichia coli transformants expressing hRes could be rescued from thermal stress, pointing to hRes's chaperone-like function in vivo. HeLa cells transfected with hRes showed protection from thapsigargin-induced apoptosis. In conclusion, hRes, an inflammatory protein, additionally exhibited chaperone-like properties, suggesting a possible link between inflammation and cellular stress. PMID:24282299

  7. Nuclear opinion poll shows increasing expectations and anxiety

    The prime Minister's Office conducted a public opinion poll from March 1 to 7, 1984, in three areas: public recognition of nuclear energy, public recognition of nuclear power generation, and recognition of the safety of nuclear power generation. Public acceptance of nuclear power is essential for the smooth development of nuclear power generation. The interviewers met 2,252 people of total 3,000 selected by random sampling throughout the country. The results showed that the majority of the people recognize the necessity of developing oil-alternative energy, and hold expectation on the role and promotion of nuclear power as a main power source of future, but at the same time, they have some anxiety about the safety of nuclear power plants. (Mori, K.)

  8. Malignant melanoma showing a rapid response to nivolumab.

    Tsutsumi, Miho; Asai, Jun; Wada, Makoto; Takenaka, Hideya; Katoh, Norito

    2016-02-01

    Malignant melanoma is a highly aggressive skin tumour, with a recent rise in incidence. Nivolumab is a recently developed anti-programmed cell death-1 immune checkpoint inhibitor and its usage has resulted in a significant improvement in the overall survival of patients with metastatic melanomas. We report a case of advanced melanoma that showed a significant and rapid response to nivolumab treatment. The patient displayed multiple melanoma-associated vitiligo prior to treatment; this symptom was theorised to indicate potentially immunoreactive melanoma and the need for nivolumab. In addition, interferon-? was injected prior to nivolumab treatment. The significant rapid response to nivolumab suggested the induction of a marked immune response against melanoma by interferon-?. Therefore, interferon-? could be a useful and effective adjuvant for nivolumab therapy. PMID:25854419

  9. Female migraineurs show lack of insular thinning with age.

    Maleki, Nasim; Barmettler, Gabi; Moulton, Eric A; Scrivani, Steven; Veggeberg, Rosanna; Spierings, Egilius L H; Burstein, Rami; Becerra, Lino; Borsook, David

    2015-07-01

    Gray matter loss in cortical regions is a normal ageing process for the healthy brain. There have been few studies on the process of ageing of the brain in chronic neurological disorders. In this study, we evaluated changes in the cortical thickness by age in 92 female subjects (46 patients with migraine and 46 healthy controls) using high-field magnetic resonance imaging. The results indicate that in contrast to healthy subjects, migraineurs show a lack of thinning in the insula by age. The functional significance of the lack of thinning is unknown, but it may contribute to the overall cortical hyperexcitability of the migraine brain because the region is tightly involved in a number of major brain networks involved in interoception, salience, nociception, and autonomic function, including the default mode network. PMID:25775358

  10. Silver nanoparticles synthesised using plant extracts show strong antibacterial activity.

    Kumari, Avnesh; Guliani, Anika; Singla, Rubbel; Yadav, Ramdhan; Yadav, Sudesh Kumar

    2015-06-01

    In this study, three plants Populus alba, Hibiscus arboreus and Lantana camara were explored for the synthesis of silver nanoparticles (SNPs). The effect of reaction temperature and leaf extract (LE) concentration of P. alba, H. arboreus and L. camara was evaluated on the synthesis and size of SNPs. The SNPs were characterised by ultra-violet-visible spectroscopy, scanning electron microscopy and atomic force microscopy. The synthesis rate of SNPs was highest with LE of L. camara followed by H. arboreus and P. alba under similar conditions. L. camara LE showed maximum potential of smaller size SNPs synthesis, whereas bigger particles were formed by H. arboreous LE. The size and shape of L. camara LE synthesised SNPs were analysed by transmission electron microscopy (TEM) and energy dispersive X-ray spectroscopy (EDX). TEM analysis revealed the formation of SNPs of average size 17±9.5 nm with 5% LE of L. camara. The SNPs synthesised by LE of L. camara showed strong antibacterial activity against Escherichia coli. The results document that desired size SNPs can be synthesised using these plant LEs at a particular temperature for applications in the biomedical field. PMID:26023158

  11. A case of cerebral infarction showing interesting SPECT images

    A case of cerebral infarction showing interesting SPECT images was reported. One month after stroke, 81mKr and 99mTc-HMPAO-SPECT were showed post ischemic high flow area as hot lesion, but 123I-IMP-SPECT was showed as cold lesion in early scan. Two months after stroke, all SPECT images showed infarction as cold area. (author)

  12. Roadside soils show low plant available zinc and copper concentrations.

    Morse, Natalie; Walter, M Todd; Osmond, Deanna; Hunt, William

    2016-02-01

    Vehicle combustion and component wear are a major source of metal contamination in the environment, which could be especially concerning where road ditches are actively farmed. The objective of this study was to assess how site variables, namely age, traffic (vehicles day(-1)), and percent carbon (%C) affect metal accumulation in roadside soils. A soil chronosequence was established with sites ranging from 3 to 37 years old and bioavailable, or mobile, concentrations of Zinc (Zn) and Copper (Cu) were measured along major highways in North Carolina using a Mehlich III extraction. Mobile Zn and Cu concentrations were low overall, and when results were scaled via literature values to "total metal", the results were still generally lower than previous roadside studies. This could indicate farming on lands near roads would pose a low plant toxicity risk. Zinc and Cu were not correlated with annual average traffic count, but were positively correlated with lifetime traffic load (the product of site age and traffic count). This study shows an often overlooked variable, site age, should be included when considering roadside pollution accumulation. Zinc and Cu were more strongly associated with %C, than traffic load. Because vehicle combustion is also a carbon source, it is not obvious whether the metals and carbon are simply co-accumulating or whether the soil carbon in roadside soils may facilitate previously overlooked roles in sequestering metals on-site. PMID:26629643

  13. Slippery liquid-infused porous surfaces showing marine antibiofouling properties.

    Xiao, Linlin; Li, Junsheng; Mieszkin, Sophie; Di Fino, Alessio; Clare, Anthony S; Callow, Maureen E; Callow, James A; Grunze, Michael; Rosenhahn, Axel; Levkin, Pavel A

    2013-10-23

    Marine biofouling is a longstanding problem because of the constant challenges placed by various fouling species and increasingly restricted environmental regulations for antifouling coatings. Novel nonbiocidal strategies to control biofouling will necessitate a multifunctional approach to coating design. Here we show that slippery liquid-infused porous surfaces (SLIPSs) provide another possible strategy to obtaining promising antifouling coatings. Microporous butyl methacrylate-ethylene dimethacrylate (BMA-EDMA) surfaces are prepared via UV-initiated free-radical polymerization. Subsequent infusion of fluorocarbon lubricants (Krytox103, Krytox100, and Fluorinert FC-70) into the porous microtexture results in liquid-repellent slippery surfaces. To study the interaction with marine fouling organisms, settlement of zoospores of the alga Ulva linza and cypris larvae of the barnacle Balanus amphitrite is tested in laboratory assays. BMA-EDMA surfaces infused with Krytox103 and Krytox100 exhibit remarkable inhibition of settlement (attachment) of both spores and cyprids to a level comparable to that of a poly(ethylene glycol) (PEG)-terminated self-assembled monolayer. In addition, the adhesion strength of sporelings (young plants) of U. linza is reduced for BMA-EDMA surfaces infused with Krytox103 and Krytox100 compared to pristine (noninfused) BMA-EDMA and BMA-EDMA infused with Fluorinert FC-70. Immersion tests suggest a correlation between the stability of slippery coatings in artificial seawater and fouling resistance efficacy. The results indicate great potential for the application of this concept in fouling-resistant marine coatings. PMID:24067279

  14. Management in a neotropical show cave: planning for invertebrates conservation

    Thais Giovannini Pellegrini

    2012-07-01

    Full Text Available Lapa Nova is a dolomitic cave about 4.5 km long located in northwestern Minas Gerais state, Brazil. The cave experiences intense tourism, concentrated over a single period of the year, during the Feast of Our Lady of Lapa. In order to evaluate the impacts felt by the invertebrate community from this tourism, a new methodology was proposed. Four types of areas (intense visitation area, outlying visitation areas, moderate visitation areas and no-visitation areas were sampled for invertebrates. There was one sampling prior and another on the last day of the 128th feast, to evaluate the effects of visitation on cave-dwelling invertebrates. Results show that invertebrate populations residing in more intensely visited areas of the cave undergo changes in distribution following the event. As a consequence of tourism, invertebrates shift to outlying locations from the visited area, which serve as refuges to the communities. Apparently, the fact that there are places inside Lapa Nova inaccessible to tourists reduces the impact suffered by the invertebrate community, as those sites serve as refuges for cave-dwelling organisms during the pilgrimage. A proper management plan was devised for the tourism/religious use of the cave. It consists basically of delimiting marked pathways for tourists, allowing invertebrates to seek shelter at locations outside visited areas and keeping no-visitation areas off-limits to tourism based on the results of the visitation effects on cave-dwelling invertebrates.

  15. Advanced Ebola Is Riskiest Stage for Caregivers, Study Shows

    ... nih.gov/medlineplus/news/fullstory_155914.html Advanced Ebola Is Riskiest Stage for Caregivers, Study Shows Transmission ... 28,000 in three West African nations: Guinea, Liberia and Sierra Leone. The new findings show that ...

  16. Toroidal pores formed by antimicrobial peptides show significant disorder.

    Sengupta, Durba; Leontiadou, Hari; Mark, Alan E; Marrink, Siewert-Jan

    2008-10-01

    A large variety of antimicrobial peptides have been shown to act, at least in vitro, by poration of the lipid membrane. The nanometre size of these pores, however, complicates their structural characterization by experimental techniques. Here we use molecular dynamics simulations, to study the interaction of a specific class of antimicrobial peptides, melittin, with a dipalmitoylphosphatidylcholine bilayer in atomic detail. We show that transmembrane pores spontaneously form above a critical peptide to lipid ratio. The lipid molecules bend inwards to form a toroidally shaped pore but with only one or two peptides lining the pore. This is in strong contrast to the traditional models of toroidal pores in which the peptides are assumed to adopt a transmembrane orientation. We find that peptide aggregation, either prior or after binding to the membrane surface, is a prerequisite to pore formation. The presence of a stable helical secondary structure of the peptide, however is not. Furthermore, results obtained with modified peptides point to the importance of electrostatic interactions in the poration process. Removing the charges of the basic amino-acid residues of melittin prevents pore formation. It was also found that in the absence of counter ions pores not only form more rapidly but lead to membrane rupture. The rupture process occurs via a novel recursive poration pathway, which we coin the Droste mechanism. PMID:18602889

  17. Multilocus Phylogenetics Show High Intraspecific Variability within Fusarium avenaceum

    Tomasz Kulik

    2011-08-01

    Full Text Available Fusarium avenaceum is a common soil saprophyte and plant pathogen of a variety of hosts worldwide. This pathogen is often involved in the crown rot and head blight of cereals that affects grain yield and quality. F. avenaceum contaminates grain with enniatins more than any species, and they are often detected at the highest prevalence among fusarial toxins in certain geographic areas. We studied intraspecific variability ofF. avenaceum based on partial sequences of elongation factor-1 alpha, enniatin synthase, intergenic spacer of rDNA, arylamine N-acetyltransferase and RNA polymerase II data sets. The phylogenetic analyses incorporated a collection of 63 F. avenaceum isolates of various origin among which 41 were associated with wheat. Analyses of the multilocus sequence (MLS data indicated a high level of genetic variation within the isolates studied with no significant linkage disequilibrium. Correspondingly, maximum parsimony analyses of both MLS and individual data sets showed lack of clear phylogenetic structure withinF. avenaceum in relation to host (wheat and geographic origin. Lack of host specialization indicates no host selective pressure in driving F. avenaceum evolution, while no geographic lineage structure indicates widespread distribution of genotypes that resulted in nullifying the effects of geographic isolation on the evolution of this species. Moreover, significant incongruence between all individual tree topologies and little clonality is consistent with frequent recombination within F. avenaceum.

  18. Minifish shows high genetic variation in mtDNA size.

    Chen, X-W; Li, Q-L; Hu, X-J; Yuan, Y-M; Wen, M; Peng, L-Y; Liu, S-J; Hong, Y-H

    2014-01-01

    The genus Paedocypris is a newly described taxon of minifish species that are characterized by extensive chromosome evolution and one of the smallest known vertebrate nuclear genomes. Paedocypris features a tiny adult size, a short generation time, low fecundity and fragmented tropical habitats, which are factors that favor rapid speciation. Most recently, we have revealed that P. progenetica (Pp), the type species of the genus Paedocypris, has an unusual mtDNA bearing - within its D-loop - a tandem array of a 34-bp repeat sequence called the minifish repeat, which shows compromised replication efficiency in vitro. Here we report that Pp exhibits high genetic variation in mtDNA size. The efficiency of D-loop amplification was found to depend upon primers. Interestingly, Pp individuals of one and the same population differed drastically in mtDNA size resulting from varying copy numbers of the minifish repeat. We conclude that minifish has a high mutation rate and perhaps represents a rapidly evolving taxon of vertebrates. PMID:25470287

  19. Lactotripeptides Show No Effect on Human Blood Pressure: Results from a double-blind randomized controlled trial

    Engberink, M.F.; Schouten, E.G.; Kok, F. J.; Mierlo, L.A.J., van; Brouwer, I.A.; Geleijnse, J. M.

    2008-01-01

    Milk-derived peptides with ACE-inhibiting properties may have antihypertensive effects in humans. We conducted a randomized double-blind placebo-controlled trial to examine the blood pressure lowering potential of 2 ACE-inhibiting lactotripeptides, ie, Isoleucine-Proline-Proline and Valine-Proline-Proline. We included 135 Dutch subjects with elevated systolic blood pressure who were otherwise healthy and who received no current antihypertensive treatment. After a 2-week run-in period on place...

  20. Map showing locations of damaging landslides in Napa County, California, resulting from 1997-98 El Nino rainstorms

    Godt, Jonathan W.; Savage, William Z.; Wilson, Raymond C.

    1999-01-01

    Heavy rainfall associated with a strong El Nino caused over $150 million in landslide damage in the 10-county San Francisco Bay region during the winter and spring of 1998. A team of USGS scientists collected information on landslide locations and damage costs. Napa County was relatively unaffected in comparison to other counties in the region with approximately $1.1 million in damages assessed.

  1. Oilsands for the USA : while environmental groups ask for a shutdown, new study shows significant resulting economic benefits in America

    The United States is beginning to appreciate the value of having massive oil sands resources located in relatively close proximity to their northern border. This article discussed a recent study conducted by the Canadian Energy Research Institute (CERI) to assess the impact of Canada's oil sands development on the economy of the United States. The study forecasted that the demand for oil sands-related goods and services from American companies will continue to increase as the industry expands. The top national-level goods and services impacts will be derived from increases in manufacturing; finance; insurance; real estate; and professional, scientific, and technical services. Accommodation and food services in the United States will also benefit from the growth of the oil sands industry. The United States may not risk pushing ahead with strict carbon-cutting legislation targeting the oil sands when policy-makers consider the potential impacts of Canada selling its resources to China. 1 fig.

  2. Face facts: BD patients show impairments in emotion processing

    Tamsyn Elizabeth Van Rheenen

    2012-11-01

    Full Text Available BACKGROUND AND AIMS: Patients with Bipolar Disorder (BD have difficulty in processing emotions but the specificity or generalizability of deficits across emotions is less clear. Moreover, preliminary evidence indicates that BD samples require greater expressive intensity to correctly identify facial emotions yet there has been little examination of where the intensity threshold for interpreting emotional information actually differs from controls (e.g., Lembke and Ketter, 2002;Getz et al., 2003;Guyer et al., 2007;Vederman et al., 2011. To address these limitations we conducted two experiments to examine a the specificity of emotion labelling impairments and b facial emotion processing sensitivity in a BD sample. METHODS: 50 BD patients and 51 healthy controls completed a series of emotion processing tasks assessing emotion perception accuracy for the labeling and discrimination of static and dynamic facial emotions. All patients met criteria for a DSM-IV diagnosis of BD, with diagnoses confirmed with the Mini International Neuropsychiatric Interview. RESULTS: Results from experiment one indicated a 7.5 8.5% reduction in patients ability to recognize fear across both static and dynamic tasks. Results from experiment two indicated that patients performed worse than controls on emotion labeling overall, but there was no specific deficit at any given level of intensity other than for the labeling of fear (impaired at both high and medium intensity. The patient group did however show reduced emotion discrimination accuracy; while discrimination at 100% intensity was intact there was a ~5.74% reduction in accurately discriminating emotions at 75% intensity and a strong trend for a ~4.43% reduction in discrimination accuracy at 50% intensity. CONCLUSIONS: In addition to demonstrating subtle impairments for the discrimination of emotions at lower levels of intensity, BD patients are also impaired in their ability to recognize fear. This is evident across task types and differing stimulus intensity and may be linked to an inappropriate allocation of visual attention and/or reduced use of second order configural information.

  3. Optimizing the Natural Frequencies of Beams via Notch Stamping

    Nabeel T. Alshabatat

    2012-07-01

    Full Text Available Natural frequency optimization is important to avoid the coincidence of excitation frequency and natural frequency which causes resonance phenomenon. In this study, the natural frequencies of a beam, with different boundary conditions, are enhanced by stamping V-notches on its surface. These notches alter the local stiffness in the beam while keeping the mass the same. This method is cost-effective in comparison with other Structural Dynamics Modification methods (SDM because it is a one-step manufacturing method and because it enhances the dynamic behavior of beam structures without additional weight or additional joints. The natural frequencies of notched beam are calculated by finite element method. In particular, ANSYS package is used in building the notched beam models for modal analysis. The effect of notch location and size on the beam fundamental frequency is investigated. The simulation results indicated that creating notches on free-free beam decreases its fundamental frequency, while creating notches on clamped beam may increase its fundamental frequency. The optimal designs of notched beams are presented. The proposed method couples a finite element method for the modal analysis with an optimization technique based on Genetic Algorithm (GA. Three examples are presented to show the optimal design of free-free and clamped notched beams. The optimization results show that V-notch stamping technique is an effective technique to optimize the natural frequencies.

  4. Uudised : Otsman taas Riias show'l. Rokkstaarist ministriks

    2007-01-01

    Drag-kabareeartist Erkki Otsman esineb detsembris Riias "Sapnu Fabrikas" toimuval jõulu-show'l. Austraalia rokkansambli Midnight Oil endine laulja Peter Garrett nimetati valitsuse keskkonnaministriks

  5. Curcumin shows excellent therapeutic effect on psoriasis in mouse model.

    Kang, Di; Li, Bowen; Luo, Lei; Jiang, Wenbing; Lu, Qiumin; Rong, Mingqing; Lai, Ren

    2016-04-01

    Curcumin is an active herbal ingredient possessing surprisingly wide range of beneficial properties, including anti-inflammatory, antioxidant, chemopreventive and chemotherapeutic activity. Recently, it has been reported to exhibit inhibitory activity on potassium channel subtype Kv1.3. As Kv1.3 channels are mainly expressed in T cells and play a key role in psoriasis, the effects of curcumin were investigated on inflammatory factors secretion in T cells and psoriasis developed in keratin (K) 14-vascular endothelial growth factor (VEGF) transgenic mouse model. Results showed that, 10 μM of curcumin significantly inhibited secretion of inflammatory factors including interleukin (IL)-17,IL-22, IFN-γ, IL-2, IL-8 and TNF-α in T cells by 30-60% in vitro. Notably, more than 50% of T cells proliferation was inhibited by application of 100 μM curcumin. Compared with severe psoriatic symptoms observed in the negative control mice, all psoriasis indexes including ear redness, weight, thickness and lymph node weight were significantly improved by oral application of curcumin in treatment mouse group. Histological examination indicated that curcumin had anti-inflammatory function in the experimental animals. More than 50% level of inflammatory factors including TNF-α, IFN-γ, IL-2, IL-12, IL-22 and IL-23 in mouse serum was decreased by curcumin treatment as well as cyclosporine. Compared with renal fibrosis observed in the mouse group treated by cyclosporine, no obvious side effect in mouse kidney was found after treated by curcumin. Taken together, curcumin, with high efficacy and safety, has a great potential to treat psoriasis. PMID:26826458

  6. A novel nucleic acid analogue shows strong angiogenic activity

    Tsukamoto, Ikuko, E-mail: tukamoto@med.kagawa-u.ac.jp [Department of Pharmaco-Bio-Informatics, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki, Kita, Kagawa 761-0793 (Japan); Sakakibara, Norikazu; Maruyama, Tokumi [Kagawa School of Pharmaceutical Sciences, Tokushima Bunri University, 1314-1 Shido, Sanuki, Kagawa 769-2193 (Japan); Igarashi, Junsuke; Kosaka, Hiroaki [Department of Cardiovascular Physiology, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki, Kita, Kagawa 761-0793 (Japan); Kubota, Yasuo [Department of Dermatology, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki, Kita, Kagawa 761-0793 (Japan); Tokuda, Masaaki [Department of Cell Physiology, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki, Kita, Kagawa 761-0793 (Japan); Ashino, Hiromi [The Tokyo Metropolitan Institute of Medical Science, 1-6 Kamikitazawa2-chome, Setagaya-ku, Tokyo 156-8506 (Japan); Hattori, Kenichi; Tanaka, Shinji; Kawata, Mitsuhiro [Teikoku Seiyaku Co., Ltd., Sanbonmatsu, Higashikagawa, Kagawa 769-2695 (Japan); Konishi, Ryoji [Department of Pharmaco-Bio-Informatics, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki, Kita, Kagawa 761-0793 (Japan)

    2010-09-03

    Research highlights: {yields} A novel nucleic acid analogue (2Cl-C.OXT-A, m.w. 284) showed angiogenic potency. {yields} It stimulated the tube formation, proliferation and migration of HUVEC in vitro. {yields} 2Cl-C.OXT-A induced the activation of ERK1/2 and MEK in HUVEC. {yields} Angiogenic potency in vivo was confirmed in CAM assay and rabbit cornea assay. {yields} A synthesized small angiogenic agent would have great clinical therapeutic value. -- Abstract: A novel nucleic acid analogue (2Cl-C.OXT-A) significantly stimulated tube formation of human umbilical endothelial cells (HUVEC). Its maximum potency at 100 {mu}M was stronger than that of vascular endothelial growth factor (VEGF), a positive control. At this concentration, 2Cl-C.OXT-A moderately stimulated proliferation as well as migration of HUVEC. To gain mechanistic insights how 2Cl-C.OXT-A promotes angiogenic responses in HUVEC, we performed immunoblot analyses using phospho-specific antibodies as probes. 2Cl-C.OXT-A induced robust phosphorylation/activation of MAP kinase ERK1/2 and an upstream MAP kinase kinase MEK. Conversely, a MEK inhibitor PD98059 abolished ERK1/2 activation and tube formation both enhanced by 2Cl-C.OXT-A. In contrast, MAP kinase responses elicited by 2Cl-C.OXT-A were not inhibited by SU5416, a specific inhibitor of VEGF receptor tyrosine kinase. Collectively these results suggest that 2Cl-C.OXT-A-induces angiogenic responses in HUVEC mediated by a MAP kinase cascade comprising MEK and ERK1/2, but independently of VEGF receptor tyrosine kinase. In vivo assay using chicken chorioallantoic membrane (CAM) and rabbit cornea also suggested the angiogenic potency of 2Cl-C.OXT-A.

  7. The Presentation of Science in Everyday Life: The Science Show

    Watermeyer, Richard

    2013-01-01

    This paper constitutes a case-study of the "science show" model of public engagement employed by a company of science communicators focused on the popularization of science, technology, engineering and mathematics (STEM) subject disciplines with learner constituencies. It examines the potential of the science show to foster the interest

  8. 47 CFR 73.33 - Antenna systems; showing required.

    2010-10-01

    ... 47 Telecommunication 4 2010-10-01 2010-10-01 false Antenna systems; showing required. 73.33... RADIO BROADCAST SERVICES AM Broadcast Stations § 73.33 Antenna systems; showing required. (a) An application for authority to install a broadcast antenna shall specify a definite site and include...

  9. The Presentation of Science in Everyday Life: The Science Show

    Watermeyer, Richard

    2013-01-01

    This paper constitutes a case-study of the "science show" model of public engagement employed by a company of science communicators focused on the popularization of science, technology, engineering and mathematics (STEM) subject disciplines with learner constituencies. It examines the potential of the science show to foster the interest…

  10. 47 CFR 74.131 - Licensing requirements, necessary showing.

    2010-10-01

    ... 47 Telecommunication 4 2010-10-01 2010-10-01 false Licensing requirements, necessary showing. 74.131 Section 74.131 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) BROADCAST RADIO... Experimental Broadcast Stations § 74.131 Licensing requirements, necessary showing. (a) An applicant for a...

  11. Exhibition at The International Surface Design Show London 2014

    Harris, J M

    2014-01-01

    The 2014 Surface Design Show is an international trade show for innovative surfaces for the interiors and architectural industries.Enterprise and Innovation was key to this year’s exhibition curated by Senior Lecturer Joanne Harris. The theme of the stand was titled "Making it Real” and showcased early stage product prototypes for the Surface Design and Textile industries.

  12. 36 CFR 14.24 - Showing as to citizenship required.

    2010-07-01

    ... (26 Stat. 1101; 43 U.S.C. 946 et seq.), and the Act of January 13, 1897 (29 Stat. 484; 43 U.S.C. 952... marital status is not required. In other cases, a married woman or widow must show the date of her... INTERIOR RIGHTS-OF-WAY Procedures 14.24 Showing as to citizenship required. (a) Individuals....

  13. ShowFlow: A practical interface for groundwater modeling

    Tauxe, J.D.

    1990-12-01

    ShowFlow was created to provide a user-friendly, intuitive environment for researchers and students who use computer modeling software. What traditionally has been a workplace available only to those familiar with command-line based computer systems is now within reach of almost anyone interested in the subject of modeling. In the case of this edition of ShowFlow, the user can easily experiment with simulations using the steady state gaussian plume groundwater pollutant transport model SSGPLUME, though ShowFlow can be rewritten to provide a similar interface for any computer model. Included in this thesis is all the source code for both the ShowFlow application for Microsoft{reg sign} Windows{trademark} and the SSGPLUME model, a User's Guide, and a Developer's Guide for converting ShowFlow to run other model programs. 18 refs., 13 figs.

  14. A Metallurgical Evaluation of the Powder-Bed Laser Additive Manufactured 4140 Steel Material

    Wang, Wesley; Kelly, Shawn

    2016-03-01

    Using laser powder bed fusion (PBF-L) additive manufacturing (AM) process for steel or iron powder has been attempted for decades. This work used a medium carbon steel (AISI 4140) powder to explore the feasibility of AM. The high carbon equivalent of 4140 steel (CEIIW ≈ 0.83) has a strong tendency toward cold cracking. As such, the process parameters must be carefully controlled to ensure the AM build quality. Through an orthogonally designed experimental matrix, a laser-welding procedure was successfully developed to produce 4140 steel AM builds with no welding defects. In addition, the microstructure and micro-cleanliness of the as-welded PBF-L AM builds were also examined. The results showed an ultra-fine martensite lath structure and an ultra-clean internal quality with minimal oxide inclusion distribution. After optimizing the PBF-L AM process parameters, including the laser power and scan speed, the as-welded AM builds yielded an average tensile strength higher than 1482 MPa and an average 33 J Charpy V-notch impact toughness at -18°C. The surface quality, tensile strength, and Charpy V-notch impact toughness of AM builds were comparable to the wrought 4140 steel. The excellent mechanical properties of 4140 steel builds created by the PBF-L AM AM process make industrial production more feasible, which shows great potential for application in the aerospace, automobile, and machinery industries.

  15. A Metallurgical Evaluation of the Powder-Bed Laser Additive Manufactured 4140 Steel Material

    Wang, Wesley; Kelly, Shawn

    2016-01-01

    Using laser powder bed fusion (PBF-L) additive manufacturing (AM) process for steel or iron powder has been attempted for decades. This work used a medium carbon steel (AISI 4140) powder to explore the feasibility of AM. The high carbon equivalent of 4140 steel (CEIIW ? 0.83) has a strong tendency toward cold cracking. As such, the process parameters must be carefully controlled to ensure the AM build quality. Through an orthogonally designed experimental matrix, a laser-welding procedure was successfully developed to produce 4140 steel AM builds with no welding defects. In addition, the microstructure and micro-cleanliness of the as-welded PBF-L AM builds were also examined. The results showed an ultra-fine martensite lath structure and an ultra-clean internal quality with minimal oxide inclusion distribution. After optimizing the PBF-L AM process parameters, including the laser power and scan speed, the as-welded AM builds yielded an average tensile strength higher than 1482 MPa and an average 33 J Charpy V-notch impact toughness at -18C. The surface quality, tensile strength, and Charpy V-notch impact toughness of AM builds were comparable to the wrought 4140 steel. The excellent mechanical properties of 4140 steel builds created by the PBF-L AM AM process make industrial production more feasible, which shows great potential for application in the aerospace, automobile, and machinery industries.

  16. X-31 Unloading Returning from Paris Air Show

    1995-01-01

    After being flown in the Paris Air Show in June 1995, the X-31 Enhanced Fighter Maneuverability Technology Demonstrator Aircraft, based at the NASA Dryden Flight Research Center, Edwards Air Force Base, California, is off-loaded from an Air Force Reserve C-5 transport after the ferry flight back to Edwards. At the air show, the X-31 demonstrated the value of using thrust vectoring (directing engine exhaust flow) coupled with advanced flight control systems to provide controlled flight at very high angles of attack. The X-31 Enhanced Fighter Maneuverability (EFM) demonstrator flew at the Ames- Dryden Flight Research Facility, Edwards, California (redesignated the Dryden Flight Research Center in 1994) from February 1992 until 1995 and before that at the Air Force's Plant 42 in Palmdale, California. The goal of the project was to provide design information for the next generation of highly maneuverable fighter aircraft. This program demonstrated the value of using thrust vectoring (directing engine exhaust flow) coupled with an advanced flight control system to provide controlled flight to very high angles of attack. The result was a significant advantage over most conventional fighters in close-in combat situations. The X-31 flight program focused on agile flight within the post-stall regime, producing technical data to give aircraft designers a better understanding of aerodynamics, effectiveness of flight controls and thrust vectoring, and airflow phenomena at high angles of attack. Stall is a condition of an airplane or an airfoil in which lift decreases and drag increases due to the separation of airflow. Thrust vectoring compensates for the loss of control through normal aerodynamic surfaces that occurs during a stall. Post-stall refers to flying beyond the normal stall angle of attack, which in the X-31 was at a 30-degree angle of attack. During Dryden flight testing, the X-31 aircraft established several milestones. On November 6, 1992, the X-31 achieved controlled flight at a 70-degree angle of attack. On April 29, 1993, the second X-31 successfully executed a rapid minimum-radius, 180-degree turn using a post-stall maneuver, flying well beyond the aerodynamic limits of any conventional aircraft. This revolutionary maneuver has been called the 'Herbst Maneuver' after Wolfgang Herbst, a German proponent of using post-stall flight in air-to-air combat. It is also called a 'J Turn' when flown to an arbitrary heading change. The aircraft was flown in tactical maneuvers against an F/A-18 and other tactical aircraft as part of the test flight program. During November and December 1993, the X-31 reached a supersonic speed of Mach 1.28. In 1994, the X-31 program installed software to demonstrate quasi-tailless operation. The X-31 flight test program was conducted by an international test organization (ITO) managed by the Advanced Research Projects Office (ARPA), known as the Defense Advanced Research Projects Office (DARPA) before March 1993. The ITO included the U.S. Navy and U.S. Air Force, Rockwell Aerospace, the Federal Republic of Germany, Daimler-Benz (formerly Messerschmitt-Bolkow-Blohm and Deutsche Aerospace), and NASA. Gary Trippensee was the ITO director and NASA Project Manager. Pilots came from participating organizations. The X-31 was 43.33 feet long with a wingspan of 23.83 feet. It was powered by a single General Electric P404-GE-400 turbofan engine that produced 16,000 pounds of thrust in afterburner.

  17. QLab 3 show control projects for live performances & installations

    Hopgood, Jeromy

    2013-01-01

    Used from Broadway to Britain's West End, QLab software is the tool of choice for many of the world's most prominent sound, projection, and integrated media designers. QLab 3 Show Control: Projects for Live Performances & Installations is a project-based book on QLab software covering sound, video, and show control. With information on both sound and video system basics and the more advanced functions of QLab such as MIDI show control, new OSC capabilities, networking, video effects, and microphone integration, each chapter's specific projects will allow you to learn the software's capabilitie

  18. Implanted Lung Valves Show Promise in Some Emphysema Patients

    ... gov/medlineplus/news/fullstory_156135.html Implanted Lung Valves Show Promise in Some Emphysema Patients Study finds ... patients could help improve the success rate of valves implanted into the lungs of people with emphysema. ...

  19. Laser Unlocks Blood-Brain Barrier for Chemotherapy, Study Shows

    ... nlm.nih.gov/medlineplus/news/fullstory_157444.html Laser Unlocks Blood-Brain Barrier for Chemotherapy, Study Shows ... 24, 2016 WEDNESDAY, Feb. 24, 2016 (HealthDay News) -- Laser surgery can open the protective blood-brain barrier, ...

  20. Gene Therapy Shows Early Promise Against Heart Failure

    ... nlm.nih.gov/medlineplus/news/fullstory_158046.html Gene Therapy Shows Early Promise Against Heart Failure Inserting ... who suffer from heart failure: A trial using gene therapy appears to have boosted patients' cardiac function. " ...

  1. Salivary Gland Biopsy Shows Promise to Helping to Diagnose Parkinson's

    ... alike — in PDF's new scientific journal. Browse Now Parkinson's HelpLine Learn More Science News Salivary Gland Biopsy Shows Promise to Helping to Diagnose Parkinson’s - Mar 20 2014 A simple outpatient procedure that ...

  2. Penis Reconstructions 'Life-Altering' for Men, Studies Show

    ... nlm.nih.gov/medlineplus/news/fullstory_158725.html Penis Reconstructions 'Life-Altering' for Men, Studies Show Both ... Men who undergo surgery to create a new penis seem to fare well in the long term, ...

  3. Flu Hits Poor Neighborhoods the Hardest, Study Shows

    ... nlm.nih.gov/medlineplus/news/fullstory_157200.html Flu Hits Poor Neighborhoods the Hardest, Study Shows Low ... more likely to be hospitalized with complications from flu than wealthier people, a new study finds. Low ...

  4. Effective Marketing Strategies to Attract Business Visitors at Trade Shows

    Mei-Chin Chu; Sui-Ming Chiu

    2013-01-01

    Trade shows have been the focus of recent research as constituting one of the most effective marketing strategies.Related issues have been discussed extensively in the literature. How to achieve better performance is central tothese discussions. Studies on the key factors that influence trade show performance have focused mainly onsubjective opinions from the perspective of the staff at exhibitions. In this study, we explored the key criteria fora business visitor in selecting suppliers at a ...

  5. The Effectiveness of Trade Shows in Global Competition

    JONIDA KELLEZI

    2013-06-01

    Full Text Available Trade shows industry has experienced a rapid growth during the last years. They are considered as a vital communication technique especially for those companies that operate in international markets and that aim to reach specific audiences. Making them an integral part of the marketing communication strategy enables companies in: developing customer relationships; offering possibilities for sales and sales promotion; undertaking and maintaining good international business relations; monitoring international competition as well as minimizing entry barriers in new markets. During the last years, many Albanian companies that operate in foreign businesses have started to engage in trade shows. Face to face meetings with their potential customers and direct competitors are among the most important reasons for investing in this marketing tool. Even though the literature regarding trade shows effectiveness is increasing constantly, research on its effectiveness is still limited. Therefore, the aim of this paper is to study the effectiveness of trade shows as a marketing communication tool. More specifically, it is focused in studying the usage of trade shows by Albanian companies when competing on international markets.

  6. Five Kepler target stars that show multiple transiting exoplanet candidates

    Steffen, Jason H; Borucki, William J; Buchhave, Lars A; Caldwell, Douglas A; Cochran, William D; Endl, Michael; Fabrycky, Daniel C; Fressin, Franois; Ford, Eric B; Fortney, Jonathan J; Haas, Michael J; Holman, Matthew J; Isaacson, Howard; Jenkins, Jon M; Koch, David; Latham, David W; Lissauer, Jack J; Moorhead, Althea V; Morehead, Robert C; Marcy, Geoffrey; MacQueen, Phillip J; Quinn, Samuel N; Ragozzine, Darin; Rowe, Jason F; Sasselov, Dimitar D; Seager, Sara; Torres, Guillermo; Welsh, William F

    2010-01-01

    We present and discuss five candidate exoplanetary systems identified with the Kepler spacecraft. These five systems show transits from multiple exoplanet candidates. Should these objects prove to be planetary in nature, then these five systems open new opportunities for the field of exoplanets and provide new insights into the formation and dynamical evolution of planetary systems. We discuss the methods used to identify multiple transiting objects from the Kepler photometry as well as the false-positive rejection methods that have been applied to these data. One system shows transits from three distinct objects while the remaining four systems show transits from two objects. Three systems have planet candidates that are near mean motion commensurabilities - two near 2:1 and one just outside 5:2. We discuss the implications that multitransiting systems have on the distribution of orbital inclinations in planetary systems, and hence their dynamical histories; as well as their likely masses and chemical compos...

  7. Uni Dufour | Ig Nobel Show with Marc Abrahams | 7 May

    2013-01-01

    On 7 May, Marc Abrahams, founder of the Ig Nobel Prize, will give an "Ig Nobel show", in English at Uni Dufour. The Ig Nobel Prizes are an American parody of the Nobel Prizes. In early October of each year, they are awarded to ten unusual or trivial achievements in scientific research. The stated aim of the prizes is to "first make people laugh, and then make them think". Marc Abrahams will introduce this funny and dynamic evening with a short presentation before handing over to a selection of recipients. The show is free and open to all. Tuesday 7 May Ig Nobel Show 6:30 p.m. - Room U600 Uni Dufour

  8. Five kepler target stars that show multiple transiting exoplanet candidates

    Steffen..[], Jason H.; Batalha, N. M.; Broucki, W J.; Buchhave, Lars C. Astrup

    2010-01-01

    We present and discuss five candidate exoplanetary systems identified with the Kepler spacecraft. These five systems show transits from multiple exoplanet candidates. Should these objects prove to be planetary in nature, then these five systems open new opportunities for the field of exoplanets and...... provide new insights into the formation and dynamical evolution of planetary systems. We discuss the methods used to identify multiple transiting objects from the Kepler photometry as well as the false-positive rejection methods that have been applied to these data. One system shows transits from three...

  9. CERN cars drive by the Geneva Motor Show

    CERN Bulletin

    2011-01-01

    One of CERN's new gas-fuelled cars was a special guest at the press days of the Geneva motor show this year. The car enjoyed a prominent position on the Gazmobil stand, right next to the latest Mazeratis and Ferraris. Journalists previewing the motor show could discover CERN's support for green technologies and also find out more about the lab - home to the fastest racetrack on the planet, with protons in the LHC running at 99.9999991% of the speed of light.    

  10. [A case of multilocular renal cyst showing neoplastic features].

    Morizumi, H; Aga, Y; Akiyama, M; Kan, S; Yano, M

    A 45-year-old woman was hospitalized with complaint of upper right abdominal pain. By serial examination, it was difficult to distinguish renal cyst from renal cancer. But, because of the frequency of the attacks of upper abdominal pain, nephrectomy was undertaken. The tumor measured 5 X 5 X 3 cm, was distinct from normal renal tissue, and consisted of a small cyst. Histologically, we diagnosed a multilocular renal cyst, and its lining cells showed small atypia and adenomatous proliferation. We concluded that this multilocular renal cyst showed neoplastic features. PMID:4032766

  11. The Biochemistry Show: a new and fun tool for learning

    A.H Ono

    2006-07-01

    Full Text Available The traditional methods to teach biochemistry in most universities are based on the memorization of chemical structures,  biochemical  pathways  and  reagent  names,  which  is  many  times  dismotivating  for  the  students.  We presently describe an innovative, interactive and alternative method for teaching biochemistry to medical and nutrition undergraduate students, called the Biochemistry Show (BioBio Show.The Biobio show is based on active participation of the students. They are divided in groups and the groups face each other. One group faces another one group at a time, in a game based on true or false questions that involve subjects of applied biochemistry (exercise, obesity, diabetes, cholesterol, free radicals, among others. The questions of the Show are previously elaborated by senior students. The Biobio Show has four phases, the first one is a selection exam, and from the second to the fourth phase, eliminatory confrontations happen. On a confrontation, the first group must select a certain quantity of questions for the opponent to answer.  The group who choses the questions must know how to answer and justify the selected questions. This procedure is repeated on all phases of the show. On the last phase, the questions used are taken from an exam previously performed by the students: either the 9-hour biochemistry exam (Sé et al. A 9-hour biochemistry exam. An iron man competition or a good way of evaluating undergraduate students? SBBq 2005, abstract K-6 or the True-or-False exam (TFE (Sé et al. Are tutor-students capable of writing good biochemistry exams? SBBq 2004, abstract K-18. The winner group receives an extra 0,5 point on the final grade. Over 70% of the students informed on a questionnaire that the Biobio Show is a valuable tool for learning biochemistry.    That is a new way to enrich the discussion of biochemistry in the classroom without the students getting bored. Moreover, learning is powered by critical and applied biochemistry emphasis during the Biobio Show. Financial Support: CNPq and PIBIC.

  12. Take-away shows & indie : autentisitetskonstruksjoner i et online musikkvideoprosjekt

    2010-01-01

    Denne oppgaven tar for seg det nettdistribuerte videoprosjektet Take-Away Shows, og dets forbindelser til indiesjangeren. Take-Away Shows er et pågående prosjekt der band og artister inviteres til å framføre musikken sin akustisk og “live” foran kamera, i andre settinger enn konsertscenen. Indie undersøkes langs debatter om uavhengighet, autentisitet, og DIY(“do-it-yourself”)-kultur, samt gjennom å diskutere indie som kontemporær musikksjanger med et omliggende kulturelt verdisett. Take-Away ...

  13. Static and impact crack properties of a high-strength steel welded joint

    In order to gain the benefits of weldable high-strength steels in pressurized equipment applications, satisfactory toughness and crack properties of the welded joint, both in the weld metal and the heat-affected -zone (HAZ), are required. Experimental investigations of toughness and crack resistance parameters through static and impact tests of a high-strength, low-alloy steel (HSLA) with a nominal yield strength of 700 MPa and its welded joint, were performed on Charpy-sized specimens, V-notched and pre-cracked, of the parent metal, weld metal and HAZ. The selected electrode produced slight undermatching and enabled the welded joints to be manufactured without cold cracks. The impact energy and its parts responsible for crack initiation and propagation were determined by toughness evaluation. Crack sensitivity, defined as the ratio of the impact energy for V-notched and for pre-cracked specimens, enabled a comparison of the homogeneous microstructure of the parent metal and the weld metal, and of the heterogeneous microstructure of the heat-affected-zone (HAZ), which indicated a better crack toughness behaviour of the HAZ. The results obtained showed that the toughness and crack resistance of the weld metal were significantly lower than those of the parent metal and the HAZ. The fracture mechanics parameters, J Ic integral, and plane strain fracture toughness, K Ic, as well as J resistance curves expressed the degradation less

  14. Analysis and tests of TF magnet insulation samples for the JET upgrade to 4 tesla

    Miele, P; Bettinali, L; Kaye, A; Last, J; Papastergiou, S; Riccardo, V; Visca, E

    2000-01-01

    The JET Toroidal Field (TF) coils were originally designed for operation at 3.4 tesla. In order to upgrade the field to 4 tesla and thus improve the performance of the JET machine, new mechanical tests and analysis were carried out on the insulation of TF coil samples. They are aimed at investigating the mechanical properties and the status of the insulation in order to set allowable stresses and force limits. In particular since the shear stress in the insulation is strongly affected by the shear modulus of elasticity G, it is important to measure this parameter. A method for the measurement of G in glass-resin fibres, the V-notched beam method (Iosipescu method) , was applied. The particular shape of the rectangular Iosipescu V- notched sample and the particular modality of force application produce pure shear stress for a reliable measurement of the G value and of the shear strength of the insulation. The effect of temperature on these mechanical properties was also investigated. Results show higher averag...

  15. Authenticity and TV Shows: A Multidimensional Analysis Perspective

    Al-Surmi, Mansoor

    2012-01-01

    Television shows, especially soap operas and sitcoms, are usually considered by English as a second language practitioners as a source of authentic spoken conversational materials presumably because they reflect the linguistic features of natural conversation. However, practitioners are faced with the dilemma of how to assess whether such…

  16. SSR fingerprinting of black raspberry cultivars shows discrepancies in identification

    Breeding progress in black raspberry (Rubus occidentalis L.) has been limited by a lack of genetic diversity in elite germplasm. Black raspberry cultivars are noted for showing very few differences, and seedlings for a lack of segregation for important traits. Genetic fingerprinting using microsatel...

  17. The role of prosody in a Czech talk-show

    Havlík, Martin

    Amsterdam : Benjamins, 2012 - (Lorda, C.; Zabalbeascoa, P.), s. 143-160 ISBN 978-90-272-1032-6. - (Dialogue Studies. 15) R&D Projects: GA AV ČR KJB900610701; GA ČR GA405/09/2028 Institutional research plan: CEZ:AV0Z90610518 Keywords : prosody * TV talk-show * conversation analysis Subject RIV: AI - Linguistics

  18. Mice lacking neuropeptide Y show increased sensitivity to cocaine

    Sørensen, Gunnar; Woldbye, David Paul Drucker

    2012-01-01

    There is increasing data implicating neuropeptide Y (NPY) in the neurobiology of addiction. This study explored the possible role of NPY in cocaine-induced behavior using NPY knockout mice. The transgenic mice showed a hypersensitive response to cocaine in three animal models of cocaine addiction...

  19. Going through the 33rd Tokyo Motor Show. Passenger cars and motorcycles show in the last 20th century; Dai 33 kai Tokyo Motor Show kenbunki. 20 seiki saigono joyosha nirinsha show ga miseta mono

    Mihori, N.

    2000-01-01

    This paper summarizes what has been seen and heard at the 33rd Motor Show held in the city of Chiba in October 1999. The Show has become a show dedicated to passenger cars and motorcycles. Exhibitors included six governments, one organization and 287 companies from 15 countries. Designs were better in European and American cars than in Japanese cars. Attitudes of tackling with direct gasoline injection systems were seen in the Japanese makers, as well as in European car makers who are indicated of the same movement. Further low fuel consumption is in progress by combining the direct gasoline injection with controls and power trains. Another one that has been highlighted was the bybrids. Development of high-performance batteries has also been advanced, where a conception was born that a car is an energy reservoir. Every maker has announced power units using fuel cells. These cars have undecided issues such as how to prepare hydrogen, making when a car runs on road unpredictable. Having announced many light-weight cars made of aluminum was another feature of this year's show. Exhibition was made on technologies to make small motorcycles less polluting and less fuel consuming. A small bike mounted with a home use gas bomb was a unique appearance. (NEDO)

  20. Drosophila americana Diapausing Females Show Features Typical of Young Flies.

    Reis, Micael; Valer, Felipe B; Vieira, Cristina P; Vieira, Jorge

    2015-01-01

    Diapause is a period of arrested development which is controlled physiologically, preprogrammed environmentally and characterized by metabolic depression that can occur during any stage of insect development. Nevertheless, in the genus Drosophila, diapause is almost always associated with the cessation of ovarian development and reproductive activity in adult females. In this work, we show that, in D. americana (a temperate species of the virilis group), diapause is a genetically determined delay in ovarian development that is triggered by temperature and/or photoperiod. Moreover, we show that in this species diapause incidence increases with latitude, ranging from 13% in the southernmost to 91% in the northernmost range of the distribution. When exposed to diapause inducing conditions, both diapausing and non-diapausing females show a 10% increase in lifespan, that is further increased by 18.6% in diapausing females, although senescence is far from being negligible.ActinD1 expression levels suggest that diapausing females are biologically much younger than their chronological age, and that the fly as a whole, rather than the ovarian developmental one, which is phenotypically more evident, is delayed by diapause. Therefore, diapause candidate genes that show expression levels that are compatible with flies younger than their chronological age may not necessarily play a role in reproductive diapause and in adaptation to seasonally varying environmental conditions [corrected]. PMID:26398836

  1. Relapsed neuroblastomas show frequent RAS-MAPK pathway mutations

    Eleveld, Thomas F.; Oldridge, Derek A.; Bernard, Virginie; Koster, Jan; Daage, Leo Colmet; Diskin, Sharon J.; Schild, Linda; Bentahar, Nadia Bessoltane; Bellini, Angela; Chicard, Mathieu; Lapouble, Eve; Combaret, Valérie; Legoix-Né, Patricia; Michon, Jean; Pugh, Trevor J.; Hart, Lori S.; Rader, JulieAnn; Attiyeh, Edward F.; Wei, Jun S.; Zhang, Shile; Naranjo, Arlene; Gastier-Foster, Julie M.; Hogarty, Michael D.; Asgharzadeh, Shahab; Smith, Malcolm A.; Guidry Auvil, Jaime M.; Watkins, Thomas B. K.; Zwijnenburg, Danny A.; Ebus, Marli E.; van Sluis, Peter; Hakkert, Anne; van Wezel, Esther; van der Schoot, C. Ellen; Westerhout, Ellen M.; Schulte, Johannes H.; Tytgat, Godelieve A.; Dolman, M. Emmy M.; Janoueix-Lerosey, Isabelle; Gerhard, Daniela S.; Caron, Huib N.; Delattre, Olivier; Khan, Javed; Versteeg, Rogier; Schleiermacher, Gudrun; Molenaar, Jan J.; Maris, John M.

    2016-01-01

    The majority of neuroblastoma patients have tumors that initially respond to chemotherapy, but a large proportion of patients will experience therapy-resistant relapses. The molecular basis of this aggressive phenotype is unknown. Whole genome sequencing of 23 paired diagnostic and relapsed neuroblastomas showed clonal evolution from the diagnostic tumor with a median of 29 somatic mutations unique to the relapse sample. Eighteen of the 23 relapse tumors (78%) showed mutations predicted to activate the RAS-MAPK signaling pathway. Seven events were detected only in the relapse tumor while the others showed clonal enrichment. In neuroblastoma cell lines we also detected a high frequency of activating mutations in the RAS-MAPK pathway (11/18, 61%) and these lesions predicted for sensitivity to MEK inhibition in vitro and in vivo. Our findings provide the rationale for genetic characterization of relapse neuroblastoma and show that RAS-MAPK pathway mutations may function as a biomarker for new therapeutic approaches to refractory disease. PMID:26121087

  2. Teaching Job Interviewing Skills with the Help of Television Shows

    Bloch, Janel

    2011-01-01

    Because of its potential for humor and drama, job interviewing is frequently portrayed on television. This article discusses how scenes from popular television series such as "Everybody Loves Raymond," "Friends," and "The Mary Tyler Moore Show" can be used to teach effective job interview skills in business communication courses. Television…

  3. An autopsied case of tuberculous meningitis showing interesting CT findings

    A 61-year-old female patient died of a neurological disorder of unknown origin one month after the first visit and was found to have had tuberculous meningitis at autopsy. CT revealed a low density area showing an enlargement of the cerebral ventricle but did not reveal contrast enhancement in the basal cistern peculiar to tuberculous meningitis. (Namekawa, K.)

  4. Autopsied case of tuberculous meningitis showing interesting CT findings

    Abiko, Takashi; Higuchi, Hiroshi; Imada, Ryuichi; Nagai, Kenichi (Iwate Prefectural Central Hospital (Japan))

    1983-11-01

    A 61-year-old female patient died of a neurological disorder of unknown origin one month after the first visit and was found to have had tuberculous meningitis at autopsy. CT revealed a low density area showing an enlargement of the cerebral ventricle but did not reveal contrast enhancement in the basal cistern peculiar to tuberculous meningitis.

  5. Data from the Television Game Show "Friend or Foe?"

    Kalist, David E.

    2004-01-01

    The data discussed in this paper are from the television game show "Friend or Foe", and can be used to examine whether age, gender, race, and the amount of prize money affect contestants' strategies. The data are suitable for a variety of statistical analyses, such as descriptive statistics, testing for differences in means or proportions, and

  6. Relapsed neuroblastomas show frequent RAS-MAPK pathway mutations.

    Eleveld, Thomas F; Oldridge, Derek A; Bernard, Virginie; Koster, Jan; Daage, Leo Colmet; Diskin, Sharon J; Schild, Linda; Bentahar, Nadia Bessoltane; Bellini, Angela; Chicard, Mathieu; Lapouble, Eve; Combaret, Valrie; Legoix-N, Patricia; Michon, Jean; Pugh, Trevor J; Hart, Lori S; Rader, JulieAnn; Attiyeh, Edward F; Wei, Jun S; Zhang, Shile; Naranjo, Arlene; Gastier-Foster, Julie M; Hogarty, Michael D; Asgharzadeh, Shahab; Smith, Malcolm A; Guidry Auvil, Jaime M; Watkins, Thomas B K; Zwijnenburg, Danny A; Ebus, Marli E; van Sluis, Peter; Hakkert, Anne; van Wezel, Esther; van der Schoot, C Ellen; Westerhout, Ellen M; Schulte, Johannes H; Tytgat, Godelieve A; Dolman, M Emmy M; Janoueix-Lerosey, Isabelle; Gerhard, Daniela S; Caron, Huib N; Delattre, Olivier; Khan, Javed; Versteeg, Rogier; Schleiermacher, Gudrun; Molenaar, Jan J; Maris, John M

    2015-08-01

    The majority of patients with neuroblastoma have tumors that initially respond to chemotherapy, but a large proportion will experience therapy-resistant relapses. The molecular basis of this aggressive phenotype is unknown. Whole-genome sequencing of 23 paired diagnostic and relapse neuroblastomas showed clonal evolution from the diagnostic tumor, with a median of 29 somatic mutations unique to the relapse sample. Eighteen of the 23 relapse tumors (78%) showed mutations predicted to activate the RAS-MAPK pathway. Seven of these events were detected only in the relapse tumor, whereas the others showed clonal enrichment. In neuroblastoma cell lines, we also detected a high frequency of activating mutations in the RAS-MAPK pathway (11/18; 61%), and these lesions predicted sensitivity to MEK inhibition in vitro and in vivo. Our findings provide a rationale for genetic characterization of relapse neuroblastomas and show that RAS-MAPK pathway mutations may function as a biomarker for new therapeutic approaches to refractory disease. PMID:26121087

  7. Recurrent and multiple bladder tumors show conserved expression profiles

    Urothelial carcinomas originate from the epithelial cells of the inner lining of the bladder and may appear as single or as multiple synchronous tumors. Patients with urothelial carcinomas frequently show recurrences after treatment making follow-up necessary. The leading hypothesis explaining the origin of meta- and synchronous tumors assumes a monoclonal origin. However, the genetic relationship among consecutive tumors has been shown to be complex in as much as the genetic evolution does not adhere to the chronological appearance of the metachronous tumors. Consequently, genetically less evolved tumors may appear chronologically later than genetically related but more evolved tumors. Forty-nine meta- or synchronous urothelial tumors from 22 patients were analyzed using expression profiling, conventional CGH, LOH, and mutation analyses. We show by CGH that partial chromosomal losses in the initial tumors may not be present in the recurring tumors, by LOH that different haplotypes may be lost and that detected regions of LOH may be smaller in recurring tumors, and that mutations present in the initial tumor may not be present in the recurring ones. In contrast we show that despite apparent genomic differences, the recurrent and multiple bladder tumors from the same patients display remarkably similar expression profiles. Our findings show that even though the vast majority of the analyzed meta- and synchronous tumors from the same patients are not likely to have originated directly from the preceding tumor they still show remarkably similar expressions profiles. The presented data suggests that an expression profile is established early in tumor development and that this profile is stable and maintained in recurring tumors

  8. Latest data shows long-term security of uranium supply

    Full text: According to Uranium 2009: Resources, Production and Demand just published by the OECD Nuclear En ergy Agency (NEA) and the International Atomic Energy Agency (IAEA), uranium resources, production and demand are all on the rise. Exploration efforts have increased recently in line with the expected expansion of nuclear energy in the coming years. Total identified resources have grown but so too have costs of production. Worldwide exploration and mine development expenditures have more than doubled since the publication of the previous edition, Uranium 2007: Resources, Production and Demand. These expenditures have increased despite declining uranium market prices since mid- 2007. The uranium resources presented in this edition, reflecting the situation as of 1 January 2009, show that total identified resources amounted to 6 306 300 tU, an increase of about 15% compared to 2007, including those reported in the high-cost category (< USD 260/kgU or < USD 100/lbU O), reintroduced for the first time since the 1980s. This high-cost 3 8 category was used in the 2009 edition in response to the generally increased market prices for uranium in recent years, despite the decline since mid-2007, expectations of increasing demand as new nuclear power plants are being planned and built, and increased mining costs. Although total identified resources have increased overall, there has been a significant reduction in lower-cost resources owing to increased mining costs. At 2008 rates of consumption, total identified resources are sufficient for over 100 years of supply. The recognition by an increasing number of governments that nuclear power can produce competitively priced, baseload electricity that is essentially free of greenhouse gas emissions, coupled with the role that nuclear can play in enhancing security of energy supply, increases the prospects for growth in nuclear generating capacity, although the magnitude of that growth remains to be determined. According to capacity projections developed in this edition, by the year 2035, world nuclear capacity is projected to grow to between 500 and 785 GWe net. Accordingly, world reactor- related uranium requirements are also projected to rise. As observed in the past, increased investment in exploration has resulted in important discoveries and the identification of new resources. It is foreseen that, if market conditions improve further, additional exploration will be stimulated leading to the identification of additional resources of economic interest. Even in the high-growth scenario to 2035, less than half of the identified resources described in this edition would be consumed. The challenge remains to develop mines in a timely and environmentally sustainable fashion as uranium demand increases. A strong market will be required for these resources to be developed within the time frame required to meet future uranium demand. In addition, current projections of uranium mine production capacities could satisfy projected high-case world uranium requirements until the late 2020s. However, given the challenges and length of time associated with increasing production at existing mines and opening new mines, it is unlikely that all production increases will proceed as planned. As a result, secondary sources of previously mined uranium will continue to be required, complemented to the extent possible by uranium savings achieved by specifying lower tails assays at enrichment facilities and technical developments in fuel cycle technology. While the status of supply and demand is considered from today's technologies perspective, it should be recognised that the deployment of advanced reactor and fuel cycle technologies can positively affect the long-term availability of uranium and could conceivably extend it to thousands of years. These are some of the findings from Uranium 2009: Resources, Production and Demand , a joint study by the OECD/NEA and the IAEA, carried out in co-operation with their member countries and states and commonly referred to as the ''Red Book''. This is the 23rd edition of this periodic assessment (currently every two years) which has been published since the mid-1960s. (IAEA)

  9. Milky Way Monster Stars in Cosmic Reality Show

    2003-01-01

    The longest X-ray look yet at the supermassive black hole at the Milky Way's center has given astronomers unprecedented access to its life and times. The new data from NASA's Chandra X-ray Observatory revealed that our galaxy's central black hole is a frequent bad actor, prone to numerous outbursts and occasional large explosions. The observations of the black hole, a.k.a. Sagittarius A* or Sgr A*, occurred over a two-week period for a total exposure time of 164 hours. During this time Sgr A* flared up in X-ray intensity half a dozen or more times. Astronomers also found evidence that suggests it had an even more boisterous past. These discoveries will help to unlock the secrets of how Sgr A* grows and how it interacts with its environment "We are getting a look at the everyday life of a supermassive black hole like never before," said Frederick K. Baganoff of the Massachusetts Institute of Technology in Cambridge, who presented these new results on behalf of an international team at a press conference today at the American Astronomical Society meeting in Seattle. "We see it flaring on an almost daily basis." Sagittarius A* More images of Sagittarius A* The cause of the flares is not understood, but the rapidity with which they rise and fall indicates that they are occurring near the event horizon, or point of no return, around the black hole. Even when it flares, the intensity of the X-ray emission from the vicinity of the black hole is relatively weak, which suggests that Sgr A*, weighing in at 3 million times the mass of the Sun, is a starved black hole. "Although it appears to snack often, this black hole is definitely on a severe diet," says Baganoff. "This could be because explosive events in the past blew away much of the gas from the neighborhood of the black hole." Indeed, evidence for such events - which astronomers are viewing 26,000 years later due to the time it takes light to travel to Earth from the center of the Galaxy - can be found in the image. A faint streak of X-rays about 1 light-year long has been discovered 1.5 light years from Sgr A*. The streak points at Sgr A*, suggesting that it may be a jet of particles expelled at nearly the speed of light from just outside the event horizon of the black hole. The intensity and size of this jet indicate that the flaring activity has been occurring for many years. Labeled image of Sagittarius A* Jet Labeled image of Sagittarius A* Jet On a much larger scale, huge lobes of 20-million-degree-Centigrade gas extending over dozens of light years on either side of the black hole have also been discovered. "These lobes show that enormous explosions have occurred several times over the last ten thousand years," said Mark Morris of UCLA, lead author of a second paper on Sgr A*, who also participated in the press conference. Sangwook Park, of Penn State University in University Park, and Michael Muno, of MIT, were lead authors of two other papers presented at the meeting. These papers focused on the extraordinarily rich region around the central black hole, where they detected more than 2,000 X-ray sources. Other members of the team include Mark Bautz and George Ricker of MIT, Niel Brandt, Patrick Broos, George Chartas, Eric Feigelson, Gordon Garmire, and Leisa Townsley of Penn State, Yoshitomo Maeda of the Institute of Space and Astronautical Science in Japan, and Christian Howard of UCLA. NASA's Marshall Space Flight Center in Huntsville, Ala., manages the Chandra program, and TRW, Inc., Redondo Beach, Calif., is the prime contractor for the spacecraft. The Smithsonian's Chandra X-ray Center controls science and flight operations from Cambridge, Mass., for the Office of Space Science at NASA Headquarters, Washington. Images and additional information about this result are available at: http://chandra.harvard.edu and http://chandra.nasa.gov

  10. CMA Member Survey: Network Management Systems Showing Little Improvement.

    Lusa, John M.

    1998-01-01

    Discusses results of a survey of 112 network and telecom managers--members of the Communications Managers Association (CMA)--to identify problems relating to the operation of large enterprise networks. Results are presented in a table under categories of: respondent profile; network management systems; carrier management; enterprise management;…

  11. New Inspiring Planetarium Show Introduces ALMA to the Public

    2009-03-01

    As part of a wide range of education and public outreach activities for the International Year of Astronomy 2009 (IYA2009), ESO, together with the Association of French Language Planetariums (APLF), has produced a 30-minute planetarium show, In Search of our Cosmic Origins. It is centred on the global ground-based astronomical Atacama Large Millimeter/submillimeter Array (ALMA) project and represents a unique chance for planetariums to be associated with the IYA2009. ESO PR Photo 09a/09 Logo of the ALMA Planetarium Show ESO PR Photo 09b/09 Galileo's first observations with a telescope ESO PR Photo 09c/09 The ALMA Observatory ESO PR Photo 09d/09 The Milky Way band ESO PR Video 09a/09 Trailer in English ALMA is the leading telescope for observing the cool Universe -- the relic radiation of the Big Bang, and the molecular gas and dust that constitute the building blocks of stars, planetary systems, galaxies and life itself. It is currently being built in the extremely arid environment of the Chajnantor plateau, at 5000 metres altitude in the Chilean Andes, and will start scientific observations around 2011. ALMA, the largest current astronomical project, is a revolutionary telescope, comprising a state-of-the-art array of 66 giant 12-metre and 7-metre diameter antennas observing at millimetre and submillimetre wavelengths. In Search of our Cosmic Origins highlights the unprecedented window on the Universe that this facility will open for astronomers. "The show gives viewers a fascinating tour of the highest observatory on Earth, and takes them from there out into our Milky Way, and beyond," says Douglas Pierce-Price, the ALMA Public Information Officer at ESO. Edited by world fulldome experts Mirage3D, the emphasis of the new planetarium show is on the incomparable scientific adventure of the ALMA project. A young female astronomer guides the audience through a story that includes unique animations and footage, leading the viewer from the first observations by Galileo, 400 years ago, to the world of modern astronomy, moving from the visible wavelength domain to explore the millimetre-wave view of the Universe, and leaving light-polluted cities for unique settings in some of the highest and driest places on Earth. "The fascinating topic, the breathtaking ESO astronomical images, the amazing 3D computer animations, and the very clever use of the music, all make this a really inspiring show," says Agnès Acker, President of the APLF. In search of our Cosmic Origins is available in three different formats: fulldome video, classical with video windows, and classical with slides. Fulldome video shows immerse the audience in a true 360-degree projected computer-generated virtual environment. The ALMA planetarium show is currently available in French and English. Several other language versions are in preparation: German, Italian, Spanish and Chilean Spanish, while further languages are planned: Danish, Dutch, Greek, Japanese, Portuguese and Brazilian Portuguese. The show will be available to all planetariums worldwide for a small fee, depending on the type and the size of the planetarium, to cover basic costs. The media are invited to attend, and see firsthand, the official screening during the European Film Festival, between 24 and 26 April 2009 in Espinho, Portugal. For media accreditation, please go to http://iff.multimeios.pt/index.php?option=com_wrapper&Itemid=45 A set of educational materials is also being prepared and will be finished in late April. To learn more about the show, please go to www.cosmicorigins.org

  12. El reality show a la hora de la merienda

    Lic. Rosa María Ganga Ganga

    2000-01-01

    Full Text Available Los programas de testimonio, inscritos dentro del género televisivo del Reality Show, son una variante del más amplio subgénero del Talk Show y tienen ya una cierta tradición en nuestro país. El presente trabajo se centrará en este tipo de programas de testimonio que basan su estrategia discursiva en la presentación y representación del relato autobiográfico del hombre o la mujer anónimos, integrándose de esta forma en las corrientes más recientes de la sociología y la historiografía, y persigue esclarecer algunas de sus características y funciones, especialmente su función socializadora, a través del mecanismo biográfico y del concepto de habitus tomado de Pierre Bourdieu.

  13. Preschoolers show less trust in physically disabled or obese informants.

    Jaffer, Sara; Ma, Lili

    2014-01-01

    This research examined whether preschool-aged children show less trust in physically disabled or obese informants. In Study 1, when learning about novel physical activities and facts, 4- and 5-year-olds preferred to endorse the testimony of a physically abled, non-obese informant rather than a physically disabled or obese one. In Study 2, after seeing that the physically disabled or obese informant was previously reliable whereas the physically abled, non-obese one was unreliable, 4- and 5-year-olds did not show a significant preference for either informant. We conclude that in line with the literature on children's negative stereotypes of physically disabled or obese others, preschoolers are biased against these individuals as potential sources of new knowledge. This bias is robust in that past reliability might undermine its effect on children, but cannot reverse it. PMID:25610413

  14. Revisiting Dystopia: the Reality Show Biopolitics of "The Hunger Games"

    Fani Cettl

    2015-10-01

    Full Text Available This paper explores the dystopian imaginaries of the recent popular novel trilogy The Hunger Games by Suzanne Collins and its film adaptations. Having put the narrative into a genealogy of dystopian fiction concerned with the historical nation-state totalitarianisms, I ask what is specifically contemporary about The Hunger Games. I explore this by focusing on the functioning of the reality show format in the narrative, which I link to G. Agambens understanding of the spectacle, as part of his wider biopolitical theories. I apply an Agambenian biopolitical reading to the narrative, seeing it as a production of bare life through the camp of the reality show arena. I suggest that The Hunger Games offer a critique of contemporary liberal democracies by calling attention to their production of underclassed and expendable life, which is imagined as an eruption of the nation-state right to kill, similarly as in Agambens theories.

  15. Cerebral infarction showed hyperperfusion pattern on radionuclide cerebral angiography

    Four patients of middle cerebral infarctin showed hyperperfusion on radionuclide cerebral angiography and fan-shape accumulation at the area of middle cerebral artery on early and delayed brain scan. In these patients, bone scanning agents such as sup(99m)Tc-EHDP or sup(99m)Tc-MDP also prominently accumulated at the area of infarction. These findings were observed on the study when it was performed within seventeen days after attack, but reexamination tended to show normal or decreased perfusion on radionuclide cerebral angiography and improve abnormal accumulation on brain scans. The clinical diagnosis of these three patients were cerebral embolism with heart disease, but one patient was internal carotid artery occlusion. The prognosis of all patients were very good. The hyperperfusion on radionuclide cerebral angiography of these patients represents the luxury perfusion in the lesion and these infarction has been called hot stroke by Yarnell et al. (author)

  16. [A system for capturing and showing micrographs of genetics experiments].

    Li, Jian; Pan, Shen-Yuan; Zhu, Ming-Li; Gao, Tian-Hui; Liang, Qing-Shan; Liu, Hong-Xia

    2004-07-01

    A system for capturing and showing micrographs of genetics was designed with Microsoft Visual Basic 6.0. The system includes many functions such as capturing and editing images, typing and editing text, teaching experiments, showing images, image retrieval, database management, system maintenance and help, all of them were developed with the form of Windows. The system could collect images not only from image-grabber card in real-time but also from scanner, digital camera, clipboard and files. After utilizing the image compression technology, the images will be saved in database along with experiment instruction. With all the features referred above, the system can be used as a wonderful assistant both for the teaching of genetics experiments and for the students' learning by themselves. PMID:15640051

  17. Carcinoma showing thymus-like differentiation (CASTLE) with neuroendocrine differentiation.

    Yamazaki, Manabu; Fujii, Satoshi; Daiko, Hiroyuki; Hayashi, Ryuichi; Ochiai, Atsushi

    2008-12-01

    Carcinoma showing thymus-like differentiation (CASTLE) is a rare malignant neoplasm that histologically resembles thymic carcinoma and arises in the thyroid gland or adjacent soft tissue of the neck. Herein is reported the case of a 62-year-old male patient with CASTLE exhibiting neuroendocrine differentiation, who was treated with total pharyngolaryngo-esophagectomy and total thyroidectomy. Gross examination of the surgical specimen showed a grayish-white, solid, lobulated tumor, mainly located between the trachea and esophagus, and involving the lower part of the left thyroid lobe. Histologically, the tumor consisted of epithelial cell nests separated by thick fibrous septa. The tumor cells were polygonal in shape, and contained pale cytoplasm and a vesicular nucleus with prominent nucleoli. There were few mitotic figures. Rosette-like arrangements that suggested neuroendocrine differentiation were observed in part of the tumor. The tumor cells were positive for CD5 and neuroendocrine markers including synaptophysin and chromogranin A. PMID:19067852

  18. Human primary motor cortex shows hemispheric specialization for speech.

    Terumitsu, Makoto; Fujii, Yukihiko; Suzuki, Kiyotaka; Kwee, Ingrid L; Nakada, Tsutomu

    2006-07-31

    Hemispheric specialization is a prominent characteristic of the human brain. Should the 'dominant' hemisphere possess differential neural organization for language production in the 'higher order' cortex, it would be rational to consider that the primary motor cortex may also show similar hemispheric specialization for speech production. In order to test this hypothesis, we investigated the spatial distribution of neural activities associated with phonation (M1p), silent tongue motion (M1t), and vocalization (M1v) within the primary motor cortex, utilizing independent component-cross correlation-sequential epoch analysis of high-field functional magnetic resonance imaging time series. While M1t showed no significant differences between the two hemispheres, M1p and M1v exhibited significant hemispheric differences. The study demonstrated direct evidence that human primary motor cortex possesses clear-cut hemispheric specialization similar to that observed for the higher order cortices. PMID:16837833

  19. Exhibitor satisfaction in business-to-business trade shows

    Michael Reinhold; Stephan Reinhold; Christian Schmitz

    2010-01-01

    Tradeshows are an essential instrument in the marketing of goods and services. Thus, the fair and tradeshow business has become a multi-billion dollar industry, in which trade fair organizers earn the biggest share of sales with exhibitors, paying fees for exhibition services. In order to increase service quality on trade shows, trade fair organizers strive for achieving a high level of exhibitor satisfaction. Despite its major importance for the fair and tradeshow industry, instruments to po...

  20. The AIDS prevention magic show: avoiding the tragic with magic.

    Lustig, S L

    1994-01-01

    Teenagers are a crucial target group for interventions concerning acquired immunodeficiency syndrome (AIDS) and human immunodeficiency virus (HIV). Experimenting with their burgeoning sexuality and increased ability to obtain drugs, they are prime candidates for AIDS prevention and education strategies. The intervention described in this paper is a 30-minute magic show, presented by Cyrus (or Iris) the Virus, a sinister but entertaining character portrayed by any health educator willing to sp...

  1. Experimental Lung Cancer Drug Shows Early Promise | Poster

    By Frank Blanchard, Staff Writer A first-of-its-kind drug is showing early promise in attacking certain lung cancers that are hard to treat because they build up resistance to conventional chemotherapy. The drug, CO-1686, performed well in a preclinical study involving xenograft and transgenic mice, as reported in the journal Cancer Discovery. It is now being evaluated for safety and efficacy in Phase I and II clinical trials.

  2. Show Business: Deixis in Fifth-Century Athenian Drama

    Jacobson, David Julius

    2011-01-01

    In my dissertation I examine the use of deixis in fifth-century Athenian drama to show how a playwright's lexical choices shape an audience's engagement with and investment in a dramatic work. The study combines modern performance theories concerning the relationship between actor and audience with a detailed examination of the demonstratives hode and houtos in a representative sample of tragedy (and satyr play) and in the full Aristophanic corpus, and reaches conclusions that aid and expand...

  3. Ultra short yeast tropomyosins show novel myosin regulation.

    Maytum, Robin; Hatch, Victoria; Konrad, Manfred; Lehman, William; Geeves, Michael A

    2008-01-25

    Tropomyosin (Tm) is an alpha-helical coiled-coil actin-binding protein present in all eukaryotes from yeast to man. Its functional role has been best described in muscle regulation; however its much wider role in cytoskeletal actin regulation is still to be clarified. Isoforms vary in size from 284 or 248 amino acids in vertebrates, to 199 and 161 amino acids in yeast, spanning from 7 to 4 actin binding sites respectively. In Saccharomyces cerevisiae, the larger yTm1 protein is produced by an internal 38-amino acid duplication, corresponding to a single actin-binding site. We have produced an ultra-short Tm with only 125 amino acids by removing both of the 38 amino acid repeats from yTm1, with the addition of an Ala-Ser extension used to mimic the essential N-terminal acetylation. This short Tm, and an M1T mutant of it, bind to actin with a similar affinity to most Tms previously studied (K(50%) approximately 0.5 microm). However, an equilibrium fluorescence binding assay shows a much greater inhibition of myosin binding to actin than any previously studied Tm. Actin cosedimentation assays show this is caused by direct competition for binding to actin. The M1T mutant shows a reduced inhibition, probably due to weaker end-to-end interactions making it easier for myosin to displace Tm. All previously characterized Tms, although able to sterically block the myosin-binding site, are able to bind to actin along with myosin. By showing that Tm can compete directly with myosin for the same binding site these new Tms provide direct evidence for the steric blocking model. PMID:18006493

  4. About Goto's method showing surjectivity of word maps

    Elkasapy, Abdelrhman; Thom, Andreas

    2012-01-01

    Let F be the free group on two letters. For {\\omega} \\in F we study the associated word map {\\omega}: SU(n) \\times SU(n) \\rightarrow SU(n). Extending a method of Goto, we show that for {\\omega} not in the second derived subgroup F^(2) of F, there are infinitely many n \\in N such that the associated word map {\\omega} : SU(n) \\times SU(n) \\rightarrow SU(n) is surjective.

  5. FIVE KEPLER TARGET STARS THAT SHOW MULTIPLE TRANSITING EXOPLANET CANDIDATES

    We present and discuss five candidate exoplanetary systems identified with the Kepler spacecraft. These five systems show transits from multiple exoplanet candidates. Should these objects prove to be planetary in nature, then these five systems open new opportunities for the field of exoplanets and provide new insights into the formation and dynamical evolution of planetary systems. We discuss the methods used to identify multiple transiting objects from the Kepler photometry as well as the false-positive rejection methods that have been applied to these data. One system shows transits from three distinct objects while the remaining four systems show transits from two objects. Three systems have planet candidates that are near mean motion commensurabilities-two near 2:1 and one just outside 5:2. We discuss the implications that multi-transiting systems have on the distribution of orbital inclinations in planetary systems, and hence their dynamical histories, as well as their likely masses and chemical compositions. A Monte Carlo study indicates that, with additional data, most of these systems should exhibit detectable transit timing variations (TTVs) due to gravitational interactions, though none are apparent in these data. We also discuss new challenges that arise in TTV analyses due to the presence of more than two planets in a system.

  6. Five Kepler target stars that show multiple transiting exoplanet candidates

    Steffen, Jason H.; /Fermilab; Batalha, Natalie M.; /San Jose State U.; Borucki, William J.; /NASA, Ames; Buchhave, Lars A.; /Harvard-Smithsonian Ctr. Astrophys. /Bohr Inst.; Caldwell, Douglas A.; /NASA, Ames /SETI Inst., Mtn. View; Cochran, William D.; /Texas U.; Endl, Michael; /Texas U.; Fabrycky, Daniel C.; /Harvard-Smithsonian Ctr. Astrophys.; Fressin, Francois; /Harvard-Smithsonian Ctr. Astrophys.; Ford, Eric B.; /Florida U.; Fortney, Jonathan J.; /UC, Santa Cruz, Phys. Dept. /NASA, Ames

    2010-06-01

    We present and discuss five candidate exoplanetary systems identified with the Kepler spacecraft. These five systems show transits from multiple exoplanet candidates. Should these objects prove to be planetary in nature, then these five systems open new opportunities for the field of exoplanets and provide new insights into the formation and dynamical evolution of planetary systems. We discuss the methods used to identify multiple transiting objects from the Kepler photometry as well as the false-positive rejection methods that have been applied to these data. One system shows transits from three distinct objects while the remaining four systems show transits from two objects. Three systems have planet candidates that are near mean motion commensurabilities - two near 2:1 and one just outside 5:2. We discuss the implications that multitransiting systems have on the distribution of orbital inclinations in planetary systems, and hence their dynamical histories; as well as their likely masses and chemical compositions. A Monte Carlo study indicates that, with additional data, most of these systems should exhibit detectable transit timing variations (TTV) due to gravitational interactions - though none are apparent in these data. We also discuss new challenges that arise in TTV analyses due to the presence of more than two planets in a system.

  7. The Geology of Mars: What the New Global Map Shows

    Tanaka, K. L.; Dohm, J. M.; Fortezzo, C. M.; Irwin, R. P.; Kolb, E. J.; Skinner, J. A.; Hare, T. M.; Platz, T.; Michael, G.; Robbins, S.

    2012-03-01

    We describe how post-Viking data sets and our comprehensive, digital, team-based mapping approach have resulted in more robust unit identification, stratigraphic analysis, and understanding of geologic materials and features on Mars.

  8. Study shows ongoing benefits of cooling therapy for neonates.

    Holmström, Radhika

    2014-10-01

    OXYGEN DEPRIVATION at birth - perinatal asphyxia - is a well-known risk to children's health and development, resulting in permanent neurological damage that can include cerebral palsy and/or learning disability. PMID:25289614

  9. Hebbian plasticity combined with Homeostasis shows STDP-like behavior

    Christian Tetzlaff

    2010-09-01

    Full Text Available Functional properties of neural networks are dependent on the network connectivity. Connections between neurons are formed by synapses and are modified by different biological mechanisms. In this study, we considered the following three mechanisms: Hebbian, Homeostatic, and Spike-Timing-Dependent (STDP plasticity. In Hebbian plasticity (Dayan and Abbott, 2001 weight change depends on the activity rate of pre- and post-synaptic neuron and, thus, is a local learning rule, whereas in Homeostatic plasticity (Turrigiano and Nelson, 2004 weight change depends only on the rate of the post-synaptic neuron. This mechanism adjusts all synapses of the incoming inputs of the neuron and, therefore, is a global plasticity process. STDP, like Hebbian, is a local process, however, differently from Hebbian plasticity (which can only produce long-term potentiation; LTP it does not depend on the rates of pre- and post-synaptic neuron, but on the timing of the neuronal activity, and can either lead to LTP or LTD (long-term depression, Bi and Poo, 1998. However, STDP can be reformulated in a rate description (Izhikevich and Desai, 2003. In this study we are interested in the behavior of these three mechanisms with respect to the change of the dynamics when they interact with each other. To test this we analyzed single and two neuron systems analytically and numerically by looking at their fixed points in synapse development. We found out that these fixed points change their position and stability state (from stable to unstable or vice versa dependent on the plasticity parameters. We show that Hebbian together with Homeostatic plasticity shows qualitatively the same behavior as the rate description of STDP. This means that STDP, which has both LTP and LTD, can be a mixture of Hebbian and Homeostatic plasticity. In general, we show that dynamically different plasticity mechanisms change their behavior dramatically when they interact with each other.

  10. Prognosis of oocytes showing aggregation of smooth endoplasmic reticulum.

    Ebner, Thomas; Moser, Marianne; Shebl, Omar; Sommerguber, Michael; Tews, Gernot

    2008-01-01

    Few cytoplasmic dysmorphisms of oocytes have been reported to negatively influence the further fate of the ova. One such anomaly, namely the central aggregation of the smooth endoplasmic reticulum (SER), has recently been associated with suboptimal outcome in a limited number of patients. In order to increase prognostic value, it was decided to prospectively screen all intracytoplasmic sperm injection patients within 1 year for eggs showing aggregations of SER. In addition, all deliveries (obstetric and neonatal data) were analysed. Occurrence of SER cluster was related to duration (P oocytes without this anomaly involves a higher risk of detrimental outcome. PMID:18252056

  11. Preschoolers show less trust in physically disabled or obese informants

    Jaffer, Sara; Ma, Lili

    2015-01-01

    This research examined whether preschool-aged children show less trust in physically disabled or obese informants. In Study 1, when learning about novel physical activities and facts, 4- and 5-year-olds preferred to endorse the testimony of a physically abled, non-obese informant rather than a physically disabled or obese one. In Study 2, after seeing that the physically disabled or obese informant was previously reliable whereas the physically abled, non-obese one was unreliable, 4- and 5-ye...

  12. Dense mapping of IL18 shows no association in SLE

    Guerra, Sandra G.; David L. Morris; Gateva, Vesela; Robert R Graham; Vyse, Timothy J; Cunninghame Graham, Deborah S

    2010-01-01

    Systemic lupus erythematosus (SLE) is an autoimmune disease which behaves as a complex genetic trait. At least 20 SLE risk susceptibility loci have been mapped using both candidate gene and genome-wide association strategies. The gene encoding the pro-inflammatory cytokine, IL18, has been reported as a candidate gene showing an association with SLE. This pleiotropic cytokine is expressed in a range of immune cells and has been shown to induce interferon-γ and tumour necrosis factor-α. Serum i...

  13. DIY identity kit: the Great American Lesbian Art Show.

    Thompson, Margo Hobbs

    2010-01-01

    The Great American Lesbian Art Show, which opened at the Woman's Building in Los Angeles in May 1980, was conceived to increase visibility for lesbian artists, and to forge bonds among lesbians across the United States. It comprised a curated Invitational of ten artists and scores of regional GALAS events mounted simultaneously by women from Boston to Honolulu. The art on view, documented in a slide archive, staged a critique of contemporary gender norms. Participating artists represented lesbian identities that claimed universality while they reflected the artists' particularized experience of woman-identification and sexual desire. PMID:20408014

  14. Drilling and production - Economics show CO2 EOR potential

    Dubois, M.K.; Byrnes, A.P.

    2000-01-01

    CO2 EOR may be the key to recovering hundreds of millions of bbl of trapped oil from the mature fields in central Kansas. A simple model aided in assessing the economics of CO2 EOR for central Kansas and the Midcontinent. The model used CO2 Prophet, a DOE freeware reservoir numerical simulation program, to determine reservoir performance, including injected and produced fluid rates, and CO2 utilization. Economic parameters, e.g., oil price, CO2 costs, capital costs, net revenue interest, production taxes, and lease operating expenses, are typical for anticipated conditions in the region and present price climate. Preliminary economic analysis shows that CO2 EOR should give an internal rate of return (IRR) > 20%, before income tax, assuming oil sells for $20/bbl, CO2 costs $1/million cu ft, and gross utilization is 10 million cu ft of CO2/bbl of oil recovered. If the CO2 is reduced to $0.75/million cu ft, an oil price of $17/bbl yields an IRR of 20%. Reservoir and economic modeling shows that IRR is most sensitive to oil price and CO2 cost.

  15. Bilinguals Show Weaker Lexical Access During Spoken Sentence Comprehension.

    Shook, Anthony; Goldrick, Matthew; Engstler, Caroline; Marian, Viorica

    2015-12-01

    When bilinguals process written language, they show delays in accessing lexical items relative to monolinguals. The present study investigated whether this effect extended to spoken language comprehension, examining the processing of sentences with either low or high semantic constraint in both first and second languages. English-German bilinguals, German-English bilinguals and English monolinguals listened for target words in spoken English sentences while their eye-movements were recorded. Bilinguals' eye-movements reflected weaker lexical access relative to monolinguals; furthermore, the effect of semantic constraint differed across first versus second language processing. Specifically, English-native bilinguals showed fewer overall looks to target items, regardless of sentence constraint; German-native bilinguals activated target items more slowly and maintained target activation over a longer period of time in the low-constraint condition compared with monolinguals. No eye movements to cross-linguistic competitors were observed, suggesting that these lexical access disadvantages were present during bilingual spoken sentence comprehension even in the absence of overt interlingual competition. PMID:25266052

  16. Mice Lacking Endoglin in Macrophages Show an Impaired Immune Response

    Ojeda-Fernández, Luisa; Recio-Poveda, Lucía; Aristorena, Mikel; Lastres, Pedro; Blanco, Francisco J.; Sanz-Rodríguez, Francisco; Gallardo-Vara, Eunate; de las Casas-Engel, Mateo; Corbí, Ángel; Arthur, Helen M.; Bernabeu, Carmelo; Botella, Luisa M.

    2016-01-01

    Endoglin is an auxiliary receptor for members of the TGF-β superfamily and plays an important role in the homeostasis of the vessel wall. Mutations in endoglin gene (ENG) or in the closely related TGF-β receptor type I ACVRL1/ALK1 are responsible for a rare dominant vascular dysplasia, the Hereditary Hemorrhagic Telangiectasia (HHT), or Rendu-Osler-Weber syndrome. Endoglin is also expressed in human macrophages, but its role in macrophage function remains unknown. In this work, we show that endoglin expression is triggered during the monocyte-macrophage differentiation process, both in vitro and during the in vivo differentiation of blood monocytes recruited to foci of inflammation in wild-type C57BL/6 mice. To analyze the role of endoglin in macrophages in vivo, an endoglin myeloid lineage specific knock-out mouse line (Engfl/flLysMCre) was generated. These mice show a predisposition to develop spontaneous infections by opportunistic bacteria. Engfl/flLysMCre mice also display increased survival following LPS-induced peritonitis, suggesting a delayed immune response. Phagocytic activity is impaired in peritoneal macrophages, altering one of the main functions of macrophages which contributes to the initiation of the immune response. We also observed altered expression of TGF-β1 target genes in endoglin deficient peritoneal macrophages. Overall, the altered immune activity of endoglin deficient macrophages could help to explain the higher rate of infectious diseases seen in HHT1 patients. PMID:27010826

  17. Inconsistent handers show higher psychopathy than consistent handers.

    Shobe, Elizabeth; Desimone, Kailey

    2016-01-01

    Three hundred and forty-two university students completed the Short Dark Triad (SD3) and the Edinburgh Handedness Inventory (EHI). Inconsistent handers showed higher psychopathy scores than consistent handers, and no handedness differences were observed for narcissism or Machiavellianism. Participants were further subdivided by quartile into low, moderately low, moderately high, and high psychopathy groups (non-clinical). Absolute EHI scores were equally distributed among low and moderate groups, but were significantly lower for the high psychopathy group. These findings suggest that inconsistent handedness is only associated with the upper quartile of psychopathy scores. Also, males showed significantly higher psychopathy scores than females, and the ratio of male to female inconsistent handers decreased as psychopathy score increased. No gender × handedness interaction indicated that both female and male inconsistent handers have higher psychopathy scores than consistent handers. Although significant, the effects were small and 99.6% of participants were not in the range of a potential clinical diagnosis. The reader, therefore, is strongly cautioned against equating inconsistent handedness with psychopathy. PMID:26430938

  18. What does the Matlab fertility experience really show?

    Caldwell, J C; Caldwell, P

    1992-01-01

    The family planning program in the Matlab District of Bangladesh has been described in unique detail for more than 25 years and is regarded as a model for equally poor parts of the world. Its experience has been reported as showing the ineffectiveness of contraceptive saturation approaches and the prime importance of program management and especially of the selection of a special type of family planning household visitor, criteria that render family planning programs relatively expensive. This reanalysis of the Matlab experience suggests that there is inadequate evidence from which to judge the record of the saturation experiment and of family planning workers from less highly selected backgrounds. It is also argued here that the role of contraceptive choice and of access to different types of contraceptives, especially injectables, delivered to the door in this society of secluded women has been underestimated, and that too little importance has been attributed to demand in contrast to supply. While it is agreed that the Matlab demonstration has been of central importance in showing that fertility can be reduced in Bangladesh, it is argued that many developing countries can draw on this experience to provide less costly family planning programs with less emphasis on the managerial, top-down approach. PMID:1475797

  19. CERN's gamble shows perils, rewards of playing the odds

    Seife, C

    2000-01-01

    Data from LEP has a three to four sigma certainty that the Higgs Boson has been seen. To declare a discovery though, normally five sigma is required. This article examines other occasions where even with this degree of certainty, the results finally turned out to be spurious (3 pages).

  20. Protein Replacement Therapy Shows Promise in Treating Rare Skin Disorder

    ... Molecular Therapy and the Journal of Investigative Dermatology. Epidermolysis bullosa (EB) is a family of disorders caused by ... human recombinant C7 (rC7) in mouse RDEB models. Epidermolysis bullosa occurs when genetic defects result in the skin’s ...

  1. Counselor Educator, Don't Tell Us, Show Us

    Becvar, Raphael J.; Dustin, Richard

    1974-01-01

    In today's social systems, the current model of proactive counseling seems more functional than does waiting for clients. However, those counselor educators who train for proactive counselor roles must assume responsibility for assisting the implementation of the resulting role change. (Author)

  2. Satellite signal shows storage-unloading subsidence in North China

    J. P. Moiwo

    2015-06-01

    Full Text Available Worsening water storage depletion (WSD contributes to environmental degradation, land subsidence and earthquake and could disrupt food production/security and social stability. There is need for efficient water use strategies in North China, a pivotal agrarian, industrial and political base in China with a widespread WSD. This study integrates satellite, model and field data products to investigate WSD and land subsidence in North China. In the first step, GRACE (Gravity Recovery and Climate Experiment mass rates are used to show WSD in the region. Next, GRACE total water storage (TWS is corrected for soil water storage (SWS to derive groundwater storage (GWS using GLDAS (Global Land Data Assimilation System data products. The derived GWS is compared with GWS obtained from field-measured groundwater level to show land subsidence in the study area. Then GPS (Global Positioning System data of relative land surface change (LSC are used to confirm the subsidence due to WSD. A total of ~ 96 near-consecutive months (January 2002 through December 2009 of datasets are used in the study. Based on GRACE mass rates, TWS depletion is 23.76 ± 1.74 mm yr−1 or 13.73 ± 1.01 km3 yr−1 in the 578 000 km2 study area. This is ~ 31 % of the slated 45 km3 yr−1 water delivery in 2050 via the South–North Water Diversion Project. Analysis of relative LSC shows subsidence of 7.29 ± 0.35 mm yr−1 in Beijing and 2.74 ± 0.16 mm yr−1 in North China. About 11.53 % (2.74 ± 0.18 mm or 1.58 ± 0.12 km3 of the TWS and 8.37 % (1.52 ± 0.70 mm or 0.88 ± 0.03 km3 of the GWS are attributed to storage reductions accompanying subsidence in the region. Although interpretations of the findings require caution due to the short temporal and large spatial coverage, the concurrence of WSD and land subsidence could have adverse implications for the study area. It is critical that the relevant stakeholders embark on resource-efficient measures to ensure water availability, food security, ecological sustainability and social stability in this pivotal region.

  3. Satellite signal shows storage-unloading subsidence in North China

    Moiwo, J. P.; Tao, F.

    2015-06-01

    Worsening water storage depletion (WSD) contributes to environmental degradation, land subsidence and earthquake and could disrupt food production/security and social stability. There is need for efficient water use strategies in North China, a pivotal agrarian, industrial and political base in China with a widespread WSD. This study integrates satellite, model and field data products to investigate WSD and land subsidence in North China. In the first step, GRACE (Gravity Recovery and Climate Experiment) mass rates are used to show WSD in the region. Next, GRACE total water storage (TWS) is corrected for soil water storage (SWS) to derive groundwater storage (GWS) using GLDAS (Global Land Data Assimilation System) data products. The derived GWS is compared with GWS obtained from field-measured groundwater level to show land subsidence in the study area. Then GPS (Global Positioning System) data of relative land surface change (LSC) are used to confirm the subsidence due to WSD. A total of ~ 96 near-consecutive months (January 2002 through December 2009) of datasets are used in the study. Based on GRACE mass rates, TWS depletion is 23.76 ± 1.74 mm yr-1 or 13.73 ± 1.01 km3 yr-1 in the 578 000 km2 study area. This is ~ 31 % of the slated 45 km3 yr-1 water delivery in 2050 via the South-North Water Diversion Project. Analysis of relative LSC shows subsidence of 7.29 ± 0.35 mm yr-1 in Beijing and 2.74 ± 0.16 mm yr-1 in North China. About 11.53 % (2.74 ± 0.18 mm or 1.58 ± 0.12 km3) of the TWS and 8.37 % (1.52 ± 0.70 mm or 0.88 ± 0.03 km3) of the GWS are attributed to storage reductions accompanying subsidence in the region. Although interpretations of the findings require caution due to the short temporal and large spatial coverage, the concurrence of WSD and land subsidence could have adverse implications for the study area. It is critical that the relevant stakeholders embark on resource-efficient measures to ensure water availability, food security, ecological sustainability and social stability in this pivotal region.

  4. THE HEROIC CULT IN RADIO SHOWS IN ROMANIA

    Florica IUHAȘ

    2015-12-01

    Full Text Available A people’s cultural and historical past, represented as community’s destiny, is memorized and sent down, from one generation to the next, through the many channels of popular orality: legends, ballads, popular poetry and also through those chanels more specific to modern times, such as patriotic songs, cultivated poetry, fiction (especially historical novels, history, histories, films, etc. Through their educational purpose, but also through their emotional/affective packaging, all these do manage the collective past and determine the manner in which the historical time is perceived in a patromonial and affective fashion, as national past. The present study wishes to analyze the manner in which Romanian radio stations covered the events organized on the Heroes’ Day in 2014, to identify the themes of the radio coverage and to assess whether the current radio shows are able to ensure a memory link or connection between generations.

  5. Dense mapping of IL18 shows no association in SLE

    Guerra, Sandra G.; Morris, David L.; Gateva, Vesela; Graham, Robert R.; Vyse, Timothy J.; Cunninghame Graham, Deborah S.

    2011-01-01

    Systemic lupus erythematosus (SLE) is an autoimmune disease which behaves as a complex genetic trait. At least 20 SLE risk susceptibility loci have been mapped using both candidate gene and genome-wide association strategies. The gene encoding the pro-inflammatory cytokine, IL18, has been reported as a candidate gene showing an association with SLE. This pleiotropic cytokine is expressed in a range of immune cells and has been shown to induce interferon-γ and tumour necrosis factor-α. Serum interleukin-18 has been reported to be elevated in patients with SLE. Here we aimed to densely map single nucleotide polymorphisms (SNPs) across IL18 to investigate the association across this locus. We genotyped 36 across IL18 by Illumina bead express in 372 UK SLE trios. We also genotyped these SNPs in a further 508 non-trio UK cases and were able to accurately impute a dense marker set across IL18 in WTCCC2 controls with a total of 258 SNPs. To improve the study's power, we also imputed a total of 158 SNPs across the IL18 locus using data from an SLE genome-wide association study and performed association testing. In total, we analysed 1818 cases and 10 770 controls in this study. Our large well-powered study (98% to detect odds ratio = 1.5, with respect to rs360719) showed that no individual SNP or haplotype was associated with SLE in any of the cohorts studied. We conclude that we were unable to replicate the SLE association with rs360719 located upstream of IL18. No evidence for association with any other common variant at IL18 with SLE was found. PMID:21149337

  6. Low LET protons focused to submicrometer shows enhanced radiobiological effectiveness

    Schmid, T. E.; Greubel, C.; Hable, V.; Zlobinskaya, O.; Michalski, D.; Girst, S.; Siebenwirth, C.; Schmid, E.; Molls, M.; Multhoff, G.; Dollinger, G.

    2012-10-01

    This study shows that enhanced radiobiological effectiveness (RBE) values can be generated focusing low linear energy transfer (LET) radiation and thus changing the microdose distribution. 20 MeV protons (LET = 2.65 keV µm-1) are focused to submicrometer diameter at the ion microprobe superconducting nanoprobe for applied nuclear (Kern) physics experiments of the Munich tandem accelerator. The RBE values, as determined by measuring micronuclei (RBEMN = 1.48 ± 0.07) and dicentrics (RBED = 1.92 ± 0.15), in human-hamster hybrid (AL) cells are significantly higher when 117 protons were focused to a submicrometer irradiation field within a 5.4 × 5.4 µm2 matrix compared to quasi homogeneous in a 1 × 1 µm2 matrix applied protons (RBEMN = 1.28 ± 0.07; RBED = 1.41 ± 0.14) at the same average dose of 1.7 Gy. The RBE values are normalized to standard 70 kV (dicentrics) or 200 kV (micronuclei) x-ray irradiation. The 117 protons applied per point deposit the same amount of energy like a 12C ion with 55 MeV total energy (4.48 MeV u-1). The enhancements are about half of that obtained for 12C ions (RBEMN = 2.20 ± 0.06 and RBED = 3.21 ± 0.10) and they are attributed to intertrack interactions of the induced damages. The measured RBE values show differences from predictions of the local effect model (LEM III) that is used to calculate RBE values for irradiation plans to treat tumors with high LET particles.

  7. Low LET protons focused to submicrometer shows enhanced radiobiological effectiveness

    This study shows that enhanced radiobiological effectiveness (RBE) values can be generated focusing low linear energy transfer (LET) radiation and thus changing the microdose distribution. 20 MeV protons (LET = 2.65 keV µm−1) are focused to submicrometer diameter at the ion microprobe superconducting nanoprobe for applied nuclear (Kern) physics experiments of the Munich tandem accelerator. The RBE values, as determined by measuring micronuclei (RBEMN = 1.48 ± 0.07) and dicentrics (RBED = 1.92 ± 0.15), in human–hamster hybrid (AL) cells are significantly higher when 117 protons were focused to a submicrometer irradiation field within a 5.4 × 5.4 µm2 matrix compared to quasi homogeneous in a 1 × 1 µm2 matrix applied protons (RBEMN = 1.28 ± 0.07; RBED = 1.41 ± 0.14) at the same average dose of 1.7 Gy. The RBE values are normalized to standard 70 kV (dicentrics) or 200 kV (micronuclei) x-ray irradiation. The 117 protons applied per point deposit the same amount of energy like a 12C ion with 55 MeV total energy (4.48 MeV u−1). The enhancements are about half of that obtained for 12C ions (RBEMN = 2.20 ± 0.06 and RBED = 3.21 ± 0.10) and they are attributed to intertrack interactions of the induced damages. The measured RBE values show differences from predictions of the local effect model (LEM III) that is used to calculate RBE values for irradiation plans to treat tumors with high LET particles. (paper)

  8. Non-asthmatic patients show increased exhaled nitric oxide concentrations

    Beatriz M., Saraiva-Romanholo; Fabio S., Machado; Francine M., Almeida; Maria do Patrocnio T., Nunes; Milton A., Martins; Joaquim E., Vieira.

    2009-01-01

    Full Text Available OBJECTIVE: Evaluate whether exhaled nitric oxide may serve as a marker of intraoperative bronchospasm. INTRODUCTION: Intraoperative bronchospasm remains a challenging event during anesthesia. Previous studies in asthmatic patients suggest that exhaled nitric oxide may represent a noninvasive measure [...] of airway inflammation. METHODS: A total of 146,358 anesthesia information forms, which were received during the period from 1999 to 2004, were reviewed. Bronchospasm was registered on 863 forms. From those, three groups were identified: 9 non-asthmatic patients (Bronchospasm group), 12 asthmatics (Asthma group) and 10 subjects with no previous airway disease or symptoms (Control group). All subjects were submitted to exhaled nitric oxide measurements (parts/billion), spirometry and the induced sputum test. The data was compared by ANOVA followed by the Tukey test and Kruskal-Wallis followed by Dunn's test. RESULTS: The normal lung function test results for the Bronchospasm group were different from those of the asthma group (p

  9. Distinct iPS Cells Show Different Cardiac Differentiation Efficiency

    Yohei Ohno; Shinsuke Yuasa; Toru Egashira; Tomohisa Seki; Hisayuki Hashimoto; Shugo Tohyama; Yuki Saito; Akira Kunitomi; Kenichiro Shimoji; Takeshi Onizuka; Toshimi Kageyama; Kojiro Yae; Tomofumi Tanaka; Ruri Kaneda; Fumiyuki Hattori

    2013-01-01

    Patient-specific induced pluripotent stem (iPS) cells can be generated by introducing transcription factors that are highly expressed in embryonic stem (ES) cells into somatic cells. This opens up new possibilities for cell transplantation-based regenerative medicine by overcoming the ethical issues and immunological problems associated with ES cells. Despite the development of various methods for the generation of iPS cells that have resulted in increased efficiency, safety, and general vers...

  10. The staff show their profound attachment to SLS

    Association du personnel

    2007-01-01

    The results of the poll on the Saved Leave Scheme (SLS) have now been analyzed and are published in this edition and on our web site. You were 1194 to reply to the questionnaire (approximately 50% of all staff members). The distribution of the replies according to certain variables (sex, age, career path, etc.) in the sample corresponds to the one observed for the overall staff population. This indicates that the sample is representative.

  11. Natural Product Shows Effectiveness in Combating Colorectal Cancer | Poster

    An herbal extract used for centuries to prevent heart disease has now been shown to be effective against colorectal cancer when tested in laboratory cell cultures. Scientists from NCI at Frederick found that the natural extract cryptotanshinone (CPT) stops the uncontrolled cell growth characteristic of cancer by interfering with a protein that has been implicated in several cancers, including those of the colon and rectum. The results appear in the journal Molecular and Cellular Biochemistry.

  12. Measuring Political Polarization: Twitter shows the two sides of Venezuela

    Morales, A. J.; Borondo, J.; Losada, J. C.; Benito, R. M.

    2015-01-01

    We say that a population is perfectly polarized when divided in two groups of the same size and opposite opinions. In this paper, we propose a methodology to study and measure the emergence of polarization from social interactions. We begin by proposing a model to estimate opinions in which a minority of influential individuals propagate their opinions through a social network. The result of the model is an opinion probability density function. Next, we propose an index to quantify the extent...

  13. Krukenberg tumor. Report of a case showing a pathological correlation

    Krukenberg tumor is a broad term that encompasses all the metastatic ovarian lesions but, in the strictest sense, it includes only those secondary tumors containing mucin-secreting signet ring cells. We present a case of Krukenberg tumor involving a mucinous gastric adenocarcinoma with signet ring cells, correlating the ultrasound and computed tomography findings with the results of the necropsy study and reviewing the description in the literature. (Author) 15 refs

  14. Does ELF chorus show evidence of power line stimulation

    It has previously been reported that electromagnetic chorus exhibits a longitudinal dependence, with enhanced occurrence over population centers (Alaska-New Zealand, Eastern U.S.-Canada, Western Europe and Western Siberia). This result has been cited as possible evidence of Power Line Harmonic Radiation (PLR) control of magnetospheric chorus. In this paper the authors report an analogous study using chorus data from OGO-5 to test this result. Chorus is found to exhibit maxima over the Eastern USSR, Greenland and Central Siberia and minima over central and Eastern Canada, a distribution significantly different than the OGO-3 result. This gross discrepancy is explained as an effect of data oversampling (presistence) in the method of analysis used in the previous study. The OGO-5 data are reanalysed with the oversampling removed. It is found that none of the longitudinal maxima or minima are then statistically significant (<2sigma). Thus, they find no statistically significant correlation between longitude and chorus occurrence which implies that there is little or no evidence of PLR effects on chorus triggering. (Auth.)

  15. Comparison of transition temperature shifts from static and dynamic tests

    Paper summarizes results of surveillance specimens programmes of WWER-440/V-213C type reactors. Comparison of transition temperature shifts, induced by irradiation, and determined from impact Charpy V-notch toughness as well as from static fracture toughness tests on pre-cracked Charpy size specimens (COD) is given. Two methods have been used for determination of static fracture toughness shifts - standard COD type specimens from a standard surveillance programmes and reconstituted COD type specimens from broken halves of Charpy V-notch specimens. Results obtained are discussed from the point of view of irradiation conditions as well as of different type of testing. (author)

  16. Fatigue crack growth rate determination during pre-cracking of fracture toughness specimens

    Fatigue crack growth rates were measured during pre-cracking of standard (Compact Tension) and non-standard (Charpy V-notch and Three-Point-Bend) fracture toughness specimens of two ferritic steels. Crack growth rates from the specimens were then compared with the results obtained from Compact Tension specimens following the procedures of ASTM designated standard test method. The experimental results and their analysis suggested the possibility of generating respective material crack growth rate data as a bonus during fatigue precracking of fracture toughness specimens including Charpy V-notch and Three-Point-Bend specimens. (author)

  17. Nano-textured W shows improvement of thermionic emission properties

    Laser-assisted nano-texturing of W substrates cathodes via ablation in liquid environment is experimentally realized. Two laser sources are used, either a Ti:sapphire femtosecond laser or a Nd:YAG laser with pulse duration of 350 ps. Laser exposure of W results in the formation of hemi-spherical nanostructures situated on top of periodic ripples. Nano-textured thermionic W cathode demonstrates the decrease of the efficient work function by 0.3 eV compared to pristine surface. (orig.)

  18. Porcine small intestine submucosa does not show antimicrobial properties.

    Holtom, Paul D; Shinar, Zachary; Benna, Jennifer; Patzakis, Michael J

    2004-10-01

    The goal of this study is to examine whether porcine small intestine submucosa (SIS) exhibits antimicrobial properties in a standard in vitro system, without pretreatment with acetic acid or extraction of soluble proteins. Previous animal studies suggest that porcine SIS may have inherent antibiotic properties. Using the guidelines for disk diffusion susceptibility testing by Bauer, 17/64-inch diameter disks made of porcine small intestine submucosa and of gortex were compared with standard antibiotic-impregnated disks against six organisms. The zone of inhibition was measured after 24 hours and minimum bacterial concentrations were determined by serial dilutions of a solution in which porcine small intestine submucosa was allowed to elute for 24 hours. Neither porcine SIS or gortex discs caused inhibition of the growth of any organism. The porcine small intestine submucosa discs showed bacterial growth on top of the discs whereas the gortex did not. Neither the dilutional concentrations of the porcine small intestine submucosa eluent nor the gortex eluent inhibited the growth of any organism. These findings suggest that the porcine small intestine submucosa does not have intrinsic antimicrobial properties. The growth of bacteria on top of the porcine small intestine submucosa suggests that porcine small intestine submucosa itself may provide a favorable environment for the growth of bacteria. More research is necessary to decide what role porcine small intestine submucosa plays in the treatment of infected surgical sites. PMID:15552130

  19. Ethical Sustainability in Scene Design of Iranian Children TV Shows

    Bushra Abbasi

    2015-07-01

    Full Text Available As the most efficient cognition source of children, TV programs can play an important role in fostering the priorities of Ethical Sustainability. Lack of attention in the field of scene design is addressing the absence of ethical sustainability requirements in the scene design principles. But, do the scene design principles in Iran have shortcomings? The aim of this paper is to define these shortcomings on the basis of ethical sustainability and present recommendations which can be considered by Iranian scene designers. The adopted methodology of research is case study, answering the research questions via qualitative data collection and descriptive-analytical technique. To achieve the aim of the research, the importance of ethical sustainability in the scene design of children TV shows is highlighted and the effect of design principles established by Islamic Republic of Iran Broadcasting Organization are reviewed through relevant literature and reliable documents. Then, through a comparison between Sustainable Principles of Hannover and the mentioned Iranian design principles on the basis of sustainable relations, shortcomings of principles are discovered. In addition, the selected case study of the research is the scene of “Fitileh TV show” which was successfully designed in accordance to the mentioned Iranian design principles. The current practice of established design principles are examined through direct observation and visual evaluation and presented in a clear view. The effects of the shortcomings of the afore-mentioned design principles on the designed scene are evaluated afterwards and the recommendations are presented. 

  20. Maps Showing Seismic Landslide Hazards in Anchorage, Alaska

    Jibson, Randall W.; Michael, John A.

    2009-01-01

    The devastating landslides that accompanied the great 1964 Alaska earthquake showed that seismically triggered landslides are one of the greatest geologic hazards in Anchorage. Maps quantifying seismic landslide hazards are therefore important for planning, zoning, and emergency-response preparation. The accompanying maps portray seismic landslide hazards for the following conditions: (1) deep, translational landslides, which occur only during great subduction-zone earthquakes that have return periods of =~300-900 yr; (2) shallow landslides for a peak ground acceleration (PGA) of 0.69 g, which has a return period of 2,475 yr, or a 2 percent probability of exceedance in 50 yr; and (3) shallow landslides for a PGA of 0.43 g, which has a return period of 475 yr, or a 10 percent probability of exceedance in 50 yr. Deep, translational landslide hazard zones were delineated based on previous studies of such landslides, with some modifications based on field observations of locations of deep landslides. Shallow-landslide hazards were delineated using a Newmark-type displacement analysis for the two probabilistic ground motions modeled.

  1. Ultrasonic frogs show hyperacute phonotaxis to female courtship calls.

    Shen, Jun-Xian; Feng, Albert S; Xu, Zhi-Min; Yu, Zu-Lin; Arch, Victoria S; Yu, Xin-Jian; Narins, Peter M

    2008-06-12

    Sound communication plays a vital role in frog reproduction, in which vocal advertisement is generally the domain of males. Females are typically silent, but in a few anuran species they can produce a feeble reciprocal call or rapping sounds during courtship. Males of concave-eared torrent frogs (Odorrana tormota) have demonstrated ultrasonic communication capacity. Although females of O. tormota have an unusually well-developed vocal production system, it is unclear whether or not they produce calls or are only passive partners in a communication system dominated by males. Here we show that before ovulation, gravid females of O. tormota emit calls that are distinct from males' advertisement calls, having higher fundamental frequencies and harmonics and shorter call duration. In the field and in a quiet, darkened indoor arena, these female calls evoke vocalizations and extraordinarily precise positive phonotaxis (a localization error of dolphins, elephants and humans). The localization accuracy of O. tormota is remarkable in light of their small head size (interaural distance of <1 cm), and suggests an additional selective advantage of high-frequency hearing beyond the ability to avoid masking by low-frequency background noise. PMID:18469804

  2. Glioma-associated endothelial cells show evidence of replicative senescence

    The innately programmed process of replicative senescence has been studied extensively with respect to cancer, but primarily from the perspective of tumor cells overcoming this stringent innate barrier and acquiring the capacity for unlimited proliferation. In this study, we focus on the potential role of replicative senescence affecting the non-transformed endothelial cells of the blood vessels within the tumor microenvironment. Based on the well-documented aberrant structural and functional features of blood vessels within solid tumors, we hypothesized that tumor-derived factors may lead to premature replicative senescence in tumor-associated brain endothelial cells (TuBEC). We show here that glioma tissue, but not normal brain tissue, contains cells that express the signature of replicative senescence, senescence-associated β-galactosidase (SA-β-gal), on CD31-positive endothelial cells. Primary cultures of human TuBEC stain for SA-β-gal and exhibit characteristics of replicative senescence, including increased levels of the cell cycle inhibitors p21 and p27, increased resistance to cytotoxic drugs, increased growth factor production, and inability to proliferate. These data provide the first demonstration that tumor-derived brain endothelial cells may have reached an end-stage of differentiation known as replicative senescence and underscore the need for anti-angiogenic therapies to target this unique tumor-associated endothelial cell population

  3. Dictyostelium development shows a novel pattern of evolutionary conservation.

    Tian, Xiangjun; Strassmann, Joan E; Queller, David C

    2013-04-01

    von Baer's law states that early stages of animal development are the most conserved. More recent evidence supports a modified "hourglass" pattern in which an early but somewhat later stage is most conserved. Both patterns have been explained by the relative complexity of either temporal or spatial interactions; the greatest conservation and lowest evolvability occur at the time of the most complex interactions, because these cause larger effects that are harder for selection to alter. This general kind of explanation might apply universally across independent multicellular systems, as supported by the recent finding of the hourglass pattern in plants. We use RNA-seq expression data from the development of the slime mold Dictyostelium to demonstrate that it does not follow either of the two canonical patterns but instead tends to show the strongest conservation and weakest evolvability late in development. We propose that this is consistent with a version of the spatial constraints model, modified for organisms that never achieve a high degree of developmental modularity. PMID:23329689

  4. Show: Dr. H, the life and death of pancakes

    2012-01-01

    Dr. H, the life and death of pancakes, a comic theatrical creation, written and performed by Heiko Buchholz.   Monday 2 April 2012 in German Tuesday 3 April 2012 in English Wednesday 4 April 2012 in French 8:30 p.m. at the Globe of Science and Innovation. This production takes a comic look at scientific methods, as applied to a common object: the pancake. More specifically, Dr H. regales his audience with statistics, experiments and scientific data surrounding this egg-and-milk-based culinary delight. And although these zany sketches are nothing short of absurd, the audience is drawn in more often than you might expect… and taken on quite an unexpected journey into the behavioural disorders, personality quirks and psychoanalysis of the base pancake. This show playfully mocks scientific logic and discourse, forcing the audience to reflect on their gullibility in the face of science and its impenetrable jargon. It purports to be neither explanation nor illustration of scientific fact,...

  5. Sulfur dioxide: episodic injection shows evidence for active venus volcanism.

    Esposito, L W

    1984-03-01

    Pioneer Venus ultraviolet spectra from the first 5 years of operation show a decline (by more than a factor of 10) in sulfur dioxide abundance at the cloud tops and in the amount of submicron haze above the clouds. At the time of the Pioneer Venus encounter, the values for both parameters greatly exceeded earlier upper limits. However, Venus had a similar appearance in the late 1950's, implying the episodic injection of sulfur dioxide possibly caused by episodic volcanism. The amount of haze in the Venus middle atmosphere is about ten times that found in Earth's stratosphere after the most recent major volcanic eruptions, and the thermal energy required for this injection on Venus is greater by about an order of magnitude than the largest of these recent Earth eruptions and about as large as the Krakatoa eruption of 1883. The episodic behavior of sulfur dioxide implies that steady-state models of the chemistry and dynamics of cloud-top regions may be of limited use. PMID:17830154

  6. Sulfur dioxide - Episodic injection shows evidence for active Venus volcanism

    Esposito, L. W.

    1984-01-01

    Pioneer Venus ultraviolet spectra from the first 5 years of operation show a decline (by more than a factor of 10) in sulfur dioxide abundance at the cloud tops and in the amount of submicron haze above the clouds. At the time of the Pioneer Venus encounter, the values for both parameters greatly exceeded earlier upper limits. However, Venus had a similar appearance in the late 1950's, implying the episodic injection of sulfur dioxide possibly caused by episodic volcanism. The amount of haze in the Venus middle atmosphere is about ten times that found in earth's stratosphere after the most recent major volcanic eruptions, and the thermal energy required for this injection on Venus is greater by about an order of magnitude than the largest of these recent earth eruptions and about as large as the Krakatoa eruption of 1883. The episodic behavior of sulfur dioxide implies that steady-state models of the chemistry and dynamics of cloud-top regions may be of limited use.

  7. Film showing - Higgs: into the heart of imagination

    CERN Bulletin

    2010-01-01

    On 29 April at 7pm Dutch filmmakers, Hannie van den Bergh and Jan van den Berg, will introduce their directorial debut, Higgs: into the heart of imagination in CERN’s Main Auditorium.   This documentary is about the curiousity, passion and imaginative powers of science. Featuring physicists working at CERN, in particular in ATLAS, and filmed over four years, the film-makers have created a cinematic journey into the heart of imagination. They follow Stan Bentvelsen, head of the Dutch research group at CERN, and watch as he prepares his team for the start of the LHC, as well as the scientific competition to find the elusive Higgs particle. The film also features Peter Higgs as he discusses his work from 1964. The directors have created theatre productions and other multimedia projects under the title The Imagination of Invisible Dimensions, which allow for adventurous dialogues between art and science. All are welcome to attend this showing and afterwards there will be a short question...

  8. Self-serving dishonest decisions can show facilitated cognitive dynamics.

    Tabatabaeian, Maryam; Dale, Rick; Duran, Nicholas D

    2015-08-01

    We use a novel task to test two competing hypotheses concerning the cognitive processes involved in dishonesty. Many existing accounts of deception imply that in order to act dishonestly one has to use cognitive control to overcome a bias toward the truth, which results in more time and effort. A recent hypothesis suggests that lying in order to serve self-interest may be a rapid, even automatic tendency taking less time than refraining from lying. In the current study, we track the action dynamics of potentially dishonest decisions to investigate the underlying cognitive processes. Participants are asked to privately predict the outcome of a virtual coin flip, report their accuracy and receive bonus credit for accurate predictions. The movements of the computer cursor toward the target answer are recorded and used to characterize the dynamics of decisions. Our results suggest that when a self-serving condition holds, decisions that have a high probability of being dishonest take less time and experience less hesitation. PMID:26082072

  9. Trajectory Hunting: Analysis of UARS Measurements showing Rapid Chlorine Activation

    Danilin, M.Y.; Santee, M. L.; Rodriquez, J. M.; Ko, M. K. W.; Mergenthaler, J. M.; Kumer, J. B.; Tabazadeh, A.

    1998-01-01

    Trajectory hunting (i.e., a technique to find air parcels sampled at least twice over the course of a few days) is applied to analyze Upper Atmosphere Research Satellite (UARS) measurements in conjunction with the AER photochemical box model. In this study, we investigate rapid chlorine activation in the Arctic lower stratosphere on 29 Dec 1992 associated with a polar stratospheric cloud (PSC) event. Six air parcels that have been sampled twice were followed along 5-day trajectories at the 465 K (approximately 46 mb) and 585 K (approximately 22 mb) levels. A detailed sensitivity study with the AER. photochemical box model along these trajectories leads to the following conclusions for the episode considered: (1) model results are in better agreement with UARS measurements at these levels if the UKMO temperature is decreased by at least 1-2 K; (2) the NAT (nitric acid trihydrate) PSC formation scheme produces results in better agreement with observations than the STS (supercooled ternary solution) scheme; (3) the model can explain the UARS measurements at 585 K, but under-estimates the ClO abundance at 465 K, suggesting some inconsistency between the UARS measurements at this level.

  10. Dust Storm Time Lapse Shows Opportunity's Skies Darken

    2007-01-01

    [figure removed for brevity, see original site] Dust Storm Time Lapse Shows Opportunity's Skies Darken NASA's Opportunity rover is literally seeing some of its darkest days. Both Mars Exploration Rovers have been riding out a regional dust storm for several weeks. Conditions became particularly dreary in the Meridiani Planum region where Opportunity sits, perched on the edge of 'Victoria Crater.' This image is a time-lapse composite where each horizon-survey image has been compressed horizontally (but not vertically) to emphasize the sky. The relative brightness and darkness of the sky from sol to sol (over a 30-sol period beginning June 14, 2007) is depicted accurately in these images, which view roughly the same part of the plains southwest of the rover. The images are approximately true color composites, generated from calibrated radiance data files using the panoramic camera's 601-nanometer, 535-nanometer and 482-nanometer filters. The rovers' atmospheric science team is concerned that smaller, regional dust storms could expand into a larger, globe-encircling storm. That could extend the time the sun stays obscured, challenging the capability of Opportunity's solar panels to produce enough electricity for the rover to function. Fortunately, as of July 19, 2007, the Opportunity site is clearing slightly. When the storm ends, atmospheric scientists hope to review data from the rovers that will help them determine what sort of dust was being lifted and distributed. The numbers across the top of the image report a measurement of atmospheric opacity, called by the Greek letter tau. The lower the number, the clearer the sky. Both Opportunity and Spirit have been recording higher tau measurements in July 2007 than they had seen any time previously in their three and a half years on Mars. The five sol numbers across the bottom correspond (left to right) to June 14, June 30, July 5, July 13 and July 15, 2007.

  11. A case of osseous scintigraphy showing focuses of multifocal tuberculosis

    Incidence of tuberculosis in developed countries presents in the last years a spectacular boost. However, the osteo-articular system is afflicted by tuberculosis only in a few percent of cases and the multifocal character represents less than 5% of osseous tuberculosis. It is presented here a case of multifocal osseous tuberculosis only to stress its rarity. A woman 28 years old from Djibouti presents since 8 months an asthenia and dorsal pains long thought as psychalgia. The examination has shown a major vertebral stiffness and limitation of right haunch. The radiographs showed a scoliosis centered on D8 with modifications. The biologic data are VS = 90, CRP = 124 and the hemogram is normal. The intradermal reaction (10 U of tuberculin) is phlyctenular. The TDM indicates lytic vertebral extension on D7 - D8, the osseous scintigraphy with MDP - 99 mTc indicates no anomaly in the vascular arrival time; a few minutes after injection: dorsal and upper and of right femur hyperactivity; 2 h after injection: hyper-fixation of D7 to D9 and of the upper end of right femur. The IRM indicates para-vertebral abscess of D7 to D9 with epidural abscess; abscess in the upper part of the loge of right adductors with osseous affliction of the femur's upper end; a bacillary infectious process was a priori evoked. The patient was then placed under quadruple antibiotic-therapy anti-tuberculous care. In case of anomalous multifocal osseous scintigraphy the tuberculous affliction is part of the differential diagnosis, particularly in the immigrant populations or in HIV+ persons

  12. Autistic Children Show More Efficient Parvocellular Visual Processing

    Alyse Brown

    2015-02-01

    Full Text Available As most studies of the cognitive neuroscience of autism employ high functioning individuals, there has been little attention paid to the relations between intelligence, perception and neurophysiological function. The efficiency of visual magnocellular and parvocellular processing using Wiener kernel analysis of the non-linear focal VEP was compared with psychophysical Global/Local Inspection Times (IT thresholds and related to nonverbal IQ in male Autistic (ASD and typically developing (TD control children (7-11 years. The non-linear VEP analysis showed that the ASD group produced smaller parvocellularly generated nonlinearities compared with the TD group. Strong relations between Global IT, non-verbal IQ and VEP Parvocellular efficiency were found in the ASD but not TD group, with no significant correlations found between local IT and non-verbal IQ for either group. This is the first direct physiological evidence of higher levels of parvocellular efficiency associated with global/local perceptual outcomes in autism. The observation of a relation in children with ASD, but not TDs, between global perception, non-verbal IQ and parvocellular neural recovery, suggests that in ASD fewer routes for information processing are being accessed in making cognitive/perceptual decisions. Ie, in order to demonstrate high non-verbal intelligence the probability is that the ASD child has simultaneously to demonstrate good global perceptual ability and to have a parvocellular visual system with excellent recovery after stimulation. In the TD population, there must exist alternate compensatory that allow for high nonverbal intelligence without constraint on global perception and neural function.

  13. Advertising Discourse Analysis of FES stores: Killing Love, Cowards Show

    Cristian Venegas Ahumada

    2013-08-01

    Full Text Available The objective is to analyze the structural and photographic discourse of the Autumn-Winter campaign 2008 of FES stores for young people. This was done by a semiotic theory and a critical-structural methodology of discourse. An analysis of 4 advertising photographs was done, and at once an analysis of the discourse “FES says no to violence against Women”, which explains the campaign’s target. The result is: The discourse was subjected to production condition (society of control and makes advertising a way to homogenize subjectivity of masses to consume. Recognition conditions demonstrate that this advertising discourse of symbolic violence means a type of violation of Men and Women Rights. An action like this requires commitment of Psychology in order to promote the social humanizing change, by means of university teaching and professional tasks.

  14. Phenolic compounds from leaves of Casimiroa edulis showed adipogenesis activity.

    Nagai, Hiroyuki; Tanaka, Toshiyuki; Goto, Tsuyoshi; Kusudo, Tatsuya; Takahashi, Nobuyuki; Kawada, Teruo

    2014-01-01

    Casimiroa edulis is known as cochitzapotl, and it belongs to a species of tropical fruiting tree in the family Rutaceae, native to eastern Mexico and Central America south to Costa Rica. In this study, we isolated two furocoumarins and two polymethoxyflavones from leaves of C. edulis and evaluated the functions of glucose and lipid metabolism activity with 3T3-L1 adipocytes. We discovered that the addition of furocoumarins increased glucose uptake and lipid accumulation in 3T3-L1 adipocyte. These results suggest that furocoumarin compounds can be used as functional food-derived compounds, to regulate adipocyte functioning for the management of metabolic syndrome, which is associated with dysfunctions of glucose and lipid metabolism. PMID:25036684

  15. "The show must go on!" Beserings van dramastudente tydens opleiding

    J Deacon

    2009-03-01

    Full Text Available "THE SHOW MUST GO ON!" LIABILITY WHEN IT COMES TO DRAMA STUDENTS WHEN INJURED WHILE IN TRAININGThis article emphasises the uncertainty in the relationship between a student undergoing practical training and his/her lecturer or university, if the student should be injured and wants to claim compensation. One must first establish whether the student can be described as an employee of the lecturer or university, or as a vocational worker or independent contractor. Once the status of the student has been established, the relevant legislation can be determined, whether it is the Labour Relations Act or the Basic Conditions of Employment. It is, however, not that simple and a person in the capacity of a student does not accord with the definition of an employee or an independent contractor or a vocational worker. One will have to rely on the assumption in section 83A in the Basic Conditions of Employment that a student is an employee when he does practical training for the benefit of the university. The Occupational Health and Safety Act requires employers to assure that the workplace is a safe environment for employees, with the minimum risks involved. The Compensation for Occupational Injuries and Diseases Act makes it possible for an employee to claim compensation when such a risk becomes a reality.This article also tries to compare the situation of a student sports person injured while participating in university sports, and a drama student injured during a performance or rehearsal of a play. It is stated that the relationship between the drama student and lecturer is similar to the relationship between a sports person and his/her coach, but the relationship differs in that a sports person’s risk of getting hurt is much greater than that of a drama student, The contracts between sports players and their authorities are also stipulated in much more detail than the contracts (if any between the drama students and the university. It is concluded that the legislation is not clear on the specific matters where a student undergoes practical training while they are still studying. The suggestion is that a sectoral determination must be put in place to regulate the relationship, the remuneration, the working hours and the working conditions and risks involved.The article is in Afrikaans.

  16. Showing that you care: the evolution of health altruism.

    Hanson, Robin

    2008-01-01

    Human behavior regarding medicine seems strange; assumptions and models that seem workable in other areas seem less so in medicine. Perhaps, we need to rethink the basics. Toward this end, I have collected many puzzling stylized facts about behavior regarding medicine, and have sought a small number of simple assumptions which might together account for as many puzzles as possible. The puzzles I consider include a willingness to provide more medical than other assistance to associates, a desire to be seen as so providing, support for nation, firm, or family provided medical care, placebo benefits of medicine, a small average health value of additional medical spending relative to other health influences, more interest in public that private signals of medical quality, medical spending as an individual necessity but national luxury, a strong stress-mediated health status correlation, and support for regulating health behaviors of the low status. These phenomena seem widespread across time and cultures. I can explain these puzzles moderately well by assuming that humans evolved deep medical habits long ago in an environment where people gained higher status by having more allies, honestly cared about those who remained allies, were unsure who would remain allies, wanted to seem reliable allies, inferred such reliability in part based on who helped who with health crises, tended to suffer more crises requiring non-health investments when having fewer allies, and invested more in cementing allies in good times in order to rely more on them in hard times. These ancient habits would induce modern humans to treat medical care as a way to show that you care. Medical care provided by our allies would reassure us of their concern, and allies would want you and other allies to see that they had pay enough to distinguish themselves from posers who didn't care as much as they. Private information about medical quality is mostly irrelevant to this signaling process. If people with fewer allies are less likely to remain our allies, and if we care about them mainly assuming they remain our allies, then we want them to invest more in health than they would choose for themselves. This tempts us to regulate their health behaviors. This analysis suggests that the future will continue to see robust desires for health behavior regulation and for communal medical care and spending increases as a fraction of income, all regardless of the health effects of these choices. PMID:17923332

  17. Anger, Cognition, Ideology: What Crash Can Show Us About Emotion

    Sue J. Kim

    2010-06-01

    Full Text Available

    Abstract (E: Sue J. Kim’s essay “Anger, Cognition, Ideology: What Crash Can Show Us About Emotion” argues for the relevance and importance of cognitive studies to ethnic and postcolonial literary studies, and vice versa. After surveying recent developments in the field of cognitive studies, the essay combines cultural and cognitive approaches in order to examine anger in and around the 2005 Paul Haggis film Crash.

     

    Abstract (F: Dans cet article, l’auteur fait un plaidoyer pour l’application des études cognitives aux études ethniques et postcoloniales et inversement. L’essai présente d’abord un survol des récents développements dans le domaine des études cognitives, puis combine les approches culturelles et cognitives dans une lecture détaillée du thème de la colère dans le film Crash de Paul Haggis (2005.

     

  18. VLA's Sharpened Vision Shows Details of Still-Forming Star

    2001-01-01

    Using a new observing capability of the National Science Foundation's Very Large Array (VLA) radio telescope, astronomers have discovered a solar-system-sized disk of gas and dust feeding material onto a young star with 8 to 10 times the mass of the Sun. This is the first time an inner "accretion disk" has been seen around such a massive star. The VLA images also revealed the inner portion of an energetic outflow of material powered by the accretion disk. Artist's conception "Disks and outflows in young stars increase dramatically in mass and energy as the mass of the young star increases. We don't know if the same process is at work in all young stars or how the disks can both power an outflow that extends more than 15 light-years and also start the process of forming planets," said Debra Shepherd, of the National Radio Astronomy Observatory (NRAO) in Socorro, New Mexico. "By studying the birth of massive young stars, we're pushing the limits of our understanding and trying to learn if there are critical differences between the outflows from high and low mass young stars," she added Shepherd and Mark Claussen, also from the NRAO in Socorro, and Stan Kurtz of the National Autonomous University in Mexico, presented their findings today at the American Astronomical Society's meeting in San Diego, CA. The scientists made the discovery using the VLA connected by a newly- operational fiber-optic link to one of the radio-telescope antennas of the NSF's Very Long Baseline Array (VLBA), located at Pie Town, NM, 32 miles away from the VLA. Linking the VLA to the Pie Town antenna almost doubled the resolving power, or ability to see fine detail, available to the astronomers. "We could not have seen these structures without using the Pie Town antenna connected to the VLA," said Claussen. Work on the VLA-Pie Town fiber-optic link, financed by the NSF and Associated Universities, Inc., which operates NRAO for the NSF, began in late 1997. The linked facilities first were available for routine astronomical observations last autumn. In late November, the scientists pointed the sharpened vision of the combined telescopes at an object called G192.16-3.82, more than 6,000 light-years distant in the constellation Orion. First observed in 1990, G192.16-3.82 was found to be a massive young star powering one of the largest stellar outflows -- extending more than 30 light years from end to end -- in the entire Milky Way Galaxy. Earlier observations showed the young star is surrounded by a large, rotating disk with a diameter greater than 1,000 times the Sun-Earth distance. Astronomers, however, believed that the outflow had to originate from a structure much smaller than this disk. The VLA-Pie Town system gave them their first glimpse of the suspected smaller structure, another disk slightly larger than our own Solar System containing enough gas and dust to make 20 Suns. In addition, they saw the inner portion of the outflow of material powered by that disk. The new observations also showed that the smaller disk probably is truncated by the gravitational pull of another, previously-unseen young star less massive than the first. Close to the larger protostar, the outflow is wide, covering an angle of about 40 degrees. "With smaller protostars, the outflow begins wide but then is narrowed down to a thin jet relatively close to its origin. However, when the protostar is more massive, the outflow tends to remain wide," Shepherd said. "We think that magnetic fields narrow down the flow from the smaller protostars. It's possible that when the flow contains much more mass, such as in this system, the magnetic fields may be just too weak in most cases to get this done," she said. "Our new observations now make it possible to test this idea by comparing computer simulations to what we see in the real universe," Shepherd said. The VLA is a system of 27 radio-telescope antennas distributed over the high desert west of Socorro, NM, in the shape of a giant "Y." Made famous in mo

  19. Exceptional dinosaur fossils show ontogenetic development of early feathers.

    Xu, Xing; Zheng, Xiaoting; You, Hailu

    2010-04-29

    Recent discoveries of feathered dinosaur specimens have greatly improved our understanding of the origin and early evolution of feathers, but little information is available on the ontogenetic development of early feathers. Here we describe an early-juvenile specimen and a late-juvenile specimen, both referable to the oviraptorosaur Similicaudipteryx, recovered from the Lower Cretaceous Yixian Formation of western Liaoning, China. The two specimens have strikingly different remiges and rectrices, suggesting that a radical morphological change occurred during feather development, as is the case for modern feathers. However, both the remiges and the rectrices are proximally ribbon-like in the younger specimen but fully pennaceous in the older specimen, a pattern not known in any modern bird. In combination with the wide distribution of proximally ribbon-like pennaceous feathers and elongate broad filamentous feathers among extinct theropods, this find suggests that early feathers were developmentally more diverse than modern ones and that some developmental features, and the resultant morphotypes, have been lost in feather evolution. PMID:20428169

  20. OGJ group earnings show big gain for 1993

    Earnings for Oil and Gas Journal's group of 22 large US oil companies advanced sharply last year, increasing 70.9% from 1992. Group profits totaled $16.1 billion, with the gain stemming largely from lack of one time charges that depressed earnings in 1992. Adoption of new accounting rules associated with future postretirement costs caused the 1992 charges. US exploration and production earnings were mixed, tied in part to oil and gas production volumes. Higher gas prices and production helped boost earnings for a number of companies. But the earnings improvement from gas was offset by reduced oil production and prices. Results from non-U.S. E and P also were mixed. Average worldwide crude oil export prices were down from year earlier levels. However, for some companies this was offset by higher production levels and lower exploration costs. Earnings from refining and marketing were improved from 1992 levels, particularly for non-US operations. Lower feedstock costs, especially in the fourth quarter, helped boost earnings in this sector. Refining earnings gains also flowed from lower costs due to restructuring and an accompanying improvement in operating efficiency. The paper discusses world trends, operations and prices, US exploration and production, non-US E and P, US and non-US refining and marketing, petrochemicals, and the forecast for future demand

  1. Replicase-based plasmid DNA shows anti-tumor activity

    Weiss Richard

    2011-03-01

    Full Text Available Abstract Background Double stranded RNA (dsRNA has multiple anti-tumor mechanisms. Over the past several decades, there have been numerous attempts to utilize synthetic dsRNA to control tumor growth in animal models and clinical trials. Recently, it became clear that intracellular dsRNA is more effective than extracellular dsRNA on promoting apoptosis and orchestrating adaptive immune responses. To overcome the difficulty in delivering a large dose of synthetic dsRNA into tumors, we propose to deliver a RNA replicase-based plasmid DNA, hypothesizing that the dsRNA generated by the replicase-based plasmid in tumor cells will inhibit tumor growth. Methods The anti-tumor activity of a plasmid (pSIN-β that encodes the sindbis RNA replicase genes (nsp1-4 was evaluated in mice with model tumors (TC-1 lung cancer cells or B16 melanoma cells and compared to a traditional pCMV-β plasmid. Results In cell culture, transfection of tumor cells with pSIN-β generated dsRNA. In mice with model tumors, pSIN-β more effectively delayed tumor growth than pCMV-β, and in some cases, eradicated the tumors. Conclusion RNA replicase-based plasmid may be exploited to generate intracellular dsRNA to control tumor growth.

  2. Asia-Pacific area shows big gains in processing

    This paper reports on the Asia-Pacific region's buoyant refining and petrochemical industries that are reacting to lessons from the Persian gulf war. First-and least palatable-is the knowledge there is no alternative to oil from the Middle East to fuel headlong economic growth. Iraq's Aug. 2, 1990, invasion of Kuwait, resulting in the loss of crude oil from both countries and the flow of products from Kuwait's sophisticated refining complexes, hammered home another valuable lesson. In a crisis, the petroleum industry-oil exporting countries in particular-will in the short term find it easier to make substitute crude supplies available than to conjure up products from alternative processing capacity. The Japanese, as might be expected, are implementing new policies to take account of this lesson. Japan's tightly controlled refining sector has been told it can expand capacity for the first time in 18 years. And, with the blessing of the Japanese government, a group of companies led by Nippon Oil has agreed to a joint venture with Saudi Arabian Oil Co. that will lead to new refining capacity in Japan and a new export refinery in Saudi Arabia that is likely to be dedicated to the Japanese market

  3. A synthetically modified hydrophobin showing enhanced fluorous affinity.

    Milani, Roberto; Pirrie, Lisa; Gazzera, Lara; Paananen, Arja; Baldrighi, Michele; Monogioudi, Evanthia; Cavallo, Gabriella; Linder, Markus; Resnati, Giuseppe; Metrangolo, Pierangelo

    2015-06-15

    Hydrophobins are natural surfactant proteins endowed with exceptional surface activity and film-forming capabilities and their use as effective "fluorine-free fluorosurfactants" has been recently reported. In order to increase their fluorophilicity further, here we report the preparation of a unique fluorous-modified hydrophobin, named F-HFBI. F-HFBI was found to be more effective than its wild-type parent protein HFBI at reducing interface tension of water at both air/water and oil/water interfaces, being particularly effective at the fluorous/water interface. F-HFBI was also found to largely retain the exceptionally good capability of forming strong and elastic films, typical of the hydrophobin family. Further studies by interface shear rheology and isothermal compression, alongside Quartz Crystal Microbalance and Atomic Force Microscopy, demonstrated the tendency of F-HFBI to form thicker films compared to the wild-type protein. These results suggest that F-HFBI may function as an effective compatibilizer for biphasic systems comprising a fluorous phase. PMID:25725398

  4. Oklahoma Cherokee formation study shows benefits of gas tax credits

    To no one's surprise, the administration's recently released energy initiative package does not advocate the use of tax incentives such as the Internal Revenue Code Sec. 29 (tight sand gas) credit that expired Dec. 31, 1992. This is unfortunate since tax credits do stimulate drilling, as the authors' recent study of Oklahoma's Pennsylvanian age Cherokee formation demonstrates. Within this 783,000 acre study area, more than 130 additional wells were drilled between 1991--92 because of tax credit incentives. And such tax credits also increase total federal tax revenues by causing wells to be drilled that would not have been drilled or accelerating the drilling of wells, thereby increasing taxable revenue. In short, tax credits create a win-win situation: they stimulate commerce, increase tax revenues, reduce the outflow of capital to foreign petroleum projects, and add to the nation's natural gas reserve, which is beneficial for national security, balance of payments, the environment, and gas market development. The paper discusses the study assumptions, study results, and the tax credit policy

  5. Genetic Data Showing Evolutionary Links between Leishmania and Endotrypanum

    Elisa Cupolillo

    1998-09-01

    Full Text Available Striking similarities at the morphological, molecular and biological levels exist between many trypanosomatids isolated from sylvatic insects and/or vertebrate reservoir hosts that make the identification of medically important parasites demanding. Some molecular data have pointed to the relationship between some Leishmania species and Endotrypanum, which has an important epidemiological significance and can be helpful to understand the evolution of those parasites. In this study, we have demonstrated a close genetic relationship between Endotrypanum and two new leishmanial species, L. (V. colombiensis and L. (V. equatorensis. We have used (a numerical zymotaxonomy and (b the variability of the internal transcribed spacers of the rRNA genes to examine relationships in this group. The evolutionary trees obtained revealed high genetic similarity between L. (V. colombiensis, L. (V. equatorensis and Endotrypanum, forming a tight cluster of parasites. Based on further results of (c minicircle kDNA heterogeneity analysis and (d measurement of the sialidase activity these parasites were also grouped together.

  6. Capuchin monkeys do not show human-like pricing effects.

    Catapano, Rhia; Buttrick, Nicholas; Widness, Jane; Goldstein, Robin; Santos, Laurie R

    2014-01-01

    Recent work in judgment and decision-making has shown that a good's price can have irrational effects on people's preferences. People tend to prefer goods that cost more money and assume that such expensive goods will be more effective, even in cases where the price of the good is itself arbitrary. Although much work has documented the existence of these pricing effects, unfortunately little work has addressed where these price effects come from in the first place. Here we use a comparative approach to distinguish between different accounts of this bias and to explore the origins of these effects. Specifically, we test whether brown capuchin monkeys (Cebus apella) are also susceptible to pricing effects within the context of an experimentally trained token economy. Using a capuchin population previously trained in a token market, we explored whether monkeys used price as an indicator of value across four experiments. Although monkeys demonstrated an understanding of which goods had which prices (consistently shifting preferences to cheaper goods when prices were increased), we observed no evidence that such price information affected their valuation of different kinds of goods. These results suggest that human pricing effects may involve more sophisticated human-unique cognitive capacities, such as an understanding of market forces and signaling. PMID:25520677

  7. Unexpected show up of incomplete fusion at low projectile energies

    Singh B.P.

    2011-10-01

    Full Text Available In this paper, some of the important findings of recent measurements performed to study incomplete fusion at low bombarding energies (i.e., Elab ≈ 4-7 MeV/nucleon in 12C, 16O+169Tm systems are briefly summarized. The spin-distributions of xn, pxn, αxn/2αxn- channels have been measured to probe entirely different γ-emission patterns (and feeding intensity profiles during the de-excitation of complete and incomplete fusion objects. Incomplete fusion strength function has been deduced (from the analysis of experimental excitation functions in context of equilibrated compound nucleus decay to achieve information of onset and strength of incomplete fusion in terms of various entrance channel parameters. Presence of incomplete fusion at slightly above barrier energies has been confirmed by the measurement of linear momentum distribution of heavy recoils. Present results conclusively demonstrate, the existence of incomplete fusion at low bombarding energies, its strong dependence on entrance channel parameters, and the possibility to populate high spin states.

  8. Global Uranium Supply Ensured for Long Term, New Report Shows

    Full text: Uranium resources and production are on the rise with the security of uranium supply ensured for the long term, according to a new report by the OECD Nuclear Energy Agency (NEA) and the International Atomic Energy Agency (IAEA). Uranium 2011: Resources, Production and Demand, commonly referred to as the ''Red Book'', shows that total identified uranium resources have grown 12.5% since 2008. However, the costs of production have also increased, leading to reductions in lower cost category resources. These figures, which reflect the situation as of 1 January 2011, mean that total identified resources are sufficient for over 100 years of supply based on current requirements. Global uranium mine production increased by over 25% between 2008 and 2010 because of significantly increased production in Kazakhstan, currently the world's leading producer. The increased resource base has been achieved thanks to a 22% increase in uranium exploration and mine development expenditures between 2008 and 2010, which in 2010 totalled over $2 billion. Demand for uranium is expected to continue to rise for the foreseeable future. Although the Fukushima Daiichi nuclear accident has affected nuclear power projects and policies in some countries, nuclear power remains a key part of the global energy mix. Several governments have plans for new nuclear power plant construction, with the strongest expansion expected in China, India, the Republic of Korea and the Russian Federation. The speed and magnitude of growth in generating capacity elsewhere is still to be determined. By the year 2035, according to the joint NEA-IAEA Secretariat, world nuclear electricity generating capacity is projected to grow from 375 GWe net (at the end of 2010) to between 540 GWe net in the low demand case and 746 GWe net in the high demand case, increases of 44% and 99% respectively. Accordingly, world annual reactor-related uranium requirements are projected to rise from 63 875 tonnes of uranium metal (tU) at the end of 2010 to between 98 000 tU and 136 000 tU by 2035. The currently defined uranium resource base is more than adequate to meet high-case requirements through 2035 and well into the foreseeable future. Although ample resources are available, meeting projected demand will require timely investments in uranium production facilities. This is because of the long lead times (typically in the order of ten years or more in most producing countries) required to develop production facilities that can turn resources into refined uranium ready for nuclear fuel production. With uranium production ready to expand to new countries, efforts are being made to develop transparent and well-regulated operations similar to those used elsewhere to minimise potential environmental and local health impacts. Although not the primary focus of the Red Book, activity updates on the environmental aspects of the uranium production cycle are included in the national reports in this edition. While the status of supply and demand is considered from the perspective of technologies in use today, the deployment of advanced reactors and fuel cycle technologies can also positively affect the long-term availability of uranium, conceivably extending the time horizon of the currently defined resource base to thousands of years. These are some of the findings in the just-published Uranium 2011: Resources, Production and Demand, a joint study by the OECD/NEA and the IAEA, carried out in co-operation with their member countries. This is the 24th edition of this periodic assessment (currently every two years) which has been published since the mid-1960s. (IAEA)

  9. Development of an SMA electrode to match type 316LN base metal cryogenic properties

    A series of shielded metal arc electrodes was fabricated and the mechanical properties of the resultant welds were measured. The compositions are based on a high Mn, high N version of a type 308 electrode, to which additional Mn, N, Ni and Mo were added. The strength was measured at 4, 76 and 298 K, and the Charpy V-notch absorbed energy was measured at 76 K. The strength of the welds matched or exceeded that strength of the base metal, but fell short of the Charpy V-notch absorbed energy. (author)

  10. Local approach of the Charpy test at low temperature

    Charpy V-notch impact testing is widely used in the toughness assessment of large forged components, e.g. the pressure vessel for pressurised water reactors (PWR). At low temperature, A508 Cl.3 nuclear pressure vessel steel fails by cleavage fracture. The results reported here are part of both an experimental program and numerical investigations which aim at the establishment of a non-empirical relationship between the lower shelf Charpy V-notch energy, CVN, and the fracture toughness, KIc, of this material. Here, the applicability of the Beremin cleavage fracture model to the Charpy specimen is demonstrated. (orig.)

  11. Milky Way a Swifter Spinner, More Massive, New Measurements Show

    2009-01-01

    Fasten your seat belts -- we're faster, heavier, and more likely to collide than we thought. Astronomers making high-precision measurements of the Milky Way say our home Galaxy is rotating about 100,000 miles per hour faster than previously understood. That increase in speed, said Mark Reid, of the Harvard-Smithsonian Center for Astrophysics, increases the Milky Way's mass by 50 percent, bringing it even with the Andromeda Galaxy. "No longer will we think of the Milky Way as the little sister of the Andromeda Galaxy in our Local Group family." Milky Way Artist's Conception of our Milky Way Galaxy: Blue, green dots indicate distance measurements. CREDIT: Robert Hurt, IPAC; Mark Reid, CfA, NRAO/AUI/NSF JPEG graphic with scale marks on sides PostScript graphic with scale marks on sides The larger mass, in turn, means a greater gravitational pull that increases the likelihood of collisions with the Andromeda galaxy or smaller nearby galaxies. Our Solar System is about 28,000 light-years from the Milky Way's center. At that distance, the new observations indicate, we're moving at about 600,000 miles per hour in our Galactic orbit, up from the previous estimate of 500,000 miles per hour. The scientists are using the National Science Foundation's Very Long Baseline Array (VLBA) radio telescope to remake the map of the Milky Way. Taking advantage of the VLBA's unparalleled ability to make extremely detailed images, the team is conducting a long-term program to measure distances and motions in our Galaxy. They reported their results at the American Astronomical Society's meeting in Long Beach, California. The scientists observed regions of prolific star formation across the Galaxy. In areas within these regions, gas molecules are strengthening naturally-occuring radio emission in the same way that lasers strengthen light beams. These areas, called cosmic masers, serve as bright landmarks for the sharp radio vision of the VLBA. By observing these regions repeatedly at times when the Earth is at opposite sides of its orbit around the Sun, the astronomers can measure the slight apparent shift of the object's position against the background of more-distant objects. "The new VLBA observations of the Milky Way are producing highly-accurate direct measurements of distances and motions," said Karl Menten of the Max Planck Institute for Radio Astronomy in Germany, a member of the team. "These measurements use the traditional surveyor's method of triangulation and do not depend on any assumptions based on other properties, such as brightness, unlike earlier studies." The astronomers found that their direct distance measurements differed from earlier, indirect measurements, sometimes by as much as a factor of two. The star-forming regions harboring the cosmic masers "define the spiral arms of the Galaxy," Reid explained. Measuring the distances to these regions thus provides a yardstick for mapping the Galaxy's spiral structure. "These direct measurements are revising our understanding of the structure and motions of our Galaxy," Menten said. "Because we're inside it, it's difficult for us to determine the Milky Way's structure. For other galaxies, we can simply look at them and see their structure, but we can't do this to get an overall image of the Milky Way. We have to deduce its structure by measuring and mapping," he added. The VLBA can fix positions in the sky so accurately that the actual motion of the objects can be detected as they orbit the Milky Way's center. Adding in measurements of motion along the line of sight, determined from shifts in the frequency of the masers' radio emission, the astronomers are able to determine the full 3-dimensional motions of the star-forming regions. Using this information, Reid reported that "most star-forming regions do not follow a circular path as they orbit the Galaxy; instead we find them moving more slowly than other regions and on elliptical, not circular, orbits." The researchers attribute this to what they call spiral density wave shocks, which can take gas in a circular orbit, compress i

  12. Recent results from AMY

    Recent results from the AMY detector at TRISTAN are reported. It was found that the application of new radiative correction on the hadronic R reduces the discrepancy between measured value and the Standard Model (SM) prediction. The total cross sections of ?+?- and ?+?- channels show poor consistency with the SM prediction. The values of the QCD parameter ?MS (and equivalently ?3) were obtained using several methods, and they are consistent with each other. The photon structure function F2? was measured and compared with theoretical calculations based on QCD. For hadron production in quasi-real two-photon collision, we observed excess events over the expectation of the sum of the quark-parton model (QPM) and the vector-meson dominance model (VMD), and we show this excess can be explained by hard scattering of the hadronic constituents of the photons. (author)

  13. News Note: Screening for ovarian cancer shows no reduction in mortality

    Simultaneous screening with a blood test for the biomarker CA-125 along with a transvaginal ultrasound (TVU), compared with usual care, did not reduce ovarian cancer mortality in American women. These results, from a National Cancer Institute (NCI) sponsored trial, also show that diagnostic evaluation following a false-positive result was associated with potentially harmful complications.

  14. The Influence of Heat Treatment on the Microstructure and Machinability of a Prehardened Mold Steel

    Hoseiny, Hamed; Caballero, Francisca G.; M'Saoubi, Rachid; Hgman, Berne; Weidow, Jonathan; Andrn, Hans-Olof

    2015-05-01

    The machinability performance of a modified AISI P20 steel, heat treated to have the same hardness but three different microstructures, lower bainite, tempered martensite, and primary spheroidized carbides in a tempered martensite matrix, was studied. The microstructures were characterized using light optical and scanning electron microscopy and X-ray diffraction, and mechanical properties were compared by means of tensile and Charpy V-notch impact tests. The influence of microstructure and the resultant mechanical properties on machinability was studied in the context of single tooth end milling operation. The results showed that the material containing primary spheroidized carbides exhibited a superior machinability at the expense of a marginal loss of tensile strength and impact toughness, with comparable yield strength to that of the material containing tempered martensite. By contrast, the material with bainitic microstructure showed the lowest yield strength and the poorest machinability performance while having the highest uniform elongation.

  15. Pressure locking test results

    The U.S. Nuclear Regulatory Commission (NRC), Office of Nuclear Regulatory Research, is funding the Idaho National Engineering Laboratory (INEL) in performing research to provide technical input for their use in evaluating responses to Generic Letter 95-07, open-quotes Pressure Locking and Thermal Binding of Safety-Related Power-Operated Gate Valves.close quotes Pressure locking and thermal binding are phenomena that make a closed gate valve difficult to open. This paper discusses only the pressure locking phenomenon in a flexible-wedge gate valve; the authors will publish the results of their thermal binding research at a later date. Pressure locking can occur when operating sequences or temperature changes cause the pressure of the fluid in the bonnet (and, in most valves, between the discs) to be higher than the pressure on the upstream and downstream sides of the disc assembly. This high fluid pressure presses the discs against both seats, making the disc assembly harder to unseat than anticipated by the typical design calculations, which generally consider friction at only one of the two disc/seat interfaces. The high pressure of the bonnet fluid also changes the pressure distribution around the disc in a way that can further contribute to the unseating load. If the combined loads associated with pressure locking are very high, the actuator might not have the capacity to open the valve. The results of the NRC/INEL research discussed in this paper show that the relationship between bonnet pressure and pressure locking stem loads appears linear. The results also show that for this valve, seat leakage affects the bonnet pressurization rate when the valve is subjected to thermally induced pressure locking conditions

  16. Pressure locking test results

    DeWall, K.G.; Watkins, J.C.; McKellar, M.G.; Bramwell, D. [Idaho National Engineering Lab., Idaho Falls, ID (United States)] [and others

    1996-12-01

    The U.S. Nuclear Regulatory Commission (NRC), Office of Nuclear Regulatory Research, is funding the Idaho National Engineering Laboratory (INEL) in performing research to provide technical input for their use in evaluating responses to Generic Letter 95-07, {open_quotes}Pressure Locking and Thermal Binding of Safety-Related Power-Operated Gate Valves.{close_quotes} Pressure locking and thermal binding are phenomena that make a closed gate valve difficult to open. This paper discusses only the pressure locking phenomenon in a flexible-wedge gate valve; the authors will publish the results of their thermal binding research at a later date. Pressure locking can occur when operating sequences or temperature changes cause the pressure of the fluid in the bonnet (and, in most valves, between the discs) to be higher than the pressure on the upstream and downstream sides of the disc assembly. This high fluid pressure presses the discs against both seats, making the disc assembly harder to unseat than anticipated by the typical design calculations, which generally consider friction at only one of the two disc/seat interfaces. The high pressure of the bonnet fluid also changes the pressure distribution around the disc in a way that can further contribute to the unseating load. If the combined loads associated with pressure locking are very high, the actuator might not have the capacity to open the valve. The results of the NRC/INEL research discussed in this paper show that the relationship between bonnet pressure and pressure locking stem loads appears linear. The results also show that for this valve, seat leakage affects the bonnet pressurization rate when the valve is subjected to thermally induced pressure locking conditions.

  17. Comportamento agressivo em shows musicais: analisando notícias de jornal impresso

    Carlos Eduardo Pimentel

    2011-08-01

    Full Text Available This paper reports a content analysis of the newspaper articles dealing with aggressive behavior in music shows. This analysis permits an understanding of the characteristics of these situations, the aggressive behaviors in shows, and the way in which the print media treat the subject. Despite of the newspapers’ influence on public opinion formation, that is, the transmission of attitudes and behavior repertoires, this kind of analysis is rarely reported in Brazilian social psychological literature. Some 31 newspaper articles were content analyzed as to aggressive behavior during music shows. Results indicate that aggressive behaviors occur in shows of most varied musical styles. Results are discussed on the basis of social cognitive theory.

  18. New and Old Results in Resultant Theory

    Morozov, A.; Shakirov, Sh.

    2009-01-01

    Resultants are getting increasingly important in modern theoretical physics: they appear whenever one deals with non-linear (polynomial) equations, with non-quadratic forms or with non-Gaussian integrals. Being a subject of more than three-hundred-year research, resultants are of course rather well studied: a lot of explicit formulas, beautiful properties and intriguing relationships are known in this field. We present a brief overview of these results, including both recent and already class...

  19. VRAC: Simulation Results #1

    Huc, Florian

    2009-01-01

    In order to make full use of geographic routing techniques developed for large scale networks, nodes must be localized. However, localization and virtual localization techniques in sensor networks are dependent either on expensive and sometimes unavailable hardware (e.g. GPS) or on sophisticated localization calculus (e.g. triangulation) which are both error-prone and with a costly overhead. Instead of localizing nodes in a traditional 2-dimensional space, we use directly the raw distance to a set of anchors to route messages in a multi-dimensional space. This should enable us to use any geographic routing protocol in a robust and efficient manner in a very large range of scenarios. We test this technique for two different geographic routing algorithms, namely GRIC and ROAM. The simulation results show that using the raw coordinates does not decrease their efficiency.

  20. Consumer behavior towards show-room services of two wheelers with reference to Cuddalore district

    S.Pragadeeswaran

    2009-12-01

    Full Text Available The study aims to find out the consumer behavior towards showroom service of two wheelers. A samples of 200 users selected randomly were studied. Standardized questionnaires were used to collect the data. The results reveal that users differ in consumer behaviour towards showroom services of two wheelers on the basis of satisfied random sampling. This study is made to describe the consumer satisfaction of two wheelers with respect to socio-economic characteristics as age, gender, occupation, family income, educational level and so on which is called descriptive study. The data were treated statistically using t-test, F-test and correlation. The result shows that students and employees are more satisfied about show room services. Demographic variables such as marital status, size of the family give significant effect related to show room services.

  1. Suffering by comparison: Twitter users' reactions to the Victoria's Secret Fashion Show.

    Chrisler, Joan C; Fung, Kaitlin T; Lopez, Alexandra M; Gorman, Jennifer A

    2013-09-01

    Social comparison theory suggests that evaluating the self in comparison with others (e.g., peers, celebrities, models) can influence body image. Experimental studies that have tested effects of viewing idealized images in the media often show that women feel worse about themselves after seeing images that illustrate the beauty ideal. Twitter presents a naturally occurring opportunity to study viewers' reactions. An analysis was conducted of 977 tweets sent immediately before and during the 2011 Victoria's Secret Fashion Show that reference the show. Although the majority were idiosyncratic remarks, many tweets contain evidence of upward social comparisons to the fashion models. There were tweets about body image, eating disorders, weight, desires for food or alcohol, and thoughts about self-harm. The results support social comparison theory, and suggest that vulnerable viewers could experience negative affect, or even engage in harmful behaviors, during or after viewing the show or others like it. PMID:23769929

  2. Musical slide show MAF with protection and governance using MPEG-21 IPMP Components and REL

    Sabirin, Muhammad Syah Houari; Tan, Hendry; Lim, Jeongyeon; Kim, Munchurl

    2007-02-01

    The Musical Slide Show Multimedia Application Format (MAF) which is currently being standardized by the Moving Picture Expert Group (MPEG) conveys the concept of combining several established standard technologies in a single file format. It defines the format of packing up MP3 audio data, along with JPEG images, MPEG-7 Simple Profile metadata, timed text, and MPEG-4 LASeR script. The presentation of Musical Slide Show MAF contents is made in a synchronized manner with JPEG images, timed text to MP3 audio track. Also, the rendering effect on JPEG images can be supported by the MPEG-4 LASeR script. This Musical Slide Show MAF will enrich the consumption of MP3 contents assisted with synchronized and rendered JPEG images, text as well as MPEG-7 metadata about the MP3 audio contents. However, there is no protection and governance mechanism for Musical Slide Show MAF which is the essential elements to deploy the sorts of contents. In this paper, to manage the Musical Slide Show MAF contents in a controlled manner, we present a protection and governance mechanism by using MPEG-21 Intellectual Property Management and Protection (IPMP) Components and MPEG-21 Rights Expression Language (REL) technologies We implement an authoring tool and a player tool for Musical Slide Show MAF contents and show the experimental results as well.

  3. Report on Results 2000

    NONE

    2001-07-01

    This report discusses work being carried out in Norway to promote energy efficiency and the production of new renewable energy. An overall review of the quantifiable results of last year's activities at national level is available. It will serve to initiate an annual reporting tradition. The report represents a step towards an ongoing process for improved targeting and management of national efforts. During the course of the year 2000, NVE has evaluated and adjusted its activities and established a system involving indicators and reporting procedures. It is also important to take notice of the long-term work being undertaken to influence people's attitudes, even though this work is difficult to assess. NVE is investing in i.a. measures aimed at children and young people. Apart from directly influencing future energy users, this investment is also having an effect due to the children's encouragement of their parents to engage in more energy and environment-friendly behaviour. Published in 2000, the IEA report ''Trends in Norwegian Stationary Energy Use'' shows that total Norwegian energy consumption per GDP is not much higher than in other IEA countries, when adjusted for cold climate and industrial structure. However, Norwegians do stand out as intensive users of electricity. The IEA report shows a reduction of 10 TWh in energy usage when compared to the projected post 1990 figures. Energy efficiency activities have contributed towards this reduction. However, the potential for a more rational use of energy in Norway is still substantial and well documented. Based on experience most enterprises could save around 10% of energy used just by making changes to their operations, i.e. without major investments. Furthermore, the potential is growing because of massive technological developments in respect of energy usage, production and distribution. With this in mind, it is necessary to take full advantage of the extensive knowledge base regarding new renewable energy sources that is available through Nordic cooperation. During the course of the year a new energy body will be established to assume responsibility for initiatives encouraging more rational energy usage and more environment-friendly energy production. When this energy body commences operations next year, it will have a solid foundation on which to build further. It will inherit a well-founded system and an efficient structure. The results achieved during the year 2000 show savings in energy efficiency and the production of new renewable energy of 720 GWh. The gains could be even greater with clearly defined target-driven management. Due to internationalisation, Norway now has to deal with problems to which little attention was previously paid. All energy production has negative environmental co sequences. It is becoming increasingly obvious that we all need to contribute to limiting the damaging effects, while at the same time the international community needs to take the initiative in harmonizing measures which can result in a more sustainable and environment-friendly direction.

  4. Areva - 2011 Annual results

    Areva's backlog established at 45.6 billion euros at the end of 2011, significantly increasing at the end of a year marked by the Fukushima accident, confirms the commercial dynamism of the group alongside its customers and reinforces the visibility on its future business level. In a difficult context, the slight decline in revenue in 2011 demonstrates the robustness of Areva's integrated model, resting mainly on recurring business generated in relation to Areva's customers' nuclear installed base, and benefiting from the development of Areva's renewable energies operations. Free operating cash flow before tax, although down over the whole year in 2011, improved in the second half, showing the first effects of Areva's stronger focus on cash generation and debt management. After the success of Areva's bond issue in September 2011, the Group's liquidity remains high at the end of 2011. The Areva teams are now dedicating all of their efforts to the deployment of the 'Action 2016' strategic action plan, which had already yielded its first positive results at the end of 2011, with an improvement in the cost structure of Areva's operations, an increase in order intake, and the launch of several disposals of minority interests. Summary of the 2011 financial results: - Backlog: euro 45.6 bn, +3.1% vs. 2010, i.e +6.7% over 3 months; - Revenue: euro 8.872 bn, i.e -2.6% vs. 2010; - Operating income: - euro 1.923 bn; - Net income attributable to equity owners of the parent: - euro 2.424 bn; - EBITDA: euro 1.068 bn ( euro 420 m excluding Siemens impact); - Free operating cash flow before tax: - euro 2.397 bn (- euro 1.366 bn excluding Siemens impacts), improvement over the second half; - Decrease in net debt of euro 124 m for the year; - Significant drop in general and administrative expenses, with a noticeable reduction between the first and the second half; - Launch of several disposals of minority interests

  5. Showing and telling: using tablet technology to engage students in mathematics

    Ingram, Naomi; Williamson-Leadley, Sandra; Pratt, Keryn

    2016-03-01

    This paper reports on a qualitative investigation into the use of Show and Tell tablet technology in mathematics classrooms. A Show and Tell application (app) allows the user to capture voice and writing or text in real time. Described here are the perceptions of 11 teachers during and after their exploration into the use of Show and Tell in their primary and secondary classrooms. These perceptions were used to evaluate Show and Tell tablet technology against a framework of student engagement and effective pedagogy. The results of the study indicated that the teachers perceived both the level and the quality of the students' engagement were high. Using Show and Tell apps enabled the teachers to enact effective pedagogy within their classroom practices. Importantly, through the use of Show and Tell recordings, students' thinking became visible to themselves, their teachers and other students in the class. This thinking then formed the basis of robust discussions and negotiation about the mathematical concepts and the strategies the students used to solve problems.

  6. BIOMETRICAL ANALYSIS OF ARABIAN FOALS AND THEIR LATER SUCCESSES IN SHOWS AND ON RACE TRACK

    M. PIESZKA

    2013-12-01

    Full Text Available Arabian horses are one of the most important products of Polish horse breeding.Many of them are International and World champions in shows; others are very wellknown as courageous race horses. To obtain such champions it is necessary to takeunder consideration many factors affecting the final results. The objective of thisstudy was to evaluate the effect of biometrical measurements of the foals at birthaccording to their future successes in shows and on racetrack. The study was carriedout on 143 horses winning in shows and in races. Body weight, height at withers,girth and canon circumferences taken at birth of these horses were analysed.Additionally coat colour was studied. All studied animals were divided into threegroups according to each measurement and the differences between such groupswere evaluated according points obtained for particular place at shows and place inraces. It was stated that horses heavier at birth and with higher girth circumferencegot more successes both at shows and on racetrack. Horses with higher height atwithers at birth were more successful in shows while animals with higher canoncircumference won oftener at race track. It was observed that the most courageousrace horses were bay while most champions were grey.

  7. Results from LHCf Experiment

    Tricomi Alessia

    2012-06-01

    Full Text Available The LHCf experiment has taken data in 2009 and 2010 p-p collisions at LHC at √s = 0.9 TeV and √s = 7 TeV. The measurement of the forward neutral particle spectra produced in proton-proton collisions at LHC up to an energy of 14 TeV in the center of mass system are of fundamental importance to calibrate the Monte Carlo models widely used in the high energy cosmic ray (HECR field, up to an equivalent laboratory energy of the order of 1017 eV. In this paper the first results on the inclusive photon spectrum measured by LHCf is reported. Comparison of this spectrum with the model expectations show significant discrepancies, mainly in the high energy region. In addition, perspectives for future analyses as well as the program for the next data taking period, in particular the possibility to take data in p-Pb collisions, will be discussed.

  8. The Effect of Constant and Pulsed Current Gas Tungsten Arc Welding on Joint Properties of 2205 Duplex Stainless Steel to 316L Austenitic Stainless Steel

    Neissi, R.; Shamanian, M.; Hajihashemi, M.

    2016-04-01

    In this study, dissimilar 316L austenitic stainless steel/2205 duplex stainless steel (DSS) joints were fabricated by constant and pulsed current gas tungsten arc welding process using ER2209 DSS as a filler metal. Microstructures and joint properties were characterized using optical and electron scanning microscopy, tensile, Charpy V-notch impact and micro-hardness tests, and cyclic polarization measurements. Microstructural observations confirmed the presence of chromium nitride and delta ferrite in the heat-affected zone of DSS and 316L, respectively. In addition, there was some deviation in the austenite/ferrite ratio of the surface welding pass in comparison to the root welding pass. Besides having lower pitting potential, welded joints produced by constant current gas tungsten arc welding process, consisted of some brittle sigma phase precipitates, which resulted in some impact energy reduction. The tensile tests showed high tensile strength for the weld joints in which all the specimens were broken in 316L base metal.

  9. Estimation of Fracture Toughness Degradation of High Temperature Materials by Nonlinear Acoustic Effects

    In order to develop an ultrasonic evaluation method for properties degradation of high temperature materials, a number of Cr-Mo-V steel samples were heat-treated and their damage mechanism was examined. Ultrasonic parameters such as velocity, attenuation, and more recently developed nonlinear acoustic parameter were measured. The nonlinear acoustic parameter was found to be most sensitive to material degradation mainly attributed to the precipitation of impurities in grain boundaries. When compared to the electrical resistivity results, the nonlinear parameters showed similar behavior. There existed a relatively good correlation between the nonlinear parameter and the fracture appearance transition temperature (FATT) obtained by Charpy V-notch impact test. Based on the relationship between the FATT and the fracture toughness (KIC), correlation between the nonlinear parameter and KIC was established

  10. Verification of the effect of surface preparation on Hot Isostatic Pressing diffusion bonding joints of CLAM steel

    Zhao, Yanyun; Li, Chunjing; Huang, Bo; Liu, Shaojun; Huang, Qunying

    2014-12-01

    Hot Isostatic Pressing (HIP) diffusion bonding with CLAM steel is the primary candidate fabrication technique for the first wall (FW) of DFLL-TBM. Surface state is one of the key factors for the joints quality. The effect of surface state prepared with grinder and miller on HIP diffusion bonding joints of CLAM steel was investigated. HIP diffusion bonding was performed at 140 MPa and 1373 K within 3 h. The mechanical properties of the joints were investigated with instrumented Charpy V-notch impact tests and the microstructures of the joints were analyzed with scanning electron microscopy (SEM). The results showed that the milled samples with fine surface roughness were more suitable for CLAM steel HIP diffusion bonding.

  11. Verification of the effect of surface preparation on Hot Isostatic Pressing diffusion bonding joints of CLAM steel

    Zhao, Yanyun [University of Science and Technology of China, Hefei, Anhui 230027 (China); Institute of Nuclear Energy Safety Technology, Chinese Academy of Sciences, Hefei, Anhui 230031 (China); Li, Chunjing, E-mail: chunjing.li@fds.org.cn [Institute of Nuclear Energy Safety Technology, Chinese Academy of Sciences, Hefei, Anhui 230031 (China); Huang, Bo; Liu, Shaojun [Institute of Nuclear Energy Safety Technology, Chinese Academy of Sciences, Hefei, Anhui 230031 (China); Huang, Qunying [University of Science and Technology of China, Hefei, Anhui 230027 (China); Institute of Nuclear Energy Safety Technology, Chinese Academy of Sciences, Hefei, Anhui 230031 (China)

    2014-12-15

    Hot Isostatic Pressing (HIP) diffusion bonding with CLAM steel is the primary candidate fabrication technique for the first wall (FW) of DFLL-TBM. Surface state is one of the key factors for the joints quality. The effect of surface state prepared with grinder and miller on HIP diffusion bonding joints of CLAM steel was investigated. HIP diffusion bonding was performed at 140 MPa and 1373 K within 3 h. The mechanical properties of the joints were investigated with instrumented Charpy V-notch impact tests and the microstructures of the joints were analyzed with scanning electron microscopy (SEM). The results showed that the milled samples with fine surface roughness were more suitable for CLAM steel HIP diffusion bonding.

  12. Verification of the effect of surface preparation on Hot Isostatic Pressing diffusion bonding joints of CLAM steel

    Hot Isostatic Pressing (HIP) diffusion bonding with CLAM steel is the primary candidate fabrication technique for the first wall (FW) of DFLL-TBM. Surface state is one of the key factors for the joints quality. The effect of surface state prepared with grinder and miller on HIP diffusion bonding joints of CLAM steel was investigated. HIP diffusion bonding was performed at 140 MPa and 1373 K within 3 h. The mechanical properties of the joints were investigated with instrumented Charpy V-notch impact tests and the microstructures of the joints were analyzed with scanning electron microscopy (SEM). The results showed that the milled samples with fine surface roughness were more suitable for CLAM steel HIP diffusion bonding

  13. Degradation of impact fracture during accelerated aging of weld metal on microalloyed steel

    The effect of accelerated aging on the toughness and fracture of the longitudinal weld metal on an API5L-X52 line pipe steel was evaluated by Charpy V-notch impact test, fracture analysis and transmission electron microscopy. Aging was performed at 250 degree centigrade for 100 to 1000 h. The impact results indicated a significant reduction in the fracture energy and impact toughness as a function of aging time, which were achieved by the scanning electron microscope fractography that showed a decrease in the vol fraction of microvoids by Charpy ductile failure with the aging time, which favored the brittle fracture by transgranular cleavage. The minimum vol fraction of microvoids was reached at 500 h due to the peak aged. The microstructural analysis indicated the precipitation of transgranular iron nano carbides in the aged specimens, which was related to the deterioration of toughness and change in the ductile to brittle behavior. (Author) 15 refs

  14. Degradation of impact fracture during accelerated aging of weld metal on microalloyed steel; Degradacion de la tenacidad al impacto durante el envejecimiento acelerado de soldadura en acero microaleado

    Vargas-Arista, B.; Hallen, J. M.; Albiter, A.; Angeles-Chavez, C.

    2008-07-01

    The effect of accelerated aging on the toughness and fracture of the longitudinal weld metal on an API5L-X52 line pipe steel was evaluated by Charpy V-notch impact test, fracture analysis and transmission electron microscopy. Aging was performed at 250 degree centigrade for 100 to 1000 h. The impact results indicated a significant reduction in the fracture energy and impact toughness as a function of aging time, which were achieved by the scanning electron microscope fractography that showed a decrease in the vol fraction of microvoids by Charpy ductile failure with the aging time, which favored the brittle fracture by transgranular cleavage. The minimum vol fraction of microvoids was reached at 500 h due to the peak aged. The microstructural analysis indicated the precipitation of transgranular iron nano carbides in the aged specimens, which was related to the deterioration of toughness and change in the ductile to brittle behavior. (Author) 15 refs.

  15. Overview of MAST results

    Chapman, I. T.; Adamek, J.; Akers, R. J.; Allan, S.; Appel, L.; Asunta, O.; Barnes, M.; Ben Ayed, N.; Bigelow, T.; Boeglin, W.; Bradley, J.; Brnner, J.; Cahyna, P.; Carr, M.; Caughman, J.; Cecconello, M.; Challis, C.; Chapman, S.; Chorley, J.; Colyer, G.; Conway, N.; Cooper, W. A.; Cox, M.; Crocker, N.; Crowley, B.; Cunningham, G.; Danilov, A.; Darrow, D.; Dendy, R.; Diallo, A.; Dickinson, D.; Diem, S.; Dorland, W.; Dudson, B.; Dunai, D.; Easy, L.; Elmore, S.; Field, A.; Fishpool, G.; Fox, M.; Fredrickson, E.; Freethy, S.; Garzotti, L.; Ghim, Y. C.; Gibson, K.; Graves, J.; Gurl, C.; Guttenfelder, W.; Ham, C.; Harrison, J.; Harting, D.; Havlickova, E.; Hawke, J.; Hawkes, N.; Hender, T.; Henderson, S.; Highcock, E.; Hillesheim, J.; Hnat, B.; Holgate, J.; Horacek, J.; Howard, J.; Huang, B.; Imada, K.; Jones, O.; Kaye, S.; Keeling, D.; Kirk, A.; Klimek, I.; Kocan, M.; Leggate, H.; Lilley, M.; Lipschultz, B.; Lisgo, S.; Liu, Y. Q.; Lloyd, B.; Lomanowski, B.; Lupelli, I.; Maddison, G.; Mailloux, J.; Martin, R.; McArdle, G.; McClements, K.; McMillan, B.; Meakins, A.; Meyer, H.; Michael, C.; Militello, F.; Milnes, J.; Morris, A. W.; Motojima, G.; Muir, D.; Nardon, E.; Naulin, V.; Naylor, G.; Nielsen, A.; O'Brien, M.; O'Gorman, T.; Ono, Y.; Oliver, H.; Pamela, S.; Pangione, L.; Parra, F.; Patel, A.; Peebles, W.; Peng, M.; Perez, R.; Pinches, S.; Piron, L.; Podesta, M.; Price, M.; Reinke, M.; Ren, Y.; Roach, C.; Robinson, J.; Romanelli, M.; Rozhansky, V.; Saarelma, S.; Sangaroon, S.; Saveliev, A.; Scannell, R.; Schekochihin, A.; Sharapov, S.; Sharples, R.; Shevchenko, V.; Silburn, S.; Simpson, J.; Storrs, J.; Takase, Y.; Tanabe, H.; Tanaka, H.; Taylor, D.; Taylor, G.; Thomas, D.; Thomas-Davies, N.; Thornton, A.; Turnyanskiy, M.; Valovic, M.; Vann, R.; Walkden, N.; Wilson, H.; Wyk, L. V.; Yamada, T.; Zoletnik, S.; MAST; MAST Upgrade Teams

    2015-10-01

    The Mega Ampre Spherical Tokamak (MAST) programme is strongly focused on addressing key physics issues in preparation for operation of ITER as well as providing solutions for DEMO design choices. In this regard, MAST has provided key results in understanding and optimizing H-mode confinement, operating with smaller edge localized modes (ELMs), predicting and handling plasma exhaust and tailoring auxiliary current drive. In all cases, the high-resolution diagnostic capability on MAST is complemented by sophisticated numerical modelling to facilitate a deeper understanding. Mitigation of ELMs with resonant magnetic perturbations (RMPs) with toroidal mode number nRMP = 2, 3, 4, 6 has been demonstrated: at high and low collisionality; for the first ELM following the transition to high confinement operation; during the current ramp-up; and with rotating nRMP = 3 RMPs. nRMP = 4, 6 fields cause less rotation braking whilst the power to access H-mode is less with nRMP = 4 than nRMP = 3, 6. Refuelling with gas or pellets gives plasmas with mitigated ELMs and reduced peak heat flux at the same time as achieving good confinement. A synergy exists between pellet fuelling and RMPs, since mitigated ELMs remove fewer particles. Inter-ELM instabilities observed with Doppler backscattering are consistent with gyrokinetic simulations of micro-tearing modes in the pedestal. Meanwhile, ELM precursors have been strikingly observed with beam emission spectroscopy (BES) measurements. A scan in beta at the L-H transition shows that pedestal height scales strongly with core pressure. Gyro-Bohm normalized turbulent ion heat flux (as estimated from the BES data) is observed to decrease with increasing tilt of the turbulent eddies. Fast ion redistribution by energetic particle modes depends on density, and access to a quiescent domain with classical fast ion transport is found above a critical density. Highly efficient electron Bernstein wave current drive (1 A W-1) has been achieved in solenoid-free start-up. A new proton detector has characterized escaping fusion products. Langmuir probes and a high-speed camera suggest filaments play a role in particle transport in the private flux region whilst coherence imaging has measured scrape-off layer (SOL) flows. BOUT++ simulations show that fluxes due to filaments are strongly dependent on resistivity and magnetic geometry of the SOL, with higher radial fluxes at higher resistivity. Finally, MAST Upgrade is due to begin operation in 2016 to support ITER preparation and importantly to operate with a Super-X divertor to test extended leg concepts for particle and power exhaust.

  16. Serum muscle-derived enzymes response during show jumping competition in horse

    Assenza, Anna; Marafioti, Simona; Congiu, Fulvio; Giannetto, Claudia; Fazio, Francesco; Bruschetta, Daniele; Piccione, Giuseppe

    2016-01-01

    Aim: The effect of two jumping competitions, performed in two consecutive weekends, on serum creatine phosphokinase (CPK), aspartate aminotransferase (AST), and lactate dehydrogenase (LDH), urea, creatinine (CREA) concentrations were evaluated in 12 healthy jumper horses. Materials and Methods: Blood sampling was performed before the 1st day of competition (T0), at the end of each show (J1, J2), on the day after the competition (T1); the same sampling plan was followed during the second weekend (J3, J4 and T2). Results: One-way repeated measures analysis of variance showed an increase in CPK at J1 and J2 respect to T0 and at J3 and J4 respect to all other time points (pmuscle recovery and avoid potential additional stress. The findings obtained in this study improve the knowledge about metabolic changes occurring in athlete horse during the competition to identify muscle alterations following show jumping competitions. PMID:27057107

  17. Effects of coronary artery bypass surgery on regions showing persistent defects in thallium myocardial images

    The indications for revascularization surgery and its effects on myocardial regions showing persistent defects in thallium myocardial images are controversial. The effects of aortocoronary bypass surgery on myocardial perfusion and wall motion in the regions with persistent defects were evaluated in 47 patients with thallium-201 single photon emission computed tomography and left ventriculography. In areas showing persistent thallium defects preoperatively the rate of improvement of perfusion was only 24% by postoperative thallium imaging, and 57% by wall motion analysis. These results were significantly inferior to those of regions with transient defects, which were 84% and 82%, respectively. A persistent defect may not be a definitive marker of a non-viable scar, but the results of surgery on such regions were unsatisfactory. It is concluded, therefore, that revascuralization surgery in regions with persistent defects is not always recommended and that the indications for surgery should be individually determined with operative risk balanced against benefits. (author)

  18. Brain morphometry shows effects of long-term musical practice in middle-aged keyboard players

    HannaGärtner

    2013-09-01

    Musicians showed a significantly better symmetric motor performance as well as a greater capability of controlling hand independence than controls. Structural MRI-data revealed significant volumetric differences between the brains of keyboard players, who practiced intensively and controls in right sensorimotor areas and the corticospinal tract as well as in the entorhinal cortex and the left superior parietal lobule. Moreover, they showed also larger volumes in a comparable set of regions than the less intensively practicing musicians. The structural changes in the sensory and motor systems correspond well to the behavioral results, and can be interpreted in terms of plasticity as a result of intensive motor training. Areas of the superior parietal lobule and the entorhinal cortex might be enlarged in musicians due to their special skills in sight-playing and memorizing of scores. In conclusion, intensive and specific musical training seems to have an impact on brain structure, not only during the sensitive period of childhood but throughout life.

  19. Crack/cocaine users show more family problems than other substance users

    Moura, Helena Ferreira; Benzano, Daniela; Pechansky, Flavio; Kessler, Felix Henrique Paim

    2014-01-01

    OBJECTIVES: To evaluate family problems among crack/cocaine users compared with alcohol and other substance users. METHODS: A cross-sectional multi-center study selected 741 current adult substance users from outpatient and inpatient Brazilian specialized clinics. Subjects were evaluated with the sixth version of the Addiction Severity Index, and 293 crack users were compared with 126 cocaine snorters and 322 alcohol and other drug users. RESULTS: Cocaine users showed more family problems whe...

  20. Mice lacking desmocollin 1 show epidermal fragility accompanied by barrier defects and abnormal differentiation

    Chidgey, M; Brakebusch, C; Gustafsson, E; Cruchley, A; Hail, C; Kirk, S; Merritt, A; North, A; Tselepis, C; Hewitt, J; Byrne, C; Fassler, R; Garrod, D

    2001-01-01

    The desmosomal cadherin desmocollin (Dsc)1 is expressed in upper epidermis where strong adhesion is required. To investigate its role in vivo, we have genetically engineered mice with a targeted disruption in the Dsc1 gene. Soon after birth, null mice exhibit flaky skin and a striking punctate ep...... blistering diseases is discussed. These results show that Dsc1 is required for strong adhesion and barrier maintenance in epidermis and contributes to epidermal differentiation....

  1. Entropy Calculation of Reversible Mixing of Ideal Gases Shows Absence of Gibbs Paradox

    Oleg Borodiouk; Vasili Tatarin

    1999-01-01

    Abstract: We consider the work of reversible mixing of ideal gases using a real process. Now assumptions were made concerning infinite shifts, infinite number of cycles and infinite work to provide an accurate calculation of entropy resulting from reversible mixing of ideal gases. We derived an equation showing the dependence of this entropy on the difference in potential of mixed gases, which is evidence for the absence of Gibbs' paradox.

  2. Porn video shows, local brew, and transactional sex: HIV risk among youth in Kisumu, Kenya

    Voeten Helene ACM; Njue Carolyne; Remes Pieter

    2011-01-01

    Abstract Background Kisumu has shown a rising HIV prevalence over the past sentinel surveillance surveys, and most new infections are occurring among youth. We conducted a qualitative study to explore risk situations that can explain the high HIV prevalence among youth in Kisumu town, Kenya Methods We conducted in-depth interviews with 150 adolescents aged 15 to 20, held 4 focus group discussions, and made 48 observations at places where youth spend their free time. Results Porn video shows a...

  3. Material properties characterization of low carbon steel using TBW and PWHT techniques in smooth-contoured and U-shaped geometries

    This paper investigates the effects of the temper bead welding (TBW) technique and post weld heat treatment (PWHT) on mechanical properties of multi-layer welding on low carbon steel specimens using Charpy V-notch impact testing and tensile testing. Several samples of two different weld geometries, viz. (i) smooth-contoured, and (ii) U-shaped were made with multiple bead layers using both TBW and PWHT techniques. Impact testing showed that at room temperature and below, TBW gave an impact toughness in the Heat Affected Zone (HAZ) better than both PWHT and the parent material. At temperatures higher than the room temperature but below 60 °C, PWHT gave better impact toughness in the HAZ. Above 60 °C, both TBW and PWHT showed impact toughness lower than that of the parent material. In tensile testing, both TBW and PWHT weld metal specimens produced acceptable results; however, TBW gave yield and tensile strengths closer to that of the actual material than PWHT. -- Highlights: • Effects of post weld heat treatment (PWHT) and temper bead welding (TBW) on properties are tested. • Charpy V-notch impact and tensile testing was performed on multi-layer welding of low carbon steel. • At room temperature and below, TBW gave better impact toughness than both PWHT and parent material. • Above room temperature but below 60 °C, PWHT gave better impact toughness than TBW. • Above 60 °C, both TBW and PWHT showed impact toughness lower than that of parent material

  4. Examination of parameters affecting overload fracture behavior of flaw-tip hydrides in Zr-2.5Nb pressure tubes in Candu reactors

    Service-induced flaws in Zr-2.5Nb alloy pressure tubes in Candu (Canada Deuterium Uranium Reactors) nuclear reactors are susceptible to a crack initiation and growth mechanism known as Delayed Hydride Cracking (DHC), which is a repetitive process that involves hydrogen diffusion, hydride precipitation, growth and fracture of a hydride region at the flaw-tip under a constant load. Crack initiation may also occur under another loading condition when the hydride region is subjected to an overload. An overload occurs when the hydride region at the flaw tip is loaded to a stress higher than that at which this region is formed such as when the reactor experiences a transient pressure higher than the normal operating pressure where the hydride region is formed. Flaw disposition requires justification that the hydride region overload will not fracture the hydride region, and initiate DHC. In this work, monotonically increasing load experiments were performed on unirradiated Zr-2.5Nb pressure tube specimens containing simulated debris frets (V-notch) and bearing pad frets (BPF, U-shape notch) to examine overload fracture behavior of flaw-tip hydrides formed under hydride ratcheting conditions. Hydride cracking in the overload tests was detected by the acoustic emission technique and confirmed by post-test metallurgical examination. Test results indicate that the resistance to overload fracture is affected by a number of parameters including hydride formation stress, flaw shape (V-notch vs. BPF) and flaw radius (0.015 mm vs. 0.1 mm). The notch-tip hydride morphologies were examined by optical microscopy and scanning electron microscopy (SEM) which show that they are affected by the hydride formation conditions, resulting in different overload fracture resistance. Finite element stress analyses were also performed to obtain flaw-tip stress distributions for interpretation of the test results. (authors)

  5. The information seeking and procurment needs of attendees at an industrial trade show

    N. C. Bresler

    2009-12-01

    Full Text Available Purpose: The purpose of this article is to describe what attracts visitors to an industrial trade show, and to profile them. This will enable the show organisers to attract the right mix of exhibitors and fulfil their dual role of satisfying the needs of both attendees and exhibitors and improve the role of exhibitions in the latter's marketing mix. Problem investigated: The research seeks to elicit the attendance objectives of participants in order to ascertain their information seeking and procurement needs. This can be used to improve the marketing communication of both the organisers and exhibitors. Research methodology: The research design is a multi method, descriptive study. A non probability, judgemental sample was drawn; 1020 interviews were conducted per Electra Mining Africa expo in 2004 and 2006. Both open ended and fixed response questions were posed and due to the similarity of responses, 300 per show were analysed. The researcher fulfilled a participant observer role to enhance the validity and reliability of the findings. Findings/implications: The prime reason for visitation was to see what is new, discover, and gather information, and attendees were not disappointed in that. The trade shows attracted an informed, niche audience. Exhibitors gained access to key decision makers with buying influence. Attendees represented all roles in the buying process and intended to buy some capital items exhibited within the following year. Business contacts were made. The attraction and contact efficiency of the exhibition's were high and may result in conversion efficiency. In terms of market and geographical coverage it is a vertical international show. Originality: This paper contributes to limited research conducted on trade shows, especially in South Africa. It is unique in that it describes the effectiveness of an industrial trade show from a demand perspective in order to improve the facilitating role of exhibition organisers. It develops a knowledge base for improved show participation and future comparative studies. Conclusion: For effective communication to take place exhibitors need to align their objectives with those of attendees. Organisers must provide exhibitors with a profile of expected visitors to enhance their performance and improve show participation.

  6. School-Aged Children and Adult Language Production in an Indonesian TV Show

    Kisno

    2014-03-01

    Full Text Available The aim of this research was to find out the language produced by the school-aged children and the adult in a TV show. The study was carried out applying descriptive qualitative research design. The data for this research included the conversations between an adult (the host and three school-aged children. The data analysis procedures included- observing the video, transcribing the conversation, identifying the linguistics and non-linguistics features of the utterances, categorizing the language produced by the children and the adult, and interpreting the result of the analysis. The findings of data analysis showed that the five-year-old children produced one-word and two-word utterances rather than longer sentences. In contrast, the seven-year-old child produced longer sentences rather than one-word or two-word utterances. On the other hand, the host applied different ways and modified the way she produced language (‘caregiver speech’ or ‘motherese’ such as using exclamation, using gestures, using complimenting words, using intimate pronouns, and using direct instruction. The results obtained indicated that the school-aged children and the adult have their own ways in producing language in a TV show in Indonesia.

  7. Alzheimer's-associated A? oligomers show altered structure, immunoreactivity and synaptotoxicity with low doses of oleocanthal

    It now appears likely that soluble oligomers of amyloid-?1-42 peptide, rather than insoluble fibrils, act as the primary neurotoxin in Alzheimer's disease (AD). Consequently, compounds capable of altering the assembly state of these oligomers (referred to as ADDLs) may have potential for AD therapeutics. Phenolic compounds are of particular interest for their ability to disrupt A? oligomerization and reduce pathogenicity. This study has focused on oleocanthal (OC), a naturally-occurring phenolic compound found in extra-virgin olive oil. OC increased the immunoreactivity of soluble A? species, when assayed with both sequence- and conformation-specific A? antibodies, indicating changes in oligomer structure. Analysis of oligomers in the presence of OC showed an upward shift in MW and a ladder-like distribution of SDS-stable ADDL subspecies. In comparison with control ADDLs, oligomers formed in the presence of OC (A?-OC) showed equivalent colocalization at synapses but exhibited greater immunofluorescence as a result of increased antibody recognition. The enhanced signal at synapses was not due to increased synaptic binding, as direct detection of fluorescently-labeled ADDLs showed an overall reduction in ADDL signal in the presence of OC. Decreased binding to synapses was accompanied by significantly less synaptic deterioration assayed by drebrin loss. Additionally, treatment with OC improved antibody clearance of ADDLs. These results indicate oleocanthal is capable of altering the oligomerization state of ADDLs while protecting neurons from the synaptopathological effects of ADDLs and suggest OC as a lead compound for development in AD therapeutics.

  8. Using television shows to teach communication skills in internal medicine residency

    Ma Irene

    2009-02-01

    Full Text Available Abstract Background To address evidence-based effective communication skills in the formal academic half day curriculum of our core internal medicine residency program, we designed and delivered an interactive session using excerpts taken from medically-themed television shows. Methods We selected two excerpts from the television show House, and one from Gray's Anatomy and featured them in conjunction with a brief didactic presentation of the Kalamazoo consensus statement on doctor-patient communication. To assess the efficacy of this approach a set of standardized questions were given to our residents once at the beginning and once at the completion of the session. Results Our residents indicated that their understanding of an evidence-based model of effective communication such as the Kalamazoo model, and their comfort levels in applying such model in clinical practice increased significantly. Furthermore, residents' understanding levels of the seven essential competencies listed in the Kalamazoo model also improved significantly. Finally, the residents reported that their comfort levels in three challenging clinical scenarios presented to them improved significantly. Conclusion We used popular television shows to teach residents in our core internal medicine residency program about effective communication skills with a focus on the Kalamazoo's model. The results of the subjective assessment of this approach indicated that it was successful in accomplishing our objectives.

  9. Differential gene expression of two extreme honey bee (Apis mellifera) colonies showing varroa tolerance and susceptibility.

    Jiang, S; Robertson, T; Mostajeran, M; Robertson, A J; Qiu, X

    2016-06-01

    Varroa destructor, an ectoparasitic mite of honey bees (Apis mellifera), is the most serious pest threatening the apiculture industry. In our honey bee breeding programme, two honey bee colonies showing extreme phenotypes for varroa tolerance/resistance (S88) and susceptibility (G4) were identified by natural selection from a large gene pool over a 6-year period. To investigate potential defence mechanisms for honey bee tolerance to varroa infestation, we employed DNA microarray and real time quantitative (PCR) analyses to identify differentially expressed genes in the tolerant and susceptible colonies at pupa and adult stages. Our results showed that more differentially expressed genes were identified in the tolerant bees than in bees from the susceptible colony, indicating that the tolerant colony showed an increased genetic capacity to respond to varroa mite infestation. In both colonies, there were more differentially expressed genes identified at the pupa stage than at the adult stage, indicating that pupa bees are more responsive to varroa infestation than adult bees. Genes showing differential expression in the colony phenotypes were categorized into several groups based on their molecular functions, such as olfactory signalling, detoxification processes, exoskeleton formation, protein degradation and long-chain fatty acid metabolism, suggesting that these biological processes play roles in conferring varroa tolerance to naturally selected colonies. Identification of differentially expressed genes between the two colony phenotypes provides potential molecular markers for selecting and breeding varroa-tolerant honey bees. PMID:26919127

  10. Retroviral DNA Integration: ASLV, HIV, and MLV Show Distinct Target Site Preferences

    Mitchell Rick S

    2004-01-01

    Full Text Available The completion of the human genome sequence has made possible genome-wide studies of retroviral DNA integration. Here we report an analysis of 3,127 integration site sequences from human cells. We compared retroviral vectors derived from human immunodeficiency virus (HIV, avian sarcoma-leukosis virus (ASLV, and murine leukemia virus (MLV. Effects of gene activity on integration targeting were assessed by transcriptional profiling of infected cells. Integration by HIV vectors, analyzed in two primary cell types and several cell lines, strongly favored active genes. An analysis of the effects of tissue-specific transcription showed that it resulted in tissue-specific integration targeting by HIV, though the effect was quantitatively modest. Chromosomal regions rich in expressed genes were favored for HIV integration, but these regions were found to be interleaved with unfavorable regions at CpG islands. MLV vectors showed a strong bias in favor of integration near transcription start sites, as reported previously. ASLV vectors showed only a weak preference for active genes and no preference for transcription start regions. Thus, each of the three retroviruses studied showed unique integration site preferences, suggesting that virus-specific binding of integration complexes to chromatin features likely guides site selection.

  11. Recent results from TRISTAN

    TRISTAN results on ?? physics from 1994 to 1995 are reviewed in this report. We have systematically investigated jet production, the ?-structure function, and charm pair production in ?? processes. The results are discussed, and future prospects are presented

  12. Influence of baffle configurations on flow and heat transfer characteristics of trisection helical baffle heat exchangers

    Highlights: • Nephograms with velocity-vector superimposed are proposed on special slices. • Single vortex secondary flow and shortcut leakage patterns are clearly depicted. • Local heat transfer coefficient field and average value on tubes are presented. • Circumferential overlap scheme performs best over other schemes. - Abstract: Numerical simulation of flow and heat transfer characteristics in four trisection helical baffle heat exchangers with equilateral triangle tube layouts was conducted. The heat exchangers have the same helical pitch but four different baffle shapes or connections, i.e., a circumferential overlap (CO) scheme, an end-to-end (EE) scheme, a blocked V-notches (BV) scheme, and a middle axial overlap (MO) scheme. The single vortex secondary flow in each helical cycle and the leakage flow patterns in the V-notches of the adjacent baffles of these schemes are clearly depicted on the meridian slices and unfolded hexagon slices. The results for nine tubes in a 60° sector and four tube layers reveal that the local heat transfer coefficient of the center tube is much higher than that of the other tubes for all the schemes. The results show that the CO scheme has the highest shell-side heat transfer coefficient and comprehensive indexes, the BV scheme has the highest pressure drop and the worst comprehensive indexes, and the MO scheme has the lowest values of both shell-side heat transfer coefficient and pressure drop and the second highest comprehensive indexes. The average values of comprehensive index ho/Δpo of CO scheme in the calculated range is respectively 16.5%, 27.3% and 13.5% higher than that of the EE, BV and MO schemes

  13. Grain size and temperature influence on the toughness of a CuAlBe shape memory alloy

    Research highlights: → This work evaluated the capacity of a CuAlBe alloy to absorb energy until rupture. → The V-notch Charpy test was adopted at -150, -100, -50, 0, 50, 100 and 150 deg. C. → Charpy tests were complemented by DSC, DSC with optical microscope and by SEM. → First work to analyze the toughness of a CuAlBe alloy based on the Charpy test. → The results are of relevant value to enhance the understanding of the CuAlBe alloy. - Abstract: This work is a study of the influence of grain size and temperature on the toughness of CuAlBe shape memory alloys with (CuAlBeNbNi) and without NbNi (CuAlBe) grain refiner elements. The toughness analysis was based on the V-notch Charpy impact test under temperatures of -150, -100, -50, 0, 50, 100 and 150 deg. C. A statistical analysis of the results led to the conclusion that the toughness of both alloys was influenced by temperature and grain size. The CuAlBeNbNi alloy absorbed higher impact energy than the CuAlBe alloy showing that the refining elements improved the toughness of the alloy. To confirm and complement these findings, the fracture surfaces were evaluated by stereomicroscopy. Smooth homogeneous surfaces and rough heterogonous surfaces were detected for the CuAlBeNbNi and CuAlBe alloys, respectively. Predominately brittle zones were confirmed by scanning electron microscopy in both alloys. Furthermore, to determine the phase transformation temperatures and the associated microstructures, the alloys were assessed by conventional differential scanning calorimetry (DSC) and DSC with optical microscopy.

  14. Your Kidney Test Results

    ... Program Name: Chronic Kidney Disease (CKD) Tests Serum Creatinine and Estimated Glomerular Filtration Rate (eGFR) Results CKD is an eGFR less than 60 Your Serum Creatinine Result: Your eGFR Result: Urine Albumin-to-Creatinine ...

  15. A Case of Budd-Chiari Syndrome Which Shows Space Occupying Lesion on Liver Scan

    Lee, Jeong Hae; Lee, Youn Ha; Seo, Dae Won; Jang, Tae Jong; Hwang, In Shup; Kim, Young Jung; Kim, So Yon; Lee, Gwon Jun [National Police Hospital, Seoul (Korea, Republic of)

    1994-10-15

    A twenty-one-year old man visited our hospital due to abdominal distension for a month. On the physical examination, there was severe abdominal distension with fluctuation and shifting dullness. The routine laboratory results were within normal range. On the Magnetic Resonance angiography, there wasn't any blood flow within the right and middle hepatic vein. So we concluded that the etiologic disease was Budd Chiari syndrome. On the liver scan, there was cold area (absence of radiouptake) on entire right lobe of the liver, increased uptake on the bone marrow and showed splenomegaly. This finding was similar to the liver mass occupying right lobe with underlying chronic liver disease. On the previous reports, it is quite uncommon finding that Budd-Chirari syndrome shows lesion like space occupying one on the liver scan. So we report this case with a review of the literature.

  16. Synthesis of a novel 99mTc nitrido radiopharmaceutical with isopropyl xanthate, showing brain uptake

    In the present study, isopropyl xanthate (IPXT) ligand was labeled with the [99mTc?N]2+ core successfully to obtain the 99mTcN(IPXT)2 complex with high radiochemical purity. No decomposition of the complex at room temperature was observed over a period of 6 h. Its partition coefficient indicated that it was a good lipophilic complex. The electrophoresis results showed that the complex was neutral. Biodistribution in mice demonstrated that the complex accumulated in the brain with high uptake and good retention. The brain uptake (ID%/g) was 1.95, 1.58 and 1.86 at 5-, 30- and 60-min post-injection, respectively. As compared with other reported 99mTcN-xanthates, the 99mTcN(IPXT)2 complex showed higher brain uptake and better brain retention, suggesting potential usefulness of the complex as a brain perfusion imaging agent

  17. Incentive program decreases no-shows in nontreatment substance abuse research.

    Pollastri, Alisha R; Pokrywa, Melyssa L; Walsh, Stephen J; Kranzler, Henry R; Gelernter, Joel

    2005-11-01

    This study examined the use of a low-cost incentive program to decrease the rate of unanticipated no-shows in a nontreatment study of the genetics of substance dependence. Low-cost retail items (such as calling cards or gift certificates) were offered contingent on attendance at the first scheduled research appointment. Although the intervention did not result in an increase in the rate of attendance at appointments, it reduced the likelihood of unanticipated no-shows by almost 50%. This reduction was accompanied by a significant increase in advance cancellations. Despite limitations due to the study's A-B design, this research demonstrates that it may be possible to use modest incentives to increase the efficiency of research enrollment and increase service provision for substance abusers. PMID:16366768

  18. Non-specific Inflammatory Disease Showed Abnormal FDG Uptake in Lower Extremities

    Including malignancy, various disease can show abnormal uptake in bone marrow.1,2) We report a case of non-specific inflammatory FDG uptake in bone marrow mimicking malignancy. A 35-year old woman with fever of unknown origin (FUO) underwent 18F-FDG PET/CT to find out fever focus and unknown malignancy. 18F-FDG was injected and imaged 1hr after injection with Discovery ST (GE, USA). 18F-FDG PET/CT whole body image showed abnormal uptake in lower extremities. MRI and biopsy was also done in the sites of abnormal uptake. PET and MRI suspect malignancy, but biopsy result was non-specific inflammatory process. The patient was improved her clinical condition after antibiotics therapy

  19. A boy infant with sleep related rhythmic movement disorder showing arm banging

    Kohyama, Jun; Takano, Tomoyuki

    2014-01-01

    Objective To present a male patient who performed arm banging on his face during sleep every night since 7 months of age. Methods Clinical course of this patient with electroencephalographic recording with video recording at 23 months of age was shown. Results His arm banging began at the age of 7 months and showed no complete remission at the age of 57 months of age, although clonazepam revealed mild effects on its intensity and frequency. Discussion We diagnosed him as having arm banging type of sleep related rhythmic movement disorder. To our knowledge, no precise description on this type of sleep related rhythmic movement disorder has been found. In addition, this patient seemed to be the youngest case of sleep related rhythmic movement disorder showing arm banging. PMID:26483925

  20. Adaptively evolved yeast mutants on galactose show trade-offs in carbon utilization on glucose

    Hong, Kuk-Ki; Nielsen, Jens

    2013-01-01

    improvement of galactose utilization were found maintained during growth on glucose. Moreover, glucose repression related genes showed conserved expression patterns during growth on both sugars. Mutations in the RAS2 gene that were identified as beneficial for galactose utilization in evolved mutants......Adaptive evolution offers many opportunities in metabolic engineering; however, several constraints still exist as evolutionary trade-offs may impose collateral cost to obtain new traits. The application of adaptive evolution for strains development could be further improved by elucidating the...... molecular mechanisms. In this study, adaptively evolved yeast mutants with improved galactose utilization ability showed impaired glucose utilization. The molecular genetic basis of this trade-off was investigated using a systems biology approach. Transcriptional and metabolic changes resulting from the...

  1. LINE-1 methylation shows little intra-patient heterogeneity in primary and synchronous metastatic colorectal cancer

    Matsunoki Aika

    2012-12-01

    Full Text Available Abstract Background Long interspersed nucleotide element 1 (LINE-1 hypomethylation is suggested to play a role in the progression of colorectal cancer (CRC. To assess intra-patient heterogeneity of LINE-1 methylation in CRC and to understand its biological relevance in invasion and metastasis, we evaluated the LINE-1 methylation at multiple tumor sites. In addition, the influence of stromal cell content on the measurement of LINE-1 methylation in tumor tissue was analyzed. Methods Formalin-fixed paraffin-embedded primary tumor tissue was obtained from 48 CRC patients. Matched adjacent normal colon tissue, lymph node metastases and distant metastases were obtained from 12, 18 and 7 of these patients, respectively. Three different areas were microdissected from each primary tumor and included the tumor center and invasive front. Normal mucosal and stromal cells were also microdissected for comparison with the tumor cells. The microdissected samples were compared in LINE-1 methylation level measured by multicolor MethyLight assay. The assay results were also compared between microdissected and macrodissected tissue samples. Results LINE-1 methylation within primary tumors showed no significant intra-tumoral heterogeneity, with the tumor center and invasive front showing identical methylation levels. Moreover, no difference in LINE-1 methylation was observed between the primary tumor and lymph node and distant metastases from the same patient. Tumor cells showed significantly less LINE-1 methylation compared to adjacent stromal and normal mucosal epithelial cells. Consequently, LINE-1 methylation was significantly lower in microdissected samples compared to macrodissected samples. A trend for less LINE-1 methylation was also observed in more advanced stages of CRC. Conclusions LINE-1 methylation shows little intra-patient tumor heterogeneity, indicating the suitability of its use for molecular diagnosis in CRC. The methylation is relatively stable during CRC progression, leading us to propose a new concept for the association between LINE-1 methylation and disease stage.

  2. A spatial model showing differences between juxtacrine and paracrine mutual oocyte-granulosa cells interactions.

    Saadeldin, Islam M; Elsayed, Asmaa; Kim, Su Jin; Moon, Joon Hu; Lee, Byeong Chun

    2015-02-01

    The bidirectional communication between oocytes and granulosa cells are mediated by several factors via a local feedback loop(s). The current model was carried out to study the spatial mutual interaction of porcine denuded oocytes and granulosa cells either in direct contact (juxtacrine) or paracrine co-culture using transwell system. Transwell 0.4 μm polyester membrane inserts were used to permit oocytes-granulosa cells paracrine communication with a distance of 2 mm between them in co-culture. Oocytes were cultured with granulosa cells in a defined basic maturation medium for 44 h. In results, oocyte secreted factors (OSFs; GDF9 and BMP15) temporal expression showed progressive decrement by the end of culture in case of direct contact with granulosa cells while it was increased progressively in the paracrine co-culture groups. However, oocytes that were cultured in direct contact showed a significant increase in blastocyst development after parthenogenetic activation than the paracrine co-cultured ones (20% vs. 11.5%, respectively). By the end of culture, granulosa cell count in direct contact showed a significant decrease than the indirect co-culture group (1.2 x 105 cell/mL vs. 2.1 x 10(5) cell/mL, respectively). Steroids (P4 and E2) and steriodogenesis enzymes mRNA levels showed significant temporal alterations either after 22 h and 44 h of IVM in both juxtacrine and paracrine co-culture systems (P ≤ 0.05). CX43 was much more highly expressed in the granulosa of the direct contact group than the indirect co-culture group. These results indicate the difference in mutual communication between oocytes and granulosa cells that were cocultured either in direct contact (juxtacrine) or with a short distance (paracrine) and propose a new paradigm to study different ovarian follicular cells interaction. PMID:25757237

  3. Cells exposed to a huntingtin fragment containing an expanded polyglutamine tract show no sign of ion channel formation: results arguing against the ion channel hypothesis

    Nørremølle, Anne; Grunnet, Morten; Hasholt, Lis; Sørensen, Sven Asger

    2003-01-01

    tract to form ion channels in two cell types. Whole cell current from Xenopus oocytes was recorded using two-electrode voltage-clamp technique, and whole cell current from CHO-K1 cells was recorded by patch-clamp technique. The fragment with an expanded polyglutamine sequence induced no change in the...

  4. Bosutinib shows low cross intolerance, in chronic myeloid leukemia patients treated in fourth line. Results of the Spanish compassionate use program.

    Garca-Gutirrez, Valentn; Martinez-Trillos, Alejandra; Lopez Lorenzo, Jose Luis; Bautista, Guiomar; Martin Mateos, Maria Luisa; Alvarez-Larrn, Alberto; Iglesias Prez, Ana; Romo Collado, Andrs; Fernandez, Angeles; Portero, Angeles; Cuevas, Beatriz; Ruiz, Concepcin; Romero, Esperanza; Ortega, Fernando; Mata, Isabel; Talln, Jos; Garca Garay, Maria Del Carmen; Ramirez Snchez, Mara Jos; de Las Heras, Natalia; Giraldo, Pilar; Bobillo, Sabela; Guinea, Jos Mara; Deben, Guillermo; Valencia, Sandra; Sebrango, Ana; Boqu, Concepcin; Maestro, Begoa; Steegmann, Juan Luis

    2015-05-01

    The role of bosutinib as rescue treatment of Philadelphia chromosome-positive chronic myeloid leukemia (CML) patients after failing three previous tyrosine kinase inhibitors (TKIs) is currently unknown. We report here the largest series (to our knowledge) of patients treated with bosutinib in fourth-line, after retrospectively reviewing 30 patients in chronic phase, and pretreated with imatinib, nilotinib, and dasatinib. With a median follow up of 11.1 months, the probability to either maintain or improve their CCyR response was 56.6% (17/30) and 11 patients (36.7%) achieved or maintained their baseline MMR. In patients not having baseline CCyR, the probabilities of obtaining CCyR, MMR, and MR4.5 were 13, 11, and 14%, respectively. The probabilities of obtaining MMR and deep molecular response MR4.5 in patients with baseline CCyR were 40.0% (6/15) and 20.0% (3/15). At 20 months, progression-free survival was 73%. Grade 3-4 hematological toxicities were more frequent in resistant than intolerant patients (45.4 vs. 0.0%). Nonhematological toxicities were also more frequent in resistant patients, being diarrhea the most conspicuous one. Bosutinib seems to be an appropriate treatment option for patients resistant or intolerant to three prior TKI's. PMID:25683327

  5. A small charge for a big result: The case of M&S shows that choice can encourage positive environmental behaviour

    Le Grand, Julian; Disney, Kate

    2011-01-01

    Encouraging individuals to change their behaviour towards the environment is an increasingly important area of policy-making. Julian Le Grand and Kate Disney find that the introduction of a charge for plastic bags in Marks and Spencer shops successfully encouraged pro-environmental behaviour and explore the implications for environmental policy.

  6. Analysis of Gentilly-2 pump trip tests showing the effect of electrical forces on pump rundown

    The objective of this paper is to present SOPHT-G2/MiniSOPHT-G2 simulation results of two tests involving the primary pump P4 rundown at Gentilly-2 when the reactor was at very low power. The first test was a primary heat transport pump P4 trip conducted during the 2001 scheduled shutdown by opening the pump breaker. The second test is a slow power transfer from the main service transformer to the standby transformer of electric bus D06 supplying P4 performed during the 2001 restart. The first test is used to validate the SOPHT-G2 pump rundown model particularly in the first two seconds. The simulation results of the instrumented channels using MiniSOPHT-G2 show that the overall trends are well reproduced. The comparison between the SOPHT-G2 simulation results with the pump trip test and the slow power transfer test results shows that the pump rundown is just slightly faster for the power transfer test. In addition, taking into account the initial conditions before each test (i.e, primary system at 57oC for pump trip test and 175oC for power transfer test), the difference in the pump rundown time is significant. This effect can be important in some loss of class IV power events where a faster pump rundown can result in a higher power excursion due to additional void generation by comparison to pump rundown due to an opening of the pump breaker. (author)

  7. Magnetite, a model system for mixed-valence oxides, does not show charge ordering

    We have investigated the charge ordering (CO) in magnetite below the Verwey transition. A new set of half-integer and mixed-integer superlattice reflections of the low-temperature phase have been studied by x-ray resonant scattering. None of these reflections show features characteristic of CO. We demonstrate the absence of CO along the c axis with the periodicity of either the cubic lattice q=(001) or the doubled cubic lattice q=(001/2). This result suggests that the Verwey transition is caused by strong electron-phonon interaction instead of an electronic ordering on the octahedral Fe atoms

  8. Genetic connections between dressage and show-jumping horses in Dutch Warmblood horses

    Rovere, Gabriel; Madsen, Per; Norberg, Elise; van Arendonk, Johan A M

    2014-01-01

    During the last decades, the breeding practice within the Dutch Warmblood studbook (KWPN) has resulted in an increasing specialisation of horses into show-jumping (JH) and dressage (DH). The objective of this study was to describe the effect of the specialisation on the connectedness between the...... subpopulations of JH and DH horses registered by KWPN. The subpopulations comprised 23,800 JH horses and 18,125 DH horses, born between 1995 and 2009. Genetic similarity (GS), genetic pool in common (GCx) based on the marginal genetic contribution of common ancestors and coefficient of relationship (r) between...

  9. A CASE OF POLYCYTHEMIA SHOWING HYPERDENSE CEREBRAL VESSELS ON NON-CONTRAST COMPUTED TOMOGRAPHY SCAN

    Bijit Kr

    2015-12-01

    Full Text Available Polycythemia is a disease state in which the proportion of blood volume that is occupied by red blood cells increases. It can result in increased density of intracranial blood vessels on non-contrast computed tomography scan. This imaging findings can closely mimic appearance of a contrast enhanced CT scan and those of cerebral venous thrombosis. We are presenting a case of 11-year-old child with Fallot’s tetralogy who showed abnormally hyperdense intracranial vessels on NCCT of brain.

  10. Individual grain orientations and texture development of nanocrystalline electrodeposits showing abnormal grain growth

    Klement, Uta [Department of Materials and Manufacturing Technology, Chalmers University of Technology, SE-41296 Gothenburg (Sweden)]. E-mail: uta.klement@chalmers.se; Silva, Melina da [Department of Materials and Manufacturing Technology, Chalmers University of Technology, SE-41296 Gothenburg (Sweden)

    2007-05-31

    The electron backscatter diffraction (EBSD) technique has been used to determine grain orientations of abnormally grown grains in nanocrystalline Ni electrodeposits upon annealing. The results show that the first grown grains have a <3 1 1>//ND orientation. Upon annealing further grain growth occurs and the preferred alignment of the abnormally growing grains changes from <3 1 1>//ND to <1 1 1>//ND. The subgrain coalescence model adopted from recrystallization is used to describe the occurrence of abnormal grain growth, and energy considerations are put forward for explaining the dominance of the <1 1 1>//ND texture component after longer annealing treatments.

  11. Customer interruption cost and results

    Eua-Arporn, B.; Bisarnbutra, S. [Chulalongkorn Univ., Bangkok (Thailand)

    1997-12-31

    Results of a comprehensive study on short-term direct impacts and consumer interruption costs, incurred as a result of power supply interruption, were discussed. The emphasis was on questionnaire development, general responses and the average customer damage function of some selected sectors. The customer damage function was established for each category of customers (agriculture, industry, mining, wholesale, retail merchandising, residential, etc) as well as for different locations. Results showed that the average customer damage function depended mostly on customer category. Size and location were not significant factors. 5 refs., 7 tabs.

  12. Total 2004 results

    NONE

    2005-02-01

    This document presents the 2004 results of Total Group: consolidated account, special items, number of shares, market environment, adjustment for amortization of Sanofi-Aventis merger-related intangibles, 4. quarter 2004 results (operating and net incomes, cash flow), upstream (results, production, reserves, recent highlights), downstream (results, refinery throughput, recent highlights), chemicals (results, recent highlights), Total's full year 2004 results (operating and net income, cash flow), 2005 sensitivities, Total SA parent company accounts and proposed dividend, adoption of IFRS accounting, summary and outlook, main operating information by segment for the 4. quarter and full year 2004: upstream (combined liquids and gas production by region, liquids production by region, gas production by region), downstream (refined product sales by region, chemicals), Total financial statements: consolidated statement of income, consolidated balance sheet (assets, liabilities and shareholder's equity), consolidated statements of cash flows, business segments information. (J.S.)

  13. Total 2004 results

    This document presents the 2004 results of Total Group: consolidated account, special items, number of shares, market environment, adjustment for amortization of Sanofi-Aventis merger-related intangibles, 4. quarter 2004 results (operating and net incomes, cash flow), upstream (results, production, reserves, recent highlights), downstream (results, refinery throughput, recent highlights), chemicals (results, recent highlights), Total's full year 2004 results (operating and net income, cash flow), 2005 sensitivities, Total SA parent company accounts and proposed dividend, adoption of IFRS accounting, summary and outlook, main operating information by segment for the 4. quarter and full year 2004: upstream (combined liquids and gas production by region, liquids production by region, gas production by region), downstream (refined product sales by region, chemicals), Total financial statements: consolidated statement of income, consolidated balance sheet (assets, liabilities and shareholder's equity), consolidated statements of cash flows, business segments information. (J.S.)

  14. Overview of ALICE results

    Ortiz, Antonio

    2015-01-01

    The ALICE detector was designed to study the physics of matter under extreme conditions of high energy density. Different results were reported by the experiment using data from the successful run I of the LHC. The goal of the present work is to present an overview of recent ALICE results. This comprises selected results from several analyses of pp, p-pb and Pb-Pb data at the LHC energies.

  15. The Arising of Results

    Sobisch, Jan-Ulrich

    2013-01-01

    Some Buddhist scholars have periodized the expected lifetime of the Buddha's teachings. According to them, these periods of 500 years each have different characteristics. The first is called 'the period of the results'. Therefore some scholars have claimed that only in the first 500 years after the...... Buddha results can arise. Kyobpa Jigten Sumgön has argued that results arise through practise as long as Dharma and Sangha exist....

  16. Results from SAGE

    We report the results of 11 years of solar neutrino observation by the Russian-American Gallium solar neutrino Experiment (SAGE). The overall result of 84 runs during the measurement period January 1990 through March 2001 is 75.6 +5.9/-5.8 (stat.) +3.5/-3.0 (syst.) SNU. This represents only slightly more than half of the predicted standard solar model rate of 129 SNU. The individual results of each run, as well as the results of combined analysis of all runs are presented

  17. Preliminary analysis showed country-specific gut resistome based on 1267 feces samples.

    Yang, Zhenyu; Guo, Zhirong; Qiu, Chuangzhao; Li, Yinhu; Feng, Xin; Liu, Yanhong; Zhang, Yanlin; Pang, Pengyu; Wang, Ping; Zhou, Qian; Han, Lijuan; Dai, Wenkui

    2016-05-01

    Gut microbiota (GM) plays an important role in drug metabolism and absorption. Ever-increasing antibiotic use could result in high accumulation of antibiotic resistance genes (ARGs) in GM, which will reduce the recovery rate of many infectious diseases. The foci of this study is to unravel ARG distribution in GM of 1267 subjects from four countries in three continents, by annotation with ARDB (Antibiotic Resistance Genes Database) and ARG-ANNOT database. Analysis results showed that all three continents had similar ARG composition, but Chinese had the highest ARG relative abundance, followed by American and European. This is possibly attributed to delayed policies on antibiotic use in China, and restrict legislation in Europe. Delivery time and application scope are proportional to ARG enrichment in GM. Findings in this study indicate that ARG accumulation could be associated with government policies on antibiotic use, and corresponding delivery time and application scope, which will be a significant reference to control antibiotic abuse. PMID:26827794

  18. De determination of quartz samples showing falling De(t) plots

    To determine an equivalent dose (De), the initial signal of the CW-OSL decay curve, supposedly dominated by the fast component, is used. Previous studies suggest that the resulting De however, may be underestimated if thermally unstable medium or slow components are part of the initial decay curve. The De(t) plot has the potential to reveal the 'unclean' fast component. We have here studied quartz samples obtained from late Pleistocene floodplain deposits in the Lower Mississippi Valley (LMV), which show decreasing values of De with increasing stimulation time. The deconvolution analysis of CW-OSL signals from these samples confirm the interpretation of the De(t) plots. As a consequence, component-resolved values of De were determined to obtain an accurate estimation of De. Contrary to previous studies, our results indicate that the values of De obtained with the initial signal are not underestimated for our samples containing a thermally unstable medium component.

  19. Lithium inclusion in indium metal-organic frameworks showing increased surface area and hydrogen adsorption

    Mathieu Bosch

    2014-12-01

    Full Text Available Investigation of counterion exchange in two anionic In-Metal-Organic Frameworks (In-MOFs showed that partial replacement of disordered ammonium cations was achieved through the pre-synthetic addition of LiOH to the reaction mixture. This resulted in a surface area increase of over 1600% in {Li [In(1,3 − BDC2]}n and enhancement of the H2 uptake of approximately 275% at 80 000 Pa at 77 K. This method resulted in frameworks with permanent lithium content after repeated solvent exchange as confirmed by inductively coupled plasma mass spectrometry. Lithium counterion replacement appears to increase porosity after activation through replacement of bulkier, softer counterions and demonstrates tuning of pore size and properties in MOFs.

  20. Lithium inclusion in indium metal-organic frameworks showing increased surface area and hydrogen adsorption

    Bosch, Mathieu; Zhang, Muwei; Feng, Dawei; Yuan, Shuai; Wang, Xuan [Department of Chemistry, Texas A and M University, College Station, Texas 77842 (United States); Chen, Ying-Pin [Department of Materials Science and Engineering, Texas A and M University, College Station, Texas 77842 (United States); Zhou, Hong-Cai, E-mail: zhou@mail.chem.tamu.edu [Department of Chemistry, Texas A and M University, College Station, Texas 77842 (United States); Department of Materials Science and Engineering, Texas A and M University, College Station, Texas 77842 (United States)

    2014-12-01

    Investigation of counterion exchange in two anionic In-Metal-Organic Frameworks (In-MOFs) showed that partial replacement of disordered ammonium cations was achieved through the pre-synthetic addition of LiOH to the reaction mixture. This resulted in a surface area increase of over 1600% in (Li [In(1,3 − BDC){sub 2}]){sub n} and enhancement of the H{sub 2} uptake of approximately 275% at 80 000 Pa at 77 K. This method resulted in frameworks with permanent lithium content after repeated solvent exchange as confirmed by inductively coupled plasma mass spectrometry. Lithium counterion replacement appears to increase porosity after activation through replacement of bulkier, softer counterions and demonstrates tuning of pore size and properties in MOFs.

  1. Lithium inclusion in indium metal-organic frameworks showing increased surface area and hydrogen adsorption

    Investigation of counterion exchange in two anionic In-Metal-Organic Frameworks (In-MOFs) showed that partial replacement of disordered ammonium cations was achieved through the pre-synthetic addition of LiOH to the reaction mixture. This resulted in a surface area increase of over 1600% in (Li [In(1,3 − BDC)2])n and enhancement of the H2 uptake of approximately 275% at 80 000 Pa at 77 K. This method resulted in frameworks with permanent lithium content after repeated solvent exchange as confirmed by inductively coupled plasma mass spectrometry. Lithium counterion replacement appears to increase porosity after activation through replacement of bulkier, softer counterions and demonstrates tuning of pore size and properties in MOFs

  2. Analysis and tests of TF magnet insulation samples for the JET upgrade to 4 tesla

    The JET Toroidal Field (TF) coils were originally designed for operation at 3.4 tesla. In order to upgrade the field to 4 tesla and thus improve the performance of the JET machine, new mechanical tests and analysis were carried out on the insulation of TF coil samples. They were aimed at investigating the mechanical properties and the status of the insulation in order to set allowable stresses and force limits. In particular since the shear stress in the insulation is strongly affected by the shear modulus of elasticity G, it is important to measure this parameter. A method for the measurement of G in glass-resin composites, the V-notched beam method (Iosipescu method), was applied. The particular shape of the rectangular Iosipescu V-notched sample and the particular modality of force application produce pure shear stress for a reliable measurement of the G value and of the shear strength of the insulation. The effect of temperature on these mechanical properties was also investigated. Results show higher average shear strength with lower scatter compared with previous tests on conventional rectangular samples, thus confirming the reliability of the method. Micrographic analysis of the insulation and comparison between the straight and curved regions of the magnet, where the highest stress occurs, confirm the good quality of the impregnation of the coil. Glass-resin content, void content, micros and TG measurements have been performed on different samples and correlation between the different properties of the insulation investigated. Moreover fatigue tests at different temperatures were performed and data analyzed with the cumulative damage technique, which allows for an extrapolation of the fatigue curve with less samples than the standard method. (author)

  3. Do dolphins rehearse show-stimuli when at rest? Delayed matching of auditory memory

    DorotheeKremers

    2011-12-01

    Full Text Available The mechanisms underlying vocal mimicry in animals remain an open question. Delphinidae are able to copy sounds from their environment that are not produced by conspecifics. Usually, these mimicries occur associated with the context in which they were learned. No reports address the question of separation between auditory memory formation and spontaneous vocal copying although the sensory and motor phases of vocal learning are separated in a variety of songbirds. Here we show that captive bottlenose dolphins produce, during their nighttime resting periods, non-dolphin sounds that they heard during performance shows. Generally, in the middle of the night, these animals produced vocal copies of whale sounds that had been broadcast during daily public shows. As their life history was fully known, we know that these captive dolphins had never had the opportunity to hear whale sounds before then. Moreover, recordings made before the whale sounds started being broadcast revealed that they had never emitted such sounds before. This is to our knowledge the first evidence for a separation between formation of auditory memories and the process of learning to produce calls that match these memories in a marine mammal. One hypothesis is that dolphins may rehearse some special events heard during the daytime and that they then express vocally what could be conceived as a more global memory. These results open the way for broader views on how animals might rehearse life events while resting or maybe dreaming.

  4. Ecological changes in Miocene mammalian record show impact of prolonged climatic forcing.

    Badgley, Catherine; Barry, John C; Morgan, Michèle E; Nelson, Sherry V; Behrensmeyer, Anna K; Cerling, Thure E; Pilbeam, David

    2008-08-26

    Geohistorical records reveal the long-term impacts of climate change on ecosystem structure. A 5-myr record of mammalian faunas from floodplain ecosystems of South Asia shows substantial change in species richness and ecological structure in relation to vegetation change as documented by stable isotopes of C and O from paleosols. Between 8.5 and 6.0 Ma, C(4) savannah replaced C(3) forest and woodland. Isotopic historical trends for 27 mammalian herbivore species, in combination with ecomorphological data from teeth, show three patterns of response. Most forest frugivores and browsers maintained their dietary habits and disappeared. Other herbivores altered their dietary habits to include increasing amounts of C(4) plants and persisted for >1 myr during the vegetation transition. The few lineages that persisted through the vegetation transition show isotopic enrichment of delta(13)C values over time. These results are evidence for long-term climatic forcing of vegetation structure and mammalian ecological diversity at the subcontinental scale. PMID:18711123

  5. Anthraquinones isolated from Cassia tora (Leguminosae) seed show an antifungal property against phytopathogenic fungi.

    Kim, Young-Mi; Lee, Chi-Hoon; Kim, Hyo-Gyung; Lee, Hoi-Seon

    2004-10-01

    The fungicidal activities of Cassia tora extracts and their active principles were determined against Botrytis cineria, Erysiphe graminis, Phytophthora infestans, Puccinia recondita, Pyricularia grisea, and Rhizoctonia solani using a whole plant method in vivo and were compared with synthetic fungicides and three commercially available anthraquinones. The responses varied with the plant pathogen tested. At 1 g/L, the chloroform fraction of C. tora showed a strong fungicidal activity against B. cinerea, E. graminis, P. infestans, and R. solani. Emodin, physcion, and rhein were isolated from the chloroform fraction using chromatographic techniques and showed strong and moderate fungicidal activities against B. cinerea, E. graminis, P. infestans, and R. solani. Furthermore, aloe-emodin showed strong and moderate fungicidal activities against B. cinerea and R. solani, respectively, but did not inhibit the growth of E. graminis, P. infestans, P. recondita, and Py. grisea. Little or no activity was observed for anthraquinone and anthraquinone-2-carboxylic acid when tested at 1 g/L. Chlorothalonil and dichlofluanid as synthetic fungicides were active against P. infestans and B. cinerea at 0.05 g/L, respectively. Our results demonstrate the fungicidal actions of emodin, physcion, and rhein from C. tora. PMID:15453672

  6. Live Reporting in a News / Current Affairs TV Show as a Factor of (Non Credibility

    Tena Perišin

    2010-12-01

    Full Text Available Only a perfunctory glance at the content of current aff airs/news programs makes it clear that in just a few years time, live reporting on Croatian TV news shows has increased dramatically. Technologicaladvancements, the equipping of TV stations with mobile satellite vans, and the pressure of competition have all resulted in increased instances of live reporting. When investigating news values, pictureand sound, as well as the possibility of immediate, timely reporting represent the key characteristics of TV journalism. In this context, live reports, as part of a news segment, should add to the authenticity and credibility of the program. Currently, however, TV broadcasting houses attempt to best one another in the number of live broadcasts as a means to purport a higher quality of their program. The direct address to the camera turns a reporter from an anonymous bearer of information into the “main star”. The figures accumulated on the extent of this form used in a news show do not determine the professional level of the editorial policy. Live reporting cannot be regarded as news value if other news values are neglected in the process. Recent research shows that live reports, in most cases, have been stripped of the initial notion of reporting on important and recent events. As such, they are becoming less of a justifi ed element in the creation of news.

  7. Annual results 2004

    This 2004 annual evaluation of the french RTE company (electric power transport network) provides information on the 2004 results on: institutional information, financial results, customers and market, industrial resources, environment and consultation, human resources and international aspects. (A.L.B.)

  8. Results from OPERA

    In this report, the details of new ντ event detected by OPERA were reported. Also first result on νμ to νe oscillation search in OPERA was described. The result excluded the high Δm2 region down to sin22θ13∼2×10−2

  9. Duration and Results (PECODR

    Martin Dawes

    2007-01-01

    Conclusions Results suggest a PECODR-related structure exists in medical abstracts and that there might be lexical patterns specific to these elements. More sophisticated computer-assisted lexical-semantic analysis might refine these results, and pave the way to automating PECODR indexing, and improve information retrieval in primary care.

  10. Recent results from TRISTAN

    Enomoto, Ryoji [National Laboratory for High Energy Physics, Ibaraki (Japan)

    1997-01-01

    TRISTAN results on {gamma}{gamma} physics from 1994 to 1995 are reviewed in this report. We have systematically investigated jet production, the {gamma}-structure function, and charm pair production in {gamma}{gamma} processes. The results are discussed, and future prospects are presented.

  11. Recent results from CDF

    A review of recent results from CDF is presented. The results are presently based on data samples of 19.3pb-1 at a center-of-mass energy of 1.8 TeV. This includes the top quark search, the measurements of the W mass and width, and new particle searches. (author)

  12. Latest Results from PHOBOS

    Hofman, D.J.; Collaboration, for the PHOBOS

    2007-01-01

    This manuscript contains a summary of the latest physics results from PHOBOS, as reported at Quark Matter 2006. Highlights include the first measurement from PHOBOS of dynamical elliptic flow fluctuations as well as an explanation of their possible origin, two-particle correlations, identified particle ratios, identified particle spectra and the latest results in global charged particle production.

  13. Latest results from PHOBOS

    This paper contains a summary of the latest physics results from PHOBOS, as reported at Quark Matter 2006. Highlights include the first measurement from PHOBOS of dynamical elliptic flow fluctuations as well as an explanation of their possible origin, two-particle correlations, identified particle ratios, identified particle spectra and the latest results in global charged particle production

  14. Radio Show on Books and Libraries as a Means of Promoting the Public Library: Marking the 200th Edition of the Show Tvoja,

    Peter Pavletič

    2014-04-01

    Full Text Available ABSTRACTSince 2004, the Ciril Kosmač Library of Tolmin has been continuously preparing a radio show on books and libraries on the local radio station Alpski val. The show has been used as an advertising platform or as a means of primary library promotion. The radio show is regarded as one of the tools of what is termed market communication, and it is intended to provide broad public information on the services of a public library, to promote the library’s activities and holdings and to foster a reading culture. The aim of the show is to stimulate the potential user interest in visiting and using the services of a public library, to expand the circle of users and consequently raise the number of visits and library loans. The title of the show, its audio image, target audience, metapromotion and substantive concept are all key to planning the radio show on books and libraries. The radio show is an example of an effective tool that helps to establish the library’s ties with the local community. This example of best practices shows that it is worth pursuing this activity in Slovenia’s public libraries and highlighting it on their websites.

  15. Le "Talk-Show" comme form de la communication de Masse (The Talk-Show as a Form of Mass Communication).

    Mininni, Guiseppe

    1990-01-01

    Discusses the dynamics of human interaction as manifested through the confines of the talk-show, and explores how the talk-show medium defines and manipulates the language "event" (communicative activity) through its own set of paralinguistic rules and theatrical techniques. (WS)

  16. Evaluation of pulmonary perfusion in lung regions showing isolated xenon-133 ventilation washout defects

    Xenon-133 washout phase imaging is often used to help determine whether the etiology of a perfusion defect is embolic or due to pulmonary parenchymal pathology, such as chronic obstructive pulmonary disease. This study was designed to evaluate the pulmonary blood flow patterns associated with isolated defects on xenon washout images. Scintigraphic lung studies were reviewed until 100 cases with abnormal ventilation results were obtained. Ventilation abnormalities were compared with the corresponding perfusion scan results at the same anatomic site. Of the 208 individual lung regions with xenon abnormalities, 111 showed isolated washout defects (that is, with normal washin). Ninety-four of these 111 sites showed either normal perfusion or a small, nonsegmental corresponding perfusion defect. Three segmental perfusion defects were noted in association with isolated xenon retention. In each of these cases, however, the patient was felt actually to have pulmonary embolism. Thus, it is recommended that, for interpretation of scintigraphic images in the assessment of pulmonary embolism, lung pathology associated with isolated xenon retention not be considered a potential cause for large or segmental perfusion defects

  17. Evidence of Microporous Carbon Nanosheets Showing Fast Kinetics in both Gas Phase and Liquid Phase Environments.

    Jin, Zhen-Yu; Xu, Yuan-Yuan; Sun, Qiang; Lu, An-Hui

    2015-10-01

    Despite the great advantages of microporous carbons for applications in gas phase separation, liquid phase enrichment, and energy storage devices, direct experiment data and theoretical calculations on the relevance of properties and structures are quite limited. Herein, two model carbon materials are designed and synthesized, i.e., microporous carbon nanosheets (MCN) and microporous carbon spheres (MCS). They both have nearly same composition, surface chemistry, and specific surface area, known morphology, but distinguishable diffusion paths. Based on these two types of materials, a reliable relationship between the morphology with different diffusion paths and adsorption kinetics in both gas phase and liquid phase environments is established. When used for CO2 capture, MCN shows a high saturated CO2 capacity of 8.52 ?mol m(-2) and 18.4 mmol cm(-3) at 273 K and ambient pressure, and its calculated first-order rate constant is ?7.4 times higher than that of MCS. Moreover, MCN shows a quick and high uptake of Cr (VI) and a higher-rate performance for supercapacitors than MCS does. These results strongly confirm that MCN exhibits improved kinetics in gas phase separation, liquid phase enrichment, and energy storage devices due to its shorter diffusion paths and larger exposed geometrical area resulting from the nanosheet structure. PMID:26192395

  18. Subterranean phylogeography of freshwater crayfishes shows extensive gene flow and surprisingly large population sizes.

    Buhay, Jennifer E; Crandall, Keith A

    2005-12-01

    Subterranean animals are currently viewed as highly imperiled, precariously avoiding extinction in an extreme environment of darkness. This assumption is based on a hypothesis that the reduction in visual systems and morphology common in cave faunas reflects a genetic inability to adapt and persist coupled with the perception of a habitat that is limited, disconnected, and fragile. Accordingly, 95% of cave fauna in the United States are presumed endangered due to surface environmental degradation and limited geographic distributions. Our study explores the subterranean phylogeography of stygobitic crayfishes in the southeastern United States, a global hotspot of groundwater biodiversity, using extensive geographic sampling and molecular data. Despite their endangered status, our results show that subterranean crayfish species have attained moderate to high levels of genetic diversity over their evolutionary histories with large population sizes and extensive gene flow among karst systems. We then compare the subterranean population histories to those of common surface stream-dwelling crayfishes. Our results show recent drastic declines in genetic variability in the surface crayfish and suggest that these species also warrant conservation attention. PMID:16313591

  19. A physical map of Brassica oleracea shows complexity of chromosomal changes following recursive paleopolyploidizations

    Giattina Emily

    2011-09-01

    Full Text Available Abstract Background Evolution of the Brassica species has been recursively affected by polyploidy events, and comparison to their relative, Arabidopsis thaliana, provides means to explore their genomic complexity. Results A genome-wide physical map of a rapid-cycling strain of B. oleracea was constructed by integrating high-information-content fingerprinting (HICF of Bacterial Artificial Chromosome (BAC clones with hybridization to sequence-tagged probes. Using 2907 contigs of two or more BACs, we performed several lines of comparative genomic analysis. Interspecific DNA synteny is much better preserved in euchromatin than heterochromatin, showing the qualitative difference in evolution of these respective genomic domains. About 67% of contigs can be aligned to the Arabidopsis genome, with 96.5% corresponding to euchromatic regions, and 3.5% (shown to contain repetitive sequences to pericentromeric regions. Overgo probe hybridization data showed that contigs aligned to Arabidopsis euchromatin contain ~80% of low-copy-number genes, while genes with high copy number are much more frequently associated with pericentromeric regions. We identified 39 interchromosomal breakpoints during the diversification of B. oleracea and Arabidopsis thaliana, a relatively high level of genomic change since their divergence. Comparison of the B. oleracea physical map with Arabidopsis and other available eudicot genomes showed appreciable 'shadowing' produced by more ancient polyploidies, resulting in a web of relatedness among contigs which increased genomic complexity. Conclusions A high-resolution genetically-anchored physical map sheds light on Brassica genome organization and advances positional cloning of specific genes, and may help to validate genome sequence assembly and alignment to chromosomes. All the physical mapping data is freely shared at a WebFPC site (http://lulu.pgml.uga.edu/fpc/WebAGCoL/brassica/WebFPC/; Temporarily password-protected: account: pgml; password: 123qwe123.

  20. Task control signals in pediatric Tourette syndrome show evidence of immature and anomalous functional activity

    Francis M Miezin

    2009-11-01

    Full Text Available Tourette Syndrome (TS is a pediatric movement disorder that may affect control signaling in the brain. Previous work has proposed a dual-networks architecture of control processing involving a task-maintenance network and an adaptive control network (Dosenbach et al., 2008. A prior resting-state functional connectivity MRI (rs-fcMRI analysis in TS has revealed functional immaturity in both putative control networks, with “anomalous” correlations (i.e. correlations outside the typical developmental range limited to the adaptive control network (Church et al., 2009. The present study used functional MRI (fMRI to study brain activity related to adaptive control (by studying start-cues signals, and to task-maintenance (by studying signals sustained across a task set. Two hypotheses from the previous rs-fcMRI results were tested. First, adaptive control (i.e., start-cue activity will be altered in TS, including activity inconsistent with typical development (“anomalous”. Second, group differences found in task maintenance (i.e., sustained activity will be consistent with functional immaturity in TS. We examined regions found through a direct comparison of adolescents with and without TS, as well as regions derived from a previous investigation that showed differences between unaffected children and adults. The TS group showed decreased start-cue signal magnitude in regions where start-cue activity is unchanged over typical development, consistent with anomalous adaptive control. The TS group also had higher magnitude sustained signals in frontal cortex regions that overlapped with regions showing differences over typical development, consistent with immature task maintenance in TS. The results demonstrate task-related fMRI signal differences anticipated by the atypical functional connectivity found previously in adolescents with TS, strengthening the evidence for functional immaturity and anomalous signaling in control networks in adolescents with TS.

  1. Adenoma and carcinoma components in colonic tumors show discordance for KRAS mutation.

    Hershkovitz, Dov; Simon, Einav; Bick, Tova; Prinz, Elad; Noy, Shawna; Sabo, Edmond; Ben-Izhak, Ofer; Vieth, Michael

    2014-09-01

    Activating mutations in KRAS are common events in the pathogenesis of colorectal carcinoma and predict response to treatment with anti-EGFR antibodies. Molecular pathology testing for KRAS mutations has become the standard of practice for patients with metastatic colorectal carcinoma. Despite the known histologic and molecular differences between adenomas and carcinomas, the concordance of KRAS mutation between adenomas and carcinomas has not been established leaving some open questions regarding the appropriate choice of tissue for KRAS mutation analysis and correct interpretation of the test results. To address these questions, we analyzed the concordance of KRAS mutation in 70 tumors that contained both adenoma and carcinoma components (2 cases of intramucosal carcinoma, 66 cases with invasion of the submucosa, and 2 invading the muscularis propria). For each case, DNA was separately isolated from the adenoma and the carcinoma component and analyzed for KRAS mutation using direct sequencing. Overall, 30 (43%) of the adenoma cases and 36 (51%) of the carcinoma cases were positive for KRAS mutation. Of the 70 cases, 16 (23%) showed discordant results. Interestingly, the fraction of discordant cases went down as the depth of carcinoma invasion increased. In summary, we identified significant KRAS mutation discordance between the adenoma and carcinoma component of the lesion. Our results suggest that effort should be made to analyze only the invasive component of the lesion and that caution should be taken when interpreting a result based on DNA extracted from noninvasive elements. PMID:24998492

  2. LINE-1 methylation shows little intra-patient heterogeneity in primary and synchronous metastatic colorectal cancer

    Long interspersed nucleotide element 1 (LINE-1) hypomethylation is suggested to play a role in the progression of colorectal cancer (CRC). To assess intra-patient heterogeneity of LINE-1 methylation in CRC and to understand its biological relevance in invasion and metastasis, we evaluated the LINE-1 methylation at multiple tumor sites. In addition, the influence of stromal cell content on the measurement of LINE-1 methylation in tumor tissue was analyzed. Formalin-fixed paraffin-embedded primary tumor tissue was obtained from 48 CRC patients. Matched adjacent normal colon tissue, lymph node metastases and distant metastases were obtained from 12, 18 and 7 of these patients, respectively. Three different areas were microdissected from each primary tumor and included the tumor center and invasive front. Normal mucosal and stromal cells were also microdissected for comparison with the tumor cells. The microdissected samples were compared in LINE-1 methylation level measured by multicolor MethyLight assay. The assay results were also compared between microdissected and macrodissected tissue samples. LINE-1 methylation within primary tumors showed no significant intra-tumoral heterogeneity, with the tumor center and invasive front showing identical methylation levels. Moreover, no difference in LINE-1 methylation was observed between the primary tumor and lymph node and distant metastases from the same patient. Tumor cells showed significantly less LINE-1 methylation compared to adjacent stromal and normal mucosal epithelial cells. Consequently, LINE-1 methylation was significantly lower in microdissected samples compared to macrodissected samples. A trend for less LINE-1 methylation was also observed in more advanced stages of CRC. LINE-1 methylation shows little intra-patient tumor heterogeneity, indicating the suitability of its use for molecular diagnosis in CRC. The methylation is relatively stable during CRC progression, leading us to propose a new concept for the association between LINE-1 methylation and disease stage

  3. Environmental drivers of phototrophic biofilms in an Alpine show cave (SW-Italian Alps)

    The proliferation of lampenflora is a major threat for the conservation of show caves, since phototrophic organisms cause physical, chemical and aesthetic damage to speleothems. In this paper we examine the environmental factors influencing the presence and the growth of the three main photosynthetic groups composing phototrophic biofilms in the Bossea show cave (SW-Italian Alps). The presence and the primary production of cyanobacteria, diatoms and green algae were detected with BenthoTorch®, an instrument for in situ measurement of chlorophyll a concentration that has never been used before in caves. By means of different techniques of regression analysis, we highlighted the response of the three photosynthetic groups to different environmental factors. Illuminance proved to be the main factor influencing positively both the probability of the presence and the productivity of the three groups. The presence of seeping water on the substrate and the distance from the cave entrance proved to play an important role in determining patterns of colonization. By means of GIS techniques, we provide thematic maps of the cave, providing a representation of pattern of the density of the three examined photosynthetic groups within different areas of the cave. The same approach may apply to other show caves, aiming at providing suggestions for the cave management (i.e. cleaning of the cave walls and positioning of artificial lights) and reduce impact caused by tourism. - Highlights: • We used a PAM fluorimeter on autotrophic biofilms in a show cave for the first time. • We modelled the environmental factors influencing phototrophic biofilms. • Illuminance, moisture and distance from the entrance proved to be significant. • We produced thematic maps illustrating our results. • We provide suggestions for cave management

  4. Environmental drivers of phototrophic biofilms in an Alpine show cave (SW-Italian Alps)

    Piano, E., E-mail: elena.piano@unito.it [Department of Life Sciences and Systems Biology, University of Turin, Via Accademia Albertina 13, 10123 Turin (Italy); Bona, F.; Falasco, E. [Department of Life Sciences and Systems Biology, University of Turin, Via Accademia Albertina 13, 10123 Turin (Italy); La Morgia, V. [ISPRA, via Ca' Fornacetta, 9, 40064 Ozzano dell' Emilia (Italy); Badino, G. [Department of Physics, University of Turin, Via P. Giuria 1, 10125 Turin (Italy); Isaia, M. [Department of Life Sciences and Systems Biology, University of Turin, Via Accademia Albertina 13, 10123 Turin (Italy)

    2015-12-01

    The proliferation of lampenflora is a major threat for the conservation of show caves, since phototrophic organisms cause physical, chemical and aesthetic damage to speleothems. In this paper we examine the environmental factors influencing the presence and the growth of the three main photosynthetic groups composing phototrophic biofilms in the Bossea show cave (SW-Italian Alps). The presence and the primary production of cyanobacteria, diatoms and green algae were detected with BenthoTorch®, an instrument for in situ measurement of chlorophyll a concentration that has never been used before in caves. By means of different techniques of regression analysis, we highlighted the response of the three photosynthetic groups to different environmental factors. Illuminance proved to be the main factor influencing positively both the probability of the presence and the productivity of the three groups. The presence of seeping water on the substrate and the distance from the cave entrance proved to play an important role in determining patterns of colonization. By means of GIS techniques, we provide thematic maps of the cave, providing a representation of pattern of the density of the three examined photosynthetic groups within different areas of the cave. The same approach may apply to other show caves, aiming at providing suggestions for the cave management (i.e. cleaning of the cave walls and positioning of artificial lights) and reduce impact caused by tourism. - Highlights: • We used a PAM fluorimeter on autotrophic biofilms in a show cave for the first time. • We modelled the environmental factors influencing phototrophic biofilms. • Illuminance, moisture and distance from the entrance proved to be significant. • We produced thematic maps illustrating our results. • We provide suggestions for cave management.

  5. Enova results report 2005

    In 2005 Enova entered into agreements with 186 projects that together provided an energy result of 2 TWh. The result is almost evenly divided between projects providing higher energy production and projects that reduce energy use. The energy production consists of 585 GWh in new wind power and 409 GWh in new heat energy in 2005. Overall for the period 2001 to 2005, Enova contracted for energy results of well over 6.6 TWh. Enova is doing well in relation to the objectives set for its activities

  6. Recent results from PETRA

    Recent results on the search for new particles, new thresholds and on properties of B-mesons are reported. No new particle has been observed. More stringent limits on production cross sections have been obtained. (orig.)

  7. Vegetation Transect Results, 1975

    US Fish and Wildlife Service, Department of the Interior — This report summarizes the results of vegetation transects conducted in millet ponds A, B, and C; goose pasture; supply pond; and fields 4A, 4B, 21, and 22 of...

  8. Haiti DevResults

    US Agency for International Development — DevResults is a web-based portfolio management system that tracks program data for the Haiti Mission that was awarded in April of 2013. (The Mozambique and/or...

  9. Atmospheric Deposition Modeling Results

    U.S. Environmental Protection Agency This asset provides data on model results for dry and total deposition of sulfur, nitrogen and base cation species. Components include deposition velocities, dry...

  10. Ibis DDT test results

    US Fish and Wildlife Service, Department of the Interior This document contains test results from a study done to determine the organochlorine levels in the livers of whitefaced ibis from Stillwater Wildlife Management...

  11. Results obtained at Saturne

    The proton scattering results obtained in the synchrotron Saturne are summarized: target, reaction, energy of the incident proton, nature of the levels studied, limits of the transfer momentum range measured, and corresponding elastic scattering cross-sections

  12. ATLAS PDF results

    Stockton, Mark; The ATLAS collaboration

    2015-01-01

    Results are presented on recent ATLAS measurements which are sensitive to parton distribution functions. This covers a wide range of cross section measurements, including those from: jets, photons, W+Z bosons and top quarks.

  13. Transacsys PLC - Final Results

    2002-01-01

    Final results from Transacsys PLC. A subsidary of this company was set up to develop the CERN EDH system into a commercial product but incurred too much financial loss so the project was cancelled (1/2 page).

  14. Recent Results from STAR

    Oldenburg, M.; collaboration, for the STAR

    2002-01-01

    Besides an introduction to the Relativistic Heavy-Ion Collider (RHIC) and the experimental setup of STAR recent results are discussed. These include anisotropic flow, jets in nucleus-nucleus collisions and ultra-peripheral heavy-ion collisions.

  15. Microenterprise Results Reporting

    US Agency for International Development — Microenterprise Results Reporting (MRR) is an annual report to the U.S. Congress providing funding and program data on USAID's microenterprise activities. The MRR...

  16. WNV Mosquito Test Results

    U.S. Department of Health & Human Services — List of locations and test results for pools of mosquitoes tested through the Chicago Department of Public Health Environmental Health program. The Chicago...

  17. Vegetation Transect Results, 1976

    US Fish and Wildlife Service, Department of the Interior — This report summarizes the results of 11 vegetative transects conducted in July and August, 1976 at Clarence Cannon NWR. The tracts completed included millet ponds...

  18. Recent Results from PHOBOS

    Loizides, Constantin

    2007-01-01

    In this manuscript we give a short summary of recent physics results from PHOBOS. Particular emphasis is put on elliptic flow, fluctuations in the initial geometry and the recent measurements of elliptic flow fluctuations.

  19. Compilation of results 1987

    A compilation is carried out which in concentrated form presents reports on research and development within the nuclear energy field covering a two and a half years period. The foregoing report was edited in December 1984. The projects are presendted with title, project number, responsible unit, person to contact and short result reports. The result reports consist of short summaries over each project. (L.F.)

  20. Higgs results from ATLAS

    Chen, Xin; The ATLAS collaboration

    2015-01-01

    The updated Higgs measurements in various search channels with ATLAS Run 1 data are reviewed. Both the Standard Model (SM) Higgs results, such as $H\\to\\gamma\\gamma,ZZ,WW,\\tau\\tau,\\mu\\mu,b\\bar{b}$, and Beyond Standard Model (BSM) results, such as the charged Higgs, Higgs invisible decay and tensor couplings, are summarized. Prospects for future Higgs searches are briefly discussed.

  1. Unfavorable results in replantation

    Abraham G Thomas

    2013-01-01

    Full Text Available Reattachment of amputated parts of the body (Replantation has become a reality since the first arm replant was carried out six decades ago. Failures were not uncommon in the beginning, leading on to the analysis of the problem and refinements in technique. Improvements in sutures, instrumentation and better microscopes further helped the surgeons to do replantation with better finesse and functional results. Evaluation of results and particularly failure and long term results help the younger surgeons to learn from the difficulties faced earlier to do better in the future. An attempt is made to list various aspects of replantation experienced by the author during the past 30 years, particularly in reference to unfavorable results, which had been occasionally total failure, or a partial failure, with poor function and cosmesis due to infection. An insensate limb with poor function is the result of inadequate or improper nerve coaptation or infection destroying the whole repair. It is apt to mention that infection is mostly the result of poor vascularity due to devitalized tissue. Difficulties arise often in identifying the viable tissue, particularly while debriding in the distal amputated part since there is no bleeding. Experience counts in this, specifically to identify the viable muscle. The factors that may lead to complications are listed with remarks to avoid them.

  2. El SHOW DE JORGE BARN como paradigma de neopopulismo cultural en la televisin Colombiana JORGE BARON'S show as paradigm of cultural neo-populism in the colombian television

    Isabel Noem Rodrguez

    2010-12-01

    Full Text Available Este artculo parte de la investigacin de campo sobre El Show de las Estrellas, el programa musical ms antiguo y popular de la televisin colombiana. El anlisis de caso es un pretexto para replantear la discusin sobre polticas culturales en el contexto -aparentemente paradjico- de violencia estructural, privatizacin y auge del populismo de derecha que caracteriza la poltica en Colombia en los ltimos aos.This article comes from the investigation field of the Stars Show (El Show de las Estrellas, the oldest and most popular musical TV show in Colombian television. The case analysis is an excuse to reframe the discussion on cultural policies in the context, apparently paradoxical, of structural violence, privatization and peak of the right populism that characterizes the Colombian politics in the last years.

  3. Results from JADE

    Topological distributions of multihadron events from e+e- annihilation are studied at ?s of about 30 GeV. An excess of planar events is observed, which cannot be explained by statistical fluctuations in the standard two-jet model. We show that the planar events possess three-jet structure and that the broader jet consists of two-colinear jets in its own rest system. This strongly suggests gluon bremsstrahlung as the origin of the planar three-jet events. Different particle densities among the jets give first indications of different behaviour of quark jets and gluon jets. (orig.)

  4. Review of theoretical results

    Nowadays the 'experimental' charge densities are produced with convincing error estimates due to new methods and techniques. In addition the accuracy of those experiments means that r.m.s. radii are known within a few hundredths of a fermi. Because of that accuracy the theorists are left far behind. In order to show which theoretical possiblities exist at the moment we will discuss the single particle shell model and the Hartree-Fock or mean field approximation. Corrections to the mean field approximation are described. Finally, some examples and conclusions are presented. (KBE)

  5. Rhabdomyosarcoma cells show an energy producing anabolic metabolic phenotype compared with primary myocytes

    Higashi Richard M

    2008-10-01

    Full Text Available Abstract Background The functional status of a cell is expressed in its metabolic activity. We have applied stable isotope tracing methods to determine the differences in metabolic pathways in proliferating Rhabdomysarcoma cells (Rh30 and human primary myocytes in culture. Uniformly 13C-labeled glucose was used as a source molecule to follow the incorporation of 13C into more than 40 marker metabolites using NMR and GC-MS. These include metabolites that report on the activity of glycolysis, Krebs' cycle, pentose phosphate pathway and pyrimidine biosynthesis. Results The Rh30 cells proliferated faster than the myocytes. Major differences in flux through glycolysis were evident from incorporation of label into secreted lactate, which accounts for a substantial fraction of the glucose carbon utilized by the cells. Krebs' cycle activity as determined by 13C isotopomer distributions in glutamate, aspartate, malate and pyrimidine rings was considerably higher in the cancer cells than in the primary myocytes. Large differences were also evident in de novo biosynthesis of riboses in the free nucleotide pools, as well as entry of glucose carbon into the pyrimidine rings in the free nucleotide pool. Specific labeling patterns in these metabolites show the increased importance of anaplerotic reactions in the cancer cells to maintain the high demand for anabolic and energy metabolism compared with the slower growing primary myocytes. Serum-stimulated Rh30 cells showed higher degrees of labeling than serum starved cells, but they retained their characteristic anabolic metabolism profile. The myocytes showed evidence of de novo synthesis of glycogen, which was absent in the Rh30 cells. Conclusion The specific 13C isotopomer patterns showed that the major difference between the transformed and the primary cells is the shift from energy and maintenance metabolism in the myocytes toward increased energy and anabolic metabolism for proliferation in the Rh30 cells. The data further show that the mitochondria remain functional in Krebs' cycle activity and respiratory electron transfer that enables continued accelerated glycolysis. This may be a common adaptive strategy in cancer cells.

  6. Total 2003 Results

    This document presents the 2003 results of Total Group: consolidated account, special items, number of shares, market environment, 4. quarter 2003 results, full year 2003 results, upstream (key figures, proved reserves), downstream key figures, chemicals key figures, parent company accounts and proposed dividends, 2004 sensitivities, summary and outlook, operating information by segment for the 4. quarter and full year 2003: upstream (combined liquids and gas production by region, liquids production by region, gas production by region), downstream (refinery throughput by region, refined product sales by region, chemicals), impact of allocating contribution of Cepsa to net operating income by business segment: equity in income (loss) and affiliates and other items, Total financial statements: consolidated statement of income, consolidated balance sheet (assets, liabilities and shareholder's equity), consolidated statements of cash flows, business segments information. (J.S.)

  7. Further results on concordance relations

    Bouyssou, Denis; Pirlot, Marc

    2005-01-01

    The purpose of this note is to sharpen the results in Bouyssou and Pirlot (2005) giving an axiomatic characterization of concordance relations. We show how the conditions used in that paper can be weakened so as to become independent from the conditions needed to characterize a general conjoint measurement model tolerating intransitive and/or incomplete relations. This leads to a clearer characterization of concordance relations within this general model.

  8. HIGGS RESULTS FROM ATLAS

    Benhar Noccioli, Eleonora; The ATLAS collaboration

    2016-01-01

    This document presents the most recent ATLAS results on the searches for additional heavy scalars, which could confirm the existence of an extended Higgs sector. The new results include searches for charged as well as for neutral heavy Higgs bosons, decaying to a variety of final states. All analyses are performed using the 2015 LHC pp collision data at 13 TeV centre-of-mass energy, corresponding to an integrated luminosity of 3.2 fb−1 recorded with the ATLAS detector.

  9. Results from Adone

    Celio, R B

    1979-01-01

    A short review on recent experimental results obtained at Adone, on multihadronic e/sup +/e/sup -/ annihilation is given. Results and comments concern: R values, compared with QCD and EVMD predictions, charged and neutral multiplicities, threshold for 'energy crisis', G parities and SU/sub 3/ checks, sigma (2 pi /sup +/2 pi /sup -/); evidence for a large rho "(1600), sigma ( pi /sup +/ pi /sup -/2 pi degrees ); non evidence for a rho '(1250), and sigma (2 pi /sup +/2 pi /sup -/2 pi degrees ); evidence and interpretation of 1820. (8 refs).

  10. Recent results from AMY

    Results from the AMY experiment at the TRISTAN e+e- collider are presented using a data sample of about 28 pb-1 at center of mass energies between 50 and 60.8 GeV. The measured value of R, which is about 2? higher than the standard model expectation for c.m. energy above 56 GeV, is presented and several possible explanations are discussed. The results of the forward-backward asymmetry measurement of e+e- ? bb-bar events, tests of QCD in the hadronic jets, and the search of heavy leptons are also presented. (author)

  11. Results from SAGE II

    The Russian-American Gallium solar neutrino Experiment (SAGE) began the second phase of operation (SAGE II) in September of 1992. Monthly measurements of the integral flux of solar neutrinos have been made with 55 tonnes of gallium. The K-peak results of the first nine runs of SAGE II give a capture rate of 66-13+18 (stat) -7+5 (sys) SNU. Combined with the SAGE I result of 73-16+18 (stat) -75 (sys) SNU, the capture rate is 69-11+11 (stat) -7+5 (sys) SNU. This represents only 52%--56% of the capture rate predicted by different Standard Solar Models

  12. Geochemical investigations and results

    The following information can be derived from results so far for a final store: - With known mineralogy, precise information can be given on the solution metamorphosis processes to be expected. The previous results of this in-situ experiment have confirmed the theoretical considerations. - Sensors were developed and tested, which make possible continuous monitoring under hydrostatic pressure in a final store in the case of incoming solution, i.e. for exploration bores. - The collection of physical and chemical parameters in open sections and shafts creates the basis for assessing the effect of backfilling from the chemical point of view. (orig./PW)

  13. RTE - 2012 financial results

    The mission of RTE, the French electricity Transportation grid, a public service assignment, is to balance the electricity supply and demand in real time. This report presents RTE's financial results for 2012: increase of investments for services to clients, performance results, financial balance, stability of the economical model. RTE's regulated economical model, main financial indicators, 2007-2012 investments, 2012 investments by category, 2012 turnover, 2012 costs structure, taxes, financial balance sheet at the end of 2012, and the share of electricity transport in the electricity price are presented in appendixes

  14. New Results from Chandra

    Forman, W; Jones, C; Vikhlinin, A A; Churazov, E

    2001-01-01

    We discuss two themes from Chandra observations of galaxies and clusters. First, we describe the effects of radio-emitting plasmas or ``bubbles'', inflated by active galactic nuclei, on the hot X-ray emitting gaseous atmospheres in galaxies and clusters. We describe the interaction of the ``bubbles'' and the X-ray emitting gas as the buoyant bubbles rise through the hot gas. Second, we describe sharp, edge-like surface brightness structures in clusters. Chandra observations show that these features are not shock fronts as was originally thought, but ``cold fronts'', most likely the boundaries of the remaining cores of merger components. Finally, we present recent observations of M86 and NGC507 which show similar sharp features around galaxies. For M86, the sharp edge is the boundary between the galaxy's X-ray corona and the Virgo cluster gas. The structures around NGC507, the central galaxy in a group, could be relics of galaxy formation or may reflect the motion of NGC507 in the larger potential of the group...

  15. Chapter 5: Monitoring results

    Poel, Bart; Thomsen, Kirsten Engelund; Schultz, Jørgen Munthe

    The monitoring results from the IEA Task 13 project "Advanced solar low energy houses" are described in this chapter. The underlying information was collected in the form of questionnaires. The questionnaires were formulated in such a way that participants are provided with a uniform lay-out to f...

  16. Economic results of terrorism

    Kadantu, Stanley

    2010-01-01

    This bachelor work focuses on the economic impacts of terrorist attacks in different countries. It draws our attention to the history and the present situation of terrorism. The main part deals with economic results of terrorism (labour, goods and services and infrastructure).

  17. Roadmap of Infinite Results

    Srba, Ji?

    2002-01-01

    This paper provides a comprehensive summary of equivalence checking results for infinite-state systems. References to the relevant papers will be updated continuously according to the development in the area. The most recent version of this document is available from the web-page http://www.brics.dk/~srba/roadmap....

  18. Higgs results from ATLAS

    Chen, Xin; The ATLAS collaboration

    2015-01-01

    The updated Higgs measurements in different search channels with Run 1 data is reviewed. Results for Beyound Standard Model Higgs searches such as the charged Higgs, the invisible decay and the tensor coupling are also given. Finally, prospects for Run2/3 Higgs search are briefly shown.

  19. Recent results from ATHENA

    The ATHENA experiment at CERN was dedicated to the production of cold antihydrogen atoms by mixing of antiprotons and a positron plasma. The first production took place in 2002. Results of studies of the production mechanisms of antihydrogen will be described. (author)

  20. ATLAS PDF Results

    Stockton, Mark; The ATLAS collaboration

    2015-01-01

    Uncertainties from parton distribution functions can limit our measurements of new cross sections and searches beyond the SM. Results are presented on recent ATLAS measurements which are sensitive to parton distribution functions. These cover a wide range of cross section measurements, including those from: jets, photons, $W$/$Z$ bosons and top quarks.

  1. Recent MILC spectrum results

    Bernard, C.; Blum, T; DeGrand, T. A.; DeTar, C.; Gottlieb, Steve; Heller, Urs M.; Hetrick, J.; McNeile, C.; Rummukainen, K.; Sugar, R. L.; Toussaint, Doug; Wingate, M.

    1996-01-01

    We report on results from three spectrum calculations with staggered quarks: 1) a quenched calculation with the standard action for the gluons and quarks; 2) a quenched calculation with improved actions for both the gluons and quarks; and 3) a calculation with two flavors of dynamical quarks using the standard actions for the gluons and quarks.

  2. Andrzej Lasota's selected results

    Józef Myjak

    2008-01-01

    In this article we recall Andrzej Lasota's selected results which either indicated new directions of research, or layed the foundations for new approaches, or solved interesting problems. The area of mathematical interests of Professor Andrzej Lasota was very large: ordinary differential equations, partial differential equations, dynamical systems, multifunctions, differential inclusions, functional differential equations, equations with retarded arguments, ergodic theory, invariant measures,...

  3. Recent results from PETRA

    The author gives a review about the experiments at PETRA. After a short description of the PETRA storage ring experimental results are presented which concern tests of QED, hadron production in e+e- annihilation, the search for evidence for gluons and new flavors, the search for fractionally charged or heavy stable particles, and two photon interactions. (HSI) 891 HSI/HSI 892 MKO

  4. Gems first science results

    Neichel, Benoit; Vidal, Fabrice; Rigaut, Francois; Carrasco, Eleazar Rodrigo; Arriagada, Gustavo; Serio, Andrew; Pessev, Peter; Winge, Claudia; van Dam, Marcos; Garrel, Vincent; Araujo, Constanza; Boccas, Maxime; Fesquet, Vincent; Galvez, Ramon; Gausachs, Gaston

    2014-01-01

    After 101 nights of commissioning, the Gemini MCAO system (GeMS) started science operations in December 2012. After a brief reminder on GeMS specificities, we describe the overall GeMS performance, and we focus then on the first science results obtained with GeMS, illustrating the unique capabilities of this new Gemini instrument.

  5. Higgs Search Results

    Raspereza, Alexei

    2002-01-01

    This paper shortly reports on the results of Higgs boson searches performed at LEP and Tevatron. No signal is found and limits on the mass and couplings of the Higgs boson are derived. Interpreting the data in the framework of the Standard Model, the 95% C.L. lower limit of 114.4 GeV on the Higgs boson mass is obtained.

  6. Results of CPLEAR

    The CPLEAR experiment uses tagged K0 and K0 produced in pp annihilation at rest to measure CP-, T- and CPT-violation parameters in the neutral kaon system. The results of these measurements and some implications are reported. (orig.)

  7. Test Results Prague

    Jakobi, J; Morlang, F.; Gilbert, A.; Firing, E.; Biella, M.; Helms, M.; Loth, S

    2006-01-01

    The document is the test report of the Prague test campaign that were conducted in the Integrated Project EMMA, a project of the sixth framework programme of the European Commission. It contains all results and conclusion that were gained with real time simulations and technical and operational trials at Prague Airport.

  8. NIH Research to Results

    ... Home Current Issue Past Issues Cover Story: Traumatic Brain Injury NIH Research to Results Past Issues / Fall 2008 Table of ... of stem cells to repair or replace damaged brain tissue is also a new avenue of research. Another important area of research involves the development ...

  9. Recent CDF results

    Gomez, Gervasio; /Cantabria Inst. of Phys.

    2007-11-01

    As of November of 2007, the CDF detector has recorded approximately 2.7 fb{sup -1} of data. This contribution describes some of the most recent and most relevant results from the CDF collaboration in all areas of its wide physics program, as well as some insights into the Tevatron reach for Higgs searches within the next few years.

  10. RTE annual results 2005

    This annual report presents the results of the RTE (Electric power Transport Network). The year 2005 is marked by the new status of RTE, as a limited company. The financial good performances, the market, the open network, the environmental policy, the human resources and the european and international relations are discussed. (A.L.B.)

  11. Recent results from HERA

    Here we present some of the recent results obtained by the ZEUS and H1 experiments at electron proton collider HERA. The main focus in this report is the properties of the proton and photon that are newly revealed at HERA, respectively through DIS and photoproduction processes. (author)

  12. Recent results from PHOBOS

    The PHOBOS Collaboration has measured charged particles emitted over the range -5.4 NN 19.6, 62.4, 130 and 200 GeV. In this contribution I will present recent results on the pseudorapidity distributions, total charged-particle production, and collective flow of particles obtained from these measurements. (author)

  13. Results of CPLEAR

    Rickenbach, R. [Basel Univ. (Switzerland); Adler, R. [Basel Univ. (Switzerland); Alhalel, T.; Angelopoulos, A.; Apostolakis, A.; Aslanides, E.; Backenstoss, G.; Bargassa, P.; Bee, C.P.; Behnke, O.; Benelli, A.; Bertin, V.; Blanc, F.; Bloch, P.; Carlson, P.; Carroll, M.; Carvalho, J.; Cawley, E.; Charalambous, S.; Chardin, G.; Chertok, M.B.; Cody, A.; Danielsson, M.; Dejardin, M.; Derre, J.; Ealet, A.; Eckart, B.; Eleftheriadis, C.; Evangelou, I.; Faravel, L.; Fassnacht, P.; Felder, C.; Ferreira-Marques, R.; Fetscher, W.; Fidecaro, M.; Filipcic, A.; Francis, D.; Fry, J.; Gabathuler, E.; Gamet, R.; Garreta, D.; Gerber, H.-J.; Go, A.; Guyot, C.; Haselden, A.; Hayman, P.J.; Henry-Couannier, F.; Hollander, R.W.; Hubert, E.; Jon-And, K.; Kettle, P.-R.; Kochowski, C.; Kokkas, P.; Kreuger, R.; Le Gac, R.; Leimgruber, F.; Liolios, A.; Machado, E.; Mandic, I.; Manthos, N.; Marel, G.; Mikuz, M.; Miller, J.; Montanet, F.; Nakada, T.; Pagels, B.; Papadopoulos, I.; Pavlopoulos, P.; Pinto da Cunha, J.; Policarpo, A.; Polivka, G.; Roberts, B.L.; Ruf, T.; Sakeliou, L.; Sanders, P.; Santoni, C.; Schaefer, M.; Schaller, L.A.; Schietinger, T.; Schopper, A.; Schune, P.; Soares, A.; Tauscher, L.; Thibault, C.; Touchard, F.; Touramanis, C.; Triantis, F.; Van Beveren, E.; Van Eijk, C.W.E.; Vlachos, S.; Weber, P.; Wigger, O.; Wolter, M.; Yeche, C.; Zavrtanik, D.; Zimmerman, D.; CPLEAR Collaboration

    1997-06-01

    The CPLEAR experiment uses tagged K{sup 0} and K{sup 0} produced in pp annihilation at rest to measure CP-, T- and CPT-violation parameters in the neutral kaon system. The results of these measurements and some implications are reported. (orig.).

  14. Hanseniaspora uvarum from Winemaking Environments Show Spatial and Temporal Genetic Clustering.

    Albertin, Warren; Setati, Mathabatha E; Miot-Sertier, Cécile; Mostert, Talitha T; Colonna-Ceccaldi, Benoit; Coulon, Joana; Girard, Patrick; Moine, Virginie; Pillet, Myriam; Salin, Franck; Bely, Marina; Divol, Benoit; Masneuf-Pomarede, Isabelle

    2015-01-01

    Hanseniaspora uvarum is one of the most abundant yeast species found on grapes and in grape must, at least before the onset of alcoholic fermentation (AF) which is usually performed by Saccharomyces species. The aim of this study was to characterize the genetic and phenotypic variability within the H. uvarum species. One hundred and fifteen strains isolated from winemaking environments in different geographical origins were analyzed using 11 microsatellite markers and a subset of 47 strains were analyzed by AFLP. H. uvarum isolates clustered mainly on the basis of their geographical localization as revealed by microsatellites. In addition, a strong clustering based on year of isolation was evidenced, indicating that the genetic diversity of H. uvarum isolates was related to both spatial and temporal variations. Conversely, clustering analysis based on AFLP data provided a different picture with groups showing no particular characteristics, but provided higher strain discrimination. This result indicated that AFLP approaches are inadequate to establish the genetic relationship between individuals, but allowed good strain discrimination. At the phenotypic level, several extracellular enzymatic activities of enological relevance (pectinase, chitinase, protease, β-glucosidase) were measured but showed low diversity. The impact of environmental factors of enological interest (temperature, anaerobia, and copper addition) on growth was also assessed and showed poor variation. Altogether, this work provided both new analytical tool (microsatellites) and new insights into the genetic and phenotypic diversity of H. uvarum, a yeast species that has previously been identified as a potential candidate for co-inoculation in grape must, but whose intraspecific variability had never been fully assessed. PMID:26834719

  15. Mycological study for a management plan of a neotropical show cave (Brazil

    Erika Linzi Silva Taylor

    2013-09-01

    Full Text Available Caves are stable environments with characteristics favoring the development of microorganisms. The allocthonous input of organic matter and microbes into the warm Neotropical caves may favor the development of filamentous fungi, including pathogenic species. Histoplasma capsulatum is a pathogenic species commonly found in caves and associated with bat and bird guano. Many Brazilian caves have been historically visited due to scenic and religious tourism. The objective of this study was to perform a microbiology study for a management plan of a show cave in Brazil, focusing on the presence and distribution of pathogenic and opportunistic fungi in the cave. Statistic analysis was used to verify the influence of touristic activity on airborne fungi spore load. Fungi were isolated from air and guano in Lapa Nova Cave. Samples were obtained through serial dilution, direct and settle plate techniques. For H. capsulatum, samples were incubated in specific media and conditions. Airborne fungal spore load was compared prior and during visitation and statistically analyzed. A total of 2,575 isolates from the genera Aspergillus, Calcarisporium, Chaetomium, Cladosporium, Curvularia, Emericella, Eurotium, Fusarium, Geotrichum, Gliocladium, Mucor, Purpureocillium, Paecilomyces, Penicillium, Rhizopus and Trichoderma were identified. Histoplasma capsulatum was not isolated from the cave. Eleven opportunistic species were identified. Significant (p<0.05 variations on fungal richness in the air occurred due to cave visitation. Areas of potential microbiologic risks were indicated and management actions suggested. The results suggest a diverse community inhabiting the cave. Possible opportunistic species should be monitored in show caves and microbiota should always be included in the elaboration of cave management plans. This is the first detailed microbiologic study for a management plan of a show cave in the country. It provides relevant information for future management plans.

  16. Metachronous metastasis- and survival-analysis show prognostic importance of lymphadenectomy for colon carcinomas

    Laubert Tilman

    2012-03-01

    Full Text Available Abstract Background Lymphadenectomy is performed to assess patient prognosis and to prevent metastasizing. Recently, it was questioned whether lymph node metastases were capable of metastasizing and therefore, if lymphadenectomy was still adequate. We evaluated whether the nodal status impacts on the occurrence of distant metastases by analyzing a highly selected cohort of colon cancer patients. Methods 1,395 patients underwent surgery exclusively for colon cancer at the University of Lbeck between 01/1993 and 12/2008. The following exclusion criteria were applied: synchronous metastasis, R1-resection, prior/synchronous second carcinoma, age Results Five-year survival rates for TM + and TM- were 21% and 73%, respectively (p Conclusions Besides a higher T-category, a positive N-stage independently implies a higher probability to develop distant metastases and correlates with poor survival. Our data thus show a prognostic relevance of lymphadenectomy which should therefore be retained until conclusive studies suggest the unimportance of lmyphadenectomy.

  17. Human responses to influenza vaccination show seroconversion signatures and convergent antibody rearrangements

    Jackson, Katherine J.L.; Liu, Yi; Roskin, Krishna M.; Glanville, Jacob; Hoh, Ramona A.; Seo, Katie; Marshall, Eleanor L.; Gurley, Thaddeus C.; Moody, M. Anthony; Haynes, Barton F.; Walter, Emmanuel B.; Liao, Hua-Xin; Albrecht, Randy A.; Garca-Sastre, Adolfo; Chaparro-Riggers, Javier; Rajpal, Arvind; Pons, Jaume; Simen, Birgitte B.; Hanczaruk, Bozena; Dekker, Cornelia L.; Laserson, Jonathan; Koller, Daphne; Davis, Mark M.; Fire, Andrew Z.; Boyd, Scott D.

    2014-01-01

    Summary B cells produce a diverse antibody repertoire by undergoing gene rearrangements. Pathogen exposure induces the clonal expansion of B cells expressing antibodies that can bind the infectious agent. To assess human B cell responses to trivalent seasonal influenza and monovalent pandemic H1N1 vaccination, we sequenced gene rearrangements encoding the immunoglobulin heavy chain, a major determinant of epitope recognition. The magnitude of B cell clonal expansions correlates with an individuals secreted antibody response to the vaccine and the expanded clones are enriched for those expressing influenza-specific mAbs. Additionally, B cell responses to pandemic influenza H1N1 vaccination and infection in different people show a prominent family of convergent antibody heavy chain gene rearrangements specific to influenza antigens. These results indicate that microbes can induce specific signatures of immunoglobulin gene rearrangements and that pathogen exposure can potentially be assessed from B cell repertoires. PMID:24981332

  18. Why does precipitation in northwest China show a significant increasing trend from 1960 to 2010?

    Li, Baofu; Chen, Yaning; Chen, Zhongsheng; Xiong, Heigang; Lian, Lishu

    2016-01-01

    Based on monthly precipitation data from 74 weather stations in the arid region of northwest China, we employed statistical methods to analyse the characteristics of precipitation and investigated the relationships between precipitation and 11 atmospheric circulations. The results showed that the precipitation in northwest China had a significantly increasing trend (P China (- 0.16 mm/year) for the same period. Annual precipitation increased markedly after 1987, but the increase in precipitation gradually declined from north to south and from west to east. We found that the precipitation variation in spring, summer, autumn, and winter plays an important role in the yearly change, accounting for 21.6%, 42.4%, 18.4%, and 17.6%, respectively. The correlation analysis indicated that the annual precipitation revealed strong and significant associations with the West Pacific Subtropical High (WPSH, R = 0.60, P China.

  19. Different methods to quantify Listeria monocytogenes biofilms cells showed different profile in their viability

    Lizziane Kretli, Winkelstrter; Elaine C.P. De, Martinis.

    2015-05-01

    Full Text Available Listeria monocytogenes is a foodborne pathogen able to adhere and to form biofilms in several materials commonly present in food processing plants. The aim of this study was to evaluate the resistance of Listeria monocytogenes attached to abiotic surface, after treatment with sanitizers, by culture [...] method, microscopy and Quantitative Real Time Polymerase Chain Reaction (qPCR). Biofilms of L. monocytogenes were obtained in stainless steel coupons immersed in Brain Heart Infusion Broth, under agitation at 37 C for 24 h. The methods selected for this study were based on plate count, microscopic count with the aid of viability dyes (CTC-DAPI), and qPCR. Results of culture method showed that peroxyacetic acid was efficient to kill sessile L. monocytogenes populations, while sodium hypochlorite was only partially effective to kill attached L. monocytogenes (p

  20. Not poles apart: Antarctic soil fungal communities show similarities to those of the distant Arctic.

    Cox, Filipa; Newsham, Kevin K; Bol, Roland; Dungait, Jennifer A J; Robinson, Clare H

    2016-05-01

    Antarctica's extreme environment and geographical isolation offers a useful platform for testing the relative roles of environmental selection and dispersal barriers influencing fungal communities. The former process should lead to convergence in community composition with other cold environments, such as those in the Arctic. Alternatively, dispersal limitations should minimise similarity between Antarctica and distant northern landmasses. Using high-throughput sequencing, we show that Antarctica shares significantly more fungi with the Arctic, and more fungi display a bipolar distribution, than would be expected in the absence of environmental filtering. In contrast to temperate and tropical regions, there is relatively little endemism, and a strongly bimodal distribution of range sizes. Increasing southerly latitude is associated with lower endemism and communities increasingly dominated by fungi with widespread ranges. These results suggest that micro-organisms with well-developed dispersal capabilities can inhabit opposite poles of the Earth, and dominate extreme environments over specialised local species. PMID:26932261

  1. Nuclear opinion poll shows increasing expectations and anxiety. Rad-waste management invites major concern

    1984-06-01

    The prime Minister's Office conducted a public opinion poll from March 1 to 7, 1984, in three areas: public recognition of nuclear energy, public recognition of nuclear power generation, and recognition of the safety of nuclear power generation. Public acceptance of nuclear power is essential for the smooth development of nuclear power generation. The interviewers met 2,252 people of total 3,000 selected by random sampling throughout the country. The results showed that the majority of the people recognize the necessity of developing oil-alternative energy, and hold expectation on the role and promotion of nuclear power as a main power source of future, but at the same time, they have some anxiety about the safety of nuclear power plants.

  2. Serological evidences showing the involvement of free-living pheasants in the influenza ecology

    Isabella Donatelli

    2010-01-01

    Full Text Available From 1995 to 2002, 219 sera were collected in Northern Italy from wild pheasants, in order to establish the possible involvement of these Galliformes birds in the influenza ecology. A serological survey for avian influenza viruses (AIVs was carried out by ELISA test in order to detect type A influenza antibodies. The overall seroprevalence was 12.3%, with yearly values ranging from 0% to 42.5%. No antibodies against either H5 or H7 AIV subtypes were found by hemagglutination-inhibition test. Data from 16 recaptured birds, among 113 animals banded for individual identification, showed seroconversions in 2 pheasants. Our results indicate AIV circulation in free-living pheasants; the involvement of this land-based bird species in influenza ecology is discussed.

  3. Visual evoked potentials show strong positive association with intracranial pressure in patients with cryptococcal meningitis

    Marcelo Adriano da Cunha Silva Vieira

    2015-04-01

    Full Text Available Objective : To verify the relationship between intracranial pressure and flash visual evoked potentials (F-VEP in patients with cryptococcal meningitis. Method The sample included adults diagnosed with cryptococcal meningitis admitted at a reference hospital for infectious diseases. The patients were subjected to F-VEP tests shortly before lumbar puncture. The Pearson?s linear correlation coefficient was calculated and the linear regression analysis was performed. Results : Eighteen individuals were subjected to a total of 69 lumbar punctures preceded by F-VEP tests. At the first lumbar puncture performed in each patient, N2 latency exhibited a strong positive correlation with intracranial pressure (r = 0.83; CI = 0.60 - 0.94; p < 0.0001. The direction of this relationship was maintained in subsequent punctures. Conclusion : The intracranial pressure measured by spinal tap manometry showed strong positive association with the N2 latency F-VEP in patients with cryptococcal meningitis.

  4. The parental negligence and relationship with disabilities: what does the national survey shows

    Mara Silvia Pasian

    2015-09-01

    Full Text Available Child maltreatment can cause several negative consequences for development, and, in certain situations, can be generated for any deficiency that child from neglect or violence generated against it, and some cases may lead to death. The objective of this study was to investigate material published in the Brazil involving the theme of maltreatment and child, specifically in the form of child neglect and somehow that addressed the terms disabilities or special needs. For this was made a search in databases and SCIELO LILACS, without restriction period, the articles selected are between the years 2000 and 2010. Then were selected and analyzed qualitatively 12 full articles. The results of this research show that the analyzed articles centered on the theme of the description of the types of abuse and the need for increased awareness and reporting of cases involving child abuse, two articles address the relationship of child maltreatment and disability, showing significant vulnerability of children with disabilities for the occurrence of parental abuse or neglect. The considerations point to the need research production and dissemination of studies involving the issue of child neglect and the individual with special needs, focusing consequences and prevention measures.

  5. Alectinib shows potent antitumor activity against RET-rearranged non-small cell lung cancer.

    Kodama, Tatsushi; Tsukaguchi, Toshiyuki; Satoh, Yasuko; Yoshida, Miyuki; Watanabe, Yoshiaki; Kondoh, Osamu; Sakamoto, Hiroshi

    2014-12-01

    Alectinib/CH5424802 is a known inhibitor of anaplastic lymphoma kinase (ALK) and is being evaluated in clinical trials for the treatment of ALK fusion-positive non-small cell lung cancer (NSCLC). Recently, some RET and ROS1 fusion genes have been implicated as driver oncogenes in NSCLC and have become molecular targets for antitumor agents. This study aims to explore additional target indications of alectinib by testing its ability to inhibit the activity of kinases other than ALK. We newly verified that alectinib inhibited RET kinase activity and the growth of RET fusion-positive cells by suppressing RET phosphorylation. In contrast, alectinib hardly inhibited ROS1 kinase activity unlike other ALK/ROS1 inhibitors such as crizotinib and LDK378. It also showed antitumor activity in mouse models of tumors driven by the RET fusion. In addition, alectinib showed kinase inhibitory activity against RET gatekeeper mutations (RET V804L and V804M) and blocked cell growth driven by the KIF5B-RET V804L and V804M. Our results suggest that alectinib is effective against RET fusion-positive tumors. Thus, alectinib might be a therapeutic option for patients with RET fusion-positive NSCLC. PMID:25349307

  6. Canonical Wnts, specifically Wnt-10b, show ability to maintain dermal papilla cells

    Ouji, Yukiteru, E-mail: oujix@naramed-u.ac.jp; Nakamura-Uchiyama, Fukumi; Yoshikawa, Masahide, E-mail: myoshika@naramed-u.ac.jp

    2013-08-30

    Highlights: •First report on effects of various Wnts on DP cells. •Wnt-10b promoted trichogenesis, while Wnt-3a showed to a limited extent. •Canonical Wnts, specifically Wnt-10b, is important for DP cells maintenance. -- Abstract: Although Wnts are expressed in hair follicles (HFs) and considered to be crucial for maintaining dermal papilla (DP) cells, the functional differences among them remain largely unknown. In the present study, we investigated the effects of Wnts (Wnt-3a, 5a, 10b, 11) on the proliferation of mouse-derived primary DP cells in vitro as well as their trichogenesis-promoting ability using an in vivo skin reconstitution protocol. Wnt-10b promoted cell proliferation and trichogenesis, while Wnt-3a showed those abilities to a limited extent, and Wnt-5a and 11 had no effects. Furthermore, we investigated the effects of these Wnts on cultured DP cells obtained from versican-GFP transgenic mice and found that Wnt-10b had a potent ability to sustain their GFP-positivity. These results suggest that canonical Wnts, specifically Wnt-10b, play important roles in the maintenance of DP cells and trichogenesis.

  7. Fundamental mathematical model shows that applied electrical field enhances chemotherapy delivery to tumors.

    Moarefian, Maryam; Pascal, Jennifer A

    2016-02-01

    Biobarriers imposed by the tumor microenvironment create a challenge to deliver chemotherapeutics effectively. Electric fields can be used to overcome these biobarriers in the form of electrochemotherapy, or by applying an electric field to tissue after chemotherapy has been delivered systemically. A fundamental understanding of the underlying physical phenomena governing tumor response to an applied electrical field is lacking. Building upon the work of Pascal et al. [1], a mathematical model that predicts the fraction of tumor killed due to a direct current (DC) applied electrical field and chemotherapy is developed here for tumor tissue surrounding a single, straight, cylindrical blood vessel. Results show the typical values of various parameters related to properties of the electrical field, tumor tissue and chemotherapy drug that have the most significant influence on the fraction of tumor killed. We show that the applied electrical field enhances tumor death due to chemotherapy and that the direction and magnitude of the applied electrical field have a significant impact on the fraction of tumor killed. PMID:26656676

  8. Ibuprofen reverts antifungal resistance on Candida albicans showing overexpression of CDR genes.

    Ricardo, Elisabete; Costa-de-Oliveira, Sofia; Dias, Ana Silva; Guerra, José; Rodrigues, Acácio Gonçalves; Pina-Vaz, Cidália

    2009-06-01

    Several mechanisms may be associated with Candida albicans resistance to azoles. Ibuprofen was described as being able to revert resistance related to efflux activity in Candida. The aim of this study was to uncover the molecular base of antifungal resistance in C. albicans clinical strains that could be reverted by ibuprofen. Sixty-two clinical isolates and five control strains of C. albicans were studied: the azole susceptibility phenotype was determined according to the Clinical Laboratory for Standards Institute, M27-A2 protocol and minimal inhibitory concentration values were recalculated with ibuprofen (100 microg mL(-1)); synergistic studies between fluconazole and FK506, a Cdr1p inhibitor, were performed using an agar disk diffusion assay and were compared with ibuprofen results. Gene expression was quantified by real-time PCR, with and without ibuprofen, regarding CDR1, CDR2, MDR1, encoding for efflux pumps, and ERG11, encoding for azole target protein. A correlation between susceptibility phenotype and resistance gene expression profiles was determined. Ibuprofen and FK506 showed a clear synergistic effect when combined with fluconazole. Resistant isolates reverting to susceptible after incubation with ibuprofen showed CDR1 and CDR2 overexpression especially of the latter. Conversely, strains that did not revert displayed a remarkable increase in ERG11 expression along with CDR genes. Ibuprofen did not alter resistance gene expression significantly (P>0.05), probably acting as a Cdrp blocker. PMID:19416368

  9. African elephants show high levels of interest in the skulls and ivory of their own species.

    McComb, Karen; Baker, Lucy; Moss, Cynthia

    2006-03-22

    An important area of biology involves investigating the origins in animals of traits that are thought of as uniquely human. One way that humans appear unique is in the importance they attach to the dead bodies of other humans, particularly those of their close kin, and the rituals that they have developed for burying them. In contrast, most animals appear to show only limited interest in the carcasses or associated remains of dead individuals of their own species. African elephants (Loxodonta africana) are unusual in that they not only give dramatic reactions to the dead bodies of other elephants, but are also reported to systematically investigate elephant bones and tusks that they encounter, and it has sometimes been suggested that they visit the bones of relatives. Here, we use systematic presentations of object arrays to demonstrate that African elephants show higher levels of interest in elephant skulls and ivory than in natural objects or the skulls of other large terrestrial mammals. However, they do not appear to specifically select the skulls of their own relatives for investigation so that visits to dead relatives probably result from a more general attraction to elephant remains. PMID:17148317

  10. [Twelve-month-old infants show social preferences for native-dialect speakers].

    Okumura, Yuko; Kanakogi, Yasuhiro; Takeuchi, Sachie; Itakura, Shoji

    2014-08-01

    Recent research demonstrates that social preferences for native language speakers emerge early in development, indicating that infants prefer speakers from their own society. Dialect may also be a reliable cue to group membership because it provides information about an individual's social and ethnic identity. We investigated whether infants showed social preferences toward native-dialect speakers over those with unfamiliar dialects. Infants at 9 and 12 months of age were shown videos in which two adults (a native-dialect speaker and an unfamiliar-dialect speaker) each spoke to and then offered an identical toy to the participating infants. Next, two real versions of the toys were presented to the infants in person. The 12-month-old infants preferentially reached for the toy offered by the native-dialect speaker. The 9-month-old infants also showed a preference for native-dialect speakers but this finding was not statistically significant. Our results suggest that dialects may be a reliable cue to group membership, and that infants' orientation toward members of their native community may guide their social and cultural learning. PMID:25272442

  11. Genetics Show Current Decline and Pleistocene Expansion in Northern Spotted Owls

    Funk, W. Chris; Forsman, Eric D.; Mullins, Thomas D.; Haig, Susan M.

    2008-01-01

    The northern spotted owl (Strix occidentalis caurina) is one of the most controversial threatened subspecies ever listed under the U.S. Endangered Species Act. Because of concern for persistence of the subspecies, logging on Federal lands in the U.S. Pacific Northwest was dramatically reduced under the Northwest Forest Plan in 1994. Despite protection of its remaining forest habitat, recent field studies show continued demographic declines of northern spotted owls. One potential threat to northern spotted owls that has not yet been shown is loss of genetic variation from population bottlenecks that can increase inbreeding depression and decrease adaptive potential. Here, we show recent genetic bottlenecks in northern spotted owls using a large genetic dataset (352 individuals from across the subspecies' range and 11 microsatellite loci). The signature of bottlenecks was strongest in Washington State, in agreement with field data. Interestingly, we also found a genetic signature of Pleistocene expansion in the same study areas where recent bottlenecks were shown. Our results provide independent evidence that northern spotted owls have recently declined, and suggest that loss of genetic variation is an emerging threat to the subspecies' persistence. Reduced effective population size (Ne), shown here in addition to field evidence for demographic decline, highlights the increasing vulnerability of this bird to extinction.

  12. Transchromosomic cell model of Down syndrome shows aberrant migration, adhesion and proteome response to extracellular matrix

    Cotter Finbarr E

    2009-08-01

    Full Text Available Abstract Background Down syndrome (DS, caused by trisomy of human chromosome 21 (HSA21, is the most common genetic birth defect. Congenital heart defects (CHD are seen in 40% of DS children, and >50% of all atrioventricular canal defects in infancy are caused by trisomy 21, but the causative genes remain unknown. Results Here we show that aberrant adhesion and proliferation of DS cells can be reproduced using a transchromosomic model of DS (mouse fibroblasts bearing supernumerary HSA21. We also demonstrate a deacrease of cell migration in transchromosomic cells independently of their adhesion properties. We show that cell-autonomous proteome response to the presence of Collagen VI in extracellular matrix is strongly affected by trisomy 21. Conclusion This set of experiments establishes a new model system for genetic dissection of the specific HSA21 gene-overdose contributions to aberrant cell migration, adhesion, proliferation and specific proteome response to collagen VI, cellular phenotypes linked to the pathogenesis of CHD.

  13. Female rats exposed to stress and alcohol show impaired memory and increased depressive-like behaviors.

    Gomez, J L; Luine, V N

    2014-01-17

    Exposure to daily life stressors is associated with increases in anxiety, depression, and overall negative affect. Alcohol or other psychoactive drugs are often used to alleviate stress effects. While females are more than twice as likely to develop mood disorders and are more susceptible to dependency than males, they are infrequently examined. In this study, female rats received no stress/no alcohol control (CON), alcohol alone (ALC), stress alone (STR), or stress plus alcohol (STR+ALC). Stress consisted of restraint for 6h/day/7days, and alcohol was administered immediately following restraint via gastric gavage at a dose of 2.0g/kg. Dependent measures included tests utilizing object recognition (OR), Y-maze, elevated plus maze (EPM), forced swim (FST), blood alcohol content, corticosterone levels, and body weights. ALC, STR+ALC, but not stress alone, impaired memory on OR. All treatments impaired spatial memory on the Y-maze. Anxiety was not affected on the EPM, but rats treated with alcohol or in combination with stress showed increased immobility on the FST, suggestive of alcohol-induced depression. Previously, we found alcohol reversed deleterious effects of stress on memory and mood in males, but current results show that females reacted negatively when the two treatments were combined. Thus, responses to alcohol, stress and their combination suggest that sex specific treatments are needed for stress-induced behavioral changes and that self-medicating with alcohol to cope with stress maybe deleterious in females. PMID:24096191

  14. Bacterial biofilm shows persistent resistance to liquid wetting and gas penetration

    Epstein, Alexander K.; Pokroy, Boaz; Seminara, Agnese; Aizenberg, Joanna (Harvard)

    2011-09-28

    Most of the world's bacteria exist in robust, sessile communities known as biofilms, ubiquitously adherent to environmental surfaces from ocean floors to human teeth and notoriously resistant to antimicrobial agents. We report the surprising observation that Bacillus subtilis biofilm colonies and pellicles are extremely nonwetting, greatly surpassing the repellency of Teflon toward water and lower surface tension liquids. The biofilm surface remains nonwetting against up to 80% ethanol as well as other organic solvents and commercial biocides across a large and clinically important concentration range. We show that this property limits the penetration of antimicrobial liquids into the biofilm, severely compromising their efficacy. To highlight the mechanisms of this phenomenon, we performed experiments with mutant biofilms lacking ECM components and with functionalized polymeric replicas of biofilm microstructure. We show that the nonwetting properties are a synergistic result of ECM composition, multiscale roughness, reentrant topography, and possibly yet other factors related to the dynamic nature of the biofilm surface. Finally, we report the impenetrability of the biofilm surface by gases, implying defense capability against vapor-phase antimicrobials as well. These remarkable properties of B. subtilis biofilm, which may have evolved as a protection mechanism against native environmental threats, provide a new direction in both antimicrobial research and bioinspired liquid-repellent surface paradigms.

  15. Gastric cancers of Western European and African patients show different patterns of genomic instability

    Mulder Chris JJ

    2011-01-01

    Full Text Available Abstract Background Infection with H. pylori is important in the etiology of gastric cancer. Gastric cancer is infrequent in Africa, despite high frequencies of H. pylori infection, referred to as the African enigma. Variation in environmental and host factors influencing gastric cancer risk between different populations have been reported but little is known about the biological differences between gastric cancers from different geographic locations. We aim to study genomic instability patterns of gastric cancers obtained from patients from United Kingdom (UK and South Africa (SA, in an attempt to support the African enigma hypothesis at the biological level. Methods DNA was isolated from 67 gastric adenocarcinomas, 33 UK patients, 9 Caucasian SA patients and 25 native SA patients. Microsatellite instability and chromosomal instability were analyzed by PCR and microarray comparative genomic hybridization, respectively. Data was analyzed by supervised univariate and multivariate analyses as well as unsupervised hierarchical cluster analysis. Results Tumors from Caucasian and native SA patients showed significantly more microsatellite instable tumors (p Conclusions Gastric cancers from SA and UK patients show differences in genetic instability patterns, indicating possible different biological mechanisms in patients from different geographical origin. This is of future clinical relevance for stratification of gastric cancer therapy.

  16. Transgenic poplar expressing the pine GS1a show alterations in nitrogen homeostasis during drought.

    Molina-Rueda, Juan Jesús; Kirby, Edward G

    2015-09-01

    Transgenic hybrid poplars engineered to express ectopically the heterologous pine cytosolic GS1a display a number of significant pleiotropic phenotypes including enhanced growth, enhanced nitrogen use efficiency, and resistance to drought stress. The present study was undertaken in order to assess mechanisms whereby ectopic expression of pine GS1a in transgenic poplars results in enhanced agronomic phenotypes. Microarray analysis using the Agilent Populus whole genome array has allowed identification of genes differentially expressed between wild type (WT) and GS transgenics in four tissues (sink leaves, source leaves, stems, and roots) under three growth conditions (well-watered, drought, and recovery). Analysis revealed that differentially expressed genes in functional categories related to nitrogen metabolism show a trend of significant down-regulation in GS poplars compared to the WT, including genes encoding nitrate and nitrite reductases. The down-regulation of these genes was verified using qPCR, and downstream effects were further tested using NR activity assays. Results suggest that higher glutamine levels in GS transgenics regulate nitrate uptake and reduction. Transcript levels of nitrogen-related genes in leaves, including GS/GOGAT cycle enzymes, aspartate aminotransferase, GABA shunt enzymes, photorespiration enzymes, asparagine synthetase, phenylalanine ammonia lyase, isocitrate dehydrogenase, and PII, were also assessed using qPCR revealing significant differences between GS poplars and the WT. Moreover, metabolites related to these differentially expressed genes showed alterations in levels, including higher levels of GABA, hydroxyproline, and putrescine in the GS transgenic. These alterations in nitrogen homeostasis offer insights into mechanisms accounting for drought tolerance observed in GS poplars. PMID:26113157

  17. Nav 1.8-null mice show stimulus-dependent deficits in spinal neuronal activity

    Wood John N

    2006-02-01

    Full Text Available Abstract Background The voltage gated sodium channel Nav 1.8 has a highly restricted expression pattern to predominantly nociceptive peripheral sensory neurones. Behaviourally Nav 1.8-null mice show an increased acute pain threshold to noxious mechanical pressure and also deficits in inflammatory and visceral, but not neuropathic pain. Here we have made in vivo electrophysiology recordings of dorsal horn neurones in intact anaesthetised Nav 1.8-null mice, in response to a wide range of stimuli to further the understanding of the functional roles of Nav 1.8 in pain transmission from the periphery to the spinal cord. Results Nav 1.8-null mice showed marked deficits in the coding by dorsal horn neurones to mechanical, but not thermal, -evoked responses over the non-noxious and noxious range compared to littermate controls. Additionally, responses evoked to other stimulus modalities were also significantly reduced in Nav 1.8-null mice where the reduction observed to pinch > brush. The occurrence of ongoing spontaneous neuronal activity was significantly less in mice lacking Nav 1.8 compared to control. No difference was observed between groups in the evoked activity to electrical activity of the peripheral receptive field. Conclusion This study demonstrates that deletion of the sodium channel Nav 1.8 results in stimulus-dependent deficits in the dorsal horn neuronal coding to mechanical, but not thermal stimuli applied to the neuronal peripheral receptive field. This implies that Nav 1.8 is either responsible for, or associated with proteins involved in mechanosensation.

  18. Phylogenomic analysis shows that ‘Bacillus vanillea’ is a later heterotypic synonym of Bacillus siamensis.

    Dunlap, Christopher A

    2015-10-01

    ‘Bacillus vanillea’ XY18 ( = CGMCC 8629 = NCCB 100507) was isolated from cured vanilla beans and involved in the formation of vanilla aroma compounds. A draft genome of this strain was assembled and yielded a length of 3.71 Mbp with a DNA G+C content of 46.3 mol%. Comparative genomic analysis with its nearest relatives showed only minor differences between this strain and the genome of the Bacillus siamensis KCTC 13613T ( = BCC 22614T = KACC 16244T), with a calculated DNA–DNA hybridization (DDH) value of 91.2 % and an average nucleotide identity (ANI) of 98.9 %. This DDH value is well above the recommended 70 % threshold for species delineation, as well as the ANI threshold of 95 %. In addition, the results of morphological, physiological, chemotaxonomic and phylogenetic analyses indicate that the type strains of these two taxa are highly similar with phenotype coherence. A core genome multi-locus sequencing analysis was conducted for the strains and the results show that ‘Bacillus vanillea’ XY18 clusters closely to the type strain of Bacillus siamensis. Therefore, it is proposed that the species ‘Bacillus vanillea’ XY18 ( = CGMCC 8629 = NCCB 100507) should be reclassified as a later heterotypic synonym of Bacillus siamensis KCTC 13613T ( = BCC 22614T = KACC 16244T). An emended description of Bacillus siamensis is provided. PMID:26296875

  19. Ipomoea aquatica Extract Shows Protective Action Against Thioacetamide-Induced Hepatotoxicity

    A. Hamid A. Hadi

    2012-05-01

    Full Text Available In the Indian system of traditional medicine (Ayurveda it is recommended to consume Ipomoea aquatica to mitigate disorders like jaundice. In this study, the protective effects of ethanol extract of I. aquatica against liver damage were evaluated in thioacetamide (TAA-induced chronic hepatotoxicity in rats. There was no sign of toxicity in the acute toxicity study, in which Sprague-Dawley (SD rats were orally fed with I. aquatica (250 and 500 mg/kg for two months along with administration of TAA (i.p injection 200 mg/kg three times a week for two months. The results showed that the treatment of I. aquatica significantly lowered the TAA-induced serum levels of hepatic enzyme markers (ALP, ALT, AST, protein, albumin, bilirubin and prothrombin time. The hepatic content of activities and expressions SOD and CAT that were reduced by TAA were brought back to control levels by the plant extract supplement. Meanwhile, the rise in MDA level in the TAA receiving groups also were significantly reduced by I. aquatica treatment. Histopathology of hepatic tissues by H&E and Masson trichrome stains displayed that I. aquatica has reduced the incidence of liver lesions, including hepatic cells cloudy swelling, infiltration, hepatic necrosis, and fibrous connective tissue proliferation induced by TAA in rats. Therefore, the results of this study show that the protective effect of I. aquatica in TAA-induced liver damage might be contributed to its modulation on detoxification enzymes and its antioxidant and free radical scavenger effects. Moreover, it confirms a scientific basis for the traditional use of I. aquatica for the treatment of liver disorders.

  20. Gefitinib (IRESSA) sensitive lung cancer cell lines show phosphorylation of Akt without ligand stimulation

    Noro, Rintaro; Gemma, Akihiko; Kosaihira, Seiji; Kokubo, Yutaka; Chen, Mingwei; Seike, Masahiro; Kataoka, Kiyoko; Matsuda, Kuniko; Okano, Tetsuya; Minegishi, Yuji; Yoshimura, Akinobu; Kudoh, Shoji

    2006-01-01

    Background Phase III trials evaluating the efficacy of gefitinib (IRESSA) in non-small cell lung cancer (NSCLC) lend support to the need for improved patient selection in terms of gefitinib use. Mutation of the epidermal growth factor receptor (EGFR) gene is reported to be associated with clinical responsiveness to gefitinib. However, gefitinib-sensitive and prolonged stable-disease-defined tumors without EGFR gene mutation have also been reported. Methods To identify other key factors involved in gefitinib sensitivity, we analyzed the protein expression of molecules within the EGFR family, PI3K-Akt and Ras/MEK/Erk pathways and examined the sensitivity to gefitinib using the MTT cell proliferation assay in 23 lung cancer cell lines. Results We identified one highly sensitive cell line (PC9), eight cell lines displaying intermediate-sensitivity, and 14 resistant cell lines. Only PC9 and PC14 (intermediate-sensitivity) displayed an EGFR gene mutation including amplification. Eight out of the nine cell lines showing sensitivity had Akt phosphorylation without ligand stimulation, while only three out of the 14 resistant lines displayed this characteristic (P = 0.0059). Furthermore, the ratio of phosphor-Akt/total Akt in sensitive cells was higher than that observed in resistant cells (P = 0.0016). Akt phosphorylation was partially inhibited by gefitinib in all sensitive cell lines. Conclusion These results suggest that Akt phosphorylation without ligand stimulation may play a key signaling role in gefitinib sensitivity, especially intermediate-sensitivity. In addition, expression analyses of the EGFR family, EGFR gene mutation, and FISH (fluorescence in situ hybridization) analyses showed that the phosphorylated state of EGFR and Akt might be a useful clinical marker of Akt activation without ligand stimulation, in addition to EGFR gene mutation and amplification, particularly in adenocarcinomas. PMID:17150102

  1. Results from LEP

    Selected results from LEP on electroweak neutral currents and strong interactions are reviewed. In the first part, total cross sections, angular and polarization symmetries are interpreted in terms of basic electroweak parameters, like the mass, total and partial widths of the Z and neutral current couplings. Special attention is given to two apparent problems: the discrepancy between the measurements with final state vs. initial state polarization; and the deviation of the measured width of the Z into heavy quarks from Standard Model expectations. These discrepancies are not very significant, but they are the only ones observed at this point and thus deserve attention. In the second part, I outline results on final state strong interactions, namely measurements pertaining to differences between quark and gluon jets and the QCD group structure. (author) 19 figs., 4 tabs., 21 refs

  2. Recent results from HELIOS

    Back B. B.

    2011-10-01

    Full Text Available Transfer and inelastic scattering reactions using light-ion beams and stable or long-lived targets have traditionally provided detailed information on the structure of nuclei near the line of beta stability. Such studies can now be extended to nuclei away from the line of β-stability as radioactive beams are becoming available at a number of facilities around the world, including the CARIBU facility at Argonne. These measurements must, however, be carried out in inverse kinematics, resulting in a loss of the effective experimental resolution when conventional detection schemes are employed. The HELIOS spectrometer is based on a new concept, that is especially well suited for such studies by reducing the resolution problem, providing simple particle identification, and giving high detection efficiency with moderate Si detector area. In this talk, the HELIOS concept and results from the first series of experiments will be presented.

  3. Experimental results from Stripa

    The results indicate that the temperature fields in a rock mass containing geologic discontinuities can be predicted accurately using the simple theory of heat conduction. Geologic discontinuities appear to introduce significant nonlinear thermomechanical deformation into the rock mass, as a result of which the thermally induced displacements are much less than those predicted by the simple theory of thermo-elasticity. In addition, the assumption that the rock properties are temperature independent appears to increase the values predicted for these displacements significantly. Therefore, it is important that the temperature dependence of these properties is known and that these values be used in the calculations. The onset of significant thermal spalling along the walls of the heater boreholes appears to be related to conditions where the maximum induced compressive stress exceeds the uniaxial compressive strength of the rock. 7 figures

  4. Solar results purchasing

    Solar Thermal water heating has made little market penetration in some European countries. The main barriers to market development are: Long payback periods for the technology; Difficulties for the end-user in meeting the initial capital costs of the installation; Lack of confidence in the delivered energy that can be expected from the technology. The third barrier has been addressed using the concept of Guaranteed Solar Results (GSR). This project has addressed the other two main barriers using the concept of Solar Results Purchasing, (SRP) which combines GSR with Third Party Financing. The work was carried out in the UK, France, and Spain. The project used a uniform approach across the three countries. Each team calculated solar performance using an English version of the SOLO programme developed by TECSOL in France to encode the methodology for GSR model contracts. (author)

  5. Envirhom: stakes and results

    After a recall of the evolution of the international system for the protection against ionizing radiations, this report discusses the evolution of a new societal context (evolution of risk perception, concern about accidental situations). It also discusses the emerging scientific issues and challenges regarding the knowledge about biological and health effects of ionizing radiations, which requires investigations on the ecosystems, the effects of chronic low level exposures, and the propagation of effects at different biological levels (cells, tissue, individual, population, communities, and ecosystems). Then, it presents the IRSN environment-health research program, ENVIRHOM, its objectives, and its results concerning the environment on the one side, and health on the other side. The 'environment' side and the 'health' side of this program are then more precisely presented as well as their results

  6. Recent results from CMS

    Schöfbeck Robert

    2015-01-01

    Full Text Available The CMS experiment at the Large Hadron Collider at CERN collected a dataset of 19.5fb−1 during 8 TeV proton-proton operation. A large number of groundbreaking results were obtained from the analysis of this dataset, among them the discovery of the Higgs boson and precision measurements of important Standard Model parameters, for example the mass of the top quark. Subtle processes like the production of a Z boson by fusion of two W bosons have been measured for the first time. Moreover, many searches for physics beyond the Standard model have been carried out, both in the context of supersymmetry and beyond, which often provide tight constraints in model parameter space. This brief summary is a a short overview of the most important recent CMS results at 7 and 8 TeV.

  7. Results from PLUTO

    Results on the reaction e+ e- → μ+ μ- are presented. The data were taken with the PLUTO detector at the c.m. energy of 34.7 GeV. In the integrated luminosity of 44000 nb-1 taken, a forward backward asymmetry of -(12.0 + or - 3.2)% is observed for abs. value costheta <1 which is in agreement with the standard model

  8. Review of Unquenched Results

    Mawhinney, Robert D

    2000-01-01

    One of the major frontiers of lattice field theory is the inclusion of light fermions in simulations, particularly in pursuit of accurate, first principles predictions from lattice QCD. With dedicated Teraflops-scale computers currently simulating QCD, another step towards precision full QCD simulations is underway. In addition to ongoing staggered and Wilson fermion simulations, first results from full QCD with domain wall fermions are available. After some discussion of work toward better algorithms, simulations completed to date will be discussed.

  9. Recent results from LEP

    A Gurtu

    2000-04-01

    Recent results from the LEP collider at CERN are presented: on the identification of +- → +- and the determination of the mass and width and limits on its anomalous couplings; the search for the Standard Model and non-minimal Higgs; search for SUSY and other new particles. Fits to all electroweak data leading to predictions of the Higgs mass within the Standard Model are presented.

  10. Theoretical Results on Neutrinos

    Zhou, Shun

    2015-01-01

    In this talk, I first summarize our current knowledge about the fundamental properties of neutrinos and emphasize the remaining unsolved problems in neutrino physics. Then, recent theoretical results on neutrino mass models are introduced. Different approaches to understanding tiny neutrino masses, lepton flavor mixing and CP violation are presented. Finally, I report briefly some new progress in the studies of astrophysical neutrinos, including keV sterile neutrinos, supernova neutrinos and ...

  11. Assessing ultrasonic examination results

    Amongst nondestructive examination methods, the ultrasonic examination plays an important role. The reason why its scope of application is so wide is because the sound conducting capacity is the only property the material of a test specimen has to have. As the fields are so manifold, only main aspects can be described briefly. The list of references, however, is very extensive and gives plenty of information of all the problems concerning the assessment of ultrasonic examination results. (orig./RW)

  12. New results from DELCO

    New results from the DELCO experiment at SPEAR are presented. New data and reanalysis give conclusive evidence for the tau heavy lepton with mass 1.777 + 0.005 - 0.009 GeV/c2. Preliminary branching ratios for the tau are discussed, along with analysis of the electron momentum spectrum, favoring V-A. A preliminary look at D beta decay at psi''(3770) in terms of K and K*(890) is also discussed

  13. Enova. Result Report 2003

    Enova is a state enterprise owned by the Oil and Energy Department, and it has been operative since 1st of January 2002. Its main objective is to work for the advancement of a more environmental energy consumption and energy production in Norway. 500 million NOK are annually administered by Enova and allocated to different energy projects. A brief account of the results from 2003 is presented

  14. Enova. Result Report 2004

    Enova is a state enterprise owned by the Oil and Energy Department, and has been operative since 1st of January 2002. Its main vision is to be a driving force for future-oriented energy solutions. The Energy fund is administered by Enova, and the resources are distributed to different projects that contribute to energy savings and new, environmental technology. A brief account of the results from 2004 is presented

  15. Space Shuttle radargrammetry results

    Leberl, F.; Domik, G.; Raggam, J.; Cimino, J.; Kobrick, M.

    1986-01-01

    Preliminary results on the radargrammetric processing of SIR-A and SIR-B data are presented. Radargrammetric processing was applied to images of the Trinity National Forest in Northern California, the islands of Cephalonia, Ithaka, and Sardegna, Mt. Shasta, and Cordon La Grasa, Argentina. The preliminary processing of the SIR-A and SIR-B data has produced digital elevation models, stereo models, and a contour map.

  16. New results from CERES

    Marin, A.; Collaboration, for the CERES

    2004-01-01

    During the year 2000 the CERES experiment, upgraded with a radial drift TPC, took a large data sample of Pb on Au collisions at 158 AGeV triggered on the 8% most central collisions. A very detailed calibration of the radial drift TPC was since completed. Preliminary results on $e^+e^-$ pairs and $\\phi$ mesons reconstructed in the $K^+K^-$ channel are presented.

  17. Theoretical Results on Neutrinos

    Zhou, Shun

    2015-01-01

    In this talk, I first summarize our current knowledge about the fundamental properties of neutrinos and emphasize the remaining unsolved problems in neutrino physics. Then, recent theoretical results on neutrino mass models are introduced. Different approaches to understanding tiny neutrino masses, lepton flavor mixing and CP violation are presented. Finally, I report briefly some new progress in the studies of astrophysical neutrinos, including keV sterile neutrinos, supernova neutrinos and ultrahigh-energy cosmic neutrinos.

  18. Recent results from CERES

    A di-electron spectrum, measured by CERES in Pb-Au collisions at 40 GeV per nucleon, exhibits an enhancement over the level expected from hadron decays. The enhancement is similar to the one seen previously in the data acquired with the full SPS energy. In addition, the upgraded CERES allows for high statistics hadron measurements. Some results from these measurements at various beam energies are presented. (orig.)

  19. Results from SAGE

    The Russian-American Gallium Solar Neutrino Experiment (SAGE) is described. Beginning in September 1992, SAGE II data were taken with 55 tons of Ga and with significantly reduced backgrounds. The solar neutrino flux measured by 31 extractions through October 1993 is presented. The result of 69 ± 10 +5/-7 SNU is to be compared with a Standard Solar Model prediction of 132 SNU

  20. EXO-200 results

    Status update and recent results from a second low background run of the double beta decay search experiment EXO 200 are presented here. Detector is a liquid xenon TPC with charge and light readout located underground in low-background environment (1600 m.w.e.). It contains 175 kg of xenon with 80.6 % abundance of 136Xe. Data was taken from September 2011 till April 2012 and have total exposure of 32.5 kgy. New enhanced signal reconstruction and estimation of energy from combined ionization and scintillation signals allowed to improve energy resolution dramatically. Analysis of new data results in a half-life for a 2β2ν decay mode of 2.23 central dot 1021 years that completely agree with previous value and with results of experiment KamLAND-Zen. Also are set a new limit for a 2β0ν mode equal to 1.6 central dot 1025 (90 % C.L.) and world-leading limit on effective Majorana neutrino mass

  1. Recent CMS Results

    Dorigo, Tommaso

    2012-01-01

    The CMS experiment obtained a large number of groundbreaking results from the analysis of 7- and 8-TeV proton-proton collisions produced so far by the Large Hadron Collider at CERN. In this brief summary only a sample of those results will be discussed. A new particle with mass m(H) = 125.3 +- 0.4(stat.) +- 0.5(syst.) GeV and characteristics compatible with those expected for a standard model Higgs boson has been observed in its decays to photon pairs, WW pairs, and ZZ pairs. Searches for the rare decays B_d -> mu mu and B_s -> mu mu have allowed to set limits on the branching fractions which are close to standard model predictions, strongly constraining new physics models. The top quark has been studied with great detail, obtaining among other results the world's best measurement of its mass as m(top) = 173.49 +- 0.43(stat. + JES) +- 0.98(syst.) GeV. New physics models have been strongly constrained with the available data.

  2. GIRAFFE test results summary

    Yokobori, S.; Arai, K.; Oikawa, H. [Toshiba Corporation, Kawasaki (Japan)

    1996-03-01

    A passive system can provide engineered safety features enhancing safety system reliability and plant simplicity. Toshiba has conducted the test Program to demonstrate the feasibility of the SBWR passive safety system using a full-height, integral system test facility GIRAFFE. The test facility GIRAFFE models the SBWR in full height to correctly present the gravity driving head forces with a 1/400 volume scale. The GIRAFFE test Program includes the certification tests of the passive containment cooling system (PCCS) to remove the post-accident decay heat and the gravity driven cooling system (GDCS) to replenish the reactor coolant inventory during a LOCA. The test results have confirmed the PCCS and GDCS design and in addition, have demonstrated the operation of the pCCS with the presence of a lighter-than-steam noncondensable as well as with the presence of a heavier-than-steam, noncondensable. The GIRAFFE test Program has also provided the database to qualify a best estimate thermal-hydraulic computer code TRAC. The post test analysis results have shown that TRAC can accurately predict the PCCS heat removal Performance and the containment pressure response to a LOCA. This paper summarizes the GIRAFFE test results to investigate post-LOCA PCCS heat removal performance and post-test analysis using TRAC.

  3. Semimembranosus tenosynovitis: operative results.

    Halperin, N; Oren, Y; Hendel, D; Nathan, N

    1987-01-01

    Semimembranosus tenosynovitis is a common knee problem in the over-50 age-group, occurring mainly in women. It affects the reflected portion of the tendon of the semimembranosus muscle as well as the bursa below it. The tendon becomes inflamed as a result of friction at the entrance to the bony canal (semimembranosus groove), especially if osteophytes are present on the edges of the groove. Conservative treatment includes anti-inflammatory drugs, ultrasound, and friction massage. If necessary, nonresponders may be given local injection of 40-80 mg methylprednisolone acetate with 1% Xylocaine. Between 1979 and 1983 we operated on 16 patients who had not obtained relief even after three or four injections. The approach in each case was through a posterior medial oblique incision. The semimembranosus osteofibrotic tunnel was revealed and the fibrous sheath surrounding the tendon was excised. Good results were obtained in eight patients in whom the inflammatory process had been localized to only the semimembranosus insertion area: eight patients in whom the knee joint or the pes anserinus insertion was also involved achieved fair or poor results. The operation is not advised for young athletes because of the important function of the reflected head of the semimembranosus muscle. PMID:3632312

  4. Streamwater ages derived from tritium show power law variation with discharge like silica concentrations

    Stewart, Michael; Morgenstern, Uwe

    2013-04-01

    Understanding runoff generation is important for management of freshwater systems. Determining transit time distributions of streamwaters and how they change with discharge gives information on the flowpaths and recharge sources of streams - vital information for determining the responses of streams to stressors such as pollution, landuse change, or climate change. This work takes a first look at unique information on how transit time distributions change with discharge in some New Zealand catchments. Transit time distributions of streamwaters have been determined from tritium measurements on single samples in this work. This allows changes with stream discharge to be observed, in contrast to previous isotope studies which have given averaged transit time distributions based on series of samples. In addition, tritium reveals the wide spectrum of ages present in streams whereas oxygen-18 or chloride variations only show the younger ages (Stewart et al., 2010). It was found that the mean transit time (MTT) data could be reasonably represented by straight lines in log-log plots, indicating power law relationships between MTT and discharge. Similar power law behaviour has been observed for the rock forming elements such as silica in streamwaters (Godsey et al., 2009). Case studies are presented for two New Zealand catchments, both with volcanic ash substrates. Toenepi is a dairy catchment near Hamilton, which shows well-constrained power law relationships between MTT and discharge, and between silica concentration and discharge (Morgenstern et al., 2010). Baseflow MTTs vary from 2.5 to 157 years. Tutaeuaua is a pastoral farming catchment near Taupo. Results for nested catchments along the stream also show power law relationships for both MTT and silica with discharge. Streamwater MTTs vary from 1 to 11 years. The results indicate that (1) relatively old waters dominate many streams, (2) streamwater ages vary with discharge, and (3) age, like silica, varies according to power law relationships with stream discharge. References: Godsey, S.E., Kirchner, J.W., Clow, D.W. Hydrological Processes 23, 1844-1864, 2009. Morgenstern, U., Stewart M. K., Stenger, R. Hydrology and Earth System Sciences 14, 2289-2301, 2010. Stewart, M.K., Morgenstern, U., McDonnell, J.J. Hydrological Processes 24(12), 1646-1659, 2010.

  5. Oxygen isotopes in tree rings show good coherence between species and sites in Bolivia

    Baker, Jessica C. A.; Hunt, Sarah F. P.; Clerici, Santiago J.; Newton, Robert J.; Bottrell, Simon H.; Leng, Melanie J.; Heaton, Timothy H. E.; Helle, Gerhard; Argollo, Jaime; Gloor, Manuel; Brienen, Roel J. W.

    2015-10-01

    A tree ring oxygen isotope (δ18OTR) chronology developed from one species (Cedrela odorata) growing in a single site has been shown to be a sensitive proxy for rainfall over the Amazon Basin, thus allowing reconstructions of precipitation in a region where meteorological records are short and scarce. Although these results suggest that there should be large-scale (> 100 km) spatial coherence of δ18OTR records in the Amazon, this has not been tested. Furthermore, it is of interest to investigate whether other, possibly longer-lived, species similarly record interannual variation of Amazon precipitation, and can be used to develop climate sensitive isotope chronologies. In this study, we measured δ18O in tree rings from seven lowland and one highland tree species from Bolivia. We found that cross-dating with δ18OTR gave more accurate tree ring dates than using ring width. Our "isotope cross-dating approach" is confirmed with radiocarbon "bomb-peak" dates, and has the potential to greatly facilitate development of δ18OTR records in the tropics, identify dating errors, and check annual ring formation in tropical trees. Six of the seven lowland species correlated significantly with C. odorata, showing that variation in δ18OTR has a coherent imprint across very different species, most likely arising from a dominant influence of source water δ18O on δ18OTR. In addition we show that δ18OTR series cohere over large distances, within and between species. Comparison of two C. odorata δ18OTR chronologies from sites several hundreds of kilometres apart showed a very strong correlation (r = 0.80, p < 0.001, 1901-2001), and a significant (but weaker) relationship was found between lowland C. odorata trees and a Polylepis tarapacana tree growing in the distant Altiplano (r = 0.39, p < 0.01, 1931-2001). This large-scale coherence of δ18OTR records is probably triggered by a strong spatial coherence in precipitation δ18O due to large-scale controls. These results highlight the strength of δ18OTR as a precipitation proxy, and open the way for temporal and spatial expansion of precipitation reconstructions in South America.

  6. Planetarium Shows: Public Outreach and Changing the Approach to Classroom Teaching

    Morris, P. A.; Reiff, P.; Sumners, C.

    2009-05-01

    We are successfully using the planetarium experience as a method of increasing the public's knowledge of science for the last few years. The results with pre and post testing have shown that there is an increased level of science knowledge. With this level of achievement it was plausible that the next step would be introducing it into the classroom, particularly at an open admissions university with a multi-racial and ethnic population and in the non-majors science courses. Creating an atmosphere of excitement and interest in science within this group of students is difficult, particularly with those students who have minimal exposure to science and have little or no interest in the subject. They have preconceived ideas that the subject is boring, difficult and has no relation to their future career paths. Coupled with this apathy, not only in students but in segments of the public, there is an increasing need to educate all groups on environmental issues and the need to promote science and science research. Traditional teaching methods are not effective, and based on the outreach levels of success, we are introducing planetarium shows that are not only entertaining but include scientific concepts Most colleges and universities do not have a fixed planetarium, but a portable planetarium can serve the same purpose. The planetarium does not replace the traditional classroom and laboratory experience, but augments it. The shows, including the freeware Stellarium, can be incorporated into college and university classes from the physical to the biological sciences. For example, the show Titanic includes information on the effects of solar maximums and minimums on climate and changes in the last 100 years on ship building. Another show, Ice Worlds, includes information on polar geology and biology but also explains its importance as a terrestrial analogue for interpreting the remote sensing information obtained with robotic missions to the icy worlds in our outer solar system. Transferring some of the successful public outreach models to the classroom can be an important step in changing how we teach non-science majors courses. The student, by merely increasing their excitement about science, will communicate this change in attitude to their family, but also to other members of their community.

  7. Vv-AMP1, a ripening induced peptide from Vitis vinifera shows strong antifungal activity

    Vivier Melan A

    2008-07-01

    Full Text Available Abstract Background Latest research shows that small antimicrobial peptides play a role in the innate defense system of plants. These peptides typically contribute to preformed defense by developing protective barriers around germinating seeds or between different tissue layers within plant organs. The encoding genes could also be upregulated by abiotic and biotic stimuli during active defense processes. The peptides display a broad spectrum of antimicrobial activities. Their potent anti-pathogenic characteristics have ensured that they are promising targets in the medical and agricultural biotechnology sectors. Results A berry specific cDNA sequence designated Vv-AMP1, Vitis vinifera antimicrobial peptide 1, was isolated from Vitis vinifera. Vv-AMP1 encodes for a 77 amino acid peptide that shows sequence homology to the family of plant defensins. Vv-AMP1 is expressed in a tissue specific, developmentally regulated manner, being only expressed in berry tissue at the onset of berry ripening and onwards. Treatment of leaf and berry tissue with biotic or abiotic factors did not lead to increased expression of Vv-AMP1 under the conditions tested. The predicted signal peptide of Vv-AMP1, fused to the green fluorescent protein (GFP, showed that the signal peptide allowed accumulation of its product in the apoplast. Vv-AMP1 peptide, produced in Escherichia coli, had a molecular mass of 5.495 kDa as determined by mass spectrometry. Recombinant Vv-AMP1 was extremely heat-stable and showed strong antifungal activity against a broad spectrum of plant pathogenic fungi, with very high levels of activity against the wilting disease causing pathogens Fusarium oxysporum and Verticillium dahliae. The Vv-AMP1 peptide did not induce morphological changes on the treated fungal hyphae, but instead strongly inhibited hyphal elongation. A propidium iodide uptake assay suggested that the inhibitory activity of Vv-AMP1 might be associated with altering the membrane permeability of the fungal membranes. Conclusion A berry specific cDNA clone, Vv-AMP1, was isolated and characterized and shown to encode a plant defensin. Recombinant Vv-AMP1 displayed non-morphogenic antifungal activity against a broad spectrum of fungi, probably altering the membrane permeability of the fungal pathogens. The expression of this peptide is highly regulated in Vitis vinifera, hinting at an important defense role during berry-ripening.

  8. Populations of Monarch butterflies with different migratory behaviors show divergence in wing morphology.

    Altizer, Sonia; Davis, Andrew K

    2010-04-01

    The demands of long-distance flight represent an important evolutionary force operating on the traits of migratory species. Monarchs are widespread butterflies known for their annual migrations in North America. We examined divergence in wing morphology among migratory monarchs from eastern and western N. America, and nonmigratory monarchs in S. Florida, Puerto Rico, Costa Rica, and Hawaii. For the three N. American populations, we also examined monarchs reared in four common environment experiments. We used image analysis to measure multiple traits including forewing area and aspect ratio; for laboratory-reared monarchs we also quantified body area and wing loading. Results showed wild monarchs from all nonmigratory populations were smaller than those from migratory populations. Wild and captive-reared eastern monarchs had the largest and most elongated forewings, whereas monarchs from Puerto Rico and Costa Rica had the smallest and roundest forewings. Eastern monarchs also had the largest bodies and high measures of wing loading, whereas western and S. Florida monarchs had less elongated forewings and smaller bodies. Among captive-reared butterflies, family-level effects provided evidence that genetic factors contributed to variation in wing traits. Collectively, these results support evolutionary responses to long-distance flight in monarchs, with implications for the conservation of phenotypically distinct wild populations. PMID:20067519

  9. The mycotoxins deoxynivalenol and nivalenol show invivo synergism on jejunum enterocytes apoptosis.

    Cheat, Sophal; Pinton, Philippe; Cossalter, Anne-Marie; Cognie, Juliette; Vilario, Maria; Callu, Patrick; Raymond-Letron, Isabelle; Oswald, Isabelle P; Kolf-Clauw, Martine

    2016-01-01

    The mycotoxins deoxynivalenol (DON) and nivalenol (NIV), worldwide cereal contaminants, raise concerns for human and animal gut health, following exposure through contaminated food and feed. The aim of this work was to analyze the effects of DON and NIV, alone or associated, on the intestinal pig mucosa. Jejunal loops were used for testing DON and NIV individually and in combination (1:1) after a single exposure, for 24h. For repeated exposure, piglets received a natural contaminated feed, with DON or with DON+NIV for 28 days. Histological investigations, proliferation and apoptosis assessments were conducted. Both experiments were concordant for the total-cell proliferation decreased at the villus tips after DON or DON+NIV at 10?M acutely, or repeatedly, by 30-35% and 20-25%, respectively. In loops model, apoptotic enterocytes at villus tips increased dose-dependently after DON, NIV alone or DON+NIV in combination. The combination in loops at 10?M showed higher effects on proliferation and apoptosis than DON alone, and synergism was shown for villus apoptotic enterocyte. These results are to be considered for NIV consumer risk assessment. Our results demonstrate the invivo disruption of the intestinal balance proliferation/apoptosis explaining, at least partly, the disruption of intestinal barrier by these mycotoxins. PMID:26631294

  10. Vortexlet models of flapping flexible wings show tuning for force production and control

    Mountcastle, A M [Department of Organismic and Evolutionary Biology, Harvard University, Concord Field Station, Bedford, MA 01730 (United States); Daniel, T L, E-mail: mtcastle@u.washington.ed [Department of Biology, University of Washington, Seattle, WA 98195 (United States)

    2010-12-15

    Insect wings are compliant structures that experience deformations during flight. Such deformations have recently been shown to substantially affect induced flows, with appreciable consequences to flight forces. However, there are open questions related to the aerodynamic mechanisms underlying the performance benefits of wing deformation, as well as the extent to which such deformations are determined by the boundary conditions governing wing actuation together with mechanical properties of the wing itself. Here we explore aerodynamic performance parameters of compliant wings under periodic oscillations, subject to changes in phase between wing elevation and pitch, and magnitude and spatial pattern of wing flexural stiffness. We use a combination of computational structural mechanics models and a 2D computational fluid dynamics approach to ask how aerodynamic force production and control potential are affected by pitch/elevation phase and variations in wing flexural stiffness. Our results show that lift and thrust forces are highly sensitive to flexural stiffness distributions, with performance optima that lie in different phase regions. These results suggest a control strategy for both flying animals and engineering applications of micro-air vehicles.

  11. Vortexlet models of flapping flexible wings show tuning for force production and control

    Insect wings are compliant structures that experience deformations during flight. Such deformations have recently been shown to substantially affect induced flows, with appreciable consequences to flight forces. However, there are open questions related to the aerodynamic mechanisms underlying the performance benefits of wing deformation, as well as the extent to which such deformations are determined by the boundary conditions governing wing actuation together with mechanical properties of the wing itself. Here we explore aerodynamic performance parameters of compliant wings under periodic oscillations, subject to changes in phase between wing elevation and pitch, and magnitude and spatial pattern of wing flexural stiffness. We use a combination of computational structural mechanics models and a 2D computational fluid dynamics approach to ask how aerodynamic force production and control potential are affected by pitch/elevation phase and variations in wing flexural stiffness. Our results show that lift and thrust forces are highly sensitive to flexural stiffness distributions, with performance optima that lie in different phase regions. These results suggest a control strategy for both flying animals and engineering applications of micro-air vehicles.

  12. Akt shows variable sensitivity to an Hsp90 inhibitor depending on cell context

    Hsp90 inhibitors are currently in clinical trials for cancer therapy based on their ability to promote proteasomal degradation of oncogenic protein kinases and nuclear receptors. Results from recent studies suggest that cancer cells are more sensitive to these inhibitors than cells from healthy tissues. We analyzed an immortalized cell line Ba/F3 for sensitivity to the Hsp90 inhibitor geldanamycin in the absence and presence of the oncogenic tyrosine fusion kinase NPM-ALK expressed from a retroviral vector. Our results showed that NPM-ALK expression makes Akt and Cdk4 more resistant to degradation in the presence of geldanamycin, and there was a slightly reduced amount of apoptosis. The mechanism underlying the effect of NPM-ALK on Akt stability was probed by comparison of the turnover of the kinase after translation inhibition and geldanamycin treatment. We observed that Akt was degraded more rapidly in the presence of GA than upon translation inhibition without NPM-ALK expression. This suggests that NPM-ALK protects the mature kinase. Furthermore, Akt failed to bind to the Cdc37 chaperone in cells expressing NPM-ALK, which also correlates with increased Akt stability

  13. Glacial trees from the La Brea tar pits show physiological constraints of low CO₂.

    Gerhart, Laci M; Harris, John M; Nippert, Jesse B; Sandquist, Darren R; Ward, Joy K

    2012-04-01

    • While studies of modern plants indicate negative responses to low [CO₂] that occurred during the last glacial period, studies with glacial plant material that incorporate evolutionary responses are rare. In this study, physiological responses to changing [CO₂] were compared between glacial (La Brea tar pits) and modern Juniperus trees from southern California. • Carbon isotopes were measured on annual rings of glacial and modern Juniperus. The intercellular:atmospheric [CO₂] ratio (c(i) /c(a) ) and intercellular [CO₂] (c(i) ) were then calculated on an annual basis and compared through geologic time. • Juniperus showed constant mean c(i) /c(a) between the last glacial period and modern times, spanning 50,000 yr. Interannual variation in physiology was greatly dampened during the last glacial period relative to the present, indicating constraints of low [CO₂] that reduced responses to other climatic factors. Furthermore, glacial Juniperus exhibited low c(i) that rarely occurs in modern trees, further suggesting limiting [CO₂] in glacial plants. • This study provides some of the first direct evidence that glacial plants remained near their lower carbon limit until the beginning of the glacial-interglacial transition. Our results also suggest that environmental factors that dominate carbon-uptake physiology vary across geologic time, resulting in major alterations in physiological response patterns through time. PMID:22187970

  14. Metabolic remodeling agents show beneficial effects in the dystrophin-deficient mdx mouse model

    Jahnke Vanessa E

    2012-08-01

    Full Text Available Abstract Background Duchenne muscular dystrophy is a genetic disease involving a severe muscle wasting that is characterized by cycles of muscle degeneration/regeneration and culminates in early death in affected boys. Mitochondria are presumed to be involved in the regulation of myoblast proliferation/differentiation; enhancing mitochondrial activity with exercise mimetics (AMPK and PPAR-delta agonists increases muscle function and inhibits muscle wasting in healthy mice. We therefore asked whether metabolic remodeling agents that increase mitochondrial activity would improve muscle function in mdx mice. Methods Twelve-week-old mdx mice were treated with two different metabolic remodeling agents (GW501516 and AICAR, separately or in combination, for 4 weeks. Extensive systematic behavioral, functional, histological, biochemical, and molecular tests were conducted to assess the drug(s' effects. Results We found a gain in body and muscle weight in all treated mice. Histologic examination showed a decrease in muscle inflammation and in the number of fibers with central nuclei and an increase in fibers with peripheral nuclei, with significantly fewer activated satellite cells and regenerating fibers. Together with an inhibition of FoXO1 signaling, these results indicated that the treatments reduced ongoing muscle damage. Conclusions The three treatments produced significant improvements in disease phenotype, including an increase in overall behavioral activity and significant gains in forelimb and hind limb strength. Our findings suggest that triggering mitochondrial activity with exercise mimetics improves muscle function in dystrophin-deficient mdx mice.

  15. A stochastic automaton shows how enzyme assemblies may contribute to metabolic efficiency

    Ripoll Camille

    2008-03-01

    Full Text Available Abstract Background The advantages of grouping enzymes into metabolons and into higher order structures have long been debated. To quantify these advantages, we have developed a stochastic automaton that allows experiments to be performed in a virtual bacterium with both a membrane and a cytoplasm. We have investigated the general case of transport and metabolism as inspired by the phosphoenolpyruvate:sugar phosphotransferase system (PTS for glucose importation and by glycolysis. Results We show that PTS and glycolytic metabolons can increase production of pyruvate eightfold at low concentrations of phosphoenolpyruvate. A fourfold increase in the numbers of enzyme EI led to a 40% increase in pyruvate production, similar to that observed in vivo in the presence of glucose. Although little improvement resulted from the assembly of metabolons into a hyperstructure, such assembly can generate gradients of metabolites and signaling molecules. Conclusion in silico experiments may be performed successfully using stochastic automata such as HSIM (Hyperstructure Simulator to help answer fundamental questions in metabolism about the properties of molecular assemblies and to devise strategies to modify such assemblies for biotechnological ends.

  16. Identification and Characterisation CRN Effectors in Phytophthora capsici Shows Modularity and Functional Diversity.

    Stam, Remco; Jupe, Julietta; Howden, Andrew J M; Morris, Jenny A; Boevink, Petra C; Hedley, Pete E; Huitema, Edgar

    2013-01-01

    Phytophthora species secrete a large array of effectors during infection of their host plants. The Crinkler (CRN) gene family encodes a ubiquitous but understudied class of effectors with possible but as of yet unknown roles in infection. To appreciate CRN effector function in Phytophthora, we devised a simple Crn gene identification and annotation pipeline to improve effector prediction rates. We predicted 84 full-length CRN coding genes and assessed CRN effector domain diversity in sequenced Oomycete genomes. These analyses revealed evidence of CRN domain innovation in Phytophthora and expansion in the Peronosporales. We performed gene expression analyses to validate and define two classes of CRN effectors, each possibly contributing to infection at different stages. CRN localisation studies revealed that P. capsici CRN effector domains target the nucleus and accumulate in specific sub-nuclear compartments. Phenotypic analyses showed that few CRN domains induce necrosis when expressed in planta and that one cell death inducing effector, enhances P. capsici virulence on Nicotiana benthamiana. These results suggest that the CRN protein family form an important class of intracellular effectors that target the host nucleus during infection. These results combined with domain expansion in hemi-biotrophic and necrotrophic pathogens, suggests specific contributions to pathogen lifestyles. This work will bolster CRN identification efforts in other sequenced oomycete species and set the stage for future functional studies towards understanding CRN effector functions. PMID:23536880

  17. First results from HERA

    The new electron-proton collider HERA at DESY has been put into operation together with the experiments H1 and ZEUS. With HERA, high energy physics has entered a new territory far beyond the reach of previous lepton nucleon scattering experiments. The very first run has already given new results on several topics. Deep inelastic neutral current scattering has been extended by two orders of magnitude towards very small x values. For photoproduction the total cross section has been measured and a large excess of events from hard scattering has been observed. The general characteristics of these hard scatters agrees with the expectations for direct and resolved photon interactions. (orig.)

  18. Results from AMANDA

    Wiebusch, C; Bai, X; Barwick, S W; Becka, T; Becker, K H; Bertrand, D; Bernadini, E; Binon, Freddy G; Biron, A; Boser, S; Botner, O; Bouchta, A; Bouhali, O; Burgess, T; Carius, S; Castermans, T; Chen, A; Chirkin, D; Conrad, J; Cooley, J; Cowen, D F; Davour, A; De Clercq, C; De Young, T R; Desiati, P; Dewulf, J P; Doksus, P; Ekstrom, P; Feser, T; Gaisser, T K; Gaug, M; Gerhardt, L; Goldschmidt, A; Hallgren, A; Halzen, F; Hanson, K; Hardtke, R; Hauschildt, T; Hellwig, M; Herquet, P; Hill, G C; Hulth, P O; Hundertmark, S; Jacobsen, J; Karle, A; Koci, B; Kpke, L; Kowalski, M; Khn, K; Lamoureux, J I; Leich, H; Leuthold, M J; Lindahl, P; Liubarsky, I; Madsen, J; Marciniewski, P; Matis, H S; McParland, C P; Minaeva, Y; Minocinovic, P; Mock, P C; Morse, R; Nahnhauer, R; Neunhoffer, T; Niessen, P; Nygren, D R; gelman, H B; Olbrechts, P; Prez de los Heros, C; Pohl, A C; Price, P B; Przybylski, G T; Rawlins, K; Resconi, E; Rhode, W; Ribordy, M; Richter, S; Rodrguez-Martino, J; Ross, D; Sander, H G; Schmidt, T; Schneider, D; Schwarz, R; Silvestri, A; Solarz, M; Spiczak, G M; Spiering, C; Steele, D; Steffen, P; Stokstad, R G; Sudhoff, P; Sulanke, K H; Taboada, I; Thollander, L; Tilav, S; Walck, C; Weinheimer, C; Wiebusch, C; Wiedemann, C; Wischnewski, R; Wissing, H; Woschnagg, K; Yodh, G B; Young, S

    2002-01-01

    The Antarctic Muon and Neutrino Detector Array (AMANDA) is a high- energy neutrino telescope operating at the geographic South Pole. It is a lattice of photomultiplier tubes buried deep in the polar ice. The primary goal of this detector is to discover astrophysical sources of high energy neutrinos. We describe the detector methods of operation and present results from the AMANDA-B10 prototype. We demonstrate the improved sensitivity of the current AMANDA-II detector. We conclude with an outlook to the envisioned sensitivity of the future IceCube detector. (37 refs).

  19. Recent results from KLOE

    2008-01-01

    In this report I will present the recent results on K mesons from the KLOE experiment at the DAFNE e+e- collider working at the center of mass energy ~1GeV ~m_{phi}. They include V_{us} determinations, the test on the unitarity of the first row of the CKM matrix and the related experimental measurements. Tests of lepton universality from leptonic and semileptonic decays will be also discussed. Then I will present tests of quantum coherence, CPT and Lorentz symmetry performed by studying the time evolution of the neutral kaon system.

  20. [Ureteroscopy. Experience and results].

    Delgado, G; Alvarado, A; de Solanilla, E C

    1991-09-01

    Ureteroscopy is an Endo-urological procedure which has been practiced around the world in all teaching centers of Urology. It presents obvious advantages. Our experience has been satisfactory, not only due to the coordinated and joint work, but for the results obtained in behalf of our patients who went back to their regular activities shortly after. As all the new procedures, it has a learning curve which is given after the initial training has been acquired but its performance will give expertise, same as radiologic technology and the development of new instruments with smaller diameter and accessories which allow the easier access to ureter and lithotripsy. PMID:1767038